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Sample records for alta densidad hdl

  1. TOTAL CHOLESTEROL, HIGH DENSITY LIPOPROTEINS (HDL AND CORTISOL PLASMA LEVELS, AND THEIR BIORHYTMICITY, IN 24 HOURS, THROUGHOUT YEAR, IN IDEAL-POLWARTH RAMS NÍVEIS PLASMÁTICOS DE COLESTEROL TOTAL, LIPOPROTEÍNAS DE ALTA DENSIDADE (HDL E CORTISOL, E SUA BIORRITMICIDADE, EM CARNEIROS IDEAL-POLWARTH

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    Alcides de Amorim Ramos

    2006-12-01

    Full Text Available To evaluate the mean plasma concentrations of total cholesterol (TC, high density lipoproteins (HDL and cortisol, blood samples were collected of five Ideal-Polwarth rams, maintained at 22?53’S latitude, in semi-confinement, every two months throughout the year, by 24h period, with 2-hour intervals between colects. The TC, changed 40.70?1,11mg/dL (April and 61.48?1,11mg/dL (December, between months, while HDL changed 22.16?0.23mg/dL (December as 33.40?0.23mg/dL (February, but not make evident a circannual rhythm in this levels. The TC presented the lowest value at 16:30h (50.40?1.57mg/dL and the highest value at 8:30h collect (54.67?1.57mg/dL; the HDL lowest level was at 10:30h (27.04?0.33mg/dL and the highest level also at 8:30h collect (28.49?0.33mg/dL, however without permit circadian rhythm determination in your plasma concentrations. Similarly, the cortisol plasma concentrations, between collect months, presents variable, however without demonstrate circadian rhythm in this hormone secretion. In relation to different collection’s moments, throughout months, it wasn’t possible to define, by statistical analysis, a circadian rhythm of cortisol secretion. KEY WORDS: Ovine, adrenal hormone, biochemistry metabolites, circadian rhythm. Visando avaliar as concentrações médias de colesterol total (CT, lipoproteínas de alta densidade (HDL e cortisol plasmáticos, foram colhidas amostras de sangue de cinco carneiros Ideal-Polwarth, alocados em latitude 22°53’S, em regime de semiconfinamento, a cada dois meses, ao longo de um ano, com as colheitas em um período de 24 horas, e intervalos de duas horas entre elas. O CT oscilou entre 40,70±1,11mg/dL (abril e 61,48±1,11mg/dL (dezembro, entre os meses, enquanto HDL variou de 22,16±0,23mg/dL (dezembro a 33,40±0,23mg/dL (fevereiro, mas não evidenciando um ritmo circanual em seus níveis. O CT apresentou seu valor mínimo na colheita das 16h30min (50,40±1,57mg/dL e o máximo às 8h30min

  2. Sistemas de producción de fresa de altas densidades.

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    Ramírez Gómez, Humberto

    2011-01-01

    En México se produce fresa con alta tecnología pero existe escasa investigación sobre la productividad de la fresa en sistemas hidropónicos con altas densidades. El presente estudio se realizó con la finalidad de evaluar la fisiología, rendimiento, calidad y rentabilidad de la fresa de altas densidades en cuatro sistemas hidropónicos. Los tratamientos estudiados fueron: bolsas individuales (BI), vertical con tres tubos (V3T), vertical con cuatro tubos (V4T) y vertical con macetas hidropónicas...

  3. Waist circumference is better associated with high density lipoprotein (HDL-c than with body mass index (BMI in adults with metabolic syndrome Circunferencia de la cintura es mejor asociado con lipoproteínas de alta densidad (LAD-C que con el índice de masa corporal (IMC en adultos con síndrome metabólico

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    S. T. Arimura

    2011-12-01

    Full Text Available Background: The measurement of waist circumference (WC is the most prevalent cause of the metabolic syndrome (MS. Objective: The aim of this study was to correlate WC and BMI with high-density lipoprotein (HDL-c levels in patients with MS being consulted by the Family Health Program (PSF, Brazil. Methods: This cross-sectional study was conducted from September to November 2008 with 42 patients (29 women and 13 men from 35 to 77 years. Dietary intake was reported, and biochemical and body composition measures were taken. Results: The HDL-c levels were higher in women when compared to men (48.4 ± 8.1 mg/dL vs. 36.4 ± 7.8 mg/dL. However, the triglycerides (TG/HDL-c ratio and TG concentrations were lower in women (3.8 ± 1.5 and 178.0 ± 57.8 mg/dL, respectively than in men (9.4 ± 8.5 and 471.5 ± 501.5 mg/dL, respectively. Regarding skinfold profile, the triceps was greater in females (37.0 ± 8.4 cm vs. 20.7 ± 10.5 cm. The dietetic profile showed that women had a lower intake of energy, fiber, phosphorus and sodium. The fruits and vegetables intake was diminished in the participants of this study, as less than 60% of the women and 50% of men met the daily recommendations. Approximately 54% of men and 28% of women had a lower intake of dairy products daily. Moreover, the results shows that the WC was negatively correlated to HDL-c (r = -0.41, p 0.06. Conclusion: Our findings showed that WC is a better predictor of changes in HDL-c than BMI.Antecedentes: La medición de la circunferencia de la cintura (CC es la causa más prevalente del síndrome metabólico (SM. Objetivo: el propósito de este estudio fue correlacionar la CC y el IMC con las concentraciones de lipoproteínas de densidad elevada (HDL-c en pacientes con SM vistos en consulta del Programa de salud familiar (PSF, de Brasil. Métodos: Este estudio trasversal se realizó entre septiembre y noviembre de 2008 en 42 pacientes (29 mujeres y 13 hombres de 35 a 77 años. Se registró la

  4. Cultivo de cachama blanca en altas densidades y en dos sistemas cerrados

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    Germán Poleo

    2011-04-01

    Full Text Available El objetivo de este trabajo fue evaluar la tolerancia de la cachama blanca, Piaractus brachypomus, a cultivos en altas densidades en sistemas cerrados. Novecientos alevines de 44,3±26 g de peso, se distribuyeron en seis tanques de concreto, con 4,8 m³ de agua. Tres tanques presentaron cero recambio de agua (SCR, y en otros tres, el agua se hizo circular a través de un bioclarificador (SRA. Ambos tratamientos presentaron fuerte aireación para mantener los sólidos en suspensión y suministrar aire. Los peces se alimentaron a saciedad con pienso comercial por 192 días. Los parámetros de calidad de agua como: oxígeno disuelto, amonio total, nitritos, nitratos, alcalinidad, dureza, temperatura y pH, se midieron semanalmente. Los peces en el SCR crecieron a una tasa de 2,34±0,05 g por día, y tuvieron conversión alimenticia de 1,5±0,06, densidad final de 12,96±0,53 kg m-3, y peso final de 449,5±99 g. En el SRA, los peces crecieron 2,33±0,03 g por día, con conversión alimenticia de 1,6±0,07, densidad final de 12,13±1,12 kg m-3, y peso final de 446,5±10 g. La cachama blanca puede ser cultivada en sistemas cerrados con cero recambio de agua en altas densidades.

  5. Cultivo de cachama blanca en altas densidades y en dos sistemas cerrados

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    Germán Poleo; José Vicente Aranbarrio; Lismen Mendoza; Oneida Romero

    2011-01-01

    El objetivo de este trabajo fue evaluar la tolerancia de la cachama blanca, Piaractus brachypomus, a cultivos en altas densidades en sistemas cerrados. Novecientos alevines de 44,3±26 g de peso, se distribuyeron en seis tanques de concreto, con 4,8 m³ de agua. Tres tanques presentaron cero recambio de agua (SCR), y en otros tres, el agua se hizo circular a través de un bioclarificador (SRA). Ambos tratamientos presentaron fuerte aireación para mantener los sólidos en suspensión y suministrar ...

  6. Morfología y propiedades de politereftalato de etilen-glicol y polietileno de alta densidad

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    Guerrero, Carlos; Lozano, Tomás; González, Virgilio; Arroyo, Eliud

    2003-01-01

    Se estudiaron mezclas de politereftalato de etilen- glicol, PET y polietileno de alta densidad, HDPE, con y sin agente compatibilizante. Ambos materiales se usan ampliamente en la industria de bebidas carbonatadas. El agente compatibilizante que se usó fue un copolímero de etileno y ácido metacrílico parcialmente neutralizado con zinc (Surlyn). Como hipótesis se planteó que el segmento olefínico del Surlyn podría ser compatible con el HDPE, mientras que los grupos c...

  7. Efecto de la temperatura en la densidad de la leche entera bajo alta presión

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    Guignon, Bérengère; Rey I.; Sanz Martínez, Pedro D.

    2012-01-01

    El procesado con alta presión se está convirtiendo en una eficaz tecnología de conservación. Con ella, se prolonga la vida útil de los alimentos, manteniendo sus cualidades. Para controlar y optimizar la uniformidad de los tratamientos, cada vez se emplea más, la modelización matemática. La realización de los correspondientes cálculos, requieren disponer de las propiedades físicas de los alimentos. Entre ellas está la densidad. Ante la carencia de estos datos, se ha llevad...

  8. Estrutura, metabolismo e funções fisiológicas da lipoproteína de alta densidade Structure, metabolism and physiologic functions of high-density lipoproteins

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    Emerson Silva Lima

    2006-06-01

    Full Text Available Diversos estudos clínicos, epidemiológicos e experimentais têm mostrado de maneira incontestável a relação entre dosagem sérica dos níveis de lipoproteína de alta densidade (HDL e doença cardiovascular. Baixos níveis de HDL estão presentes em aproximadamente 10% da população e representam um dos mais freqüentes achados de dislipidemia nos pacientes com doença arterial coronariana (DAC. Esses níveis reduzidos de HDL poderiam ser incapazes de efetivamente eliminar o excesso de colesterol das paredes vasculares, contribuindo para o fenômeno inflamatório que caracteriza a patogênese da aterosclerose nas suas fases iniciais. Outros inúmeros estudos têm convincentemente mostrado que a HDL também exerce efeitos diretos sobre os processos inflamatórios, por exemplo, através da modulação da expressão de diversas proteínas de fase aguda. Além disso, a HDL também possui diversos outros efeitos antiaterogênicos, como efeitos antioxidantes, inibição da agregação plaquetária e da migração de monócitos. O presente artigo faz uma revisão da literatura atual sobre o metabolismo da HDL e suas principais ações na prevenção da doença arterial coronariana.Several experimental, clinical and epidemiological researches have shown the incontestable causal relationship between low high-density lipoprotein (HDL plasma concentrations and cardiovascular pathology on an atherosclerotic basis. Low HDL levels characterize about 10% of the general population and they represent the most frequent dyslipidemia in patients with coronary artery disease. Reduced HDL concentrations would be unable to effectively eliminate the cholesterol excess at the vascular wall, contributing to the inflammatory phenomenon that characterizes the pathogenesis of atherosclerosis since its initial phases. Results of numerous studies reasonably allow supposing that HDL is able to exert, also directly, anti-inflammatory actions through the modulation of

  9. LAS LIPOPROTEÍNAS DE ALTA DENSIDAD: PROTECTORAS VASCULARES CONTRA LA ATEROSCLEROSIS / High-density lipoproteins: vascular guards against atherosclerosis

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    Yosit Ponce Gutiérrez

    2013-10-01

    Full Text Available Resumen El incremento de los niveles de lipoproteínas de alta densidad y sus potenciales beneficios en la aterosclerosis ha sido motivo para la realización de este artículo, en el que se efectúa una revisión sobre la información médica más reciente que existe sobre el tema y su posterior actualización. Se describen la estructura de estas lipoproteínas, sus efectos vasculares ateroprotectores, el transporte reverso de colesterol, y se exponen las nuevas estrategias que permiten incrementar sus concentraciones en el organismo, ya que estudios recientes indican que estabilizan las placas de ateroma de una manera acelerada, por lo que constituyen una novedosa alternativa terapéutica en los pacientes de alto riesgo. De esta forma se consolidan los conocimientos sobre las lipoproteínas de alta densidad, con el fin de brindar una atención de más calidad en la prevención, control y tratamiento de esta frecuente enfermedad. / Abstract Increasing levels of high-density lipoproteins and their potential benefits in Atherosclerosis motivated us to write this article in order to update knowledge on this topic. The structure of these lipoproteins is described, as well as their atheroprotective vascular effects and the reverse cholesterol transport. New strategies to increase their concentration in the body are presented, as recent studies indicate that they stabilize atherosclerotic plaques in an expedited manner. Therefore, it constitutes a novel therapeutic alternative in high risk patients. This will update the knowledge on highdensity lipoproteins, in order to provide a better quality care in the prevention, control and treatment of this common disease.

  10. TSH Normal Alta: Su relación con bajo HDL-Colesterol en mujeres con resistencia a la insulina con independencia de otros posibles factores concurrentes

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    J Rezzónico

    2008-12-01

    Full Text Available Objetivo: En el hipotiroidismo tanto clínico como subclínico se han descripto alteraciones en el metabolismo lipídico, entre ellas la disminución de colesterol de lipoproteínas de alta densidad (HDL-C. Considerando el rango normal de TSH entre 0.4-3.0 μUI/ml y valores normales altos entre 2.0 y 3.0 μUI/ml, nosotros investigamos la hipótesis de que niveles normales altos de TSH e insulinorresistencia (IR se encuentran relacionados con HDL-C bajo en mujeres, en ausencia de otros factores concurrentes. Materiales y métodos: Estudiamos en un estudio transversal a 200 mujeres sanas, edad 18-50 años, eutiroideas, normotensas, con anticuerpos antiperoxidasa (ATPO negativos, no diabéticas, premenopáusicas, IMC 18.0-25.0 Kg/m2, perímetro de cintura ≤ 88 cm; perímetro de cuello ≤ a 35 cm. Se las dividió en 4 grupos, cada uno compuesto por 50 mujeres: Grupo 1 (G1 TSH ≥ 2μU/ml, IR; grupo 2 (G2 TSH ≥ 2μU/ml, no IR; grupo 3 (G3: TSH 0,40 a 1,99 μU/ml, IR; Grupo 4 (G4 TSH 0,40 a 1,99 μU/ml, no IR. Se les midió lípidos, TSH, T4 total y libre (T4L, glucosa e insulina basal y posprandial, índices HOMA y QUICKI y volumen tiroideo (VT. Resultados: Observamos que en el G1 el nivel de HDL-C (46,7± 8,1 mg/dl fue significativamente menor que en los restantes grupos. (vs G2: 56,8 ± 8,6 mg/dl; vs G3: 51,2 ± 7,6 mg/dl y vs G4: 56,5 ± 9,1 mg/dl. (pIt has been described abnormalities in lipid metabolism in clinical and subclinical hypothyroidism, including the reduction of high-density lipoprotein cholesterol (HDL-C. Considering the normal range for TSH between 0.4-3.0 uUI / ml and high-normal values between 2.0 and 3.0 uUI / ml, we investigated the hypothesis that in euthyroid women, high-normal TSH levels and insulin resistance (IR are associated with low HDL-C. We observed in euthyroid women with high-normal TSH and insulin resistance, without other factors, a significantly lower level of HDL-C than in non-insulin or insulin resistance

  11. LEVITACIÓN MAGNÉTICA EN FLUIDOS DE ALTA VISCOSIDAD Y DENSIDAD

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    ELIANA RONDÓN

    2010-01-01

    Full Text Available Este artículo describe el diseño de un sistema prototipo de levitador magnético que opera sumergido en un aceite dieléctrico de viscosidad y densidad sustancialmente superior a la del aire. Se implementó un compensador de atraso de fase en cascada con la planta con el fin de posicionar un cascaron esférico metálico en un punto en particular dentro del aceite. Se analizó el comportamiento del sistema al variar la viscosidad mediante la variación de la temperatura del fluido, observándose que a medida que su viscosidad disminuye con el aumento de temperatura, el sistema se torna inestable, mientras que para el caso del incremento de su viscosidad, el tiempo de respuesta se torna muy grande y el sistema responde lentamente. El sistema se simuló obteniéndose resultados que concuerdan estrechamente con los resultados del prototipo experimental que sirvió para validar el diseño.

  12. Síntesis y caracterización de un material compuesto a base de polietileno de alta densidad y magnetita pulverizada

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    Garzón Posada, Andrés Orlando

    2015-01-01

    En este trabajo se pretende producir un material compuesto a base de polietileno de alta densidad (HDPE) y magnetita pulverizada (Fe3O4) con el fin de caracterizar sus propiedades mecánicas, magnéticas y eléctricas. Este tipo de matrices poliméricas reforzadas con magnetita han sido motivo de estudio en los recientes años con el fin de desarrollar materiales con aplicaciones tecnológicas enfocadas a la ingeniería y a la biomedicina. Para optimizar el enfoque y el uso tanto de este material co...

  13. Cinética de cristalização não-isotérmica de resíduos de polietileno de alta densidade (PEAD)

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    Helson Moreira da Costa; Mônica Calixto de Andrade; Milena Diniz Lessa; Valéria Dutra Ramos

    2014-01-01

    Nesta investigação, diversos resíduos incolores ou coloridos pós-consumo de polietileno de alta densidade (PEAD) foram caracterizados através do índice de fluidez (MFI) e da calorimetria exploratória diferencial (DSC). A equação de Avrami modificada por Jeziorny, e os modelos de Kissenger e Friedman foram utilizados para descrever a cinética de cristalização não-isotérmica das amostras. Foi verificado que os pigmentos presentes no PEAD têm diferentes habilidades nucleantes durante o processo ...

  14. EVALUACIÓN DE LA PRODUCCIÓN DE PAPA CRIOLLA Solanum phureja CLON PAISA EN CONTENEDORES DE POLIETILENO DE ALTA DENSIDAD BAJO EL MARCO DE AGRICULTURA URBANA

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    Daniel Andrés Vega Castro

    2014-01-01

    Con el fin de evaluar la producción de papa criolla Solanum phureja clon Paisa en el contexto urbano, se desarrolló una investigación pionera de tipo descriptiva en la cual se evaluaron las siguientes variables: incidencia de plagas, peso en fresco por contenedor, peso fresco total y peso por clasificación comercial. Se utilizaron contenedores de doble fondo de polietileno de alta densidad y técnicas agroecológicas de producción, de las cuales se destaca la fertilización ...

  15. Densidad de ungulados en bosques de baja y alta presión de caza en el nororiente de la Amazonía peruana

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    Rolando Aquino

    2015-01-01

    Full Text Available Se proporciona información sobre tamaño de rebaño en pecaríes y densidad poblacional de éstos y otros ungulados para los bosques de baja y alta presión de caza del nororiente peruano. Durante el recorrido de 610 km de transecto de Noviembre-Diciembre 2012 en bosques de baja presión de caza y de 1218 km desde Febrero-Junio y Agosto-Octubre 2013 en bosques de alta presión de caza, fueron registrados 76 y 40 encuentros pertenecientes a seis y cinco especies, respectivamente; siendo los más comunes Pecari tajacu (35% y Mazama americana  (28%. El tamaño de rebaño en P. tajacu varió desde 2 a 8 individuos (tamaño promedio: 3,4±1,6 a 6±1,2. La densidad poblacional estimada para los ungulados fueron más altas en bosques de baja presión de caza sobresaliendo Tayassu pecari con 23,8 individuos/km2, seguido por P. tajacu con 14,4 individuos/km2, en tanto que la más baja fue para Tapirus terrestris (0,08 individuos/km2 y correspondió a los bosques de alta presión de caza. En los bosques de baja presión de caza, los encuentros más frecuentes con ungulados ocurrieron en el palmal de altura (46% y palmal de planicie (31%, en tanto que en el pantano arbóreo no hubo encuentros.

  16. Nanocompósitos poliméricos de polietileno de alta densidade contendo hidróxidos duplos lamelares intercalados com ânions derivados de corantes azo

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    Ademir Zimmermann

    2014-06-01

    Full Text Available O presente trabalho descreve a síntese e caracterização de hidróxidos duplos lamelares (HDL de Zn/Al na razão molar 2:1, os quais foram intercalados com íons cloreto hidratados e ânions derivados dos corantes azo alaranjado de metila (AM e alaranjado II (AII. Após caracterização, os materiais foram utilizados como cargas em polietileno de alta densidade (PEAD e nanocompósitos foram preparados por extrusão e injeção, seguindo a norma ASTM D638-10. Os teores de cargas variaram de 0,1 até 2% (incluindo-se os sais de sódio dos corantes e os nanocompósitos homogêneos foram avaliados em relação as suas propriedades estruturais, térmicas e mecânicas. De modo geral, após a adição das cargas existe somente uma pequena influência na temperatura de fusão e cristalização do PEAD. Para os HDLs contendo o pigmento intercalado com o ânion do corante AM e sais de sódio de ambos os corantes, as propriedades mecânicas apresentaram leve aumento do módulo e tensão de ruptura e diminuição do alongamento em relação ao polímero puro e um comportamento inverso foi observado para o ânion AII, além do HDL contendo ânions cloreto hidratados.

  17. Cinética de cristalização não-isotérmica de resíduos de polietileno de alta densidade (PEAD

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    Helson Moreira da Costa

    2014-08-01

    Full Text Available Nesta investigação, diversos resíduos incolores ou coloridos pós-consumo de polietileno de alta densidade (PEAD foram caracterizados através do índice de fluidez (MFI e da calorimetria exploratória diferencial (DSC. A equação de Avrami modificada por Jeziorny, e os modelos de Kissenger e Friedman foram utilizados para descrever a cinética de cristalização não-isotérmica das amostras. Foi verificado que os pigmentos presentes no PEAD têm diferentes habilidades nucleantes durante o processo de cristalização, bem como diferentes efeitos sobre a taxa de cristalização e a energia de ativação necessária para o transporte de segmentos macromoleculares para a superfície do cristal em crescimento.

  18. Compósitos de partículas de madeira de Eucalyptus grandis, polipropileno e polietileno de alta e baixa densidades Composites of Eucalyptus grandis wood, polypropylene, and high and low-density polyethylene particles

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    Emerson Gomes Milagres; Benedito Rocha Vital; Ricardo Marius Della Lúcia; Alexandre Santos Pimenta

    2006-01-01

    Este trabalho teve como objetivo determinar as propriedades de painéis fabricados com mistura de partículas de madeira de Eucalyptus grandis, polietileno de alta densidade, polietileno de baixa densidade e polipropileno. Empregaram-se duas formulações adesivas (uréia-formaldeído e uréia-formaldeído contendo 0,5% de epóxi). De modo geral, as propriedades dos painéis foram afetadas pela composição das partículas. Os painéis com melhores propriedades foram fabricados com 75% de partículas de mad...

  19. ALTAS DENSIDADES DE PLANTIO NA CULTURA DO ABACAXI CV. SMOOTH CAYENNE, SOB CONDIÇÕES DE SEQUEIRO HIGH PLANTING DENSITY FOR THE SMOOTH CAYENNE PINEAPPLE CROP, GROWN UNDER RAINFED CONDITIONS

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    LUCIANA LIMA DE ALMEIDA SANTANA; DOMINGO HAROLDO REINHARDT; GETÚLIO AUGUSTO PINTO DA CUNHA; RANULFO CORREIA CALDAS

    2001-01-01

    No Brasil têm-se usado densidades de plantio relativamente baixas para a obtenção de frutos grandes, com reflexos negativos na produtividade da cultura do abacaxi. No entanto, frutos cada vez menores têm sido comercializados no mercado internacional, o que poderá também ocorrer no mercado nacional. Este trabalho teve o objetivo de avaliar o efeito de altas densidades em sistemas de plantio em filas duplas sobre a produção quantitativa e qualitativa de abacaxi cv. Smooth Cayenne, sob condições...

  20. Efeito dos solventes orgânicos sobre o comportamento físico-químico do polietileno de alta densidade (PEAD e polipropileno (PP

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    Thieres Magaive Costa Pereira

    2014-06-01

    Full Text Available O mercado brasileiro de embalagens empregado ao armazenamento de petróleo e seus derivados vem crescendo a cada ano, sendo constituídas basicamente por polietileno de alta densidade (PEAD e polipropileno (PP. Contudo durante o armazenamento, a matriz polimérica fica exposta ao óleo, comprometendo suas propriedades físicas e consequentemente a durabilidade do material. Portanto, estudos relacionados com a interação entre solventes orgânicos e a matriz polimérica tornam-se importantes. Neste trabalho, a interação do PEAD e PP com diferentes solventes apolares (tolueno, n-heptano, n-decano e n-tetradecano foram estudadas em função da temperatura (25, 50 e 80 ºC. Os valores de ganho de massa, coeficientes de difusão, sorção, permeabilidade e parâmetros de mecanismo de transporte foram calculados. O ganho de massa observado para o PP foi maior do que para o PEAD, em todas as temperaturas, sendo que o tolueno foi o solvente responsável pelo maior ganho de massa, atingindo o equilíbrio em um menor intervalo de tempo. Esse resultado corrobora com os valores de coeficiente de difusão e de permeabilidade, que aumentaram na seguinte ordem: n-heptano > n-decano > n-tetradecano. Uma ordem inversa foi observada para os solventes alifáticos quando os valores de coeficiente de sorção foram calculados. O mecanismo de transporte foi também estudado através da regressão dos dados de sorção, sendo classificado como anômalo.

  1. Reologia de polietileno de alta densidade tenacificado com polietileno elastomérico Rheology of high density polyethylene toughened with elastomeric polyethylene

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    Maria José O. C. Guimarães

    2003-06-01

    Full Text Available Neste trabalho foram estudadas as propriedades reológicas de polietileno de alta densidade (HDPE tenacificado com dois tipos de elastômeros metalocênicos à base de poli(etileno-co-octeno (EOC. Estes elastômeros são polímeros comerciais com diferenças quanto ao peso molecular, índice de fluidez e índice Dow de reologia (DRI. Misturas físicas de HDPE e EOC foram processadas em extrusora monorosca Wortex (L/D=32, à 230 °C e 50 rpm, utilizando percentagem mássica dos EOCs de 5% a 80%. As propriedades reológicas foram avaliadas em experimentos estacionários e dinâmicos a 190 °C e taxas de cisalhamento na faixa de 90 s-1 a 1500 s-1 e freqüências na faixa de 10-1 rad/s a 10² rad/s. As misturas HDPE/EOC exibiram pseudoplasticidade e comportamento reológico complexo. A complexidade do comportamento reológico foi acentuada com o aumento do peso molecular e da concentração de ramificações de cadeia longa (DRI do EOC.In this work rheological properties of high density polyethylene toughened with two different grades of metallocene elastomers based on poly(ethylene-co-octene were studied. These elastomers were commercial polymers differing in molecular weight, and Dow Rheology Index (DRI. Blends were processed in a Wortex single screw extruder (L/D=32, at 230 °C and 50 rpm, using mass fractions of EOC in the range from 5% to 80%. The rheological properties were evaluated in steady and dynamic experiments at 190 °C and shear rates in the range from 90 s-1 to 1500 s-1 with frequencies from 10-1 s-1 to 10-2 s-1. The blends exhibited pseudoplasticity and complex rheological behavior. The complex rheological behavior was intensified with increasing molecular weight and long chain branching proportion (DRI in the EOC elastomers.

  2. Ingeniería de innovación aplicada a empresa productora de empaques flexibles en polietileno de alta y baja densidad y de propileno con impresión y sin impresión

    OpenAIRE

    Jesús David Castañeda A.; Alejandro Vásquez

    2006-01-01

    Este artículo tiene como finalidad presentar los resultados obtenidos al aplicar los métodos o técnicas de innovación determinados en la investigación Ingeniería de innovación para Pyme metalmecánica. La empresa escogida fabrica empaques flexibles de polietileno de alta y baja densidad y de polipropileno con impresión y sin impresión. El análisis se centra en dos variables que afectan significativamente el proceso y la productividad de la empresa: el desperdicio ...

  3. Compósitos de partículas de madeira de Eucalyptus grandis, polipropileno e polietileno de alta e baixa densidades Composites of Eucalyptus grandis wood, polypropylene, and high and low-density polyethylene particles

    Directory of Open Access Journals (Sweden)

    Emerson Gomes Milagres

    2006-06-01

    Full Text Available Este trabalho teve como objetivo determinar as propriedades de painéis fabricados com mistura de partículas de madeira de Eucalyptus grandis, polietileno de alta densidade, polietileno de baixa densidade e polipropileno. Empregaram-se duas formulações adesivas (uréia-formaldeído e uréia-formaldeído contendo 0,5% de epóxi. De modo geral, as propriedades dos painéis foram afetadas pela composição das partículas. Os painéis com melhores propriedades foram fabricados com 75% de partículas de madeira e 25% de partículas de polietileno de alta densidade. A adição de epóxi ao adesivo uréico aumentou os valores do módulo de ruptura, dureza Janka, e reduziu o inchamento, em espessura, de alguns painéis. As propriedades mecânicas da maioria dos painéis, exceto o módulo de elasticidade, ultrapassaram os valores mínimos estabelecidos na norma ANSI/A1-208/93.The objective of this work was to establish the properties of particleboards fabricated with blends of Eucalyptus grandis, low-density polyethylene, high-density polyethylene and polypropylene particles. Two adhesives formulations were used (urea-formaldehyde and urea-formaldehyde plus 0,5% of epoxy adhesive. Panel properties were affected by particle composition. Panels with best properties were fabricated with 75% of wood particles and 25% of high density polypropylene. The addition of epoxy to the urea-formaldehyde adhesive improved of the values of modulus of rupture, hardness and reduced the amount of thickness swelling. Except for the modulus of elasticity, board properties meet grade M-2 ANSI/A1-208/93 requirements.

  4. Consumo de alimentos de alta densidad energética en los beneficiarios del programa Oportunidades. El caso del Área Metropolitana de Monterrey

    Directory of Open Access Journals (Sweden)

    Óscar Alfonso Martínez Martínez

    2012-01-01

    refrescos y frituras, entre los beneficiarios y no beneficiarios de dicho programa. Se encontró que no existen diferencias estadísticamente significativas en su consumo, pero sí que las ingestas son altas para ambos grupos.

  5. Efecto del ejercicio en subpoblaciones de lipoproteínas de alta densidad y en la presión arterial

    OpenAIRE

    Nieto Cárdenas, Olga Alicia; García Cardona, Diana María; Jiménez, Jorge Alberto; Landázuri, Patricia

    2013-01-01

    Objetivo Determinar la relación del ejercicio con los niveles séricos de la apoA-I y las subpoblaciones de HDL2 y HDL3, en personas hipertensas de la Ciudad de Armenia - Quindío.Métodos La intervención fueron dos meses de ejercicio. La presión arterial se tomó con las recomendaciones del Ministerio de Salud de Colombia. Las subpoblaciones de HDL se midieron con el método del precipitado ionico y la apoA-I se midió con la técnica de nefelometría de bindig site.Resultados Los datos se analizaro...

  6. Modificação química de celulose para utilização em mistura com polietileno de alta densidade

    OpenAIRE

    Ciulik, Claudio Batista

    2010-01-01

    Resumo: O polietileno, um dos polímeros mais usados no mundo é também, um dos principais resíduos poliméricos encontrados nos lixões dos grandes centros urbanos. Este e outros problemas como a pequena resistência ao desgaste, alta transmissão de odores e baixa resistência à migração de óleos e gorduras, torna promissor o estudo de novas composições com este termoplástico, agregando ao mesmo, substâncias que enriqueçam suas propriedades tal como a celulose. Sabendo das grandes diferenças de pr...

  7. Movilización intracelular de colesterol mediada por apoA-I y dHDL: dominios proteicos involucrados

    OpenAIRE

    Cabaleiro, Laura Virginia

    2013-01-01

    La apoA-I cumple un rol muy importante en el transporte reverso del colesterol (TRC), es el componente mayoritario de las lipoproteínas de alta densidad (HDL) que desempeñan diversas funciones en las distintas etapas del TRC. Resultados previos de este laboratorio permiten postular la hipótesis de que la región central de la apoA-I, formada por el par de hélices tipo Y, estaría involucrada en la interacción con la membrana celular, que sería importante para el eflujo de lípidos y la movilizac...

  8. Compensatory growth of Malaysian prawns reared at high densities during the nursery phase Crescimento compensatório em camarões-da-malásia cultivados sob altas densidades durante a fase de berçário

    Directory of Open Access Journals (Sweden)

    H.L.A. Marques

    2011-04-01

    Full Text Available The objective of this work was to verify the occurrence of compensatory growth in Malaysian prawn (Macrobrachium rosenbergii reared in pens, after being stocked in cages under high densities during nursery phase. The experiment was carried out in 0.5 m² cages and 2-m² pens set in natural bottom pond with 2,400 m². Prawn post-larvae (PL with an average weight of 0.026 ± 0.012 g (nursery phase were initially stocked in 16 cages at the densities of 50, 400, 800 and 1,200 PL m-2. Sixty days later, prawns were transferred to 16 growing pens, at the density of 12 prawns m-2. Initial average weight of the prawn in this phase was the final average weight registered in the nursery phase, as follows: 50 PL m-2 = 2.3 ± 0.3 g; 400 PL m-2 = 0.5 ± 0.03 g; 800 PL m-2 = 0.3 ± 0.05 g and 1,200 PL m-2 = 0.1 ± 0.01 g. Commercial rations for prawns (35% crude protein were given once a day, in the afternoon. After 244 days, survival, average weight and biomass did not differ significantly among prawns with different initial average weight. Relative growth rate was significantly greater in prawns previously stocked at 1,200 PL m-2 and feed conversion efficiency was significantly better for those previously stocked at 400 and 1,200 PL m-2. These results suggest the existence of partial compensatory growth in M. rosenbergii, what can successfully carry on stocking of prawns of this species at high densities in the nursery phase.Este trabalho foi realizado com o objetivo de verificar a ocorrência de crescimento compensatório em camarões-da-malásia (Macrobrachium rosenbergii cultivados em cercados, após serem estocados em gaiolas sob altas densidades durante a fase de berçário. O experimento foi conduzido em gaiolas com 0,5 m² e cercados com 2 m² instalados em um viveiro de fundo natural com 2.400 m². Pós-larvas (PL de camarões com peso médio de 0,026 ± 0,012 g (fase de berçário foram inicialmente estocadas em 16 gaiolas, nas densidades de 50, 400

  9. ALTAS DENSIDADES DE PLANTIO NA CULTURA DO ABACAXI CV. SMOOTH CAYENNE, SOB CONDIÇÕES DE SEQUEIRO HIGH PLANTING DENSITY FOR THE SMOOTH CAYENNE PINEAPPLE CROP, GROWN UNDER RAINFED CONDITIONS

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    LUCIANA LIMA DE ALMEIDA SANTANA

    2001-08-01

    Full Text Available No Brasil têm-se usado densidades de plantio relativamente baixas para a obtenção de frutos grandes, com reflexos negativos na produtividade da cultura do abacaxi. No entanto, frutos cada vez menores têm sido comercializados no mercado internacional, o que poderá também ocorrer no mercado nacional. Este trabalho teve o objetivo de avaliar o efeito de altas densidades em sistemas de plantio em filas duplas sobre a produção quantitativa e qualitativa de abacaxi cv. Smooth Cayenne, sob condições de sequeiro. Densidades de plantio, variando de 51.280 plantas/ha a 100.000 plantas/ha, foram estudadas em delineamento experimental de blocos casualizados, com cinco repetições e doze tratamentos, distribuídos em esquema fatorial 4 x 3, correspondendo a quatro combinações de espaçamentos entre linhas duplas e entre linhas simples na fila dupla (90cm x 40 cm, 90 cm x 30 cm, 80 cm x 30 cm , 70 cm x 30 cm e três espaçamentos entre plantas nas linhas de plantio (30 cm, 25 cm, 20 cm. A análise de variância determinou diferença estatística apenas para a produtividade, em função do espaçamento entre plantas na linha de plantio, sendo mais elevada para o espaçamento de 20 cm. O peso do fruto, as suas dimensões e a sua qualidade (açucares, acidez, teor de suco, relação açúcares/acidez não foram significativamente influenciados pelas densidades de plantio estudadas, mantendo-se dentro dos padrões da cultivar. Para cada aumento de 10.000 plantas por hectare, a produtividade cresceu em 8,27 t/ha e o peso médio do fruto caiu 102 g. Nas condições ambientais dos Tabuleiros Costeiros do Norte da Bahia, a cultura do abacaxi cv. Smooth Cayenne apresenta potencial para uso em altas densidades de plantio, mesmo em cultivo de sequeiro, podendo-se atingir produtividade acima de 80t/ha e peso médio do fruto superior a 1,0 kg.In Brazil, relatively low planting densities have been used to obtain large fruits, with negative effects on pineapple

  10. Concentração plasmática de colesterol total e lipoproteína de alta densidade em novilhas mestiças doadoras de embriões tratadas com somatotropina bovina recombinante Total plasma cholesterol and high-density lipoprotein levels in crossbred heifer embryo donors treated with bovine recombinant somatotropin

    Directory of Open Access Journals (Sweden)

    Á.M. Borges

    2001-10-01

    Full Text Available O objetivo do experimento foi o de estudar as concentrações plasmáticas de colesterol total e lipoproteína de alta densidade (HDL em novilhas mestiças tratadas com somatotropina bovina recombinante (rbST. Coletas de sangue foram feitas durante dois ciclos estrais, normal e superovulado, em 26 fêmeas distribuídas em dois tratamentos: T1 = aplicação de 500mg de rbST no terceiro dia do ciclo estral utilizado para a superovulação e T2 = controle. Análises dos metabólitos sangüíneos foram feitas utilizando-se o método enzimático, cujas concentrações médias plasmáticas de colesterol total e de HDL durante o ciclo estral normal não foram diferentes (P>0,05 entre os dois tratamentos: 87,9 e 25,8mg/dl e 85,9 e 26,7mg/dl para T1 e T2, respectivamente. O ciclo estral utilizado para a superovulação foi dividido em três períodos: P1 = do estro à inseminação artificial (0 ao15º dia, P2 = da inseminação artificial até a coleta de embriões (15º ao 21º dia e P3 = da coleta até o final do período experimental (21º ao 27º dia. As concentrações plasmáticas de colesterol total e HDL no P1 não diferiram entre os tratamentos (P>0,05. Em P2 e P3 houve diferença nas concentrações de HDL e colesterol total entre os dois tratamentos: 29,0 e 88,5mg/dl (T1 e 27,1 e 81,8mg/dl (T2 no P2; e 30,4 e 88,0mg/dl (T1 e 26,6 e 80,5mg/dl (T2 no P3, respectivamente (PThe objective of the experiment was to study the total cholesterol and high-density lipoprotein (HDL levels in crossbred heifers treated with bovine recombinant somatotropina (rbST. Blood samples were collected for two estrous cycles, normal and superovulated, from 26 animals randomly distributed into two treatments: T1 - injected with 500mg rbST on day 3 of estrous cycle and T2 - control. The lipidic metabolite levels were determined by an enzymatic method, and plasma levels of total cholesterol and HDL in normal estrous cycle did not differ (P>0.05 between treatments: 87

  11. Polietileno de Alta Densidade Tenacificado com Elastômero Metalocênico: 1. Propriedades Mecânicas e Características Morfológicas Rubber Toughened High Density Polyethylene: 1. Mechanical Properties and Morphological Characteristics

    Directory of Open Access Journals (Sweden)

    Maria José O. C. Guimarães

    2002-01-01

    Full Text Available Neste trabalho foram estudadas as propriedades mecânicas e morfológicas de polietileno de alta densidade (HDPE tenacificado com dois tipos de elastômeros metalocênicos à base de etileno/1- octeno (EOC. Esses elastômeros são polímeros comerciais com diferenças quanto ao peso molecular, índice de fluidez e índice Dow de reologia (DRI. Misturas físicas de HDPE e EOC foram processadas em extrusora monorosca Wortex (L/D=32, à 230°C e 50 rpm, utilizando percentagem mássica do EOC de 5% a 80%. Foi observado um efeito sinergístico nas propriedades tênseis e características de supertenacificação para materiais contendo proporções do EOC maiores do que 5%. Cavitação, deformação plástica e cavitação fibrilada foram observados nos processos de deformação. Materiais contendo até 50% do EOC apresentaram morfologias dispersas com domínios elastoméricos esféricos, distribuídos uniformemente e com tamanho médio de partícula na faixa de 0,30 a 0,45 µm. A tenacificação de HDPE com os elastômeros etilênicos produziu materiais com boas propriedades e compatibilização tecnológica devido à existência de baixa tensão interfacial entre esses polímeros.The mechanical and morphological properties of high density polyethylene (HDPE toughened with two different grades of metallocene elastomers based on ethylene/1- octene (EOC were studied. These elastomers were commercial polymers differing in molecular weight, melt flow index and Dow rheology index (DRI. Blends were processed in a Wortex single screw extruder (L/D=32, at 230°C and 50 rpm, using mass fraction weight percent of EOC in the range from 5% to 80%. A synergistic effect on the tensile properties and supertough behavior for blends with EOC concentrations higher than 5% was observed. Cavitation, plastic deformation and fibrillized cavitation were observed in the deformation processes. Materials containing up to 50% of EOC exhibited dispersed morphologies with EOC

  12. Fertilización de base en un cultivo inicial de pecan con dos marcos de plantación de alta densidad Effect of different fertilization strategies on pecan growth parameters under two high density plantation frames

    Directory of Open Access Journals (Sweden)

    Lidia Giuffré

    2011-07-01

    Full Text Available El pecán, Carya illinoensis Koch, es una especie cuyo fruto es reconocido como un alimento altamente saludable. Su cultivo se encuentra en expansión en la Argentina pero existen muy pocas investigaciones sobre fertilización y sistemas de plantación. Los objetivos del trabajo fueron caracterizar algunas propiedades físico-químicas y químicas de un suelo en el que se inicia un cultivo de pecán, y comparar tratamientos de fertilización de base (FB en dos marcos de plantación de alta densidad (MP. Se realizó una plantación de pecán en Villanueva (provincia de Buenos Aires, sobre un suelo Hapludol taptoárgico, con dos marcos de plantación: 10 x 10 m (marco real: MR y 8 x 8 m (tresbolillo: TR. El diseño del experimento fue en parcelas divididas con cuatro repeticiones. La parcela principal fueron los dos marcos de plantación, y las subparcelas fueron los distintos tratamientos de fertilización base: Compost (C, Fósforo (P, Nitrógeno (N y Control sin fertilización base (T. Las determinaciones para evaluar el crecimiento de las plantas de pecán fueron: la altura de las plantas y el diámetro del tronco. Con respecto a la fertilidad del suelo, la fertilización fosforada y el agregado de compost permitieron aumentar significativamente los niveles de P-Bray. El tratamiento con fertilización orgánica: compost, presentó un incremento significativo en altura de los pecanes en el marco de plantación 8 x 8 m, que no se manifestó en ningún caso en los diámetros del tronco, con una interacción MP x FB significativa (P=0,01 para la variación de altura al primer año. La variación del volumen del árbol durante el año de experimentación no presentó efectos significativos según el marco de plantación ni la fertilización base aplicada.The fruit of the pecan tree, Carya illinoensis Koch, is considered a very healthy food. In Argentina, pecan cultivation has been expanding rapidly but very little research has been conducted on

  13. HDL Cholesterol Test

    Science.gov (United States)

    ... limited. Home Visit Global Sites Search Help? HDL Cholesterol Share this page: Was this page helpful? Also ... HDL; HDL-C Formal name: High-density Lipoprotein Cholesterol Related tests: Cholesterol ; LDL Cholesterol ; Triglycerides ; Lipid Profile ; ...

  14. Rejuvenecimiento de manos con ácido hialurónico de alta densidad: estudio prospectivo en 29 pacientes Hands rejuvenation with high density hyaluronic acid: prospective study in 29 patients

    Directory of Open Access Journals (Sweden)

    J.M. Alcolea

    2012-12-01

    Full Text Available El objetivo del presente estudio prospectivo es valorar a corto, medio y largo plazo, la eficacia en el rejuvenecimiento de las manos de la inyección subcutánea de ácido hialurónico (AH, Macrolane® 20, de alta densidad y partículas grandes, teniendo en cuenta el beneficio del tratamiento, la satisfacción de los pacientes y las posibles complicaciones. Este estudio se realizó entre mayo del 2010 y diciembre del 2011. Se seleccionaron 29 pacientes al azar entre 51 y 74 años de edad con fototipos II a IV, a los que se les inyectó AH para rejuvenecer las manos. La cantidad de AH inyectada en cada mano fue de 1 a 2 ml. Se realizaron controles sistemáticos en la 2ª semana, en los meses 1º, 3º, 6º, 9º y 12º. Se tuvieron en cuenta las complicaciones en cada paciente en todos los controles. En el primer control, en la 2ª semana, junto al examen clínico se practicó examen ecográfico a fin de determinar si sería necesaria una segunda inyección de AH. En cada uno de los controles los pacientes contestaron a un formulario para indagar sobre su grado de satisfacción con el tratamiento. Solo 1 paciente presentó edema y 3 tuvieron equimosis leve; 2 pacientes manifestaron dolor leve con las inyecciones y 2 requirieron una segunda inyección tras la valoración en la 2ª semana. La satisfacción de los pacientes en los controles superó la valoración clínica y fotográfica. En nuestra opinión, el rejuvenecimiento de las manos con este tipo de AH de grandes partículas tiene una baja tasa de complicaciones y es bien tolerado, con un alto grado de satisfacción por parte de los pacientes y una notable mejoría de los parámetros estudiados: arrugas, aspecto de la atrofia dérmica y subcutánea y disminución de los relieves óseos, tendinosos y venosos. La valoración tanto subjetiva como objetiva se hizo hasta el año de seguimiento con buenos resultados.The aim of this prospective study is to assess the efficacy of a high density

  15. Avaliação do efeito de um óleo parafínico sobre o comportamento físico-químico de tubulações de polietileno de alta densidade Evaluation of the effect caused by a paraphinic oil on the physicochemical behavior of high-density polyethylene pipes

    OpenAIRE

    Amélia A. U. Torres; José Roberto M. d'Almeida; Jean-Pierre Habas

    2010-01-01

    Nesse trabalho são investigados os efeitos causados por um óleo parafínico sobre o comportamento físico-químico de dutos de polietileno de alta densidade (PEAD). Os efeitos causados nos dutos de PEAD foram avaliados em função do tempo e da temperatura de exposição através de análises gravimétrica e termogravimétrica e por espectroscopia no infravermelho. Os dados gravimétricos puderam ser satisfatoriamente descritos pela Lei de Fick. Os resultados de FTIR indicaram que não ocorreram modificaç...

  16. Metodología para el diseño de diagnósticos interferométricos de alta resolución espacial para la medida de perfiles de densidad electrónica en plasmas de fusión: el interferómetro heterodino de haz expandido y de dos longitudes de onda del Stellarator TJ-II

    OpenAIRE

    Pedreira Conchado, Pablo

    2011-01-01

    Este trabajo de tesis doctoral desarrolla una metodología para el diseño de diagnósticos interferométricos multicanal para la medida de perfiles de densidad electrónica de alta resolución espacial en plasmas de fusión confinados magnéticamente y su validación a través del diseño de un diagnóstico para el stellarator TJ-II. A mediados del siglo XX surge la fusión termonuclear como una solución y alternativa a los problemas que se derivan del uso de los combustibles fósiles co...

  17. Patella Alta

    OpenAIRE

    Cakmak, Mehmet; Taser, Omer; Karamehmetoglu, Mahmut; Domanic, Unsal

    2004-01-01

    Patella alta is investigated with Insall-Salvati method in lateral X-rays obtained with the knee in 30 flexion in 26 cases with recurrent dislocation of the patella and in 16 cases diagnosed to have chondromalasia. Patella alta is identified in 12 cases with recurrent dislocation of patella and in 9 cases with chondromalasia. Patella alta, which is one of the significaint consative agents of patella femoral instrability, is reviewed under the literature data.

  18. High population density survival of the sea urchin Diadema antillarum (Philippi 1845 to a category 5 hurricane in southern Mexican Caribbean Supervivencia de una alta densidad poblacional del erizo de mar Diadema antillarum (Philippi 1845 a un huracán categoría 5 en el sur del Caribe mexicano

    Directory of Open Access Journals (Sweden)

    Pablo Jorgensen

    2008-12-01

    Full Text Available The vulnerability of the sea urchin Diadema antillarum to the impact of the category 5 hurricane "Dean" was assessed at a back-reef area of Mahahual (Southern Mexican Caribbean. Seventy days after Dean, there was a high mean Diadema population density of 12.6 ± 4.3 (SD; from here forward ind m-2, with a large mean individual test diameter of 59.2 ±9.8 mm. This population was comparable to a previous report for the same area, just before the landfall of Dean on 21 August 2007. Immigration of adults from deeper fore-reef sites after Dean across the reef-crest was unlikely, considering the homing behavior displayed by tagged urchins. The degree of physical alteration of the habitat indicated that Diadema may survive higher hurricane-generated disturbances than those reported in previous works. These results have strong implications on the conservation of the Mexican Caribbean coral reefs since the Diadema populations surveyed have a high grazing activity and are persistent against hurricanes impact.La vulnerabilidad del erizo de mar Diadema antillarum al impacto del huracán categoría 5 "Dean" fue evaluada en el arrecife posterior de Mahahual, México. Setenta días después de la recalada de Dean fue estimada una alta densidad media poblacional de Diadema de 12.6 ind m-2 (DE = 4.3, con un elevado tamaño individual promedio de 59.2 mm de diámetro (DE = 9.8. Esta densidad fue comparable a la de un reporte previo para la misma zona, días antes del paso de Dean el 21 de agosto de 2007. Considerando la fidelidad al refugio mostrado por erizos marcados, la inmigración de adultos desde el arrecife anterior después del paso de Dean fue poco factible. El nivel de destrucción del hábitat indica que Diadema sería más persistente al impacto directo de huracanes que lo sugerido por estudios anteriores. Debido al elevado potencial de pastoreo de las poblaciones locales de Diadema, y a su persistencia al impacto de huracanes, los resultados de este

  19. Cultivos de alta densidad celular por retención interna: aplicación a la fermentación continua de etanol High cell density cultures produced by internal retention: application in continuous ethanol fermentation

    Directory of Open Access Journals (Sweden)

    Godoy Rubén Darío

    2004-12-01

    Full Text Available El etanol ha generado gran interés por su potencial como combustible alternativo. No obstante, para que este producto sea competitivo económicamente, es necesario desarrollar procesos de fermentación que incrementen la baja productividad volumétrica lograda en cultivos convencionales (por lote o continuo, por medio de técnicas que permitan altas concentraciones celulares y reduzcan la inhibición por producto. Uno de los métodos empleados frecuentemente involucra la recirculación celular; por ello, en este trabajo se desarrolló un reactor de membrana incorporando un módulo de filtración, con unidades tubulares de 5 u,m en acero inoxidable, dentro de un fermentador de tanque agitado de 3L, para investigar su aplicación en la producción continua de etanol. Los efectos de la concentración celular y la caída de presión transmembranal sobre el flux de permeado fueron evaluados para probar el desempeño del módulo de filtración. Previa selección de las condiciones de fermentación (30 °C, 1,25 -1,75 vvm, pH 4,5, el sistema con retención celular interna fue operado en el cultivo continuo de Saccharomyces cerevisiae a partir de sacarosa. La permeabilidad de las unidades filtrantes fue mantenida mediante la aplicación de pulsos de aire. Más del 97% de las células cultivadas fueron retenidas en el fermentador, alcanzándose una concentración celular de 51 g/L y una productividad promedio de etanol, en el cultivo con retención celular, de 8,51 g/L.h, la cual fue dos veces mayor a la que se obtiene en un cultivo continuo convencional. Palabras clave: reactor de membrana, Saccharomyces cerevisiae, fermentación alcohólica, recirculación celular.Ethanol has provoked great interest due to its potential as an alternative fuel. Nevertheless, fermentation processes must be developed by increasing the low volumetric productivity achieved in conventional cultures (batch or continuous to make this product become economically competitive

  20. Avaliação do efeito de um óleo parafínico sobre o comportamento físico-químico de tubulações de polietileno de alta densidade Evaluation of the effect caused by a paraphinic oil on the physicochemical behavior of high-density polyethylene pipes

    Directory of Open Access Journals (Sweden)

    Amélia A. U. Torres

    2010-01-01

    Full Text Available Nesse trabalho são investigados os efeitos causados por um óleo parafínico sobre o comportamento físico-químico de dutos de polietileno de alta densidade (PEAD. Os efeitos causados nos dutos de PEAD foram avaliados em função do tempo e da temperatura de exposição através de análises gravimétrica e termogravimétrica e por espectroscopia no infravermelho. Os dados gravimétricos puderam ser satisfatoriamente descritos pela Lei de Fick. Os resultados de FTIR indicaram que não ocorreram modificações estruturais importantes no PEAD exposto a esse óleo e que o processo de envelhecimento do PEAD foi do tipo físico, já que nenhuma alteração na estrutura química do polímero foi detectada.The effects caused by a paraphinic oil on the physicochemical behavior of high-density polyehtylene pipes were investigated, as a function of time and temperature. These effects were evaluated by thermogravimetric and gravimetric analysis and by FTIR. The gravimetric data were satisfactorily described using the Fick's law, and the FTIR results showed that no main structural modifications have occurred after exposure of the HDPE pipes to this oil. From the results obtained it was concluded that physical aging was occurring, since the chemical structure of the polymer was not altered.

  1. HDL: More Than Just Cholesterol

    Directory of Open Access Journals (Sweden)

    Anna Meilina

    2010-12-01

    Full Text Available BACKGROUND: Plasma concentration of high density lipoprotein cholesterol (HDL-C are strongly, consistenly, and independently inversely associated with risk of atheroschlerotic cardiovascular disease (CVD. However, the last decade has seen several observations that do not follow this simple script. CONTENT: A proteomic analysis of HDL has given us an intriguing glimpse into novel components of HDL. HDL isolated from normal humans contains several classes of proteins, including not only apolipoproteins, but also complement regulatory proteins, endopeptidase inhibitors, hemopexin, and acute phase response proteins. These observations raise the possibility of unsuspected roles for HDL. HDL delivery of complement proteins would implicate HDL in innate immunity. Serine proteinase inhibitors would enable HDL to modulate proteolysis of the vessel wall. HDL from patients with coronary artery disease was enriched in apoE, apoC-IV, apoA-IV, Paraoxonase (PON, and complement factor C3. Highlighted additional mechanisms through which HDL protects the vessel wall are: HDL improves vascular function, decreases vascular inflammation, detoxifies radicals, and limits thrombosis. SUMMARY: Both inter- and intra-organ desynchrony may be involved in the pathogenesis of cardiometabolic disease attributable to effects in brain and multiple metabolic tissues including heart, liver, fat, muscle, pancreas, and gut. Efforts to dissect the molecular mediators that coordinate circadian, metabolic, and cardiovascular systems may ultimately lead to both improved therapeutics and preventive interventions. KEYWORDS: HDL, Apo–A1, RCT, inflammation, HDL dysfunction, HDL proteome, HDL & Apo-A1 mimetics.

  2. High density of defoliated tomato plants in protected cultivation and its effects on development of trusses and fruits Alta densidade com desfolhamento de plantas de tomateiro em cultivo protegido e seus efeitos sobre o desenvolvimento de inflorescências e frutos

    Directory of Open Access Journals (Sweden)

    Miguel A. Sandri

    2002-09-01

    ground area seems to be the upper limit in maximizing the number of set fruits of this crop.O número de frutos em plantas de tomateiro cultivadas em alta densidade e com índice de área foliar similar mantido através de desfolhamento foi determinado em três condições ambientais, no interior de túneis de polietileno. O experimento 1 foi conduzido no outono, com radiação solar média recebida pela cultura de 8,0 MJ m-2 dia-1 e temperatura média exterior de 18,1ºC. Os experimentos 2 e 3 foram conduzidos na primavera, com temperatura média exterior de 19,7ºC. No experimento 2, a radiação solar média recebida pela cultura foi de 12,4 MJ m-2 dia-1, enquanto no experimento 3 foi reduzida para 5,9 MJ m-2 dia-1 por meio de uma tela com 52% de sombreamento. As plantas foram cultivadas em sacolas, com 1,0 m entre fileiras e 0,3 m entre sacolas, enchidas com 5,5 L de substrato comercial. Nutrientes e água foram fornecidos via solução nutritiva, de forma a repor os volumes perdidos pela transpiração. Os tratamentos consistiram de uma (T1, duas (T2 e três (T3 plantas por sacola, correspondendo a densidades de 3,3; 6,7 e 10 plantas m-2, respectivamente. Em T1, três folhas por simpódio foram mantidas, com uma proporção de 3:1 entre o número de folhas e de inflorescências, em cada simpódio. Em T2, duas e uma folha foram mantidas respectivamente em dois simpódios consecutivos, alternativamente em ambas as plantas da sacola. A relação entre o número de folhas e de inflorescências foi de 3:2. Em T3, com três plantas por sacola, somente uma folha por simpódio foi mantida, com uma relação de 3:3. Em todos os experimentos, o número de inflorescências por unidade de área em T2 e T3 foi duas e três vezes maior que em T1, respectivamente. O número de frutos fixados por área de solo foi menor em T1 e similar em T2 e T3 no primeiro experimento, enquanto no segundo e terceiro experimentos valores similares foram observados entre os tratamentos. Os

  3. HDL, Atherosclerosis, and Emerging Therapies

    OpenAIRE

    Anouar Hafiane; Jacques Genest

    2013-01-01

    This review aims to provide an overview on the properties of high-density lipoproteins (HDLs) and their cardioprotective effects. Emergent HDL therapies will be presented in the context of the current understanding of HDL function, metabolism, and protective antiatherosclerotic properties. The epidemiological association between levels of HDL-C or its major apolipoprotein (apoA-I) is strong, graded, and coherent across populations. HDL particles mediate cellular cholesterol efflux, have antio...

  4. Substituição da fibra de vidro por fibra de bananeira em compósitos de polietileno de alta densidade: parte 1. Avaliação mecânica e térmica Mechanical and thermal behavior of composites based on high density polyethylene and banana tree fiber

    Directory of Open Access Journals (Sweden)

    Thiago S. Gomes

    2013-01-01

    Full Text Available A utilização de resíduo de fibra natural em substituição à fibra de vidro foi avaliada. Foram estudados compósitos de polietileno de alta densidade, HDPE, e fibra de bananeira com 10, 20, 30 e 40% (m/m de fibra. Compósitos com fibra de vidro, mesma matriz polimérica e nas mesmas proporções, foram preparados para comparação. Os compósitos foram obtidos em extrusora dupla-rosca co-rotacional interpenetrante e os corpos de prova foram preparados por injeção. As propriedades mecânicas sob tração, flexão e impacto foram avaliadas. As propriedades térmicas foram analisadas por calorimetria diferencial de varredura (DSC e análise termogravimétrica (TG. A incorporação de fibra de bananeira no HDPE resultou no aumento de cristalinidade do polímero. Houve, também, considerável aumento no grau de reforço mecânico nos compósitos pela incorporação da fibra natural. Foi possível comprovar a substituição da fibra de vidro pela fibra de bananeira em determinados percentuais, quando misturados ao HDPE, sem prejuízo às propriedades. A análise termogravimétrica dos compósitos mostrou que o início de degradação se deu numa faixa de temperatura intermediária entre a da fibra e a da matriz polimérica.The use of banana tree fiber instead of glass fiber in polyethylene composites was evaluated. Composites of high density polyethylene with 10, 20, 30 and 40 wt. % of banana fiber were investigated. For comparison, composites with glass fiber, with the same polymeric matrix and proportions, were prepared. The samples were produced using an intermeshing co-rotating twin-screw extruder and injection molding. The mechanical properties investigated were the tensile, flexural and impact resistances of the composite. Thermal analyses were carried out by differential scanning calorimetry (DSC and thermogravimetry (TG. The incorporation of fiber resulted in an increase in the composite degree of crystallinity. A considerable increase

  5. Preparação e caracterização de biocompósitos baseados em fibra de curauá, biopolietileno de alta densidade (BPEAD e polibutadieno líquido hidroxilado (PBHL Preparation and characterization of biocomposites based on curaua fibers, high-density biopolyethylene (HDBPE and liquid hydroxylated polybutadiene(LHPB

    Directory of Open Access Journals (Sweden)

    Daniele O. Castro

    2013-01-01

    Full Text Available Neste trabalho, foram utilizadas fibras de curauá como reforço de matriz termoplástica de biopolietileno de alta densidade. O polietileno foi obtido por polimerização de eteno, gerado do etanol de cana de açúcar. Este polímero é também chamado de biopolietileno (BPEAD, por ser preparado a partir de material oriundo de fonte natural. Desta forma, pretendeu-se contribuir para desenvolver materiais que, dentre outras propriedades, causem menor emissão de CO2 para a atmosfera na sua produção, utilização e substituição, comparativamente a outros materiais. Adicionalmente, polibutadieno líquido hidroxilado (PBHL foi acrescentado à formulação do compósito, visando a um aumento na resistência à propagação da trinca durante impacto. Os compósitos e as fibras foram caracterizados por várias técnicas, tais como microscopia eletrônica de varredura (MEV, Calorimetria Exploratória Diferencial (DSC, Termogravimetria (TG, além da caracterização dos compósitos quanto à Análise Térmica Dinâmico-Mecânica (DMTA, propriedades mecânicas (impacto e flexão e absorção de água. A presença das fibras de curauá diminuiu algumas propriedades do BPEAD, como resistência ao impacto. A análise de DMTA mostrou que as fibras geram material mais rígido. Pode-se considerar que a introdução de PBHL na formulação do material foi eficiente, levando a uma resistência ao impacto do compósito BPEAD/PBHL/Fibra maior do que a do compósito BPEAD/Fibra.In this work, curaua fibers were used in the reinforcement of a high-density (HDPE thermoplastic matrix. The polyethylene used was obtained by polymerization of ethene produced from sugarcane ethanol. This polymer, also called high-density biopolyethylene (HDBPE, was prepared from a natural source material. The aim was to contribute to developing materials which could lead to smaller release of CO2 into the atmosphere in comparison to other materials. Additionally, liquid

  6. to HDL-cholesterol functionality

    Directory of Open Access Journals (Sweden)

    Malara Marzena

    2016-05-01

    Full Text Available The purpose of this study was to analyse the scientific evidence concerning the effects of two enzymes – paraoxonase 1 and myeloperoxidase – on the functions of HDL-cholesterol. It is well documented that disturbed circulating lipoproteins (a high total and high LDL-cholesterol, and low HDL-cholesterol bring about atherosclerosis and an increased risk of cardiovascular disease (CVD which is recognised as the main cause of death all around the world. In consequence, numerous studies have focused on procedures which will improve the plasma lipoproteins profile by decreasing the total cholesterol and the LDL-cholesterol (LDL-C and increasing the HDL-cholesterol (HDL-C. However, the anti-atherogenic role of HDL-C has been challenged in studies showing that genetically elevated HDL-cholesterol does not offer protection against CVD. Moreover, it has been found that raising the circulating HDL-cholesterol fails to reduce atherosclerosis. The doubts concerning the protective role of HDL-C have been supported by in vitro studies which indicate that the HDL-C from patients with atherosclerosis does not have a protective action, but does stimulate inflammation and free radical synthesis. The above data suggests that HDL-C, commonly recognised as protective against atherosclerosis, in some circumstances becomes pro-atherogenic, and is thus dysfunctional. Our review focuses on two enzymes – paraoxonase 1 (PON1 and myeloperoxidase (MPO – which markedly affect the properties of HDL-C and contribute to its anti – or pro-atherogenic activity. Moreover, the effects of the diet and physical activity on PON1 and MPO are summarised with respect to the HDL-C functionality.

  7. 77 FR 29633 - Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC...

    Science.gov (United States)

    2012-05-18

    ... Energy Regulatory Commission Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC... Practice and Procedure, 18 CFR 385.207, Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind... to firm transmission rights to the capacity of three transmission lines to be constructed by Alta...

  8. HDL cholesterol: atherosclerosis and beyond

    OpenAIRE

    Stroes, E. S. G.; Hovingh, G. K.; Kuivenhoven, J. A.; Bochem, A.E.

    2013-01-01

    Cardiovascular disease (CVD) is the leading cause of death in the Western world. Myocardial infarction and stroke are the result of a compromised blood flow which may result from cholesterol accumulation in the vessel wall due to high plasma levels of LDL cholesterol. High plasma levels of HDL cholesterol, however, are inversely associated with CVD. This is commonly ascribed to a concept called "reverse cholesterol transport" a mechanism by which the HDL particle takes up cholesterol from the...

  9. Efecto de la densidad en el crecimiento de juveniles tempranos de Cherax quadricarinatus (Decapoda: Parastacidae

    Directory of Open Access Journals (Sweden)

    M. C. Gallo-García

    2012-01-01

    Full Text Available En un estudio de cuatro semanas, se evaluó el efecto de tres densidades (134, 178, 223 org/ m2 sobre el crecimiento y supervivencia de juveniles tempranos (0.05 ± 0.02 g de Cherax quadricarinatus cultivados en un sistema de recirculación. Se alcanzaron pesos húmedos de 0.62 a 0.64 g, con tallas de 30.59 a 31.11 mm de longitud total y una supervivencia promedio final de 68%, sin diferencias significativas en los parámetros productivos de las diferentes densidades (p> 0.05. Los resultados sugieren la posibilidad de obtener buenos rendimientos durante el primer mes de cultivo a densidades tan altas como 223 org/m2 en un sistema de recirculación.

  10. Evaluación de los métodos directo, precipitado y Friedewald para la cuantificación de colesterol LDL y HDL en pollos de engorde

    OpenAIRE

    José Henry Osorio; Jancy Darly Flórez; Jorge Enrique Pérez

    2012-01-01

    El objetivo fue evaluar los métodos directo y precipitado para el colesterol de las lipoproteínas de alta densidad y los métodos directo, precipitado y Friedewald para el colesterol de las lipoproteínas de baja densidad en pollos de engorde. Se obtuvo suero de 30 pollos de engorde de 36 días de edad, en ayunas, de la línea Cobb 500, se determinaron los niveles de triglicéridos y colesterol total usando un kit enzimático-colorimétrico. El colesterol, tanto de las lipoproteínas de alta densidad...

  11. Filamentos elásticos de elastolefina de alta durabilidad obtenidos a partir de copolímeros de bloque de etileno-octeno de baja densidad mediante la tecnología de polimerización por transferencia de cadena para aplicaciones en indumentaria de uso profesional

    OpenAIRE

    Verdú Blasco, Pau

    2010-01-01

    En la actualidad el mercado carece de prendas elásticas para uso profesional puesto que los elastanos habitualmente utilizados son inestables frente a altas temperaturas y químicos agresivos, e.g. termofijado, mantenimiento de indumentaria industrial etc. Recientemente se han venido utilizado filamentos olefínicos obtenidos a partir de copolímeros al azar de etileno-octeno (Dow XLA fibers producidos por The Dow Chemical Company). Aunque más resistentes a las temperaturas...

  12. MATÉRIA SECA E ABSORÇÃO DE NUTRIENTES EM FUNÇÃO DO ESPAÇAMENTO E DA DENSIDADE DE SEMEADURA EM ARROZ DE TERRA ALTA DRY MATTER AND NUTRIENT UPTAKE OF DRYLAND RICE RELATED TO ROW SPACING AND PLANT POPULATION

    Directory of Open Access Journals (Sweden)

    Carlos Alexandre Costa Crusciol

    1999-01-01

    Full Text Available Foi instalado um experimento em condições de campo, em um Latossolo Vermelho escuro, epi-eutrófico, textura argilosa, em Selvíria-MS, com arroz de sequeiro cv. IAC 201, estudando-se três espaçamentos entre fileiras (30, 40 e 50 cm e três densidades de semeadura (100, 150 e 200 sementes viáveis/m2. Foram avaliadas a produção de matéria seca da parte aérea no momento do florescimento e determinados os teores e quantidades de N, P, K, Ca, Mg e S absorvidos, assim como a eficiência de utilização de nutrientes. A redução do espaçamento entre fileiras aumentou a produção de matéria seca da parte aérea e a quantidade de nutrientes absorvidos. A variação da densidade de semeadura não afetou os parâmetros estudados. A redução do espaçamento entre fileiras proporcionou maior eficiência de utilização do Ca e diminuiu a do N e Mg. Os teores de nutrientes na matéria seca da parte aérea não foram afetados pela variação do espaçamento entre fileiras.A field experiment was conducted in a clayey Dark Red Latosol in Selviria, MS, Brazil, to study the effect of three row spacings (30, 40 and 50 cm and three seed densities (100, 150 and 200 viable seeds/m2 on plant dry matter yield, macronutrient (N, P, K, Ca, Mg and S uptake at flowering, and the nutrient use efficiency. A decrease in row spacing led to an increase in shoot dry matter production and nutrient uptake. There was no effect of plant densities on dry matter or nutrient uptake. The decrease in row spacing allowed a higher Ca use efficiency, but not for N and Mg. The concentration of the macronutrients in the shoots was not affected by spacing.

  13. DENSIDADE DE SEMEADURA E PRODUTIVIDADE DO PORONGO

    Directory of Open Access Journals (Sweden)

    Dilson Antônio Bisognin

    1992-04-01

    Full Text Available O trabalho teve como objetivo determinar a melhor densidade de semeadura para a cultura do porongo Lagenaria siceraria (Mol. Standi. Foi realizado um experimento na Universidade Federal de Santa Maria -RS, em 1987-88, com densidades de 2.222; 2.500; 2.666; 3.333 e 4.444 covas/ha, sendo avaliada a produção de frutos industrializáveis (número de frutos/ha e número de frutos/cova. Em outro experimento, instalado em Restinga Seca-RS, em 1988-89, usou-se densidades de 1.111, 2.222, 3.333, 4.444, 5.555 e 6.666 covas/ha, sendo avaliadas a produção de frutos industrializáveis, número de nós na ramificação primária (nós/planta, espessura do casco e volume externo da cuia O delineamento experimental foi blocos ao acaso com quatro repetições e duas plantas por cova, nos dois experimentos. Os resultados de produtividade não mostraram relação com as diferentes densidades estudada?, mas os melhores resultados foram obtidos com densidades que variaram de 3.333 à 5.555 covas por hectare. O número de frutos/cova, nós/planta e a espessura do casco diminuíram à medida que aumentou a densidade de semeadura Em densidades menores a produtividade foi compensada pelo aumento do número de frutos por cova O aumento da densidade de semeadura diminuiu o volume externo da cuia.

  14. The role of dysfunctional HDL in atherosclerosis

    OpenAIRE

    Navab, Mohamad; Reddy, Srinivasa T.; Van Lenten, Brian J.; Anantharamaiah, G. M.; Fogelman, Alan M

    2009-01-01

    This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.

  15. Emerging therapeutic strategies to enhance HDL function

    Directory of Open Access Journals (Sweden)

    Urraca Concha

    2011-10-01

    Full Text Available Abstract Epidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL and cardiovascular disease (CVD. The most relevant cardioprotective mechanism mediated by HDL is thought to be reverse cholesterol transport (RCT. New insights in HDL biology and RCT have allowed the development of promising agents aimed to increase HDL function and promote atherosclerosis regression. In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD.

  16. Altas capacidades e interdisciplinariedad

    OpenAIRE

    Moreno-García, María José

    2013-01-01

    El presente trabajo fin de grado trata de abordar la importancia de dar una respuesta educativa acorde a las necesidades del alumnado de altas capacidades. Para ello, primeramente, se ha visto necesario definir el término de altas capacidades, analizar sus características, matizar la importancia de su detección temprana, desbancar falsos mitos y conocer la legislación vigente al respecto, para posteriormente elaborar una propuesta de intervención, que se ha llevado a cabo en el Colegio Nelva,...

  17. HDL to verification logic translator

    Science.gov (United States)

    Gambles, J. W.; Windley, P. J.

    1992-01-01

    The increasingly higher number of transistors possible in VLSI circuits compounds the difficulty in insuring correct designs. As the number of possible test cases required to exhaustively simulate a circuit design explodes, a better method is required to confirm the absence of design faults. Formal verification methods provide a way to prove, using logic, that a circuit structure correctly implements its specification. Before verification is accepted by VLSI design engineers, the stand alone verification tools that are in use in the research community must be integrated with the CAD tools used by the designers. One problem facing the acceptance of formal verification into circuit design methodology is that the structural circuit descriptions used by the designers are not appropriate for verification work and those required for verification lack some of the features needed for design. We offer a solution to this dilemma: an automatic translation from the designers' HDL models into definitions for the higher-ordered logic (HOL) verification system. The translated definitions become the low level basis of circuit verification which in turn increases the designer's confidence in the correctness of higher level behavioral models.

  18. Estonia's Alta buys Lauma lingerie

    Index Scriptorium Estoniae

    2004-01-01

    Eesti investeeringute firma Alta Capital ostis 76,4 protsenti pesutootja Lauma aktsiatest. Tulevikus plaanitakse suunduda Ida- ja Lääne-Euroopa turgudele. Alta Capital omab 79 protsenti Klementi aktsiatest

  19. Densidad y biomasa de macroinvertebrados acuáticos derivantes en una quebrada tropical de montaña (bogotá, colombia)

    OpenAIRE

    2013-01-01

    Se estimó la variación en la densidad de deriva de macroinvertebrados acuáticos y suaporte de materia orgánica en términos de biomasa de diferentes estados inmadurose imagos, en un tramo de una quebrada tropical de montaña ubicada en los cerrosorientales de Bogotá – Colombia y durante eventos de altas y bajas precipitaciones.Se colectó un total de 96 taxones de los cuales el más abundante fue Simulium con194 individuos (abundancia total). La densidad de deriva al igual que el aporte debiomasa...

  20. Operador de densidad. Operadores producto (2009)

    OpenAIRE

    Paniagua, Juan Carlos

    2009-01-01

    Breve introducción al formalismo del operador de densidad y su aplicación a la resonancia magnética nuclear. Se incluye el método de los operadores producto para analizar la evolución de sistemas de espines.

  1. Operador de densidad. Operadores producto (2006)

    OpenAIRE

    Paniagua, Juan Carlos

    2008-01-01

    Breve introducción al formalismo del operador de densidad y su aplicación a la resonancia magnética nuclear. Se incluye el método de los operadores producto para analizar la evolución de sistemas de espines.

  2. Operador de densidad. Operadores producto (2012)

    OpenAIRE

    Paniagua, Juan Carlos

    2012-01-01

    Breve introducción al formalismo del operador de densidad y su aplicación a la resonancia magnética nuclear. Incluye el método de los operadores producto para analizar la evolución de sistemas de espines.

  3. The Triglyceride-to-HDL Cholesterol Ratio

    OpenAIRE

    Giannini, Cosimo; Santoro, Nicola; Caprio, Sonia; Kim, Grace; Lartaud, Derek; Shaw, Melissa; Pierpont, Bridget; Weiss, Ram

    2011-01-01

    OBJECTIVE We evaluated whether the triglyceride-to-HDL cholesterol (TG/HDL-C) ratio is associated with insulin resistance (IR) in a large multiethnic cohort of obese youths. RESEARCH DESIGN AND METHODS Obese youths (1,452) had an oral glucose tolerance test and a fasting lipid profile. Insulin sensitivity was estimated using the whole body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA)-IR and evaluated, in a subgroup of 146 obese youths, by the hyperinsulinemic-eugl...

  4. Dysfunctional HDL and atherosclerotic cardiovascular disease.

    Science.gov (United States)

    Rosenson, Robert S; Brewer, H Bryan; Ansell, Benjamin J; Barter, Philip; Chapman, M John; Heinecke, Jay W; Kontush, Anatol; Tall, Alan R; Webb, Nancy R

    2016-01-01

    High-density lipoproteins (HDLs) protect against atherosclerosis by removing excess cholesterol from macrophages through the ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1) pathways involved in reverse cholesterol transport. Factors that impair the availability of functional apolipoproteins or the activities of ABCA1 and ABCG1 could, therefore, strongly influence atherogenesis. HDL also inhibits lipid oxidation, restores endothelial function, exerts anti-inflammatory and antiapoptotic actions, and exerts anti-inflammatory actions in animal models. Such properties could contribute considerably to the capacity of HDL to inhibit atherosclerosis. Systemic and vascular inflammation has been proposed to convert HDL to a dysfunctional form that has impaired antiatherogenic effects. A loss of anti-inflammatory and antioxidative proteins, perhaps in combination with a gain of proinflammatory proteins, might be another important component in rendering HDL dysfunctional. The proinflammatory enzyme myeloperoxidase induces both oxidative modification and nitrosylation of specific residues on plasma and arterial apolipoprotein A-I to render HDL dysfunctional, which results in impaired ABCA1 macrophage transport, the activation of inflammatory pathways, and an increased risk of coronary artery disease. Understanding the features of dysfunctional HDL or apolipoprotein A-I in clinical practice might lead to new diagnostic and therapeutic approaches to atherosclerosis. PMID:26323267

  5. Materiales de cambio de fase basados en mezclas de polietileno de alta densidad y cera

    OpenAIRE

    Utande Clemente, Rocío

    2013-01-01

    El objetivo de este proyecto consiste en la elaboración y caracterización de mezclas de polímero-cera, constituidas por una serie de diferentes porcentajes de los compuestos principales, HDPE y cera parafina, para su potencial empleo como materiales de cambio de fase. A raíz de las necesidades planteadas por parte del actual mercado y los retos multidisciplinares a los que nos enfrentamos en el futuro de campos como, por ejemplo, el de la edificación, tanto Universidades, co...

  6. Análisis del ciclo de vida del reciclado del polietileno de alta densidad

    OpenAIRE

    Garraín Cordero, Daniel; Vidal Nadal, María Rosario; Franco García, Vicente; Martínez Sebastiá, Pilar

    2008-01-01

    Thermoplastics make up roughly 80% of the plastics produced today. There are hundreds of types of them and new variations are being developed. But not all thermoplastics are recyclable in the same proportion. The most commonly recycled thermoplastics are polyethylene (PE), polypropylene (PP), polystyrene (PS) and polyvinyl chloride (PVC). In this study, real data from the industry is used in the analysis of the environmental impact of plastics recycling by means of the application of the ...

  7. Uropatia Obstrutiva Alta

    OpenAIRE

    Campos Pinheiro, L; Matos Ferreira, A

    1999-01-01

    As lesões obstrutivas do aparelho urinário são muito frequentes. Apresenta-se uma revisão da etiologia e fisiopatologia da uropatia obstrutiva alta. Descreve-se pormenorizadamente a sua clínica e diagnóstico realçando-se os exames complementares mais adequados. Por fim apresentam-se as orientações terapêuticas e o prognóstico das diversas situações englobadas neste capítulo.

  8. de alta frecuencia

    Directory of Open Access Journals (Sweden)

    Juan Carlos Gáquez Abab

    2007-01-01

    Full Text Available Los mercados de consumo de alta frecuencia presentan rasgos particulares en cuanto a la diversidad de estrategias de precio, constantes promociones en precio, publicidad masiva o estrategias de marca que hacen que la identificación de segmentos sea especialmente interesante para la empresa. En el presente trabajo se lleva a cabo un análisis de segmentación sobre datos de panel que pretende identificar cuántos segmentos existen y describir cuál es su comportamiento en relación a variables como el precio o las promociones de ventas.

  9. Hinting en pantallas de alta resolución

    OpenAIRE

    Rodriguez, D

    2012-01-01

    Las pantallas de alta resolución no son algo nuevo —hay prototipos documentados ya en los años ochenta— pero al parecer ha llegado el momento de implantar esta tecnología: en junio de 2010 Steve Jobs presentó el iPhone 4 con la pantalla Retina como principal novedad: una superfície de 3,5 pulgadas con una densidad de 336 píxeles por pulgada. El ojo humano es incapaz de distinguir los píxeles en una imagen de esa resolución, por lo que el equipo directivo de Apple decidió bautizarla como Retin...

  10. High pre-beta1 HDL concentrations and low lecithin: cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol

    DEFF Research Database (Denmark)

    Sethi, Amar A; Sampson, Maureen; Warnick, Russell;

    2010-01-01

    We hypothesized that patients with high HDL-cholesterol (HDL-C) and ischemic heart disease (IHD) may have dysfunctional HDL or unrecognized nonconventional risk factors.......We hypothesized that patients with high HDL-cholesterol (HDL-C) and ischemic heart disease (IHD) may have dysfunctional HDL or unrecognized nonconventional risk factors....

  11. Friend Turns Foe: Transformation of Anti-Inflammatory HDL to Proinflammatory HDL during Acute-Phase Response

    Directory of Open Access Journals (Sweden)

    Hima Bindu G

    2011-01-01

    Full Text Available High-density lipoprotein (HDL is a major carrier of cholesterol in the blood. Unlike other lipoproteins, physiological functions of HDL influence the cardiovascular system in favorable ways except when HDL is modified pathologically. The cardioprotective mechanism of HDL is mainly based on reverse cholesterol transport, but there has been an emerging interest in the anti-inflammatory and antioxidant roles of HDL. These latter activities of HDL are compromised in many pathological states associated with inflammation. Further, abnormal HDL can become proinflammatory contributing to oxidative damage. In this paper, we discuss the functional heterogeneity of HDL, how alterations in these particles in inflammatory states result in loss of both antioxidant activity and reverse cholesterol transport in relation to atherosclerosis, and the need for assays to predict its functionality.

  12. HDL Cholesterol and Risk of Type 2 Diabetes

    DEFF Research Database (Denmark)

    Haase, Christiane L; Tybjærg-Hansen, Anne; Nordestgaard, Børge G;

    2015-01-01

    Observationally, low levels of HDL cholesterol are consistently associated with increased risk of type 2 diabetes. Therefore, plasma HDL cholesterol increasing has been suggested as a novel therapeutic option to reduce the risk of type 2 diabetes. Whether levels of HDL cholesterol are causally...... associated with type 2 diabetes is unknown. In a prospective study of the general population (n = 47,627), we tested whether HDL cholesterol-related genetic variants were associated with low HDL cholesterol levels and, in turn, with an increased risk of type 2 diabetes. HDL cholesterol-decreasing gene scores...... and allele numbers associated with up to -13 and -20% reductions in HDL cholesterol levels. The corresponding theoretically predicted hazard ratios for type 2 diabetes were 1.44 (95% CI 1.38-1.52) and 1.77 (1.61-1.95), whereas the genetic estimates were nonsignificant. Genetic risk ratios for type 2...

  13. DENSIDAD POBLACIONAL Y ESTRUCTURA DE GRUPO DE Ateles hybridus brunneus (PRIMATES: ATELIDAE) EN UN FRAGMENTO DE BOSQUE AISLADO EN EL SURORIENTE DE ANTIOQUIA, COLOMBIA

    OpenAIRE

    Néstor J. Roncancio; Lina M. García; Amilvia Acosta

    2010-01-01

    Se encontró un grupo de Ateles hybridus brunneus en un fragmento de bosque aislado de 21 ha, con una densidad de 39 individuos/km2 (IC95% = 21.3-72.9). Esta área es la más pequeña donde se ha estimado alta densidad para Ateles. El grupo de A. h. brunneus estuvo compuesto por nueve individuos, grupo más pequeño que el registrado en otras investigaciones. Ateles tiene un sistema social fisión-fusión, donde los grupos se dividen en subgrupos. El tamaño promedio de subgrupo fue de cuatro individu...

  14. Transporte de juvenis de curimbatá Prochilodus lineatus em diferentes densidades =Transportation of curimbata Prochilodus lineatus juveniles in different densities

    OpenAIRE

    André Fernando Nascimento Gonçalves; Leonardo Susumu Takahashi; Elisabeth Criscuolo Urbinati; Jaqueline Dalbello Biller; João Batista Kochenborger Fernandes

    2010-01-01

    Neste estudo foi avaliado o efeito do transporte de curimbatá Prochilodus lineatus, em três densidades (100, 150 e 250 g L-1), sobre a sobrevivência e variáveis metabólicas, iônicas e hematológicas (série vermelha). Juvenis de curimbatá foram transportados em sacos plásticos durante 6h e amostrados antes da embalagem, imediatamente após a chegada, 24 e 96h após o transporte. Os peixes transportados na densidade mais alta apresentaram maior mortalidade durante o período de recuperação. As vari...

  15. Ajuste do modelo de Reineke para estimativa da linha de máxima densidade na Floresta Estacional Decidual no Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Evandro Alcir Meyer

    2013-08-01

    Full Text Available O objetivo deste trabalho foi estudar a relação entre a densidade de árvores por hectare e o diâmetro médio de uma Floresta Estacional Decidual, bem como ajustar o modelo Reineke para descrever esse comportamento, comparando o desempenho de diferentes métodos. A área de estudo localiza-se no Município de Silveira Martins, na região central do Rio Grande do Sul, e encontra-se em estágio inicial de sucessão, após o uso agrícola. As informações referentes ao número de árvores por hectare e ao diâmetro médio foram obtidas por meio do método de densidade pontual proposto por Spurr. As amostras foram tomadas nos estágios iniciais de uma floresta secundária, escolhendo-se áreas onde predominava o camboatá-vermelho (Cupania vernalis. Como as florestas naturais apresentam espaçamento irregular, a densidade é bastante variável. Assim, para selecionar apenas parcelas em alta densidade, foram escolhidas áreas onde se verificava a ocorrência de indivíduos mortos. Foram testados diferentes métodos para estimar o limite superior da linha de autodesbaste: a análise de regressão (para todos os dados e densidade relativa maior que 60%, corrigindo o intercepto para que os resíduos fossem negativos; o ajuste manual; o de densidade relativa (DR>90%; e a análise de fronteira estocástica. O método que melhor estimou a máxima densidade foi a análise de regressão com dados de no mínimo 60% da densidade máxima, obtendo-se um coeficiente angular de -1,563 para o modelo de Reineke. Não houve diferença significativa entre as potências fornecidas pelos diferentes métodos.

  16. HDL Revisited: New Opportunities for Managing Dyslipoproteinaemia and Cardiovascular Disease

    OpenAIRE

    Watts, Gerald F.; Burnett, John R

    2004-01-01

    Low concentrations of high-density lipoprotein (HDL) cholesterol constitute a risk factor for coronary heart disease (CHD). There is increasing evidence that increasing HDL-cholesterol levels reduces cardiovascular risk. The phenotype of low HDL cholesterol with or without elevated triglycerides is common and it is characteristic of patients with central obesity, insulin resistance, hypertension and type 2 diabetes mellitus; conditions associated with increased cardiovascular risk and are par...

  17. Dysfunctional HDL as a diagnostic and therapeutic target

    OpenAIRE

    Smith, Jonathan D.

    2009-01-01

    The atheroprotective effects of HDL are mediated by several mechanisms including its role in reverse cholesterol transport and via its anti-inflammatory properties. However, not all HDL is functionally similar. HDL and apolipoprotein A-I may become dysfunctional or even pro-inflammatory, and thus promote atherosclerosis. ApoAI post-translational modification can have a large impact on its function. Myeloperoxidase modification of apoAI impairs it function as a cholesterol acceptor, and the mo...

  18. ApoE-containing HDL and the development of atherosclerosis

    Directory of Open Access Journals (Sweden)

    Zbigniew Zdrojewski

    2015-06-01

    Full Text Available The current state of knowledge about the role of high density lipoproteins (HDL indicates that their anti-atherogenic function is mainly related to the effectiveness of their actions (mostly to the participation in reverse cholesterol transport from tissues to liver rather than the concentration of HDL itself. HDLs are highly heterogeneous in their structure, lipid and protein composition and metabolic pathways and individual HDL subpopulations differ in their biological activity and effectiveness of anti-atherogenic actions. Apolipoproteins play a key role in HDL metabolism, therefore their presence in lipoproteins is one of the main criterion for HDL classification. According to this criterion HDLs containing apolipoprotein E, called HDL-apoE, are distinguished. Although the anti-atherogenic role of apo E has been demonstrated in many scientific reports, understanding of the mechanisms of formation, transformation and the role of HDL-apoE is still the aim of intense research. The results of epidemiological studies are inconclusive; some of them have demonstrated that high HDL- -apoE concentration has been associated with lower risk of developing coronary heart disease (CHD, while other studies have shown that high levels of HDL-apoE has been an independent risk factor for cardiovascular events and positively correlated with other risk factors for CHD.

  19. [HDL cholesterol as a sensitive diagnostic parameter in malaria].

    Science.gov (United States)

    Kittl, E M; Diridl, G; Lenhart, V; Neuwald, C; Tomasits, J; Pichler, H; Bauer, K

    1992-01-01

    In patients with malaria the lipid parameters triglycerides, cholesterol, and HDL-cholesterol were determined routinely. At the time of admission hypertriglyceridemia, hypocholesterolemia, and an extreme decrease in HDL-cholesterol were found. This dyslipoproteinemia was present in cases of falciparum malaria, as well as in cases of benign tertian malaria. The extent of HDL-cholesterol decrease showed no correlation to the severity of the clinical course of disease. HDL-cholesterol has proven to be an independent diagnostic laboratory finding in cases of suspected malarial infection. This parameter displays high diagnostic sensitivity, but no specificity for malaria. PMID:1546481

  20. Endothelial lipase is a major determinant of HDL level

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, Tatsuro; Choi, Sungshin; Kundu, Ramendra K.; Hirata, Ken-Ichi; Rubin, Edward M.; Cooper, Allen D.; Quertermous, Thomas

    2003-01-30

    For the past three decades, epidemiologic studies have consistently demonstrated an inverse relationship between plasma HDL cholesterol (HDL-C) concentrations and coronary heart disease (CHD). Population-based studies have provided compelling evidence that low HDL-C levels are a risk factor for CHD, and several clinical interventions that increased plasma levels of HDL-C were associated with a reduction in CHD risk. These findings have stimulated extensive investigation into the determinants of plasma HDL-C levels. Turnover studies using radiolabeled apolipoprotein A-I, the major protein component of HDL, suggest that plasma HDL-C concentrations are highly correlated with the rate of clearance of apolipoprotein AI. However, the metabolic mechanisms by which HDL are catabolized have not been fully defined. Previous studies in humans with genetic deficiency of cholesteryl ester transfer protein, and in mice lacking the scavenger receptor BI (SR-BI), have demonstrated that these proteins participate in the removal of cholesterol from HDL, while observations in individuals with mutations in hepatic lipase indicate that this enzyme hydrolyzes HDL triglycerides. In this issue of the JCI, reports from laboratories of Tom Quertermous and Dan Rader now indicate that endothelial lipase (LIPG), a newly identified member of the lipase family, catalyzes the hydrolysis of HDL phospholipids and facilitates the clearance of HDL from the circulation. Endothelial lipase was initially cloned by both of these laboratories using entirely different strategies. Quertermous and his colleagues identified endothelial lipase as a transcript that was upregulated in cultured human umbilical vein endothelial cells undergoing tube formation, whereas the Rader group cloned endothelial lipase as a transcript that was upregulated in the human macrophage-like cell line THP-1 exposed to oxidized LDL. Database searches revealed that endothelial lipase shows strong sequence similarity to lipoprotein

  1. Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo

    OpenAIRE

    Sacks, Frank M.; Rudel, Lawrence L.; Conner, Adam; Akeefe, Hassibullah; Kostner, Gerhard; Baki, Talal; Rothblat, George; de la Llera-Moya, Margarita; Asztalos, Bela; Perlman, Timothy; Zheng, Chunyu; Alaupovic, Petar; Maltais, Jo-Ann B.; Brewer, H. Bryan

    2009-01-01

    Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that transfers its cholesterol to the liver facilitating excretion. Most HDL in plasma is cholesterol-rich. We demonstrate that treating plasma with a novel selective delipidation procedure converts large to small HDL [HDL-selectively delipidated (HDL-sdl)]. HDL-sdl contains seve...

  2. La densidad urbana como variable de análisis de la ciudad: El caso de Cuenca, Ecuador

    Directory of Open Access Journals (Sweden)

    M. Augusta Hermida

    2015-09-01

    Full Text Available El debate teórico sobre la ciudad dispersa versus la ciudad compacta, en el mundo y particularmente en América Latina, pone en la palestra los aspectos clave necesarios para proponer un nuevo modelo de ciudad, donde la calidad de vida de las presentes y futuras generaciones sea el punto focal de reflexión. A través del estudio del estado del arte sobre el tema se concluye que el regreso a la ciudad compacta es la alternativa para un posible desarrollo sustentable en las ciudades intermedias de América Latina. En el caso de Cuenca, se concentra el estudio en las densidades de la ciudad desde los años cincuenta hasta nuestros días. Sorprende comprobar que Cuenca fue una ciudad compacta con alta calidad de vida pero que, paulatinamente, se está expandiendo innecesariamente, con todos los problemas que ello implica.

  3. Servidores web de altas prestaciones

    OpenAIRE

    Castillo Valdivieso, Pedro; Bernier Villamor, Jos?? Luis; Mora Garc??a, Antonio Miguel; Garc??a-S??nchez, Pablo; Garc??a Arenas, Mar??a Isabel

    2013-01-01

    Para crear un sitio web exitoso debemos ser cuidadosos con muchos detalles, ya que la arquitectura, la selecci??n del hardware, o la implementaci??n de las aplicaciones afectar??n al rendimiento del sistema completo. Es m??s, un sitio que no est?? preparado para dar servicio a un n??mero creciente de clientes o usuarios, a la larga puede llevar al fracaso a la empresa. En este trabajo, se presenta una visi??n general de la nueva asignatura Servidores Web de Altas Prestaciones, del nuevo plan...

  4. Basics of Verilog HDL and design of digital logic circuit

    International Nuclear Information System (INIS)

    This book explains of the basic of Verilog HDL and design of digital logic circuit with ALTERA Quartus II and MAX + PLUS II. It comprised four charters, which include four chapters, introduction of ASIC, ALTERA design software and introduction, basic of Verilog HDL and making of download cable like parallel download, MAX 7000s device and FPGA circuit constitution and test, design of digital logic circuit with basic of Verilog HDL, design of combination logic circuit and order logic circuit, application circuit design such as 7 segment LED display design, LCD display device design and digital clocks.

  5. Whey protein improves HDL/non-HDL ratio and body weight gain in rats subjected to the resistance exercise

    Directory of Open Access Journals (Sweden)

    Kely Raspante Teixeira

    2012-12-01

    Full Text Available The aim of this study was to evaluate the effects of resistance exercise, such as weight-lifting (WL on the biochemical parameters of lipid metabolism and cardiovascular disease risk in the rats fed casein (control or whey protein (WP diets. Thirty-two male Fisher rats were randomly assigned to sedentary or exercise-trained groups and were fed control or WP diets. The WL program consisted of inducing the animals to perform the sets of jumps with weights attached to the chest. After seven weeks, arteriovenous blood samples were collected for analysis. The WL or WP ingestion were able to improve the lipid profile, reducing the TC and non-HDL cholesterol concentrations, but only WP treatment significantly increased the serum HDL concentrations, thereby also affecting the TC/HDL and HDL/non-HDL ratios. However, WL plus WP was more effective in improving the HDL/non-HDL ratio than the exercise or WP ingestion alone and the body weight gain than exercise without WP ingestion.

  6. Appraisal of a HDPE internal liner; Avaliacao de revestimento interno de duto em polietileno de alta densidade

    Energy Technology Data Exchange (ETDEWEB)

    Meniconi, Luiz C.M.; Perrut, Valber A.; Castellares, Lizabeth G. [PETROBRAS, Rio de Janeiro, RJ (Brazil). Centro de Pesquisas (CENPES); Medeiros, Raimundo C. [PETROBRAS, SP (Brazil). Setor de Qualificacao e Certificacao (SEQUI)

    2005-07-01

    The mechanical properties of a high density polyethylene were evaluated by tensile and tearing tests, after ageing for up to 28 days of immersion in crude oil at 55 deg C. After that, the performance of the polymer as a liner of a metallic pipeline was appraised. A situation was simulated in which an infinitely long defect was supposed to exist along the inner bottom of the pipeline, due to pitting corrosion. Under internal pressure, the liner is pushed and bent against the empty space behind it, causing a tensile stress on its outer surface. The abrasion between the liner and the pipeline during liner installation can create scratches in the liner. The scratches would behave as notches for the initiation of a propagating defect, under the tensile load mentioned above. Finite Element Modeling was used to define the limit values of internal pressure, liner thickness and defect size that would cause defect propagation. The simulation was performed for typical values of pipeline diameter, defect size and liner thickness. (author)

  7. HDL dysfunction in diabetes: causes and possible treatments

    OpenAIRE

    Farbstein, Dan; Levy, Andrew P.

    2012-01-01

    HDL is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. These functions include cholesterol efflux and reverse cholesterol transport, antioxidative and anti-inflammatory activities. However, HDL has been shown to undergo a loss of function in several pathophysiological states, as in the acute phase response, obesity and chronic inflammatory diseases. Some of these diseases were also shown to be associated with increased risk for cardio...

  8. Origins and determinants of HDL populations and their subpopulations

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, A.V.; Gong, E.L.

    1990-06-01

    This paper describes the origins and determinants of High Density Lipoproteins (HDL) populations and their subpopulations. Our survey of compositional properties of small HDL particles indicates considerable variation in core lipid content reflecting in large part the origins of such particles. Whether small HDL particles of different core content and apolipoprotein composition differ in their metabolic properties and function in reverse cholesterol transport remains to be established. Our studies demonstrate that lipolysis-derived products can facilitate formation in vitro of small Apolipoprotein (AI) particles with properties approximating those of plasma pre-{beta} HDL. Of particular interest is our observation that small AI particles are an exclusive reassembly product in mixtures containing POPE and FFA. This observation may be relevant to the physiologic origins of PE in lipoprotein structure and its role in metabolism and secretion of nascent HDL. Lastly our observations on the reactivity of small AI particles, containing FFA, with LCAT and LDL suggest further linkages between triglyceride and HDL metabolism. 19 refs., 4 figs., 5 tabs.

  9. LCAT, HDL Cholesterol and Ischemic Cardiovascular Disease: A Mendelian Randomization Study of HDL Cholesterol in 54,500 Individuals

    DEFF Research Database (Denmark)

    Haase, Christiane L; Tybjærg-Hansen, Anne; Ali Qayyum, Abbas;

    2012-01-01

    Background:Epidemiologically, high-density lipoprotein (HDL) cholesterol levels associate inversely with risk of ischemic cardiovascular disease. Whether this is a causal relation is unclear.Methods:We studied 10,281 participants in the Copenhagen City Heart Study (CCHS) and 50,523 participants in...... the Copenhagen General Population Study (CGPS), of which 991 and 1,693 participants, respectively, had developed myocardial infarction (MI) by August 2010. Participants in the CCHS were genotyped for all six variants identified by resequencing lecithin-cholesterol acyltransferase in 380 individuals....... One variant, S208T (rs4986970, allele frequency 4%), associated with HDL cholesterol levels in both the CCHS and the CGPS was used to study causality of HDL cholesterol using instrumental variable analysis.Results:Epidemiologically, in the CCHS, a 13% (0.21 mmol/liter) decrease in plasma HDL...

  10. STUDIES ON THE HDL RECEPTORS I:EVIDENCE FOR THE EXISTENCE OF HDL RECEPTORS IN BEIJING DUCK LIVER

    Institute of Scientific and Technical Information of China (English)

    武须军; 王克勤

    1994-01-01

    It hab been found that Beijing ducks (BD)have a high level of HDL(70%),high LCAT but very low CETP activity and will not develop atheroscletosis on an atherogenic diet,suggesting that cholesterol ester is mainly carried by HDL and metabolized through an HDL receptor pathway in the liver.However,evidence of this recep-tor′s existence in the liver is not yet complete.In this paper,the HDL receptor in BD liver has been studied.Our experiments showed:1)ApoE-free 125I-HDL could bind specifically to duck hepatic cell membrane with high affinity (Kd=9.6 μg/ml)and was saturable(Bmax=8.9μg/mg cell membrane protein)at room temperature.2)Competitive inhibition studies with unlabelled duck,human,rat and chick HDL and duck apo AI and its lipo-somes formed with PC or DMPC could inhibit the binding of 125I-HDL to duck hepatic cell membranes,but LDL,apo Eand their liposomes with PC or DMPC could not with the exception of duck LDL.3)The receptor could rec-ognize apo AI but not apo B or E.4)Both phosphorase A2 and pronase could inhibit the binding activity.The above results give strong evidence for the existence of a specific HLD receptor pathway in the duck liver,support-ing our hypothesis that CE in Beijing ducks is metabolized directly through the hepatic HDL receptor instead of be-ing transfered back to VLDL and LDL,then through the LDL receptor pathway.This unique way of metabolizing CE may be behind the Beijing duck′s antiatherogenicity.

  11. TransAlta: More than a utility

    International Nuclear Information System (INIS)

    TransAlta Utilities Corporation is Canada's largest privately owned utility and is also a major coal mining company. In 1989, TransAlta produced 20.9% of all coal mined in Canada. A brief history of TransAlta is presented along with TransAlta's present coal operations and plans for the next three years. An overview is presented of how TransAlta Fuel Supply is organized to utilize contracted mining operation, engineering and environmental services and in-house capabilities. Recent strategic initiatives to improve organizational efficiency and the mining operations are discussed. These range from developing a common departmental vision to modifying major mining equipment. TransAlta's proactive role in clean coal combustion such as low NOx-SOx burner, integrated combined cycle gasification, and other energy research projects is reviewed. A summary is provided of recent participation of TransAlta in environmental management initiatives. Recent successes of TransAlta's unregulated subsidiary in the development of cogeneration facilities and the future of this area of business are discussed. 8 refs., 4 figs

  12. Alta peab tasuma Kalevile mais / Kersti Saar

    Index Scriptorium Estoniae

    Saar, Kersti

    2008-01-01

    Indrek Rahumaa juhitav Alta Capital peab tasuma Oliver Kruudale Kalevi tütarfirmade eest 660 miljonit krooni hiljemalt 30. maiks. Vt. samas: Investorid teavad tehingu hinda ja lõplikku tähtaega. Diagramm: Kalevi turuväärtus jääb Alta müügihinnale alla

  13. Modular hardware synthesis using an HDL. [Hardware Description Language

    Science.gov (United States)

    Covington, J. A.; Shiva, S. G.

    1981-01-01

    Although hardware description languages (HDL) are becoming more and more necessary to automated design systems, their application is complicated due to the difficulty in translating the HDL description into an implementable format, nonfamiliarity of hardware designers with high-level language programming, nonuniform design methodologies and the time and costs involved in transfering HDL design software. Digital design language (DDL) suffers from all of the above problems and in addition can only by synthesized on a complete system and not on its subparts, making it unsuitable for synthesis using standard modules or prefabricated chips such as those required in LSI or VLSI circuits. The present paper presents a method by which the DDL translator can be made to generate modular equations that will allow the system to be synthesized as an interconnection of lower-level modules. The method involves the introduction of a new language construct called a Module which provides for the separate translation of all equations bounded by it.

  14. Bile Acids Reduce Endocytosis of High-Density Lipoprotein (HDL) in HepG2 Cells

    OpenAIRE

    Clemens Röhrl; Karin Eigner; Stefanie Fruhwürth; Herbert Stangl

    2014-01-01

    High-density lipoprotein (HDL) transports lipids to hepatic cells and the majority of HDL-associated cholesterol is destined for biliary excretion. Cholesterol is excreted into the bile directly or after conversion to bile acids, which are also present in the plasma as they are effectively reabsorbed through the enterohepatic cycle. Here, we provide evidence that bile acids affect HDL endocytosis. Using fluorescent and radiolabeled HDL, we show that HDL endocytosis was reduced in the presence...

  15. HDL-replacement therapy: mechanism of action, types of agents and potential clinical indications

    OpenAIRE

    Remaley, Alan T.; Amar, Marcelo; Sviridov, Dmitri

    2008-01-01

    HDL-replacement therapy is a promising new treatment strategy involving the acute administration of HDL to rapidly stabilize patients at imminent risk for developing a myocardial infarction, such as those with acute coronary syndrome. This review will first focus on the anti-atherogenic mechanisms for HDL, such as the stimulation of the reverse cholesterol transport pathway, and then discuss the other potential beneficial biological effects of HDL on atherosclerosis. The various types of HDL-...

  16. HIFSuite: Tools for HDL Code Conversion and Manipulation

    Directory of Open Access Journals (Sweden)

    Bombieri Nicola

    2010-01-01

    Full Text Available Abstract HIFSuite ia a set of tools and application programming interfaces (APIs that provide support for modeling and verification of HW/SW systems. The core of HIFSuite is the HDL Intermediate Format (HIF language upon which a set of front-end and back-end tools have been developed to allow the conversion of HDL code into HIF code and vice versa. HIFSuite allows designers to manipulate and integrate heterogeneous components implemented by using different hardware description languages (HDLs. Moreover, HIFSuite includes tools, which rely on HIF APIs, for manipulating HIF descriptions in order to support code abstraction/refinement and postrefinement verification.

  17. Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo.

    Science.gov (United States)

    Sacks, Frank M; Rudel, Lawrence L; Conner, Adam; Akeefe, Hassibullah; Kostner, Gerhard; Baki, Talal; Rothblat, George; de la Llera-Moya, Margarita; Asztalos, Bela; Perlman, Timothy; Zheng, Chunyu; Alaupovic, Petar; Maltais, Jo-Ann B; Brewer, H Bryan

    2009-05-01

    Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that transfers its cholesterol to the liver facilitating excretion. Most HDL in plasma is cholesterol-rich. We demonstrate that treating plasma with a novel selective delipidation procedure converts large to small HDL [HDL-selectively delipidated (HDL-sdl)]. HDL-sdl contains several cholesterol-depleted species resembling small alpha, prebeta-1, and other prebeta forms. Selective delipidation markedly increases efficacy of plasma to stimulate ABCA1-mediated cholesterol transfer from monocytic cells to HDL. Plasma from African Green monkeys underwent selective HDL delipidation. The delipidated plasma was reinfused into five monkeys. Prebeta-1-like HDL had a plasma residence time of 8 +/- 6 h and was converted entirely to large alpha-HDL having residence times of 13-14 h. Small alpha-HDL was converted entirely to large alpha-HDL. These findings suggest that selective HDL delipidation activates reverse cholesterol transport, in vivo and in vitro. Treatment with delipidated plasma tended to reduce diet-induced aortic atherosclerosis in monkeys measured by intravascular ultrasound. These findings link the conversion of small to large HDL, in vivo, to improvement in atherosclerosis. PMID:19144994

  18. HIV-infected patients show functionally defective high-density lipoprotein (HDL paralleled with changes in HDL-associated proteins

    Directory of Open Access Journals (Sweden)

    V Estrada

    2012-11-01

    Full Text Available Purpose of the study Epidemiological studies have consistently demonstrated an inverse association between plasma HDL concentrations and cardiovascular risk. Although this cardioprotective role has been mainly attributed to its role in promoting cellular cholesterol efflux, there is an emerging interest in the anti-inflammatory and antioxidant properties of HDL. The aim of the study is to investigate the anti-inflammatory properties of HDL isolated from HIV-infected patients. Methods Cross-sectional study of 113 HIV-infected patients and 70 non-infected control subjects without evident CVD. From each subject, HDL was isolated by ultracentrifugation and its anti-inflammatory status was tested as its ability to inhibit MCP-1-induced migration of the monocytic cell line THP-1 using transwell cell culture chamber inserts with micropore filters of 5 microns pore size. HDL-associated proteins were measured by commercial ELISAs. Results Twenty-three HIV-infected patients were ART-naïve (32±15 years, 66.7% male and ninety were currently on ART (46±11 years, 78.9 % male. Most patients on ART (91.1% had undetectable viral load (<50 copies/mL. When compared to healthy subjects, both naïve and treated HIV-infected patients had lower plasma HDL-cholesterol levels (naïve: 45±12, ART: 50±10, controls: 55±10 mg/dL, p<0.05. HDL isolated from HIV naïve patients showed a significantly reduced anti-inflammatory activity (THP-1 monocyte migration capacity was 203% times higher in HIV patients than in control subjects. The anti-inflammatory activity of HDL from ART-treated HIV-infected patients was significantly improved when compared to naïve patients, although it remained significantly lower than controls (130% THP-1 monocyte migration vs controls. HDL from HIV-infected patients had a decreased concentration of the anti-inflammatory proteins Apo A1 (controls: 2.1±0.3, naïve: 1.4±0.2, ART: 1.6±0.1 mg/ml and LCAT (controls: 0.53±0.09, naïve: 0.34±0

  19. Plasma HDL cholesterol and risk of myocardial infarction

    DEFF Research Database (Denmark)

    Voight, Benjamin F; Peloso, Gina M; Orho-Melander, Marju;

    2012-01-01

    High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes......, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal....

  20. HDL abnormalities in nephrotic syndrome and chronic kidney disease.

    Science.gov (United States)

    Vaziri, Nosratola D

    2016-01-01

    Normal HDL activity confers cardiovascular and overall protection by mediating reverse cholesterol transport and through its potent anti-inflammatory, antioxidant, and antithrombotic functions. Serum lipid profile, as well as various aspects of HDL metabolism, structure, and function can be profoundly altered in patients with nephrotic range proteinuria or chronic kidney disease (CKD). These abnormalities can, in turn, contribute to the progression of cardiovascular complications and various other comorbidities, such as foam cell formation, atherosclerosis, and/or glomerulosclerosis, in affected patients. The presence and severity of proteinuria and renal insufficiency, as well as dietary and drug regimens, pre-existing genetic disorders of lipid metabolism, and renal replacement therapies (including haemodialysis, peritoneal dialysis, and renal transplantation) determine the natural history of lipid disorders in patients with kidney disease. Despite the adverse effects associated with dysregulated reverse cholesterol transport and advances in our understanding of the underlying mechanisms, safe and effective therapeutic interventions are currently lacking. This Review provides an overview of HDL metabolism under normal conditions, and discusses the features, mechanisms, and consequences of HDL abnormalities in patients with nephrotic syndrome or advanced CKD. PMID:26568191

  1. Design time optimization for hardware watermarking protection of HDL designs.

    Science.gov (United States)

    Castillo, E; Morales, D P; García, A; Parrilla, L; Todorovich, E; Meyer-Baese, U

    2015-01-01

    HDL-level design offers important advantages for the application of watermarking to IP cores, but its complexity also requires tools automating these watermarking algorithms. A new tool for signature distribution through combinational logic is proposed in this work. IPP@HDL, a previously proposed high-level watermarking technique, has been employed for evaluating the tool. IPP@HDL relies on spreading the bits of a digital signature at the HDL design level using combinational logic included within the original system. The development of this new tool for the signature distribution has not only extended and eased the applicability of this IPP technique, but it has also improved the signature hosting process itself. Three algorithms were studied in order to develop this automated tool. The selection of a cost function determines the best hosting solutions in terms of area and performance penalties on the IP core to protect. An 1D-DWT core and MD5 and SHA1 digital signatures were used in order to illustrate the benefits of the new tool and its optimization related to the extraction logic resources. Among the proposed algorithms, the alternative based on simulated annealing reduces the additional resources while maintaining an acceptable computation time and also saving designer effort and time. PMID:25861681

  2. Riqueza e densidade de aves que nidificam em cavidades em plantações abandonadas de eucalipto

    Directory of Open Access Journals (Sweden)

    Hugo de Siqueira Pereira

    2015-05-01

    Full Text Available Monoculturas de árvores, como as de espécies de eucalipto, têm substituído florestas naturais, impactando a fauna pela perda de habitat e recursos. Diversas espécies de aves necessitam de ocos em árvores para nidificar. A falta de recursos como cavidades formadas pela degradação da árvore ou locais apropriados para serem criadas cavidades leva a diminuição na abundância das populações destas espécies. Este trabalho tem o objetivo de comparar a riqueza e a densidade de aves que nidificam em ocos em áreas de plantação de eucalipto abandonadas com áreas de vegetação nativa em duas unidades de conservação em Minas Gerais. Em cada tipo de vegetação de cada reserva foram estabelecidos 25 pontos, nas quais foi utilizado o método de contagem por remoção para o levantamento das espécies de aves. A riqueza de espécies de aves de cada área foi estimada por Jackniffe e a densidade foi estimada através do método de máxima verossimilhança; modelos candidatos que poderiam influenciar a abundância das aves foram avaliados utilizando-se o Critério de Informação Akaike (AIC. Os resultados mostraram que a riqueza de espécies foi maior nas áreas de florestas nativas e que a densidade foi significantemente mais alta nas áreas de florestas nativas, e que o tipo de vegetação e a hora do dia influenciam na abundância e detecção das aves. Esses resultados indicam que as plantações de eucaliptos influenciam negativamente a comunidade de aves que nidificam em ocos, provavelmente por causa da falta de cavidades ou de sub-bosque. Plantações de eucaliptos normalmente não substituem as florestas nativas e seu uso deve ser controlado em áreas de conservação.

  3. Development of a high density fuel based on uranium-molybdenum alloys with high compatibility in high temperatures; Desenvolvimento de um combustivel de alta densidade a base das ligas uranio-molibdenio com alta compatibilidade em altas temperaturas

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Fabio Branco Vaz de

    2008-07-01

    This work has as its objective the development of a high density and low enriched nuclear fuel based on the gamma-UMo alloys, for utilization where it is necessary satisfactory behavior in high temperatures, considering its utilization as dispersion. For its accomplishment, it was started from the analysis of the RERTR ('Reduced Enrichment for Research and Test Reactors') results and some theoretical works involving the fabrication of gamma-uranium metastable alloys. A ternary addition is proposed, supported by the properties of binary and ternary uranium alloys studied, having the objectives of the gamma stability enhancement and an ease to its powder fabrication. Alloys of uranium-molybdenum were prepared with 5 to 10% Mo addition, and 1 and 3% of ternary, over a gamma U7Mo binary base alloy. In all the steps of its preparation, the alloys were characterized with the traditional techniques, to the determination of its mechanical and structural properties. To provide a process for the alloys powder obtention, its behavior under hydrogen atmosphere were studied, in thermo analyser-thermo gravimeter equipment. Temperatures varied from the ambient up to 1000 deg C, and times from 15 minutes to 16 hours. The results validation were made in a semi-pilot scale, where 10 to 50 g of powders of some of the alloys studied were prepared, under static hydrogen atmosphere. Compatibility studies were conducted by the exposure of the alloys under oxygen and aluminum, to the verification of possible reactions by means of differential thermal analysis. The alloys were exposed to a constant heat up to 1000 deg C, and their performances were evaluated in terms of their reaction resistance. On the basis of the results, it was observed that ternary additions increases the temperatures of the reaction with aluminum and oxidation, in comparison with the gamma UMo binaries. A set of conditions to the hydration of the alloys were defined, more restrictive in terms of temperature, time and pre-treatment to stabilize the gamma structure. The addition of a bit low ternary excess and formation of an intergranular phase, the increase in stability, it was demonstrated that there is not a damage in the formation of their powders.(author)

  4. Espaçamento, densidade populacional e adubação nitrogenada na cultura do milho Row spacing, population density and nitrogen fertilization in maize

    OpenAIRE

    José Pedro Ribeiro do Amaral Filho; D. FORNASIERI FILHO; Rogerio Farinelli; José Carlos Barbosa

    2005-01-01

    A distribuição espacial de plantas por área é um recurso para aumentar a produtividade. Para materiais de alta produtividade, são necessárias mais informações quanto à resposta à adubação nitrogenada. Assim, avaliou-se na cultura do milho a influência do espaçamento, da densidade populacional e de doses de nitrogênio no teor de nitrogênio nas folhas, estimativa do teor de clorofila, número de grãos por espiga, massa de 1.000 grãos, produtividade e teor de proteína nos grãos. O trabalho foi in...

  5. Seleção de progênies S0:1 de milho em diferentes densidades de semeadura Selection of S0:1 maize progenies under different plant densities

    Directory of Open Access Journals (Sweden)

    André Gustavo Steola

    2006-01-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito da densidade de semeadura sobre o processo de seleção de progênies endogâmicas S0:1 de milho. Utilizaram-se 98 progênies S0:1 derivadas do híbrido simples GNZ 2004, avaliadas em duas densidades de semeadura (50 mil e 75 mil plantas ha-1 . Em cada densidade foram avaliadas as 98 progênies S0:1, juntamente com o híbrido GNZ 2004 e sua geração F2. O delineamento utilizado em ambas as densidades foi o látice simples 10 x 10, com duas repetições. Os experimentos foram desenvolvidos em área experimental do Departamento de Agricultura da Universidade Federal de Lavras, em Lavras (MG. As características avaliadas foram produtividade de espigas despalhadas e prolificidade. Pelos resultados obtidos constatou-se variabilidade genética entre as progênies S0:1 nas duas densidades avaliadas, havendo a possibilidade de seleção de progênies com maior potencial de produção de espigas despalhadas. A não-significância da interação entre as progênies S0:1 e as densidades de semeadura associadas às altas correlações genéticas obtidas evidenciam que a seleção poderá ser realizada em qualquer uma das duas densidades, sem comprometer o processo seletivo.The present work aimed to evaluate the effect of planting density on the selection of inbred progenies. GNZ 2004 single hybrid, its F2 generation and ninety-eight S0:1 progenies were evaluated in two plant densities, 50 thousand and 75 thousand plants ha-1in a simple 10x10 lattice design. The experiment was performed in the experimental area of the Agriculture Department of the Universidade Federal de Lavras, in Lavras, Minas Gerais State, Brazil. Yield of husked ear and prolificy were evaluated. Results showed genetic variation among the S0:1 progenies in the two densities, allowing the selection of progenies with higher potential for production of husked ear corn. Interaction of the progenies x densities was not significant that

  6. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

    DEFF Research Database (Denmark)

    Elsøe, Sara; Ahnström, Josefin; Christoffersen, Christina;

    2012-01-01

    Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lip...... lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL....

  7. Serum- and HDL3-serum amyloid A and HDL3-LCAT activity are influenced by increased CVD-burden

    OpenAIRE

    McEneny, Jane; McKavanagh, Peter; York, Edmund; Nadeem, Nida; Harbinson, Mark; Stevenson, Michael; Ball, Peter; Lusk, Lisa; Trinick, Thomas; Young, Ian S; McKay, Gareth J; Donnelly, Patrick M.

    2016-01-01

    BACKGROUND: High density lipoproteins (HDL) protect against cardiovascular disease (CVD). However, increased serum amyloid-A (SAA) related inflammation may negate this property. This study investigated if SAA was related to CVD-burden.METHODS: Subjects referred to the rapid chest pain clinic (n = 240) had atherosclerotic burden assessed by cardiac computerised tomography angiography. Subjects were classified as: no-CVD (n = 106), non-obstructive-CVD, stenosis<50% (n = 58) or moderate/signi...

  8. Regional variations in HDL metabolism in human fat cells: effect of cell size

    International Nuclear Information System (INIS)

    Abdominal obesity is related to reduced plasma high-density lipoprotein (HDL) cholesterol, and both are associated with cardiovascular disease risk. The authors have observed that plasma membranes from abdominal subcutaneous adipocytes have a greater HDL binding capacity than omental fat cell plasma membranes. The present study examined whether these binding characteristics could be due to differences in fat cell size or cholesterol concentration between the two adipose depots. Abdominal subcutaneous and deep omental fat were obtained from massively obese patients at surgery. Subcutaneous abdominal fat cells were significantly larger and their cellular cholesterol content greater than omental adipocytes. The uptake of HDL by collagenase-isolated fat cells was studied by incubating the cells for 2 h at 370C with 10 μg/ml 125I-HDL2 or 125I-HDL3. In both depots, the cellular uptake of 125I-HDL2 and 125I-HDL3 was specifically inhibited by addition of 25-fold excess unlabeled HDL and a close correlation was observed between the cellular uptake of 125I-HDL2 and 125I-HDL3. In obese patients, the uptake of 125I-HDL was higher in subcutaneous cells than in omental cells. The cellular 125I-HDL uptake was significantly correlated with adipocyte size and fat cell cholesterol content but not with adipocyte cholesterol concentration. These results suggest that the higher HDL uptake observed in subcutaneous cells compared with omental cells in obesity is the result of differences in adipocyte size rather than differences in the cholesterol concentration (cholesterol-to-triglyceride ratio). The increased interaction of HDL with hypertrophied abdominal adipocytes may play an important role in determining the lipid composition of HDL in obesity

  9. Regional variations in HDL metabolism in human fat cells: effect of cell size

    Energy Technology Data Exchange (ETDEWEB)

    Despres, J.; Fong, B.S.; Julien, P.; Jimenez, J.; Angel, A.

    1987-05-01

    Abdominal obesity is related to reduced plasma high-density lipoprotein (HDL) cholesterol, and both are associated with cardiovascular disease risk. The authors have observed that plasma membranes from abdominal subcutaneous adipocytes have a greater HDL binding capacity than omental fat cell plasma membranes. The present study examined whether these binding characteristics could be due to differences in fat cell size or cholesterol concentration between the two adipose depots. Abdominal subcutaneous and deep omental fat were obtained from massively obese patients at surgery. Subcutaneous abdominal fat cells were significantly larger and their cellular cholesterol content greater than omental adipocytes. The uptake of HDL by collagenase-isolated fat cells was studied by incubating the cells for 2 h at 37/sup 0/C with 10 ..mu..g/ml /sup 125/I-HDL/sub 2/ or /sup 125/I-HDL/sub 3/. In both depots, the cellular uptake of /sup 125/I-HDL/sub 2/ and /sup 125/I-HDL/sub 3/ was specifically inhibited by addition of 25-fold excess unlabeled HDL and a close correlation was observed between the cellular uptake of /sup 125/I-HDL/sub 2/ and /sup 125/I-HDL/sub 3/. In obese patients, the uptake of /sup 125/I-HDL was higher in subcutaneous cells than in omental cells. The cellular /sup 125/I-HDL uptake was significantly correlated with adipocyte size and fat cell cholesterol content but not with adipocyte cholesterol concentration. These results suggest that the higher HDL uptake observed in subcutaneous cells compared with omental cells in obesity is the result of differences in adipocyte size rather than differences in the cholesterol concentration (cholesterol-to-triglyceride ratio). The increased interaction of HDL with hypertrophied abdominal adipocytes may play an important role in determining the lipid composition of HDL in obesity.

  10. Alta Capital investeerib miljardeid kroone / Raigo Neudorf

    Index Scriptorium Estoniae

    Neudorf, Raigo

    2006-01-01

    Investeerimisfirma Alta Capital nõukogu esimees Indrek Rahumaa annab ülevaate sellest, kuidas ettevõte on lühikese ajaga suutnud omandada osaluse mitmetes ettevõtetes ning suunanud neisse investeeringuid 150 miljoni euro väärtuses. Vt. samas: Osalused; Omanikud

  11. Bile acids reduce endocytosis of high-density lipoprotein (HDL in HepG2 cells.

    Directory of Open Access Journals (Sweden)

    Clemens Röhrl

    Full Text Available High-density lipoprotein (HDL transports lipids to hepatic cells and the majority of HDL-associated cholesterol is destined for biliary excretion. Cholesterol is excreted into the bile directly or after conversion to bile acids, which are also present in the plasma as they are effectively reabsorbed through the enterohepatic cycle. Here, we provide evidence that bile acids affect HDL endocytosis. Using fluorescent and radiolabeled HDL, we show that HDL endocytosis was reduced in the presence of high concentrations of taurocholate, a natural non-cell-permeable bile acid, in human hepatic HepG2 and HuH7 cells. In contrast, selective cholesteryl-ester (CE uptake was increased. Taurocholate exerted these effects extracellularly and independently of HDL modification, cell membrane perturbation or blocking of endocytic trafficking. Instead, this reduction of endocytosis and increase in selective uptake was dependent on SR-BI. In addition, cell-permeable bile acids reduced HDL endocytosis by farnesoid X receptor (FXR activation: chenodeoxycholate and the non-steroidal FXR agonist GW4064 reduced HDL endocytosis, whereas selective CE uptake was unaltered. Reduced HDL endocytosis by FXR activation was independent of SR-BI and was likely mediated by impaired expression of the scavenger receptor cluster of differentiation 36 (CD36. Taken together we have shown that bile acids reduce HDL endocytosis by transcriptional and non-transcriptional mechanisms. Further, we suggest that HDL endocytosis and selective lipid uptake are not necessarily tightly linked to each other.

  12. y alta de la subcuenca Cohatán, Chiapas

    Directory of Open Access Journals (Sweden)

    M. Grajales

    2008-01-01

    Full Text Available El estudio consistió en un diagnóstico biofísico (fisiográfico, hidrográfico, uso actual del suelo, cobertura vegetal y socioeconómico (infraestructura social y productiva con actividades en la subcuenca Cohatán, localizado en las estribaciones de la Sierra del Soconusco Chiapas, para saber la situación que guarda y generar acciones de rehabilitación, a mediano y largo plazo. Esta subcuenca se extiende desde 350 a los 4,080 msnm, con 42 comunidades, que abarcan los municipios de Tapachula, Motozintla y Cacahotán, Chiapas; tiene una densidad de 1.2 hab/ha, con suelo de origen volcánico formado del Cenozoico terciario de unidad acrisol húmico. El 80% de la superficie presenta clima tropical húmedo y subhúmedo, con relieve de ladera fuerte hasta de 60%, con una erosión hídrica severa de 250 t/ ha/año en 42% de la superficie; tiene 25% de selva, medias altas y perennifolias. La principal actividad económica es la explotación del cultivo de café, desde el área marginal 350 hasta 2,660 msnm. A lo largo del río Cohatán el tipo de desarrollo se sustenta en el uso intensivo de los recursos naturales, originan —a su vez— fuerte deterioro neceambiental, al cambio de vegetación de la selva original por introducción de especies de sombra del café con chalum (Inga spp; en este ecosistema se observa un deficiente uso de tecnología de producción que se refleja en el bajo rendimiento del café, de 8 quintales/ha. El nivel socioeconómico de desarrollo es bajo, con nivel de educación, salud, vivienda y servicios deficientes, así como falta de apoyo social, con carente gestión ambiental

  13. HDL code analysis for ASICs in mobile systems

    OpenAIRE

    Wickberg, Fredrik

    2007-01-01

    The complex work of designing new ASICs today and the increasing costs of time to market (TTM) delays are putting high responsibility on the research and development teams to make fault free designs. The main purpose of implementing a static rule checking tool in the design flow today is to find errors and bugs in the hardware definition language (HDL) code as fast and soon as possible. The sooner you find a bug in the design, the shorter the turnaround time becomes, and thereby both time and...

  14. HDL-C Response Variability to Niacin ER in US Adults

    Science.gov (United States)

    Christian, Jennifer B.; Olson, Eric J.; Allen, Jeffery K.; Lowe, Kimberly A.

    2013-01-01

    Background. Niacin is the most effective treatment currently available for raising HDL-C levels. Objective. To evaluate if gender and baseline lipid levels have an effect on the HDL-C response of niacin ER and to identify factors that predict response to niacin ER at the 500 mg dose. Material and Methods. The change in HDL-C effect between baseline and follow-up levels was quantified in absolute change as well as dichotomized into high versus low response (high response was defined as an HDL-C effect of >15% increase and low response was HDL-C <5%) in a sample of 834 individuals. Results. Both males and females with low HDL-C levels at baseline exhibited a response to treatment in the multivariate model (males, HDL-C <40 mg/dL: OR = 5.18, 95% CI: 2.36–11.39; females, HDL-C <50 mg/dL: OR = 5.40, 95% CI: 1.84–15.79). There was also a significant difference in the mean HDL-C effect between baseline and follow-up HDL-C levels in the 500 mg niacin ER dose group for both males (mean HDL-C effect = 0.08, P < 0.001) and females (mean HDL-C effect = 0.10, P = 0.019). Conclusion. Baseline HDL-C levels are the biggest predictor of response to niacin ER treatment for both males and females among the factors evaluated. PMID:23533734

  15. Equipament a la part alta de Tarragona

    OpenAIRE

    Padrós Tortares, Laura

    2010-01-01

    L'exercici proposa una solució de l'accessiblitat a nivell urbà del casc antic, al temps que l'edifici respon un equipament destinat a la població majoritaria resident de la part alta de tarragona. El projecte vol obrir i al mateix temps donar funcionalitat a una part de les runes del circ romà que se situen als baixos de l'edifici, incloent-los en l'equipament.

  16. Diffusione molecolare neLl' alta atmosfera

    Directory of Open Access Journals (Sweden)

    C. ARDUINI

    1963-06-01

    Full Text Available Le perturbazioni indotte nell'alta atmosfera dall'emissione,
    a mezzo di razzi sonda, di nubi di vapori estranei sono un utile
    mezzo per lo studio simultaneo di alcune caratteristiche fisiche e dinamiche
    degli alti strati.
    La presente relazione illustra in breve i principi di alcune tecniche
    per la misura del coefficiente di diffusione binaria tra l'aria e il vapore
    della nube artificiale.

  17. TransAlta 2003 annual report

    International Nuclear Information System (INIS)

    This annual report presents financial information from TransAlta Corp., along with a review of its operations throughout 2003 and a summary of the how the electric utility has performed in terms of power generation, independent power producers, transmission and energy marketing. TransAlta is one of the largest non-regulated power generation and wholesale marketing companies in Canada. It's assets include coal-fired, gas-fired, hydro and renewable generation facilities in Canada, the United States, Mexico and Australia. Reported earnings in 2003 were $1.26 per share compared to $1.17 in 2002. The strong first quarter was followed by harsh market conditions, low water levels which affected hydro production, and pricing restrictions in Ontario that reduced contribution from the Sarnia plant. This report outlines the utility's progress in increasing revenue and producing more power. In 2003, unplanned outages were reduced by 7 per cent and injury frequency rate was reduced by 27 per cent. The installation of 114 wind turbines in Fort Macleod, Alberta, increased TransAlta's renewable energy capacity to 3.7 per cent in 2003. The wind farm produces 75 MW of electricity, enough to power more than 32,500 homes annually. This report summarized the company's energy resource activities and presented an operations review as well as consolidated financial statements and common share information. This included the utility's assets, liabilities, revenues, expenses and cash flows. Revenue and expenditure statements were summarized by source. refs., tabs., figs

  18. Effect of HDL and apoAI on PGE2 Production by Monocyte-Derived Macrophages

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Summary: Effect of antiatherogenic high density lipoprotein (HDL) and apolipoprotein AI(apoAI) on production of prostaglandin E2(PGE2) by human monocyte-derived macrophages wasinvestigated. Macrophages were loaded with acetylated low density lipoprotein followed by incuba-tion with HDL3 or apoAI. PGE2 produced and secreted in culture supernatant was quantified by en-zyme immunoassay. HDL3 induced production of PGE2 by macrophages in a time-dependent man-ner. 24 h after incubation, PGE2 production by HDL3-treated macrophages increased 3. 7-fold ofthat by control cells. ApoAI also induced PGE2 secretion to 2. 1-fold, which was significantly lessthan HDL3. The data indicate that both HDL3 and lipid-free apoAI enhance PGE2 synthesis and se-cretion by human macrophages and this may further contribute to the protection from atheroscle-rosis.

  19. HDL Cholesterol Efflux Capacity: Cardiovascular Risk Factor and Potential Therapeutic Target.

    Science.gov (United States)

    Bhatt, Anish; Rohatgi, Anand

    2016-01-01

    Low high-density lipoprotein cholesterol (HDL-C) levels are associated with incident cardiovascular events; however, many therapies targeting increases in HDL-C have failed to show consistent clinical benefit. Thus, focus has recently shifted toward measuring high-density lipoprotein (HDL) function. HDL is the key mediator of reverse cholesterol transport, the process of cholesterol extraction from foam cells, and eventual excretion into the biliary system. Cholesterol efflux from peripheral macrophages to HDL particles has been associated with atherosclerosis in both animals and humans. We review the mechanism of cholesterol efflux and the emerging evidence on the association between cholesterol efflux capacity and cardiovascular disease in human studies. We also focus on the completed and ongoing trials of novel therapies targeting different aspects of HDL cholesterol efflux. PMID:26710794

  20. Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects

    DEFF Research Database (Denmark)

    Plomgaard, P; Dullaart, R P F; de Vries, R;

    2009-01-01

    -beta-HDL formation (r = 0.19; P = 0.02), even independently of positive relationships with apoA-I, HDL-cholesterol and PLTP activity. Cellular cholesterol efflux to plasma was positively related to pre-beta-HDL and PLTP activity but not significantly to apoM. CONCLUSIONS: Plasma apoM is modestly reduced in type 2...... 2 diabetes have reduced plasma apoM and whether apoM is associated with pre-beta-HDL formation and cellular cholesterol efflux. DESIGN: In 78 patients with type 2 diabetes and 89 control subjects, we measured plasma apoM with ELISA, pre-beta-HDL and pre-beta-HDL formation, phospholipid transfer...

  1. Effects of a lacto-ovo vegetarian diet on serum concentrations of cholesterol, triglyceride, HDL-C, HDL2-C, HDL3-C, apoprotein-B, and Lp(a).

    Science.gov (United States)

    Masarei, J R; Rouse, I L; Lynch, W J; Robertson, K; Vandongen, R; Beilin, L J

    1984-09-01

    The effect of intervention with a lacto-ovo vegetarian diet on serum concentrations of cholesterol, triglyceride, total high-density lipoprotein cholesterol (HDL-C), HDL2-C, HDL3-C, low-density lipoprotein cholesterol, apoprotein-B, apoprotein-HDL, and Lp(a) was studied in 19 men and 17 women. Most weekday meals were obtained from a single source and dietary records were completed to assess the changes in nutrient intakes. Blood was collected in the 6th wk of each dietary period. Because of strong correlations between many of the changes in nutrient intakes, principal component (factor) analysis was used followed by stepwise multiple regression analysis to identify associations between changes in diet and changes in lipid, lipoprotein or apoprotein levels. Three principal components accounted for 92.0% of the variation in lipid levels: factor 1 represented an increase in saturated fat, total fat, monounsaturated fat, cholesterol, and energy intake: factor 2 represented an increase in fiber and polyunsaturated fat, and decrease in protein intake; factor 3 an increase in total carbohydrate, complex carbohydrate, and energy intake. Where a change in a variable was significantly associated with change in diet, one factor appeared primarily responsible for the change; total cholesterol (factor 2, p = 0.034); triglyceride (factor 3, p = 0.005); apo-HDL (factor 1, p = 0.014); HDL2-C (factor 2, p = 0.023), HDL3-C (factor 3, p = 0.015). A borderline significant association was seen for total HDL-C (factor 2, p = 0.055). PMID:6089540

  2. A paradoxical severe decrease in serum HDL-cholesterol after treatment with a fibrate

    OpenAIRE

    Crook, M; Lynas, J; Wray, R

    2000-01-01

    There have been a handful of reports in the literature of a paradoxical decrease in serum high density lipoprotein (HDL)-cholesterol in patients on fibrate drugs. The reason for this decline in cardioprotective HDL-cholesterol is not known and may have potential deleterious effects on the patient. This report describes a decrease in serum HDL-cholesterol in a patient on both simvastatin and bezafibrate. This patient also developed abnormal renal function, probably interstitial nephritis. In a...

  3. An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration

    OpenAIRE

    Xun Chen, Charlotte Burton, Xuelei Song, Lesley Mcnamara, Annunziata Langella, Simona Cianetti, Ching H. Chang, Jun Wang

    2009-01-01

    Lecithin cholesterol acyltransferase (LCAT) plays a key role in the reverse cholesterol transport (RCT) process by converting cholesterol to cholesteryl ester to form mature HDL particles, which in turn deliver cholesterol back to the liver for excretion and catabolism. HDL levels in human plasma are negatively correlated with cardiovascular risk and HDL functions are believed to be more important in atheroprotection. This study investigates whether and how D-4F, an apolipoprotein A-I (apoA-I...

  4. Predictors of impaired HDL function in HIV-1 infected compared to uninfected individuals

    OpenAIRE

    Kelesidis, Theodoros

    2016-01-01

    Objective: HDL function rather than absolute level may be a more accurate indicator for cardiovascular disease (CVD) but it is unclear what drives HDL dysfunction in HIV-1 infection. The objective of this study is to identify factors that may contribute to HDL dysfunction in chronic HIV-1 infection. Design: Retrospective study of HIV-1 infected males with low overall CVD risk and healthy males with no known CVD risk matched by race to the HIV-1 infected participants. Methods: We related para...

  5. Studies on HDL associated enzymes under experimental hypercholesterolemia: possible modulation on selenium supplementation

    OpenAIRE

    Bansal Mohinder P; Kaur Harman D

    2009-01-01

    Abstract Background Atherosclerosis is a chronic disorder of the arterial wall that starts by formation of fatty streaks and gradually evolves into atherosclerotic plaques. High-density lipoproteins (HDL) blood levels are inversely correlated with atherosclerosis. This beneficial effect of HDL has been partly attributed to its antioxidant properties mediated by paraoxonase1 (PON1) or platelet-activating factor acetylhydrolase (PAF-AH). The present study was aimed to study HDL associated enzym...

  6. ApoA-I mutations, L202P and K131del, in HDL from heterozygotes with low HDL-C

    OpenAIRE

    Ljunggren, Stefan; Levels, Johannes H. M.; Turkina, Maria V.; Sundberg, Sofie; Bochem, Andrea E.; Hovingh, Kees; Holleboom, Adriaan G; Lindahl, Mats; Kuivenhoven, Jan Albert; Karlsson, Helen

    2014-01-01

    PURPOSE: Mutations in apolipoprotein A-I (apoA-I) may affect plasma high-density lipoprotein (HDL) cholesterol levels and the risk for cardiovascular disease but little is known about the presence and effects of circulating apoA-I variants. This study investigates whether the apoA-I mutations, apoA-I(L202P) and apoA-I(K131del) , are present on plasma HDL particles derived from heterozygote carriers and whether this is associated to changes in HDL protein composition. EXPERIMENTAL DESIGN: Plas...

  7. Automatic Circuit Extractor for HDL Description Using Program Slicing

    Institute of Scientific and Technical Information of China (English)

    Tun Li; Yang Guo; Si-Kun Li

    2004-01-01

    Design extraction and reduction have been extensively used in modern VLSI design process. The extracted and reduced design can be efficiently processed by various applications, such as formal verification,simulation, automatic test pattern generation (ATPG), etc. This paper presents a new circuit extraction method using program slicing technique, and develops an elegant theoretical basis based on program slicing for circuit extraction from Verilog description. The technique can obtain a chaining slice for given signals of interest. Compared with related researches, the main advantages of the method include that it is fine grain; it has no hardware description language (HDL) coding style limitation; it is precise and is capable of dealing with various Verilog constructions. The technique has been integrated with a commercial simulation environment and incorporated into a design process. The results of practical designs show the significant benefits of the approach.

  8. Advances in the Study of the Antiatherogenic Function and Novel Therapies for HDL

    Directory of Open Access Journals (Sweden)

    Peiqiu Cao

    2015-07-01

    Full Text Available The hypothesis that raising high-density lipoprotein cholesterol (HDL-C levels could improve the risk for cardiovascular disease (CVD is facing challenges. There is multitudinous clear clinical evidence that the latest failures of HDL-C-raising drugs show no clear association with risks for CVD. At the genetic level, recent research indicates that steady-state HDL-C concentrations may provide limited information regarding the potential antiatherogenic functions of HDL. It is evident that the newer strategies may replace therapeutic approaches to simply raise plasma HDL-C levels. There is an urgent need to identify an efficient biomarker that accurately predicts the increased risk of atherosclerosis (AS in patients and that may be used for exploring newer therapeutic targets. Studies from recent decades show that the composition, structure and function of circulating HDL are closely associated with high cardiovascular risk. A vast amount of data demonstrates that the most important mechanism through which HDL antagonizes AS involves the reverse cholesterol transport (RCT process. Clinical trials of drugs that specifically target HDL have so far proven disappointing, so it is necessary to carry out review on the HDL therapeutics.

  9. Comportamiento viscoso de lubricantes e altas presiones

    OpenAIRE

    Paredes Méndez, Xavier

    2012-01-01

    Esta Tesis Doctoral se centra en el estudio del comportamiento viscoso a alta presión de diferentes lubricantes de tipo mineral, vegetal y sintético. Cinco líquidos analizados a lo largo de este trabajo pueden ser usados como materiales de referencia para la calibración de viscosímetros a presión: di (2-etilhexil) sebacato, di (2-etilhexil) ftalato, diisodecilftalato, escualano y dipentaeritritol hexaisononanoato. Además se estudian cinco bases sintéticas para sistemas de refrigeración con di...

  10. Aprendizaje cooperativo con alumnos de altas capacidades

    OpenAIRE

    Herrera Lara, Inmaculada

    2016-01-01

    El presente Trabajo Fin de Grado tiene como finalidad conocer e investigar la intervención educativa que se lleva a cabo con los alumnos de altas capacidades a través del aprendizaje cooperativo. Estos alumnos necesitan de la ayuda y colaboración de los otros para lograr verdaderos procesos de aprendizaje. Sin la colaboración de docentes, padres y demás organismos del centro educativo no sería posible ofrecer una respuesta válida y eficaz a las necesidades que presenta este colectivo. Tal com...

  11. Subjects with low plasma HDL cholesterol levels are characterized by an inflammatory and oxidative phenotype.

    Directory of Open Access Journals (Sweden)

    Kirsten B Holven

    Full Text Available BACKGROUND: Epidemiological studies have shown that low plasma levels of high-density lipoprotein (HDL cholesterol are associated with increased risk of cardiovascular disease, but the mechanisms for the possible atheroprotective effects of HDL cholesterol have still not been fully clarified, in particular in relation to clinical studies. OBJECTIVE: To examine the inflammatory, anti-oxidative and metabolic phenotype of subjects with low plasma HDL cholesterol levels. METHODS AND RESULTS: Fifteen subjects with low HDL cholesterol levels (eleven males and four females and 19 subjects with high HDL (three males and 16 females were recruited. Low HDL cholesterol was defined as ≤10th age/sex specific percentile and high HDL-C was defined as ≥90 age/sex specific percentile. Inflammatory markers in circulation and PBMC gene expression of cholesterol efflux mediators were measured. Our main findings were: (i subjects with low plasma HDL cholesterol levels were characterized by increased plasma levels of CRP, MMP-9, neopterin, CXCL16 and ICAM-1 as well as low plasma levels of adiponectin, suggesting an inflammatory phenotype; (ii these individuals also had reduced paraoxonase (PON1 activity in plasma and PON2 gene expression in peripheral blood mononuclear cells (PBMC accompanied by increased plasma levels of oxidized LDL suggesting decreased anti-oxidative capacity; and (iii PBMC from low HDL subjects also had decreased mRNA levels of ABCA1 and ABCG1, suggesting impaired reverse cholesterol transport. CONCLUSION: Subjects with low plasma HDL cholesterol levels are characterized by an inflammatory and oxidative phenotype that could contribute to the increased risk of atherosclerotic disorders in these subjects with low HDL levels.

  12. procesos de alta temperatura en pymes

    Directory of Open Access Journals (Sweden)

    ANDRÉS AMELL

    2007-01-01

    Full Text Available La búsqueda de tecnologías de calentamiento que reduzcan el consumo de combustible, disminuyan las emisiones contaminantes y mejoren la productividad de los procesos y calidad de los productos en procesos de alta temperatura, ha motivado la investigación y desarrollo tecnológico de sistemas térmicos. En este contexto el artículo presenta los resultados del proyecto “Desarrollo y Evaluación de un Sistema de Combustión Autoregenerativo y Radiante para Procesos de Alta Temperatura en Pequeñas y Medianas Empresas PyMES”, presentando la configuración, funcionamiento, caracterización, parámetros de operación y comportamiento de un prototipo desarrollado que opera con 28 kW de potencia térmica con base al poder calorífico inferior, factores de aireación de 1.05 y 1.20 y temperaturas de precalentamiento de aire hasta de 700ºC.

  13. Utilização de filmes de polietileno de baixa densidade(PEBD) para prolongar a vida pós-colheita de morangos, cv. oso grande The use of low density polyethylene packing to prolong the postharvest life of 'oso grande' strawberries

    OpenAIRE

    Joel Donazzolo; Maurício Hunsche; Auri Brackmann; Alessandro Jaquiel Waclawovsky

    2003-01-01

    Desenvolveu-se um experimento com o objetivo de avaliar o efeito da atmosfera modificada (AM), utilizando filmes de polietileno de baixa densidade (PEBD), sobre a manutenção da qualidade de morangos (Fragaria ananassa L.), cv. Oso Grande, acondicionados em câmara frigorífica, a 0ºC, e em câmara de climatização, a 20ºC, simulando transporte/armazenamento refrigerado e o transporte/armazenamento convencional, sob altas temperaturas respectivamente. Os morangos foram acondicionados em bandejas p...

  14. Relation of FER-HDL and AIP to clinical and laboratory parameters in HATS

    Czech Academy of Sciences Publication Activity Database

    Dobiášová, Milada; Frohlich, J. J.; Brown, B.G.; Cheung, C.M.; Alaupovic, P.

    Elsevier. Roč. 6, č. 1 (2005), s. 50-50. ISSN 1567-5688. [Congress of the European Atherosclerosis Society /75./. 23.04.2005-26.04.2005, Prague] Institutional research plan: CEZ:AV0Z50110509 Keywords : FER -HDL * atherogenic index of plasma (AIP) * HDL-Atherosclerosis Treatment Study (HATS) Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

  15. Transporte de juvenis de curimbatá Prochilodus lineatus em diferentes densidades =Transportation of curimbata Prochilodus lineatus juveniles in different densities

    Directory of Open Access Journals (Sweden)

    André Fernando Nascimento Gonçalves

    2010-04-01

    Full Text Available Neste estudo foi avaliado o efeito do transporte de curimbatá Prochilodus lineatus, em três densidades (100, 150 e 250 g L-1, sobre a sobrevivência e variáveis metabólicas, iônicas e hematológicas (série vermelha. Juvenis de curimbatá foram transportados em sacos plásticos durante 6h e amostrados antes da embalagem, imediatamente após a chegada, 24 e 96h após o transporte. Os peixes transportados na densidade mais alta apresentaram maior mortalidade durante o período de recuperação. As variáveis físico-químicas da água: condutividade e amônia total apresentaram maiores valores quanto maior a densidade (p This study evaluated the effects of curimbata Prochilodus lineatus transportation in three densities (100, 150 and 250 g L-1 on survival, metabolic, ionic and hematological (red series variables. Curimbata juveniles were transported in plastic bag during six hours, and sampled before packing, immediately after the arrival, 24 and 96 hours after transportation. During recovery, higher mortality was seen in fish transported in the highest density. Water variables, such as conductivity and total ammonia, presented increased values as density increased (p < 0.05, whereas the opposite occurred with dissolved oxygen. Glucose level observed in the arrival was high, significantly reducing after 96 hours. Among ionic variables, chloride decreased in higher fish densities and according to sampling times. Red series hematological variables, such as hematocrit, red blood cell and hemoglobin, increased in arrival, but diminished 96 hours after transportation. There were no significant differences in the interaction between density and time of sampling for mentioned variables. 250 g L-1 density induced the highest mortality rate and the worst variables values measured. 96 hours of recovery after the stressing event was enough to return to initial values for hematological variables, but was not sufficient to return to initial values for

  16. A disposable electrochemical sensor based on protein G for High-Density Lipoprotein (HDL) detection.

    Science.gov (United States)

    Chammem, H; Hafaid, I; Bohli, N; Garcia, A; Meilhac, O; Abdelghani, A; Mora, L

    2015-11-01

    In this work, two biosensors were developed for the detection of High-Density Lipoproteins (HDL) particles, which are biomarkers inversely correlated with cardiovascular risk and which represent therapeutic targets for atherosclerosis. The electrochemical properties of the grafted antibody on interdigitated gold electrode were achieved by Impedance Spectroscopy (IS). The used deposition method was based on oriented antibody Anti-ApoA1 with an intermediate thin layer of protein G. The developed biosensor was able to detect both native plasma HDL and reconstituted HDL (rHDL) particles respectively with the detection limit of 50n g/mL and 1 ng/mL, respectively. Dynamic contact angle and atomic force microscopy were used. The developed biosensors are able to differentiate the HDL particles according to their differences in size and interactions with the immobilized antibody. PMID:26452849

  17. Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins.

    Science.gov (United States)

    Brandenburg, Klaus; Jürgens, Gudrun; Andrä, Jörg; Lindner, Buko; Koch, Michel H J; Blume, Alfred; Garidel, Patrick

    2002-12-01

    The interaction of bacterial endotoxins [lipopolysaccharide (LPS) and the 'endotoxic principle' lipid A], with high-density lipoprotein (HDL) from serum was investigated with a variety of physical techniques and biological assays. HDL exhibited an increase in the gel to liquid crystalline phase transition temperature Tc and a rigidification of the acyl chains of the endotoxins as measured by Fourier-transform infrared spectroscopy and differential scanning calorimetry. The functional groups of the endotoxins interacting with HDL are the phosphates and the diglucosamine backbone. The finding of phosphates as target groups is in accordance to measurements of the electrophoretic mobility showing that the zeta potential decreases from -50 to -60 mV to -20 mV at binding saturation. The importance of the sugar backbone as further target structure is in accordance with the remaining negative potential and competition experiments with polymyxin B (PMB) and phase transition data of the system PMB/dephosphorylated LPS. Furthermore, endotoxin binding to HDL influences the secondary structure of the latter manifesting in a change from a mixed alpha-helical/beta-sheet structure to a predominantly alpha-helical structure. The aggregate structure of the lipid A moiety of the endotoxins as determined by small-angle X-ray scattering shows a change of a unilamellar/inverted cubic into a multilamellar structure in the presence of HDL. Fluorescence resonance energy transfer data indicate an intercalation of pure HDL, and of [LPS]-[HDL] complexes into phospholipid liposomes. Furthermore, HDL may enhance the lipopolysaccharide-binding protein-induced intercalation of LPS into phospholipid liposomes. Parallel to these observations, the LPS-induced cytokine production of human mononuclear cells and the reactivity in the Limulus test are strongly reduced by the addition of HDL. These data allow to develop a model of the [endotoxin]/[HDL] interaction. PMID:12444987

  18. HDL Cholesterol and Cancer Risk Among Patients With Type 2 Diabetes

    Science.gov (United States)

    Zhao, Wenhui; Guan, Jing; Horswell, Ronald; Li, Weiqin; Wang, Yujie; Wu, Xiaocheng

    2014-01-01

    OBJECTIVE To investigate the relationship between HDL cholesterol (HDL-C) and cancer risk among type 2 diabetic patients. RESEARCH DESIGN AND METHODS We performed a retrospective cohort study of 14,169 men and 23,176 women with type 2 diabetes. Cox proportional hazards regression models were used to estimate the association of various levels of HDL cholesterol (HDL-C) with cancer risk. RESULTS During a mean follow-up period of 6.4 years, 3,711 type 2 diabetic patients had a cancer diagnosis. A significant inverse association between HDL-C and the risk of cancer was found among men and women. The multivariable-adjusted hazard ratios (HRs) of cancer at various levels of HDL-C at baseline (<30, 30–39.9, 40–49.9, 50–59.9, 60–69.9, 70–79.9, and ≥80 mg/dL) were 1.00, 0.87, 0.95, 1.01, 0.61, 0.45, and 0.37, respectively, in men (Ptrend = 0.027) and 1.00, 0.98, 0.88, 0.85, 0.84, 0.86, and 0.84, respectively, in women (Ptrend = 0.025). When stratified by race, BMI, smoking status, or medication use, the inverse association was still present. With an updated mean of HDL-C used in the analysis, the inverse association of HDL-C with cancer risk did not change. The inverse association substantially attenuated after excluding patients who died of or were diagnosed with cancer during the first 2 years of follow-up. CONCLUSIONS The study suggests an inverse association of HDL-C with cancer risk among men and women with type 2 diabetes, whereas the effect of HDL-C was partially mediated by reverse causation. PMID:25216507

  19. High efficiency motors; Motores de alta eficiencia

    Energy Technology Data Exchange (ETDEWEB)

    Uranga Favela, Ivan Jaime [Energia Controlada de Mexico, S. A. de C. V., Mexico, D. F. (Mexico)

    1992-12-31

    This paper is a technical-financial study of the high efficiency and super-premium motors. As it is widely known, more than 60% of the electrical energy generated in the country is used for the operation of motors, in industry as well as in commerce. Therefore the importance that the motors have in the efficient energy use. [Espanol] El presente trabajo es un estudio tecnico-financiero de los motores de alta eficiencia y los motores super premium. Como es ampliamente conocido, mas del 60% de la energia electrica generada en el pais, es utilizada para accionar motores, dentro de la industria y el comercio. De alli la importancia que los motores tienen en el uso eficiente de la energia.

  20. Estudio de la densidad mamográfica como modificador de riesgo de cáncer de mama en mujeres con mutación BRCA1/2

    OpenAIRE

    Tamayo Orjuela, Luisa Fernanda

    2015-01-01

    El cáncer de mama es el tumor más frecuente en la mujer y uno de los problemas de salud más importante por los índices de mortalidad y morbilidad asociados. Los factores de riesgo más frecuentes para desarrollar esta enfermedad son la historia familiar y la edad de la mujer. En un 5-10% de la población con cáncer de mama se detecta un tumor hereditario debido a una mutación heredada de los padres. Actualmente, la alta densidad mamográfica medida en las mamografías, se considera un factor ...

  1. World Wide Web Search Engines: AltaVista and Yahoo.

    Science.gov (United States)

    Machovec, George S., Ed.

    1996-01-01

    Examines the history, structure, and search capabilities of Internet search tools AltaVista and Yahoo. AltaVista provides relevance-ranked feedback on full-text searches. Yahoo indexes Web "citations" only but does organize information hierarchically into predefined categories. Yahoo has recently become a publicly held company and currently…

  2. Crecimiento de Colossoma macropomum en estanques de tierra en dependencia de la densidad.

    OpenAIRE

    Jorge Günther; Jorge Boza; Nazira Gálvez

    2016-01-01

    Se analiza el crecimiento y la utilización de alimento del tambaquí, Colossoma macropomum, cultivado a densidades de 0,5, 1 y 2 peces/m2 en estanques de tierra de 60m2 con alimento balanceado con 35% proteína. No se encontraron diferencias estadísticas significativas con respecto a la densidad. Sin embargo, el crecimiento obtenido fue mucho menor que en otro ensayo realizado en las mismas condiciones y simultáneamente en un estanque de 3000 m2, por lo que se discute la hipótesis de que el cre...

  3. Fitomassa de adubos verdes e controle de plantas daninhas em diferentes densidades populacionias de leguminosas.

    OpenAIRE

    Fernandes, Marcelo Ferreira; Barreto, Antônio Carlos; Emídio Filho, João

    1999-01-01

    O objetivo deste trabalho foi avaliar a fitomassa de calopogônio, mucuna-preta, mucunarajada,feijão-de-porco, guandu de porte alto, Crotalaria spectabilis e C. breviflora sob diferentes densidades de semeadura (10, 20, 40, 80 e 160 sementes viáveis m-2), e o crescimento de plantas daninhas nessas densidades, em área de tabuleiros costeiros. O experimento foi desenvolvido de maio a agosto de 1996, no Campo Experimental “Antônio Martins”(EMDAGRO/Embrapa-CPATC), em Lagarto, SE. O número de plant...

  4. Coenzyme O*U1*UO, Alpha-Tocopherol and Free Cholesterol in HDL and LDL Fractions

    DEFF Research Database (Denmark)

    Johansen, Kurt; Theorell, Henning; Karlsson, Jan; Diamant, Bertil; Folkers, Karl

    Farmakologi, Alpha-tocopherol, Coenzyme Q*U1*U0, free cholesterol, LDL, Antioxidants, Lipoproteins, HDL......Farmakologi, Alpha-tocopherol, Coenzyme Q*U1*U0, free cholesterol, LDL, Antioxidants, Lipoproteins, HDL...

  5. Therapies to Increase ApoA-I and HDL-Cholesterol Levels

    Directory of Open Access Journals (Sweden)

    William M. Brown

    2008-01-01

    Full Text Available Cholesterol is transported around the body in the form of lipoprotein (lipid/protein complexes, because it is almost insoluble in water. High-density lipoprotein (HDL particles transport cholesterol from tissues back to the liver for excretion. Epidemiological studies have shown an inverse relationship between blood levels of HDL-cholesterol (HDL-c and the incidence of clinically significant atherosclerosis. The beneficial effects of HDL in altering atherosclerotic disease are believed to involve elevated levels of HDL enhancing the efflux of cholesterol from arterial walls, increasing transport of cholesterol from arteries to the liver for excretion. This reverse cholesterol transport (RCT pathway is used to explain both HDL’s role in lipid metabolism and the inverse association between HDL-c plasma concentration and the risk of car- diovascular disease. Based on the RCT model, ApoA-I is an attractive target for therapeutic intervention. Experimental manipulations to increase production of ApoA-I have been associated with reduced atherogenicity. There is a continuing need for novel therapies that increase the biosynthesis of HDL, to inhibit the progression of and even bring about regression of atherosclerosis. Small molecule compounds that increase the production of endogenous ApoA-I would be attractive therapeutic agents for treating dyslipidemias.

  6. The macrophage and its related cholesterol efflux as a HDL function index in atherosclerosis.

    Science.gov (United States)

    Yamamoto, Suguru; Narita, Ichiei; Kotani, Kazuhiko

    2016-06-01

    The macrophage and its related cholesterol efflux are considered to be a key player in atherosclerotic formation in relation to the function of high-density lipoprotein (HDL). The HDL function can be evaluated by the reaction between lipid-loaded macrophages and lipid-acceptors in the HDL fraction from the plasma, apolipoprotein B-depleted serum, and/or whole serum/plasma. Recent studies have reported that an impaired cholesterol efflux of HDL is observed in patients with cardiometabolic diseases, such as dyslipidemia, diabetes mellitus, and chronic kidney disease. A population-based cohort study has reported an inverse association between the cholesterol efflux capacity of HDL and the incidence of atherosclerotic disease, regardless of the serum HDL-cholesterol level. Moreover, in this paper, when we summarized several clinical interventional studies of statin treatment that examined cholesterol efflux, a potential increase in the efflux in patients treated with statins was implied. However, the effect was not fully defined in the current situation because of the small sample sizes, lack of a unified protocol for measuring the efflux, and short-term intervention periods without cardiovascular outcomes in available studies. Further investigation is necessary to determine the effect of drugs on cholesterol efflux. With additional advanced studies, cholesterol efflux is a promising laboratory index to understand the HDL function. PMID:27087419

  7. Turismo em territórios de grande densidade religiosa

    Directory of Open Access Journals (Sweden)

    Siegrid Guillaumon

    2012-12-01

    Full Text Available Resumo ----- O turismo tem sido entendido por organismos internacionais como atividade com grande potencial para promover o desenvolvimento econômico e, ao mesmo tempo, que valoriza a cultura e promove a preservação das paisagens naturais. Seguindo as diretrizes internacionais, no Brasil, o turismo passou a ser entendido como uma indústria com grande potencial para gerar empregos e divisas, e se fortalece por meio da promoção da diversidade cultural, que pode estar associada às diversas culturas materiais e religiosas. Para compreender a gestão do turismo em contextos que articulam cultura, religião e desenvolvimento territorial, este ensaio teórico aponta limitações nos dois conceitos disponíveis na literatura, quais sejam, o conceito de turismo cultural e o conceito de turismo religioso, ao mesmo tempo que propõe o conceito de ‘turismo em territórios de grande densidade religiosa’, o qual incorpora o reconhecimento das dinâmicas de poder presentes nos territórios como elementos que interferem na forma como se planeja o turismo. Mobilizam-se entendimentos do campo da antropologia e da geografi a para a gestão a fim de sustentar que a discussão teórica conduzida tem um potencial explicativo para o turismo em diversas escalas territoriais, e, também, em contextos nos quais existe o diálogo entre turismo e religião. ----- Tourism in Territories of High Religious Density ----- Abstract ----- Tourism has been understood by international organizations as an activity with great potential to promote economic development, while valuing cultures and promoting the protection of natural landscapes. Following international guidelines, tourism in Brazil has begun to be understood as an industry with great potential to generate jobs and income and is strengthened through the promotion of cultural diversity which may be associated with material and religious cultures. To understand the management of tourism in contexts that

  8. Densidades de carga utilizadas para el transporte de bovinos destinados a matadero en Chile Stocking densities used to transport cattle to slaughter in Chile

    Directory of Open Access Journals (Sweden)

    C Gallo

    2005-01-01

    Full Text Available Se determinaron las densidades de carga empleadas en el transporte de 413 cargas (camionadas de bovinos, que comprendieron un total de 12.931 animales, recibidos en dos plantas faenadoras en Chile durante el año 2002, una en la X Región y la otra en la Región Metropolitana. Para las cargas recibidas en la planta de la X Región, las densidades de carga registradas fluctuaron entre 106 y 693 kg/m² (promedio 457 ± 6,6 kg/m² y en la Región Metropolitana fluctuaron entre 268 y 632 kg/m² (promedio 453 ± 9,7 kg/m². En ambas regiones se observó una tendencia a que las densidades de carga usadas en los vehículos de mayor tamaño (camiones simples y con carro fueran mayores; la mayoría de las cargas animales eran transportadas en este tipo de vehículo. Las densidades de carga encontradas para los viajes más largos no difirieron de aquellas usadas para los viajes cortos en el caso de la Región Metropolitana; sin embargo, en el caso de las cargas recibidas en la X Región se observó que en general los animales transportados por distancias más largas viajaron a densidades de carga mayores. En general, 32,4% de las 413 cargas revisadas, que correspondieron a 35,6% de todos los bovinos, sobrepasaron el límite de densidad de carga permitido por la legislación vigente (500 kg/m². Considerando que la literatura indica que el ganado bovino transportado a muy altas densidades, particularmente sobre 500 kg/m², sufre mayor estrés y produce inferior calidad de carne, especialmente en términos de mayor incidencia de contusiones, y que, además, en Chile las canales con contusiones que afectan el tejido muscular sufren una degradación en cuanto a la categoría de tipificación, reduciendo su valor económico, se recomienda, tanto desde el punto de vista de bienestar animal como de calidad de carne, al menos respetar el límite máximo de densidad de carga establecido para el transporte de ganado bovino en ChileThe stocking densities employed in

  9. Evaporation of carbon using electrons of a high density plasma; Evaporacion de carbono usando los electrones de un plasma de alta densidad

    Energy Technology Data Exchange (ETDEWEB)

    Muhl, S.; Camps, E.; Escobar A, L.; Garcia E, J.L.; Olea, O. [Instituto de Investigaciones en Materiales, UNAM, C.P. 04510 Mexico D.F. (Mexico)

    2000-07-01

    The high density plasmas are used frequently in the preparation of thin films or surface modification, for example to nitridation. In these processes, are used mainly the ions and the neutrals which compose the plasma. However, the electrons present in the plasma are not used, except in the case of chemical reactions induced by collisions, although the electron bombardment usually get hot the work piece. Through the adequate polarization of a conductor material, it is possible to extract electrons from a high density plasma at low pressure, that could be gotten the evaporation of this material. As result of the interaction between the plasma and the electron flux with the vapor produced, this last will be ionized. In this work, it is reported the use of this novelty arrangement to prepare carbon thin films using a high density argon plasma and a high purity graphite bar as material to evaporate. It has been used substrates outside plasma and immersed in the plasma. Also it has been reported the plasma characteristics (temperature and electron density, energy and ions flux), parameters of the deposit process (deposit rate and ion/neutral rate) as well as the properties of the films obtained (IR absorption spectra and UV/Vis, elemental analysis, hardness and refractive index). (Author)

  10. EFEITO DAS ALTAS DENSIDADES DE ESTOCAGEM NO CRESCIMENTO E SOBREVIVÊNCIA DE Litopenaeus vannamei NA FASE FINAL DE ENGORDA, CULTIVADOS EM SISTEMAS DE BIOFLOCOS (BFT

    Directory of Open Access Journals (Sweden)

    Adriana Ferreira Silva

    2013-09-01

    Full Text Available The aim of this study was to evaluate the effect of high stocking densities on survival, growth and feed conversion rates of Litopenaeus vannamei shrimp, in final growout phase, in a Biofloc Technology (BFT culture system, keeping the same water parameters for all treatments. Shrimps (11.96 ± 1.14 g were stocked in microcosms (0.50/m2 tanks, connected to a BFT system raceway. The study was carried out for 45 days. The shrimp were stocked at densities of 150, 300, 450 and 600 shrimp/m2. Bioflocs were collected for analysis of proximate composition. The results were submitted to one-way ANOVA, and differences were compared by Tukey test (α = 0.05. In T300 and T450, growth and survival were not affected by high stocking densities. The highest biomass reached (T450 was 5.1kg/m² and the best feed conversion rate was 1.54 in T150. The results of this study indicate that stocking densities in the proposed system can be high, but not exceeding 450 shrimp/m². Furthermore, even maintaining the same water parameters for all treatments, there was a negative effect between density and shrimp growth, confirming that this effect is behavioral.

  11. Characterization of composite high density polyethylene and layered zirconium phosphate; Caracterizacao de composito de polietileno de alta densidade (HDPE) e fosfato de zirconio lamelar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    Zirconium phosphate (ZrP) (2 w%), synthesized by direct precipitation method, was used in the preparation of composite with high density polyethylene (HDPE), through extrusion processing in the molten state. Wide angle x-ray diffraction (WAXD), stress-strain mechanical analysis and scanning electron microscopy (SEM) techniques were used for ZrP, neat polymer and composite mechanical and morphologic characterization. Although there was a slight increase in the Young modulus, WAXD and SEM analysis showed that the intercalation of the HDPE matrix in the filler galleries did not occur, probably due to the insufficient lamellae spacing to intercalate the polymer chains. Then, a microcomposite was achieved. (author)

  12. Role of HDL in cholesteryl ester metabolism of lipopolysaccharide-activated P388D1 macrophages[S

    OpenAIRE

    Uda, Sabrina; Spolitu, Stefano; Angius, Fabrizio; Collu, Maria; Accossu, Simonetta; Banni, Sebastiano; Murru, Elisabetta; Sanna, Francesca; Batetta, Barbara

    2013-01-01

    Infections share with atherosclerosis similar lipid alterations, with accumulation of cholesteryl esters (CEs) in activated macrophages and concomitant decrease of cholesterol-HDL (C-HDL). Yet the precise role of HDL during microbial infection has not been fully elucidated. Activation of P388D1 by lipopolysaccharide (LPS) triggered an increase of CEs and neutral lipid contents, along with a remarkable enhancement in 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate-HDL uptake...

  13. PLTP activity in premenopausal women. Relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance.

    Science.gov (United States)

    Murdoch, S J; Carr, M C; Hokanson, J E; Brunzell, J D; Albers, J J

    2000-02-01

    Plasma phospholipid transfer protein (PLTP) is thought to play a major role in the facilitated transfer of phospholipids between lipoproteins and in the modulation of high density lipoprotein (HDL) particle size and composition. However, little has been reported concerning the relationships of PLTP with plasma lipoprotein parameters, lipolytic enzymes, body fat distribution, insulin, and glucose in normolipidemic individuals, particularly females. In the present study, 50 normolipidemic healthy premenopausal females were investigated. The relationships between the plasma PLTP activity and selected variables were assessed. PLTP activity was significantly and positively correlated with low density lipoprotein (LDL) cholesterol (r(s) = 0.53), apoB (r(s) = 0.44), glucose (r(s) = 0.40), HDL cholesterol (r(s) = 0.38), HDL(3) cholesterol (r(s) = 0.37), lipoprotein lipase activity (r(s) = 0.36), insulin (r(s) = 0.33), subcutaneous abdominal fat (r(s) = 0.36), intra-abdominal fat (r(s) = 0.29), and body mass index (r(s) = 0.29). HDL(2) cholesterol, triglyceride, and hepatic lipase were not significantly related to PLTP activity. As HDL(2) can be decreased by hepatic lipase and hepatic lipase is increased in obesity with increasing intra-abdominal fat, the participants were divided into sub-groups of non-obese (n = 35) and obese (n = 15) individuals and the correlation of PLTP with HDL(2) cholesterol was re-examined. In the non-obese subjects, HDL(2) cholesterol was found to be significantly and positively related to PLTP activity (r(s) = 0.44). Adjustment of the HDL(2) values for the effect of hepatic lipase activity resulted in a significant positive correlation between PLTP and HDL(2) (r(s) = 0.41), indicating that the strength of the relationship between PLTP activity and HDL(2) can be reduced by the opposing effect of hepatic lipase on HDL(2) concentrations. We conclude that PLTP-facilitated lipid transfer activity is related to HDL and LDL metabolism, as well as

  14. P2Y13 Receptor Regulates HDL Metabolism and Atherosclerosis In Vivo

    OpenAIRE

    Goffinet, Marine; Tardy, Claudine; Boubekeur, Nadia; Cholez, Guy; Bluteau, Alice; Oniciu, Daniela C.; Lalwani, Narendra D.; Dasseux, Jean-Louis H.; Barbaras, Ronald; Baron, Rudi

    2014-01-01

    High-density lipoprotein (HDL) is known to protect against atherosclerosis by promoting the reverse cholesterol transport. A new pathway for the regulation of HDL-cholesterol (HDL-c) removal involving F1-ATPase and P2Y13 receptor (P2Y13R) was described in vitro, and recently in mice. However, the physiological role of F1-ATPase/P2Y13R pathway in the modulation of vascular pathology i.e. in the development of atherosclerotic plaques is still unknown. We designed a specific novel agonist (CT100...

  15. Intracellular cholesterol transport proteins enhance hydrolysis of HDL-CEs and facilitate elimination of cholesterol into bile.

    Science.gov (United States)

    Wang, Jing; Bie, Jinghua; Ghosh, Shobha

    2016-09-01

    While HDL-associated unesterified or free cholesterol (FC) is thought to be rapidly secreted into the bile, the fate of HDL-associated cholesteryl esters (HDL-CEs) that represent >80% of HDL-cholesterol, is only beginning to be understood. In the present study, we examined the hypothesis that intracellular cholesterol transport proteins [sterol carrier protein 2 (SCP2) and fatty acid binding protein-1 (FABP1)] not only facilitate CE hydrolase-mediated hydrolysis of HDL-CEs, but also enhance elimination of cholesterol into bile. Adenovirus-mediated overexpression of FABP1 or SCP2 in primary hepatocytes significantly increased hydrolysis of HDL-[(3)H]CE, reduced resecretion of HDL-CE-derived FC as nascent HDL, and increased its secretion as bile acids. Consistently, the flux of [(3)H]cholesterol from HDL-[(3)H]CE to biliary bile acids was increased by overexpression of SCP2 or FABP1 in vivo and reduced in SCP2(-/-) mice. Increased flux of HDL-[(3)H]CE to biliary FC was noted with FABP1 overexpression and in SCP2(-/-) mice that have increased FABP1 expression. Lack of a significant decrease in the flux of HDL-[(3)H]CE to biliary FC or bile acids in FABP1(-/-) mice indicates the likely compensation of its function by an as yet unidentified mechanism. Taken together, these studies demonstrate that FABP1 and SCP2 facilitate the preferential movement of HDL-CEs to bile for final elimination. PMID:27381048

  16. Where Are We With HDL Raising and Inhibition of Cholesteryl Ester Transfer for Heart Disease Risk Reduction?

    Science.gov (United States)

    Purpose: To review recent research in the area of high density lipoprotein (HDL) raising and coronary heart disease (CHD) risk reduction. Recent Findings: It is known that a decreased HDL cholesterol is an important CHD risk factor, and that raising HDL cholesterol has been associated with CHD risk...

  17. Elevando el colesterol HDL: ¿Cuál es la mejor estrategia? Raising HDL cholesterol: which is the best strategy?

    OpenAIRE

    John Edwin Feliciano Alfonso; Iván Darío Sierra Ariza

    2008-01-01

    Após atingir as metas para os níveis de LDL-colesterol, é imperativo alcançar a meta do HDL-colesterol, por suas conhecidas propriedades antiaterogênicas confirmadas amplamente em muitos estudos epidemiológicos. Esta revisão analisa de maneira objetiva e concisa as diversas alternativas disponíveis na prática clínica diária para aumentar os níveis de HDL-colesterol em nosoos pacientes, com o objetivo de alcançar melhores prognósticos em termos de morbimortalidade cardiovascular.After having r...

  18. Operador de densidad y operadores producto en resonancia magnética nuclear

    OpenAIRE

    Paniagua, Juan Carlos

    2015-01-01

    Breve introducción al formalismo del operador de densidad y su aplicación a la resonancia magnética nuclear. Incluye el método de los operadores producto para analizar la evolución de sistemas de espines.

  19. How much does HDL cholesterol add to risk estimation? A report from the SCORE Investigators.

    LENUS (Irish Health Repository)

    Cooney, Marie Therese

    2009-06-01

    Systematic COronary Risk Evaluation (SCORE), the risk estimation system recommended by the European guidelines on cardiovascular disease prevention, estimates 10-year risk of cardiovascular disease mortality based on age, sex, country of origin, systolic blood pressure, smoking status and either total cholesterol (TC) or TC\\/high-density lipoprotein cholesterol (HDL-C) ratio. As, counterintuitively, these two systems perform very similarly, we have investigated whether incorporating HDL-C and TC as separate variables improves risk estimation.

  20. Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)–deficient mice

    OpenAIRE

    Miettinen, Helena E.; Rayburn, Helen; Krieger, Monty

    2001-01-01

    Mammalian female fertility depends on complex interactions between the ovary and the extraovarian environment (e.g., the hypothalamic-hypophyseal ovarian axis). The role of plasma lipoproteins in fertility was examined using HDL-receptor SR-BI knockout (KO) mice. SR-BI KO females have abnormal HDLs, ovulate dysfunctional oocytes, and are infertile. Fertility was restored when the structure and/or quantity of abnormal HDL was altered by inactivating the apoAI gene or administering the choleste...

  1. Relationship TG/HDL-C and insulin resistance in adult women by nutritional status

    Directory of Open Access Journals (Sweden)

    Lorena Belén

    2014-04-01

    Full Text Available Introduction: The ratio assessment TG/HDL-C is an indicator of LDL size, facilitating the detection of individuals with increased atherogenic risk. Estimating the size of the LDL becomes important, especially in patients with TG values near the upper limit of normal values of reference and HDL-C. The objective of the study is to estimate the association between TG/HDL-C and insulin resistance (IR by nutritional status in adult women attending the Foundation for Endocrine Metabolic Diseases Research and Applied Clinical Research (FIEEM.Material and methods: Design Cross-sectional, non-pregnant adult women, apparently healthy, older than 30 years old, attending FIEEM in the Autonomous City of Buenos Aires. Dependent variable: TG/HDL-C ≥ 3.0 considered high value. Independent variables: IR by homeostatic model index HOMA-IR ≥ 2.5 categorizing the sample into two groups: with and without IR, and controlled by nutritional status using body mass index (BMI and waist circumference (CC. SPSS Statistics 15.0, calculating X2 or Fisher exact test, OR with confidence intervals of 95% and establishing logistic regression p value < 0.05.Results: We evaluated a purposive sample of 104 women (31.4% and 26% IR with TG/HDL-C high. 84.6% were overweight or obese and 88.5% increased CC. Women with BMI had significantly increased 0.15-fold increased risk (95% CI = 0.01 to 1.26 for TG/HDL-C high (p = 0.04 than the control women. There was no significance with increased CC. The ratio TG/HDL-C high IR was significantly correlated (r = 0.30 p = 0.002.Conclusions: Body weight was significantly associated with IR and the ratio TG/HDL-C increased. This ratio correlated significantly with IR in apparently healthy women.

  2. Lipoprotein (a) in type 2 diabetes mellitus: Relation to LDL:HDL ratio and glycemic control

    OpenAIRE

    Singla, Seema; Kaur, Kiranjeet; Kaur, Gurdeep; Kaur, Habir; Kaur, Jasbinder; Jaswal, Shivani

    2009-01-01

    BACKGROUND: Increased lipoprotein (a) [Lp (a)] concentrations are predictive of coronary artery disease (CAD). Type 2 diabetes mellitus also leads to dyslipidemia, like elevated triglyceride levels and low HDL levels, which are known risk factors for CAD. This study was designed to investigate the levels of Lp (a) in type 2 diabetic patients and their association with LDL: HDL ratio and glycemic control. MATERIALS AND METHODS: The study included 60 patients of type 2 diabetes and 50 age and s...

  3. Cost Effectiveness of Treating Low HDL-Cholesterol in the Primary Prevention of Coronary Heart Disease

    OpenAIRE

    Joel W. Hay; Kimberly L. Sterling

    2005-01-01

    Background: A low serum level of high-density lipoprotein (HDL)-cholesterol is an independent risk factor for coronary heart disease (CHD). Fibrates, particularly gemfibrozil, have been shown to raise HDL-cholesterol levels and reduce the incidence of CHD. The literature on fibrate cost effectiveness is quite limited. Objective: The objective of this analysis is to determine the cost effectiveness of the fibrates gemfibrozil and fenofibrate in the primary prevention of CHD. The target populat...

  4. Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes

    OpenAIRE

    Storey, Stephen M.; McIntosh, Avery L.; Huang, Huan; Landrock, Kerstin K.; Martin, Gregory G.; Landrock, Danilo; Payne, H. Ross; Atshaves, Barbara P.; Kier, Ann B.; Schroeder, Friedhelm

    2012-01-01

    A major gap in our knowledge of rapid hepatic HDL cholesterol clearance is the role of key intracellular factors that influence this process. Although the reverse cholesterol transport pathway targets HDL to the liver for net elimination of free cholesterol from the body, molecular details governing cholesterol uptake into hepatocytes are not completely understood. Therefore, the effects of sterol carrier protein (SCP)-2 and liver fatty acid-binding protein (L-FABP), high-af...

  5. Relations between particle size of HDL and LDL lipoproteins and cholesterol esterification rate

    Czech Academy of Sciences Publication Activity Database

    Dobiášová, Milada; Urbanová, Z.; Šamánek, M.

    2005-01-01

    Roč. 54, č. 2 (2005), s. 159-165. ISSN 0862-8408 R&D Projects: GA MZd(CZ) NA6590; GA MZd(CZ) NR8328 Institutional research plan: CEZ:AV0Z5011922 Keywords : particle size of lipoproteins * FER (HDL) * Log(TG/HDL-C) Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 1.806, year: 2005

  6. Efeito da densidade de estocagem no desenvolvimento inicial do acará-bandeira (Pterophyllum scalare

    Directory of Open Access Journals (Sweden)

    L.P. Gonçalves Júnior

    2013-08-01

    Full Text Available Avaliou-se a influência da densidade de estocagem no desenvolvimento inicial do acará-bandeira (Pterophyllum scalare. O desempenho produtivo foi avaliado pelo ganho de peso (GP, ganho de comprimento total (GCT, ganho de comprimento padrão (GCP, ganho de altura (GA, taxa de crescimento específico (TCE, taxa de desenvolvimento específico (TDE e sobrevivência (S. Para realização do experimento, foram utilizadas 300 pós-larvas de peso médio inicial de 0,0012g, comprimento total médio de 4,11±0,93mm, altura média inicial de 4,84±0,87mm e comprimento padrão médio de 1,54±0,25mm. Essas foram distribuídas em delineamento inteiramente ao acaso, em cinco tratamentos com quatro repetições. Os tratamentos (T foram constituídos por cinco diferentes densidades de estocagem, em que T1: 5 pós-larvas L-1; T2: 10 pós-larvas L-1; T3: 15 pós-larvas L-1; T4: 20 pós-larvas L-1; T5: 25 pós-larvas L-1. A densidade de 5 pós-larvas L-1 foi a que proporcionou o maior valor para crescimento. Contudo, essa densidade subestimou a utilização do espaço se comparada com a produtividade final da densidade de 15 pós-larvas L-1.

  7. Comportamento de cultivares de cafeeiro em diferentes densidades de plantio The behavior of coffee cultivars under different plant densities

    Directory of Open Access Journals (Sweden)

    Edison Martins Paulo

    2005-01-01

    Full Text Available Avaliou-se em Adamantina, na Região da Alta Paulista, em São Paulo, entre maio de 1995 e junho de 2000, o crescimento e quatro produções de cafeeiros das cultivares de porte baixo Catuaí Amarelo IAC 47 e Obatã IAC 1669-20 de Coffea arabica L., submetidas às densidades de plantio de 2.500, 5.000, 7.519 e 10.000 plantas ha-1, com uma planta por cova. Estudou-se também a população de 2.500 plantas.ha-1 em covas com duas plantas com 2,0 m de distância na linha de plantio. Adotou-se o delineamento estatístico de blocos ao acaso com três repetições, com parcelas subdivididas, onde as parcelas foram as populações e as subparcelas, as cultivares. Os resultados permitiram inferir que, no período estudado, o aumento da densidade influenciou positivamente a altura e negativamente o diâmetro do caule e da base da copa dos cafeeiros, mas não a altura da inserção do primeiro ramo plagiotrópico a partir do nível do solo. O aumento da população de cafeeiros acarretou menor produção de café beneficiado por planta, mas concorreu para o aumento da produtividade no período de 1997 a 2000. O plantio de duas mudas de café por cova acarretou também diminuição do diâmetro do caule e da produção individual dos cafeeiros. Observou-se na cultivar Catuaí Amarelo IAC 47 maior diâmetro da base da copa e maior crescimento em altura, enquanto a cv. Obatã IAC 1669-20 evidenciou seu maior diâmetro do caule. As cultivares Catuaí Amarelo IAC 47 e Obatã IAC 1669-20 não diferiram entre si quanto à produção individual e à produtividade de café beneficiado no quadriênio (1997-2000.This experiment was developed at Adamantina, west region of the State of São Paulo, Brazil, during May of 1995 to June of 2000. The plant growth and productivity of two coffee cultivars Catuaí Amarelo IAC 47 and Obatã IAC 1669-20, were evaluated considering to plant densities of 2.500, 5.000, 7.519 and 10.000 plants ha-1. The density of 2500 also was

  8. Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

    Directory of Open Access Journals (Sweden)

    Andriy L. Zagayko

    2013-01-01

    Full Text Available HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from “Enoant” obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON and lecithin:cholesterol acyltransferase (LCAT activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After “Enoant” administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats.

  9. Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events

    Directory of Open Access Journals (Sweden)

    Sung Woo Cho

    2016-01-01

    Full Text Available Abstract Background: Hemorheological and glycemic parameters and high density lipoprotein (HDL cholesterol are used as biomarkers of atherosclerosis and thrombosis. Objective: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR, fibrinogen, fasting glucose, glycated hemoglobin (HbA1c, and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE and coronary heart disease (CHD in an outpatient population. Methods: 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. Results: Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Conclusion: Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients.

  10. HIV-1 infected patients with suppressed plasma viremia on treatment have pro-inflammatory HDL

    Directory of Open Access Journals (Sweden)

    Navab Kaveh

    2011-02-01

    Full Text Available Abstract Background The role of pro-inflammatory lipids in systemic immune activation in HIV infection remains largely unknown. We hypothesized that HIV-1-infected persons on antiretroviral therapy would have pro-inflammatory high density lipoprotein (HDL, and that an apoA-1 mimetic peptide might reverse the inflammatory properties of HDL in these persons. Methods Plasma was obtained from 10 HIV-1-infected individuals on combination antiretroviral therapy with suppressed viremia and was incubated with the apoA-I mimetic peptide L-4F or sham-treated prior to isolation of HDL. The HDL that was isolated from each sample was tested for its ability to inhibit LDL-induced MCP-1 production in cultures of human aortic endothelial cells. Results We found in a small pilot study of HIV-1-infected individuals with suppressed viremia on combination antiretroviral therapy that oxidative stress and inflammation in HIV-1 are associated with a marked reduction of HDL antioxidant/anti-inflammatory activities. In vitro, these abnormalities were significantly improved by treatment with the apoA-1 mimetic peptide, 4F. Conclusions These preliminary observations suggest that the anti-inflammatory properties of HDL are defective in HIV-1-infected persons despite treatment that is considered to be virologically successful.

  11. Elevando el colesterol HDL: ¿Cuál es la mejor estrategia? Raising HDL cholesterol: which is the best strategy?

    Directory of Open Access Journals (Sweden)

    John Edwin Feliciano Alfonso

    2008-08-01

    Full Text Available Após atingir as metas para os níveis de LDL-colesterol, é imperativo alcançar a meta do HDL-colesterol, por suas conhecidas propriedades antiaterogênicas confirmadas amplamente em muitos estudos epidemiológicos. Esta revisão analisa de maneira objetiva e concisa as diversas alternativas disponíveis na prática clínica diária para aumentar os níveis de HDL-colesterol em nosoos pacientes, com o objetivo de alcançar melhores prognósticos em termos de morbimortalidade cardiovascular.After having reached the objective for the LDL cholesterol levels, it becomes imperative to reach the objective for HDL cholesterol, known for its anti-atherogenic properties, generally confirmed in many epidemiological studies. This review deals, in a clear and concise manner, with the different alternatives available in daily clinical practice to raise the HDL cholesterol levels of patients, to achieve better outcomes in terms of morbidity and mortality in cardiovascular disease.

  12. Hubungan Kadar LDL dan HDL Serum Ibu Hamil Aterm dengan Berat Lahir Bayi

    Directory of Open Access Journals (Sweden)

    Oktalia Sabrida

    2014-09-01

    Full Text Available AbstrakAda anyak penelitian yang membuktikan transfer kolesterol dari ibu ke janin melalui lapisan trofoblas yang membawa partikel LDL (Low Density Lipoprotein dan HDL (High Density Lipoprotein. Pengambilan dan pemanfaatan LDL oleh plasenta merupakan mekanisme alternatif oleh janin untuk memperoleh asam lemak dan asam amino esensial. Tujuan penelitian ini untuk mengetahui hubungan kadar LDL dan HDL serum ibu hamil aterm dengan berat lahir bayi. Penelitian ini merupakan studi observasional dengan rancangan cross sectional. Dilakukan pemeriksaan kadar LDL dan HDL serum terhadap 31 sampel ibu hamil aterm yang dipilih secara consecutive sampling, kemudiaan saat bayi dari sampel lahir dilakukan penimbangan berat lahir bayi dalam 1 jam setelah lahir dengan keadaan tanpa pakaian. Data dianalisis menggunakan uji korelasi Pearson dilanjutkan dengan uji regresi linier sederhana, nilai p<0.05 dianggap bermakna secara statistik. Rerata kadar LDL serum ibu hamil aterm 138,52±37,86 mg/dl dengan 7 sampel (22,60% kadar LDL <101 mg/dl. Rerata kadar HDL serum ibu hamil aterm 53,32±17,39 mg/dl dengan 13 sampel (41,90% kadar HDL <48 mg/dl. Rerata berat lahir bayi 3150,00±489,89 gram dengan 2 sampel (6,50% memiliki bayi dengan berat<2500 gram. Terdapat hubungan positif antara kadar LDL serum ibu hamil aterm dengan berat lahir bayi, kekuatan hubungan lemah (r=0,258, secara statistik tidak bermakna (p=0,161. Terdapat hubungan positif antara kadar HDL serum ibu hamil aterm, kekuatan hubungan sangat lemah (r=0,035, secara statistik tidak bermakna (p=0,850. Kesimpulan penelitian tidak terdapat hubungan kadar LDL dan HDL serum ibu hamil dengan berat lahir bayi.Kata kunci: kadar LDL serum, kadar HDL serum, ibu hamil aterm, berat lahir bayiAbstractMany studies proved that the transferring of cholesterol from mother to fetus through the trophoblastic layer carried LDL (Low Density Lipoprotein and HDL (High Density Lipoprotein particles. Uptake and usage of LDL by placenta

  13. Perbedaan Rasio Kolesterol Total/ HDL Kelompok Kontrol dan Kelompok Diet Tinggi Minyak Sawit pada Tikus Wistar

    Directory of Open Access Journals (Sweden)

    Yelsa Yulanda Putri

    2014-09-01

    Full Text Available AbstrakRasio kolesterol total/ HDL merupakan variabel lipoprotein terbaik dalam memprediksi risiko penyakit kardiovaskular. Peningkatan risiko penyakit kardiovaskular dapat disebabkan oleh tingginya kadar kolesterol serum. Minyak sawit mengandung 50% asam lemak jenuh dan 50% asam lemak tidak jenuh. Tujuan penelitian ini adalah mengetahui perbedaan rasio kolesterol total/ HDL antara kelompok kontrol dengan kelompok diet tinggi minyak sawit pada tikus. Penelitian ini adalah eksperimental dengan pendekatan post test only control group design. Sampel penelitian terdiri dari 10 ekor tikus Wistar jantan yang dibagi menjadi kelompok kontrol (K dan kelompok perlakuan (P. Diet tinggi minyak sawit (minyak sawit 42.5%, 3ml/hari diberikan pada kelompok P selama empat minggu. Analisis data menggunakan uji t independent. Hasil penelitian menunjukkan terdapat perbedaan peningkatan yang tidak bermakna antara kelompok P dan kelompok K pada rerata kolesterol, yaitu 63.66±9.9(P 57.39±3.28(K (p>0.05, rerata HDL 19.44±3.99(P 17.64±2.00(K (p>0.05, dan rerata rasio kolesterol total/ HDL 3.26±0.24 (P 3.31±0.32 (K (p>0.05. Kesimpulan penelitian ini adalah kadar kolesterol total, HDL, dan rasio kolesterol total/ HDL pada kelompok kontrol dan kelompok diet tinggi minyak sawit tidak berbeda.Kata kunci: diet tinggi minyak sawit, kolesterol, HDL, rasio kolesterol/ HDLAbstractThe ratio of total cholesterol/ HDL is the lipoprotein variables best predict the risk of cardiovascular disease . The increased risk of cardiovascular disease can be caused by high levels of cholesterol exciting. Palm oil contains 50% saturated fatty acids and 50% unsaturated fatty acids. The purpose of this study was to know the differences ratio of total cholesterol/ HDL between the control group and high palm oil diet group in rats. This research was experimental with post-test only control group. The study sample consisted of 10 male Wistar rats were divided into control group (K and treated

  14. High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease

    Directory of Open Access Journals (Sweden)

    Protasio Lemos da Luz

    2008-01-01

    Full Text Available An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c indicates an atherogenic lipid profile and a risk for the development of coronary disease. OBJECTIVE: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease. METHODS: High-risk patients (n = 374 submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index. RESULTS: The subjects consisted of 220 males and 154 females, age 57.2 ± 11.1 years, with total cholesterol of 210± 50.3 mg/dL, triglycerides of 173.8 ± 169.8 mg/dL, HDL-cholesterol (HDL-c of 40.1 ± 12.8 mg/dL, LDL-cholesterol (LDL-c of 137.3 ± 46.2 mg/dL, TG/HDL-c of 5.1 ± 5.3, and a Friesinger index of 6.6 ± 4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31-3.1; p = 0.0018; HDL-c, odds ratio of 2.21 (1.42-3.43; p = 0.0005; and TG/HDL-c, odds ratio of 2.01(1.30-3.09; p = 0.0018. However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p = 0.33] or LDL-c [1.47 (0.96-2.25; p = 0.0842]. The chi-square for linear trends for Friesinger > 4 and lipid quartiles was statistically significant for triglycerides (p = 0.0017, HDL-c (p = 0.0001, and TG/HDL-c (p = 0.0018, but not for total cholesterol (p = 0.393 or LDL-c (p = 0.0568. The multivariate analysis by logistic regression OR gave 1.3 ± 0.79 (p = .0001 for TG/HDL-c, 0.779 ± 0.074 (p = .0001 for HDL-c, and 1.234 ± 0.097 (p = 0.03 for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease. CONCLUSIONS: Although some lipid variables were associated with the extent of

  15. Alta Capital venitab Kruudale tasumisega / Sten-Aleks Pihlak

    Index Scriptorium Estoniae

    Pihlak, Sten-Aleks

    2008-01-01

    Alta Capital Partnersid pole veel maksnud Oliver Kruudale 2007. aasta septembris müüdud Tere ja Kalevi eest. Vt. samas: Rahasaamise venimine on lükanud Kalevi viimastel kuudel laenurallile. Kommenteerib Aivar Häelm

  16. A densidade básica e característica anatômicas variam radialmente na madeira de Astronium graveolens Jacq. (Anacardiaceae. Basic density and anatomical features vary in the radial direction in the wood of Astronium graveolens Jacq. (Anacardiaceae.

    Directory of Open Access Journals (Sweden)

    Camila Moura SANTOS

    2011-12-01

    Full Text Available Estudos sobre variações nas dimensões celulares de espécies arbóreas de clima tropical são escassos. Sendo assim, o objetivo deste trabalho foi caracterizar a variação da densidade básica e da anatomia no sentido radial da madeira de Astronium graveolens Jacq. Coletaram-se cinco indivíduos da espécie, provenientes da Estação Experimental Luiz Antônio (SP. Os métodos empregados nas análises foram os usualmente utilizados em pesquisas de densidade e anatomia de madeira. De acordo com os resultados foram constatadas altas correlações entre densidade básica, comprimento de fibra, espessura da parede da fibra, diâmetro de vaso e frequência de vaso com a distância da medula. A densidade básica da madeira é altamente dependente do comprimento das fibras, espessura da parede das fibras e diâmetro dos vasos, ocorrendo aumento no sentido da medula para a casca.Studies on variations in cell sizes of tree species in tropical climate are scarce. Thus, the aim was characterize the radial variation of basic density and wood anatomy of Astronium graveolens Jacq. Five specimens were collected at the Luiz Antônio Experimental Station,(SP. Sstandard methods for studying the density and wood anatomy were employed. According to the results we observed high correlation among basic density,fiber length, fiber wall thickness, vessel diameter and vessel frequency with distance fromthe pith. The wood density is highly dependent on fiber length, fiber wall thicknessand vessel diameter, there was an increase towards the pith to bark.

  17. Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China

    Directory of Open Access Journals (Sweden)

    Ming-hong Yao

    2016-01-01

    Full Text Available Objective: To detect the interactions between six functional polymorphisms in ABCA1 and obesity in Kazakhs with low HDL-C levels. Methods: A total of 204 patients with low HDL-C and 207 health control subjects, which were randomly selected from among 5692 adult Kazakhs, were matched for age and sex. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313. Results: (1 The genotypic and allelic frequencies of rs2515602, rs2230806 and rs4149313 were different between normal HDL-C and low HDL-C subjects, the genotypic frequency of rs2275542 was also different between normal HDL-C and low HDL-C subjects (p < 0.05; (2 the level of HDL-C (rs2515602 and rs2275542 in normal HDL-C subjects were different among the genotypes (p < 0.05; the levels of TC, LDL-C (rs2515602, rs4149313; TG (rs2515602, rs1800976, rs4149313 in low HDL-C patients were different among the genotypes (p < 0.05; (3 interactions between the rs3890182, rs2275542, rs180096, and rs4149313 polymorphisms in ABCA1 gene and obesity may be associated with low HDL-C disease; (4 the C-C-C-A-A-G, T-C-C-A-A-A, T-C-C-A-A-G, C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes were significant between the subjects with normal HDL-C and low HDL-C level (p < 0.05. Conclusions: The differences in serum lipid levels between normal HDL-C and low HDL-C subjects among Kazakhs might partly result from ABCA1 gene polymorphisms; ABCA1 gene polymorphisms may be associated with low HDL-C disease; the low HDL-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity; the C-C-C-A-A-G, T-C-C-A-A-A, and T-C-C-A-A-G haplotypes may serve as risk factors of low HDL-C disease among Kazakhs, the C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes may serve as protective factor of low HDL-C disease among Kazakhs.

  18. Low serum hdl-c levels: a hidden threat to patients with spinal cord injury

    International Nuclear Information System (INIS)

    To determine the serum lipid profile in patients with traumatic spinal cord injury (SCI) of duration >1 year and to compare the serum HDL-c levels of SCI patients undergoing regular physiotherapy for >60 minutes daily with those who did not Undergo physiotherapy. Study Design: Cross-sectional, comparative study. Place and Duration of Study: Spinal Cord Injury Department, AFIRM Rawalpindi and Department of Chemical Pathology, Army Medical College, Rawalpindi, from January 2013 to June 2013. Patients and Methods: Forty six patients suffering from traumatic spinal cord injury (SCI) were included. After recording the detailed medical history, fasting blood samples were obtained and analyzed for serum lipid profile. Dyslipidemias were assessed using guidelines from the National Cholesterol Education Project Adult Treatment Panel III (ATP III). Serum high-density lipoprotein cholesterol (HDL-c)< 0.9 mmol/l (40mg/dl) was considered as low HDL-c level. Results: Out of total 46 patients, 33 (71.7%) were male and 13 (28.3%) were females with mean age of 34.9+- 9.55 years. Low levels of serum HDL-c were found in 21 (45.7%) SCI patients (mean serum HDL-clevels: 0.97+-0.23). SCI patients were further categorized in two groups depending upon the status of regular physiotherapy. Statistically significant difference was found in mean serum HDL-c levels of 22 (47.82%) SCI patients undergoing regular physiotherapy as compared to 24 (52.18%) SCI patients who did not underwent physiotherapy (p<0.05). Conclusion: Patients with SCI have decreased levels of serum HDL-c, imparting an increased risk of cardiovascular disease (CVD) in these disabled persons. SCI individuals following regular physiotherapy, have better serum HDL-c levels as compared to bed-ridden SCI patients, suggesting the physical activity as an important factor to elevate the serum HDL-c in such patients. Knowledge of relative risk of CVD in persons with SCI is important for appropriate intervention alstrategies

  19. Crecimiento de Colossoma macropomum en estanques de tierra en dependencia de la densidad.

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    Jorge Günther

    2016-03-01

    Full Text Available Se analiza el crecimiento y la utilización de alimento del tambaquí, Colossoma macropomum, cultivado a densidades de 0,5, 1 y 2 peces/m2 en estanques de tierra de 60m2 con alimento balanceado con 35% proteína. No se encontraron diferencias estadísticas significativas con respecto a la densidad. Sin embargo, el crecimiento obtenido fue mucho menor que en otro ensayo realizado en las mismas condiciones y simultáneamente en un estanque de 3000 m2, por lo que se discute la hipótesis de que el crecimiento del tambaquí esté relacionado con el tamaño del estanque.

  20. The LDL-HDL profile determines the risk of atherosclerosis: a mathematical model.

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    Wenrui Hao

    Full Text Available Atherosclerosis, the leading death in the United State, is a disease in which a plaque builds up inside the arteries. As the plaque continues to grow, the shear force of the blood flow through the decreasing cross section of the lumen increases. This force may eventually cause rupture of the plaque, resulting in the formation of thrombus, and possibly heart attack. It has long been recognized that the formation of a plaque relates to the cholesterol concentration in the blood. For example, individuals with LDL above 190 mg/dL and HDL below 40 mg/dL are at high risk, while individuals with LDL below 100 mg/dL and HDL above 50 mg/dL are at no risk. In this paper, we developed a mathematical model of the formation of a plaque, which includes the following key variables: LDL and HDL, free radicals and oxidized LDL, MMP and TIMP, cytockines: MCP-1, IFN-γ, IL-12 and PDGF, and cells: macrophages, foam cells, T cells and smooth muscle cells. The model is given by a system of partial differential equations with in evolving plaque. Simulations of the model show how the combination of the concentrations of LDL and HDL in the blood determine whether a plaque will grow or disappear. More precisely, we create a map, showing the risk of plaque development for any pair of values (LDL,HDL.

  1. Beneficial effects of raloxifene and atorvastatin on serum lipids and HDL phospholipids levels of postmenopausal women.

    Science.gov (United States)

    Piperi, Christina; Kalofoutis, C; Skenderi, Katerina; Economidou, Olga; Kalofoutis, A

    2004-06-01

    Selective oestrogen receptor modulators (raloxifene) and statins (atorvastatin) have been shown to reduce the risk of cardiovascular disease associated with the postmenopausal status. Their beneficial effects may be mediated partly by favourable changes in serum lipids and particular on HDL phospholipid composition. In the present study, individual administration of either raloxifene (Group A) or atorvastatin (Group B) or both (Group C) was compared for a period of 3 months and their effects on total lipids and HDL phospholipids were evaluated. The combined treatment of raloxifene and atorvastatin resulted in profound changes in the majority of serum lipids, including a significant reduction in total cholesterol and triglycerides (P<0.001), a rise in total phospholipids (P<0.01) and a reduction in LDL-C and Apo B levels (P<0.001). Furthermore, Apo A-I was elevated (P<0.001) whereas total HDL phospholipids were significantly increased (P<0.05). Specifically, HDL phosphatidylcholine levels were markedly increased (P<0.001) and HDL lysophosphatidylcholine, sphingomyelin and phosphatidylinositol levels were reduced (P<0.05). A further attempt to evaluate each treatment group was performed and the significance of these results is discussed. PMID:15203583

  2. VITAMIN E SUPPLEMENT BLOCKS THE RESPONSE OF HDL TO LOVASTATIN THERAPY IN HYPERCHOLESTROLEMIC PATIENTS

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    S. M. Namayandeh

    2007-07-01

    Full Text Available HDL can prevent LDL-c oxidation. The low HDL-c State also may benefit clinically from supplemented antioxidant. This study was designed to evaluate the combination therapy of statin and vitamin E in hypercholesterolemic patients. The patients were randomized in a clinical trial aimed to avaluate the effect of vitamin E and/or statin.The life style of patients didn't alter during intervention. The subjects were randomized to two treatment groups A and B: (1 lovastatin 20mg daily at bedtime. (group A; (2 vitamin E 400 iu daily plus lovastatin 20 mg daily (group B. The lipid values of each patients at baseline and after 8 weeks of treatment were compared by paired t test. The mean baseline lipid levels for 60 subjects were as follows: plasma cholesterol, triglyceride, LDL-c and HDL-c 285 ± 68, 268 ± 121, 158 ± 32, 49 ± 11 mg/dl respectively. Serum lipid levels changes in group A (statin only and in group B (statin and vitamin E were statistically significant. In comparison of lipid profiles changes between two groups we observed that HDL-c changes in group B were significantly lower than in group A. Vitamin E supplement blocks the respons of HDL-c to lovastatin therapy in hypercholestrolemic patients.

  3. Comportamento de poedeiras criadas a diferentes densidades e tamanhos de grupo em ambiente enriquecido

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    Danilo Florentino Pereira

    2013-06-01

    Full Text Available O objetivo deste trabalho foi determinar diferenças comportamentais entre poedeiras criadas sob diferentes densidades e tamanhos de grupo, em condições de ambiente enriquecido. Foram utilizadas poedeiras Isa Brown com idade entre 30 e 32 semanas alojadas em galpões de escala reduzida e distorcida. As aves foram criadas durante 28 dias, em baias com cama de maravalha, poleiro e ninho. Foram avaliados dois tamanhos de grupos (6 e 12 aves e duas densidades de criação (774 e 1.440 cm² por ave, em arranjo fatorial com três repetições. Em amostras de vídeo de 15 min, foram registrados as frequências e os tempos de expressão dos comportamentos: arrumar penas, banho de areia, bater asas, beber água, bicar, coçar a cabeça, ciscar, comer, empoleirar, esticar perna, perseguir, sentar e visitar o ninho. Foram observados efeitos significativos dos tratamentos e da interação entre eles. O grupo de seis aves manifestou aumento da frequência de comportamentos que indicam maior frustração das aves, independentemente da densidade. O tamanho de grupo é o fator mais importante para o bem-estar das aves.

  4. Relación triglicéridos/colesterol-HDL elevada y resistencia a la insulina

    OpenAIRE

    Antonio González-Chávez; Luis Ernesto Simental-Mendía; Sandra Elizondo-Argueta

    2011-01-01

    Introducción: La enfermedad cardiovascular es la principal causa de muerte en el mundo y la resistencia a la insulina desempeña un papel fundamental para su desarrollo. Además, la resistencia a la insulina se ha asociado con hipertensión arterial sistémica y síndrome metabólico, al igual que la relación riglicéridos/colesterol-HDL (TGL/HDL). Objetivo: determinar si la relación TGL/HDL está asociada con resistencia a la insulina en una población aparentemente sana. Material y métodos: Estudio ...

  5. Very low levels of HDL cholesterol and atherosclerosis, a variable relationship – a review of LCAT deficiency

    OpenAIRE

    Savel, Julia; Lafitte, Marianne; Pucheu, Yann; Pradeau, Vincent; Tabarin, Antoine; Couffinhal, Thierry

    2012-01-01

    A number of epidemiological and clinical studies have demonstrated that plasma high-density lipoprotein (HDL) level is a strong inverse predictor of cardiovascular events. HDL is believed to retard the formation of atherosclerotic lesions by removing excess cholesterol from cells and preventing endothelial dysfunction. Lecithin cholesterol acyltransferase (LCAT) plays a central role in the formation and maturation of HDL, and in the intravascular stage of reverse cholesterol transport: a majo...

  6. Carriles para alta velocidad. Comportamiento en fatiga

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    Duart, J. M.

    2005-02-01

    -aire inducido. Los ensayos de fatiga de los carriles soldados se llevan a cabo por flexión en cuatro puntos en concordancia con la norma europea. El método Locati, descrito en esta nota, está basado en la Ley de Miner de daño acumulado y en las curvas de Wohler del material ensayado. Permite calcular, con precisión suficiente, las tensiones límites de fatiga al 50%. Así, los valores obtenidos, en ensayos a dos millones de ciclos, para carriles sin soldar (Sf = 353 MPa, carriles soldados con precalentamiento de oxipropano (Sf = 225 MPa y carriles soldados con precalentamiento de propano-aire inducido (Sf = 210 MPa son muy similares y aceptables a los estipulados por los métodos de determinación del límite de fatiga según norma europea. Debido a la comodidad, rapidez y bajo coste del método Locati resulta, en nuestra opinión, muy adecuado para el control de calidad de los procesos de soldadura aluminotérmica en vigor, de carriles de alta resistencia.

  7. Pre-clinical evaluation of rHDL encapsulated retinoids for the treatment of Neuroblastoma

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    Nirupama eSabnis

    2013-03-01

    Full Text Available Despite major advances in pediatric cancer research, there has been only modest progress in the survival of children with high risk neuroblastoma (HRNB. The long term survival rates of HRNB in the United States are still only 30-50%. Due to resistance that often develops during therapy, development of new effective strategies is essential to improve the survival and overcome the tendency of HRNB patients to relapse subsequent to initial treatment. Current chemotherapy regimens also have a serious limitation due to off target toxicity. In the present work, we evaluated the potential application of reconstituted high density lipoprotein (rHDL containing fenretinide (FR nanoparticles as a novel approach to current neuroblastoma therapeutics. The characterization and stability studies of rHDL-FR nanoparticles showed small size (<40nm and high encapsulation efficiency. The cytotoxicity studies of free FR vs. rHDL/ FR towards the neuroblastoma cell lines SK-N-SH and SMS-KCNR showed 2.8 and 2 fold lower IC50 values for the rHDL encapsulated FR vs. free FR. More importantly, the IC50 value for retinal pigment epithelial cells (ARPE-19, a recipient of off target toxicity during FR therapy, was over 40 times higher for the rHDL/ FR as compared to that of free FR. The overall improvement in in vitro selective therapeutic efficiency was thus about 100 fold upon encapsulation of the drug into the rHDL nanoparticles. These studies support the potential value of this novel drug delivery platform for treating pediatric cancers in general, and neuroblastoma in particular

  8. Fluorescence and atomic force microscopy to visualize the interaction of HDL particles with lipid membranes

    International Nuclear Information System (INIS)

    Full text: High density lipoprotein (HDL) plays a key role in cholesterol homeostasis: cholesterol-loaded HDL particles are transported from non-hepatic peripheral tissue to the liver, where they unload their cargo via receptor-mediated selective uptake. It is astonishing that – although blood levels of HDL are broadly used in diagnosis for the prognosis of developing cardiovascular disease – the cholesterol uptake mechanisms are still poorly understood. Particularly, it remains unclear how the amphipathic cholesterol crosses the aqueous phase between the HDL particle and the cell membrane. We applied state-of-the-art high-resolution and ultra-sensitive force and fluorescence microscopy techniques to image directly the interaction of HDL particles with the target membrane. Using highspeed atomic-force microscopy (AFM) we made a surprising discovery: when added to membranes, we observed HDL particles to integrate into the interleaflet core of the bilayer, generating 'nanoblisters' with a size below 10 nm. Amphipathic cargo was able to leave such blisters, whereas hydrophobic cargo such as cholesteryl-ester remained associated with the particles. Using a combined fluorescence and force microscopy system we could directly visualize the transfer of single cargo molecules into supported lipid bilayers. Particularly, we compared the transfer of the fluorescently labelled amphiphilic DiI and Bodipy-labelled cholesterol with the hydrophobic Bodipy-labelled cholesteryl- ester. Our experiments revealed that i) cargo transfer requires contact; ii) only amphiphilic cargo is transferred. Interestingly, membrane elasticity was found to be crucial for the fusion: only highly elastic (and thus cholesterol-poor) membranes facilitate particle fusion, whereas inelastic cholesterol-rich membranes prevented the fusion. Live cell experiments show that the plasma membrane itself regulates a cell’s cholesterol demand: high cholesterol levels act repulsive, low cholesterol levels

  9. Adrenal steroidogenesis disruption caused by HDL/cholesterol suppression in diethylstilbestrol-treated adult male rat.

    Science.gov (United States)

    Haeno, Satoko; Maeda, Naoyuki; Yamaguchi, Kousuke; Sato, Michiko; Uto, Aika; Yokota, Hiroshi

    2016-04-01

    The synthetic estrogen diethylstilbestrol is used to prevent miscarriages and as a therapeutic treatment for prostate cancer, but it has been reported to have adverse effects on endocrine homeostasis. However, the toxicity mechanism is poorly understood. Recently, we reported that diethylstilbestrol impairs adrenal steroidogenesis via cholesterol insufficiency in adult male rats. In the present study, we found that the adrenal cholesterol level was significantly reduced without of the decrease in other precursors in the adrenal steroidogenesis 24 h after a single dose of diethylstilbestrol (0.33 μg/g body mass). The serum HDL/cholesterol level was also reduced only 12 h after the diethylstilbestrol exposure. The level of Apo E, which is indispensable for HDL/cholesterol maturation, was decreased in both the HDL and VLDL/LDL fractions, whereas the level of Apo A1, which is an essential constituent of HDL, was not altered in the HDL fraction. Because the liver is a major source of Apo E and Apo A1, the secretion rates of these proteins were examined using a liver perfusion experiment. The secretion rate of Apo A1 from the liver was consistent between DES-treated and control rats, but that of Apo E was comparatively suppressed in the DES-treated rats. The disruption of adrenal steroidogenesis by diethylstilbestrol was caused by a decrease in serum HDL/cholesterol, which is the main source of adrenal steroidogenesis, due to the inhibition of Apo E secretion from the liver. PMID:26349937

  10. The usefulness of information on HDL-cholesterol: potential pitfalls of conventional assumptions

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    Furberg Curt D

    2001-05-01

    Full Text Available Abstract Treatment decisions related to disease prevention are often based on two conventional and related assumptions. First, an intervention-induced change in a surrogate marker (such as high-density lipoprotein [HDL]-cholesterol in the desired direction translates into health benefits (such as reduction in coronary events. Second, it is unimportant which interventions are used to alter surrogate markers, since an intervention benefit is independent of the means by which it is achieved. The scientific foundation for these assumptions has been questioned. In this commentary, the appropriateness of relying on low levels of HDL-cholesterol for treatment decisions is reviewed. The Veterans Affairs - HDL-Cholesterol Intervention Trial (VA-HIT investigators recently reported that only 23% of the gemfibrozil-induced relative reduction in risk of coronary events observed in the trial could be explained by changes in HDL-cholesterol between baseline and the 1-year visit. Thus, 77% of the health benefit to the participants was unexplained. Other possible explanations are that gemfibrozil has multiple mechanisms of action, disease manifestations are multifactorial, and laboratory measurements of HDL-cholesterol are imprecise. The wisdom of relying on levels and changes in surrogate markers such as HDL-cholesterol to make decisions about treatment choices should questioned. It seems better to rely on direct evidence of health benefits and to prescribe specific interventions that have been shown to reduce mortality and morbidity. Since extrapolations based on surrogate markers may not be in patients' best interest, the practice of medicine ought to be evidence-based.

  11. Metodologia para estudo do volume e densidade absoluta da placenta humana de termo

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    Del Nero Ulisses

    2002-01-01

    Full Text Available OBJETIVO: comparar duas metodologias para o cálculo do volume placentário em gestações normais de termo: a do princípio de Arquimedes e a do volume do cilindro, para estimar a densidade absoluta da placenta. Definir a metodologia mais adequada para o cálculo do volume e densidade placentários, que se relacione com o peso e classificação do recém-nascido. MÉTODOS: foram estudadas 50 placentas provenientes de gestações de termo sem complicações e calculados o volume e a densidade absoluta placentários: a pelo princípio de Arquimedes e b na suposição de que a placenta seria uma secção de cilindro com duas alturas diferentes do bolo placentário: com a altura média e com a altura da média aritmética do centro e extremidades. As densidades absolutas placentárias foram calculadas pelo quociente entre o peso ao ar da placenta e os diferentes volumes. RESULTADOS: a maioria das gestantes eram multíparas, idade média de 25,4 anos, volume placentário médio entre 547,8 e 610 cmsuperscript three e densidade média entre 0,94 e 1,14 g/cmsuperscript three, dependendo da metodologia empregada. CONCLUSÕES: a metodologia mais adequada para estimar o volume placentário no termo foi a do princípio de Arquimedes, pela melhor correlação com o peso dos recém-nascidos, o índice placentário e a classificação do peso dos recém-nascidos em relação à idade gestacional.

  12. Velodyne HDL-64E lidar for unmanned surface vehicle obstacle detection

    Science.gov (United States)

    Halterman, Ryan; Bruch, Michael

    2010-04-01

    The Velodyne HDL-64E is a 64 laser 3D (360×26.8 degree) scanning LIDAR. It was designed to fill perception needs of DARPA Urban Challenge vehicles. As such, it was principally intended for ground use. This paper presents the performance of the HDL-64E as it relates to the marine environment for unmanned surface vehicle (USV) obstacle detection and avoidance. We describe the sensor's capacity for discerning relevant objects at sea- both through subjective observations of the raw data and through a rudimentary automated obstacle detection algorithm. We also discuss some of the complications that have arisen with the sensor.

  13. CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake.

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    Heidi J Silver

    Full Text Available BACKGROUND: Success in further reducing the burden of cardiovascular disease (CVD is threatened by the increasing prevalence of obesity-related atherogenic dyslipidemia. HDL-cholesterol (HDL-C level is inversely correlated with CVD risk; each 1 mg/dl decrease in HDL-C is associated with a 6% reduction in risk. We previously showed that a common CNR1 haplotype, H3 (frequency 20%, is protective against the reduction in HDL-C that typically accompanies weight gain. In the present study, we extend that observation by reporting the effect of CNR1 haplotype on HDL-C response to modification of dietary fat intake in weight maintenance and weight loss. METHODS: Six haplotype tagging SNPs that cover the CNR1 gene locus were genotyped in 590 adults of varying body mass index (cohort 1 is 411 males with BMI 18.5-30.0 kg/m(2; cohort 2 is 71 females with BMI18.5-30.0 kg/m(2; and cohort 3 is 108 females with BMI 30-39.9 kg/m(2. Dietary intakes were modified so that fat intake in the "high fat" condition was 15-20% greater than in the "low fat" condition, and lipid profiles were compared between carriers versus noncarriers for each of the five commonly observed CNR1 haplotypes (H1-H5. RESULTS: In normal to overweight subjects on eucaloric diets, the H3 haplotype was significantly associated with short-term high fat diet induced changes in HDL-C level in females (carriers 5.9 mg/dl>noncarriers, p = 0.007. The H3 haplotype was also significantly associated with HDL-C level after 16 weeks on high fat calorie restricted diet in obese females (carriers 6.8 mg/dl>noncarriers, p = 0.009. CONCLUSION: Variability within the CNR1 gene locus contributes to gender-related differences in the HDL-cholesterol response to change in dietary fat intake. Functional characterization of this relationship in vitro may offer insights that potentially yield therapeutic guidance targeting dietary macronutrient composition, a direction much needed in the current epidemic of

  14. Microarray Expression Profiling Identifies Genes with Altered Expression in HDL-Deficient Mice

    OpenAIRE

    Callow, Matthew J.; Dudoit, Sandrine; Gong, Elaine L.; Speed, Terence P.; Rubin, Edward M.

    2000-01-01

    Based on the assumption that severe alterations in the expression of genes known to be involved in high-density lipoprotein (HDL) metabolism may affect the expression of other genes, we screened an array of >5000 mouse expressed sequence tags for altered gene expression in the livers of two lines of mice with dramatic decreases in HDL plasma concentrations. Labeled cDNA from livers of apolipoprotein AI (apoAI)-knockout mice, scavenger receptor BI (SR-BI) transgenic mice, and control mice were...

  15. Serum IF1 concentration is independently associated to HDL levels and to coronary heart disease: the GENES study[S

    OpenAIRE

    Genoux, Annelise; Ruidavets, Jean-Bernard; Ferrières, Jean; Combes, Guillaume; Lichtenstein, Laeticia; Pons, Véronique; Laffargue, Muriel; Taraszkiewicz, Dorota; Carrié, Didier; Elbaz, Meyer; Perret, Bertrand; Martinez, Laurent O.

    2013-01-01

    HDL is strongly inversely related to cardiovascular risk. Hepatic HDL uptake is controlled by ecto-F1-ATPase activity, and potentially inhibited by mitochondrial inhibitor factor 1 (IF1). We recently found that IF1 is present in serum and correlates with HDL-cholesterol (HDL-C). Here, we have evaluated the relationship between circulating IF1 and plasma lipoproteins, and we determined whether IF1 concentration is associated with the risk of coronary heart disease (CHD). Serum IF1 was measured...

  16. Rendimiento de plantas de tomate injertadas y efecto de la densidad de tallos en el sistema hidropónico Yield of tomato crop as a result of grafting and shoot density in hydroponic system

    Directory of Open Access Journals (Sweden)

    Roberta M.N. Peil

    2004-06-01

    Full Text Available El cultivo de tomate en primavera con baja densidad inicial de plantas y luego aumentar-se la densidad efectiva mediante el desarrollo de tallos laterales, cuando las integrales diarias de radiación son altas, parece ser una manera prometedora de incrementar el número de frutos m-2 y uniformizar el tamaño del fruto; y presenta la ventaja adicional de requerir-se un menor número de plantas para la superficie de cultivo. Por lo tanto, se ha llevado a cabo un ensayo cuyo objetivo ha sido evaluar los efectos de la densidad de tallos sobre el rendimiento y la uniformidad de los frutos de un cultivo de tomate injertado y no injertado. El cultivo se realizó de marzo a julio de 1998, en las condiciones de invernadero en Almería (sudeste español. La densidad inicial de plantación fue de 2,4 y 3,0 plantas m-2, en el caso de las plantas no injertadas, que presentaban un único tallo en el transplante; y 1,2 plantas m-2 en las plantas injertadas, que tenían dos tallos (2,4 tallos m-2. A partir del mes de abril, mediante el desarrollo de tallos laterales (cuando el tratamiento así lo exigía se pasó a tener las siguientes densidades: 2,4; 3,0 y 3,5 tallos m-2 (plantas injertadas y no injertadas; y 3,0 plantas no injertadas m-2 a un tallo durante todo el ciclo. Los resultados muestran que plantas de tomate injertadas y transplantadas a dos tallos tuvieron igual producción total, pero frutos de tamaño más uniforme, que plantas no injertadas transplantadas a un tallo y con doble densidad de plantas. Dentro del rango de 2,4 a 3,5 tallos m-2, una mayor densidad de tallos aumentó la producción precoz y dio un tamaño más uniforme de frutos, no afectando su peso promedio y la producción total. La adición de tallos laterales (3,0 tallos m-2 supuso una reducción de un 20% en el rendimiento total, pero vino acompañada por un ahorro de un 21% y de un 39% en el número de plantas no injertadas e injertadas, respectivamente, necesarias para la misma

  17. Densidade microvascular no carcinoma de língua Microvascular density in carcinoma of the tongue

    Directory of Open Access Journals (Sweden)

    ALI AMAR

    2002-09-01

    Full Text Available OBJETIVO: Avaliar a densidade microvascular no carcinoma epidermóide de língua oral, no sítio primário e em suas metástases linfáticas. MÉTODOS: Foram avaliados retrospectivamente 30 pacientes com carcinoma epidermóide restrito à língua oral, submetidos a tratamento cirúrgico incluindo esvaziamento cervical. A densidade microvascular foi avaliada por imunohistoquímica empregando o anticorpo anti-CD34 e quantificada à microscopia óptica, no tumor primário e em suas metástases linfonodais. Foi avaliada a relação entre a densidade microvascular, as variáveis clínicas e histológicas e o prognóstico. RESULTADOS: A densidade microvascular apresentou mediana de 15,4 vasos/campo (5,5 a 25,3 nos tumores primários e 16,4 vasos/campo (12 a 32,2 nas metástases linfáticas. Foi observada uma relação inversa entre a densidade microvascular no tumor primário e na respectiva metástase linfática (r= -0,68 e p=0,04. A densidade microvascular não apresentou relação com outras variáveis histológicas ou com o prognóstico. CONCLUSÃO: Há Uma relação inversa entre a densidade microvascular no sítio primário e na metástase linfonodal, sugerindo um controle regional ou sistêmico da angiogênese.BACKGROUND. Assessment of microvascular density in squamous cell carcinoma of the oral tongue (primary lesion and metastasis. METHODS. Immunohistochemical analysis by anti CD-34 of neoangiogenesis density and its relation with clinical and histological data concerning the prognosis. After optic microscopy amplification, the relation between microvascular density, clinico-histological data and prognosis, was established. RESULTS. The microvascular density presented 15.4 vessels/field (5.5 to 25.3 in primary tumors and 16.4 vessels/field (12 to 32.2 in lymph node metastases. It was observed an inverse relation between microvascular density in primary lesions and their lymph node metastasis (r= -0.68 and p=0,04. CONCLUSIONS. No evidence was

  18. Impact of estimated HDL particle size via the ratio of HDL-C and apoprotein A-I on short-term prognosis of diabetic patients with stable coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    Li-Feng HONG; Bo YANG; Song-Hui LUO; Jian-Jun LI

    2014-01-01

    BackgroundRevascularization and statin therapy are routinely used in the management of stable coronary artery disease. However, it is unclear whether the estimated high-density lipoprotein (HDL) particle size (eHDL-S), the ratio of HDL cholesterol (HDL-C) to apoprotein A-I (apoA-I), is associated with the clinical outcomes of diabetic patients with stablecoronary artery disease (CAD).MethodsWe per-formed a prospective cohort study of 328 patients diagnosed with stable CAD by coronary angiography. Patients were followed up for a mean duration of 12 months. The patients were divided into three groups by the tertiles of eHDL-S: low eHDL-S ( 0.79,n= 99). The associations between the baseline eHDL-S and short-term out-comes were evaluated using the Kaplan-Meier method and Cox proportional regression.Results The low eHDL-S group had higher trig-lyceride, hemoglobin A1c, uric acid, and leukocyte count than the other groups. During the follow-up period, 47/328 patients experienced a pre-specified outcome. According to the Kaplan-Meier analysis, the incidence of pre-specified outcomes was lower in the high eHDL-S group (P = 0.04). However, eHDL-S was not independently associated with adverse outcomes in Cox proportional hazards regression (haz-ard ratio (HR): 0.23, 95% confidence interval (95% CI): 0.01-11.24,P = 0.493).ConclusionAlthough the eHDL-S was associated with inflammatory biomarkers, it was not independently associated with the short-term prognosis of diabetic patients with stable CAD in the era of revascularization and potent statin therapy.

  19. Parâmetros sangüíneos de pacu Piaractus mesopotamicus (Holmberg, 1887 alimentados com dietas suplementadas com cromo trivalente em duas densidades de estocagem = Hematological parameters of pacu Piaractus mesopotamicus (Holmberg, 1887 fed diets supplemented with trivalent chromium in two stocking densities

    Directory of Open Access Journals (Sweden)

    Rodrigo Yudi Fujimoto

    2007-10-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos da suplementação com cromo trivalente (0, 6, 12 e 18 mg kg-1 de ração sobre as variáveis hematológicas de Piaractus mesopotamicus, mantidos em duas densidades de estocagem (4 e 20 kg m-3. Os mantidos na maior densidade e alimentados com dietas suplementadas com 0 e 6 mg de cromo kg-1apresentaram redução do número de linfócitos circulantes, sugerindo má adaptação a essa condição de alta densidade. Nas dietas suplementadas com 12 e 18 mg kg-1, tal efeito não foi observado, porém verificou-se aumento do número de trombócitos no tratamento com 12 mg de cromo kg-1. A inexistência de diferença significativa entre os tratamentos, aos 30 dias, sugere a adaptação dos peixes ao tipo de alimento e à situação de alta densidade. Portanto, nas condições deste ensaio, a suplementação com 12 e 18 mg de cromo kg-1 é interessante como estratégia alimentar durante 15 dias.This work evaluated the effects of chromium supplementation on thehematological parameters of Piaractus mesopotamicus Holmberg, 1887 maintained in two stocking densities. Fish were fed diets supplemented with 0, 6, 12 and 18 mg trivalent chromium kg-1 dry ration and maintained at 4 and 20 kg m-3. The fish under high stockingdensity and fed diets supplemented with 0 and 6 mg kg-1 showed reduction in the number lymphocytes, which suggests non-adaptation to this condition of high density. This was not observed in fish fed diets supplemented with 12 and 18 mg chromium kg-1, but an increasein the number of thrombocytes was evident. The lack of difference between treatments after 30 days may suggest a possible adaptation of fish to the situation. It can be added that supplementation with 12 and 18 mg chromium kg-1 is an interesting feeding strategy for aperiod of 15 days.

  20. High intensity Discharge lighting; Alumbrado de alta intensidad de descarga

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza E, Ernesto J. [Manufacturera de Reactores, S. A., Mexico, D. F. (Mexico)

    1993-12-31

    This paper gets into contact with some fundamentals in the operation of high discharge intensity lamps. There are useful definitions, as well as the study of the operation of high pressure sodium lamps and of metallic additives operating at less than nominal power. [Espanol] Este trabajo pone al lector en contacto con algunos fundamentos de la operacion de las lamparas de alta intensidad de descarga (HID). Se encuentra con definiciones utiles, asi como el estudio de la operacion de las lamparas de sodio en alta presion y de aditivos metalicos operando a una potencia menor que la nominal.

  1. Enriquecimiento curricular para el alumnado con altas capacidades en primaria

    OpenAIRE

    Boldú Caballero, Tomás

    2013-01-01

    La finalidad de este documento es proporcionar al lector, primero, una rápida ojeada a la trayectoria histórica de la atención a las NEE (más concretamente de las altas capacidades); segundo, una conceptualización de las altas capacidades y sus necesidades educativas específicas tomando como punto de referencia algunos de lo más eminentes autores y corrientes psicopedagógicas actuales o del pasado reciente; y por último, facilitar ejemplos prácticos desde la perspectiva del doc...

  2. Cócs. Hallmark of the Terra Alta

    OpenAIRE

    Maria Del Loreto Meix

    2004-01-01

    This article looks at the traditional cake making in the Terra Alta (Catalonien) area linked to festivities, and in particular the pastries usually made. In this area the pastries are known as cócs, a word common to Terra Alta and the neighbouring districts of Ribera d'Ebre and the Priorat. Locally produced mistelle, sweet or rancid wine is served with the pastries. Nowadays, the bakeries and cake makers in the area's towns and villages also produce traditionally crafted products, tha...

  3. A tomografia computadorizada de alta resolução na avaliação da toxicidade pulmonar por amiodarona High-resolution computed tomography of amiodarone pulmonary toxicity

    Directory of Open Access Journals (Sweden)

    Daniela Peixoto Consídera

    2006-04-01

    Full Text Available OBJETIVO: Avaliar as principais alterações identificadas na tomografia computadorizada de alta resolução do tórax em pacientes com toxicidade pulmonar pela amiodarona. MATERIAIS E MÉTODOS: Foram avaliadas dez tomografias computadorizadas de alta resolução de tórax de pacientes com pneumonite pela amiodarona, seis desses pacientes do sexo masculino e quatro do sexo feminino, com idade média de 73,5 anos. RESULTADOS: Os achados tomográficos mais relevantes foram opacidades lineares ou reticulares em seis casos (60%, pequenos nódulos com densidade elevada em seis casos (60%, consolidações densas em três casos (30% e aumento da densidade do parênquima hepático em cinco de oito casos em que havia estudo tomográfico do abdome superior (62,5%. CONCLUSÃO: A tomografia computadorizada de alta resolução é um exame importante na avaliação de pacientes com toxicidade pulmonar pela amiodarona, devendo ser realizada sempre que houver suspeita deste diagnóstico. O achado de espessamento de septos interlobulares associado a lesões com aumento de densidade é altamente sugestivo deste diagnóstico.OBJECTIVE: To evaluate the main findings of chest high-resolution computed tomography in patients with amiodarone pulmonary toxicity. MATERIALS AND METHODS: Ten patients - six male and four female, average age of 73.5 years - with amiodarone-induced pneumonitis have undergone chest high-resolution computed tomography. RESULTS: The most relevant tomographic findings were linear or reticular opacities in six cases (60%, small high density nodules in six cases (60%, dense consolidations in three cases (30% and increased density in the hepatic parenchyma in five of eight cases in which there was a superior abdomen CT scan (62.5%. CONCLUSION: The high-resolution computed tomography is a valuable non-invasive test for evaluating patients with amiodarone pulmonary toxicity and should always be performed when one suspects of the presence of this

  4. Dieta vegetariana e níveis de colesterol e triglicérides Vegetarian diet and cholesterol and triglycerides levels

    OpenAIRE

    Simone Grigoletto De Biase; Sabrina Francine Carrocha Fernandes; Reinaldo José Gianini; João Luiz Garcia Duarte

    2007-01-01

    OBJETIVO: Comparar os valores de triglicérides (TG), colesterol total (CT), lipoproteína de baixa densidade (LDL) e lipoproteína de alta densidade (HDL) entre indivíduos vegetarianos e onívoros. MÉTODOS: Foram coletadas amostras sangüíneas de 76 indivíduos, de ambos os sexos, que foram separados em quatro grupos de dieta: onívoro, ovolacto, lacto e vegetariano restrito (ou "vegan"). Foram dosados: CT, LDL, HDL e TG. RESULTADOS: Para as taxas de CT, LDL e TG, observa-se diferença significante ...

  5. Sex differences in HDL ApoC-III in American Indian youth

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    Blackett Piers R

    2012-08-01

    Full Text Available Abstract Background Since American Indians are predisposed to type 2 diabetes (DM2 and associated cardiovascular risk, Cherokee boys and girls (n = 917 were studied to determine whether BMI Z (body mass index Z score is associated with the apoC-III (apolipoprotein C-III content of HDL (high density lipoprotein, a previously reported predictor of DM2. Methods An ad hoc cross-sectional analysis was conducted on a previously studied cohort. Participants were grouped by gender-specific age groups (5 to 9, 10 to 14 and 15 to 19 years. ApoA-I (apolipoprotein A-I and HDL apoC-III were assayed by electroimmunoassay. ApoC-III was measured in whole plasma, and in HDL to determine the molar proportion to apoA-I. General linear models were used to assess association. Results The HDL apoC-III to apoA-I molar ratio increased by BMI Z quartile in girls aged 10–14 years (p  Conclusions ApoC-III showed an obesity-related increase relative to apoA-I during adolescence beginning in girls aged 10 to 14 years and in boys aged 15 to 19 years. The earlier changes in girls may alter HDL’s protective properties on the β-cell and contribute to their increased risk for DM2.

  6. Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci.

    Science.gov (United States)

    Wang, Xiaosong; Le Roy, Isabelle; Nicodeme, Edwige; Li, Renhua; Wagner, Richard; Petros, Christina; Churchill, Gary A; Harris, Stephen; Darvasi, Ariel; Kirilovsky, Jorge; Roubertoux, Pierre L; Paigen, Beverly

    2003-07-01

    Mapping quantitative trait loci (QTLs) with high resolution facilitates identification and positional cloning of the underlying genes. The novel approach of advanced intercross lines (AILs) generates many more recombination events and thus can potentially narrow QTLs significantly more than do conventional backcrosses and F2 intercrosses. In this study, we carried out QTL analyses in (C57BL/6J x NZB/BlNJ) x C57BL/6J backcross progeny fed either chow or an atherogenic diet to detect QTLs that regulate high-density lipoprotein cholesterol (HDL)concentrations, and in (C57BL/6J x NZB/BlNJ) F11 AIL progeny to confirm and narrow those QTLs. QTLs for HDL concentrations were found on chromosomes 1, 5, and 16. AIL not only narrowed the QTLs significantly more than did a conventional backcross but also resolved a chromosome 5 QTL identified in the backcross into two QTLs, the peaks of both being outside the backcross QTL region. We tested 27 candidate genes and found significant mRNA expression differences for 12 (Nr1i3, Apoa2, Sap, Tgfb2, Fgfbp1, Prom, Ppargc1, Tcf1, Ncor2, Srb1, App, and Ifnar). Some of these underlay the same QTL, indicating that expression differences are common and not sufficient to identify QTL genes. All the major HDL QTLs in our study had homologous counterparts in humans, implying that their underlying genes regulate HDL in humans. PMID:12805272

  7. Competition in a rice - cowpea intercrop as affected by nitrogen fertilizer and plant population Competição em uma cultura consorciada de arroz-guandu em função do fertilizante nitrogenado e da densidade populacional de plantas

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    Frank Oke Oroka

    2007-12-01

    Full Text Available The increased productivity or yield advantage provided by intercropping is attributed to a better use of resources by crops grown in mixtures, as compared to the same species grown in sole stands. In an intercropping system with upland rice and cowpea, the intra and inter-competition was quantified, as affected by plant population density and rate of nitrogen. Reductions in number of panicles per rice plant and number of grains per panicle were obtained with high density in both sole and mixture rice populations. Increasing nitrogen rate did not affect yield and yield components in both populations, but number and weight of pods per plant of cowpea in sole stands increased. Land equivalent ratios exceeding unity were obtained, indicating an improved resource use by the crop mixture. Relative crowding coefficient and aggressivity indices showed cowpea to be the dominant crop, with rice being dominated. Nitrogen utilization efficiency was high with intercrops, but was generally poor in stands of high population density.O aumento em produtividade devido a plantios consorciados é atribuído ao melhor uso dos recursos presentes pelas plantas em desenvolvimento conjunto, em comparação às mesmas espécies crescendo em dosséis separados. Em um sistema consorciado de arroz e guandu quantificou-se as inter- e intra competições em relação à densidade populacional e taxa de aplicação de nitrogênio. Reduções significativas do número de panículas por planta de arroz e número de grãos por panícula foram observados para alta densidade, tanto para culturas solteira de arroz como em populações mistas. O aumento das doses de nitrogênio não afetou a produção e os componentes de produção em ambos os sistemas, ao passo que o número e peso de vagens por planta do guandu aumentaram em culturas solteiras. Foram obtidas razões de área equivalente maiores que a unidade, mostrando melhoria no uso da terra nas culturas mistas. O coeficiente

  8. An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration

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    Xun Chen, Charlotte Burton, Xuelei Song, Lesley Mcnamara, Annunziata Langella, Simona Cianetti, Ching H. Chang, Jun Wang

    2009-01-01

    Full Text Available Lecithin cholesterol acyltransferase (LCAT plays a key role in the reverse cholesterol transport (RCT process by converting cholesterol to cholesteryl ester to form mature HDL particles, which in turn deliver cholesterol back to the liver for excretion and catabolism. HDL levels in human plasma are negatively correlated with cardiovascular risk and HDL functions are believed to be more important in atheroprotection. This study investigates whether and how D-4F, an apolipoprotein A-I (apoA-I mimetic peptide, influences LCAT activity in the completion of the RCT process. We demonstrated that the apparent rate constant value of the LCAT enzyme reaction gives a measure of LCAT activity and determined the effects of free metals and a reducing agent on LCAT activity, showing an inhibition hierarchy of Zn2+>Mg2+>Ca2+ and no inhibition with β-mercaptoethanol up to 10 mM. We reconstituted nano-disc particles using apoA-I or D-4F with phospholipids. These particles elicited good activity in vitro in the stimulation of cholesterol efflux from macrophages through the ATP-binding cassette transporter A1 (ABCA1. With these particles we studied the LCAT activity and demonstrated that D-4F did not activate LCAT in vitro. Furthermore, we have done in vivo experiments with apoE-null mice and demonstrated that D-4F (20 mg/kg body weight, once daily subcutaneously increased LCAT activity and HDL level as well as apoA-I concentration at 72 hours post initial dosing. Finally, we have established a correlation between HDL concentration and LCAT activity in the D-4F treated mice.

  9. Evaluation of LDL-Cholesterol / HDL-Cholesterol Ratio as Predictor of Dyslipidemia in Subclinical Hypothyroidism

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    Smita S. Kottagi

    2014-01-01

    Full Text Available Background: Subclinical hypothyroidism is defined as a serum TSH concentration above the upper limit of the reference range when serum T3 and T4 concentrations are within reference ranges. Subclinical thyroid disease is a laboratory diagnosis. Patients with subclinical disease have few or no definitive clinical signs or symptoms of thyroid dysfunction. It has been associated with higher levels of some cardiovascular risk factors. Despite some conflicting results, many studies have found that subjects with subclinical hypothyroidism have total cholesterol and low density lipoprotein cholesterol levels higher than euthyroid subjects. The association between subclinical hypothyroidism and dyslipidemia is well known. Aims and Objectives: This study is an attempt to find the importance of Low Density Lipoprotein – Cholesterol / Higher Density Lipoprotein - Cholesterol (LDL-C/HDL-C ratio rather than measurement of individual lipid profile parameters in bringing to light the dyslipidemic state associated with subclinical hypothyroidism. Materials and Methods: We studied 30 subclinical hypothyroid cases with age above 35 yrs and 30 age matched euthyroid controls. Serum T3, T4, TSH were estimated by ELISA method, serum total cholesterol, HDL Cholesterol by enzymatic CHOD-PAP method, and LDL cholesterol using Friedewald formula. Results: We found the significant increase in the serum levels of TSH (p < 0.001, Total cholesterol (p<0.001, LDL cholesterol (p<0.001, and LDL-C/HDL-C (p<0.001, Systolic blood pressure and diastolic blood pressure (p<0.001. There was no significant change in the levels of serum T3, T4, HDL- cholesterol. Conclusion: Increased levels of total cholesterol, LDL cholesterol and increased LDL-C/HDL-C ratio are seen in patients with subclinical hypothyroidism. LDL-C/HDLC ratio is a better indicator for dyslipidemia in subclinical hypothyroid cases.

  10. Higher HDL cholesterol is associated with better cognitive function: the Maine-Syracuse study.

    Science.gov (United States)

    Crichton, Georgina E; Elias, Merrill F; Davey, Adam; Sullivan, Kevin J; Robbins, Michael A

    2014-11-01

    Few studies have examined associations between different subcategories of cholesterol and cognitive function. We examined relationships between total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride levels and cognitive performance in the Maine-Syracuse Longitudinal Study, a community-based study of cardiovascular risk factors. Cross-sectional analyses were undertaken on data from 540 participants, aged 60 to 98 years, free of dementia and stroke. TC, HDL, LDL, and triglyceride levels were obtained. Cognitive function was assessed using a thorough neuropsychological test battery, including domains of cognitive function indexed by multiple cognitive tests. The cognitive outcomes studied were as follows: Visual-Spatial Memory and Organization, Verbal and Working Memory, Scanning and Tracking, Abstract Reasoning, a Global Composite score, and the Mini-Mental State Examination (MMSE). Significant positive associations were observed between HDL-cholesterol and the Global Composite score, Working Memory, and the MMSE after adjustment for demographic and cardiovascular risk factors. Participants with desirable levels of HDL (≥60 mg/dL) had the highest scores on all cognitive outcomes. There were no significant associations observed between TC, LDL, or triglyceride concentrations and cognition. In older individuals, HDL-cholesterol was related to a composite of Working Memory tests and for general measures of cognitive ability when adjusted for cardiovascular variables. We speculate that persons over 60 are survivors and thus less likely to show cognitive deficit in relation to TC, LDL-cholesterol, and triglycerides. Longitudinal studies are needed to examine relations between specific cognitive abilities and the different subcategories of cholesterol. PMID:25382185

  11. Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels

    Directory of Open Access Journals (Sweden)

    Hinds David A

    2004-11-01

    Full Text Available Abstract Association studies are used to identify genetic determinants of complex human traits of medical interest. With the large number of validated single nucleotide polymorphisms (SNPs currently available, two limiting factors in association studies are genotyping capability and costs. Pooled DNA genotyping has been proposed as an efficient means of screening SNPs for allele frequency differences in case-control studies and for prioritising them for subsequent individual genotyping analysis. Here, we apply quantitative pooled genotyping followed by individual genotyping and replication to identify associations with human serum high-density lipoprotein (HDL cholesterol levels. The DNA from individuals with low and high HDL cholesterol levels was pooled separately, each pool was amplified by polymerase chain reaction in triplicate and each amplified product was separately hybridised to a high-density oligonucleotide array. Allele frequency differences between case and control groups with low and high HDL cholesterol levels were estimated for 7,283 SNPs distributed across 71 candidate gene regions spanning a total of 17.1 megabases. A novel method was developed to take advantage of independently derived haplotype map information to improve the pooled estimates of allele frequency differences. A subset of SNPs with the largest estimated allele frequency differences between low and high HDL cholesterol groups was chosen for individual genotyping in the study population, as well as in a separate replication population. Four SNPs in a single haplotype block within the cholesteryl ester transfer protein (CETP gene interval were significantly associated with HDL cholesterol levels in both populations. Our study is among the first to demonstrate the application of pooled genotyping followed by confirmation with individual genotyping to identify genetic determinants of a complex trait.

  12. Hepatic and extrahepatic uptake of HDL-derived plasma cholesterol in exercised and sedentary rats

    International Nuclear Information System (INIS)

    The present investigation was designed to study high density lipoprotein (HDL)-derived plasma cholesterol (C) turnover in hepatic and extrahepatic tissues of sedentary (S) and exercised (E) rats. 4-week-old Long Evans rats were exercised for 1 hr, 6 days weekly, for a period of 38 weeks, on a motor-driven treadmill at 0.8 mph at a 12% grade. Animals were injected with HDL that was labelled in vitro with 3H-cholesteryl ester. Serial blood samples and tissues were collected. HDL-C concentration was lower in E vs S rats (23.0 +/- 1.2 and 26.6 +/- 1.9 mg/dl, p < 0.01). While total plasma C was not different, liver C was higher in S vs E rats (8.2 +/- 0.8 and 7.2 +/- 0.5 mg/g). Adrenal C was higher in E vs S rats (29.5 +/- 2.3 and 20.7 +/- 2.3 mg/g, p < 0.01). Multicompartmental analysis of plasma and tissue tracer response led to development of an 8-component model (5 physiological; 3 nonphysiological) that depicted HDL-derived plasma C turnover. Plasma fraction of tracer declined more rapidly in E vs S rats. E rats cleared nonphysiological tracer more rapidly than S rats, but delayed release of tracer into the plasma longer. Fractional rate of tracer uptake into adrenals, liver, testes, and carcass was greater in E rats. There was a greater fractional turnover rate of tracer in adrenals and liver in S vs E rats. Hence HDL-derived plasma C turnover is altered with vigorous exercise

  13. Densidade de plantio, crescimento, produtividade e qualidade das frutas de morangueiro "Camino Real" em hidroponia

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    Isabelita Pereira Portela

    2012-09-01

    Full Text Available Com o objetivo de determinar o efeito da densidade de plantio sobre o crescimento da planta, a produtividade e características químicas relacionadas à qualidade organoléptica das frutas da cultivar de morangueiro Camino Real em sistema hidropônico do tipo NFT, diferentes densidades de plantio foram avaliadas: 15,0; 12,5; 10,7 e 9,3 plantas m-2, correspondentes ao espaçamento entre plantas de 0,25; 0,30; 0,35 e 0,40 m, sendo fixado o espaçamento entre linhas de 0,18 m. O sistema NFT foi constituído por bancadas de telhas de fibrocimento de 1,10 x 2,44 m, considerando-se cada ondulação côncava da telha como um canal de cultivo. O transplante foi realizado em 26-04-2010, encerrando-se o experimento em 05-01-2011. Avaliaram-se a matéria fresca e seca de folhas, coroa, raízes e frutas, a área foliar, o número de frutas e o peso médio das frutas. Amostras das frutas foram analisadas em relação ao teor de sólidos solúveis totais (SST e à acidez total titulável (ATT. Com base nos resultados obtidos, conclui-se que o crescimento e a produtividade individual das plantas da cultivar de morangueiro Camino Real não são afetados pela elevação da densidade de plantio, no intervalo entre 9,3 e 15,0 plantas m-2. O crescimento e a produtividade por unidade de área, bem como a concentração de sólidos solúveis totais e a relação SST/ATT apresentam resposta linear ao incremento da densidade de plantio. Sugere-se a adoção da densidade de 12,5 plantas m-2, que proporcionaria rendimento mais elevado (2,79 kg m-2 de frutas com adequadas características organolépticas e redução no número de mudas necessárias, em relação à densidade de 15,0 plantas m-2. Existe a necessidade de desenvolver estudos adicionais com a cultivar Camino Real, a fim de promover adaptações no sistema e verificar a viabilidade econômica de seu cultivo em hidroponia.

  14. Características del alumnado con altas capcidades

    OpenAIRE

    Grau Rubio, Claudia

    2012-01-01

    Se describen las características del alumnado con altas capacidades, la terminología más usual y la clasificación. Asimismo, se expone la teoría de la disincronía y los mitos relacionados con este alumnado.

  15. El niño, oscilación del sur (ENOS, con relación a la transmisión de malaria, densidad y paridad de An. albimanus y An. darlingi (diptera: culicidae en dos regiones de Colombia

    Directory of Open Access Journals (Sweden)

    Ricardo Mantilla

    2000-02-01

    Full Text Available

    Una fuerte asociación ha sido registrada entre los incrementos en la transmisiónas forzadas por el fenómeno El Niño. Entre las posibles explicaciones para esta asociación está el efecto del clima sobre la dinámica de población de vectores, por ejemplo, generando cambios en la densidad y en las tasas de sobrevivencia de la población, y en la cantidad y calidad de sitios de reproducción, como también a través de cambios en el período de incubación extrínseco del parásito dentro del vector. Con el propósito de evaluar la influencia de ENOS sobre la densidad y paridad de Anopheles albimanus y An. darlingi, y su relación con la transmisión de malaria, se realizó un estudio longitudinal en Chocó y Casanare. En cada área se seleccionaron dos localidades y se realizaron muestreos entomológicos durante una semana cada mes, desde finales de 1997 hasta 1999. Este período cubrió los eventos El Niño 1997 -1998 y La Niña 1998 - 2000. En las localidades de Chocó se observó un importante incremento en el número de casos de malaria durante el evento ENOS, asociado con la temperatura. No se observó una asociación estadísticamente significativa entre los casos de malaria y la precipitación o la humedad relativa. La relación entre el incremento de malaria durante El Niño y las variables entomológicas no fue evidente. La densidad y paridad de ambas especies de vectores fluctuaron durante el período de estudio y no se encontró una asociación significativa entre estas variables y los factores climáticos como la temperatura. La precipitación y la humedad relativa. La densidad de larvas de An. albimanus fluctuó durante el estudio, y mostró altas densidades alrededor de julio - agosto. No se observó asociación entre la densidad de larvas con la densidad de adultos o las variables climáticas. El efecto del evento ENOS sobre las poblaciones de vectores

  16. Variabilidade espacial da densidade e da porosidade de um Latossolo Vermelho Eutroférrico sob semeadura direta por vinte anos Spatial variability of soil bulk density and soil porosity on Rhodic Eutrudox under no tillage for twenty years

    Directory of Open Access Journals (Sweden)

    Glécio Machado Siqueira

    2009-09-01

    Full Text Available Todas as práticas de manejo causam impacto sobre os atributos do solo que se traduzem em influência sobre o desenvolvimento das culturas. Sabe-se que no sistema de semeadura direta ocorre compactação do solo na camada superficial, com tendência a progredir com o tempo de cultivo. Este trabalho teve como objetivo avaliar a variabilidade espacial da densidade e da porosidade de um Latossolo Vermelho eutroférrico sob semeadura direta por vinte anos. O trabalho foi desenvolvido em Campinas (SP considerando o período entre 1985 e 2005. Os atributos analisados neste estudo foram: argila (g kg-1, silte (g kg-1, areia (g kg-1, densidade (kg dm-3, porosidade total (%, macroporosidade (% e microporosidade (%. Ferramentas de geoestatística foram utilizadas para análise dos dados e construção de mapas de variabilidade espacial da densidade e da porosidade do solo. A amostragem realizada em 1985 não foi capaz de detectar a variabilidade espacial da densidade e porosidade do solo. Nos atributos físicos amostrados em 2005, observou-se alta razão de dependência espacial. Nos mapas de variabilidade espacial não se constatou relação clara entre a textura, a densidade e a porosidade do solo. Na área após vinte anos de manejo com semeadura direta não havia problemas com compactação. O manejo do solo com semeadura direta influenciou favoravelmente a variabilidade espacial dos atributos amostrados em 2005.Soil management practices affect its attributes which will further affect crop development. It is generally known and accepted that soil surface compaction occurs in no tillage system and that this compaction tends to increase with time. However, most of the research do not evaluate adequately soil physical properties behavior as affected by time of management. The objective of this work was to evaluate spatial variability of soil bulk density and soil porosity on a Rhodic Eutrudox under no tillage with annual crops for twenty years. The work

  17. Densidades de plantio na produtividade e qualidade de frutos de melancia

    OpenAIRE

    Anamaria RP Ramos; Rita de Cássia de S. Dias; Carlos Alberto Aragão

    2009-01-01

    O experimento foi conduzido na Embrapa Semi-Árido em Petrolina-PE, de setembro a dezembro de 2007, para avaliar o desempenho agronômico e a qualidade dos frutos de melancia cultivadas sob diferentes densidades de plantio. Foram avaliados três espaçamentos combinados com seis cultivares de melancia, sendo duas diplóides de polpa amarela (BRS Soleil e BRS Kuarah), duas triplóides (Híbrido Triplóide CPATSA e Extasy Seedless) e duas cultivares comerciais, também diploídes e de fruto pequeno (Smil...

  18. Chorros laminares de gas con valores muy dispares de las densidades del chorro y del ambiente

    OpenAIRE

    Sánchez Sanz, Mario

    2007-01-01

    En esta tesis se analiza la estructura de chorros laminares cuya densidad es muy diferente a la del ambiente en el que descargan debido a que, bien su temperatura o bien su peso molecular, son muy distintos. El estudio se centra en valores del número de Reynolds Re moderadamente grandes en los que el chorro continua siendo esbelto y estable. En este régimen, los términos correspondientes a la difusión axial y las variaciones transversales de presión pueden despreciarse en prime...

  19. Resultados da conjuntivodacriocistorrinostomia com implante de prótese lacrimal de polietileno de baixa densidade

    OpenAIRE

    Bison Simone; Soccol Ovídio; Scarpi Marinho Jorge

    2002-01-01

    Objetivos: Estabelecer quais são as complicações pós-operatórias da conjuntivodacriocistorrinostomia (CDCR) com implante de prótese lacrimal de polietileno de baixa densidade e relacionar a etiologia da obstrução e o aparecimento destas complicações e, conseqüentemente, o sucesso pós-operatório. Métodos: Foram analisadas 35 vias lacrimais submetidas a conjuntivodacriocistorrinostomia com implante de prótese lacrimal de polietileno. Com a finalidade de estudar as possíveis relações entre as va...

  20. Efeito da densidade de estocagem no desenvolvimento inicial do acará-bandeira (Pterophyllum scalare)

    OpenAIRE

    L.P. Gonçalves Júnior; S L Pereira; M.D. Matielo; P.P. Mendonça

    2013-01-01

    Avaliou-se a influência da densidade de estocagem no desenvolvimento inicial do acará-bandeira (Pterophyllum scalare). O desempenho produtivo foi avaliado pelo ganho de peso (GP), ganho de comprimento total (GCT), ganho de comprimento padrão (GCP), ganho de altura (GA), taxa de crescimento específico (TCE), taxa de desenvolvimento específico (TDE) e sobrevivência (S). Para realização do experimento, foram utilizadas 300 pós-larvas de peso médio inicial de 0,0012g, comprimento total médio de 4...

  1. Densidade e diversidade fenotípica de bactérias diazotróficas não simbióticas em solos da Reserva Biológica Serra dos Toledos, Itajubá (MG

    Directory of Open Access Journals (Sweden)

    Talita Filomena Silva

    2011-04-01

    Full Text Available Bactérias diazotróficas não simbióticas (BDNS atuam no desenvolvimento das plantas por meio da fixação biológica de nitrogênio e também pela produção e liberação de substâncias reguladoras do crescimento vegetal. Este estudo objetivou avaliar a densidade e diversidade fenotípica desse grupo de bactérias em fragmentos de solo da Reserva Biológica Serra dos Toledos e entorno, em Itajubá/MG. Essa reserva localiza-se na Área de Proteção Ambiental da Mantiqueira, constituindo-se em uma importante área de recarga e de abrigo à flora e fauna endêmicas. Amostras de solo superficial foram coletadas em áreas com diferentes declividades na reserva, em épocas representativas das estações de inverno (setembro/2006 e verão (abril/2007. A densidade, avaliada pelo número mais provável, utilizando os meios de cultura NFb, JNFb e Fam, para Azospirillum spp., Herbaspirillum spp. e A. amazonense, respectivamente, variou de 0,12 a 75,60 (NMP x 10(5 bactérias g-1 solo seco. Foram obtidos 172 e 174 isolados, respectivamente para as amostras de inverno e verão, dos quais 30 e 55 % apresentaram similaridade igual ou superior a 70 % com as estirpes-tipo Azospirillum brasilense, A. amazonense, A. lipoferum, Herbaspirillum seropedicae e Burkholderia brasilensis. O resultado do comportamento dos isolados com base na tolerância à salinidade nem sempre foi semelhante ao obtido pelas características fenotípicas culturais a 70 % de similaridade, sendo indicado para estudos complementares de diversidade desses organismos. As BDNS apresentam potencial de utilização em estudos de avaliação da qualidade e sustentabilidade de ecossistemas. No entanto, apesar da alta densidade e diversidade fenotípica em solos da reserva, maiores valores foram obtidos no entorno, evidenciando o efeito positivo da cobertura vegetal do tipo gramíneas sobre elas, independentemente da variação climática.

  2. Investigación en materiales sometidos a altas presiones

    Directory of Open Access Journals (Sweden)

    Juan Carlos Fallas

    2010-10-01

    Full Text Available El estudio de materiales sometidos a altas presiones es un tema de profundo interés en el campo científico e ingenieril actual. Diferentes análisis experimentales permiten descubrir los efectos que esta condición genera en la estructura molecular de un determinado compuesto.La implementación de la celda de diamante para altas presiones ha revolucionado este tema en las últimas décadas, al ser una herramienta vital en el desarrollo de estas pruebas. Presiones superiores, inclusive a los 20 Gpa, pueden ser generadas con este artefacto.Adicionalmente, la posibilidad de caracterizar muestras bajo estos parámetros y la inclusión de otras variables, como altas temperaturas, ofrecen un ambiente propicio para la evaluación de materiales bajo condiciones extremas.Este artículo explica los fundamentos básicos de la ciencia de materiales a altas presiones. Aspectos relevantes acerca de la celda de diamante y de la ejecución de experimentos son tratados en diferentes apartados. Se quiere compartir los alcances que esta disciplina posee, así como diferentes resultados que se han logrado en varias aplicaciones.Investigaciones en materiales para el almacenamiento de hidrógeno y energía, así como la simulación de condiciones presentes a muy altas profundidades en la Tierra, son casos que se tomaron en cuenta para ejemplificar áreas donde existen aplicaciones sustanciales.

  3. Discordance of Non-HDL and Directly Measured LDL Cholesterol: Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?

    Directory of Open Access Journals (Sweden)

    Lawrence Baruch

    2013-01-01

    Full Text Available Objective. To determine if non-HDL cholesterol (N-HDL and directly measured LDL cholesterol (D-LDL are clinically equivalent measurements. Patients and Methods. Eighty-one subjects recruited for 2 cholesterol treatment studies had at least 1 complete fasting lipid panel and D-LDL performed simultaneously; 64 had a second assessment after 4 to 6 weeks, resulting in 145 triads of C-LDL, D-LDL, and N-HDL. To directly compare N-HDL to D-LDL and C-LDL, we normalized the N-HDL by subtracting 30 from the N-HDL (N-HDLA. Results. There was significant correlation between N-HDLA, D-LDL, and C-LDL. Correlation was significantly greater between N-HDLA and C-LDL than between N-HDLA and D-LDL. A greater than 20 mg/dL difference between measures was observed more commonly between N-HDLA and D-LDL, 29%, than between C-LDL and N-HDLA, 11% (P<0.001, and C-LDL and D-LDL, 17% (P=0.028. Clinical discordance was most common, and concordance was least common between N-HDL and D-LDL. Conclusions. Our findings suggest that N-HDL cholesterol and D-LDL cholesterol are not clinically equivalent and frequently discordant. As N-HDL may be superior to even C-LDL for predicting events in statin-treated patients, utilizing N-HDL to guide therapy would appear to be preferable to D-LDL when C-LDL is inaccurate.

  4. Caracterización de unidades biofísicas a partir de indicadores ambientales en Milpa Alta, Centro de México

    Directory of Open Access Journals (Sweden)

    María de Lourdes Rodríguez Gamiño

    2006-01-01

    Full Text Available En este trabajo se delimitaron y caracterizaron a las unidades biofísicas a partir de indicadores ambientales en Milpa Alta, Centro de México. Se trazaron las unidades geomorfológicas morfogenéticas que sirvieron de base para la caracterización de las unidades ambientales biofísicas (UAB. Se llevaron a cabo recorridos de campo para la verificación de las UAB y para la toma de muestras de suelos y levantamientos botánicos. En laboratorio se determinaron las propiedades físicas y químicas de los suelos. Se determinaron los indicadores de los factores de relieve, suelo, cobertura vegetal y uso de suelo. Las UAB se caracterizaron considerando los indicadores de relieve, pendiente y altitud; clima, temperatura y precipitación; suelo, humedad, materia orgánica, densidad aparente, pH; vegetación, densidad de la cobertura vegetal y uso de suelo. Las unidades se caracterizan por ser de origen endógeno volcánico acumulativo de flujos lávicos. Los tipos de relieve que predominan en los sitios muestreados son laderas de montaña superiores, medias e inferiores, de flujos lávicos; laderas de montaña superiores, internas y externas, de cono cinerítico; laderas superiores e inferiores de lomeríos medios y bajos; piedemonte acumulativo local; piedemonte acumulativo de lomeríos medios y bajos y planicie aluvial. La caracterización de las UAB mediante los indicadores ambientales permite contar con información básica para la toma de decisiones en el manejo adecuado de los recursos naturales y en la planeación socioambiental.

  5. Alta Velocità e innovazioni tecnologiche e funzionali

    Directory of Open Access Journals (Sweden)

    Emilia Giovanna Trifiletti

    2008-05-01

    Full Text Available La realizzazione di linee e di stazioni dell’Alta Velocità, oltre ad influire sullo sviluppo urbanistico delle aree interessate, sta cambiando radicalmente le relazioni spazio-temporali fra i diversi centri urbani connessi dalla rete del trasporto su ferro. Da un lato sono mutate le funzioni assunte dai contenitori-stazione e dall’altro sta mutando la domanda di trasporto che promuove, per le tratte coperte dalle linee dell’Alta Velocità, il treno rispetto all’aereo e alla macchina. In Italia, sulla scia del modello francese, il Gruppo Ferrovie dello Stato RFI, al fine di rendere più confortevole ed efficiente il viaggio sui treni ad Alta Velocità, ha dotato i nuovi treni di numerose innovazioni tecnologiche. Per quanto riguarda l’utilizzo di nuove tecnologie lungo le linee dell’A.V., l’articolo individua la variazione delle abitudini degli utenti al mutare dell’offerta dei servizi predisposti dalle compagnie trasportistiche. La tecnologia utilizzata sui nuovi treni dell’Alta Velocità cambia dunque il concept del viaggio: il valore aggiunto della tecnologia Wi-Fi introdotta sui treni rende la scelta del trasporto su ferro più produttiva rispetto gli altri modi di trasporto quali la macchina o l’aereo. La finalità dell’articolo è da un lato individuare il ruolo urbano assunto delle stazioni dell’Alta Velocità e dall’altro evidenziare come al mutare dell’offerta di trasporto, in termini di servizi offerti ad alto contenuto tecnologico, muta contestualmente anche la domanda di trasporto sul territorio e come tutto questo incida dunque sul governo delle trasformazioni territoriali. Questo è il nuovo importante ruolo della pianificazione: alcune delle nostre più importanti città stanno radicalmente trasformandosi proprio inserendo nei loro cuori le stazioni dell’Alta Velocità come elementi-chiave di accessibilità, vitale per la competitività in tutti i settori economici. Allo stesso modo le stazioni

  6. Efecto de la época de plantación en la dinámica de la emergencia de caña semilla de alta calidad (termotratada y micropropagada) de las variedades CP 65-357 y LCP 85-384 Effect of planting date on emergence dynamics of high quality CP 65-357 and LCP 85-384 seed cane (hot-water treated and micropropagated)

    OpenAIRE

    Patricia A. Digonzelli; Eduardo R. Romero; Jorge Scandaliaris; Juan Giardina; Osvaldo Arce

    2005-01-01

    Se evalúa el efecto de la época de plantación en la dinámica de la emergencia de caña semilla de alta calidad (micropropagada y termotratada) de las variedades CP 65-357 y LCP 85-384, en condiciones de disponibilidad hídrica adecuada. La caña semilla micropropagada y termotratada (50ºC, 2 hs) se plantó, con una densidad de 15 yemas/m, en tres épocas contrastantes: otoño, invierno y primavera. El material empleado estaba libre de escaldadura de la hoja (Xanthomonas albilineans) y achaparramien...

  7. Densidad poblacional y uso del hábitat de la codorniz Moctezuma (Cyrtonyx montezumae) en Hualtepec, Hidalgo

    OpenAIRE

    Lilia Hernández Palafox; Germán David Mendoza Martínez; Juan Ignacio Valdez Hernández; José Luis Alcántara Carbajal; Fernando Clemente Sánchez; Marivel Hernández Téllez

    2007-01-01

    El presente estudio se realizó para determinar la densidad poblacional y el uso del hábitat de la codorniz Moctezuma (Cyrtonyx montezumae) en Hualtepec, Hidalgo, México, en tres tipos de vegetación: bosque, pastizal y zona de transición (ecotono). Dicho sitio se localiza en el extremo oeste de Hidalgo, con área de muestreo de 5 715 ha. Se realizó un muestreo en 55 unidades, para evaluar el uso del hábitat por medio de indicios (excretas, rascaderos, plumas y nidos), y densidad de pob...

  8. Caracterización de las densidades en autómatas celulares binarios unidimensionales con retardo

    OpenAIRE

    José Manuel Gómez Soto; McIntosh, Harold V.

    2010-01-01

    La caracterización de las densidades de los autómatas celulares es un tema relevante en el estudio de estos modelos. Los autómatas celulares se han utilizado en muchas aplicaciones tales como la modelación de problemas de dinámica de fluidos, el estudio de materiales magnéticos en el procesamiento de imágenes, etcétera. Una caracterización de la densidad de estos autómatas permite realizar estudios matemáticos más profundos de los fenómenos que simulan. En este trabajo se propone caracterizar...

  9. Estructura metropolitana y funciones de densidad residencial. El caso de la región metropolitana de Barcelona

    OpenAIRE

    Muñiz, Iván; Galindo, Anna

    2006-01-01

    La relación que se establece entre el nivel de densidad residencial y la accesibilidad al lugar de empleo en el interior de una área urbana parece ser más compleja que la supuesta en el Modelo de Ciudad Monocéntrica. Las estimaciones de funciones de densidad residencial más simples, sustentadas en un modelo teórico que suponía una concentración total del empleo en el distrito central y que utilizaban como única medida de accesibilidad la distancia al centro, han dado paso a estimaciones más s...

  10. Variaciones en la densidad del oxígeno en el aire y su influencia sobre la salud humana

    OpenAIRE

    Olcina Cantos, Jorge; Martín Estévez, David

    2012-01-01

    La falta de oxígeno puede conllevar serias consecuencias en la salud de los seres vivos, incluida la muerte. La modificación de su densidad en el aire pueda tener efectos sobre la salud humana, especialmente en grupos de riesgo y personas con afecciones pulmonares o cardiacas previas. Se analiza el efecto de las variaciones en la densidad de oxígeno, originadas por los cambios en las masas de aire presentes en la atmósfera, sobre los ingresos hospitalarios por enfermedad cardiaca y vásculo-ce...

  11. Densidad poblacional del venado cola blanca (Odocoileus virginianus) en sabana inindable de Paz De Ariporo (Casanare), Orinoquia colombiana

    OpenAIRE

    Montenegro Olga Lucía; Pérez Moreno Heidi Yohana

    2006-01-01

    Esta investigación buscó estimar y analizar las diferencias en la densidad poblacional del venado cola blanca
    (Odocoileus virginianus) en dos hatos de la Orinoquia colombiana, con miras a aportar elementos para su manejo
    sostenible en la región. Para la estimación de densidad se realizaron conteos de individuos y grupos en transectos
    lineales de ancho variable acumulando 54,3 km y 48,65 km en los hatos Taparas y Miramar respectivamente.
    Estos recorr...

  12. Densidad poblacional y uso del hábitat de la codorniz Moctezuma (Cyrtonyx montezumae) en Hualtepec, Hidalgo

    OpenAIRE

    Lilia Hernández Palafox; Germán David Mendoza Martínez; Juan Ignacio Valdez Hernández; José Luis Alcántara Carbajal; Fernando Clemente Sánchez; Marivel Hernández Téllez

    2007-01-01

    El presente estudio se realizó para determinar la densidad poblacional y el uso del hábitat de la codorniz Moctezuma (Cyrtonyx montezumae) en Hualtepec, Hidalgo, México, en tres tipos de vegetación: bosque, pastizal y zona de transición (ecotono). Dicho sitio se localiza en el extremo oeste de Hidalgo, con área de muestreo de 5 715 ha. Se realizó un muestreo en 55 unidades, para evaluar el uso del hábitat por medio de indicios (excretas, rascaderos, plumas y nidos), y densidad de población, c...

  13. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

    Science.gov (United States)

    Voight, Benjamin F; Peloso, Gina M; Orho-Melander, Marju; Frikke-Schmidt, Ruth; Barbalic, Maja; Jensen, Majken K; Hindy, George; Hólm, Hilma; Ding, Eric L; Johnson, Toby; Schunkert, Heribert; Samani, Nilesh J; Clarke, Robert; Hopewell, Jemma C; Thompson, John F; Li, Mingyao; Thorleifsson, Gudmar; Newton-Cheh, Christopher; Musunuru, Kiran; Pirruccello, James P; Saleheen, Danish; Chen, Li; Stewart, Alexandre FR; Schillert, Arne; Thorsteinsdottir, Unnur; Thorgeirsson, Gudmundur; Anand, Sonia; Engert, James C; Morgan, Thomas; Spertus, John; Stoll, Monika; Berger, Klaus; Martinelli, Nicola; Girelli, Domenico; McKeown, Pascal P; Patterson, Christopher C; Epstein, Stephen E; Devaney, Joseph; Burnett, Mary-Susan; Mooser, Vincent; Ripatti, Samuli; Surakka, Ida; Nieminen, Markku S; Sinisalo, Juha; Lokki, Marja-Liisa; Perola, Markus; Havulinna, Aki; de Faire, Ulf; Gigante, Bruna; Ingelsson, Erik; Zeller, Tanja; Wild, Philipp; de Bakker, Paul I W; Klungel, Olaf H; Maitland-van der Zee, Anke-Hilse; Peters, Bas J M; de Boer, Anthonius; Grobbee, Diederick E; Kamphuisen, Pieter W; Deneer, Vera H M; Elbers, Clara C; Onland-Moret, N Charlotte; Hofker, Marten H; Wijmenga, Cisca; Verschuren, WM Monique; Boer, Jolanda MA; van der Schouw, Yvonne T; Rasheed, Asif; Frossard, Philippe; Demissie, Serkalem; Willer, Cristen; Do, Ron; Ordovas, Jose M; Abecasis, Gonçalo R; Boehnke, Michael; Mohlke, Karen L; Daly, Mark J; Guiducci, Candace; Burtt, Noël P; Surti, Aarti; Gonzalez, Elena; Purcell, Shaun; Gabriel, Stacey; Marrugat, Jaume; Peden, John; Erdmann, Jeanette; Diemert, Patrick; Willenborg, Christina; König, Inke R; Fischer, Marcus; Hengstenberg, Christian; Ziegler, Andreas; Buysschaert, Ian; Lambrechts, Diether; Van de Werf, Frans; Fox, Keith A; El Mokhtari, Nour Eddine; Rubin, Diana; Schrezenmeir, Jürgen; Schreiber, Stefan; Schäfer, Arne; Danesh, John; Blankenberg, Stefan; Roberts, Robert; McPherson, Ruth; Watkins, Hugh; Hall, Alistair S; Overvad, Kim; Rimm, Eric; Boerwinkle, Eric; Tybjaerg-Hansen, Anne; Cupples, L Adrienne; Reilly, Muredach P; Melander, Olle; Mannucci, Pier M; Ardissino, Diego; Siscovick, David; Elosua, Roberto; Stefansson, Kari; O'Donnell, Christopher J; Salomaa, Veikko; Rader, Daniel J; Peltonen, Leena; Schwartz, Stephen M; Altshuler, David; Kathiresan, Sekar

    2012-01-01

    Summary Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. Methods We performed two mendelian randomisation analyses. First, we used as an instrument a single nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser) and tested this SNP in 20 studies (20 913 myocardial infarction cases, 95 407 controls). Second, we used as an instrument a genetic score consisting of 14 common SNPs that exclusively associate with HDL cholesterol and tested this score in up to 12 482 cases of myocardial infarction and 41 331 controls. As a positive control, we also tested a genetic score of 13 common SNPs exclusively associated with LDL cholesterol. Findings Carriers of the LIPG 396Ser allele (2·6% frequency) had higher HDL cholesterol (0·14 mmol/L higher, p=8×10−13) but similar levels of other lipid and non-lipid risk factors for myocardial infarction compared with non-carriers. This difference in HDL cholesterol is expected to decrease risk of myocardial infarction by 13% (odds ratio [OR] 0·87, 95% CI 0·84–0·91). However, we noted that the 396Ser allele was not associated with risk of myocardial infarction (OR 0·99, 95% CI 0·88–1·11, p=0·85). From observational epidemiology, an increase of 1 SD in HDL cholesterol was associated with reduced risk of myocardial infarction (OR 0·62, 95% CI 0·58–0·66). However, a 1 SD increase in HDL cholesterol due to genetic score was not associated with risk of myocardial infarction (OR 0·93, 95% CI 0·68–1·26, p=0·63). For LDL cholesterol, the estimate from observational epidemiology (a 1 SD increase in LDL cholesterol

  14. Variación espacio-temporal de la densidad poblacional de erizo rojo Strongylocentrotus franciscanus (Echinodermata: Echinoidea: Strongylocentrotidae en Baja California Spatial and temporal variation of the population density of the red sea urchin Stronngylocenntrotus franciscanus (Echinodermata: Echinoidea: Strongylocentrotidae in Baja California

    Directory of Open Access Journals (Sweden)

    Julio S. Palleiro-Nayar

    2012-04-01

    Full Text Available Se estimó la densidad poblacional de erizo rojo, Strongylocentrotus franciscanus, en 10 localidades de la costa occidental de Baja California, México, donde se realiza la extracción comercial de este recurso pesquero. Se compararon las estimaciones realizadas en cuatro años muestreados: 2003, 2005, 2006 y 2008. Las variaciones observadas en las localidades analizadas indicaron diferencias espacio-temporales para la densidad de erizo rojo y diferencias en la estructura de tallas, las cuales estuvieron influenciadas principalmente por la intensidad de la pesca y al esporádico reclutamiento en cada sitio. Se encontraron dos localidades (Isla San Jerónimo y Arrecife Sacramento que destacaron por presentar una alta densidad de erizo rojo y una amplia estructura de tallas, predominando individuos de tallas entre 50 a 80 mm diámetro de caparazón, lo que podría indicar que la intensidad de pesca aparentemente tiene un menor efecto que en los otros sitios.Density estimations of red sea urchin Strongylocentrotus franciscanus were recorded in ten sites with commercial fisheries on the west coast of Baja California, Mexico. The estimations for the years 2003, 2005, 2006 and 2008 were compared. The variations observed in the study sites indicate important spatial and temporal differences in density and size structure, influenced by fishing intensity and sporadic recruitment in each site. We found two sites (San Jeronimo Island and Sacramento Reef with a high density and wide size structure; with a predominance of individuals of sizes from 50 to 80 mm with lest impact possible in fishing mortality for all sites.

  15. The usefulness of information on HDL-cholesterol: potential pitfalls of conventional assumptions

    OpenAIRE

    Furberg Curt D

    2001-01-01

    Abstract Treatment decisions related to disease prevention are often based on two conventional and related assumptions. First, an intervention-induced change in a surrogate marker (such as high-density lipoprotein [HDL]-cholesterol) in the desired direction translates into health benefits (such as reduction in coronary events). Second, it is unimportant which interventions are used to alter surrogate markers, since an intervention benefit is independent of the means by which it is achieved. T...

  16. Oxidised LDL, HDL cholesterol, LDL cholesterol levels in patients of coronary artery disease

    OpenAIRE

    Ghosh, Joya; T K Mishra; Rao, Y. N.; Aggarwal, S. K.

    2006-01-01

    Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol, high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and sex matched normal healthy individuals were taken as controls and 60 patients of CAD were taken. Cholesterol was measured by enzymatic method,...

  17. Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis[S

    OpenAIRE

    Arakawa, Reijiro; Tsujita, Maki; Iwamoto, Noriyuki; Ito-Ohsumi, Chisato; Lu, Rui; Wu, Chen-Ai; Shimizu, Kenji; Aotsuka, Tomoji; Kanazawa, Hashime; Abe-Dohmae, Sumiko; Yokoyama, Shinji

    2009-01-01

    Expression of ABCA1 is regulated by transcription of the gene and calpain-mediated proteolytic degradation, and inhibition ABCA1 degradation results in increased ABCA1 and HDL biogenesis in vitro. We examined whether this approach could be a potential antiatherogenic treatment. Although probucol inhibits both the activity and degradation of ABCA1, its oxidized products, spiroquinone and diphenoquinone, reduce degradation of ABCA1 without inhibiting its activity or altering transcription of th...

  18. ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression

    DEFF Research Database (Denmark)

    Burillo, Elena; Lindholt, Jes S.; Molina-Sánchez, Pedro;

    2015-01-01

    proteomic analysis of plasma proteins was performed in AAA patients at different stages of evolution [small AAA (aortic size=3-5 cm) vs large AAA] using iTRAQ labelling, high-throughput nano-LC-MS/MS and a novel multi-layered statistical model. Among the proteins identified, ApoA-I was decreased in patients...... with large AAA compared to those with small AAA. These results were validated by ELISA on plasma samples from small (n=90) and large AAA (n=26) patients (150± 3 vs 133± 5 mg/dl, respectively, p< 0.001). ApoA-I levels strongly correlated with HDL-Cholesterol (HDL-C) concentration (r=0.9, p< 0.001) and......=23,496) (0.89± 2.99 vs 1.59± 5.74 mmol/l, p< 0.001). Finally, reduced mean aortic AAA diameter was observed in AngII-infused mice treated with ApoA-I mimetic peptide compared with saline-injected controls. In conclusion, ApoA-I/HDL-C systemic levels are negatively associated with AAA evolution...

  19. Low HDL cholesterol as a cardiovascular risk factor in rural, urban, and rural-urban migrants: PERU MIGRANT cohort study

    Science.gov (United States)

    Lazo-Porras, María; Bernabe-Ortiz, Antonio; Málaga, Germán; Gilman, Robert H.; Acuña-Villaorduña, Ana; Cardenas-Montero, Deborah; Smeeth, Liam; Miranda, J. Jaime

    2016-01-01

    Introduction Whilst the relationship between lipids and cardiovascular mortality has been well studied and appears to be controversial, very little has been explored in the context of rural-to-urban migration in low-resource settings. Objective Determine the profile and related factors for HDL-c patterns (isolated and non-isolated low HDL-c) in three population-based groups according to their migration status, and determine the effect of HDL-c patterns on the rates of cardiovascular outcomes (i.e. non-fatal stroke and non-fatal myocardial infarction) and mortality. Methods Cross-sectional and 5-year longitudinal data from the PERU MIGRANT study, designed to assess the effect of migration on cardiovascular risk profiles and mortality in Peru. Two different analyses were performed: first, we estimated prevalence and associated factors with isolated and non-isolated low HDL-c at baseline. Second, using longitudinal information, relative risk ratios (RRR) of composite outcomes of mortality, non-fatal stroke and non-fatal myocardial infarction were calculated according to HDL-c levels at baseline. Results Data from 988 participants, rural (n = 201), rural-to-urban migrants (n = 589), and urban (n = 199) groups, was analysed. Low HDL-c was present in 56.5% (95%CI: 53.4%–59.6%) without differences by study groups. Isolated low HDL-c was found in 36.5% (95%CI: 33.5–39.5%), with differences between study groups. In multivariable analysis, urban group (vs. rural), female gender, overweight and obesity were independently associated with isolated low HDL-c. Only female gender, overweight and obesity were associated with non-isolated low HDL-c. Longitudinal analyses showed that non-isolated low HDL-c increased the risk of negative cardiovascular outcomes (RRR = 3.46; 95%CI: 1.23–9.74). Conclusions Isolated low HDL-c was the most common dyslipidaemia in the study population and was more frequent in rural subjects. Non-isolated low HDL-c increased three-to fourfold

  20. Estabilidad y funcionalidad de sellantes dentales en altas temperaturas ambientales

    OpenAIRE

    Mishina, Anastasia; Mayelín Guerra, Rosa; Durán Ramos, Ivette; Juan D. Sabatier

    2000-01-01

    Los sellantes dentales son materiales que se emplean en estomatología para sellar las fosas y fisuras oclusales de los dientes y evitar la adherencia del estreptococus mutans agente que produce la caries dental. Estos materiales se suministran en dos partes que al mezclarse producen el endurecimiento de la resina. Sin embargo, estos productos presentan dificultades para su comercialización en los países tropicales, debido a que las altas temperaturas ambientales traen problemas en...

  1. Luces y sombras de la lectura en voz alta

    OpenAIRE

    Cassany, Daniel

    2007-01-01

    En el siguiente artículo aborda una práctica tan extendida en las aulas de todos los niveles educativos como es la lectura en voz alta. A partir de su experiencia personal y profesional, formula un análisis ameno, provocador y fundamentado, una constante en sus textos y conferencias, que suscitará en el lector docente nuevas perspectivas acerca de su trabajo.

  2. Cuaderno de Prácticas: Altas Capacidades

    OpenAIRE

    García Fernández, José Manuel; Vicent Juan, Maria; Gonzálvez Macià, Carolina

    2016-01-01

    Este material, centrado en el estudio de las Altas Capacidades, pretende favorecer la adquisición de destrezas en el conocimiento e intervención en el ámbito de la educación especial para conocer de primera mano las diferentes formas que se tienen para actuar e intervenir ante niños con necesidades específicas de apoyo educativo.

  3. Los colosos del campo: tractores de alta potencia

    OpenAIRE

    Moya Gonzalez, Adolfo; Diezma Iglesias, Belen

    2014-01-01

    Revisión y descripción de las principales características de los tractores de alta potencia en el sector agrícola español. La agricultura profesional es una empresa compleja y la inversión en formación de los agentes implicados en el sector (agricultores e ingenieros) es la llave para conseguir aprovechar toda la tecnología disponible y optimizar los recursos usados.

  4. Cócs. Hallmark of the Terra Alta

    Directory of Open Access Journals (Sweden)

    Maria Del Loreto Meix

    2004-04-01

    Full Text Available This article looks at the traditional cake making in the Terra Alta (Catalonien area linked to festivities, and in particular the pastries usually made. In this area the pastries are known as cócs, a word common to Terra Alta and the neighbouring districts of Ribera d'Ebre and the Priorat. Locally produced mistelle, sweet or rancid wine is served with the pastries. Nowadays, the bakeries and cake makers in the area's towns and villages also produce traditionally crafted products, that used only to be homemade.The article, resulting from the final degree project produced by the author for her Humanities degree at the UOC, offers a privileged look at the richness of the Terra Alta in terms of its gastronomic history, customs and its high regard for its cakes. The author, who has previous experience in the field, places the specific aspects of Terra Alta cake making in the context of the Mediterranean cultures with common roots dating back to the ancient and medieval worlds and which still have an easily identifiable "family feel", whilst looking, from an ethnographic point of view, at what she calls the "world of wheat" in the area, (the dough for bread, the craft of the baker, the ovens and other tools, and the associated traditions, among other things. In short, she rescues a living part of the local day-to-day activities and places it under the microscope of food history, whilst providing information that may well be of interest for study from other points of view.

  5. Caracterización morfométrica de la cuenca alta del río Sauce Grande.

    Directory of Open Access Journals (Sweden)

    Fernanda Julia Gaspari

    2013-01-01

    Full Text Available La cuenca alta del río Sauce Grande abastece el complejo hidráulico Embalse Paso de las Piedras, comportándose como servicio ambiental primordial para el consumo hídrico de Bahía Blanca. El análisis de las características morfométricas y funcionales de una cuenca hidrográfica a través de parámetros de forma, relieve y red de drenaje, es básico en la modelación hidrológica para determinar el movimiento y captación del agua de lluvia. Estos indicadores pueden apoyar una formulación de un Sistema de Pago por Servicios Ambientales, como estrategia básica de ordenamiento territorial y desarrollo local, centrado en la oferta de agua generada por la cuenca. El objetivo fue caracterizar morfométricamente la cuenca alta del río Sauce Grande. La metodología aplicada se basó en establecer y analizar los parámetros morfométricos mediante el uso de Sistemas de Información Geográfica y planillas de cálculo, a partir de un modelo digital del terreno e imágenes satelitales. Los resultados alcanzados definieron que la cuenca posee un área de 1502.6 km2. La longitud axial es de 41.6 km con un ancho promedio de 36.1 km. El Factor de forma (0.87 indica que posee forma alargada, siendo rectangular oblonga según el coeficiente de compacidad de Gravelius (2.8. La longitud del cauce principal es 58.34 km con pendiente media de 0.48 %. La densidad de drenaje es 0.27 km.km-2 y su coeficiente de sinuosidad 1.42. El tiempo de concentración es 11.8 hs. La curva hipsométrica adimensional corresponde a una cuenca con un avanzado grado de desarrollo. Todos estos parámetros facilitan la cuantificación del caudal líquido en la cuenca.

  6. Weather, cultivar and density-dependent processes influence on aphid in alfalfa Influência do clima, da cultivar e de processos dependentes da densidade sobre afídeos em alfafa

    Directory of Open Access Journals (Sweden)

    Alexandre de Almeida e Silva

    2007-01-01

    Full Text Available It is important to understand the effects of weather, insect density and plant cultivar on insect abundance to predict and prevent crop production loss. The present work investigated the influence of such factors on aphid in alfalfa during one year (short term. Data was collected from September/1997 to August/1998 at Canchin Farm (CCPSE-EMBRAPA, São Carlos, State of São Paulo, Brazil. Weather conditions had, in general, little effect on the variation of aphid populations, but Therioaphis maculata abundance was negatively correlated to humidity. Moreover, high maximum temperatures and low levels of rainfall possible favored T. maculata high abundance on Crioula and P3 cultivars. Therefore, appropriate management of this species is required during hot and dry periods. Population variation of Acyrthosiphon spp., T. maculata and Aphis craccivora seems to be regulated by density dependent processes. Resistant cultivar CUF 101 had a lower abundance of T. maculata and A. craccivora and a narrower population variation than the other cultivars and may reduce their abundance on field. Long-term studies on population dynamics including the effect of climatic conditions and density-dependent factors on plant quality will contribute to pest management in alfalfa fields.É importante entender os efeitos do clima, da densidade dos insetos e da cultivar sobre a abundância de insetos para se predizer e prevenir perdas na produção das culturas. O objetivo do presente trabalho foi analisar a influência desses fatores sobre afídeos em alfafa no período de um ano. Os dados foram coletados de setembro/1997 a agosto/1998 na Fazenda Canchin (CPPSE-EMBRAPA, São Carlos, São Paulo, Brasil. As condições climáticas, em geral, tiveram pequeno efeito sobre a variação populacional dos afídeos, mas a abundância de Therioaphis maculata esteve negativamente correlacionada à umidade. Além disso, as altas temperaturas máximas e os baixos níveis de precipita

  7. CRECIMIENTO Y PRODUCTIVIDAD DE CHAYA (Cnidoscolus chayamansa MCVAUGH, EUPHORBIACEAE) CON DENSIDAD DE PLANTACIÓN VARIABLE

    OpenAIRE

    Jesús Mao E. Aguilar Luna; Pedro A. Macario Mendoza; Esperanza Huerta Lwanga; Salvador Hernández Daumás; Ramiro de Alba Becerra; Eduardo García Villanueva

    2011-01-01

    Se evaluó el efecto que tiene la competenciainterespecífica en el crecimiento y la productividad de la chayacon densidad de plantación (DP) variable, en un suelocalcimórfico de tipo rendzina negra en Noh-Bec, Quintana Roo,México. La chaya se estableció a 1.50 x 3.00 m, utilizando estacassin hojas; se asoció con árboles jóvenes (menores de dosaños) de Cedrela odorata y Citrus latifolia en un diseño deplantación en círculo 'Nelder' de 3154 m2. Se establecieron ochoDP de 2602 a 3772 plantas.ha-1...

  8. EFECTO DEL RALEO SOBRE EL CRECIMIENTO Y LA DENSIDAD DE LA MADERA DE Pinus taeda IMPLANTADO EN MISIONES, ARGENTINA

    Directory of Open Access Journals (Sweden)

    Rodolfo Martiarena

    2014-01-01

    Full Text Available El mayor incremento en crecimiento de la plantación puede causar variación en las propiedades físicas de la madera, pudiendo disminuir la calidad de la misma para la industria. El objetivo del presente trabajo es evaluar el efecto de los tratamientos de raleo sobre el crecimiento y densidad de la madera de Pinus taeda implantado en Misiones, Argentina (25º 59’S - 54º24’O. La plantación se estableció en 1985 con densidad inicial de 1644 pl.ha -1 y se manejó con tres intensidades de raleo (0, 33 y 66 % del área basal del testigo sin ralear, bajo un diseño de bloques completos al azar (3 bloques. A los 20 años se efectuó tala rasa, cuyas densidades eran 711 (0 %, 364 (33 % y 122 (66 % plantas por hectárea, momento en el cual se seleccionaron 45 árboles para determinar la densidad básica de la madera. La misma se determinó a través de la realización de 2.700 probetas. El crecimiento de la plantación fue afectado por la intensidad de raleo, registrando diámetros promedio de 28,7, 34,8 y 45,9 cm, respectivamente, en los tratamientos 0, 33 y 66 % de raleo. El volumen de la plantación, al momento del apeo, fue superior en el tratamiento sin raleo, no obstante el tratamiento 66 % de raleo generó mayor cantidad de madera de grandes dimensiones. La densidad básica como promedio simple y ponderado por volumen no presentó diferencias significativas entre tratamientos. Los valores de densidad ponderada fueron de 0,406, 0,418 y 0,420 g.cm -3 para los tratamientos 0, 33 y 66 % de raleo, respectivamente, mientras que el análisis de correlación entre diámetro y densidad no fue significativo. El estudio mostró que la intensidad de raleo puede ser manejada para maximizar la producción, manteniendo idéntica la calidad de la madera para la industria.

  9. Parâmetros sangüíneos de pacu Piaractus mesopotamicus (Holmberg, 1887 alimentados com dietas suplementadas com cromo trivalente em duas densidades de estocagem - DOI: 10.4025/actascianimsci.v29i4.1019 Hematological parameters of pacu Piaractus mesopotamicus (Holmberg, 1887 fed diets supplemented with trivalent chromium in two stocking densities - DOI: 10.4025/actascianimsci.v29i4.1019

    Directory of Open Access Journals (Sweden)

    Flávio Ruas de Moraes

    2008-03-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos da suplementação com cromo trivalente (0, 6, 12 e 18 mg kg-1 de ração sobre as variáveis hematológicas de Piaractus mesopotamicus, mantidos em duas densidades de estocagem (4 e 20 kg m-3. Os mantidos na maior densidade e alimentados com dietas suplementadas com 0 e 6 mg de cromo kg-1 apresentaram redução do número de linfócitos circulantes, sugerindo má adaptação a essa condição de alta densidade. Nas dietas suplementadas com 12 e 18 mg kg-1, tal efeito não foi observado, porém verificou-se aumento do número de trombócitos no tratamento com 12 mg de cromo kg-1. A inexistência de diferença significativa entre os tratamentos, aos 30 dias, sugere a adaptação dos peixes ao tipo de alimento e à situação de alta densidade. Portanto, nas condições deste ensaio, a suplementação com 12 e 18 mg de cromo kg-1 é interessante como estratégia alimentar durante 15 dias.This work evaluated the effects of chromium supplementation on the hematological parameters of Piaractus mesopotamicus Holmberg, 1887 maintained in two stocking densities. Fish were fed diets supplemented with 0, 6, 12 and 18 mg trivalent chromium kg-1 dry ration and maintained at 4 and 20 kg m-3. The fish under high stocking density and fed diets supplemented with 0 and 6 mg kg-1 showed reduction in the number lymphocytes, which suggests non-adaptation to this condition of high density. This was not observed in fish fed diets supplemented with 12 and 18 mg chromium kg-1, but an increase in the number of thrombocytes was evident. The lack of difference between treatments after 30 days may suggest a possible adaptation of fish to the situation. It can be added that supplementation with 12 and 18 mg chromium kg-1 is an interesting feeding strategy for a period of 15 days.

  10. Espaçamento, densidade populacional e adubação nitrogenada na cultura do milho Row spacing, population density and nitrogen fertilization in maize

    Directory of Open Access Journals (Sweden)

    José Pedro Ribeiro do Amaral Filho

    2005-06-01

    Full Text Available A distribuição espacial de plantas por área é um recurso para aumentar a produtividade. Para materiais de alta produtividade, são necessárias mais informações quanto à resposta à adubação nitrogenada. Assim, avaliou-se na cultura do milho a influência do espaçamento, da densidade populacional e de doses de nitrogênio no teor de nitrogênio nas folhas, estimativa do teor de clorofila, número de grãos por espiga, massa de 1.000 grãos, produtividade e teor de proteína nos grãos. O trabalho foi instalado no ano agrícola 2000/2001 e constou de tratamentos representados pela combinação de dois espaçamentos entre as linhas (0,80 e 0,60 m com três densidades populacionais (40, 60 e 80.000 plantas ha-1 e quatro doses de nitrogênio em cobertura (0, 50, 100 e 150 kg ha-1 N. O aumento na doses de N em cobertura promoveram acréscimo no teor de N foliar, na estimativa do teor de clorofila, no número de grãos por espiga, na massa de 1.000 grãos, na produtividade e no teor de proteína nos grãos de milho. A maior produtividade de grãos foi obtida de acordo com as doses crescentes de N em cobertura juntamente com o espaçamento entre as linhas de 0,80 m e 80.000 plantas ha-1.The alteration of spatial distribution of plants is an option to increase the grain yield. For high-yielding materials more information about the influence of nitrogen fertilization is needed. Thus, the influence of row spacing, population densities and nitrogen rates on the leaf nitrogen concentration, estimated concentration of chlorophyll, number of grains per ear, mass of thousand grains, grain yield, and protein content were evaluated. This study was carried out in the 2000/2001growth season; the treatments were two row spacings (0.60 and 0.80 m; three population densities (40,000, 60,000 and 80,000 plants ha-1 and four nitrogen rates (0, 50, 100, and 150 kg ha-1 N. Increased nitrogen rates in top dressing led to a increase in the leaf nitrogen and

  11. HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function.

    Science.gov (United States)

    Berisha, Stela Z; Brubaker, Greg; Kasumov, Takhar; Hung, Kimberly T; DiBello, Patricia M; Huang, Ying; Li, Ling; Willard, Belinda; Pollard, Katherine A; Nagy, Laura E; Hazen, Stanley L; Smith, Jonathan D

    2015-03-01

    HDL functions are impaired by myeloperoxidase (MPO), which selectively targets and oxidizes human apoA1. We previously found that the 4WF isoform of human apoA1, in which the four tryptophan residues are substituted with phenylalanine, is resistant to MPO-mediated loss of function. The purpose of this study was to generate 4WF apoA1 transgenic mice and compare functional properties of the 4WF and wild-type human apoA1 isoforms in vivo. Male mice had significantly higher plasma apoA1 levels than females for both isoforms of human apoA1, attributed to different production rates. With matched plasma apoA1 levels, 4WF transgenics had a trend for slightly less HDL-cholesterol versus human apoA1 transgenics. While 4WF transgenics had 31% less reverse cholesterol transport (RCT) to the plasma compartment, equivalent RCT to the liver and feces was observed. Plasma from both strains had similar ability to accept cholesterol and facilitate ex vivo cholesterol efflux from macrophages. Furthermore, we observed that 4WF transgenic HDL was partially (∼50%) protected from MPO-mediated loss of function while human apoA1 transgenic HDL lost all ABCA1-dependent cholesterol acceptor activity. In conclusion, the structure and function of HDL from 4WF transgenic mice was not different than HDL derived from human apoA1 transgenic mice. PMID:25561462

  12. Fitomorfologia e produção de cultivares de trigo duplo propósito em diferentes manejos de corte e densidades de semeadura Phytomorphology and production of dual purpose wheat with different cutting regimes and seeding density

    Directory of Open Access Journals (Sweden)

    Thomas Newton Martin

    2010-08-01

    Full Text Available A diversificação de cultivares e finalidades da cultura do trigo podem alterar as indicações de manejo no sistema de integração lavoura-pecuária. Dessa forma, este trabalho tem como objetivo verificar o desempenho das cultivares de trigo duplo propósito em diferentes densidades de semeadura, com e sem corte. As cultivares de trigo utilizados foram: 'BRS Figueira', 'BRS Guatambu', 'BRS Tarumã' e 'BRS Umbu', e as densidades de semeadura utilizadas foram de 50, 200, 350, 500 e 650 sementes por metro quadrado. As variáveis fitomorfológicas e de produção possuem um desempenho diferenciado conforme a cultivar, o manejo e a densidade de semeadura. A cultivar 'Figueira' possui o maior potencial produtivo dentro dos limites de densidades estudados quanto à produção de massa seca, em relação aos demais cultivares. A produção de grãos teve interação significativa entre as cultivares e o manejo (com e sem corte. As cultivares com maiores produções de grãos foram, respectivamente, 'Figueira', 'Umbu', 'Tarumã' e 'Guatambu' no manejo sem corte, já no sistema com corte a cultivar 'Tarumã' foi a que obteve o maior rendimento de grãos, diferenciando-se das demais. A maioria das correlações altas e significativas ocorreu nos manejos com e sem corte. O corte diminuiu todos os valores dos componentes de rendimento, bem como a produção de grãos de todos as cultivares.The diversification of cultivars and purposes of wheat crop may alter the information management system of crop-livestock integration. Therefore, this research has the objective to verify the performance of dual purpose wheat with different cutting regimes and seeding density. The whet cultivate used were: 'BRS Figueira', 'BRS Guatambu', 'BRS Tarumã' and 'BRS Umbu'. The seeding density was of 50, 200, 350, 500 and 650 seeds for square meter. The phitomorfological and production variables have a different performance depending on as cultivar, management and seeding

  13. Use of solaria to predict weed density and floristic composition in no-till cropping systems Uso de solaria na predição da densidade de ervas daninhas e da composição florística no sistema de semeadura direta

    Directory of Open Access Journals (Sweden)

    Pablo Antonio Calviño

    2006-03-01

    a densidade de espécies com densidades altas e baixas de indivíduos em áreas de 10 ha com o uso apenas de cinco solaria. Espécies com baixas densidades tornam o método particularmente útil para ajudar a decidir o uso ou não de herbicidas para evitar a contaminação da terra.

  14. TransForm: TransAlta 2000 annual report

    International Nuclear Information System (INIS)

    Financial information from TransAlta Corp. was presented along with a review of their operations throughout 2000 and a summary of the how the electric utility is doing in terms of power generation, independent power producers, transmission and energy marketing. The utility has changed from a regulated vertically integrated utility into one of Canada's largest non-regulated electric power generators. The utility sold its retail businesses in Alberta and New Zealand and now focuses on coal and hydro generation, gas generation, high-voltage transmission and energy marketing. The newly constructed Centralia, Washington generation facility was brought on line with 1,340 MW in May 2000, on time and on budget. This was the platform to diversify their generation into the United States. The utility reported a solid financial year with $177.9 million in earnings from continuing operations, an 83 per cent increase from 1999, driven mostly by the results of Centralia and power marketing and trading businesses. A financial loss was suffered when the Wabamum power plant in Alberta was shut down for several months to repair a boiler. The utility made excellent progress toward their goal of 15,000 megawatts by 2005 by starting with the construction of what will be one of Canada's largest cogeneration facilities at Sarnia, Ontario. TransAlta also commissioned a 360 MW cogeneration facility at Poplar Creek at Suncor's Fort McMurray oil sand facility. TransAlta also has an excellent track record in developing power generation projects internationally. refs., tabs., figs

  15. Adsorption de PCB par des phases HDL organomodifiées

    OpenAIRE

    Dumas, Edith; Laforest, Valérie; De Roy, Marie-Elisabeth; Forano, Claude; Bourgois, Jacques

    2012-01-01

    Les PCB sont des polluants persistants pour lesquels il faut encore chercher des solutions permettant de les retirer des sédiments. Le lavage par des tensioactifs offre de bons rendements de nettoyage. Il faut ensuite traiter les eaux du lessivage. Les Hydroxydes Doubles Lamellaires (HDL) ont montré des capacités intéressantes pour l'adsorption de polluants. L'insertion de tensioactifs lors de la synthèse de ces matériaux permet d'intercaler des polluants hydrophobes entre les feuillets bruci...

  16. Alta disponibilidad para componentes de fabricación

    OpenAIRE

    Maciá Pérez, Francisco; Marcos Jorquera, Diego; Gilart Iglesias, Virgilio

    2006-01-01

    A medida que las tecnologías de la información van calando en el tejido productivo industrial, tanto más compleja se vuelve su organización. Es imprescindible introducir sistemas de gestión proactivos y autogestionados que aseguren su funcionamiento continuado y, en consecuencia, la continuidad en el negocio. En este artículo se propone un sistema de regeneración de los elementos de producción industrial que traslada el concepto de alta disponibilidad a los niveles de fabricación de la organi...

  17. Comportamiento a alta temperatura de paneles de cemento de magnesio

    OpenAIRE

    Tapia García, Mario

    2015-01-01

    El objeto principal de este proyecto final de máster es analizar el comportamiento a altas temperaturas de paneles de cemento de magnesio. Para completar el estudio se realiza un comparativo con paneles de alma de yeso, utilizados habitualmente en construcción. Dado su alto contenido en Cloruro de Magnesio, se marca como objetivo paralelo determinar si la dosificación de los diferentes componentes condiciona la cantidad de HCl emitido. Por último, se investiga la existencia de normas de refer...

  18. Endoscopia digestiva alta :análise de 100 exames

    OpenAIRE

    Afonso, Sofia Isabel Sousa

    2012-01-01

    Objetivo: Aplicando as indicações da American Society for Gastrointestinal Endoscopy (ASGE), um dos objetivos deste estudo foi avaliar o uso apropriado da Endoscopia Digestiva Alta (EDA) e a sua relação com os achados endoscópicos. A taxa de complicações e do uso da anestesia, as principais dificuldades, a tolerância e satisfação dos doentes também foram alvo de análise neste estudo. Métodos: Para este estudo prospetivo foram obtidos dados de 100 casos através de um inquérit...

  19. MCU para multiconferencias en alta definición

    OpenAIRE

    López Rubio, Javier

    2007-01-01

    En este trabajo se describen todos los pasos seguidos para el desarrollo de una MCU (Multipoint Control Unit), capaz de gestionar videoconferencias de alta definición. En el se incluyen las especificaciones y el diseño tanto a nivel de arquitectura como a nivel de aplicación. La MCU resultante es el resultado de la investigación que la fundación i2Cat, encargó al grupo de investigación de banda ancha del departamento de ingeniería telemática. Este trabajo se encuentra inclui...

  20. Vulnerabilidad en la cuenca alta del rio Lerma

    OpenAIRE

    Cedeño Valdiviezo, Alberto; Torres Lima, Pablo

    2013-01-01

    La subcuenca Alta del Río Lerma en el Estado de México, importante abastecedor de agua para la Ciudad de México, ha estado expuesta a una fuerte contaminación en los últimos años, misma que ha tenido como consecuencia el Cambio Climático y los consecuentes problemas de salud pública que se están manifestando de diferentes maneras. No obstante, el Estado Mexicano insiste en seguir apoyando a empresas trasnacionales asociadas al cultivo de transgénicos, producción de plaguicidas, pesticidas y P...

  1. Sistemi di alimentazione della rete Alta Val Tiberina

    OpenAIRE

    Cattaneo, M.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; D'Alema, E.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Milano-Pavia, Milano, Italia; Frapiccini, M.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Marzorati, S.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Milano-Pavia, Milano, Italia; Monachesi, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia

    2011-01-01

    Nell’ambito del progetto FIRB-Airplane [“Piattaforma di ricerca multidisciplinare su terremoti e vulcani”, fondi MIUR 2007-2011 responsabili: Cocco, Amato e Stucchi1] dalla seconda metà del 2009 è stata installata una rete densa di stazioni sismiche nell’area dell’Alta Val Tiberina (AVT, Figura 1), i cui dati in continuo vengono trasmessi alla sede di Ancona del CNT attraverso una dorsale Wi-Fi HYPERLAN [Monachesi e Cattaneo, 2010]. La rete è stata progettata cer...

  2. Matrices estructuradas y alta precisión relativa

    OpenAIRE

    Barreras Peral, Álvaro; Peña Ferrández, Juan Manuel

    2014-01-01

    Esta memoria se enmarca, dentro del Algebra Lineal Numérica, en el campo de estudio de métodos numéricos adaptados a clases de matrices con estructura especial, que es un campo que muestra una intensa y creciente actividad investigadora. Concretamente, considerará clases de matrices para las que se encontrarán métodos numéricos cuyo cálculo se podrá llevar a cabo con alta precisión relativa. Conseguir cálculos precisos es una propiedad muy deseable para cualquier método numérico. El ideal es ...

  3. Proyecto de Historia como respuesta educativa a las altas capacidades

    OpenAIRE

    Miguel Yoldi, Yohanna

    2014-01-01

    Este trabajo presenta una propuesta de intervención en el aula que responde a las necesidades educativas del alumnado con altas capacidades, desde una escuela inclusiva. Para realizarlo, nos hemos basado en dos autores: Roger J. Sternberg y Joseph S. Renzulli, que no sólo definen las características y necesidades educativas de este colectivo, sino que también proponen posibles respuestas que respondan a su forma de aprender. Desde el área de Ciencias Sociales, apostamos por el aprendizaje bas...

  4. Todos iguales, todos diferentes. Altas capacidades en el aula.

    OpenAIRE

    Soloaga Martín, Beatriz

    2012-01-01

    El presente trabajo se centra en el alumnado de altas capacidades y las posibilidades de atención en el marco del modelo de escuela inclusiva. Se comienza explicando las características de estos alumnos, los estereotipos que existen sobre ellos y las disincronías que es frecuente encontrar en su desarrollo. Se sigue la clasificación de varios autores para distinguir entre superdotación y talento viendo las diferencias significativas que existen entre ellos. De forma breve se ha...

  5. Comparison of vegetarian diets and omnivorous diets on plasma level of HDL-c: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Zili Zhang

    Full Text Available Low plasma level of high density lipoprotein cholesterol (HDL-c was an independent risk factor for cardio vascular disorder, and associated with poor outcomes in pulmonary arterial hypertension. To compare the effects of vegetarian diets and omnivorous diets on HDL-c in plasma, we identified cross-sectional and cohort studies related to HDL-c listed on PubMed and ISI Web of Knowledge as well as the corresponding references (until Nov, 2013. Twelve studies with a total of 4177 individuals were selected for meta-analysis. This meta-analysis indicates that vegetarian diets did not alter plasma HDL-c concentrations, as it wasn't initially expected by the authors [Standardized Mean Difference (SMD = 0.02 mmol/l; 95% confidence interval (CI: -0.19 to 0.22 mmol/l]. In Asia and Latin America countries, no significant differences in HDL-c levels between vegetarians and omnivores were found (SMD = -0.09 mmol/l; 95% CI: -0.43 to 0.25 mmol/l. In Europe and North America countries, the plasma level of HDL-c was also not different between the two diets (SMD = 0.09 mmol/l; 95% CI: -0.19 to 0.36 mmol/l. In light of this meta-analysis, we conclude that there is no evidence that plasma HDL-c levels differs in vegetarians and omnivores, even after adjusting for cultural circumstances.

  6. Very low levels of HDL cholesterol and atherosclerosis, a variable relationship – a review of LCAT deficiency

    Directory of Open Access Journals (Sweden)

    Savel J

    2012-06-01

    Full Text Available Julia Savel,1,2 Marianne Lafitte,1 Yann Pucheu,1,3 Vincent Pradeau,1 Antoine Tabarin,2,3 Thierry Couffinhal1,3,41Centre d'Exploration, de Prévention et de Traitement de l'Athérosclérose, Hôpital Cardiologique, 2Service d'endocrinologie, CHU Bordeaux, Université Bordeaux Segalen, Bordeaux, France; 3Université de Bordeaux Adaptation cardiovasculaire à l'ischémie, 4INSERM, Adaptation cardiovasculaire à l'ischémie, U1034, Pessac, FranceAbstract: A number of epidemiological and clinical studies have demonstrated that plasma high-density lipoprotein (HDL level is a strong inverse predictor of cardiovascular events. HDL is believed to retard the formation of atherosclerotic lesions by removing excess cholesterol from cells and preventing endothelial dysfunction. Lecithin cholesterol acyltransferase (LCAT plays a central role in the formation and maturation of HDL, and in the intravascular stage of reverse cholesterol transport: a major mechanism by which HDL modulates the development and progression of atherosclerosis. A defect in LCAT function would be expected to enhance atherosclerosis, by interfering with the reverse cholesterol transport step. As such, one would expect to find more atherosclerosis and cardiovascular events in LCAT-deficient patients. But this relationship is not always evident. In this review, we describe contradictory reports in the literature about cardiovascular risks in this patient population. We discuss the paradoxical finding of severe HDL deficiency and an absence of subclinical atherosclerosis in LCAT-deficient patients, which has been used to reject the hypothesis that HDL level is important in the protection against atherosclerosis. Furthermore, to illustrate this paradoxical finding, we present a case study of one patient, referred for evaluation of global cardiovascular risk in the presence of a low HDL cholesterol level, who was diagnosed with LCAT gene mutations.Keywords: atherosclerosis, LCAT function

  7. Alta parasitemia pelo Trypanosoma cruzi em paciente com lupus eritematoso sistêmico

    OpenAIRE

    Santos-Neto Leopoldo Luiz dos; Polcheira Máira F.; Castro Cleudson; Lima Rodrigo Aires Corrêa; Simaan César Kozak; Corrêa-Lima Francisco Aires

    2003-01-01

    É descrito um caso de doença de Chagas com alta parasitemia pelo Trypanosoma cruzi em paciente com lupus eritematoso sistêmico. O xenodiagnóstico foi útil na identificação da parasitemia e o benznidazol foi capaz de reduzir a alta e incomum parasitemia. Em indivíduos com doenças auto-imunes e immunossuprimidos, o benznidazol pode ser uma alternativa no controle da alta parasitemia por Trypanosoma cruzi.

  8. Temporal Stability of the Velodyne HDL-64E S2 Scanner for High Accuracy Scanning Applications

    Directory of Open Access Journals (Sweden)

    Craig Glennie

    2011-03-01

    Full Text Available The temporal stability and static calibration and analysis of the Velodyne HDL‑64E S2 scanning LiDAR system is discussed and analyzed. The mathematical model for measurements for the HDL-64E S2 scanner is updated to include misalignments between the angular encoder and scanner axis of rotation, which are found to be a marginally significant source of error. It is reported that the horizontal and vertical laser offsets cannot reliably be obtained with the current calibration model due to their high correlation with the horizontal and vertical offsets. By analyzing observations from two separate HDL-64E S2 scanners it was found that the temporal stability of the horizontal angle offset is near the quantization level of the encoder, but the vertical angular offset, distance offset and distance scale are slightly larger than expected. This is felt to be due to long term variations in the scanner range, whose root cause is as of yet unidentified. Nevertheless, a temporally averaged calibration dataset for each of the scanners resulted in a 25% improvement in the 3D planar misclosure residual RMSE over the standard factory calibration model.

  9. Beyond LDL-Cholesterol: New Treatments Raising HDL-Cholesterol or Enhancing Reverse Cholesterol Transport

    Directory of Open Access Journals (Sweden)

    Kostner K

    2002-01-01

    Full Text Available Neue Therapiekonzepte zur Beeinflussung der HDL. Atheroskleroseassoziierte Erkrankungen sind weltweit immer noch die Todesursache Nummer 1. Heute stehen uns eine Reihe von Therapiemöglichkeiten, wie Diät, Statine oder LDL-Apherese, zur Verfügung, welche zu einer signifikanten LDL-Reduktion führen. Trotz exzellenter Risikoreduktion sowohl in der Primär- als auch in der Sekundärprävention, sind kardiovaskuläre Mortalität und Morbidität nach wie vor eine große Herausforderung für Ärzte und unser Gesundheitssystem. Deshalb besteht ein klarer Bedarf an neuen Interventionsmöglichkeiten. High Density Lipoproteine sind ein möglicher Ansatzpunkt, und deshalb möchte ich in diesem Reviewartikel alte und neue Strategien zur Erhöhung von HDL beleuchten und 2 neue Therapieansätze, die zur Zeit klinisch getestet werden, vorstellen.

  10. Densidades de siembra de dos variedades comerciales de crisantemo, Chrysantemum morifolium Ramat en Piendamo (Cauca

    Directory of Open Access Journals (Sweden)

    Posada D. Adolfo

    1986-09-01

    Full Text Available The behavior and agricultural characteristics of two kinds of Chrysanthemum (White Marble and Yellow Polaris were evaluated in terms of yield and quality of the product. Two different kinds of planting systems were applied (single stem and pinched stem. The experimental design in randomized whole blocks for each variety and system including four density treatments (80, 90, 110 and 115 sterns per 1.05 m2 was repeated six times. The experimental unit was of 2.10 m2; 1.26 m2 were harvested. A strong discrepancy between the quantity and quality of the product was observed. The highest yields were obtained with densities of 110 and 115 stems per 1.05 m2. However, the experimental units dis not always met both requirements of a diameter greater than seven cm and three or more marketable flowers per stem. If maximizing production of acceptable bunches is taken as a decision variable, a density of 90 sterns per 1.05 m2 with a 3/3/2/2/2/3/3 arrangement with pinched stern for Yellow Polar is seems a better alternative. As for White Marble, it would be better to have 80 stems per 1.05 m2 with a 3/2/2/2/2/2/3 arrangement in the single stem, but the probability of acceptance is only 0.666. In addition, White Marble showed more susceptibility to dwarfism.Se evaluó el comportamiento y características agronómicas asociadas con el rendimiento y la calidad del producto en las variedades White Marble y Yellow Polaris, en los sistemas de tallo único y tallo despuntado. El diseño experimental de bloques completos al azar para cada variedad y sistema incluía cuatro tratamientos de densidad (80, 90, 110 Y 115 tallos por 1.05 m2, con seis repeticiones. La unidad experimental fue de 2.10 m2, cosechando 1. 26m2(1.05 x 1.20. Se observó marcado antagonismo entre la cantidad y la calidad del producto comercial. Los mayores rendimientos se obtuvieron con densidades de 110 y 115 tallos por 1.05 m2, pero no siempre la producción cumplía con los requisitos de di

  11. Importância da HDL-c para a ocorrência de doença cardiovascular no idoso La importancia del HDL-c para la ocurrencia de la enfermedad cardiovascular en el adulto mayor Importance of HDL-c for the occurrence of cardiovascular disease in the elderly

    Directory of Open Access Journals (Sweden)

    Elizabete Viana de Freitas

    2009-09-01

    Full Text Available FUNDAMENTO: Estudos sobre o impacto da HDL-c e ocorrência de doença cardiovascular (CV em idosos são escassos. OBJETIVO: Avaliar as variáveis clínicas e laboratoriais e a ocorrência de eventos CV em idosos estratificados de acordo com o comportamento da HDL-c em seguimento de oito anos. MÉTODOS: Foram avaliados, em dois momentos (A1 e A2, com espaço mínimo de cinco anos, 81 idosos, com idade média de 68,51 ± 6,32 (38,2% do sexo masculino. Os indivíduos foram divididos em 3 grupos de acordo com o nível da HDL-c: HDL-c normal nas duas avaliações (GN (n=31; HDL-c baixa nas duas avaliações (GB (n=21; e HDL-c variável de A1 para A2 (GV (n=29. Foram registrados os eventos CV maiores: doença coronariana (angina, infarto miocárdio, revascularização miocárdica percutânea/cirúrgica, acidente vascular encefálico, acidente isquêmico transitório, doença carotídea, demência e insuficiência cardíaca. RESULTADOS: Os grupos não diferiram quanto à idade e sexo em A1 e A2. As médias dos triglicérides foram menores no GN em A1 (p=0,027 e A2 (p=0,016 que no GB. Já a distribuição de eventos CV foi de 13 eventos no GN (41,9%, 16 (76,2% no GB e de 12 (41,4% no GV (χ2=7,149, p=0,024. Em análise de regressão logística observou-se que quanto maior a idade (OR=1,187, p=0,0230 e quanto menor a HDL-c (OR=0,9372, p=0,0102, maior a ocorrência de eventos CV. CONCLUSÃO: O HDL-c permanentemente baixo ao longo de oito anos de acompanhamento foi fator de risco para desenvolvimento de eventos CV em idosos.FUNDAMENTO: Estudios sobre el impacto del HDL-c y ocurrencia de enfermedad cardiovascular (CV en adultos mayores son raros. OBJETIVO: Evaluar las variables clínicas y laboratoriales y la ocurrencia de eventos CV en adultos mayores estratificados según el comportamiento del HDL-c en seguimiento de ocho años. MÉTODOS: Se evaluaron, en dos momentos (A1 y A2, con espacio mínimo de cinco años, a 81 adultos mayores, con edad promedio de

  12. Estudio de la densidad y de la viscosidad de algunos ácidos grasos puros

    Directory of Open Access Journals (Sweden)

    Cedeño González, Fidel Oscar

    1999-10-01

    Full Text Available An experimental study is carried out according to ASTM analysis methods of two physical properties, density and viscosity, of palmitic, stearic and oleic fatty acids; compounds which are present in the deodorization effluents of edible oils, with a view to their physics chemical characterisation needed for the design of surface condensers and freezers that could be employed in the recovery of these effluents. The measures are carried out every 5 °C, from temperatures close to those of solidification in each compound, of great interest in our study, to 100 °C. The values of these properties are contrasted with those that appear in the literature, and the experimental measures are correlated. Values of the density are also obtained applying Rackett's equation and those of dynamic viscosity using Andrade's equation, and then compared with experimental measures. Experimental data of the dynamic viscosity for oleic acid at low temperatures (between 0 and 24 °C are also presented, because of their interest in the design of the previously mentioned equipment.

    En este trabajo se realiza un estudio experimental de acuerdo con los métodos de análisis de la ASTM de las propiedades físicas, densidad y viscosidad en los ácidos grasos palmítico, esteárico y oleico; compuestos que están presentes en los efluentes de la desodorización de aceites comestibles, con vistas a la caracterización físico química necesaria en el diseño de condensadores y congeladores de superficie que pueden aplicarse a la recuperación de estos efluentes. Las medidas se realizan de 5 en 5 °C entre temperaturas muy próximas a las de solidificación en cada compuesto, de gran interés en nuestro estudio, y los 100 °C. Se contrastan los valores de estas propiedades, con los que aparecen en la literatura y se correlacionan las medidas experimentales. También se obtienen valores de la densidad aplicando la ecuación de Rackett y de la viscosidad din

  13. Resultados da conjuntivodacriocistorrinostomia com implante de prótese lacrimal de polietileno de baixa densidade

    Directory of Open Access Journals (Sweden)

    Bison Simone

    2002-01-01

    Full Text Available Objetivos: Estabelecer quais são as complicações pós-operatórias da conjuntivodacriocistorrinostomia (CDCR com implante de prótese lacrimal de polietileno de baixa densidade e relacionar a etiologia da obstrução e o aparecimento destas complicações e, conseqüentemente, o sucesso pós-operatório. Métodos: Foram analisadas 35 vias lacrimais submetidas a conjuntivodacriocistorrinostomia com implante de prótese lacrimal de polietileno. Com a finalidade de estudar as possíveis relações entre as variáveis encontradas (etiologia x complicações e etiologia x sucesso realizou-se o teste exato de Fisher. Resultados: As etiologias de obstrução mais freqüentes foram a dacriocistite crônica e pós-dacriocistorrinostomia que, em conjunto, foram responsáveis por 53,9% dos casos. Os traumatismos ocasionaram 16,3% das obstruções. A taxa de complicações encontrada foi 74,3%. A conjuntivodacriocistorrinostomia apresentou sucesso em uma única intervenção cirúrgica em 9 vias lacrimais (25,7%. Após duas ou mais intervenções cirúrgicas, 17 próteses lacrimais tornaram-se pérvias e bem localizadas (48,6%. O insucesso ocorreu em 9 vias lacrimais (25,7%. Não houve relação estatisticamente significante entre etiologia e ocorrência de complicações nem entre etiologia e sucesso pós-operatório. Conclusões: As complicações encontradas são similares às descritas na literatura e não tiveram relação com a etiologia da obstrução canalicular. O mesmo pode ser considerado no que se refere ao sucesso da conjuntivodacriocistorrinostomia. As vantagens da prótese lacrimal de polietileno de baixa densidade são a grande disponibilidade, a fácil confecção no per-operatório de acordo com o comprimento e o diâmetro do colarete desejados e pode ser substituída pela prótese lacrimal de vidro de borosilicato assim que o edema regrida.

  14. Non-HDL-cholesterol as valid surrogate to apolipoprotein B100 measurement in diabetes: Discriminant Ratio and unbiased equivalence

    Directory of Open Access Journals (Sweden)

    Ahn Sylvie A

    2011-02-01

    Full Text Available Abstract Background Apolipoprotein B100 (apoB is a superior indicator of CV risk than total or LDL-C. Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high correlation, although the degree of mutual concordance remains debated in CV risk evaluation. Objectives We used the Discriminant Ratio (DR methodology to compare the performance of non-HDL-C with that of apoB to rank diabetic patients according to dyslipidemia and to establish the underlying relationship between these variables taking measurement noise and intra-/intersubject variation into account, and to derive an unbiased equivalence equation. Methods Fasting total C, HDL-C, apoB and triglycerides were measured in 45 diabetic patients. The DR of the underlying between-subject standard deviation (SD to the within-subject SD was calculated from duplicates. Correlation coefficients between pairs were adjusted to include an estimate of the underlying correlation. Results Mean values [day 1 (1SD] were 143 (36 mg/dl (non-HDL-C and 98 (24 mg/dl (apoB. The DR's of both parameters were similar (1.76 and 1.83 (p = 0.83. Pearson's product-moment correlation coefficient between tests was very high (0.94, reaching unity (1.00 after attenuation adjustment. The unbiased equation of equivalence relating apoB to non-HDL-C had a slope of 0.65 and an intercept of 6.3 mg/dl. Conclusions The discrimination power of non-HDL-C is similar to that of apoB to rank diabetic patients according to atherogenic cholesterol and lipoprotein burden. Since true correlation between variables reached unity, non-HDL-C may provide not only a metabolic surrogate but also a candidate biometrical equivalent to apoB, as non-HDL-C calculation is readily available.

  15. Performance of juvenile turbot (Scophthalmus maximus fed varying dietary L-carnitine levels at different stocking densities Desempenho de juvenis de pregado (Scophthalmus maximus em função da densidade de estocagem e de níveis dietéticos de L-carnitina

    Directory of Open Access Journals (Sweden)

    José Fernando Magalhães Gonçalves

    2010-04-01

    (75,6 ± 2,8 g alimentados durante 75 dias a dois níveis dietéticos de L-carnitina (40 ou 240 mg kg¹. Após esse período, determinou-se a excreção de amônia pós-prandial durante 24 horas. Os peixes cultivados na menor densidade, 4 kg m², apresentaram melhores taxas de crescimento e ganho de peso (94-96 g em comparação aos mantidos em altas densidades (80-87 g. A taxa de eficiência proteica foi mais elevada a 4 kg m² (1,33-1,36, do que a densidades de 8 kg m² (0,98 ou 14 kg m² (0,45. A ingestão voluntária de alimento decresceu de 0,70 para 0,56% do peso corporal com o incremento da densidade. A suplementação de carnitina não afetou o crescimento e a composição corporal, com exceção do conteúdo de carnitine da carcaça que passou de 75 a 128 mg kg¹. Peixes alimentados com suplementos de 240 mg L-carnitina apresentam excreção de amônia mais baixa comparativamente aos alimentados com 40 mg L-carnitina (p < 0,05.

  16. Photophysical characterization of anticancer drug valrubicin in rHDL nanoparticles and its use as an imaging agent.

    Science.gov (United States)

    Shah, Sunil; Chib, Rahul; Raut, Sangram; Bermudez, Jaclyn; Sabnis, Nirupama; Duggal, Divya; Kimball, Joseph D; Lacko, Andras G; Gryczynski, Zygmunt; Gryczynski, Ignacy

    2016-02-01

    Nanoparticles are target-specific drug delivery agents that are increasingly used in cancer therapy to enhance bioavailability and to reduce off target toxicity of anti-cancer agents. Valrubicin is an anti-cancer drug, currently approved only for vesicular bladder cancer treatment because of its poor water solubility. On the other hand, valrubicin carrying reconstituted high density lipoprotein (rHDL) nanoparticles appear ideally suited for extended applications, including systemic cancer chemotherapy. We determined selected fluorescence properties of the free (unencapsulated) drug vs. valrubicin incorporated into rHDL nanoparticles. We have found that upon encapsulation into rHDL nanoparticles the quantum yield of valrubicin fluorescence increased six fold while its fluorescence lifetime increased about 2 fold. Accordingly, these and potassium iodide (KI) quenching data suggest that upon incorporation, valrubicin is localized deep in the interior of the nanoparticle, inside the lipid matrix. Fluorescence anisotropy of the rHDL valrubicin nanoparticles was also found to be high along with extended rotational correlation time. The fluorescence of valrubicin could also be utilized to assess its distribution upon delivery to prostate cancer (PC3) cells. Overall the fluorescence properties of the rHDL: valrubicin complex reveal valuable novel characteristics of this drug delivery vehicle that may be particularly applicable when used in systemic (intravenous) therapy. PMID:26735001

  17. The Effects of Sino - implant Containing LNG on Lipoprotein Metabolism and Changes in Blood HDL2-C Levels

    Institute of Scientific and Technical Information of China (English)

    杨培娟; 吴学浙; 杨秋英; 蔡红珍; 李慧沁

    1999-01-01

    The effects of the domestically manufactured contraceptive, Sino-implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL2-C levels were evaluated in 20 healthy reproductive-aged volunteers, during cycles after implantation. Results show that the levels of lipids, lipoproteins and apolipoproteins were reduced to different degrees during the 12 treatment cycles. A significant decrease was observed in the serum levels of triglycerides (TG, P~ O. 05) and apolipoprotein A I(apo A I , P<0. 05) during treatment cycles. However these values increased again at the end of the 12th cycle. High density lipoprotein 2-cholesterel (HDL2) decreased significantly (P<0. 05), only during the 8rd and 12th cycle. These results indicate that Sino-implants containing LNG exerts an influence on reducing the levels of TG,apo A I and HDL,, but those values could return gradually as the released drug dose decreased and then became unchanged. On the other hand, the mechanism of the low HDL2-C level induced by Sino-implant is different from that of low HDL2-C level in patients with coronary heart disease. The conclusion is: there is no obvious side effect on lipid metabolism during treatment with the Sino-implant.

  18. Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage.

    Science.gov (United States)

    Berrougui, Hicham; Isabelle, Maxim; Cherki, Mounia; Khalil, Abdelouahed

    2006-12-14

    The objective of the present study was to elucidate the beneficial properties of aqueous extracts of Marrubium vulgare (AEM) towards cardiovascular disease by protecting human-LDL against lipid peroxidation and promoting HDL-mediated cholesterol efflux. Human-LDL were oxidised by incubation with CuSO(4) in the presence of increased concentrations of AEM (0-100 microg/ml). LDL lipid peroxidation was evaluated by conjugated diene formation, vitamin E disappearance as well as LDL-electrophoretic mobility. HDL-mediated cholesterol efflux assay was carried out in human THP-1 macrophages. Incubation of LDL with AEM significantly prolonged the lag phase (P=0.014), lowered the progression rate of lipid peroxidation (P=0.004), reduced the disappearance of vitamin E and the electrophoretic mobility in a dose-dependent manner. Also, incubation of HDL with AEM significantly increased HDL-mediated cholesterol efflux from THP-1 macrophages implicating an independent ATP binding cassette A1 (ABCA1) pathways. Our findings suggest that M. vulgare provides a source of natural antioxidants, which inhibit LDL oxidation and enhance reverse cholesterol transport and thus can prevent cardiovascular diseases development. These antioxidant properties increase the anti-atherogenic potential of HDL. PMID:17045616

  19. Caracterización de las densidades en autómatas celulares binarios unidimensionales con retardo

    Directory of Open Access Journals (Sweden)

    José Manuel Gómez Soto

    2010-01-01

    La caracterización de la densidad en estos autómatas celulares es importante ya que las transmisiones de señales con retardo están en muchos sistemas de la naturaleza. Entre ellos se encuentra la regularización del gen, las neuronas cerebrales y las señales en cascada en organismos multicelulares. Determinar entonces el comportamiento de la densidad en estos modelos nos dirá más acerca del fenómeno que se simula con ellos y acerca del modelo mismo, obtendremos más información sobre que tan robusto es el espacio temporal, cómo cambia su dinámica y cómo se afecta su capacidad de procesamiento de información.

  20. DENSIDAD Y DISTRIBUCIÓN SOBRE CSMA/CA EN REDES IEEE 802.11G EN MODO AD HOC

    OpenAIRE

    José Domínguez

    2009-01-01

    El propósito principal de la presente investigación, fue determinar la influencia de la densidad y distribución de hosts sobre el control de acceso al medio en redes IEEE 802.11g, tomando como variables fundamentales la densidad y distribución de los mismos y el protocolo CSMA/CA para el acceso al medio de transmisión. La investigación fue de tipo explicativa, con un diseño experimental puro. La misma se basó en los postulados teóricos de Bates (2003), Comer (2000), León García (2001), Sta...

  1. EVALUACIÓN DE DENSIDADES DE PLANTACIÓN EN EL CULTIVO DE LA JAMAICA (Hibiscus sabdariffa L.

    Directory of Open Access Journals (Sweden)

    Z. Terán

    2004-01-01

    Full Text Available La investigación se llevó a cabo en el Instituto Nacional de Ciencias Agrícolas (INCA, en el verano del 2001, con el objetivo de comparar seis distancias de plantación en el cultivo de la Jamaica ( Hibiscus sabdariffa L. y su influencia en los rendimientos y sus componentes por superficie para definir la densidad óptima. Las distancias empleadas fueron: 1.20x1.00m; 1.20x0.90m; 1.00x1.00m; 1.00x0.90m; 0.90x0.90m y 0.90x0.80m; a esos marcos de plantación correspondieron las siguientes densidades: 8 333, 9 260, 10 000, 11 111, 12 345 y 13 888 plantas.ha -1 . Se utilizó un diseño de bloques al azar con cuatro repeticiones. Se evaluaron el peso de frutos más el cáliz fresco y seco por separado. Los datos se procesaron mediante un Análisis de Varianza de Clasificación Simple, encontrándose di- ferencias significativas entre los tratamientos. Los resultados mostraron que los rendimientos se comportaron en correspon- dencia con las densidades de plantación, obteniéndose 7.53 t.ha -1 de cálices frescos en la mayor densidad y 4.5 t.ha -1 en la menor.

  2. Densidad poblacional del venado cola blanca (Odocoileus virginianus en sabana inindable de Paz De Ariporo (Casanare, Orinoquia colombiana

    Directory of Open Access Journals (Sweden)

    Montenegro Olga Lucía

    2006-12-01

    Full Text Available Esta investigación buscó estimar y analizar las diferencias en la densidad poblacional del venado cola blanca
    (Odocoileus virginianus en dos hatos de la Orinoquia colombiana, con miras a aportar elementos para su manejo
    sostenible en la región. Para la estimación de densidad se realizaron conteos de individuos y grupos en transectos
    lineales de ancho variable acumulando 54,3 km y 48,65 km en los hatos Taparas y Miramar respectivamente.
    Estos recorridos se realizaron entre junio y julio de 2005, que corresponde a la época de lluvias. La densidad tanto
    de individuos como de grupos de venados fue mayor en el hato Taparas (0,44 venados/ha y 0,148 grupos/ha
    respectivamente que en el hato Miramar (0,11 venados/ha y 0,086 grupos/ha respectivamente. El número de hembras observadas fue mayor que el número de machos tanto en el hato Taparas (c2=165,8, p <0,05 como en el hato Miramar (c2=18, p <0,05. En los dos hatos la distribución de edades se caracterizó por una mayor proporción de adultos seguido por juveniles y crías. En el hato Taparas el tamaño promedio de grupo fue de 3,01, mientras en el hato Miramar éste fue de 1,55 individuos. Se discuten las diferencias en densidad en los dos hatos a la luz de presiones de cacería, variaciones en el hábitat e interacciones con el ganado vacuno de la zona.

  3. Medida de densidades con el picnómetro y de tensión superficial con el estalagmómetro

    OpenAIRE

    Espinosa Tomás, Julián; Pérez Rodríguez, Jorge; Miret Marí, Juan José; Caballero Caballero, María Teresa

    2010-01-01

    Guión de la práctica de Física de primero de grado de Óptica y Optometría "MEDIDA DE DENSIDADES CON EL PICNÓMETRO Y DE TENSIÓN SUPERFICIAL CON EL ESTALAGMÓMETRO" Objetivos: Medir densidades de sólidos y líquidos. Medir la tensión superficial de un líquido problema con el estalagmómetro.

  4. Non-leaky vesiculation of large unilamellar vesicles (LUV) induced by plasma high density lipoproteins (HDL): Detection by HPLC

    International Nuclear Information System (INIS)

    Interaction of large unilamellar phosphatidylcholine vesicles (LUV, 75nm) and plasma high density lipoproteins (HDL) resulted in a non-leaky vesiculation of LUV. This vesiculation was detected by a HPLC-system consisting of a combination of three TSK-gel columns (6000PW, 5000PW, 3000SW). With increasing incubation time liposomal [14C]PC, entrapped [3H]inulin, and apoprotein of HDL origin decreased. The decrease was accompanied by a formation of new particles, consisting of liposomal PC and apoprotein. These particles also enclosed [3H]inulin, reflecting a hydrophilic inner space. The formation of the particles reached a maximum after one day of incubation. Retention time was 21 minutes for LUV, 28 minutes for the new particles, and 36 minutes for HDL. In vesicles with membranes consisting of phosphatidylcholine and 30% cholesterol no interactions were observed

  5. Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels

    DEFF Research Database (Denmark)

    Haase, C L; Frikke-Schmidt, R; Nordestgaard, B G;

    2011-01-01

    levels. Mutations in apolipoprotein (apo) A-I, the major protein constituent of HDL, might be associated with low HDL cholesterol and predispose to IHD and early death. DESIGN: We resequenced APOA1 in 190 individuals and examined the effect of mutations on HDL cholesterol, risk of IHD, myocardial...... infarction (MI) and mortality in 10 440 individuals in the prospective Copenhagen City Heart Study followed for 31 years. Results were validated in an independent case-control study (n = 16 035). Additionally, we determined plasma ratios of mutant to wildtype (WT) apoA-I in human heterozygotes and functional.......3-4.8), respectively, in heterozygotes compared with noncarriers. Mean reduction in survival time in heterozygotes was 10 years (P < 0.0001). Results for IHD and MI were confirmed in the case-control study. Furthermore, the ratio of mutant S164 to WT A164 apoA-I in plasma of heterozygotes was reduced. In addition, A...

  6. Aclimatação de mudas de acariquara à alta irradiância Acclimation of manwood seedlings to full sunlight

    Directory of Open Access Journals (Sweden)

    Nilvanda dos Santos Magalhães

    2009-07-01

    Full Text Available O objetivo deste trabalho foi determinar as mudanças fisiológicas que ocorrem em acariquara (Minquartia guianensis durante o processo de aclimatação à alta irradiância, bem como a estratégia de aclimatação dessa espécie. Plantas mantidas em baixa irradiância foram transferidas para alta irradiância por 290 dias. Durante esse período, foi medida a relação entre fluorescência variável e máxima (Fv/Fm, em folhas desenvolvidas à sombra e, após a senescência prematura por foto-oxidação, em folhas aclimatadas ao sol. Ao final do experimento, foram determinadas as características fotossintéticas e anatômicas da folha. A exposição à alta irradiância causou, logo após a transferência, forte fotoinibição e foto-oxidação parcial da folhagem, mas não provocou a morte da planta. Folhas produzidas no ambiente ensolarado apresentaram valores de Fv/Fm similares aos do controle. A fotossíntese saturada por luz e a fotossíntese saturada por CO2 foram 90 e 50% maiores em plantas aclimatadas à alta irradiância. A velocidade máxima de carboxilação da rubisco e a taxa máxima de regeneração da ribulose bisfosfato seguiram a mesma tendência. Folhas produzidas ao sol apresentaram maior densidade estomática e maior espessura foliar. A produção de folhas novas é a principal estratégia de aclimatação da acariquara à alta irradiância.The aim of this work was to determine the physiological changes that occur in manwood (Minquartia guianensis during the acclimation process to high irradiance, and also to determine the acclimation strategy of this species. Plants kept in low light were transferred to high irradiance for 290 days. During this period the ratio between variable fluorescence and maximum fluorescence (Fv/Fm was measured in leaves developed in the shade, and after premature senescence due to photooxidation, in sun-acclimated leaves. At the end of the experimental period the anatomic and photosynthetic

  7. The human HDL proteome displays high inter-individual variability and is altered dynamically in response to angioplasty-induced atheroma plaque rupture.

    Science.gov (United States)

    Jorge, Inmaculada; Burillo, Elena; Mesa, Raquel; Baila-Rueda, Lucía; Moreno, Margoth; Trevisan-Herraz, Marco; Silla-Castro, Juan Carlos; Camafeita, Emilio; Ortega-Muñoz, Mariano; Bonzon-Kulichenko, Elena; Calvo, Isabel; Cenarro, Ana; Civeira, Fernando; Vázquez, Jesús

    2014-06-25

    Recent findings support potential roles for HDL in cardiovascular pathophysiology not related to lipid metabolism. We address whether HDL proteome is dynamically altered in atheroma plaque rupture. We used immunoaffinity purification of HDL samples from coronary artery disease patients before and after percutaneous transluminal coronary angioplasty (PTCA), a model of atheroma plaque disruption. Samples were analyzed by quantitative proteomics using stable isotope labeling and results were subjected to statistical analysis of protein variance using a novel algorithm. We observed high protein variability in HDL composition between individuals, indicating that HDL protein composition is highly patient-specific. However, intra-individual protein variances remained at low levels, confirming the reproducibility of the method used for HDL isolation and protein quantification. A systems biology analysis of HDL protein alterations induced by PTCA revealed an increase in two protein clusters that included several apolipoproteins, fibrinogen-like protein 1 and other intracellular proteins, and a decrease in antithrombin-III, annexin A1 and several immunoglobulins. Our results support the concept of HDL as dynamic platforms that donate and receive a variety of molecules and provide an improved methodology to use HDL proteome for the systematic analysis of differences among individuals and the search for cardiovascular biomarkers. Biological significance The HDL proteome is an interesting model of clinical relevance and has been previously described to be dynamically altered in response to pathophysiological conditions and cardiovascular diseases. Our study suggests that interindividual variability of HDL proteome is higher than previously thought and provided the detection of a set of proteins that changed their abundance in response to plaque rupture, supporting the concept of HDL as dynamic platforms that donate and receive a variety of molecules. PMID:24747125

  8. Material management providing best value to TransAlta Utilities

    International Nuclear Information System (INIS)

    Materials management functions at TransAlta Utilities were outlined in several overhead viewgraphs. The system includes purchasing, contracts, fleet management, inventory control and warehouses management. Various components of the system are depicted, including: (1) integrated information system, (2) materials management (MM) process flow, (3) key suppliers, (4) commodity categories, (5) performance evaluation process, (6) new ways of working with service suppliers, (7) location of staff in the field and head office, (8) contracts, (9) tracking key performance indicators, (10) blocked invoice performance, and (11) warehouse optimization and inventory control. Current initiatives are being reviewed with a view to reduce operations to a single service centre, based on the corporate objective to increase the value of MM by 20 per cent by the year 2000. 3 tabs., 4 figs

  9. MICROTOMOGRAFIA DE ALTA RESOLUÇÃO NO SETOR MINERAL

    OpenAIRE

    Daniel Uliana; Henrique Kahn; Renato Contessotto; Juliana Livi Antoniassi

    2014-01-01

    A técnica de microscopia por tomografia de raios X (MRX) oferece uma capacidade única para análise de associações, morfologia e liberação de múltiplas fases através da aquisição direta de imagens tridimensionais de alta resolução. Trata-se de uma técnica de análise 3D não invasiva atualmente utilizada no setor mineral para caracterização de carvão, minerais industriais e de base, além de metais preciosos, complementando técnicas de microscopia já existentes como MLA e QEMSCAN. A técnica já é ...

  10. Chemical characterization earthenware on the Alta California Frontier

    International Nuclear Information System (INIS)

    Throughout what was Alta California archaeological have found in Spanish and Mexican Period missions, presides, pueblos, and ranchos fragments of hand-modeled and wheel-thrown, unglazed, low fired earthenware's. the extraordinary visual similarities between earthenware's found hundreds of miles apart has been explained by some as the most of the ceramics were produced and used locally. The research presented in this paper is based on the use of neutron activation analysis to compositionally characterize the paste of a sample of these earthenware's. Samples from the missions sites of Dolores, Santa Clara, San Jose, Santa Cruz, San Antonio and San Juan Capistrano and the presiders of san Francisco, Monterey, and San Diego have been analyzed

  11. Plasma kinetics of an LDL-like nanoemulsion and lipid transfer to HDL in subjects with glucose intolerance

    Directory of Open Access Journals (Sweden)

    Marina P Bertato

    2012-01-01

    Full Text Available OBJECTIVE: Glucose intolerance is frequently associated with an altered plasma lipid profile and increased cardiovascular disease risk. Nonetheless, lipid metabolism is scarcely studied in normolipidemic glucose-intolerant patients. The aim of this study was to investigate whether important lipid metabolic parameters, such as the kinetics of LDL free and esterified cholesterol and the transfer of lipids to HDL, are altered in glucose-intolerant patients with normal plasma lipids. METHODS: Fourteen glucose-intolerant patients and 15 control patients were studied; none of the patients had cardiovascular disease manifestations, and they were paired for age, sex, race and co-morbidities. A nanoemulsion resembling a LDL lipid composition (LDE labeled with 14C-cholesteryl ester and ³H-free cholesterol was intravenously injected, and blood samples were collected over a 24-h period to determine the fractional clearance rate of the labels by compartmental analysis. The transfer of free and esterified cholesterol, triglycerides and phospholipids from the LDE to HDL was measured by the incubation of the LDE with plasma and radioactivity counting of the supernatant after chemical precipitation of non-HDL fractions. RESULTS: The levels of LDL, non-HDL and HDL cholesterol, triglycerides, apo A1 and apo B were equal in both groups. The 14C-esterified cholesterol fractional clearance rate was not different between glucose-intolerant and control patients, but the ³H-free-cholesterol fractional clearance rate was greater in glucose-intolerant patients than in control patients. The lipid transfer to HDL was equal in both groups. CONCLUSION: In these glucose-intolerant patients with normal plasma lipids, a faster removal of LDE free cholesterol was the only lipid metabolic alteration detected in our study. This finding suggests that the dissociation of free cholesterol from lipoprotein particles occurs in normolipidemic glucose intolerance and may participate in

  12. Verification and Diagnosis Infrastructure of SoC HDL-model

    CERN Document Server

    Hahanov, Vladimir; Litvinova, Eugenia; Chumachenko, Svetlana

    2012-01-01

    This article describes technology for diagnosing SoC HDL-models, based on transactional graph. Diagnosis method is focused to considerable decrease the time of fault detection and memory for storage of diagnosis matrix by means of forming ternary relations in the form of test, monitor, and functional component. The following problems are solved: creation of digital system model in the form of transaction graph and multi-tree of fault detection tables, as well as ternary matrices for activating functional components in tests, relative to the selected set of monitors; development of a method for analyzing the activation matrix to detect the faults with given depth and synthesizing logic functions for subsequent embedded hardware fault diagnosing.

  13. Anti-ATP synthase autoantibodies from patients with Alzheimer's disease reduce extracellular HDL level.

    Science.gov (United States)

    Vacirca, Davide; Barbati, Cristiana; Scazzocchio, Beatrice; Masella, Roberta; Rosano, Giuseppe; Malorni, Walter; Ortona, Elena

    2011-01-01

    Aside from being an integral protein involved in the synthesis and hydrolysis of ATP, Ecto-F1-ATPase plays a role in cholesterol homeostasis. We demonstrated the presence of autoantibodies to ecto-F1-ATPase (ASabs) in sera and cerebrospinal fluids from patients with Alzheimer's disease (AD). Herein we show that ASabs, unlike irrelevant antibodies, can increase cellular uptake of HDL, a risk factor for the development of AD, via a mechanism involving the prototypical function of ecto-F1-ATPase: the generation of ADP due to the hydrolysis of ATP. Piceatannol, a specific inhibitor ecto-F1-ATPase, completely hindered these effects. We hypothesize that ASabs could exert a pathogenetic role in AD. PMID:21677380

  14. Design and Verification of Area-Optimized AES Based on FPGA Using Verilog HDL

    Directory of Open Access Journals (Sweden)

    N. Radhika, 2Obili Ramesh, 3Priyadarshini,

    2013-09-01

    Full Text Available Advanced Encryption Standard (AES, has received significant interest over the past decade due to its performance and security level. In most of the previous works subbytes and inverse subbytes are implemented in Separate Modules using lookup table method. In this paper we used combinational logic which helps for making inner round pipelining in an efficient manner. Furthermore, composite field arithmetic helped in obtaining lesser area. Using proposed architecture, a fully sub pipelined encryptor/ decryptor with 3 substage pipelining in each round can achieve a throughput of 25.89Gbps on Xilinx xc5vlx110t-1 device which is faster. This AES design was implemented using Verilog HDL and synthesized with Xilinx ISE using Spartran3 Xilinx Family , Simulation and Verification was done using Mentor-Graphics ModelSim-6.5e and achieved the maximum through put

  15. The Importance of Serum Mucoprotein and Hdl Cholesterol ın the Diagnosis and Prognosis of Viral Hepatitis

    OpenAIRE

    KARAKELLEOĞLU, Cahit; Kalaycı, Ayhan Gazi; Yılmaz, Erdal; AKDAĞ, Recep; Ceviz, Naci

    1993-01-01

    One hundred patients 41 females and 59 males with viral hepatitis and 25 healthy children 8 females and 17 males aged 2 13 years were included in this study In patients with viral hepatitis serum mucoprotein levels were 59 5±12 8 mg dl on admission 88 3±13 3 mg dl 20 days later and 99 7±12 4 mg dl 3 months later; HDL cholesterol levels were 28 7± 3 79 mg dl on admission 35 92±4 51 mg dl 20 days later and 40 23±4 75 mg dl 3 months later In healthy children serum mucoprotein and HDL cholesterol...

  16. Effect of sterol carrier protein-2 gene ablation on HDL-mediated cholesterol efflux from cultured primary mouse hepatocytes

    OpenAIRE

    Storey, Stephen M.; Atshaves, Barbara P.; McIntosh, Avery L.; Kerstin K. Landrock; Martin, Gregory G.; Huang, Huan; Ross Payne, H.; Johnson, Jeffery D.; Macfarlane, Ronald D.; Kier, Ann B.; Schroeder, Friedhelm

    2010-01-01

    Although HDL-mediated cholesterol transport to the liver is well studied, cholesterol efflux from hepatocytes back to HDL is less well understood. Real-time imaging of efflux of 22-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-amino)-23,24-bisnor-5-cholen-3β-ol (NBD-cholesterol), which is poorly esterified, and [3H]cholesterol, which is extensively esterified, from cultured primary hepatocytes of wild-type and sterol carrier protein-2 (SCP-2) gene-ablated mice showed that 1) NBD-cholesterol efflux w...

  17. Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk

    DEFF Research Database (Denmark)

    Nordestgaard, Børge G; Tybjærg-Hansen, Anne

    2011-01-01

    To evaluate whether new and known genetic determinants of plasma levels of LDL cholesterol, lipoprotein(a), triglyceride-rich lipoproteins, and HDL cholesterol associate with the risk of cardiovascular disease expected from the effect on lipoprotein levels. Concordance or discordance of such gene...... genetic determinants with cardiovascular disease risk will either favor or disfavor that these lipoproteins are causally related to cardiovascular disease.......To evaluate whether new and known genetic determinants of plasma levels of LDL cholesterol, lipoprotein(a), triglyceride-rich lipoproteins, and HDL cholesterol associate with the risk of cardiovascular disease expected from the effect on lipoprotein levels. Concordance or discordance of such...

  18. Correlation Between Obesity and High Density Lipoprotein Cholesterol (HDL-C) in Breast Cancer Patients of Southern Rajasthan

    OpenAIRE

    Inamdar, Padmanabh; Mehta, Garima

    2011-01-01

    Despite advances in management of breast cancer, etiology is still elusive. Diet, obesity and other life style factors have been implicated in its etiology. We assessed the role of obesity and HDL-C levels in patients with rural background in etiology of breast cancer. To know the relation between obesity and incidence of breast cancer in local population. Also to know serum HDL-C level in breast cancer and its correlation with breast cancer. A nested pilot study of 50 breast cancer patients ...

  19. Isolated low high density lipoprotein-cholesterol (HDL-C: implications of global risk reduction. Case report and systematic scientific review

    Directory of Open Access Journals (Sweden)

    Tyagi Suresh C

    2005-01-01

    Full Text Available Abstract Background The importance of low high-density lipoprotein cholesterol (HDL-C, elevated non HDL-C (as part of the metabolic syndrome, prediabetes, and type 2 diabetes mellitus, and an isolated low HDL-C is rapidly emerging. The antiatherosclerotic roles of reverse cholesterol transport and the pleiotropic antioxidant – anti-inflammatory mechanistic effects of HDL-C are undergoing rapid exponential growth. Case presentation In 1997 a 53-year-old Caucasian male presented with a lipoprotein profile of many years duration with an isolated low HDL-C and uric acid levels in the upper quintile of normal. He developed an acute myocardial infarction involving the right coronary artery and had percutaneous transluminal coronary angioplasty with stenting of this lesion. He also demonstrated a non-critical non-flow limiting lesion of the proximal left anterior descending coronary artery at the time of this evaluation. Following a program of global risk reduction this patient has done well over the past 7 years and remains free of any clinical signs and symptoms of atherosclerosis. His HDL-C and uric acid levels are currently in the normal physiological range. Conclusion Low HDL-C and isolated low HDL-C constitute an important risk factor for atherosclerosis. Therapies that lead to a return to normal physiologic range of HDL-C may result in the delay of atherosclerotic progression.

  20. Estudio de las propiedades antiaterogénicas de las HDL de ratones transgénicos de apoA-II humana

    OpenAIRE

    Ribas Serra, Vicent

    2005-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada Las apolipoproteínas más abundantes de HDL son la apoA-I y la apoA-II. La concentración plasmática de apoA-I está inversamente relacionada con el riesgo de enfermedad coronaria y su papel en las HDL es bien conocido. La apoA-I tiene un papel estructural muy importante en HDL, interacciona con receptores de HDL provocando el eflujo de colesterol de membranas celulares y es cofactor de la LCAT. En cambio, el papel que jueg...

  1. The Triglyceride to HDL Ratio and Its Relationship to Insulin Resistance in Pre- and Postpubertal Children: Observation from the Wausau SCHOOL Project

    Directory of Open Access Journals (Sweden)

    Karen Olson

    2012-01-01

    Full Text Available Insulin resistance (IR is a risk factor for ischemic heart disease and diabetes and raises the triglyceride/high-density lipoprotein (TG/HDL ratio in adults, but is not well defined in children. Purpose. To investigate the TG/HDL ratios in children as an IR marker. Methods. Wausau SCHOOL Project assessed 99 prepubertal and 118 postpubertal children. The TG/HDL ratio was correlated with numerous risk factors. Results. TG/HDL ratio was significantly correlated with QUICKI, HOMA-IR, zBMI, waist-to hip ratio, systolic and diastolic BP, LDL size and LDL number. A group of 32 IR children (HOMA-IR > 1 SD from the mean, i.e., >2.45 had significantly higher TG/HDL (3.11 ± 1.77 compared to non-IR children (1.86 ± 0.75. A TG/HDL ratio of ≥2.0 identified 32 of the 40 children deemed IR by HOMA-IR (>2.45 with a sensitivity of 0.80 and a specificity of 0.66. Children with TG/HDL ratio ≥3 were heavier and had higher BP, glucose, HOMA-IR, LDL number, and lower HDL level, QUICKI, and LDL size, regardless of pubertal status. Conclusion. The TG/HDL ratio is strongly associated with IR in children, and with higher BMI, waist hip ratio, BP, and more athrogenic lipid profile.

  2. Folded Functional Lipid-Poor Apolipoprotein A-I Obtained by Heating of High-Density Lipoproteins: Relevance to HDL Biogenesis

    OpenAIRE

    Jayaraman, Shobini; Cavigiolio, Giorgio; Gursky, Olga

    2012-01-01

    High-density lipoproteins (HDL) remove cell cholesterol and protect from atherosclerosis. The major HDL protein is apolipoprotein A-I (apoA-I). Most plasma apoA-I circulates in lipoproteins, yet ~5% forms monomeric lipid-poor/free species. This metabolically active species is a primary cholesterol acceptor and is central to HDL biogenesis. Structural properties of lipid-poor apoA-I are unclear due to difficulties in isolating this transient species. We used thermal denaturation of human HDL t...

  3. 9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages

    Directory of Open Access Journals (Sweden)

    Sapir Bechor

    2016-07-01

    Full Text Available Cholesterol efflux from macrophages is a key process in reverse cholesterol transport and, therefore, might inhibit atherogenesis. 9-cis-β-carotene (9-cis-βc is a precursor for 9-cis-retinoic-acid (9-cis-RA, which regulates macrophage cholesterol efflux. Our objective was to assess whether 9-cis-βc increases macrophage cholesterol efflux and induces the expression of cholesterol transporters. Enrichment of a mouse diet with βc from the alga Dunaliella led to βc accumulation in peritoneal macrophages. 9-cis-βc increased the mRNA levels of CYP26B1, an enzyme that regulates RA cellular levels, indicating the formation of RA from βc in RAW264.7 macrophages. Furthermore, 9-cis-βc, as well as all-trans-βc, significantly increased cholesterol efflux to high-density lipoprotein (HDL by 50% in RAW264.7 macrophages. Likewise, food fortification with 9-cis-βc augmented cholesterol efflux from macrophages ex vivo. 9-cis-βc increased both the mRNA and protein levels of ABCA1 and apolipoprotein E (APOE and the mRNA level of ABCG1. Our study shows, for the first time, that 9-cis-βc from the diet accumulates in peritoneal macrophages and increases cholesterol efflux to HDL. These effects might be ascribed to transcriptional induction of ABCA1, ABCG1, and APOE. These results highlight the beneficial effect of βc in inhibition of atherosclerosis by improving cholesterol efflux from macrophages.

  4. Densidades de plantio na produtividade e qualidade de frutos de melancia

    Directory of Open Access Journals (Sweden)

    Anamaria RP Ramos

    2009-12-01

    Full Text Available O experimento foi conduzido na Embrapa Semi-Árido em Petrolina-PE, de setembro a dezembro de 2007, para avaliar o desempenho agronômico e a qualidade dos frutos de melancia cultivadas sob diferentes densidades de plantio. Foram avaliados três espaçamentos combinados com seis cultivares de melancia, sendo duas diplóides de polpa amarela (BRS Soleil e BRS Kuarah, duas triplóides (Híbrido Triplóide CPATSA e Extasy Seedless e duas cultivares comerciais, também diploídes e de fruto pequeno (Smile e Sugar Baby. O delineamento experimental utilizado foi em blocos ao acaso, com esquema fatorial em três repetições. Os tratamentos resultaram da combinação de três espaçamentos (2,0 x 0,3 m; 2,0 x 0,4 m e 2,0 x 0,5 m e seis cultivares de melancia. Foram realizadas duas colheitas, para o Hibrido Triplóide CPATSA e Extasy Seedless, aos 68 DAP (dias após o plantio e 82 DAP. O primeiro e o segundo "corte", respectivamente, para as outras cultivares aconteceram aos 63 DAP e 77 DAP. Avaliaram-se a massa fresca da parte aérea (g, massa média de frutos (g, produção comercial e refugo (g,; diâmetro do fruto (cm, comprimento do fruto (cm, espessura de casca (cm, teor de sólidos solúveis (SS, acidez titulável (AT, relação SS/AT e firmeza da polpa. As análises de variância foram realizadas usando-se o teste F e as médias comparadas através do teste de Tukey ao nível de 5% de probabilidade. De modo geral, os espaçamentos não afetaram a qualidade dos frutos, de modo que o aumento da densidade de plantas permitiu a obtenção de maior produtividade.The experiment was carried out in Petrolina, Pernambuco State, Brazil, from September to December 2007, to evaluate the agronomic performance and fruit quality of watermelon cultivated under different planting densities. Three planting spaces and six cultivars were evaluated, where two cultivars were of yellow pulp (BRS Soleil and BRS Kuarah, two cultivars were triploid (Triploid Hybrid

  5. A Single In-Vial Dual Extraction Strategy for the Simultaneous Lipidomics and Proteomics Analysis of HDL and LDL Fractions.

    Science.gov (United States)

    Godzien, Joanna; Ciborowski, Michal; Armitage, Emily Grace; Jorge, Inmaculada; Camafeita, Emilio; Burillo, Elena; Martín-Ventura, Jose Luis; Rupérez, Francisco J; Vázquez, Jesús; Barbas, Coral

    2016-06-01

    A single in-vial dual extraction (IVDE) procedure for the subsequent analysis of lipids and proteins in the high-density lipoprotein (HDL) and low-density lipoprotein (LDL) fractions derived from the same biological sample is presented. On the basis of methyl-tert-butyl ether (MTBE) extraction, IVDE leads to the formation of three phases: a protein pellet at the bottom, an aqueous phase with polar compounds, and an ether phase with lipophilic compounds. After sample extraction, performed within a high-performance liquid chromatography vial insert, the ether phase was directly injected for lipid fingerprinting, while the protein pellet, after evaporation of the remaining sample, was used for proteomics analysis. Human HDL and LDL isolates were used to test the suitability of the IVDE methodology for lipid and protein analysis from a single sample in terms of data quality and matching composition to that of HDL and LDL. Subsequently, HDL and LDL fractions isolated from ApoE-KO and wild-type mice were used to validate the capacity of IVDE for revealing changes in lipid and protein abundance. Results indicate that IVDE can be successfully used for the subsequent analysis of lipids and proteins with the advantages of time saving, simplicity, and reduced sample amount. PMID:27117984

  6. Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS

    Science.gov (United States)

    Previous analysis clustered 1,238 individuals from the general population Genetics of Lipid Lowering Drugs Network (GOLDN) study by the size of their fasting very low-density, low-density and high-density lipoproteins (VLDL, LDL, HDL) using latent class analysis. From two of the eight identified gro...

  7. Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice.

    Science.gov (United States)

    Kareinen, Ilona; Cedó, Lídia; Silvennoinen, Reija; Laurila, Pirkka-Pekka; Jauhiainen, Matti; Julve, Josep; Blanco-Vaca, Francisco; Escola-Gil, Joan Carles; Kovanen, Petri T; Lee-Rueckert, Miriam

    2015-02-01

    Reverse cholesterol transport (RCT) pathway from macrophage foam cells initiates when HDL particles cross the endothelium, enter the interstitial fluid, and induce cholesterol efflux from these cells. We injected [(3)H]cholesterol-loaded J774 macrophages into the dorsal skin of mice and measured the transfer of macrophage-derived [(3)H]cholesterol to feces [macrophage-RCT (m-RCT)]. Injection of histamine to the macrophage injection site increased locally vascular permeability, enhanced influx of intravenously administered HDL, and stimulated m-RCT from the histamine-treated site. The stimulatory effect of histamine on m-RCT was abolished by prior administration of histamine H1 receptor (H1R) antagonist pyrilamine, indicating that the histamine effect was H1R-dependent. Subcutaneous administration of two other vasoactive mediators, serotonin or bradykinin, and activation of skin mast cells to secrete histamine and other vasoactive compounds also stimulated m-RCT. None of the studied vasoactive mediators affected serum HDL levels or the cholesterol-releasing ability of J774 macrophages in culture, indicating that acceleration of m-RCT was solely due to increased availability of cholesterol acceptors in skin. We conclude that disruption of the endothelial barrier by vasoactive compounds enhances the passage of HDL into interstitial fluid and increases the rate of RCT from peripheral macrophage foam cells, which reveals a novel tissue cholesterol-regulating function of these compounds. PMID:25473102

  8. Cholesterol/HDL-c ratio lowering effect of green tea in rats exposed to depot medroxiprogesterone acetate

    Directory of Open Access Journals (Sweden)

    Elly Susilawati

    2015-09-01

    Conclusion: Green tea extract inhibits the increase in LDL-c and cholesterol/HDL-c ratio induced by DMPA. This may provide a natural therapeutic alternative for normalizing the lipid profile found in subjects exposed to DMPA. [J Exp Integr Med 2015; 5(3.000: 165-167

  9. Análisis de los efectos de un programa nutricional y de ejercicio físico sobre el perfil lipídico en personas con sobrepeso y obesidad

    OpenAIRE

    Romero Moraleda, Blanca

    2014-01-01

    Introducción. Las enfermedades cardiovasculares (ECV) son la principal causa de muerte en nuestro país. Entre los factores independientes más importantes para el desarrollo de ECV se encuentran en primer lugar las alteraciones del perfil lipídico como el aumento del colesterol total (TC), las lipoproteínas de baja densidad (LDL) y los triglicéridos (TG) y/o la disminución de las lipoproteínas de alta densidad (HDL). Entre las diferentes formas de abordar el problema para prevenir y tratar est...

  10. TransAlta Corporation 1996 annual report : new directions, new opportunities

    International Nuclear Information System (INIS)

    TransAlta Corp. is an energy management company that operates through two subsidiaries: (1) TransAlta Utilities Corp. which owns and operates electricity generation, transmission and distribution assets in Alberta, and (2) TransAlta Energy Corp. which is in the business of electric and thermal energy supply, gas and electricity distribution, energy services and energy marketing in regions of Canada, New Zealand, Australia, Argentina and the United States. This report presents a summary of operations, and provides consolidated financial statements and common share information for 1996. During the year the corporation advanced three significant initiatives (1) operational effectiveness, as shown by impressive productivity increases, and major investments in three independent power projects, (2) improved strategic direction through a review of plans and options, resulting in a clearer, more focused vision of the future, and (3) realignment of the organizational structure by centralizing marketing and sales functions, and establishing a corporate business development group. Details of operational and financial results were provided for both subsidiaries, i. e. TransAlta Utilities and TransAlta Energy. Sales of electric energy for TransAlta Utilities amounted to 27.8 billion kWh; 4.6 billion kWh for TransAlta Energy. Return on equity was 11.4 per cent, down from 11.8 per cent in 1995. Net earnings per common share were $1.14 per share (including one-time items), the same as in 1995. tabs., figs

  11. Comparação das frações HDL e LDL colesterol como fatores de risco para a aterosclerose carotídea Comparative study of HDL and LDL cholesterol as risk factors for carotid atherosclerosis

    Directory of Open Access Journals (Sweden)

    Rubens José Gagliardi

    1995-12-01

    Full Text Available Estudo prospectivo com o objetivo de verificar qual das frações do colesterol sanguíneo, HDL ou LDL, é mais significativa para o desenvolvimento da aterosclerose das artérias carótidas (AC. Constou de 125 indivíduos de ambos os sexos, com idade entre 45 a 75 anos, incluídos aleatoriamente. Em todos foi procedida a dosagem sanguínea do colesterol total e das frações HDL e LDL e estudo ultrassonográfico (através de ultrassonografia modo B das AC. Os resultados mostraram que a presença de placa de ateroma, com ou sem estenose nas AC, é inversamente proporcional aos níveis de HDL. Estes achados foram estatisticamente significantes (x2=6,57 e x2=9,24, respectivamente para placa sem estenose e com estenose; x2 crítico = 5,99 para α=5% . Foi também constatada associação entre a presença de placa aterosclerótica na AC e níveis sangüíneos elevados de LDL: quanto maiores os níveis de LDL, maior a proporção de indivíduos com placas, porém este achado não foi estatisticamente significante (x2=0,97, x2 crítico 5,99 para α =5%. Não foi encontrada nesta casuística relação entre níveis elevados de LDL e presença de estenose nas AC. Estes resultados, ainda que iniciais, sugerem que níveis baixos de HDL são mais aterogênicos para as AC comparativamente a níveis elevados de LDL.In order to find out whether there exists a relationship between HDL and LDL serum levels and atherosclerotic plaques in the carotid artery (CA, a prospective study was carried out involving 125 patients. They were aleatorily included, of both sexes and age between 45-75 years old. HDL and LDL serum levels were measured as well CA ultrasonographic mode B investigated. It was verified that the number of patients having atherosclerotic plaques in CA was inversely proportional to the HDL levels. We came up with the same ratio when the HDL levels were compared to the number of patients having CA stenosis. These results were statistically signifcant (x

  12. CHANGES OF HDL-C AND LDL-C OF DIABETIC RATS AND REGULATORY EFFECTS OF SERICIN%糖尿病大鼠HDL-C和LDL-C的变化及丝胶的调节作用

    Institute of Scientific and Technical Information of China (English)

    杨振军; 张艳; 侯丽娜; 刘东慧; 陈志宏

    2013-01-01

    目的:探讨丝胶对2型糖尿病大鼠低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)的调节作用。方法:48只雄性SD大鼠随机分为正常对照组、糖尿病模型组、丝胶治疗组和阳性对照组,每组12只大鼠。25mg/kg链脲佐菌素腹腔注射3d(1次/d)建立2型糖尿病大鼠模型;模型成功建立后,糖尿病模型组大鼠不再做任何处理,丝胶治疗组大鼠给予丝胶(2.4g/kg/d)灌胃35d,阳性对照组大鼠给予二甲双胍(55.3mg/kg/d)灌胃35d。分别检测各组大鼠的血糖以及血清HLD-C和LDL-C的水平。结果:与正常对照组大鼠比较,模型组大鼠的血糖、LDL-C明显升高,HDL-C明显降低(P<0.01,P<0.05);与模型组大鼠比较,丝胶治疗组、阳性对照组大鼠的血糖、LDL-C明显降低,HDL-C明显升高(P<0.01)。结论:丝胶可通过提高HDL-C水平、降低LDL-C水平改善糖尿病时血脂代谢紊乱。%Objective:To investigate the regulatory effects of sericin on low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) of type 2 diabetic rats.Methods:48 male SD rats were randomly divided into normal control group, diabetes model group, sericin treatment group and positive control group (n=12). Streptozotocin (25mg/kg) was injected into the peritoneal cavity for 3 days (one time a day) to establish type 2 diabetes rats model. Then the rats in model group received no more treatments;the rats in sericin treatment group were lavaged sericin (2.4g/kg/d) for 35-day;the rats in positive control group were lavaged metformin (55.3mg/kg/d) for 35-day. The blood glucose, HDL-C and LDL-C of rats in each group were respectively detected.Results:Compared with rats in normal control group, the blood glucose and LDL-C of rats in model group increased obviously, while HDL-C decreased obviously (P<0.01,P<0.05). Compared

  13. Impact of Nursery Seeding Density, Nitrogen, and Seedling Age on Yield and Yield Attributes of Fine Rice Impacto de la Densidad de Siembra en Vivero, Nitrógeno, y Edad de Plántula sobre Rendimiento y Atributos de Rendimiento de Arroz Fino

    Directory of Open Access Journals (Sweden)

    Naeem Sarwar

    2011-09-01

    diferentes densidades de siembra (alta y baja y condiciones de N (con y sin en el cultivo del arroz temporadas 2008 y 2009. Independiente de la densidad de siembra y la aplicación de fertilizantes, plántulas de vivero de 10-d presentaron mayores rendimientos y componentes de rendimiento (tallos productivos, altura de planta, peso de 1000 granos, y rendimiento de paja, mientras que en etapas posteriores se observó una interacción significativa con el manejo de vivero. El trasplante de plántulas fértiles de 20 d cultivadas con baja densidad de siembra en la cama del vivero, se tradujo en un mayor número de macollos productivos m-2 (233,3; 227,3, producción de paja (11,1; 10,7 t ha-1, y rendimiento final (3,6; 3,4 t ha-1, en los años 2008 y 2009 respectivamente. Los atributos de rendimiento y el rendimiento se redujeron significativamente después del trasplante plántulas mayores cultivadas con alta densidad de siembra y sin fertilizante en vivero. Producción de macollos (165,7; 133, rendimiento de paja (8,7; 8,1 t ha-1 y rendimiento de arroz (2,0; 1,8 t ha-1 mínimos se registraron con trasplante de plántulas mayores de 40 d cultivadas con alta de densidad de siembra y sin aplicación de N. Estos hallazgos sustentan el uso de plántulas jóvenes en un sistema de intensificación de arroz e ilustran que con una pequeña inversión adicional en el cultivo de plántulas sanas y vigorosas en la cama de semillas del vivero, los agricultores pueden aumentar los rendimientos.

  14. Basic density and pulp yield relationship with some chemical parameters in eucalyptus trees Densidade e rendimento em polpa celulósica e sua relação com alguns parâmetros químicos no eucalipto

    Directory of Open Access Journals (Sweden)

    Ana Maria Loureiro da Seca

    2006-12-01

    /guaiacilo (S/G e seringaldeído/vanilina (S/V. As amostras dos quartis de alta densidade e as de baixo rendimento foram semelhantes, ambas com baixos valores de S/V (3,99-4,09 e S/G (3,88-4,12 e os mais elevados teores de fenóis totais (13,3-14,3 g de ácido gálico por quilograma. As madeiras do quarto quartil de rendimento são estatisticamente distintas das outras, com as maiores razões S/G (5,15 e S/V (4,98 e os menores teores de fenóis totais (8,7 g de ácido gálico por quilograma. Os parâmetros grupos metoxílicos e açúcares totais são os mais adequados para a diferenciação das amostras provenientes do primeiro quartil de densidade.

  15. Sistema de monitorización continua de descargas parciales para trasformadores de alta potencia

    OpenAIRE

    Lastra Rodríguez, Daniel

    2012-01-01

    La monitorización de transformadores de alta potencia se presenta como una tarea crucial dentro del mantenimiento de las subestaciones eléctricas. Además de pérdidas de suministro, los fallos en los transformadores de alta potencia llevan asociados una serie de costes que en ocasiones pueden llegar a dispararse. Mientras se encuentra en servicio, un transformador de alta potencia proporciona gran variedad de información entre la que podemos destacar la facilitada por las descargas parciales p...

  16. Hemorragia digestiva alta em idosos e não idosos

    OpenAIRE

    Pereira, Tiago José Felizardo

    2012-01-01

    A Hemorragia Digestiva Alta tem vindo apresentar um crescimento significativo em idosos, contribuindo com 35 a 45% dos casos de Hemorragia Digestiva Alta. Foi realizado um estudo descritivo, observacional e transversal, com o objetivo de identificar quais as características epidemiológicas das Hemorragias Digestivas Altas em idosos e não idosos admitidos na Unidade de Endoscopia Digestiva do Centro Hospitalar Cova da Beira, na Região da Cova da Beira – Portugal, no período de 1...

  17. Estudio de capas delgadas de dieléctricos de alta permitividad depositadas por ALD

    OpenAIRE

    Fuentes Díaz, Lissa María

    2014-01-01

    El impulso acelerado de la industria microelectrónica ha conducido al empleo de dieléctricos de alta permitividad (K) como una alternativa para continuar el escalado. Tanto en aplicaciones espaciales, médicas, como de física de alta energía los transistores son sometidos a ambientes de fuertes irradiaciones provocando una degradación progresiva de los dispositivos. La respuesta de la fiabilidad de los dieléctricos de alta K frente la irradiación determinará su viabilidad e inco...

  18. Altas Capacidades en Educación Infantil en Guipúzcoa

    OpenAIRE

    Omaetxebarria-Aldarono, Ainara

    2013-01-01

    El trabajo fin de grado que se presenta a continuación aporta información acerca de las altas capacidades en Educación Infantil y su relación con las inteligencias múltiples. Se propone una perspectiva de la realidad actual del tema en el contexto de la provincia de Guipúzcoa. Las altas capacidades se proponen aludiendo a varios aspectos, entre ellos, se define el término, se aportan características de los alumnos con altas capacidades, se señalan alternativas de intervención en las aulas y s...

  19. Altas capacidades intelectuales. Diagnóstico y seguimiento de una NEE.

    OpenAIRE

    Pérez-i-Martra, Pep

    2013-01-01

    Según la OMS, el 2,3% de la población mundial tiene altas capacidades intelectuales, es decir, en la vida académica de un profesor, éste tendría que descubrir una media de 40 alumnos con capacidades superiores a la media. Saber en qué consisten las altas capacidades y hacer un pre diagnóstico de las mismas será, en muchas ocasiones, trabajo del profesor de secundaria. Pero, ¿tiene éste conocimientos para percatarse de la presencia en clase de un alumno con altas capacidades? ¿Y una vez estudi...

  20. El alumnado con altas capacidades intelectuales: programas de intervención.

    OpenAIRE

    González Arranz, Raquel

    2015-01-01

    El presente Trabajo de Fin de Grado se centra en alumnos considerados de Educación Especial, concretamente en aquellos que poseen Altas Capacidades Intelectuales y las posibilidades de respuesta educativa que se les puede ofrecer dentro del modelo de aula ordinaria. En la primera parte, se afronta el estudio de alumnos con altas capacidades intelectuales en educación primaria. Los temas que se tratan son: conceptualización y definiciones, fundamentación teórica de alumnos con altas capaci...

  1. Espondiloartritis y su relación con las fracturas vertebrales y la densidad mineral ósea

    OpenAIRE

    Sánchez González, María Dolores

    2016-01-01

    [ES] En el presente trabajo se estudia la espondilitis anquilosante (EA), enfermedad inflamatoria crónica más común en varones, y la relación de la misma con las fracturas vertebrales y la densidad mineral ósea, debido a que en los varonos como resultado de una respuesta inmune, se produce una inflamación en las articulaciones sacroiliacas, vertebrales y otras adyacentes. Es frecuente que los pacientes también tengan inflamación en las entesis (inserción del tendón o del ligamento en el hues...

  2. Biomasa y densidad de dos especies de pastos marinos en el sur de Quintana Roo, México

    OpenAIRE

    Martha Angélica Gutiérrez-Aguirre; María Gabriela de la Fuente-Betancourt; Adrián Cervantes-Martínez

    2000-01-01

    La biomasa y productividad de una comunidad de pastos marinos es útil para determinar el estado ecológico de la costa. Se comparó la biomasa foliar y la densidad de vainas en praderas de Thalassia testudinum Banks & Sol. ex K. D. Koenig, en dos ambientes de la costa del Caribe mexicano (N= 6 cuadrantes/sitio) en Noviembre de 1998. Los valores de vainas y biomasa foliar fueron más bajos en la pradera asociada al manglar, que en la pradera establecida en una laguna arrecifal. Esto probablemente...

  3. Densidad ósea y frecuencias de restos humanos en Tierra del Fuego. Análisis exploratorio

    OpenAIRE

    Suby, Jorge A.; Guichón, Ricardo Aníbal

    2003-01-01

    La disponibilidad del registro biológico humano para su estudio esta condicionada por procesos paleoecológicos y tafonómicos. Cuales probablemente van a ser los especimenes mejor y peor representados constituye un dato importante al momento de decidir que preguntar. En relación con esta problemática nos interesa explorar la relación entre la densidad mineral ósea y las frecuencias relativas con que se presenta el registro biológico humano en varias colecciones del norte de Tierra del Fuego. L...

  4. Densidad del Mono aullador Alouatta seniculus (Linnaeus, 1766) Mammalia: primates en el arroyo coloso, Departamento de Sucre, Colombia

    OpenAIRE

    Fajardo Patiño Alirio; De la Ossa Velasquez Jaime L.

    1996-01-01

    Nueve manadas de Alouatta seniculus, fueron estudiadas a lo largo de tres meses y medio, entre Mayo y Agosto de 1983. Se tomaron en cuenta aspectos relativos al estado y densidad poblacional en el Arroyo Colosó, Departamento de Sucre. Se establece una relación de los datos obtenidos y procesados en este trabajo con los suministrados por otros autores en estudios similares con la misma especie y en diferentes lugares.Nine troops of Alouatta seniculus, were studied for a period of three and hal...

  5. Densidad y biomasa de Pterois volitans/miles (Teleostei: Scorpaenidae) en arrecifes del litoral oeste de La Habana, Cuba

    OpenAIRE

    García-Rodríguez, Alain; Chevalier Monteagudo, Pedro P.; Cabrera Sansón, Erlán; Caballero Aragón, Hansel; Luis Hernández López, Jorge

    2015-01-01

    El pez león (Pterois volitans/miles) es la primera especie (s) de pez arrecifal del Indo- Pacífico que invade el Atl{ntico Occidental, constituyendo una de las invasiones de peces marinos m{s r{pida de la historia. El objetivo fue determinar la densidad y biomasa de las poblaciones del pez león y sus posibles variaciones temporales y espaciales en arrecifes del oeste de La Habana, Cuba. Los muestreos fueron realizados mediante censos visuales con buceo autónomo en los períodos ...

  6. Densidade de semeadura de duas espécies de ervilhaca sobre caracteres agronômicos e composição bromatológica

    Directory of Open Access Journals (Sweden)

    Sidney Ortiz

    2015-02-01

    Full Text Available O estande de plantas é um dos principais componentes do rendimento que altera a produtividade das culturas, maximizando o ambiente produtivo para a cultura. Nesse sentido, objetivou-se com este trabalho avaliar a produção de forragem e a composição química de duas espécies de ervilhaca em diferentes densidades de semeadura. O experimento foi conduzido no ano de 2011, em área experimental do Departamento de Fitotecnia da Universidade Federal de Santa Maria, Rio Grande do Sul. Os tratamentos constaram de duas espécies de ervilhaca (ervilhaca peluda e ervilhaca comum em quatro densidades de semeadura (50, 100, 150 e 200 sementes m-2. O delineamento experimental utilizado foi o de blocos ao caso, disposto em fatorial (2x4, em quatro repetições. Os valores de FDA aumentaram conforme o aumento da densidade de semeadura, o que não ocorreu para as demais características bromatológicas avaliadas. A densidade ótima de semeadura deve ser ajustada conforme a espécie e o corte, variando de 66 a 200 sementes viáveis por metro quadrado. A produção de massa seca total é maximizada quando a densidade de semeadura for de 136 sementes viáveis m-2

  7. Monitorización del estrés hídrico en un olivar en seto de alta densidad con sondas de presión de turgencia en hojas

    OpenAIRE

    Rodríguez Domínguez, Celia M.

    2011-01-01

    70 páginas.-- 15 figuras.-- 1 tabla.-- 71 referencias.-- Curso 2010-2011. Trabajo de iniciación a la investigación. Memoria para optar al Diploma de Estudios Avanzados por la Universidad de Sevilla. Línea de investigación "Efecto medioambiental de los fertilizantes y el riego en la agricultura"

  8. Dosimetry characterization and clinical application of Exa skin: Bolus of high of high density for use with photons; Caracterizacion dosimetrica y aplicacion clinica de Exaskin: bolus de alta densidad para uso con fotones

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz Seidel, M.; Velazquez Miranda, S.

    2013-07-01

    Bolus of high density eXaSkin of density 1.6 g/cm{sub 3} is calculated correctly in the planning systems, is easy to use and generates optimum coupling with the radiation area, at the same time which is easily reproducible in their placement, avoiding the use of electron beams. On the other hand its behavior varies very slightly with the presence of air gaps. (Author)

  9. Características de compósitos laminados manufaturados com polietileno de alta densidade (PEAD e diferentes proporções de casca de arroz e partículas de madeira

    Directory of Open Access Journals (Sweden)

    Dalva Teresinha Pauleski

    2007-01-01

    Full Text Available The objective of this work was to analyse the feasibility of the utilization of rice husks and wood particles in the manufacture of wood plastic composites, in a way similar to particleboard fabrication. The composites were made with rice husks and Eucalyptus grandis wood particles, pure or mixed, in proportions of 0, 25, 50, 75 and 100% of ovendry weight. High density polyethylene (HDPE was used as matrix in the manufacture in three proportions: 60, 75, and 90%. Bending properties, internal bond, water absorption and thickness swelling after 24 hours of water soaking and after 15 soaking cycles were evaluated. The values of bending properties were influenced by the density of the composite. In the case of internal bond, the values were within the limits established by commercial particleboard standards, being the HDPE proportion the parameter of higher correlation with this property. Rice husk caused lower thickness swelling and, independently of the type of raw material utilised, the values decreased with the increase of HDPE. Combinations with larger percentages of HDPE presented minimal values or, in some cases, null of water absorption. For the water absorption and thickness swelling after 15 cycles the behavior was similar to that of the 24 hour period. Results allowed concluding that the composites made with HDPE, rice husks and wood particles pure or mixed present good quality, evidencing the adequacy of these raw material and process in manufacturing this type of panel.

  10. Preparation and characterization of high density polyethylene and residual fibre of Attalea funifera Mart (piacava) composites; Preparacao e caracterizacao de compositos de polietileno de alta densidade com residuos de fibras de piacava da especie Attalea funifera Mart

    Energy Technology Data Exchange (ETDEWEB)

    Agrela, Sara P.; Guimaraes, Danilo H.; Jose, Nadia M., E-mail: saraagrela@hotmail.co [Universidade Federal da Bahia (GECIM/IQ/UFBA), Salvador, BA (Brazil). Inst. de Quimica. Grupo de Energia e Ciencias dos Materiais; Carvalho, Gleidson G.P. [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil). Escola de Medicina Veterinaria. Dept. de Producao Animal; Carvalho, Ricardo F. [Universidade Federal da Bahia (EP/UFBA), Salvador, BA (Brazil). Escola Politecnica. Curso de Mestrado em Engenharia Ambiental Urbana

    2009-07-01

    The use of natural fiber reinforcement thermoplastic polymer is continuously increasing. This fact is manly due to its advantages as low cost, availability, recyclability, low energy demand and then environmental appeal if compared to synthetics fibers. The composites were prepared in different fiber volume ratios (5%, 10% and 20%) mixed with high density polyethylene (HDPE) and heated at 190 deg C. Thermogravimetric analysis and differential scanning calorimetry were used to investigate thermal stability. The composites structure was characterized by Fourier Transform Infrared spectroscopy, X-ray diffractometry. Fiber and residue of piassava (Attalea funifera Mart) chemical composition were determined by Van Soest Method. The results indicate that thermo stability of the composites of HDPE prepared with fiber volume ratios up to 20% is only slightly lowered. (author)

  11. Higher glandular trichome density in tomato leaflets and repellence to spider mites Alta densidade de tricomas glandulares em tomateiro e aumento da repelência a ácaros rajados

    OpenAIRE

    Wilson Roberto Maluf; Irene Fumi Inoue; Raphael de Paula Duarte Ferreira; Luiz Antonio Augusto Gomes; Evaristo Mauro Castro; Maria das Graças Cardoso

    2007-01-01

    The objective of this work was to evaluate the feasibility of selection for higher glandular trichome densities, as an indirect criterion of selection for increasing repellence to spider mites Tetranychus urticae, in tomato populations derived from an interspecific cross between Lycopersicon esculentum x L. hirsutum var. glabratum PI 134417. Trichome densities were evaluated in 19 genotypes, including 12 from advanced backcross populations, derived from the original cross L. esculentum x L. h...

  12. Transporte de juvenis de curimbatá Prochilodus lineatus em diferentes densidades - doi: 10.4025/actascianimsci.v32i2.8415 Transportation of curimbata Prochilodus lineatus juveniles in different densities - doi: 10.4025/actascianimsci.v32i2.8415

    Directory of Open Access Journals (Sweden)

    João Batista Kochenborger Fernandes

    2010-07-01

    Full Text Available Neste estudo foi avaliado o efeito do transporte de curimbatá Prochilodus lineatus, em três densidades (100, 150 e 250 g L-1, sobre a sobrevivência e variáveis metabólicas, iônicas e hematológicas (série vermelha. Juvenis de curimbatá foram transportados em sacos plásticos durante 6h e amostrados antes da embalagem, imediatamente após a chegada, 24 e 96h após o transporte. Os peixes transportados na densidade mais alta apresentaram maior mortalidade durante o período de recuperação. As variáveis físico-químicas da água: condutividade e amônia total apresentaram maiores valores quanto maior a densidade (p -1 induziu maior mortalidade e os piores valores nas variáveis avaliadas. O período de 96h de recuperação após evento estressante foi suficiente para o retorno aos valores basais das variáveis hematológicas, mas não foi suficiente para as metabólicas e iônicas. aThis study evaluated the effects of curimbata Prochilodus lineatus transportation in three densities (100, 150 and 250 g L-1 on survival, metabolic, ionic and hematological (red series variables. Curimbata juveniles were transported in plastic bag during six hours, and sampled before packing, immediately after the arrival, 24 and 96 hours after transportation. During recovery, higher mortality was seen in fish transported in the highest density. Water variables, such as conductivity and total ammonia, presented increased values as density increased (p -1 density induced the highest mortality rate and the worst variables values measured. 96 hours of recovery after the stressing event was enough to return to initial values for hematological variables, but was not sufficient to return to initial values for metabolic and ionic variables.

  13. Neuromielitis óptica con alta expresión de acuaporina-4 y anticuerpos anti-acuaporina-4 positivos en suero

    Directory of Open Access Journals (Sweden)

    Alejandra Báez

    2012-04-01

    Full Text Available La presencia de anticuerpos IgG en suero, con blanco en los canales de acuaporina-4, es específica de la neuromielitis óptica (NMO. El 60% de los pacientes con NMO presentan lesiones cerebrales en la resonancia magnética (RM; en un 8% (mayoría niños estas lesiones se consideraron "atípicas". Presentamos dos pacientes con NMO y lesiones en el SNC de alta expresión de acuaporina-4. Caso 1: varón de 50 años, que comenzó con pérdida de visión en ojo derecho (OD. Recibió tratamiento empírico con metilprednisolona 1 g/d x 3 días. Al mes presentó dolor generalizado y hemiparesia derecha; nuevamente recibió metilprednisolona 1 g/d x 5 días e IgG IV 400 mg/kg/d × 5 días. Recuperó la deambulación persistiendo el dolor y fenómenos paroxísticos en los 4 miembros. Potenciales evocados visuales: P100, ojo izquierdo (OI 123 mseg. OD sin respuesta. La RM de cerebro (FLAIR mostró hiperintensidad en nervio óptico derecho, hipotálamo y comisura blanca anterior. RM cervical: lesión medular extensa (5 cuerpos vertebrales. Caso 2: mujer de 53 años, con disminución de la agudeza visual en ambos ojos y parestesias en miembros inferiores que remitieron espontáneamente. Evolucionó al mes con cuadriparesia e incontinencia esfinteriana. Recibió metilprednisolona 1 g/d x 5 días, sin mejoría. Potenciales evocados visuales: P100 OI 124 mseg. OD 128 mseg. RM cerebro: (FLAIR hiperintensidad hipotalámica y periacueductal. RM cervical: lesión medular extensa (7 cuerpos vertebrales. Anticuerpos anti-acuaporina-4 positivos en ambos pacientes (inmunofluorescencia indirecta. Las lesiones consideradas "atípicas", como aquí, en sitios con alta densidad de proteínas canales de agua AQP4 deberán considerarse para el diagnóstico diferencial.

  14. Caracterización morfométrica de la cuenca alta del arroyo Las Lajas, Córdoba: Un análisis estadístico

    Directory of Open Access Journals (Sweden)

    N. Doffo

    2005-03-01

    Full Text Available En base a un análisis estadístico de los principales parámetros morfomé tricos, se hace una caracterización hidrológica de la cuenca alta del arroyo Las Lajas. En particular se discute la influencia de la estructura y litología sobre el diseño de la red de drenaje. La cuenca alta del arroyo Las Lajas drena una superficie aproximada de 41 km² y se desarrolla sobre un basamento plutónico-metamórfico del Precámbrico-Paleozoico superior. El relieve está conformado por serranías bajas, valles de fondo plano, con relleno aluvial y coluvial. La precipitación media anual es de 860 mm. La forma de la cuenca está parcialmente controlada por la Falla Las Lajas. Los parámetros morfométricos utilizados son: densidad de drenaje, frecuencia de cursos de primer orden, rugosidad de la cuenca, relación de bifurcación, relación de longitudes y relación de elongación. Estos se aplicaron a subcuencas de tercer orden, agrupadas en un sector oriental y otro occidental, delimitados por la Falla Las Lajas. De cada parámetro medido se obtuvieron estadísticos de posición y de dispersión y se realizaron, previa prueba de normalidad y de correlación, tests estadísticos, análisis de agrupamiento y factorial. El resultado no demuestra que exista un control litológico sobre el diseño de la red de drenaje. Un análisis de agrupamiento sobre las subcuencas indica una división en dos conjuntos que no muestran una relación obvia con la estructura ni la litología del sustrato.

  15. Efeitos da atividade física na densidade mineral óssea e na remodelação do tecido ósseo Efectos de la actividad física en la densidad mineral ósea y en la remodelacion del tejido óseo Effects of the physical activity on the bone mineral density and bone remodelation

    Directory of Open Access Journals (Sweden)

    Eduardo Lusa Cadore

    2005-12-01

    Full Text Available Este artigo revisa os efeitos de diferentes modalidades esportivas e do treinamento de força na remodelação óssea e discutir as possíveis relações da densidade mineral óssea (DMO com a força muscular e a composição corporal. Numerosos estudos indicam que a atividade física de alto impacto, ou que exija alta produção de força, pode ter um efeito benéfico na DMO, devido à deformação desse tecido, ocorrida durante a atividade. Alguns autores têm avaliado os efeitos do treinamento físico em alguns marcadores bioquímicos da remodelação óssea, já que a variação das concentrações desses marcadores pode indicar um estado de formação ou reabsorção óssea. Entretanto, a inconsistência dos resultados encontrados sugere que a análise dos efeitos da atividade física na remodelação óssea, através desses marcadores, deve ser mais investigada. Existem muitas discrepâncias a respeito da relação entre a DMO com a força muscular e a composição corporal, principalmente na determinação de qual desses fatores está mais associado com a DMO. A determinação de qual o tipo de atividade física seja ideal para aumentar o pico de massa óssea na adolescência, ou mesmo mantê-la após a idade adulta, é muito importante para a prevenção e o possível tratamento da osteoporose.Este artículo busca revisar los efectos de modalidades deportivas diferentes y del entrenamiento de fuerza en la remodelación del hueso y discutir las posibles relaciones entre la densidad mineral del hueso (DMO con la fuerza muscular y la composición corporal. Los numerosos estudios indican que la actividad física de alto impacto o que exige producción alta de fuerza, pueden tener un efecto beneficioso en la DMO, debido a la deformación que ese tejido, pasa durante la actividad física. Algunos autores han estado evaluando los efectos de la educación física en algunos marcadores bioquímicos de la remodelación del hueso, desde la variaci

  16. Audiitor kaebas Alta Capitali arve pärast Läti kohtusse / Henrik Ilves

    Index Scriptorium Estoniae

    Ilves, Henrik

    2008-01-01

    Eesti Päevalehe andmetel kaebas rahvusvaheline audiitorfirma Ernst & Young Lätis kohtusse investeerimisfirma Alta Capital, kuna firma ei ole maksnud esitatud arvet. Nõude suuruseks on 4,69 miljonit krooni

  17. Il programma italiano di ricerche nella alta atmosfera

    Directory of Open Access Journals (Sweden)

    l. BROGLIO

    1962-06-01

    Full Text Available La Commissione per le Ricerche Spaziali, nominata dal ConsiglioNazionale delle Ricerche diciotto mesi fa, ha intrapreso un programmadi studio dell'alta atmosfera a mezzo di razzi sonda. Questa ricerca,che nella attuale prima fase di lavoro e sviluppo deve essere consideratauna delle attività basilari della Commissione, aveva ed ha un duplicescopo: uno scopo diretto, immediato, che consiste nell'acquisizione didati scientifici, in maggior copia possibile, tali da ampliare ed approfondirele attuali conoscenze sulla struttura e sulla dinamica della altaatmosfera.Il secondo scopo è, se così si può dire, proiettato nel futuro. L'organizzazionepredisposta, sia in uomini che in attrezzature ed installazioni,per questa ricerca può considerarsi infatti come il nocciolo di unapiù ampia organizzazione che potrà operare negli anni successivi permaggiori e più impegnativi compiti.I fondi necessari per lo sviluppo del programma di ricerche nell'altaatmosfera sono stati forniti alla Commissione delle Ricerche Spazialiin base ad un accordo fra il C.N.R. e il Comitato Razzi e Missili delMinistero della Difesa, secondo il quale i due Enti si impegnavano acontribuire alle spese necessarie su base paritetica.II C.N.R. stipulò anche un accordo di natura scientifica con l'Entespaziale statunitense N.A.S.A., sia per ottenere dalla Commissione delleRicerche Spaziali un appoggio tecnico, sia per altre finalità di cui siparlerà più diffusamente in seguito.

  18. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL))

    Czech Academy of Sciences Publication Activity Database

    Dobiášová, Milada; Frohlich, J.

    2001-01-01

    Roč. 34, č. 7 (2001), s. 583-588. ISSN 0009-9120. [Congress of the European Atherosclerosis Society /71./. Athens, 26.05.1999-29.05.1999] R&D Projects: GA ČR GV306/96/K220; GA MZd NE5465 Institutional research plan: CEZ:AV0Z5011922 Keywords : atherogenic index of plasma * HDL-cholesterol * triglycerides Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 1.516, year: 2001

  19. Demografia e densidade de perfilhos de capim-braquiária sob pastejo em lotação intermitente

    Directory of Open Access Journals (Sweden)

    Jorge Nunes Portela

    2011-03-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos de intensidades de pastejo e de frequências de desfolha na demografia e densidade de perfilhos de capim-braquiária (Urochloa decumbens syn. Brachiaria decumbens sob lotação intermitente. Foram avaliados duas intensidades de pastejo (5 e 10 cm de altura pós-pastejo e duas frequências de desfolha (período de descanso até que o dossel atingisse 95 e 100% de interceptação luminosa, IL, de agosto de 2007 a agosto de 2008. Utilizou-se o delineamento inteiramente casualizado, em arranjo fatorial com quatro repetições. Avaliaram-se as densidades populacionais e as taxas de aparecimento e sobrevivência de perfilhos basais (DPPb, TAPb e TSPb, respectivamente e aéreos+basais (DPPab, TAPab e TSPab. As maiores TAPb e TAPab, no outono, foram obtidas nos pastos desfolhados a 10 cm. Porém, no final da primavera e no verão, a intensidade de 5 cm resultou em maiores taxas, que promoveram maior DPPb. No verão, a TSPb foi maior para pastos manejados à intensidade de 10 cm. O manejo da pastagem que resulta em maiores DPPab, TAPab e TSPab, durante as épocas de rápido crescimento dos pastos, é o de 10 cm de intensidade de pastejo e 95% de IL de frequência de desfolha.

  20. Efecto de la densidad de siembra y la adición de ácido ascórbico en el cultivo de Osteoglossum bicirrhosum

    Directory of Open Access Journals (Sweden)

    Carolina Cuaical T.

    2013-11-01

    Full Text Available Objetivo. Evaluar el efecto de la densidad de siembra y la adición de ácido ascórbico en la alimentación de alevinos de O. bicirrhosum, cultivados en jaulas. Materiales y métodos. Se incluyeron 396 alevinos y se distribuyeron en nueve tratamientos, resultado de la combinación de los niveles del factor densidad de siembra: 1pez/5 L; 1pez/10 L y 1pez/15 L y los niveles de ácido ascórbico: 0; 500 y 1000 mg/kg. Los datos obtenidos se evaluaron mediante el análisis de varianza del diseño factorial 32. Resultados. La densidad de siembra presentó diferencias estadísticas significativas en el incremento de peso. Las variables incremento de longitud y tasa de crecimiento específico no presentaron diferencias estadísticas. En cuanto a la conversión alimenticia aparente, se demostraron diferencias significativas en los dos factores: La densidad de 1pez/10 L indicó la mejor conversión con un valor de 1.50, asimismo, la inclusión de 1000 mg de ácido ascórbico por Kg de alimento mostró los mejores promedios con 1.55. En la sobrevivencia se precisaron diferencias estadísticas entre los tratamientos de la densidad de 1pez/5 L, siendo mejores aquellos que incluyeron ácido ascórbico en la dieta. Conclusiones. La densidad de 1pez/10 L registró el mayor incremento de peso con 31.83 g en 87 días. La sobrevivencia general fue del 96%, lo que demuestra la eficiencia del sistema de cultivo utilizado, al tiempo que actúa de manera positiva en el desarrollo de esta especie.

  1. Static Calibration and Analysis of the Velodyne HDL-64E S2 for High Accuracy Mobile Scanning

    Directory of Open Access Journals (Sweden)

    Craig Glennie

    2010-06-01

    Full Text Available The static calibration and analysis of the Velodyne HDL-64E S2 scanning LiDAR system is presented and analyzed. The mathematical model for measurements for the HDL-64E S2 scanner is derived and discussed. A planar feature based least squares adjustment approach is presented and utilized in a minimally constrained network in order to derive an optimal solution for the laser’s internal calibration parameters. Finally, the results of the adjustment along with a detailed examination of the adjustment residuals are given. A three-fold improvement in the planar misclosure residual RMSE over the standard factory calibration model was achieved by the proposed calibration. Results also suggest that there may still be some unmodelled distortions in the range measurements from the scanner. However, despite this, the overall precision of the adjusted laser scanner data appears to make it a viable choice for high accuracy mobile scanning applications.

  2. HDL functionality in reverse cholesterol transport - Challenges in translating data emerging from mouse models to human disease.

    Science.gov (United States)

    Lee-Rueckert, Miriam; Escola-Gil, Joan Carles; Kovanen, Petri T

    2016-07-01

    Whereas LDL-derived cholesterol accumulates in atherosclerotic lesions, HDL particles are thought to facilitate removal of cholesterol from the lesions back to the liver thereby promoting its fecal excretion from the body. Because generation of cholesterol-loaded macrophages is inherent to atherogenesis, studies on the mechanisms stimulating the release of cholesterol from these cells and its ultimate excretion into feces are crucial to learn how to prevent lesion development or even induce lesion regression. Modulation of this key anti-atherogenic pathway, known as the macrophage-specific reverse cholesterol transport, has been extensively studied in several mouse models with the ultimate aim of applying the emerging knowledge to humans. The present review provides a detailed comparison and critical analysis of the various steps of reverse cholesterol transport in mouse and man. We attempt to translate this in vivo complex scenario into practical concepts, which could serve as valuable tools when developing novel HDL-targeted therapies. PMID:26968096

  3. Transmissividade a radiação solar do polietileno de baixa densidade utilizado em estufas Solar radiation transmissivity through low density polyethylene used in greenhouses

    OpenAIRE

    Galileo Adeli Buriol; Nereu Augusto Streck; Cláudia Petry; Flavio Miguel Schneider

    1995-01-01

    Determinou-se a transmissividade à radiação solar do polietileno de baixa densidade utilizado em estufas. O experimento foi conduzido em uma estufa tipo Capela com dimensões de 10m x 25m, coberta com polietileno transparente de baixa densidade, com espessura de 100µm e aditivado com anti-UV, instalada no Departamento de Fitotecnia da Universidade Federal de Santa Maria, RS - Brasil. A radiação solar global diária incidente no interior e exterior da estufa foi medida no período de julho de 199...

  4. Produção do milho híbrido 30F35HR cultivado na savana de Roraima em diferentes densidades de plantio.

    OpenAIRE

    Valle, Ítalo César Aguiar; Alves, José Maria Arcanjo; Silva, Luana dos Santos; Uchôa, Sandra Cátia Pereira; Albuquerque, José de Anchieta Alves de; Silva, Deyse Cristina Oliveira da

    2013-01-01

    A densidade de plantas pode maximizar o potencial produtivo de variedades de milho melhoradas, uma vez que, em geral, estas apresentam porte mais baixo e arquitetura foliar mais ereta. Objetivou-se com esse trabalho avaliar o efeito de três densidades de plantios nos componentes de produção do milho transgênico híbrido Pioneer 30F35HR cultivado na savana de Roraima. O experimento foi conduzido na área experimental do Centro de Ciências Agrárias da Universidade Federal de Roraima, no Campus do...

  5. Densidades de plantio e doses de biofertilizante na produção de capim-limão Density and biofertilizer levels for lemon grass production

    OpenAIRE

    Blank, Arie F.; Maria de Fátima Arrigoni-Blank; Verônica F Amancio; Marcelo da C Mendonça; Luiz G M de Santana Filho

    2007-01-01

    O objetivo do trabalho foi avaliar o efeito de densidades de plantio e doses de biofertilizante comercial na produção de capim-limão (Cymbopogon citratus (D.C.) Stapf). O experimento foi implantado em parcelas subdivididas com três repetições, colocando-se nas parcelas as densidades de plantio (33.333, 49.382, 55.555 e 111.111 plantas ha-1) e nas subparcelas as doses de biofertilizante (0; 20; 40 e 60 t ha-1). Foram realizadas nove colheitas em intervalos de 42 dias. Avaliou-se a sobrevivênci...

  6. Influencia de tres densidades de siembra y cuatro niveles de fertilización en la variedad de maíz INIA 612-Maselba

    OpenAIRE

    Walker Cubas Pérez; Christian Córdova Díaz

    2013-01-01

    El experimento se realizó el año 2008, en el Campo Experimental San Miguel de la EEA. San Roque del INIA - Loreto, con el objetivo de determinar el efecto de diferentes densidades de siembra y niveles de fertilización nitrogenada en el rendimiento de grano de la variedad de maíz amarillo duro, INIA 612 – MASELBA; en condiciones de suelos aluviales de restinga inundable. Se evaluaron tres densidades de siembra, 0,80m x 0,50m con 2 plantas por sitio (50 000 plantas/ha), 0,8m x 0,60m con 3 plant...

  7. Triglyceride/HDL ratio as a screening tool for predicting success at reducing anti-diabetic medications following weight loss.

    Directory of Open Access Journals (Sweden)

    Ghanshyam Palamaner Subash Shantha

    Full Text Available BACKGROUND AND OBJECTIVES: Intentional weight loss, by reducing insulin resistance, results in both better glycemic control and decreased need for anti-diabetic medications. However, not everyone who is successful with weight loss is able to reduce anti-diabetic medication use. In this retrospective cohort study, we assessed the predictive accuracy of baseline triglyceride (TGL/HDL ratio, a marker of insulin resistance, to screen patients for success in reducing anti-diabetic medication use with weight loss. METHODS: Case records of 121 overweight and obese attendees at two outpatient weight management centers were analyzed. The weight loss intervention consisted of a calorie-restricted diet (~1000Kcal/day deficit, a behavior modification plan, and a plan for increasing physical activity. RESULTS: Mean period of follow-up was 12.5 ± 3.5 months. By study exit, mean weight loss and mean HbA1c% reduction were 15.4 ± 5.5 kgs and 0.5 ± 0.2% respectively. 81 (67% in the study cohort achieved at least 1 dose reduction of any anti-diabetic medication. Tests for predictive accuracy of baseline TGL/HDL ratio ≤ 3 to determine success with dose reductions of anti-diabetic medications showed a sensitivity, specificity, positive predictive value, negative predictive value, area under the curve, likelihood ratio (LR + and LR-of 81, 83, 90, 70, 78, 4.8 and 0.2, respectively. Reproducibility of TGL/HDL ratio was acceptable. CONCLUSION: TGL/HDL ratio shows promise as an effective screening tool to determine success with dose reductions of anti-diabetic medications. The results of our study may inform the conduct of a systematic review using data from prior weight loss trials.

  8. The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.

    Directory of Open Access Journals (Sweden)

    Elisabeth M van Leeuwen

    Full Text Available Genome-wide association studies (GWAS have revealed 74 single nucleotide polymorphisms (SNPs associated with high-density lipoprotein cholesterol (HDL blood levels. This study is, to our knowledge, the first genome-wide interaction study (GWIS to identify SNP×SNP interactions associated with HDL levels. We performed a GWIS in the Rotterdam Study (RS cohort I (RS-I using the GLIDE tool which leverages the massively parallel computing power of Graphics Processing Units (GPUs to perform linear regression on all genome-wide pairs of SNPs. By performing a meta-analysis together with Rotterdam Study cohorts II and III (RS-II and RS-III, we were able to filter 181 interaction terms with a p-value<1 · 10-8 that replicated in the two independent cohorts. We were not able to replicate any of these interaction term in the AGES, ARIC, CHS, ERF, FHS and NFBC-66 cohorts (Ntotal = 30,011 when adjusting for multiple testing. Our GWIS resulted in the consistent finding of a possible interaction between rs774801 in ARMC8 (ENSG00000114098 and rs12442098 in SPATA8 (ENSG00000185594 being associated with HDL levels. However, p-values do not reach the preset Bonferroni correction of the p-values. Our study suggest that even for highly genetically determined traits such as HDL the sample sizes needed to detect SNP×SNP interactions are large and the 2-step filtering approaches do not yield a solution. Here we present our analysis plan and our reservations concerning GWIS.

  9. The Correlations Between Concentrations of Myeloperoxidase, Serum Amyloid-A Protein and Scretory Phospolipase A-2 with Proinflammatory HDL in Healthy Male Person

    Directory of Open Access Journals (Sweden)

    Marita Kaniawati

    2009-04-01

    Full Text Available BACKGROUND: Low-HDL cholesterol is a risk factor of CAD. Although levels of HDLC are within normal limit in some patients, they suffer CAD. These normal HDL-C levels might become pro-inflammatoric. This study is to measure the correlations between myeloperoxidase (MPO, serum amyloid-A (SAA protein, and secretoryphospholipase-A2 (sPLA2 with inflammatory status of HDL-C. METHODS: This was a cross-sectional study recruited 49 subjects with high HDL-C (>40 mg/dL and 31 subjects with low HDL-C (p<40 mg/dL. HDL-C was determined into antiinflammatory and proinflammatory based on levels of Apo A-1 and hs-CRP. Concentrations of MPO, SAA and s-PLA2 were measured by ELISA method. Levels of Apo A-1 was determined by immunoturbidimetric method. Multiple logistic regression analysis was done using inflammatory status of HDL-C as dependent variables and levels of MPO, SAA, sPLA2, ages, total cholesterol and triglycerides as independent variables. RESULTS: Patient’s age was 43.4+8.3 year, HDL-C was 43.1+9.5 mg/dL, Apo A-1 was 128.3+21.5 mg/dL, hs-CRP was 1.92+3.0 mg/dL. Concentrations of MPO, SAA and sPLA2 successively were 63.2+16.9 ng/mL, 7015.6+5021.1 ng/mL and 1340.2+406.3 pg/mL. Multiple logistic regression analysis showed that SAA is an independent predictor of pro-inflammatory status of HDL-C in high HDL-C group with prevalence ratio of 11.74 (95% CI: 2.51-54.84; p=0.002. In contrast, MPO and sPLA2 were not independent predictor with PR of 1.26 (95% CI: 0.30-5.23; p=0.75 and of 0.94 (95% CI: 0.23-3.91; p=0.93. CONCLUSIONS: SAA is an independent predictor of pro-inflammatory HDL-C even in subjects with high HDL-C. KEYWORDS: atherosclerosis, Apo A-1, serum amyloid A protein, secretory phospholipase A2, myeloperoxidase.

  10. MICROTOMOGRAFIA DE ALTA RESOLUÇÃO NO SETOR MINERAL

    Directory of Open Access Journals (Sweden)

    Daniel Uliana

    2014-07-01

    Full Text Available A técnica de microscopia por tomografia de raios X (MRX oferece uma capacidade única para análise de associações, morfologia e liberação de múltiplas fases através da aquisição direta de imagens tridimensionais de alta resolução. Trata-se de uma técnica de análise 3D não invasiva atualmente utilizada no setor mineral para caracterização de carvão, minerais industriais e de base, além de metais preciosos, complementando técnicas de microscopia já existentes como MLA e QEMSCAN. A técnica já é empregada há algum tempo na indústria do petróleo para a caracterização de tamanho e distribuição de poros, permitindo simular o fluxo de óleo em rochas reservatório. Além disso, a caracterização de poros em 3D permite a simulação de fluxo em processos de lixiviação. Requerendo pouca ou nenhuma preparação da amostra, comparativamente às técnicas de microscopia bi ou unidimensionais proporciona vantagens como a preparação muito mais ágil da amostra, aquisição direta de dados volumétricos, análise quantitativa em 3D e menor tempo de análise aliado a maior representatividade do material analisado. Particularmente em estudos de metais preciosos, tem-se um significativo aumento na probabilidade de detecção dos minerais de interesse. Recentes avanços com o emprego de dupla magnificação – projeção cônica aliada à utilização de lentes ópticas - possibilitam a aquisição de imagens com resolução submicrométrica com sensível melhoria no contraste entre as fases.

  11. Caracterização de ambientes com alta ocorrência natural de araticum (Annona crassiflora Mart. no Estado de Goiás Environmental characterization with high natural occurrence of araticum (Annona crassiflora Mart. in Goiás State

    Directory of Open Access Journals (Sweden)

    Marcos Antônio Machado Mesquita

    2007-04-01

    Full Text Available Foram selecionadas 14 áreas no Estado de Goiás, Brasil, com alta densidade da espécie araticum (Annona crassiflora Mart. e com menor ação antrópica possível. Cada área possuía 1,0ha, estando subdividida em quatro quadrantes (0,25ha. Foram levantados os dados relativos às características físicas das áreas, das plantas e dos solos (0-20cm. Os resultados demonstraram que o araticum tende a ocorrer em maior densidade em Latossolos não concrecionários dos chapadões, em formação de cerrado típico. A área basal total das plantas entre as áreas em estudo é influenciada positivamente pela concentração de Ca, Mg e K no solo. A densidade de plantas de araticum é influenciada negativamente pela concentração de Fe no solo. A distância geográfica entre as áreas não influenciou na densidade de plantas, na área basal média e na área basal total das plantas de araticum.14 areas were selected in the State of Goiás, Brazil, with high occurrence of the araticum specie (Annona crassiflora Mart. and with smaller human being action possible. Each area had 1ha, and these areas were subdivided in four quadrants of 0,25ha. The relative data of the areas, plants and soils physical characteristics (0-20cm was collected. The results demonstrated that the araticum tends to happen in larger density in "latossolos" in "concrecionários" of the plains in formation of typical cerrado. The total basal area of the araticum plants among the areas in study is influenced positively by the concentration of Ca, Mg and K in the soil. The density of araticum plants is influenced negatively by the concentration of iron in the soil. The geographical distance among the areas did not influence the density of plants, in the medium and total basal area of the araticum plants.

  12. Relación entre paraoxonasa, otros componentes de HDL y estado inflamatorio en hemodiálisis Relation between paraoxonase activity, other HDL components and inflammatory conditions in hemodialyzed patients

    Directory of Open Access Journals (Sweden)

    Ana Inés González

    2010-12-01

    Full Text Available La enfermedad renal crónica (ERC se asocia estrechamente con un estado pro-inflamatorio, aumento de lipoproteínas ricas en triglicéridos y disminución de HDL. La HDL contiene enzimas antioxidantes asociadas como la paraoxonasa (PON, cuya actividad en ERC se encuentra disminuida. Nuestro objetivo fue evaluar la relación entre la actividad de PON, apoA1, colesterol(col-HDL y Proteína C reactiva-altamente sensible (PCR-as como marcador de inflamación en pacientes en hemodiálisis. Se estudiaron n = 42 pacientes; edad, mediana (rango = 50 (25-67 años; sexo M/F = 22/20; antigüedad de hemodiálisis = 4.4 ± 0.5 años; índice de masa corporal (IMC = 23 ± 0.5 kg/m². Se obtuvo una muestra de sangre después de 12 h de ayuno y se determinaron los parámetros clásicos del perfil lipídico, se midieron los valores de apoproteínas A1 y B, PON a través de su actividad arilesterasa y PCR-as, la cual permitió dividir a los pacientes con PCR-as ≤ 1 (bajo riesgo, rango: 0.1 a 1.0 mg/l y > 1 mg/l (moderado y alto riesgo, 1.1 a 10.7 mg/l. Los niveles de triglicéridos, col-LDL y apoB no fueron diferentes entre los grupos. Los pacientes con PCR-as > 1 presentaron menor col-HDL (40 ± 2 mg/dl y apoA1 (118 ± 4 mg/dl que los pacientes con PCR-as ≤ 1 (50 ± 4 y 133 ± 5, respectivamente; p 1: 90.5 ± 24.0 μmol/ml.min que en PCR-as ≤ 1: 105.2 ± 18.0. Consecuentemente, se obtuvieron correlaciones inversas entre apoA1 y PCR-as, r = -0.381 p = 0.013 y entre PON y PCR-as, r = -0.32, p = 0.042. Además, el aumento de PCR-as correlacionó positivamente con el IMC, r = 0.318, p = 0.042. La disminución de col-HDL, apoA1 y PON en los individuos con mayor estado inflamatorio explicaría, en parte, el aumento de riesgo cardiovascular de estos pacientes, dado los efectos antiinflamatorios de la apoA1 y antioxidantes de la PON.Advanced Chronic Renal Disease (CKD is closely associated with a pro-inflammatory condition, with an increase in triglyceride

  13. Larvicultura do Mandi-amarelo Pimelodus maculatus Lacépède, 1803 (Siluriformes: Pimelodidae em Diferentes Densidades de Estocagem nos Primeiros Dias de Vida

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    Luz Ronald Kennedy

    2002-01-01

    Full Text Available Este trabalho foi realizado na Estação de Piscicultura de São Carlos (EPISCar, São Carlos, SC. O efeito da densidade de estocagem de Pimelodus maculatus na larvicultura foi avaliado em pós-larvas alimentadas diariamente com zooplâncton selvagem na proporção de 300 organismos/pós-larva/dia e submetidas aos seguintes tratamentos: T1 - 5 pós-larvas/litro; T2 - 15 pós-larvas/litro; T3 - 30 pós-larvas/litro. No terceiro e quinto dias de experimento, foi avaliada a taxa de sobrevivência. Decorridos três dias de experimento, não foi observada influência da densidade na sobrevivência, embora, no quinto dia de experimento, houvesse maior sobrevivência na menor densidade testada, com valores médios de sobrevivência final de T1 (35,6%, T2 (28,9% e T3 (20,6%. Os maiores valores de peso foram encontrados no tratamento de menor densidade, sendo os valores de comprimento semelhantes entre os tratamentos. O tratamento contendo 30 pós-larvas/L apresentou as menores taxas de sobrevivência e a maior produtividade final.

  14. Rentabilidade da cultura da macieira cultivar Gala em duas densidades de plantio Investment return for Gala apple cultivar using two planting densities

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    Carlos Leomar Kreuz

    2002-03-01

    Full Text Available O presente trabalho discute, com base em um estudo de caso, a viabilidade econômica de ampliar a densidade de plantio de macieiras cultivar Gala de 1.000 plantas por hectare para 3.378 plantas por hectare. Os resultados mostraram que a taxa interna de retorno não variou (próxima de 1,61% ao mês, independentemente da densidade utilizada, o que sugere o uso da menor densidade de plantio, uma vez que esta requer um menor volume de recursos financeiros. O custo unitário de produção também se mantém praticamente o mesmo ao se variar a densidade de plantio.The present study was carried out to analyse economic performances of Gala apple orchards at different planting densities. Two orchard densities (1,000 and 3,378 plants/ha were evaluated in an orchard near Fraiburgo, SC, Brazil. The use of both planting densities resulted in the same internal rate of return (approximately 1.6% a month. It is suggested to use a lower planting system, once it requires less capital. Unit cost also remained the same for both planting densities used in this study.

  15. Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro.

    Science.gov (United States)

    Hafiane, Anouar; Bielicki, John K; Johansson, Jan O; Genest, Jacques

    2015-01-01

    Apolipoprotein (apo) mimetic peptides replicate some aspects of HDL function. We have previously reported the effects of compound ATI-5261 on its ability to replicate many functions of native apo A-I in the process of HDL biogenesis. ATI-5261 induced muscle toxicity in wild type C57Bl/6 mice, increased CPK, ALT and AST and increase in triglyceride (Tg) levels. Aromatic phenylalanine residues on the non-polar face of ATI-5261, together with positively charged arginine residues at the lipid-water interface were responsible for these effects. This information was used to create a novel analog (CS-6253) that was non-toxic. We evaluated this peptide designed from the carboxyl terminus of apo E, in its ability to mimic apo A-I functionality. Our data shows that the lipidated particles generated by incubating cells overexpressing ABCA1 with lipid free CS-6253 enhances the rate of ABCA1 lipid efflux with high affinity interactions with native ABCA1 oligomeric forms and plasma membrane micro-domains. Interaction between ABCA1 and lipid free CS-6253 resulted in formation of nascent HDL-CS-6253 particles that are actively remodeled in plasma. Mature HDL-CS-6253 particles deliver cholesterol to liver cells via SR-BI in-vitro. CS-6253 significantly increases cholesterol efflux in murine macrophages and in human THP-1 macrophage-derived foam cells expressing ABCA1. Addition of CS-6253 to plasma dose-dependently displaced apo A-I from α-HDL particles and led to de novo formation of preβ-1 HDL that stimulates ABCA1 dependent cholesterol efflux efficiently. When incubated with human plasma CS-6253 was also found to bind with HDL and LDL and promoted the transfer of cholesterol from HDL to LDL predominantly. Our data shows that CS-6253 mimics apo A-I in its ability to promote ABCA1-mediated formation of nascent HDL particles, and enhances formation of preβ-1 HDL with increase in the cycling of apo A-I between the preβ and α-HDL particles in-vitro. These mechanisms are

  16. Reflexões acerca das nanotecnologias e as novas densidades técnicas-científicas-informacionais na agricultura

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    Soraia de Fátima Ramos

    2009-01-01

    Full Text Available As pesquisas sobre os potenciais usos das nanotecnologias no agronegócio suscitam enormes dúvidas sobre os reais benefícios ou malefícios em relação à adoção desta inovação. Daí a preocupação desta investigação em incluir as ciências humanas nos debates sobre a difusão das nanotecnologias. Pressupõe-se que, dada a efetiva incorporação dos novos produtos e processos nanotecnológicos, irá se configurar um aprofundamento das densidades técnicas-científicas- informacionais no espaço agrário brasileiro.

  17. EVALUACIÓN DE DENSIDADES DE PLANTACIÓN EN EL CULTIVO DE LA JAMAICA (Hibiscus sabdariffa L.)

    OpenAIRE

    Z. Terán; F. De Soto(Departamento de Sistemas Físicos, Químicos y Naturales, Universidad Pablo de Olavide, 41013 Sevilla, Spain)

    2004-01-01

    La investigación se llevó a cabo en el Instituto Nacional de Ciencias Agrícolas (INCA), en el verano del 2001, con el objetivo de comparar seis distancias de plantación en el cultivo de la Jamaica ( Hibiscus sabdariffa L.) y su influencia en los rendimientos y sus componentes por superficie para definir la densidad óptima. Las distancias empleadas fueron: 1.20x1.00m; 1.20x0.90m; 1.00x1.00m; 1.00x0.90m; 0.90x0.90m y 0.90x0.80m; a esos marcos de plantación correspondieron las siguientes densida...

  18. Força muscular e densidade mineral óssea em idosos eutróficos e desnutridos

    OpenAIRE

    Karla Helena Coelho Vilaça; Eduardo Ferriolli; Nereida Kilza da Costa Lima; Francisco José Albuquerque de Paula; Julio Sérgio Marchini; Julio Cesar Moriguti

    2011-01-01

    OBJETIVO: Este estudo teve como objetivo avaliar a associação do estado nutricional com a força muscular de preensão manual e a densidade mineral óssea em idosos do sexo masculino. MÉTODOS: Participaram do estudo 41 idosos do sexo masculino, sendo 20 eutróficos (peso: M=69,6, DP=8,4; índice de massa corporal: M=25,7, DP=2,2) e 21 desnutridos (peso: M=50,9, DP=6,1; índice de massa corporal: M=18,7, DP=1,8), classificados subjetivamente segundo a Mini Avaliação Nutricional. A avaliação antropom...

  19. El funcional de densidad local: una aplicacion a problemas de física de la materia condensada

    OpenAIRE

    Takeuchi, Noboru

    2012-01-01

    Se presenta una breve introducción al funcional de densidad local. Esta teoría permite la simplificación de las ecuaciones matemáticas que describen la estructura electrónica de los átomos, moléculas y sólidos. Durante muchos años se han buscado métodos que permitan el entendimiento de cómo funcionan los enlaces entre átomos. Con el nacimiento de la mecánica cuántica a principios de los años 1900 se sentaron las bases, formulando las leyes que rigen el comportamiento a nivel atómico. Sin emba...

  20. Densidade do solo, atributos químicos e sistema radicular do milho afetados pelo pastejo e manejo do solo

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    V. R. Silva

    2000-03-01

    Full Text Available A integração lavoura-pecuária é uma alternativa de renda dos produtores no sul do Brasil. Entretanto, o pisoteio animal e, ou, o preparo de solo podem compactá-lo, prejudicando o crescimento radicular e a produtividade das plantas. Estudaram-se os efeitos do pisoteio animal em regime de pastejo contínuo durante o inverno/primavera e do impacto do plantio direto e do preparo convencional de solo no estado de compactação, atributos químicos e distribuição radicular. Em Podzólico Vermelho-Amarelo de textura superficial franca, foi implantada uma pastagem de estação fria composta por aveia (Avena strigosa Schreb e azevém (Lolium multiflorum L.. A carga animal variou conforme o crescimento da pastagem. Em dezembro de 1996, foi implantada a cultura do milho (Zea mays L. para a produção de silagem, usando os seguintes tratamentos: plantio direto na área não pastejada, plantio direto após o pastejo, preparo convencional de solo na área não pastejada e preparo convencional de solo após pastejo. As avaliações apresentadas neste estudo são referentes ao terceiro ano de cultivo, no qual houve um período de pastejo de 107 dias. Aos 45 dias da emergência do milho, foram abertas trincheiras (100 x 40 cm para visualizar a distribuição do sistema radicular e coletar amostras de solo, a cada 5 cm, para caracterização química e determinação da densidade do solo e de raízes. Ao longo do perfil (0-40 cm, o desenho da distribuição de raízes indicou maior quantidade de raízes no preparo convencional de solo, concordando com os resultados de densidade de raízes. O pisoteio animal não teve efeito sobre as características físicas, possivelmente pelo fato de o resíduo da pastagem permanecer próximo a 1,0 Mg ha-1 de matéria seca. A densidade do solo no plantio direto, na camada de 5-10 cm, foi de 1,41 Mg m-3, tanto na área pastejada como na não pastejada. No preparo convencional de solo, esses valores foram de 1,15 Mg m-3

  1. Densidad del Mono aullador Alouatta seniculus (Linnaeus, 1766 Mammalia: primates en el arroyo coloso, Departamento de Sucre, Colombia

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    Fajardo Patiño Alirio

    1996-12-01

    Full Text Available Nueve manadas de Alouatta seniculus, fueron estudiadas a lo largo de tres meses y medio, entre Mayo y Agosto de 1983. Se tomaron en cuenta aspectos relativos al estado y densidad poblacional en el Arroyo Colosó, Departamento de Sucre. Se establece una relación de los datos obtenidos y procesados en este trabajo con los suministrados por otros autores en estudios similares con la misma especie y en diferentes lugares.Nine troops of Alouatta seniculus, were studied for a period of three and half months betwen May and August of 1983. Relevant facts of the condition and population density in the Colosó stream, located in Sucre Deparment, were taken. A relation is stablished among the facts obtained and processed in this investigation with facts provided by another authors in similar studies with the same specie in different locations.

  2. AVALIAÇÃO AGROTECNOLÓGICA E DO CICLO DE VARIEDADES DE ABACAXIZEIRO, EM DUAS DENSIDADES, EM VOTUPORANGA (SP

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    ADEMAR SPIRONELLO

    1997-01-01

    Full Text Available Desenvolveu-se um experimento, no Noroeste paulista, em duas densidades de cultivo, com o objetivo de estudar as variedades de abacaxizeiro existentes no Estado, com potencial produtivo e de qualidade de fruto, e muito mais resistentes à fusariose que as duas comerciais, a saber: Smooth Cayenne, Pérola (únicas cultivadas comercialmente no Brasil e ambas muito suscetíveis à fusariose, Rondon e Turi Verde. As densidades de cultivo foram D1 = 60.606 plantas/hectare - linhas duplas de 30 x 30 x 80 cm, e D2 = 35.714 plantas/hectare - 40 x 40 x 100 cm. Efetuou-se o experimento em parcelas subdivididas, com as principais (densidades dispostas em blocos ao acaso com seis repetições. As subparcelas (variedades constaram de duas linhas duplas com doze plantas úteis. Mediram-se, em cada planta, os períodos de emissão natural da inflorescência, os tempos decorridos desde essa emissão até o início e o término de florescimento e, deste último, até a colheita. Determinaram-se as dimensões e a massa dos frutos e das coroas, o número de mudas produzidas e, na polpa dos frutos, o grau Brix, a acidez, o pH, o teor de vitamina C e de textura. A variedade Smooth Cayenne apresentou maior produtividade de frutos (47% e maior teor de sólidos solúveis da polpa (30% que a média de `Pérola' e `Rondon'. Os resultados indicam a viabilidade de utilização da `Rondon' no cultivo comercial, como opção para substituir a `Pérola'. O aproveitamento da soca das variedades foi viável apenas na `Rondon', que mostrou frutos precoces e pouco menores que os da primeira produção. A maior densidade de cultivo proporcionou, na média das variedades, maior produtividade de frutos (56%, menor massa média de frutos e de coroas (10% e menor número de filhotes por planta (14%.A field trial has been carried out at the Northwestern region of São Paulo State, aiming at studying four pineapple cultivars (Smooth Cayenne, Pérola, Rondon and Turi Verde in two plant

  3. On the synonymy of Stictocephala alta (Walker and Thelia constans Walker (Hemiptera: Membracidae Sobre a sinonímia de Stictocephala alta (Walker e Thelia constans Walker (Hemiptera: Membracidae

    Directory of Open Access Journals (Sweden)

    Gabriel Simões de Andrade

    2008-03-01

    Full Text Available This paper deals with the synonymy of Ceresa alta Walker, 1851, now Stictocephala alta, and its junior synonym, Thelia constans Walker, 1851. Notes on Stictocephala bisonia Kopp & Yonke, 1977 are also presented.São abordadas a sinonímia de Ceresa alta Walker, 1851, atualmente Stictocephala alta, e de Thelia constans Walker, 1851, como seu sinônimo júnior. Comentários sobre Stictocephala bisonia Kopp & Yonke, 1977 são apresentados também.

  4. Variabilidade Espacial e Densidade Amostral da Suscetibilidade Magnética e dos Atributos de Argissolos da Região de Manicoré, AM

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    Ivanildo Amorim de Oliveira

    2015-06-01

    Full Text Available A dificuldade em encontrar informações recentes sobre o comportamento espacial dos atributos dos solos na Região Amazônica tem sido preocupação de muitos pesquisadores. Em razão da grande dificuldade e dos custos para avaliar os atributos dos solos, têm-se utilizados métodos alternativos para predição de atributos do solo como a suscetibilidade magnética. Sendo assim, o objetivo deste trabalho foi avaliar a variabilidade espacial da suscetibilidade magnética (SM, os atributos físicos e químicos e determinar a densidade amostral de coleta em Argissolo Vermelho sob floresta nativa, Terra Preta Arqueológica (TPA sob cultivo, e pastagem na região de Manicoré, Amazonas. Nessas áreas, foram estabelecidas malhas com dimensão de 70 × 70 m e demarcados pontos nessas malhas, espaçados a cada 10 m, totalizando 64 pontos. Esses pontos foram georreferenciados e, em seguida, realizaram-se as coletas de solo em cada ponto da malha nas camadas de 0,00-0,20 e 0,40-0,60 m para determinar atributos químicos (pH em água, matéria orgânica, P, K, Ca, Mg e acidez potencial, físicos (textura, macroporosidade, microporosidade, diâmetro médio ponderado, densidade do solo e densidade de partículas e suscetibilidade magnética. Os dados foram submetidos à análise de variância, e as médias, comparadas pelo teste de Tukey a 5 %. Realizou-se a estatística descritiva. Para caracterizar a variabilidade, fez-se a geoestatística com uso de semivariograma escalonado. O alcance dos semivariogramas escalonados foi utilizado para determinar a densidade amostral mínima de coleta para estimar a variabilidade dos atributos estudados. As áreas de TPA e pastagem apresentaram maior variabilidade, apresentando menor alcance e maior densidade amostral (cinco pontos por hectare. A SM apresentou comportamento espacial similar aos atributos físicos e químicos estudados, sendo a densidade amostral da SM próxima à densidade amostral dos atributos nos

  5. Influencias de la densidad y podas sobre la producción de Pinus taeda L. a los 7 años de edad.

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    Rubén Costas

    2010-08-01

    Full Text Available En un ensayo con 3 niveles de densidad y 12 tratamientos de poda, se evaluaron los efectos de la densidad, la altura de poda, el número de levantes de poda y la interacción entre la densidad y las podas sobre la producción de la masa de Pinus taeda L. a los 7 años de edad. Las variables evaluadas fueron el diámetro a la altura de pecho medio (DAP, la altura media, el volumen individual, el volumen por unidad de superficie, el área basal, el diámetro máximo sobre muñón (DMSM, el coeficiente de forma de Girard (CFG, el diámetro de ramas (DRBC y el ángulo de inserción de las ramas (ARBC en la base de la copa. En los tratamientos con mayor densidad de plantación se observaron mayores volúmenes por unidad de superficie, área basal y CFG que en los tratamientos con menor densidad. Estos produjeron mayores DAP, volúmenes individuales, DMSM, DRBC y ARBC que los tratamientos con mayores densidades. Los tratamientos con menores alturas finales de poda produjeron mayores DAP, volúmenes individuales, área basal y volúmenes por unidad de superficie que los tratamientos con mayores alturas de poda. Los menores DMSM se obtuvieron con alturas finales de poda de 3,30 m y 4,40 m realizadas a los 4 años de edad y los mayores DMSM ocurrieron al no efectuarse podas a los 5 años hasta 5,50 m y 6,60 m. No se encontraron diferencias significativas entre los valores medios de DRBC, ARBC y CFG producidos por los 12 tratamientos de poda. La interacción entre densidad y los tratamientos de poda no fue significativa para ninguna de las variables respuestas.

  6. Molecular dynamics simulation of human serum paraoxonase 1 in DPPC bilayer reveals a critical role of transmembrane helix H1 for HDL association.

    Science.gov (United States)

    Patra, Mahesh Chandra; Rath, Surya Narayan; Pradhan, Sukanta Kumar; Maharana, Jitendra; De, Sachinandan

    2014-01-01

    Serum paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-bound mammalian enzyme exhibiting antiatherosclerotic activity. Despite years of research, an accurate model for the binding interaction between PON1 and HDL has not been established. However, it is reported that anchoring of PON1 to HDL is mainly governed by an N-terminal alpha helix H1 and another short helix H2. Here, we studied the molecular association of full-length human PON1 (huPON1) with a HDL-mimetic dipalmitoylphosphatidylcholine (DPPC) bilayer using homology modeling and molecular dynamics simulations. Our results indicate that H1 is the highly dynamic part of huPON1, showing clockwise rotation of up to 30° within the DPPC bilayer. However, without phospholipid molecules, H1 experiences helical distortions, illustrating an incompatible HDL-anchoring conformation. Snorkeling interactions of K3, R18, and R27 together with aromatic locks formed by Y187, Y190, W194, and W202 are highly essential for anchoring of huPON1 to HDL's surface. Molecular mechanics/Poisson-Boltzmann solvent-accessible surface area (MM/PBSA) binding free energy calculation revealed that H1 displays greater binding affinity towards lipid molecules compared with H2 and H3, suggesting that H1 is the most probable HDL-binding domain of PON1. Binding free energy decomposition showed that K3, R18, and R27 interact with polar headgroups of DPPC membrane through electrostatic interaction. Moreover, Y187, Y190, W194, and W202 interact with DPPC lipids mainly through van der Waals interaction. Taken together, these results show that the transmembrane helix H1 along with the interfacial positively charged and aromatic resides were crucial for PON1's association with HDL particle. The current study will be useful towards understanding the antiatherosclerotic and bioscavenging properties of this promiscuous enzyme. PMID:24297451

  7. Implementation of stable isotopes lipoprotein kinetic studies: effects on HDL metabolism of a Mediterranean type diet rich in MUFAs from virgin olive oil.

    OpenAIRE

    Uliaque Cugat, Katia

    2007-01-01

    The anti-atherogenic effects ascribed to a Mediterranean-type diet rich in monounsaturatedfatty acids (MUFAs) from virgin olive oil are due, partly, to an increase in, or maintenance of,plasma concentrations of high density lipoprotein (HDL) cholesterol. However, the underlyingmechanisms that may explain these concentrations are not well characterised, to-date.Apolipoprotein (apo) A-I (apoA-I) is the major HDL apo and its kinetic parameters, such asproduction rate and catabolic rate, reflect ...

  8. Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Plasma CETP and Increases Apolipoprotein AI Levels Without Improving the Cholesterol Efflux Properties of HDL

    OpenAIRE

    Wang, Yanan; Snel, Marieke; Jonker, Jacqueline T; Hammer, Sebastiaan; Lamb, Hildo J.; de Roos, Albert; Meinders, A. Edo; Pijl, Hanno; Romijn, Johannes A.; Johannes W A Smit; Jazet, Ingrid M.; Rensen, Patrick C N

    2011-01-01

    OBJECTIVE Using a mouse model for human-like lipoprotein metabolism, we observed previously that reduction of the hepatic triglyceride (TG) content resulted in a decrease in plasma cholesteryl ester transfer protein (CETP) and an increase in HDL levels. The aim of the current study was to investigate the effects of prolonged caloric restriction in obese patients with type 2 diabetes mellitus, resulting in a major reduction in hepatic TG content, on plasma CETP and HDL levels. RESEARCH DESIGN ...

  9. Niche conservatism of Eulophia alta, a trans-Atlantic orchid species

    Directory of Open Access Journals (Sweden)

    Marta Kolanowska

    2014-03-01

    Full Text Available The genus Eulophia embraces over 230 species distributed through the tropical and subtropical Africa, Asia, Australia and the Americas. In Neotropics it is represented by a sole species – E. alta. The aim of the presented study was to evaluate the difference between ecological niches occupied by American and African populations of this species based on the ecological niche modeling. The similarity between the glacial and present niches occupied by E. alta was calculated and the factors limiting the species occurrence were identified. Areas of seasonal tropical forest, tropical savanna and woodland served as refugia for the studied species during last glacial maximum and they were more widespread in Neotropics than in Africa. No significant niche shift after last glacial maximum was observed. The distribution of E. alta in its whole range is restricted mainly by temperature seasonality. The differences in the niches occupied by African and Neotropical populations of E. alta suggest preglacial disjunction of the species range and independent adaptation of both groups. Despite the significant range disjunction of E. alta the species is characterized by relatively high degree of niche conservatism.

  10. ENFERMEDADES Y COMPONENTES DE RENDIMIENTO EN LÍNEAS DE FRÉJOL BAJO TRES DENSIDADES DE SIEMBRA

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    Felipe Rafael Garc\\u00E9s-Fiallos

    2014-01-01

    Full Text Available El objetivo fue evaluar las enfermedades, el rendimiento y sus componen - tes en líneas de fréjol bajo tres distanciamientos de siembra. El trabajo se realizó durante la época seca del año 2011, en la Universidad Técnica Estatal de Quevedo (UTEQ, Quevedo, Ecuador. Se determinó la incidencia y severidad de la roya ( Uromyces appendiculatus y mustia hilachosa ( Rizoctonia solani en los estadíos R7 (formación en legumbres y R8 (llenado de legumbres, y después de la cosecha la incidencia de las pudriciones radiculares ( Macrophomina phaseolina y R. solani . Los componentes de rendimiento (número de nudos, legumbres, granos, granos por legumbre, legumbres estériles y granos por planta y peso de granos. Se empleó un Diseño de Bloques Completos al Azar (DBCA con doce tratamientos y tres repeticiones, con arreglo factorial de 4 (líneas promisorias x 3 (planta/m. Para la comparación entre las medias de los tratamientos se empleó la prueba de Tukey al 5% de probabilidad del error. Las líneas promisorias de fréjol EVG 06-103 y SER-03 presentaron menor intensidad de enfermedades. Un aumento en la densidad poblacional causó un acrecentamiento en la intensidad de la roya. Las líneas SER-08 y SER-03 obtuvieron la mayor productividad según la mayoría de componentes de rendimiento y peso de granos. Finalmente, el incremento de la densidad de plantas promovió reducción significativa en el número de legumbres, granos y granos por legumbre por planta, contrario al aumento observado en el peso de granos

  11. Implications of the obesity epidemic for lipid-lowering therapy: Non-HDL cholesterol should replace LDL cholesterol as the primary therapeutic target

    Directory of Open Access Journals (Sweden)

    Michel R Hoenig

    2008-05-01

    Full Text Available Michel R HoenigRoyal Brisbane and Women’s Hospital, Herston, Queensland, AustraliaAbstract: Obesity, metabolic syndrome and diabetes are conditions with increasing prevalence around the world. Cardiovascular risk in diabetics is often so high as to overlap with event rates observed in those with established coronary disease and this has lead to diabetes being classified as a coronary risk equivalent. However, despite the elevated risk of cardiovascular events associated with diabetes and the metabolic syndrome, these patients often have normal low density lipoprotein (LDL cholesterol despite frequent increases in apolipoprotein B, triglycerides and nonhigh density lipoprotein (HDL cholesterol. In contrast to LDL cholesterol, non-HDL cholesterol represents cardiovascular risk across all patient populations but is currently only recommended as a secondary target of therapy by the ATP III report for patients with hypertriglyceridemia. This article provides an overview of the studies that shown non-HDL cholesterol to be superior to LDL cholesterol in predicting cardiovascular events and presents the case for non-HDL cholesterol being the more appropriate primary target of therapy in the context of the obesity pandemic. Adopting non-HDL cholesterol as the primary therapeutic target for all patients will conceivably lead to an appropriate intensification of therapy for high risk patients with low LDL cholesterol.Keywords: obesity, coronary artery disease, non-HDL cholesterol, LDL cholesterol, metabolic syndrome, diabetes

  12. HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function[S

    Science.gov (United States)

    Berisha, Stela Z.; Brubaker, Greg; Kasumov, Takhar; Hung, Kimberly T.; DiBello, Patricia M.; Huang, Ying; Li, Ling; Willard, Belinda; Pollard, Katherine A.; Nagy, Laura E.; Hazen, Stanley L.; Smith, Jonathan D.

    2015-01-01

    HDL functions are impaired by myeloperoxidase (MPO), which selectively targets and oxidizes human apoA1. We previously found that the 4WF isoform of human apoA1, in which the four tryptophan residues are substituted with phenylalanine, is resistant to MPO-mediated loss of function. The purpose of this study was to generate 4WF apoA1 transgenic mice and compare functional properties of the 4WF and wild-type human apoA1 isoforms in vivo. Male mice had significantly higher plasma apoA1 levels than females for both isoforms of human apoA1, attributed to different production rates. With matched plasma apoA1 levels, 4WF transgenics had a trend for slightly less HDL-cholesterol versus human apoA1 transgenics. While 4WF transgenics had 31% less reverse cholesterol transport (RCT) to the plasma compartment, equivalent RCT to the liver and feces was observed. Plasma from both strains had similar ability to accept cholesterol and facilitate ex vivo cholesterol efflux from macrophages. Furthermore, we observed that 4WF transgenic HDL was partially (∼50%) protected from MPO-mediated loss of function while human apoA1 transgenic HDL lost all ABCA1-dependent cholesterol acceptor activity. In conclusion, the structure and function of HDL from 4WF transgenic mice was not different than HDL derived from human apoA1 transgenic mice. PMID:25561462

  13. Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice.

    Science.gov (United States)

    Pitman, Wendy A; Korstanje, Ron; Churchill, Gary A; Nicodeme, Edwige; Albers, John J; Cheung, Marian C; Staton, Megan A; Sampson, Stephen S; Harris, Stephen; Paigen, Beverly

    2002-01-01

    To investigate the quantitative trait loci (QTL) regulating plasma cholesterol, the female progeny of an (SMxNZB/ B1NJ)xNZB/B1NJ backcross were fed an atherogenic diet. After 18 wk, plasma total cholesterol and high-density lipoprotein cholesterol (HDL-C) was measured. HDL-C concentrations were greater in NZB than in SM mice. For standard chow-fed mice, QTL were found near D5Mit370 and D18Mit34. For mice fed an atherogenic diet, a QTL was found near D5Mit239. The QTL for chow-fed and atherogenic-fed mice on chromosome 5 seem to be two different loci. We used a multitrait analysis to rule out pleiotropy in favor of a two-QTL hypothesis. Furthermore, the HDL-C in these strains was induced by the high-fat diet. For inducible HDL-C, one significant locus was found near D15Mit39. The gene for an HDL receptor, Srb1, maps close to the HDL-C QTL at D5Mit370, but the concentrations of Srb1 mRNA and SR-B1 protein and the gene sequence of NZB/B1NJ and SM/J did not support Srb1 as a candidate gene. With these QTL, we have identified chromosomal regions that affect lipoprotein profiles in these strains. PMID:12006675

  14. Evaluation of alcohol outlet density and its relation with violence Avaliação da densidade de pontos de vendas de álcool e sua relação com a violência

    Directory of Open Access Journals (Sweden)

    Ronaldo Laranjeira

    2002-08-01

    , buscou-se investigar a disponibilidade de bebidas alcoólicas em uma região densamente povoada e melhorar o entendimento sobre o acesso a essa substância, para que ações preventivas futuras possam beneficiar-se dessas informações. MÉTODOS: O estudo foi realizado em uma região do Município de São Paulo, SP, Brazil. Foram treinados 24 entrevistadores, moradores da região, para fazerem a coleta de dados. Foi selecionada uma área de 19 ruas, cobrindo uma distância de 3.7 km. Foi feito um perfil de cada ponto de venda de bebidas alcoólicas dessa região. RESULTADOS: Foram registrados 107 pontos de venda de álcool. O número de outras propriedades nessa região foi de 1.202. Duas medidas de densidade de pontos de venda podem ser calculadas: número de pontos de venda por kilômetro de rua (29 pontos/km e proporção de todas as propriedades de venda de álcool (1 em 12. CONCLUSÕES: Comparado a estudos internacionais principalmente de países desenvolvidos, a área estudada tem a mais alta densidade de pontos de vendas de álcool registrada na literatura médica. As informações sobre as vendas de álcool e os locais de venda contribuíram para melhorar o entendimento do acesso ao álcool na região estudada. Ações preventivas futuras poderão beneficiar-se dessas informações.

  15. DOSES DE NITROGÊNIO E DENSIDADES DE PLANTAS COM E SEM UM REGULADOR DE CRESCIMENTO AFETANDO O TRIGO, CULTIVAR OR-1 NITROGEN DOSES AND PLANT DENSITIES WITH AND WITHOUT A GROWTH REGULATOR AFFECTING WHEAT, CULTIVAR OR-1

    Directory of Open Access Journals (Sweden)

    Jeferson Zagonel

    2002-02-01

    Full Text Available Doses de nitrogênio e elevadas populações de plantas são utilizadas visando a obtenção de altas produtividades em trigo. Porém, estes fatores podem promover o acamamento das plantas, especialmente para as cultivares de porte médio ou alto. O uso de produtos que reduzem a estatura das plantas pode minimizar este problema. Visando avaliar o efeito do regulador de crescimento trinexapc-ethyl em diferentes populações de plantas e doses de nitrogênio, na cultivar de trigo OR-1, instalou-se um experimento na Fazenda Escola "Capão da Onça", da Universidade Estadual de Ponta Grossa, em Ponta Grossa, PR, no ano de 1999. O delineamento experimental foi blocos ao acaso em esquema fatorial 2 x 3 x 4, em quatro repetições. Os vinte e quatro tratamentos constaram da aplicação de 125 g i.a./ha de trinexapac-ethyl e testemunha; densidades de 55, 75 e 112 plantas/m no espaçamento de 0,17m entre fileiras e doses de 0, 45, 90 e 135kg/ha de nitrogênio em cobertura. A aplicação do trinexapac-ethyl resultou em plantas com entre-nós mais curtos; em aumento do número de espigas/m e da produtividade. Com o aumento da dose de nitrogênio, ocorreu aumento da estatura das plantas, do número de espigas/m e da produtividade. Com o aumento da densidade de plantas, o diâmetro do caule, a massa seca das plantas e o número de grãos por espiga diminuíram mas o número de espigas/m e o peso de mil grãos aumentaram, sem afetarem a produtividade. Não ocorreu acamamento em nenhum dos tratamentos.Elevated nitrogen rates and high plant populations are adopted with the purpose of achieving high wheat yields. However, these factors may promote the lodging of the plants, especially for the medium and tall height cultivars. The utilization of products which reduce plant height could minimize this problem. With the aim of evaluating the effects of a growth regulator on different plant populations and nitrogen rates for the wheat cultivar OR-1, an experiment was

  16. Amide-linked Ethanolamine Conjugate of Gemfibrozil as a Profound HDL Enhancer: Design, Synthesis, Pharmacological Screening and Docking Study.

    Science.gov (United States)

    Rai, Himanshu; Dhaneshwar, Suneela S

    2015-01-01

    Elevated concentration of any or all types of lipids in the plasma including hypertriglyceridemia and hypercholesterolemia leads to atherosclerotic cardiovascular disease. Effective medication needs multiple drug therapy as recommended cholesterol and triglyceride levels are difficult to achieve by monotherapy and frequently require the use of more than one lipid-lowering medication. Gemfibrozil lowers plasma triglyceride-rich lipoproteins mainly VLDL and increases HDL. It is associated with short plasma half-life (1.5h) and GIT distress on long term use. In a study it was found that ethanolamine decreases serum cholesterol, especially VLDL cholesterol and LDL cholesterol in rats fed an HF/HC diet. In the present work, we thought of exploring the effect of co-drug of gemfibrozil with ethanolamine (GE-I) as a potential combination therapy for the management of mixed hyperlipidemia. Synthesis of GE-I was effected by CDI coupling. Structure was confirmed spectrally. Interestingly kinetic studies revealed that GE-I resisted chemical and enzymatic hydrolysis. In tritoninduced hyperlipidemia, significant lowering of serum lipid levels was observed. The hallmark of GEI was its profound effect on HDL level which was raised above the normal level by 15%. Docking study also supported modulatory effect of GE-I (docking score -7.012) on PPAR-α which was comparable to docking score of gemfibrozil (-9.432). These preliminary observations prompt us to consider GE-I as a novel, serendipitous, hybrid anti-hyperlipidemic new chemical entity which needs be studied extensively to prove it as an HDL enhancing anti-hyperlipidemic agent. PMID:26285608

  17. Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Shu Meguro

    2014-01-01

    Full Text Available Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6%. Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was 71.2±22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r=−0.450, P<0.01, triglyceride (r=0.445, P<0.01, and high sensitive C-reactive protein (r=0.316, P<0.01 but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=−0.411, P<0.01 and high sensitive C-reactive protein (β=0.193, P<0.05. Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.

  18. Potential role of the interaction between equine estrogens, low-density lipoprotein (LDL and high-density lipoprotein (HDL in the prevention of coronary heart and neurodegenerative diseases in postmenopausal women

    Directory of Open Access Journals (Sweden)

    Gerulath Alan

    2003-06-01

    Full Text Available Abstract Background An inverse relationship between the level of high-density lipoprotein (HDL and coronary heart disease (CHD has been reported. In contrast, oxidized HDL (oHDL has been shown to induce neuronal death and may play an important role in the pathogenesis of CHD. In the present study we have investigated a: the effect of various equine estrogens on HDL oxidation, b: the inhibition of LDL oxidation by HDL and c: the effect of these estrogens on LDL oxidation in the presence of HDL. Results All 11 equine estrogens tested protected the HDL from oxidation in a concentration dependant manner. Equilenin, 17β-dihydroequilenin, and 17α-dihydroequilenin (Δ6–8-estrogens were found to be the most potent inhibitors of HDL oxidation. Some of the novel ring B unsaturated estrogens were 2.5 to 4 times more potent inhibitors of HDL oxidation than 17β-estradiol. HDL was found to delay LDL oxidation. The protection of LDL oxidation by HDL is enhanced by the addition of estrogen, with equilenin being again more potent than 17β-estradiol. Conclusions Equine estrogens can differentially inhibit the oxidation of HDL with the Δ6–8-estrogens being the most potent antioxidants. The ability of estrogens to enhance HDL's antioxidant activity is to our knowledge the first report of an interaction of estrogen with HDL that results in the delay or inhibition of LDL oxidation. This may be another mechanism by which estrogens may reduce the risk of CHD and neurodegenerative diseases in healthy and younger postmenopausal women.

  19. Stress responses of juvenile matrinxã (Brycon amazonicus after transport in a closed system under different loading densities Respostas de estresse de matrinxã (Brycon amazonicus juvenil após transporte em sistema fechado sob diferentes densidades de carga

    Directory of Open Access Journals (Sweden)

    Janessa Sampaio de Abreu

    2008-08-01

    , a temperatura esteve em torno de 32°C, pH 6,5-6,78, a amônia total foi de 1,09-1,7mg L-1, a amônia não-ionizada foi de 3,58-9,33 x 10³mg L-1 e alcalinidade 134-165mg CaCO3 L-1. O cortisol plasmático e a glicose sanguínea aumentaram após o transporte nos peixes em todas as densidades ensaiadas, voltando aos valores controle 24h depois. Os valores de osmolaridade não mudaram logo após o transporte, mas aumentaram 24h depois de modo igual em todas as densidades. O cloreto plasmático diminuiu na chegada, de modo inversamente proporcional à densidade de carga. O hematócrito diminuiu 24h depois da chegada dos peixes, em todas as densidades testadas, mas não houve diferença no número de eritrócitos. Não houve mortalidade até uma semana após o transporte. O matrinxã mostrou ser uma espécie tolerante a altas densidades de carga em embalagens para transporte além de suportar baixos níveis de oxigênio na água.

  20. The TG/HDL-C Ratio Might Be a Surrogate for Insulin Resistance in Chinese Nonobese Women

    OpenAIRE

    2014-01-01

    Obejective. To examine the discriminatory power of triglyceride (TG) and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) for insulin resistance (IR) in a normoglycaemic Chinese population. Methods. The data were collected from 711 individuals. The normoglycaemic individuals were eventually included in the study (n = 533, age: 62.8 ± 6.6 years, male: 56.8%), who were with a fasting plasma glucose < 6.1 mmol/L and without a history of diabetes. IR was defined as the upper ...

  1. EFEK PEMBERIAN SUSU SAPI BUBUK TERHADAP KADAR SERUM HDL (HIGH DENSITY LIPOPROTEIN PADA TIKUS PUTIH (Rattus norvegicus GALUR WISTAR MODEL DIABETES MELITUS TIPE 2

    Directory of Open Access Journals (Sweden)

    Zakia Umami

    2015-05-01

    Full Text Available ABSTRACTThe purpose of this study was to determine the cow’s milk powder to increased serum levels of High Density Lipoprotein (HDL of white male rat model with diabetes mellitus type 2. The design of this study was a post-test control group study conducted in 30 male rats which randomly divided into five groups. Negative control group was the group of rats which fed normally, the positive control group was induced by streptozotocin (STZ without given cow’s milk, group P1, P2, P3 were given a normal diet and cow’s milk 0.9; 1.8, and 2.7 g orally every day. The results of this study were the levels of HDL in K(-=44.22 mg/dl, K(+=47.45 mg/dl, P1=56.56 mg/dl, P2=51.82 mg/dl, and P3=59.45 mg/dl. The conclusion was the milk powder was not significantly increase levels of HDL (p>0.05. More longer intervention was suggested for further research to get more significant of HDL level on type 2 diabetes mellitus.Keywords: HDL serum level, high fat diet, milk powder, streptozotocinABSTRAKTujuan penelitian ini adalah menganalisis pengaruh pemberian susu sapi bubuk terhadap peningkatan kadar serum High Density Lipoprotein (HDL tikus putih (Rattus norvegicus berjenis kelamin jantan model diabetes melitus (DM tipe 2. Penelitian ini menggunakan desain penelitian post test control group dengan 30 ekor tikus dibagi secara acak menjadi lima kelompok. Kelompok K(- adalah tikus yang diberi pakan normal, kelompok K(+ diinduksi dengan streptozotocin (STZ tanpa diberi susu, kelompok P1 sampai P3 diberi diet normal dan susu 0,9; 1,8, dan 2,7 g secara oral setiap hari. Hasil penelitian menunjukkan kadar HDL pada K(-=44,22 mg/dl, K(+=47,45 mg/dl, P1=56,56 mg/dl, P2=51,82 mg/dl, dan P3=59,45 mg/dl. Susu sapi bubuk mampu meningkatkan kadar HDL tikus model DM tipe 2 akan tetapi tidak signifikan (p>0,05. Perlu dilakukan penelitian lebih lanjut dengan waktu lama penelitian yang berbeda sehingga bisa berdampak yang lebih signifikan untuk kadar HDL pada DM tipe 2.Kata kunci

  2. Consumo energético de sistemas de computación de altas prestaciones

    OpenAIRE

    Balladini, Javier; Morán, Marina; Rozas, Claudia; De Giusti, Armando Eduardo; Suppi, Remo; Rexachs del Rosario, Dolores; Luque, Emilio

    2015-01-01

    En la última década, el consumo energético ha dirigido el diseño de todos los sistemas de cómputo, desde dispositivos móviles a los cuales cada vez se le piden más prestaciones que deben ser soportadas por una pequeña batería, hasta los sistemas de Cómputo de Altas Prestaciones (HPC, de High Performance Computing), objeto de nuestro interés, los cuales consumen enormes cantidades de energía. Esta alta demanda energ ética tiene serias consecuencias financieras, medioambientales, y en muchos c...

  3. Papel de la enfermería en las hemorragias digestivas altas en urgencias y emergencias

    OpenAIRE

    Ibáñez García, Patricia

    2015-01-01

    La hemorragia digestiva alta es la complicación gastroenterológica más importante. Está delimitada por el esfínter esofágico superior y el ángulo de Treitz, es decir, es aquella que se produce en esófago, estómago o duodeno. El objetivo de esta revisión bibliográfica es conocer cuál es el papel que ejerce la enfermería ante una hemorragia digestiva alta en las emergencias extrahospitalarias y urgencias hospitalarias. Se diferencian dos tipos de hemorragias según la causa que las produzc...

  4. Estudo da miscibilidade das misturas de PHB e PLA, com um PHB de alta polidispersividade

    Directory of Open Access Journals (Sweden)

    Wagner Mauricio Pachekoski

    2015-02-01

    Full Text Available Neste trabalho, foi estudada a miscibilidade de misturas de um PHB constituído de frações de alta e baixa massa molar com um PLA de alta massa molar. Os materiais extrudados foram analisados pelas técnicas de calorimetria exploratória diferencial (DSC, espectroscopia dielétrica (DE e análises dinâmico-mecânicas (DMA. A partir dos resultados observou-se o distinto comportamento cristalino das frações de PHB, assim como a miscibilidade parcial do PLA com o PHB de baixa massa molar.

  5. Estudo da miscibilidade das misturas de PHB e PLA, com um PHB de alta polidispersividade

    OpenAIRE

    Wagner Mauricio Pachekoski; Carla Dalmolin; José Augusto Marcondes Agnelli

    2015-01-01

    Neste trabalho, foi estudada a miscibilidade de misturas de um PHB constituído de frações de alta e baixa massa molar com um PLA de alta massa molar. Os materiais extrudados foram analisados pelas técnicas de calorimetria exploratória diferencial (DSC), espectroscopia dielétrica (DE) e análises dinâmico-mecânicas (DMA). A partir dos resultados observou-se o distinto comportamento cristalino das frações de PHB, assim como a miscibilidade parcial do PLA com o PHB de baixa massa molar.

  6. Computación de altas prestaciones: problemáticas y aplicaciones

    OpenAIRE

    Balladini, Javier; Morán, Marina; Rozas, Claudia; Frati, Fernando Emmanuel; De Giusti, Armando Eduardo; Suppi, Remo; Rexachs del Rosario, Dolores; Luque, Emilio

    2016-01-01

    Nuestra investigación está centrada en dos lí- neas. Por un lado, el estudio del consumo energé- tico de los sistemas de Cómputo de Altas Prestaciones (HPC, de High Performance Computing) cuya alta demanda energética tiene serias consecuencias nancieras, medioambientales, y en muchos casos también sociales. El aumento de la e ciencia energética de los sistemas de HPC no solo proviene de las nuevas arquitecturas hardware, también está involucrado el software, quien debe gestionar y con gurar ...

  7. ALTAS CAPACIDADES: COMPARATIVA ENTRE EL MODELO ESPAÑOL Y BRITÁNICO

    OpenAIRE

    Rodríguez-Vázquez, María

    2012-01-01

    El presente trabajo de investigación exploratoria reflexiona sobre el concepto de alumno con altas capacidades y propone una comparación legislativa entre el modelo de atención a los alumnos con altas capacidades británico y español y cómo ese modelo afecta al sistema educativo general, ya que aunque tienen puntos en común entre ambos países, pero se trata dos formas de enfocar completamente distintas. Además también pretende recoger información sobre iniciativas y proyectos que reflejen l...

  8. Altas capacidades: Proyecto educativo para el aula de Educación Primaria

    OpenAIRE

    López-Presedo, Iria Flavia

    2015-01-01

    El presente TFG tiene como principal finalidad dar una respuesta educativa, eminentemente práctica, al alumnado de altas capacidades dentro del grupo-clase. En primer lugar, se han revisado las teorías de varios autores sobre las altas capacidades, los métodos de detección e intervención con este tipo de alumnado y, finalmente, se ha elaborado un proyecto en forma de programa de enriquecimiento curricular. Este proyecto se inscribe dentro de la Teoría de las inteligencias múltiples de Gard...

  9. Altas capacidades intelectuales : investigación y propuesta desde las inteligencias múltiples

    OpenAIRE

    Pulido Vinuesa, Salomé

    2015-01-01

    El presente trabajo trata sobre las altas capacidades, investigando sobre ello acerca de su historia y evolución, los diversos tipos existentes, sus características, su identificación, su evaluación, sus metodologías, entre otros. Además, se ha realizado un resumen de cómo es tratada esta necesidad educativa por las leyes, antiguas y en vigor. De igual modo, se trata la educación inclusiva, ya que es un tema que afecta a alumnos/as con altas capacidades. El programa de intervención en rel...

  10. Procesos de fractura dinámica en hormigón de alta resistencia

    OpenAIRE

    Tarifa Crespo, Manuel Agustín

    2012-01-01

    El objetivo de la presente tesis se centra en el estudio de los procesos de fractura en régimen dinámico, de un material tan importante en grandes obras de ingeniería civil como es el hormigón de alta resistencia. Muchas son las investigaciones realizadas hasta la fecha sobre el comportamiento dinámico en fractura del hormigón convencional, pero muy pocas las llevadas a cabo sobre el hormigón de alta resistencia. En esta tesis se desarrolla un programa experimental dirigido a estudiar l...

  11. 50 años de alta velocidad en Japón

    OpenAIRE

    Pigem Cameselle, Ramiro

    2008-01-01

    Al inaugurar los 515 kilómetros de línea de alta velocidad entre Tokio y Osaka en octubre de 1964, Japón alcanzó un logro todavía mayor que el de impulsar su propia economía. Abrió una era del transporte completamente nueva con un innovador sistema ferroviario. Con ello prestó un innegable servicio al mundo ferroviario, desencadenando un auge global de la alta velocidad e inyectando aire fresco a una industriar que estaba en claro declive. Casi 50 años más tarde, los 210 km/h inic...

  12. Respostas lactacidêmicas de ratos ao treinamento intermitente de alta intensidade

    OpenAIRE

    Ana Carolina Panveloski-Costa; Marcelo Papoti; Rafael Junges Moreira; Patricia Monteiro Seraphim

    2012-01-01

    Durante contrações musculares de alta intensidade intervaladas por curtos períodos de tempo há importante participação do metabolismo glicolítico e, consequentemente, aumento das concentrações de lactato sanguíneo. O objetivo do estudo foi avaliar as respostas lactacidêmicas agudas e crônicas de ratos Wistar submetidos a um treinamento intermitente de alta intensidade (salto tipo jump squat) de três sessões semanais, a cada 24h, três séries de 12 repetições com intervalos de 60s entre cada um...

  13. Neurociências, altas habilidades e implicações no currículo

    OpenAIRE

    Amauri Betini Bartoszeck

    2014-01-01

    http://dx.doi.org/10.5902/1984686X14284O presente estudo inicialmente define e descreve as sub-disciplinas que compõem as neurociências com potenciais aplicações educacionais para crianças e adultos  identificados com altas habilidades. Objetiva-se com uma breve introdução morfofuncional ao sistema nervoso que serve de pano de fundo para auxiliar o entendimento da ponte teórico-experimental da relação de neurociências e altas habilidades. São salientados aspectos da base evolucionista e bioló...

  14. Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype.

    Science.gov (United States)

    Krause, Amanda; Mitchell, Claire; Essop, Fahmida; Tager, Susan; Temlett, James; Stevanin, Giovanni; Ross, Christopher; Rudnicki, Dobrila; Margolis, Russell

    2015-10-01

    Huntington disease (HD) is a progressive autosomal dominant neurodegenerative disorder, characterized by abnormal movements, cognitive decline, and psychiatric symptoms, caused by a CAG repeat expansion in the huntingtin (HTT) gene on chromosome 4p. A CAG/CTG repeat expansion in the junctophilin-3 (JPH3) gene on chromosome 16q24.2 causes a Huntington disease-like phenotype (HDL2). All patients to date with HDL2 have some African ancestry. The present study aimed to characterize the genetic basis of the Huntington disease phenotype in South Africans and to investigate the possible origin of the JPH3 mutation. In a sample of unrelated South African individuals referred for diagnostic HD testing, 62% (106/171) of white patients compared to only 36% (47/130) of black patients had an expansion in HTT. However, 15% (20/130) of black South African patients and no white patients (0/171) had an expansion in JPH3, confirming the diagnosis of Huntington disease like 2 (HDL2). Individuals with HDL2 share many clinical features with individuals with HD and are clinically indistinguishable in many cases, although the average age of onset and diagnosis in HDL2 is 5 years later than HD and individual clinical features may be more prominent. HDL2 mutations contribute significantly to the HD phenotype in South Africans with African ancestry. JPH3 haplotype studies in 31 families, mainly from South Africa and North America, provide evidence for a founder mutation and support a common African origin for all HDL2 patients. Molecular testing in individuals with an HD phenotype and African ancestry should include testing routinely for JPH3 mutations. PMID:26079385

  15. Self-rated health showed a consistent association with serum HDL-cholesterol in the cross-sectional Oslo Health Study

    Directory of Open Access Journals (Sweden)

    Sissel E. Tomten, Arne T. Høstmark

    2007-01-01

    Full Text Available Objective: To examine the association between serum HDL-cholesterol concentration (HDL-C and self rated health (SRH in several age groups of men and women. Study design and setting: The study had a cross-sectional design and included 18,770 men and women of the Oslo Health Study aged 30; 40 and 45; 69-60; 75-76 years. Results: In both sexes and all age groups, SRH (3 categories: poor, good, very good was positively correlated with HDL-C. Logistic regression analysis on dichotomized values of SRH (i.e. poor vs. good health in each age group of men and women showed that increasing HDL-C values were associated with increasing odds for reporting good health; the odds ratio (OR was highest in young men, and was generally lower in women than in men. Odds ratios in the 4 age groups of men were 4.94 (2.63-9.29, 2.25 (1.63-3.09, 2.12 (1.58-2.86, 1.87 (1.37-2.54; and in women: 3.58 (2.46-5.21, 2.81 (2.23-3.53, 2.28 (1.84-2.82, 1.61 (1.31-1.99. In the whole material, 1 mmol/L increase in HDL-C increased the odds for reporting good health by 2.27 (2.06-2.50; p<0.001, when adjusting for sex, age group, time since food intake and use of cholesterol lowering drugs. Chronic diseases, pain, psychological distress, smoking, alcohol, length of education, and dietary items did not have any major influence on the pattern of the HDL-C vs. SRH association. Conclusion: There was a consistent positive association between HDL-C and SRH, in both men and women in four different age groups, with the strongest association in young people.

  16. The TG/HDL Cholesterol Ratio Predicts All Cause Mortality in Women With Suspected Myocardial Ischemia A Report from the Women’s Ischemia Syndrome Evaluation (WISE)

    Science.gov (United States)

    Bittner, Vera; Johnson, B. Delia; Zineh, Issam; Rogers, William J.; Vido, Diane; Marroquin, Oscar C.; Bairey-Merz, C. Noel; Sopko, George

    2009-01-01

    High triglycerides (TG) and low high density lipoprotein cholesterol (HDL-C) are important cardiovascular risk factors in women. The prognostic utility of the TG/HDL-C ratio, a marker for insulin resistance and small dense low density lipoprotein particles, is unknown among high risk women. Methods We studied 544 women without prior myocardial infarction or coronary revascularization, referred for clinically indicated coronary angiography and enrolled in the Women’s Ischemia Syndrome Evaluation (WISE). Fasting lipid profiles and detailed demographic and clinical data were obtained at baseline. Multi-variate Cox-proportional hazards models for all cause mortality and cardiovascular events (death, myocardial infarction, heart failure, stroke) over a median follow-up of 6 years were constructed using log TG/HDL-C ratio as a predictor variable and accounting for traditional cardiovascular risk factors. Results Mean age was 57±11 years, 84% were white, 55% hypertensive, 20% diabetic, 50% current or prior smokers. TG/HDL-C ranged from 0.3 to 18.4 (median 2.2, first quartile 0.35 to <1.4, fourth quartile 3.66–18.4). Deaths (n=33) and CV events (n=83) increased across TG/HDL-C quartiles (both p<0.05 for trend). TG/HDL-C was a strong independent predictor of mortality in models adjusted for age, race, smoking, hypertension, diabetes, and angiographic coronary disease severity (HR 1.95, 95% CI 1.05, 3.64, p=0.04). For cardiovascular events, the multivariate HR was 1.54 (95% CI 1.05, 2.22, p=0.03) when adjusted for demographic and clinical variables, but became non-significant when angiographic results were included. Conclusion Among women with suspected ischemia, the TG/HDL-C ratio is a powerful independent predictor of all cause mortality and cardiovascular events. PMID:19249427

  17. Densidad y preferencia de hábitat del perezoso de dos dedos Choloepus hoffmanni en un bosque andino (Bojacá, Cundinamarca, Colombia

    Directory of Open Access Journals (Sweden)

    Polanco Rocío

    2004-12-01

    Full Text Available Se estimó la densidad de perezosos de dos dedos Choloepus hoffmanni en un bosque andino fragmentado, a partir del conteo de restos fecales en parcelas fijas. Se caracterizó la vegetación del área y los árboles usados por los perezosos, con el fin de evaluar la preferencia de hábitat a dos escalas diferentes, así como la relación de las características del hábitat sobre la densidad de perezosos y la frecuencia de uso de los árboles. La densidad de perezosos en el área de estudio fue de 1,5 individuos/ha y varió entre tres fragmentos de bosque evaluados, diferentes en composición y estructura. Las densidades estimadas en las tres áreas de bosque resultaron
    en amplios intervalos de confianza, lo que es común a técnicas de conteo de heces. Aunque ninguna de las variables evaluadas de la vegetación explicó las diferencias de densidad entre bosques, el mayor desarrollo de la vegetación arbórea de una de las áreas de bosque dominado por Quercus humboldtii, y la evasión de la especie Miconia tonduzzi por los perezosos explicaría las diferencias en la densidad de perezosos, así como la evasión de una de las áreas de bosque. C. hoffmanni utiliza una gran variedad de especies arbóreas, pero con mayor frecuencia las especies Q. humboldtii y Brunellia tonduzii. Los árboles donde se realizaron avistamientos difieren de los árboles cercanos a restos fecales de Choloepus hoffmanni en cuanto a altura, DAP y porcentaje de la copa expuesta al sol. Ninguna de las variables evaluadas fue relevante para el uso
    de algunas especies de árboles con mayor frecuencia.

  18. Avaliação dos efeitos da adição de sal e da densidade no transporte de tambaqui

    Directory of Open Access Journals (Sweden)

    Gomes Levy de Carvalho

    2003-01-01

    Full Text Available Os objetivos deste trabalho foram testar a eficiência do sal como redutor de estresse e verificar a melhor densidade de transporte de juvenis de tambaqui (Colossoma macropomun em caixas de plástico adaptadas. No primeiro experimento foram testadas diferentes concentrações de sal de cozinha (NaCl na água; no segundo, o transporte foi realizado por três horas em caixas de plástico de 200 L estocadas com diferentes densidades de peixe, com 8 g de sal/L de água. O cortisol plasmático dos peixes sofreu aumento significativo após o transporte no tratamento sem sal e com 2 g de sal/L de água, retornando para níveis normais após 96 horas. A glicose plasmática dos peixes sofreu aumento após o transporte em todas as concentrações de sal testadas, com exceção da com 8 g/L de água, retornando para níveis normais em 24 horas. Nos peixes transportados no segundo experimento, com 8 g de sal/L de água, não foi verificada mudança significativa no cortisol plasmático, mas a glicose aumentou significativamente em todas as densidades após o transporte, retornando para níveis normais em 24 horas. Houve mortalidade de 11% em uma das repetições da densidade de 200 kg/m³ de água. Para o transporte com 8 g de sal/L de água, a densidade máxima deve ser de 150 kg/m³ de água. Nesta densidade os parâmetros físico-químicos de qualidade de água se mantêm com características adequadas, as respostas ao estresse são mínimas e não há mortalidade.

  19. Levels of high-density lipoprotein cholesterol (HDL-C among children with steady-state sickle cell disease

    Directory of Open Access Journals (Sweden)

    Seixas Magda O

    2010-08-01

    Full Text Available Abstract Background The search for sickle cell disease (SCD prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C in steady-state children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, anti-aggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. Methods We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records. Results Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P Conclusions We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesis.

  20. Diseño de decodificadores de altas prestaciones para código LDPC

    OpenAIRE

    Angarita Preciado, Fabian Enrique

    2013-01-01

    En esta tesis se han investigado los algoritmos de decodificación para códigos de comprobación de paridad de baja densidad (LDPC) y las arquitecturas para la implementación hardware de éstos. El trabajo realizado se centra en los algoritmos del tipo de intercambio de mensajes para códigos estructurados los cuales se incluyen en varios estándares de comunicaciones. Inicialmente se han evaluado las prestaciones de los algoritmos existentes Sum-product, Min-Sum y las principales variantes de...

  1. 77 FR 35669 - AltaGas Renewable Energy Colorado LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2012-06-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AltaGas Renewable Energy Colorado LLC; Supplemental Notice That Initial... notice in the above-referenced proceeding of AltaGas Renewable Energy Colorado LLC application for...

  2. 77 FR 23712 - Alta Wind VII, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Science.gov (United States)

    2012-04-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Alta Wind VII, LLC; Supplemental Notice That Initial Market-Based Rate...-referenced proceeding of Alta Wind VII, LLC's application for market-based rate authority, with...

  3. Relación entre paraoxonasa, otros componentes de HDL y estado inflamatorio en hemodiálisis

    Directory of Open Access Journals (Sweden)

    Ana Inés González

    2010-12-01

    Full Text Available La enfermedad renal crónica (ERC se asocia estrechamente con un estado pro-inflamatorio, aumento de lipoproteínas ricas en triglicéridos y disminución de HDL. La HDL contiene enzimas antioxidantes asociadas como la paraoxonasa (PON, cuya actividad en ERC se encuentra disminuida. Nuestro objetivo fue evaluar la relación entre la actividad de PON, apoA1, colesterol(col-HDL y Proteína C reactiva-altamente sensible (PCR-as como marcador de inflamación en pacientes en hemodiálisis. Se estudiaron n = 42 pacientes; edad, mediana (rango = 50 (25-67 años; sexo M/F = 22/20; antigüedad de hemodiálisis = 4.4 ± 0.5 años; índice de masa corporal (IMC = 23 ± 0.5 kg/m². Se obtuvo una muestra de sangre después de 12 h de ayuno y se determinaron los parámetros clásicos del perfil lipídico, se midieron los valores de apoproteínas A1 y B, PON a través de su actividad arilesterasa y PCR-as, la cual permitió dividir a los pacientes con PCR-as ≤ 1 (bajo riesgo, rango: 0.1 a 1.0 mg/l y > 1 mg/l (moderado y alto riesgo, 1.1 a 10.7 mg/l. Los niveles de triglicéridos, col-LDL y apoB no fueron diferentes entre los grupos. Los pacientes con PCR-as > 1 presentaron menor col-HDL (40 ± 2 mg/dl y apoA1 (118 ± 4 mg/dl que los pacientes con PCR-as ≤ 1 (50 ± 4 y 133 ± 5, respectivamente; p 1: 90.5 ± 24.0 μmol/ml.min que en PCR-as ≤ 1: 105.2 ± 18.0. Consecuentemente, se obtuvieron correlaciones inversas entre apoA1 y PCR-as, r = -0.381 p = 0.013 y entre PON y PCR-as, r = -0.32, p = 0.042. Además, el aumento de PCR-as correlacionó positivamente con el IMC, r = 0.318, p = 0.042. La disminución de col-HDL, apoA1 y PON en los individuos con mayor estado inflamatorio explicaría, en parte, el aumento de riesgo cardiovascular de estos pacientes, dado los efectos antiinflamatorios de la apoA1 y antioxidantes de la PON.

  4. Sistema de cómputo reconfigurable de alta performance (proyecto HPRC)

    OpenAIRE

    Kunysz, Eduardo; Rapallini, José Antonio; Osio, Jorge R.

    2015-01-01

    El objetivo de este trabajo es el estudio de las nuevas tendencias en cómputo paralelo con la finalidad de mejorar el rendimiento de cálculo. Cómo una alternativa interesante para optimizar la relación costo-prestaciones, se exploran tecnologías de computadoras de alta performance reconfigurable (HPCR).

  5. Grounding the past : the praxis of participatory archaeology in the Mixteca Alta, Oaxaca, Mexico

    NARCIS (Netherlands)

    Geurds, Alexander

    2007-01-01

    "Grounding the Past" addresses archaeological field praxis and its role in the political present of Santiago Tilantongo and Santiago Apoala, two communities in the Mixteca Alta region of Oaxaca, Mexico. Efforts to involve local stakeholder communities in archaeology have become an important issue wo

  6. La evaluación psicopedagógica del alumnado con altas capacidades

    OpenAIRE

    Grau Rubio, Claudia

    2012-01-01

    Se describen los instrumentos de evaluación psicopedagógica aplicables al alumnado con altas capacidades. Instrumentos referidos al alumno, al contexto escolar, a las variables socio-familiares y la determinación de las necesidades educativas especiales.

  7. Respostas lactacidêmicas de ratos ao treinamento intermitente de alta intensidade

    Directory of Open Access Journals (Sweden)

    Ana Carolina Panveloski-Costa

    2012-04-01

    Full Text Available Durante contrações musculares de alta intensidade intervaladas por curtos períodos de tempo há importante participação do metabolismo glicolítico e, consequentemente, aumento das concentrações de lactato sanguíneo. O objetivo do estudo foi avaliar as respostas lactacidêmicas agudas e crônicas de ratos Wistar submetidos a um treinamento intermitente de alta intensidade (salto tipo jump squat de três sessões semanais, a cada 24h, três séries de 12 repetições com intervalos de 60s entre cada uma. Houve aumento das concentrações de lactato sanguíneo durante a sessão aguda do treinamento (lactacidemia basal vs. lactacidemia após último esforço, P < 0,001. Contrariamente, após seis semanas de treinamento, ocorreu redução de 49% na resposta lactacidêmica ao exercício em relação à primeira sessão, P = 0,0002. O exercício intermitente de alta intensidade intervalado favorece a participação do sistema glicolítico; no entanto, o treinamento intermitente de alta intensidade promove redução das respostas lactacidêmicas, sugerindo melhora da capacidade de ressíntese de fosfocreatina e da biogênese mitocondrial.

  8. Effects of extended-release niacin/laropiprant, simvastatin, and the combination on correlations between apolipoprotein B, LDL cholesterol, and non-HDL cholesterol in patients with dyslipidemia

    Directory of Open Access Journals (Sweden)

    Farnier M

    2014-05-01

    Full Text Available Michel Farnier,1 Erluo Chen,2 Amy O Johnson-Levonas,2 Christine McCrary Sisk,2 Yale B Mitchel21Point Médical, Dijon, France; 2Merck and Co, Inc., Whitehouse Station, NJ, USABackground: Statins modify correlations between apolipoprotein B (apoB and low-density lipoprotein cholesterol (LDL-C and apoB and non-high-density lipoprotein cholesterol (non-HDL-C; however, it is not known whether niacin-based therapies have similar effects.Objective: To evaluate the effects of extended-release niacin (ERN/laropiprant (LRPT, simvastatin (SIMVA, and ERN/LRPT + SIMVA (pooled ERN/LRPT + SIMVA on apoB:LDL-C and apoB:non-HDL-C correlations in dyslipidemic patients.Methods: This post-hoc analysis of a 12-week study evaluated the apoB:LDL-C and apoB:non-HDL-C correlations in dyslipidemic patients randomized equally to double-blind ERN/LRPT 1 g/20 mg, SIMVA 10, 20, or 40 mg, or ERN/LRPT 1 g/20 mg + SIMVA (10, 20, or 40 mg once daily for 4 weeks. At week 5, doses were doubled in all groups except SIMVA 40 mg (unchanged and ERN/LRPT 1 g/20 mg + SIMVA 40 mg (switched to ERN/LRPT 2 g/40 mg + SIMVA 40 mg. Simple linear regression analyses were used to calculate LDL-C and non-HDL-C levels corresponding to known apoB baseline values (ie, in untreated patients and following treatment.Results: The apoB:LDL-C and apoB:non-HDL-C correlations were higher and the predicted LDL-C and non-HDL-C levels for a known apoB value were considerably lower following treatment with ERN/LRPT, SIMVA and ERN/LRPT + SIMVA compared with untreated patients at baseline.Conclusion: Greater dissociation of apoB, LDL-C, and non-HDL-C targets occur following treatment with ERN/LRPT, SIMVA, and ERN/LRPT + SIMVA in patients with dyslipidemia. The achievement of more aggressive LDL-C and non-HDL-C goals in patients receiving lipid-modifying therapy may further reduce coronary risk by normalizing apoB-containing atherogenic lipoproteins.Keywords: apoB, LDL-C, non-HDL-C

  9. Pneumonia lipoídica em adultos: aspectos na tomografia computadorizada de alta resolução Lipoid pneumonia in adults: findings on high-resolution computed tomography

    Directory of Open Access Journals (Sweden)

    Edson Marchiori

    2007-10-01

    Full Text Available OBJETIVO: Apresentar os aspectos na tomografia computadorizada de alta resolução do tórax da pneumonia lipoídica exógena por aspiração de óleo mineral, em pacientes adultos MATERIAIS E MÉTODOS: Foram estudados oito pacientes adultos - quatro mulheres e quatro homens - com média de idade de 69,4 anos, todos usuários de óleo mineral para tratamento de constipação intestinal. Os exames foram avaliados por dois radiologistas, de forma independente RESULTADOS: Os achados tomográficos mais comuns foram as consolidações com áreas de densidade de gordura de permeio, e o padrão de pavimentação em mosaico. As lesões foram bilaterais em seis pacientes, e unilaterais em dois CONCLUSÃO: O encontro de consolidações pulmonares com áreas de densidade de gordura de permeio, associado à história clínica do uso de óleo mineral, é diagnóstico de pneumonia lipoídica exógena.OBJECTIVE: The present study was aimed at describing the findings on high-resolution computed tomography in patients with exogenous lipoid pneumonia secondary to mineral oil aspiration MATERIALS AND METHODS: Eight adult patients - four men and four women - with mean age of 69.4 years were studied. All of the patients were users of mineral oil for treating intestinal constipation. High-resolution computed tomography studies of these patients were blindly evaluated by two radiologists. RESULTS: Air-space consolidation with areas of fat density and crazy paving pattern were the most frequent findings. The lesions were bilateral in six cases and unilateral in two CONCLUSION: Air-space consolidation with areas of fat density, associated with a clinical history of mineral oil ingestion virtually indicates a diagnosis of exogenous lipoid pneumonia.

  10. INFLUENCIA DE LA ALTA TEMPERATURA EN LOS TEJIDOS RADICULARES DE TOMATE (Lycopersicon esculentum Mill.

    Directory of Open Access Journals (Sweden)

    Ofelia Sam

    2006-01-01

    Full Text Available Los cambios cualitativos en los tejidos radiculares, como consecuencia de la alta temperatura empleada en este trabajo (38oC durante 1.5 horas, fueron estudiados en plántulas de dos variedades de tomate (Lycopersicon esculentum Mill., con diferentes grados de tolerancia a altas temperaturas. A los siete días de puestas a germinar las semillas de arroz, se aplicó el tratamiento de alta temperatura a las radículas de cada variedad, que fueron puestas en recipientes con agua, por separado, y colocadas en la estufa durante 1.5 h a 380C y el tratamiento control consistió en dejar al otro grupo de radículas en las condiciones del laboratorio durante la aplicación de la alta temperatura; a continuación se tomaron las muestras de radículas, que fueron procesadas para microscopía de luz, incluidas en resina epon y se realizaron cortes de 2 ¿m de grosor, los que fueron teñidos con azul de toluidina, observados y fotografiados en un microscopio con cámara digital acoplada. En las secciones longitudinales de las radículas, se pudo apreciar que la alta temperatura provocó aumento en el tamaño de las vacuolas y dilatación de las paredes celulares, entre otras alteraciones; estos cambios se hicieron más evidentes en la variedad considerada como tolerante a ese estrés.

  11. Análise de agrupamento de diferentes densidades de marcadores no mapeamento genético por varredura genômica

    OpenAIRE

    Marcelo Jangarelli; Ricardo Frederico Euclydes; Cosme Damião Cruz; Paulo Roberto Cecon; Antonio Policarpo Souza Carneiro

    2010-01-01

    A simulação tem contribuído para o avanço da genômica nas diversas áreas do melhoramento genético. Foram simulados mapeamentos genéticos utilizando diferentes densidades de marcadores para estimar os valores fenotípicos na seleção assistida por marcadores (SAM), em características quantitativas com valores de herdabilidade de 0,10; 0,40; e 0,70. Procedeu-se a análise de agrupamento com os desempenhos fenotípicos, cuja finalidade foi obter estruturas de classificação entre as densidades visand...

  12. Heliconia acuminata reproductive success is independent of local floral density O sucesso reprodutivo de Heliconia acuminata é independente da densidade floral local

    Directory of Open Access Journals (Sweden)

    Emilio M. Bruna

    2004-09-01

    Full Text Available Reproductive plants in tropical forests are patchily distributed, with some in large aggregations of reproductive consepecifics while others are relatively isolated. This variation in floral density is hypothesized to have a major effect on plant reproductive success, since individuals in higher density neighborhoods can attract more or higher quality pollinators. We experimentally tested this hypothesis with populations of the understory herb Heliconia acuminata in central Amazonia. We created replicated plots in which reproductive plant density spanned the range of naturally occurring floral neighborhood size, then measured three surrogates of plant fitness in focal plants in each array. There was no significant difference between any of the three floral neighborhood treatments in total seed production, fruit set, or the number of seeds produced per fruit. Pollinator visitation rates to plants in all treatments were extremely low, with many plants not visited at all during the observation period. This could be because H. acuminata's hummingbird pollinators are unable to find the widely scattered reproductive plants, however this hypothesis appears unlikely. Instead, natural flowering plant densities may simply be below the threshold value at which neighborhood effects become important, even in "high-density" aggregations. Nutrient limitation, selective fruit abortion, and reproduction via male rather than female function may also be playing a role. We argue the absence of neighborhood effects may be a general phenomenon in central Amazonian forests, though additional experiments with other plant-pollinator systems are needed to determine the extent to which this hypothesis is supported.Plantas reprodutivas em florestas tropicas são distribuidas em manchas, com algumas em grandes agregações coespecíficas e outras relativamente isoladas. A hipótese é que esta variação na densidade de flores em um local tem um grande efeito no sucesso

  13. Efecto de la densidad de siembra y la adición de ácido ascórbico en el cultivo de Osteoglossum bicirrhosum

    OpenAIRE

    Carolina Cuaical T.; Evelyn Vallejo V.; Hugo Franco R.; Wilmer Sanguino O.

    2015-01-01

    RESUMENObjetivo. Evaluar el efecto de la densidad de siembra y la adición de ácido ascórbico en la alimentación de alevinos de O. bicirrhosum, cultivados en jaulas. Materiales y métodos. Se incluyeron 396 alevinos y se distribuyeron en nueve tratamientos, resultado de la combinación de los niveles del factor densidad de siembra: 1pez/5 L; 1pez/10 L y 1pez/15 L y los niveles de ácido ascórbico: 0; 500 y 1000 mg/kg. Los datos obtenidos se evaluaron mediante el análisis de varianza del diseño fa...

  14. Rendimiento de maíz forrajero en respuesta a fertilización nitrogenada y densidad de población

    OpenAIRE

    José Antonio Cueto Wong; David Guadalupe Reta Sánchez; José Luis Barrientos Ríos; Guillermo González Cervantes; Enrique Salazar Sosa

    2006-01-01

    En este estudio se determinó el efecto de la densidad de población y dosis de fertilización nitrogenada sobre el rendimiento y eficiencia de uso de nitrógeno en maíz (Zea mays L.) forrajero durante el ciclo de verano en la Comarca Lagunera, México, mediante dos experimentos, uno en 1998 y otro en 1999. Se estudiaron tres dosis de fertilización nitrogenada (125, 250 y 375 kg ha-1) y cinco densidades de población (9.0, 12.0, 15.0, 18.0 y 21.0 plantas/m2 en 1998; y 8.5, 11.0, 13.5, 16.0 y 18.5 p...

  15. DENSIDAD DE POBLACIÓN Y FERTILIZACIÓN NITROGENADA EN LA PRODUCCIÓN DE SEMILLA HÍBRIDA DE MAÍZ

    OpenAIRE

    Francisco Cervantes-Ortíz; Jorge Covarrubias-Prieto; José Antonio Rangel-Lucio; Arturo Daniel Terrón-Ibarra; Mariano Mendoza-Elos; Ricardo Ernesto Preciado-Ortiz

    2013-01-01

    El presente estudio tuvo como objetivo determinar el efecto de la densidad de población y la fertilización nitrogenada en el rendimiento y calidad de semilla híbrida de maíz. El experimento se realizó en el Instituto de Nacional de Investigaciones Forestales, Agrícolas y Pecuarias-Campo Experimental Bajío (INIFAP-CEBAJ), en el ciclo P-V 2009. En la cruza CML 142 x CML 176, progenitor femenino del híbrido H-374C, se evaluaron tres densidades de población (60, 75 y 90 mil plantas/ha) y tres niv...

  16. Aplicación de relaciones de densidad-diámetro y de área potencial aprovechable en bosques de Nothofagus Dombeyi (mirb.) Oerst, como herramientas de planificación silvícola .

    OpenAIRE

    Cruz Johnson, Pablo Christian

    2013-01-01

    Uno de los objetivos de esta tesis de doctorado fue analizar la aplicación de relaciones de densidad ¿ diámetro en bosques de Nothofagus dombeyi (Mirb.) oerst, para la localidad del Río Mirta en la XI Región de Chile, como herramientas de planificación silvícola. El método de análisis consistió en la generación de una muestra de densidad¿diámetro a partir de la que se determinó el índice de densidad máximo (IDmax) a partir del cual se estimaron las máximas densidades que la especie podría alc...

  17. Variação da densidade anofélica com o uso de mosquiteiros impregnados com deltametrina em uma área endêmica de malária na Amazônia Brasileira Variation of anopheles density with deltamethrin-impregnated mosquito nets in an endemic malaria area of the Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    João Barberino Santos

    1999-04-01

    Full Text Available Em 1992, foi realizado um ensaio de campo com mosquiteiros impregnados com deltametrina, em uma área endêmica de malária no Município de Costa Marques, Rondônia. No período de baixa transmissão, os mosquiteiros impregnados (MI diminuíram a densidade vetorial no intradomicílio, de modo semelhante, porém, aos mosquiteiros não impregnados (NI na maioria das avaliações-controle. Por outro lado, na época de alta transmissão, os MI provocaram diminuição significante da média horária de anofelinos capturados, ao passo que, nas casas com NI, verificou-se aumento do número de mosquitos capturados. No peridomicílio, em geral, não houve diferença do número de anofelinos capturados entre MI e NI. No grupo MI, a espécie mais capturada foi o An. darlingi (63,2%, mais freqüente no peridomicílio, seguida pelo An. deaneorum (35,3%, mais freqüente no intradomicílio. Os MI diminuíram a densidade vetorial no intradomicílio pelo efeito excito-repelente, sem diminuí-la, contudo, no peridomicílio.In 1992 a survey on the use of deltamethrin-impregnated mosquito nets was conducted in the municipality of Costa Marques, Rondonia. In the intradomicile, impregnated nets decreased the vector density at rates similar to those for non-impregnated nets during low-transmission periods; during high anopheline density periods, they led to a significant reduction in vector density, while in the non-impregnated net group there was an increase in the number of anophelines captured. There was no change in vector density in the peridomicile. In the impregnated net group, the most frequently captured species was Anopheles darlingi (63.2%, found mostly in the peridomicile, while Anopheles deaneorum (35.3% was most frequent indoors. The impregnated mosquito nets' excitatory-repellent effect decreased the intradomiciliary vector density but did not alter density in the peridomicile.

  18. Influência da densidade de estocagem no cultivo de juvenis de robalo-flecha mantidos em laboratório

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    Souza-Filho José Jerônimo de

    2003-01-01

    Full Text Available O objetivo deste trabalho foi analisar a influência da densidade de estocagem no crescimento, conversão alimentar e sobrevivência de juvenis de robalo-flecha (Centropomus undecimalis. Os peixes foram coletados em ambiente natural e treinados a aceitar dietas artificiais. Os indivíduos, com comprimento total de 13±0,4 cm e peso de 23±0,3 g foram estocados em tanques circulares de fibra de vidro de 5 m³, com água do mar e aeração contínua, nas densidades de 3, 6 e 9 peixes/m³, por 180 dias. Os valores de amônia total (0 a 0,5 mg/L, temperatura da água (23,3 a 30,6ºC, salinidade (17 a 34 g/L, pH (7,8 a 8,4 e oxigênio dissolvido (4,8 a 6,9 mg/L apresentaram padrão similar entre os tratamentos. A conversão alimentar (1,88, 2,06 e 2,31 e a sobrevivência (100%, 98,9% e 96,3% foram significativamente melhores nos tratamentos com 3 e 6 peixes/m³. As médias finais de peso (110, 87 e 80 g e comprimento total (20, 18,5 e 18 cm apresentaram diferença significativa. A maior taxa de crescimento foi observada com 3 peixes/m³; entre as demais não houve diferença. Entretanto, a biomassa final (332, 511 e 703 g/m³ foi diretamente proporcional à densidade. A baixa densidade favorece o cultivo do robalo em relação ao crescimento, sobrevivência e conversão alimentar.

  19. Densidad y distribución sobre CSMA/CA en redes IEEE 802.11g en modo AD HOC

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    José Domínguez

    2010-09-01

    Full Text Available El propósito  principal de la presente investigación, fue determinar la influencia de la densidad y distribución de hosts sobre el control de acceso al medio en redes IEEE 802.11g, tomando como variables fundamentales la densidad y distribución de los mismos y el protocolo CSMA/CA para el acceso al medio de transmisión.  La investigación fue de tipo explicativa, con un diseño  experimental puro. La misma se basó en los postulados teóricos de Bates (2003, Comer (2000, León García (2001, Stallings (2005, Tanenbaum (2003, entre otros. El procedimiento a utilizar fue diseñado por el investigador y consistió de cuatro (04 fases: Enfoque teórico, experimentación, Recolección y análisis de los datos y elaboración de conclusiones y recomendaciones.  La cantidad de hosts a utilizar en la red se ubicó en seis 06 equipos portátiles con especificaciones técnica similares. Para la recolección de la información se diseño un (1 instrumento, tipo formato de datos, en el cual se registraron diez (10 parámetros diferentes para evaluar el desempeño de la red en diversos escenarios. Seguidamente se tabularon los datos en cuadros, para proceder al análisis cuantitativo de los mismos. Se concluye que la densidad y distribución de los hosts en redes IEEE 802.11g afectan el acceso al medio de transmisión.Palabras clave: Densidad, distribución, red, ad hoc, control de acceso al medio.

  20. Participação do colmo principal e dos afilhos na produtividade do arroz irrigado, em função da densidade de semeadura

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    Eduardo do Valle Lima

    2010-01-01

    Full Text Available Entre as práticas culturais a serem consideradas na implantação da cultura do arroz destaca-se a densidade de semeadura, que deve estabelecer, em grande parte, a participação do colmo principal e dos afilhos nos componentes da produção, possibilitando a obtenção da máxima produtividade. O trabalho teve como objetivo avaliar a participação do colmo principal e dos afilhos na produtividade de grãos de arroz, cv. IAC 102, no sistema irrigado por inundação, em função da densidade de semeadura. O experimento foi desenvolvido sob túnel plástico, em Botucatu (SP, em caixas d'água de cimento amianto de 500 L, contendo Neossolo Flúvico Ta Eutrófico, com profundidade de 30 cm. O delineamento experimental foi o inteiramente casualizado, com quatro repetições. As densidades de semeadura foram: 100, 200, 300, 400, 500 e 600 sementes viáveis por m², em 4 linhas de 1 m por caixa, espaçadas com 20 cm. A elevação da densidade de semeadura diminui o afilhamento e proporciona a maior participação dos colmos principais, porém, não resultando em incremento de produtividade, devido à plasticidade das plantas de arroz, que proporciona o ajustamento dos componentes da produção.

  1. Estudio del comportamiento durante la sinterización de mezclas WC-Co finas, ultrafinas y nanocristalinas obtenidas por molienda de alta energía

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    Salvador, M. D.

    2008-10-01

    Full Text Available In this work the sintering behaviour of fine, ultrafine and nanocrystalline WC-12Co mixtures obtained by high energy milling, as well as commercial nanopowders, have been studied, in order to evaluate the effect of the particle size and the powder processing, in the densification, microstructural development and mechanical properties of the final product. The consolidation of the mixtures has been made by uniaxial pressing and sintering in vacuum, and by hot isostatic pressing. The sintered materials have been evaluated by measures of density, hardness and indentation fracture toughness, and microstructurally characterized by optical microscopy and scanning and transmission electronic microscopy (SEM and TEM. The results show the improvements in resistant behaviour of the materials obtained from nanocrystalline powders, in spite of the grain growth experienced during the sintering. The best results were obtained for the milling nanocrystalline material, which presents values of hardness higher than 1800 HV.

    En este trabajo se ha estudiado el comportamiento, durante la sinterización, de mezclas WC-12Co finas, ultrafinas y nanométricas obtenidas por molienda de alta energía y de material nanométrico comercial, a fin de evaluar el efecto del tamaño de partícula y del proceso de obtención del polvo en la densificación, desarrollo microestructural y propiedades mecánicas del producto final. La consolidación de las mezclas se ha realizado mediante compactación uniaxial y sinterización en vacío y por compactación isostática en caliente. Los materiales sinterizados se han evaluado mediante medidas de densidad, dureza y tenacidad a fractura por indentación y se han caracterizado microestructuralmente mediante microscopía óptica y microscopía electrónica de barrido y de transmisión. Los resultados obtenidos ponen de manifiesto las mejoras en comportamiento resistente de los materiales obtenidos a partir polvos nanométricos, a

  2. EFECTOS DE LA DENSIDAD DE SIEMBRA Y FERTILIZACIÓN SOBRE LA BACTERIOSIS DEL PALMITO DE PEJIBAYE (Bactris gasipaes K.

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    Francisco Paulo Chaimsohn

    2008-01-01

    Full Text Available Se determinó el efecto de la densidad (3.333, 5.000 y 6.666 plantas/ha, el arreglo de siembra (rectangular y triangular y el tipo de fertilización (químico, orgánico y químico-orgánico sobre la incidencia y severidad de la enfermedad conocida como "bacteriosis del palmito", causada por la bacteria Pantoea stewartii (sin. Erwinia stewartii y el hongo Fusarium sp, en el periodo de julio de 2004 a agosto de 2005, en Guápiles, Costa Rica. El porcentaje de incidencia de la enfermedad varió de 14,1 a 80,8%. En las parcelas con el arreglo triangular hubo menor porcentaje de plantas enfermas. El porcentaje de incidencia de la bacteriosis fue mayor en las cepas de las parcelas fertilizadas con abono químico, seguido de aquellas fertilizadas con abono químico-orgánico y enmienda orgánica. La enfermedad se correlacionó de forma inversa a los contenidos de Ca, Mg, Zn, K y Mn del suelo, y al contenido foliar de Mn. Por otra parte, se correlacionó de forma directa con el contenido de Al del suelo, con los contenidos foliares de B y Cu, y con el porcentaje de interceptación de la radiación solar.

  3. DENSIDADES Y PROPIEDADES VOLUMÉTRICAS DE LA MEZCLA N,N-DIMETILFORMAMIDA (DMF + 1-BUTANOL A DIFERENTES TEMPERATURAS

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    MANUEL PÁEZ

    2013-01-01

    Full Text Available Se determinaron las densidades de la mezcla binaria de N,N-Dimetilformamida (DMF + 1-Butanol usando un densímetro de tubo vibrador DMA 5000, sobre todo el intervalo de fracciones molares en el intervalo de temperaturas de 283.15K a 313.15K y 1.011 bar. Se calcularon los volúmenes molares de exceso (V e m volúmenes molares parciales (Vi, volúmenes molares parciales a dilución infinita (V i ∞ , volúmenes molares parciales de exceso ( V i E del soluto y del solvente. Los volúmenes molares de exceso se correlacionaron usando la ecuación de Redlich-Kister. Adicionalmente, se calcularon los coeficientes viriales (bv de acuerdo a la teoría de McMillan-Mayer. Los valores obtenidos para estos parámetros fueron discutidos en términos de las interacciones presentes en solución.

  4. Cholesteryl Ester Transfer Protein (CETP polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk.

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    Audrey C Papp

    Full Text Available Polymorphisms in and around the Cholesteryl Ester Transfer Protein (CETP gene have been associated with HDL levels, risk for coronary artery disease (CAD, and response to therapy. The mechanism of action of these polymorphisms has yet to be defined. We used mRNA allelic expression and splice isoform measurements in human liver tissues to identify the genetic variants affecting CETP levels. Allelic CETP mRNA expression ratios in 56 human livers were strongly associated with several variants 2.5-7 kb upstream of the transcription start site (e.g., rs247616 p = 6.4 × 10(-5, allele frequency 33%. In addition, a common alternatively spliced CETP isoform lacking exon 9 (Δ9, has been shown to prevent CETP secretion in a dominant-negative manner. The Δ 9 expression ranged from 10 to 48% of total CETP mRNA in 94 livers. Increased formation of this isoform was exclusively associated with an exon 9 polymorphism rs5883-C>T (p = 6.8 × 10(-10 and intron 8 polymorphism rs9930761-T>C (5.6 × 10(-8 (in high linkage disequilibrium with allele frequencies 6-7%. rs9930761 changes a key splicing branch point nucleotide in intron 8, while rs5883 alters an exonic splicing enhancer sequence in exon 9.The effect of these polymorphisms was evaluated in two clinical studies. In the Whitehall II study of 4745 subjects, both rs247616 and rs5883T/rs9930761C were independently associated with increased HDL-C levels in males with similar effect size (rs247616 p = 9.6 × 10(-28 and rs5883 p = 8.6 × 10(-10, adjusted for rs247616. In an independent multiethnic US cohort of hypertensive subjects with CAD (INVEST-GENE, rs5883T/rs9930761C alone were significantly associated with increased incidence of MI, stroke, and all-cause mortality in males (rs5883: OR 2.36 (CI 1.29-4.30, p = 0.005, n = 866. These variants did not reach significance in females in either study. Similar to earlier results linking low CETP activity with poor outcomes in males, our results suggest genetic, sex

  5. Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk.

    Science.gov (United States)

    Papp, Audrey C; Pinsonneault, Julia K; Wang, Danxin; Newman, Leslie C; Gong, Yan; Johnson, Julie A; Pepine, Carl J; Kumari, Meena; Hingorani, Aroon D; Talmud, Philippa J; Shah, Sonia; Humphries, Steve E; Sadee, Wolfgang

    2012-01-01

    Polymorphisms in and around the Cholesteryl Ester Transfer Protein (CETP) gene have been associated with HDL levels, risk for coronary artery disease (CAD), and response to therapy. The mechanism of action of these polymorphisms has yet to be defined. We used mRNA allelic expression and splice isoform measurements in human liver tissues to identify the genetic variants affecting CETP levels. Allelic CETP mRNA expression ratios in 56 human livers were strongly associated with several variants 2.5-7 kb upstream of the transcription start site (e.g., rs247616 p = 6.4 × 10(-5), allele frequency 33%). In addition, a common alternatively spliced CETP isoform lacking exon 9 (Δ9), has been shown to prevent CETP secretion in a dominant-negative manner. The Δ 9 expression ranged from 10 to 48% of total CETP mRNA in 94 livers. Increased formation of this isoform was exclusively associated with an exon 9 polymorphism rs5883-C>T (p = 6.8 × 10(-10)) and intron 8 polymorphism rs9930761-T>C (5.6 × 10(-8)) (in high linkage disequilibrium with allele frequencies 6-7%). rs9930761 changes a key splicing branch point nucleotide in intron 8, while rs5883 alters an exonic splicing enhancer sequence in exon 9.The effect of these polymorphisms was evaluated in two clinical studies. In the Whitehall II study of 4745 subjects, both rs247616 and rs5883T/rs9930761C were independently associated with increased HDL-C levels in males with similar effect size (rs247616 p = 9.6 × 10(-28) and rs5883 p = 8.6 × 10(-10), adjusted for rs247616). In an independent multiethnic US cohort of hypertensive subjects with CAD (INVEST-GENE), rs5883T/rs9930761C alone were significantly associated with increased incidence of MI, stroke, and all-cause mortality in males (rs5883: OR 2.36 (CI 1.29-4.30), p = 0.005, n = 866). These variants did not reach significance in females in either study. Similar to earlier results linking low CETP activity with poor outcomes in males, our results suggest genetic, sex

  6. Spirulina platensis effects on the levels of total cholesterol, HDL and triacylglycerols in rabbits fed with a hypercholesterolemic diet

    Directory of Open Access Journals (Sweden)

    Luciane Maria Colla

    2008-04-01

    Full Text Available In this work, hypercholesterolemia was induced in rabbits by feeding them a high cholesterol diet (CD, 350 mg/d and the effects of supplementing this diet with 0.5 g/d Spirulina platensis was evaluated by measuring the levels of serum total-cholesterol (TC, triacylglycerols (TAG and high-density lipoprotein (HDL-cholesterol at the start of the experiment and after 30 d and 60 d. It was found that the levels of serum cholesterol decreased from 1,054±101 mg.dL-1 in the rabbits fed a CD without S. platensis to 516±163 mg.dL-1 to those fed with a high cholesterol diet supplemented with S. platensis (significant at p A microalga Spirulina é cultivada e comercializada no mundo devido a suas características nutricionais (elevada concentração de proteínas, em torno de 65%, vitaminas e sais minerais e ao seu potencial terapêutico no tratamento de inúmeras doenças, inclusive a hipercolesterolemia. Neste trabalho foi avaliada a inibição da hipercolesterolemia induzida em coelhos por uma dieta adicionada de colesterol (350 mg.d-1, pela suplementação de 0,5 g.dia-1 de biomassa de Spirulina platensis, sendo avaliados os níveis de colesterol total, triglicerídeos e HDL nos tempos de 0 d, 30 d e 60 d de tratamento. Os resultados indicaram que a adição de Spirulina platensis na dieta ocasionou decréscimo nos níveis de colesterol total de 1054±101 mg.dL-1 para 516±163 mg.dL-1 (p<0,0001, para os coelhos alimentados com a dieta colesterolêmica em comparação com os que receberam a dieta adicionada de Spirulina platensis. A adição de Spirulina a dieta colesterolêmica não ocasionou decréscimo significativo nos níveis de triglicerídios dos coelhos. Os valores de HDL aumentaram de 73±31 mg.dL-1 para 91,0±15,7 mg.dL-1, comparando-se os coelhos alimentados com a dieta colesterolêmica e os alimentados com a dieta adicionada de Spirulina, estatisticamente diferentes a um nível de significância maior que 0,1533.

  7. Espaçamento, densidade e uniformidade de semeadura na produtividade e características agronômicas da soja

    Directory of Open Access Journals (Sweden)

    Tourino Maria Cristina Cavalheiro

    2002-01-01

    Full Text Available O objetivo do presente estudo foi avaliar o efeito do espaçamento entre linhas (45 e 60 cm, da densidade das plantas nas linhas (10, 13, 16, 19 e 22 plantas m-1 e da uniformidade da semeadura (espaçamentos aceitáveis 25%, 35%, 60% e 100%, sobre a produtividade da soja. O experimento foi conduzido nos anos 1997/1998 e 1998/1999, com a cultivar CAC-1. O delineamento experimental utilizado foi o de blocos ao acaso, com três repetições, com os tratamentos em esquema de parcelas sub-subdivididas. Houve aumento na produtividade da soja no espaçamento de 45 cm com a redução da densidade para 10 plantas m-1, e com a uniformidade de espaçamento entre plantas dentro das linhas acima de 60%. A altura das plantas e o grau de acamamento foram reduzidos significativamente; porém, a porcentagem de sobrevivência das plantas aumentou à medida que ocorreu redução da densidade populacional das plantas. Também foi detectado que o aumento da uniformidade de espaçamento entre as plantas dentro das linhas reduziu-lhes o acamamento.

  8. Variação da densidade básica da madeira de progênies de Eucalyptus urophylla em dois locais.

    Directory of Open Access Journals (Sweden)

    Maria Aparecida Mourão Brasil

    2009-09-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 Estudou-se neste trabalho a variação da densidade básica da madeira entre procedências e progênies de eucalipto plantados em duas localidades. As progênies de Eucalyptus urophylla originárias da ilha de Timor na Indonésia foram plantadas em Belo Oriente (MG e Linhares (ES no delineamento de blocos compactos em famílias (compact family blocks com 3 repetições no espaçamento de 3,0 x 2,0m. Após 4 anos as  árvores  foram amostradas ao nível do DAP com a sonda Pressler e sua densidade básica determinada pelo método do máximo teor de umidade. Os resultados mostraram que as progênies tiveram  comportamento similar nos dois locais. A maior variação entre progênies ocorreu naquelas provenientes da região Oebaha II. Os valores médios de densidade básica* das progênies não foram diferentes das procedências brasileiras utilizadas como testemunhas no experimento.

  9. Implementación de un protocolo de alta precoz en pacientes con hemorragia digestiva alta y bajo riesgo de resangrado (1996-2000)

    OpenAIRE

    Ramón Vila, Begoña de

    2004-01-01

    INTRODUCCIÓN:La hemorragia digestiva alta (HDA) es una urgencia médica frecuente. El pronóstico de los pacientes con HDA, así como la duración de la estancia hospitalaria, vienen determinados en gran medida por la persistencia o recidiva de la hemorragia. En los últimos años, varios autores han desarrollado una serie de sistemas de puntuación, basados en criterios clínicos y endoscópicos, para tratar de predecir el riesgo de resangrado o persistencia. Basándonos en el algoritmo propuesto por ...

  10. Implementación de un protocolo de alta precoz en pacientes con hemorragia digestiva alta y bajo riesgo de resangrado (1996-2000)

    OpenAIRE

    Ramón Vila, Begoña de

    2004-01-01

    [spa] INTRODUCCIÓN: La hemorragia digestiva alta (HDA) es una urgencia médica frecuente. El pronóstico de los pacientes con HDA, así como la duración de la estancia hospitalaria, vienen determinados en gran medida por la persistencia o recidiva de la hemorragia. En los últimos años, varios autores han desarrollado una serie de sistemas de puntuación, basados en criterios clínicos y endoscópicos, para tratar de predecir el riesgo de resangrado o persistencia. Basándonos en el algoritmo propues...

  11. log(TG/HDL-C is related to both residual cardiometabolic risk and β-cell function loss in type 2 diabetes males

    Directory of Open Access Journals (Sweden)

    Ahn Sylvie A

    2010-12-01

    Full Text Available Abstract Background T2DM is associated with atherogenic dyslipidemia (AD, defined as decreased HDL-C plus raised triglycerides (TG. AD confers increased risk for CAD, even when LDL-C is at target. AD is rarely assessed due to lack of screening methods consensus. Aim To establish the prevalence and severity of AD from log(TG/HDL-C in T2DM males, and to determine how it relates to cardiometabolic phenotype, glucose homeostasis, micro- and macrovascular complications, and 10-year UKPDS CV risk. Methods 585 T2DM males divided according to quintiles (Q of log(TG/HDL-C. AD prevalence defined as HDL-C -1 plus TG ≥150 mg.dL-1. β-cell function assessed with HOMA. Results Mean HDL-C and TG were 44 (13 and 204 (155 mg.dL-1. AD prevalence was 35%. AD correlated with lower β-cell function, with accelerated loss of insulin secretion, and with poorer HbA1c levels. AD was related to a high prevalence of CAD, and also to 10-year absolute CAD risk. Conclusions log(TG/HDL-C is a simple means to estimate AD and the residual CV risk it confers in T2DM. AD closely associates with major cardiometabolic and glucose homeostasis determinants and poorer metabolic control. The ratio also relates to macroangiopathy prevalence and ranks future CAD risk, and is well-suited to capture non-LDL-related macrovascular residual risk and major glycemic determinants.

  12. A Population Pharmacokinetic/Pharmacodynamic Model Predicts Favorable HDL Cholesterol Changes Over the First 5 Years in Children Treated With Current Efavirenz-Based Regimens.

    Science.gov (United States)

    Homkham, Nontiya; Cressey, Tim R; Ingsrisawang, Lily; Bouazza, Naïm; Ngampiyaskul, Chaiwat; Hongsiriwon, Suchat; Srirojana, Sakulrat; Kanjanavanit, Suparat; Bhakeecheep, Sorakij; Coeur, Sophie Le; Salvadori, Nicolas; Treluyer, Jean Marc; Jourdain, Gonzague; Urien, Saik

    2016-09-01

    Efavirenz use is associated with changes in cholesterol concentrations, but it is unclear whether this effect is related to drug concentrations. Using efavirenz and cholesterol plasma concentrations measured in 87 antiretroviral-naive children in Thailand, we assessed indirect response models to describe the evolution of high- and low-density lipoprotein (HDL, LDL) cholesterol concentrations in relation to efavirenz plasma concentrations over time where efavirenz was assumed to either stimulate cholesterol production or inhibit its elimination. Simulations of cholesterol evolution for children with different average efavirenz concentrations (Cav ) according to their assumed status of "fast" or "slow" metabolizers of efavirenz were performed. At treatment initiation, children's median (interquartile range, IQR) age was 8 years (5 to 10), body mass index z-score 0.01 (-1.05 to 1.44), HDL 31 mg/dL (24 to 44), and LDL 83 mg/dL (69 to 100). Median (IQR) efavirenz Cav was 1.7 mg/L (1.3 to 2.1) during the period of observation. The best model describing the evolution of HDL and LDL cholesterol concentrations over time assumed that efavirenz inhibited their elimination. HDL concentrations increase over 5 years, whereas LDL concentrations increased only during the first 4 months and then returned to baseline levels afterward. Simulations predicted that, after 3 years, HDL would increase to 63 mg/dL in "fast" metabolizers and 97 mg/dL in "slow" metabolizers of efavirenz. The population pharmacokinetic-pharmacodynamic (PK-PD) model shows that favorable HDL cholesterol changes can be expected in children with current efavirenz dosing guidelines over 5 years of treatment. PMID:26749102

  13. The atherogenic dyslipidemia ratio [log(TG/HDL-C] is associated with residual vascular risk, beta-cell function loss and microangiopathy in type 2 diabetes females

    Directory of Open Access Journals (Sweden)

    Hermans Michel P

    2012-10-01

    Full Text Available Abstract Background Atherogenic dyslipidemia (AD, defined as low HDL-C plus elevated triglycerides (TG, comorbid to T2DM, increases cardiometabolic risk for CAD even when LDL-C is at target. In T2DM males, AD was shown to correlate with β-cell function loss, yet it is not established whether this applies across gender. Aim To establish the prevalence and severity of AD in T2DM females, and to determine how it relates to cardiometabolic phenotype, glucose homeostasis, micro- and macrovascular complications, and 10-year absolute CV risk (UKPDS Risk Engine. Methods 340 T2DM females were ranked according to quintiles (Q of the continuous variable log(TG/HDL-C, with AD prevalence defined as HDL-C -1 plus TG ≥150 mg.dL-1, and β-cell function assessed with HOMA. Results AD prevalence was 35%; mean HDL-C and TG were 52 (15 and 160 (105 mg.dL-1. AD was significantly related to central fat, metabolic syndrome, sedentarity and skeletal sarcopenia, as well as to hsCRP, fibrinogen, uric acid, cystatin-C, Big ET-1, and 10-year UKPDS CV risk. AD correlated stepwise with lower β-cell function and hyperbolic product, and with accelerated loss of residual insulin secretion, higher HbA1c and prevalent microangiopathy. Conclusions log(TG/HDL-C is a simple means to grade AD and residual macrovascular risk in T2DM females. This ratio associates with major non-LDL cardiometabolic variables and ranks predicted CAD risk. In addition, log(TG/HDL-C identifies worsening glucose homeostasis, poorer glycemic control, and prevalent microangiopathy.

  14. Assertion based verification methodology for HDL designs of primary sodium pump speed and eddy current flow measurement systems of PFBR

    International Nuclear Information System (INIS)

    With the growing complexity and size of digital designs, functional verification has become a huge challenge. The validation and testing process accounts for a significant percentage of the overall development effort and cost for electronic systems. Many studies have shown that up to 70% of the design development time and resources are spent on functional verification. Functional errors manifest themselves very early in the design flow, and unless they are detected upfront, they can result in severe consequences - both financially and from a safety viewpoint. This paper covers the various types of verification methodologies and focuses on Assertion Based Verification Methodology for HDL designs, taking as case studies, the Primary Sodium Pump Speed and Eddy Current Flow Measurement Systems of PFBR. (author)

  15. Percepção de cuidadores familiares sobre um programa de alta hospitalar Percepciones de los cuidadores familiares sobre el programa de preparo de alta hospitalar Family caregivers' perception about a program of hospital discharge

    OpenAIRE

    Alesssandra Mendonça Cesar; Beatriz Regina Lara dos Santos

    2005-01-01

    O preparo de alta hospitalar, enquanto uma estratégia de Educação em Saúde, pode contribuir para a família dar continuidade aos cuidados no contexto domiciliar, após a alta hospitalar. Este estudo descritivo com abordagem qualitativa objetiva analisar a percepção do cuidador familiar de idosos com Acidente Vascular Cerebral (AVC) em relação a um programa de preparo de alta em um hospital universitário, para isso 12 cuidadores familiares foram entrevistados. Os dados foram analisados conforme ...

  16. Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.

    Directory of Open Access Journals (Sweden)

    Stephen D Turner

    Full Text Available Genome-wide association studies (GWAS are routinely being used to examine the genetic contribution to complex human traits, such as high-density lipoprotein cholesterol (HDL-C. Although HDL-C levels are highly heritable (h(2∼0.7, the genetic determinants identified through GWAS contribute to a small fraction of the variance in this trait. Reasons for this discrepancy may include rare variants, structural variants, gene-environment (GxE interactions, and gene-gene (GxG interactions. Clinical practice-based biobanks now allow investigators to address these challenges by conducting GWAS in the context of comprehensive electronic medical records (EMRs. Here we apply an EMR-based phenotyping approach, within the context of routine care, to replicate several known associations between HDL-C and previously characterized genetic variants: CETP (rs3764261, p = 1.22e-25, LIPC (rs11855284, p = 3.92e-14, LPL (rs12678919, p = 1.99e-7, and the APOA1/C3/A4/A5 locus (rs964184, p = 1.06e-5, all adjusted for age, gender, body mass index (BMI, and smoking status. By using a novel approach which censors data based on relevant co-morbidities and lipid modifying medications to construct a more rigorous HDL-C phenotype, we identified an association between HDL-C and TRIB1, a gene which previously resisted identification in studies with larger sample sizes. Through the application of additional analytical strategies incorporating biological knowledge, we further identified 11 significant GxG interaction models in our discovery cohort, 8 of which show evidence of replication in a second biobank cohort. The strongest predictive model included a pairwise interaction between LPL (which modulates the incorporation of triglyceride into HDL and ABCA1 (which modulates the incorporation of free cholesterol into HDL. These results demonstrate that gene-gene interactions modulate complex human traits, including HDL cholesterol.

  17. Effects of extended-release niacin/laropiprant, simvastatin, and the combination on correlations between apolipoprotein B, LDL cholesterol, and non-HDL cholesterol in patients with dyslipidemia

    Science.gov (United States)

    Farnier, Michel; Chen, Erluo; Johnson-Levonas, Amy O; McCrary Sisk, Christine; Mitchel, Yale B

    2014-01-01

    Background Statins modify correlations between apolipoprotein B (apoB) and low-density lipoprotein cholesterol (LDL-C) and apoB and non-high-density lipoprotein cholesterol (non-HDL-C); however, it is not known whether niacin-based therapies have similar effects. Objective To evaluate the effects of extended-release niacin (ERN)/laropiprant (LRPT), simvastatin (SIMVA), and ERN/LRPT + SIMVA (pooled ERN/LRPT + SIMVA) on apoB:LDL-C and apoB:non-HDL-C correlations in dyslipidemic patients. Methods This post-hoc analysis of a 12-week study evaluated the apoB:LDL-C and apoB:non-HDL-C correlations in dyslipidemic patients randomized equally to double-blind ERN/LRPT 1 g/20 mg, SIMVA 10, 20, or 40 mg, or ERN/LRPT 1 g/20 mg + SIMVA (10, 20, or 40 mg) once daily for 4 weeks. At week 5, doses were doubled in all groups except SIMVA 40 mg (unchanged) and ERN/LRPT 1 g/20 mg + SIMVA 40 mg (switched to ERN/LRPT 2 g/40 mg + SIMVA 40 mg). Simple linear regression analyses were used to calculate LDL-C and non-HDL-C levels corresponding to known apoB baseline values (ie, in untreated patients) and following treatment. Results The apoB:LDL-C and apoB:non-HDL-C correlations were higher and the predicted LDL-C and non-HDL-C levels for a known apoB value were considerably lower following treatment with ERN/LRPT, SIMVA and ERN/LRPT + SIMVA compared with untreated patients at baseline. Conclusion Greater dissociation of apoB, LDL-C, and non-HDL-C targets occur following treatment with ERN/LRPT, SIMVA, and ERN/LRPT + SIMVA in patients with dyslipidemia. The achievement of more aggressive LDL-C and non-HDL-C goals in patients receiving lipid-modifying therapy may further reduce coronary risk by normalizing apoB-containing atherogenic lipoproteins. PMID:24855368

  18. Total physical activity might not be a good measure in the relationship with HDL cholesterol and triglycerides in a multi-ethnic population: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    de Munter Jeroen SL

    2011-11-01

    Full Text Available Abstract Background Evidence suggests that physical activity (PA has a beneficial effect on high-density lipoprotein cholesterol (HDL and triglycerides. However, observational studies show contrasting results for this association between different ethnic groups. It is unclear whether this is due to differences in the PA composition. The aim of this study was to assess the relationship of the total PA, along with its intensity and duration, with HDL and triglycerides in a multi-ethnic population. Methods The study population was sampled from the SUNSET study and included: 502 European- Dutch, 338 Hindustani-Surinamese, and 596 African-Surinamese participants living in Amsterdam, the Netherlands. We assessed PA with the SQUASH questionnaire. We calculated age-sex-adjusted betas, geometric mean ratios (GMRs, and prevalence ratios (PRs to assess the relationship of PA with HDL and triglycerides. Results In the adjusted models, the highest total PA tertile compared to the lowest tertile was beneficially associated with HDL (beta: 0.08, 95% CI: 0.00, 0.16 and PR low HDL 0.59, 95% CI: 0.39, 0.88 and triglycerides (GMR: 0.93, 95% CI: 0.83, 1.03 and PR: 0.56, 95% CI: 0.29, 1.08 for the African-Surinamese. No statistically significant associations appeared for total PA among the European-Dutch and Hindustani-Surinamese. The adjusted models with the intensity score and HDL showed beneficial associations for the European-Dutch (beta: 0.06, 95% CI: 0.03, 0.10 and African-Surinamese (beta: 0.06, 0.02, 0.10, for log triglycerides for the European-Dutch (beta: -0.08, 95% CI: -0.12, 0.03, Hindustani-Surinamese (beta: -0.06, 95% CI: -0.16, 0.03, and African-Surinamese (beta: -0.04, 95% CI: -0.10, 0.01. Excepting HDL in African-Surinamese, the duration score was unrelated to HDL and triglycerides in any group. Conclusions Activity intensity related beneficially to blood lipids in almost every ethnic group. The activity duration was unrelated to blood lipids, while

  19. Assessment of the Effect of Gene Polymorphisms and Environmental Risk Factors on Low HDL Over Time: Tehran Lipid and Glucose Study

    Directory of Open Access Journals (Sweden)

    Mehrabi Yadollah

    2015-07-01

    Full Text Available Objective: Due to existing association between high-density lipoprotein (HDL and cardiovascular disease, detection of factors affecting this lipid is important. Environmental factors and genetic variations have an important role in HDL level. The effects of these risk factors can be time-dependent; so, study of their effects on HDL level over time is important. In this study, we used transition model to analyze binary longitudinal data to investigate single nucleotide polymorphism (SNP and other risk factors affecting low HDL over time. Materials and Methods: Data of 329 participants of 3 phases of Tehran Lipid and Glucose Study (TLGS was analyzed using marginal transition model. This model has a formulation which allows first and second order Markov dependence to take into account the correlation among successive observations of the same individual in longitudinal binary response for which the marginal probability of success is modelled via a form of logistic regression. Results: Results of first order transition model showed that the odds ratio (OR for having low HDL in women compared to men was 1.54 (95% CI: 1.02, 2.24. High waist circumference (OR = 1.67, CI 95%: 1.16, 2.39, high blood pressure (OR = 0.59, 95% CI: 0.41, 0.85, high triglyceride (OR = 1.85, 95% CI: 1.30, 2.65 and being homozygous for the minor allele of SRB1 (OR = 0.11, 95% CI: 0.01, 0.74 were significantly associated with low HDL. Also, the OR of low HDL in phase 2 of study compared to phase 1 was 1.76 (95% CI: 1.32, 2.35. The result of second order transition model was fairly similar to first order. The parameter estimates of serial dependency are markedly significant, pointing clearly to a first and second-order serial dependence (P < .001. Conclusion: Considering the identification of genetic and environmental factors affecting low HDL over time, transition model was used and the most important risk factors were identified.

  20. Densidade de estocagem de juvenis de tambaqui durante a recria em tanques-rede Stocking density of tambaqui juveniles during second growth phase in cages

    Directory of Open Access Journals (Sweden)

    Franmir Rodrigues Brandão

    2004-04-01

    Full Text Available O objetivo deste trabalho foi determinar a densidade de estocagem mais adequada para a fase de recria de juvenis de tambaqui (Colossoma macropomum em tanque-rede. Foram utilizados 12 tanques-rede de 1 m³ cada, com peixes distribuídos nas densidades de 200, 300, 400 e 500 peixes/m³ em três repetições. Os peixes foram alimentados seis vezes por semana em três refeições diárias com ração comercial com 36% de proteína bruta, durante 60 dias. Foram analisados o crescimento em peso e em comprimento, o coeficiente de variação do comprimento, a taxa de crescimento específico e a glicose sanguínea aos 30 e 60 dias de criação. Ao final do experimento, foram analisados os seguintes parâmetros de produtividade: sobrevivência, conversão alimentar aparente, ganho de peso e produção por área. Os parâmetros físico-químicos da água foram avaliados a cada sete dias. O crescimento em peso e em comprimento, aos 60 dias, foi maior na densidade de 200 peixes/m³ do que na de 500 peixes/m³. O coeficiente de variação, a taxa de crescimento específico e a glicose não diferiram entre as densidades aos 30 e 60 dias. A sobrevivência final, a conversão alimentar aparente e o ganho de peso foram iguais em todas as densidades. A produção por área foi significativamente maior nas duas maiores densidades. Os resultados indicaram que a densidade de 400 peixes/m³ é a mais adequada para recria de juvenis de tambaqui em tanque-rede.The objective of this work was to determine the adequate stocking density to second growth phase of tambaqui (Colossoma macropomum juveniles in cage. Twelve cages of 1 m³ were used to stock fish in four different densities, with three replicate: 200, 300, 400 and 500 fish/m³. Fish were fed with commercial diets with 36% of crude protein six times a week, in three daily meals during 60 days. The growth in weight and in length, coefficient of variation of length, specific growth rate and glucose were analyzed at

  1. Recomendaciones europeas para el empleo de tornillos de alta resistencia en las estructuras de acero

    Directory of Open Access Journals (Sweden)

    Batanero, J.

    1962-10-01

    Full Text Available Con el enlace de los perfiles de acero por medio de tornillos de alta resistencia, pretensados, se ha introducido en la construcción metálica un nuevo tipo de uniones, que resisten por rozamiento. Los tomillos de alta resistencia (exceptuados los calibrados deberán quedar en el agujero con una cierta holgura; y, mediante apretadura de la tuerca o de la cabeza, tensarse en forma que las superficies de contacto de las piezas unidas quedan fuertemente presionadas, una contra otra, muy especialmente en las proximidades del agujero. Con ello el esfuerzo que actúa perpendicularmente al eje del tomillo es resistido por el rozamiento estático entre las superficies unidas; en tanto que, como consecuencia, la espiga del tomillo queda sometida a una tracción axil y a una torsión.

  2. Metais pesados, densidade e atividade microbiana em solo contaminado por rejeitos de indústria de zinco

    Directory of Open Access Journals (Sweden)

    H. E. Dias-Júnior

    1998-12-01

    Full Text Available As atividades relacionadas com mineração e indústria metalúrgica são responsáveis pela poluição de extensas áreas de solo em todo o mundo, sendo seus efeitos ainda pouco conhecidos nas condições brasileiras. No presente trabalho, os teores totais e solúveis em água de metais pesados, a densidade e a atividade microbiana foram avaliados em 1996, em sete locais de uma área de deposição de rejeitos da industrialização de zinco, em elevado estádio de degradação, e num local fora da área contaminada, considerado como referência, no estado de Minas Gerais. Todos os locais contaminados apresentaram elevados teores de metais pesados totais e solúveis em água, atingindo, respectivamente, os seguintes valores máximos, em mg kg-1: 11.969 e 726 de Zn; 109 e 18 de Cd; 1.016 e 0 de Pb e 887 e 8 de Cu. Todas as características biológicas avaliadas foram afetadas pelos elevados teores de metais com exceção do número de amonificadores. O C-biomassa apresentou redução acima de 80% em quatro locais contaminados em relação ao local fora da área contaminada. A respiração basal do solo foi maior no local contaminado coberto com Andropogon sp. e menor nos sítios sem vegetação. O número de actinomicetos e de fungos cultiváveis foi menos afetado pela contaminação que o número total de bactérias. Azospirillum spp. foram detectados apenas no local de referência. Oxidantes de amônio foram verificados em somente dois locais que continham vegetação, enquanto os oxidantes de nitrito foram detectados na maioria dos locais amostrados. Verificou-se a tendência de maior densidade e atividade microbiana nos locais contaminados e com algum tipo de vegetação. A concentração total e solúvel de Zn, de Cd e de Cu correlacionou-se fracamente com as características biológicas, exceto para o qCO2, o qual se mostrou promissor como indicador da contaminação com esses metais. Os dados indicaram uma interação qu

  3. Studio di approfondimento sullo stato di salute nei Comuni dell'Alta Val di Cecina

    OpenAIRE

    Romanelli, Anna Maria; Bartolacci, Simone; Capocchi, Rachele; Mariani, Silvia; Minichilli, Fabrizio; Protti, Maria Angela; Salvadori, Patrizia; Tacconi, Giorgia; Vigotti, Maria Angela; Bianchi, Fabrizio

    2009-01-01

    Uno studio preliminare sull'Alta Val di Cecina, AVC, (Pisa) aveva evidenziato che tra le cause di morte, 1970-2004, alcune avevano un impatto pi? elevato o in controtendenza rispetto alla media regionale toscana; l'area presenta un sottosuolo geologicamente attivo, industrie chimiche, di produzione di energia, estrattive, documentate contaminazioni di acqua e suolo da metalli pesanti. Si segnalano eccessi di mortalit? e/o di ospedalizzazione per alcune patologie per le quali in letteratura ri...

  4. Inbreeding incidence on biological fitness in an isolated Mediterranean population: La Alta Alpujarra Oriental (Southeastern Spain)

    OpenAIRE

    Luna, Francisco; Valls, A.; Fernández Santander, Ana

    1998-01-01

    The incidence of parental inbreeding on biological fitness was analysed in a sample of the Alpujarrenian population. Fitness was estimated as the fertility and offspring viability from conception to reproductive age. The analysed sample represents about 45% of the population from the Alta Alpujarra Oriental in southeastern Spain, and includes 847 families and 2916 pregnancies. The results showed slightly higher reproduction in consanguineous marriages, but the differences observed were not st...

  5. Procesos de automatización cognitiva en alumnado con altas capacidades intelectuales

    Directory of Open Access Journals (Sweden)

    Juan Montero-Linares

    2013-05-01

    Full Text Available Proponemos desde el enfoque del procesamiento de la información, el estudio de características cognitivas que faciliten la identificación de las altas capacidades. A tal fin, elaboramos una tarea de habilidad de segmentación silábica que, a partir del modelo propuesto por Baddeley sobre la memoria de trabajo y la distinción entre procesos automáticos y controlados, nos permitiese comprobar las diferencias en cuanto a la capacidad de automatización de la información y si los indicadores propuestos en la misma, tenían suficiente poder clasificatorio o predictivo en la identificación de la alta capacidad intelectual. Participaron 480 niños y niñas de primero a cuarto de Educación Primaria. Se clasificaron, en función de su CI, en dos grupos: alumnado de altas capacidades y alumnado de capacidades medias. Se les administró una batería de pruebas entre las que se encontraba el test de habilidad de segmentación silábica, lo que permitió realizar su estandarización. Los resultados mostraron que los alumnos con CI superior a 130 fueron capaces de automatizar la segmentación de forma más eficiente que los de inteligencia media. La medición de los procesos automáticos a través del test de habilidad de segmentación silábica, permitió diferenciar a los participantes de altas capacidades de los que no lo eran.

  6. Neurossífilis resistente a altas doses de penicilina: registro de um caso

    Directory of Open Access Journals (Sweden)

    Ricardo Nitrini

    1984-03-01

    Full Text Available É relatado caso de paciente com neurossífilis que apresentou deterioração clínica e persistência de alterações do líquido cefalorraqueano após repetidas tentativas terapêuticas com altas doses de penicilina. Tratamento com cloranfenicol resultou em estabilização do quadro clínico e melhora laboratorial.

  7. Vital Signs – Presión arterial alta (High Blood Pressure)

    Centers for Disease Control (CDC) Podcasts

    2012-10-02

    En los EE. UU. casi un tercio de la población adulta tiene presión arterial alta, el principal factor de riesgo de enfermedades cardiacas y accidentes cerebrovasculares, dos de las principales causas de muerte en el país.  Created: 10/2/2012 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/17/2012.

  8. Basic specific gravity and anatomy of Peltophorum dubium wood as a function of provenance and radial position. Densidade aparente e anatomia da madeira de Peltophorum dubium em função da procedência e posição radial.

    Directory of Open Access Journals (Sweden)

    Israel Luiz de LIMA

    2015-06-01

    da madeira em comparação com as características externas mais sensíveis a estresses ambientais, como as folhas. Com base na literatura e em nossos resultados anteriores, a variação radial em P. dubium foi semelhante à encontrada em muitas espécies nativas, incluindo, por exemplo, aumento na densidade aparente, comprimento e espessura da parede das fibras, aumento no diâmetro e diminuição na frequência de vasos na direção da casca. Concluímos que P. dubium tem alta adaptabilidade em diferentes locais e que a consistência na qualidade de sua madeira pode ser mantida entre procedências, com implicações concomitantes, tanto para produção quanto para a utilização.

  9. Avaliação de germoplasma de camomila e densidade de semeadura na produção e composição do óleo essencial Evaluation of germplasm and seeding rate over the production and composition of chamomile essential oil

    Directory of Open Access Journals (Sweden)

    Wanderlei do Amaral

    2012-06-01

    Full Text Available O cultivo de camomila na região Sul do Brasil tem sido realizado utilizando-se como material genético a cultivar Mandirituba. Apesar da produção de capítulos florais e teor de óleos essenciais apresentado por esta cultivar ser considerado satisfatório, tem sido observada nas regiões produtoras a ocorrência de problemas fitossanitários que resultam em perdas significativas da produção. Este trabalho teve como objetivos comparar materiais genéticos de camomila provenientes da Holanda, Dinamarca e Mandirituba, e avaliar o efeito de diferentes densidades de semeadura no desenvolvimento das plantas, produção de capítulos, rendimento e qualidade do óleo essencial da cultivar Mandirituba, atualmente cultivada na região. Os experimentos foram conduzidos no município de Piraquara (PR. A extração do óleo essencial foi realizada por hidrodestilação em aparelho tipo Clevenger e a determinação da composição do óleo foi feita por cromatografia em fase gasosa acoplada ao espectrômetro de massa (GC/MS. Os materiais genéticos provenientes da Holanda e de Mandirituba apresentaram maior produção de biomassa seca de capítulos, em relação ao material genético da Dinamarca. A cultivar Mandirituba apresentou o maior rendimento de óleo essencial (4,71 mL g-1 ms, sendo também superior em relação à produtividade de óleo essencial (2,40 L ha-1. Os materiais procedentes da Dinamarca e de Mandirituba apresentaram composição do óleo essencial semelhantes. A densidade de plantio de 1,0 kg ha-1 da cultivar Mandirituba resultou em melhor desenvolvimento das plantas e maior produção de óleo essencial. Quantidades superiores a 3,0 kg ha-1 de sementes não resultaram em maior densidade de plantas tendo em vista a alta competição e percentual de plântulas mortas.The cultivar Mandirituba is the only genetic material for chamomile cultivation in southern Brazil. Besides the limitations regarding floral buds and the yield of

  10. Funcionalización de polietileno de baja densidad con anhídrido maleico en estado fundido

    Directory of Open Access Journals (Sweden)

    Manuel Guzmán

    2014-01-01

    Full Text Available En este estudio, polietileno de baja densidad (PEBD fue modificado con anhídrido maleico (AM en estado fundido usando concentraciones diferentes de peróxido de dicumilo (DCP (0.25, 0.50, 0.75 y 1.0 %. Los materiales obtenidos fueron caracterizados por contenido de gel, titulaciones ácido-base, análisis infrarrojo (IR, calorimetría de barrido diferencial (DSC, análisis termogravimétrico (TGA, análisis reológico, propiedades mecánicas, dureza y permeabilidad al oxígeno. El análisis reométrico indicó que el tiempo óptimo para obtener las mezclas es alrededor de 7.5 minutos. El análisis IR mostró que el AM fue injertado en el esqueleto del PEBD, el grado de injerto incrementó con el contenido de DCP y el más alto grado de injerto (1.12 ± 0.015 %, fue exhibido por la muestra obtenida empleando la mayor cantidad de DCP (1 %. La estabilidad térmica de las muestras funcionalizadas fue ligeramente mayor que la del PEBD. La cristalinidad de las muestras funcionalizadas fue diferente a la exhibida por el PEBD. El comportamiento reológico presentado por las muestras fue seudoplástico. Las propiedades mecánicas, dureza y la permeabilidad al oxigeno fueron dependientes de la cantidad de DCP y AM injertado en el PEBD.

  11. HDL particle size and the risk of coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study

    NARCIS (Netherlands)

    B.J. Arsenault; I. Lemieux; J.P. Després; P. Gagnon; N.J. Wareham; E.S.G. Stroes; J.J.P. Kastelein; K.T. Khaw; S.M. Boekholdt

    2009-01-01

    Objective: To evaluate the association between HDL particle size measured by gradient gel electrophoresis and risk of incident coronary heart disease (CHD) in apparently healthy men and women. Methods: We performed a prospective case-control study nested in the EPIC-Norfolk cohort. Cases were appare

  12. Gender and age specific differences in the kinetic behavior of TRL, IDL and LDL apolipoprotein B-100 and HDL apolipoprotein A-I

    Science.gov (United States)

    Gender specific differences in lipid and lipoprotein profile, predominantly higher LDL-C, VLDL-C and TG, and lower HDL-C levels have been observed in males compared to females. These differences are influenced by menopausal status and age. To investigate mechanism(s) involved, apolipoprotein (apo) B...

  13. ESTRUTURA E POTENCIAL FUTURO DE UTILIZAÇÃO DA REGENERAÇÃO NATURAL DE FLORESTA DE VÁRZEA ALTA NO MUNICÍPIO DE AFUÁ, ESTADO DO PARÁ

    Directory of Open Access Journals (Sweden)

    José Roberto Soares Scolforo

    2003-05-01

    Full Text Available O presente estudo teve como objetivo analisar a estrutura e indicar as probabilidade de utilização futura da regeneração natural de uma floresta não-explorada de várzea alta localizada no município de Afuá (0° 09’ 24” S e 50° 23’ 12” W, ao norte do estado do Pará. Foram amostradas 29 subparcelas de 100 m2 nas quais se mediu a altura (h de árvores e palmeiras com h  0,30 m até o diâmetro a 1,30 m do nível do solo (DAP  15 cm, e o diâmetro das árvores compreendidas entre h  3,0 m até DAP  15 cm. A densidade total foi 30.969 indivíduos/ha, pertencentes a setenta espécies, 57 gêneros e 25 famílias botânicas, com índice de diversidade de Shannon (H’ de 2,68. As espécies mais importantes foram: Virola surinamensis, Euterpe oleracea, Astrocaryum murumuru, Geonoma laxiflora e Guarea guidonia. Muitas espécies são utilizadas como alimento pela fauna local, além de servirem como fonte de madeira e/ou, de produtos florestais não-madeireiros; algumas destas funcionam como complementação à dieta alimentar dos ribeirinhos, tais como: Eschweilera coriacea, Gustavia augusta, Inga Alba, Nectandra cf. risi e Protium spruceanum.

  14. Las variaciones en colesterol-HDL tras bypass gástrico proximal son independientes de la evolución ponderal

    Directory of Open Access Journals (Sweden)

    S. Laguna

    2016-01-01

    Full Text Available Fundamento. La cirugía bariátrica posee efectos beneficiosos sobre el perfil lipídico en pacientes con obesidad mórbida que pueden atenuarse con la recuperación ponderal. El presente estudio se ha llevado a cabo para evaluar el perfil lipídico antes y a lo largo de los seis años consiguientes a la realización de bypass gástrico proximal (BPG. Material y métodos. Se han estudiado 177 pacientes (135 mujeres con obesidad mórbida (IMC 44,2+0,4 kg/m² de 42,4+0,9 años de edad antes, 3,6,9, 12,24,36,48,60 y 72 meses después de realizar BPG. En todas las revisiones se evaluó el tratamiento hipolipemiante, antropometría (IMC, cintura, composición corporal (Bod-Pod y determinaciones de colesterol total (CT, colesterol-LDL (LDL-C, colesterol-HDL (HDL-C, triglicéridos (TG, glucosa e insulina. Resultados. El BPG indujo marcada reducción de IMC (nadir IMC a 18 meses 28,3+0,4 kg/m² p<0,001 y grasa corporal consiguiendo una pérdida de exceso IMC del 84,1% y del exceso de porcentaje de grasa del 87% que disminuyó al 65,6 y 38,3% (ambos p<0,005 respecto a nadir respectivamente a los 6 años del BPG, indicando recuperación de peso y grasa corporal. Los valores de TG alcanzaron el 70% a los 60 meses, los de LDL-C el 70,6% a los 18 meses y los de HDL-C el 197% del valor pre-intervención a los 48 meses. La elevación de HDL-C aumentó durante la fase de recuperación ponderal de forma continuada (p<0,001. Tanto los cocientes CT/HDL-C como TG/HDL-C se normalizaron de forma mantenida durante los 6 años de seguimiento. Conclusiones. Estos resultados confirman la mejoría de todas las fracciones lipídicas 6 años después del BPG, con especial mención a HDL-C, que mantuvo progresión creciente incluso durante la recuperación ponderal, reduciendo la tasa de dislipemia a los 6 años del BPG.

  15. Anestesia espinal alta para mastoplastia reductora. Experiencia de tres años

    Directory of Open Access Journals (Sweden)

    Néstor Parets Correa

    2012-05-01

    Full Text Available Fundamento: la aplicación de anestesia neuroaxial espinal alta en las intervenciones quirúrgicas resulta un tema controversial. Objetivo: describir los resultados de la aplicación de anestesia neuroaxial espinal alta en intervenciones quirúrgicas para mastoplastia reductora. Métodos: estudio descriptivo realizado en el Hospital General Universitario Dr. Gustavo Aldereguía Lima, de Cienfuegos, desde junio de 2006 hasta junio de 2009, que incluyó 90 pacientes operadas, en las cuales se empleó anestesia neuroaxial espinal alta. Se analizaron las variables: edad, índice de masa corporal, saturación de HBO2, tensión arterial, frecuencia cardiaca, uso de analgesia preventiva, comportamiento de la  analgesia posoperatoria, estado de satisfacción, presencia de complicaciones, técnica quirúrgica, duración del acto quirúrgico y de la anestesia. Resultados: el 50 % tenía  entre 35 y 44 años; 46, 7 % estaban sobrepeso; el 80 % se operó de hipertrofia mamaria; en el 97, 8 % se utilizó la mastopalstia reductora; ninguna presentó cifras altas de tensión arterial antes ni después de la aplicación de la anestesia, el 41,1 % presentó cifras bajas de tensión arterial después de la anestesia; la frecuencia cardiaca estuvo baja en el 31, 1 % después de aplicada la anestesia y alta en el 4, 4 %. La analgesia posoperatoria fue buena en el 87, 8 % de las pacientes; no hubo compromiso ventilatorio en ningún caso y el 100 % mostró satisfacción con la técnica anestésica. Conclusiones: la aplicación de la técnica anestésica permite desarrollar exitosamente las intervenciones quirúrgicas con un mínimo de riesgos y complicaciones para las pacientes.

  16. An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI

    Directory of Open Access Journals (Sweden)

    Xuelei Song, Paul Fischer, Xun Chen, Charlotte Burton, Jun Wang

    2009-01-01

    Full Text Available Apolipoprotein A-I (apoA-I mimetic peptides have been pursued as new therapeutic agents for the treatment of atherosclerosis, yet their precise mechanism responsible for atheroprotection remains unclear. Like apoA-I itself, most of these peptides are capable of stimulating cholesterol efflux from macrophages or foam cells, and some of them stimulate lecithin cholesterol acyltransferase (LCAT activity in the reverse cholesterol transport (RCT pathway. However, the ability of mimetic peptides to deliver cholesterol into hepatocytes (off-loading, the last step of the RCT pathway, has not been demonstrated. In this study, we compared a mimetic peptide D-4F to purified apoA-I, to address the role that mimetics play during the off-loading process. Both D-4F and apoA-I formed spherical nano-particles when reconstituted with cholesteryl ester and phospholipids. Compared to apoA-I, D-4F particles were 20 times more efficient in off-loading cholesterol to HepG2 hepatocytes with an apparent Kt (transport of 0.74 μg/mL. Furthermore, D-4F also facilitated cholesteryl ester offloading from HDL particles into HepG2 cells when it was pre-incubated with these HDL particles. Using an inducible HEK293 cell line, we demonstrated that these nano-particles were able to be taken up through SR-BI, a HDL selective receptor. Cholesterol uptake by HepG2 cells was completely blocked by a neutralizing monoclonal antibody against SR-BI, demonstrating that D-4F particles, similar to HDL, specifically off-loaded cholesterol through SR-BI. Overall our data provides evidence that D-4F is capable of mimicking apoA-I to form HDL-like particles, and off-loads cholesterol for catabolism and excretion, thus completing RCT.

  17. VNN1 Gene Expression Levels and the G-137T Polymorphism Are Associated with HDL-C Levels in Mexican Prepubertal Children

    Science.gov (United States)

    Jacobo-Albavera, Leonor; Aguayo-de la Rosa, Pablo I.; Villarreal-Molina, Teresa; Villamil-Ramírez, Hugo; León-Mimila, Paola; Romero-Hidalgo, Sandra; López-Contreras, Blanca E.; Sánchez-Muñoz, Fausto; Bojalil, Rafael; González-Barrios, Juan Antonio; Aguilar-Salinas, Carlos A.; Canizales-Quinteros, Samuel

    2012-01-01

    Background VNN1 gene expression levels and the G-137T polymorphism have been associated with high density lipoprotein cholesterol (HDL-C) levels in Mexican American adults. We aim to evaluate the contribution of VNN1 gene expression and the G-137T variant to HDL-C levels and other metabolic traits in Mexican prepubertal children. Methodology/Principal Findings VNN1 mRNA expression levels were quantified in peripheral blood leukocytes from 224 unrelated Mexican-Mestizo children aged 6–8 years (107 boys and 117 girls) and were genotyped for the G-137T variant (rs4897612). To account for population stratification, a panel of 10 ancestry informative markers was analyzed. After adjustment for admixture, the TT genotype was significantly associated with lower VNN1 mRNA expression levels (P = 2.9 × 10−5), decreased HDL-C levels (β = −6.19, P = 0.028) and with higher body mass index (BMI) z-score (β = 0.48, P = 0.024) in the total sample. In addition, VNN1 expression showed a positive correlation with HDL-C levels (r = 0.220; P = 0.017) and a negative correlation with BMI z-score (r = −0.225; P = 0.015) only in girls. Conclusion/Significance Our data suggest that VNN1 gene expression and the G-137T variant are associated with HDL-C levels in Mexican children, particularly in prepubertal girls. PMID:23185446

  18. Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity

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    Elad Cohen

    2012-01-01

    Full Text Available Human carotid plaque components interact directly with circulating blood elements and thus they might affect each other. We determined plaque paraoxonase1 (PON1 hydrolytic-catalytic activity and compared plaque and blood levels of lipids, HDL, PON1, and HbA1c, as well as plaque-oxidized lipids in symptomatic and asymptomatic patients. Human carotid plaques were obtained from symptomatic and asymptomatic patients undergoing routine endarterectomy, and the lesions were ground and extracted for PON activity and lipid content determinations. Plaque PONs preserved paraoxonase, arylesterase, and lactonase activities. The PON1-specific inhibitor 2-hydroxyquinoline almost completely inhibited paraoxonase and lactonase activities, while only moderately inhibiting arylesterase activity. Oxysterol and triglyceride levels in plaques from symptomatic and asymptomatic patients did not differ significantly, but plaques from symptomatic patients had significantly higher (135% linoleic acid hydroperoxide (LA-13OOH levels. Their serum PON1 activity, cholesterol and triglyceride levels did not differ significantly, but symptomatic patients had significantly lower (28% serum HDL levels and higher (18% HbA1c levels. Thus LA-13OOH, a major atherogenic plaque element, showed significant negative correlations with serum PON1 activity and HDL levels, and a positive correlation with the prodiabetic atherogenic HbA1c. Plaque PON1 retains its activity and may decrease plaque atherogenicity by reducing specific oxidized lipids (e.g., LA-13OOH. The inverse correlation between plaque LA-13OOH level and serum HDL level and PON1 activity suggests a role for serum HDL and PON1 in LA-13OOH accumulation.

  19. Lp(a-cholesterol is associated with HDL-cholesterol in overweight and obese African American children and is not an independent risk factor for CVD

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    Sharma Sushma

    2012-01-01

    Full Text Available Abstract Background The role of Lipoprotein (a cholesterol {Lp(a-C}as an additional and/or independent risk factor for cardiovascular disease (CVD is not clear. We evaluated the associations between Lp(a-C and other CVD risk factors including plasma lipoprotein concentrations and body fatness in overweight and obese African American children. Methods A cross-sectional analysis was carried out using data from a sample of 121 African American children aged 9-11 years with Body Mass Index (BMI's greater than the 85th percentile. Body height, weight and waist circumference (WC were measured. Fasting plasma concentrations of Lp(a-C, Total cholesterol (TC, High density lipoprotein cholesterol (HDL-C, Very low density lipoprotein cholesterol (VLDL-C, Intermediate density lipoprotein cholesterol (IDL-C, Low density lipoprotein cholesterol (LDL-C, and Triacylglycerides (TAG were analyzed using the vertical auto profile (VAP cholesterol method. Results After adjusting for child age, gender, and pubertal status, Lp(a-C was positively associated with both HDL-C and TC, and negatively associated with VLDL-C and TAG. Including BMIz and WC as additional covariates did not alter the direction of the relationships between Lp(a-C and the other lipoproteins. Finally, after adjusting for the other plasma lipoproteins, Lp(a-C remained strongly associated with HDL-C, whereas the associations of Lp(a-C with the other lipoproteins were not significant when HDL-C was simultaneously included in the regression models. Conclusions Lp(a-C was positively associated with HDL-C and this association is not influenced by other lipoprotein subclasses or by the degree of obesity. We conclude that Lp(a cholesterol is not an independent risk factor for CVD in African American children.

  20. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials

    NARCIS (Netherlands)

    Mensink, R.P.; Zock, P.L.; Kester, A.D.M.; Katan, M.B.

    2003-01-01

    Background: The effects of dietary fats on the risk of coronary artery disease (CAD) have traditionally been estimated from their effects on LDL cholesterol. Fats, however, also affect HDL cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is LDL cholesterol

  1. Multiple splice defects in ABCA1 cause low HDL-C in a family with Hypoalphalipoproteinemia and premature coronary disease

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    Miller Michael

    2009-01-01

    Full Text Available Abstract Background Mutations at splice junctions causing exon skipping are uncommon compared to exonic mutations, and two intronic mutations causing an aberrant phenotype have rarely been reported. Despite the high number of functional ABCA1 mutations reported to date, splice variants have been reported infrequently. We screened DNA from a 41 year-old male with low HDL-C (12 mg/dL [0.31 mmol/L] and a family history of premature coronary heart disease (CHD using polymerase chain reaction single-strand conformation polymorphism (SSCP analysis. Methods Family members with low levels of HDL-C (n = 6 were screened by SSCP for mutations in ABCA1. Samples with altered SSCP patterns were sequenced directly using either an ABI 3700 or ABI3730Xl DNA Analyzer. To screen for splicing defects, cDNA was isolated from the proband's RNA and was sequenced as above. A series of minigenes were constructed to determine the contribution of normal and defective alleles. Results Two novel splice variants in ABCA1 were identified. The first mutation was a single base pair change (T->C in IVS 7, 6 bps downstream from the exon7/intron7 junction. Amplification of cDNA and allelic subcloning identified skipping of Exon 7 that results in the elimination of 59 amino acids from the first extracellular loop of the ABCA1 protein. The second mutation was a single base pair change (G->C at IVS 31 -1, at the intron/exon junction of exon 32. This mutation causes skipping of exon 32, resulting in 8 novel amino acids followed by a stop codon and a predicted protein size of 1496 AA, compared to normal (2261 AA. Bioinformatic studies predicted an impact on splicing as confirmed by in vitro assays of constitutive splicing. Conclusion In addition to carnitine-acylcarnitine translocase (CACT deficiency and Hermansky-Pudlak syndrome type 3, this represents only the third reported case in which 2 different splice mutations has resulted in an aberrant clinical phenotype.

  2. Multiple splice defects in ABCA1 cause low HDL-C in a family with Hypoalphalipoproteinemia and premature coronary disease

    Science.gov (United States)

    Rhyne, Jeffrey; Mantaring, Myrna M; Gardner, David F; Miller, Michael

    2009-01-01

    Background Mutations at splice junctions causing exon skipping are uncommon compared to exonic mutations, and two intronic mutations causing an aberrant phenotype have rarely been reported. Despite the high number of functional ABCA1 mutations reported to date, splice variants have been reported infrequently. We screened DNA from a 41 year-old male with low HDL-C (12 mg/dL [0.31 mmol/L]) and a family history of premature coronary heart disease (CHD) using polymerase chain reaction single-strand conformation polymorphism (SSCP) analysis. Methods Family members with low levels of HDL-C (n = 6) were screened by SSCP for mutations in ABCA1. Samples with altered SSCP patterns were sequenced directly using either an ABI 3700 or ABI3730Xl DNA Analyzer. To screen for splicing defects, cDNA was isolated from the proband's RNA and was sequenced as above. A series of minigenes were constructed to determine the contribution of normal and defective alleles. Results Two novel splice variants in ABCA1 were identified. The first mutation was a single base pair change (T->C) in IVS 7, 6 bps downstream from the exon7/intron7 junction. Amplification of cDNA and allelic subcloning identified skipping of Exon 7 that results in the elimination of 59 amino acids from the first extracellular loop of the ABCA1 protein. The second mutation was a single base pair change (G->C) at IVS 31 -1, at the intron/exon junction of exon 32. This mutation causes skipping of exon 32, resulting in 8 novel amino acids followed by a stop codon and a predicted protein size of 1496 AA, compared to normal (2261 AA). Bioinformatic studies predicted an impact on splicing as confirmed by in vitro assays of constitutive splicing. Conclusion In addition to carnitine-acylcarnitine translocase (CACT) deficiency and Hermansky-Pudlak syndrome type 3, this represents only the third reported case in which 2 different splice mutations has resulted in an aberrant clinical phenotype. PMID:19133158

  3. Rural Electrification of Coban Municipality, Alta Verapaz Department (Guatemala) using Intigis Model; Electrificacion Rural en el Municipio de Coban, Departamento de Alta Verapaz (Guatemala) segun el Modelo Intigis

    Energy Technology Data Exchange (ETDEWEB)

    Dominguez Bravo, J.; Pinedo Pascua, I.; Auger Campos, C.; Cedillo Heine, A.; Gil Garcia, M.

    2009-05-15

    The present project started as an educational exercise for the Renewable Energies and Environment Masters given by the Polytechnic University of Madrid (UPM). It has been developed in collaboration with the research centre CIEMAT, the NGO Energy without Borders (ESF) and the University UPM, with the purpose of analyzing in a real context the application of Geographic Information Systems in renewable energies regional integration. The final aim of our study is to provide the isolated communities, specifically 13 communities in Alta Verapaz (Department of Coban, Guatemala), with the necessary conditions of electrification. This improvement will make possible the sustainable development of the area. Through the analysis of the geographic, technical and economic information gathered, using the IntiGIS methodology we will identify which is the most suitable autonomous generating system to cover the basic needs of the rural population in these Guatemalan communities. (Author) 9 refs.

  4. Alta miopia

    OpenAIRE

    Neves, Ana Raquel Borges

    2012-01-01

    O presente conjunto de apontamentos surge no âmbito de um estágio observacional realizado na Clínica Leite & Leite, em Lisboa, no decorrer do 2º ano do Mestrado em Optometria em Ciências da Visão. Neste relatório é relatada uma descrição do local onde se realizou o estágio, na qual constam todas as informações do percurso que qualquer paciente terá dentro da clínica em questão. De referir que, durante o tempo de estágio, foram observados 179 pacientes com diversas patologias, dados que pos...

  5. Plant densities of Urochloa decumbens in coexistence with Corymbia citriodoraDensidades de plantas de Urochloa decumbens em convivência com Corymbia citriodora

    Directory of Open Access Journals (Sweden)

    Jose Iran Cardoso Silva

    2011-12-01

    Full Text Available This study aimed to evaluate the effects of plant densities of Urochloa decumbens on the early growth of Corymbia citriodora. The experimental design was completely randomized design with four replications, each plot consisted of a of 60 L capacity vase. The signal grass densities were 0, 20, 40, 80 and 160 plants m-2, along with one eucalyptus plant. At the end of eight months of living together increase in height and in diameter and plant dry mass of eucalyptus and signal grass were carried out. The eucalyptus characteristics were influenced by all the weed populations, the effect being more pronounced with the increasing of grass density.O presente estudo teve como objetivo avaliar os efeitos da convivência de densidades crescentes de plantas Urochloa decumbens no crescimento inicial de plantas de Corymbia citriodora. O delineamento experimental adotado foi inteiramente casualisado, com quatro repetições; cada parcela constou de um vaso de 60 L de capacidade. As densidades de capim-braquiária foram: 0, 20, 40, 80 e 160 plantas m-2, juntamente com uma planta de eucalipto. Foram realizadas, ao final de oito meses de convivência, as avaliações de: incremento em altura e em diâmetro e massa seca das plantas de eucalipto e de capimbraquiária. Para todas as características estudadas a população infestante influenciou no desenvolvimento das plantas de eucalipto, sendo o efeito mais acentuado à medida que se aumentou a densidade de plantas de capim-braquiária.

  6. Estabilidad fenotípica y densidades de planta de genotipos de estevia (Stevia rebaudiana Bert. en la región Caribe de Colombia

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    Jarma Orozco Alfredo

    2011-06-01

    Full Text Available Los estudios de estabilidad fenotípica son importantes para la siembra de genotipos que muestranun adecuado comportamiento en una o varias zonas. Estevia (Stevia rebaudiana Bert. es una especierecientemente introducida en Colombia, por tanto, los estudios sobre su adaptación en áreas productorasdel país son escasos. Esta planta se caracteriza por sintetizar glucósidos de diterpeno altamenteedulcorantes con bajo aporte calórico. El presente estudio se realizó en Montería (8º 52' N y 76º 48'O, Colombia, con el objeto de determinar la estabilidad fenotípica de los genotipos Morita 1 y Morita 2de estevia, sembrados en tres densidades de plantas (25, 12.5 y 6.25 plantas/m2 y dispuestos en undiseño de bloques completos al azar, en tres épocas de siembra en el Caribe húmedo de Colombia. Losresultados más importantes señalan que Morita 2, en densidades de 25 plantas/m2, registró los mejoresíndices de estabilidad para el rendimiento de hoja seca/ha (Pig = 0; Pid = 0. Por su parte, éste mismogenotipo presentó una mayor relación hoja/tallo (1.17 ± 0.3 y mayor contenido de glucósidos totales(0.1586 ± 0.024 cuando la radiación solar fue mayor y las densidades eran entre 12.5 y 25 plantas/m2.

  7. Densidade e tamanho de formigueiros de Acromyrmex crassispinus em plantios de Pinus taeda Density and size of Acromyrmex crassispinus nests in Pinus taeda plantations

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    Mariane Aparecida Nickele

    2009-04-01

    Full Text Available O objetivo deste trabalho foi avaliar a densidade e o tamanho dos formigueiros de Acromyrmex crassispinus, ao longo do ano, em plantios de Pinus taeda de diferentes idades. Os experimentos foram realizados, em Rio Negrinho e em Três Barras, SC, em talhões de P. taeda com diferentes idades (recém-plantado, três anos e seis anos de idade. Em cada tratamento, foram demarcadas três parcelas de 1 ha. Os formigueiros foram classificados em três classes de tamanho: classe I, até 30 cm de diâmetro; classe II, 31 a 60 cm; e classe III, mais que 61 cm. A densidade de formigueiros de A. crassispinus foi menor no início do desenvolvimento da floresta, praticamente duplicou nos plantios com três anos, e reduziu quando a floresta estava com seis anos. A maior densidade de formigueiros ocorreu no período de dezembro a abril. Os formigueiros aumentaram de tamanho com a idade do pínus.The objective of this work was to evaluate the density and size of Acromyrmex crassispinus nests in Pinus taeda plantations along the year. The experiments were carried out in Rio Negrinho and Três Barras, SC, Brazil, in P. taeda plantations of different ages (recently planted and three and six years old. Three plots of one hectare were delimited in each treatment. The nests were classified according to three size classes: class I, up to 30 cm diameter; class II, 31 up to 60 cm; class III, above 61 cm. The density of A. crassispinus nests was low in recently planted areas, nearly twofold in three year-old plantations, and it reduced when the forest was six years old. The greatest nest density occurred in the period from December to April. The nests size increased along with the age of the P. taeda plantations.

  8. Estabilidad fenotípica y densidades de planta de genotipos de estevia (Stevia rebaudiana Bert. en la región Caribe de Colombia

    Directory of Open Access Journals (Sweden)

    Alfredo Jarma Orozco

    2011-04-01

    Full Text Available Los estudios de estabilidad fenotípica son importantes para la siembra de genotipos que muestran un adecuado comportamiento en una o varias zonas. Estevia (Stevia rebaudiana Bert. es una especie recientemente introducida en Colombia, por tanto, los estudios sobre su adaptación en áreas productoras del país son escasos. Esta planta se caracteriza por sintetizar glucósidos de diterpeno altamente edulcorantes con bajo aporte calórico. El presente estudio se realizó en Montería (8° 52' N y 76° 48' O, Colombia, con el objeto de determinar la estabilidad fenotípica de los genotipos Morita 1 y Morita 2 de estevia, sembrados en tres densidades de plantas (25, 12.5 y 6.25 plantas/m² y dispuestos en un diseño de bloques completos al azar, en tres épocas de siembra en el Caribe húmedo de Colombia. Los resultados más importantes señalan que Morita 2, en densidades de 25 plantas/m², registró los mejores índices de estabilidad para el rendimiento de hoja seca/ha (Pig = 0; Pid = 0. Por su parte, éste mismo genotipo presentó una mayor relación hoja/tallo (1.17 ± 0.3 y mayor contenido de glucósidos totales (0.1586 ± 0.024 cuando la radiación solar fue mayor y las densidades eran entre 12.5 y 25 plantas/m².

  9. Lipoproteínas de baja densidad y remanentes: diferentes mecanismos de oxidación y aterogénesis

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    Regina Wigdorovitz de Wikinski

    2010-12-01

    Full Text Available Las lipoproteínas de baja densidad oxidadas (LDLOX son factores cruciales en los mecanismos aterogénicos. Las LDL nativas y LDL pequeñas, densas, pasan al subendotelio por injuria endotelial, se oxidan en el subendotelio por efecto de radicales libres de oxígeno o disminución en la biodisponibilidad de óxido nítrico. Las LDLOX tienen propiedades quimiotácticas sobre los monocitos residentes, los cuales derivan de los monocitos circulantes que migraron al subendotelio con la cooperación de moléculas de adhesión. Las LDLOX se depositan en monocitos residentes/ macrófagos, formando células espumosas que evolucionan a estrías grasas y ateromas. En las lesiones no se encuentran LDL nativas, sino LDLOX que estimulan la esterificación del colesterol y son degradadas por macrófagos. Las lipoproteínas de muy baja densidad (VLDL y los quilomicrones son precursoras de las lipoproteínas de densidad intermedia (IDL y de los remanentes (QR, respectivamente. El conjunto de IDL y QR forma las lipoproteínas remanentes (RLP. Su papel aterogénico es atribuible a su oxidabilidad en plasma y en células endoteliales. Las RLP se oxidan en receptores específicos de las células endoteliales, que son dañadas por liberación de citoquinas, inflamación y apoptosis celular. En el subendotelio son captadas por células espumosas y se depositan en ateromas. Su efecto aterogénico está potenciado por los ácidos grasos libres, que dañan al endotelio.

  10. EFECTO DE LA DENSIDAD DE SIEMBRA Y DEL APORQUE EN LA PRODUCCIÓN Y CALIDAD DE LA CEBOLLA PUERRO (Allium ampeloprasum L. var. porrum J. Gay

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    Fernando Javier Peña Baracaldo

    2015-06-01

    Full Text Available La cebolla puerro y otras liliáceas, tradicionalmente, se han localizado en valles de climas medios y fríos moderados de las regiones andinas y cercanos a los centros de consumo. La producción y consumo de Allium ampeloprasum L. var. porrum J. Gay, se ha incrementado por sus cualidades condimentarias y por los beneficios de carácter medicinal. Los sistemas productivos implementados para esta hortaliza adoptan tecnologías procedentes de países con condiciones diferentes a las nuestras. Por lo tanto, para optimizar el cultivo y satisfacer la demanda creciente de mercados especializados, se requiere evaluar prácticas agronómicas, lo cual, se constituyó en el propósito del presente trabajo. Se determinó el efecto de cinco densidades de siembra y del aporque, sobre el peso, el diámetro y la longitud del tallo. Los resultados mostraron que a mayor densidad, el peso y el diámetro del fuste disminuyeron, sin ser afectadas por el aporque, mientras que la longitud de pseudotallo presentó una relación directamente proporcional: a mayor densidad, mayor longitud. Se obtuvieron puerros con longitudes superiores a la media del mercado, con las distancias de 20 x 25cm y 30 x 25cm, en donde también se lograron los mayores pesos frescos promedios, 354,93g y 354,42g, respectivamente. A una distancia de siembra de 30cm x 5cm, se cosecharon puerros largos y delgados. La práctica del aporque es necesaria dentro del sistema de producción de la cebolla puerro para el blanqueado del tallo; sin embargo, dicha práctica no influyó directamente sobre los parámetros de producción, como el peso y el diámetro del pseudotallo.

  11. GÉNEROS BACTERIANOS DOMINANTES EN LOS ESTRATOS FOLIARES DEL TABACO CURADO PARA CAPAS. INFLUENCIA DE LA NICOTINA Y EL pH SOBRE SU DENSIDAD POBLACIONAL

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    Yunior M. Morán Gómez

    2013-01-01

    Full Text Available Aunque las bacterias juegan un papel importante en el proceso fermentativo del tabaco, en Cuba no se han identificado los géneros presentes en el tabaco curado para capas, ni las variables que afectan a sus poblaciones. Este conocimiento pudiera contribuir al manejo de los procesos en los que estos microorganismos intervienen. El objetivo de esta investigación fue determinar la relación que existe entre la densidad poblacional de los géneros bacterianos dominantes en los diferentes estratos foliares de la planta de tabaco luego de la curación y la concentración de nicotina y los valores de pH en estos ambientes. Se realizó el aislamiento e identificación genérica de la microbiota bacteriana y se determinó el contenido de nicotina y el pH de las hojas de tabaco para cada estrato foliar. Las poblaciones de Bacillus en todos los estratos foliares siempre fueron superiores a otros géneros aislados como Staphylococcus y Arthrobacter . Desde los niveles foliares inferiores hasta los superiores el contenido de nicotina se incrementó significativamente, el pH mostró una ligera disminución (no significativa p<0,01 y disminuyó la densidad poblacional de bacterias de todos los géneros aislados. El modelo de regresión reveló que la disminución de la densidad poblacional de los géneros bacterianos que se aprecia al ascender por los diferentes niveles foliares estuvo más relacionada con el incremento de la concentración de nicotina en las hojas que con la variación del pH.

  12. Densidad mineral ósea y adecuación de la dieta en pacientes con enfermedad renal crónica en hemodiálisis

    OpenAIRE

    Fernando Carrasco; Marcelo Cano; Jean Camousseigt; Pamela Rojas; Jorge Inostroza; Rubén Torres

    2013-01-01

    Introducción: La desnutrición es común en la enfermedad renal crónica (ERC), junto a una menor masa muscular y densidad mineral ósea (DMO), aumentando el riesgo de morbilidad. Objetivo: Comparar la composición corporal (CC), DMO y el contenido mineral óseo (CMO) entre pacientes con ERC y sujetos sanos, relacionándolos con ingesta energética, de macro y micronutrientes. Métodos: Se evaluó CC en 30 pacientes en hemodiálisis y 28 voluntarios sanos con DEXA. Los pacientes llenaron tres registros ...

  13. Densidad poblacional de la codorniz Moctezuma (Cyrtonyx montezumae) en la región noroeste del Estado de México, México

    OpenAIRE

    Jaime Tapia Robles; Salvador Ibarra Zimbrón; Germán David Mendoza Martínez; Cecilia Zaragoza Hernández; Fernando Clemente Sánchez; Luis Antonio Tarango Arámbula

    2002-01-01

    El presente estudio se realizó para determinar la densidad poblacional de la codorniz Moctezuma ( Cyrtonyx montezumae) en la región noroeste del Estado de México, México. El área de estudio correspondió a la región cinegética II del calendario cinegético 1997, con un marco de muestreo de 249 700 ha, 73% forestal y 27% pastizales, mismos que fueron considerados como estratos. Se realizó un muestreo en 22 unidades, en las cuales se realizaron transectos de 5 km de longitud por 50 m ...

  14. Estudio de la adaptabilidad de cuatro genotipos de guisante (pisum setivum l. var. macrocarpon) bajo dos densidades y en dos localidades

    OpenAIRE

    Aguilar, Miguel; Brusco, Patricia; Martínez, Ricardo

    2011-01-01

    Se evaluó y comparó el comportamiento agronómico de cuatro variedades de guisante Pisum satim L. var. macrocarpon bajo dos densidades y en dos localidadesmediante cultivos a libre exposición durante dos semestres. Se midieron variables de tipo morfofisiológico y reproductivo. Las cuatro variedades se adaptaron bien al medio ambiente ya que sus rendimientos fueron bastante aceptables. La variedad Super Mel Sugar logró los mejores puntajesen rendimiento y calidad además de la mayor capacidad de...

  15. Fabricación y comportamiento de espumas de aluminio con diferente densidad a partir de un precursor AlSi12

    Directory of Open Access Journals (Sweden)

    Gutiérrez-Vázquez, J. A.

    2010-06-01

    Full Text Available Closed cell aluminium foams were prepared by powder metallurgical method in three different ranges of density using AlSi12 precursor. The objective has been to determine by means of tests the effect that has the density of these materials regarding its mechanical behaviour. The used precursor contained 0.4% of foaming agent of titanium hydride (TiH2, mixed with aluminum and silicon in appropriate amounts to achieve the commercial composition of the AlSi12 precursor. Once cut the samples thermal treatments of foaming were made of 630 °C to 750 °C, by 3 to 20 minutes. The best solidification conditions were determined to avoid the collapse by means of forced air. The samples were prepared with the same weight to different densities, having itself obtained that the best mechanical behaviour was achieved in the high density foams, of 0.70 to 0.81 g/cm3.

    Se han fabricado espumas de aluminio de poro cerrado, de tres diferentes rangos de densidad, utilizando un precursor AlSi12 producido por pulvimetalurgia. El objetivo ha sido determinar el efecto que tiene la densidad de estos materiales respecto a su comportamiento mecánico. El precursor utilizado contenía un 0,4 % de hidruro de titanio (TiH2 como agente espumante, mezclado con aluminio y silicio en cantidades adecuadas para lograr la composición comercial del precursor AlSi12. Una vez cortadas las muestras, se efectuaron tratamientos térmicos de espumación entre 630 y 750 °C, a tiempos de espumación variables entre 3 y 20 min. Se determinaron las mejores condiciones de solidificación para evitar el colapso mediante aire forzado. Las muestras se prepararon con el mismo peso a diferentes densidades, habiéndose obtenido, que el mejor comportamiento mecánico se lograba en las espumas de mayor densidad, comprendidas entre 0,70 y 0,81 g/cm3.

  16. DENSIDAD DE PALOMA DOMÉSTICA (Columbia livia domestica GMELIN, 1789) EN EL NUEVO MERCADO PÚBLICO DE SINCELEJO, SUCRE, COLOMBIA

    OpenAIRE

    Carmen Villalba-Sánchez; Alejandro De La Ossa-Lacayo; Jaime De La Ossa V

    2015-01-01

    El presente trabajo determinó la densidad poblacional de Columba livia domestica en el nuevo mercado de la ciudad de Sincelejo, Sucre, Colombia. Se conoce que cuando las poblaciones de esta especie se incrementan desmedidamente, se convierte en un serio problema de salud pública, que debe ser atendido, para evitar la transmisión de enfermedades zoonóticas. En Sincelejo, especialmente en la zona de estudio, se tenía desconocimiento de la magnitud de su población, al igual que sucede para mucha...

  17. Evolución del peso, densidad mineral ósea y metabolismo lipídico en el paciente trasplantado renal.

    OpenAIRE

    Fernández-Castillo, Rafael

    2015-01-01

    [ES]Tras el trasplante se producen una serie de alteraciones metabólicas que podrían llegar a poner en riesgo la supervivencia del injerto y comprometer seriamente el estado de salud del paciente trasplantado renal. Entre las complicaciones metabólicas mas importantes se encuentran las alteraciones del metabolismo mineral y óseo y las alteraciones del metabolismo lipídico. Este trabajo tiene como objetivo investigar la ganancia de peso, las modificaciones en la densidad mineral ósea y la hip...

  18. Larvicultura do Mandi-amarelo Pimelodus maculatus Lacépède, 1803 (Siluriformes: Pimelodidae) em Diferentes Densidades de Estocagem nos Primeiros Dias de Vida

    OpenAIRE

    Luz Ronald Kennedy; Zaniboni Filho Evoy

    2002-01-01

    Este trabalho foi realizado na Estação de Piscicultura de São Carlos (EPISCar), São Carlos, SC. O efeito da densidade de estocagem de Pimelodus maculatus na larvicultura foi avaliado em pós-larvas alimentadas diariamente com zooplâncton selvagem na proporção de 300 organismos/pós-larva/dia e submetidas aos seguintes tratamentos: T1 - 5 pós-larvas/litro; T2 - 15 pós-larvas/litro; T3 - 30 pós-larvas/litro. No terceiro e quinto dias de experimento, foi avaliada a taxa de sobrevivência. Decorrido...

  19. Património e turismo em áreas de baixas densidade : o caso das aldeias do Pessegueiro e do Esquio

    OpenAIRE

    Ventura, Marta Sofia Gomes

    2010-01-01

    Este trabalho apresenta uma reflexão sobre as trajectórias, dinâmicas e desenvolvimento das áreas rurais de montanha. A crescente valorização ambiental das áreas rurais trouxe novos dinamismos e potencialidades a estes espaços de baixas densidades. Outrora afectados por um intenso êxodo rural e por um paulatino e doloroso despovoamento e esquecimento, começam a ser redescobertos e a ganharem multifuncionalidades, vinculando-se a actividades lúdicas, desportivas ou terapêuticas. As áreas...

  20. Balance hídrico del suelo en pinares con diferente densidad de arbolado. Efectos sobre el establecimiento de brinzales de especies rebrotadoras bajo el dosel

    OpenAIRE

    Chirino Miranda, Esteban; Heredia-Osorio, Miriam; Granados, María Elena; Vilagrosa Carmona, Alberto; Manrique-Alba, Ángela; Ruiz-Yanetti, Samantha; Andarcio, Carlos; Bellot Abad, Juan Francisco

    2015-01-01

    El objetivo del presente trabajo fue determinar el balance hídrico del suelo en bosques de pino carrasco con diferente densidad de arbolado utilizando el modelo ecohidrológico HYDROBAL, y evaluar sus efectos sobre la introducción y establecimiento bajo el dosel, de brinzales de especies ampliamente utilizadas en la restauración forestal. En este contexto, en La Hunde (Ayora, Valencia), y como consecuencia de previas labores de aclareo con diferente intensidad, se definieron tres tratamientos ...

  1. Densidad ósea y frecuencias de hallazgos en restos humanos en el Norte de Tierra del Fuego: Análisis exploratorio

    OpenAIRE

    Suby, Jorge A.; Ricardo A. Guichón

    2004-01-01

    La disponibilidad del registro biológico humano para su estudio está condicionada por procesos paleoecológicos y tafonómicos. Vinculado con esta problemática interesa explorar la relación entre Densidad Mineral Ósea (DMO) y frecuencias relativas de restos óseos humanos en el norte de Tierra del Fuego. La determinación de DMO ha sido poco empleada para el estudio de restos óseos humanos arqueológicos. Se contrastó la información densitométrica de restos provenientes del sitio Las Mandíbulas (T...

  2. Densidade e tamanho de formigueiros de Acromyrmex crassispinus em plantios de Pinus taeda Density and size of Acromyrmex crassispinus nests in Pinus taeda plantations

    OpenAIRE

    Mariane Aparecida Nickele; Wilson Reis Filho; Edilson Batista Oliveira; Edson Tadeu Iede

    2009-01-01

    O objetivo deste trabalho foi avaliar a densidade e o tamanho dos formigueiros de Acromyrmex crassispinus, ao longo do ano, em plantios de Pinus taeda de diferentes idades. Os experimentos foram realizados, em Rio Negrinho e em Três Barras, SC, em talhões de P. taeda com diferentes idades (recém-plantado, três anos e seis anos de idade). Em cada tratamento, foram demarcadas três parcelas de 1 ha. Os formigueiros foram classificados em três classes de tamanho: classe I, até 30 cm de diâmetro; ...

  3. Evaluación forestal y de combustiblesen bosques de Pinus hartwegiien el Estado de México según densidades de cobertura y vulnerabilidad a incendios

    OpenAIRE

    Mario Fermin Castañeda Rojas; Angel Rolando Endara Agramont; María de Lourdes Villers Ruiz; Eufemio Gabino Nava Bernal

    2015-01-01

    En el presente estudio se hace una evaluación forestal asociada a la cantidad y calidad de combustibles muertos en bosques de P. hart-wegii para señalar condiciones de vulnerabilidad y propensión a incendios. Con interpretación de imágenes de satélite multiespectrales del 2010, se determinaron tres densidades de cobertura para 23 685 ha de bosque de P. hartwegii del Estado de México. Se realizó un inventario forestal, presencia de actividad humana, carga de combustibles y parámetros físicos e...

  4. LA DENSIDAD Y TAMAÑO DE PLÁNTULAS CON CEPELLÓN EN LA PRODUCCIÓN DE ESPÁRRAGO VERDE

    Directory of Open Access Journals (Sweden)

    Ana Mar\\u00EDa Castagnino

    2011-01-01

    Full Text Available Con el objetivo de determinar la influencia del tamaño de la celda utilizada para la obtención de plántulas de espárrago y la densidad o marco de plantación empleado, sobre la producción de turiones, se evaluó en invernadero tres tamaños de celda: 1 PG: grande (70 cm3, 2 PM: mediana (30 cm3 y 3 PCh: pequeña (20 cm3 y tres densidades (35 714 (D1; 23 810 (D2 y 17 857 (D3 plantas/ha. Se efectuó un trabajo en la Chacra Experimental de la Facultad de Agronomía, en Azul, provincia de Buenos Aires. La plantación en el campo se efectuó en noviembre 2002, setenta días después de la siembra del almácigo con plántulas con cepellón. La cosecha se realizó del 25/09 al 18/10 del año 2006, en el cuarto año desde la plantación, con una frecuencia de cosecha de día por medio. Se realizó un análisis de la varianza, con un diseño completamente al azar y considerando como factor: el tamaño de las plántulas que provenían de cada contenedor y tres densidades. En el segundo año evaluado, la densidad D1 fue la de mayor producción (4450 kg/ha netos totales y mayor cantidad de turiones (380 166. Las plantas provenientes de los dos mayores tamaños de celda produjeron 4 t/ha netas en promedio. Las bandejas de siembra de tamaño G y D1 resultaron más apropiados para la producción de espárrago ya que permitieron obtener el mayor rendimiento en peso y número, y obtener un mejor aparato radical.

  5. Densidade e diversidade fenotípica de bactérias diazotróficas endofíticas em solos de mineração de bauxita, em reabilitação Density and phenotypic diversity of endophytic nitrogen fixing bacteria in soils under rehabilitation after bauxite mining

    Directory of Open Access Journals (Sweden)

    R. Melloni

    2004-02-01

    Full Text Available Bactérias diazotróficas endofíticas contribuem para o desenvolvimento das plantas por meio da fixação biológica do nitrogênio, produção e liberação de substâncias reguladoras do crescimento vegetal, podendo, assim, facilitar a revegetação de solos degradados por atividades antrópicas. No entanto, pouco se conhece sobre as populações destas bactérias em solos ou plantas de áreas de mineração. Objetivando avaliar o efeito de diferentes tipos de vegetação e tempo de reabilitação de áreas degradadas por mineração de bauxita na densidade e diversidade de algumas espécies de bactérias diazotróficas endofíticas, realizaram-se, em duas épocas, amostragens de solo, de dois ambientes distintos, submetidos a diferentes processos de reabilitação. A densidade, avaliada pelo número mais provável, utilizando os meios de cultura: NFb, JNFb e Fam, para Azospirillum brasilense e A. lipoferum, Herbaspirillum spp. e A. amazonense, respectivamente, variou de 0 a 2,0 x 10(4 bactérias por grama de solo e mostrou que o tipo de vegetação influiu nas populações destas bactérias. Foram encontradas densidades maiores em solos revegetados com gramíneas: braquiária (Brachiaria decumbens, capim-azevém (Lolium multiflorum e capim-gordura (Melinis minutiflora. Contudo, estas densidades podem ser consideradas baixas, se comparadas às de solos agrícolas, e não apresentaram relação com o tempo de reabilitação da área. Foram encontrados 36 fenótipos culturais em meio batata, entre os 72 isolados obtidos dos três meios de cultura utilizados. A partir destes, foram formados sete grandes grupos com similaridade superior ou igual a 63 %, dos quais cinco, representando 62,5 % do total de isolados obtidos, continham as estirpes-tipo de Burkholderia brasilensis, Herbaspirillum seropedicae e Azospirillum spp. (A. brasilense, A. amazonense, A. lipoferum, A. irakense. Apesar da baixa densidade, este grupo de bactérias apresentou alta

  6. Lipoprotein Lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS

    Directory of Open Access Journals (Sweden)

    Tiwari Hemant K

    2011-08-01

    Full Text Available Abstract Background Previous analysis clustered 1,238 individuals from the general population Genetics of Lipid Lowering Drugs Network (GOLDN study by the size of their fasting very low-density, low-density and high-density lipoproteins (VLDL, LDL, HDL using latent class analysis. From two of the eight identified groups (N = 251, ~75% of individuals met Adult Treatment Panel III criteria for the metabolic syndrome (MetS. Both showed small LDL diameter (mean = 19.9 nm; however, group 1 (N = 200 had medium VLDL diameter (mean = 53.1 nm while group 2 had very large VLDL diameter (mean = 65.74 nm. Group 2 additionally showed significantly more insulin resistance (IR, and accompanying higher waist circumference and fasting glucose and triglycerides (all P LPL gene variants: D9N (rs1801177 and S447X (rs328. Findings Mixed linear models that controlled for age, sex, center of data collection, and family pedigree revealed no differences between the two groups for the D9N polymorphism (P = .36. However, group 2 contained significantly more carriers (25% of the 447X variant than group 1 (14%; P = .04. Conclusions This was the first study this kind to show an association between LPL and large VLDL particle size within the MetS, a pattern associated with higher IR. Future work should extend this to larger samples to confirm these findings, and examine the long term outcomes of those with this lipoprotein diameter pattern.

  7. Synbiotic food consumption reduces levels of triacylglycerols and VLDL, but not cholesterol, LDL, or HDL in plasma from pregnant women.

    Science.gov (United States)

    Taghizadeh, Mohsen; Hashemi, Teibeh; Shakeri, Hossein; Abedi, Fatemeh; Sabihi, Sima-Sadat; Alizadeh, Sabihe-Alsadat; Asemi, Zatolla

    2014-02-01

    To our knowledge, no reports are available indicating the effects of synbiotic food consumption on blood lipid profiles and biomarkers of oxidative stress among pregnant women. This study was conducted to evaluate the effects of daily consumption of a synbiotic food on blood lipid profiles and biomarkers of oxidative stress in pregnant women. This randomized, double-blind, controlled clinical trial was performed among 52 primigravida pregnant women, aged 18 to 35-year-old at their third trimester. After a 2-week run-in period, subjects were randomly assigned to consume either a synbiotic (n = 26) or control food (n = 26) for 9 weeks. The synbiotic food consisted of a probiotic viable and heat-resistant Lactobacillus sporogenes (1 × 10⁷ CFU) and 0.04 g inulin (HPX)/g as the prebiotic. Patients were asked to consume the synbiotic and control foods two times a day. Biochemical measurements including blood lipid profiles, plasma total antioxidant capacity (TAC) and total glutathione (GSH) were conducted before and after 9 weeks of intervention. Consumption of a synbiotic food for 9 weeks resulted in a significant reduction in serum TAG (P = 0.04), VLDL (P = 0.04) and a significant rise in plasma GSH levels (P = 0.004) compared to the control food. No significant effects of the synbiotic food consumption on serum TC, LDL, HDL and plasma TAC levels (P > 0.05) were observed. Trial registry code: http://www.irct.ir . IRCT201212105623N3. PMID:24271261

  8. Efeitos do treinamento resistido na lipoproteína de baixa densidade Effects of resistance training on low density lipoprotein

    Directory of Open Access Journals (Sweden)

    Jeferson Luis da Silva

    2010-02-01

    Full Text Available Os benefícios da prática regular do exercício físico estão claramente estabelecidos na literatura. Entretanto, a escolha do tipo de exercício ideal pode ser mais salutar para indivíduos com doenças específicas e patologias associadas. O propósito desta revisão foi verificar se o treinamento resistido (TR exerce alguma alteração no colesterol da lipoproteína de baixa densidade (LDL-C. Foram observadas grandes diferenças na literatura, dificultando uma conclusão em relação aos benefícios do TR nesta revisão. No entanto, foi visto que o TR pode ser promissor na redução dos níveis de LDL-C, principalmente em homens e mulheres adultos, em pacientes com diabetes mellitus tipo 1 e tipo 2 e em mulheres pré-menopausa, não mostrando diferenças na população idosa. Os autores concluem que o TR é uma boa opção de exercício físico para indivíduos, principalmente quando o treinamento aeróbio (TA é contraindicado.The benefits of exercise regular practice are clearly established in the literature. However, the choice of the ideal exercise may be more beneficial for individuals with specific diseases and associated pathologies. The aim of this review was to determine whether resistance training (RT promotes any change on low density lipoprotein cholesterol. Important differences were observed in research protocols, making it difficult to define the benefits of RT in this review. However, it was noticed that RT may be promising in reducing LDL-C levels mainly in adult men and women, in patients with diabetes mellitus type 1 and type 2 and in pre-menopausal women, not presenting differences in the elderly population. It was concluded that the RT is an option good of physical exercise for individuals, especially when the aerobic training (AT is contra-indicated.

  9. Densidade mineral óssea de adolescentes com sobrepeso e obesidade Bone mineral density in overweight and obese adolescents

    Directory of Open Access Journals (Sweden)

    Fernanda Cobayashi

    2005-08-01

    Full Text Available OBJETIVO: Estudar a densidade óssea como fator concomitante da obesidade em adolescentes pós-púberes, controlando outras variáveis que possam interferir nessa relação. MÉTODOS: Estudo com 83 sobrepesos e obesos (IMC > P85 e 89 não obesos (P5 OBJECTIVE: to study bone density as a concomitant factor for obesity in post-pubertal adolescents, controlling for other variables that may interfere in such a relation. METHODS: Study comprising 83 overweight and obese adolescents (BMI > P85 and 89 non obese ones (P5 < BMI < P85. Cases and controls were selected out of 1,420 students (aged 14-19 from a public school in the city of São Paulo. The bone mineral density of the lumbar spine (L2-L4 in g/cm² was assessed by dual-energy x-ray absorptiometry (LUNAR™ DPX-L. The variable bone density was dichotomized using 1.194 g/cm² as cutoff point. Bivariate analyses were conducted considering the prevalence of overweight and obesity followed by multivariate analysis (logistic regression according to a hierarchical conceptual model. RESULTS: The prevalence of bone density above the median was twice more frequent among cases (69.3% than among controls (32.1%. In the bivariate analysis such prevalence resulted in an odds ratio (OR of 4.78. The logistic regression model showed that the association between obesity and mineral density is yet more intense with an OR of 6.65 after the control of variables related to sedentary lifestyle and intake of milk and dairy products. CONCLUSION: Obese and overweight adolescents in the final stages of sexual maturity presented higher bone mineral density in relation to their normal-weight counterparts; however, cohort studies will be necessary to evaluate the influence of such characteristic on bone resistance in adulthood and, consequently, on the incidence of osteopenia and osteoporosis at older ages.

  10. Densidad de población de pequeños mamíferos en dos comunidades del bosque Andino Densidad de población de pequeños mamíferos en dos comunidades del bosque Andino

    Directory of Open Access Journals (Sweden)

    Rodríguez Jane Rose

    1988-06-01

    Full Text Available

    The density of small mammals living in two communities of the Andean Forest of the eastern slopes of the Sabana de Bogota in the western Cordillera (Cerro Cueva Grande and Cerro Majuy, was studied. The two places were tramped for six months between March and September 1981, using livetraps and snaptraps during six days per month in each community. Densities for each species were obtained by the Hayne Melbod, the Lincoin and Jolly Indexes and by absolute density. Flora, climate and soil characteristics and their influence in the species were also considered in the two communities.

    Se estudió la densidad de población de pequeños mamíferos en dos comunidades de Bosque Andino, Cerro Cueva Grande, en el flanco occidental de la Sabana de Bogotá y Cerro Majuy, en la Sabana, localizadas sobre la Cordillera Oriental. Los dos sitios fueron trampeados en un periodo de seis meses desde marzo hasta septiembre del año 1981, uti1izando trampas para captura de animales vivos y trampas de golpe durante seis días por mes en cada comunidad. Se obtuvieron densidades para cada especie por el método de Hayne, y los índices de Lincoln, de Jolly y de densidad absoluta. Se tuvieron en cuenta las características de flora, clima y suelo para las dos comunidades y la manera como influye en las especies estudiadas.

  11. El ferulado con caños de polietileno de baja densidad PBDE para agua en la reparación de las fracturas acrales

    OpenAIRE

    Baraboglia, E. R.

    2010-01-01

    ResumenDesde el principio de los tiempos se le ha presentado al hombre el problema de las fracturas traumáticas y es de imaginar que tal vez en tan o más alta proporción que ahora, dado el sistema rudo en que les tocaba vivir.

  12. Plan de alta para personas con enfermedad pulmonar obstructiva crónica

    Directory of Open Access Journals (Sweden)

    Luz Marina Céspedes Salgado

    2006-01-01

    Full Text Available El plan de alta busca asegurar unos cuidados acordes con las necesidades y los requerimientos de la persona una vez egresa de la institución de salud, y debe constituirse en una guía básica en especial para la atención de aquéllos con patologías crónicas, como es la enfermedad pulmonar obstructiva crónica, que por su complejidad demanda múltiples cuidados para asegurar una intervención integral con miras al logro de una mejor adaptación, a identificar posibles complicaciones y a mejorar su calidad de vida. La experiencia de haber asumido el rol de hija y enfermera de un padre con enfermedad pulmonar obstructiva crónica (EPOC, y la alta incidencia de esta enfermedad, motivaron la elaboración de este plan de alta; fueron muchos los cuidados y muchas las necesidades y los cuestionamientos que se daban día a día, desde asegurar una adecuada comunicación hasta un conocimiento de los signos y síntomas de urgencia que indicaban una exacerbación, del uso adecuado de los medicamentos, de la importancia de la oxigenoterapia a largo plazo, de proporcionarle una dieta acorde con las recomendaciones y un ambiente favorable para sus condiciones de salud para, en últimas, alcanzar un entorno armónico, físico, familiar y espiritual.

  13. Recubrimientos depositados por cvd-fbr para protección a alta temperatura

    OpenAIRE

    Jose Luddey Marulanda-Arevalo; Saul Castañeda-Quintana; Aduljay Remolina-Millan

    2013-01-01

    La deposición química de vapor por lecho fl uidizado (CVD-FBR) es una variante de la técnica de deposición química de vapor; que combina las ventajas de la activación térmica por calentamiento y el lecho fl uidizado. Los recubrimientos mediante CVD-FBR son ampliamente investigados y usados debido a la necesidad de proteger superfi cialmente los componentes que operan a altas temperaturas, el cual ha aumentado perceptiblemente. Además, tiene la ventaja de ser una técnica de bajo costo, puede c...

  14. Anticorpos policlonais em dietas com alta inclusão de concentrado para bovinos confinados

    OpenAIRE

    Danilo Domingues Millen; João Ricardo Ronchesel; Fernando Salvador Parra; Rodrigo Dias Lauritano Pacheco; Cyntia Ludovico Martins; Mário de Beni Arrigoni

    2013-01-01

    Dentre as alternativas para substituir o uso de ionóforos classificados como antibiótico por alguns comitês, a utilização de anticorpos policlonais classificados como promotores de crescimento naturais tem se mostrado alternativa interessante e economicamente eficiente. Recentes estudos demonstraram pontos positivos na utilização desse aditivo em dietas com alta inclusão de ingredientes concentrados para bovinos confinados, traduzido por melhora de desempenho e saúde ruminal, em alguns casos,...

  15. Contabilidad Financiera y Social de la Alta Velocidad en España

    OpenAIRE

    Ofelia Betancor; Gerard Llobet

    2015-01-01

    Este trabajo estudia la rentabilidad financiera y social de la alta velocidad ferroviaria en España. El análisis se realiza para los cuatro corredores en funcionamiento a finales de 2013. Ambos análisis son contrafactuales, es decir, toman como punto de referencia lo que habría sucedido en caso de no acometer estas inversiones. Asimismo ambos se realizan para un horizonte temporal de 50 años que nos lleva a utilizar como criterios de decisión el VAN financiero y social en términos de valor es...

  16. El entrenamiento interválico de alta intensidad para el rendimiento deportivo

    OpenAIRE

    Alvarez Fernández, Iker

    2014-01-01

    El entrenamiento interválico de alta intensidad (HIIT) ha sido una parte más de los programas de entrenamiento para mejorar el rendimiento deportivo, pero su efecto puntual en los entrenamientos de deportistas altamente entrenados no se conoce en su totalidad, a pesar de ser un elemento importante de la preparación deportiva. En esta revisión veremos cómo diversas investigaciones demuestran los diferentes efectos y adaptaciones que provoca el HIIT en estos deportistas con el fin de la mejora ...

  17. USO DE IMÁGENES SATELITALES DE ALTA RESOLUCIÓN PARA GENERAR CARTOGRAFÍA

    OpenAIRE

    Patricio Zavala; Carlos Zavala

    2002-01-01

    Se presenta la metodología aplicada en la ciudad de Arica, Norte de Chile, para generar cartografía de altura de construcciones, mediante el análisis digital de una imagen satelital de alta resolución. Para ello, nos basamos en el cálculo de la longitud de las sombras que se derivan de distintas edificaciones, y del azimut solar de una imagen IRS 1C, que fue remuestreada mediante convolución cúbica a 5 metros. Este trabajo está basado fundamentalmente en los logros alcanzados en el desarrollo...

  18. Ampliación de un generador de impulsos de alta tensión

    OpenAIRE

    Hernández Anguita, Iker

    2011-01-01

    El primer objetivo de este proyecto fin de carrera será hallar el valor de la capacidad del objeto de ensayo, en este caso un transformador de corriente de alta tensión con el bobinado secundario cortocircuitado a tierra. Se realizara la medición por distintos métodos para contrastar los resultados. Este valor de capacidad será necesario para el dimensionado de las resistencias de descarga del generador. Una vez obtenido el valor de la capacidad se procederá a la construcción de los nuevos el...

  19. La identificación de alumnos con altas habilidades: enfoques y dimensiones actuales

    OpenAIRE

    Rojo Martínez, Angela

    1996-01-01

    La tesis ha quedado estructurada en dos partes. En la primera, se desarrolla y fundamenta el marco teórico de este trabajo de investigación, desde el que se presentan los principales planteamientos conceptuales que han ayudado y están contribuyendo a definir la alta habilidad intelectual, haciendo especial hincapié en enfoques amplios y variados, que permitan que la identificación de esos sujetos se realice considerando junto a su potencial intelectual otras muchas y diferentes variables. Y l...

  20. CARCINOMA BRONQUÍOLO-ALVEOLAR: ASPECTOS NA TOMOGRAFIA COMPUTADORIZADA DE ALTA RESOLUÇÃO

    OpenAIRE

    Moreira Luiza Beatriz Melo; Marchiori Edson; Melo Alessandro Severo Alves de; Magnago Marcelo; Muniz Maria Angélica Soares; Irion Klaus

    2002-01-01

    O carcinoma bronquíolo-alveolar é um tipo de carcinoma broncogênico de crescimento insidioso, que surge nas paredes das vias aéreas distais e se dissemina utilizando o septo alveolar como um estroma, preservando a arquitetura pulmonar. Neste trabalho foram analisadas as tomografias computadorizadas de alta resolução de 17 pacientes com carcinoma bronquíolo-alveolar. Ao contrário do relatado na literatura, foram observados predomínio no sexo masculino (71%) e maior freqüência da associação das...