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Sample records for alta densidad hdl

  1. TOTAL CHOLESTEROL, HIGH DENSITY LIPOPROTEINS (HDL AND CORTISOL PLASMA LEVELS, AND THEIR BIORHYTMICITY, IN 24 HOURS, THROUGHOUT YEAR, IN IDEAL-POLWARTH RAMS NÍVEIS PLASMÁTICOS DE COLESTEROL TOTAL, LIPOPROTEÍNAS DE ALTA DENSIDADE (HDL E CORTISOL, E SUA BIORRITMICIDADE, EM CARNEIROS IDEAL-POLWARTH

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    Alcides de Amorim Ramos

    2006-12-01

    Full Text Available To evaluate the mean plasma concentrations of total cholesterol (TC, high density lipoproteins (HDL and cortisol, blood samples were collected of five Ideal-Polwarth rams, maintained at 22?53’S latitude, in semi-confinement, every two months throughout the year, by 24h period, with 2-hour intervals between colects. The TC, changed 40.70?1,11mg/dL (April and 61.48?1,11mg/dL (December, between months, while HDL changed 22.16?0.23mg/dL (December as 33.40?0.23mg/dL (February, but not make evident a circannual rhythm in this levels. The TC presented the lowest value at 16:30h (50.40?1.57mg/dL and the highest value at 8:30h collect (54.67?1.57mg/dL; the HDL lowest level was at 10:30h (27.04?0.33mg/dL and the highest level also at 8:30h collect (28.49?0.33mg/dL, however without permit circadian rhythm determination in your plasma concentrations. Similarly, the cortisol plasma concentrations, between collect months, presents variable, however without demonstrate circadian rhythm in this hormone secretion. In relation to different collection’s moments, throughout months, it wasn’t possible to define, by statistical analysis, a circadian rhythm of cortisol secretion. KEY WORDS: Ovine, adrenal hormone, biochemistry metabolites, circadian rhythm. Visando avaliar as concentrações médias de colesterol total (CT, lipoproteínas de alta densidade (HDL e cortisol plasmáticos, foram colhidas amostras de sangue de cinco carneiros Ideal-Polwarth, alocados em latitude 22°53’S, em regime de semiconfinamento, a cada dois meses, ao longo de um ano, com as colheitas em um período de 24 horas, e intervalos de duas horas entre elas. O CT oscilou entre 40,70±1,11mg/dL (abril e 61,48±1,11mg/dL (dezembro, entre os meses, enquanto HDL variou de 22,16±0,23mg/dL (dezembro a 33,40±0,23mg/dL (fevereiro, mas não evidenciando um ritmo circanual em seus níveis. O CT apresentou seu valor mínimo na colheita das 16h30min (50,40±1,57mg/dL e o máximo às 8h30min

  2. Sistemas de producción de fresa de altas densidades.

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    Ramírez Gómez, Humberto

    2011-01-01

    En México se produce fresa con alta tecnología pero existe escasa investigación sobre la productividad de la fresa en sistemas hidropónicos con altas densidades. El presente estudio se realizó con la finalidad de evaluar la fisiología, rendimiento, calidad y rentabilidad de la fresa de altas densidades en cuatro sistemas hidropónicos. Los tratamientos estudiados fueron: bolsas individuales (BI), vertical con tres tubos (V3T), vertical con cuatro tubos (V4T) y vertical con macetas hidropónicas...

  3. Waist circumference is better associated with high density lipoprotein (HDL-c than with body mass index (BMI in adults with metabolic syndrome Circunferencia de la cintura es mejor asociado con lipoproteínas de alta densidad (LAD-C que con el índice de masa corporal (IMC en adultos con síndrome metabólico

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    S. T. Arimura

    2011-12-01

    Full Text Available Background: The measurement of waist circumference (WC is the most prevalent cause of the metabolic syndrome (MS. Objective: The aim of this study was to correlate WC and BMI with high-density lipoprotein (HDL-c levels in patients with MS being consulted by the Family Health Program (PSF, Brazil. Methods: This cross-sectional study was conducted from September to November 2008 with 42 patients (29 women and 13 men from 35 to 77 years. Dietary intake was reported, and biochemical and body composition measures were taken. Results: The HDL-c levels were higher in women when compared to men (48.4 ± 8.1 mg/dL vs. 36.4 ± 7.8 mg/dL. However, the triglycerides (TG/HDL-c ratio and TG concentrations were lower in women (3.8 ± 1.5 and 178.0 ± 57.8 mg/dL, respectively than in men (9.4 ± 8.5 and 471.5 ± 501.5 mg/dL, respectively. Regarding skinfold profile, the triceps was greater in females (37.0 ± 8.4 cm vs. 20.7 ± 10.5 cm. The dietetic profile showed that women had a lower intake of energy, fiber, phosphorus and sodium. The fruits and vegetables intake was diminished in the participants of this study, as less than 60% of the women and 50% of men met the daily recommendations. Approximately 54% of men and 28% of women had a lower intake of dairy products daily. Moreover, the results shows that the WC was negatively correlated to HDL-c (r = -0.41, p 0.06. Conclusion: Our findings showed that WC is a better predictor of changes in HDL-c than BMI.Antecedentes: La medición de la circunferencia de la cintura (CC es la causa más prevalente del síndrome metabólico (SM. Objetivo: el propósito de este estudio fue correlacionar la CC y el IMC con las concentraciones de lipoproteínas de densidad elevada (HDL-c en pacientes con SM vistos en consulta del Programa de salud familiar (PSF, de Brasil. Métodos: Este estudio trasversal se realizó entre septiembre y noviembre de 2008 en 42 pacientes (29 mujeres y 13 hombres de 35 a 77 años. Se registró la

  4. Cultivo de cachama blanca en altas densidades y en dos sistemas cerrados

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    Germán Poleo

    2011-04-01

    Full Text Available El objetivo de este trabajo fue evaluar la tolerancia de la cachama blanca, Piaractus brachypomus, a cultivos en altas densidades en sistemas cerrados. Novecientos alevines de 44,3±26 g de peso, se distribuyeron en seis tanques de concreto, con 4,8 m³ de agua. Tres tanques presentaron cero recambio de agua (SCR, y en otros tres, el agua se hizo circular a través de un bioclarificador (SRA. Ambos tratamientos presentaron fuerte aireación para mantener los sólidos en suspensión y suministrar aire. Los peces se alimentaron a saciedad con pienso comercial por 192 días. Los parámetros de calidad de agua como: oxígeno disuelto, amonio total, nitritos, nitratos, alcalinidad, dureza, temperatura y pH, se midieron semanalmente. Los peces en el SCR crecieron a una tasa de 2,34±0,05 g por día, y tuvieron conversión alimenticia de 1,5±0,06, densidad final de 12,96±0,53 kg m-3, y peso final de 449,5±99 g. En el SRA, los peces crecieron 2,33±0,03 g por día, con conversión alimenticia de 1,6±0,07, densidad final de 12,13±1,12 kg m-3, y peso final de 446,5±10 g. La cachama blanca puede ser cultivada en sistemas cerrados con cero recambio de agua en altas densidades.

  5. Cultivo de cachama blanca en altas densidades y en dos sistemas cerrados

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    Germán Poleo; José Vicente Aranbarrio; Lismen Mendoza; Oneida Romero

    2011-01-01

    El objetivo de este trabajo fue evaluar la tolerancia de la cachama blanca, Piaractus brachypomus, a cultivos en altas densidades en sistemas cerrados. Novecientos alevines de 44,3±26 g de peso, se distribuyeron en seis tanques de concreto, con 4,8 m³ de agua. Tres tanques presentaron cero recambio de agua (SCR), y en otros tres, el agua se hizo circular a través de un bioclarificador (SRA). Ambos tratamientos presentaron fuerte aireación para mantener los sólidos en suspensión y suministrar ...

  6. Morfología y propiedades de politereftalato de etilen-glicol y polietileno de alta densidad

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    Guerrero, Carlos; Lozano, Tomás; González, Virgilio; Arroyo, Eliud

    2003-01-01

    Se estudiaron mezclas de politereftalato de etilen- glicol, PET y polietileno de alta densidad, HDPE, con y sin agente compatibilizante. Ambos materiales se usan ampliamente en la industria de bebidas carbonatadas. El agente compatibilizante que se usó fue un copolímero de etileno y ácido metacrílico parcialmente neutralizado con zinc (Surlyn). Como hipótesis se planteó que el segmento olefínico del Surlyn podría ser compatible con el HDPE, mientras que los grupos c...

  7. TSH Normal Alta: Su relación con bajo HDL-Colesterol en mujeres con resistencia a la insulina con independencia de otros posibles factores concurrentes

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    J Rezzónico

    2008-12-01

    Full Text Available Objetivo: En el hipotiroidismo tanto clínico como subclínico se han descripto alteraciones en el metabolismo lipídico, entre ellas la disminución de colesterol de lipoproteínas de alta densidad (HDL-C. Considerando el rango normal de TSH entre 0.4-3.0 μUI/ml y valores normales altos entre 2.0 y 3.0 μUI/ml, nosotros investigamos la hipótesis de que niveles normales altos de TSH e insulinorresistencia (IR se encuentran relacionados con HDL-C bajo en mujeres, en ausencia de otros factores concurrentes. Materiales y métodos: Estudiamos en un estudio transversal a 200 mujeres sanas, edad 18-50 años, eutiroideas, normotensas, con anticuerpos antiperoxidasa (ATPO negativos, no diabéticas, premenopáusicas, IMC 18.0-25.0 Kg/m2, perímetro de cintura ≤ 88 cm; perímetro de cuello ≤ a 35 cm. Se las dividió en 4 grupos, cada uno compuesto por 50 mujeres: Grupo 1 (G1 TSH ≥ 2μU/ml, IR; grupo 2 (G2 TSH ≥ 2μU/ml, no IR; grupo 3 (G3: TSH 0,40 a 1,99 μU/ml, IR; Grupo 4 (G4 TSH 0,40 a 1,99 μU/ml, no IR. Se les midió lípidos, TSH, T4 total y libre (T4L, glucosa e insulina basal y posprandial, índices HOMA y QUICKI y volumen tiroideo (VT. Resultados: Observamos que en el G1 el nivel de HDL-C (46,7± 8,1 mg/dl fue significativamente menor que en los restantes grupos. (vs G2: 56,8 ± 8,6 mg/dl; vs G3: 51,2 ± 7,6 mg/dl y vs G4: 56,5 ± 9,1 mg/dl. (pIt has been described abnormalities in lipid metabolism in clinical and subclinical hypothyroidism, including the reduction of high-density lipoprotein cholesterol (HDL-C. Considering the normal range for TSH between 0.4-3.0 uUI / ml and high-normal values between 2.0 and 3.0 uUI / ml, we investigated the hypothesis that in euthyroid women, high-normal TSH levels and insulin resistance (IR are associated with low HDL-C. We observed in euthyroid women with high-normal TSH and insulin resistance, without other factors, a significantly lower level of HDL-C than in non-insulin or insulin resistance

  8. Síntesis y caracterización de un material compuesto a base de polietileno de alta densidad y magnetita pulverizada

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    Garzón Posada, Andrés Orlando

    2015-01-01

    En este trabajo se pretende producir un material compuesto a base de polietileno de alta densidad (HDPE) y magnetita pulverizada (Fe3O4) con el fin de caracterizar sus propiedades mecánicas, magnéticas y eléctricas. Este tipo de matrices poliméricas reforzadas con magnetita han sido motivo de estudio en los recientes años con el fin de desarrollar materiales con aplicaciones tecnológicas enfocadas a la ingeniería y a la biomedicina. Para optimizar el enfoque y el uso tanto de este material co...

  9. Cinética de cristalização não-isotérmica de resíduos de polietileno de alta densidade (PEAD)

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    Helson Moreira da Costa; Mônica Calixto de Andrade; Milena Diniz Lessa; Valéria Dutra Ramos

    2014-01-01

    Nesta investigação, diversos resíduos incolores ou coloridos pós-consumo de polietileno de alta densidade (PEAD) foram caracterizados através do índice de fluidez (MFI) e da calorimetria exploratória diferencial (DSC). A equação de Avrami modificada por Jeziorny, e os modelos de Kissenger e Friedman foram utilizados para descrever a cinética de cristalização não-isotérmica das amostras. Foi verificado que os pigmentos presentes no PEAD têm diferentes habilidades nucleantes durante o processo ...

  10. Densidad de ungulados en bosques de baja y alta presión de caza en el nororiente de la Amazonía peruana

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    Rolando Aquino

    2015-01-01

    Full Text Available Se proporciona información sobre tamaño de rebaño en pecaríes y densidad poblacional de éstos y otros ungulados para los bosques de baja y alta presión de caza del nororiente peruano. Durante el recorrido de 610 km de transecto de Noviembre-Diciembre 2012 en bosques de baja presión de caza y de 1218 km desde Febrero-Junio y Agosto-Octubre 2013 en bosques de alta presión de caza, fueron registrados 76 y 40 encuentros pertenecientes a seis y cinco especies, respectivamente; siendo los más comunes Pecari tajacu (35% y Mazama americana  (28%. El tamaño de rebaño en P. tajacu varió desde 2 a 8 individuos (tamaño promedio: 3,4±1,6 a 6±1,2. La densidad poblacional estimada para los ungulados fueron más altas en bosques de baja presión de caza sobresaliendo Tayassu pecari con 23,8 individuos/km2, seguido por P. tajacu con 14,4 individuos/km2, en tanto que la más baja fue para Tapirus terrestris (0,08 individuos/km2 y correspondió a los bosques de alta presión de caza. En los bosques de baja presión de caza, los encuentros más frecuentes con ungulados ocurrieron en el palmal de altura (46% y palmal de planicie (31%, en tanto que en el pantano arbóreo no hubo encuentros.

  11. Nanocompósitos poliméricos de polietileno de alta densidade contendo hidróxidos duplos lamelares intercalados com ânions derivados de corantes azo

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    Ademir Zimmermann

    2014-06-01

    Full Text Available O presente trabalho descreve a síntese e caracterização de hidróxidos duplos lamelares (HDL de Zn/Al na razão molar 2:1, os quais foram intercalados com íons cloreto hidratados e ânions derivados dos corantes azo alaranjado de metila (AM e alaranjado II (AII. Após caracterização, os materiais foram utilizados como cargas em polietileno de alta densidade (PEAD e nanocompósitos foram preparados por extrusão e injeção, seguindo a norma ASTM D638-10. Os teores de cargas variaram de 0,1 até 2% (incluindo-se os sais de sódio dos corantes e os nanocompósitos homogêneos foram avaliados em relação as suas propriedades estruturais, térmicas e mecânicas. De modo geral, após a adição das cargas existe somente uma pequena influência na temperatura de fusão e cristalização do PEAD. Para os HDLs contendo o pigmento intercalado com o ânion do corante AM e sais de sódio de ambos os corantes, as propriedades mecânicas apresentaram leve aumento do módulo e tensão de ruptura e diminuição do alongamento em relação ao polímero puro e um comportamento inverso foi observado para o ânion AII, além do HDL contendo ânions cloreto hidratados.

  12. Cinética de cristalização não-isotérmica de resíduos de polietileno de alta densidade (PEAD

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    Helson Moreira da Costa

    2014-08-01

    Full Text Available Nesta investigação, diversos resíduos incolores ou coloridos pós-consumo de polietileno de alta densidade (PEAD foram caracterizados através do índice de fluidez (MFI e da calorimetria exploratória diferencial (DSC. A equação de Avrami modificada por Jeziorny, e os modelos de Kissenger e Friedman foram utilizados para descrever a cinética de cristalização não-isotérmica das amostras. Foi verificado que os pigmentos presentes no PEAD têm diferentes habilidades nucleantes durante o processo de cristalização, bem como diferentes efeitos sobre a taxa de cristalização e a energia de ativação necessária para o transporte de segmentos macromoleculares para a superfície do cristal em crescimento.

  13. Compósitos de partículas de madeira de Eucalyptus grandis, polipropileno e polietileno de alta e baixa densidades Composites of Eucalyptus grandis wood, polypropylene, and high and low-density polyethylene particles

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    Emerson Gomes Milagres; Benedito Rocha Vital; Ricardo Marius Della Lúcia; Alexandre Santos Pimenta

    2006-01-01

    Este trabalho teve como objetivo determinar as propriedades de painéis fabricados com mistura de partículas de madeira de Eucalyptus grandis, polietileno de alta densidade, polietileno de baixa densidade e polipropileno. Empregaram-se duas formulações adesivas (uréia-formaldeído e uréia-formaldeído contendo 0,5% de epóxi). De modo geral, as propriedades dos painéis foram afetadas pela composição das partículas. Os painéis com melhores propriedades foram fabricados com 75% de partículas de mad...

  14. Influência de aditivos na rigidez dielétrica do polietileno de alta densidade Additives influence on the high density polyethilene breakdown strenght

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    Marcelo M Ueki

    1997-12-01

    Full Text Available Neste trabalho são apresentados resultados de ensaios de ruptura dielétrica de curta duração com rampa de tensão positiva em amostras de polietileno de alta densidade (HDPE, modificadas com diferentes níveis de aditivos (dióxido de titânio, negro de fumo, antioxidante e estabilizante à ultravioleta. Esses resultados foram analisados estatisticamente pela distribuição de Weibull. Os parâmetros desta distribuição (β e Eγ foram determinados pelos métodos Gráfico e de Máxima Verossimilhança. Pôde-se concluir que os aglomerados de negro de fumo são prejudiciais à rigidez dielétrica e que o parâmetro de forma β desta distribuição pode ser empregado para avaliar as condições de mistura dos componentes na formulação, as quais afetam a rigidez dielétrica. Por meio de microscopia ótica pôde-se verificar que o parâmetro β, quando determinado pelo método Gráfico, representa melhor a dispersão dos referidos aditivos na matriz polimérica.In this work, it is presented results of the short-time dielectric breakdown test in high-density polyethylene (HDPE, with different additives levels (titanium dioxide, carbon black, antioxidant and UV stabilizer. For the dielectric breakdown test, an automated system developed in this department's polymer electrical properties lab has been used. The results have been analized by Weibull distribution. The parameters of Weibull distribution have been obtained by Graphical and Maximum Likelihood methods. One concluded that shape parameter β can be used to evaluate additives mixing condition in the compounds and graphical method better represents scattering of the results.

  15. Efeito dos solventes orgânicos sobre o comportamento físico-químico do polietileno de alta densidade (PEAD e polipropileno (PP

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    Thieres Magaive Costa Pereira

    2014-06-01

    Full Text Available O mercado brasileiro de embalagens empregado ao armazenamento de petróleo e seus derivados vem crescendo a cada ano, sendo constituídas basicamente por polietileno de alta densidade (PEAD e polipropileno (PP. Contudo durante o armazenamento, a matriz polimérica fica exposta ao óleo, comprometendo suas propriedades físicas e consequentemente a durabilidade do material. Portanto, estudos relacionados com a interação entre solventes orgânicos e a matriz polimérica tornam-se importantes. Neste trabalho, a interação do PEAD e PP com diferentes solventes apolares (tolueno, n-heptano, n-decano e n-tetradecano foram estudadas em função da temperatura (25, 50 e 80 ºC. Os valores de ganho de massa, coeficientes de difusão, sorção, permeabilidade e parâmetros de mecanismo de transporte foram calculados. O ganho de massa observado para o PP foi maior do que para o PEAD, em todas as temperaturas, sendo que o tolueno foi o solvente responsável pelo maior ganho de massa, atingindo o equilíbrio em um menor intervalo de tempo. Esse resultado corrobora com os valores de coeficiente de difusão e de permeabilidade, que aumentaram na seguinte ordem: n-heptano > n-decano > n-tetradecano. Uma ordem inversa foi observada para os solventes alifáticos quando os valores de coeficiente de sorção foram calculados. O mecanismo de transporte foi também estudado através da regressão dos dados de sorção, sendo classificado como anômalo.

  16. Reologia de polietileno de alta densidade tenacificado com polietileno elastomérico Rheology of high density polyethylene toughened with elastomeric polyethylene

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    Maria José O. C. Guimarães

    2003-06-01

    Full Text Available Neste trabalho foram estudadas as propriedades reológicas de polietileno de alta densidade (HDPE tenacificado com dois tipos de elastômeros metalocênicos à base de poli(etileno-co-octeno (EOC. Estes elastômeros são polímeros comerciais com diferenças quanto ao peso molecular, índice de fluidez e índice Dow de reologia (DRI. Misturas físicas de HDPE e EOC foram processadas em extrusora monorosca Wortex (L/D=32, à 230 °C e 50 rpm, utilizando percentagem mássica dos EOCs de 5% a 80%. As propriedades reológicas foram avaliadas em experimentos estacionários e dinâmicos a 190 °C e taxas de cisalhamento na faixa de 90 s-1 a 1500 s-1 e freqüências na faixa de 10-1 rad/s a 10² rad/s. As misturas HDPE/EOC exibiram pseudoplasticidade e comportamento reológico complexo. A complexidade do comportamento reológico foi acentuada com o aumento do peso molecular e da concentração de ramificações de cadeia longa (DRI do EOC.In this work rheological properties of high density polyethylene toughened with two different grades of metallocene elastomers based on poly(ethylene-co-octene were studied. These elastomers were commercial polymers differing in molecular weight, and Dow Rheology Index (DRI. Blends were processed in a Wortex single screw extruder (L/D=32, at 230 °C and 50 rpm, using mass fractions of EOC in the range from 5% to 80%. The rheological properties were evaluated in steady and dynamic experiments at 190 °C and shear rates in the range from 90 s-1 to 1500 s-1 with frequencies from 10-1 s-1 to 10-2 s-1. The blends exhibited pseudoplasticity and complex rheological behavior. The complex rheological behavior was intensified with increasing molecular weight and long chain branching proportion (DRI in the EOC elastomers.

  17. Compósitos de partículas de madeira de Eucalyptus grandis, polipropileno e polietileno de alta e baixa densidades Composites of Eucalyptus grandis wood, polypropylene, and high and low-density polyethylene particles

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    Emerson Gomes Milagres

    2006-06-01

    Full Text Available Este trabalho teve como objetivo determinar as propriedades de painéis fabricados com mistura de partículas de madeira de Eucalyptus grandis, polietileno de alta densidade, polietileno de baixa densidade e polipropileno. Empregaram-se duas formulações adesivas (uréia-formaldeído e uréia-formaldeído contendo 0,5% de epóxi. De modo geral, as propriedades dos painéis foram afetadas pela composição das partículas. Os painéis com melhores propriedades foram fabricados com 75% de partículas de madeira e 25% de partículas de polietileno de alta densidade. A adição de epóxi ao adesivo uréico aumentou os valores do módulo de ruptura, dureza Janka, e reduziu o inchamento, em espessura, de alguns painéis. As propriedades mecânicas da maioria dos painéis, exceto o módulo de elasticidade, ultrapassaram os valores mínimos estabelecidos na norma ANSI/A1-208/93.The objective of this work was to establish the properties of particleboards fabricated with blends of Eucalyptus grandis, low-density polyethylene, high-density polyethylene and polypropylene particles. Two adhesives formulations were used (urea-formaldehyde and urea-formaldehyde plus 0,5% of epoxy adhesive. Panel properties were affected by particle composition. Panels with best properties were fabricated with 75% of wood particles and 25% of high density polypropylene. The addition of epoxy to the urea-formaldehyde adhesive improved of the values of modulus of rupture, hardness and reduced the amount of thickness swelling. Except for the modulus of elasticity, board properties meet grade M-2 ANSI/A1-208/93 requirements.

  18. Consumo de alimentos de alta densidad energética en los beneficiarios del programa Oportunidades. El caso del Área Metropolitana de Monterrey

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    Óscar Alfonso Martínez Martínez

    2012-01-01

    refrescos y frituras, entre los beneficiarios y no beneficiarios de dicho programa. Se encontró que no existen diferencias estadísticamente significativas en su consumo, pero sí que las ingestas son altas para ambos grupos.

  19. Triglycerides and high-density lipoprotein cholesterol are associated with insulinemia in adolescents Triglicéridos y colesterol de lipóproteína de alta densidad asociados con insulina en adolescentes

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    Guadalupe Ramírez-López

    2006-08-01

    Full Text Available OBJECTIVE: The aim of this study was to evaluate the association between lipids and insulin concentration in adolescents. MATERIAL AND METHODS: A cross-sectional study of 350 adolescents aged 14-19 years old from a public high school in Guadalajara, in the state of Jalisco, Mexico, was conducted. Fasting insulin concentration was determined using microparticle enzyme immunoassay; total cholesterol and triglycerides were detected by standard enzymatic procedures; and low- and high-density lipoproteins were found using standard precipitation methods. Statistical analysis included linear multivariate regression. RESULTS: Serum triglycerides were associated positively with insulin fasting (beta= 0.003, p= 0.0001 and high-density lipoprotein cholesterol was negatively associated with insulin fasting in male adolescents 18-19 years old (beta= -0.03, p= 0.012. CONCLUSIONS: The relationships between triglycerides and insulin and between high-density lipoprotein cholesterol and insulin are already present in adolescence.OBJETIVO: Evaluar la relación entre lípidos e insulina en adolescentes. MATERIAL Y MÉTODOS: Estudio transversal en 350 adolescentes de 14 a 19 años de preparatoria pública en Guadalajara, Jal., México. La insulina se midió por inmunoensayo enzimático de micropartícula, el colesterol total y triglicéridos por pruebas enzimáticas estándares, y las lipoproteínas de baja y alta densidad por métodos de precipitación. Se utilizó análisis de regresión lineal multivariada. RESULTADOS: Los triglicéridos se asociaron en forma positiva con insulina (beta= 0.003, p= 0.0001 y la lipoproteína de alta densidad se asoció en forma negativa con insulina en varones de 18-19 años de edad (beta= -0.03, p= 0.012. CONCLUSIONES: En los adolescentes, los triglicéridos y las lipoproteínas de alta densidad están asociados con la insulinemia.

  20. Efecto del ejercicio en subpoblaciones de lipoproteínas de alta densidad y en la presión arterial

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    Nieto Cárdenas, Olga Alicia; García Cardona, Diana María; Jiménez, Jorge Alberto; Landázuri, Patricia

    2013-01-01

    Objetivo Determinar la relación del ejercicio con los niveles séricos de la apoA-I y las subpoblaciones de HDL2 y HDL3, en personas hipertensas de la Ciudad de Armenia - Quindío.Métodos La intervención fueron dos meses de ejercicio. La presión arterial se tomó con las recomendaciones del Ministerio de Salud de Colombia. Las subpoblaciones de HDL se midieron con el método del precipitado ionico y la apoA-I se midió con la técnica de nefelometría de bindig site.Resultados Los datos se analizaro...

  1. Higher glandular trichome density in tomato leaflets and repellence to spider mites Alta densidade de tricomas glandulares em tomateiro e aumento da repelência a ácaros rajados

    Directory of Open Access Journals (Sweden)

    Wilson Roberto Maluf

    2007-09-01

    ácaro na superfície do folíolo de tomateiro, após 20, 40 e 60 min. Os biotestes de repelência ao ácaro rajado demonstraram que a alta densidade de tricomas glandulares, especialmente de tipo VI, influencia negativamente a distância média percorrida pelos ácaros na superfície do folíolo. Plantas com número de tricomas glandulares elevado podem ser selecionadas para se obterem genótipos com alto índice de repelência aos ácaros.

  2. Modificação química de celulose para utilização em mistura com polietileno de alta densidade

    OpenAIRE

    Ciulik, Claudio Batista

    2010-01-01

    Resumo: O polietileno, um dos polímeros mais usados no mundo é também, um dos principais resíduos poliméricos encontrados nos lixões dos grandes centros urbanos. Este e outros problemas como a pequena resistência ao desgaste, alta transmissão de odores e baixa resistência à migração de óleos e gorduras, torna promissor o estudo de novas composições com este termoplástico, agregando ao mesmo, substâncias que enriqueçam suas propriedades tal como a celulose. Sabendo das grandes diferenças de pr...

  3. Compensatory growth of Malaysian prawns reared at high densities during the nursery phase Crescimento compensatório em camarões-da-malásia cultivados sob altas densidades durante a fase de berçário

    Directory of Open Access Journals (Sweden)

    H.L.A. Marques

    2011-04-01

    Full Text Available The objective of this work was to verify the occurrence of compensatory growth in Malaysian prawn (Macrobrachium rosenbergii reared in pens, after being stocked in cages under high densities during nursery phase. The experiment was carried out in 0.5 m² cages and 2-m² pens set in natural bottom pond with 2,400 m². Prawn post-larvae (PL with an average weight of 0.026 ± 0.012 g (nursery phase were initially stocked in 16 cages at the densities of 50, 400, 800 and 1,200 PL m-2. Sixty days later, prawns were transferred to 16 growing pens, at the density of 12 prawns m-2. Initial average weight of the prawn in this phase was the final average weight registered in the nursery phase, as follows: 50 PL m-2 = 2.3 ± 0.3 g; 400 PL m-2 = 0.5 ± 0.03 g; 800 PL m-2 = 0.3 ± 0.05 g and 1,200 PL m-2 = 0.1 ± 0.01 g. Commercial rations for prawns (35% crude protein were given once a day, in the afternoon. After 244 days, survival, average weight and biomass did not differ significantly among prawns with different initial average weight. Relative growth rate was significantly greater in prawns previously stocked at 1,200 PL m-2 and feed conversion efficiency was significantly better for those previously stocked at 400 and 1,200 PL m-2. These results suggest the existence of partial compensatory growth in M. rosenbergii, what can successfully carry on stocking of prawns of this species at high densities in the nursery phase.Este trabalho foi realizado com o objetivo de verificar a ocorrência de crescimento compensatório em camarões-da-malásia (Macrobrachium rosenbergii cultivados em cercados, após serem estocados em gaiolas sob altas densidades durante a fase de berçário. O experimento foi conduzido em gaiolas com 0,5 m² e cercados com 2 m² instalados em um viveiro de fundo natural com 2.400 m². Pós-larvas (PL de camarões com peso médio de 0,026 ± 0,012 g (fase de berçário foram inicialmente estocadas em 16 gaiolas, nas densidades de 50, 400

  4. ALTAS DENSIDADES DE PLANTIO NA CULTURA DO ABACAXI CV. SMOOTH CAYENNE, SOB CONDIÇÕES DE SEQUEIRO HIGH PLANTING DENSITY FOR THE SMOOTH CAYENNE PINEAPPLE CROP, GROWN UNDER RAINFED CONDITIONS

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    LUCIANA LIMA DE ALMEIDA SANTANA

    2001-08-01

    Full Text Available No Brasil têm-se usado densidades de plantio relativamente baixas para a obtenção de frutos grandes, com reflexos negativos na produtividade da cultura do abacaxi. No entanto, frutos cada vez menores têm sido comercializados no mercado internacional, o que poderá também ocorrer no mercado nacional. Este trabalho teve o objetivo de avaliar o efeito de altas densidades em sistemas de plantio em filas duplas sobre a produção quantitativa e qualitativa de abacaxi cv. Smooth Cayenne, sob condições de sequeiro. Densidades de plantio, variando de 51.280 plantas/ha a 100.000 plantas/ha, foram estudadas em delineamento experimental de blocos casualizados, com cinco repetições e doze tratamentos, distribuídos em esquema fatorial 4 x 3, correspondendo a quatro combinações de espaçamentos entre linhas duplas e entre linhas simples na fila dupla (90cm x 40 cm, 90 cm x 30 cm, 80 cm x 30 cm , 70 cm x 30 cm e três espaçamentos entre plantas nas linhas de plantio (30 cm, 25 cm, 20 cm. A análise de variância determinou diferença estatística apenas para a produtividade, em função do espaçamento entre plantas na linha de plantio, sendo mais elevada para o espaçamento de 20 cm. O peso do fruto, as suas dimensões e a sua qualidade (açucares, acidez, teor de suco, relação açúcares/acidez não foram significativamente influenciados pelas densidades de plantio estudadas, mantendo-se dentro dos padrões da cultivar. Para cada aumento de 10.000 plantas por hectare, a produtividade cresceu em 8,27 t/ha e o peso médio do fruto caiu 102 g. Nas condições ambientais dos Tabuleiros Costeiros do Norte da Bahia, a cultura do abacaxi cv. Smooth Cayenne apresenta potencial para uso em altas densidades de plantio, mesmo em cultivo de sequeiro, podendo-se atingir produtividade acima de 80t/ha e peso médio do fruto superior a 1,0 kg.In Brazil, relatively low planting densities have been used to obtain large fruits, with negative effects on pineapple

  5. Concentração plasmática de colesterol total e lipoproteína de alta densidade em novilhas mestiças doadoras de embriões tratadas com somatotropina bovina recombinante Total plasma cholesterol and high-density lipoprotein levels in crossbred heifer embryo donors treated with bovine recombinant somatotropin

    Directory of Open Access Journals (Sweden)

    Á.M. Borges

    2001-10-01

    Full Text Available O objetivo do experimento foi o de estudar as concentrações plasmáticas de colesterol total e lipoproteína de alta densidade (HDL em novilhas mestiças tratadas com somatotropina bovina recombinante (rbST. Coletas de sangue foram feitas durante dois ciclos estrais, normal e superovulado, em 26 fêmeas distribuídas em dois tratamentos: T1 = aplicação de 500mg de rbST no terceiro dia do ciclo estral utilizado para a superovulação e T2 = controle. Análises dos metabólitos sangüíneos foram feitas utilizando-se o método enzimático, cujas concentrações médias plasmáticas de colesterol total e de HDL durante o ciclo estral normal não foram diferentes (P>0,05 entre os dois tratamentos: 87,9 e 25,8mg/dl e 85,9 e 26,7mg/dl para T1 e T2, respectivamente. O ciclo estral utilizado para a superovulação foi dividido em três períodos: P1 = do estro à inseminação artificial (0 ao15º dia, P2 = da inseminação artificial até a coleta de embriões (15º ao 21º dia e P3 = da coleta até o final do período experimental (21º ao 27º dia. As concentrações plasmáticas de colesterol total e HDL no P1 não diferiram entre os tratamentos (P>0,05. Em P2 e P3 houve diferença nas concentrações de HDL e colesterol total entre os dois tratamentos: 29,0 e 88,5mg/dl (T1 e 27,1 e 81,8mg/dl (T2 no P2; e 30,4 e 88,0mg/dl (T1 e 26,6 e 80,5mg/dl (T2 no P3, respectivamente (PThe objective of the experiment was to study the total cholesterol and high-density lipoprotein (HDL levels in crossbred heifers treated with bovine recombinant somatotropina (rbST. Blood samples were collected for two estrous cycles, normal and superovulated, from 26 animals randomly distributed into two treatments: T1 - injected with 500mg rbST on day 3 of estrous cycle and T2 - control. The lipidic metabolite levels were determined by an enzymatic method, and plasma levels of total cholesterol and HDL in normal estrous cycle did not differ (P>0.05 between treatments: 87

  6. Nuevos actores en la gestión de estrategias inclusivas para vivienda de alta densidad: el caso de San José de Costa Rica New players for the management of inclusive strategies for densely populated housing: San José de Costa Rica Novos atores para a gestão de estratégias inclusivas na alta densidade habitacional: o caso de San José de Costa Rica

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    Daniel Morgan Ball

    2011-06-01

    Full Text Available Resumen: Debido a los altos costos del suelo urbano y construcción en altura asociados con vivienda de alta densidad, normalmente, familias de clase media-baja están excluidas como potenciales habitantes de proyectos de regeneración y repoblamiento de zonas céntricas dela ciudad. El objetivo es exponer una estrategia sobre que un rango más amplio de clases sociales habite este tipo de proyecto, mediante una política de subsidios basada en la construcción de edificios mixtos que generan, en cada proyecto, rentas que pueden emplearseen subsidios para familias de menores ingresos en la ciudad de San José de Costa Rica. Se establece una estrategia para definir la ubicación de proyectos, así como un modelo de gestión urbana y gestión de proyectos, a fin de implementar la estrategia. Como resultado se definen los roles de dos nuevos actores: la asociación de vivienda y la corporación municipal en la gestión de proyectos de vivienda colectivos. Abstract:Due to high costs involved in urban soil and construction in height related to high density housing lower middle class are being excluded as potential inhabitants of regeneration and repopulation projects in central areas of the city. The aim is to reveal a strategy for a wider range of people to live in these projects, using a housing allowance policy based on the construction of mixed buildings whose income will be used as the allowance for San José de Costa Rica’s low-income families. A strategy to agree on the location of the projects as well as a urban management model and project management to implement the strategy are stated. As a result roles for the new actors are defined: housing association and town council in collective housing projects’ management.Resumo:Devido aos elevados custos de solo urbano e da construção em altura, associados com alta densidade habitacional famílias de médias e baixas rendas são, usualmente, excluídas como moradores potenciais de projetos

  7. Movilización intracelular de colesterol mediada por apoA-I y dHDL: dominios proteicos involucrados

    OpenAIRE

    Cabaleiro, Laura Virginia

    2013-01-01

    La apoA-I cumple un rol muy importante en el transporte reverso del colesterol (TRC), es el componente mayoritario de las lipoproteínas de alta densidad (HDL) que desempeñan diversas funciones en las distintas etapas del TRC. Resultados previos de este laboratorio permiten postular la hipótesis de que la región central de la apoA-I, formada por el par de hélices tipo Y, estaría involucrada en la interacción con la membrana celular, que sería importante para el eflujo de lípidos y la movilizac...

  8. Efeito do bebedouro e da densidade no desempenho de frangos alojados em alta temperatura Effect of type of water facility and density on performance of broiler reared in hot-climate

    Directory of Open Access Journals (Sweden)

    José H.V. Silva

    2005-12-01

    Full Text Available Com o objetivo de avaliar o efeito do bebedouro pendular (BP e do bebedouro alternativo (BALT, e de diferentes densidades (10 e 14 aves m-2 sobre o desempenho de 240 frangos de corte de 12 a 18, 19 a 38 e de 39 a 46 dias de idade, realizou-se este experimento em condições de temperatura média de 27,6 ºC e umidade relativa de 70,4%, no qual foi utilizado um delineamento inteiramente casualizado em esquema fatorial 2 x 2 (dois bebedouros x duas densidades, resultando em quatro tratamentos constituídos de cinco repetições de 10 aves. O BALT foi desenvolvido com base no conceito de amplo espaço de calha circular e alta profundidade de lâmina de água (5 cm para permitir a imersão do bico e das faces da ave. Na alimentação das aves, foram utilizadas rações comerciais, cujo consumo (CR caiu, enquanto a conversão alimentar (CA melhorou, quando o BALT foi empregado de 12 a 18 dias. Não houve efeito do bebedouro sobre o CR, ganho de peso (GP e CA no período total. A D14 (14 aves m-2 afetou o GP e o CR de 19 a 38 e de 39 a 46 dias e também no período total, mas a CA não foi alterada. O BALT não afeta o desempenho de frangos de corte, podendo ser usado como opção de baixo custo ao BP. A análise econômica pelo índice de rentabilidade relativa mostrou que o BALT e a D14 oferecem 1 e 5,9% de retorno a mais que o BP e a D10, (10 aves m-2 respectivamente.The experiment was undertaken in conditions of average temperature of 27.6 ºC and relative humidity of 70.4%, with the objective to evaluate bell (BD and alternative (ALT water facility and stocking densities (SD of 10 and 14 broilers m-2 (SD10 and SD14, on performance of 240 broiler chickens of 12 to 18, 19 to 38 and 39 to 46 days of age, allotted in boxes in a completely randomized design in 2 x 2 factorial arrangement (two types of drinking facility and two stocking densities, resulting in four treatments, each one with five replications of ten birds. The ALT was developed based on

  9. Polietileno de Alta Densidade Tenacificado com Elastômero Metalocênico: 1. Propriedades Mecânicas e Características Morfológicas Rubber Toughened High Density Polyethylene: 1. Mechanical Properties and Morphological Characteristics

    Directory of Open Access Journals (Sweden)

    Maria José O. C. Guimarães

    2002-01-01

    Full Text Available Neste trabalho foram estudadas as propriedades mecânicas e morfológicas de polietileno de alta densidade (HDPE tenacificado com dois tipos de elastômeros metalocênicos à base de etileno/1- octeno (EOC. Esses elastômeros são polímeros comerciais com diferenças quanto ao peso molecular, índice de fluidez e índice Dow de reologia (DRI. Misturas físicas de HDPE e EOC foram processadas em extrusora monorosca Wortex (L/D=32, à 230°C e 50 rpm, utilizando percentagem mássica do EOC de 5% a 80%. Foi observado um efeito sinergístico nas propriedades tênseis e características de supertenacificação para materiais contendo proporções do EOC maiores do que 5%. Cavitação, deformação plástica e cavitação fibrilada foram observados nos processos de deformação. Materiais contendo até 50% do EOC apresentaram morfologias dispersas com domínios elastoméricos esféricos, distribuídos uniformemente e com tamanho médio de partícula na faixa de 0,30 a 0,45 µm. A tenacificação de HDPE com os elastômeros etilênicos produziu materiais com boas propriedades e compatibilização tecnológica devido à existência de baixa tensão interfacial entre esses polímeros.The mechanical and morphological properties of high density polyethylene (HDPE toughened with two different grades of metallocene elastomers based on ethylene/1- octene (EOC were studied. These elastomers were commercial polymers differing in molecular weight, melt flow index and Dow rheology index (DRI. Blends were processed in a Wortex single screw extruder (L/D=32, at 230°C and 50 rpm, using mass fraction weight percent of EOC in the range from 5% to 80%. A synergistic effect on the tensile properties and supertough behavior for blends with EOC concentrations higher than 5% was observed. Cavitation, plastic deformation and fibrillized cavitation were observed in the deformation processes. Materials containing up to 50% of EOC exhibited dispersed morphologies with EOC

  10. Fertilización de base en un cultivo inicial de pecan con dos marcos de plantación de alta densidad Effect of different fertilization strategies on pecan growth parameters under two high density plantation frames

    Directory of Open Access Journals (Sweden)

    Lidia Giuffré

    2011-07-01

    Full Text Available El pecán, Carya illinoensis Koch, es una especie cuyo fruto es reconocido como un alimento altamente saludable. Su cultivo se encuentra en expansión en la Argentina pero existen muy pocas investigaciones sobre fertilización y sistemas de plantación. Los objetivos del trabajo fueron caracterizar algunas propiedades físico-químicas y químicas de un suelo en el que se inicia un cultivo de pecán, y comparar tratamientos de fertilización de base (FB en dos marcos de plantación de alta densidad (MP. Se realizó una plantación de pecán en Villanueva (provincia de Buenos Aires, sobre un suelo Hapludol taptoárgico, con dos marcos de plantación: 10 x 10 m (marco real: MR y 8 x 8 m (tresbolillo: TR. El diseño del experimento fue en parcelas divididas con cuatro repeticiones. La parcela principal fueron los dos marcos de plantación, y las subparcelas fueron los distintos tratamientos de fertilización base: Compost (C, Fósforo (P, Nitrógeno (N y Control sin fertilización base (T. Las determinaciones para evaluar el crecimiento de las plantas de pecán fueron: la altura de las plantas y el diámetro del tronco. Con respecto a la fertilidad del suelo, la fertilización fosforada y el agregado de compost permitieron aumentar significativamente los niveles de P-Bray. El tratamiento con fertilización orgánica: compost, presentó un incremento significativo en altura de los pecanes en el marco de plantación 8 x 8 m, que no se manifestó en ningún caso en los diámetros del tronco, con una interacción MP x FB significativa (P=0,01 para la variación de altura al primer año. La variación del volumen del árbol durante el año de experimentación no presentó efectos significativos según el marco de plantación ni la fertilización base aplicada.The fruit of the pecan tree, Carya illinoensis Koch, is considered a very healthy food. In Argentina, pecan cultivation has been expanding rapidly but very little research has been conducted on

  11. Rejuvenecimiento de manos con ácido hialurónico de alta densidad: estudio prospectivo en 29 pacientes Hands rejuvenation with high density hyaluronic acid: prospective study in 29 patients

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    J.M. Alcolea

    2012-12-01

    Full Text Available El objetivo del presente estudio prospectivo es valorar a corto, medio y largo plazo, la eficacia en el rejuvenecimiento de las manos de la inyección subcutánea de ácido hialurónico (AH, Macrolane® 20, de alta densidad y partículas grandes, teniendo en cuenta el beneficio del tratamiento, la satisfacción de los pacientes y las posibles complicaciones. Este estudio se realizó entre mayo del 2010 y diciembre del 2011. Se seleccionaron 29 pacientes al azar entre 51 y 74 años de edad con fototipos II a IV, a los que se les inyectó AH para rejuvenecer las manos. La cantidad de AH inyectada en cada mano fue de 1 a 2 ml. Se realizaron controles sistemáticos en la 2ª semana, en los meses 1º, 3º, 6º, 9º y 12º. Se tuvieron en cuenta las complicaciones en cada paciente en todos los controles. En el primer control, en la 2ª semana, junto al examen clínico se practicó examen ecográfico a fin de determinar si sería necesaria una segunda inyección de AH. En cada uno de los controles los pacientes contestaron a un formulario para indagar sobre su grado de satisfacción con el tratamiento. Solo 1 paciente presentó edema y 3 tuvieron equimosis leve; 2 pacientes manifestaron dolor leve con las inyecciones y 2 requirieron una segunda inyección tras la valoración en la 2ª semana. La satisfacción de los pacientes en los controles superó la valoración clínica y fotográfica. En nuestra opinión, el rejuvenecimiento de las manos con este tipo de AH de grandes partículas tiene una baja tasa de complicaciones y es bien tolerado, con un alto grado de satisfacción por parte de los pacientes y una notable mejoría de los parámetros estudiados: arrugas, aspecto de la atrofia dérmica y subcutánea y disminución de los relieves óseos, tendinosos y venosos. La valoración tanto subjetiva como objetiva se hizo hasta el año de seguimiento con buenos resultados.The aim of this prospective study is to assess the efficacy of a high density

  12. Metodología para el diseño de diagnósticos interferométricos de alta resolución espacial para la medida de perfiles de densidad electrónica en plasmas de fusión: el interferómetro heterodino de haz expandido y de dos longitudes de onda del Stellarator TJ-II

    OpenAIRE

    Pedreira Conchado, Pablo

    2011-01-01

    Este trabajo de tesis doctoral desarrolla una metodología para el diseño de diagnósticos interferométricos multicanal para la medida de perfiles de densidad electrónica de alta resolución espacial en plasmas de fusión confinados magnéticamente y su validación a través del diseño de un diagnóstico para el stellarator TJ-II. A mediados del siglo XX surge la fusión termonuclear como una solución y alternativa a los problemas que se derivan del uso de los combustibles fósiles co...

  13. Avaliação do efeito de um óleo parafínico sobre o comportamento físico-químico de tubulações de polietileno de alta densidade Evaluation of the effect caused by a paraphinic oil on the physicochemical behavior of high-density polyethylene pipes

    OpenAIRE

    Amélia A. U. Torres; José Roberto M. d'Almeida; Jean-Pierre Habas

    2010-01-01

    Nesse trabalho são investigados os efeitos causados por um óleo parafínico sobre o comportamento físico-químico de dutos de polietileno de alta densidade (PEAD). Os efeitos causados nos dutos de PEAD foram avaliados em função do tempo e da temperatura de exposição através de análises gravimétrica e termogravimétrica e por espectroscopia no infravermelho. Os dados gravimétricos puderam ser satisfatoriamente descritos pela Lei de Fick. Os resultados de FTIR indicaram que não ocorreram modificaç...

  14. HDL Cholesterol Test

    Science.gov (United States)

    ... limited. Home Visit Global Sites Search Help? HDL Cholesterol Share this page: Was this page helpful? Also ... HDL; HDL-C Formal name: High-density Lipoprotein Cholesterol Related tests: Cholesterol ; LDL Cholesterol ; Triglycerides ; Lipid Profile ; ...

  15. Waist-to-height ratio (WHtR) and triglyceride to HDL-C ratio (TG/HDL-c) as predictors of cardiometabolic risk.

    Science.gov (United States)

    Weiler Miralles, Clara Silvana; Wollinger, Luana Maria; Marin, Débora; Genro, Julia Pasqualini; Contini, Veronica; Morelo Dal Bosco, Simone

    2015-05-01

    Introducción: La concentracion excesiva de grasa en la region abdominal se relaciona con un mayor riesgo de desarrollar enfermedad cardiovascular (ECV). Se han realizado estudios para identificar los indicadores simples y eficaces de la obesidad abdominal y el riesgo cardiometabolico asociados con el uso de parametros simples, como las medidas antropometricas y bioquimicas. El / alta densidad de colesterol de lipoproteinas de trigliceridos (TG / HDL-c) se ha propuesto como un enfoque mas practico y facil de usar marcador aterogenico, junto con la relacion cintura-estatura (RCEst), lo que hace que una herramienta superior para separar cardiometabolico riesgos relacionados con el sobrepeso / obesidad cuando se compara con el indice de masa corporal (IMC). Objetivo: Verificar la aplicabilidad de la RCEst y la relacion TG / HDL-c como predictores de riesgo cardiometabolico. Métodos: Este estudio transversal se llevo a cabo en el Departamento de Nutricion del Centro Universitario UNIVATES, donde se recogieron datos antropometricos y bioquimicos de los participantes. El analisis estadistico se realizo mediante el paquete estadistico para el software de Ciencias Sociales (SPSS) 20,0, con un nivel de significacion del 5% (p.

  16. Bases morfofisiológicas para maior tolerância dos híbridos modernos de milho a altas densidades de plantas Morpho-physiological bases for greater tolerance of modern maize hybrids to high plant densities

    Directory of Open Access Journals (Sweden)

    Luís Sangoi

    2002-08-01

    Full Text Available O lançamento de híbridos de milho tolerantes ao aumento da densidade de plantas contribuiu para o incremento do potencial produtivo da cultura na segunda metade do século XX. Objetiva-se com esta revisão de literatura discutir características morfológicas, fisiológicas, fenológicas e alométricas que contribuíram para maior adaptação do milho a elevadas densidades de plantas. Os processos de seleção utilizados pelos melhoristas minimizaram a natureza protândrica da planta, reduzindo o tamanho do pendão. Isso propiciou desenvolvimento alométrico mais equilibrado entre as inflorescências masculina e feminina, limitou a esterilidade feminina e favoreceu a sincronia entre antese e espigamento. O ideotipo de planta compacto dos híbridos modernos, caracterizado pela presença de plantas baixas, com menor número de folhas e folhas eretas, melhorou a qualidade da luz no interior do dossel, contribuindo para reduzir a dominância apical do pendão sobre as espigas. A menor produção de fitomassa reduziu a competição intra-específica e aumentou a eficiência de uso dos fatores ambientais, disponibilizando mais carboidratos para atender às diferentes demandas da planta na fase reprodutiva. O maior equilíbrio nas relações entre fonte e dreno contribuiu para retardar a senescência foliar, resultando em maior absorção de nutrientes e maior eficiência de uso do nitrogênio. O desenvolvimento de híbridos com menor estatura e espigas mais próximas do solo reduziu a quantidade de plantas acamadas e quebradas. A compreensão das bases morfofisiológicas responsáveis pela maior tolerância do milho à competição intra-específica auxiliará melhoristas e fisiologistas a maximizar a eficiência do arranjo de plantas para alcançar altos rendimentos.The release of maize hybrids tolerant to high plant densities has contributed to enhance the potential for grain yield in this crop in the second half of last century. This review aims

  17. Patella Alta

    OpenAIRE

    Cakmak, Mehmet; Taser, Omer; Karamehmetoglu, Mahmut; Domanic, Unsal

    2004-01-01

    Patella alta is investigated with Insall-Salvati method in lateral X-rays obtained with the knee in 30 flexion in 26 cases with recurrent dislocation of the patella and in 16 cases diagnosed to have chondromalasia. Patella alta is identified in 12 cases with recurrent dislocation of patella and in 9 cases with chondromalasia. Patella alta, which is one of the significaint consative agents of patella femoral instrability, is reviewed under the literature data.

  18. [ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS].

    Science.gov (United States)

    Awad, Fernanda; Contreras-Duarte, Susana; Molina, Patricia; Quiñones, Verónica; Serrano, Valentina; Abbott, Eduardo; Maiz, Alberto; Busso, Dolores; Rigotti, Attilio

    2015-09-01

    Introducción: las lipoproteínas de alta densidad (HDL) tienen un importante efecto protector cardiovascular mediado por su función durante el transporte reverso del colesterol, así como por otras actividades, incluyendo una significativa acción antiinflamatoria y antioxidante. La funcionalidad antiinflamatoria y antioxidante de las HDL está alterada en los pacientes diabéticos crónicos estables, aunque no existe mayor información en caso de una crisis hiperglicémica. Objetivo: determinar si durante un estado de descompensación diabética aguda las partículas de HDL exhiben un deterioro de su función antioxidante y si esta logra recuperarse una vez resuelto el cuadro agudo. Métodos: la actividad antioxidante de las HDL se midió mediante un ensayo de fluorescencia in vitro en muestras plasmáticas de pacientes diabéticos con descompensación aguda obtenidas tanto al ingreso, alcanzada la resolución intrahospitalaria del evento agudo, así como en un control ambulatorio post-hospitalización. Como comparación, se analizaron partículas de HDL de algunos sujetos sanos como condición control. Resultados: la actividad antioxidante de las HDL en pacientes con descompensación diabética aguda fue significativamente menor a la observada en el grupo control sano, y esta se fue recuperando progresivamente hasta normalizarse en el momento del control ambulatorio. La crisis hiperglicémica también demostró una baja actividad plasmática de la enzima antioxidante paraoxonasa- 1, la cual aumentó significativamente en el control ambulatorio. Conclusión: las partículas de HDL presentes en pacientes con una descompensación diabética aguda presentan una reducción significativa y reversible de su capacidad antioxidante, probablemente como consecuencia de una alteración en la actividad de la paraoxonasa-1.

  19. High population density survival of the sea urchin Diadema antillarum (Philippi 1845 to a category 5 hurricane in southern Mexican Caribbean Supervivencia de una alta densidad poblacional del erizo de mar Diadema antillarum (Philippi 1845 a un huracán categoría 5 en el sur del Caribe mexicano

    Directory of Open Access Journals (Sweden)

    Pablo Jorgensen

    2008-12-01

    Full Text Available The vulnerability of the sea urchin Diadema antillarum to the impact of the category 5 hurricane "Dean" was assessed at a back-reef area of Mahahual (Southern Mexican Caribbean. Seventy days after Dean, there was a high mean Diadema population density of 12.6 ± 4.3 (SD; from here forward ind m-2, with a large mean individual test diameter of 59.2 ±9.8 mm. This population was comparable to a previous report for the same area, just before the landfall of Dean on 21 August 2007. Immigration of adults from deeper fore-reef sites after Dean across the reef-crest was unlikely, considering the homing behavior displayed by tagged urchins. The degree of physical alteration of the habitat indicated that Diadema may survive higher hurricane-generated disturbances than those reported in previous works. These results have strong implications on the conservation of the Mexican Caribbean coral reefs since the Diadema populations surveyed have a high grazing activity and are persistent against hurricanes impact.La vulnerabilidad del erizo de mar Diadema antillarum al impacto del huracán categoría 5 "Dean" fue evaluada en el arrecife posterior de Mahahual, México. Setenta días después de la recalada de Dean fue estimada una alta densidad media poblacional de Diadema de 12.6 ind m-2 (DE = 4.3, con un elevado tamaño individual promedio de 59.2 mm de diámetro (DE = 9.8. Esta densidad fue comparable a la de un reporte previo para la misma zona, días antes del paso de Dean el 21 de agosto de 2007. Considerando la fidelidad al refugio mostrado por erizos marcados, la inmigración de adultos desde el arrecife anterior después del paso de Dean fue poco factible. El nivel de destrucción del hábitat indica que Diadema sería más persistente al impacto directo de huracanes que lo sugerido por estudios anteriores. Debido al elevado potencial de pastoreo de las poblaciones locales de Diadema, y a su persistencia al impacto de huracanes, los resultados de este

  20. Cultivos de alta densidad celular por retención interna: aplicación a la fermentación continua de etanol High cell density cultures produced by internal retention: application in continuous ethanol fermentation

    Directory of Open Access Journals (Sweden)

    Godoy Rubén Darío

    2004-12-01

    Full Text Available El etanol ha generado gran interés por su potencial como combustible alternativo. No obstante, para que este producto sea competitivo económicamente, es necesario desarrollar procesos de fermentación que incrementen la baja productividad volumétrica lograda en cultivos convencionales (por lote o continuo, por medio de técnicas que permitan altas concentraciones celulares y reduzcan la inhibición por producto. Uno de los métodos empleados frecuentemente involucra la recirculación celular; por ello, en este trabajo se desarrolló un reactor de membrana incorporando un módulo de filtración, con unidades tubulares de 5 u,m en acero inoxidable, dentro de un fermentador de tanque agitado de 3L, para investigar su aplicación en la producción continua de etanol. Los efectos de la concentración celular y la caída de presión transmembranal sobre el flux de permeado fueron evaluados para probar el desempeño del módulo de filtración. Previa selección de las condiciones de fermentación (30 °C, 1,25 -1,75 vvm, pH 4,5, el sistema con retención celular interna fue operado en el cultivo continuo de Saccharomyces cerevisiae a partir de sacarosa. La permeabilidad de las unidades filtrantes fue mantenida mediante la aplicación de pulsos de aire. Más del 97% de las células cultivadas fueron retenidas en el fermentador, alcanzándose una concentración celular de 51 g/L y una productividad promedio de etanol, en el cultivo con retención celular, de 8,51 g/L.h, la cual fue dos veces mayor a la que se obtiene en un cultivo continuo convencional. Palabras clave: reactor de membrana, Saccharomyces cerevisiae, fermentación alcohólica, recirculación celular.Ethanol has provoked great interest due to its potential as an alternative fuel. Nevertheless, fermentation processes must be developed by increasing the low volumetric productivity achieved in conventional cultures (batch or continuous to make this product become economically competitive

  1. Avaliação do efeito de um óleo parafínico sobre o comportamento físico-químico de tubulações de polietileno de alta densidade Evaluation of the effect caused by a paraphinic oil on the physicochemical behavior of high-density polyethylene pipes

    Directory of Open Access Journals (Sweden)

    Amélia A. U. Torres

    2010-01-01

    Full Text Available Nesse trabalho são investigados os efeitos causados por um óleo parafínico sobre o comportamento físico-químico de dutos de polietileno de alta densidade (PEAD. Os efeitos causados nos dutos de PEAD foram avaliados em função do tempo e da temperatura de exposição através de análises gravimétrica e termogravimétrica e por espectroscopia no infravermelho. Os dados gravimétricos puderam ser satisfatoriamente descritos pela Lei de Fick. Os resultados de FTIR indicaram que não ocorreram modificações estruturais importantes no PEAD exposto a esse óleo e que o processo de envelhecimento do PEAD foi do tipo físico, já que nenhuma alteração na estrutura química do polímero foi detectada.The effects caused by a paraphinic oil on the physicochemical behavior of high-density polyehtylene pipes were investigated, as a function of time and temperature. These effects were evaluated by thermogravimetric and gravimetric analysis and by FTIR. The gravimetric data were satisfactorily described using the Fick's law, and the FTIR results showed that no main structural modifications have occurred after exposure of the HDPE pipes to this oil. From the results obtained it was concluded that physical aging was occurring, since the chemical structure of the polymer was not altered.

  2. High density of defoliated tomato plants in protected cultivation and its effects on development of trusses and fruits Alta densidade com desfolhamento de plantas de tomateiro em cultivo protegido e seus efeitos sobre o desenvolvimento de inflorescências e frutos

    Directory of Open Access Journals (Sweden)

    Miguel A. Sandri

    2002-09-01

    ground area seems to be the upper limit in maximizing the number of set fruits of this crop.O número de frutos em plantas de tomateiro cultivadas em alta densidade e com índice de área foliar similar mantido através de desfolhamento foi determinado em três condições ambientais, no interior de túneis de polietileno. O experimento 1 foi conduzido no outono, com radiação solar média recebida pela cultura de 8,0 MJ m-2 dia-1 e temperatura média exterior de 18,1ºC. Os experimentos 2 e 3 foram conduzidos na primavera, com temperatura média exterior de 19,7ºC. No experimento 2, a radiação solar média recebida pela cultura foi de 12,4 MJ m-2 dia-1, enquanto no experimento 3 foi reduzida para 5,9 MJ m-2 dia-1 por meio de uma tela com 52% de sombreamento. As plantas foram cultivadas em sacolas, com 1,0 m entre fileiras e 0,3 m entre sacolas, enchidas com 5,5 L de substrato comercial. Nutrientes e água foram fornecidos via solução nutritiva, de forma a repor os volumes perdidos pela transpiração. Os tratamentos consistiram de uma (T1, duas (T2 e três (T3 plantas por sacola, correspondendo a densidades de 3,3; 6,7 e 10 plantas m-2, respectivamente. Em T1, três folhas por simpódio foram mantidas, com uma proporção de 3:1 entre o número de folhas e de inflorescências, em cada simpódio. Em T2, duas e uma folha foram mantidas respectivamente em dois simpódios consecutivos, alternativamente em ambas as plantas da sacola. A relação entre o número de folhas e de inflorescências foi de 3:2. Em T3, com três plantas por sacola, somente uma folha por simpódio foi mantida, com uma relação de 3:3. Em todos os experimentos, o número de inflorescências por unidade de área em T2 e T3 foi duas e três vezes maior que em T1, respectivamente. O número de frutos fixados por área de solo foi menor em T1 e similar em T2 e T3 no primeiro experimento, enquanto no segundo e terceiro experimentos valores similares foram observados entre os tratamentos. Os

  3. HDL: More Than Just Cholesterol

    Directory of Open Access Journals (Sweden)

    Anna Meilina

    2010-12-01

    Full Text Available BACKGROUND: Plasma concentration of high density lipoprotein cholesterol (HDL-C are strongly, consistenly, and independently inversely associated with risk of atheroschlerotic cardiovascular disease (CVD. However, the last decade has seen several observations that do not follow this simple script. CONTENT: A proteomic analysis of HDL has given us an intriguing glimpse into novel components of HDL. HDL isolated from normal humans contains several classes of proteins, including not only apolipoproteins, but also complement regulatory proteins, endopeptidase inhibitors, hemopexin, and acute phase response proteins. These observations raise the possibility of unsuspected roles for HDL. HDL delivery of complement proteins would implicate HDL in innate immunity. Serine proteinase inhibitors would enable HDL to modulate proteolysis of the vessel wall. HDL from patients with coronary artery disease was enriched in apoE, apoC-IV, apoA-IV, Paraoxonase (PON, and complement factor C3. Highlighted additional mechanisms through which HDL protects the vessel wall are: HDL improves vascular function, decreases vascular inflammation, detoxifies radicals, and limits thrombosis. SUMMARY: Both inter- and intra-organ desynchrony may be involved in the pathogenesis of cardiometabolic disease attributable to effects in brain and multiple metabolic tissues including heart, liver, fat, muscle, pancreas, and gut. Efforts to dissect the molecular mediators that coordinate circadian, metabolic, and cardiovascular systems may ultimately lead to both improved therapeutics and preventive interventions. KEYWORDS: HDL, Apo–A1, RCT, inflammation, HDL dysfunction, HDL proteome, HDL & Apo-A1 mimetics.

  4. Preparação e caracterização de biocompósitos baseados em fibra de curauá, biopolietileno de alta densidade (BPEAD e polibutadieno líquido hidroxilado (PBHL Preparation and characterization of biocomposites based on curaua fibers, high-density biopolyethylene (HDBPE and liquid hydroxylated polybutadiene(LHPB

    Directory of Open Access Journals (Sweden)

    Daniele O. Castro

    2013-01-01

    Full Text Available Neste trabalho, foram utilizadas fibras de curauá como reforço de matriz termoplástica de biopolietileno de alta densidade. O polietileno foi obtido por polimerização de eteno, gerado do etanol de cana de açúcar. Este polímero é também chamado de biopolietileno (BPEAD, por ser preparado a partir de material oriundo de fonte natural. Desta forma, pretendeu-se contribuir para desenvolver materiais que, dentre outras propriedades, causem menor emissão de CO2 para a atmosfera na sua produção, utilização e substituição, comparativamente a outros materiais. Adicionalmente, polibutadieno líquido hidroxilado (PBHL foi acrescentado à formulação do compósito, visando a um aumento na resistência à propagação da trinca durante impacto. Os compósitos e as fibras foram caracterizados por várias técnicas, tais como microscopia eletrônica de varredura (MEV, Calorimetria Exploratória Diferencial (DSC, Termogravimetria (TG, além da caracterização dos compósitos quanto à Análise Térmica Dinâmico-Mecânica (DMTA, propriedades mecânicas (impacto e flexão e absorção de água. A presença das fibras de curauá diminuiu algumas propriedades do BPEAD, como resistência ao impacto. A análise de DMTA mostrou que as fibras geram material mais rígido. Pode-se considerar que a introdução de PBHL na formulação do material foi eficiente, levando a uma resistência ao impacto do compósito BPEAD/PBHL/Fibra maior do que a do compósito BPEAD/Fibra.In this work, curaua fibers were used in the reinforcement of a high-density (HDPE thermoplastic matrix. The polyethylene used was obtained by polymerization of ethene produced from sugarcane ethanol. This polymer, also called high-density biopolyethylene (HDBPE, was prepared from a natural source material. The aim was to contribute to developing materials which could lead to smaller release of CO2 into the atmosphere in comparison to other materials. Additionally, liquid

  5. 75 FR 23263 - Alta Wind I, LLC; Alta Wind II, LLC; Alta Wind III, LLC; Alta Wind IV, LLC; Alta Wind V, LLC...

    Science.gov (United States)

    2010-05-03

    ... Energy Regulatory Commission Alta Wind I, LLC; Alta Wind II, LLC; Alta Wind III, LLC; Alta Wind IV, LLC; Alta Wind V, LLC; Alta Wind VI, LLC; Alta Wind VII, LLC; Alta Wind VIII, LLC; Alta Windpower... Federal Energy Regulatory Commission (Commission), 18 CFR 285.207 (2009), Alta Wind I, LLC, Alta Wind...

  6. Raising HDL cholesterol in women

    Directory of Open Access Journals (Sweden)

    Danny J Eapen

    2009-11-01

    Full Text Available Danny J Eapen1, Girish L Kalra1, Luay Rifai1, Christina A Eapen2, Nadya Merchant1, Bobby V Khan11Emory University School of Medicine, Atlanta, GA, USA; 2University of South Florida School of Medicine, Tampa, FL, USAAbstract: High-density lipoprotein cholesterol (HDL-C concentration is essential in the determination of coronary heart disease (CHD risk in women. This is especially true in the postmenopausal state, where lipid profiles and CHD risk mimic that of age-matched men. Thus, interventions designed to reduce CHD risk by raising HDL-C levels may have particular significance during the transition to menopause. This review discusses HDL-C-raising therapies and the role of HDL in the primary prevention of CHD in women. Lifestyle-based interventions such as dietary change, aerobic exercise regimens, and smoking cessation are initial steps that are effective in raising HDL-C, and available data suggest women respond similarly to men with these interventions. When combined with pharmacotherapy, the effects of these lifestyle alterations are further amplified. Though studies demonstrating gender-specific differences in therapy are limited, niacin continues to be the most effective agent in raising HDL-C levels, especially when used in combination with fibrate or statin therapy. Emerging treatments such as HDL mimetic therapy show much promise in further raising HDL-C levels and improving cardiovascular outcomes.Keywords: high-density lipoprotein, HDL, women, cholesterol, heart disease

  7. 77 FR 29633 - Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC...

    Science.gov (United States)

    2012-05-18

    ..., Alta Wind XII, LLC, Alta Wind XIII, LLC, Alta Wind XIV, LLC, Alta Wind XV, LLC, Alta Windpower... Windpower Development, LLC, and TGP Development Company, LLC (collectively, Petitioners), jointly...

  8. Efecto de la densidad en el crecimiento de juveniles tempranos de Cherax quadricarinatus (Decapoda: Parastacidae

    Directory of Open Access Journals (Sweden)

    M. C. Gallo-García

    2012-01-01

    Full Text Available En un estudio de cuatro semanas, se evaluó el efecto de tres densidades (134, 178, 223 org/ m2 sobre el crecimiento y supervivencia de juveniles tempranos (0.05 ± 0.02 g de Cherax quadricarinatus cultivados en un sistema de recirculación. Se alcanzaron pesos húmedos de 0.62 a 0.64 g, con tallas de 30.59 a 31.11 mm de longitud total y una supervivencia promedio final de 68%, sin diferencias significativas en los parámetros productivos de las diferentes densidades (p> 0.05. Los resultados sugieren la posibilidad de obtener buenos rendimientos durante el primer mes de cultivo a densidades tan altas como 223 org/m2 en un sistema de recirculación.

  9. Filamentos elásticos de elastolefina de alta durabilidad obtenidos a partir de copolímeros de bloque de etileno-octeno de baja densidad mediante la tecnología de polimerización por transferencia de cadena para aplicaciones en indumentaria de uso profesional

    OpenAIRE

    Verdú Blasco, Pau

    2010-01-01

    En la actualidad el mercado carece de prendas elásticas para uso profesional puesto que los elastanos habitualmente utilizados son inestables frente a altas temperaturas y químicos agresivos, e.g. termofijado, mantenimiento de indumentaria industrial etc. Recientemente se han venido utilizado filamentos olefínicos obtenidos a partir de copolímeros al azar de etileno-octeno (Dow XLA fibers producidos por The Dow Chemical Company). Aunque más resistentes a las temperaturas...

  10. MATÉRIA SECA E ABSORÇÃO DE NUTRIENTES EM FUNÇÃO DO ESPAÇAMENTO E DA DENSIDADE DE SEMEADURA EM ARROZ DE TERRA ALTA DRY MATTER AND NUTRIENT UPTAKE OF DRYLAND RICE RELATED TO ROW SPACING AND PLANT POPULATION

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    Carlos Alexandre Costa Crusciol

    1999-01-01

    Full Text Available Foi instalado um experimento em condições de campo, em um Latossolo Vermelho escuro, epi-eutrófico, textura argilosa, em Selvíria-MS, com arroz de sequeiro cv. IAC 201, estudando-se três espaçamentos entre fileiras (30, 40 e 50 cm e três densidades de semeadura (100, 150 e 200 sementes viáveis/m2. Foram avaliadas a produção de matéria seca da parte aérea no momento do florescimento e determinados os teores e quantidades de N, P, K, Ca, Mg e S absorvidos, assim como a eficiência de utilização de nutrientes. A redução do espaçamento entre fileiras aumentou a produção de matéria seca da parte aérea e a quantidade de nutrientes absorvidos. A variação da densidade de semeadura não afetou os parâmetros estudados. A redução do espaçamento entre fileiras proporcionou maior eficiência de utilização do Ca e diminuiu a do N e Mg. Os teores de nutrientes na matéria seca da parte aérea não foram afetados pela variação do espaçamento entre fileiras.A field experiment was conducted in a clayey Dark Red Latosol in Selviria, MS, Brazil, to study the effect of three row spacings (30, 40 and 50 cm and three seed densities (100, 150 and 200 viable seeds/m2 on plant dry matter yield, macronutrient (N, P, K, Ca, Mg and S uptake at flowering, and the nutrient use efficiency. A decrease in row spacing led to an increase in shoot dry matter production and nutrient uptake. There was no effect of plant densities on dry matter or nutrient uptake. The decrease in row spacing allowed a higher Ca use efficiency, but not for N and Mg. The concentration of the macronutrients in the shoots was not affected by spacing.

  11. urbana desde la densidad habitacional

    Directory of Open Access Journals (Sweden)

    Francisco Bascuñán Walker

    2007-01-01

    Full Text Available El objetivo del trabajo presentado fue reformular la relación de área construida y área verde Chilena según los estándares internacionales Europeos. Se estudio la mecánica actual de determinación de superficie de área verde en Chile y se comparó con los estándares españoles, elaborando una nueva formula que relaciona directamente la densidad habitacional con la superficie de área verde requerida. El estudio mostró que los resultados de superficies de área verde son de tal envergadura que requieren asociarse a parques comunales e intercomunales. Basados en los resultados del estudio se concluye que para cumplir con las superficies requeridas según la densidad habitacional los loteos nuevos deben contemplar su participación en proyectos de parques urbanos o comunales para garantizar el derecho de áreas verdes de los nuevos habitantes.

  12. Suplementação nutricional com antioxidantes naturais: efeito da rutina na concentração de colesterol-HDL

    Directory of Open Access Journals (Sweden)

    Rodrigues Hosana Gomes

    2003-01-01

    Full Text Available O estresse oxidativo está freqüentemente associado com alterações nas concentrações séricas de glicose e lipídios. O objetivo deste trabalho foi verificar se as alterações bioquímicas séricas, induzidas pela suplementação nutricional com o flavonóide rutina, estão associadas a propriedades antioxidantes. A administração de rutina (120mg/kg/semana, durante 15 dias, não induziu variação na glicemia de jejum e no teste de tolerância à glicose. Embora não tenham sido observadas mudanças significativas nas concentrações séricas de lipoperóxidos, triacilglicerois, colesterol-LDL e proteínas totais, a suplementação nutricional com rutina demonstrou importante papel na prevenção da aterosclerose, pois induziu elevação significativa da lipoproteína de alta densidade (colesterol-HDL de 35,82 ± 2,31mg/dL para 44,40 ± 3,11mg/dL. Como não foram observadas alterações na glutationa peroxidase, enquanto as atividades da superóxido dismutase foram elevadas pela ingestão de rutina. Pode-se concluir que os efeitos antioxidantes deste flavonoide, aumentando a concentração de colesterol-HDL, estão relacionados à elevação nas atividades da superóxido dismutase. A ação antioxidante da rutina pode estar relacionada à destruição do radical superóxido (O2-.

  13. Beyond HDL-cholesterol increase: phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers

    DEFF Research Database (Denmark)

    Schäfer, C.; Parlesak, Alexandr; Eckoldt, J.;

    2007-01-01

    The reduction of cardiovascular mortality associated with moderate alcohol consumption is chiefly thought to be mediated by an increase of high density lipoprotein cholesterol (HDL-CH). This study highlights additional qualitative changes of HDL that might augment this antiatherogenic effect...... HDL(2a), HDL(2b), and HDL(3). No difference in LDL-cholesterol was observed. Compared with group 1, groups 2 and 3 exhibited significant increases of HDL-CH (group 1, 44 +/- 10 mg/dl; group 2, 51 +/- 11 mg/dl; group 3, 55 +/- 11 mg/dl; mean +/- SD, P

  14. DENSIDADE DE SEMEADURA E PRODUTIVIDADE DO PORONGO

    Directory of Open Access Journals (Sweden)

    Dilson Antônio Bisognin

    1992-04-01

    Full Text Available O trabalho teve como objetivo determinar a melhor densidade de semeadura para a cultura do porongo Lagenaria siceraria (Mol. Standi. Foi realizado um experimento na Universidade Federal de Santa Maria -RS, em 1987-88, com densidades de 2.222; 2.500; 2.666; 3.333 e 4.444 covas/ha, sendo avaliada a produção de frutos industrializáveis (número de frutos/ha e número de frutos/cova. Em outro experimento, instalado em Restinga Seca-RS, em 1988-89, usou-se densidades de 1.111, 2.222, 3.333, 4.444, 5.555 e 6.666 covas/ha, sendo avaliadas a produção de frutos industrializáveis, número de nós na ramificação primária (nós/planta, espessura do casco e volume externo da cuia O delineamento experimental foi blocos ao acaso com quatro repetições e duas plantas por cova, nos dois experimentos. Os resultados de produtividade não mostraram relação com as diferentes densidades estudada?, mas os melhores resultados foram obtidos com densidades que variaram de 3.333 à 5.555 covas por hectare. O número de frutos/cova, nós/planta e a espessura do casco diminuíram à medida que aumentou a densidade de semeadura Em densidades menores a produtividade foi compensada pelo aumento do número de frutos por cova O aumento da densidade de semeadura diminuiu o volume externo da cuia.

  15. Altas capacidades e interdisciplinariedad

    OpenAIRE

    Moreno-García, María José

    2013-01-01

    El presente trabajo fin de grado trata de abordar la importancia de dar una respuesta educativa acorde a las necesidades del alumnado de altas capacidades. Para ello, primeramente, se ha visto necesario definir el término de altas capacidades, analizar sus características, matizar la importancia de su detección temprana, desbancar falsos mitos y conocer la legislación vigente al respecto, para posteriormente elaborar una propuesta de intervención, que se ha llevado a cabo en el Colegio Nelva,...

  16. Estonia's Alta buys Lauma lingerie

    Index Scriptorium Estoniae

    2004-01-01

    Eesti investeeringute firma Alta Capital ostis 76,4 protsenti pesutootja Lauma aktsiatest. Tulevikus plaanitakse suunduda Ida- ja Lääne-Euroopa turgudele. Alta Capital omab 79 protsenti Klementi aktsiatest

  17. Emerging therapeutic strategies to enhance HDL function

    Directory of Open Access Journals (Sweden)

    Urraca Concha

    2011-10-01

    Full Text Available Abstract Epidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL and cardiovascular disease (CVD. The most relevant cardioprotective mechanism mediated by HDL is thought to be reverse cholesterol transport (RCT. New insights in HDL biology and RCT have allowed the development of promising agents aimed to increase HDL function and promote atherosclerosis regression. In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD.

  18. Niacin Therapy, HDL Cholesterol, and Cardiovascular Disease: Is the HDL Hypothesis Defunct?

    Science.gov (United States)

    Mani, Preethi; Rohatgi, Anand

    2016-01-01

    High-density lipoprotein cholesterol (HDL-C) has been shown in epidemiologic studies to be associated with cardiovascular (CV) risk and thus significant efforts have been focused on HDL-C modulation. Multiple pharmaceutical agents have been developed with the goal of increasing HDL-C. Niacin, the most widely used medication to raise HDL-C, increases HDL-C by up to 25 % and was shown in multiple surrogate end point studies to reduce CV risk. However, two large randomized controlled trials of niacin, AIM-HIGH and HPS2-THRIVE, have shown that despite its effects on HDL-C, niacin does not decrease the incidence of CV events and may have significant adverse effects. Studies of other classes of agents such as cholesteryl ester transfer protein (CETP) inhibitors have also shown that even dramatic increases in HDL-C do not necessarily translate to reduction in clinical events. While these findings have cast doubt upon the importance of HDL-C modulation on CV risk, it is becoming increasingly clear that HDL function-related measures may be better targets for CV risk reduction. Increasing ApoA-I, the primary apolipoprotein associated with HDL, correlates with reduced risk of events, and HDL particle concentration (HDL-P) inversely associates with incident CV events adjusted for HDL-C and LDL particle measures. Cholesterol efflux, the mechanism by which macrophages in vessel walls secrete cholesterol outside cells, correlates with both surrogate end points and clinical events. The effects of niacin on these alternate measures of HDL have been conflicting. Further studies should determine if modulation of these HDL function markers translates to clinical benefits. Although the HDL cholesterol hypothesis may be defunct, the HDL function hypothesis is now poised to be rigorously tested. PMID:26048725

  19. Análisis del ciclo de vida del reciclado del polietileno de alta densidad

    OpenAIRE

    Garraín Cordero, Daniel; Vidal Nadal, María Rosario; Franco García, Vicente; Martínez Sebastiá, Pilar

    2008-01-01

    Thermoplastics make up roughly 80% of the plastics produced today. There are hundreds of types of them and new variations are being developed. But not all thermoplastics are recyclable in the same proportion. The most commonly recycled thermoplastics are polyethylene (PE), polypropylene (PP), polystyrene (PS) and polyvinyl chloride (PVC). In this study, real data from the industry is used in the analysis of the environmental impact of plastics recycling by means of the application of the ...

  20. HDL to verification logic translator

    Science.gov (United States)

    Gambles, J. W.; Windley, P. J.

    1992-01-01

    The increasingly higher number of transistors possible in VLSI circuits compounds the difficulty in insuring correct designs. As the number of possible test cases required to exhaustively simulate a circuit design explodes, a better method is required to confirm the absence of design faults. Formal verification methods provide a way to prove, using logic, that a circuit structure correctly implements its specification. Before verification is accepted by VLSI design engineers, the stand alone verification tools that are in use in the research community must be integrated with the CAD tools used by the designers. One problem facing the acceptance of formal verification into circuit design methodology is that the structural circuit descriptions used by the designers are not appropriate for verification work and those required for verification lack some of the features needed for design. We offer a solution to this dilemma: an automatic translation from the designers' HDL models into definitions for the higher-ordered logic (HOL) verification system. The translated definitions become the low level basis of circuit verification which in turn increases the designer's confidence in the correctness of higher level behavioral models.

  1. Uropatia Obstrutiva Alta

    OpenAIRE

    Campos Pinheiro, L; Matos Ferreira, A

    1999-01-01

    As lesões obstrutivas do aparelho urinário são muito frequentes. Apresenta-se uma revisão da etiologia e fisiopatologia da uropatia obstrutiva alta. Descreve-se pormenorizadamente a sua clínica e diagnóstico realçando-se os exames complementares mais adequados. Por fim apresentam-se as orientações terapêuticas e o prognóstico das diversas situações englobadas neste capítulo.

  2. de alta frecuencia

    Directory of Open Access Journals (Sweden)

    Juan Carlos Gáquez Abab

    2007-01-01

    Full Text Available Los mercados de consumo de alta frecuencia presentan rasgos particulares en cuanto a la diversidad de estrategias de precio, constantes promociones en precio, publicidad masiva o estrategias de marca que hacen que la identificación de segmentos sea especialmente interesante para la empresa. En el presente trabajo se lleva a cabo un análisis de segmentación sobre datos de panel que pretende identificar cuántos segmentos existen y describir cuál es su comportamiento en relación a variables como el precio o las promociones de ventas.

  3. High density lipoprotein (HDL) metabolism in noninsulin-dependent diabetes mellitus: measurement of HDL turnover using tritiated HDL

    Energy Technology Data Exchange (ETDEWEB)

    Golay, A.; Zech, L.; Shi, M.Z.; Chiou, Y.A.; Reaven, G.M.; Chen, Y.D.

    1987-09-01

    High density lipoprotein (HDL) kinetics were studied by injecting (/sup 3/H)apoprotein A-I (apoA-I)/HDL into 12 subjects with normal glucose tolerance and 12 patients with noninsulin-dependent diabetes mellitus (NIDDM). The results indicate that the mean fractional catabolic rate (FCR) of apoA-I/HDL was significantly faster (0.63 +/- 0.07 (+/- SEM) vs. 0.39 +/- 0.02 1/day; P less than 0.001) and the apoA-I/HDL synthetic rate greater (29.4 +/- 2.9 vs. 22.9 +/- 1.3 mg/kg X day; P less than 0.02) in patients with NIDDM than in normal subjects. Furthermore, there were statistically significant inverse relationships between apoA-I/HDL FCR and plasma levels of both HDL cholesterol (r = -0.71; P less than 0.001) and apoA-I (r = -0.63; P less than 0.001). In addition, the increase in apoA-I/HDL FCR was directly related to fasting plasma glucose (r = 0.78; P less than 0.001) and insulin (r = 0.76; P less than 0.001) concentrations. These data support the view that the decrease in plasma HDL cholesterol and apoA-I levels commonly found in patients with noninsulin-dependent diabetes is due to an increase in the catabolic rate of apoA-I/HDL secondary to the defects in carbohydrate metabolism present in these patients.

  4. Niacin Therapy, HDL Cholesterol, and Cardiovascular Disease: Is the HDL Hypothesis Defunct?

    OpenAIRE

    Mani, Preethi; Rohatgi, Anand

    2015-01-01

    High-density lipoprotein cholesterol (HDL-C) has been shown in epidemiologic studies to be associated with cardiovascular (CV) risk and thus significant efforts have been focused on HDL-C modulation. Multiple pharmaceutical agents have been developed with the goal of increasing HDL-C. Niacin, the most widely used medication to raise HDL-C, increases HDL-C by up to 25 % and was shown in multiple surrogate end point studies to reduce CV risk. However, two large randomized controlled trials of n...

  5. Pharmacological interventions in human HDL metabolism

    NARCIS (Netherlands)

    Balder, Jan-Willem; Staels, Bart; Kuivenhoven, Jan A.

    2013-01-01

    PURPOSE OF REVIEW: This review focuses on the recent developments in the field of drugs that affect HDL metabolism. Additionally, some general (retrospective) thoughts on fighting cardiovascular disease through modulating circulating lipids are discussed. RECENT FINDINGS: Recently, the large 'Athero

  6. Hinting en pantallas de alta resolución

    OpenAIRE

    Rodriguez, D

    2012-01-01

    Las pantallas de alta resolución no son algo nuevo —hay prototipos documentados ya en los años ochenta— pero al parecer ha llegado el momento de implantar esta tecnología: en junio de 2010 Steve Jobs presentó el iPhone 4 con la pantalla Retina como principal novedad: una superfície de 3,5 pulgadas con una densidad de 336 píxeles por pulgada. El ojo humano es incapaz de distinguir los píxeles en una imagen de esa resolución, por lo que el equipo directivo de Apple decidió bautizarla como Retin...

  7. Computer arithmetic and verilog HDL fundamentals

    CERN Document Server

    Cavanagh, Joseph

    2009-01-01

    Verilog Hardware Description Language (HDL) is the state-of-the-art method for designing digital and computer systems. Ideally suited to describe both combinational and clocked sequential arithmetic circuits, Verilog facilitates a clear relationship between the language syntax and the physical hardware. It provides a very easy-to-learn and practical means to model a digital system at many levels of abstraction. Computer Arithmetic and Verilog HDL Fundamentals details the steps needed to master computer arithmetic for fixed-point, decimal, and floating-point number representations for all prima

  8. Evaluación de los métodos directo, precipitado y Friedewald para la cuantificación de colesterol LDL y HDL en pollos de engorde

    Directory of Open Access Journals (Sweden)

    José Henry Osorio

    2012-12-01

    Full Text Available El objetivo fue evaluar los métodos directo y precipitado para el colesterol de las lipoproteínas de alta densidad y los métodos directo, precipitado y Friedewald para el colesterol de las lipoproteínas de baja densidad en pollos de engorde. Se obtuvo suero de 30 pollos de engorde de 36 días de edad, en ayunas, de la línea Cobb 500, se determinaron los niveles de triglicéridos y colesterol total usando un kit enzimático-colorimétrico. El colesterol, tanto de las lipoproteínas de alta densidad como de las de baja densidad, se midió por el método de precipitación y el método directo, y la estimación del colesterol de la lipoproteína de baja densidad se determinó usando la fórmula de Friedewald. Las medias ± desviación estándar para los niveles de colesterol de las lipoproteínas de alta densidad, por los métodos directo y precipitado, en mg/dl, fueron de: 92,8 ± 16,7; 92,2 ± 16,3, respectivamente. El valor P del test F es mayor a 0,05, por lo cual no hay diferencia estadísticamente significativa, con un índice de confianza de 95 % entre métodos, y para los niveles de colesterol de la lipoproteínas de baja densidad por los métodos directo, precipitado y Friedewald, en mg/dl, fueron: 51,8 ± 9,4; 21,9 ± 12,6 y 26,1 ± 12,9, respectivamente. El valor P del test F es inferior a 0,05 evidenciando diferencia estadísticamente significativa, con un índice de confianza de 95 % entre métodos. Se concluye que en los pollos de engorde se puede cuantificar el colesterol de la lipoproteína de alta densidad con los dos métodos evaluados (directo y precipitado, sin embargo, para calcular el colesterol de la lipoproteína de baja densidad solo se recomienda utilizar el método directo ya que los métodos de precipitado y de Friedewald dieron resultados mucho menores en dicha especie.

  9. HDL in sepsis - risk factor and therapeutic approach

    Directory of Open Access Journals (Sweden)

    Emily E Morin

    2015-10-01

    Full Text Available High-density lipoprotein (HDL is a key component of circulating blood and plays essential roles in regulation of vascular endothelial function and immunity. Clinical data demonstrate that HDL levels drop by 40-70% in septic patients, which is associated with a poor prognosis. Experimental studies using Apolipoprotein A-I (ApoAI null mice as an HDL deficient model showed that mice lacking HDL are susceptible to septic death, and overexpressing ApoAI in mice to increase HDL levels protects against septic death. These clinical and animal studies support our hypothesis that a decrease in HDL level is a risk factor for sepsis, and raising circulating HDL levels may provide an efficient therapy for sepsis. In this review, we discuss the roles of HDL in sepsis and summarize the efforts of using synthetic HDL as a potential therapy for sepsis.

  10. High pre-beta1 HDL concentrations and low lecithin: cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol

    DEFF Research Database (Denmark)

    Sethi, Amar A; Sampson, Maureen; Warnick, Russell;

    2010-01-01

    We hypothesized that patients with high HDL-cholesterol (HDL-C) and ischemic heart disease (IHD) may have dysfunctional HDL or unrecognized nonconventional risk factors.......We hypothesized that patients with high HDL-cholesterol (HDL-C) and ischemic heart disease (IHD) may have dysfunctional HDL or unrecognized nonconventional risk factors....

  11. HDL Cholesterol and Risk of Type 2 Diabetes

    DEFF Research Database (Denmark)

    Haase, Christiane L; Tybjærg-Hansen, Anne; Nordestgaard, Børge G;

    2015-01-01

    Observationally, low levels of HDL cholesterol are consistently associated with increased risk of type 2 diabetes. Therefore, plasma HDL cholesterol increasing has been suggested as a novel therapeutic option to reduce the risk of type 2 diabetes. Whether levels of HDL cholesterol are causally as...

  12. Friend Turns Foe: Transformation of Anti-Inflammatory HDL to Proinflammatory HDL during Acute-Phase Response

    Directory of Open Access Journals (Sweden)

    Hima Bindu G

    2011-01-01

    Full Text Available High-density lipoprotein (HDL is a major carrier of cholesterol in the blood. Unlike other lipoproteins, physiological functions of HDL influence the cardiovascular system in favorable ways except when HDL is modified pathologically. The cardioprotective mechanism of HDL is mainly based on reverse cholesterol transport, but there has been an emerging interest in the anti-inflammatory and antioxidant roles of HDL. These latter activities of HDL are compromised in many pathological states associated with inflammation. Further, abnormal HDL can become proinflammatory contributing to oxidative damage. In this paper, we discuss the functional heterogeneity of HDL, how alterations in these particles in inflammatory states result in loss of both antioxidant activity and reverse cholesterol transport in relation to atherosclerosis, and the need for assays to predict its functionality.

  13. Avaliação de diferentes densidades de semeadura e da poda na produtividade de sementes de Crotalaria juncea L.

    Directory of Open Access Journals (Sweden)

    Priscila Pixoline Eiras

    2012-10-01

    Full Text Available Verifica-se, atualmente, crescente interesse na prática de adubação verde e em seus efeitos nos sistemas produtivos agrícolas. Com o objetivo de avaliar diferentes densidades de semeadura e efeitos da poda na produção de sementes de Crotalaria juncea L., foi conduzido experimento na Unidade de Apoio à Pesquisa, na UENF, em Campos dos Goytacazes - RJ. O arranjo experimental foi em parcelas subdivididas, escolhendo-se como parcelas a presença e a ausência de poda e, como subparcelas, as densidades de semeio (10, 15, 20, 25 e 30 planta por metro. O delineamento foi em blocos casualizados, com quatro repetições. As unidades experimentais foram constituídas por seis linhas, com espaçamento de 0,5 m, com 4 metros de comprimento. Sem poda, a crotalária apresentou-se 0,634 m mais alta. O número de ramos de crotalária nas plantas podadas foi maior que o das não podadas e as densidades de 10 e 15 plantas ´por metro apresentaram maiores números de ramos. A densidade 30 apresentou maior quantidade de matéria seca. Com poda, a crotalária apresentou média de 7,2 vagens pequenas, enquanto, as plantas não podadas apresentaram média de 5,1 vagens pequenas. Quando se utilizou a densidade de 30 plantas por metro, ocorreram aproximadamente 25% a mais de sementes por vagem grande, nas plantas podadas, em relação às sementes das vagens grandes das plantas não podadas. Além disto, esta densidade apresentou maior número de sementes por vagem grande, em relação às das demais densidades. Recomenda-se a poda e a densidade de 10 plantas por metro, por menor gasto com sementes e sementes com maior vigor.

  14. La calidad de la densidad urbana en Bogotá

    Directory of Open Access Journals (Sweden)

    Óscar Alfonso Roa

    2016-06-01

    Full Text Available Para alojar a la creciente población de Bogotá, desde mediados del siglo pasado se prefiere aumentar la densidad en zonas residenciales que la expansión metropolitana. En este artículo se hace un análisis de la ocupación del perímetro bogotano que no se limita a los gradientes de densidad sino que integra medidas de su calidad que captan la desigualdad en materia de densidad, dotación pública, espacios libres y mezcla social. El índice resultante es una medida alternativa de la segregación socio-espacial.

  15. ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level

    Directory of Open Access Journals (Sweden)

    Kexiu Song

    2014-01-01

    Full Text Available HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved. Ectopic ATP synthase β-chain in hepatocytes has been previously characterized as an apoA-I receptor, triggering HDL internalization. This study was undertaken to identify the overexpression of ectopic ATP synthase β-chain on DIL-HDL uptake in primary hepatocytes in vitro and on plasma HDL levels in SR-BI knockout mice. Human ATP synthase β-chain cDNA was delivered to the mouse liver by adenovirus and GFP adenovirus as control. The adenovirus-mediated overexpression of β-chain was identified at both mRNA and protein levels on mice liver and validated by its increasing of DiL-HDL uptake in primary hepatocytes. In response to hepatic overexpression of β-chain, plasma HDL-C levels and cholesterol were reduced in SR-BI knockout mice, compared with the control. The present data suggest that ATP synthase β-chain can serve as the endocytic receptor of HDL, and its overexpression can reduce plasma HDL-C.

  16. Servidores web de altas prestaciones

    OpenAIRE

    Castillo Valdivieso, Pedro; Bernier Villamor, Jos?? Luis; Mora Garc??a, Antonio Miguel; Garc??a-S??nchez, Pablo; Garc??a Arenas, Mar??a Isabel

    2013-01-01

    Para crear un sitio web exitoso debemos ser cuidadosos con muchos detalles, ya que la arquitectura, la selecci??n del hardware, o la implementaci??n de las aplicaciones afectar??n al rendimiento del sistema completo. Es m??s, un sitio que no est?? preparado para dar servicio a un n??mero creciente de clientes o usuarios, a la larga puede llevar al fracaso a la empresa. En este trabajo, se presenta una visi??n general de la nueva asignatura Servidores Web de Altas Prestaciones, del nuevo plan...

  17. ApoE-containing HDL and the development of atherosclerosis

    Directory of Open Access Journals (Sweden)

    Zbigniew Zdrojewski

    2015-06-01

    Full Text Available The current state of knowledge about the role of high density lipoproteins (HDL indicates that their anti-atherogenic function is mainly related to the effectiveness of their actions (mostly to the participation in reverse cholesterol transport from tissues to liver rather than the concentration of HDL itself. HDLs are highly heterogeneous in their structure, lipid and protein composition and metabolic pathways and individual HDL subpopulations differ in their biological activity and effectiveness of anti-atherogenic actions. Apolipoproteins play a key role in HDL metabolism, therefore their presence in lipoproteins is one of the main criterion for HDL classification. According to this criterion HDLs containing apolipoprotein E, called HDL-apoE, are distinguished. Although the anti-atherogenic role of apo E has been demonstrated in many scientific reports, understanding of the mechanisms of formation, transformation and the role of HDL-apoE is still the aim of intense research. The results of epidemiological studies are inconclusive; some of them have demonstrated that high HDL- -apoE concentration has been associated with lower risk of developing coronary heart disease (CHD, while other studies have shown that high levels of HDL-apoE has been an independent risk factor for cardiovascular events and positively correlated with other risk factors for CHD.

  18. [HDL cholesterol as a sensitive diagnostic parameter in malaria].

    Science.gov (United States)

    Kittl, E M; Diridl, G; Lenhart, V; Neuwald, C; Tomasits, J; Pichler, H; Bauer, K

    1992-01-01

    In patients with malaria the lipid parameters triglycerides, cholesterol, and HDL-cholesterol were determined routinely. At the time of admission hypertriglyceridemia, hypocholesterolemia, and an extreme decrease in HDL-cholesterol were found. This dyslipoproteinemia was present in cases of falciparum malaria, as well as in cases of benign tertian malaria. The extent of HDL-cholesterol decrease showed no correlation to the severity of the clinical course of disease. HDL-cholesterol has proven to be an independent diagnostic laboratory finding in cases of suspected malarial infection. This parameter displays high diagnostic sensitivity, but no specificity for malaria. PMID:1546481

  19. La densidad urbana como variable de análisis de la ciudad: El caso de Cuenca, Ecuador

    Directory of Open Access Journals (Sweden)

    M. Augusta Hermida

    2015-09-01

    Full Text Available El debate teórico sobre la ciudad dispersa versus la ciudad compacta, en el mundo y particularmente en América Latina, pone en la palestra los aspectos clave necesarios para proponer un nuevo modelo de ciudad, donde la calidad de vida de las presentes y futuras generaciones sea el punto focal de reflexión. A través del estudio del estado del arte sobre el tema se concluye que el regreso a la ciudad compacta es la alternativa para un posible desarrollo sustentable en las ciudades intermedias de América Latina. En el caso de Cuenca, se concentra el estudio en las densidades de la ciudad desde los años cincuenta hasta nuestros días. Sorprende comprobar que Cuenca fue una ciudad compacta con alta calidad de vida pero que, paulatinamente, se está expandiendo innecesariamente, con todos los problemas que ello implica.

  20. Endothelial lipase is a major determinant of HDL level

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, Tatsuro; Choi, Sungshin; Kundu, Ramendra K.; Hirata, Ken-Ichi; Rubin, Edward M.; Cooper, Allen D.; Quertermous, Thomas

    2003-01-30

    For the past three decades, epidemiologic studies have consistently demonstrated an inverse relationship between plasma HDL cholesterol (HDL-C) concentrations and coronary heart disease (CHD). Population-based studies have provided compelling evidence that low HDL-C levels are a risk factor for CHD, and several clinical interventions that increased plasma levels of HDL-C were associated with a reduction in CHD risk. These findings have stimulated extensive investigation into the determinants of plasma HDL-C levels. Turnover studies using radiolabeled apolipoprotein A-I, the major protein component of HDL, suggest that plasma HDL-C concentrations are highly correlated with the rate of clearance of apolipoprotein AI. However, the metabolic mechanisms by which HDL are catabolized have not been fully defined. Previous studies in humans with genetic deficiency of cholesteryl ester transfer protein, and in mice lacking the scavenger receptor BI (SR-BI), have demonstrated that these proteins participate in the removal of cholesterol from HDL, while observations in individuals with mutations in hepatic lipase indicate that this enzyme hydrolyzes HDL triglycerides. In this issue of the JCI, reports from laboratories of Tom Quertermous and Dan Rader now indicate that endothelial lipase (LIPG), a newly identified member of the lipase family, catalyzes the hydrolysis of HDL phospholipids and facilitates the clearance of HDL from the circulation. Endothelial lipase was initially cloned by both of these laboratories using entirely different strategies. Quertermous and his colleagues identified endothelial lipase as a transcript that was upregulated in cultured human umbilical vein endothelial cells undergoing tube formation, whereas the Rader group cloned endothelial lipase as a transcript that was upregulated in the human macrophage-like cell line THP-1 exposed to oxidized LDL. Database searches revealed that endothelial lipase shows strong sequence similarity to lipoprotein

  1. Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo

    OpenAIRE

    Sacks, Frank M.; Rudel, Lawrence L.; Conner, Adam; Akeefe, Hassibullah; Kostner, Gerhard; Baki, Talal; Rothblat, George; de la Llera-Moya, Margarita; Asztalos, Bela; Perlman, Timothy; Zheng, Chunyu; Alaupovic, Petar; Maltais, Jo-Ann B.; Brewer, H. Bryan

    2009-01-01

    Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that transfers its cholesterol to the liver facilitating excretion. Most HDL in plasma is cholesterol-rich. We demonstrate that treating plasma with a novel selective delipidation procedure converts large to small HDL [HDL-selectively delipidated (HDL-sdl)]. HDL-sdl contains seve...

  2. TransAlta: More than a utility

    International Nuclear Information System (INIS)

    TransAlta Utilities Corporation is Canada's largest privately owned utility and is also a major coal mining company. In 1989, TransAlta produced 20.9% of all coal mined in Canada. A brief history of TransAlta is presented along with TransAlta's present coal operations and plans for the next three years. An overview is presented of how TransAlta Fuel Supply is organized to utilize contracted mining operation, engineering and environmental services and in-house capabilities. Recent strategic initiatives to improve organizational efficiency and the mining operations are discussed. These range from developing a common departmental vision to modifying major mining equipment. TransAlta's proactive role in clean coal combustion such as low NOx-SOx burner, integrated combined cycle gasification, and other energy research projects is reviewed. A summary is provided of recent participation of TransAlta in environmental management initiatives. Recent successes of TransAlta's unregulated subsidiary in the development of cogeneration facilities and the future of this area of business are discussed. 8 refs., 4 figs

  3. Alta peab tasuma Kalevile mais / Kersti Saar

    Index Scriptorium Estoniae

    Saar, Kersti

    2008-01-01

    Indrek Rahumaa juhitav Alta Capital peab tasuma Oliver Kruudale Kalevi tütarfirmade eest 660 miljonit krooni hiljemalt 30. maiks. Vt. samas: Investorid teavad tehingu hinda ja lõplikku tähtaega. Diagramm: Kalevi turuväärtus jääb Alta müügihinnale alla

  4. Evaluation of triglyceride: HDL-C ratio and Non-HDL-C as harbingers of increased cardiovascular risk in metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Dharuni R.

    2016-09-01

    Conclusions: This study demonstrated that TG/HDL-C ratio and Non HDL-C are strongly associated with metabolic syndrome in urban population. In comparison, TG/HDL-C is a better predictor of metabolic syndrome than non-HDL-C. [Int J Res Med Sci 2016; 4(9.000: 4050-4054

  5. Whey protein improves HDL/non-HDL ratio and body weight gain in rats subjected to the resistance exercise

    Directory of Open Access Journals (Sweden)

    Kely Raspante Teixeira

    2012-12-01

    Full Text Available The aim of this study was to evaluate the effects of resistance exercise, such as weight-lifting (WL on the biochemical parameters of lipid metabolism and cardiovascular disease risk in the rats fed casein (control or whey protein (WP diets. Thirty-two male Fisher rats were randomly assigned to sedentary or exercise-trained groups and were fed control or WP diets. The WL program consisted of inducing the animals to perform the sets of jumps with weights attached to the chest. After seven weeks, arteriovenous blood samples were collected for analysis. The WL or WP ingestion were able to improve the lipid profile, reducing the TC and non-HDL cholesterol concentrations, but only WP treatment significantly increased the serum HDL concentrations, thereby also affecting the TC/HDL and HDL/non-HDL ratios. However, WL plus WP was more effective in improving the HDL/non-HDL ratio than the exercise or WP ingestion alone and the body weight gain than exercise without WP ingestion.

  6. LCAT, HDL Cholesterol and Ischemic Cardiovascular Disease: A Mendelian Randomization Study of HDL Cholesterol in 54,500 Individuals

    DEFF Research Database (Denmark)

    Haase, Christiane L; Tybjærg-Hansen, Anne; Ali Qayyum, Abbas;

    2012-01-01

    Background:Epidemiologically, high-density lipoprotein (HDL) cholesterol levels associate inversely with risk of ischemic cardiovascular disease. Whether this is a causal relation is unclear.Methods:We studied 10,281 participants in the Copenhagen City Heart Study (CCHS) and 50,523 participants...... in the Copenhagen General Population Study (CGPS), of which 991 and 1,693 participants, respectively, had developed myocardial infarction (MI) by August 2010. Participants in the CCHS were genotyped for all six variants identified by resequencing lecithin-cholesterol acyltransferase in 380 individuals. One variant......, S208T (rs4986970, allele frequency 4%), associated with HDL cholesterol levels in both the CCHS and the CGPS was used to study causality of HDL cholesterol using instrumental variable analysis.Results:Epidemiologically, in the CCHS, a 13% (0.21 mmol/liter) decrease in plasma HDL cholesterol levels...

  7. STUDIES ON THE HDL RECEPTORS I:EVIDENCE FOR THE EXISTENCE OF HDL RECEPTORS IN BEIJING DUCK LIVER

    Institute of Scientific and Technical Information of China (English)

    武须军; 王克勤

    1994-01-01

    It hab been found that Beijing ducks (BD)have a high level of HDL(70%),high LCAT but very low CETP activity and will not develop atheroscletosis on an atherogenic diet,suggesting that cholesterol ester is mainly carried by HDL and metabolized through an HDL receptor pathway in the liver.However,evidence of this recep-tor′s existence in the liver is not yet complete.In this paper,the HDL receptor in BD liver has been studied.Our experiments showed:1)ApoE-free 125I-HDL could bind specifically to duck hepatic cell membrane with high affinity (Kd=9.6 μg/ml)and was saturable(Bmax=8.9μg/mg cell membrane protein)at room temperature.2)Competitive inhibition studies with unlabelled duck,human,rat and chick HDL and duck apo AI and its lipo-somes formed with PC or DMPC could inhibit the binding of 125I-HDL to duck hepatic cell membranes,but LDL,apo Eand their liposomes with PC or DMPC could not with the exception of duck LDL.3)The receptor could rec-ognize apo AI but not apo B or E.4)Both phosphorase A2 and pronase could inhibit the binding activity.The above results give strong evidence for the existence of a specific HLD receptor pathway in the duck liver,support-ing our hypothesis that CE in Beijing ducks is metabolized directly through the hepatic HDL receptor instead of be-ing transfered back to VLDL and LDL,then through the LDL receptor pathway.This unique way of metabolizing CE may be behind the Beijing duck′s antiatherogenicity.

  8. Development of a high density fuel based on uranium-molybdenum alloys with high compatibility in high temperatures; Desenvolvimento de um combustivel de alta densidade a base das ligas uranio-molibdenio com alta compatibilidade em altas temperaturas

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Fabio Branco Vaz de

    2008-07-01

    This work has as its objective the development of a high density and low enriched nuclear fuel based on the gamma-UMo alloys, for utilization where it is necessary satisfactory behavior in high temperatures, considering its utilization as dispersion. For its accomplishment, it was started from the analysis of the RERTR ('Reduced Enrichment for Research and Test Reactors') results and some theoretical works involving the fabrication of gamma-uranium metastable alloys. A ternary addition is proposed, supported by the properties of binary and ternary uranium alloys studied, having the objectives of the gamma stability enhancement and an ease to its powder fabrication. Alloys of uranium-molybdenum were prepared with 5 to 10% Mo addition, and 1 and 3% of ternary, over a gamma U7Mo binary base alloy. In all the steps of its preparation, the alloys were characterized with the traditional techniques, to the determination of its mechanical and structural properties. To provide a process for the alloys powder obtention, its behavior under hydrogen atmosphere were studied, in thermo analyser-thermo gravimeter equipment. Temperatures varied from the ambient up to 1000 deg C, and times from 15 minutes to 16 hours. The results validation were made in a semi-pilot scale, where 10 to 50 g of powders of some of the alloys studied were prepared, under static hydrogen atmosphere. Compatibility studies were conducted by the exposure of the alloys under oxygen and aluminum, to the verification of possible reactions by means of differential thermal analysis. The alloys were exposed to a constant heat up to 1000 deg C, and their performances were evaluated in terms of their reaction resistance. On the basis of the results, it was observed that ternary additions increases the temperatures of the reaction with aluminum and oxidation, in comparison with the gamma UMo binaries. A set of conditions to the hydration of the alloys were defined, more restrictive in terms of temperature, time and pre-treatment to stabilize the gamma structure. The addition of a bit low ternary excess and formation of an intergranular phase, the increase in stability, it was demonstrated that there is not a damage in the formation of their powders.(author)

  9. Riqueza e densidade de aves que nidificam em cavidades em plantações abandonadas de eucalipto

    Directory of Open Access Journals (Sweden)

    Hugo de Siqueira Pereira

    2015-05-01

    Full Text Available Monoculturas de árvores, como as de espécies de eucalipto, têm substituído florestas naturais, impactando a fauna pela perda de habitat e recursos. Diversas espécies de aves necessitam de ocos em árvores para nidificar. A falta de recursos como cavidades formadas pela degradação da árvore ou locais apropriados para serem criadas cavidades leva a diminuição na abundância das populações destas espécies. Este trabalho tem o objetivo de comparar a riqueza e a densidade de aves que nidificam em ocos em áreas de plantação de eucalipto abandonadas com áreas de vegetação nativa em duas unidades de conservação em Minas Gerais. Em cada tipo de vegetação de cada reserva foram estabelecidos 25 pontos, nas quais foi utilizado o método de contagem por remoção para o levantamento das espécies de aves. A riqueza de espécies de aves de cada área foi estimada por Jackniffe e a densidade foi estimada através do método de máxima verossimilhança; modelos candidatos que poderiam influenciar a abundância das aves foram avaliados utilizando-se o Critério de Informação Akaike (AIC. Os resultados mostraram que a riqueza de espécies foi maior nas áreas de florestas nativas e que a densidade foi significantemente mais alta nas áreas de florestas nativas, e que o tipo de vegetação e a hora do dia influenciam na abundância e detecção das aves. Esses resultados indicam que as plantações de eucaliptos influenciam negativamente a comunidade de aves que nidificam em ocos, provavelmente por causa da falta de cavidades ou de sub-bosque. Plantações de eucaliptos normalmente não substituem as florestas nativas e seu uso deve ser controlado em áreas de conservação.

  10. Modular hardware synthesis using an HDL. [Hardware Description Language

    Science.gov (United States)

    Covington, J. A.; Shiva, S. G.

    1981-01-01

    Although hardware description languages (HDL) are becoming more and more necessary to automated design systems, their application is complicated due to the difficulty in translating the HDL description into an implementable format, nonfamiliarity of hardware designers with high-level language programming, nonuniform design methodologies and the time and costs involved in transfering HDL design software. Digital design language (DDL) suffers from all of the above problems and in addition can only by synthesized on a complete system and not on its subparts, making it unsuitable for synthesis using standard modules or prefabricated chips such as those required in LSI or VLSI circuits. The present paper presents a method by which the DDL translator can be made to generate modular equations that will allow the system to be synthesized as an interconnection of lower-level modules. The method involves the introduction of a new language construct called a Module which provides for the separate translation of all equations bounded by it.

  11. HIFSuite: Tools for HDL Code Conversion and Manipulation

    Directory of Open Access Journals (Sweden)

    Bombieri Nicola

    2010-01-01

    Full Text Available Abstract HIFSuite ia a set of tools and application programming interfaces (APIs that provide support for modeling and verification of HW/SW systems. The core of HIFSuite is the HDL Intermediate Format (HIF language upon which a set of front-end and back-end tools have been developed to allow the conversion of HDL code into HIF code and vice versa. HIFSuite allows designers to manipulate and integrate heterogeneous components implemented by using different hardware description languages (HDLs. Moreover, HIFSuite includes tools, which rely on HIF APIs, for manipulating HIF descriptions in order to support code abstraction/refinement and postrefinement verification.

  12. Bile Acids Reduce Endocytosis of High-Density Lipoprotein (HDL) in HepG2 Cells

    OpenAIRE

    Clemens Röhrl; Karin Eigner; Stefanie Fruhwürth; Herbert Stangl

    2014-01-01

    High-density lipoprotein (HDL) transports lipids to hepatic cells and the majority of HDL-associated cholesterol is destined for biliary excretion. Cholesterol is excreted into the bile directly or after conversion to bile acids, which are also present in the plasma as they are effectively reabsorbed through the enterohepatic cycle. Here, we provide evidence that bile acids affect HDL endocytosis. Using fluorescent and radiolabeled HDL, we show that HDL endocytosis was reduced in the presence...

  13. HDL2-C和HDL3-C与老年男性冠心病发病相关性分析%Correlation analysis of high-density lipoprotein subfractions(HDL2,HDL3)and coronary heart disease in the male elderly

    Institute of Scientific and Technical Information of China (English)

    赵勇; 任红旗; 史跃; 项军

    2012-01-01

    目的 探讨高密度脂蛋白胆固醇亚组分(HDL2-C和HDL3-C)与老年男性冠心病发病相关性.方法 随机选择老年男性冠心病60例,无冠心病老年男性60例为对照组.应用硫酸葡聚糖-镁法测定HDL-C亚组分HDL2-C和HDL3-C,并分析其与冠心病发生的相关性.结果 与对照组相比,老年男性冠心病组HDL-C和HDL3-C均显著下降(P均0.05).Logistic回归分析显示HDL3-C、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)及高血压病作为老年男性冠心病发病的独立危险因子进入回归方程,HDL-C和HDL2-C未进入方程.Spearman秩相关分析显示HDL3-C与冠心病发病的负相关性(r=-0.310,P=0.030)优于HDL-C(r=-0.154,P=0.274)和HDL2-C(r=-0.014,P=0.924).结论 HDL3-C与老年男性冠心病发病的负相关性优于HDL-C和HDL2-C,HDL3-C是老年男性冠心病发生的独立危险因子,HDL-C抗冠状动脉粥样硬化作用可能主要是通过HDL3-C实现的.%Objective To evaluate whether one or both of the major high-density lipoprotein ( HDL) subfractions ( HDL2, HDL3 ) is associated with the risk of coronary heart disease ( CHD ) in the male elderly. Methods Sixty people with CHD were randomly selected as group A and 60 people without CHD as the control , all the examinations were the male elderly. The separation of HDL subfractions was carried out by dextran sulfate -magnesium chloride technique , and the correlation between HDL subfractions ( HDL2, HDL3 ) and coronary heart disease were analyzed. Results The group A had significantly lower HDL and HDL 3 cholesterol levels compared to the control ( both P < 0. 01 ) , while HDL2 cholesterol levels was not significantly reduced . The Spearman rank correlation analysis indicated that CHD significantly correlated with HDL 3 cholesterol (r = - 0. 310 , P = 0. 030 ) , but not with HDL cholesterol ( r = - 0. 154, P = 0. 274 ) and HDL2 cholesterol ( r = - 0. 014 , P = 0. 924 ). Logistic regression analysis revealed that HDL3

  14. Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo.

    Science.gov (United States)

    Sacks, Frank M; Rudel, Lawrence L; Conner, Adam; Akeefe, Hassibullah; Kostner, Gerhard; Baki, Talal; Rothblat, George; de la Llera-Moya, Margarita; Asztalos, Bela; Perlman, Timothy; Zheng, Chunyu; Alaupovic, Petar; Maltais, Jo-Ann B; Brewer, H Bryan

    2009-05-01

    Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that transfers its cholesterol to the liver facilitating excretion. Most HDL in plasma is cholesterol-rich. We demonstrate that treating plasma with a novel selective delipidation procedure converts large to small HDL [HDL-selectively delipidated (HDL-sdl)]. HDL-sdl contains several cholesterol-depleted species resembling small alpha, prebeta-1, and other prebeta forms. Selective delipidation markedly increases efficacy of plasma to stimulate ABCA1-mediated cholesterol transfer from monocytic cells to HDL. Plasma from African Green monkeys underwent selective HDL delipidation. The delipidated plasma was reinfused into five monkeys. Prebeta-1-like HDL had a plasma residence time of 8 +/- 6 h and was converted entirely to large alpha-HDL having residence times of 13-14 h. Small alpha-HDL was converted entirely to large alpha-HDL. These findings suggest that selective HDL delipidation activates reverse cholesterol transport, in vivo and in vitro. Treatment with delipidated plasma tended to reduce diet-induced aortic atherosclerosis in monkeys measured by intravascular ultrasound. These findings link the conversion of small to large HDL, in vivo, to improvement in atherosclerosis. PMID:19144994

  15. Inflammation reduces HDL protection against primary cardiac risk

    NARCIS (Netherlands)

    Corsetti, James P.; Gansevoort, Ron T.; Sparks, Charles E.; Dullaart, Robin P. F.

    2010-01-01

    P>Background We recently reported high high-density lipoprotein (HDL) cholesterol as a predictor of recurrent risk in a subgroup of postinfarction patients defined by hypercholesterolemia and high C-reactive protein (CRP) levels. We investigated whether a similar high-risk subgroup might exist for i

  16. Design Time Optimization for Hardware Watermarking Protection of HDL Designs

    Directory of Open Access Journals (Sweden)

    E. Castillo

    2015-01-01

    Full Text Available HDL-level design offers important advantages for the application of watermarking to IP cores, but its complexity also requires tools automating these watermarking algorithms. A new tool for signature distribution through combinational logic is proposed in this work. IPP@HDL, a previously proposed high-level watermarking technique, has been employed for evaluating the tool. IPP@HDL relies on spreading the bits of a digital signature at the HDL design level using combinational logic included within the original system. The development of this new tool for the signature distribution has not only extended and eased the applicability of this IPP technique, but it has also improved the signature hosting process itself. Three algorithms were studied in order to develop this automated tool. The selection of a cost function determines the best hosting solutions in terms of area and performance penalties on the IP core to protect. An 1D-DWT core and MD5 and SHA1 digital signatures were used in order to illustrate the benefits of the new tool and its optimization related to the extraction logic resources. Among the proposed algorithms, the alternative based on simulated annealing reduces the additional resources while maintaining an acceptable computation time and also saving designer effort and time.

  17. Design time optimization for hardware watermarking protection of HDL designs.

    Science.gov (United States)

    Castillo, E; Morales, D P; García, A; Parrilla, L; Todorovich, E; Meyer-Baese, U

    2015-01-01

    HDL-level design offers important advantages for the application of watermarking to IP cores, but its complexity also requires tools automating these watermarking algorithms. A new tool for signature distribution through combinational logic is proposed in this work. IPP@HDL, a previously proposed high-level watermarking technique, has been employed for evaluating the tool. IPP@HDL relies on spreading the bits of a digital signature at the HDL design level using combinational logic included within the original system. The development of this new tool for the signature distribution has not only extended and eased the applicability of this IPP technique, but it has also improved the signature hosting process itself. Three algorithms were studied in order to develop this automated tool. The selection of a cost function determines the best hosting solutions in terms of area and performance penalties on the IP core to protect. An 1D-DWT core and MD5 and SHA1 digital signatures were used in order to illustrate the benefits of the new tool and its optimization related to the extraction logic resources. Among the proposed algorithms, the alternative based on simulated annealing reduces the additional resources while maintaining an acceptable computation time and also saving designer effort and time.

  18. Plasma HDL cholesterol and risk of myocardial infarction

    DEFF Research Database (Denmark)

    Voight, Benjamin F; Peloso, Gina M; Orho-Melander, Marju;

    2012-01-01

    High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendel...

  19. Design time optimization for hardware watermarking protection of HDL designs.

    Science.gov (United States)

    Castillo, E; Morales, D P; García, A; Parrilla, L; Todorovich, E; Meyer-Baese, U

    2015-01-01

    HDL-level design offers important advantages for the application of watermarking to IP cores, but its complexity also requires tools automating these watermarking algorithms. A new tool for signature distribution through combinational logic is proposed in this work. IPP@HDL, a previously proposed high-level watermarking technique, has been employed for evaluating the tool. IPP@HDL relies on spreading the bits of a digital signature at the HDL design level using combinational logic included within the original system. The development of this new tool for the signature distribution has not only extended and eased the applicability of this IPP technique, but it has also improved the signature hosting process itself. Three algorithms were studied in order to develop this automated tool. The selection of a cost function determines the best hosting solutions in terms of area and performance penalties on the IP core to protect. An 1D-DWT core and MD5 and SHA1 digital signatures were used in order to illustrate the benefits of the new tool and its optimization related to the extraction logic resources. Among the proposed algorithms, the alternative based on simulated annealing reduces the additional resources while maintaining an acceptable computation time and also saving designer effort and time. PMID:25861681

  20. Alta Capital investeerib miljardeid kroone / Raigo Neudorf

    Index Scriptorium Estoniae

    Neudorf, Raigo

    2006-01-01

    Investeerimisfirma Alta Capital nõukogu esimees Indrek Rahumaa annab ülevaate sellest, kuidas ettevõte on lühikese ajaga suutnud omandada osaluse mitmetes ettevõtetes ning suunanud neisse investeeringuid 150 miljoni euro väärtuses. Vt. samas: Osalused; Omanikud

  1. Relation of Oxidative Stress and Impaired Fibrinolysis with HDL Biogenesis in Indonesian Men with Metabolic Syndrome

    Directory of Open Access Journals (Sweden)

    Ida Paulina Sormin

    2010-04-01

    Full Text Available BACKGROUND: Biogenesis of HDL involves factors that regulate the synthesis, intravascular remodeling, and catabolism of HDL. Disturbance of these factors can lead to low concentration of HDL-C. Metabolic syndrome (MetS is characterized by low concentration of high-density lipoprotein cholesterol (HDL-C. In MetS occur several pathological conditions including oxidative stress and impaired fibrinolysis, which contribute to the risk of atherosclerosis process. The correlation between oxidative stress and impaired fibrinolysis with HDL biogenesis dysfunction and its correlation with low concentration of HDL-C has not been well understood and therefore needs to be further investigated. METHODS: This study was an observational study with crosssectional design, involving 163 adult men, aged 25-60 years with metabolic syndrome. Concentration of apoA-1, prebeta-1 HDL, CETP, F2-isoprostan, PAI-1, and HDL-C were measured. The apo A1/HDL ratio indicated HDL maturation, whereas the CETP/HDL-C and CETP/TG ratios indicated HDL catabolism. RESULTS: The study showed that there were a positive correlation between PAI-1 with apoA1/HDL-C ratios (r=0.226, p=0.005 and a negative correlation with the CETP/TG ratios (r=-0.215, p=0.007, whereas F2-isoprostan did not have correlation with HDL biogenesis factors. CONCLUSIONS: We concluded that there was correlation between impaired fibrinolysis with decreased HDL maturation and there was increased HDL catabolism leading to low HDL-C concentration in men with metabolic syndrome. KEYWORDS: F2-isoprostan, PAI-1, apoA-1, prebeta-1 HDL, CETP, metabolic syndrome.

  2. y alta de la subcuenca Cohatán, Chiapas

    Directory of Open Access Journals (Sweden)

    M. Grajales

    2008-01-01

    Full Text Available El estudio consistió en un diagnóstico biofísico (fisiográfico, hidrográfico, uso actual del suelo, cobertura vegetal y socioeconómico (infraestructura social y productiva con actividades en la subcuenca Cohatán, localizado en las estribaciones de la Sierra del Soconusco Chiapas, para saber la situación que guarda y generar acciones de rehabilitación, a mediano y largo plazo. Esta subcuenca se extiende desde 350 a los 4,080 msnm, con 42 comunidades, que abarcan los municipios de Tapachula, Motozintla y Cacahotán, Chiapas; tiene una densidad de 1.2 hab/ha, con suelo de origen volcánico formado del Cenozoico terciario de unidad acrisol húmico. El 80% de la superficie presenta clima tropical húmedo y subhúmedo, con relieve de ladera fuerte hasta de 60%, con una erosión hídrica severa de 250 t/ ha/año en 42% de la superficie; tiene 25% de selva, medias altas y perennifolias. La principal actividad económica es la explotación del cultivo de café, desde el área marginal 350 hasta 2,660 msnm. A lo largo del río Cohatán el tipo de desarrollo se sustenta en el uso intensivo de los recursos naturales, originan —a su vez— fuerte deterioro neceambiental, al cambio de vegetación de la selva original por introducción de especies de sombra del café con chalum (Inga spp; en este ecosistema se observa un deficiente uso de tecnología de producción que se refleja en el bajo rendimiento del café, de 8 quintales/ha. El nivel socioeconómico de desarrollo es bajo, con nivel de educación, salud, vivienda y servicios deficientes, así como falta de apoyo social, con carente gestión ambiental

  3. HDL Implementation of Low Density Parity Check (LDPC Decoder

    Directory of Open Access Journals (Sweden)

    Pawandip Kaur

    2012-03-01

    Full Text Available Low-Density Parity-Check (LDPC codes are one of the most promising error-correcting codes approaching Shannon capacity and have been adopted in many applications. These codes offer huge advantages in terms of coding gain, throughput and power dissipation. Error correction algorithms are often implemented in hardware for fast processing to meet the real-time needs of communication systems. However hardwareimplementation of LDPC decoders using traditional Hardware Description Language (HDL based approach is a complex and time consuming task. In this paper HDL Implementation of Low Density Parity Check Decoder architecture is presented with different rates i.e. 1/2, 2/3, 3/4, 4/7, 8/9, 9/10 and variable data lengths i.e. 8, 16, 32, 64, 128, 256 bits and consequent changeable precision factor.

  4. The Inverse Relation of HDL Anti-Oxidative Functionality with Serum Amyloid a is Lost in Metabolic Syndrome Subjects

    NARCIS (Netherlands)

    Dullaart, Robin P. F.; de Boer, Jan Freark; Annema, Wijtske; Tietge, Uwe J. F.

    2013-01-01

    Objective: Anti-oxidative properties of high density lipoproteins (HDL) are relevant for atheroprotection. HDL carry serum amyloid A (SAA), which may impair HDL functionality. We questioned whether HDL anti-oxidative capacity is determined by SAA. Design and Methods: Relationships of HDL anti-oxidat

  5. Diffusione molecolare neLl' alta atmosfera

    Directory of Open Access Journals (Sweden)

    C. ARDUINI

    1963-06-01

    Full Text Available Le perturbazioni indotte nell'alta atmosfera dall'emissione,
    a mezzo di razzi sonda, di nubi di vapori estranei sono un utile
    mezzo per lo studio simultaneo di alcune caratteristiche fisiche e dinamiche
    degli alti strati.
    La presente relazione illustra in breve i principi di alcune tecniche
    per la misura del coefficiente di diffusione binaria tra l'aria e il vapore
    della nube artificiale.

  6. TransAlta 2003 annual report

    International Nuclear Information System (INIS)

    This annual report presents financial information from TransAlta Corp., along with a review of its operations throughout 2003 and a summary of the how the electric utility has performed in terms of power generation, independent power producers, transmission and energy marketing. TransAlta is one of the largest non-regulated power generation and wholesale marketing companies in Canada. It's assets include coal-fired, gas-fired, hydro and renewable generation facilities in Canada, the United States, Mexico and Australia. Reported earnings in 2003 were $1.26 per share compared to $1.17 in 2002. The strong first quarter was followed by harsh market conditions, low water levels which affected hydro production, and pricing restrictions in Ontario that reduced contribution from the Sarnia plant. This report outlines the utility's progress in increasing revenue and producing more power. In 2003, unplanned outages were reduced by 7 per cent and injury frequency rate was reduced by 27 per cent. The installation of 114 wind turbines in Fort Macleod, Alberta, increased TransAlta's renewable energy capacity to 3.7 per cent in 2003. The wind farm produces 75 MW of electricity, enough to power more than 32,500 homes annually. This report summarized the company's energy resource activities and presented an operations review as well as consolidated financial statements and common share information. This included the utility's assets, liabilities, revenues, expenses and cash flows. Revenue and expenditure statements were summarized by source. refs., tabs., figs

  7. HDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation

    Science.gov (United States)

    Zhang, Meng; Charles, River; Tong, Huimin; Zhang, Lei; Patel, Mili; Wang, Francis; Rames, Matthew J.; Ren, Amy; Rye, Kerry-Anne; Qiu, Xiayang; Johns, Douglas G.; Charles, M. Arthur; Ren, Gang

    2015-03-01

    Cholesteryl ester transfer protein (CETP) mediates the transfer of cholesterol esters (CE) from atheroprotective high-density lipoproteins (HDL) to atherogenic low-density lipoproteins (LDL). CETP inhibition has been regarded as a promising strategy for increasing HDL levels and subsequently reducing the risk of cardiovascular diseases (CVD). Although the crystal structure of CETP is known, little is known regarding how CETP binds to HDL. Here, we investigated how various HDL-like particles interact with CETP by electron microscopy and molecular dynamics simulations. Results showed that CETP binds to HDL via hydrophobic interactions rather than protein-protein interactions. The HDL surface lipid curvature generates a hydrophobic environment, leading to CETP hydrophobic distal end interaction. This interaction is independent of other HDL components, such as apolipoproteins, cholesteryl esters and triglycerides. Thus, disrupting these hydrophobic interactions could be a new therapeutic strategy for attenuating the interaction of CETP with HDL.

  8. Serum- and HDL3-serum amyloid A and HDL3-LCAT activity are influenced by increased CVD-burden

    OpenAIRE

    McEneny, Jane; McKavanagh, Peter; York, Edmund; Nadeem, Nida; Harbinson, Mark; Stevenson, Michael; Ball, Peter; Lusk, Lisa; Trinick, Thomas; Young, Ian S; McKay, Gareth J; Donnelly, Patrick M.

    2016-01-01

    BACKGROUND: High density lipoproteins (HDL) protect against cardiovascular disease (CVD). However, increased serum amyloid-A (SAA) related inflammation may negate this property. This study investigated if SAA was related to CVD-burden.METHODS: Subjects referred to the rapid chest pain clinic (n = 240) had atherosclerotic burden assessed by cardiac computerised tomography angiography. Subjects were classified as: no-CVD (n = 106), non-obstructive-CVD, stenosis<50% (n = 58) or moderate/signi...

  9. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

    DEFF Research Database (Denmark)

    Christoffersen, Christina; Obinata, Hideru; Kumaraswamy, Sunil B;

    2011-01-01

    Protection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P), which maintains vascular integrity. We show that HDL-associated S1P is bound specifically to both human and murine apolipoprotein M (apoM). Thus, isolated human ApoM(+) HDL contained S1P, whereas ApoM(-) HDL did...

  10. HDL function and subclinical atherosclerosis in juvenile idiopathic arthritis

    Science.gov (United States)

    Mani, Preethi; Uno, Kiyoko; Duong, MyNgan; Wolski, Kathy; Spalding, Steven; Husni, M. Elaine

    2016-01-01

    Background Increasing evidence suggests that inflammation adversely impacts the protective properties of high-density lipoproteins (HDL) and progression of atherosclerosis. The impact of early chronic inflammatory conditions on HDL function and vascular risk has not been well investigated. Methods We compared measures of HDL particle distribution and functionality, in addition to measures of carotid intima-medial thickness (cIMT) in patients with juvenile idiopathic arthritis (JIA) and age matched controls. Results JIA patients demonstrated lower levels of HDL cholesterol [47.0 (40.0, 56.0) vs. 56.0 (53.0, 61.0) mg/dL, P=0.04], total HDL [29.5 (27.9, 32.3) vs. 32.9 (31.6, 36.3) mg/dL, P=0.05] and large HDL [5.1 (3.7, 7.3) vs. 8.0 (6.7, 9.7) mg/dL, P=0.04] particles. In association JIA patients demonstrated greater cholesterol efflux mediated via ATP binding cassette A1 (ABCA1) [17.3% (12.8, 19.7) vs. 10.0% (5.8, 16.0), P=0.05] and less efflux mediated via ATP binding cassette G-1 (ABCG1) [3.2% (2.0, 3.9) vs. 4.8% (3.5, 5.8), P=0.01] and SR-B1 [6.9% (6.0, 8.4) vs. 9.1% (8.6, 10.2), P=0.002] compared with controls. Exposure of macrophages to serum from JIA patients resulted in a smaller increase in mRNA expression of ABCA1 (2.0±0.95 vs. 7.1±5.7 fold increase, P=0.01) and greater increases in expression of ABCG1 [1.4 (0.9, 1.5) vs. 0.8 (0.7, 1.1) fold increase, P=0.04] and SR-B1 (1.3±0.47 vs. 0.7±0.3 fold increase, P=0.001) compared with controls. Arylesterase (128.9±27.6 vs. 152.0±45.2 umoles/min/mL, P=0.04) activity and endothelial cell migration (491.2±68.9 vs. 634.2±227.4 cells/field, P=0.01) were less in JIA patients. No differences in cIMT were observed between JIA patients and controls. Conclusions The presence of JIA was associated with alterations in HDL particle distribution, cholesterol efflux and non-lipid transporting activities. The ultimate implication of these findings for cardiovascular risk requires further investigation. PMID:26885490

  11. Regional variations in HDL metabolism in human fat cells: effect of cell size

    International Nuclear Information System (INIS)

    Abdominal obesity is related to reduced plasma high-density lipoprotein (HDL) cholesterol, and both are associated with cardiovascular disease risk. The authors have observed that plasma membranes from abdominal subcutaneous adipocytes have a greater HDL binding capacity than omental fat cell plasma membranes. The present study examined whether these binding characteristics could be due to differences in fat cell size or cholesterol concentration between the two adipose depots. Abdominal subcutaneous and deep omental fat were obtained from massively obese patients at surgery. Subcutaneous abdominal fat cells were significantly larger and their cellular cholesterol content greater than omental adipocytes. The uptake of HDL by collagenase-isolated fat cells was studied by incubating the cells for 2 h at 370C with 10 μg/ml 125I-HDL2 or 125I-HDL3. In both depots, the cellular uptake of 125I-HDL2 and 125I-HDL3 was specifically inhibited by addition of 25-fold excess unlabeled HDL and a close correlation was observed between the cellular uptake of 125I-HDL2 and 125I-HDL3. In obese patients, the uptake of 125I-HDL was higher in subcutaneous cells than in omental cells. The cellular 125I-HDL uptake was significantly correlated with adipocyte size and fat cell cholesterol content but not with adipocyte cholesterol concentration. These results suggest that the higher HDL uptake observed in subcutaneous cells compared with omental cells in obesity is the result of differences in adipocyte size rather than differences in the cholesterol concentration (cholesterol-to-triglyceride ratio). The increased interaction of HDL with hypertrophied abdominal adipocytes may play an important role in determining the lipid composition of HDL in obesity

  12. Regional variations in HDL metabolism in human fat cells: effect of cell size

    Energy Technology Data Exchange (ETDEWEB)

    Despres, J.; Fong, B.S.; Julien, P.; Jimenez, J.; Angel, A.

    1987-05-01

    Abdominal obesity is related to reduced plasma high-density lipoprotein (HDL) cholesterol, and both are associated with cardiovascular disease risk. The authors have observed that plasma membranes from abdominal subcutaneous adipocytes have a greater HDL binding capacity than omental fat cell plasma membranes. The present study examined whether these binding characteristics could be due to differences in fat cell size or cholesterol concentration between the two adipose depots. Abdominal subcutaneous and deep omental fat were obtained from massively obese patients at surgery. Subcutaneous abdominal fat cells were significantly larger and their cellular cholesterol content greater than omental adipocytes. The uptake of HDL by collagenase-isolated fat cells was studied by incubating the cells for 2 h at 37/sup 0/C with 10 ..mu..g/ml /sup 125/I-HDL/sub 2/ or /sup 125/I-HDL/sub 3/. In both depots, the cellular uptake of /sup 125/I-HDL/sub 2/ and /sup 125/I-HDL/sub 3/ was specifically inhibited by addition of 25-fold excess unlabeled HDL and a close correlation was observed between the cellular uptake of /sup 125/I-HDL/sub 2/ and /sup 125/I-HDL/sub 3/. In obese patients, the uptake of /sup 125/I-HDL was higher in subcutaneous cells than in omental cells. The cellular /sup 125/I-HDL uptake was significantly correlated with adipocyte size and fat cell cholesterol content but not with adipocyte cholesterol concentration. These results suggest that the higher HDL uptake observed in subcutaneous cells compared with omental cells in obesity is the result of differences in adipocyte size rather than differences in the cholesterol concentration (cholesterol-to-triglyceride ratio). The increased interaction of HDL with hypertrophied abdominal adipocytes may play an important role in determining the lipid composition of HDL in obesity.

  13. Higher hdl levels are a preventive factor for metabolic syndrome in obese Turkish children.

    Science.gov (United States)

    Özer, Samet; Yılmaz, Resul; Özlem Kazanci, Nafia; Sönmezgöz, Ergün; Karaaslan, Erhan; Altuntaş, Buket; Emre Kuyucu, Yunus

    2014-10-03

    Objetivo: El síndrome metabólico infantil no ha sido definido aún con claridad. La obesidad infantil se está incrementando progresivamente al igual que la incidencia del síndrome metabólico infantil. Nuestro objetivo ha sido mostrar los componentes del síndrome metabólico y sus factores preventivos en los niños obesos. Metodología: Este estudio analizó de forma retrospectiva a 187 niños y adolescentes obesos de entre 5 y 18 años. Los datos demográficos, las medidas antropomórficas, los índices de masa corporal, los valores de presión sanguínea, los niveles de insulina, los resultados de test de tolerancia a la glucosa oral, el total de colesterol, las lipoproteínas de gran densidad y los niveles de triglicéridos fueron obtenidos de registros hospitalarios. Una masa corporal con un índice superior a 95 percentiles fue considerada como obesidad. La resistencia a la insulina se calculó de acuerdo con el test de tolerancia a la glucosa oral con 1,75 g/kg de glucosa y un máximo de 75 gramos de glucosa. Se calculó y comparó el índice de sensibilidad a la insulina y la evaluación del modelos homeostático- resistencia a la insulina (HOMA IR). El síndrome metabólico fue diagnosticado de acuerdo con los nuevos criterios de la OMS adaptados a los síndromes metabólicos infantiles. Resultados: Se observó una homeostasis de glucosa anormal en el 53% de los casos. La dislipidemia estaba presente en el 45,7% de los pacientes y la hipertensión en un 16,6%. El síndrome metabólico fue identificado en un 24,6% de los niños y adolescentes obesos. Altos valores de HOMA-IR y de glucosa, triglicéridos elevados y niveles bajos de HDL eran indicadores de síndrome metabólico. Conclusión: La obesidad y la resistencia a la insulina son factores significativos para el desarrollo del síndrome metabólico en niños y adolescentes. En niños obesos altos niveles de HDL son un factor preventivo del síndrome metabólico. Prevenir la obesidad y la

  14. Aprendizaje cooperativo con alumnos de altas capacidades

    OpenAIRE

    Herrera Lara, Inmaculada

    2016-01-01

    El presente Trabajo Fin de Grado tiene como finalidad conocer e investigar la intervención educativa que se lleva a cabo con los alumnos de altas capacidades a través del aprendizaje cooperativo. Estos alumnos necesitan de la ayuda y colaboración de los otros para lograr verdaderos procesos de aprendizaje. Sin la colaboración de docentes, padres y demás organismos del centro educativo no sería posible ofrecer una respuesta válida y eficaz a las necesidades que presenta este colectivo. Tal com...

  15. Low HDL cholesterol, aggression and altered central serotonergic activity.

    Science.gov (United States)

    Buydens-Branchey, L; Branchey, M; Hudson, J; Fergeson, P

    2000-03-01

    Many studies support a significant relation between low cholesterol levels and poor impulse, aggression and mood control. Evidence exists also for a causal link between low brain serotonin (5-HT) activity and these behaviors. Mechanisms linking cholesterol and hostile or self-destructive behavior are unknown, but it has been suggested that low cholesterol influences 5-HT function. This study was designed to explore the relationship between plasma cholesterol, measures of impulsivity and aggression, and indices of 5-HT function in personality disordered cocaine addicts. Thirty-eight hospitalized male patients (age 36.8+/-7.1) were assessed with the DSM-III-R, the Buss-Durkee Hostility Inventory (BDHI), the Barratt Impulsiveness Scale (BIS) and the Brown-Goodwin Assessment for Life History of Aggression. Fasting basal cholesterol (total, LDL and HDL) was determined 2 weeks after cocaine discontinuation. On the same day 5-HT function was assessed by neuroendocrine (cortisol and prolactin) and psychological (NIMH and 'high' self-rating scales) responses following meta-chlorophenylpiperazine (m-CPP) challenges. Reduced neuroendocrine responses, 'high' feelings and increased 'activation-euphoria' following m-CPP have been interpreted as indicating 5-HT alterations in a variety of psychiatric conditions. Significantly lower levels of HDL cholesterol were found in patients who had a history of aggression (P=0.005). Lower levels of HDL cholesterol were also found to be significantly associated with more intense 'high' and 'activation-euphoria' responses as well as with blunted cortisol responses to m-CPP (P=0.033, P=0.025 and P=0.018, respectively). This study gives further support to existing evidence indicating that in some individuals, the probability of exhibiting impulsive and violent behaviors may be increased when cholesterol is low. It also suggests that low cholesterol and alterations in 5-HT activity may be causally related.

  16. Bile acids reduce endocytosis of high-density lipoprotein (HDL in HepG2 cells.

    Directory of Open Access Journals (Sweden)

    Clemens Röhrl

    Full Text Available High-density lipoprotein (HDL transports lipids to hepatic cells and the majority of HDL-associated cholesterol is destined for biliary excretion. Cholesterol is excreted into the bile directly or after conversion to bile acids, which are also present in the plasma as they are effectively reabsorbed through the enterohepatic cycle. Here, we provide evidence that bile acids affect HDL endocytosis. Using fluorescent and radiolabeled HDL, we show that HDL endocytosis was reduced in the presence of high concentrations of taurocholate, a natural non-cell-permeable bile acid, in human hepatic HepG2 and HuH7 cells. In contrast, selective cholesteryl-ester (CE uptake was increased. Taurocholate exerted these effects extracellularly and independently of HDL modification, cell membrane perturbation or blocking of endocytic trafficking. Instead, this reduction of endocytosis and increase in selective uptake was dependent on SR-BI. In addition, cell-permeable bile acids reduced HDL endocytosis by farnesoid X receptor (FXR activation: chenodeoxycholate and the non-steroidal FXR agonist GW4064 reduced HDL endocytosis, whereas selective CE uptake was unaltered. Reduced HDL endocytosis by FXR activation was independent of SR-BI and was likely mediated by impaired expression of the scavenger receptor cluster of differentiation 36 (CD36. Taken together we have shown that bile acids reduce HDL endocytosis by transcriptional and non-transcriptional mechanisms. Further, we suggest that HDL endocytosis and selective lipid uptake are not necessarily tightly linked to each other.

  17. HDL-apoA-I exchange: rapid detection and association with atherosclerosis.

    Directory of Open Access Journals (Sweden)

    Mark S Borja

    Full Text Available High density lipoprotein (HDL cholesterol levels are associated with decreased risk of cardiovascular disease, but not all HDL are functionally equivalent. A primary determinant of HDL functional status is the conformational adaptability of its main protein component, apoA-I, an exchangeable apolipoprotein. Chemical modification of apoA-I, as may occur under conditions of inflammation or diabetes, can severely impair HDL function and is associated with the presence of cardiovascular disease. Chemical modification of apoA-I also impairs its ability to exchange on and off HDL, a critical process in reverse cholesterol transport. In this study, we developed a method using electron paramagnetic resonance spectroscopy (EPR to quantify HDL-apoA-I exchange. Using this approach, we measured the degree of HDL-apoA-I exchange for HDL isolated from rabbits fed a high fat, high cholesterol diet, as well as human subjects with acute coronary syndrome and metabolic syndrome. We observed that HDL-apoA-I exchange was markedly reduced when atherosclerosis was present, or when the subject carries at least one risk factor of cardiovascular disease. These results show that HDL-apoA-I exchange is a clinically relevant measure of HDL function pertinent to cardiovascular disease.

  18. HDL code analysis for ASICs in mobile systems

    OpenAIRE

    Wickberg, Fredrik

    2007-01-01

    The complex work of designing new ASICs today and the increasing costs of time to market (TTM) delays are putting high responsibility on the research and development teams to make fault free designs. The main purpose of implementing a static rule checking tool in the design flow today is to find errors and bugs in the hardware definition language (HDL) code as fast and soon as possible. The sooner you find a bug in the design, the shorter the turnaround time becomes, and thereby both time and...

  19. Serum TC/HDL-C,TG/HDL-C and LDL-C/HDL-C in predicting the risk of myocardial infarction in normolipidae-mic patients in South Asia:A case-control study

    Institute of Scientific and Technical Information of China (English)

    Arun Kumar; Ramiah Sivakanesan

    2008-01-01

    Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol (LDL-C)is the main therapeutic target in the pre-vention of CVD.Increased triglycerides (TG)and decreased high-density lipoprotein (LDL-C)are considered to be a major risk factor for the development of insulin resistant and metabolic syndrome.Although the TG/HDL-C ratio has been used in recent studies as a clinical indicator for insulin resistance,results were inconsis-tent.The TG/HDL-C ratio is also widely used to assess the lipid atherogenesis.How ever the utility of this rate for predicting coronary heart disease (CHD)risk is not clear.We encountered myocardial infarct patients with normal serum lipid concentration so this study was undertaken to evaluate the usefulness of these lipid ratios in predicting CHD risk in normolipidemic AMI patients and to compare the results with healthy subjects.The aim of the present study was to evaluate serum TC/HDL-C,TG/HDL-C and LDL-C/HDL-C in myocardial infarct subjects with normal lipid profile.To study this,lipid profile was determined in 165 normolipidemic acute myo-cardial infarction patients and 165 age/sex-matched controls.Total cholesterol,triglycerides,and HDL-cho-lesterol were analyzed enzymatically using kits obtained from Randox Laboratories Limited,Crumlin,UK. Plasma LDL-cholesterol was determined from the values of total cholesterol and HDL- cholesterol using the friedwalds formula.The values were expressed as means ± standard deviation (SD)and data from patients and controls was compared using students't'-test.The results and conclusion of the study were:Total cholester-ol,TC:HDL-C ratio,triglycerides,LDL-cholesterol,LDL:HDL-C ratio were higher in MI patients (p<0. 001).HDL-C concentration was significantly lower in MI patients than controls (p<0.001).Higher ratio of TC/HDL-C,TG/HDL-C and LDL-C/HDL-C was observed in AMI patients compared

  20. High efficiency motors; Motores de alta eficiencia

    Energy Technology Data Exchange (ETDEWEB)

    Uranga Favela, Ivan Jaime [Energia Controlada de Mexico, S. A. de C. V., Mexico, D. F. (Mexico)

    1992-12-31

    This paper is a technical-financial study of the high efficiency and super-premium motors. As it is widely known, more than 60% of the electrical energy generated in the country is used for the operation of motors, in industry as well as in commerce. Therefore the importance that the motors have in the efficient energy use. [Espanol] El presente trabajo es un estudio tecnico-financiero de los motores de alta eficiencia y los motores super premium. Como es ampliamente conocido, mas del 60% de la energia electrica generada en el pais, es utilizada para accionar motores, dentro de la industria y el comercio. De alli la importancia que los motores tienen en el uso eficiente de la energia.

  1. The improvement of large High-Density Lipoprotein (HDL) particle levels, and presumably HDL metabolism, depend on effects of low-carbohydrate diet and weight loss

    Science.gov (United States)

    Finelli, C.; Crispino, P.; Gioia, S.; La Sala, N.; D'amico, L.; La Grotta, M.; Miro, O.; Colarusso, D.

    2016-01-01

    Depressed levels of atheroprotective large HDL particles are common in obesity and cardiovascular disease (CVD). Increases in large HDL particles are favourably associated with reduced CVD event risk and coronary plaque burden. The objective of the study is to compare the effectiveness of low-carbohydrate diets and weight loss for increasing blood levels of large HDL particles at 1 year. This study was performed by screening for body mass index (BMI) and metabolic syndrome in 160 consecutive subjects referred to our out-patient Metabolic Unit in South Italy. We administered dietary advice to four small groups rather than individually. A single team comprised of a dietitian and physician administered diet-specific advice to each group. Large HDL particles at baseline and 1 year were measured using two-dimensional gel electrophoresis. Dietary intake was assessed via 3-day diet records. Although 1-year weight loss did not differ between diet groups (mean 4.4 %), increases in large HDL particles paralleled the degree of carbohydrate restriction across the four diets (p<0.001 for trend). Regression analysis indicated that magnitude of carbohydrate restriction (percentage of calories as carbohydrate at 1 year) and weight loss were each independent predictors of 1-year increases in large HDL concentration. Changes in HDL cholesterol concentration were modestly correlated with changes in large HDL particle concentration (r=0.47, p=.001). In conclusion, reduction of excess dietary carbohydrate and body weight improved large HDL levels. Comparison trials with cardiovascular outcomes are needed to more fully evaluate these findings. PMID:27103896

  2. Effect of HDL and apoAI on PGE2 Production by Monocyte-Derived Macrophages

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Summary: Effect of antiatherogenic high density lipoprotein (HDL) and apolipoprotein AI(apoAI) on production of prostaglandin E2(PGE2) by human monocyte-derived macrophages wasinvestigated. Macrophages were loaded with acetylated low density lipoprotein followed by incuba-tion with HDL3 or apoAI. PGE2 produced and secreted in culture supernatant was quantified by en-zyme immunoassay. HDL3 induced production of PGE2 by macrophages in a time-dependent man-ner. 24 h after incubation, PGE2 production by HDL3-treated macrophages increased 3. 7-fold ofthat by control cells. ApoAI also induced PGE2 secretion to 2. 1-fold, which was significantly lessthan HDL3. The data indicate that both HDL3 and lipid-free apoAI enhance PGE2 synthesis and se-cretion by human macrophages and this may further contribute to the protection from atheroscle-rosis.

  3. Transporte de juvenis de curimbatá Prochilodus lineatus em diferentes densidades =Transportation of curimbata Prochilodus lineatus juveniles in different densities

    Directory of Open Access Journals (Sweden)

    André Fernando Nascimento Gonçalves

    2010-04-01

    Full Text Available Neste estudo foi avaliado o efeito do transporte de curimbatá Prochilodus lineatus, em três densidades (100, 150 e 250 g L-1, sobre a sobrevivência e variáveis metabólicas, iônicas e hematológicas (série vermelha. Juvenis de curimbatá foram transportados em sacos plásticos durante 6h e amostrados antes da embalagem, imediatamente após a chegada, 24 e 96h após o transporte. Os peixes transportados na densidade mais alta apresentaram maior mortalidade durante o período de recuperação. As variáveis físico-químicas da água: condutividade e amônia total apresentaram maiores valores quanto maior a densidade (p This study evaluated the effects of curimbata Prochilodus lineatus transportation in three densities (100, 150 and 250 g L-1 on survival, metabolic, ionic and hematological (red series variables. Curimbata juveniles were transported in plastic bag during six hours, and sampled before packing, immediately after the arrival, 24 and 96 hours after transportation. During recovery, higher mortality was seen in fish transported in the highest density. Water variables, such as conductivity and total ammonia, presented increased values as density increased (p < 0.05, whereas the opposite occurred with dissolved oxygen. Glucose level observed in the arrival was high, significantly reducing after 96 hours. Among ionic variables, chloride decreased in higher fish densities and according to sampling times. Red series hematological variables, such as hematocrit, red blood cell and hemoglobin, increased in arrival, but diminished 96 hours after transportation. There were no significant differences in the interaction between density and time of sampling for mentioned variables. 250 g L-1 density induced the highest mortality rate and the worst variables values measured. 96 hours of recovery after the stressing event was enough to return to initial values for hematological variables, but was not sufficient to return to initial values for

  4. Automatic Circuit Extractor for HDL Description Using Program Slicing

    Institute of Scientific and Technical Information of China (English)

    Tun Li; Yang Guo; Si-Kun Li

    2004-01-01

    Design extraction and reduction have been extensively used in modern VLSI design process. The extracted and reduced design can be efficiently processed by various applications, such as formal verification,simulation, automatic test pattern generation (ATPG), etc. This paper presents a new circuit extraction method using program slicing technique, and develops an elegant theoretical basis based on program slicing for circuit extraction from Verilog description. The technique can obtain a chaining slice for given signals of interest. Compared with related researches, the main advantages of the method include that it is fine grain; it has no hardware description language (HDL) coding style limitation; it is precise and is capable of dealing with various Verilog constructions. The technique has been integrated with a commercial simulation environment and incorporated into a design process. The results of practical designs show the significant benefits of the approach.

  5. ApoA-I mutations, L202P and K131del, in HDL from heterozygotes with low HDL-C

    OpenAIRE

    Ljunggren, Stefan; Levels, Johannes H. M.; Turkina, Maria V.; Sundberg, Sofie; Bochem, Andrea E.; Hovingh, Kees; Holleboom, Adriaan G; Lindahl, Mats; Kuivenhoven, Jan Albert; Karlsson, Helen

    2014-01-01

    PURPOSE: Mutations in apolipoprotein A-I (apoA-I) may affect plasma high-density lipoprotein (HDL) cholesterol levels and the risk for cardiovascular disease but little is known about the presence and effects of circulating apoA-I variants. This study investigates whether the apoA-I mutations, apoA-I(L202P) and apoA-I(K131del) , are present on plasma HDL particles derived from heterozygote carriers and whether this is associated to changes in HDL protein composition. EXPERIMENTAL DESIGN: Plas...

  6. A paradoxical severe decrease in serum HDL-cholesterol after treatment with a fibrate

    OpenAIRE

    Crook, M; Lynas, J; Wray, R

    2000-01-01

    There have been a handful of reports in the literature of a paradoxical decrease in serum high density lipoprotein (HDL)-cholesterol in patients on fibrate drugs. The reason for this decline in cardioprotective HDL-cholesterol is not known and may have potential deleterious effects on the patient. This report describes a decrease in serum HDL-cholesterol in a patient on both simvastatin and bezafibrate. This patient also developed abnormal renal function, probably interstitial nephritis. In a...

  7. Predictors of impaired HDL function in HIV-1 infected compared to uninfected individuals

    OpenAIRE

    Kelesidis, Theodoros

    2016-01-01

    Objective: HDL function rather than absolute level may be a more accurate indicator for cardiovascular disease (CVD) but it is unclear what drives HDL dysfunction in HIV-1 infection. The objective of this study is to identify factors that may contribute to HDL dysfunction in chronic HIV-1 infection. Design: Retrospective study of HIV-1 infected males with low overall CVD risk and healthy males with no known CVD risk matched by race to the HIV-1 infected participants. Methods: We related para...

  8. Evaporation of carbon using electrons of a high density plasma; Evaporacion de carbono usando los electrones de un plasma de alta densidad

    Energy Technology Data Exchange (ETDEWEB)

    Muhl, S.; Camps, E.; Escobar A, L.; Garcia E, J.L.; Olea, O. [Instituto de Investigaciones en Materiales, UNAM, C.P. 04510 Mexico D.F. (Mexico)

    2000-07-01

    The high density plasmas are used frequently in the preparation of thin films or surface modification, for example to nitridation. In these processes, are used mainly the ions and the neutrals which compose the plasma. However, the electrons present in the plasma are not used, except in the case of chemical reactions induced by collisions, although the electron bombardment usually get hot the work piece. Through the adequate polarization of a conductor material, it is possible to extract electrons from a high density plasma at low pressure, that could be gotten the evaporation of this material. As result of the interaction between the plasma and the electron flux with the vapor produced, this last will be ionized. In this work, it is reported the use of this novelty arrangement to prepare carbon thin films using a high density argon plasma and a high purity graphite bar as material to evaporate. It has been used substrates outside plasma and immersed in the plasma. Also it has been reported the plasma characteristics (temperature and electron density, energy and ions flux), parameters of the deposit process (deposit rate and ion/neutral rate) as well as the properties of the films obtained (IR absorption spectra and UV/Vis, elemental analysis, hardness and refractive index). (Author)

  9. EFEITO DAS ALTAS DENSIDADES DE ESTOCAGEM NO CRESCIMENTO E SOBREVIVÊNCIA DE Litopenaeus vannamei NA FASE FINAL DE ENGORDA, CULTIVADOS EM SISTEMAS DE BIOFLOCOS (BFT

    Directory of Open Access Journals (Sweden)

    Adriana Ferreira Silva

    2013-09-01

    Full Text Available The aim of this study was to evaluate the effect of high stocking densities on survival, growth and feed conversion rates of Litopenaeus vannamei shrimp, in final growout phase, in a Biofloc Technology (BFT culture system, keeping the same water parameters for all treatments. Shrimps (11.96 ± 1.14 g were stocked in microcosms (0.50/m2 tanks, connected to a BFT system raceway. The study was carried out for 45 days. The shrimp were stocked at densities of 150, 300, 450 and 600 shrimp/m2. Bioflocs were collected for analysis of proximate composition. The results were submitted to one-way ANOVA, and differences were compared by Tukey test (α = 0.05. In T300 and T450, growth and survival were not affected by high stocking densities. The highest biomass reached (T450 was 5.1kg/m² and the best feed conversion rate was 1.54 in T150. The results of this study indicate that stocking densities in the proposed system can be high, but not exceeding 450 shrimp/m². Furthermore, even maintaining the same water parameters for all treatments, there was a negative effect between density and shrimp growth, confirming that this effect is behavioral.

  10. Characterization of composite high density polyethylene and layered zirconium phosphate; Caracterizacao de composito de polietileno de alta densidade (HDPE) e fosfato de zirconio lamelar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    Zirconium phosphate (ZrP) (2 w%), synthesized by direct precipitation method, was used in the preparation of composite with high density polyethylene (HDPE), through extrusion processing in the molten state. Wide angle x-ray diffraction (WAXD), stress-strain mechanical analysis and scanning electron microscopy (SEM) techniques were used for ZrP, neat polymer and composite mechanical and morphologic characterization. Although there was a slight increase in the Young modulus, WAXD and SEM analysis showed that the intercalation of the HDPE matrix in the filler galleries did not occur, probably due to the insufficient lamellae spacing to intercalate the polymer chains. Then, a microcomposite was achieved. (author)

  11. World Wide Web Search Engines: AltaVista and Yahoo.

    Science.gov (United States)

    Machovec, George S., Ed.

    1996-01-01

    Examines the history, structure, and search capabilities of Internet search tools AltaVista and Yahoo. AltaVista provides relevance-ranked feedback on full-text searches. Yahoo indexes Web "citations" only but does organize information hierarchically into predefined categories. Yahoo has recently become a publicly held company and currently…

  12. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

    DEFF Research Database (Denmark)

    Elsøe, Sara; Ahnström, Josefin; Christoffersen, Christina;

    2012-01-01

    Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lip...... a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL....

  13. Advances in the Study of the Antiatherogenic Function and Novel Therapies for HDL

    Directory of Open Access Journals (Sweden)

    Peiqiu Cao

    2015-07-01

    Full Text Available The hypothesis that raising high-density lipoprotein cholesterol (HDL-C levels could improve the risk for cardiovascular disease (CVD is facing challenges. There is multitudinous clear clinical evidence that the latest failures of HDL-C-raising drugs show no clear association with risks for CVD. At the genetic level, recent research indicates that steady-state HDL-C concentrations may provide limited information regarding the potential antiatherogenic functions of HDL. It is evident that the newer strategies may replace therapeutic approaches to simply raise plasma HDL-C levels. There is an urgent need to identify an efficient biomarker that accurately predicts the increased risk of atherosclerosis (AS in patients and that may be used for exploring newer therapeutic targets. Studies from recent decades show that the composition, structure and function of circulating HDL are closely associated with high cardiovascular risk. A vast amount of data demonstrates that the most important mechanism through which HDL antagonizes AS involves the reverse cholesterol transport (RCT process. Clinical trials of drugs that specifically target HDL have so far proven disappointing, so it is necessary to carry out review on the HDL therapeutics.

  14. Turismo em territórios de grande densidade religiosa

    Directory of Open Access Journals (Sweden)

    Siegrid Guillaumon

    2012-12-01

    Full Text Available Resumo ----- O turismo tem sido entendido por organismos internacionais como atividade com grande potencial para promover o desenvolvimento econômico e, ao mesmo tempo, que valoriza a cultura e promove a preservação das paisagens naturais. Seguindo as diretrizes internacionais, no Brasil, o turismo passou a ser entendido como uma indústria com grande potencial para gerar empregos e divisas, e se fortalece por meio da promoção da diversidade cultural, que pode estar associada às diversas culturas materiais e religiosas. Para compreender a gestão do turismo em contextos que articulam cultura, religião e desenvolvimento territorial, este ensaio teórico aponta limitações nos dois conceitos disponíveis na literatura, quais sejam, o conceito de turismo cultural e o conceito de turismo religioso, ao mesmo tempo que propõe o conceito de ‘turismo em territórios de grande densidade religiosa’, o qual incorpora o reconhecimento das dinâmicas de poder presentes nos territórios como elementos que interferem na forma como se planeja o turismo. Mobilizam-se entendimentos do campo da antropologia e da geografi a para a gestão a fim de sustentar que a discussão teórica conduzida tem um potencial explicativo para o turismo em diversas escalas territoriais, e, também, em contextos nos quais existe o diálogo entre turismo e religião. ----- Tourism in Territories of High Religious Density ----- Abstract ----- Tourism has been understood by international organizations as an activity with great potential to promote economic development, while valuing cultures and promoting the protection of natural landscapes. Following international guidelines, tourism in Brazil has begun to be understood as an industry with great potential to generate jobs and income and is strengthened through the promotion of cultural diversity which may be associated with material and religious cultures. To understand the management of tourism in contexts that

  15. Fitomassa de adubos verdes e controle de plantas daninhas em diferentes densidades populacionias de leguminosas.

    OpenAIRE

    Fernandes, Marcelo Ferreira; Barreto, Antônio Carlos; Emídio Filho, João

    1999-01-01

    O objetivo deste trabalho foi avaliar a fitomassa de calopogônio, mucuna-preta, mucunarajada,feijão-de-porco, guandu de porte alto, Crotalaria spectabilis e C. breviflora sob diferentes densidades de semeadura (10, 20, 40, 80 e 160 sementes viáveis m-2), e o crescimento de plantas daninhas nessas densidades, em área de tabuleiros costeiros. O experimento foi desenvolvido de maio a agosto de 1996, no Campo Experimental “Antônio Martins”(EMDAGRO/Embrapa-CPATC), em Lagarto, SE. O número de plant...

  16. Estudio de la densidad mamográfica como modificador de riesgo de cáncer de mama en mujeres con mutación BRCA1/2

    OpenAIRE

    Tamayo Orjuela, Luisa Fernanda

    2015-01-01

    El cáncer de mama es el tumor más frecuente en la mujer y uno de los problemas de salud más importante por los índices de mortalidad y morbilidad asociados. Los factores de riesgo más frecuentes para desarrollar esta enfermedad son la historia familiar y la edad de la mujer. En un 5-10% de la población con cáncer de mama se detecta un tumor hereditario debido a una mutación heredada de los padres. Actualmente, la alta densidad mamográfica medida en las mamografías, se considera un factor ...

  17. Densidades de carga utilizadas para el transporte de bovinos destinados a matadero en Chile Stocking densities used to transport cattle to slaughter in Chile

    Directory of Open Access Journals (Sweden)

    C Gallo

    2005-01-01

    Full Text Available Se determinaron las densidades de carga empleadas en el transporte de 413 cargas (camionadas de bovinos, que comprendieron un total de 12.931 animales, recibidos en dos plantas faenadoras en Chile durante el año 2002, una en la X Región y la otra en la Región Metropolitana. Para las cargas recibidas en la planta de la X Región, las densidades de carga registradas fluctuaron entre 106 y 693 kg/m² (promedio 457 ± 6,6 kg/m² y en la Región Metropolitana fluctuaron entre 268 y 632 kg/m² (promedio 453 ± 9,7 kg/m². En ambas regiones se observó una tendencia a que las densidades de carga usadas en los vehículos de mayor tamaño (camiones simples y con carro fueran mayores; la mayoría de las cargas animales eran transportadas en este tipo de vehículo. Las densidades de carga encontradas para los viajes más largos no difirieron de aquellas usadas para los viajes cortos en el caso de la Región Metropolitana; sin embargo, en el caso de las cargas recibidas en la X Región se observó que en general los animales transportados por distancias más largas viajaron a densidades de carga mayores. En general, 32,4% de las 413 cargas revisadas, que correspondieron a 35,6% de todos los bovinos, sobrepasaron el límite de densidad de carga permitido por la legislación vigente (500 kg/m². Considerando que la literatura indica que el ganado bovino transportado a muy altas densidades, particularmente sobre 500 kg/m², sufre mayor estrés y produce inferior calidad de carne, especialmente en términos de mayor incidencia de contusiones, y que, además, en Chile las canales con contusiones que afectan el tejido muscular sufren una degradación en cuanto a la categoría de tipificación, reduciendo su valor económico, se recomienda, tanto desde el punto de vista de bienestar animal como de calidad de carne, al menos respetar el límite máximo de densidad de carga establecido para el transporte de ganado bovino en ChileThe stocking densities employed in

  18. HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes

    NARCIS (Netherlands)

    Meurs, I.; Hoekstra, M; van Wanrooij, EJA; Hildebrand, RB; Kuiper, J; Kuipers, F; Hardeman, MR; Van Berkel, TJC; Van Eck, M

    2005-01-01

    Objective. Scavenger receptor class B, type I (SR-BI) is a multifunctional receptor that promotes the selective uptake of cholesteryl esters from high-density lipoprotein (HDL). Disruption of SR-BI in mice results in a dramatic increase in HDL cholesterol. Interestingly, mice lacking SR-BI also deve

  19. Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL

    NARCIS (Netherlands)

    Van Eck, Miranda; Hoekstra, Menno; Hildebrand, Reeni B.; Yaong, Yuemang; Stengel, Dominique; Kruijt, J. Kar; Sattler, Wolfgang; Tietge, Uwe J. F.; Ninio, Ewa; Van Berkel, Theo J. C.; Pratico, Domenico

    2007-01-01

    Objective-In the current study the effect of disruption of SR-BI, a prominent regulator of HDL metabolism, on the activity of the HDL-associated antioxidant enzymes PON1 and PAF-AH as well as in vivo oxidative stress were investigated. Methods and Results-SR-BI deficiency resulted in 1.4-fold (P Con

  20. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

    DEFF Research Database (Denmark)

    Postmus, Iris; Warren, Helen R; Trompet, Stella;

    2016-01-01

    BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation. METHODS AND RESULTS: We perform...

  1. The HDL hypothesis : does high-density lipoprotein protect from atherosclerosis?

    NARCIS (Netherlands)

    Vergeer, Menno; Holleboom, Adriaan G; Kastelein, John J P; Kuivenhoven, Jan Albert

    2010-01-01

    There is unequivocal evidence of an inverse association between plasma high-density lipoprotein (HDL) cholesterol concentrations and the risk of cardiovascular disease, a finding that has led to the hypothesis that HDL protects from atherosclerosis. This review details the experimental evidence for

  2. A disposable electrochemical sensor based on protein G for High-Density Lipoprotein (HDL) detection.

    Science.gov (United States)

    Chammem, H; Hafaid, I; Bohli, N; Garcia, A; Meilhac, O; Abdelghani, A; Mora, L

    2015-11-01

    In this work, two biosensors were developed for the detection of High-Density Lipoproteins (HDL) particles, which are biomarkers inversely correlated with cardiovascular risk and which represent therapeutic targets for atherosclerosis. The electrochemical properties of the grafted antibody on interdigitated gold electrode were achieved by Impedance Spectroscopy (IS). The used deposition method was based on oriented antibody Anti-ApoA1 with an intermediate thin layer of protein G. The developed biosensor was able to detect both native plasma HDL and reconstituted HDL (rHDL) particles respectively with the detection limit of 50n g/mL and 1 ng/mL, respectively. Dynamic contact angle and atomic force microscopy were used. The developed biosensors are able to differentiate the HDL particles according to their differences in size and interactions with the immobilized antibody. PMID:26452849

  3. Efeito da densidade de estocagem no desenvolvimento inicial do acará-bandeira (Pterophyllum scalare

    Directory of Open Access Journals (Sweden)

    L.P. Gonçalves Júnior

    2013-08-01

    Full Text Available Avaliou-se a influência da densidade de estocagem no desenvolvimento inicial do acará-bandeira (Pterophyllum scalare. O desempenho produtivo foi avaliado pelo ganho de peso (GP, ganho de comprimento total (GCT, ganho de comprimento padrão (GCP, ganho de altura (GA, taxa de crescimento específico (TCE, taxa de desenvolvimento específico (TDE e sobrevivência (S. Para realização do experimento, foram utilizadas 300 pós-larvas de peso médio inicial de 0,0012g, comprimento total médio de 4,11±0,93mm, altura média inicial de 4,84±0,87mm e comprimento padrão médio de 1,54±0,25mm. Essas foram distribuídas em delineamento inteiramente ao acaso, em cinco tratamentos com quatro repetições. Os tratamentos (T foram constituídos por cinco diferentes densidades de estocagem, em que T1: 5 pós-larvas L-1; T2: 10 pós-larvas L-1; T3: 15 pós-larvas L-1; T4: 20 pós-larvas L-1; T5: 25 pós-larvas L-1. A densidade de 5 pós-larvas L-1 foi a que proporcionou o maior valor para crescimento. Contudo, essa densidade subestimou a utilização do espaço se comparada com a produtividade final da densidade de 15 pós-larvas L-1.

  4. Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins.

    Science.gov (United States)

    Brandenburg, Klaus; Jürgens, Gudrun; Andrä, Jörg; Lindner, Buko; Koch, Michel H J; Blume, Alfred; Garidel, Patrick

    2002-12-01

    The interaction of bacterial endotoxins [lipopolysaccharide (LPS) and the 'endotoxic principle' lipid A], with high-density lipoprotein (HDL) from serum was investigated with a variety of physical techniques and biological assays. HDL exhibited an increase in the gel to liquid crystalline phase transition temperature Tc and a rigidification of the acyl chains of the endotoxins as measured by Fourier-transform infrared spectroscopy and differential scanning calorimetry. The functional groups of the endotoxins interacting with HDL are the phosphates and the diglucosamine backbone. The finding of phosphates as target groups is in accordance to measurements of the electrophoretic mobility showing that the zeta potential decreases from -50 to -60 mV to -20 mV at binding saturation. The importance of the sugar backbone as further target structure is in accordance with the remaining negative potential and competition experiments with polymyxin B (PMB) and phase transition data of the system PMB/dephosphorylated LPS. Furthermore, endotoxin binding to HDL influences the secondary structure of the latter manifesting in a change from a mixed alpha-helical/beta-sheet structure to a predominantly alpha-helical structure. The aggregate structure of the lipid A moiety of the endotoxins as determined by small-angle X-ray scattering shows a change of a unilamellar/inverted cubic into a multilamellar structure in the presence of HDL. Fluorescence resonance energy transfer data indicate an intercalation of pure HDL, and of [LPS]-[HDL] complexes into phospholipid liposomes. Furthermore, HDL may enhance the lipopolysaccharide-binding protein-induced intercalation of LPS into phospholipid liposomes. Parallel to these observations, the LPS-induced cytokine production of human mononuclear cells and the reactivity in the Limulus test are strongly reduced by the addition of HDL. These data allow to develop a model of the [endotoxin]/[HDL] interaction. PMID:12444987

  5. Efecto de diámetro de esfera y densidad celular en la producción de etanol con levadura inmovilizada en alginato

    Directory of Open Access Journals (Sweden)

    Martha V. Jiménez

    2011-07-01

    Full Text Available Effect of pellet diameter and cell density on ethanol production with alginate immobilized yeast Título corto: Producción de etanol con levadura inmovilizada ResumenLas células inmovilizadas tienen aplicación potencial en la producción de biocombustibles posibilitando la reutilización de biomasa, el empleo de diversas configuraciones de reactores y sistemas de cultivo, el manejo de altas densidades celulares alcanzando altas productividades volumétricas, y la simplificación de operaciones de procesamiento de salida. El objetivo del presente estudio fue evaluar la influencia del diámetro de las perlas y la densidad celular en la producción de etanol con Saccharomyces uvarum inmovilizada en alginato al 2% (p/v. Para ello se evaluaron tres diámetros de perlas de 2, 2,5 y 3 mm. Las células inmovilizadas fueron cultivadas en medio con 12% (p/v de glucosa en biorreactores de columna sin agitación a 28 ºC, y se operaron cuatro lotes consecutivos de 48 horas cada uno. En cada lote se cuantificó el consumo de glucosa y se determinó la cantidad de etanol producido. Los rendimientos máximos de etanol para las esferas de 2, 2,5 y 3 mm de diámetro fueron 81, 83 y 97% del rendimiento teórico. La máxima productividad volumétrica de etanol fue 1,2 g/L-1/h-1 con un consumo de glucosa de 99,8% al término del lote, correspondiente a las columnas con perlas de 3 mm y con una producción de 0,017 g de etanol por esfera. La producción de etanol acumulada en cada sistema fue 178, 189 y 200 g/L-1 para 2, 2,5 y 3 mm respectivamente, encontrándose una relación directa con el diámetro de perla e inversa respecto a la densidad celular. Los rendimientos de etanol obtenidos son superiores a los reportados para la misma especie. Palabras clave: inmovilización, alginato, Saccharomyces uvarum, etanol, lote repetido.AbstractImmobilized cells have a potential use in biofuel production. They also allow re-using biomass, using diverse reactor

  6. Alta Capital venitab Kruudale tasumisega / Sten-Aleks Pihlak

    Index Scriptorium Estoniae

    Pihlak, Sten-Aleks

    2008-01-01

    Alta Capital Partnersid pole veel maksnud Oliver Kruudale 2007. aasta septembris müüdud Tere ja Kalevi eest. Vt. samas: Rahasaamise venimine on lükanud Kalevi viimastel kuudel laenurallile. Kommenteerib Aivar Häelm

  7. COMPARISION OF BODY MASS INDEX (BMI WITH HIGH DENSITY LIPOPROTEIN (HDL LEVELS IN OBESE PEOPLE

    Directory of Open Access Journals (Sweden)

    Anitha

    2015-11-01

    Full Text Available NTRODUCTION: Cardiovascular disease is a major cause of morbidity and mortality in industrialized nations. Serum lipid concentrations are related to cardiovascular disease risk and one notable association is a statistically significant inverse correlation between HDL-cholesterol concentrations and the probability of developing coronary artery disease. A major related cardiovascular disease risk factor is obesity. Excess body weight is closely linked to low serum HDL-cholesterol concentrations. The general assumption now is that excessive body weight is associated with enlarged adipose tissue deposits, visceral adipose tissue in particular, which in turn are accompanied by elevated serum triacylglycerol concentrations. A well-studied inverse association exists between serum triacylglycerol and HDL-cholesterol concentrations and this may explain the observed low serum HDL-cholesterol concentrations in obesity. This study is done to confirm the above fact. MATERIALS AND METHODS: The subjects for the study were 100 males in the age group of 21 to 40 years. The subjects taken as obese were 50 and those taken as controls were 50. Obesity was taken into account according to the Body Mass Index. RESULTS: Paired T test is done. Results show that 34/50 subjects with BMI 40mg/dl. 40/50 obese patients with BMI >25kg/m2 show HDL levels of <40mg/dl. Significant P value is seen. The study shows that BMI is inversely related to HDL cholesterol levels. DISCUSSION: High HDL cholesterol, above 60 mg/dl is associated with low risk of coronary heart disease. HDL cholesterol below 40 mg/dL is considered too low and appears to be an independent risk factor for coronary artery disease. Low HDL cholesterol is one of the most common phenotypes seen in persons with premature heart disease. Obesity is associated with low HDL cholesterol levels and high triglyceride levels. A negative correlation exists between HDL cholesterol and body-mass index (BMI, meaning that HDL

  8. Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment.

    Science.gov (United States)

    Gagnon, France; Jarvik, Gail P; Motulsky, Arno G; Deeb, Samir S; Brunzell, John D; Wijsman, Ellen M

    2003-11-01

    The APOA1-C3-A4-A5 gene complex encodes genes whose products are implicated in the metabolism of HDL and/or triglycerides. Although the relationship between polymorphisms in this gene cluster and dyslipidemias was first reported more than 15 years ago, association and linkage results have remained inconclusive. This is due, in part, to the oligogenic and multivariate nature of dyslipidemic phenotypes. Therefore, we investigate evidence of linkage of APOC3 and HDL using two samples of dyslipidemic pedigrees: familial combined hyperlipidemia (FCHL) and isolated low-HDL (ILHDL). We used a strategy that deals with several difficulties inherent in the study of complex traits: by using a Bayesian Markov Chain Monte Carlo (MCMC) approach we allow for oligogenic trait models, as well as simultaneous incorporation of covariates, in the context of multipoint analysis. By using this approach on extended pedigrees we provide evidence of linkage of APOC3 and HDL level variation in two samples with different ascertainment. In addition to APOC3, we estimate that two to three genes, each with a substantial effect on total variance, are responsible for HDL variation in both data sets. We also provide evidence, using the FCHL data set, for a pleiotropic effect between HDL, HDL3 and triglycerides at the APOC3 locus.

  9. Coenzyme O*U1*UO, Alpha-Tocopherol and Free Cholesterol in HDL and LDL Fractions

    DEFF Research Database (Denmark)

    Johansen, Kurt; Theorell, Henning; Karlsson, Jan;

    1991-01-01

    Farmakologi, Alpha-tocopherol, Coenzyme Q*U1*U0, free cholesterol, LDL, Antioxidants, Lipoproteins, HDL......Farmakologi, Alpha-tocopherol, Coenzyme Q*U1*U0, free cholesterol, LDL, Antioxidants, Lipoproteins, HDL...

  10. Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raisingA systematic review and meta-analysis of relevant preclinical studies and clinical trials

    NARCIS (Netherlands)

    Kühnast, S.; Fiocco, M.; Hoorn, J.W.A. van der; Princen, H.M.G.; Jukema, J.W.

    2015-01-01

    Non-HDL-cholesterol is well recognised as a primary causal risk factor in cardiovascular disease. However, despite consistent epidemiological evidence for an inverse association between HDL-C and coronary heart disease, clinical trials aimed at raising HDL-C (AIM-HIGH, HPS2-THRIVE, dal-OUTCOMES) fai

  11. Pro-oxidant HDL predicts poor outcome in patients with ST-elevation acute coronary syndrome.

    Science.gov (United States)

    Distelmaier, Klaus; Schrutka, Lore; Seidl, Veronika; Winter, Max P; Wurm, Raphael; Mangold, Andreas; Perkmann, Thomas; Maurer, Gerald; Adlbrecht, Christopher; Lang, Irene M

    2015-07-01

    Oxidative stress affects clinical outcome in patients with ST-elevation acute coronary syndrome (STE-ACS). Although high-density lipoprotein (HDL) particles are generally considered protective, deleterious properties of HDL have been observed in patients with acute myocardial infarction. Here, we analysed the association between pro-oxidant HDL and all-cause mortality in STE-ACS patients. We determined the antioxidant function of HDL in 247 prospectively enrolled patients undergoing primary percutaneous coronary intervention for STE-ACS. Patients were stratified as by a pro-oxidant serum HDL oxidant index (HOI≥ 1) or with an antioxidant serum HOI (HOL< 1) capacity. Multivariate regression analysis was used to relate HOI to survival. The median follow-up time was 23 months (IQR 14.4-40.0 months). Pro-oxidant HDL was observed in 44.1 % of STE-ACS patients and was independently associated with all-cause mortality with a hazard ratio of 3.30(95 %CI 1.50-7.27, p = 0.003). Mortality rates were higher in patients with baseline pro-oxidant HDL compared to patients with preserved HDL function at 30 days (11.9 % vs 2.2 %, p=0.002), and at 4 years (22.9 % vs 8.7 %, p=0.002). Elevated neutrophil counts were a strong and independent predictor for pro-oxidant HDL with an odds ratio per standard deviation of 1.50 (95 %CI 1.11-2.03, p=0.008), as was history of prior acute myocardial infarction, elevated triglycerides levels and reduced glomerular filtration rate. In conclusion, pro-oxidant HDL represents a strong and independent predictor of long-term as well as short-term all-cause mortality in STE-ACS patients. Elevated neutrophil counts predicted the presence of serum pro-oxidant HDL. The maintenance of HDL functions might be a promising therapeutic target in STE-ACS patients.

  12. Role of HDL in cholesteryl ester metabolism of lipopolysaccharide-activated P388D1 macrophages[S

    OpenAIRE

    Uda, Sabrina; Spolitu, Stefano; Angius, Fabrizio; Collu, Maria; Accossu, Simonetta; Banni, Sebastiano; Murru, Elisabetta; Sanna, Francesca; Batetta, Barbara

    2013-01-01

    Infections share with atherosclerosis similar lipid alterations, with accumulation of cholesteryl esters (CEs) in activated macrophages and concomitant decrease of cholesterol-HDL (C-HDL). Yet the precise role of HDL during microbial infection has not been fully elucidated. Activation of P388D1 by lipopolysaccharide (LPS) triggered an increase of CEs and neutral lipid contents, along with a remarkable enhancement in 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate-HDL uptake...

  13. Where Are We With HDL Raising and Inhibition of Cholesteryl Ester Transfer for Heart Disease Risk Reduction?

    Science.gov (United States)

    Purpose: To review recent research in the area of high density lipoprotein (HDL) raising and coronary heart disease (CHD) risk reduction. Recent Findings: It is known that a decreased HDL cholesterol is an important CHD risk factor, and that raising HDL cholesterol has been associated with CHD risk...

  14. Intracellular cholesterol transport proteins enhance hydrolysis of HDL-CEs and facilitate elimination of cholesterol into bile.

    Science.gov (United States)

    Wang, Jing; Bie, Jinghua; Ghosh, Shobha

    2016-09-01

    While HDL-associated unesterified or free cholesterol (FC) is thought to be rapidly secreted into the bile, the fate of HDL-associated cholesteryl esters (HDL-CEs) that represent >80% of HDL-cholesterol, is only beginning to be understood. In the present study, we examined the hypothesis that intracellular cholesterol transport proteins [sterol carrier protein 2 (SCP2) and fatty acid binding protein-1 (FABP1)] not only facilitate CE hydrolase-mediated hydrolysis of HDL-CEs, but also enhance elimination of cholesterol into bile. Adenovirus-mediated overexpression of FABP1 or SCP2 in primary hepatocytes significantly increased hydrolysis of HDL-[(3)H]CE, reduced resecretion of HDL-CE-derived FC as nascent HDL, and increased its secretion as bile acids. Consistently, the flux of [(3)H]cholesterol from HDL-[(3)H]CE to biliary bile acids was increased by overexpression of SCP2 or FABP1 in vivo and reduced in SCP2(-/-) mice. Increased flux of HDL-[(3)H]CE to biliary FC was noted with FABP1 overexpression and in SCP2(-/-) mice that have increased FABP1 expression. Lack of a significant decrease in the flux of HDL-[(3)H]CE to biliary FC or bile acids in FABP1(-/-) mice indicates the likely compensation of its function by an as yet unidentified mechanism. Taken together, these studies demonstrate that FABP1 and SCP2 facilitate the preferential movement of HDL-CEs to bile for final elimination. PMID:27381048

  15. A densidade básica e característica anatômicas variam radialmente na madeira de Astronium graveolens Jacq. (Anacardiaceae. Basic density and anatomical features vary in the radial direction in the wood of Astronium graveolens Jacq. (Anacardiaceae.

    Directory of Open Access Journals (Sweden)

    Camila Moura SANTOS

    2011-12-01

    Full Text Available Estudos sobre variações nas dimensões celulares de espécies arbóreas de clima tropical são escassos. Sendo assim, o objetivo deste trabalho foi caracterizar a variação da densidade básica e da anatomia no sentido radial da madeira de Astronium graveolens Jacq. Coletaram-se cinco indivíduos da espécie, provenientes da Estação Experimental Luiz Antônio (SP. Os métodos empregados nas análises foram os usualmente utilizados em pesquisas de densidade e anatomia de madeira. De acordo com os resultados foram constatadas altas correlações entre densidade básica, comprimento de fibra, espessura da parede da fibra, diâmetro de vaso e frequência de vaso com a distância da medula. A densidade básica da madeira é altamente dependente do comprimento das fibras, espessura da parede das fibras e diâmetro dos vasos, ocorrendo aumento no sentido da medula para a casca.Studies on variations in cell sizes of tree species in tropical climate are scarce. Thus, the aim was characterize the radial variation of basic density and wood anatomy of Astronium graveolens Jacq. Five specimens were collected at the Luiz Antônio Experimental Station,(SP. Sstandard methods for studying the density and wood anatomy were employed. According to the results we observed high correlation among basic density,fiber length, fiber wall thickness, vessel diameter and vessel frequency with distance fromthe pith. The wood density is highly dependent on fiber length, fiber wall thicknessand vessel diameter, there was an increase towards the pith to bark.

  16. Carriles para alta velocidad. Comportamiento en fatiga

    Directory of Open Access Journals (Sweden)

    Duart, J. M.

    2005-02-01

    -aire inducido. Los ensayos de fatiga de los carriles soldados se llevan a cabo por flexión en cuatro puntos en concordancia con la norma europea. El método Locati, descrito en esta nota, está basado en la Ley de Miner de daño acumulado y en las curvas de Wohler del material ensayado. Permite calcular, con precisión suficiente, las tensiones límites de fatiga al 50%. Así, los valores obtenidos, en ensayos a dos millones de ciclos, para carriles sin soldar (Sf = 353 MPa, carriles soldados con precalentamiento de oxipropano (Sf = 225 MPa y carriles soldados con precalentamiento de propano-aire inducido (Sf = 210 MPa son muy similares y aceptables a los estipulados por los métodos de determinación del límite de fatiga según norma europea. Debido a la comodidad, rapidez y bajo coste del método Locati resulta, en nuestra opinión, muy adecuado para el control de calidad de los procesos de soldadura aluminotérmica en vigor, de carriles de alta resistencia.

  17. Anti-Brownian ELectrokinetic (ABEL) Trapping of Single High Density Lipoprotein (HDL) Particles

    Science.gov (United States)

    Bockenhauer, Samuel; Furstenberg, Alexandre; Wang, Quan; Devree, Brian; Jie Yao, Xiao; Bokoch, Michael; Kobilka, Brian; Sunahara, Roger; Moerner, W. E.

    2010-03-01

    The ABEL trap is a novel device for trapping single biomolecules in solution for extended observation. The trap estimates the position of a fluorescently-labeled object as small as ˜10 nm in solution and then applies a feedback electrokinetic drift every 20 us to trap the object by canceling its Brownian motion. We use the ABEL trap to study HDL particles at the single-copy level. HDL particles, essential in regulation of ``good'' cholesterol in humans, comprise a small (˜10 nm) lipid bilayer disc bounded by a belt of apolipoproteins. By engineering HDL particles with single fluorescent donor/acceptor probes and varying lipid compositions, we are working to study lipid diffusion on small length scales. We also use HDL particles as hosts for single transmembrane receptors, which should enable study of receptor conformational dynamics on long timescales.

  18. Comportamento de poedeiras criadas a diferentes densidades e tamanhos de grupo em ambiente enriquecido

    Directory of Open Access Journals (Sweden)

    Danilo Florentino Pereira

    2013-06-01

    Full Text Available O objetivo deste trabalho foi determinar diferenças comportamentais entre poedeiras criadas sob diferentes densidades e tamanhos de grupo, em condições de ambiente enriquecido. Foram utilizadas poedeiras Isa Brown com idade entre 30 e 32 semanas alojadas em galpões de escala reduzida e distorcida. As aves foram criadas durante 28 dias, em baias com cama de maravalha, poleiro e ninho. Foram avaliados dois tamanhos de grupos (6 e 12 aves e duas densidades de criação (774 e 1.440 cm² por ave, em arranjo fatorial com três repetições. Em amostras de vídeo de 15 min, foram registrados as frequências e os tempos de expressão dos comportamentos: arrumar penas, banho de areia, bater asas, beber água, bicar, coçar a cabeça, ciscar, comer, empoleirar, esticar perna, perseguir, sentar e visitar o ninho. Foram observados efeitos significativos dos tratamentos e da interação entre eles. O grupo de seis aves manifestou aumento da frequência de comportamentos que indicam maior frustração das aves, independentemente da densidade. O tamanho de grupo é o fator mais importante para o bem-estar das aves.

  19. How much does HDL cholesterol add to risk estimation? A report from the SCORE Investigators.

    LENUS (Irish Health Repository)

    Cooney, Marie Therese

    2009-06-01

    Systematic COronary Risk Evaluation (SCORE), the risk estimation system recommended by the European guidelines on cardiovascular disease prevention, estimates 10-year risk of cardiovascular disease mortality based on age, sex, country of origin, systolic blood pressure, smoking status and either total cholesterol (TC) or TC\\/high-density lipoprotein cholesterol (HDL-C) ratio. As, counterintuitively, these two systems perform very similarly, we have investigated whether incorporating HDL-C and TC as separate variables improves risk estimation.

  20. Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes

    OpenAIRE

    Storey, Stephen M.; McIntosh, Avery L.; Huang, Huan; Landrock, Kerstin K.; Martin, Gregory G.; Landrock, Danilo; Payne, H. Ross; Atshaves, Barbara P.; Kier, Ann B.; Schroeder, Friedhelm

    2012-01-01

    A major gap in our knowledge of rapid hepatic HDL cholesterol clearance is the role of key intracellular factors that influence this process. Although the reverse cholesterol transport pathway targets HDL to the liver for net elimination of free cholesterol from the body, molecular details governing cholesterol uptake into hepatocytes are not completely understood. Therefore, the effects of sterol carrier protein (SCP)-2 and liver fatty acid-binding protein (L-FABP), high-af...

  1. Cost Effectiveness of Treating Low HDL-Cholesterol in the Primary Prevention of Coronary Heart Disease

    OpenAIRE

    Joel W. Hay; Kimberly L. Sterling

    2005-01-01

    Background: A low serum level of high-density lipoprotein (HDL)-cholesterol is an independent risk factor for coronary heart disease (CHD). Fibrates, particularly gemfibrozil, have been shown to raise HDL-cholesterol levels and reduce the incidence of CHD. The literature on fibrate cost effectiveness is quite limited. Objective: The objective of this analysis is to determine the cost effectiveness of the fibrates gemfibrozil and fenofibrate in the primary prevention of CHD. The target populat...

  2. Molecular mechanisms responsible for the antiinflammatory and protective effect of HDL

    Directory of Open Access Journals (Sweden)

    Giuseppe D Norata

    2005-07-01

    Full Text Available Giuseppe D Norata1, Alberico L Catapano1,2 1Department of Pharmacological Sciences, University of Milan, Italy; 2Centro per lo Studio e la Prevenzione delle Vasculopatie Periferiche, Ospedale Bassini, Cinisello Balsamo, ItalyAbstract: In addition to their role in reverse cholesterol transport, high-density lipoproteins (HDL exert several beneficial effects, including the prevention and correction of endothelial dysfunction. HDL promote endothelium proliferation and diminish endothelial apoptosis; they play a key role in vasorelaxation by increasing the release of nitric oxide and prostacyclin through the induction of the expression and the activity of endothelial nitric oxide synthase and the coupling of cyclooxygenase 2 and prostacyclin synthase. In addition, HDL affect coagulation, fibrynolisis, platelet adhesion, adhesion molecules, and protease expression, and they exert antioxidant activity. These effects are achieved at the gene expression level and are dependent on the activation of several intracellular signaling pathways, including PI3K/Akt, ERK1/2, PKC, and p38MAPK. The complexity of the signaling pathways modulated by HDL reflects the different effects of the components of this class of lipoproteins such as apolipoproteins or lipids on endothelial cell gene expression and the subsequent modulation of endothelial function observed. The in vivo relevance of these findings to endothelial recovery during physiological or pathological conditions remains to be addressed; nevertheless, the results of clinical studies with synthetic HDL, ApoA-I mimetics, and drugs that are becoming available that selectively affect HDL plasma levels and biological functions support the importance of the correction of endothelial function by HDL.Keywords: HDL, endothelium, inflammation, molecular mechanisms, gene expression, intracellular kinases

  3. Effect of uremia on HDL composition, vascular inflammation, and atherosclerosis in wild-type mice

    DEFF Research Database (Denmark)

    Bang, Christian A; Bro, Susanne; Bartels, Emil D;

    2007-01-01

    Wild-type mice normally do not develop atherosclerosis, unless fed cholic acid. Uremia is proinflammatory and increases atherosclerosis 6- to 10-fold in apolipoprotein E-deficient mice. This study examined the effect of uremia on lipoproteins, vascular inflammation, and atherosclerosis in wild...... in cholic acid-fed sham mice. The results suggest that moderate uremia neither induces aortic inflammation nor atherosclerosis in C57BL/6J mice despite increased LDL/HDL cholesterol ratio and altered HDL composition....

  4. Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)–deficient mice

    OpenAIRE

    Miettinen, Helena E.; Rayburn, Helen; Krieger, Monty

    2001-01-01

    Mammalian female fertility depends on complex interactions between the ovary and the extraovarian environment (e.g., the hypothalamic-hypophyseal ovarian axis). The role of plasma lipoproteins in fertility was examined using HDL-receptor SR-BI knockout (KO) mice. SR-BI KO females have abnormal HDLs, ovulate dysfunctional oocytes, and are infertile. Fertility was restored when the structure and/or quantity of abnormal HDL was altered by inactivating the apoAI gene or administering the choleste...

  5. O papel do professor junto ao aluno com Altas Habilidades

    Directory of Open Access Journals (Sweden)

    Andréia Jaqueline Devalle Rech

    2012-03-01

    Full Text Available .Quando se discute a Educação Especial é comum, num primeiro momento, lembrar do aluno que compõe o especial na Educação como aquele com deficiência mental, auditiva, visual ou física. No entanto, assim como essas crianças, também os alunos com altas habilidades necessitam de um atendimento especializado, pois ele também é um sujeito da Educação Especial. Nesse sentido, este artigo apresenta a definição de altas habilidades, baseada na teoria de um pesquisador norte-americano e, como foco principal algumas questões que envolvem o professor de forma mais direta com o aluno com altas habilidades em sala de aula. Entre elas estão: questões sobre a aprendizagem escolar desses alunos, bem como os fatores que fazem parte desse processo, estratégias de ensino e a importância da identificação dos alunos com altas habilidades.Palavras-chave: Educação Especial. Professor. Aluno com Altas Habilidades

  6. Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

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    Andriy L. Zagayko

    2013-01-01

    Full Text Available HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from “Enoant” obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON and lecithin:cholesterol acyltransferase (LCAT activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After “Enoant” administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats.

  7. High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease

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    Protasio Lemos da Luz

    2008-01-01

    Full Text Available An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c indicates an atherogenic lipid profile and a risk for the development of coronary disease. OBJECTIVE: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease. METHODS: High-risk patients (n = 374 submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index. RESULTS: The subjects consisted of 220 males and 154 females, age 57.2 ± 11.1 years, with total cholesterol of 210± 50.3 mg/dL, triglycerides of 173.8 ± 169.8 mg/dL, HDL-cholesterol (HDL-c of 40.1 ± 12.8 mg/dL, LDL-cholesterol (LDL-c of 137.3 ± 46.2 mg/dL, TG/HDL-c of 5.1 ± 5.3, and a Friesinger index of 6.6 ± 4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31-3.1; p = 0.0018; HDL-c, odds ratio of 2.21 (1.42-3.43; p = 0.0005; and TG/HDL-c, odds ratio of 2.01(1.30-3.09; p = 0.0018. However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p = 0.33] or LDL-c [1.47 (0.96-2.25; p = 0.0842]. The chi-square for linear trends for Friesinger > 4 and lipid quartiles was statistically significant for triglycerides (p = 0.0017, HDL-c (p = 0.0001, and TG/HDL-c (p = 0.0018, but not for total cholesterol (p = 0.393 or LDL-c (p = 0.0568. The multivariate analysis by logistic regression OR gave 1.3 ± 0.79 (p = .0001 for TG/HDL-c, 0.779 ± 0.074 (p = .0001 for HDL-c, and 1.234 ± 0.097 (p = 0.03 for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease. CONCLUSIONS: Although some lipid variables were associated with the extent of

  8. Hubungan Kadar LDL dan HDL Serum Ibu Hamil Aterm dengan Berat Lahir Bayi

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    Oktalia Sabrida

    2014-09-01

    Full Text Available AbstrakAda anyak penelitian yang membuktikan transfer kolesterol dari ibu ke janin melalui lapisan trofoblas yang membawa partikel LDL (Low Density Lipoprotein dan HDL (High Density Lipoprotein. Pengambilan dan pemanfaatan LDL oleh plasenta merupakan mekanisme alternatif oleh janin untuk memperoleh asam lemak dan asam amino esensial. Tujuan penelitian ini untuk mengetahui hubungan kadar LDL dan HDL serum ibu hamil aterm dengan berat lahir bayi. Penelitian ini merupakan studi observasional dengan rancangan cross sectional. Dilakukan pemeriksaan kadar LDL dan HDL serum terhadap 31 sampel ibu hamil aterm yang dipilih secara consecutive sampling, kemudiaan saat bayi dari sampel lahir dilakukan penimbangan berat lahir bayi dalam 1 jam setelah lahir dengan keadaan tanpa pakaian. Data dianalisis menggunakan uji korelasi Pearson dilanjutkan dengan uji regresi linier sederhana, nilai p<0.05 dianggap bermakna secara statistik. Rerata kadar LDL serum ibu hamil aterm 138,52±37,86 mg/dl dengan 7 sampel (22,60% kadar LDL <101 mg/dl. Rerata kadar HDL serum ibu hamil aterm 53,32±17,39 mg/dl dengan 13 sampel (41,90% kadar HDL <48 mg/dl. Rerata berat lahir bayi 3150,00±489,89 gram dengan 2 sampel (6,50% memiliki bayi dengan berat<2500 gram. Terdapat hubungan positif antara kadar LDL serum ibu hamil aterm dengan berat lahir bayi, kekuatan hubungan lemah (r=0,258, secara statistik tidak bermakna (p=0,161. Terdapat hubungan positif antara kadar HDL serum ibu hamil aterm, kekuatan hubungan sangat lemah (r=0,035, secara statistik tidak bermakna (p=0,850. Kesimpulan penelitian tidak terdapat hubungan kadar LDL dan HDL serum ibu hamil dengan berat lahir bayi.Kata kunci: kadar LDL serum, kadar HDL serum, ibu hamil aterm, berat lahir bayiAbstractMany studies proved that the transferring of cholesterol from mother to fetus through the trophoblastic layer carried LDL (Low Density Lipoprotein and HDL (High Density Lipoprotein particles. Uptake and usage of LDL by placenta

  9. Perbedaan Rasio Kolesterol Total/ HDL Kelompok Kontrol dan Kelompok Diet Tinggi Minyak Sawit pada Tikus Wistar

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    Yelsa Yulanda Putri

    2014-09-01

    Full Text Available AbstrakRasio kolesterol total/ HDL merupakan variabel lipoprotein terbaik dalam memprediksi risiko penyakit kardiovaskular. Peningkatan risiko penyakit kardiovaskular dapat disebabkan oleh tingginya kadar kolesterol serum. Minyak sawit mengandung 50% asam lemak jenuh dan 50% asam lemak tidak jenuh. Tujuan penelitian ini adalah mengetahui perbedaan rasio kolesterol total/ HDL antara kelompok kontrol dengan kelompok diet tinggi minyak sawit pada tikus. Penelitian ini adalah eksperimental dengan pendekatan post test only control group design. Sampel penelitian terdiri dari 10 ekor tikus Wistar jantan yang dibagi menjadi kelompok kontrol (K dan kelompok perlakuan (P. Diet tinggi minyak sawit (minyak sawit 42.5%, 3ml/hari diberikan pada kelompok P selama empat minggu. Analisis data menggunakan uji t independent. Hasil penelitian menunjukkan terdapat perbedaan peningkatan yang tidak bermakna antara kelompok P dan kelompok K pada rerata kolesterol, yaitu 63.66±9.9(P 57.39±3.28(K (p>0.05, rerata HDL 19.44±3.99(P 17.64±2.00(K (p>0.05, dan rerata rasio kolesterol total/ HDL 3.26±0.24 (P 3.31±0.32 (K (p>0.05. Kesimpulan penelitian ini adalah kadar kolesterol total, HDL, dan rasio kolesterol total/ HDL pada kelompok kontrol dan kelompok diet tinggi minyak sawit tidak berbeda.Kata kunci: diet tinggi minyak sawit, kolesterol, HDL, rasio kolesterol/ HDLAbstractThe ratio of total cholesterol/ HDL is the lipoprotein variables best predict the risk of cardiovascular disease . The increased risk of cardiovascular disease can be caused by high levels of cholesterol exciting. Palm oil contains 50% saturated fatty acids and 50% unsaturated fatty acids. The purpose of this study was to know the differences ratio of total cholesterol/ HDL between the control group and high palm oil diet group in rats. This research was experimental with post-test only control group. The study sample consisted of 10 male Wistar rats were divided into control group (K and treated

  10. Metodologia para estudo do volume e densidade absoluta da placenta humana de termo

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    Del Nero Ulisses

    2002-01-01

    Full Text Available OBJETIVO: comparar duas metodologias para o cálculo do volume placentário em gestações normais de termo: a do princípio de Arquimedes e a do volume do cilindro, para estimar a densidade absoluta da placenta. Definir a metodologia mais adequada para o cálculo do volume e densidade placentários, que se relacione com o peso e classificação do recém-nascido. MÉTODOS: foram estudadas 50 placentas provenientes de gestações de termo sem complicações e calculados o volume e a densidade absoluta placentários: a pelo princípio de Arquimedes e b na suposição de que a placenta seria uma secção de cilindro com duas alturas diferentes do bolo placentário: com a altura média e com a altura da média aritmética do centro e extremidades. As densidades absolutas placentárias foram calculadas pelo quociente entre o peso ao ar da placenta e os diferentes volumes. RESULTADOS: a maioria das gestantes eram multíparas, idade média de 25,4 anos, volume placentário médio entre 547,8 e 610 cmsuperscript three e densidade média entre 0,94 e 1,14 g/cmsuperscript three, dependendo da metodologia empregada. CONCLUSÕES: a metodologia mais adequada para estimar o volume placentário no termo foi a do princípio de Arquimedes, pela melhor correlação com o peso dos recém-nascidos, o índice placentário e a classificação do peso dos recém-nascidos em relação à idade gestacional.

  11. Densidade microvascular no carcinoma de língua Microvascular density in carcinoma of the tongue

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    ALI AMAR

    2002-09-01

    Full Text Available OBJETIVO: Avaliar a densidade microvascular no carcinoma epidermóide de língua oral, no sítio primário e em suas metástases linfáticas. MÉTODOS: Foram avaliados retrospectivamente 30 pacientes com carcinoma epidermóide restrito à língua oral, submetidos a tratamento cirúrgico incluindo esvaziamento cervical. A densidade microvascular foi avaliada por imunohistoquímica empregando o anticorpo anti-CD34 e quantificada à microscopia óptica, no tumor primário e em suas metástases linfonodais. Foi avaliada a relação entre a densidade microvascular, as variáveis clínicas e histológicas e o prognóstico. RESULTADOS: A densidade microvascular apresentou mediana de 15,4 vasos/campo (5,5 a 25,3 nos tumores primários e 16,4 vasos/campo (12 a 32,2 nas metástases linfáticas. Foi observada uma relação inversa entre a densidade microvascular no tumor primário e na respectiva metástase linfática (r= -0,68 e p=0,04. A densidade microvascular não apresentou relação com outras variáveis histológicas ou com o prognóstico. CONCLUSÃO: Há Uma relação inversa entre a densidade microvascular no sítio primário e na metástase linfonodal, sugerindo um controle regional ou sistêmico da angiogênese.BACKGROUND. Assessment of microvascular density in squamous cell carcinoma of the oral tongue (primary lesion and metastasis. METHODS. Immunohistochemical analysis by anti CD-34 of neoangiogenesis density and its relation with clinical and histological data concerning the prognosis. After optic microscopy amplification, the relation between microvascular density, clinico-histological data and prognosis, was established. RESULTS. The microvascular density presented 15.4 vessels/field (5.5 to 25.3 in primary tumors and 16.4 vessels/field (12 to 32.2 in lymph node metastases. It was observed an inverse relation between microvascular density in primary lesions and their lymph node metastasis (r= -0.68 and p=0,04. CONCLUSIONS. No evidence was

  12. High intensity Discharge lighting; Alumbrado de alta intensidad de descarga

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza E, Ernesto J. [Manufacturera de Reactores, S. A., Mexico, D. F. (Mexico)

    1993-12-31

    This paper gets into contact with some fundamentals in the operation of high discharge intensity lamps. There are useful definitions, as well as the study of the operation of high pressure sodium lamps and of metallic additives operating at less than nominal power. [Espanol] Este trabajo pone al lector en contacto con algunos fundamentos de la operacion de las lamparas de alta intensidad de descarga (HID). Se encuentra con definiciones utiles, asi como el estudio de la operacion de las lamparas de sodio en alta presion y de aditivos metalicos operando a una potencia menor que la nominal.

  13. Cócs. Hallmark of the Terra Alta

    OpenAIRE

    Maria Del Loreto Meix

    2004-01-01

    This article looks at the traditional cake making in the Terra Alta (Catalonien) area linked to festivities, and in particular the pastries usually made. In this area the pastries are known as cócs, a word common to Terra Alta and the neighbouring districts of Ribera d'Ebre and the Priorat. Locally produced mistelle, sweet or rancid wine is served with the pastries. Nowadays, the bakeries and cake makers in the area's towns and villages also produce traditionally crafted products, tha...

  14. Enriquecimiento curricular para el alumnado con altas capacidades en primaria

    OpenAIRE

    Boldú Caballero, Tomás

    2013-01-01

    La finalidad de este documento es proporcionar al lector, primero, una rápida ojeada a la trayectoria histórica de la atención a las NEE (más concretamente de las altas capacidades); segundo, una conceptualización de las altas capacidades y sus necesidades educativas específicas tomando como punto de referencia algunos de lo más eminentes autores y corrientes psicopedagógicas actuales o del pasado reciente; y por último, facilitar ejemplos prácticos desde la perspectiva del doc...

  15. Rendimiento de plantas de tomate injertadas y efecto de la densidad de tallos en el sistema hidropónico Yield of tomato crop as a result of grafting and shoot density in hydroponic system

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    Roberta M.N. Peil

    2004-06-01

    Full Text Available El cultivo de tomate en primavera con baja densidad inicial de plantas y luego aumentar-se la densidad efectiva mediante el desarrollo de tallos laterales, cuando las integrales diarias de radiación son altas, parece ser una manera prometedora de incrementar el número de frutos m-2 y uniformizar el tamaño del fruto; y presenta la ventaja adicional de requerir-se un menor número de plantas para la superficie de cultivo. Por lo tanto, se ha llevado a cabo un ensayo cuyo objetivo ha sido evaluar los efectos de la densidad de tallos sobre el rendimiento y la uniformidad de los frutos de un cultivo de tomate injertado y no injertado. El cultivo se realizó de marzo a julio de 1998, en las condiciones de invernadero en Almería (sudeste español. La densidad inicial de plantación fue de 2,4 y 3,0 plantas m-2, en el caso de las plantas no injertadas, que presentaban un único tallo en el transplante; y 1,2 plantas m-2 en las plantas injertadas, que tenían dos tallos (2,4 tallos m-2. A partir del mes de abril, mediante el desarrollo de tallos laterales (cuando el tratamiento así lo exigía se pasó a tener las siguientes densidades: 2,4; 3,0 y 3,5 tallos m-2 (plantas injertadas y no injertadas; y 3,0 plantas no injertadas m-2 a un tallo durante todo el ciclo. Los resultados muestran que plantas de tomate injertadas y transplantadas a dos tallos tuvieron igual producción total, pero frutos de tamaño más uniforme, que plantas no injertadas transplantadas a un tallo y con doble densidad de plantas. Dentro del rango de 2,4 a 3,5 tallos m-2, una mayor densidad de tallos aumentó la producción precoz y dio un tamaño más uniforme de frutos, no afectando su peso promedio y la producción total. La adición de tallos laterales (3,0 tallos m-2 supuso una reducción de un 20% en el rendimiento total, pero vino acompañada por un ahorro de un 21% y de un 39% en el número de plantas no injertadas e injertadas, respectivamente, necesarias para la misma

  16. Differences in the triglyceride to HDL-cholesterol ratio between Palestinian and Israeli adults.

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    Ram Weiss

    Full Text Available AIMS: To evaluate differences in the triglyceride to HDL-cholesterol ratio (TG/HDL, thought to be a proxy measure of insulin resistance, between Palestinian and Israeli adults in view of the greater incidence of coronary heart disease and high prevalence of diabetes in Palestinian Arabs. RESEARCH METHODS: A population-based observational prevalence study of cardiovascular and diabetes risk factors in Jerusalem. Participants (968 Palestinians, 707 Israelis, sampled at ages 25-74 years underwent fasting and 2 h post-75 g oral challenge plasma glucose determinations. Metabolic risk was assessed using the surrogate index TG/HDL. Sex-specific comparisons were stratified by categories of body mass index and sex-specific waist circumference quartiles, adjusted by regression for age, glucose tolerance status and use of statins. RESULTS: Prevalence of overweight and obesity was substantially larger in Palestinians (p = 0.005. Prevalence of diabetes was 2.4 and 4 fold higher among Palestinian men and women, respectively (p<0.001. Adjusted TG/HDL was higher in Palestinians than Israelis across BMI and waist circumference categories (p<0.001 for both. Higher TG/HDL in Palestinians persisted in analyses restricted to participants with normal glucose tolerance and off statins. Notably, higher TG/HDL among Palestinians prevailed at a young age (25-44 years and in normal weight individuals of both sexes. CONCLUSIONS: Palestinians have a higher TG/HDL ratio than Israelis. Notably, this is evident also in young, healthy and normal weight participants. These findings indicate the need to study the determinants of this biomarker and other measures of insulin resistance in urban Arab populations and to focus research attention on earlier ages: childhood and prenatal stages of development.

  17. High density lipoprotein (HDL promotes glucose uptake in adipocytes and glycogen synthesis in muscle cells.

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    Qichun Zhang

    Full Text Available BACKGROUND: High density lipoprotein (HDL was reported to decrease plasma glucose and promote insulin secretion in type 2 diabetes patients. This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes and glycogen synthesis in muscle cells. METHODS AND RESULTS: Actions of HDL on glucose uptake and GLUT4 translocation were assessed with 1-[(3H]-2-deoxyglucose and plasma membrane lawn, respectively, in 3T3-L1 adipocytes. Glycogen analysis was performed with amyloglucosidase and glucose oxidase-peroxidase methods in normal and palmitate-treated L6 cells. Small interfering RNA was used to observe role of scavenger receptor type I (SR-BI in glucose uptake of HDL. Corresponding signaling molecules were detected by immunoblotting. HDL stimulated glucose uptake in a time- and concentration-dependent manner in 3T3-L1 adipocytes. GLUT4 translocation was significantly increased by HDL. Glycogen deposition got enhanced in L6 muscle cells paralleling with elevated glycogen synthase kinase3 (GSK3 phosphorylation. Meanwhile, increased phosphorylations of Akt-Ser473 and AMP activated protein kinase (AMPK α were detected in 3T3-L1 adipocytes. Glucose uptake and Akt-Ser473 activation but not AMPK-α were diminished in SR-BI knock-down 3T3-L1 cells. CONCLUSIONS: HDL stimulates glucose uptake in 3T3-L1 adipocytes through enhancing GLUT4 translocation by mechanisms involving PI3K/Akt via SR-BI and AMPK signaling pathways, and increases glycogen deposition in L6 muscle cells through promoting GSK3 phosphorylation.

  18. Genetic variants in ABCA1 promoter affect transcription activity and plasma HDL level in pigs.

    Science.gov (United States)

    Dang, Xiao-yong; Chu, Wei-wei; Shi, Heng-chuan; Yu, Shi-gang; Han, Hai-yin; Gu, Shu-Hua; Chen, Jie

    2015-01-25

    Excess accumulation of cholesterol in plasma may result in coronary artery disease. Numerous studies have demonstrated that ATP-binding cassette protein A1 (ABCA1) mediates the efflux of cholesterol and phospholipids to apolipoproteins, a process necessary for plasma high density lipoprotein (HDL) formation. Higher plasma levels of HDL are associated with lower risk for cardiovascular disease. Studies of human disease and animal models had shown that an increased hepatic ABCA1 activity relates to an enhanced plasma HDL level. In this study, we hypothesized that functional mutations in the ABCA1 promoter in pigs may affect gene transcription activity, and consequently the HDL level in plasma. The promoter region of ABCA1 was comparatively scanned by direct sequencing with pool DNA of high- and low-HDL groups (n=30 for each group). Two polymorphisms, c. - 608A>G and c. - 418T>A, were revealed with reverse allele distribution in the two groups. The two polymorphisms were completely linked and formed only G-A or A-T haplotypes when genotyped in a larger population (n=526). Furthermore, we found that the G-A/G-A genotype was associated with higher HDL and ABCA1 mRNA level than A-T/A-T genotype. Luciferase assay also revealed that G-A haplotype promoter had higher activity than A-T haplotype. Single-nucleotide mutant assay showed that c.-418T>A was the causal mutation for ABCA1 transcription activity alteration. Conclusively, we identified two completely linked SNPs in porcine ABCA1 promoter region which have influence on the plasma HDL level by altering ABCA1 gene transcriptional activity.

  19. Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China

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    Ming-hong Yao

    2016-01-01

    Full Text Available Objective: To detect the interactions between six functional polymorphisms in ABCA1 and obesity in Kazakhs with low HDL-C levels. Methods: A total of 204 patients with low HDL-C and 207 health control subjects, which were randomly selected from among 5692 adult Kazakhs, were matched for age and sex. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313. Results: (1 The genotypic and allelic frequencies of rs2515602, rs2230806 and rs4149313 were different between normal HDL-C and low HDL-C subjects, the genotypic frequency of rs2275542 was also different between normal HDL-C and low HDL-C subjects (p < 0.05; (2 the level of HDL-C (rs2515602 and rs2275542 in normal HDL-C subjects were different among the genotypes (p < 0.05; the levels of TC, LDL-C (rs2515602, rs4149313; TG (rs2515602, rs1800976, rs4149313 in low HDL-C patients were different among the genotypes (p < 0.05; (3 interactions between the rs3890182, rs2275542, rs180096, and rs4149313 polymorphisms in ABCA1 gene and obesity may be associated with low HDL-C disease; (4 the C-C-C-A-A-G, T-C-C-A-A-A, T-C-C-A-A-G, C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes were significant between the subjects with normal HDL-C and low HDL-C level (p < 0.05. Conclusions: The differences in serum lipid levels between normal HDL-C and low HDL-C subjects among Kazakhs might partly result from ABCA1 gene polymorphisms; ABCA1 gene polymorphisms may be associated with low HDL-C disease; the low HDL-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity; the C-C-C-A-A-G, T-C-C-A-A-A, and T-C-C-A-A-G haplotypes may serve as risk factors of low HDL-C disease among Kazakhs, the C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes may serve as protective factor of low HDL-C disease among Kazakhs.

  20. Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach[S

    Science.gov (United States)

    Gadkar, Kapil; Lu, James; Sahasranaman, Srikumar; Davis, John; Mazer, Norman A.; Ramanujan, Saroja

    2016-01-01

    The recent failures of cholesteryl ester transport protein inhibitor drugs to decrease CVD risk, despite raising HDL cholesterol (HDL-C) levels, suggest that pharmacologic increases in HDL-C may not always reflect elevations in reverse cholesterol transport (RCT), the process by which HDL is believed to exert its beneficial effects. HDL-modulating therapies can affect HDL properties beyond total HDL-C, including particle numbers, size, and composition, and may contribute differently to RCT and CVD risk. The lack of validated easily measurable pharmacodynamic markers to link drug effects to RCT, and ultimately to CVD risk, complicates target and compound selection and evaluation. In this work, we use a systems pharmacology model to contextualize the roles of different HDL targets in cholesterol metabolism and provide quantitative links between HDL-related measurements and the associated changes in RCT rate to support target and compound evaluation in drug development. By quantifying the amount of cholesterol removed from the periphery over the short-term, our simulations show the potential for infused HDL to treat acute CVD. For the primary prevention of CVD, our analysis suggests that the induction of ApoA-I synthesis may be a more viable approach, due to the long-term increase in RCT rate. PMID:26522778

  1. Características del alumnado con altas capcidades

    OpenAIRE

    Grau Rubio, Claudia

    2012-01-01

    Se describen las características del alumnado con altas capacidades, la terminología más usual y la clasificación. Asimismo, se expone la teoría de la disincronía y los mitos relacionados con este alumnado.

  2. HDL-C 和 TG/HDL-C 比值对山东省中老年回族人胰岛素抵抗的预测价值%HDL-C and TG/HDL-C ratio to identify insulin resistance in middle-aged and older Hui ethnic population in Shandong Province

    Institute of Scientific and Technical Information of China (English)

    王川; 杨位芳; 马泽强; 陈丽; 侯新国; 梁凯; 闫飞; 杨俊鹏; 王令舒; 田萌; 李成乔; 张秀萍

    2014-01-01

    Objective To find a surrogate marker to identify insulin resistance ( IR) in middle-aged and older Hui ethnic subjects in Shandong Province of China using biochemical indicators.Methods A total of 95 men and 104 women were included in the cross-sectional study.Fasting blood samples were collected to detect blood glucose, insulin, liver enzymes and lipid profiles.IR cut-off value was 3.06 as determined using the 75th percentile of HOMA-IR values.The areas under the curve ( AUC) of the receiver operating characteristic curves ( ROC) were used to compare the power of the potential markers.Results Compared with other biochemical indicators, 1/HDL-C ratio and TG/HDL-C ratio discriminated IR much better than others, with the values of AUC being 0.720 (95% CI:0.642-0.798) and 0.710(95% CI:0.634-0.786), respectively.The optimal cut-off points to identify IR were 0.702 (sensitivity 69.4%, specificity 67.3%) for 1/HDL-C ratio (1.425 mmol/L for HDL-C) and 1.043 ( sensitivity 65.3%, specificity 66.7%) for TG/HDL-C ratio. Conclusion HDL-C and TG/HDL-C ratio can easily identify IR in the urban middle-aged and older Hui ethnic popula-tion in Shandong Province.%目的:利用临床常用的生化指标,寻找可以预测山东省中老年回族人胰岛素抵抗( IR)的替代标志物。方法本横断面研究共入选95名男性和104名女性中老年回族人。采集患者空腹血样检测血糖、胰岛素、肝酶和血脂水平。以稳态胰岛素评价指数( HOMA-IR)评价人群IR状态,并以该指数的最高四分位数作为IR的切点,其数值为3.06。利用受试者工作特征曲线(ROC)的曲线下面积(AUC)评估潜在指标对IR的预测价值。结果在所有研究指标中,1/HDL-C比值和TG/HDL-C比值可以更好地预测人群的IR状态,其AUC值分别为0.720(95%CI:0.642~0.798)和0.710(95%CI:0.634~0.786)。1/HDL-C比值及TG/HDL-C比值预测IR的最佳切点分别为0.702

  3. Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size.

    Science.gov (United States)

    Kempen, Herman J; Schranz, Dorota B; Asztalos, Bela F; Otvos, James; Jeyarajah, Elias; Drazul-Schrader, Denise; Collins, Heidi L; Adelman, Steven J; Wijngaard, Peter L J

    2014-01-01

    MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high density lipoprotein (prebeta-1 HDL) and on HDL size assessed by proton nuclear magnetic resonance ((1)H-NMR). MDCO-216 incubated in buffer containing 4% human serum albumin stimulated both ABCA1-mediated efflux and ABCA1-independent cholesterol efflux from J774 macrophages. When incubated with human serum a dose- and time-dependent synergistic increase of the ABCA1-mediated efflux capacity were observed. Using a commercially available ELISA for prebeta-1 HDL, MDCO-216 as such was poorly detected (12-15% of nominal amount of protein). Prebeta-1 HDL was rapidly lost when human plasma alone is incubated at 37°C. In contrast, incubation of human plasma with MDCO-216 at 37°C produced a large amount of new prebeta-1 HDL. Native 2D electrophoresis followed by immunoblotting with an apoA-I antibody, which also detects ApoA-I Milano, confirmed the increase in prebeta-1 HDL upon incubation at 37°C. With the increase of prebeta-1 HDL, the concomitant disappearance of the small alpha-3 and alpha-4 HDL and MDCO-216 and an increase in the large alpha-1 and alpha-2 HDL were observed. Immunoblotting with Mab 17F3 specific for ApoA-I Milano showed the appearance of ApoA-I Milano in alpha-1 and alpha-2, but not in prebeta-1 HDL. (1)H-NMR analysis of plasma incubated with MDCO-216 confirmed rapid disappearance of small-sized HDL particles and increase of medium- and large-sized HDL particles accompanied with a decrease in total HDL particle number. In conclusion, incubation of human plasma or serum with MDCO-216 strongly enhanced ABCA1-mediated cholesterol efflux, caused a strong increase of prebeta-1 HDL, and drastically changed the distribution of HDL subpopulations. Overall, the

  4. Incubation of MDCO-216 (ApoA-IMilano/POPC with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

    Directory of Open Access Journals (Sweden)

    Herman J. Kempen

    2014-01-01

    Full Text Available MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC, previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high density lipoprotein (prebeta-1 HDL and on HDL size assessed by proton nuclear magnetic resonance (1H-NMR. MDCO-216 incubated in buffer containing 4% human serum albumin stimulated both ABCA1-mediated efflux and ABCA1-independent cholesterol efflux from J774 macrophages. When incubated with human serum a dose- and time-dependent synergistic increase of the ABCA1-mediated efflux capacity were observed. Using a commercially available ELISA for prebeta-1 HDL, MDCO-216 as such was poorly detected (12–15% of nominal amount of protein. Prebeta-1 HDL was rapidly lost when human plasma alone is incubated at 37°C. In contrast, incubation of human plasma with MDCO-216 at 37°C produced a large amount of new prebeta-1 HDL. Native 2D electrophoresis followed by immunoblotting with an apoA-I antibody, which also detects ApoA-I Milano, confirmed the increase in prebeta-1 HDL upon incubation at 37°C. With the increase of prebeta-1 HDL, the concomitant disappearance of the small alpha-3 and alpha-4 HDL and MDCO-216 and an increase in the large alpha-1 and alpha-2 HDL were observed. Immunoblotting with Mab 17F3 specific for ApoA-I Milano showed the appearance of ApoA-I Milano in alpha-1 and alpha-2, but not in prebeta-1 HDL. 1H-NMR analysis of plasma incubated with MDCO-216 confirmed rapid disappearance of small-sized HDL particles and increase of medium- and large-sized HDL particles accompanied with a decrease in total HDL particle number. In conclusion, incubation of human plasma or serum with MDCO-216 strongly enhanced ABCA1-mediated cholesterol efflux, caused a strong increase of prebeta-1 HDL, and drastically changed the distribution of HDL subpopulations

  5. Parâmetros sangüíneos de pacu Piaractus mesopotamicus (Holmberg, 1887 alimentados com dietas suplementadas com cromo trivalente em duas densidades de estocagem = Hematological parameters of pacu Piaractus mesopotamicus (Holmberg, 1887 fed diets supplemented with trivalent chromium in two stocking densities

    Directory of Open Access Journals (Sweden)

    Rodrigo Yudi Fujimoto

    2007-10-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos da suplementação com cromo trivalente (0, 6, 12 e 18 mg kg-1 de ração sobre as variáveis hematológicas de Piaractus mesopotamicus, mantidos em duas densidades de estocagem (4 e 20 kg m-3. Os mantidos na maior densidade e alimentados com dietas suplementadas com 0 e 6 mg de cromo kg-1apresentaram redução do número de linfócitos circulantes, sugerindo má adaptação a essa condição de alta densidade. Nas dietas suplementadas com 12 e 18 mg kg-1, tal efeito não foi observado, porém verificou-se aumento do número de trombócitos no tratamento com 12 mg de cromo kg-1. A inexistência de diferença significativa entre os tratamentos, aos 30 dias, sugere a adaptação dos peixes ao tipo de alimento e à situação de alta densidade. Portanto, nas condições deste ensaio, a suplementação com 12 e 18 mg de cromo kg-1 é interessante como estratégia alimentar durante 15 dias.This work evaluated the effects of chromium supplementation on thehematological parameters of Piaractus mesopotamicus Holmberg, 1887 maintained in two stocking densities. Fish were fed diets supplemented with 0, 6, 12 and 18 mg trivalent chromium kg-1 dry ration and maintained at 4 and 20 kg m-3. The fish under high stockingdensity and fed diets supplemented with 0 and 6 mg kg-1 showed reduction in the number lymphocytes, which suggests non-adaptation to this condition of high density. This was not observed in fish fed diets supplemented with 12 and 18 mg chromium kg-1, but an increasein the number of thrombocytes was evident. The lack of difference between treatments after 30 days may suggest a possible adaptation of fish to the situation. It can be added that supplementation with 12 and 18 mg chromium kg-1 is an interesting feeding strategy for aperiod of 15 days.

  6. The LDL-HDL profile determines the risk of atherosclerosis: a mathematical model.

    Directory of Open Access Journals (Sweden)

    Wenrui Hao

    Full Text Available Atherosclerosis, the leading death in the United State, is a disease in which a plaque builds up inside the arteries. As the plaque continues to grow, the shear force of the blood flow through the decreasing cross section of the lumen increases. This force may eventually cause rupture of the plaque, resulting in the formation of thrombus, and possibly heart attack. It has long been recognized that the formation of a plaque relates to the cholesterol concentration in the blood. For example, individuals with LDL above 190 mg/dL and HDL below 40 mg/dL are at high risk, while individuals with LDL below 100 mg/dL and HDL above 50 mg/dL are at no risk. In this paper, we developed a mathematical model of the formation of a plaque, which includes the following key variables: LDL and HDL, free radicals and oxidized LDL, MMP and TIMP, cytockines: MCP-1, IFN-γ, IL-12 and PDGF, and cells: macrophages, foam cells, T cells and smooth muscle cells. The model is given by a system of partial differential equations with in evolving plaque. Simulations of the model show how the combination of the concentrations of LDL and HDL in the blood determine whether a plaque will grow or disappear. More precisely, we create a map, showing the risk of plaque development for any pair of values (LDL,HDL.

  7. Combination of estrogen replacement and exercise protects against HDL oxidation in post-menopausal women.

    Science.gov (United States)

    Lawler, J M; Hu, Z; Green, J S; Crouse, S F; Grandjean, P W; Bounds, R G

    2002-10-01

    The incidence of atherosclerosis and cardiovascular disease (CVD) in women increases following menopause and has been associated with a reduction in circulating estrogen. Increased CVD risk is also perpetuated by sedentary lifestyle. Growing evidence indicates that oxidation of lipoproteins leads to a powerful immune response, disruption of normal lipoprotein function, and deposition of atherosclerotic plaques. For example, once high-density lipoproteins (HDL) are oxidized, they lose the ability to a) participate in reverse transport of cholesterol to the liver, and b) protect low-density lipoproteins (LDL) against oxidation. The purpose of this study was to determine the effects of combining estrogen replacement and exercise upon lipid peroxidation of the HDL fraction (HDL-ox). Blood samples were drawn from 34 post-menopausal women from four groups: women who were not receiving estrogen replacement and who were sedentary (NSD) (n = 9); women who were not receiving estrogen replacement and who were participating in regular exercise (NEX) (n = 8); women who were receiving estrogen replacement and who were sedentary (ESD) (n = 8); and women who were receiving estrogen replacement and who were participating in regular exercise (EEX) (n = 9). Total-HDL cholesterol was significantly higher (pexercise in post-menopausal women may be most effective in reducing oxidation of HDL in vivo.

  8. Densidade de plantio, crescimento, produtividade e qualidade das frutas de morangueiro "Camino Real" em hidroponia

    Directory of Open Access Journals (Sweden)

    Isabelita Pereira Portela

    2012-09-01

    Full Text Available Com o objetivo de determinar o efeito da densidade de plantio sobre o crescimento da planta, a produtividade e características químicas relacionadas à qualidade organoléptica das frutas da cultivar de morangueiro Camino Real em sistema hidropônico do tipo NFT, diferentes densidades de plantio foram avaliadas: 15,0; 12,5; 10,7 e 9,3 plantas m-2, correspondentes ao espaçamento entre plantas de 0,25; 0,30; 0,35 e 0,40 m, sendo fixado o espaçamento entre linhas de 0,18 m. O sistema NFT foi constituído por bancadas de telhas de fibrocimento de 1,10 x 2,44 m, considerando-se cada ondulação côncava da telha como um canal de cultivo. O transplante foi realizado em 26-04-2010, encerrando-se o experimento em 05-01-2011. Avaliaram-se a matéria fresca e seca de folhas, coroa, raízes e frutas, a área foliar, o número de frutas e o peso médio das frutas. Amostras das frutas foram analisadas em relação ao teor de sólidos solúveis totais (SST e à acidez total titulável (ATT. Com base nos resultados obtidos, conclui-se que o crescimento e a produtividade individual das plantas da cultivar de morangueiro Camino Real não são afetados pela elevação da densidade de plantio, no intervalo entre 9,3 e 15,0 plantas m-2. O crescimento e a produtividade por unidade de área, bem como a concentração de sólidos solúveis totais e a relação SST/ATT apresentam resposta linear ao incremento da densidade de plantio. Sugere-se a adoção da densidade de 12,5 plantas m-2, que proporcionaria rendimento mais elevado (2,79 kg m-2 de frutas com adequadas características organolépticas e redução no número de mudas necessárias, em relação à densidade de 15,0 plantas m-2. Existe a necessidade de desenvolver estudos adicionais com a cultivar Camino Real, a fim de promover adaptações no sistema e verificar a viabilidade econômica de seu cultivo em hidroponia.

  9. A tomografia computadorizada de alta resolução na avaliação da toxicidade pulmonar por amiodarona High-resolution computed tomography of amiodarone pulmonary toxicity

    Directory of Open Access Journals (Sweden)

    Daniela Peixoto Consídera

    2006-04-01

    Full Text Available OBJETIVO: Avaliar as principais alterações identificadas na tomografia computadorizada de alta resolução do tórax em pacientes com toxicidade pulmonar pela amiodarona. MATERIAIS E MÉTODOS: Foram avaliadas dez tomografias computadorizadas de alta resolução de tórax de pacientes com pneumonite pela amiodarona, seis desses pacientes do sexo masculino e quatro do sexo feminino, com idade média de 73,5 anos. RESULTADOS: Os achados tomográficos mais relevantes foram opacidades lineares ou reticulares em seis casos (60%, pequenos nódulos com densidade elevada em seis casos (60%, consolidações densas em três casos (30% e aumento da densidade do parênquima hepático em cinco de oito casos em que havia estudo tomográfico do abdome superior (62,5%. CONCLUSÃO: A tomografia computadorizada de alta resolução é um exame importante na avaliação de pacientes com toxicidade pulmonar pela amiodarona, devendo ser realizada sempre que houver suspeita deste diagnóstico. O achado de espessamento de septos interlobulares associado a lesões com aumento de densidade é altamente sugestivo deste diagnóstico.OBJECTIVE: To evaluate the main findings of chest high-resolution computed tomography in patients with amiodarone pulmonary toxicity. MATERIALS AND METHODS: Ten patients - six male and four female, average age of 73.5 years - with amiodarone-induced pneumonitis have undergone chest high-resolution computed tomography. RESULTS: The most relevant tomographic findings were linear or reticular opacities in six cases (60%, small high density nodules in six cases (60%, dense consolidations in three cases (30% and increased density in the hepatic parenchyma in five of eight cases in which there was a superior abdomen CT scan (62.5%. CONCLUSION: The high-resolution computed tomography is a valuable non-invasive test for evaluating patients with amiodarone pulmonary toxicity and should always be performed when one suspects of the presence of this

  10. Investigación en materiales sometidos a altas presiones

    Directory of Open Access Journals (Sweden)

    Juan Carlos Fallas

    2010-10-01

    Full Text Available El estudio de materiales sometidos a altas presiones es un tema de profundo interés en el campo científico e ingenieril actual. Diferentes análisis experimentales permiten descubrir los efectos que esta condición genera en la estructura molecular de un determinado compuesto.La implementación de la celda de diamante para altas presiones ha revolucionado este tema en las últimas décadas, al ser una herramienta vital en el desarrollo de estas pruebas. Presiones superiores, inclusive a los 20 Gpa, pueden ser generadas con este artefacto.Adicionalmente, la posibilidad de caracterizar muestras bajo estos parámetros y la inclusión de otras variables, como altas temperaturas, ofrecen un ambiente propicio para la evaluación de materiales bajo condiciones extremas.Este artículo explica los fundamentos básicos de la ciencia de materiales a altas presiones. Aspectos relevantes acerca de la celda de diamante y de la ejecución de experimentos son tratados en diferentes apartados. Se quiere compartir los alcances que esta disciplina posee, así como diferentes resultados que se han logrado en varias aplicaciones.Investigaciones en materiales para el almacenamiento de hidrógeno y energía, así como la simulación de condiciones presentes a muy altas profundidades en la Tierra, son casos que se tomaron en cuenta para ejemplificar áreas donde existen aplicaciones sustanciales.

  11. Efeito da densidade de estocagem no desenvolvimento inicial do acará-bandeira (Pterophyllum scalare)

    OpenAIRE

    L.P. Gonçalves Júnior; S L Pereira; M.D. Matielo; P.P. Mendonça

    2013-01-01

    Avaliou-se a influência da densidade de estocagem no desenvolvimento inicial do acará-bandeira (Pterophyllum scalare). O desempenho produtivo foi avaliado pelo ganho de peso (GP), ganho de comprimento total (GCT), ganho de comprimento padrão (GCP), ganho de altura (GA), taxa de crescimento específico (TCE), taxa de desenvolvimento específico (TDE) e sobrevivência (S). Para realização do experimento, foram utilizadas 300 pós-larvas de peso médio inicial de 0,0012g, comprimento total médio de 4...

  12. Densidades de plantio na produtividade e qualidade de frutos de melancia

    OpenAIRE

    Anamaria RP Ramos; Rita de Cássia S. Dias; Carlos Alberto Aragão

    2009-01-01

    O experimento foi conduzido na Embrapa Semi-Árido em Petrolina-PE, de setembro a dezembro de 2007, para avaliar o desempenho agronômico e a qualidade dos frutos de melancia cultivadas sob diferentes densidades de plantio. Foram avaliados três espaçamentos combinados com seis cultivares de melancia, sendo duas diplóides de polpa amarela (BRS Soleil e BRS Kuarah), duas triplóides (Híbrido Triplóide CPATSA e Extasy Seedless) e duas cultivares comerciais, também diploídes e de fruto pequeno (Smil...

  13. Chorros laminares de gas con valores muy dispares de las densidades del chorro y del ambiente

    OpenAIRE

    Sánchez Sanz, Mario

    2007-01-01

    En esta tesis se analiza la estructura de chorros laminares cuya densidad es muy diferente a la del ambiente en el que descargan debido a que, bien su temperatura o bien su peso molecular, son muy distintos. El estudio se centra en valores del número de Reynolds Re moderadamente grandes en los que el chorro continua siendo esbelto y estable. En este régimen, los términos correspondientes a la difusión axial y las variaciones transversales de presión pueden despreciarse en prime...

  14. Resultados da conjuntivodacriocistorrinostomia com implante de prótese lacrimal de polietileno de baixa densidade

    OpenAIRE

    Bison Simone; Soccol Ovídio; Scarpi Marinho Jorge

    2002-01-01

    Objetivos: Estabelecer quais são as complicações pós-operatórias da conjuntivodacriocistorrinostomia (CDCR) com implante de prótese lacrimal de polietileno de baixa densidade e relacionar a etiologia da obstrução e o aparecimento destas complicações e, conseqüentemente, o sucesso pós-operatório. Métodos: Foram analisadas 35 vias lacrimais submetidas a conjuntivodacriocistorrinostomia com implante de prótese lacrimal de polietileno. Com a finalidade de estudar as possíveis relações entre as va...

  15. Relación triglicéridos/colesterol-HDL elevada y resistencia a la insulina

    OpenAIRE

    Antonio González-Chávez; Luis Ernesto Simental-Mendía; Sandra Elizondo-Argueta

    2011-01-01

    Introducción: La enfermedad cardiovascular es la principal causa de muerte en el mundo y la resistencia a la insulina desempeña un papel fundamental para su desarrollo. Además, la resistencia a la insulina se ha asociado con hipertensión arterial sistémica y síndrome metabólico, al igual que la relación riglicéridos/colesterol-HDL (TGL/HDL). Objetivo: determinar si la relación TGL/HDL está asociada con resistencia a la insulina en una población aparentemente sana. Material y métodos: Estudio ...

  16. Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects

    DEFF Research Database (Denmark)

    Plomgaard, P; Dullaart, R P F; de Vries, R;

    2009-01-01

    protein (PLTP) activity and the ability of plasma to promote cholesterol efflux from cultured fibroblasts. RESULTS: ApoM was approximately 9% lower in patients with type 2 diabetes compared to controls (0.025 +/- 0.006 vs. 0.027 +/- 0.007 g L(-1), P = 0.01). The difference in apoM was largely attributable...... 2 diabetes have reduced plasma apoM and whether apoM is associated with pre-beta-HDL formation and cellular cholesterol efflux. DESIGN: In 78 patients with type 2 diabetes and 89 control subjects, we measured plasma apoM with ELISA, pre-beta-HDL and pre-beta-HDL formation, phospholipid transfer...

  17. The usefulness of information on HDL-cholesterol: potential pitfalls of conventional assumptions

    Directory of Open Access Journals (Sweden)

    Furberg Curt D

    2001-05-01

    Full Text Available Abstract Treatment decisions related to disease prevention are often based on two conventional and related assumptions. First, an intervention-induced change in a surrogate marker (such as high-density lipoprotein [HDL]-cholesterol in the desired direction translates into health benefits (such as reduction in coronary events. Second, it is unimportant which interventions are used to alter surrogate markers, since an intervention benefit is independent of the means by which it is achieved. The scientific foundation for these assumptions has been questioned. In this commentary, the appropriateness of relying on low levels of HDL-cholesterol for treatment decisions is reviewed. The Veterans Affairs - HDL-Cholesterol Intervention Trial (VA-HIT investigators recently reported that only 23% of the gemfibrozil-induced relative reduction in risk of coronary events observed in the trial could be explained by changes in HDL-cholesterol between baseline and the 1-year visit. Thus, 77% of the health benefit to the participants was unexplained. Other possible explanations are that gemfibrozil has multiple mechanisms of action, disease manifestations are multifactorial, and laboratory measurements of HDL-cholesterol are imprecise. The wisdom of relying on levels and changes in surrogate markers such as HDL-cholesterol to make decisions about treatment choices should questioned. It seems better to rely on direct evidence of health benefits and to prescribe specific interventions that have been shown to reduce mortality and morbidity. Since extrapolations based on surrogate markers may not be in patients' best interest, the practice of medicine ought to be evidence-based.

  18. Pre-clinical evaluation of rHDL encapsulated retinoids for the treatment of Neuroblastoma

    Directory of Open Access Journals (Sweden)

    Nirupama eSabnis

    2013-03-01

    Full Text Available Despite major advances in pediatric cancer research, there has been only modest progress in the survival of children with high risk neuroblastoma (HRNB. The long term survival rates of HRNB in the United States are still only 30-50%. Due to resistance that often develops during therapy, development of new effective strategies is essential to improve the survival and overcome the tendency of HRNB patients to relapse subsequent to initial treatment. Current chemotherapy regimens also have a serious limitation due to off target toxicity. In the present work, we evaluated the potential application of reconstituted high density lipoprotein (rHDL containing fenretinide (FR nanoparticles as a novel approach to current neuroblastoma therapeutics. The characterization and stability studies of rHDL-FR nanoparticles showed small size (<40nm and high encapsulation efficiency. The cytotoxicity studies of free FR vs. rHDL/ FR towards the neuroblastoma cell lines SK-N-SH and SMS-KCNR showed 2.8 and 2 fold lower IC50 values for the rHDL encapsulated FR vs. free FR. More importantly, the IC50 value for retinal pigment epithelial cells (ARPE-19, a recipient of off target toxicity during FR therapy, was over 40 times higher for the rHDL/ FR as compared to that of free FR. The overall improvement in in vitro selective therapeutic efficiency was thus about 100 fold upon encapsulation of the drug into the rHDL nanoparticles. These studies support the potential value of this novel drug delivery platform for treating pediatric cancers in general, and neuroblastoma in particular

  19. Low HDL cholesterol is associated with lower gray matter volume in cognitively healthy adults

    Directory of Open Access Journals (Sweden)

    Michael A Ward

    2010-07-01

    Full Text Available Dyslipidemia is common in adults and contributes to high rates of cardiovascular disease and may be linked to subsequent neurodegenerative and neurovascular diseases. This study examined whether lower brain volumes and cognition associated with dyslipidemia could be observed in cognitively healthy adults, and whether apolipoprotein E (APOE genotype or family history of Alzheimer’s disease (FHAD alters this effect. Methods: T1-weighted MRI was used to examine regional brain gray matter (GM and white matter (WM in 183 individuals (58.4 ± 8.0 years using voxel-based morphometry. A nonparametric multiple linear regression model was used to assess the effect of high-density lipoprotein (HDL and non-HDL cholesterol, APOE, and FHAD on regional GM and WM volume. A post hoc analysis was used to assess whether any significant correlations found within the volumetric analysis had an effect on cognition. Results: HDL was positively correlated with GM volume in the bilateral temporal poles, middle temporal gyri, temporo-occipital gyri, and left superior temporal gyrus and parahippocampal region. This effect was independent of APOE and FHAD. A significant association between HDL and the Brief Visuospatial Memory Test was found. Additionally, GM volume within the right middle temporal gyrus, the region most affected by HDL, was significantly associated with the Controlled Oral Word Association Test and the Center of Epidemiological Studies Depression Scale. Conclusions: These findings suggest that adults with decreased levels of HDL cholesterol may be experiencing cognitive changes and GM reductions in regions associated with neurodegenerative disease and therefore, may be at greater risk for future cognitive decline.

  20. Prosopis farcta beans increase HDL cholesterol and decrease LDL cholesterol in ostriches (Struthio camelus).

    Science.gov (United States)

    Omidi, Arash; Ansari nik, Hossein; Ghazaghi, Mahmood

    2013-02-01

    Ten blue-neck male ostriches (Struthio camelus) were fed Prosopis farcta beans throughout a 30-day experiment. Blood samples were collected from ostriches on days 0 and 30 to measure levels of high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, total serum protein, albumin, globulin, cholesterol, calcium, inorganic phosphorus, the activity of aspartate aminotransferase, alanine aminotransferase, and γ-glutamyl transferase (γ-GT). From days 0 to 30, HDL cholesterol, total protein, and globulins levels increased significantly whereas LDL cholesterol, inorganic phosphorus, and γ-GT activity decreased significantly.

  1. [Lipoproteins HDL and coronary artery disease: a molecular mechanism of fibrate].

    Science.gov (United States)

    Kaletha, Krystian; Chodorowski, Zygmunt; Anand, Izabela Sein; Rybakowska, Iwona; Nagel-Starczynowska, Gabriela

    2003-01-01

    The importance of dyslipidemia in the development of cardiovascular disease is now recognized as a central factor of equal, if not greater significance than any other risk factor. Although correction of high level of low-density lipoproteins (LDL) has been regarded now as the main goal of therapy, it has now been reaffirmed that the contribution of low level of high-density lipoproteins (HDL) to the risk of ischaemic heart disease should also be considered. In the therapy of dislipidemias with hipertriglyceridemia and decreased level of HDL lipoprotein fibrates play an especially important role. In the article the molecular mechanism of fibrates action is presented.

  2. Diel density variation of amphipods associated with Sargassum beds from two shores of Ubatuba, Southeastern, Brazil Variação ao longo do dia na densidade de anfípodos associados a bancos de Sargassum em duas praias de Ubatuba, SP, Brasil

    Directory of Open Access Journals (Sweden)

    Fosca P. P. Leite

    2007-12-01

    Full Text Available Densities of mobile epifaunal assemblages associated with macrophytes are very variable during the day and the activity of visually-oriented predators is thought to have an important influence on this pattern. Here we compared densities of amphipods associated with a common brown alga, Sargassum stenophyllum (Phaeophyceae, at sites contrasting in water turbidity. We expected that diel variation of amphipods would occur in a shore with clear waters (Perequê, whereas no variation was expected in a shore with turbid waters (Lamberto. Amphipod density varied during the day at both shores, with no indication of a larger variation at Perequê. Most species showed two density peaks, one at night and the other in the afternoon. These peaks occurred close the times of high tide, suggesting that tidal rhythms could influence more amphipod densities than the activity of predators. Thus, more studies are necessary to understand factors that influence short-term variation of epifaunal assemblages.As densidades da epifauna móvel associada a macrófitas variam muito ao longo do dia, sendo a atividade de predadores visualmente orientados um dos principais fatores apontados para explicar este padrão. Neste estudo, comparamos as densidades de anfípodos associados a uma alga parda comum, Sargassum stenophyllum (Phaeophyceae, em praias contrastando em turbidez da água. Era esperada a ocorrência de variação ao longo do dia numa praia com águas claras (Perequê e nenhuma variação na praia com águas turvas (Lamberto. A densidade de anfípodos variou ao longo do dia em ambas as praias, sem indicação de maior variação em Perequê. A maioria das espécies apresentou dois picos de densidade: um à noite e outro à tarde. Estes ocorreram próximos aos períodos de maré alta, sugerindo que o ritmo de maré poderia influenciar mais as densidades de anfípodos que a atividade de predadores. Assim, mais estudos são necessários para se compreender os fatores

  3. Densidade e diversidade fenotípica de bactérias diazotróficas não simbióticas em solos da Reserva Biológica Serra dos Toledos, Itajubá (MG

    Directory of Open Access Journals (Sweden)

    Talita Filomena Silva

    2011-04-01

    Full Text Available Bactérias diazotróficas não simbióticas (BDNS atuam no desenvolvimento das plantas por meio da fixação biológica de nitrogênio e também pela produção e liberação de substâncias reguladoras do crescimento vegetal. Este estudo objetivou avaliar a densidade e diversidade fenotípica desse grupo de bactérias em fragmentos de solo da Reserva Biológica Serra dos Toledos e entorno, em Itajubá/MG. Essa reserva localiza-se na Área de Proteção Ambiental da Mantiqueira, constituindo-se em uma importante área de recarga e de abrigo à flora e fauna endêmicas. Amostras de solo superficial foram coletadas em áreas com diferentes declividades na reserva, em épocas representativas das estações de inverno (setembro/2006 e verão (abril/2007. A densidade, avaliada pelo número mais provável, utilizando os meios de cultura NFb, JNFb e Fam, para Azospirillum spp., Herbaspirillum spp. e A. amazonense, respectivamente, variou de 0,12 a 75,60 (NMP x 10(5 bactérias g-1 solo seco. Foram obtidos 172 e 174 isolados, respectivamente para as amostras de inverno e verão, dos quais 30 e 55 % apresentaram similaridade igual ou superior a 70 % com as estirpes-tipo Azospirillum brasilense, A. amazonense, A. lipoferum, Herbaspirillum seropedicae e Burkholderia brasilensis. O resultado do comportamento dos isolados com base na tolerância à salinidade nem sempre foi semelhante ao obtido pelas características fenotípicas culturais a 70 % de similaridade, sendo indicado para estudos complementares de diversidade desses organismos. As BDNS apresentam potencial de utilização em estudos de avaliação da qualidade e sustentabilidade de ecossistemas. No entanto, apesar da alta densidade e diversidade fenotípica em solos da reserva, maiores valores foram obtidos no entorno, evidenciando o efeito positivo da cobertura vegetal do tipo gramíneas sobre elas, independentemente da variação climática.

  4. Desenvolvimento e produção da bananeira 'grande naine' sob diferentes densidades de plantio em região com ocorrência natural de sigatoka-negra

    Directory of Open Access Journals (Sweden)

    Edson Shigueaki Nomura

    2013-06-01

    Full Text Available A alta densidade de plantio de algumas cultivares de bananeira é uma prática utilizável para aumentar a produtividade, sobretudo em regiões afetadas pela Sigatoka. Este trabalho objetivou avaliar o desenvolvimento e a produção de bananeiras 'Grande Naine' cultivadas em diferentes densidades de plantio para a convivência com a Sigatoka-Negra no Vale do Ribeira-SP. Para isso, foi instalado pomar de bananeiras produzidas in vitro da 'Grande Naine', em delineamento inteiramente ao acaso, em esquema fatorial 5 x 2, sendo cinco densidades (2.500; 2.222; 2.000; 1.667 e 1.111 plantas.ha-1 e dois ciclos de produção. A severidade da Sigatoka-Negra foi monitorada semanalmente, utilizando o método de Estado da Evolução (EE e para o seu controle foram definidas pela segunda progressão consecutiva da severidade e/ou aumento superior a 200 pontos de uma semana para a outra. De cada parcela, oito plantas foram avaliadas quanto à altura, diâmetro do pseudocaule, número de folhas ativas no florescimento e na colheita, massa fresca dos frutos comercializáveis, produtividade, número de pencas e frutos no cacho, massa fresca total e por frutos da 2ª penca, comprimento e diâmetro de frutos da 2ª penca. Os dados foram submetidos à análise de variância pelo teste F, e as médias, quando significativas, foram comparadas pelo teste de Tukey (5% de probabilidade. Diante das condições experimentais, conclui-se que o adensamento não influenciou no desenvolvimento em altura da planta e no diâmetro do pseudocaule de bananeira 'Grande Naine'. O adensamento de plantas proporcionou maiores produtividades de bananeira 'Grande Naine' nas condições do Vale do Ribera-SP.

  5. El niño, oscilación del sur (ENOS, con relación a la transmisión de malaria, densidad y paridad de An. albimanus y An. darlingi (diptera: culicidae en dos regiones de Colombia

    Directory of Open Access Journals (Sweden)

    Ricardo Mantilla

    2000-02-01

    Full Text Available

    Una fuerte asociación ha sido registrada entre los incrementos en la transmisiónas forzadas por el fenómeno El Niño. Entre las posibles explicaciones para esta asociación está el efecto del clima sobre la dinámica de población de vectores, por ejemplo, generando cambios en la densidad y en las tasas de sobrevivencia de la población, y en la cantidad y calidad de sitios de reproducción, como también a través de cambios en el período de incubación extrínseco del parásito dentro del vector. Con el propósito de evaluar la influencia de ENOS sobre la densidad y paridad de Anopheles albimanus y An. darlingi, y su relación con la transmisión de malaria, se realizó un estudio longitudinal en Chocó y Casanare. En cada área se seleccionaron dos localidades y se realizaron muestreos entomológicos durante una semana cada mes, desde finales de 1997 hasta 1999. Este período cubrió los eventos El Niño 1997 -1998 y La Niña 1998 - 2000. En las localidades de Chocó se observó un importante incremento en el número de casos de malaria durante el evento ENOS, asociado con la temperatura. No se observó una asociación estadísticamente significativa entre los casos de malaria y la precipitación o la humedad relativa. La relación entre el incremento de malaria durante El Niño y las variables entomológicas no fue evidente. La densidad y paridad de ambas especies de vectores fluctuaron durante el período de estudio y no se encontró una asociación significativa entre estas variables y los factores climáticos como la temperatura. La precipitación y la humedad relativa. La densidad de larvas de An. albimanus fluctuó durante el estudio, y mostró altas densidades alrededor de julio - agosto. No se observó asociación entre la densidad de larvas con la densidad de adultos o las variables climáticas. El efecto del evento ENOS sobre las poblaciones de vectores

  6. Alta Velocità e innovazioni tecnologiche e funzionali

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    Emilia Giovanna Trifiletti

    2008-05-01

    Full Text Available La realizzazione di linee e di stazioni dell’Alta Velocità, oltre ad influire sullo sviluppo urbanistico delle aree interessate, sta cambiando radicalmente le relazioni spazio-temporali fra i diversi centri urbani connessi dalla rete del trasporto su ferro. Da un lato sono mutate le funzioni assunte dai contenitori-stazione e dall’altro sta mutando la domanda di trasporto che promuove, per le tratte coperte dalle linee dell’Alta Velocità, il treno rispetto all’aereo e alla macchina. In Italia, sulla scia del modello francese, il Gruppo Ferrovie dello Stato RFI, al fine di rendere più confortevole ed efficiente il viaggio sui treni ad Alta Velocità, ha dotato i nuovi treni di numerose innovazioni tecnologiche. Per quanto riguarda l’utilizzo di nuove tecnologie lungo le linee dell’A.V., l’articolo individua la variazione delle abitudini degli utenti al mutare dell’offerta dei servizi predisposti dalle compagnie trasportistiche. La tecnologia utilizzata sui nuovi treni dell’Alta Velocità cambia dunque il concept del viaggio: il valore aggiunto della tecnologia Wi-Fi introdotta sui treni rende la scelta del trasporto su ferro più produttiva rispetto gli altri modi di trasporto quali la macchina o l’aereo. La finalità dell’articolo è da un lato individuare il ruolo urbano assunto delle stazioni dell’Alta Velocità e dall’altro evidenziare come al mutare dell’offerta di trasporto, in termini di servizi offerti ad alto contenuto tecnologico, muta contestualmente anche la domanda di trasporto sul territorio e come tutto questo incida dunque sul governo delle trasformazioni territoriali. Questo è il nuovo importante ruolo della pianificazione: alcune delle nostre più importanti città stanno radicalmente trasformandosi proprio inserendo nei loro cuori le stazioni dell’Alta Velocità come elementi-chiave di accessibilità, vitale per la competitività in tutti i settori economici. Allo stesso modo le stazioni

  7. Serum IF1 concentration is independently associated to HDL levels and to coronary heart disease: the GENES study[S

    OpenAIRE

    Genoux, Annelise; Ruidavets, Jean-Bernard; Ferrières, Jean; Combes, Guillaume; Lichtenstein, Laeticia; Pons, Véronique; Laffargue, Muriel; Taraszkiewicz, Dorota; Carrié, Didier; Elbaz, Meyer; Perret, Bertrand; Martinez, Laurent O.

    2013-01-01

    HDL is strongly inversely related to cardiovascular risk. Hepatic HDL uptake is controlled by ecto-F1-ATPase activity, and potentially inhibited by mitochondrial inhibitor factor 1 (IF1). We recently found that IF1 is present in serum and correlates with HDL-cholesterol (HDL-C). Here, we have evaluated the relationship between circulating IF1 and plasma lipoproteins, and we determined whether IF1 concentration is associated with the risk of coronary heart disease (CHD). Serum IF1 was measured...

  8. IMPACTO DEL PASTOREO CON GANADO HOLSTEIN Y JERSEY SOBRE LA DENSIDAD APARENTE DE UN ANDISOL

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    Rodolfo WingChing-Jones

    2009-01-01

    momento del pastoreo (antes y después y potrero, fueron significativas para la cuantificación del cambio en la densidad aparente. Los valores de ¿a antes de que entrara el ganado a los apartos variaron entre 0,47 y 0,58 Mg/m3, con un promedio de 0,52 Mg/m3, mientras que después del paso del ganado variaron entre 0,52 y 0,77 Mg/m3, con un promedio de 0,64 Mg/m3. Cuando el pastoreo se realizó con ganado Jersey, la ¿a aumentó a valores entre 0,52 y 0,72 Mg/m3, con un promedio de 0,62 Mg/m3y con pastoreo de ganado Holstein entre 0,62 y 0,77 Mg/m3, con un valor promedio de 0,69 Mg/m3. El cambio en la densidad aparente producto del pisoteo en un suelo con cobertura permanente de pasto kikuyo, con las condiciones que prevalecieron durante este trabajo varió entre 14 y 31%.

  9. Evaluación de densidades de siembra en tomate (Lycopersicon esculentum Mill en invernadero

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    Jos\\u00E9 Cruz Carrillo

    2003-01-01

    Full Text Available Esta investigación se realizó de junio a diciembre del 2001 en el módulo de horticultura protegida del Instituto Tecnológico Agropecuario de Oaxaca No. 23 ubicado en la ex Hacienda de Nazareno, Xoxocotlan, Oax., con el propósito de evaluar el efecto de tres densidades de plantación en el desarrollo vegetativo y producci ón de diferentes híbridos de tomate con crecimiento indeterminado cultivados bajo invernadero. Los híbridos de tomate fueron el SXT, DRW3410 y SXT0289. No hubo diferencia estad ística para los híbridos, sólo para densidades de plantación, obteniendo los mejores rendimientos 5,3 plantas/m2 y 4 plantas/ m2 con 17,52 y 17,37 kg/m2, respectivamente, lo que represent ó en promedio un rendimiento de 151,6 t/ha.

  10. Impact of estimated HDL particle size via the ratio of HDL-C and apoprotein A-I on short-term prognosis of diabetic patients with stable coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    Li-Feng HONG; Bo YANG; Song-Hui LUO; Jian-Jun LI

    2014-01-01

    BackgroundRevascularization and statin therapy are routinely used in the management of stable coronary artery disease. However, it is unclear whether the estimated high-density lipoprotein (HDL) particle size (eHDL-S), the ratio of HDL cholesterol (HDL-C) to apoprotein A-I (apoA-I), is associated with the clinical outcomes of diabetic patients with stablecoronary artery disease (CAD).MethodsWe per-formed a prospective cohort study of 328 patients diagnosed with stable CAD by coronary angiography. Patients were followed up for a mean duration of 12 months. The patients were divided into three groups by the tertiles of eHDL-S: low eHDL-S ( 0.79,n= 99). The associations between the baseline eHDL-S and short-term out-comes were evaluated using the Kaplan-Meier method and Cox proportional regression.Results The low eHDL-S group had higher trig-lyceride, hemoglobin A1c, uric acid, and leukocyte count than the other groups. During the follow-up period, 47/328 patients experienced a pre-specified outcome. According to the Kaplan-Meier analysis, the incidence of pre-specified outcomes was lower in the high eHDL-S group (P = 0.04). However, eHDL-S was not independently associated with adverse outcomes in Cox proportional hazards regression (haz-ard ratio (HR): 0.23, 95% confidence interval (95% CI): 0.01-11.24,P = 0.493).ConclusionAlthough the eHDL-S was associated with inflammatory biomarkers, it was not independently associated with the short-term prognosis of diabetic patients with stable CAD in the era of revascularization and potent statin therapy.

  11. Caracterización de unidades biofísicas a partir de indicadores ambientales en Milpa Alta, Centro de México

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    María de Lourdes Rodríguez Gamiño

    2006-01-01

    Full Text Available En este trabajo se delimitaron y caracterizaron a las unidades biofísicas a partir de indicadores ambientales en Milpa Alta, Centro de México. Se trazaron las unidades geomorfológicas morfogenéticas que sirvieron de base para la caracterización de las unidades ambientales biofísicas (UAB. Se llevaron a cabo recorridos de campo para la verificación de las UAB y para la toma de muestras de suelos y levantamientos botánicos. En laboratorio se determinaron las propiedades físicas y químicas de los suelos. Se determinaron los indicadores de los factores de relieve, suelo, cobertura vegetal y uso de suelo. Las UAB se caracterizaron considerando los indicadores de relieve, pendiente y altitud; clima, temperatura y precipitación; suelo, humedad, materia orgánica, densidad aparente, pH; vegetación, densidad de la cobertura vegetal y uso de suelo. Las unidades se caracterizan por ser de origen endógeno volcánico acumulativo de flujos lávicos. Los tipos de relieve que predominan en los sitios muestreados son laderas de montaña superiores, medias e inferiores, de flujos lávicos; laderas de montaña superiores, internas y externas, de cono cinerítico; laderas superiores e inferiores de lomeríos medios y bajos; piedemonte acumulativo local; piedemonte acumulativo de lomeríos medios y bajos y planicie aluvial. La caracterización de las UAB mediante los indicadores ambientales permite contar con información básica para la toma de decisiones en el manejo adecuado de los recursos naturales y en la planeación socioambiental.

  12. Estructura metropolitana y funciones de densidad residencial. El caso de la región metropolitana de Barcelona

    OpenAIRE

    Muñiz, Iván; Galindo, Anna

    2006-01-01

    La relación que se establece entre el nivel de densidad residencial y la accesibilidad al lugar de empleo en el interior de una área urbana parece ser más compleja que la supuesta en el Modelo de Ciudad Monocéntrica. Las estimaciones de funciones de densidad residencial más simples, sustentadas en un modelo teórico que suponía una concentración total del empleo en el distrito central y que utilizaban como única medida de accesibilidad la distancia al centro, han dado paso a estimaciones más s...

  13. Densidad poblacional y uso del hábitat de la codorniz Moctezuma (Cyrtonyx montezumae) en Hualtepec, Hidalgo

    OpenAIRE

    Lilia Hernández Palafox; Germán David Mendoza Martínez; Juan Ignacio Valdez Hernández; José Luis Alcántara Carbajal; Fernando Clemente Sánchez; Marivel Hernández Téllez

    2007-01-01

    El presente estudio se realizó para determinar la densidad poblacional y el uso del hábitat de la codorniz Moctezuma (Cyrtonyx montezumae) en Hualtepec, Hidalgo, México, en tres tipos de vegetación: bosque, pastizal y zona de transición (ecotono). Dicho sitio se localiza en el extremo oeste de Hidalgo, con área de muestreo de 5 715 ha. Se realizó un muestreo en 55 unidades, para evaluar el uso del hábitat por medio de indicios (excretas, rascaderos, plumas y nidos), y densidad de población, c...

  14. Variaciones en la densidad del oxígeno en el aire y su influencia sobre la salud humana

    OpenAIRE

    Olcina Cantos, Jorge; Martín Estévez, David

    2012-01-01

    La falta de oxígeno puede conllevar serias consecuencias en la salud de los seres vivos, incluida la muerte. La modificación de su densidad en el aire pueda tener efectos sobre la salud humana, especialmente en grupos de riesgo y personas con afecciones pulmonares o cardiacas previas. Se analiza el efecto de las variaciones en la densidad de oxígeno, originadas por los cambios en las masas de aire presentes en la atmósfera, sobre los ingresos hospitalarios por enfermedad cardiaca y vásculo-ce...

  15. Densidad poblacional del venado cola blanca (Odocoileus virginianus) en sabana inindable de Paz De Ariporo (Casanare), Orinoquia colombiana

    OpenAIRE

    Montenegro Olga Lucía; Pérez Moreno Heidi Yohana

    2006-01-01

    Esta investigación buscó estimar y analizar las diferencias en la densidad poblacional del venado cola blanca
    (Odocoileus virginianus) en dos hatos de la Orinoquia colombiana, con miras a aportar elementos para su manejo
    sostenible en la región. Para la estimación de densidad se realizaron conteos de individuos y grupos en transectos
    lineales de ancho variable acumulando 54,3 km y 48,65 km en los hatos Taparas y Miramar respectivamente.
    Estos recorr...

  16. Estabilidad y funcionalidad de sellantes dentales en altas temperaturas ambientales

    OpenAIRE

    Mishina, Anastasia; Mayelín Guerra, Rosa; Durán Ramos, Ivette; Juan D. Sabatier

    2000-01-01

    Los sellantes dentales son materiales que se emplean en estomatología para sellar las fosas y fisuras oclusales de los dientes y evitar la adherencia del estreptococus mutans agente que produce la caries dental. Estos materiales se suministran en dos partes que al mezclarse producen el endurecimiento de la resina. Sin embargo, estos productos presentan dificultades para su comercialización en los países tropicales, debido a que las altas temperaturas ambientales traen problemas en...

  17. Luces y sombras de la lectura en voz alta

    OpenAIRE

    Cassany, Daniel

    2007-01-01

    En el siguiente artículo aborda una práctica tan extendida en las aulas de todos los niveles educativos como es la lectura en voz alta. A partir de su experiencia personal y profesional, formula un análisis ameno, provocador y fundamentado, una constante en sus textos y conferencias, que suscitará en el lector docente nuevas perspectivas acerca de su trabajo.

  18. Cócs. Hallmark of the Terra Alta

    Directory of Open Access Journals (Sweden)

    Maria Del Loreto Meix

    2004-04-01

    Full Text Available This article looks at the traditional cake making in the Terra Alta (Catalonien area linked to festivities, and in particular the pastries usually made. In this area the pastries are known as cócs, a word common to Terra Alta and the neighbouring districts of Ribera d'Ebre and the Priorat. Locally produced mistelle, sweet or rancid wine is served with the pastries. Nowadays, the bakeries and cake makers in the area's towns and villages also produce traditionally crafted products, that used only to be homemade.The article, resulting from the final degree project produced by the author for her Humanities degree at the UOC, offers a privileged look at the richness of the Terra Alta in terms of its gastronomic history, customs and its high regard for its cakes. The author, who has previous experience in the field, places the specific aspects of Terra Alta cake making in the context of the Mediterranean cultures with common roots dating back to the ancient and medieval worlds and which still have an easily identifiable "family feel", whilst looking, from an ethnographic point of view, at what she calls the "world of wheat" in the area, (the dough for bread, the craft of the baker, the ovens and other tools, and the associated traditions, among other things. In short, she rescues a living part of the local day-to-day activities and places it under the microscope of food history, whilst providing information that may well be of interest for study from other points of view.

  19. Los colosos del campo: tractores de alta potencia

    OpenAIRE

    Moya Gonzalez, Adolfo; Diezma Iglesias, Belen

    2014-01-01

    Revisión y descripción de las principales características de los tractores de alta potencia en el sector agrícola español. La agricultura profesional es una empresa compleja y la inversión en formación de los agentes implicados en el sector (agricultores e ingenieros) es la llave para conseguir aprovechar toda la tecnología disponible y optimizar los recursos usados.

  20. Cuaderno de Prácticas: Altas Capacidades

    OpenAIRE

    García Fernández, José Manuel; Vicent Juan, Maria; Gonzálvez Macià, Carolina

    2016-01-01

    Este material, centrado en el estudio de las Altas Capacidades, pretende favorecer la adquisición de destrezas en el conocimiento e intervención en el ámbito de la educación especial para conocer de primera mano las diferentes formas que se tienen para actuar e intervenir ante niños con necesidades específicas de apoyo educativo.

  1. Sex differences in HDL ApoC-III in American Indian youth

    Directory of Open Access Journals (Sweden)

    Blackett Piers R

    2012-08-01

    Full Text Available Abstract Background Since American Indians are predisposed to type 2 diabetes (DM2 and associated cardiovascular risk, Cherokee boys and girls (n = 917 were studied to determine whether BMI Z (body mass index Z score is associated with the apoC-III (apolipoprotein C-III content of HDL (high density lipoprotein, a previously reported predictor of DM2. Methods An ad hoc cross-sectional analysis was conducted on a previously studied cohort. Participants were grouped by gender-specific age groups (5 to 9, 10 to 14 and 15 to 19 years. ApoA-I (apolipoprotein A-I and HDL apoC-III were assayed by electroimmunoassay. ApoC-III was measured in whole plasma, and in HDL to determine the molar proportion to apoA-I. General linear models were used to assess association. Results The HDL apoC-III to apoA-I molar ratio increased by BMI Z quartile in girls aged 10–14 years (p  Conclusions ApoC-III showed an obesity-related increase relative to apoA-I during adolescence beginning in girls aged 10 to 14 years and in boys aged 15 to 19 years. The earlier changes in girls may alter HDL’s protective properties on the β-cell and contribute to their increased risk for DM2.

  2. Plasma HDL cholesterol and risk of myocardial infarction : A mendelian randomisation study

    NARCIS (Netherlands)

    Voight, Benjamin F.; Peloso, Gina M.; Orho-Melander, Marju; Frikke-Schmidt, Ruth; Barbalic, Maja; Jensen, Majken K.; Hindy, George; Holm, Hilma; Ding, Eric L.; Johnson, Toby; Schunkert, Heribert; Samani, Nilesh J.; Clarke, Robert; Hopewell, Jemma C.; Thompson, John F.; Li, Mingyao; Thorleifsson, Gudmar; Newton-Cheh, Christopher; Musunuru, Kiran; Pirruccello, James P.; Saleheen, Danish; Chen, Li; Stewart, Alexandre F. R.; Schillert, Arne; Thorsteinsdottir, Unnur; Thorgeirsson, Gudmundur; Anand, Sonia; Engert, James C.; Morgan, Thomas; Spertus, John; Stoll, Monika; Berger, Klaus; Martinelli, Nicola; Girelli, Domenico; McKeown, Pascal P.; Patterson, Christopher C.; Epstein, Stephen E.; Devaney, Joseph; Burnett, Mary-Susan; Mooser, Vincent; Ripatti, Samuli; Surakka, Ida; Nieminen, Markku S.; Sinisalo, Juha; Lokki, Marja-Liisa; Perola, Markus; Havulinna, Aki; de Faire, Ulf; Gigante, Bruna; Ingelsson, Erik; Zeller, Tanja; Wild, Philipp; de Bakker, Paul I. W.; Klungel, Olaf H.; Maitland-van der Zee, Anke-Hilse; Peters, Bas J. M.; de Boer, Anthonius; Grobbee, Diederick E.; Kamphuisen, Pieter W.; Deneer, Vera H. M.; Elbers, Clara C.; Onland-Moret, N. Charlotte; Hofker, Marten H.; Wijmenga, Cisca; Verschuren, W. M. Monique; Boer, Jolanda M. A.; van der Schouw, Yvonne T.; Rasheed, Asif; Frossard, Philippe; Demissie, Serkalem; Willer, Cristen; Do, Ron; Ordovas, Jose M.; Abecasis, Goncalo R.; Boehnke, Michael; Mohlke, Karen L.; Daly, Mark J.; Guiducci, Candace; Burtt, Noel P.; Surti, Aarti; Gonzalez, Elena; Purcell, Shaun; Gabriel, Stacey; Marrugat, Jaume; Peden, John; Erdmann, Jeanette; Diemert, Patrick; Willenborg, Christina; Koenig, Inke R.; Fischer, Marcus; Hengstenberg, Christian; Ziegler, Andreas; Buysschaert, Ian; Lambrechts, Diether; Van de Werf, Frans; Fox, Keith A.; El Mokhtari, Nour Eddine; Rubin, Diana; Schrezenmeir, Juergen; Schreiber, Stefan; Schaefer, Arne; Danesh, John; Blankenberg, Stefan; Roberts, Robert; McPherson, Ruth; Watkins, Hugh; Hall, Alistair S.; Overvad, Kim; Rimm, Eric; Boerwinkle, Eric; Tybjaerg-Hansen, Anne; Cupples, L. Adrienne; Reilly, Muredach P.; Melander, Olle; Mannucci, Pier M.; Ardissino, Diego; Siscovick, David; Elosua, Roberto; Stefansson, Kari; O'Donnell, Christopher J.; Salomaa, Veikko; Rader, Daniel J.; Peltonen, Leena; Schwartz, Stephen M.; Altshuler, David; Kathiresan, Sekar

    2012-01-01

    Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes

  3. Secondary prevention in coronary heart disease patients with low HDL : which options do we have?

    NARCIS (Netherlands)

    Liem, AH; Jukema, JW; van Veldhuisen, DJ

    2003-01-01

    Low levels of high-density lipoprotein cholesterol (HDL-C) are frequently encountered in patients with coronary artery disease (CAD), most often in combination with elevated triglycerides as part of a dysmetabolic syndrome. Although no large secondary prevention trials with statin therapy with speci

  4. Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels

    Directory of Open Access Journals (Sweden)

    Hinds David A

    2004-11-01

    Full Text Available Abstract Association studies are used to identify genetic determinants of complex human traits of medical interest. With the large number of validated single nucleotide polymorphisms (SNPs currently available, two limiting factors in association studies are genotyping capability and costs. Pooled DNA genotyping has been proposed as an efficient means of screening SNPs for allele frequency differences in case-control studies and for prioritising them for subsequent individual genotyping analysis. Here, we apply quantitative pooled genotyping followed by individual genotyping and replication to identify associations with human serum high-density lipoprotein (HDL cholesterol levels. The DNA from individuals with low and high HDL cholesterol levels was pooled separately, each pool was amplified by polymerase chain reaction in triplicate and each amplified product was separately hybridised to a high-density oligonucleotide array. Allele frequency differences between case and control groups with low and high HDL cholesterol levels were estimated for 7,283 SNPs distributed across 71 candidate gene regions spanning a total of 17.1 megabases. A novel method was developed to take advantage of independently derived haplotype map information to improve the pooled estimates of allele frequency differences. A subset of SNPs with the largest estimated allele frequency differences between low and high HDL cholesterol groups was chosen for individual genotyping in the study population, as well as in a separate replication population. Four SNPs in a single haplotype block within the cholesteryl ester transfer protein (CETP gene interval were significantly associated with HDL cholesterol levels in both populations. Our study is among the first to demonstrate the application of pooled genotyping followed by confirmation with individual genotyping to identify genetic determinants of a complex trait.

  5. An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration

    Directory of Open Access Journals (Sweden)

    Xun Chen, Charlotte Burton, Xuelei Song, Lesley Mcnamara, Annunziata Langella, Simona Cianetti, Ching H. Chang, Jun Wang

    2009-01-01

    Full Text Available Lecithin cholesterol acyltransferase (LCAT plays a key role in the reverse cholesterol transport (RCT process by converting cholesterol to cholesteryl ester to form mature HDL particles, which in turn deliver cholesterol back to the liver for excretion and catabolism. HDL levels in human plasma are negatively correlated with cardiovascular risk and HDL functions are believed to be more important in atheroprotection. This study investigates whether and how D-4F, an apolipoprotein A-I (apoA-I mimetic peptide, influences LCAT activity in the completion of the RCT process. We demonstrated that the apparent rate constant value of the LCAT enzyme reaction gives a measure of LCAT activity and determined the effects of free metals and a reducing agent on LCAT activity, showing an inhibition hierarchy of Zn2+>Mg2+>Ca2+ and no inhibition with β-mercaptoethanol up to 10 mM. We reconstituted nano-disc particles using apoA-I or D-4F with phospholipids. These particles elicited good activity in vitro in the stimulation of cholesterol efflux from macrophages through the ATP-binding cassette transporter A1 (ABCA1. With these particles we studied the LCAT activity and demonstrated that D-4F did not activate LCAT in vitro. Furthermore, we have done in vivo experiments with apoE-null mice and demonstrated that D-4F (20 mg/kg body weight, once daily subcutaneously increased LCAT activity and HDL level as well as apoA-I concentration at 72 hours post initial dosing. Finally, we have established a correlation between HDL concentration and LCAT activity in the D-4F treated mice.

  6. 30例心肌梗死病人血清LDL-C/HDL-C比值的分析%30 examples cardiac arrests patient blood serum LDL-C/HDL-C ratio analyzes

    Institute of Scientific and Technical Information of China (English)

    黄旭东

    2007-01-01

    目的:了解心肌梗死病人血清LDL-C/HDL-C比值与正常人群的差异.方法:对我院2006年1月~2007年6月收治的30例心梗病人的LDL-C/HDL-C检查结果进行回顾性调查,并与200例健康体检人群的结果进行对比.结果:心肌梗死病人的血清LDL-C/HDL-C比值显著升高.结论:LDL-C/HDL-C比值与动脉粥样硬化呈正相关,监测危险人群的LDL-C/HDL-C比值对预防动脉粥样硬化的发生有意义.

  7. 30例心肌梗死病人血清LDL-C/HDL-C比值的分析%30 examples cardiac arrests patient blood serum LDL-C/HDL-C ratio analysis

    Institute of Scientific and Technical Information of China (English)

    黄旭东

    2007-01-01

    目的:了解心肌梗死病人血清LDL-C/HDL-C比值与正常人群的差异.方法:对我院2006年1月~2007年6月收治的30例心梗病人的LDL-C/HDL-C检查结果进行回顾性调查,并与200例健康体检人群的结果进行对比.结果:心肌梗死病人的血清LDL-C/HDL-C比值显著升高结论:LDL-C/HDL-C比值与动脉粥样硬化呈正相关,监测危险人群的LDL-C/HDL-C比值对预防动脉粥样硬化的发生有意义.

  8. Caracterización morfométrica de la cuenca alta del río Sauce Grande.

    Directory of Open Access Journals (Sweden)

    Fernanda Julia Gaspari

    2013-01-01

    Full Text Available La cuenca alta del río Sauce Grande abastece el complejo hidráulico Embalse Paso de las Piedras, comportándose como servicio ambiental primordial para el consumo hídrico de Bahía Blanca. El análisis de las características morfométricas y funcionales de una cuenca hidrográfica a través de parámetros de forma, relieve y red de drenaje, es básico en la modelación hidrológica para determinar el movimiento y captación del agua de lluvia. Estos indicadores pueden apoyar una formulación de un Sistema de Pago por Servicios Ambientales, como estrategia básica de ordenamiento territorial y desarrollo local, centrado en la oferta de agua generada por la cuenca. El objetivo fue caracterizar morfométricamente la cuenca alta del río Sauce Grande. La metodología aplicada se basó en establecer y analizar los parámetros morfométricos mediante el uso de Sistemas de Información Geográfica y planillas de cálculo, a partir de un modelo digital del terreno e imágenes satelitales. Los resultados alcanzados definieron que la cuenca posee un área de 1502.6 km2. La longitud axial es de 41.6 km con un ancho promedio de 36.1 km. El Factor de forma (0.87 indica que posee forma alargada, siendo rectangular oblonga según el coeficiente de compacidad de Gravelius (2.8. La longitud del cauce principal es 58.34 km con pendiente media de 0.48 %. La densidad de drenaje es 0.27 km.km-2 y su coeficiente de sinuosidad 1.42. El tiempo de concentración es 11.8 hs. La curva hipsométrica adimensional corresponde a una cuenca con un avanzado grado de desarrollo. Todos estos parámetros facilitan la cuantificación del caudal líquido en la cuenca.

  9. Variación espacio-temporal de la densidad poblacional de erizo rojo Strongylocentrotus franciscanus (Echinodermata: Echinoidea: Strongylocentrotidae en Baja California Spatial and temporal variation of the population density of the red sea urchin Stronngylocenntrotus franciscanus (Echinodermata: Echinoidea: Strongylocentrotidae in Baja California

    Directory of Open Access Journals (Sweden)

    Julio S. Palleiro-Nayar

    2012-04-01

    Full Text Available Se estimó la densidad poblacional de erizo rojo, Strongylocentrotus franciscanus, en 10 localidades de la costa occidental de Baja California, México, donde se realiza la extracción comercial de este recurso pesquero. Se compararon las estimaciones realizadas en cuatro años muestreados: 2003, 2005, 2006 y 2008. Las variaciones observadas en las localidades analizadas indicaron diferencias espacio-temporales para la densidad de erizo rojo y diferencias en la estructura de tallas, las cuales estuvieron influenciadas principalmente por la intensidad de la pesca y al esporádico reclutamiento en cada sitio. Se encontraron dos localidades (Isla San Jerónimo y Arrecife Sacramento que destacaron por presentar una alta densidad de erizo rojo y una amplia estructura de tallas, predominando individuos de tallas entre 50 a 80 mm diámetro de caparazón, lo que podría indicar que la intensidad de pesca aparentemente tiene un menor efecto que en los otros sitios.Density estimations of red sea urchin Strongylocentrotus franciscanus were recorded in ten sites with commercial fisheries on the west coast of Baja California, Mexico. The estimations for the years 2003, 2005, 2006 and 2008 were compared. The variations observed in the study sites indicate important spatial and temporal differences in density and size structure, influenced by fishing intensity and sporadic recruitment in each site. We found two sites (San Jeronimo Island and Sacramento Reef with a high density and wide size structure; with a predominance of individuals of sizes from 50 to 80 mm with lest impact possible in fishing mortality for all sites.

  10. Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    Haan, W. de; Hoogt, C.C. van der; Westerterp, M.; Hoekstra, M.; Dallinga-Thie, G.M.; Princen, H.M.G.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Rensen, P.C.N.

    2008-01-01

    Objective: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity. Our aim was to determine whether the increase in HDL depends on CETP

  11. HDL cholesterol as a residual risk factor for vascular events and all cause mortality in patients with type 2 diabetes

    NARCIS (Netherlands)

    Sharif, Shahnam; Van Der Graaf, Yolanda; Nathoe, Hendrik M.; de Valk, Harold W.; Visseren, Frank L J; Westerink, Jan

    2016-01-01

    OBJECTIVE: To evaluate whether low HDL cholesterol (HDL-c) levels are a risk factor for cardiovascular disease and mortality in patients with type 2 diabetes and whether it remains a residual risk factor when attaining low LDL cholesterol (LDL-c) treatment goals or when LDL-c is treated with intensi

  12. Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia.

    Science.gov (United States)

    Gagnon, France; Jarvik, Gail P; Badzioch, Michael D; Motulsky, Arno G; Brunzell, John D; Wijsman, Ellen M

    2005-09-01

    Several genome scans in search of high-density lipoprotein (HDL) quantitative trait loci (QTLs) have been performed. However, to date the actual identification of genes implicated in the regulation of common forms of HDL abnormalities remains unsuccessful. This may be due, in part, to the oligogenic and multivariate nature of HDL regulation, and potentially, pleiotropy affecting HDL and other lipid-related traits. Using a Bayesian Markov Chain Monte Carlo (MCMC) approach, we recently provided evidence of linkage of HDL level variation to the APOA1-C3-A4-A5 gene complex, in familial combined hyperlipidemia pedigrees, with an estimated number of two to three large QTLs remaining to be identified. We also presented results consistent with pleiotropy affecting HDL and triglycerides at the APOA1-C3-A4-A5 gene complex. Here we use the same MCMC analytic strategy, which allows for oligogenic trait models, as well as simultaneous incorporation of covariates, in the context of multipoint analysis. We now present results from a genome scan in search for the additional HDL QTLs in these pedigrees. We provide evidence of linkage for additional HDL QTLs on chromosomes 3p14 and 13q32, with results on chromosome 3 further supported by maximum parametric and variance component LOD scores of 3.0 and 2.6, respectively. Weaker evidence of linkage was also obtained for 7q32, 12q12, 14q31-32 and 16q23-24.

  13. 30例心肌梗死病人血清LDL-C/HDL-C比值的分析

    Institute of Scientific and Technical Information of China (English)

    黄旭东

    2007-01-01

    目的:了解心肌梗死病人血清LDL-C/HDL-C比值与正常人群的差异。方法:对我院2006年1月~2007年6月收治的30例心梗病人的LDL-C/HDL-C检查结果进行回顾性调查,并与200例健康体检人群的结果进行对比。结果:心肌梗死病人的血清LDL-C/HDL-C比值显著升高结论:LDL-C/HDL-C比值与动脉粥样硬化呈正相关,监测危险人群的LDL-C/HDL-C比值对预防动脉粥样硬化的发生有意义。

  14. Genetic variation in the ABCA1 gene, HDL cholesterol, and risk of ischemic heart disease in the general population

    DEFF Research Database (Denmark)

    Frikke-Schmidt, Ruth

    2010-01-01

    Epidemiological studies consistently demonstrate a strong inverse association between low levels of high-density lipoprotein (HDL) cholesterol and increased risk of ischemic heart disease (IHD). This review focuses on whether both rare and common genetic variation in ABCA1 contributes to plasma...... levels of HDL cholesterol and to risk of IHD in the general population, and further seeks to understand whether low levels of HDL cholesterol per se are causally related to IHD. Studies of the ABCA1 gene demonstrate a general strategy for detecting functional genetic variants, and show that both common...... and rare ABCA1 variants contribute to levels of HDL cholesterol and risk of IHD in the general population. The association between ABCA1 variants and risk of IHD appears, however, to be independent of plasma levels of HDL cholesterol. With the recent identification of the largest number of individuals...

  15. Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels

    DEFF Research Database (Denmark)

    Haase, C L; Frikke-Schmidt, R; Nordestgaard, B G;

    2011-01-01

    OBJECTIVES: To determine whether mutations in APOA1 affect levels of high-density lipoprotein (HDL) cholesterol and to predict risk of ischaemic heart disease (IHD) and total mortality in the general population. BACKGROUND: Epidemiologically, risk of IHD is inversely related to HDL cholesterol...... levels. Mutations in apolipoprotein (apo) A-I, the major protein constituent of HDL, might be associated with low HDL cholesterol and predispose to IHD and early death. DESIGN: We resequenced APOA1 in 190 individuals and examined the effect of mutations on HDL cholesterol, risk of IHD, myocardial...... infarction (MI) and mortality in 10 440 individuals in the prospective Copenhagen City Heart Study followed for 31 years. Results were validated in an independent case-control study (n = 16 035). Additionally, we determined plasma ratios of mutant to wildtype (WT) apoA-I in human heterozygotes and functional...

  16. CRECIMIENTO Y PRODUCTIVIDAD DE CHAYA (Cnidoscolus chayamansa MCVAUGH, EUPHORBIACEAE) CON DENSIDAD DE PLANTACIÓN VARIABLE

    OpenAIRE

    Jesús Mao E. Aguilar Luna; Pedro A. Macario Mendoza; Esperanza Huerta Lwanga; Salvador Hernández Daumás; Ramiro de Alba Becerra; Eduardo García Villanueva

    2011-01-01

    Se evaluó el efecto que tiene la competenciainterespecífica en el crecimiento y la productividad de la chayacon densidad de plantación (DP) variable, en un suelocalcimórfico de tipo rendzina negra en Noh-Bec, Quintana Roo,México. La chaya se estableció a 1.50 x 3.00 m, utilizando estacassin hojas; se asoció con árboles jóvenes (menores de dosaños) de Cedrela odorata y Citrus latifolia en un diseño deplantación en círculo 'Nelder' de 3154 m2. Se establecieron ochoDP de 2602 a 3772 plantas.ha-1...

  17. Densidad estomática en hojas de Retrophyllum rospigliosii (Pilg.

    Directory of Open Access Journals (Sweden)

    Hoyos Gómez Saúl E.

    2005-12-01

    Full Text Available En R. rospigliosii la mitad de sus hojas sufren una torsión (resupinación, exponiendo su envés ontogénico a la luz y el haz a la sombra. El objetivo de este trabajo fue establecer si la resupinación tiene consecuencias a nivel ecofisiológico y que por esa razón las hojas resupinadas difieran de las no resupinadas en características morfológicas como la densidad estomática. Se encontró que, contrario a lo que ocurre en la mayoría de las especies, los haces ontogénicos de R. rospigliosii presentan una mayor densidad estomática que el envés y que tal polarización de los estomas no cambia por la torsión que sufran las hojas. Se propone que la condición de
    resupinación representa ventajas evolutivas para R. rospigliosii en el manejo del recurso hídrico, teniendo en cuenta que la transpiración disminuye en el haz ontogénico por su menor exposición a la radiación solar, el viento y las temperaturas extremas en las regiones altoandinas, donde se distribuye. Esto representa menor pérdida de agua en las hojas resupinadas. Resultaría interesante revisar otras posibles implicaciones fisiológicas y anatómicas de las hojas de esta
    especie en función de su resupinación.

  18. Discordance of Non-HDL and Directly Measured LDL Cholesterol: Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?

    Directory of Open Access Journals (Sweden)

    Lawrence Baruch

    2013-01-01

    Full Text Available Objective. To determine if non-HDL cholesterol (N-HDL and directly measured LDL cholesterol (D-LDL are clinically equivalent measurements. Patients and Methods. Eighty-one subjects recruited for 2 cholesterol treatment studies had at least 1 complete fasting lipid panel and D-LDL performed simultaneously; 64 had a second assessment after 4 to 6 weeks, resulting in 145 triads of C-LDL, D-LDL, and N-HDL. To directly compare N-HDL to D-LDL and C-LDL, we normalized the N-HDL by subtracting 30 from the N-HDL (N-HDLA. Results. There was significant correlation between N-HDLA, D-LDL, and C-LDL. Correlation was significantly greater between N-HDLA and C-LDL than between N-HDLA and D-LDL. A greater than 20 mg/dL difference between measures was observed more commonly between N-HDLA and D-LDL, 29%, than between C-LDL and N-HDLA, 11% (P<0.001, and C-LDL and D-LDL, 17% (P=0.028. Clinical discordance was most common, and concordance was least common between N-HDL and D-LDL. Conclusions. Our findings suggest that N-HDL cholesterol and D-LDL cholesterol are not clinically equivalent and frequently discordant. As N-HDL may be superior to even C-LDL for predicting events in statin-treated patients, utilizing N-HDL to guide therapy would appear to be preferable to D-LDL when C-LDL is inaccurate.

  19. EFECTO DEL RALEO SOBRE EL CRECIMIENTO Y LA DENSIDAD DE LA MADERA DE Pinus taeda IMPLANTADO EN MISIONES, ARGENTINA

    Directory of Open Access Journals (Sweden)

    Rodolfo Martiarena

    2014-01-01

    Full Text Available El mayor incremento en crecimiento de la plantación puede causar variación en las propiedades físicas de la madera, pudiendo disminuir la calidad de la misma para la industria. El objetivo del presente trabajo es evaluar el efecto de los tratamientos de raleo sobre el crecimiento y densidad de la madera de Pinus taeda implantado en Misiones, Argentina (25º 59’S - 54º24’O. La plantación se estableció en 1985 con densidad inicial de 1644 pl.ha -1 y se manejó con tres intensidades de raleo (0, 33 y 66 % del área basal del testigo sin ralear, bajo un diseño de bloques completos al azar (3 bloques. A los 20 años se efectuó tala rasa, cuyas densidades eran 711 (0 %, 364 (33 % y 122 (66 % plantas por hectárea, momento en el cual se seleccionaron 45 árboles para determinar la densidad básica de la madera. La misma se determinó a través de la realización de 2.700 probetas. El crecimiento de la plantación fue afectado por la intensidad de raleo, registrando diámetros promedio de 28,7, 34,8 y 45,9 cm, respectivamente, en los tratamientos 0, 33 y 66 % de raleo. El volumen de la plantación, al momento del apeo, fue superior en el tratamiento sin raleo, no obstante el tratamiento 66 % de raleo generó mayor cantidad de madera de grandes dimensiones. La densidad básica como promedio simple y ponderado por volumen no presentó diferencias significativas entre tratamientos. Los valores de densidad ponderada fueron de 0,406, 0,418 y 0,420 g.cm -3 para los tratamientos 0, 33 y 66 % de raleo, respectivamente, mientras que el análisis de correlación entre diámetro y densidad no fue significativo. El estudio mostró que la intensidad de raleo puede ser manejada para maximizar la producción, manteniendo idéntica la calidad de la madera para la industria.

  20. TransForm: TransAlta 2000 annual report

    International Nuclear Information System (INIS)

    Financial information from TransAlta Corp. was presented along with a review of their operations throughout 2000 and a summary of the how the electric utility is doing in terms of power generation, independent power producers, transmission and energy marketing. The utility has changed from a regulated vertically integrated utility into one of Canada's largest non-regulated electric power generators. The utility sold its retail businesses in Alberta and New Zealand and now focuses on coal and hydro generation, gas generation, high-voltage transmission and energy marketing. The newly constructed Centralia, Washington generation facility was brought on line with 1,340 MW in May 2000, on time and on budget. This was the platform to diversify their generation into the United States. The utility reported a solid financial year with $177.9 million in earnings from continuing operations, an 83 per cent increase from 1999, driven mostly by the results of Centralia and power marketing and trading businesses. A financial loss was suffered when the Wabamum power plant in Alberta was shut down for several months to repair a boiler. The utility made excellent progress toward their goal of 15,000 megawatts by 2005 by starting with the construction of what will be one of Canada's largest cogeneration facilities at Sarnia, Ontario. TransAlta also commissioned a 360 MW cogeneration facility at Poplar Creek at Suncor's Fort McMurray oil sand facility. TransAlta also has an excellent track record in developing power generation projects internationally. refs., tabs., figs

  1. Alta disponibilidad para componentes de fabricación

    OpenAIRE

    Maciá Pérez, Francisco; Marcos Jorquera, Diego; Gilart Iglesias, Virgilio

    2006-01-01

    A medida que las tecnologías de la información van calando en el tejido productivo industrial, tanto más compleja se vuelve su organización. Es imprescindible introducir sistemas de gestión proactivos y autogestionados que aseguren su funcionamiento continuado y, en consecuencia, la continuidad en el negocio. En este artículo se propone un sistema de regeneración de los elementos de producción industrial que traslada el concepto de alta disponibilidad a los niveles de fabricación de la organi...

  2. Perfil docente para alumnos/as con altas capacidades

    OpenAIRE

    María Leonor Conejeros-Solar; María Paz Gómez-Arizaga; Elizabeth Donoso-Osorio

    2013-01-01

    El presente artículo tiene por objeto determinar un perfil de competencias docentes construido desde la percepción de estudiantes con altas capacidades pertenecientes a un programa universitario para talentos académicos. Se utiliza una metodología cualitativa con una estrategia documental de carácter retrospectivo. Los resultados indican que los estudiantes realizan una evaluación profunda sobre la docencia, incluyendo elementos pedagógicos como flexibilidad, ritmo e integración teoría-prácti...

  3. Vulnerabilidad en la cuenca alta del rio Lerma

    OpenAIRE

    Cedeño Valdiviezo, Alberto; Torres Lima, Pablo

    2013-01-01

    La subcuenca Alta del Río Lerma en el Estado de México, importante abastecedor de agua para la Ciudad de México, ha estado expuesta a una fuerte contaminación en los últimos años, misma que ha tenido como consecuencia el Cambio Climático y los consecuentes problemas de salud pública que se están manifestando de diferentes maneras. No obstante, el Estado Mexicano insiste en seguir apoyando a empresas trasnacionales asociadas al cultivo de transgénicos, producción de plaguicidas, pesticidas y P...

  4. Matrices estructuradas y alta precisión relativa

    OpenAIRE

    Barreras Peral, Álvaro; Peña Ferrández, Juan Manuel

    2014-01-01

    Esta memoria se enmarca, dentro del Algebra Lineal Numérica, en el campo de estudio de métodos numéricos adaptados a clases de matrices con estructura especial, que es un campo que muestra una intensa y creciente actividad investigadora. Concretamente, considerará clases de matrices para las que se encontrarán métodos numéricos cuyo cálculo se podrá llevar a cabo con alta precisión relativa. Conseguir cálculos precisos es una propiedad muy deseable para cualquier método numérico. El ideal es ...

  5. Proyecto de Historia como respuesta educativa a las altas capacidades

    OpenAIRE

    Miguel Yoldi, Yohanna

    2014-01-01

    Este trabajo presenta una propuesta de intervención en el aula que responde a las necesidades educativas del alumnado con altas capacidades, desde una escuela inclusiva. Para realizarlo, nos hemos basado en dos autores: Roger J. Sternberg y Joseph S. Renzulli, que no sólo definen las características y necesidades educativas de este colectivo, sino que también proponen posibles respuestas que respondan a su forma de aprender. Desde el área de Ciencias Sociales, apostamos por el aprendizaje bas...

  6. Todos iguales, todos diferentes. Altas capacidades en el aula.

    OpenAIRE

    Soloaga Martín, Beatriz

    2012-01-01

    El presente trabajo se centra en el alumnado de altas capacidades y las posibilidades de atención en el marco del modelo de escuela inclusiva. Se comienza explicando las características de estos alumnos, los estereotipos que existen sobre ellos y las disincronías que es frecuente encontrar en su desarrollo. Se sigue la clasificación de varios autores para distinguir entre superdotación y talento viendo las diferencias significativas que existen entre ellos. De forma breve se ha...

  7. Fitomorfologia e produção de cultivares de trigo duplo propósito em diferentes manejos de corte e densidades de semeadura Phytomorphology and production of dual purpose wheat with different cutting regimes and seeding density

    Directory of Open Access Journals (Sweden)

    Thomas Newton Martin

    2010-08-01

    Full Text Available A diversificação de cultivares e finalidades da cultura do trigo podem alterar as indicações de manejo no sistema de integração lavoura-pecuária. Dessa forma, este trabalho tem como objetivo verificar o desempenho das cultivares de trigo duplo propósito em diferentes densidades de semeadura, com e sem corte. As cultivares de trigo utilizados foram: 'BRS Figueira', 'BRS Guatambu', 'BRS Tarumã' e 'BRS Umbu', e as densidades de semeadura utilizadas foram de 50, 200, 350, 500 e 650 sementes por metro quadrado. As variáveis fitomorfológicas e de produção possuem um desempenho diferenciado conforme a cultivar, o manejo e a densidade de semeadura. A cultivar 'Figueira' possui o maior potencial produtivo dentro dos limites de densidades estudados quanto à produção de massa seca, em relação aos demais cultivares. A produção de grãos teve interação significativa entre as cultivares e o manejo (com e sem corte. As cultivares com maiores produções de grãos foram, respectivamente, 'Figueira', 'Umbu', 'Tarumã' e 'Guatambu' no manejo sem corte, já no sistema com corte a cultivar 'Tarumã' foi a que obteve o maior rendimento de grãos, diferenciando-se das demais. A maioria das correlações altas e significativas ocorreu nos manejos com e sem corte. O corte diminuiu todos os valores dos componentes de rendimento, bem como a produção de grãos de todos as cultivares.The diversification of cultivars and purposes of wheat crop may alter the information management system of crop-livestock integration. Therefore, this research has the objective to verify the performance of dual purpose wheat with different cutting regimes and seeding density. The whet cultivate used were: 'BRS Figueira', 'BRS Guatambu', 'BRS Tarumã' and 'BRS Umbu'. The seeding density was of 50, 200, 350, 500 and 650 seeds for square meter. The phitomorfological and production variables have a different performance depending on as cultivar, management and seeding

  8. The usefulness of information on HDL-cholesterol: potential pitfalls of conventional assumptions

    OpenAIRE

    Furberg Curt D

    2001-01-01

    Abstract Treatment decisions related to disease prevention are often based on two conventional and related assumptions. First, an intervention-induced change in a surrogate marker (such as high-density lipoprotein [HDL]-cholesterol) in the desired direction translates into health benefits (such as reduction in coronary events). Second, it is unimportant which interventions are used to alter surrogate markers, since an intervention benefit is independent of the means by which it is achieved. T...

  9. Oxidised LDL, HDL cholesterol, LDL cholesterol levels in patients of coronary artery disease

    OpenAIRE

    Ghosh, Joya; T K Mishra; Rao, Y. N.; Aggarwal, S. K.

    2006-01-01

    Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol, high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and sex matched normal healthy individuals were taken as controls and 60 patients of CAD were taken. Cholesterol was measured by enzymatic method,...

  10. ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression

    DEFF Research Database (Denmark)

    Burillo, Elena; Lindholt, Jes S.; Molina-Sánchez, Pedro;

    2015-01-01

    proteomic analysis of plasma proteins was performed in AAA patients at different stages of evolution [small AAA (aortic size=3-5 cm) vs large AAA] using iTRAQ labelling, high-throughput nano-LC-MS/MS and a novel multi-layered statistical model. Among the proteins identified, ApoA-I was decreased in patients...... with large AAA compared to those with small AAA. These results were validated by ELISA on plasma samples from small (n=90) and large AAA (n=26) patients (150± 3 vs 133± 5 mg/dl, respectively, pA-I levels strongly correlated with HDL-Cholesterol (HDL-C) concentration (r=0.9, p....89± 2.99 vs 1.59± 5.74 mmol/l, pA-I mimetic peptide compared with saline-injected controls. In conclusion, ApoA-I/HDL-C systemic levels are negatively associated with AAA evolution. Therapies targeting...

  11. Improvement of HDL- and LDL-cholesterol levels in diabetic subjects by feeding bread containing chitosan.

    Science.gov (United States)

    Ausar, S F; Morcillo, M; León, A E; Ribotta, P D; Masih, R; Vilaro Mainero, M; Amigone, J L; Rubin, G; Lescano, C; Castagna, L F; Beltramo, D M; Diaz, G; Bianco, I D

    2003-01-01

    In this work we evaluated the efficacy and safety of a bread formulation containing chitosan in dyslipidemic type 2 diabetic subjects. For this purpose a total of 18 patients were allowed to incorporate to their habitual diets 120 g/day of bread containing 2% (wt/wt) chitosan (chitosan group, n= 9) or standard bread (control group, n= 9). Before the study and after 12 weeks on the modified diet, the following parameters were evaluated: body weight, plasma cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglyceride, and hemoglobin A(1c) (HbA(1c)). Compared with the control group, the patients receiving chitosan-containing bread decreased their mean levels of LDL-cholesterol and significantly increased their mean levels of HDL-cholesterol at the end of the study. There were no significant differences in the body weight, serum triglyceride, and HbA(1c). These results suggest that chitosan incorporated into bread formulations could improve the lipoprotein balance similar to typical biliary salts trappers, increasing the HDL- and lowering the LDL-cholesterol, without changing the triglyceride levels. These results warrant further studies over a longer period of time to evaluate if a persistent improvement in levels of lipoproteins can be attained with this strategy.

  12. A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fat to modulate serum HDL-cholesterol concentrations.

    Science.gov (United States)

    Baik, Inkyung; Lee, Seungku; Kim, Seong Hwan; Shin, Chol

    2013-10-01

    There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common LPL polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40-69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genome-wide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (S447×) mutation (D' = 0.99) of LPL. We found that carrying the T allele reflecting the LPL ×447 allele was positively associated with follow-up measurement of HDL-C concentrations (P HDL-C concentration and potential risk factors, we observed interactive effects of the polymorphism and consumption of alcohol (P-interaction unsaturated fat (P-interaction HDL-C concentrations. We also observed interactive effects of the polymorphism and body mass index (P-interaction unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the LPL ×447 allele need to control body weight to prevent hypertriglyceridemia.

  13. Technology for Salt Production in the Mixteca Alta

    Directory of Open Access Journals (Sweden)

    Ricardo Antonio León Hernández

    2015-01-01

    Full Text Available Salt production in the Mixteca Alta is a traditional means of production from prehispanic period, which, despite the economic transformation processes in the colonial period, remained significant features of the traditional process, based on the documented similar models from other productive regions in Mexico. The salt in the novohispanic period was considered a major consumption economic asset due to its use in production processes for the production of new economic products that supported the economy of preindustrial societies (Terán, 2011, p. 71; Williams, 2008. Technology refers to the knowledges for solving human needs arising lifestyle of the cultural groups that develop them. The resources of the natural environment underpin the means of labor that man requires to perform its activities, including economic. The means of production and production processes are technological developments, which involve elements of tangible and intangible order. The study of work processes for salt extraction, are significantly related to the processes of technological evolution that man has developed for the use of natural resources. The economic activities of the primary sector are examples of how humans culturally and economically were inserted in the natural environment (Malpica, 2008, p. 59. This analysis presents a historiographical approach to the study of the processes and the technology required for the extraction of salt in the Mixteca Alta.

  14. Low HDL cholesterol as a cardiovascular risk factor in rural, urban, and rural-urban migrants: PERU MIGRANT cohort study

    Science.gov (United States)

    Lazo-Porras, María; Bernabe-Ortiz, Antonio; Málaga, Germán; Gilman, Robert H.; Acuña-Villaorduña, Ana; Cardenas-Montero, Deborah; Smeeth, Liam; Miranda, J. Jaime

    2016-01-01

    Introduction Whilst the relationship between lipids and cardiovascular mortality has been well studied and appears to be controversial, very little has been explored in the context of rural-to-urban migration in low-resource settings. Objective Determine the profile and related factors for HDL-c patterns (isolated and non-isolated low HDL-c) in three population-based groups according to their migration status, and determine the effect of HDL-c patterns on the rates of cardiovascular outcomes (i.e. non-fatal stroke and non-fatal myocardial infarction) and mortality. Methods Cross-sectional and 5-year longitudinal data from the PERU MIGRANT study, designed to assess the effect of migration on cardiovascular risk profiles and mortality in Peru. Two different analyses were performed: first, we estimated prevalence and associated factors with isolated and non-isolated low HDL-c at baseline. Second, using longitudinal information, relative risk ratios (RRR) of composite outcomes of mortality, non-fatal stroke and non-fatal myocardial infarction were calculated according to HDL-c levels at baseline. Results Data from 988 participants, rural (n = 201), rural-to-urban migrants (n = 589), and urban (n = 199) groups, was analysed. Low HDL-c was present in 56.5% (95%CI: 53.4%–59.6%) without differences by study groups. Isolated low HDL-c was found in 36.5% (95%CI: 33.5–39.5%), with differences between study groups. In multivariable analysis, urban group (vs. rural), female gender, overweight and obesity were independently associated with isolated low HDL-c. Only female gender, overweight and obesity were associated with non-isolated low HDL-c. Longitudinal analyses showed that non-isolated low HDL-c increased the risk of negative cardiovascular outcomes (RRR = 3.46; 95%CI: 1.23–9.74). Conclusions Isolated low HDL-c was the most common dyslipidaemia in the study population and was more frequent in rural subjects. Non-isolated low HDL-c increased three-to fourfold

  15. Avaliação da densidade óssea para instalação de mini-implantes Bone density assessment for mini-implants positioning

    OpenAIRE

    Marlon Sampaio Borges; José Nelson Mucha

    2010-01-01

    INTRODUÇÃO: além da espessura da cortical óssea e da largura dos espaços inter-radiculares, a densidade óssea é fator primordial para a eficiência dos mini-implantes usados como recurso de ancoragem. OBJETIVO: nesse estudo, pretendeu-se avaliar a densidade óssea alveolar e basal maxilar e mandibular, em unidades Hounsfield (HU). MÉTODOS: em onze arquivos de imagens tomográficas computadorizadas Cone-Beam, de indivíduos adultos, foram obtidas 660 medidas das densidades ósseas alveolar (cortica...

  16. Densidades de siembra de dos variedades comerciales de crisantemo, Chrysantemum morifolium Ramat en Piendamo (Cauca

    Directory of Open Access Journals (Sweden)

    Posada D. Adolfo

    1986-09-01

    Full Text Available The behavior and agricultural characteristics of two kinds of Chrysanthemum (White Marble and Yellow Polaris were evaluated in terms of yield and quality of the product. Two different kinds of planting systems were applied (single stem and pinched stem. The experimental design in randomized whole blocks for each variety and system including four density treatments (80, 90, 110 and 115 sterns per 1.05 m2 was repeated six times. The experimental unit was of 2.10 m2; 1.26 m2 were harvested. A strong discrepancy between the quantity and quality of the product was observed. The highest yields were obtained with densities of 110 and 115 stems per 1.05 m2. However, the experimental units dis not always met both requirements of a diameter greater than seven cm and three or more marketable flowers per stem. If maximizing production of acceptable bunches is taken as a decision variable, a density of 90 sterns per 1.05 m2 with a 3/3/2/2/2/3/3 arrangement with pinched stern for Yellow Polar is seems a better alternative. As for White Marble, it would be better to have 80 stems per 1.05 m2 with a 3/2/2/2/2/2/3 arrangement in the single stem, but the probability of acceptance is only 0.666. In addition, White Marble showed more susceptibility to dwarfism.Se evaluó el comportamiento y características agronómicas asociadas con el rendimiento y la calidad del producto en las variedades White Marble y Yellow Polaris, en los sistemas de tallo único y tallo despuntado. El diseño experimental de bloques completos al azar para cada variedad y sistema incluía cuatro tratamientos de densidad (80, 90, 110 Y 115 tallos por 1.05 m2, con seis repeticiones. La unidad experimental fue de 2.10 m2, cosechando 1. 26m2(1.05 x 1.20. Se observó marcado antagonismo entre la cantidad y la calidad del producto comercial. Los mayores rendimientos se obtuvieron con densidades de 110 y 115 tallos por 1.05 m2, pero no siempre la producción cumplía con los requisitos de di

  17. Alta parasitemia pelo Trypanosoma cruzi em paciente com lupus eritematoso sistêmico

    OpenAIRE

    Santos-Neto Leopoldo Luiz dos; Polcheira Máira F.; Castro Cleudson; Lima Rodrigo Aires Corrêa; Simaan César Kozak; Corrêa-Lima Francisco Aires

    2003-01-01

    É descrito um caso de doença de Chagas com alta parasitemia pelo Trypanosoma cruzi em paciente com lupus eritematoso sistêmico. O xenodiagnóstico foi útil na identificação da parasitemia e o benznidazol foi capaz de reduzir a alta e incomum parasitemia. Em indivíduos com doenças auto-imunes e immunossuprimidos, o benznidazol pode ser uma alternativa no controle da alta parasitemia por Trypanosoma cruzi.

  18. Use of solaria to predict weed density and floristic composition in no-till cropping systems Uso de solaria na predição da densidade de ervas daninhas e da composição florística no sistema de semeadura direta

    Directory of Open Access Journals (Sweden)

    Pablo Antonio Calviño

    2006-03-01

    a densidade de espécies com densidades altas e baixas de indivíduos em áreas de 10 ha com o uso apenas de cinco solaria. Espécies com baixas densidades tornam o método particularmente útil para ajudar a decidir o uso ou não de herbicidas para evitar a contaminação da terra.

  19. Plasma pre beta-HDL formation is decreased by atorvastatin treatment in type 2 diabetes mellitus : Role of phospholipid transfer protein

    NARCIS (Netherlands)

    Dallinga-Thie, G. M.; van Tol, A.; Dullaart, R. P. F.

    2009-01-01

    Atorvastatin lowers plasma phospholipid transfer protein (PLTP) activity, which stimulates pre-beta-HDL, generation in vitro. We determined the effect of atorvastatin on pre-beta-HDL formation and its relation with PLTP activity in type 2 diabetes. Methods: Plasma pre-beta-HDL formation as well as p

  20. Resultados da conjuntivodacriocistorrinostomia com implante de prótese lacrimal de polietileno de baixa densidade

    Directory of Open Access Journals (Sweden)

    Bison Simone

    2002-01-01

    Full Text Available Objetivos: Estabelecer quais são as complicações pós-operatórias da conjuntivodacriocistorrinostomia (CDCR com implante de prótese lacrimal de polietileno de baixa densidade e relacionar a etiologia da obstrução e o aparecimento destas complicações e, conseqüentemente, o sucesso pós-operatório. Métodos: Foram analisadas 35 vias lacrimais submetidas a conjuntivodacriocistorrinostomia com implante de prótese lacrimal de polietileno. Com a finalidade de estudar as possíveis relações entre as variáveis encontradas (etiologia x complicações e etiologia x sucesso realizou-se o teste exato de Fisher. Resultados: As etiologias de obstrução mais freqüentes foram a dacriocistite crônica e pós-dacriocistorrinostomia que, em conjunto, foram responsáveis por 53,9% dos casos. Os traumatismos ocasionaram 16,3% das obstruções. A taxa de complicações encontrada foi 74,3%. A conjuntivodacriocistorrinostomia apresentou sucesso em uma única intervenção cirúrgica em 9 vias lacrimais (25,7%. Após duas ou mais intervenções cirúrgicas, 17 próteses lacrimais tornaram-se pérvias e bem localizadas (48,6%. O insucesso ocorreu em 9 vias lacrimais (25,7%. Não houve relação estatisticamente significante entre etiologia e ocorrência de complicações nem entre etiologia e sucesso pós-operatório. Conclusões: As complicações encontradas são similares às descritas na literatura e não tiveram relação com a etiologia da obstrução canalicular. O mesmo pode ser considerado no que se refere ao sucesso da conjuntivodacriocistorrinostomia. As vantagens da prótese lacrimal de polietileno de baixa densidade são a grande disponibilidade, a fácil confecção no per-operatório de acordo com o comprimento e o diâmetro do colarete desejados e pode ser substituída pela prótese lacrimal de vidro de borosilicato assim que o edema regrida.

  1. Caracterización de las densidades en autómatas celulares binarios unidimensionales con retardo

    Directory of Open Access Journals (Sweden)

    José Manuel Gómez Soto

    2010-01-01

    La caracterización de la densidad en estos autómatas celulares es importante ya que las transmisiones de señales con retardo están en muchos sistemas de la naturaleza. Entre ellos se encuentra la regularización del gen, las neuronas cerebrales y las señales en cascada en organismos multicelulares. Determinar entonces el comportamiento de la densidad en estos modelos nos dirá más acerca del fenómeno que se simula con ellos y acerca del modelo mismo, obtendremos más información sobre que tan robusto es el espacio temporal, cómo cambia su dinámica y cómo se afecta su capacidad de procesamiento de información.

  2. DENSIDAD Y DISTRIBUCIÓN SOBRE CSMA/CA EN REDES IEEE 802.11G EN MODO AD HOC

    OpenAIRE

    José Domínguez

    2009-01-01

    El propósito principal de la presente investigación, fue determinar la influencia de la densidad y distribución de hosts sobre el control de acceso al medio en redes IEEE 802.11g, tomando como variables fundamentales la densidad y distribución de los mismos y el protocolo CSMA/CA para el acceso al medio de transmisión. La investigación fue de tipo explicativa, con un diseño experimental puro. La misma se basó en los postulados teóricos de Bates (2003), Comer (2000), León García (2001), Sta...

  3. Relações hídricas em povoamento de eucalipto com diferentes densidades populacionais

    Directory of Open Access Journals (Sweden)

    F. P. Leite

    1999-03-01

    Full Text Available Em experimento realizado na região de Santa Bárbara (MG, no período de agosto de 1994 a fevereiro de 1995, avaliaram-se a precipitação pluviométrica interna, a evapotranspiração da cultura (ETc e o regime hídrico do solo sob povoamento de Eucalyptus grandis (dos 32 aos 38 meses de idade com densidades populacionais variando de 500 a 5.000 plantas ha-1. A umidade volumétrica do solo, em uma seção de controle de 0 a 285 cm de profundidade, foi determinada quinzenalmente, por meio de moderação de nêutrons. A interceptação de água pelas copas aumentou linearmente com o aumento da população de plantas, enquanto a ETc não foi significativamente influenciada. A umidade do solo tendeu a aumentar com a redução da população de plantas. A umidade do solo em todas as épocas monitoradas nunca apresentou valores inferiores àquele correspondente à água retida à tensão de 1,5 MPa.

  4. CRECIMIENTO Y PRODUCTIVIDAD DE CHAYA (Cnidoscolus chayamansa MCVAUGH, EUPHORBIACEAE CON DENSIDAD DE PLANTACIÓN VARIABLE

    Directory of Open Access Journals (Sweden)

    Jesús Mao E. Aguilar Luna

    2011-01-01

    Full Text Available Se evaluó el efecto que tiene la competenciainterespecífica en el crecimiento y la productividad de la chayacon densidad de plantación (DP variable, en un suelocalcimórfico de tipo rendzina negra en Noh-Bec, Quintana Roo,México. La chaya se estableció a 1.50 x 3.00 m, utilizando estacassin hojas; se asoció con árboles jóvenes (menores de dosaños de Cedrela odorata y Citrus latifolia en un diseño deplantación en círculo 'Nelder' de 3154 m2. Se establecieron ochoDP de 2602 a 3772 plantas.ha-1 con 10 repeticiones. Lasvariables de respuesta fueron: capacidad de enraizamiento,tasa de crecimiento, índice de vigor, índice de área foliar yproducción de biomasa. El mayor enraizamiento de estacas dechaya se obtuvo de 2889 a 3772 plantas.ha-1; sin embargo, elmejor crecimiento y productividad se obtuvo de 2706 a2889 plantas.ha-1.

  5. Unacylated Ghrelin is associated with the isolated low HDL-cholesterol obese phenotype independently of insulin resistance and CRP level

    Directory of Open Access Journals (Sweden)

    Nogueira Juan-Patricio

    2012-03-01

    Full Text Available Abstract Background Low plasma high-density lipoprotein-cholesterol (HDL-c level is commonly present in obesity and represents an independent cardiovascular risk factor. However, obese patients are a very heterogeneous population and the factors and mechanisms that contribute to low HDL-c remain unclear. The aim of this study was to investigate the association between plasma HDL-c levels and plasma hormonal profiles (insulin, adiponectin, resistin, leptin and ghrelin in subsets of class II and III obese patients. Methods Fasting plasma levels of glucose, total cholesterol, LDL-c, HDL-c, triglycerides, free fatty acids, apoproteins A-I, B-100, B-48, C-II, C-III, insulin, hs-CRP, adipocytokines (adiponectin, resistin, leptin, unacylated ghrelin, body composition (DXA and resting energy expenditure were measured in three subsets of obese patients: 17 metabolically abnormal obese (MAO with metabolic syndrome and the typical metabolic dyslipidaemia, 21 metabolically healthy obese (MHO without metabolic syndrome and with a normal lipid profile, and 21 isolated low HDL-c obese patients (LHO without metabolic syndrome, compared to 21 healthy lean control subjects. Results Insulin resistance (HOMA-IR increased gradually from MHO to LHO and from LHO to MAO patients (p p = 0.032. Conclusions These results suggest that, in class II and III obese patients with an isolated low HDL-c phenotype, unacylated ghrelin is positively associated with HDL-c level independently of insulin resistance and CRP levels, and may contribute to the highly prevalent low HDL-c level seen in obesity.

  6. EVALUACIÓN DE DENSIDADES DE PLANTACIÓN EN EL CULTIVO DE LA JAMAICA (Hibiscus sabdariffa L.

    Directory of Open Access Journals (Sweden)

    Z. Terán

    2004-01-01

    Full Text Available La investigación se llevó a cabo en el Instituto Nacional de Ciencias Agrícolas (INCA, en el verano del 2001, con el objetivo de comparar seis distancias de plantación en el cultivo de la Jamaica ( Hibiscus sabdariffa L. y su influencia en los rendimientos y sus componentes por superficie para definir la densidad óptima. Las distancias empleadas fueron: 1.20x1.00m; 1.20x0.90m; 1.00x1.00m; 1.00x0.90m; 0.90x0.90m y 0.90x0.80m; a esos marcos de plantación correspondieron las siguientes densidades: 8 333, 9 260, 10 000, 11 111, 12 345 y 13 888 plantas.ha -1 . Se utilizó un diseño de bloques al azar con cuatro repeticiones. Se evaluaron el peso de frutos más el cáliz fresco y seco por separado. Los datos se procesaron mediante un Análisis de Varianza de Clasificación Simple, encontrándose di- ferencias significativas entre los tratamientos. Los resultados mostraron que los rendimientos se comportaron en correspon- dencia con las densidades de plantación, obteniéndose 7.53 t.ha -1 de cálices frescos en la mayor densidad y 4.5 t.ha -1 en la menor.

  7. Densidad poblacional del venado cola blanca (Odocoileus virginianus en sabana inindable de Paz De Ariporo (Casanare, Orinoquia colombiana

    Directory of Open Access Journals (Sweden)

    Montenegro Olga Lucía

    2006-12-01

    Full Text Available Esta investigación buscó estimar y analizar las diferencias en la densidad poblacional del venado cola blanca
    (Odocoileus virginianus en dos hatos de la Orinoquia colombiana, con miras a aportar elementos para su manejo
    sostenible en la región. Para la estimación de densidad se realizaron conteos de individuos y grupos en transectos
    lineales de ancho variable acumulando 54,3 km y 48,65 km en los hatos Taparas y Miramar respectivamente.
    Estos recorridos se realizaron entre junio y julio de 2005, que corresponde a la época de lluvias. La densidad tanto
    de individuos como de grupos de venados fue mayor en el hato Taparas (0,44 venados/ha y 0,148 grupos/ha
    respectivamente que en el hato Miramar (0,11 venados/ha y 0,086 grupos/ha respectivamente. El número de hembras observadas fue mayor que el número de machos tanto en el hato Taparas (c2=165,8, p <0,05 como en el hato Miramar (c2=18, p <0,05. En los dos hatos la distribución de edades se caracterizó por una mayor proporción de adultos seguido por juveniles y crías. En el hato Taparas el tamaño promedio de grupo fue de 3,01, mientras en el hato Miramar éste fue de 1,55 individuos. Se discuten las diferencias en densidad en los dos hatos a la luz de presiones de cacería, variaciones en el hábitat e interacciones con el ganado vacuno de la zona.

  8. Comparison of effects of diet versus exercise weight loss regimens on LDL and HDL particle size in obese adults

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    Klempel Monica C

    2011-07-01

    Full Text Available Abstract Background Obesity is associated with an atherogenic lipid profile characterized by a predominance of small LDL and HDL particles. Weight loss, by dietary restriction or exercise, increases LDL particle size. Whether these interventions can augment HDL size in conjunction with LDL size remains unknown. Objective This study compared the effects of alternate day fasting (ADF, calorie restriction (CR, and endurance exercise on LDL and HDL particle size in overweight and obese subjects. Methods In a 12-week parallel-arm trial, adult subjects (n = 60 were randomized to 1 of 4 groups: 1 ADF (75% energy restriction for 24-h alternated with ad libitum feeding for 24-h, 2 CR (25% energy restriction every day, 3 exercise (moderate intensity training 3 x/week, or 4 control. Results Body weight was reduced (P P P P = 0.01 by ADF and CR. The proportion of small LDL particles decreased (P = 0.04 with ADF only, and the proportion of large HDL particles increased (P = 0.03 with exercise only. Conclusion These results indicate that dietary restriction increases LDL particle size, while endurance training augments HDL particle size, with minimal weight loss. None of these interventions concomitantly increased both LDL and HDL particle size, however.

  9. Influência da densidade do solo no desenvolvimento inicial do pinhão-manso cultivado em Latossolo Vermelho eutroférrico

    Directory of Open Access Journals (Sweden)

    Tatiane Ohland

    2014-10-01

    Full Text Available Este trabalho teve por objetivo avaliar a influência da densidade do solo no desenvolvimento inicial da cultura do pinhão-manso. O experimento foi realizado em vasos de 10,6 dm³, em casa de vegetação. O solo utilizado foi o Latossolo Vermelho eutroférrico de textura argilosa, coletado em Marechal Cândido Rondon - PR. O delineamento experimental utilizado foi o de blocos casualizados, composto por cinco níveis de densidade do solo (1,08; 1,22; 1,36; 1,50 e 1,64 kg dm-3, com quatro repetições. Após 120 dias da emergência das plantas, foram efetuadas as avaliações biométricas e as relativas ao do tecido vegetal. Houve redução de 25% da altura das plantas, na densidade de 1,64 kg dm-3, quando,comparada com a da densidade de 1,08 kg dm-3. Para o comprimento radicular, a redução foi de aproximadamente 24 , 35 , 54 e 66 % para as densidades de 1,22; 1,36; 1,50 e 1,64 kg dm-3 respectivamente, quando comparadas com o da densidade de 1,08 kg dm-3. A limitação do desenvolvimento da parte aérea ocorreu a partir da densidade estimada de 1,26 kg dm-3, com redução do número de folhas, da área foliar e da produção de matéria seca da parte aérea. O desenvolvimento do sistema radicular e o conteúdo de P e K nas plantas de pinhão-manso reduziram-se linearmente com o aumento da densidade do solo.

  10. Medida de densidades con el picnómetro y de tensión superficial con el estalagmómetro

    OpenAIRE

    Espinosa Tomás, Julián; Pérez Rodríguez, Jorge; Miret Marí, Juan José; Caballero Caballero, María Teresa

    2010-01-01

    Guión de la práctica de Física de primero de grado de Óptica y Optometría "MEDIDA DE DENSIDADES CON EL PICNÓMETRO Y DE TENSIÓN SUPERFICIAL CON EL ESTALAGMÓMETRO" Objetivos: Medir densidades de sólidos y líquidos. Medir la tensión superficial de un líquido problema con el estalagmómetro.

  11. Performance of juvenile turbot (Scophthalmus maximus fed varying dietary L-carnitine levels at different stocking densities Desempenho de juvenis de pregado (Scophthalmus maximus em função da densidade de estocagem e de níveis dietéticos de L-carnitina

    Directory of Open Access Journals (Sweden)

    José Fernando Magalhães Gonçalves

    2010-04-01

    (75,6 ± 2,8 g alimentados durante 75 dias a dois níveis dietéticos de L-carnitina (40 ou 240 mg kg¹. Após esse período, determinou-se a excreção de amônia pós-prandial durante 24 horas. Os peixes cultivados na menor densidade, 4 kg m², apresentaram melhores taxas de crescimento e ganho de peso (94-96 g em comparação aos mantidos em altas densidades (80-87 g. A taxa de eficiência proteica foi mais elevada a 4 kg m² (1,33-1,36, do que a densidades de 8 kg m² (0,98 ou 14 kg m² (0,45. A ingestão voluntária de alimento decresceu de 0,70 para 0,56% do peso corporal com o incremento da densidade. A suplementação de carnitina não afetou o crescimento e a composição corporal, com exceção do conteúdo de carnitine da carcaça que passou de 75 a 128 mg kg¹. Peixes alimentados com suplementos de 240 mg L-carnitina apresentam excreção de amônia mais baixa comparativamente aos alimentados com 40 mg L-carnitina (p < 0,05.

  12. A COCONUT EXTRA VIRGIN OIL-RICH DIET INCREASES HDL CHOLESTEROL AND DECREASES WAIST CIRCUMFERENCE AND BODY MASS IN CORONARY ARTERY DISEASE PATIENTS.

    Science.gov (United States)

    Cardoso, Diuli A; Moreira, Annie S B; de Oliveira, Glaucia M M; Raggio Luiz, Ronir; Rosa, Glorimar

    2015-11-01

    Introducción: el aceite de coco (Cocos nucifera L.) virgen extra contiene una alta proporción de ácidos grasos de cadena media que parecen contribuir a la reducción del peso y podría ayudar en la prevención secundaria de la enfermedad arterial coronaria (EAC). Objetivo: evaluar el efecto del tratamiento nutricional asociado con el consumo de aceite de coco virgen extra en los parámetros antropométricos y el perfil lipídico. Métodos: se realizó un estudio longitudinal de 116 adultos de ambos sexos que presentan CAD. Los pacientes fueron seguidos en dos etapas: en la primera etapa (basal-3 meses), se llevo a cabo un tratamiento nutricional intensivo. En la segunda etapa (3-6 días), los sujetos fueron divididos en dos grupos: grupo asociado con el consumo de aceite extra virgen de coco (GDOC) y el grupo de dieta (GD). Se realizaron mediciones mensuales antropométricas: peso, circunferencia de la cintura (CC), circunferencia del cuello (PP) e índice de masa corporal (IMC). Se tomó la presión arterial y muestras de sangre recogidas en ayunas durante 12 horas para el análisis de colesterol total y lipoproteínas, apoproteínas (Apo A-1 y B), glucosa, hemoglobina glucosilada (HbA1c) e insulina (I). Se compararon los promedios al principio y al final del estudio mediante el test t de Student-independiente. Se ajustó la presión arterial diastólica por el IMC mediante ANOVA. Los análisis se realizaron con el paquete estadístico SPSS, siendo significativa p infarto de miocardio, el 52,6% con angina de pecho y el 100% con hipertensión arterial y dislipidemia. En la primera etapa del tratamiento nutricional se redujeron las concentraciones de insulina, peso, WC, IMC y PP, HbA1C, HOMA-IR y rápido, sin cambiar otros parámetros. En la segunda etapa del estudio se observó que la GDOC mantiene la reducción del peso, BMI, WC, con una diferencia significativa entre los grupos para DC (-2,1 ± 2,7 cm; p < 0,01). Además, se produjo un aumento en las

  13. Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives

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    M. B. Deshmukh

    2004-01-01

    Full Text Available We describe here an easy and efficient method to obtain S-alkylated derivatives of thio-quinazolinone using different alkylating agents via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazones, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS was used for this purpose. The relationship between structure and different biological activities was studied and the different derivatives were recommended for the screening of some specific activities like anti-tuberculosic, anti-mycobacterial and HDL cholesterol increasing activities.

  14. Aclimatação de mudas de acariquara à alta irradiância Acclimation of manwood seedlings to full sunlight

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    Nilvanda dos Santos Magalhães

    2009-07-01

    Full Text Available O objetivo deste trabalho foi determinar as mudanças fisiológicas que ocorrem em acariquara (Minquartia guianensis durante o processo de aclimatação à alta irradiância, bem como a estratégia de aclimatação dessa espécie. Plantas mantidas em baixa irradiância foram transferidas para alta irradiância por 290 dias. Durante esse período, foi medida a relação entre fluorescência variável e máxima (Fv/Fm, em folhas desenvolvidas à sombra e, após a senescência prematura por foto-oxidação, em folhas aclimatadas ao sol. Ao final do experimento, foram determinadas as características fotossintéticas e anatômicas da folha. A exposição à alta irradiância causou, logo após a transferência, forte fotoinibição e foto-oxidação parcial da folhagem, mas não provocou a morte da planta. Folhas produzidas no ambiente ensolarado apresentaram valores de Fv/Fm similares aos do controle. A fotossíntese saturada por luz e a fotossíntese saturada por CO2 foram 90 e 50% maiores em plantas aclimatadas à alta irradiância. A velocidade máxima de carboxilação da rubisco e a taxa máxima de regeneração da ribulose bisfosfato seguiram a mesma tendência. Folhas produzidas ao sol apresentaram maior densidade estomática e maior espessura foliar. A produção de folhas novas é a principal estratégia de aclimatação da acariquara à alta irradiância.The aim of this work was to determine the physiological changes that occur in manwood (Minquartia guianensis during the acclimation process to high irradiance, and also to determine the acclimation strategy of this species. Plants kept in low light were transferred to high irradiance for 290 days. During this period the ratio between variable fluorescence and maximum fluorescence (Fv/Fm was measured in leaves developed in the shade, and after premature senescence due to photooxidation, in sun-acclimated leaves. At the end of the experimental period the anatomic and photosynthetic

  15. Bone mineral density, vitamin D and anticonvulsant therapy Densidade mineral óssea, vitamina D e terapia anticonvulsivante

    Directory of Open Access Journals (Sweden)

    SILVANA FILARDI

    2000-09-01

    Full Text Available The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy. METHODS: Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were studied, comparing them to thirty healthy controls. Bone mineral density was measured as well as serum levels of calcium, ionized calcium, alkaline phosphatase, PTH, 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol. RESULTS: No differences in bone mineral density, serum levels of vitamin D and intact-PTH were observed between patients and controls. Bone mineral density was not associated with chronic anticonvulsant therapy. CONCLUSION: Those adult patients who were on chronic anticonvulsant therapy and who lived in low latitude regions had normal bone mineral density as well as vitamin D serum levels.O objetivo deste estudo foi avaliar a densidade mineral óssea e o metabolismo da vitamina D em usuários crônicos de anticonvulsivantes. MÉTODOS: Foram estudados 69 pacientes ambulatoriais, masculinos, usuários crônicos de anticonvulsivantes por período mínimo de 5 anos e comparados a 30 controles normais. Foram efetuadas as medidas da densidade mineral óssea e dos níveis plasmáticos do cálcio, cálcio iônico, fosfatase alcalina, paratormônio, 25-hidroxi-colecalciferol e 1,25-di-hidroxi-colecalciferol. RESULTADOS: Nenhuma diferença na densidade mineral óssea e nos níveis plasmáticos da vitamina D e paratormônio foram observadas entre os pacientes e os controles. A densidade mineral óssea não se mostrou associada ao uso crônico de anticonvulsivantes. CONCLUSÕES: Pacientes adultos, do sexo masculino, usuários crônicos de anticonvulsivantes, residentes em regiões ensolaradas, têm densidade mineral óssea e níveis plasmáticos de vitamina D normais.

  16. Hubungan Kadar Trigliserida dan Kolesterol-HDL Terhadap Kadar Alanine Aminotransferase pada Pasien Non Alcoholic Fatty Liver Disease

    Directory of Open Access Journals (Sweden)

    Bayu Gemilang

    2016-01-01

    Full Text Available AbstrakTrigliserida dan Kolesterol HDL (c-HDL merupakan beberapa dari komponen Sindroma Metabolik (SM. SM dipercaya merupakan faktor utama penyebab Non Alcoholic Fatty Liver Disease (NAFLD. NAFLD merupakan penyakit hati kronik yang nantinya dapat menyebabkan fibrosis sel-sel hepar dan juga keganasan. NAFLD tidak menunjukkan manifestasi klinis yang khas, sehingga diperlukan pemeriksaan penunjang seperti pemeriksaan enzim hati untuk menegakkan diagnosis. Alanine Aminotransferase (ALT menjadi pilihan sebagai marker pada penyakit NAFLD. Tujuan penelitian ini adalah menentukan hubungan antara trigliserida dan c-HDL dengan ALT pada penderita NAFLD. Ini merupakan penelitian analitik deskriptif dengan desain retrospektif menggunakan data pasien NAFLD di instalasi rekam medik RSUP dr.M.Djamil Padang. Sampel penelitian ini adalah 51 pasien NAFLD. Hasil penelitian didapatkan dari uji korelasi pearson terdapat derajat hubungan yang kuat (r=0,512 dan hubungan yang bermakna (p<0,001 antara kadar trigliserida dengan kadar ALT serum dan derajat hubungan yang sedang (r=0,26 dan hubungan yang tidak bermakna (p=0,065 antara c-HDL dengan ALT serum. Kesimpulan penelitian ini adalah kadar ALT berhubungan dengan kadar trigliserida pada penderita NAFLD, namun tidak dengan c-HDLKata kunci: NAFLD, trigliserida, HDL, ALT, sindroma metabolik AbstractTriglyceride and HDL Cholesterol (HDL-C are some of the Metabolic Syndrome (MS components. MS is believed as the main factor for the Non Alcoholic Fatty Liver Disease (NAFLD. NAFLD is a chronic liver disease, which later can cause hepatocyte fibrosis and also malignancy. NAFLD does not show a typical clinical appearance, so it is important to do workups such as liver enzyme test to make the diagnosis. Alanine Aminotransferase (ALT is considered as the marker of NAFLD.The objective of this study was to determine the relationship between triglycerides and HDL-C to ALT level in NAFLD patients.This  was a descriptive analytical

  17. Densidades de plantio na produtividade e qualidade de frutos de melancia

    Directory of Open Access Journals (Sweden)

    Anamaria RP Ramos

    2009-12-01

    Full Text Available O experimento foi conduzido na Embrapa Semi-Árido em Petrolina-PE, de setembro a dezembro de 2007, para avaliar o desempenho agronômico e a qualidade dos frutos de melancia cultivadas sob diferentes densidades de plantio. Foram avaliados três espaçamentos combinados com seis cultivares de melancia, sendo duas diplóides de polpa amarela (BRS Soleil e BRS Kuarah, duas triplóides (Híbrido Triplóide CPATSA e Extasy Seedless e duas cultivares comerciais, também diploídes e de fruto pequeno (Smile e Sugar Baby. O delineamento experimental utilizado foi em blocos ao acaso, com esquema fatorial em três repetições. Os tratamentos resultaram da combinação de três espaçamentos (2,0 x 0,3 m; 2,0 x 0,4 m e 2,0 x 0,5 m e seis cultivares de melancia. Foram realizadas duas colheitas, para o Hibrido Triplóide CPATSA e Extasy Seedless, aos 68 DAP (dias após o plantio e 82 DAP. O primeiro e o segundo "corte", respectivamente, para as outras cultivares aconteceram aos 63 DAP e 77 DAP. Avaliaram-se a massa fresca da parte aérea (g, massa média de frutos (g, produção comercial e refugo (g,; diâmetro do fruto (cm, comprimento do fruto (cm, espessura de casca (cm, teor de sólidos solúveis (SS, acidez titulável (AT, relação SS/AT e firmeza da polpa. As análises de variância foram realizadas usando-se o teste F e as médias comparadas através do teste de Tukey ao nível de 5% de probabilidade. De modo geral, os espaçamentos não afetaram a qualidade dos frutos, de modo que o aumento da densidade de plantas permitiu a obtenção de maior produtividade.The experiment was carried out in Petrolina, Pernambuco State, Brazil, from September to December 2007, to evaluate the agronomic performance and fruit quality of watermelon cultivated under different planting densities. Three planting spaces and six cultivars were evaluated, where two cultivars were of yellow pulp (BRS Soleil and BRS Kuarah, two cultivars were triploid (Triploid Hybrid

  18. HDL-related mechanisms of olive oil protection in cardiovascular disease.

    Science.gov (United States)

    Lou-Bonafonte, José M; Fitó, Montse; Covas, María-Isabel; Farràs, Marta; Osada, Jesús

    2012-07-01

    The low incidence of cardiovascular disease in countries bordering the Mediterranean basin, where olive oil is the main source of dietary fat, and the negative association between this disease with high density lipoproteins has stimulated interest. This review summarizes the current knowledge gathered from human and animal studies regarding olive oil and high density lipoproteins. Cumulative evidence suggests that high density lipoprotein (HDL) cholesterol, and its main apolipoprotein A1, may be increased by consuming olive oil when compared with carbohydrate and low fat diets in humans. Conflicting results have been found in many studies when olive oil diets were compared with other sources of fat. The role of virgin olive oil minor components on its protective effect has been demonstrated by a growing number of studies although its exact mechanism remains to be elucidated. Dietary amount of olive oil, use of virgin olive oil, cholesterol intake, and physiopathological states such as genetic background, sex, age, obesity or fatty liver are variables that may offset those effects. Further studies in this field in humans and in animal models are warranted due to the complexity of HDL particles.

  19. Beyond LDL-Cholesterol: New Treatments Raising HDL-Cholesterol or Enhancing Reverse Cholesterol Transport

    Directory of Open Access Journals (Sweden)

    Kostner K

    2002-01-01

    Full Text Available Neue Therapiekonzepte zur Beeinflussung der HDL. Atheroskleroseassoziierte Erkrankungen sind weltweit immer noch die Todesursache Nummer 1. Heute stehen uns eine Reihe von Therapiemöglichkeiten, wie Diät, Statine oder LDL-Apherese, zur Verfügung, welche zu einer signifikanten LDL-Reduktion führen. Trotz exzellenter Risikoreduktion sowohl in der Primär- als auch in der Sekundärprävention, sind kardiovaskuläre Mortalität und Morbidität nach wie vor eine große Herausforderung für Ärzte und unser Gesundheitssystem. Deshalb besteht ein klarer Bedarf an neuen Interventionsmöglichkeiten. High Density Lipoproteine sind ein möglicher Ansatzpunkt, und deshalb möchte ich in diesem Reviewartikel alte und neue Strategien zur Erhöhung von HDL beleuchten und 2 neue Therapieansätze, die zur Zeit klinisch getestet werden, vorstellen.

  20. Temporal Stability of the Velodyne HDL-64E S2 Scanner for High Accuracy Scanning Applications

    Directory of Open Access Journals (Sweden)

    Craig Glennie

    2011-03-01

    Full Text Available The temporal stability and static calibration and analysis of the Velodyne HDL‑64E S2 scanning LiDAR system is discussed and analyzed. The mathematical model for measurements for the HDL-64E S2 scanner is updated to include misalignments between the angular encoder and scanner axis of rotation, which are found to be a marginally significant source of error. It is reported that the horizontal and vertical laser offsets cannot reliably be obtained with the current calibration model due to their high correlation with the horizontal and vertical offsets. By analyzing observations from two separate HDL-64E S2 scanners it was found that the temporal stability of the horizontal angle offset is near the quantization level of the encoder, but the vertical angular offset, distance offset and distance scale are slightly larger than expected. This is felt to be due to long term variations in the scanner range, whose root cause is as of yet unidentified. Nevertheless, a temporally averaged calibration dataset for each of the scanners resulted in a 25% improvement in the 3D planar misclosure residual RMSE over the standard factory calibration model.

  1. Very low levels of HDL cholesterol and atherosclerosis, a variable relationship – a review of LCAT deficiency

    Directory of Open Access Journals (Sweden)

    Savel J

    2012-06-01

    Full Text Available Julia Savel,1,2 Marianne Lafitte,1 Yann Pucheu,1,3 Vincent Pradeau,1 Antoine Tabarin,2,3 Thierry Couffinhal1,3,41Centre d'Exploration, de Prévention et de Traitement de l'Athérosclérose, Hôpital Cardiologique, 2Service d'endocrinologie, CHU Bordeaux, Université Bordeaux Segalen, Bordeaux, France; 3Université de Bordeaux Adaptation cardiovasculaire à l'ischémie, 4INSERM, Adaptation cardiovasculaire à l'ischémie, U1034, Pessac, FranceAbstract: A number of epidemiological and clinical studies have demonstrated that plasma high-density lipoprotein (HDL level is a strong inverse predictor of cardiovascular events. HDL is believed to retard the formation of atherosclerotic lesions by removing excess cholesterol from cells and preventing endothelial dysfunction. Lecithin cholesterol acyltransferase (LCAT plays a central role in the formation and maturation of HDL, and in the intravascular stage of reverse cholesterol transport: a major mechanism by which HDL modulates the development and progression of atherosclerosis. A defect in LCAT function would be expected to enhance atherosclerosis, by interfering with the reverse cholesterol transport step. As such, one would expect to find more atherosclerosis and cardiovascular events in LCAT-deficient patients. But this relationship is not always evident. In this review, we describe contradictory reports in the literature about cardiovascular risks in this patient population. We discuss the paradoxical finding of severe HDL deficiency and an absence of subclinical atherosclerosis in LCAT-deficient patients, which has been used to reject the hypothesis that HDL level is important in the protection against atherosclerosis. Furthermore, to illustrate this paradoxical finding, we present a case study of one patient, referred for evaluation of global cardiovascular risk in the presence of a low HDL cholesterol level, who was diagnosed with LCAT gene mutations.Keywords: atherosclerosis, LCAT function

  2. Comparison of vegetarian diets and omnivorous diets on plasma level of HDL-c: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Zili Zhang

    Full Text Available Low plasma level of high density lipoprotein cholesterol (HDL-c was an independent risk factor for cardio vascular disorder, and associated with poor outcomes in pulmonary arterial hypertension. To compare the effects of vegetarian diets and omnivorous diets on HDL-c in plasma, we identified cross-sectional and cohort studies related to HDL-c listed on PubMed and ISI Web of Knowledge as well as the corresponding references (until Nov, 2013. Twelve studies with a total of 4177 individuals were selected for meta-analysis. This meta-analysis indicates that vegetarian diets did not alter plasma HDL-c concentrations, as it wasn't initially expected by the authors [Standardized Mean Difference (SMD = 0.02 mmol/l; 95% confidence interval (CI: -0.19 to 0.22 mmol/l]. In Asia and Latin America countries, no significant differences in HDL-c levels between vegetarians and omnivores were found (SMD = -0.09 mmol/l; 95% CI: -0.43 to 0.25 mmol/l. In Europe and North America countries, the plasma level of HDL-c was also not different between the two diets (SMD = 0.09 mmol/l; 95% CI: -0.19 to 0.36 mmol/l. In light of this meta-analysis, we conclude that there is no evidence that plasma HDL-c levels differs in vegetarians and omnivores, even after adjusting for cultural circumstances.

  3. Non-HDL-cholesterol as valid surrogate to apolipoprotein B100 measurement in diabetes: Discriminant Ratio and unbiased equivalence

    Directory of Open Access Journals (Sweden)

    Ahn Sylvie A

    2011-02-01

    Full Text Available Abstract Background Apolipoprotein B100 (apoB is a superior indicator of CV risk than total or LDL-C. Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high correlation, although the degree of mutual concordance remains debated in CV risk evaluation. Objectives We used the Discriminant Ratio (DR methodology to compare the performance of non-HDL-C with that of apoB to rank diabetic patients according to dyslipidemia and to establish the underlying relationship between these variables taking measurement noise and intra-/intersubject variation into account, and to derive an unbiased equivalence equation. Methods Fasting total C, HDL-C, apoB and triglycerides were measured in 45 diabetic patients. The DR of the underlying between-subject standard deviation (SD to the within-subject SD was calculated from duplicates. Correlation coefficients between pairs were adjusted to include an estimate of the underlying correlation. Results Mean values [day 1 (1SD] were 143 (36 mg/dl (non-HDL-C and 98 (24 mg/dl (apoB. The DR's of both parameters were similar (1.76 and 1.83 (p = 0.83. Pearson's product-moment correlation coefficient between tests was very high (0.94, reaching unity (1.00 after attenuation adjustment. The unbiased equation of equivalence relating apoB to non-HDL-C had a slope of 0.65 and an intercept of 6.3 mg/dl. Conclusions The discrimination power of non-HDL-C is similar to that of apoB to rank diabetic patients according to atherogenic cholesterol and lipoprotein burden. Since true correlation between variables reached unity, non-HDL-C may provide not only a metabolic surrogate but also a candidate biometrical equivalent to apoB, as non-HDL-C calculation is readily available.

  4. The Effects of Sino - implant Containing LNG on Lipoprotein Metabolism and Changes in Blood HDL2-C Levels

    Institute of Scientific and Technical Information of China (English)

    杨培娟; 吴学浙; 杨秋英; 蔡红珍; 李慧沁

    1999-01-01

    The effects of the domestically manufactured contraceptive, Sino-implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL2-C levels were evaluated in 20 healthy reproductive-aged volunteers, during cycles after implantation. Results show that the levels of lipids, lipoproteins and apolipoproteins were reduced to different degrees during the 12 treatment cycles. A significant decrease was observed in the serum levels of triglycerides (TG, P~ O. 05) and apolipoprotein A I(apo A I , P<0. 05) during treatment cycles. However these values increased again at the end of the 12th cycle. High density lipoprotein 2-cholesterel (HDL2) decreased significantly (P<0. 05), only during the 8rd and 12th cycle. These results indicate that Sino-implants containing LNG exerts an influence on reducing the levels of TG,apo A I and HDL,, but those values could return gradually as the released drug dose decreased and then became unchanged. On the other hand, the mechanism of the low HDL2-C level induced by Sino-implant is different from that of low HDL2-C level in patients with coronary heart disease. The conclusion is: there is no obvious side effect on lipid metabolism during treatment with the Sino-implant.

  5. Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage.

    Science.gov (United States)

    Berrougui, Hicham; Isabelle, Maxim; Cherki, Mounia; Khalil, Abdelouahed

    2006-12-14

    The objective of the present study was to elucidate the beneficial properties of aqueous extracts of Marrubium vulgare (AEM) towards cardiovascular disease by protecting human-LDL against lipid peroxidation and promoting HDL-mediated cholesterol efflux. Human-LDL were oxidised by incubation with CuSO(4) in the presence of increased concentrations of AEM (0-100 microg/ml). LDL lipid peroxidation was evaluated by conjugated diene formation, vitamin E disappearance as well as LDL-electrophoretic mobility. HDL-mediated cholesterol efflux assay was carried out in human THP-1 macrophages. Incubation of LDL with AEM significantly prolonged the lag phase (P=0.014), lowered the progression rate of lipid peroxidation (P=0.004), reduced the disappearance of vitamin E and the electrophoretic mobility in a dose-dependent manner. Also, incubation of HDL with AEM significantly increased HDL-mediated cholesterol efflux from THP-1 macrophages implicating an independent ATP binding cassette A1 (ABCA1) pathways. Our findings suggest that M. vulgare provides a source of natural antioxidants, which inhibit LDL oxidation and enhance reverse cholesterol transport and thus can prevent cardiovascular diseases development. These antioxidant properties increase the anti-atherogenic potential of HDL. PMID:17045616

  6. Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage.

    Science.gov (United States)

    Berrougui, Hicham; Isabelle, Maxim; Cherki, Mounia; Khalil, Abdelouahed

    2006-12-14

    The objective of the present study was to elucidate the beneficial properties of aqueous extracts of Marrubium vulgare (AEM) towards cardiovascular disease by protecting human-LDL against lipid peroxidation and promoting HDL-mediated cholesterol efflux. Human-LDL were oxidised by incubation with CuSO(4) in the presence of increased concentrations of AEM (0-100 microg/ml). LDL lipid peroxidation was evaluated by conjugated diene formation, vitamin E disappearance as well as LDL-electrophoretic mobility. HDL-mediated cholesterol efflux assay was carried out in human THP-1 macrophages. Incubation of LDL with AEM significantly prolonged the lag phase (P=0.014), lowered the progression rate of lipid peroxidation (P=0.004), reduced the disappearance of vitamin E and the electrophoretic mobility in a dose-dependent manner. Also, incubation of HDL with AEM significantly increased HDL-mediated cholesterol efflux from THP-1 macrophages implicating an independent ATP binding cassette A1 (ABCA1) pathways. Our findings suggest that M. vulgare provides a source of natural antioxidants, which inhibit LDL oxidation and enhance reverse cholesterol transport and thus can prevent cardiovascular diseases development. These antioxidant properties increase the anti-atherogenic potential of HDL.

  7. TransAlta Corporation 1996 annual report : new directions, new opportunities

    International Nuclear Information System (INIS)

    TransAlta Corp. is an energy management company that operates through two subsidiaries: (1) TransAlta Utilities Corp. which owns and operates electricity generation, transmission and distribution assets in Alberta, and (2) TransAlta Energy Corp. which is in the business of electric and thermal energy supply, gas and electricity distribution, energy services and energy marketing in regions of Canada, New Zealand, Australia, Argentina and the United States. This report presents a summary of operations, and provides consolidated financial statements and common share information for 1996. During the year the corporation advanced three significant initiatives (1) operational effectiveness, as shown by impressive productivity increases, and major investments in three independent power projects, (2) improved strategic direction through a review of plans and options, resulting in a clearer, more focused vision of the future, and (3) realignment of the organizational structure by centralizing marketing and sales functions, and establishing a corporate business development group. Details of operational and financial results were provided for both subsidiaries, i. e. TransAlta Utilities and TransAlta Energy. Sales of electric energy for TransAlta Utilities amounted to 27.8 billion kWh; 4.6 billion kWh for TransAlta Energy. Return on equity was 11.4 per cent, down from 11.8 per cent in 1995. Net earnings per common share were $1.14 per share (including one-time items), the same as in 1995. tabs., figs

  8. Monitorización del estrés hídrico en un olivar en seto de alta densidad con sondas de presión de turgencia en hojas

    OpenAIRE

    Rodríguez Domínguez, Celia M.

    2011-01-01

    70 páginas.-- 15 figuras.-- 1 tabla.-- 71 referencias.-- Curso 2010-2011. Trabajo de iniciación a la investigación. Memoria para optar al Diploma de Estudios Avanzados por la Universidad de Sevilla. Línea de investigación "Efecto medioambiental de los fertilizantes y el riego en la agricultura"

  9. Características de compósitos laminados manufaturados com polietileno de alta densidade (PEAD e diferentes proporções de casca de arroz e partículas de madeira

    Directory of Open Access Journals (Sweden)

    Dalva Teresinha Pauleski

    2007-01-01

    Full Text Available The objective of this work was to analyse the feasibility of the utilization of rice husks and wood particles in the manufacture of wood plastic composites, in a way similar to particleboard fabrication. The composites were made with rice husks and Eucalyptus grandis wood particles, pure or mixed, in proportions of 0, 25, 50, 75 and 100% of ovendry weight. High density polyethylene (HDPE was used as matrix in the manufacture in three proportions: 60, 75, and 90%. Bending properties, internal bond, water absorption and thickness swelling after 24 hours of water soaking and after 15 soaking cycles were evaluated. The values of bending properties were influenced by the density of the composite. In the case of internal bond, the values were within the limits established by commercial particleboard standards, being the HDPE proportion the parameter of higher correlation with this property. Rice husk caused lower thickness swelling and, independently of the type of raw material utilised, the values decreased with the increase of HDPE. Combinations with larger percentages of HDPE presented minimal values or, in some cases, null of water absorption. For the water absorption and thickness swelling after 15 cycles the behavior was similar to that of the 24 hour period. Results allowed concluding that the composites made with HDPE, rice husks and wood particles pure or mixed present good quality, evidencing the adequacy of these raw material and process in manufacturing this type of panel.

  10. Higher glandular trichome density in tomato leaflets and repellence to spider mites Alta densidade de tricomas glandulares em tomateiro e aumento da repelência a ácaros rajados

    OpenAIRE

    Wilson Roberto Maluf; Irene Fumi Inoue; Raphael de Paula Duarte Ferreira; Luiz Antonio Augusto Gomes; Evaristo Mauro Castro; Maria das Graças Cardoso

    2007-01-01

    The objective of this work was to evaluate the feasibility of selection for higher glandular trichome densities, as an indirect criterion of selection for increasing repellence to spider mites Tetranychus urticae, in tomato populations derived from an interspecific cross between Lycopersicon esculentum x L. hirsutum var. glabratum PI 134417. Trichome densities were evaluated in 19 genotypes, including 12 from advanced backcross populations, derived from the original cross L. esculentum x L. h...

  11. Dosimetry characterization and clinical application of Exa skin: Bolus of high of high density for use with photons; Caracterizacion dosimetrica y aplicacion clinica de Exaskin: bolus de alta densidad para uso con fotones

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz Seidel, M.; Velazquez Miranda, S.

    2013-07-01

    Bolus of high density eXaSkin of density 1.6 g/cm{sub 3} is calculated correctly in the planning systems, is easy to use and generates optimum coupling with the radiation area, at the same time which is easily reproducible in their placement, avoiding the use of electron beams. On the other hand its behavior varies very slightly with the presence of air gaps. (Author)

  12. Preparation and characterization of high density polyethylene and residual fibre of Attalea funifera Mart (piacava) composites; Preparacao e caracterizacao de compositos de polietileno de alta densidade com residuos de fibras de piacava da especie Attalea funifera Mart

    Energy Technology Data Exchange (ETDEWEB)

    Agrela, Sara P.; Guimaraes, Danilo H.; Jose, Nadia M., E-mail: saraagrela@hotmail.co [Universidade Federal da Bahia (GECIM/IQ/UFBA), Salvador, BA (Brazil). Inst. de Quimica. Grupo de Energia e Ciencias dos Materiais; Carvalho, Gleidson G.P. [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil). Escola de Medicina Veterinaria. Dept. de Producao Animal; Carvalho, Ricardo F. [Universidade Federal da Bahia (EP/UFBA), Salvador, BA (Brazil). Escola Politecnica. Curso de Mestrado em Engenharia Ambiental Urbana

    2009-07-01

    The use of natural fiber reinforcement thermoplastic polymer is continuously increasing. This fact is manly due to its advantages as low cost, availability, recyclability, low energy demand and then environmental appeal if compared to synthetics fibers. The composites were prepared in different fiber volume ratios (5%, 10% and 20%) mixed with high density polyethylene (HDPE) and heated at 190 deg C. Thermogravimetric analysis and differential scanning calorimetry were used to investigate thermal stability. The composites structure was characterized by Fourier Transform Infrared spectroscopy, X-ray diffractometry. Fiber and residue of piassava (Attalea funifera Mart) chemical composition were determined by Van Soest Method. The results indicate that thermo stability of the composites of HDPE prepared with fiber volume ratios up to 20% is only slightly lowered. (author)

  13. Temporal Analysis and Automatic Calibration of the Velodyne HDL-32E LiDAR System

    Science.gov (United States)

    Chan, T. O.; Lichti, D. D.; Belton, D.

    2013-10-01

    At the end of the first quarter of 2012, more than 600 Velodyne LiDAR systems had been sold worldwide for various robotic and high-accuracy survey applications. The ultra-compact Velodyne HDL-32E LiDAR has become a predominant sensor for many applications that require lower sensor size/weight and cost. For high accuracy applications, cost-effective calibration methods with minimal manual intervention are always desired by users. However, the calibrations are complicated by the Velodyne LiDAR's narrow vertical field of view and the very highly time-variant nature of its measurements. In the paper, the temporal stability of the HDL-32E is first analysed as the motivation for developing a new, automated calibration method. This is followed by a detailed description of the calibration method that is driven by a novel segmentation method for extracting vertical cylindrical features from the Velodyne point clouds. The proposed segmentation method utilizes the Velodyne point cloud's slice-like nature and first decomposes the point clouds into 2D layers. Then the layers are treated as 2D images and are processed with the Generalized Hough Transform which extracts the points distributed in circular patterns from the point cloud layers. Subsequently, the vertical cylindrical features can be readily extracted from the whole point clouds based on the previously extracted points. The points are passed to the calibration that estimates the cylinder parameters and the LiDAR's additional parameters simultaneously by constraining the segmented points to fit to the cylindrical geometric model in such a way the weighted sum of the adjustment residuals are minimized. The proposed calibration is highly automatic and this allows end users to obtain the time-variant additional parameters instantly and frequently whenever there are vertical cylindrical features presenting in scenes. The methods were verified with two different real datasets, and the results suggest that up to 78

  14. Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

    OpenAIRE

    Herman J. Kempen; Schranz, Dorota B.; Asztalos, Bela F.; James Otvos; Elias Jeyarajah; Denise Drazul-Schrader; Collins, Heidi L.; Adelman, Steven J.; Wijngaard, Peter L. J.

    2014-01-01

    MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high density lipoprotein (prebeta-1 HDL) and on HDL size assessed by proton nuclear magnetic resonance (1H-NMR). MDCO-216 incubated in buffer containing 4% human serum albumin stimulated both ABCA1-media...

  15. Altas Capacidades en Educación Infantil en Guipúzcoa

    OpenAIRE

    Omaetxebarria-Aldarono, Ainara

    2013-01-01

    El trabajo fin de grado que se presenta a continuación aporta información acerca de las altas capacidades en Educación Infantil y su relación con las inteligencias múltiples. Se propone una perspectiva de la realidad actual del tema en el contexto de la provincia de Guipúzcoa. Las altas capacidades se proponen aludiendo a varios aspectos, entre ellos, se define el término, se aportan características de los alumnos con altas capacidades, se señalan alternativas de intervención en las aulas y s...

  16. Altas capacidades intelectuales. Diagnóstico y seguimiento de una NEE.

    OpenAIRE

    Pérez-i-Martra, Pep

    2013-01-01

    Según la OMS, el 2,3% de la población mundial tiene altas capacidades intelectuales, es decir, en la vida académica de un profesor, éste tendría que descubrir una media de 40 alumnos con capacidades superiores a la media. Saber en qué consisten las altas capacidades y hacer un pre diagnóstico de las mismas será, en muchas ocasiones, trabajo del profesor de secundaria. Pero, ¿tiene éste conocimientos para percatarse de la presencia en clase de un alumno con altas capacidades? ¿Y una vez estudi...

  17. El alumnado con altas capacidades intelectuales: programas de intervención.

    OpenAIRE

    González Arranz, Raquel

    2015-01-01

    El presente Trabajo de Fin de Grado se centra en alumnos considerados de Educación Especial, concretamente en aquellos que poseen Altas Capacidades Intelectuales y las posibilidades de respuesta educativa que se les puede ofrecer dentro del modelo de aula ordinaria. En la primera parte, se afronta el estudio de alumnos con altas capacidades intelectuales en educación primaria. Los temas que se tratan son: conceptualización y definiciones, fundamentación teórica de alumnos con altas capaci...

  18. Espondiloartritis y su relación con las fracturas vertebrales y la densidad mineral ósea

    OpenAIRE

    Sánchez González, María Dolores

    2016-01-01

    [ES] En el presente trabajo se estudia la espondilitis anquilosante (EA), enfermedad inflamatoria crónica más común en varones, y la relación de la misma con las fracturas vertebrales y la densidad mineral ósea, debido a que en los varonos como resultado de una respuesta inmune, se produce una inflamación en las articulaciones sacroiliacas, vertebrales y otras adyacentes. Es frecuente que los pacientes también tengan inflamación en las entesis (inserción del tendón o del ligamento en el hues...

  19. Densidad ósea y frecuencias de restos humanos en Tierra del Fuego. Análisis exploratorio

    OpenAIRE

    Suby, Jorge A.; Guichón, Ricardo Aníbal

    2003-01-01

    La disponibilidad del registro biológico humano para su estudio esta condicionada por procesos paleoecológicos y tafonómicos. Cuales probablemente van a ser los especimenes mejor y peor representados constituye un dato importante al momento de decidir que preguntar. En relación con esta problemática nos interesa explorar la relación entre la densidad mineral ósea y las frecuencias relativas con que se presenta el registro biológico humano en varias colecciones del norte de Tierra del Fuego. L...

  20. Densidad del Mono aullador Alouatta seniculus (Linnaeus, 1766) Mammalia: primates en el arroyo coloso, Departamento de Sucre, Colombia

    OpenAIRE

    Fajardo Patiño Alirio; De la Ossa Velasquez Jaime L.

    1996-01-01

    Nueve manadas de Alouatta seniculus, fueron estudiadas a lo largo de tres meses y medio, entre Mayo y Agosto de 1983. Se tomaron en cuenta aspectos relativos al estado y densidad poblacional en el Arroyo Colosó, Departamento de Sucre. Se establece una relación de los datos obtenidos y procesados en este trabajo con los suministrados por otros autores en estudios similares con la misma especie y en diferentes lugares.Nine troops of Alouatta seniculus, were studied for a period of three and hal...

  1. Densidad y biomasa de Pterois volitans/miles (Teleostei: Scorpaenidae) en arrecifes del litoral oeste de La Habana, Cuba

    OpenAIRE

    García-Rodríguez, Alain; Chevalier Monteagudo, Pedro P.; Cabrera Sansón, Erlán; Caballero Aragón, Hansel; Luis Hernández López, Jorge

    2015-01-01

    El pez león (Pterois volitans/miles) es la primera especie (s) de pez arrecifal del Indo- Pacífico que invade el Atl{ntico Occidental, constituyendo una de las invasiones de peces marinos m{s r{pida de la historia. El objetivo fue determinar la densidad y biomasa de las poblaciones del pez león y sus posibles variaciones temporales y espaciales en arrecifes del oeste de La Habana, Cuba. Los muestreos fueron realizados mediante censos visuales con buceo autónomo en los períodos ...

  2. Verification and Diagnosis Infrastructure of SoC HDL-model

    CERN Document Server

    Hahanov, Vladimir; Litvinova, Eugenia; Chumachenko, Svetlana

    2012-01-01

    This article describes technology for diagnosing SoC HDL-models, based on transactional graph. Diagnosis method is focused to considerable decrease the time of fault detection and memory for storage of diagnosis matrix by means of forming ternary relations in the form of test, monitor, and functional component. The following problems are solved: creation of digital system model in the form of transaction graph and multi-tree of fault detection tables, as well as ternary matrices for activating functional components in tests, relative to the selected set of monitors; development of a method for analyzing the activation matrix to detect the faults with given depth and synthesizing logic functions for subsequent embedded hardware fault diagnosing.

  3. Design hardware calculator in PWM peripherals of nios Ⅱ with verilog HDL

    Institute of Scientific and Technical Information of China (English)

    XU Yang; XIANG Min

    2009-01-01

    The Plus Width Module (PWM) in microprocessors is commonly used in motor control field. If the ordinary PWM peripherals output PWM waveform, the software must calculate the period and duty cycle number based on the microprocessor's system clock cycle first, and then write them into the registers. As all known, the microprocessor without hardware calculator consume very long time in multiplication and division. In order to reduce the CPU's running time, a calculation hardware unit was designed to calculate the waveform parameters. The software only need to write the period (Hz units) to the period register and the duty cycle (% units)to its register. This hardware unit was designed with Verilog HDL and running in the Nios II system successfully.

  4. Anti-ATP synthase autoantibodies from patients with Alzheimer's disease reduce extracellular HDL level.

    Science.gov (United States)

    Vacirca, Davide; Barbati, Cristiana; Scazzocchio, Beatrice; Masella, Roberta; Rosano, Giuseppe; Malorni, Walter; Ortona, Elena

    2011-01-01

    Aside from being an integral protein involved in the synthesis and hydrolysis of ATP, Ecto-F1-ATPase plays a role in cholesterol homeostasis. We demonstrated the presence of autoantibodies to ecto-F1-ATPase (ASabs) in sera and cerebrospinal fluids from patients with Alzheimer's disease (AD). Herein we show that ASabs, unlike irrelevant antibodies, can increase cellular uptake of HDL, a risk factor for the development of AD, via a mechanism involving the prototypical function of ecto-F1-ATPase: the generation of ADP due to the hydrolysis of ATP. Piceatannol, a specific inhibitor ecto-F1-ATPase, completely hindered these effects. We hypothesize that ASabs could exert a pathogenetic role in AD. PMID:21677380

  5. Impacto do exercício físico isolado e combinado com dieta sobre os níveis séricos de HDL, LDL, colesterol total e triglicerídeos Impact of isolated and combined with diet physical exercise on the HDL, LDL, total cholesterol and triglycerides plasma levels

    Directory of Open Access Journals (Sweden)

    Sanmira Fagherazzi

    2008-08-01

    Full Text Available Adequados hábitos alimentares e a prática de exercícios físicos exercem efeito benéfico sobre as dislipidemias. Se associados, podem ainda otimizar as mudanças do perfil lipoprotéico plasmático, sendo, além disso, intervenções de custo moderado quando comparados com tratamentos medicamentosos e dependentes de alta tecnologia. Este estudo tem por objetivo avaliar o impacto do exercício físico isolado e combinado com dieta sobre o perfil lipídico em indivíduos com sobrepeso/obesos. O presente trabalho é do tipo retrospectivo analítico observacional. Nele foi analisada a evolução do perfil lipídico e do peso, por período entre três e seis meses, de 30 indivíduos, divididos em dois grupos: grupo exercício (prática de exercício físico e grupo dieta (prática de exercício físico associada à intervenção nutricional. Foram encontradas reduções estatisticamente significativas no CT (-14,4mg/dl; P = 0,022 e no LDL-c (-20,9mg/dl; P = 0,013 para os componentes do grupo exercício. Tal redução também ocorreu em relação à razão CT/HDL-c (-0,9; P = 0,005 para os componentes do grupo dieta. Foi observada elevação dos níveis de HDL-c, apenas no grupo dieta (+4,2 mg/dl. Nesse mesmo grupo verificou-se diminuição no CT (-8mg/dl e no LDL-c (-9,8mg/dl, bem como redução de peso (-2,6kg, no entanto, tais resultados não foram estatisticamente significativos. Quanto aos níveis de TG, não foi verificada evolução positiva em ambos os grupos. Concluiu-se que o efeito isolado do exercício físico foi mais evidente em relação às variáveis CT e LDL-c. Os TG não sofreram modificações positivas com a prática exclusiva de exercícios físicos ou com sua associação à dieta. Para as variáveis HDL-c e peso, a combinação da dieta com o exercício físico apresentou maiores benefícios.Adequate eating habits and physical exercise have a beneficial effect on dislipidemies. When associated, they might even optimize

  6. Plasma kinetics of an LDL-like nanoemulsion and lipid transfer to HDL in subjects with glucose intolerance

    Directory of Open Access Journals (Sweden)

    Marina P Bertato

    2012-01-01

    Full Text Available OBJECTIVE: Glucose intolerance is frequently associated with an altered plasma lipid profile and increased cardiovascular disease risk. Nonetheless, lipid metabolism is scarcely studied in normolipidemic glucose-intolerant patients. The aim of this study was to investigate whether important lipid metabolic parameters, such as the kinetics of LDL free and esterified cholesterol and the transfer of lipids to HDL, are altered in glucose-intolerant patients with normal plasma lipids. METHODS: Fourteen glucose-intolerant patients and 15 control patients were studied; none of the patients had cardiovascular disease manifestations, and they were paired for age, sex, race and co-morbidities. A nanoemulsion resembling a LDL lipid composition (LDE labeled with 14C-cholesteryl ester and ³H-free cholesterol was intravenously injected, and blood samples were collected over a 24-h period to determine the fractional clearance rate of the labels by compartmental analysis. The transfer of free and esterified cholesterol, triglycerides and phospholipids from the LDE to HDL was measured by the incubation of the LDE with plasma and radioactivity counting of the supernatant after chemical precipitation of non-HDL fractions. RESULTS: The levels of LDL, non-HDL and HDL cholesterol, triglycerides, apo A1 and apo B were equal in both groups. The 14C-esterified cholesterol fractional clearance rate was not different between glucose-intolerant and control patients, but the ³H-free-cholesterol fractional clearance rate was greater in glucose-intolerant patients than in control patients. The lipid transfer to HDL was equal in both groups. CONCLUSION: In these glucose-intolerant patients with normal plasma lipids, a faster removal of LDE free cholesterol was the only lipid metabolic alteration detected in our study. This finding suggests that the dissociation of free cholesterol from lipoprotein particles occurs in normolipidemic glucose intolerance and may participate in

  7. Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats

    Directory of Open Access Journals (Sweden)

    Neves Valdir A

    2011-09-01

    Full Text Available Abstract Background This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin, in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals. Methods Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9: 1 standard (STD: fed on casein as protein source; 2 hypercholesterolemic (HC: STD plus 1% cholesterol and 0.5% cholic acid; 3 HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day; 4 HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day; 5 HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3 and (4. The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain. Results A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet. Conclusion Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin and the protein (glycinin were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism.

  8. 9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages

    Directory of Open Access Journals (Sweden)

    Sapir Bechor

    2016-07-01

    Full Text Available Cholesterol efflux from macrophages is a key process in reverse cholesterol transport and, therefore, might inhibit atherogenesis. 9-cis-β-carotene (9-cis-βc is a precursor for 9-cis-retinoic-acid (9-cis-RA, which regulates macrophage cholesterol efflux. Our objective was to assess whether 9-cis-βc increases macrophage cholesterol efflux and induces the expression of cholesterol transporters. Enrichment of a mouse diet with βc from the alga Dunaliella led to βc accumulation in peritoneal macrophages. 9-cis-βc increased the mRNA levels of CYP26B1, an enzyme that regulates RA cellular levels, indicating the formation of RA from βc in RAW264.7 macrophages. Furthermore, 9-cis-βc, as well as all-trans-βc, significantly increased cholesterol efflux to high-density lipoprotein (HDL by 50% in RAW264.7 macrophages. Likewise, food fortification with 9-cis-βc augmented cholesterol efflux from macrophages ex vivo. 9-cis-βc increased both the mRNA and protein levels of ABCA1 and apolipoprotein E (APOE and the mRNA level of ABCG1. Our study shows, for the first time, that 9-cis-βc from the diet accumulates in peritoneal macrophages and increases cholesterol efflux to HDL. These effects might be ascribed to transcriptional induction of ABCA1, ABCG1, and APOE. These results highlight the beneficial effect of βc in inhibition of atherosclerosis by improving cholesterol efflux from macrophages.

  9. 9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages

    Science.gov (United States)

    Bechor, Sapir; Zolberg Relevy, Noa; Harari, Ayelet; Almog, Tal; Kamari, Yehuda; Ben-Amotz, Ami; Harats, Dror; Shaish, Aviv

    2016-01-01

    Cholesterol efflux from macrophages is a key process in reverse cholesterol transport and, therefore, might inhibit atherogenesis. 9-cis-β-carotene (9-cis-βc) is a precursor for 9-cis-retinoic-acid (9-cis-RA), which regulates macrophage cholesterol efflux. Our objective was to assess whether 9-cis-βc increases macrophage cholesterol efflux and induces the expression of cholesterol transporters. Enrichment of a mouse diet with βc from the alga Dunaliella led to βc accumulation in peritoneal macrophages. 9-cis-βc increased the mRNA levels of CYP26B1, an enzyme that regulates RA cellular levels, indicating the formation of RA from βc in RAW264.7 macrophages. Furthermore, 9-cis-βc, as well as all-trans-βc, significantly increased cholesterol efflux to high-density lipoprotein (HDL) by 50% in RAW264.7 macrophages. Likewise, food fortification with 9-cis-βc augmented cholesterol efflux from macrophages ex vivo. 9-cis-βc increased both the mRNA and protein levels of ABCA1 and apolipoprotein E (APOE) and the mRNA level of ABCG1. Our study shows, for the first time, that 9-cis-βc from the diet accumulates in peritoneal macrophages and increases cholesterol efflux to HDL. These effects might be ascribed to transcriptional induction of ABCA1, ABCG1, and APOE. These results highlight the beneficial effect of βc in inhibition of atherosclerosis by improving cholesterol efflux from macrophages. PMID:27447665

  10. Il programma italiano di ricerche nella alta atmosfera

    Directory of Open Access Journals (Sweden)

    l. BROGLIO

    1962-06-01

    Full Text Available La Commissione per le Ricerche Spaziali, nominata dal ConsiglioNazionale delle Ricerche diciotto mesi fa, ha intrapreso un programmadi studio dell'alta atmosfera a mezzo di razzi sonda. Questa ricerca,che nella attuale prima fase di lavoro e sviluppo deve essere consideratauna delle attività basilari della Commissione, aveva ed ha un duplicescopo: uno scopo diretto, immediato, che consiste nell'acquisizione didati scientifici, in maggior copia possibile, tali da ampliare ed approfondirele attuali conoscenze sulla struttura e sulla dinamica della altaatmosfera.Il secondo scopo è, se così si può dire, proiettato nel futuro. L'organizzazionepredisposta, sia in uomini che in attrezzature ed installazioni,per questa ricerca può considerarsi infatti come il nocciolo di unapiù ampia organizzazione che potrà operare negli anni successivi permaggiori e più impegnativi compiti.I fondi necessari per lo sviluppo del programma di ricerche nell'altaatmosfera sono stati forniti alla Commissione delle Ricerche Spazialiin base ad un accordo fra il C.N.R. e il Comitato Razzi e Missili delMinistero della Difesa, secondo il quale i due Enti si impegnavano acontribuire alle spese necessarie su base paritetica.II C.N.R. stipulò anche un accordo di natura scientifica con l'Entespaziale statunitense N.A.S.A., sia per ottenere dalla Commissione delleRicerche Spaziali un appoggio tecnico, sia per altre finalità di cui siparlerà più diffusamente in seguito.

  11. Presence of elevated non-HDL among patients with T2DM with CV events despite of optimal LDL-C - A report from South India.

    Science.gov (United States)

    Kumpatla, Satyavani; Soni, Anju; Narasingan, S N; Viswanathan, Vijay

    2016-01-01

    Elevated non-high density lipoprotein cholesterol (non-HDL-C) was the commonest lipid abnormality among T2DM patients with cardiovascular events (CV) events. Prevalence of elevated non-HDL-C was 21.6% among patients who were on statin therapy and with optimal low density lipoprotein-cholesterol (LDL-C) levels. Despite an optimal LDL-C level, 47% of the T2DM patients with CV events had elevated non-HDL-C.

  12. Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk

    DEFF Research Database (Denmark)

    Nordestgaard, Børge G; Tybjærg-Hansen, Anne

    2011-01-01

    To evaluate whether new and known genetic determinants of plasma levels of LDL cholesterol, lipoprotein(a), triglyceride-rich lipoproteins, and HDL cholesterol associate with the risk of cardiovascular disease expected from the effect on lipoprotein levels. Concordance or discordance of such gene...... genetic determinants with cardiovascular disease risk will either favor or disfavor that these lipoproteins are causally related to cardiovascular disease.......To evaluate whether new and known genetic determinants of plasma levels of LDL cholesterol, lipoprotein(a), triglyceride-rich lipoproteins, and HDL cholesterol associate with the risk of cardiovascular disease expected from the effect on lipoprotein levels. Concordance or discordance of such...

  13. Correlation Between Obesity and High Density Lipoprotein Cholesterol (HDL-C) in Breast Cancer Patients of Southern Rajasthan

    OpenAIRE

    Inamdar, Padmanabh; Mehta, Garima

    2011-01-01

    Despite advances in management of breast cancer, etiology is still elusive. Diet, obesity and other life style factors have been implicated in its etiology. We assessed the role of obesity and HDL-C levels in patients with rural background in etiology of breast cancer. To know the relation between obesity and incidence of breast cancer in local population. Also to know serum HDL-C level in breast cancer and its correlation with breast cancer. A nested pilot study of 50 breast cancer patients ...

  14. Effect of sterol carrier protein-2 gene ablation on HDL-mediated cholesterol efflux from cultured primary mouse hepatocytes

    OpenAIRE

    Storey, Stephen M.; Atshaves, Barbara P.; McIntosh, Avery L.; Kerstin K. Landrock; Martin, Gregory G.; Huang, Huan; Ross Payne, H.; Johnson, Jeffery D.; Macfarlane, Ronald D.; Kier, Ann B.; Schroeder, Friedhelm

    2010-01-01

    Although HDL-mediated cholesterol transport to the liver is well studied, cholesterol efflux from hepatocytes back to HDL is less well understood. Real-time imaging of efflux of 22-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-amino)-23,24-bisnor-5-cholen-3β-ol (NBD-cholesterol), which is poorly esterified, and [3H]cholesterol, which is extensively esterified, from cultured primary hepatocytes of wild-type and sterol carrier protein-2 (SCP-2) gene-ablated mice showed that 1) NBD-cholesterol efflux w...

  15. Impact of Nursery Seeding Density, Nitrogen, and Seedling Age on Yield and Yield Attributes of Fine Rice Impacto de la Densidad de Siembra en Vivero, Nitrógeno, y Edad de Plántula sobre Rendimiento y Atributos de Rendimiento de Arroz Fino

    Directory of Open Access Journals (Sweden)

    Naeem Sarwar

    2011-09-01

    diferentes densidades de siembra (alta y baja y condiciones de N (con y sin en el cultivo del arroz temporadas 2008 y 2009. Independiente de la densidad de siembra y la aplicación de fertilizantes, plántulas de vivero de 10-d presentaron mayores rendimientos y componentes de rendimiento (tallos productivos, altura de planta, peso de 1000 granos, y rendimiento de paja, mientras que en etapas posteriores se observó una interacción significativa con el manejo de vivero. El trasplante de plántulas fértiles de 20 d cultivadas con baja densidad de siembra en la cama del vivero, se tradujo en un mayor número de macollos productivos m-2 (233,3; 227,3, producción de paja (11,1; 10,7 t ha-1, y rendimiento final (3,6; 3,4 t ha-1, en los años 2008 y 2009 respectivamente. Los atributos de rendimiento y el rendimiento se redujeron significativamente después del trasplante plántulas mayores cultivadas con alta densidad de siembra y sin fertilizante en vivero. Producción de macollos (165,7; 133, rendimiento de paja (8,7; 8,1 t ha-1 y rendimiento de arroz (2,0; 1,8 t ha-1 mínimos se registraron con trasplante de plántulas mayores de 40 d cultivadas con alta de densidad de siembra y sin aplicación de N. Estos hallazgos sustentan el uso de plántulas jóvenes en un sistema de intensificación de arroz e ilustran que con una pequeña inversión adicional en el cultivo de plántulas sanas y vigorosas en la cama de semillas del vivero, los agricultores pueden aumentar los rendimientos.

  16. The Triglyceride to HDL Ratio and Its Relationship to Insulin Resistance in Pre- and Postpubertal Children: Observation from the Wausau SCHOOL Project

    Directory of Open Access Journals (Sweden)

    Karen Olson

    2012-01-01

    Full Text Available Insulin resistance (IR is a risk factor for ischemic heart disease and diabetes and raises the triglyceride/high-density lipoprotein (TG/HDL ratio in adults, but is not well defined in children. Purpose. To investigate the TG/HDL ratios in children as an IR marker. Methods. Wausau SCHOOL Project assessed 99 prepubertal and 118 postpubertal children. The TG/HDL ratio was correlated with numerous risk factors. Results. TG/HDL ratio was significantly correlated with QUICKI, HOMA-IR, zBMI, waist-to hip ratio, systolic and diastolic BP, LDL size and LDL number. A group of 32 IR children (HOMA-IR > 1 SD from the mean, i.e., >2.45 had significantly higher TG/HDL (3.11 ± 1.77 compared to non-IR children (1.86 ± 0.75. A TG/HDL ratio of ≥2.0 identified 32 of the 40 children deemed IR by HOMA-IR (>2.45 with a sensitivity of 0.80 and a specificity of 0.66. Children with TG/HDL ratio ≥3 were heavier and had higher BP, glucose, HOMA-IR, LDL number, and lower HDL level, QUICKI, and LDL size, regardless of pubertal status. Conclusion. The TG/HDL ratio is strongly associated with IR in children, and with higher BMI, waist hip ratio, BP, and more athrogenic lipid profile.

  17. Estudio de las propiedades antiaterogénicas de las HDL de ratones transgénicos de apoA-II humana

    OpenAIRE

    Ribas Serra, Vicent

    2005-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada Las apolipoproteínas más abundantes de HDL son la apoA-I y la apoA-II. La concentración plasmática de apoA-I está inversamente relacionada con el riesgo de enfermedad coronaria y su papel en las HDL es bien conocido. La apoA-I tiene un papel estructural muy importante en HDL, interacciona con receptores de HDL provocando el eflujo de colesterol de membranas celulares y es cofactor de la LCAT. En cambio, el papel que jueg...

  18. Folded Functional Lipid-Poor Apolipoprotein A-I Obtained by Heating of High-Density Lipoproteins: Relevance to HDL Biogenesis

    OpenAIRE

    Jayaraman, Shobini; Cavigiolio, Giorgio; Gursky, Olga

    2012-01-01

    High-density lipoproteins (HDL) remove cell cholesterol and protect from atherosclerosis. The major HDL protein is apolipoprotein A-I (apoA-I). Most plasma apoA-I circulates in lipoproteins, yet ~5% forms monomeric lipid-poor/free species. This metabolically active species is a primary cholesterol acceptor and is central to HDL biogenesis. Structural properties of lipid-poor apoA-I are unclear due to difficulties in isolating this transient species. We used thermal denaturation of human HDL t...

  19. Basic density and pulp yield relationship with some chemical parameters in eucalyptus trees Densidade e rendimento em polpa celulósica e sua relação com alguns parâmetros químicos no eucalipto

    Directory of Open Access Journals (Sweden)

    Ana Maria Loureiro da Seca

    2006-12-01

    /guaiacilo (S/G e seringaldeído/vanilina (S/V. As amostras dos quartis de alta densidade e as de baixo rendimento foram semelhantes, ambas com baixos valores de S/V (3,99-4,09 e S/G (3,88-4,12 e os mais elevados teores de fenóis totais (13,3-14,3 g de ácido gálico por quilograma. As madeiras do quarto quartil de rendimento são estatisticamente distintas das outras, com as maiores razões S/G (5,15 e S/V (4,98 e os menores teores de fenóis totais (8,7 g de ácido gálico por quilograma. Os parâmetros grupos metoxílicos e açúcares totais são os mais adequados para a diferenciação das amostras provenientes do primeiro quartil de densidade.

  20. Correlação linear e espacial entre produtividade de Brachiaria brizantha, densidade do solo e porosidade total em função do sistema de manejo do solo Linear and spatial correlations among forage yield, bulk density and total porosity in function of soil management system

    Directory of Open Access Journals (Sweden)

    Edney L. da Vitória

    2012-10-01

    Full Text Available A densidade e a porosidade são propriedades físicas do solo que são alteradas em função do sistema de manejo utilizado, com consequente influência sobre a produtividade das culturas. A produtividade da planta forrageira, Brachiaria brizantha, em função da densidade do solo e da porosidade total foi analisada em dois sistemas de manejo de solo, em experimento conduzido no segundo semestre de 2009, no município de Santa Teresa, no Estado do Espírito Santo. O objetivo foi estudar a variabilidade e as correlações lineares e espaciais entre os atributos da planta e do solo, visando a selecionar um indicador da qualidade física do solo de boa representatividade para produtividade de forragem. Marcaram-se duas parcelas de 40 m por 50 m a cada 5 m, em duas direções, resultando em um reticulado retangular de 99 pontos, em cada um dos sistemas utilizados: preparo convencional e plantio direto. Os atributos estudados, além de não terem variado aleatoriamente, apresentaram variabilidade dos dados entre média e alta, e seguiram padrões espaciais bem definidos, com alcance entre 20,3 e 24,2 m. Por sua vez, a correlação linear entre o atributo da planta e os do solo, em função do elevado número de observações, foi baixa. A melhor correlação para produtividade de matéria seca foi com a densidade do solo na profundidade de 0,0 - 0,15 m, independentemente do sistema de manejo do solo, indicando que a produtividade e a densidade do solo são inversamente proporcionais. Portanto, a densidade do solo avaliada na camada de 0,0 - 0,15 m apresentou-se como satisfatório indicador da qualidade física do solo, quando se considerou a produtividade da forrageira.Total porosity and bulk density are strongly affected by soil management, which reflects directly in agricultural productivity. The productivity of the forage, Brachiaria brizantha, in function of bulk density and total porosity was analyzed in two soil management systems, in an

  1. Audiitor kaebas Alta Capitali arve pärast Läti kohtusse / Henrik Ilves

    Index Scriptorium Estoniae

    Ilves, Henrik

    2008-01-01

    Eesti Päevalehe andmetel kaebas rahvusvaheline audiitorfirma Ernst & Young Lätis kohtusse investeerimisfirma Alta Capital, kuna firma ei ole maksnud esitatud arvet. Nõude suuruseks on 4,69 miljonit krooni

  2. Caracterización morfométrica de la cuenca alta del arroyo Las Lajas, Córdoba: Un análisis estadístico

    Directory of Open Access Journals (Sweden)

    N. Doffo

    2005-03-01

    Full Text Available En base a un análisis estadístico de los principales parámetros morfomé tricos, se hace una caracterización hidrológica de la cuenca alta del arroyo Las Lajas. En particular se discute la influencia de la estructura y litología sobre el diseño de la red de drenaje. La cuenca alta del arroyo Las Lajas drena una superficie aproximada de 41 km² y se desarrolla sobre un basamento plutónico-metamórfico del Precámbrico-Paleozoico superior. El relieve está conformado por serranías bajas, valles de fondo plano, con relleno aluvial y coluvial. La precipitación media anual es de 860 mm. La forma de la cuenca está parcialmente controlada por la Falla Las Lajas. Los parámetros morfométricos utilizados son: densidad de drenaje, frecuencia de cursos de primer orden, rugosidad de la cuenca, relación de bifurcación, relación de longitudes y relación de elongación. Estos se aplicaron a subcuencas de tercer orden, agrupadas en un sector oriental y otro occidental, delimitados por la Falla Las Lajas. De cada parámetro medido se obtuvieron estadísticos de posición y de dispersión y se realizaron, previa prueba de normalidad y de correlación, tests estadísticos, análisis de agrupamiento y factorial. El resultado no demuestra que exista un control litológico sobre el diseño de la red de drenaje. Un análisis de agrupamiento sobre las subcuencas indica una división en dos conjuntos que no muestran una relación obvia con la estructura ni la litología del sustrato.

  3. Neuromielitis óptica con alta expresión de acuaporina-4 y anticuerpos anti-acuaporina-4 positivos en suero

    Directory of Open Access Journals (Sweden)

    Alejandra Báez

    2012-04-01

    Full Text Available La presencia de anticuerpos IgG en suero, con blanco en los canales de acuaporina-4, es específica de la neuromielitis óptica (NMO. El 60% de los pacientes con NMO presentan lesiones cerebrales en la resonancia magnética (RM; en un 8% (mayoría niños estas lesiones se consideraron "atípicas". Presentamos dos pacientes con NMO y lesiones en el SNC de alta expresión de acuaporina-4. Caso 1: varón de 50 años, que comenzó con pérdida de visión en ojo derecho (OD. Recibió tratamiento empírico con metilprednisolona 1 g/d x 3 días. Al mes presentó dolor generalizado y hemiparesia derecha; nuevamente recibió metilprednisolona 1 g/d x 5 días e IgG IV 400 mg/kg/d × 5 días. Recuperó la deambulación persistiendo el dolor y fenómenos paroxísticos en los 4 miembros. Potenciales evocados visuales: P100, ojo izquierdo (OI 123 mseg. OD sin respuesta. La RM de cerebro (FLAIR mostró hiperintensidad en nervio óptico derecho, hipotálamo y comisura blanca anterior. RM cervical: lesión medular extensa (5 cuerpos vertebrales. Caso 2: mujer de 53 años, con disminución de la agudeza visual en ambos ojos y parestesias en miembros inferiores que remitieron espontáneamente. Evolucionó al mes con cuadriparesia e incontinencia esfinteriana. Recibió metilprednisolona 1 g/d x 5 días, sin mejoría. Potenciales evocados visuales: P100 OI 124 mseg. OD 128 mseg. RM cerebro: (FLAIR hiperintensidad hipotalámica y periacueductal. RM cervical: lesión medular extensa (7 cuerpos vertebrales. Anticuerpos anti-acuaporina-4 positivos en ambos pacientes (inmunofluorescencia indirecta. Las lesiones consideradas "atípicas", como aquí, en sitios con alta densidad de proteínas canales de agua AQP4 deberán considerarse para el diagnóstico diferencial.

  4. Efeitos da atividade física na densidade mineral óssea e na remodelação do tecido ósseo Efectos de la actividad física en la densidad mineral ósea y en la remodelacion del tejido óseo Effects of the physical activity on the bone mineral density and bone remodelation

    Directory of Open Access Journals (Sweden)

    Eduardo Lusa Cadore

    2005-12-01

    Full Text Available Este artigo revisa os efeitos de diferentes modalidades esportivas e do treinamento de força na remodelação óssea e discutir as possíveis relações da densidade mineral óssea (DMO com a força muscular e a composição corporal. Numerosos estudos indicam que a atividade física de alto impacto, ou que exija alta produção de força, pode ter um efeito benéfico na DMO, devido à deformação desse tecido, ocorrida durante a atividade. Alguns autores têm avaliado os efeitos do treinamento físico em alguns marcadores bioquímicos da remodelação óssea, já que a variação das concentrações desses marcadores pode indicar um estado de formação ou reabsorção óssea. Entretanto, a inconsistência dos resultados encontrados sugere que a análise dos efeitos da atividade física na remodelação óssea, através desses marcadores, deve ser mais investigada. Existem muitas discrepâncias a respeito da relação entre a DMO com a força muscular e a composição corporal, principalmente na determinação de qual desses fatores está mais associado com a DMO. A determinação de qual o tipo de atividade física seja ideal para aumentar o pico de massa óssea na adolescência, ou mesmo mantê-la após a idade adulta, é muito importante para a prevenção e o possível tratamento da osteoporose.Este artículo busca revisar los efectos de modalidades deportivas diferentes y del entrenamiento de fuerza en la remodelación del hueso y discutir las posibles relaciones entre la densidad mineral del hueso (DMO con la fuerza muscular y la composición corporal. Los numerosos estudios indican que la actividad física de alto impacto o que exige producción alta de fuerza, pueden tener un efecto beneficioso en la DMO, debido a la deformación que ese tejido, pasa durante la actividad física. Algunos autores han estado evaluando los efectos de la educación física en algunos marcadores bioquímicos de la remodelación del hueso, desde la variaci

  5. Importância da HDL-c para a ocorrência de doença cardiovascular no idoso La importancia del HDL-c para la ocurrencia de la enfermedad cardiovascular en el adulto mayor Importance of HDL-c for the occurrence of cardiovascular disease in the elderly

    Directory of Open Access Journals (Sweden)

    Elizabete Viana de Freitas

    2009-09-01

    Full Text Available FUNDAMENTO: Estudos sobre o impacto da HDL-c e ocorrência de doença cardiovascular (CV em idosos são escassos. OBJETIVO: Avaliar as variáveis clínicas e laboratoriais e a ocorrência de eventos CV em idosos estratificados de acordo com o comportamento da HDL-c em seguimento de oito anos. MÉTODOS: Foram avaliados, em dois momentos (A1 e A2, com espaço mínimo de cinco anos, 81 idosos, com idade média de 68,51 ± 6,32 (38,2% do sexo masculino. Os indivíduos foram divididos em 3 grupos de acordo com o nível da HDL-c: HDL-c normal nas duas avaliações (GN (n=31; HDL-c baixa nas duas avaliações (GB (n=21; e HDL-c variável de A1 para A2 (GV (n=29. Foram registrados os eventos CV maiores: doença coronariana (angina, infarto miocárdio, revascularização miocárdica percutânea/cirúrgica, acidente vascular encefálico, acidente isquêmico transitório, doença carotídea, demência e insuficiência cardíaca. RESULTADOS: Os grupos não diferiram quanto à idade e sexo em A1 e A2. As médias dos triglicérides foram menores no GN em A1 (p=0,027 e A2 (p=0,016 que no GB. Já a distribuição de eventos CV foi de 13 eventos no GN (41,9%, 16 (76,2% no GB e de 12 (41,4% no GV (χ2=7,149, p=0,024. Em análise de regressão logística observou-se que quanto maior a idade (OR=1,187, p=0,0230 e quanto menor a HDL-c (OR=0,9372, p=0,0102, maior a ocorrência de eventos CV. CONCLUSÃO: O HDL-c permanentemente baixo ao longo de oito anos de acompanhamento foi fator de risco para desenvolvimento de eventos CV em idosos.FUNDAMENTO: Estudios sobre el impacto del HDL-c y ocurrencia de enfermedad cardiovascular (CV en adultos mayores son raros. OBJETIVO: Evaluar las variables clínicas y laboratoriales y la ocurrencia de eventos CV en adultos mayores estratificados según el comportamiento del HDL-c en seguimiento de ocho años. MÉTODOS: Se evaluaron, en dos momentos (A1 y A2, con espacio mínimo de cinco años, a 81 adultos mayores, con edad promedio de

  6. Transporte de juvenis de curimbatá Prochilodus lineatus em diferentes densidades - doi: 10.4025/actascianimsci.v32i2.8415 Transportation of curimbata Prochilodus lineatus juveniles in different densities - doi: 10.4025/actascianimsci.v32i2.8415

    Directory of Open Access Journals (Sweden)

    João Batista Kochenborger Fernandes

    2010-07-01

    Full Text Available Neste estudo foi avaliado o efeito do transporte de curimbatá Prochilodus lineatus, em três densidades (100, 150 e 250 g L-1, sobre a sobrevivência e variáveis metabólicas, iônicas e hematológicas (série vermelha. Juvenis de curimbatá foram transportados em sacos plásticos durante 6h e amostrados antes da embalagem, imediatamente após a chegada, 24 e 96h após o transporte. Os peixes transportados na densidade mais alta apresentaram maior mortalidade durante o período de recuperação. As variáveis físico-químicas da água: condutividade e amônia total apresentaram maiores valores quanto maior a densidade (p -1 induziu maior mortalidade e os piores valores nas variáveis avaliadas. O período de 96h de recuperação após evento estressante foi suficiente para o retorno aos valores basais das variáveis hematológicas, mas não foi suficiente para as metabólicas e iônicas. aThis study evaluated the effects of curimbata Prochilodus lineatus transportation in three densities (100, 150 and 250 g L-1 on survival, metabolic, ionic and hematological (red series variables. Curimbata juveniles were transported in plastic bag during six hours, and sampled before packing, immediately after the arrival, 24 and 96 hours after transportation. During recovery, higher mortality was seen in fish transported in the highest density. Water variables, such as conductivity and total ammonia, presented increased values as density increased (p -1 density induced the highest mortality rate and the worst variables values measured. 96 hours of recovery after the stressing event was enough to return to initial values for hematological variables, but was not sufficient to return to initial values for metabolic and ionic variables.

  7. Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study

    Directory of Open Access Journals (Sweden)

    Medel Octavio

    2004-07-01

    Full Text Available Abstract Background Hypertriglyceridemia in combination with low HDL cholesterol levels is a risk factor for cardiovascular disease. Our objective was to evaluate the efficacy of ciprofibrate for the treatment of this form of dyslipidemia and to identify factors associated with better treatment response. Methods Multicenter, international, open-label study. Four hundred and thirty seven patients were included. The plasma lipid levels at inclusion were fasting triglyceride concentrations between 1.6–3.9 mM/l and HDL cholesterol ≤ 1.05 mM/l for women and ≤ 0.9 mM/l for men. The LDL cholesterol was below 4.2 mM/l. All patients received ciprofibrate 100 mg/d. Efficacy and safety parameters were assessed at baseline and at the end of the treatment. The primary efficacy parameter of the study was percentage change in triglycerides from baseline. Results After 4 months, plasma triglyceride concentrations were decreased by 44% (p 2 compared to the rest of the population (8.2 vs 19.7%, p Conclusions Ciprofibrate is efficacious for the correction of hypertriglyceridemia / low HDL cholesterol. A greater decrease in non-HDL cholesterol was found among cases with excess body weight. The mechanism of action of ciprofibrate may be influenced by the pathophysiology of the disorder being treated.

  8. Demografia e densidade de perfilhos de capim-braquiária sob pastejo em lotação intermitente

    Directory of Open Access Journals (Sweden)

    Jorge Nunes Portela

    2011-03-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos de intensidades de pastejo e de frequências de desfolha na demografia e densidade de perfilhos de capim-braquiária (Urochloa decumbens syn. Brachiaria decumbens sob lotação intermitente. Foram avaliados duas intensidades de pastejo (5 e 10 cm de altura pós-pastejo e duas frequências de desfolha (período de descanso até que o dossel atingisse 95 e 100% de interceptação luminosa, IL, de agosto de 2007 a agosto de 2008. Utilizou-se o delineamento inteiramente casualizado, em arranjo fatorial com quatro repetições. Avaliaram-se as densidades populacionais e as taxas de aparecimento e sobrevivência de perfilhos basais (DPPb, TAPb e TSPb, respectivamente e aéreos+basais (DPPab, TAPab e TSPab. As maiores TAPb e TAPab, no outono, foram obtidas nos pastos desfolhados a 10 cm. Porém, no final da primavera e no verão, a intensidade de 5 cm resultou em maiores taxas, que promoveram maior DPPb. No verão, a TSPb foi maior para pastos manejados à intensidade de 10 cm. O manejo da pastagem que resulta em maiores DPPab, TAPab e TSPab, durante as épocas de rápido crescimento dos pastos, é o de 10 cm de intensidade de pastejo e 95% de IL de frequência de desfolha.

  9. Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades

    Science.gov (United States)

    Cirigliano, D.; Vial, J. C.; Rovira, M.

    A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

  10. Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe

    NARCIS (Netherlands)

    M.L. Bots (Michiel); D.E. Grobbee (Diederick); P.C. Elwood; Y. Nikitin; J.T. Salonen; A. Freire de Concalves; D. Inzitari; J. Sivenius; V. Benetou (Vassiliki); J. Tuomilehto; P.J. Koudstaal (Peter Jan)

    2002-01-01

    textabstractBACKGROUND: Controversy remains on the relation between serum lipids levels and stroke risk. This paper investigated the association of total and HDL cholesterol level to fatal and non-fatal, and haemorrhagic and ischaemic stroke in four European cohorts participating i

  11. De HDL-cholesterolbepaling en de veranderingen in het lipoproteinpatroon bij de rat onder verschillende dieet-omstandigheden

    NARCIS (Netherlands)

    Janssen GB; van Leeuwen FXR; Speijers GJA

    1988-01-01

    Doel van het onderzoek was het ontwikkelen van een snelle betrouwbare micro-HDL-cholesterolbepaling in serum van de rat die toepasbaar was onder verschillende dieet omstandigheden. Drie groepen van 10 mannelijke Wistar ratten (RIV-Tox) kregen respectievelijk een semisynthetisch dieet (SSP-TOX), een

  12. Ethnic differences in total and HDL cholesterol among Turkish, Moroccan and Dutch ethnic groups living in Amsterdam, the Netherlands

    NARCIS (Netherlands)

    J.K. Ujcic-Voortman; G. Bos; C.A. Baan; D.G. Uitenbroek; A.P. Verhoeff; J.C. Seidell

    2011-01-01

    Background High total cholesterol and low HDL (high-density lipoprotein) cholesterol are important determinants of cardiovascular disease. Little is known about dyslipidemia among Turkish and Moroccan migrants, two of the largest ethnic minority groups in several European countries. This study exami

  13. Flow-mediated vasodilation is not impaired when HDL-cholesterol is lowered by substituting carbohydrates for monounsaturated fat

    NARCIS (Netherlands)

    de Roos, NM; Bots, ML; Siebelink, E; Katan, MB

    2001-01-01

    Low-fat diets, in which carbohydrates replace some of the fat, decrease serum cholesterol. This decrease is due to decreases in LDL-cholesterol but in part to possibly harmful decreases in HDL-cholesterol. High-oil diets, in which oils rich in monounsaturated fat replace some of the saturated fat, d

  14. A Single In-Vial Dual Extraction Strategy for the Simultaneous Lipidomics and Proteomics Analysis of HDL and LDL Fractions.

    Science.gov (United States)

    Godzien, Joanna; Ciborowski, Michal; Armitage, Emily Grace; Jorge, Inmaculada; Camafeita, Emilio; Burillo, Elena; Martín-Ventura, Jose Luis; Rupérez, Francisco J; Vázquez, Jesús; Barbas, Coral

    2016-06-01

    A single in-vial dual extraction (IVDE) procedure for the subsequent analysis of lipids and proteins in the high-density lipoprotein (HDL) and low-density lipoprotein (LDL) fractions derived from the same biological sample is presented. On the basis of methyl-tert-butyl ether (MTBE) extraction, IVDE leads to the formation of three phases: a protein pellet at the bottom, an aqueous phase with polar compounds, and an ether phase with lipophilic compounds. After sample extraction, performed within a high-performance liquid chromatography vial insert, the ether phase was directly injected for lipid fingerprinting, while the protein pellet, after evaporation of the remaining sample, was used for proteomics analysis. Human HDL and LDL isolates were used to test the suitability of the IVDE methodology for lipid and protein analysis from a single sample in terms of data quality and matching composition to that of HDL and LDL. Subsequently, HDL and LDL fractions isolated from ApoE-KO and wild-type mice were used to validate the capacity of IVDE for revealing changes in lipid and protein abundance. Results indicate that IVDE can be successfully used for the subsequent analysis of lipids and proteins with the advantages of time saving, simplicity, and reduced sample amount. PMID:27117984

  15. Cholesterol/HDL-c ratio lowering effect of green tea in rats exposed to depot medroxiprogesterone acetate

    Directory of Open Access Journals (Sweden)

    Elly Susilawati

    2015-09-01

    Conclusion: Green tea extract inhibits the increase in LDL-c and cholesterol/HDL-c ratio induced by DMPA. This may provide a natural therapeutic alternative for normalizing the lipid profile found in subjects exposed to DMPA. [J Exp Integr Med 2015; 5(3.000: 165-167

  16. Trans fatty acids, HDL-cholesterol, and cardiovascular disease risk - Effects of dietary changes on vascular reactivity

    NARCIS (Netherlands)

    Roos, de N.M.

    2001-01-01

    Intake of trans fatty acids increases the risk of coronary heart disease, even more so than saturated fatty acids. We wanted to investigate whether this higher risk was caused by the decrease in serum HDL-cholesterol by trans fatty acids. To do this, we studied th

  17. Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk

    DEFF Research Database (Denmark)

    Nordestgaard, Børge G; Tybjærg-Hansen, Anne

    2011-01-01

    To evaluate whether new and known genetic determinants of plasma levels of LDL cholesterol, lipoprotein(a), triglyceride-rich lipoproteins, and HDL cholesterol associate with the risk of cardiovascular disease expected from the effect on lipoprotein levels. Concordance or discordance...

  18. Produção do milho híbrido 30F35HR cultivado na savana de Roraima em diferentes densidades de plantio.

    OpenAIRE

    Valle, Ítalo César Aguiar; Alves, José Maria Arcanjo; Silva, Luana dos Santos; Uchôa, Sandra Cátia Pereira; Albuquerque, José de Anchieta Alves de; Silva, Deyse Cristina Oliveira da

    2013-01-01

    A densidade de plantas pode maximizar o potencial produtivo de variedades de milho melhoradas, uma vez que, em geral, estas apresentam porte mais baixo e arquitetura foliar mais ereta. Objetivou-se com esse trabalho avaliar o efeito de três densidades de plantios nos componentes de produção do milho transgênico híbrido Pioneer 30F35HR cultivado na savana de Roraima. O experimento foi conduzido na área experimental do Centro de Ciências Agrárias da Universidade Federal de Roraima, no Campus do...

  19. Influencia de tres densidades de siembra y cuatro niveles de fertilización en la variedad de maíz INIA 612-Maselba

    OpenAIRE

    Walker Cubas Pérez; Christian Córdova Díaz

    2013-01-01

    El experimento se realizó el año 2008, en el Campo Experimental San Miguel de la EEA. San Roque del INIA - Loreto, con el objetivo de determinar el efecto de diferentes densidades de siembra y niveles de fertilización nitrogenada en el rendimiento de grano de la variedad de maíz amarillo duro, INIA 612 – MASELBA; en condiciones de suelos aluviales de restinga inundable. Se evaluaron tres densidades de siembra, 0,80m x 0,50m con 2 plantas por sitio (50 000 plantas/ha), 0,8m x 0,60m con 3 plant...

  20. Densidades de plantio e doses de biofertilizante na produção de capim-limão Density and biofertilizer levels for lemon grass production

    OpenAIRE

    Blank, Arie F.; Maria de Fátima Arrigoni-Blank; Verônica F Amancio; Marcelo da C Mendonça; Luiz G M de Santana Filho

    2007-01-01

    O objetivo do trabalho foi avaliar o efeito de densidades de plantio e doses de biofertilizante comercial na produção de capim-limão (Cymbopogon citratus (D.C.) Stapf). O experimento foi implantado em parcelas subdivididas com três repetições, colocando-se nas parcelas as densidades de plantio (33.333, 49.382, 55.555 e 111.111 plantas ha-1) e nas subparcelas as doses de biofertilizante (0; 20; 40 e 60 t ha-1). Foram realizadas nove colheitas em intervalos de 42 dias. Avaliou-se a sobrevivênci...

  1. Lipid lowering and HDL raising gene transfer increase endothelial progenitor cells, enhance myocardial vascularity, and improve diastolic function.

    Directory of Open Access Journals (Sweden)

    Stephanie C Gordts

    Full Text Available BACKGROUND: Hypercholesterolemia and low high density lipoprotein (HDL cholesterol contribute to coronary heart disease but little is known about their direct effects on myocardial function. Low HDL and raised non-HDL cholesterol levels carried increased risk for heart failure development in the Framingham study, independent of any association with myocardial infarction. The objective of this study was to test the hypothesis that increased endothelial progenitor cell (EPC number and function after lipid lowering or HDL raising gene transfer in C57BL/6 low density lipoprotein receptor deficient (LDLr(-/- mice may be associated with an enhanced relative vascularity in the myocardium and an improved cardiac function. METHODOLOGY/PRINCIPAL FINDINGS: Lipid lowering and HDL raising gene transfer were performed using the E1E3E4-deleted LDLr expressing adenoviral vector AdLDLr and the human apolipoprotein A-I expressing vector AdA-I, respectively. AdLDLr transfer in C57BL/6 LDLr(-/- mice resulted in a 2.0-fold (p<0.05 increase of the circulating number of EPCs and in an improvement of EPC function as assessed by ex vivo EPC migration and EPC adhesion. Capillary density and relative vascularity in the myocardium were 28% (p<0.01 and 22% (p<0.05 higher, respectively, in AdLDLr mice compared to control mice. The peak rate of isovolumetric relaxation was increased by 12% (p<0.05 and the time constant of isovolumetric relaxation was decreased by 14% (p<0.05 after AdLDLr transfer. Similarly, HDL raising gene transfer increased EPC number and function and raised both capillary density and relative vascularity in the myocardium by 24% (p<0.05. The peak rate of isovolumetric relaxation was increased by 16% (p<0.05 in AdA-I mice compared to control mice. CONCLUSIONS/SIGNIFICANCE: Both lipid lowering and HDL raising gene transfer have beneficial effects on EPC biology, relative myocardial vascularity, and diastolic function. These findings raise concerns over the

  2. Comparação das frações HDL e LDL colesterol como fatores de risco para a aterosclerose carotídea Comparative study of HDL and LDL cholesterol as risk factors for carotid atherosclerosis

    Directory of Open Access Journals (Sweden)

    Rubens José Gagliardi

    1995-12-01

    Full Text Available Estudo prospectivo com o objetivo de verificar qual das frações do colesterol sanguíneo, HDL ou LDL, é mais significativa para o desenvolvimento da aterosclerose das artérias carótidas (AC. Constou de 125 indivíduos de ambos os sexos, com idade entre 45 a 75 anos, incluídos aleatoriamente. Em todos foi procedida a dosagem sanguínea do colesterol total e das frações HDL e LDL e estudo ultrassonográfico (através de ultrassonografia modo B das AC. Os resultados mostraram que a presença de placa de ateroma, com ou sem estenose nas AC, é inversamente proporcional aos níveis de HDL. Estes achados foram estatisticamente significantes (x2=6,57 e x2=9,24, respectivamente para placa sem estenose e com estenose; x2 crítico = 5,99 para α=5% . Foi também constatada associação entre a presença de placa aterosclerótica na AC e níveis sangüíneos elevados de LDL: quanto maiores os níveis de LDL, maior a proporção de indivíduos com placas, porém este achado não foi estatisticamente significante (x2=0,97, x2 crítico 5,99 para α =5%. Não foi encontrada nesta casuística relação entre níveis elevados de LDL e presença de estenose nas AC. Estes resultados, ainda que iniciais, sugerem que níveis baixos de HDL são mais aterogênicos para as AC comparativamente a níveis elevados de LDL.In order to find out whether there exists a relationship between HDL and LDL serum levels and atherosclerotic plaques in the carotid artery (CA, a prospective study was carried out involving 125 patients. They were aleatorily included, of both sexes and age between 45-75 years old. HDL and LDL serum levels were measured as well CA ultrasonographic mode B investigated. It was verified that the number of patients having atherosclerotic plaques in CA was inversely proportional to the HDL levels. We came up with the same ratio when the HDL levels were compared to the number of patients having CA stenosis. These results were statistically signifcant (x

  3. CHANGES OF HDL-C AND LDL-C OF DIABETIC RATS AND REGULATORY EFFECTS OF SERICIN%糖尿病大鼠HDL-C和LDL-C的变化及丝胶的调节作用

    Institute of Scientific and Technical Information of China (English)

    杨振军; 张艳; 侯丽娜; 刘东慧; 陈志宏

    2013-01-01

    目的:探讨丝胶对2型糖尿病大鼠低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)的调节作用。方法:48只雄性SD大鼠随机分为正常对照组、糖尿病模型组、丝胶治疗组和阳性对照组,每组12只大鼠。25mg/kg链脲佐菌素腹腔注射3d(1次/d)建立2型糖尿病大鼠模型;模型成功建立后,糖尿病模型组大鼠不再做任何处理,丝胶治疗组大鼠给予丝胶(2.4g/kg/d)灌胃35d,阳性对照组大鼠给予二甲双胍(55.3mg/kg/d)灌胃35d。分别检测各组大鼠的血糖以及血清HLD-C和LDL-C的水平。结果:与正常对照组大鼠比较,模型组大鼠的血糖、LDL-C明显升高,HDL-C明显降低(P<0.01,P<0.05);与模型组大鼠比较,丝胶治疗组、阳性对照组大鼠的血糖、LDL-C明显降低,HDL-C明显升高(P<0.01)。结论:丝胶可通过提高HDL-C水平、降低LDL-C水平改善糖尿病时血脂代谢紊乱。%Objective:To investigate the regulatory effects of sericin on low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) of type 2 diabetic rats.Methods:48 male SD rats were randomly divided into normal control group, diabetes model group, sericin treatment group and positive control group (n=12). Streptozotocin (25mg/kg) was injected into the peritoneal cavity for 3 days (one time a day) to establish type 2 diabetes rats model. Then the rats in model group received no more treatments;the rats in sericin treatment group were lavaged sericin (2.4g/kg/d) for 35-day;the rats in positive control group were lavaged metformin (55.3mg/kg/d) for 35-day. The blood glucose, HDL-C and LDL-C of rats in each group were respectively detected.Results:Compared with rats in normal control group, the blood glucose and LDL-C of rats in model group increased obviously, while HDL-C decreased obviously (P<0.01,P<0.05). Compared

  4. Comparison between Gradient Gel Electrophoresis and Nuclear Magnetic Resonance Spectroscopy in Estimating Coronary Heart Disease Risk Associated with LDL and HDL Particle Size

    NARCIS (Netherlands)

    B.J. Arsenault; I. Lemieux; J.P. Després; N.J. Wareham; E.S.G. Stroes; J.J.P. Kastelein; K.T. Khaw; S.M. Boekholdt

    2010-01-01

    BACKGROUND: Gradient gel electrophoresis (GGE) and nuclear magnetic resonance (NMR) spectroscopy are both widely accepted methods for measuring LDL and HDL particle size. However, whether or not GGE- or NMR-measured LDL or HDL particle size predicts coronary heart disease (CHD) risk to a similar ext

  5. Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice

    NARCIS (Netherlands)

    Hoorn, J.W.A. van der; Haan, W. de; Berbée, J.P.P.; Havekes, L.M.; Jukema, J.W.; Rensen, P.C.; Princen, H.M.G.

    2008-01-01

    Objective - Niacin potently decreases plasma triglycerides and LDL-cholesterol. In addition, niacin is the most potent HDL-cholesterol- increasing drug used in the clinic. In the present study, we aimed at elucidation of the mechanism underlying its HDL-raising effect. Methods and Results - InAPOE*3

  6. Niche conservatism of Eulophia alta, a trans-Atlantic orchid species

    Directory of Open Access Journals (Sweden)

    Marta Kolanowska

    2014-03-01

    Full Text Available The genus Eulophia embraces over 230 species distributed through the tropical and subtropical Africa, Asia, Australia and the Americas. In Neotropics it is represented by a sole species – E. alta. The aim of the presented study was to evaluate the difference between ecological niches occupied by American and African populations of this species based on the ecological niche modeling. The similarity between the glacial and present niches occupied by E. alta was calculated and the factors limiting the species occurrence were identified. Areas of seasonal tropical forest, tropical savanna and woodland served as refugia for the studied species during last glacial maximum and they were more widespread in Neotropics than in Africa. No significant niche shift after last glacial maximum was observed. The distribution of E. alta in its whole range is restricted mainly by temperature seasonality. The differences in the niches occupied by African and Neotropical populations of E. alta suggest preglacial disjunction of the species range and independent adaptation of both groups. Despite the significant range disjunction of E. alta the species is characterized by relatively high degree of niche conservatism.

  7. Reflexões acerca das nanotecnologias e as novas densidades técnicas-científicas-informacionais na agricultura

    Directory of Open Access Journals (Sweden)

    Soraia de Fátima Ramos

    2009-01-01

    Full Text Available As pesquisas sobre os potenciais usos das nanotecnologias no agronegócio suscitam enormes dúvidas sobre os reais benefícios ou malefícios em relação à adoção desta inovação. Daí a preocupação desta investigação em incluir as ciências humanas nos debates sobre a difusão das nanotecnologias. Pressupõe-se que, dada a efetiva incorporação dos novos produtos e processos nanotecnológicos, irá se configurar um aprofundamento das densidades técnicas-científicas- informacionais no espaço agrário brasileiro.

  8. Reflexões acerca das nanotecnologias e as novas densidades técnicas-científicas-informacionais na agricultura

    OpenAIRE

    Soraia de Fátima Ramos; Roberto Martins; Richard Domingues Dulley; Roberto de Assumpção; Elizabeth Alves e Nogueira; Sebastião Nogueira Junior; Marisa Zeferino Barbosa; André Luiz de Souza Lacerda

    2009-01-01

    As pesquisas sobre os potenciais usos das nanotecnologias no agronegócio suscitam enormes dúvidas sobre os reais benefícios ou malefícios em relação à adoção desta inovação. Daí a preocupação desta investigação em incluir as ciências humanas nos debates sobre a difusão das nanotecnologias. Pressupõe-se que, dada a efetiva incorporação dos novos produtos e processos nanotecnológicos, irá se configurar um aprofundamento das densidades técnicas-científicas- informacionais no espaço agrário brasi...

  9. Força muscular e densidade mineral óssea em idosos eutróficos e desnutridos

    OpenAIRE

    Karla Helena Coelho Vilaça; Eduardo Ferriolli; Nereida Kilza da Costa Lima; Francisco José Albuquerque de Paula; Julio Sérgio Marchini; Julio Cesar Moriguti

    2011-01-01

    OBJETIVO: Este estudo teve como objetivo avaliar a associação do estado nutricional com a força muscular de preensão manual e a densidade mineral óssea em idosos do sexo masculino. MÉTODOS: Participaram do estudo 41 idosos do sexo masculino, sendo 20 eutróficos (peso: M=69,6, DP=8,4; índice de massa corporal: M=25,7, DP=2,2) e 21 desnutridos (peso: M=50,9, DP=6,1; índice de massa corporal: M=18,7, DP=1,8), classificados subjetivamente segundo a Mini Avaliação Nutricional. A avaliação antropom...

  10. EVALUACIÓN DE DENSIDADES DE PLANTACIÓN EN EL CULTIVO DE LA JAMAICA (Hibiscus sabdariffa L.)

    OpenAIRE

    Z. Terán; F. De Soto(Departamento de Sistemas Físicos, Químicos y Naturales, Universidad Pablo de Olavide, 41013 Sevilla, Spain)

    2004-01-01

    La investigación se llevó a cabo en el Instituto Nacional de Ciencias Agrícolas (INCA), en el verano del 2001, con el objetivo de comparar seis distancias de plantación en el cultivo de la Jamaica ( Hibiscus sabdariffa L.) y su influencia en los rendimientos y sus componentes por superficie para definir la densidad óptima. Las distancias empleadas fueron: 1.20x1.00m; 1.20x0.90m; 1.00x1.00m; 1.00x0.90m; 0.90x0.90m y 0.90x0.80m; a esos marcos de plantación correspondieron las siguientes densida...

  11. Densidad del Mono aullador Alouatta seniculus (Linnaeus, 1766 Mammalia: primates en el arroyo coloso, Departamento de Sucre, Colombia

    Directory of Open Access Journals (Sweden)

    Fajardo Patiño Alirio

    1996-12-01

    Full Text Available Nueve manadas de Alouatta seniculus, fueron estudiadas a lo largo de tres meses y medio, entre Mayo y Agosto de 1983. Se tomaron en cuenta aspectos relativos al estado y densidad poblacional en el Arroyo Colosó, Departamento de Sucre. Se establece una relación de los datos obtenidos y procesados en este trabajo con los suministrados por otros autores en estudios similares con la misma especie y en diferentes lugares.Nine troops of Alouatta seniculus, were studied for a period of three and half months betwen May and August of 1983. Relevant facts of the condition and population density in the Colosó stream, located in Sucre Deparment, were taken. A relation is stablished among the facts obtained and processed in this investigation with facts provided by another authors in similar studies with the same specie in different locations.

  12. El funcional de densidad local: una aplicacion a problemas de física de la materia condensada

    OpenAIRE

    Takeuchi, Noboru

    2012-01-01

    Se presenta una breve introducción al funcional de densidad local. Esta teoría permite la simplificación de las ecuaciones matemáticas que describen la estructura electrónica de los átomos, moléculas y sólidos. Durante muchos años se han buscado métodos que permitan el entendimiento de cómo funcionan los enlaces entre átomos. Con el nacimiento de la mecánica cuántica a principios de los años 1900 se sentaron las bases, formulando las leyes que rigen el comportamiento a nivel atómico. Sin emba...

  13. Densidade do solo, atributos químicos e sistema radicular do milho afetados pelo pastejo e manejo do solo

    Directory of Open Access Journals (Sweden)

    V. R. Silva

    2000-03-01

    Full Text Available A integração lavoura-pecuária é uma alternativa de renda dos produtores no sul do Brasil. Entretanto, o pisoteio animal e, ou, o preparo de solo podem compactá-lo, prejudicando o crescimento radicular e a produtividade das plantas. Estudaram-se os efeitos do pisoteio animal em regime de pastejo contínuo durante o inverno/primavera e do impacto do plantio direto e do preparo convencional de solo no estado de compactação, atributos químicos e distribuição radicular. Em Podzólico Vermelho-Amarelo de textura superficial franca, foi implantada uma pastagem de estação fria composta por aveia (Avena strigosa Schreb e azevém (Lolium multiflorum L.. A carga animal variou conforme o crescimento da pastagem. Em dezembro de 1996, foi implantada a cultura do milho (Zea mays L. para a produção de silagem, usando os seguintes tratamentos: plantio direto na área não pastejada, plantio direto após o pastejo, preparo convencional de solo na área não pastejada e preparo convencional de solo após pastejo. As avaliações apresentadas neste estudo são referentes ao terceiro ano de cultivo, no qual houve um período de pastejo de 107 dias. Aos 45 dias da emergência do milho, foram abertas trincheiras (100 x 40 cm para visualizar a distribuição do sistema radicular e coletar amostras de solo, a cada 5 cm, para caracterização química e determinação da densidade do solo e de raízes. Ao longo do perfil (0-40 cm, o desenho da distribuição de raízes indicou maior quantidade de raízes no preparo convencional de solo, concordando com os resultados de densidade de raízes. O pisoteio animal não teve efeito sobre as características físicas, possivelmente pelo fato de o resíduo da pastagem permanecer próximo a 1,0 Mg ha-1 de matéria seca. A densidade do solo no plantio direto, na camada de 5-10 cm, foi de 1,41 Mg m-3, tanto na área pastejada como na não pastejada. No preparo convencional de solo, esses valores foram de 1,15 Mg m-3

  14. Rentabilidade da cultura da macieira cultivar Gala em duas densidades de plantio Investment return for Gala apple cultivar using two planting densities

    Directory of Open Access Journals (Sweden)

    Carlos Leomar Kreuz

    2002-03-01

    Full Text Available O presente trabalho discute, com base em um estudo de caso, a viabilidade econômica de ampliar a densidade de plantio de macieiras cultivar Gala de 1.000 plantas por hectare para 3.378 plantas por hectare. Os resultados mostraram que a taxa interna de retorno não variou (próxima de 1,61% ao mês, independentemente da densidade utilizada, o que sugere o uso da menor densidade de plantio, uma vez que esta requer um menor volume de recursos financeiros. O custo unitário de produção também se mantém praticamente o mesmo ao se variar a densidade de plantio.The present study was carried out to analyse economic performances of Gala apple orchards at different planting densities. Two orchard densities (1,000 and 3,378 plants/ha were evaluated in an orchard near Fraiburgo, SC, Brazil. The use of both planting densities resulted in the same internal rate of return (approximately 1.6% a month. It is suggested to use a lower planting system, once it requires less capital. Unit cost also remained the same for both planting densities used in this study.

  15. ENFERMEDADES Y COMPONENTES DE RENDIMIENTO EN LÍNEAS DE FRÉJOL BAJO TRES DENSIDADES DE SIEMBRA

    Directory of Open Access Journals (Sweden)

    Felipe Rafael Garc\\u00E9s-Fiallos

    2014-01-01

    Full Text Available El objetivo fue evaluar las enfermedades, el rendimiento y sus componen - tes en líneas de fréjol bajo tres distanciamientos de siembra. El trabajo se realizó durante la época seca del año 2011, en la Universidad Técnica Estatal de Quevedo (UTEQ, Quevedo, Ecuador. Se determinó la incidencia y severidad de la roya ( Uromyces appendiculatus y mustia hilachosa ( Rizoctonia solani en los estadíos R7 (formación en legumbres y R8 (llenado de legumbres, y después de la cosecha la incidencia de las pudriciones radiculares ( Macrophomina phaseolina y R. solani . Los componentes de rendimiento (número de nudos, legumbres, granos, granos por legumbre, legumbres estériles y granos por planta y peso de granos. Se empleó un Diseño de Bloques Completos al Azar (DBCA con doce tratamientos y tres repeticiones, con arreglo factorial de 4 (líneas promisorias x 3 (planta/m. Para la comparación entre las medias de los tratamientos se empleó la prueba de Tukey al 5% de probabilidad del error. Las líneas promisorias de fréjol EVG 06-103 y SER-03 presentaron menor intensidad de enfermedades. Un aumento en la densidad poblacional causó un acrecentamiento en la intensidad de la roya. Las líneas SER-08 y SER-03 obtuvieron la mayor productividad según la mayoría de componentes de rendimiento y peso de granos. Finalmente, el incremento de la densidad de plantas promovió reducción significativa en el número de legumbres, granos y granos por legumbre por planta, contrario al aumento observado en el peso de granos

  16. Influencias de la densidad y podas sobre la producción de Pinus taeda L. a los 7 años de edad.

    Directory of Open Access Journals (Sweden)

    Rubén Costas

    2010-08-01

    Full Text Available En un ensayo con 3 niveles de densidad y 12 tratamientos de poda, se evaluaron los efectos de la densidad, la altura de poda, el número de levantes de poda y la interacción entre la densidad y las podas sobre la producción de la masa de Pinus taeda L. a los 7 años de edad. Las variables evaluadas fueron el diámetro a la altura de pecho medio (DAP, la altura media, el volumen individual, el volumen por unidad de superficie, el área basal, el diámetro máximo sobre muñón (DMSM, el coeficiente de forma de Girard (CFG, el diámetro de ramas (DRBC y el ángulo de inserción de las ramas (ARBC en la base de la copa. En los tratamientos con mayor densidad de plantación se observaron mayores volúmenes por unidad de superficie, área basal y CFG que en los tratamientos con menor densidad. Estos produjeron mayores DAP, volúmenes individuales, DMSM, DRBC y ARBC que los tratamientos con mayores densidades. Los tratamientos con menores alturas finales de poda produjeron mayores DAP, volúmenes individuales, área basal y volúmenes por unidad de superficie que los tratamientos con mayores alturas de poda. Los menores DMSM se obtuvieron con alturas finales de poda de 3,30 m y 4,40 m realizadas a los 4 años de edad y los mayores DMSM ocurrieron al no efectuarse podas a los 5 años hasta 5,50 m y 6,60 m. No se encontraron diferencias significativas entre los valores medios de DRBC, ARBC y CFG producidos por los 12 tratamientos de poda. La interacción entre densidad y los tratamientos de poda no fue significativa para ninguna de las variables respuestas.

  17. Variabilidade Espacial e Densidade Amostral da Suscetibilidade Magnética e dos Atributos de Argissolos da Região de Manicoré, AM

    Directory of Open Access Journals (Sweden)

    Ivanildo Amorim de Oliveira

    2015-06-01

    Full Text Available A dificuldade em encontrar informações recentes sobre o comportamento espacial dos atributos dos solos na Região Amazônica tem sido preocupação de muitos pesquisadores. Em razão da grande dificuldade e dos custos para avaliar os atributos dos solos, têm-se utilizados métodos alternativos para predição de atributos do solo como a suscetibilidade magnética. Sendo assim, o objetivo deste trabalho foi avaliar a variabilidade espacial da suscetibilidade magnética (SM, os atributos físicos e químicos e determinar a densidade amostral de coleta em Argissolo Vermelho sob floresta nativa, Terra Preta Arqueológica (TPA sob cultivo, e pastagem na região de Manicoré, Amazonas. Nessas áreas, foram estabelecidas malhas com dimensão de 70 × 70 m e demarcados pontos nessas malhas, espaçados a cada 10 m, totalizando 64 pontos. Esses pontos foram georreferenciados e, em seguida, realizaram-se as coletas de solo em cada ponto da malha nas camadas de 0,00-0,20 e 0,40-0,60 m para determinar atributos químicos (pH em água, matéria orgânica, P, K, Ca, Mg e acidez potencial, físicos (textura, macroporosidade, microporosidade, diâmetro médio ponderado, densidade do solo e densidade de partículas e suscetibilidade magnética. Os dados foram submetidos à análise de variância, e as médias, comparadas pelo teste de Tukey a 5 %. Realizou-se a estatística descritiva. Para caracterizar a variabilidade, fez-se a geoestatística com uso de semivariograma escalonado. O alcance dos semivariogramas escalonados foi utilizado para determinar a densidade amostral mínima de coleta para estimar a variabilidade dos atributos estudados. As áreas de TPA e pastagem apresentaram maior variabilidade, apresentando menor alcance e maior densidade amostral (cinco pontos por hectare. A SM apresentou comportamento espacial similar aos atributos físicos e químicos estudados, sendo a densidade amostral da SM próxima à densidade amostral dos atributos nos

  18. Novel mutations of ABCA1 transporter in patients with Tangier disease and familial HDL deficiency.

    Science.gov (United States)

    Fasano, Tommaso; Zanoni, Paolo; Rabacchi, Claudio; Pisciotta, Livia; Favari, Elda; Adorni, Maria Pia; Deegan, Patrick B; Park, Adrian; Hlaing, Thinn; Feher, Michael D; Jones, Ben; Uzak, Asli Subasioglu; Kardas, Fatih; Dardis, Andrea; Sechi, Annalisa; Bembi, Bruno; Minuz, Pietro; Bertolini, Stefano; Bernini, Franco; Calandra, Sebastiano

    2012-11-01

    The objective of the study was the characterization of ABCA1 gene mutations in 10 patients with extremely low HDL-cholesterol. Five patients (aged 6 months to 76 years) presented with splenomegaly and thrombocytopenia suggesting the diagnosis of Tangier disease (TD). Three of them were homozygous for novel mutations either in intron (c.4465-34A>G) or in exons (c.4376delT and c.5449C>T), predicted to encode truncated proteins. One patient was compound heterozygous for a nucleotide insertion (c.1758_1759insG), resulting in a truncated protein and for a nucleotide substitution c.4799A>G, resulting in a missense mutation (p.H1600R). The last TD patient, found to be heterozygous for a known mutation (p.D1009Y), had a complete defect in ABCA1-mediated cholesterol efflux in fibroblasts, suggesting the presence of a second undetected mutant allele. Among the other patients, four were asymptomatic, but one, with multiple risk factors, had severe peripheral artery disease. Three of these patients were heterozygous for known mutations (p.R130K+p.N1800H, p.R1068C, p.N1800H), while two were carriers of novel mutations (c.1195-27G>A and c.396_397insA), predicted to encode truncated proteins. The pathogenic effect of the two intronic mutations (c. 1195-27G>A and c.4465-34A>G) was demonstrated by the analysis of the transcripts of splicing reporter mutant minigenes expressed in COS-1 cells. Both mutations activated an intronic acceptor splice site which resulted in a partial intron retention in mature mRNA with the production of truncated proteins. This study confirms the allelic heterogeneity of TD and suggests that the diagnosis of TD must be considered in patients with an unexplained splenomegaly, associated with thrombocytopenia and hypocholesterolemia. PMID:22959828

  19. DOSES DE NITROGÊNIO E DENSIDADES DE PLANTAS COM E SEM UM REGULADOR DE CRESCIMENTO AFETANDO O TRIGO, CULTIVAR OR-1 NITROGEN DOSES AND PLANT DENSITIES WITH AND WITHOUT A GROWTH REGULATOR AFFECTING WHEAT, CULTIVAR OR-1

    Directory of Open Access Journals (Sweden)

    Jeferson Zagonel

    2002-02-01

    Full Text Available Doses de nitrogênio e elevadas populações de plantas são utilizadas visando a obtenção de altas produtividades em trigo. Porém, estes fatores podem promover o acamamento das plantas, especialmente para as cultivares de porte médio ou alto. O uso de produtos que reduzem a estatura das plantas pode minimizar este problema. Visando avaliar o efeito do regulador de crescimento trinexapc-ethyl em diferentes populações de plantas e doses de nitrogênio, na cultivar de trigo OR-1, instalou-se um experimento na Fazenda Escola "Capão da Onça", da Universidade Estadual de Ponta Grossa, em Ponta Grossa, PR, no ano de 1999. O delineamento experimental foi blocos ao acaso em esquema fatorial 2 x 3 x 4, em quatro repetições. Os vinte e quatro tratamentos constaram da aplicação de 125 g i.a./ha de trinexapac-ethyl e testemunha; densidades de 55, 75 e 112 plantas/m no espaçamento de 0,17m entre fileiras e doses de 0, 45, 90 e 135kg/ha de nitrogênio em cobertura. A aplicação do trinexapac-ethyl resultou em plantas com entre-nós mais curtos; em aumento do número de espigas/m e da produtividade. Com o aumento da dose de nitrogênio, ocorreu aumento da estatura das plantas, do número de espigas/m e da produtividade. Com o aumento da densidade de plantas, o diâmetro do caule, a massa seca das plantas e o número de grãos por espiga diminuíram mas o número de espigas/m e o peso de mil grãos aumentaram, sem afetarem a produtividade. Não ocorreu acamamento em nenhum dos tratamentos.Elevated nitrogen rates and high plant populations are adopted with the purpose of achieving high wheat yields. However, these factors may promote the lodging of the plants, especially for the medium and tall height cultivars. The utilization of products which reduce plant height could minimize this problem. With the aim of evaluating the effects of a growth regulator on different plant populations and nitrogen rates for the wheat cultivar OR-1, an experiment was

  20. Evaluation of alcohol outlet density and its relation with violence Avaliação da densidade de pontos de vendas de álcool e sua relação com a violência

    Directory of Open Access Journals (Sweden)

    Ronaldo Laranjeira

    2002-08-01

    , buscou-se investigar a disponibilidade de bebidas alcoólicas em uma região densamente povoada e melhorar o entendimento sobre o acesso a essa substância, para que ações preventivas futuras possam beneficiar-se dessas informações. MÉTODOS: O estudo foi realizado em uma região do Município de São Paulo, SP, Brazil. Foram treinados 24 entrevistadores, moradores da região, para fazerem a coleta de dados. Foi selecionada uma área de 19 ruas, cobrindo uma distância de 3.7 km. Foi feito um perfil de cada ponto de venda de bebidas alcoólicas dessa região. RESULTADOS: Foram registrados 107 pontos de venda de álcool. O número de outras propriedades nessa região foi de 1.202. Duas medidas de densidade de pontos de venda podem ser calculadas: número de pontos de venda por kilômetro de rua (29 pontos/km e proporção de todas as propriedades de venda de álcool (1 em 12. CONCLUSÕES: Comparado a estudos internacionais principalmente de países desenvolvidos, a área estudada tem a mais alta densidade de pontos de vendas de álcool registrada na literatura médica. As informações sobre as vendas de álcool e os locais de venda contribuíram para melhorar o entendimento do acesso ao álcool na região estudada. Ações preventivas futuras poderão beneficiar-se dessas informações.

  1. The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.

    Directory of Open Access Journals (Sweden)

    Elisabeth M van Leeuwen

    Full Text Available Genome-wide association studies (GWAS have revealed 74 single nucleotide polymorphisms (SNPs associated with high-density lipoprotein cholesterol (HDL blood levels. This study is, to our knowledge, the first genome-wide interaction study (GWIS to identify SNP×SNP interactions associated with HDL levels. We performed a GWIS in the Rotterdam Study (RS cohort I (RS-I using the GLIDE tool which leverages the massively parallel computing power of Graphics Processing Units (GPUs to perform linear regression on all genome-wide pairs of SNPs. By performing a meta-analysis together with Rotterdam Study cohorts II and III (RS-II and RS-III, we were able to filter 181 interaction terms with a p-value<1 · 10-8 that replicated in the two independent cohorts. We were not able to replicate any of these interaction term in the AGES, ARIC, CHS, ERF, FHS and NFBC-66 cohorts (Ntotal = 30,011 when adjusting for multiple testing. Our GWIS resulted in the consistent finding of a possible interaction between rs774801 in ARMC8 (ENSG00000114098 and rs12442098 in SPATA8 (ENSG00000185594 being associated with HDL levels. However, p-values do not reach the preset Bonferroni correction of the p-values. Our study suggest that even for highly genetically determined traits such as HDL the sample sizes needed to detect SNP×SNP interactions are large and the 2-step filtering approaches do not yield a solution. Here we present our analysis plan and our reservations concerning GWIS.

  2. Triglyceride/HDL ratio as a screening tool for predicting success at reducing anti-diabetic medications following weight loss.

    Directory of Open Access Journals (Sweden)

    Ghanshyam Palamaner Subash Shantha

    Full Text Available BACKGROUND AND OBJECTIVES: Intentional weight loss, by reducing insulin resistance, results in both better glycemic control and decreased need for anti-diabetic medications. However, not everyone who is successful with weight loss is able to reduce anti-diabetic medication use. In this retrospective cohort study, we assessed the predictive accuracy of baseline triglyceride (TGL/HDL ratio, a marker of insulin resistance, to screen patients for success in reducing anti-diabetic medication use with weight loss. METHODS: Case records of 121 overweight and obese attendees at two outpatient weight management centers were analyzed. The weight loss intervention consisted of a calorie-restricted diet (~1000Kcal/day deficit, a behavior modification plan, and a plan for increasing physical activity. RESULTS: Mean period of follow-up was 12.5 ± 3.5 months. By study exit, mean weight loss and mean HbA1c% reduction were 15.4 ± 5.5 kgs and 0.5 ± 0.2% respectively. 81 (67% in the study cohort achieved at least 1 dose reduction of any anti-diabetic medication. Tests for predictive accuracy of baseline TGL/HDL ratio ≤ 3 to determine success with dose reductions of anti-diabetic medications showed a sensitivity, specificity, positive predictive value, negative predictive value, area under the curve, likelihood ratio (LR + and LR-of 81, 83, 90, 70, 78, 4.8 and 0.2, respectively. Reproducibility of TGL/HDL ratio was acceptable. CONCLUSION: TGL/HDL ratio shows promise as an effective screening tool to determine success with dose reductions of anti-diabetic medications. The results of our study may inform the conduct of a systematic review using data from prior weight loss trials.

  3. Consumo energético de sistemas de computación de altas prestaciones

    OpenAIRE

    Balladini, Javier; Morán, Marina; Rozas, Claudia; De Giusti, Armando Eduardo; Suppi, Remo; Rexachs del Rosario, Dolores; Luque, Emilio

    2015-01-01

    En la última década, el consumo energético ha dirigido el diseño de todos los sistemas de cómputo, desde dispositivos móviles a los cuales cada vez se le piden más prestaciones que deben ser soportadas por una pequeña batería, hasta los sistemas de Cómputo de Altas Prestaciones (HPC, de High Performance Computing), objeto de nuestro interés, los cuales consumen enormes cantidades de energía. Esta alta demanda energ ética tiene serias consecuencias financieras, medioambientales, y en muchos c...

  4. Neurociências, altas habilidades e implicações no currículo

    OpenAIRE

    Amauri Betini Bartoszeck

    2014-01-01

    http://dx.doi.org/10.5902/1984686X14284O presente estudo inicialmente define e descreve as sub-disciplinas que compõem as neurociências com potenciais aplicações educacionais para crianças e adultos  identificados com altas habilidades. Objetiva-se com uma breve introdução morfofuncional ao sistema nervoso que serve de pano de fundo para auxiliar o entendimento da ponte teórico-experimental da relação de neurociências e altas habilidades. São salientados aspectos da base evolucionista e bioló...

  5. Computación de altas prestaciones: problemáticas y aplicaciones

    OpenAIRE

    Balladini, Javier; Morán, Marina; Rozas, Claudia; Frati, Fernando Emmanuel; De Giusti, Armando Eduardo; Suppi, Remo; Rexachs del Rosario, Dolores; Luque, Emilio

    2016-01-01

    Nuestra investigación está centrada en dos lí- neas. Por un lado, el estudio del consumo energé- tico de los sistemas de Cómputo de Altas Prestaciones (HPC, de High Performance Computing) cuya alta demanda energética tiene serias consecuencias nancieras, medioambientales, y en muchos casos también sociales. El aumento de la e ciencia energética de los sistemas de HPC no solo proviene de las nuevas arquitecturas hardware, también está involucrado el software, quien debe gestionar y con gurar ...

  6. Estudo da miscibilidade das misturas de PHB e PLA, com um PHB de alta polidispersividade

    Directory of Open Access Journals (Sweden)

    Wagner Mauricio Pachekoski

    2015-02-01

    Full Text Available Neste trabalho, foi estudada a miscibilidade de misturas de um PHB constituído de frações de alta e baixa massa molar com um PLA de alta massa molar. Os materiais extrudados foram analisados pelas técnicas de calorimetria exploratória diferencial (DSC, espectroscopia dielétrica (DE e análises dinâmico-mecânicas (DMA. A partir dos resultados observou-se o distinto comportamento cristalino das frações de PHB, assim como a miscibilidade parcial do PLA com o PHB de baixa massa molar.

  7. Estudo da miscibilidade das misturas de PHB e PLA, com um PHB de alta polidispersividade

    OpenAIRE

    Wagner Mauricio Pachekoski; Carla Dalmolin; José Augusto Marcondes Agnelli

    2015-01-01

    Neste trabalho, foi estudada a miscibilidade de misturas de um PHB constituído de frações de alta e baixa massa molar com um PLA de alta massa molar. Os materiais extrudados foram analisados pelas técnicas de calorimetria exploratória diferencial (DSC), espectroscopia dielétrica (DE) e análises dinâmico-mecânicas (DMA). A partir dos resultados observou-se o distinto comportamento cristalino das frações de PHB, assim como a miscibilidade parcial do PLA com o PHB de baixa massa molar.

  8. 50 años de alta velocidad en Japón

    OpenAIRE

    Pigem Cameselle, Ramiro

    2008-01-01

    Al inaugurar los 515 kilómetros de línea de alta velocidad entre Tokio y Osaka en octubre de 1964, Japón alcanzó un logro todavía mayor que el de impulsar su propia economía. Abrió una era del transporte completamente nueva con un innovador sistema ferroviario. Con ello prestó un innegable servicio al mundo ferroviario, desencadenando un auge global de la alta velocidad e inyectando aire fresco a una industriar que estaba en claro declive. Casi 50 años más tarde, los 210 km/h inic...

  9. ALTAS CAPACIDADES: COMPARATIVA ENTRE EL MODELO ESPAÑOL Y BRITÁNICO

    OpenAIRE

    Rodríguez-Vázquez, María

    2012-01-01

    El presente trabajo de investigación exploratoria reflexiona sobre el concepto de alumno con altas capacidades y propone una comparación legislativa entre el modelo de atención a los alumnos con altas capacidades británico y español y cómo ese modelo afecta al sistema educativo general, ya que aunque tienen puntos en común entre ambos países, pero se trata dos formas de enfocar completamente distintas. Además también pretende recoger información sobre iniciativas y proyectos que reflejen l...

  10. Altas capacidades: Proyecto educativo para el aula de Educación Primaria

    OpenAIRE

    López-Presedo, Iria Flavia

    2015-01-01

    El presente TFG tiene como principal finalidad dar una respuesta educativa, eminentemente práctica, al alumnado de altas capacidades dentro del grupo-clase. En primer lugar, se han revisado las teorías de varios autores sobre las altas capacidades, los métodos de detección e intervención con este tipo de alumnado y, finalmente, se ha elaborado un proyecto en forma de programa de enriquecimiento curricular. Este proyecto se inscribe dentro de la Teoría de las inteligencias múltiples de Gard...

  11. Altas capacidades intelectuales : investigación y propuesta desde las inteligencias múltiples

    OpenAIRE

    Pulido Vinuesa, Salomé

    2015-01-01

    El presente trabajo trata sobre las altas capacidades, investigando sobre ello acerca de su historia y evolución, los diversos tipos existentes, sus características, su identificación, su evaluación, sus metodologías, entre otros. Además, se ha realizado un resumen de cómo es tratada esta necesidad educativa por las leyes, antiguas y en vigor. De igual modo, se trata la educación inclusiva, ya que es un tema que afecta a alumnos/as con altas capacidades. El programa de intervención en rel...

  12. Effect of algal food (Chlorella vulgaris concentration and inoculation density on the competition among three planktonic Brachionidae (Rotifera: Monogononta Efecto de la concentración de algas (Chlorella vulgaris y la densidad de inoculación sobre la competencia entre tres Brachionidae (Rotifera: Monogononta planctónicos

    Directory of Open Access Journals (Sweden)

    S.S.S. Sarma

    2008-08-01

    ó con el aumento de disponibilidad del alimento en el medio, pero en los cultivos mixtos, disminuyeron con el aumento de la proporción de la especie competidora. En el nivel bajo de alimento, B. havanaensis tuvo un mayor impacto negativo sobre A. fissa en comparación con B. angularis. Sin embargo, al aumentar la densidad del alga, ambas especies de Brachionus tuvieron un impacto reducido, pero similar. Por otro lado, el crecimiento poblacional de B. havanaensis fue afectado más por A. fissa que por B. angularis en las concentraciones bajas e intermedias de alimento. Con altas concentraciones del alga, el impacto de A. fissa o B. angularis sobre el crecimiento de B. havanaensis fue semejante. Cuando fue cultivado solo, para una densidad dada de alimento, A. fissa alcanzó una mayor abundancia (4 a 6 veces que las otras dos especies. La tasa de crecimiento poblacional (r de los rotíferos se incrementó con la disponibilidad del alga. Dependiendo de la especie de rotíferos y de las condiciones del experimento, la r varió entre -0.001 a 0.34 d-1. Se concluye que el resultado de la competencia entre las especies de estudio depende de la densidad inicial de los competidores, de la concentración de alimento así como de la interacción de los dos factores.

  13. Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China

    Directory of Open Access Journals (Sweden)

    Qing-Jie Chen

    2016-02-01

    Full Text Available Elevated LDL-C/HDL-C ratio has been shown to be a marker of lipid metabolism as well as a good predictor of coronary artery disease (CAD. Thus, the aim of this study was to investigate whether the LDL-C/HDL-C ratio is useful for detecting cardiovascular disease (CVD risk factors in general healthy Uygur adults in Xinjiang. A total of 4047 Uygur subjects aged ≥35 years were selected from the Cardiovascular Risk Survey (CRS study which was carried out from October 2007 to March 2010. Anthropometric data, blood pressure, lipid profile and fasting glucose were measured in all participants. The prevalence, sensitivity, specificity and distance on the receiver operating characteristic (ROC curve of each LDL-C/HDL-C ratio were calculated. The prevalence of high LDL-C and low HDL-C cholesterol was high and positively correlated with higher LDL-C/HDL-C ratio in the Uygur population. In both men and women, we detected a slight apparent trend of high prevalence of hypertension and hypercholesterolemia with higher LDL-C/HDL-C ratio. Our study also demonstrated that the discriminatory power of the LDL-C/HDL-C ratio for CVD risk factors was slightly stronger in men than in women. Analysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or ≥two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women. The results of this study showed that a LDL-C/HDL-C ratio cut-off of 2.5 might be used as the predictive marker to detect CVD risk factors among Uygur adults in Xinjiang.

  14. LDL-C/HDL-C比值与冠脉病变程度和急性冠脉综合征的关系%The Relationship of LDL-C/HDL-C Ratio with Coronary Artery Disease Degree and Acute Coronary Syndromes

    Institute of Scientific and Technical Information of China (English)

    邓彬; 欧淑其; 郑昭芬

    2005-01-01

    目的探讨LDL-C/HDL-C比值与冠脉病变程度和急性冠脉综合征的关系.方法回顾性地分析203例选择性冠状动脉造影的病人,其中冠心病组(冠状动脉狭窄至少有1支以上≥50%)139例,非冠心病组(冠状动脉狭窄<50%)64例,分析两组间血脂各项(LDL-C、HDL-C、LDL-C/HDL-C)是否有差异性;LDL-C、HDL-C、LDL-C/HDL-C与冠状动脉狭窄程度的相关性及与急性冠脉综合征的关系.结果 (1)LDL-C、LDL-C/HDL-C冠心病组比非冠心病组高[LDL-C(2.71±0.81)mmol/L vs (2.33±0.95)mmol/L, P<0.01;LDL-C/HDL-C (2.43±0.66) vs (1.92±0.64), P<0.01];冠心病组HDL-C(1.17±0.29) mmol/L低于非冠心病组HDL-C(1.27±0.35)mmol/L,(P<0.05).(2)LDL-C,LDL-C/HDL-C与冠状动脉狭窄程度呈微弱的正相关(RldL-c=0.159,P=0.024, RldL-c/hdL-c=0.213,P=0.002) .(3)LDL-C/HDL-C急性冠脉综合征组(2.61±0.85) 比非急性冠脉综合症组(2.33±0.86)高(P<0.05),差异有显著性.结论 (1)冠心病患者LDL-C、LDL-C/HDL-C升高、HDL-C降低.(2)LDL-C,LDL-C/HDL-C与冠状动脉狭窄程度呈微弱正相关.(3) LDL-C/HDL-C比值升高是急性冠脉综合症的一项比较常见的伴有脂质异常.

  15. Effect of simvastatin on anti-oxidation and anti-inflammation properties of HDL in apoE-/-mice

    Directory of Open Access Journals (Sweden)

    Di TIAN

    2013-03-01

    Full Text Available Objectives  To investigate the effect of simvastatin on anti-oxidation and anti-inflammation properties of high density lipoprotein (HDL in apoE-/-mice fed with high-fat diet. Methods  Eighteen 8-week old male C57BL/6J mice as blank control group were fed with normal diet, and thirty 8-week old male apoE-/-mice were fed with high-fat diet. Four weeks later, 6 mice in each group were sacrificed. The remaining 24 apoE-/-mice were randomly divided into two groups (12 each: atherosclerosis group (AS group and simvastatin group, while the remaining 12 C57BL/6J mice served as control group. The mice in both control and AS group were fed with the original diet, and the mice in simvastatin group were fed with the same high-fat diet plus simvastatin 5mg/ (kg.d. At the end of the 8th and 16th week, 6 mice were sacrificed in each group. Serum lipid levels, paraoxonase 1 (PON1 activity (arylesterase activity, serum myeloperoxidase (MPO activity, high-density lipoprotein inflammation index (HII and serum hs-CRP levels were determined. The atherosclerotic lesion formation in the aorta was manifested by oil red O staining. Results  At the end of the 8th week, no difference was found in the levels of serum low density lipoprotein cholesterol (LDL-C and high density lipoprotein cholesterol (HDL-C between simvastatin and AS group. At the end of 16th week, the levels of serum LDL-C decreased significantly (P<0.01 and HDL-C increased significantly (P<0.05 in simvastatin group compared with AS group. At the end of the 8th and 16th week, a significant enhancement of the serum PON1 activity but marked decrease in MPO activity, HII, and serum hs-CRP levels were found in simvastatin group compared with that in AS group. The percentage of plaque area (surface area of plaque/ surface area of whole intima in the aorta was significantly smaller in simvastatin group than that in AS group (P<0.05 or P<0.01. Conclusions In addition to lowering LDL-C and elevating HDL

  16. Stress responses of juvenile matrinxã (Brycon amazonicus after transport in a closed system under different loading densities Respostas de estresse de matrinxã (Brycon amazonicus juvenil após transporte em sistema fechado sob diferentes densidades de carga

    Directory of Open Access Journals (Sweden)

    Janessa Sampaio de Abreu

    2008-08-01

    , a temperatura esteve em torno de 32°C, pH 6,5-6,78, a amônia total foi de 1,09-1,7mg L-1, a amônia não-ionizada foi de 3,58-9,33 x 10³mg L-1 e alcalinidade 134-165mg CaCO3 L-1. O cortisol plasmático e a glicose sanguínea aumentaram após o transporte nos peixes em todas as densidades ensaiadas, voltando aos valores controle 24h depois. Os valores de osmolaridade não mudaram logo após o transporte, mas aumentaram 24h depois de modo igual em todas as densidades. O cloreto plasmático diminuiu na chegada, de modo inversamente proporcional à densidade de carga. O hematócrito diminuiu 24h depois da chegada dos peixes, em todas as densidades testadas, mas não houve diferença no número de eritrócitos. Não houve mortalidade até uma semana após o transporte. O matrinxã mostrou ser uma espécie tolerante a altas densidades de carga em embalagens para transporte além de suportar baixos níveis de oxigênio na água.

  17. Diseño de decodificadores de altas prestaciones para código LDPC

    OpenAIRE

    Angarita Preciado, Fabian Enrique

    2013-01-01

    En esta tesis se han investigado los algoritmos de decodificación para códigos de comprobación de paridad de baja densidad (LDPC) y las arquitecturas para la implementación hardware de éstos. El trabajo realizado se centra en los algoritmos del tipo de intercambio de mensajes para códigos estructurados los cuales se incluyen en varios estándares de comunicaciones. Inicialmente se han evaluado las prestaciones de los algoritmos existentes Sum-product, Min-Sum y las principales variantes de...

  18. Relación entre paraoxonasa, otros componentes de HDL y estado inflamatorio en hemodiálisis Relation between paraoxonase activity, other HDL components and inflammatory conditions in hemodialyzed patients

    Directory of Open Access Journals (Sweden)

    Ana Inés González

    2010-12-01

    Full Text Available La enfermedad renal crónica (ERC se asocia estrechamente con un estado pro-inflamatorio, aumento de lipoproteínas ricas en triglicéridos y disminución de HDL. La HDL contiene enzimas antioxidantes asociadas como la paraoxonasa (PON, cuya actividad en ERC se encuentra disminuida. Nuestro objetivo fue evaluar la relación entre la actividad de PON, apoA1, colesterol(col-HDL y Proteína C reactiva-altamente sensible (PCR-as como marcador de inflamación en pacientes en hemodiálisis. Se estudiaron n = 42 pacientes; edad, mediana (rango = 50 (25-67 años; sexo M/F = 22/20; antigüedad de hemodiálisis = 4.4 ± 0.5 años; índice de masa corporal (IMC = 23 ± 0.5 kg/m². Se obtuvo una muestra de sangre después de 12 h de ayuno y se determinaron los parámetros clásicos del perfil lipídico, se midieron los valores de apoproteínas A1 y B, PON a través de su actividad arilesterasa y PCR-as, la cual permitió dividir a los pacientes con PCR-as ≤ 1 (bajo riesgo, rango: 0.1 a 1.0 mg/l y > 1 mg/l (moderado y alto riesgo, 1.1 a 10.7 mg/l. Los niveles de triglicéridos, col-LDL y apoB no fueron diferentes entre los grupos. Los pacientes con PCR-as > 1 presentaron menor col-HDL (40 ± 2 mg/dl y apoA1 (118 ± 4 mg/dl que los pacientes con PCR-as ≤ 1 (50 ± 4 y 133 ± 5, respectivamente; p 1: 90.5 ± 24.0 μmol/ml.min que en PCR-as ≤ 1: 105.2 ± 18.0. Consecuentemente, se obtuvieron correlaciones inversas entre apoA1 y PCR-as, r = -0.381 p = 0.013 y entre PON y PCR-as, r = -0.32, p = 0.042. Además, el aumento de PCR-as correlacionó positivamente con el IMC, r = 0.318, p = 0.042. La disminución de col-HDL, apoA1 y PON en los individuos con mayor estado inflamatorio explicaría, en parte, el aumento de riesgo cardiovascular de estos pacientes, dado los efectos antiinflamatorios de la apoA1 y antioxidantes de la PON.Advanced Chronic Renal Disease (CKD is closely associated with a pro-inflammatory condition, with an increase in triglyceride

  19. Variación de la densidad básica de la madera de Eucalyptus grandis en arboles de siete años de edad.

    Directory of Open Access Journals (Sweden)

    Arango A. Bibiana

    2001-09-01

    Full Text Available En el presente trabajo se estima la variación de la densidad básica de la madera con la altura de los árboles en clones de Eucalyptus grandis de 7 años de edad, seleccionados en plantaciones forestales de la empresa Smurfit Cartón de Colombia localizadas en los municipios de Restrepo, Pereira y Popayán, encontrándose que la densidad decrece desde la base del árbol hacia el nivel del D.A.P y luego, a partir de este aumenta hacia la copa hasta el 75% de la altura total del árbol. De igual manera se establecen correlaciones entre la densidad básica media de la madera en función de las tres zonas de estudio y los diferentes clones. Se comparan tanto las metodologías empleadas para la determinación de la densidad básica (Norma Tappi 258-om-94 y el Método del Máximo Contenido de Humedad como los diferentes tipos de muestras empleadas para la determinación de la misma (muestras tipo disco de madera y muestras de barreno. El rango de variación de la densidad básica media para las muestras tipo disco de madera fue de 0.40 a 059 g/cm3 y para las muestras de barreno fue de 0.38 a 0.55 g/cm3. Respecto a los métodos para la determinación de la densidad básica media de la madera en muestras de barreno, el método del máximo contenido de humedad mostró una subestimación de aproximadamente 3% de la misma en comparación con los valores obtenidos por el método de la balanza hidrostática.

  20. Avaliação dos efeitos da adição de sal e da densidade no transporte de tambaqui

    Directory of Open Access Journals (Sweden)

    Gomes Levy de Carvalho

    2003-01-01

    Full Text Available Os objetivos deste trabalho foram testar a eficiência do sal como redutor de estresse e verificar a melhor densidade de transporte de juvenis de tambaqui (Colossoma macropomun em caixas de plástico adaptadas. No primeiro experimento foram testadas diferentes concentrações de sal de cozinha (NaCl na água; no segundo, o transporte foi realizado por três horas em caixas de plástico de 200 L estocadas com diferentes densidades de peixe, com 8 g de sal/L de água. O cortisol plasmático dos peixes sofreu aumento significativo após o transporte no tratamento sem sal e com 2 g de sal/L de água, retornando para níveis normais após 96 horas. A glicose plasmática dos peixes sofreu aumento após o transporte em todas as concentrações de sal testadas, com exceção da com 8 g/L de água, retornando para níveis normais em 24 horas. Nos peixes transportados no segundo experimento, com 8 g de sal/L de água, não foi verificada mudança significativa no cortisol plasmático, mas a glicose aumentou significativamente em todas as densidades após o transporte, retornando para níveis normais em 24 horas. Houve mortalidade de 11% em uma das repetições da densidade de 200 kg/m³ de água. Para o transporte com 8 g de sal/L de água, a densidade máxima deve ser de 150 kg/m³ de água. Nesta densidade os parâmetros físico-químicos de qualidade de água se mantêm com características adequadas, as respostas ao estresse são mínimas e não há mortalidade.

  1. Sistema de cómputo reconfigurable de alta performance (proyecto HPRC)

    OpenAIRE

    Kunysz, Eduardo; Rapallini, José Antonio; Osio, Jorge R.

    2015-01-01

    El objetivo de este trabajo es el estudio de las nuevas tendencias en cómputo paralelo con la finalidad de mejorar el rendimiento de cálculo. Cómo una alternativa interesante para optimizar la relación costo-prestaciones, se exploran tecnologías de computadoras de alta performance reconfigurable (HPCR).

  2. 77 FR 38823 - Notice of Availability of the Alta East Wind Project Draft Environmental Impact Statement...

    Science.gov (United States)

    2012-06-29

    ... Bureau of Land Management Notice of Availability of the Alta East Wind Project Draft Environmental Impact Statement/Environmental Impact Report and Proposed California Desert Conservation Area Plan Amendment, Kern... for future wind energy generation projects. The Draft EIS/EIR/PA evaluates the potential impacts...

  3. Grounding the past : the praxis of participatory archaeology in the Mixteca Alta, Oaxaca, Mexico

    NARCIS (Netherlands)

    Geurds, Alexander

    2007-01-01

    "Grounding the Past" addresses archaeological field praxis and its role in the political present of Santiago Tilantongo and Santiago Apoala, two communities in the Mixteca Alta region of Oaxaca, Mexico. Efforts to involve local stakeholder communities in archaeology have become an important issue wo

  4. La evaluación psicopedagógica del alumnado con altas capacidades

    OpenAIRE

    Grau Rubio, Claudia

    2012-01-01

    Se describen los instrumentos de evaluación psicopedagógica aplicables al alumnado con altas capacidades. Instrumentos referidos al alumno, al contexto escolar, a las variables socio-familiares y la determinación de las necesidades educativas especiales.

  5. 77 FR 23712 - Alta Wind VII, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Science.gov (United States)

    2012-04-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Alta Wind VII, LLC; Supplemental Notice That Initial Market-Based Rate...-referenced proceeding of Alta Wind VII, LLC's application for market-based rate authority, with...

  6. 77 FR 35669 - AltaGas Renewable Energy Colorado LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2012-06-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AltaGas Renewable Energy Colorado LLC; Supplemental Notice That Initial... notice in the above-referenced proceeding of AltaGas Renewable Energy Colorado LLC application for...

  7. 76 FR 3881 - Application To Export Electric Energy; TransAlta Energy Marketing (U.S.) Inc.

    Science.gov (United States)

    2011-01-21

    ... Application To Export Electric Energy; TransAlta Energy Marketing (U.S.) Inc. AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: TransAlta Energy Marketing (U... Office) 202-586-5260. SUPPLEMENTARY INFORMATION: Exports of electricity from the United States to...

  8. Low incidence of paradoxical reductions in HDL-C levels in dyslipidemic patients treated with fenofibrate alone or in combination with ezetimibe or ezetimibe/simvastatin

    Directory of Open Access Journals (Sweden)

    Farnier Michel

    2011-11-01

    Full Text Available Abstract Background Fibrates have been reported to cause paradoxical decreases in HDL-C in certain patients. Design and methods This post-hoc analysis explored the frequency/magnitude of HDL-C reductions in a pooled database of mixed dyslipidemic patients (LDL-C:3.4-5.7 mmol/L;TG:1.7-5.7 mmol/L receiving placebo (PBO, fenofibrate (FENO, ezetimibe plus FENO (EZE+FENO, or EZE/simvastatin plus FENO (EZE/SIMVA+FENO for 12 weeks. Results PBO-treated patients had the highest incidence of HDL-C reductions from baseline (45% compared with patients taking FENO (14%, EZE+FENO (9%, or EZE/SIMVA+FENO (9%. Reductions Conclusions The incidence of paradoxical HDL-C reductions was low in mixed dyslipidemic patients receiving FENO alone or combined with EZE or EZE/SIMVA. Trial registrations Clinicaltrials.gov: NCT00092560 and NCT00092573

  9. Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS study.

    Directory of Open Access Journals (Sweden)

    Yining Qian

    Full Text Available BACKGROUND: Intracranial atherosclerotic stenosis (ICAS is an important cause of ischemic stroke worldwide. The role of high-density lipoprotein cholesterol (HDL-C or low-density lipoprotein cholesterol (LDL-C in the development of ICAS remains to be elucidated. In the current study, we investigated the relationship of HDL-C level and the risk of developing ICAS in Chinese patients with acute ischemic stroke. METHODS: From October 2007 to June 2009, a total of 1,984 consecutive ischemic stroke patients were evaluated for the presence of symptomatic ICAS by magnetic resonance angiography (MRA. Patients were classified into two groups: intracranial steno-occlusion (ICAS group, n = 888 and non-intracranial stenosis (NICAS group, n = 1096. Serum lipid profiles were analyzed and compared between the ICAS and NICAS group. RESULTS: Significantly more patients in ICAS group had low HDL-C level (51.6% than in the NICAS group (42.9%, P<0.001. The observed association remained significant after adjustment for conventional risk factors [(adjusted OR 1.36; 95%CI (1.13-1.63]. Such predictive value of low level HDL-C persisted even when LDL-C was at very low level(<1.8 mmol/L. Patients in the lowest serum HDL-C quartile (<0.96 mmol/L had the highest risk of developing ICAS [adjusted OR 1.52; 95%CI (1.17-1.98] compared to patients in the highest serum HDL-C quartile (≥ 1.32 mmol/L after adjustments for the covariates. CONCLUSIONS: Low HDL-C level is strongly associated with the development of ICAS. There was an inverse relationship between the level of HDL-C and the risk of developing ICAS.

  10. Molecular dynamics simulation of human serum paraoxonase 1 in DPPC bilayer reveals a critical role of transmembrane helix H1 for HDL association.

    Science.gov (United States)

    Patra, Mahesh Chandra; Rath, Surya Narayan; Pradhan, Sukanta Kumar; Maharana, Jitendra; De, Sachinandan

    2014-01-01

    Serum paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-bound mammalian enzyme exhibiting antiatherosclerotic activity. Despite years of research, an accurate model for the binding interaction between PON1 and HDL has not been established. However, it is reported that anchoring of PON1 to HDL is mainly governed by an N-terminal alpha helix H1 and another short helix H2. Here, we studied the molecular association of full-length human PON1 (huPON1) with a HDL-mimetic dipalmitoylphosphatidylcholine (DPPC) bilayer using homology modeling and molecular dynamics simulations. Our results indicate that H1 is the highly dynamic part of huPON1, showing clockwise rotation of up to 30° within the DPPC bilayer. However, without phospholipid molecules, H1 experiences helical distortions, illustrating an incompatible HDL-anchoring conformation. Snorkeling interactions of K3, R18, and R27 together with aromatic locks formed by Y187, Y190, W194, and W202 are highly essential for anchoring of huPON1 to HDL's surface. Molecular mechanics/Poisson-Boltzmann solvent-accessible surface area (MM/PBSA) binding free energy calculation revealed that H1 displays greater binding affinity towards lipid molecules compared with H2 and H3, suggesting that H1 is the most probable HDL-binding domain of PON1. Binding free energy decomposition showed that K3, R18, and R27 interact with polar headgroups of DPPC membrane through electrostatic interaction. Moreover, Y187, Y190, W194, and W202 interact with DPPC lipids mainly through van der Waals interaction. Taken together, these results show that the transmembrane helix H1 along with the interfacial positively charged and aromatic resides were crucial for PON1's association with HDL particle. The current study will be useful towards understanding the antiatherosclerotic and bioscavenging properties of this promiscuous enzyme. PMID:24297451

  11. Implementation of stable isotopes lipoprotein kinetic studies: effects on HDL metabolism of a Mediterranean type diet rich in MUFAs from virgin olive oil.

    OpenAIRE

    Uliaque Cugat, Katia

    2007-01-01

    The anti-atherogenic effects ascribed to a Mediterranean-type diet rich in monounsaturatedfatty acids (MUFAs) from virgin olive oil are due, partly, to an increase in, or maintenance of,plasma concentrations of high density lipoprotein (HDL) cholesterol. However, the underlyingmechanisms that may explain these concentrations are not well characterised, to-date.Apolipoprotein (apo) A-I (apoA-I) is the major HDL apo and its kinetic parameters, such asproduction rate and catabolic rate, reflect ...

  12. Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Plasma CETP and Increases Apolipoprotein AI Levels Without Improving the Cholesterol Efflux Properties of HDL

    OpenAIRE

    Wang, Yanan; Snel, Marieke; Jonker, Jacqueline T; Hammer, Sebastiaan; Lamb, Hildo J.; de Roos, Albert; Meinders, A. Edo; Pijl, Hanno; Romijn, Johannes A.; Johannes W A Smit; Jazet, Ingrid M.; Rensen, Patrick C N

    2011-01-01

    OBJECTIVE Using a mouse model for human-like lipoprotein metabolism, we observed previously that reduction of the hepatic triglyceride (TG) content resulted in a decrease in plasma cholesteryl ester transfer protein (CETP) and an increase in HDL levels. The aim of the current study was to investigate the effects of prolonged caloric restriction in obese patients with type 2 diabetes mellitus, resulting in a major reduction in hepatic TG content, on plasma CETP and HDL levels. RESEARCH DESIGN ...

  13. Rendimiento de maíz forrajero en respuesta a fertilización nitrogenada y densidad de población

    OpenAIRE

    José Antonio Cueto Wong; David Guadalupe Reta Sánchez; José Luis Barrientos Ríos; Guillermo González Cervantes; Enrique Salazar Sosa

    2006-01-01

    En este estudio se determinó el efecto de la densidad de población y dosis de fertilización nitrogenada sobre el rendimiento y eficiencia de uso de nitrógeno en maíz (Zea mays L.) forrajero durante el ciclo de verano en la Comarca Lagunera, México, mediante dos experimentos, uno en 1998 y otro en 1999. Se estudiaron tres dosis de fertilización nitrogenada (125, 250 y 375 kg ha-1) y cinco densidades de población (9.0, 12.0, 15.0, 18.0 y 21.0 plantas/m2 en 1998; y 8.5, 11.0, 13.5, 16.0 y 18.5 p...

  14. DENSIDAD DE POBLACIÓN Y FERTILIZACIÓN NITROGENADA EN LA PRODUCCIÓN DE SEMILLA HÍBRIDA DE MAÍZ

    OpenAIRE

    Francisco Cervantes-Ortíz; Jorge Covarrubias-Prieto; José Antonio Rangel-Lucio; Arturo Daniel Terrón-Ibarra; Mariano Mendoza-Elos; Ricardo Ernesto Preciado-Ortiz

    2013-01-01

    El presente estudio tuvo como objetivo determinar el efecto de la densidad de población y la fertilización nitrogenada en el rendimiento y calidad de semilla híbrida de maíz. El experimento se realizó en el Instituto de Nacional de Investigaciones Forestales, Agrícolas y Pecuarias-Campo Experimental Bajío (INIFAP-CEBAJ), en el ciclo P-V 2009. En la cruza CML 142 x CML 176, progenitor femenino del híbrido H-374C, se evaluaron tres densidades de población (60, 75 y 90 mil plantas/ha) y tres niv...

  15. Doença celíaca em tratamento: avaliação da densidade mineral óssea

    OpenAIRE

    Carvalho Cecília Noronha de Miranda; Sdepanian Vera Lucia; Morais Mauro Batista de; Fagundes Neto Ulysses

    2003-01-01

    OBJETIVO: comparar a densidade mineral óssea de crianças e adolescentes com doença celíaca em tratamento com controles sadios, e avaliar exames laboratoriais relacionados com o metabolismo do cálcio. MÉTODOS: foram estudados 30 pacientes com doença celíaca em dieta isenta de glúten, 17 crianças e 13 adolescentes, e 23 indivíduos saudáveis. Todos os pacientes e controles realizaram a densidade mineral óssea (DEXA, Lunar). Os pacientes realizaram dosagem sérica de cálcio total, cálcio ionizado,...

  16. Heliconia acuminata reproductive success is independent of local floral density O sucesso reprodutivo de Heliconia acuminata é independente da densidade floral local

    Directory of Open Access Journals (Sweden)

    Emilio M. Bruna

    2004-09-01

    Full Text Available Reproductive plants in tropical forests are patchily distributed, with some in large aggregations of reproductive consepecifics while others are relatively isolated. This variation in floral density is hypothesized to have a major effect on plant reproductive success, since individuals in higher density neighborhoods can attract more or higher quality pollinators. We experimentally tested this hypothesis with populations of the understory herb Heliconia acuminata in central Amazonia. We created replicated plots in which reproductive plant density spanned the range of naturally occurring floral neighborhood size, then measured three surrogates of plant fitness in focal plants in each array. There was no significant difference between any of the three floral neighborhood treatments in total seed production, fruit set, or the number of seeds produced per fruit. Pollinator visitation rates to plants in all treatments were extremely low, with many plants not visited at all during the observation period. This could be because H. acuminata's hummingbird pollinators are unable to find the widely scattered reproductive plants, however this hypothesis appears unlikely. Instead, natural flowering plant densities may simply be below the threshold value at which neighborhood effects become important, even in "high-density" aggregations. Nutrient limitation, selective fruit abortion, and reproduction via male rather than female function may also be playing a role. We argue the absence of neighborhood effects may be a general phenomenon in central Amazonian forests, though additional experiments with other plant-pollinator systems are needed to determine the extent to which this hypothesis is supported.Plantas reprodutivas em florestas tropicas são distribuidas em manchas, com algumas em grandes agregações coespecíficas e outras relativamente isoladas. A hipótese é que esta variação na densidade de flores em um local tem um grande efeito no sucesso

  17. LA DENSIDAD Y TAMAÑO DE PLÁNTULAS CON CEPELLÓN EN LA PRODUCCIÓN DE ESPÁRRAGO VERDE

    OpenAIRE

    Ana Mar\\u00EDa Castagnino; Karina Elizabeth D\\u00EDaz; Patricia Sastre V\\u00E1zquez; Mar\\u00EDa Bel\\u00E9n Rosini; Silvina Sasale

    2011-01-01

    Con el objetivo de determinar la influencia del tamaño de la celda utilizada para la obtención de plántulas de espárrago y la densidad o marco de plantación empleado, sobre la producción de turiones, se evaluó en invernadero tres tamaños de celda: 1) PG: grande (70 cm3), 2) PM: mediana (30 cm3) y 3) PCh: pequeña (20 cm3) y tres densidades (35 714 (D1); 23 810 (D2) y 17 857 (D3) plantas/ha). Se efectuó un trabajo en la Chacra Experimental de la Facultad de Agronomía, en Azul, provincia de Buen...

  18. Efecto de la densidad de siembra y la adición de ácido ascórbico en el cultivo de Osteoglossum bicirrhosum

    OpenAIRE

    Carolina Cuaical T.; Evelyn Vallejo V.; Hugo Franco R.; Wilmer Sanguino O.

    2015-01-01

    RESUMENObjetivo. Evaluar el efecto de la densidad de siembra y la adición de ácido ascórbico en la alimentación de alevinos de O. bicirrhosum, cultivados en jaulas. Materiales y métodos. Se incluyeron 396 alevinos y se distribuyeron en nueve tratamientos, resultado de la combinación de los niveles del factor densidad de siembra: 1pez/5 L; 1pez/10 L y 1pez/15 L y los niveles de ácido ascórbico: 0; 500 y 1000 mg/kg. Los datos obtenidos se evaluaron mediante el análisis de varianza del diseño fa...

  19. EFFECT OF HERB-MEDICINE-CAKE-SEPARATED MOXIBUSTION ON SERUM LIPOPROTEIN CONTENTS AND RATIO OF HDL-Ch AND LDL-Ch IN HYPERLIPEMIA RABBITS

    Institute of Scientific and Technical Information of China (English)

    常小荣; 严洁; 岳增辉; 易受乡; 林亚平; 曹湘平; 沈菁

    2004-01-01

    Objective: To observe the effect of herb-medicine-cake-separated moxibustion on serum lipoprotein in hyperlipemia rabbits. Methods: 55 New-Zealand rabbits were randomly divided into control group (n=13), model group (n=14), direct moxibustion group (n=14) and herb-medicine-cake-separated moxibustion (indirect moxibustion) group (n=14). Hyperlipemia model was established by feeding the animals with specialized forage (15% vitellus powder, 5% lard, 0.5% cholesterol and common forage) for 6 weeks. Moxibustion was applied to "Juque"(CV 14), "Tianshu"(ST 25), "Fenglong"(ST 40), etc., 4 moxa-cones for every acupoint, once daily and continuously for 40 days. Serum high density lipoprotein-cholesterol (HDL-Ch), low density lipoprotein-cholesterol (LDL-Ch) and total cholesterol (TCh) contents were assayed with colorimetric method. Results: Compared with control group, serum LDL-Ch content, HDL-Ch/LDL-Ch and HDL-Ch/TCh of model group were significantly higher (P<0.05~0.01), while compared with model group, LDL-Ch contents of two moxibustion groups were strikingly lower (P<0.01). No significant differences were found between two moxibustion groups in all the 4 indexes. Conclusion: Both direct and indirect moxibustion can effectively lower serum LDL-Ch, raise HDL-Ch, HDL-Ch/LDL-Ch and HDL-Ch/TCh, and regulate lipoprotein metabolism in hyperlipemia rabbits.

  20. [Comparative study of the consumption of virgin olive oil or seje on lipid profile and oxidation resistance of high density lipoprotein (HDL) of rat plasma].

    Science.gov (United States)

    Isabel Giacopini, María; Guerrero, Omaira; Moya, Manuel; Bosch, Virgilio

    2011-06-01

    We compared the effect of the consumption of seje oil (Oenocarpus bataua), with that of olive oil, on plasma lipids and susceptibility in vitro to oxidation of high density lipoprotein (HDL) in the rat. Two groups often male Sprague Dawley rats were fed ad libitum, for a lapse of eight week, with a purified diets with 10g de seje oil or olive oil/100 g of diet (GS y GO respectively). The animals were exsanguinated at the end of the experimental after a 14 hour fast. Plasma was isolated by centrifugation, and the fractions of lipoproteins were separated from the plasma by sequential ultracentrifugation. Rats of GO had a statistically significant lower in concentration of TG (p < 0.05) compared with GS group. HDL fractions in both groups were oxidatively modified by incubation with copper ions. Differences in the fractions susceptibilities to peroxidation were studied by measuring the formation of thiobarbituric acid reactive substance (TBARS) for 3 hours. HDL in GS had a statistically significant decrease in TBARS formation (p < 0.05) relative to HDL of GO. This may be explained by the lower concentration of polyunsaturated fatty acids of HDL in GS compared with HDL in GO.

  1. Densidade de plantio de palmiteiro em regime de sombreamento permanente Planting density of Euterpe edulis mart. under shading conditions

    Directory of Open Access Journals (Sweden)

    Marilene Leão Alves Bovi

    1987-01-01

    Full Text Available Estudou-se o comportamento do palmiteiro (Euterpe edulis Mart. plantado sob mata nativa raleada, em diferentes densidades de plantio, nas condições do Vale do Ribeira, SP. Avaliou-se o crescimento vegetativo das plantas pelos seguintes parâmetros: circunferência da planta a diferentes alturas, número de folhas funcionais, comprimento da quarta folha e altura da planta. Avaliou-se também a produção, através do peso, diâmetro e comprimento do palmito obtido. A maior produção de palmito por área foi alcançada nos espaçamentos 1,5 x 1,0 e 1,0 x 1,0m.A spacing experiment with the species Euterpe edulis Mart. was carried out in the rain forest of the Vale do Ribeira region in the State of São Paulo, Brazil. In order to evaluate growth, several parameters were used: plant height, number of green leaves, length of the fourth leaf and girth at 130cm high. Maximum heart of palm yield was obtained in the 1.5 x 1.0 and 1.0 x 1.0m planting density.

  2. DENSIDADES Y PROPIEDADES VOLUMÉTRICAS DE LA MEZCLA N,N-DIMETILFORMAMIDA (DMF + 1-BUTANOL A DIFERENTES TEMPERATURAS

    Directory of Open Access Journals (Sweden)

    MANUEL PÁEZ

    2013-01-01

    Full Text Available Se determinaron las densidades de la mezcla binaria de N,N-Dimetilformamida (DMF + 1-Butanol usando un densímetro de tubo vibrador DMA 5000, sobre todo el intervalo de fracciones molares en el intervalo de temperaturas de 283.15K a 313.15K y 1.011 bar. Se calcularon los volúmenes molares de exceso (V e m volúmenes molares parciales (Vi, volúmenes molares parciales a dilución infinita (V i ∞ , volúmenes molares parciales de exceso ( V i E del soluto y del solvente. Los volúmenes molares de exceso se correlacionaron usando la ecuación de Redlich-Kister. Adicionalmente, se calcularon los coeficientes viriales (bv de acuerdo a la teoría de McMillan-Mayer. Los valores obtenidos para estos parámetros fueron discutidos en términos de las interacciones presentes en solución.

  3. EFECTOS DE LA DENSIDAD DE SIEMBRA Y FERTILIZACIÓN SOBRE LA BACTERIOSIS DEL PALMITO DE PEJIBAYE (Bactris gasipaes K.

    Directory of Open Access Journals (Sweden)

    Francisco Paulo Chaimsohn

    2008-01-01

    Full Text Available Se determinó el efecto de la densidad (3.333, 5.000 y 6.666 plantas/ha, el arreglo de siembra (rectangular y triangular y el tipo de fertilización (químico, orgánico y químico-orgánico sobre la incidencia y severidad de la enfermedad conocida como "bacteriosis del palmito", causada por la bacteria Pantoea stewartii (sin. Erwinia stewartii y el hongo Fusarium sp, en el periodo de julio de 2004 a agosto de 2005, en Guápiles, Costa Rica. El porcentaje de incidencia de la enfermedad varió de 14,1 a 80,8%. En las parcelas con el arreglo triangular hubo menor porcentaje de plantas enfermas. El porcentaje de incidencia de la bacteriosis fue mayor en las cepas de las parcelas fertilizadas con abono químico, seguido de aquellas fertilizadas con abono químico-orgánico y enmienda orgánica. La enfermedad se correlacionó de forma inversa a los contenidos de Ca, Mg, Zn, K y Mn del suelo, y al contenido foliar de Mn. Por otra parte, se correlacionó de forma directa con el contenido de Al del suelo, con los contenidos foliares de B y Cu, y con el porcentaje de interceptación de la radiación solar.

  4. Baisse du HDL-cholestérol indicateur du stress oxydatif dans le diabète de type 2

    Science.gov (United States)

    Kabamba, Arsène Tshikongo; Bakari, Salvius Amuri; Longanga, Albert Otshudi; Lukumwena, Zet Kalala

    2014-01-01

    L'hypercholestérolémie est étroitement liée au stress oxydatif. Lorsqu'il y a trop de cholestérol qui circule dans le sang, il n'est pas utilisé en totalité par les cellules et il risque de s'accumuler dans les vaisseaux sanguins. Cela peut entrainer la formation des plaques d'athérosclérose qui gênent la circulation sanguine et provoquent des accidents cardiovasculaires. Le stress oxydatif apparait très tôt dans l'histoire des complications du diabète de type 2, et est lié à l'oxydation du glucose mais aussi à la peroxydation lipidique. Le cholestérol-HDL est un marqueur important du stress oxydatif par sa capacité à faciliter la métabolisation du cholestérol, sa baisse est souvent considérée comme la source de beaucoup d'inquiétudes. L'objectif est l’évaluation de la variation du taux de cholestérol-HDL, marqueur du stress oxydatif, chez les patients diabétiques de type 2 dans la population congolaise. Nous avons inclus dans cette étude prospective des cas témoins des patients diabétiques de type 2 reconnus et diagnostiqués, et des témoins non diabétiques appariés selon l’âge et le sexe. Parallèlement au bilan biologique classique, une analyse d'un des facteurs de risque du stress oxydatif a été réalisée: baisse de HDL-Cholestérol. L’âge moyen des 30 patients diabétiques (47,77±10,78 ans) était comparable à celui des 30 témoins (48,83±10,73 ans). Une baisse significative du cholestérol-HDL dans le sang était observée chez 100% des diabétiques et 50% des témoins (p=0,0000). L'augmentation du HDL cholestérol permet d’éliminer le mauvais cholestérol en excès en nettoyant les tissus et en ramenant le cholestérol vers le foie. Lors du diabète de type 2 on constate une baisse sanguine sensible du taux de HDL-cholestérol, qui est signe indicateur du stress oxydatif. PMID:25767660

  5. Pneumonia lipoídica em adultos: aspectos na tomografia computadorizada de alta resolução Lipoid pneumonia in adults: findings on high-resolution computed tomography

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    Edson Marchiori

    2007-10-01

    Full Text Available OBJETIVO: Apresentar os aspectos na tomografia computadorizada de alta resolução do tórax da pneumonia lipoídica exógena por aspiração de óleo mineral, em pacientes adultos MATERIAIS E MÉTODOS: Foram estudados oito pacientes adultos - quatro mulheres e quatro homens - com média de idade de 69,4 anos, todos usuários de óleo mineral para tratamento de constipação intestinal. Os exames foram avaliados por dois radiologistas, de forma independente RESULTADOS: Os achados tomográficos mais comuns foram as consolidações com áreas de densidade de gordura de permeio, e o padrão de pavimentação em mosaico. As lesões foram bilaterais em seis pacientes, e unilaterais em dois CONCLUSÃO: O encontro de consolidações pulmonares com áreas de densidade de gordura de permeio, associado à história clínica do uso de óleo mineral, é diagnóstico de pneumonia lipoídica exógena.OBJECTIVE: The present study was aimed at describing the findings on high-resolution computed tomography in patients with exogenous lipoid pneumonia secondary to mineral oil aspiration MATERIALS AND METHODS: Eight adult patients - four men and four women - with mean age of 69.4 years were studied. All of the patients were users of mineral oil for treating intestinal constipation. High-resolution computed tomography studies of these patients were blindly evaluated by two radiologists. RESULTS: Air-space consolidation with areas of fat density and crazy paving pattern were the most frequent findings. The lesions were bilateral in six cases and unilateral in two CONCLUSION: Air-space consolidation with areas of fat density, associated with a clinical history of mineral oil ingestion virtually indicates a diagnosis of exogenous lipoid pneumonia.

  6. Participação do colmo principal e dos afilhos na produtividade do arroz irrigado, em função da densidade de semeadura

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    Eduardo do Valle Lima

    2010-01-01

    Full Text Available Entre as práticas culturais a serem consideradas na implantação da cultura do arroz destaca-se a densidade de semeadura, que deve estabelecer, em grande parte, a participação do colmo principal e dos afilhos nos componentes da produção, possibilitando a obtenção da máxima produtividade. O trabalho teve como objetivo avaliar a participação do colmo principal e dos afilhos na produtividade de grãos de arroz, cv. IAC 102, no sistema irrigado por inundação, em função da densidade de semeadura. O experimento foi desenvolvido sob túnel plástico, em Botucatu (SP, em caixas d'água de cimento amianto de 500 L, contendo Neossolo Flúvico Ta Eutrófico, com profundidade de 30 cm. O delineamento experimental foi o inteiramente casualizado, com quatro repetições. As densidades de semeadura foram: 100, 200, 300, 400, 500 e 600 sementes viáveis por m², em 4 linhas de 1 m por caixa, espaçadas com 20 cm. A elevação da densidade de semeadura diminui o afilhamento e proporciona a maior participação dos colmos principais, porém, não resultando em incremento de produtividade, devido à plasticidade das plantas de arroz, que proporciona o ajustamento dos componentes da produção.

  7. DESPANOJADO Y DENSIDAD DE POBLACIÓN EN UNA CRUZA SIMPLE ANDROESTÉRIL Y FÉRTIL DE MAÍZ

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    Alejandro Espinosa-Calder\\u00F3n

    2010-01-01

    Full Text Available En este trabajo el objetivo fue determinar el efecto del despanojado en la productividad de cruzas simples de maíz. Se estableció un experimento durante el ciclo primavera - verano 2004, en el Rancho Almaraz de la Facultad de Estudios Superiores Cuautitlán, de la Universidad Nacional Autónoma de México (FESC-UNAM, ubicado en Cuautitlán Izcalli, México, a 2240 msnm. Se utilizó un diseño experimental de campo en bloques completos al azar con tres repeticiones, el análisis estadístico se efectuó en forma factorial, considerando los factores genotipos (2, densidades de población (3 y el tratamiento de despanojado y sin despanojar (2, así como las interacciones. El rendimiento tuvo diferencias altamente significativas para despanojado, así como significancia estadística para genotipos y densidad de población y la interacción densidad de población x despanojado. La cruza simple versión androestéril en promedio rindió 8873 kg/ha, superior estadísticamente (17,9% a la versión fértil que produjo 7521 kg/ha. La densidad de población de 80 000 plantas/ha con 9640 kg/ha, superó estadísticamente al rendimiento obtenido con 50 000 plantas/ha (7193 kg/ha. El testigo sin despanojar (9429 kg/ha superó estadísticamente al despanojado.

  8. Densidad y distribución sobre CSMA/CA en redes IEEE 802.11g en modo AD HOC

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    José Domínguez

    2010-09-01

    Full Text Available El propósito  principal de la presente investigación, fue determinar la influencia de la densidad y distribución de hosts sobre el control de acceso al medio en redes IEEE 802.11g, tomando como variables fundamentales la densidad y distribución de los mismos y el protocolo CSMA/CA para el acceso al medio de transmisión.  La investigación fue de tipo explicativa, con un diseño  experimental puro. La misma se basó en los postulados teóricos de Bates (2003, Comer (2000, León García (2001, Stallings (2005, Tanenbaum (2003, entre otros. El procedimiento a utilizar fue diseñado por el investigador y consistió de cuatro (04 fases: Enfoque teórico, experimentación, Recolección y análisis de los datos y elaboración de conclusiones y recomendaciones.  La cantidad de hosts a utilizar en la red se ubicó en seis 06 equipos portátiles con especificaciones técnica similares. Para la recolección de la información se diseño un (1 instrumento, tipo formato de datos, en el cual se registraron diez (10 parámetros diferentes para evaluar el desempeño de la red en diversos escenarios. Seguidamente se tabularon los datos en cuadros, para proceder al análisis cuantitativo de los mismos. Se concluye que la densidad y distribución de los hosts en redes IEEE 802.11g afectan el acceso al medio de transmisión.Palabras clave: Densidad, distribución, red, ad hoc, control de acceso al medio.

  9. Aplicación de relaciones de densidad-diámetro y de área potencial aprovechable en bosques de Nothofagus Dombeyi (mirb.) Oerst, como herramientas de planificación silvícola .

    OpenAIRE

    Cruz Johnson, Pablo Christian

    2013-01-01

    Uno de los objetivos de esta tesis de doctorado fue analizar la aplicación de relaciones de densidad ¿ diámetro en bosques de Nothofagus dombeyi (Mirb.) oerst, para la localidad del Río Mirta en la XI Región de Chile, como herramientas de planificación silvícola. El método de análisis consistió en la generación de una muestra de densidad¿diámetro a partir de la que se determinó el índice de densidad máximo (IDmax) a partir del cual se estimaron las máximas densidades que la especie podría alc...

  10. Comportamiento de híbridos de maíz con alta calidad de proteína, por su buen rendimiento y tolerancia al "Achaparramiento"

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    Mauro Sierra-Mac\\u00EDas

    2007-01-01

    Full Text Available Comportamiento de hí bri dos de maíz con al ta calidad de proteína, por su buen rendimiento y tolerancia al “Achapa rramiento”. Con los ob jetivos de conocer el rendimiento y las características agronómicas de híbridos de maíz con alta calidad de pro teí na (QPM e iden ti fi car los que me jor se adapten y presenten tolerancia a la enfermedad “Achaparramiento”, du ran te el ci clo primavera verano 2005 se establecieron experimentos en las localidades de Cotaxtla, municipio de Medellín de Bra vo, La To rrecilla, Municipio de Tlalixcoyan y Zapotal Número Uno, municipio de Ignacio de la Llave, en el estado de Ve racruz. Los ensayos fueron sembrados bajo un diseño alpha látice 9x2 con 18 tratamientos y tres repeticiones, en par ce las de dos sur cos de 5 m de lar go se pa ra dos a 80 cm, con una densidad de 62,500 plantas/ha. Durante el desarrollo del cultivo se registraron las variables: rendimiento de grano, porcentaje de plan tas y mazorcas dañadas por achaparramiento, se ve ri dad del da ño, al tu ra de plan ta y de ma zor ca, días a floración masculina y femenina, aspecto y sa nidad de planta y mazorca, porcentaje de plantas acamadas, porcentaje de mazorcas con mala cobertura y porcentaje de ma zorcas podridas. De los análisis de varianza combinados para: Rendimiento de grano, porcentaje de daño y severidad por achaparramiento en planta y porcentaje de mazorcas con achaparramiento, se encontró diferencia altamente significativa para híbridos (H y para localidades (L. La interacción HxL, excepto para rendimien to de gra no, en el res to de las va ria bles fue sig ni fi ca ti va. Los hí bri dos QPM que re gistraron el mayor rendimiento, toleran cia al achaparramiento y mejores características agronómicas fue ron: (CML264QxCML150xCML491, (CML264Qx CML273QxCML491, (CML144xCML159xCLQ-RCWQ50 y (CML492x CML150xCLQ-RCWQ50.

  11. Estudio del comportamiento durante la sinterización de mezclas WC-Co finas, ultrafinas y nanocristalinas obtenidas por molienda de alta energía

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    Salvador, M. D.

    2008-10-01

    Full Text Available In this work the sintering behaviour of fine, ultrafine and nanocrystalline WC-12Co mixtures obtained by high energy milling, as well as commercial nanopowders, have been studied, in order to evaluate the effect of the particle size and the powder processing, in the densification, microstructural development and mechanical properties of the final product. The consolidation of the mixtures has been made by uniaxial pressing and sintering in vacuum, and by hot isostatic pressing. The sintered materials have been evaluated by measures of density, hardness and indentation fracture toughness, and microstructurally characterized by optical microscopy and scanning and transmission electronic microscopy (SEM and TEM. The results show the improvements in resistant behaviour of the materials obtained from nanocrystalline powders, in spite of the grain growth experienced during the sintering. The best results were obtained for the milling nanocrystalline material, which presents values of hardness higher than 1800 HV.

    En este trabajo se ha estudiado el comportamiento, durante la sinterización, de mezclas WC-12Co finas, ultrafinas y nanométricas obtenidas por molienda de alta energía y de material nanométrico comercial, a fin de evaluar el efecto del tamaño de partícula y del proceso de obtención del polvo en la densificación, desarrollo microestructural y propiedades mecánicas del producto final. La consolidación de las mezclas se ha realizado mediante compactación uniaxial y sinterización en vacío y por compactación isostática en caliente. Los materiales sinterizados se han evaluado mediante medidas de densidad, dureza y tenacidad a fractura por indentación y se han caracterizado microestructuralmente mediante microscopía óptica y microscopía electrónica de barrido y de transmisión. Los resultados obtenidos ponen de manifiesto las mejoras en comportamiento resistente de los materiales obtenidos a partir polvos nanométricos, a

  12. Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus

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    Shu Meguro

    2014-01-01

    Full Text Available Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6%. Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was 71.2±22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r=−0.450, P<0.01, triglyceride (r=0.445, P<0.01, and high sensitive C-reactive protein (r=0.316, P<0.01 but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=−0.411, P<0.01 and high sensitive C-reactive protein (β=0.193, P<0.05. Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.

  13. Amide-linked Ethanolamine Conjugate of Gemfibrozil as a Profound HDL Enhancer: Design, Synthesis, Pharmacological Screening and Docking Study.

    Science.gov (United States)

    Rai, Himanshu; Dhaneshwar, Suneela S

    2015-01-01

    Elevated concentration of any or all types of lipids in the plasma including hypertriglyceridemia and hypercholesterolemia leads to atherosclerotic cardiovascular disease. Effective medication needs multiple drug therapy as recommended cholesterol and triglyceride levels are difficult to achieve by monotherapy and frequently require the use of more than one lipid-lowering medication. Gemfibrozil lowers plasma triglyceride-rich lipoproteins mainly VLDL and increases HDL. It is associated with short plasma half-life (1.5h) and GIT distress on long term use. In a study it was found that ethanolamine decreases serum cholesterol, especially VLDL cholesterol and LDL cholesterol in rats fed an HF/HC diet. In the present work, we thought of exploring the effect of co-drug of gemfibrozil with ethanolamine (GE-I) as a potential combination therapy for the management of mixed hyperlipidemia. Synthesis of GE-I was effected by CDI coupling. Structure was confirmed spectrally. Interestingly kinetic studies revealed that GE-I resisted chemical and enzymatic hydrolysis. In tritoninduced hyperlipidemia, significant lowering of serum lipid levels was observed. The hallmark of GEI was its profound effect on HDL level which was raised above the normal level by 15%. Docking study also supported modulatory effect of GE-I (docking score -7.012) on PPAR-α which was comparable to docking score of gemfibrozil (-9.432). These preliminary observations prompt us to consider GE-I as a novel, serendipitous, hybrid anti-hyperlipidemic new chemical entity which needs be studied extensively to prove it as an HDL enhancing anti-hyperlipidemic agent. PMID:26285608

  14. Variação da densidade básica da madeira de progênies de Eucalyptus urophylla em dois locais.

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    Maria Aparecida Mourão Brasil

    2009-09-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 Estudou-se neste trabalho a variação da densidade básica da madeira entre procedências e progênies de eucalipto plantados em duas localidades. As progênies de Eucalyptus urophylla originárias da ilha de Timor na Indonésia foram plantadas em Belo Oriente (MG e Linhares (ES no delineamento de blocos compactos em famílias (compact family blocks com 3 repetições no espaçamento de 3,0 x 2,0m. Após 4 anos as  árvores  foram amostradas ao nível do DAP com a sonda Pressler e sua densidade básica determinada pelo método do máximo teor de umidade. Os resultados mostraram que as progênies tiveram  comportamento similar nos dois locais. A maior variação entre progênies ocorreu naquelas provenientes da região Oebaha II. Os valores médios de densidade básica* das progênies não foram diferentes das procedências brasileiras utilizadas como testemunhas no experimento.

  15. Plasma lipids, lipoprotein metabolism and HDL lipid transfers are equally altered in metabolic syndrome and in type 2 diabetes.

    Science.gov (United States)

    Silva, Vanessa M; Vinagre, Carmen G C; Dallan, Luis A O; Chacra, Ana P M; Maranhão, Raul C

    2014-07-01

    Metabolic syndrome (MetS) refers to states of insulin resistance that predispose to development of cardiovascular disease and type 2 diabetes (T2DM). The aim was to investigate whether plasma lipids and lipid metabolism differ in MetS patients compared to those with T2DM with poor glycemic control (glycated hemoglobin > 7.0). Eighteen patients with T2DM, 18 with MetS and 14 controls, paired for age (40-70 years) and body mass index (BMI), were studied. Plasma lipids and the kinetics of a triacylglycerol-rich emulsion labeled with [(3)H]-triolein ([(3)H]-TAG) and [(14)C]-cholesteryl esters ([(14)C]-CE) injected intravenously followed by one-hour blood sampling were determined. Lipid transfers from an artificial nanoemulsion donor to high-density lipoprotien (HDL) were assayed in vitro. Low-density lipoprotein (LDL) and HDL cholesterol (mg/dl) were not different in T2DM (128 ± 7; 42 ± 7) and MetS (142 ± 6; 39 ± 3), but triacylglycerols were even higher in MetS (215 ± 13) than in T2DM (161 ±11, p < 0.05). Fractional clearance rate (FCR, in min(1)) of [(3)H]-TAG and [(14)C]-CE were equal in T2DM (0.008 ± 0.018; 0.005 ± 0.024) and MetS (0.010 ± 0.016; 0.006 ± 0.013), and both were reduced compared to controls. The transfer of non-esterified cholesterol, phospholipids and triacylglycerols to HDL was higher in MetS and T2DM than in controls (p < 0.01). Cholesteryl ester transfer and HDL size were equal in all groups. Results imply that MetS is equal to poorly controlled T2DM concerning the disturbances of plasma lipid metabolism examined here, and suggest that there are different thresholds for the insulin action on glucose and lipids. These findings highlight the magnitude of the lipid disturbances in MetS, and may have implications in the prevention of cardiovascular diseases. PMID:24719245

  16. Variação da densidade anofélica com o uso de mosquiteiros impregnados com deltametrina em uma área endêmica de malária na Amazônia Brasileira Variation of anopheles density with deltamethrin-impregnated mosquito nets in an endemic malaria area of the Brazilian Amazon

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    João Barberino Santos

    1999-04-01

    Full Text Available Em 1992, foi realizado um ensaio de campo com mosquiteiros impregnados com deltametrina, em uma área endêmica de malária no Município de Costa Marques, Rondônia. No período de baixa transmissão, os mosquiteiros impregnados (MI diminuíram a densidade vetorial no intradomicílio, de modo semelhante, porém, aos mosquiteiros não impregnados (NI na maioria das avaliações-controle. Por outro lado, na época de alta transmissão, os MI provocaram diminuição significante da média horária de anofelinos capturados, ao passo que, nas casas com NI, verificou-se aumento do número de mosquitos capturados. No peridomicílio, em geral, não houve diferença do número de anofelinos capturados entre MI e NI. No grupo MI, a espécie mais capturada foi o An. darlingi (63,2%, mais freqüente no peridomicílio, seguida pelo An. deaneorum (35,3%, mais freqüente no intradomicílio. Os MI diminuíram a densidade vetorial no intradomicílio pelo efeito excito-repelente, sem diminuí-la, contudo, no peridomicílio.In 1992 a survey on the use of deltamethrin-impregnated mosquito nets was conducted in the municipality of Costa Marques, Rondonia. In the intradomicile, impregnated nets decreased the vector density at rates similar to those for non-impregnated nets during low-transmission periods; during high anopheline density periods, they led to a significant reduction in vector density, while in the non-impregnated net group there was an increase in the number of anophelines captured. There was no change in vector density in the peridomicile. In the impregnated net group, the most frequently captured species was Anopheles darlingi (63.2%, found mostly in the peridomicile, while Anopheles deaneorum (35.3% was most frequent indoors. The impregnated mosquito nets' excitatory-repellent effect decreased the intradomiciliary vector density but did not alter density in the peridomicile.

  17. EFEK PEMBERIAN SUSU SAPI BUBUK TERHADAP KADAR SERUM HDL (HIGH DENSITY LIPOPROTEIN PADA TIKUS PUTIH (Rattus norvegicus GALUR WISTAR MODEL DIABETES MELITUS TIPE 2

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    Zakia Umami

    2015-05-01

    Full Text Available ABSTRACTThe purpose of this study was to determine the cow’s milk powder to increased serum levels of High Density Lipoprotein (HDL of white male rat model with diabetes mellitus type 2. The design of this study was a post-test control group study conducted in 30 male rats which randomly divided into five groups. Negative control group was the group of rats which fed normally, the positive control group was induced by streptozotocin (STZ without given cow’s milk, group P1, P2, P3 were given a normal diet and cow’s milk 0.9; 1.8, and 2.7 g orally every day. The results of this study were the levels of HDL in K(-=44.22 mg/dl, K(+=47.45 mg/dl, P1=56.56 mg/dl, P2=51.82 mg/dl, and P3=59.45 mg/dl. The conclusion was the milk powder was not significantly increase levels of HDL (p>0.05. More longer intervention was suggested for further research to get more significant of HDL level on type 2 diabetes mellitus.Keywords: HDL serum level, high fat diet, milk powder, streptozotocinABSTRAKTujuan penelitian ini adalah menganalisis pengaruh pemberian susu sapi bubuk terhadap peningkatan kadar serum High Density Lipoprotein (HDL tikus putih (Rattus norvegicus berjenis kelamin jantan model diabetes melitus (DM tipe 2. Penelitian ini menggunakan desain penelitian post test control group dengan 30 ekor tikus dibagi secara acak menjadi lima kelompok. Kelompok K(- adalah tikus yang diberi pakan normal, kelompok K(+ diinduksi dengan streptozotocin (STZ tanpa diberi susu, kelompok P1 sampai P3 diberi diet normal dan susu 0,9; 1,8, dan 2,7 g secara oral setiap hari. Hasil penelitian menunjukkan kadar HDL pada K(-=44,22 mg/dl, K(+=47,45 mg/dl, P1=56,56 mg/dl, P2=51,82 mg/dl, dan P3=59,45 mg/dl. Susu sapi bubuk mampu meningkatkan kadar HDL tikus model DM tipe 2 akan tetapi tidak signifikan (p>0,05. Perlu dilakukan penelitian lebih lanjut dengan waktu lama penelitian yang berbeda sehingga bisa berdampak yang lebih signifikan untuk kadar HDL pada DM tipe 2.Kata kunci

  18. Doença celíaca em tratamento: avaliação da densidade mineral óssea

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    Carvalho Cecília Noronha de Miranda

    2003-01-01

    Full Text Available OBJETIVO: comparar a densidade mineral óssea de crianças e adolescentes com doença celíaca em tratamento com controles sadios, e avaliar exames laboratoriais relacionados com o metabolismo do cálcio. MÉTODOS: foram estudados 30 pacientes com doença celíaca em dieta isenta de glúten, 17 crianças e 13 adolescentes, e 23 indivíduos saudáveis. Todos os pacientes e controles realizaram a densidade mineral óssea (DEXA, Lunar. Os pacientes realizaram dosagem sérica de cálcio total, cálcio ionizado, fósforo, magnésio, fosfatase alcalina e paratormônio. RESULTADOS: a média de peso, estatura e densidade mineral óssea dos adolescentes com doença celíaca foi menor do que dos controles (p<0,05, enquanto que não se observaram diferenças estatisticamente significantes destes parâmetros, comparando as crianças com doença celíaca com os controles. A proporção de adolescentes que iniciou dieta isenta de glúten após os dois anos de idade foi maior do que a de crianças (p<0,05. Os pacientes apresentaram níveis séricos normais de cálcio ionizado, cálcio total e paratormônio. CONCLUSÕES: a densidade mineral óssea dos adolescentes com doença celíaca em dieta isenta de glúten foi menor do que dos controles. Por outro lado, não houve diferença entre a densidade mineral óssea de crianças com doença celíaca e controles.

  19. Levels of high-density lipoprotein cholesterol (HDL-C among children with steady-state sickle cell disease

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    Seixas Magda O

    2010-08-01

    Full Text Available Abstract Background The search for sickle cell disease (SCD prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C in steady-state children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, anti-aggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. Methods We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records. Results Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P Conclusions We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesis.

  20. Plasma lipids, lipoprotein metabolism and HDL lipid transfers are equally altered in metabolic syndrome and in type 2 diabetes.

    Science.gov (United States)

    Silva, Vanessa M; Vinagre, Carmen G C; Dallan, Luis A O; Chacra, Ana P M; Maranhão, Raul C

    2014-07-01

    Metabolic syndrome (MetS) refers to states of insulin resistance that predispose to development of cardiovascular disease and type 2 diabetes (T2DM). The aim was to investigate whether plasma lipids and lipid metabolism differ in MetS patients compared to those with T2DM with poor glycemic control (glycated hemoglobin > 7.0). Eighteen patients with T2DM, 18 with MetS and 14 controls, paired for age (40-70 years) and body mass index (BMI), were studied. Plasma lipids and the kinetics of a triacylglycerol-rich emulsion labeled with [(3)H]-triolein ([(3)H]-TAG) and [(14)C]-cholesteryl esters ([(14)C]-CE) injected intravenously followed by one-hour blood sampling were determined. Lipid transfers from an artificial nanoemulsion donor to high-density lipoprotien (HDL) were assayed in vitro. Low-density lipoprotein (LDL) and HDL cholesterol (mg/dl) were not different in T2DM (128 ± 7; 42 ± 7) and MetS (142 ± 6; 39 ± 3), but triacylglycerols were even higher in MetS (215 ± 13) than in T2DM (161 ±11, p lipid metabolism examined here, and suggest that there are different thresholds for the insulin action on glucose and lipids. These findings highlight the magnitude of the lipid disturbances in MetS, and may have implications in the prevention of cardiovascular diseases.

  1. Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype.

    Science.gov (United States)

    Krause, Amanda; Mitchell, Claire; Essop, Fahmida; Tager, Susan; Temlett, James; Stevanin, Giovanni; Ross, Christopher; Rudnicki, Dobrila; Margolis, Russell

    2015-10-01

    Huntington disease (HD) is a progressive autosomal dominant neurodegenerative disorder, characterized by abnormal movements, cognitive decline, and psychiatric symptoms, caused by a CAG repeat expansion in the huntingtin (HTT) gene on chromosome 4p. A CAG/CTG repeat expansion in the junctophilin-3 (JPH3) gene on chromosome 16q24.2 causes a Huntington disease-like phenotype (HDL2). All patients to date with HDL2 have some African ancestry. The present study aimed to characterize the genetic basis of the Huntington disease phenotype in South Africans and to investigate the possible origin of the JPH3 mutation. In a sample of unrelated South African individuals referred for diagnostic HD testing, 62% (106/171) of white patients compared to only 36% (47/130) of black patients had an expansion in HTT. However, 15% (20/130) of black South African patients and no white patients (0/171) had an expansion in JPH3, confirming the diagnosis of Huntington disease like 2 (HDL2). Individuals with HDL2 share many clinical features with individuals with HD and are clinically indistinguishable in many cases, although the average age of onset and diagnosis in HDL2 is 5 years later than HD and individual clinical features may be more prominent. HDL2 mutations contribute significantly to the HD phenotype in South Africans with African ancestry. JPH3 haplotype studies in 31 families, mainly from South Africa and North America, provide evidence for a founder mutation and support a common African origin for all HDL2 patients. Molecular testing in individuals with an HD phenotype and African ancestry should include testing routinely for JPH3 mutations.

  2. Procesos de automatización cognitiva en alumnado con altas capacidades intelectuales

    Directory of Open Access Journals (Sweden)

    Juan Montero-Linares

    2013-05-01

    Full Text Available Proponemos desde el enfoque del procesamiento de la información, el estudio de características cognitivas que faciliten la identificación de las altas capacidades. A tal fin, elaboramos una tarea de habilidad de segmentación silábica que, a partir del modelo propuesto por Baddeley sobre la memoria de trabajo y la distinción entre procesos automáticos y controlados, nos permitiese comprobar las diferencias en cuanto a la capacidad de automatización de la información y si los indicadores propuestos en la misma, tenían suficiente poder clasificatorio o predictivo en la identificación de la alta capacidad intelectual. Participaron 480 niños y niñas de primero a cuarto de Educación Primaria. Se clasificaron, en función de su CI, en dos grupos: alumnado de altas capacidades y alumnado de capacidades medias. Se les administró una batería de pruebas entre las que se encontraba el test de habilidad de segmentación silábica, lo que permitió realizar su estandarización. Los resultados mostraron que los alumnos con CI superior a 130 fueron capaces de automatizar la segmentación de forma más eficiente que los de inteligencia media. La medición de los procesos automáticos a través del test de habilidad de segmentación silábica, permitió diferenciar a los participantes de altas capacidades de los que no lo eran.

  3. Compressão medular alta por cisto neuroentérico: relato de caso

    Directory of Open Access Journals (Sweden)

    Geraldo Pianettt Filho

    1993-06-01

    Full Text Available É relatado o caso raro de uma criança com cisto neuroentérico comprimindo a medula cervical alta de C1 a C3. A paciente foi submetida a laminectomia osteoplástica com retirada total do tumor. São discutidos a sintomatologia, o tratamento e o resultado satisfatório obtido. É feita revisão da literatura pertinente.

  4. Vital Signs – Presión arterial alta (High Blood Pressure)

    Centers for Disease Control (CDC) Podcasts

    2012-10-02

    En los EE. UU. casi un tercio de la población adulta tiene presión arterial alta, el principal factor de riesgo de enfermedades cardiacas y accidentes cerebrovasculares, dos de las principales causas de muerte en el país.  Created: 10/2/2012 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/17/2012.

  5. Inbreeding incidence on biological fitness in an isolated Mediterranean population: La Alta Alpujarra Oriental (Southeastern Spain)

    OpenAIRE

    Luna, Francisco; Valls, A.; Fernández Santander, Ana

    1998-01-01

    The incidence of parental inbreeding on biological fitness was analysed in a sample of the Alpujarrenian population. Fitness was estimated as the fertility and offspring viability from conception to reproductive age. The analysed sample represents about 45% of the population from the Alta Alpujarra Oriental in southeastern Spain, and includes 847 families and 2916 pregnancies. The results showed slightly higher reproduction in consanguineous marriages, but the differences observed were not st...

  6. Altas habilidades: uma questão escolar Giftedness: a shool matter

    Directory of Open Access Journals (Sweden)

    Célia Maria Paz Ferreira Barreto

    2011-12-01

    Full Text Available Esse estudo foi realizado em uma escola federal de ensino, localizada no Rio de Janeiro. Estabeleceu como objetivos gerais investigar as representações dos professores sobre as altas habilidades e a existência da indicação de alunos com esse perfil para atendimento. Utilizou duas amostras diferenciadas. A primeira, formada por 36 professores que atuavam do 1º ao 9º ano do ensino fundamental e do 1º ao 3º ano do ensino médio. A outra amostra foi constituída por quatro setores da escola responsáveis pelo registro histórico dos alunos. Utilizou-se a metodologia da análise de conteúdo no tratamento dos dados obtidos. Os resultados mostraram que os professores respondentes têm representações sobre altas habilidades e que não existem alunos com altas habilidades matriculados na instituição. Os resultados indicam urgência no implemento de ações inclusivas para as altas habilidades nessa escola, assim como a continuidade e aprofundamento nessa pesquisa.The study took place in a public federal school in Rio de Janeiro. The overall objectives were to investigate representations teachers have about giftedness and existing indications of such students that should be referred to specific learning and counseling programs. Two different groups were taken as samples. The first was made up of 36 elementary and high school teachers. The other consisted of four school sectors, charged with keeping students data records. The qualitative method of contents analysis was used. This study indicates its participants have representations about giftedness, although there were no gifted students enrolled in the institution where the study took place. The results also suggest that there is a pressing need to implement inclusive actions for gifted students at this school, as well as further developing the investigation at a deeper level.

  7. Relación entre paraoxonasa, otros componentes de HDL y estado inflamatorio en hemodiálisis

    Directory of Open Access Journals (Sweden)

    Ana Inés González

    2010-12-01

    Full Text Available La enfermedad renal crónica (ERC se asocia estrechamente con un estado pro-inflamatorio, aumento de lipoproteínas ricas en triglicéridos y disminución de HDL. La HDL contiene enzimas antioxidantes asociadas como la paraoxonasa (PON, cuya actividad en ERC se encuentra disminuida. Nuestro objetivo fue evaluar la relación entre la actividad de PON, apoA1, colesterol(col-HDL y Proteína C reactiva-altamente sensible (PCR-as como marcador de inflamación en pacientes en hemodiálisis. Se estudiaron n = 42 pacientes; edad, mediana (rango = 50 (25-67 años; sexo M/F = 22/20; antigüedad de hemodiálisis = 4.4 ± 0.5 años; índice de masa corporal (IMC = 23 ± 0.5 kg/m². Se obtuvo una muestra de sangre después de 12 h de ayuno y se determinaron los parámetros clásicos del perfil lipídico, se midieron los valores de apoproteínas A1 y B, PON a través de su actividad arilesterasa y PCR-as, la cual permitió dividir a los pacientes con PCR-as ≤ 1 (bajo riesgo, rango: 0.1 a 1.0 mg/l y > 1 mg/l (moderado y alto riesgo, 1.1 a 10.7 mg/l. Los niveles de triglicéridos, col-LDL y apoB no fueron diferentes entre los grupos. Los pacientes con PCR-as > 1 presentaron menor col-HDL (40 ± 2 mg/dl y apoA1 (118 ± 4 mg/dl que los pacientes con PCR-as ≤ 1 (50 ± 4 y 133 ± 5, respectivamente; p 1: 90.5 ± 24.0 μmol/ml.min que en PCR-as ≤ 1: 105.2 ± 18.0. Consecuentemente, se obtuvieron correlaciones inversas entre apoA1 y PCR-as, r = -0.381 p = 0.013 y entre PON y PCR-as, r = -0.32, p = 0.042. Además, el aumento de PCR-as correlacionó positivamente con el IMC, r = 0.318, p = 0.042. La disminución de col-HDL, apoA1 y PON en los individuos con mayor estado inflamatorio explicaría, en parte, el aumento de riesgo cardiovascular de estos pacientes, dado los efectos antiinflamatorios de la apoA1 y antioxidantes de la PON.

  8. USO DA INTERNET: DIFERENÇAS ENTRE CLASSE MÉDIA E ALTA

    Directory of Open Access Journals (Sweden)

    Jorge Ferreira da Silva

    2013-12-01

    Full Text Available Este estudo busca propor e testar um modelo que explique o uso da internet pelos jovens e identificar possíveis diferenças neste uso entre jovens de classe média e alta. A motivação para a pesquisa partiu da observação dos novos hábitos de consumo originados do uso da internet por estes jovens, que consideram a tecnologia indispensável em suas vidas. Baseado na literatura, o modelo final envolveu os seguintes fatores: Barreiras Percebidas ao Acesso, Comunicação, Interatividade e Uso da Internet. As hipóteses de pesquisa foram testadas por meio de uma survey com 394 jovens, com a amostra sendo divida em dois grupos: jovens de classe média e jovens de classe alta. Os dados foram analisados por modelagem de equações estruturais multigrupo. Os resultados sugerem diferenças na utilização de internet entre jovens de classe média e alta, com somente a classe média sendo influenciada significativamente pela Interatividade e Comunicação percebidas.

  9. Study on the Relationship between Blood Lipid LDL/HDL-C and ApoB/ApoA1 and Carotid Atherosclerosis%颈动脉粥样硬化与血脂LDL/HDL-C及ApoB/ApoA1的关系

    Institute of Scientific and Technical Information of China (English)

    丁毅

    2013-01-01

    Objective: To study the relationship between blood lipid LDL/HDL-C and ApoB/ApoA1 and carotid atherosclerosis. Method: 76 patients were investigated by ultrasonic apparatus to detect carotid atherosclerosis, to detect the value of LDL,HDL-C,ApoB ,ApoA1 ,LDL/HDL-C and ApoB/ApoA1 by automatic biochemistry analyzer of Hitachi 7600. Result: There were no significant difference in LDL and HDL -C between the carotid atherosclerosis group and the control group ( P〉0. 05 ). The ratios of LDL/HDL-C and ApoB/ApoAl were significant different between the two groups ( P 〈0. 05 ). The value of blood sugar and hemaleucin were significant different between the two groups ( P 〈0. 05 ), and the ratios of LDL/HDL-C and ApoB/ApoAl were associated with carotid atherosclerosis ( P〈0. 05 ). Conclusion: The formation of carotid plaque is related to increase the total blood cholesterol, low density lipoprotein and apolipoprotein B.%目的:研究颈动脉粥样硬化与血脂LDL/HDL-C及ApoB/ApoA1的关系.方法:对76例患者进行颈动脉超声检查,采用日立7600全自动生化测定仪测量LDL、HDL-C、ApoB、ApoA1、LDL/HDL-C及ApoB/ApoA1值的变化.结果:观察组和对照组患者的LDL和HDL-C之间差异不明显(P>0.05),LDL/HDL-C和AapoB/ApoA1的比值差异非常显著(P<0.05),血糖与纤维蛋白原的值也非常显著(P<0.05),且颈动脉粥样硬化程度与LDL/HDL-C、ApoB/ApoA1的比值存在显著相关性(P<0.05).结论:颈动脉粥样斑块的形成与血总胆固醇和低密度脂蛋白、载脂蛋白B的指标增高有关.

  10. Funcionalización de polietileno de baja densidad con anhídrido maleico en estado fundido

    Directory of Open Access Journals (Sweden)

    Manuel Guzmán

    2014-01-01

    Full Text Available En este estudio, polietileno de baja densidad (PEBD fue modificado con anhídrido maleico (AM en estado fundido usando concentraciones diferentes de peróxido de dicumilo (DCP (0.25, 0.50, 0.75 y 1.0 %. Los materiales obtenidos fueron caracterizados por contenido de gel, titulaciones ácido-base, análisis infrarrojo (IR, calorimetría de barrido diferencial (DSC, análisis termogravimétrico (TGA, análisis reológico, propiedades mecánicas, dureza y permeabilidad al oxígeno. El análisis reométrico indicó que el tiempo óptimo para obtener las mezclas es alrededor de 7.5 minutos. El análisis IR mostró que el AM fue injertado en el esqueleto del PEBD, el grado de injerto incrementó con el contenido de DCP y el más alto grado de injerto (1.12 ± 0.015 %, fue exhibido por la muestra obtenida empleando la mayor cantidad de DCP (1 %. La estabilidad térmica de las muestras funcionalizadas fue ligeramente mayor que la del PEBD. La cristalinidad de las muestras funcionalizadas fue diferente a la exhibida por el PEBD. El comportamiento reológico presentado por las muestras fue seudoplástico. Las propiedades mecánicas, dureza y la permeabilidad al oxigeno fueron dependientes de la cantidad de DCP y AM injertado en el PEBD.

  11. Tomografia computadorizada na avaliação da densidade de um solo do semi-árido brasileiro

    Directory of Open Access Journals (Sweden)

    L. Fante Junior

    2002-12-01

    Full Text Available A densidade do solo de amostras indeformadas foi determinada por meio das técnicas de tomografia computadorizada e do torrão impermeabilizado, visando à identificação de processos de compactação do solo e a comparação de métodos. A pesquisa também visou auxiliar um levantamento pedológico elaborado com fins de classificação de terras para irrigação. As amostras de solo foram coletadas da região semi-árida de Petrolina (PE, ao longo de perfis do solo, da superfície até 1 m de profundidade, em camadas de 0,1 m e em duas áreas distintas quanto à sua ocupação vegetal e manejo: (1 vegetação natural (caatinga; (2 área cultivada e irrigada por pivô central. As tomografias foram realizadas com um tomógrafo de primeira geração, constituído por uma fonte de radiação gama de 137Cs e um detetor cintilador de NaI(Tl, com eletrônica padrão de espectrometria gama e sistema de movimentação de amostra controlados por uma interface específica acoplada a um microcomputador. Na área de caatinga, os resultados evidenciam a ocorrência de um adensamento do solo em camadas mais profundas, abaixo de 0,4 m, bem como de uma camada adensada e, ou, compactada entre aproximadamente 0 e 0,4 m, na área cultivada com pivô central, possivelmente em virtude da ação de máquinas e implementos utilizados no preparo e cultivo do solo.

  12. Effects of extended-release niacin/laropiprant, simvastatin, and the combination on correlations between apolipoprotein B, LDL cholesterol, and non-HDL cholesterol in patients with dyslipidemia

    Directory of Open Access Journals (Sweden)

    Farnier M

    2014-05-01

    Full Text Available Michel Farnier,1 Erluo Chen,2 Amy O Johnson-Levonas,2 Christine McCrary Sisk,2 Yale B Mitchel21Point Médical, Dijon, France; 2Merck and Co, Inc., Whitehouse Station, NJ, USABackground: Statins modify correlations between apolipoprotein B (apoB and low-density lipoprotein cholesterol (LDL-C and apoB and non-high-density lipoprotein cholesterol (non-HDL-C; however, it is not known whether niacin-based therapies have similar effects.Objective: To evaluate the effects of extended-release niacin (ERN/laropiprant (LRPT, simvastatin (SIMVA, and ERN/LRPT + SIMVA (pooled ERN/LRPT + SIMVA on apoB:LDL-C and apoB:non-HDL-C correlations in dyslipidemic patients.Methods: This post-hoc analysis of a 12-week study evaluated the apoB:LDL-C and apoB:non-HDL-C correlations in dyslipidemic patients randomized equally to double-blind ERN/LRPT 1 g/20 mg, SIMVA 10, 20, or 40 mg, or ERN/LRPT 1 g/20 mg + SIMVA (10, 20, or 40 mg once daily for 4 weeks. At week 5, doses were doubled in all groups except SIMVA 40 mg (unchanged and ERN/LRPT 1 g/20 mg + SIMVA 40 mg (switched to ERN/LRPT 2 g/40 mg + SIMVA 40 mg. Simple linear regression analyses were used to calculate LDL-C and non-HDL-C levels corresponding to known apoB baseline values (ie, in untreated patients and following treatment.Results: The apoB:LDL-C and apoB:non-HDL-C correlations were higher and the predicted LDL-C and non-HDL-C levels for a known apoB value were considerably lower following treatment with ERN/LRPT, SIMVA and ERN/LRPT + SIMVA compared with untreated patients at baseline.Conclusion: Greater dissociation of apoB, LDL-C, and non-HDL-C targets occur following treatment with ERN/LRPT, SIMVA, and ERN/LRPT + SIMVA in patients with dyslipidemia. The achievement of more aggressive LDL-C and non-HDL-C goals in patients receiving lipid-modifying therapy may further reduce coronary risk by normalizing apoB-containing atherogenic lipoproteins.Keywords: apoB, LDL-C, non-HDL-C

  13. Anestesia espinal alta para mastoplastia reductora. Experiencia de tres años

    Directory of Open Access Journals (Sweden)

    Néstor Parets Correa

    2012-05-01

    Full Text Available Fundamento: la aplicación de anestesia neuroaxial espinal alta en las intervenciones quirúrgicas resulta un tema controversial. Objetivo: describir los resultados de la aplicación de anestesia neuroaxial espinal alta en intervenciones quirúrgicas para mastoplastia reductora. Métodos: estudio descriptivo realizado en el Hospital General Universitario Dr. Gustavo Aldereguía Lima, de Cienfuegos, desde junio de 2006 hasta junio de 2009, que incluyó 90 pacientes operadas, en las cuales se empleó anestesia neuroaxial espinal alta. Se analizaron las variables: edad, índice de masa corporal, saturación de HBO2, tensión arterial, frecuencia cardiaca, uso de analgesia preventiva, comportamiento de la  analgesia posoperatoria, estado de satisfacción, presencia de complicaciones, técnica quirúrgica, duración del acto quirúrgico y de la anestesia. Resultados: el 50 % tenía  entre 35 y 44 años; 46, 7 % estaban sobrepeso; el 80 % se operó de hipertrofia mamaria; en el 97, 8 % se utilizó la mastopalstia reductora; ninguna presentó cifras altas de tensión arterial antes ni después de la aplicación de la anestesia, el 41,1 % presentó cifras bajas de tensión arterial después de la anestesia; la frecuencia cardiaca estuvo baja en el 31, 1 % después de aplicada la anestesia y alta en el 4, 4 %. La analgesia posoperatoria fue buena en el 87, 8 % de las pacientes; no hubo compromiso ventilatorio en ningún caso y el 100 % mostró satisfacción con la técnica anestésica. Conclusiones: la aplicación de la técnica anestésica permite desarrollar exitosamente las intervenciones quirúrgicas con un mínimo de riesgos y complicaciones para las pacientes.

  14. Rural Electrification of Coban Municipality, Alta Verapaz Department (Guatemala) using Intigis Model; Electrificacion Rural en el Municipio de Coban, Departamento de Alta Verapaz (Guatemala) segun el Modelo Intigis

    Energy Technology Data Exchange (ETDEWEB)

    Dominguez Bravo, J.; Pinedo Pascua, I.; Auger Campos, C.; Cedillo Heine, A.; Gil Garcia, M.

    2009-05-15

    The present project started as an educational exercise for the Renewable Energies and Environment Masters given by the Polytechnic University of Madrid (UPM). It has been developed in collaboration with the research centre CIEMAT, the NGO Energy without Borders (ESF) and the University UPM, with the purpose of analyzing in a real context the application of Geographic Information Systems in renewable energies regional integration. The final aim of our study is to provide the isolated communities, specifically 13 communities in Alta Verapaz (Department of Coban, Guatemala), with the necessary conditions of electrification. This improvement will make possible the sustainable development of the area. Through the analysis of the geographic, technical and economic information gathered, using the IntiGIS methodology we will identify which is the most suitable autonomous generating system to cover the basic needs of the rural population in these Guatemalan communities. (Author) 9 refs.

  15. Avaliação de germoplasma de camomila e densidade de semeadura na produção e composição do óleo essencial Evaluation of germplasm and seeding rate over the production and composition of chamomile essential oil

    Directory of Open Access Journals (Sweden)

    Wanderlei do Amaral

    2012-06-01

    Full Text Available O cultivo de camomila na região Sul do Brasil tem sido realizado utilizando-se como material genético a cultivar Mandirituba. Apesar da produção de capítulos florais e teor de óleos essenciais apresentado por esta cultivar ser considerado satisfatório, tem sido observada nas regiões produtoras a ocorrência de problemas fitossanitários que resultam em perdas significativas da produção. Este trabalho teve como objetivos comparar materiais genéticos de camomila provenientes da Holanda, Dinamarca e Mandirituba, e avaliar o efeito de diferentes densidades de semeadura no desenvolvimento das plantas, produção de capítulos, rendimento e qualidade do óleo essencial da cultivar Mandirituba, atualmente cultivada na região. Os experimentos foram conduzidos no município de Piraquara (PR. A extração do óleo essencial foi realizada por hidrodestilação em aparelho tipo Clevenger e a determinação da composição do óleo foi feita por cromatografia em fase gasosa acoplada ao espectrômetro de massa (GC/MS. Os materiais genéticos provenientes da Holanda e de Mandirituba apresentaram maior produção de biomassa seca de capítulos, em relação ao material genético da Dinamarca. A cultivar Mandirituba apresentou o maior rendimento de óleo essencial (4,71 mL g-1 ms, sendo também superior em relação à produtividade de óleo essencial (2,40 L ha-1. Os materiais procedentes da Dinamarca e de Mandirituba apresentaram composição do óleo essencial semelhantes. A densidade de plantio de 1,0 kg ha-1 da cultivar Mandirituba resultou em melhor desenvolvimento das plantas e maior produção de óleo essencial. Quantidades superiores a 3,0 kg ha-1 de sementes não resultaram em maior densidade de plantas tendo em vista a alta competição e percentual de plântulas mortas.The cultivar Mandirituba is the only genetic material for chamomile cultivation in southern Brazil. Besides the limitations regarding floral buds and the yield of

  16. Cholesteryl Ester Transfer Protein (CETP polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk.

    Directory of Open Access Journals (Sweden)

    Audrey C Papp

    Full Text Available Polymorphisms in and around the Cholesteryl Ester Transfer Protein (CETP gene have been associated with HDL levels, risk for coronary artery disease (CAD, and response to therapy. The mechanism of action of these polymorphisms has yet to be defined. We used mRNA allelic expression and splice isoform measurements in human liver tissues to identify the genetic variants affecting CETP levels. Allelic CETP mRNA expression ratios in 56 human livers were strongly associated with several variants 2.5-7 kb upstream of the transcription start site (e.g., rs247616 p = 6.4 × 10(-5, allele frequency 33%. In addition, a common alternatively spliced CETP isoform lacking exon 9 (Δ9, has been shown to prevent CETP secretion in a dominant-negative manner. The Δ 9 expression ranged from 10 to 48% of total CETP mRNA in 94 livers. Increased formation of this isoform was exclusively associated with an exon 9 polymorphism rs5883-C>T (p = 6.8 × 10(-10 and intron 8 polymorphism rs9930761-T>C (5.6 × 10(-8 (in high linkage disequilibrium with allele frequencies 6-7%. rs9930761 changes a key splicing branch point nucleotide in intron 8, while rs5883 alters an exonic splicing enhancer sequence in exon 9.The effect of these polymorphisms was evaluated in two clinical studies. In the Whitehall II study of 4745 subjects, both rs247616 and rs5883T/rs9930761C were independently associated with increased HDL-C levels in males with similar effect size (rs247616 p = 9.6 × 10(-28 and rs5883 p = 8.6 × 10(-10, adjusted for rs247616. In an independent multiethnic US cohort of hypertensive subjects with CAD (INVEST-GENE, rs5883T/rs9930761C alone were significantly associated with increased incidence of MI, stroke, and all-cause mortality in males (rs5883: OR 2.36 (CI 1.29-4.30, p = 0.005, n = 866. These variants did not reach significance in females in either study. Similar to earlier results linking low CETP activity with poor outcomes in males, our results suggest genetic, sex

  17. Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk.

    Science.gov (United States)

    Papp, Audrey C; Pinsonneault, Julia K; Wang, Danxin; Newman, Leslie C; Gong, Yan; Johnson, Julie A; Pepine, Carl J; Kumari, Meena; Hingorani, Aroon D; Talmud, Philippa J; Shah, Sonia; Humphries, Steve E; Sadee, Wolfgang

    2012-01-01

    Polymorphisms in and around the Cholesteryl Ester Transfer Protein (CETP) gene have been associated with HDL levels, risk for coronary artery disease (CAD), and response to therapy. The mechanism of action of these polymorphisms has yet to be defined. We used mRNA allelic expression and splice isoform measurements in human liver tissues to identify the genetic variants affecting CETP levels. Allelic CETP mRNA expression ratios in 56 human livers were strongly associated with several variants 2.5-7 kb upstream of the transcription start site (e.g., rs247616 p = 6.4 × 10(-5), allele frequency 33%). In addition, a common alternatively spliced CETP isoform lacking exon 9 (Δ9), has been shown to prevent CETP secretion in a dominant-negative manner. The Δ 9 expression ranged from 10 to 48% of total CETP mRNA in 94 livers. Increased formation of this isoform was exclusively associated with an exon 9 polymorphism rs5883-C>T (p = 6.8 × 10(-10)) and intron 8 polymorphism rs9930761-T>C (5.6 × 10(-8)) (in high linkage disequilibrium with allele frequencies 6-7%). rs9930761 changes a key splicing branch point nucleotide in intron 8, while rs5883 alters an exonic splicing enhancer sequence in exon 9.The effect of these polymorphisms was evaluated in two clinical studies. In the Whitehall II study of 4745 subjects, both rs247616 and rs5883T/rs9930761C were independently associated with increased HDL-C levels in males with similar effect size (rs247616 p = 9.6 × 10(-28) and rs5883 p = 8.6 × 10(-10), adjusted for rs247616). In an independent multiethnic US cohort of hypertensive subjects with CAD (INVEST-GENE), rs5883T/rs9930761C alone were significantly associated with increased incidence of MI, stroke, and all-cause mortality in males (rs5883: OR 2.36 (CI 1.29-4.30), p = 0.005, n = 866). These variants did not reach significance in females in either study. Similar to earlier results linking low CETP activity with poor outcomes in males, our results suggest genetic, sex

  18. Spirulina platensis effects on the levels of total cholesterol, HDL and triacylglycerols in rabbits fed with a hypercholesterolemic diet

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    Luciane Maria Colla

    2008-04-01

    Full Text Available In this work, hypercholesterolemia was induced in rabbits by feeding them a high cholesterol diet (CD, 350 mg/d and the effects of supplementing this diet with 0.5 g/d Spirulina platensis was evaluated by measuring the levels of serum total-cholesterol (TC, triacylglycerols (TAG and high-density lipoprotein (HDL-cholesterol at the start of the experiment and after 30 d and 60 d. It was found that the levels of serum cholesterol decreased from 1,054±101 mg.dL-1 in the rabbits fed a CD without S. platensis to 516±163 mg.dL-1 to those fed with a high cholesterol diet supplemented with S. platensis (significant at p A microalga Spirulina é cultivada e comercializada no mundo devido a suas características nutricionais (elevada concentração de proteínas, em torno de 65%, vitaminas e sais minerais e ao seu potencial terapêutico no tratamento de inúmeras doenças, inclusive a hipercolesterolemia. Neste trabalho foi avaliada a inibição da hipercolesterolemia induzida em coelhos por uma dieta adicionada de colesterol (350 mg.d-1, pela suplementação de 0,5 g.dia-1 de biomassa de Spirulina platensis, sendo avaliados os níveis de colesterol total, triglicerídeos e HDL nos tempos de 0 d, 30 d e 60 d de tratamento. Os resultados indicaram que a adição de Spirulina platensis na dieta ocasionou decréscimo nos níveis de colesterol total de 1054±101 mg.dL-1 para 516±163 mg.dL-1 (p<0,0001, para os coelhos alimentados com a dieta colesterolêmica em comparação com os que receberam a dieta adicionada de Spirulina platensis. A adição de Spirulina a dieta colesterolêmica não ocasionou decréscimo significativo nos níveis de triglicerídios dos coelhos. Os valores de HDL aumentaram de 73±31 mg.dL-1 para 91,0±15,7 mg.dL-1, comparando-se os coelhos alimentados com a dieta colesterolêmica e os alimentados com a dieta adicionada de Spirulina, estatisticamente diferentes a um nível de significância maior que 0,1533.

  19. ESTRUTURA E POTENCIAL FUTURO DE UTILIZAÇÃO DA REGENERAÇÃO NATURAL DE FLORESTA DE VÁRZEA ALTA NO MUNICÍPIO DE AFUÁ, ESTADO DO PARÁ

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    José Roberto Soares Scolforo

    2003-05-01

    Full Text Available O presente estudo teve como objetivo analisar a estrutura e indicar as probabilidade de utilização futura da regeneração natural de uma floresta não-explorada de várzea alta localizada no município de Afuá (0° 09’ 24” S e 50° 23’ 12” W, ao norte do estado do Pará. Foram amostradas 29 subparcelas de 100 m2 nas quais se mediu a altura (h de árvores e palmeiras com h  0,30 m até o diâmetro a 1,30 m do nível do solo (DAP  15 cm, e o diâmetro das árvores compreendidas entre h  3,0 m até DAP  15 cm. A densidade total foi 30.969 indivíduos/ha, pertencentes a setenta espécies, 57 gêneros e 25 famílias botânicas, com índice de diversidade de Shannon (H’ de 2,68. As espécies mais importantes foram: Virola surinamensis, Euterpe oleracea, Astrocaryum murumuru, Geonoma laxiflora e Guarea guidonia. Muitas espécies são utilizadas como alimento pela fauna local, além de servirem como fonte de madeira e/ou, de produtos florestais não-madeireiros; algumas destas funcionam como complementação à dieta alimentar dos ribeirinhos, tais como: Eschweilera coriacea, Gustavia augusta, Inga Alba, Nectandra cf. risi e Protium spruceanum.

  20. Transferências lipídicas para HDL em diabéticos tipo 2: associações com microalbuminúria, estatina e insulina Transferencias lipídicas hacia HDL en diabéticos tipo 2: asociaciones con microalbuminuria, estatina y insulina Lipid transfer to HDL in type-2 diabetic patients: associations with microalbuminuria, statin, and insulin

    Directory of Open Access Journals (Sweden)

    Gilson Soares Feitosa-Filho

    2009-02-01

    Full Text Available FUNDAMENTO: O diabete melito tipo 2 (DM2 é um fator de risco isolado para coronariopatia, principalmente quando associado à microalbuminúria (MA. Alterações estruturais e funcionais das lipoproteínas não são totalmente esclarecidas nesse contexto. OBJETIVO: Avaliar a transferência de lípides para HDL (T em pacientes DM2 e a associação com a presença da MA e com o tratamento com estatina ou insulina. MÉTODOS: Estudamos 33 pacientes com DM2 e 34 controles pareados para idade. Uma nanoemulsão lipídica artificial radiomarcada com ³H-Triglicéride (TG e 14C-colesterol livre (CL ou ³H-colesterol éster (CE e 14C-fosfolípide (FL foi incubada com plasma. A nanoemulsão e as lipoproteínas foram precipitadas, exceto a HDL, que teve sua radioatividade contada. RESULTADOS: A TFL (% foi maior no grupo com DM2 que no grupo-controle (25,2±3,2 e 19,7±3,2 respectivamente; p FUNDAMENTO: La diabetes mellitus tipo 2 (DM2 es un factor de riesgo aislado para coronariopatía, principalmente cuando asociado a la microalbuminuria (MA. Alteraciones estructurales y funcionales de las lipoproteínas no están totalmente aclaradas en ese contexto. OBJETIVO: Evaluar no sólo la transferencia de lípidos hacia HDL (T en pacientes DM2, sino también la asociación tanto con la presencia de la MA como con el tratamiento con estatina o insulina. MÉTODOS: Estudiamos a 33 pacientes con DM2 y 34 controles pareados para edad. Se incubó con plasma una nanoemulsión lipídica artificial radiomarcada con ³H-Triglicérido (TG y 14C-colesterol libre (CL o ³H-colesterol esterificado (CE y 14C-fosfolípido (FL. Se procedió a la precipitación de la nanoemulsión y de las lipoproteínas, con excepción de la HDL, que tuvo su radioactividad contada. RESULTADOS: El valor de TFL (% resultó mayor en el grupo con DM2 en confrontación con el grupo-control (25,2±3,2 y 19,7±3,2 respectivamente; p BACKGROUND: Type-2 diabetes mellitus (T2DM is an isolated risk factor

  1. Assertion based verification methodology for HDL designs of primary sodium pump speed and eddy current flow measurement systems of PFBR

    International Nuclear Information System (INIS)

    With the growing complexity and size of digital designs, functional verification has become a huge challenge. The validation and testing process accounts for a significant percentage of the overall development effort and cost for electronic systems. Many studies have shown that up to 70% of the design development time and resources are spent on functional verification. Functional errors manifest themselves very early in the design flow, and unless they are detected upfront, they can result in severe consequences - both financially and from a safety viewpoint. This paper covers the various types of verification methodologies and focuses on Assertion Based Verification Methodology for HDL designs, taking as case studies, the Primary Sodium Pump Speed and Eddy Current Flow Measurement Systems of PFBR. (author)

  2. A Population Pharmacokinetic/Pharmacodynamic Model Predicts Favorable HDL Cholesterol Changes Over the First 5 Years in Children Treated With Current Efavirenz-Based Regimens.

    Science.gov (United States)

    Homkham, Nontiya; Cressey, Tim R; Ingsrisawang, Lily; Bouazza, Naïm; Ngampiyaskul, Chaiwat; Hongsiriwon, Suchat; Srirojana, Sakulrat; Kanjanavanit, Suparat; Bhakeecheep, Sorakij; Coeur, Sophie Le; Salvadori, Nicolas; Treluyer, Jean Marc; Jourdain, Gonzague; Urien, Saik

    2016-09-01

    Efavirenz use is associated with changes in cholesterol concentrations, but it is unclear whether this effect is related to drug concentrations. Using efavirenz and cholesterol plasma concentrations measured in 87 antiretroviral-naive children in Thailand, we assessed indirect response models to describe the evolution of high- and low-density lipoprotein (HDL, LDL) cholesterol concentrations in relation to efavirenz plasma concentrations over time where efavirenz was assumed to either stimulate cholesterol production or inhibit its elimination. Simulations of cholesterol evolution for children with different average efavirenz concentrations (Cav ) according to their assumed status of "fast" or "slow" metabolizers of efavirenz were performed. At treatment initiation, children's median (interquartile range, IQR) age was 8 years (5 to 10), body mass index z-score 0.01 (-1.05 to 1.44), HDL 31 mg/dL (24 to 44), and LDL 83 mg/dL (69 to 100). Median (IQR) efavirenz Cav was 1.7 mg/L (1.3 to 2.1) during the period of observation. The best model describing the evolution of HDL and LDL cholesterol concentrations over time assumed that efavirenz inhibited their elimination. HDL concentrations increase over 5 years, whereas LDL concentrations increased only during the first 4 months and then returned to baseline levels afterward. Simulations predicted that, after 3 years, HDL would increase to 63 mg/dL in "fast" metabolizers and 97 mg/dL in "slow" metabolizers of efavirenz. The population pharmacokinetic-pharmacodynamic (PK-PD) model shows that favorable HDL cholesterol changes can be expected in children with current efavirenz dosing guidelines over 5 years of treatment. PMID:26749102

  3. Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages

    Science.gov (United States)

    Carnuta, Mihaela G.; Sanda, Gabriela M.; Stancu, Camelia S.; Popescu, Andreea C.; Popescu, Mihaela R.; Vlad, Adelina; Dimulescu, Doina R.; Simionescu, Maya; Sima, Anca V.

    2016-01-01

    We aimed to determine the levels of microRNAs (miRNAs) in sera and HDL of acute coronary syndrome (ACS) compared to stable angina (SA) patients with/without hyperglycemia, and evaluate comparatively the functional effect of these sera on the processing machinery proteins (Drosha, DGCR8, Dicer) and miRNAs production in human macrophages. MiRNAs levels in sera and HDL from 35 SA and 72 ACS patients and 30 healthy subjects were measured by using microRNA TaqMan assays. MiR-223, miR-92a, miR-486, miR-122, miR-125a and miR-146a levels were higher in the hyperglycemic ACS compared to normoglycemic sera. MiR-223 and miR-486 prevailed in HDL2, while miR-92a predominated in HDL3, all three miRNAs discriminating between ACS and SA patients; their levels were increased in HDL from hyperglycemic ACS patients versus normoglycemic ones. The incubation of human macrophages with sera from ACS and SA patients showed that all patients’ sera induced an increase of Drosha, DGCR8 and Dicer expressions and of selected miRNAs levels compared to control sera, the effect being higher in the case of hyperglycemic versus normoglycemic ACS sera. The addition of glucose to SA and ACS sera increased Drosha, DGCR8 and Dicer expression and miRNAs levels in the exposed macrophages. In conclusion, hyperglycemia is associated with increased miR-223, miR-92a, miR-486 levels in HDL, which discriminate between ACS and SA patients. Exposure of human macrophages to ACS compared to SA sera determines the upregulation of Drosha, DGCR8 and Dicer expression and the increase of selected miRNAs production, the effect being augmented by an increased glucose concentration. PMID:27519051

  4. The atherogenic dyslipidemia ratio [log(TG/HDL-C] is associated with residual vascular risk, beta-cell function loss and microangiopathy in type 2 diabetes females

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    Hermans Michel P

    2012-10-01

    Full Text Available Abstract Background Atherogenic dyslipidemia (AD, defined as low HDL-C plus elevated triglycerides (TG, comorbid to T2DM, increases cardiometabolic risk for CAD even when LDL-C is at target. In T2DM males, AD was shown to correlate with β-cell function loss, yet it is not established whether this applies across gender. Aim To establish the prevalence and severity of AD in T2DM females, and to determine how it relates to cardiometabolic phenotype, glucose homeostasis, micro- and macrovascular complications, and 10-year absolute CV risk (UKPDS Risk Engine. Methods 340 T2DM females were ranked according to quintiles (Q of the continuous variable log(TG/HDL-C, with AD prevalence defined as HDL-C -1 plus TG ≥150 mg.dL-1, and β-cell function assessed with HOMA. Results AD prevalence was 35%; mean HDL-C and TG were 52 (15 and 160 (105 mg.dL-1. AD was significantly related to central fat, metabolic syndrome, sedentarity and skeletal sarcopenia, as well as to hsCRP, fibrinogen, uric acid, cystatin-C, Big ET-1, and 10-year UKPDS CV risk. AD correlated stepwise with lower β-cell function and hyperbolic product, and with accelerated loss of residual insulin secretion, higher HbA1c and prevalent microangiopathy. Conclusions log(TG/HDL-C is a simple means to grade AD and residual macrovascular risk in T2DM females. This ratio associates with major non-LDL cardiometabolic variables and ranks predicted CAD risk. In addition, log(TG/HDL-C identifies worsening glucose homeostasis, poorer glycemic control, and prevalent microangiopathy.

  5. Estabilidad fenotípica y densidades de planta de genotipos de estevia (Stevia rebaudiana Bert. en la región Caribe de Colombia

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    Alfredo Jarma Orozco

    2011-04-01

    Full Text Available Los estudios de estabilidad fenotípica son importantes para la siembra de genotipos que muestran un adecuado comportamiento en una o varias zonas. Estevia (Stevia rebaudiana Bert. es una especie recientemente introducida en Colombia, por tanto, los estudios sobre su adaptación en áreas productoras del país son escasos. Esta planta se caracteriza por sintetizar glucósidos de diterpeno altamente edulcorantes con bajo aporte calórico. El presente estudio se realizó en Montería (8° 52' N y 76° 48' O, Colombia, con el objeto de determinar la estabilidad fenotípica de los genotipos Morita 1 y Morita 2 de estevia, sembrados en tres densidades de plantas (25, 12.5 y 6.25 plantas/m² y dispuestos en un diseño de bloques completos al azar, en tres épocas de siembra en el Caribe húmedo de Colombia. Los resultados más importantes señalan que Morita 2, en densidades de 25 plantas/m², registró los mejores índices de estabilidad para el rendimiento de hoja seca/ha (Pig = 0; Pid = 0. Por su parte, éste mismo genotipo presentó una mayor relación hoja/tallo (1.17 ± 0.3 y mayor contenido de glucósidos totales (0.1586 ± 0.024 cuando la radiación solar fue mayor y las densidades eran entre 12.5 y 25 plantas/m².

  6. Fertilización y densidad de población en genotipos de maíz cultivados bajo condiciones de temporal

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    Octavio Cano

    2001-01-01

    Full Text Available Fertilización y densidad de población en genotipos de maíz cultivados bajo condiciones de temporal. Durante el ciclo Primavera - Verano1998/98 se condujo una investigación en el Campo Experimental Cotaxtla, Veracruz, México, con los objetivos de conocer la respuesta de cinco genotipos de maíz a la fertilización y densidad de población. El experimento se estableció bajo un diseño de bloques al azar con dos repeticiones y un arreglo de tratamientos en parcelas subdivididas, donde la parcela chica fueron los genotipos (G: VS- 536, H-512, H-513, HTV-1 y HTV-2, las parcelas medias los tratamientos de fertilización (F de N2,P2O5,K2O : 161-46-0, 184-69-0, 184-69-30, 207-92-0 y 207-92-30 y las parcelas grandes las densidades (D: 50; 62,5; 75; 93,75; 100 y 125 miles de pl/ha. Las variables estudiadas fueron el índice de cosecha, el porcentaje de plantas jorras (sin mazorca y rendimiento de grano. Los análisis de varianza mostraron significancia para algunas variables en D, F, DxF y DxG y para todas en G. De acuerdo a lo anterior, el mejor genotipo fue el híbrido promisorio HTV-1 con rendimiento de 6,74 t/ha. La respuesta de fertilización sólo se dio en el índice de cosecha, donde con el tratamiento 184-69-0 se obtuvo el mayor valor (0,446. Con 62500 pl/ha todos los genotipos presentaron su mayor rendimiento y bajos porcentajes de plantas “jorras”

  7. EVALUACIÓN DE DENSIDADES DE SIEMBRA EN Solanum sessiliflorum dunal “COCONA” Y SU EFECTO EN EL RENDIMIENTO DE FRUTO

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    Rodrigo Gonzáles Vega

    2012-12-01

    Full Text Available La cocona es una especie vegetal nativa de América Tropical, cuyos frutos maduros son ricos en hierro, vitamina B5 (Niacina, se utilizan en la preparación de jugos, refrescos, jarabes y ensaladas. El estudio se realizó en el Campo Experimental “El Dorado” de Estación Experimental San Roque, del INIA Loreto con el objetivo principal de determinar el mejor distanciamiento para establecer plantaciones comerciales de Solanum sessiliflorum dunal “Cocona”, en condiciones de suelos no inundables o de altura. Se evaluaron cuatro densidades de siembra 2,0m x 2,0m; 1,5m x 1,5m, 2,0m x 1,0 y 1,5m x 1,0m. Las variables evaluadas fueron el número de frutos, peso de frutos y rendimiento de frutos por cada tratamiento en estudio, el diseño experimental utilizado fue Bloques Completos al Azar (DBCA, con cuatro repeticiones, los datos fueron analizados mediante el Análisis de Variancia y Prueba Estadística de Tukey, usando el software SPSS, versión 10. De los resultados Obtenidos se determinó que la densidad 1,5m x 1,0m (6 666 plantas/ha, produjo el mejor rendimiento con 14 600 kg/ha de fruto, superando significativamente a los tratamientos 2m x 1,0, 1,5m x 1,5m y 2,0 x 2,0m, que alcanzaron rendimientos de fruto de 12020, 11 330 y 10 570 kg/ha, respectivamente. Se concluye que la densidad de siembra influye en el rendimiento de fruto, así a menor número de plantas, mayor número y peso de fruto por planta se obtiene un menor rendimiento de fruto/ha.

  8. Estabilidad fenotípica y densidades de planta de genotipos de estevia (Stevia rebaudiana Bert. en la región Caribe de Colombia

    Directory of Open Access Journals (Sweden)

    Jarma Orozco Alfredo

    2011-06-01

    Full Text Available Los estudios de estabilidad fenotípica son importantes para la siembra de genotipos que muestranun adecuado comportamiento en una o varias zonas. Estevia (Stevia rebaudiana Bert. es una especierecientemente introducida en Colombia, por tanto, los estudios sobre su adaptación en áreas productorasdel país son escasos. Esta planta se caracteriza por sintetizar glucósidos de diterpeno altamenteedulcorantes con bajo aporte calórico. El presente estudio se realizó en Montería (8º 52' N y 76º 48'O, Colombia, con el objeto de determinar la estabilidad fenotípica de los genotipos Morita 1 y Morita 2de estevia, sembrados en tres densidades de plantas (25, 12.5 y 6.25 plantas/m2 y dispuestos en undiseño de bloques completos al azar, en tres épocas de siembra en el Caribe húmedo de Colombia. Losresultados más importantes señalan que Morita 2, en densidades de 25 plantas/m2, registró los mejoresíndices de estabilidad para el rendimiento de hoja seca/ha (Pig = 0; Pid = 0. Por su parte, éste mismogenotipo presentó una mayor relación hoja/tallo (1.17 ± 0.3 y mayor contenido de glucósidos totales(0.1586 ± 0.024 cuando la radiación solar fue mayor y las densidades eran entre 12.5 y 25 plantas/m2.

  9. Plant densities of Urochloa decumbens in coexistence with Corymbia citriodoraDensidades de plantas de Urochloa decumbens em convivência com Corymbia citriodora

    Directory of Open Access Journals (Sweden)

    Jose Iran Cardoso Silva

    2011-12-01

    Full Text Available This study aimed to evaluate the effects of plant densities of Urochloa decumbens on the early growth of Corymbia citriodora. The experimental design was completely randomized design with four replications, each plot consisted of a of 60 L capacity vase. The signal grass densities were 0, 20, 40, 80 and 160 plants m-2, along with one eucalyptus plant. At the end of eight months of living together increase in height and in diameter and plant dry mass of eucalyptus and signal grass were carried out. The eucalyptus characteristics were influenced by all the weed populations, the effect being more pronounced with the increasing of grass density.O presente estudo teve como objetivo avaliar os efeitos da convivência de densidades crescentes de plantas Urochloa decumbens no crescimento inicial de plantas de Corymbia citriodora. O delineamento experimental adotado foi inteiramente casualisado, com quatro repetições; cada parcela constou de um vaso de 60 L de capacidade. As densidades de capim-braquiária foram: 0, 20, 40, 80 e 160 plantas m-2, juntamente com uma planta de eucalipto. Foram realizadas, ao final de oito meses de convivência, as avaliações de: incremento em altura e em diâmetro e massa seca das plantas de eucalipto e de capimbraquiária. Para todas as características estudadas a população infestante influenciou no desenvolvimento das plantas de eucalipto, sendo o efeito mais acentuado à medida que se aumentou a densidade de plantas de capim-braquiária.

  10. GÉNEROS BACTERIANOS DOMINANTES EN LOS ESTRATOS FOLIARES DEL TABACO CURADO PARA CAPAS. INFLUENCIA DE LA NICOTINA Y EL pH SOBRE SU DENSIDAD POBLACIONAL

    Directory of Open Access Journals (Sweden)

    Yunior M. Morán Gómez

    2013-01-01

    Full Text Available Aunque las bacterias juegan un papel importante en el proceso fermentativo del tabaco, en Cuba no se han identificado los géneros presentes en el tabaco curado para capas, ni las variables que afectan a sus poblaciones. Este conocimiento pudiera contribuir al manejo de los procesos en los que estos microorganismos intervienen. El objetivo de esta investigación fue determinar la relación que existe entre la densidad poblacional de los géneros bacterianos dominantes en los diferentes estratos foliares de la planta de tabaco luego de la curación y la concentración de nicotina y los valores de pH en estos ambientes. Se realizó el aislamiento e identificación genérica de la microbiota bacteriana y se determinó el contenido de nicotina y el pH de las hojas de tabaco para cada estrato foliar. Las poblaciones de Bacillus en todos los estratos foliares siempre fueron superiores a otros géneros aislados como Staphylococcus y Arthrobacter . Desde los niveles foliares inferiores hasta los superiores el contenido de nicotina se incrementó significativamente, el pH mostró una ligera disminución (no significativa p<0,01 y disminuyó la densidad poblacional de bacterias de todos los géneros aislados. El modelo de regresión reveló que la disminución de la densidad poblacional de los géneros bacterianos que se aprecia al ascender por los diferentes niveles foliares estuvo más relacionada con el incremento de la concentración de nicotina en las hojas que con la variación del pH.

  11. Efeitos do treinamento resistido na lipoproteína de baixa densidade Effects of resistance training on low density lipoprotein

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    Jeferson Luis da Silva

    2010-02-01

    Full Text Available Os benefícios da prática regular do exercício físico estão claramente estabelecidos na literatura. Entretanto, a escolha do tipo de exercício ideal pode ser mais salutar para indivíduos com doenças específicas e patologias associadas. O propósito desta revisão foi verificar se o treinamento resistido (TR exerce alguma alteração no colesterol da lipoproteína de baixa densidade (LDL-C. Foram observadas grandes diferenças na literatura, dificultando uma conclusão em relação aos benefícios do TR nesta revisão. No entanto, foi visto que o TR pode ser promissor na redução dos níveis de LDL-C, principalmente em homens e mulheres adultos, em pacientes com diabetes mellitus tipo 1 e tipo 2 e em mulheres pré-menopausa, não mostrando diferenças na população idosa. Os autores concluem que o TR é uma boa opção de exercício físico para indivíduos, principalmente quando o treinamento aeróbio (TA é contraindicado.The benefits of exercise regular practice are clearly established in the literature. However, the choice of the ideal exercise may be more beneficial for individuals with specific diseases and associated pathologies. The aim of this review was to determine whether resistance training (RT promotes any change on low density lipoprotein cholesterol. Important differences were observed in research protocols, making it difficult to define the benefits of RT in this review. However, it was noticed that RT may be promising in reducing LDL-C levels mainly in adult men and women, in patients with diabetes mellitus type 1 and type 2 and in pre-menopausal women, not presenting differences in the elderly population. It was concluded that the RT is an option good of physical exercise for individuals, especially when the aerobic training (AT is contra-indicated.

  12. Densidade mineral óssea de adolescentes com sobrepeso e obesidade Bone mineral density in overweight and obese adolescents

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    Fernanda Cobayashi

    2005-08-01

    Full Text Available OBJETIVO: Estudar a densidade óssea como fator concomitante da obesidade em adolescentes pós-púberes, controlando outras variáveis que possam interferir nessa relação. MÉTODOS: Estudo com 83 sobrepesos e obesos (IMC > P85 e 89 não obesos (P5 OBJECTIVE: to study bone density as a concomitant factor for obesity in post-pubertal adolescents, controlling for other variables that may interfere in such a relation. METHODS: Study comprising 83 overweight and obese adolescents (BMI > P85 and 89 non obese ones (P5 < BMI < P85. Cases and controls were selected out of 1,420 students (aged 14-19 from a public school in the city of São Paulo. The bone mineral density of the lumbar spine (L2-L4 in g/cm² was assessed by dual-energy x-ray absorptiometry (LUNAR™ DPX-L. The variable bone density was dichotomized using 1.194 g/cm² as cutoff point. Bivariate analyses were conducted considering the prevalence of overweight and obesity followed by multivariate analysis (logistic regression according to a hierarchical conceptual model. RESULTS: The prevalence of bone density above the median was twice more frequent among cases (69.3% than among controls (32.1%. In the bivariate analysis such prevalence resulted in an odds ratio (OR of 4.78. The logistic regression model showed that the association between obesity and mineral density is yet more intense with an OR of 6.65 after the control of variables related to sedentary lifestyle and intake of milk and dairy products. CONCLUSION: Obese and overweight adolescents in the final stages of sexual maturity presented higher bone mineral density in relation to their normal-weight counterparts; however, cohort studies will be necessary to evaluate the influence of such characteristic on bone resistance in adulthood and, consequently, on the incidence of osteopenia and osteoporosis at older ages.

  13. Modelagem da Densidade do Solo em Profundidade sob Vegetação Nativa em Minas Gerais

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    Eduane José de Pádua

    2015-06-01

    Full Text Available A densidade do solo (Ds é um importante indicador da qualidade física do solo, mas há pouca disponibilidade de informações sobre seus valores a maiores profundidades em razão da dificuldade amostral envolvida. Portanto, funções de pedotransferência têm sido utilizadas para estimar a Ds com relativo êxito, mas ainda sem especificidade aos diferentes biomas brasileiros. O objetivo deste trabalho foi desenvolver funções matemáticas capazes de descrever a Ds até 1 m de profundidade em áreas de vegetação nativa das regiões central e sul de Minas Gerais. A Ds foi amostrada pelo método do anel volumétrico em 53 perfis de solo de diferentes ordens, em seis profundidades (0-5, 5-10, 10-20, 30-40, 50-60 e 90-100 cm. A Ds variou entre 0,66 e 1,74 kg dm-3, com média de 1,25 kg dm-3, e foi geralmente menor nas camadas de 0-5 e 5-10 cm. Por meio de regressão linear múltipla (stepwise, foram gerados modelos com base nas propriedades químicas de rotina e granulometria, que permitiram estimar a Ds até 1 m de profundidade. Os teores de C orgânico do solo, areia, silte e argila e a capacidade de troca catiônica potencial (T foram as variáveis de maior relevância nos modelos, que alcançaram maior acurácia para a ordem Latossolos (R2ajust = 0,85, seguida por Cambissolos (R2ajust = 0,69, Nitossolos (R2ajust = 0,67 e Argissolos (R2ajust = 0,51. Uma vez que a modelagem para a base de dados completa atingiu R2ajust de 0,50, pode-se concluir que a estratificação por ordem taxonômica foi útil para melhorar os ajustes obtidos, com exceção da ordem Argissolo.

  14. APOA1-75 G to A Substitution Associated with Severe Forms of CAD, Lower Levels of HDL and apoA-I among Northern Indians

    Directory of Open Access Journals (Sweden)

    S. Chhabra

    2005-01-01

    DVD, TVD was 1.3, 2.8 and 4.2 respectively (ptrend = 0.007. Analysis of intergenotypic variations in the lipid profile revealed significantly lower levels of HDL and apoA-I among ‘A’ allele carriers as compared to GG (patients. Our study, first of its kind from India, suggests that ‘A’ allele may contribute to severity of CAD and low levels of HDL & apoA-I. However, an in depth study with a larger set of sample is necessary.

  15. Total physical activity might not be a good measure in the relationship with HDL cholesterol and triglycerides in a multi-ethnic population: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    de Munter Jeroen SL

    2011-11-01

    Full Text Available Abstract Background Evidence suggests that physical activity (PA has a beneficial effect on high-density lipoprotein cholesterol (HDL and triglycerides. However, observational studies show contrasting results for this association between different ethnic groups. It is unclear whether this is due to differences in the PA composition. The aim of this study was to assess the relationship of the total PA, along with its intensity and duration, with HDL and triglycerides in a multi-ethnic population. Methods The study population was sampled from the SUNSET study and included: 502 European- Dutch, 338 Hindustani-Surinamese, and 596 African-Surinamese participants living in Amsterdam, the Netherlands. We assessed PA with the SQUASH questionnaire. We calculated age-sex-adjusted betas, geometric mean ratios (GMRs, and prevalence ratios (PRs to assess the relationship of PA with HDL and triglycerides. Results In the adjusted models, the highest total PA tertile compared to the lowest tertile was beneficially associated with HDL (beta: 0.08, 95% CI: 0.00, 0.16 and PR low HDL 0.59, 95% CI: 0.39, 0.88 and triglycerides (GMR: 0.93, 95% CI: 0.83, 1.03 and PR: 0.56, 95% CI: 0.29, 1.08 for the African-Surinamese. No statistically significant associations appeared for total PA among the European-Dutch and Hindustani-Surinamese. The adjusted models with the intensity score and HDL showed beneficial associations for the European-Dutch (beta: 0.06, 95% CI: 0.03, 0.10 and African-Surinamese (beta: 0.06, 0.02, 0.10, for log triglycerides for the European-Dutch (beta: -0.08, 95% CI: -0.12, 0.03, Hindustani-Surinamese (beta: -0.06, 95% CI: -0.16, 0.03, and African-Surinamese (beta: -0.04, 95% CI: -0.10, 0.01. Excepting HDL in African-Surinamese, the duration score was unrelated to HDL and triglycerides in any group. Conclusions Activity intensity related beneficially to blood lipids in almost every ethnic group. The activity duration was unrelated to blood lipids, while

  16. Effects of extended-release niacin/laropiprant, simvastatin, and the combination on correlations between apolipoprotein B, LDL cholesterol, and non-HDL cholesterol in patients with dyslipidemia

    Science.gov (United States)

    Farnier, Michel; Chen, Erluo; Johnson-Levonas, Amy O; McCrary Sisk, Christine; Mitchel, Yale B

    2014-01-01

    Background Statins modify correlations between apolipoprotein B (apoB) and low-density lipoprotein cholesterol (LDL-C) and apoB and non-high-density lipoprotein cholesterol (non-HDL-C); however, it is not known whether niacin-based therapies have similar effects. Objective To evaluate the effects of extended-release niacin (ERN)/laropiprant (LRPT), simvastatin (SIMVA), and ERN/LRPT + SIMVA (pooled ERN/LRPT + SIMVA) on apoB:LDL-C and apoB:non-HDL-C correlations in dyslipidemic patients. Methods This post-hoc analysis of a 12-week study evaluated the apoB:LDL-C and apoB:non-HDL-C correlations in dyslipidemic patients randomized equally to double-blind ERN/LRPT 1 g/20 mg, SIMVA 10, 20, or 40 mg, or ERN/LRPT 1 g/20 mg + SIMVA (10, 20, or 40 mg) once daily for 4 weeks. At week 5, doses were doubled in all groups except SIMVA 40 mg (unchanged) and ERN/LRPT 1 g/20 mg + SIMVA 40 mg (switched to ERN/LRPT 2 g/40 mg + SIMVA 40 mg). Simple linear regression analyses were used to calculate LDL-C and non-HDL-C levels corresponding to known apoB baseline values (ie, in untreated patients) and following treatment. Results The apoB:LDL-C and apoB:non-HDL-C correlations were higher and the predicted LDL-C and non-HDL-C levels for a known apoB value were considerably lower following treatment with ERN/LRPT, SIMVA and ERN/LRPT + SIMVA compared with untreated patients at baseline. Conclusion Greater dissociation of apoB, LDL-C, and non-HDL-C targets occur following treatment with ERN/LRPT, SIMVA, and ERN/LRPT + SIMVA in patients with dyslipidemia. The achievement of more aggressive LDL-C and non-HDL-C goals in patients receiving lipid-modifying therapy may further reduce coronary risk by normalizing apoB-containing atherogenic lipoproteins. PMID:24855368

  17. Fabricación y comportamiento de espumas de aluminio con diferente densidad a partir de un precursor AlSi12

    Directory of Open Access Journals (Sweden)

    Gutiérrez-Vázquez, J. A.

    2010-06-01

    Full Text Available Closed cell aluminium foams were prepared by powder metallurgical method in three different ranges of density using AlSi12 precursor. The objective has been to determine by means of tests the effect that has the density of these materials regarding its mechanical behaviour. The used precursor contained 0.4% of foaming agent of titanium hydride (TiH2, mixed with aluminum and silicon in appropriate amounts to achieve the commercial composition of the AlSi12 precursor. Once cut the samples thermal treatments of foaming were made of 630 °C to 750 °C, by 3 to 20 minutes. The best solidification conditions were determined to avoid the collapse by means of forced air. The samples were prepared with the same weight to different densities, having itself obtained that the best mechanical behaviour was achieved in the high density foams, of 0.70 to 0.81 g/cm3.

    Se han fabricado espumas de aluminio de poro cerrado, de tres diferentes rangos de densidad, utilizando un precursor AlSi12 producido por pulvimetalurgia. El objetivo ha sido determinar el efecto que tiene la densidad de estos materiales respecto a su comportamiento mecánico. El precursor utilizado contenía un 0,4 % de hidruro de titanio (TiH2 como agente espumante, mezclado con aluminio y silicio en cantidades adecuadas para lograr la composición comercial del precursor AlSi12. Una vez cortadas las muestras, se efectuaron tratamientos térmicos de espumación entre 630 y 750 °C, a tiempos de espumación variables entre 3 y 20 min. Se determinaron las mejores condiciones de solidificación para evitar el colapso mediante aire forzado. Las muestras se prepararon con el mismo peso a diferentes densidades, habiéndose obtenido, que el mejor comportamiento mecánico se lograba en las espumas de mayor densidad, comprendidas entre 0,70 y 0,81 g/cm3.

  18. PRODUCCIÓN DE SEMILLA DE LÍNEAS PROGENITORAS DE MAÍZ: DENSIDAD DE POBLACIÓN E INTERACCIÓN

    Directory of Open Access Journals (Sweden)

    Juan Virgen-Vargas

    2014-01-01

    Full Text Available Producción de semilla de líneas progenitoras de maíz: densidad de población e interacción. El objetivo del presente estudio fue determinar los efectos de la localidad y la densidad de población en la producción de semilla de líneas progenitoras de híbridos de maíz de Valles Altos de México. En el período de 2006 a 2008, en Coatlinchán, Texcoco, Estado de México (2250 msnm se sembraron 16 líneas progenitoras de los híbridos: H-40, H-48, H-50, H-52, H-64E, H-66, H-68E, H-70, H-72E, H-74E, H-76E y H-78E en dos densidades de población 82 500 y 62 500 plantas/ha en un diseño de Bloques Completos al Azar con tres repeticiones. Hubo diferencias significativas (p≤0,05 entre líneas, densidad de población y años. Las líneas promediaron entre 73 y 78, y entre 82 y 83 días para inicio y floración media masculina y femenina, respectivamente. El rendimiento varió entre 7744 y 1484 kg/ha, con 86 y 14% de semilla grande y peso hectolítrico entre 70 y 57 kg/hl. Con 82 500 plantas/ ha se incrementó en 13% el rendimiento de semilla y disminuyó 2,5% el peso de mil semillas, en comparación con 62 500 plantas/ha. Entre años, el inicio y floración media masculina y femenina varió entre tres y cuatro días; en el 2008 el rendimiento y el peso hectolítrico fueron mayores (4427 kg/ ha y 71,75 kg/hl, en 2007 hubo 46,93 y 29,59% más semilla grande que en el 2006 y 2008; mientras que en el 2006 el rendimiento fue 25,30% menor al promedio del 2007-2008. Para determinar cuándo y dónde producir semilla híbrida es indispensable conocer la línea, la localidad de producción y la interacción del genotipo con el ambiente.

  19. LA DENSIDAD Y TAMAÑO DE PLÁNTULAS CON CEPELLÓN EN LA PRODUCCIÓN DE ESPÁRRAGO VERDE

    Directory of Open Access Journals (Sweden)

    Ana Mar\\u00EDa Castagnino

    2011-01-01

    Full Text Available Con el objetivo de determinar la influencia del tamaño de la celda utilizada para la obtención de plántulas de espárrago y la densidad o marco de plantación empleado, sobre la producción de turiones, se evaluó en invernadero tres tamaños de celda: 1 PG: grande (70 cm3, 2 PM: mediana (30 cm3 y 3 PCh: pequeña (20 cm3 y tres densidades (35 714 (D1; 23 810 (D2 y 17 857 (D3 plantas/ha. Se efectuó un trabajo en la Chacra Experimental de la Facultad de Agronomía, en Azul, provincia de Buenos Aires. La plantación en el campo se efectuó en noviembre 2002, setenta días después de la siembra del almácigo con plántulas con cepellón. La cosecha se realizó del 25/09 al 18/10 del año 2006, en el cuarto año desde la plantación, con una frecuencia de cosecha de día por medio. Se realizó un análisis de la varianza, con un diseño completamente al azar y considerando como factor: el tamaño de las plántulas que provenían de cada contenedor y tres densidades. En el segundo año evaluado, la densidad D1 fue la de mayor producción (4450 kg/ha netos totales y mayor cantidad de turiones (380 166. Las plantas provenientes de los dos mayores tamaños de celda produjeron 4 t/ha netas en promedio. Las bandejas de siembra de tamaño G y D1 resultaron más apropiados para la producción de espárrago ya que permitieron obtener el mayor rendimiento en peso y número, y obtener un mejor aparato radical.

  20. Balance hídrico del suelo en pinares con diferente densidad de arbolado. Efectos sobre el establecimiento de brinzales de especies rebrotadoras bajo el dosel

    OpenAIRE

    Chirino Miranda, Esteban; Heredia-Osorio, Miriam; Granados, María Elena; Vilagrosa Carmona, Alberto; Manrique-Alba, Ángela; Ruiz-Yanetti, Samantha; Andarcio, Carlos; Bellot Abad, Juan Francisco

    2015-01-01

    El objetivo del presente trabajo fue determinar el balance hídrico del suelo en bosques de pino carrasco con diferente densidad de arbolado utilizando el modelo ecohidrológico HYDROBAL, y evaluar sus efectos sobre la introducción y establecimiento bajo el dosel, de brinzales de especies ampliamente utilizadas en la restauración forestal. En este contexto, en La Hunde (Ayora, Valencia), y como consecuencia de previas labores de aclareo con diferente intensidad, se definieron tres tratamientos ...

  1. Influencia de algunas variables climatológicas sobre las densidades larvarias en criaderos de Culícidos. Pol Cap. Roberto Fleites 2009-2010.

    Directory of Open Access Journals (Sweden)

    Dr. Sifredo García Gutiérrez

    2012-05-01

    Full Text Available ResumenLa Malaria es un problema de salud frecuente en países tropicales.1 Por ello realizamos esta investigación con el objetivo de determinar la presencia, distribución espacio-temporal y la densidad larval del mosquito Anopheles albimanus en criaderos permanentes en relación con algunas variables climatológicas en el Área de Salud Capitán Roberto Fleites de Santa Clara en los años 2009-2010.

  2. Densidad ósea y frecuencias de hallazgos en restos humanos en el Norte de Tierra del Fuego: Análisis exploratorio

    OpenAIRE

    Suby, Jorge A.; Ricardo A. Guichón

    2004-01-01

    La disponibilidad del registro biológico humano para su estudio está condicionada por procesos paleoecológicos y tafonómicos. Vinculado con esta problemática interesa explorar la relación entre Densidad Mineral Ósea (DMO) y frecuencias relativas de restos óseos humanos en el norte de Tierra del Fuego. La determinación de DMO ha sido poco empleada para el estudio de restos óseos humanos arqueológicos. Se contrastó la información densitométrica de restos provenientes del sitio Las Mandíbulas (T...

  3. Evaluación forestal y de combustiblesen bosques de Pinus hartwegiien el Estado de México según densidades de cobertura y vulnerabilidad a incendios

    OpenAIRE

    Mario Fermin Castañeda Rojas; Angel Rolando Endara Agramont; María de Lourdes Villers Ruiz; Eufemio Gabino Nava Bernal

    2015-01-01

    En el presente estudio se hace una evaluación forestal asociada a la cantidad y calidad de combustibles muertos en bosques de P. hart-wegii para señalar condiciones de vulnerabilidad y propensión a incendios. Con interpretación de imágenes de satélite multiespectrales del 2010, se determinaron tres densidades de cobertura para 23 685 ha de bosque de P. hartwegii del Estado de México. Se realizó un inventario forestal, presencia de actividad humana, carga de combustibles y parámetros físicos e...

  4. Evolución del peso, densidad mineral ósea y metabolismo lipídico en el paciente trasplantado renal.

    OpenAIRE

    Fernández-Castillo, Rafael

    2015-01-01

    [ES]Tras el trasplante se producen una serie de alteraciones metabólicas que podrían llegar a poner en riesgo la supervivencia del injerto y comprometer seriamente el estado de salud del paciente trasplantado renal. Entre las complicaciones metabólicas mas importantes se encuentran las alteraciones del metabolismo mineral y óseo y las alteraciones del metabolismo lipídico. Este trabajo tiene como objetivo investigar la ganancia de peso, las modificaciones en la densidad mineral ósea y la hip...

  5. Seepage mitigation at TransAlta's Rundle intake No. 2

    Energy Technology Data Exchange (ETDEWEB)

    Sobkowicz, J.; Cullum-Kenyon, S. [Thurber Engineering Ltd., Calgary, AB (Canada); Szojka, A. [TransAlta Utilities Corp., Calgary, AB (Canada)

    2006-07-01

    As part of its spray system of power generation, TransAlta operates the Rundle power canal, forebay and powerhouse located near Canmore, Alberta. Two penstocks run from the Rundle forebay to the powerhouse. Ongoing seepage problems around the intake to Unit No. 2 have been a problem for TransAlta, causing recurrent sinkholes, unpredictable variations in piezometric levels within the dam, and seepage flows at its toe. In order to assess the cause of the seepage and make a decision to proceed with mitigation, TransAlta conducted more frequent monitoring of these parameters, several surveys along the dam, and monitoring of pore water temperatures. The mitigation involved construction of a grout curtain under and adjacent to the intake and was performed from the ground surface as well as from within the penstock. This work required shutting down the penstock to Unit No. 2, lowering the water level in the forebay, and de-rating flow to Unit No. 1. This paper presented a brief history of the facility contributing to the cause of the seepage and the monitoring undertaken to assess its extent and seriousness. It also discussed the design and progress of the grouting program, including the response of the geotechnical instrumentation to the drilling and grouting process. Last, in order to evaluate the effectiveness of the remedial work, the post-grouting monitoring was examined. Comments were made on the usefulness of the various monitoring instruments and techniques used to determine dam performance prior to, during and after the grouting work. 1 ref., 9 figs.

  6. Plan de alta para personas con enfermedad pulmonar obstructiva crónica

    Directory of Open Access Journals (Sweden)

    Luz Marina Céspedes Salgado

    2006-01-01

    Full Text Available El plan de alta busca asegurar unos cuidados acordes con las necesidades y los requerimientos de la persona una vez egresa de la institución de salud, y debe constituirse en una guía básica en especial para la atención de aquéllos con patologías crónicas, como es la enfermedad pulmonar obstructiva crónica, que por su complejidad demanda múltiples cuidados para asegurar una intervención integral con miras al logro de una mejor adaptación, a identificar posibles complicaciones y a mejorar su calidad de vida. La experiencia de haber asumido el rol de hija y enfermera de un padre con enfermedad pulmonar obstructiva crónica (EPOC, y la alta incidencia de esta enfermedad, motivaron la elaboración de este plan de alta; fueron muchos los cuidados y muchas las necesidades y los cuestionamientos que se daban día a día, desde asegurar una adecuada comunicación hasta un conocimiento de los signos y síntomas de urgencia que indicaban una exacerbación, del uso adecuado de los medicamentos, de la importancia de la oxigenoterapia a largo plazo, de proporcionarle una dieta acorde con las recomendaciones y un ambiente favorable para sus condiciones de salud para, en últimas, alcanzar un entorno armónico, físico, familiar y espiritual.

  7. Densidad de población de pequeños mamíferos en dos comunidades del bosque Andino Densidad de población de pequeños mamíferos en dos comunidades del bosque Andino

    Directory of Open Access Journals (Sweden)

    Rodríguez Jane Rose

    1988-06-01

    Full Text Available

    The density of small mammals living in two communities of the Andean Forest of the eastern slopes of the Sabana de Bogota in the western Cordillera (Cerro Cueva Grande and Cerro Majuy, was studied. The two places were tramped for six months between March and September 1981, using livetraps and snaptraps during six days per month in each community. Densities for each species were obtained by the Hayne Melbod, the Lincoin and Jolly Indexes and by absolute density. Flora, climate and soil characteristics and their influence in the species were also considered in the two communities.

    Se estudió la densidad de población de pequeños mamíferos en dos comunidades de Bosque Andino, Cerro Cueva Grande, en el flanco occidental de la Sabana de Bogotá y Cerro Majuy, en la Sabana, localizadas sobre la Cordillera Oriental. Los dos sitios fueron trampeados en un periodo de seis meses desde marzo hasta septiembre del año 1981, uti1izando trampas para captura de animales vivos y trampas de golpe durante seis días por mes en cada comunidad. Se obtuvieron densidades para cada especie por el método de Hayne, y los índices de Lincoln, de Jolly y de densidad absoluta. Se tuvieron en cuenta las características de flora, clima y suelo para las dos comunidades y la manera como influye en las especies estudiadas.

  8. El ferulado con caños de polietileno de baja densidad PBDE para agua en la reparación de las fracturas acrales

    OpenAIRE

    Baraboglia, E. R.

    2010-01-01

    ResumenDesde el principio de los tiempos se le ha presentado al hombre el problema de las fracturas traumáticas y es de imaginar que tal vez en tan o más alta proporción que ahora, dado el sistema rudo en que les tocaba vivir.

  9. Determinación de aminas aromaticas por cromatografia liquida de alta resolución.

    OpenAIRE

    Gutiérrez Bouzán, Mª Carmen; Crespi Rosell, Martin

    1989-01-01

    Este trabajo consiste en la puesta a punto del metodo analítico para la determinación por cromatografia liquida de alta resolución (HPLC) de las aminas aromáticas empleadas más frecuentemente en la fabricación de colorantes sulfurosos: m-tolilendiamina, p-fenilendiamina, o-toluidina, p-toluidina, anilina, p-aminofenol, difenilamina, y p-hidroxidifenilamina. La longitud de onda de detección es de 260 nm. El principal objetivo del presente estudio es la consecución de un método de análisis p...

  10. Estudio del comportamiento en flexocompresión de los hormigones de alta resistencia

    OpenAIRE

    Arenas de Pablo, Juan José; Gutiérrez Martín, Germán; Vicente Cabrera, Miguel Ángel; González Cabrera, Dorys Carmen

    2004-01-01

    RESUMEN. Este artículo describe la máquina de ensayo desarrollada en el Laboratorio de Estructuras de la Universidad de Cantabria para obtener experimentalmente la distribución de tensiones en hormigones de diferentes resistencias, desde hormigones convencionales hasta hormigones de alta resistencia. Utilizando la máquina de ensayo anteriormente mencionada han sido ensayadas 240 probetas bajo carga creciente y excéntrica hasta rotura. Las variables de ensayo han sido la forma de la probeta, e...

  11. El entrenamiento interválico de alta intensidad para el rendimiento deportivo

    OpenAIRE

    Alvarez Fernández, Iker

    2014-01-01

    El entrenamiento interválico de alta intensidad (HIIT) ha sido una parte más de los programas de entrenamiento para mejorar el rendimiento deportivo, pero su efecto puntual en los entrenamientos de deportistas altamente entrenados no se conoce en su totalidad, a pesar de ser un elemento importante de la preparación deportiva. En esta revisión veremos cómo diversas investigaciones demuestran los diferentes efectos y adaptaciones que provoca el HIIT en estos deportistas con el fin de la mejora ...

  12. Efeito de alta pressão no processo de demolha de bacalhau

    OpenAIRE

    Salvador, Ângelo Miguel Correia

    2009-01-01

    Este trabalho experimental teve como objectivo recorrer à tecnologia de alta pressão hidrostática com o intuito de acelerar o processo de demolha de bacalhau, em termos de saída de sal e entrada de água. Inicialmente tentou-se desenvolver uma metodologia rápida para quantificação do NaCl mediante condutivimetria. Contudo, como se verificaram diferenças entre os resultados obtidos por este método e o método químico usado neste trabalho, a quantificação do sal por condutivimet...

  13. Neurodesarrollo en egresados de la terapia intensiva neonatal a los 6 meses del alta hospitalaria

    OpenAIRE

    Dayami Armas-Guerra; Tania Mejías-Martín; Ana Nastia Tamayo-Ortiz; María Caridad Jardines-Carballosa

    2012-01-01

    Se abordó estudio descriptivo longitudinal de 16 recién nacidos egresados del servicio de Neonatología del Hospital Pediátrico de Holguín, desde febrero a junio del 2009. Se les evaluó desde el punto de vista neurológico a los seis meses del alta hospitalaria. Un 25% presentaron anormalidad del examen neurológico. Las alteraciones leves y moderadas se comportaron igual. El sexo femenino fue el más afectado, la menor edad gestacional y el peso menor de 1500 gramos predispusieron a la aparición...

  14. Factores de riesgo, asociados a intento de suicidio, comparando factores de alta y baja letalidad

    OpenAIRE

    Garcia Rabago, Horacio; Sahagun Flores, Jose Ernesto; Ruiz Gomez, Alfonso; Sanchez Ureña, Gustavo Manuel; Tirado Vargas, Juan Carlos; Gonzalez Gamez, Jaime Guillermo

    2012-01-01

    Objetivo El propósito del estudio fue Identificar los factores de riesgo más frecuentes asociados a intento de suicidio para determinar si existen diferencias entre los factores de riesgo presentes en pacientes con tentativa de baja letalidad y los de alta letalidad. Método Se entrevistaron 106 pacientes de ambos sexos, con diagnóstico de intento de suicidio, hospitalizados en una unidad psiquiátrica, divididos en dos grupos: uno pacientes con tentativa suicida de baja letalidad y otro con te...

  15. Contribución al modelado unidimensional en motores de dos tiempos de altas prestaciones

    OpenAIRE

    JIMENEZ MACEDO, VICTOR DANIEL

    2013-01-01

    Un modelo de simulación presenta muchas ventajas en el campo del desarrollo de motores de combustión interna alternativos. Su utilidad es doble. Por un lado, para entender la naturaleza de los fenómenos físicos que suceden en el interior del motor, y por otro, con el fin de optimizar el diseño de los sistemas que integran el mismo. El principal objetivo de esta tesis es desarrollar un modelo de un motor de dos tiempos de 125 cc de altas prestaciones para caracterizar la fluidodinámica interna...

  16. Diseño de sistemas WIFI en trenes de alta velocidad

    OpenAIRE

    Alonso Barbero, Carlos

    2015-01-01

    En este Trabajo Fin de Grado se realiza el diseño de un sistema que proporcione acceso a internet a los usuarios en un tren de alta velocidad. Se busca conseguir un sistema inalámbrico (WIFI) que permita un gran número de conexiones simultáneas con un ancho de banda suficiente para todas ellas. En este proyecto se buscará una tecnología capaz de cumplir estos requisitos, realizando un estudio de las tecnologías disponibles actualmente (WiMAX, satélite, 3G/4G). Las diferentes tecnologías pr...

  17. La identificación de alumnos con altas habilidades: enfoques y dimensiones actuales

    OpenAIRE

    Rojo Martínez, Angela

    1996-01-01

    La tesis ha quedado estructurada en dos partes. En la primera, se desarrolla y fundamenta el marco teórico de este trabajo de investigación, desde el que se presentan los principales planteamientos conceptuales que han ayudado y están contribuyendo a definir la alta habilidad intelectual, haciendo especial hincapié en enfoques amplios y variados, que permitan que la identificación de esos sujetos se realice considerando junto a su potencial intelectual otras muchas y diferentes variables. Y l...

  18. CARCINOMA BRONQUÍOLO-ALVEOLAR: ASPECTOS NA TOMOGRAFIA COMPUTADORIZADA DE ALTA RESOLUÇÃO

    OpenAIRE

    Moreira Luiza Beatriz Melo; Marchiori Edson; Melo Alessandro Severo Alves de; Magnago Marcelo; Muniz Maria Angélica Soares; Irion Klaus

    2002-01-01

    O carcinoma bronquíolo-alveolar é um tipo de carcinoma broncogênico de crescimento insidioso, que surge nas paredes das vias aéreas distais e se dissemina utilizando o septo alveolar como um estroma, preservando a arquitetura pulmonar. Neste trabalho foram analisadas as tomografias computadorizadas de alta resolução de 17 pacientes com carcinoma bronquíolo-alveolar. Ao contrário do relatado na literatura, foram observados predomínio no sexo masculino (71%) e maior freqüência da associação das...

  19. Simulación de altas prestaciones para modelos orientados al individuo

    OpenAIRE

    Mostaccio, Diego Javier

    2007-01-01

    Existen diversos campos de la biología que necesitan realizar experimentos para estudiar el modelo de comportamiento de diferentes especies. En la presente tesis, se analizan las diferentes posibilidades de análisis en base a sistemas de simulación de altas prestaciones donde se ha desarrollado un laboratorio virtual que permite a los científicos experimentar con sus modelos y realizar pruebas mediante métodos de simulación distribuida. El modelo utilizado es un Modelo Orientado al Individuo ...

  20. ESTUDIO DE ALUMNOS DE EDUCACIÓN SECUNDARIA OBLIGATORIA CON ALTAS CAPACIDADES INTELECTUALES

    OpenAIRE

    Anda-Moreno, Verónica

    2012-01-01

    El presente Trabajo de Fin de Máster realizado para la obtención del título del Máster en Formación de Profesorado de Educación Secundaria Obligatoria, Bachillerato, Formación Profesional y Enseñanza de Idiomas, Especialidad en Física y Química, de la Universidad Internacional de La Rioja trata del estudio de Alumnos con Altas Capacidades Intelectuales de la Educación Secundaria Obligatoria del sistema educativo español. En el entorno escolar, siempre se han presentado casos de niños...

  1. Herramientas TIC para la intervención educativa en estudiantes con altas capacidades

    OpenAIRE

    Tárraga Mínguez, Raúl; Sanz-Cervera, Pilar; Pastor Cerezuela, Gemma; Fernández Andrés, María Inmaculada

    2014-01-01

    Los estudiantes con altas capacidades procesan la información de manera distinta, ya que estos poseen una elevada creatividad e implicación en la tarea. Este hecho implica la necesidad de llevar acabo una intervención educativa específica. Algunos modelos teóricos han demostrado la efectividad del uso de las TICs en la intervención de este tipo de alumnado, por lo que en el presente artículo se incluyen diferentes herramientas TIC que pueden ser de gran utilidad para los docentes. Entre estas...

  2. Altas capacidades. Propuesta de intervención para el aprendizaje de la historia

    OpenAIRE

    Gárriz Forné, Javier

    2013-01-01

    El presente estudio de carácter teórico, es una aproximación al conocimiento de las necesidades educativas del alumnado con altas capacidades intelectuales y pretende desarrollar una propuesta educativa que responda a esas necesidades, desde las ciencias sociales, concretamente desde la historia. Partiendo de la legislación vigente y teniendo en cuenta el planteamiento de algunos autores que abordan esta problemática, primero, comenzaré perfilando las características de este alumnado; pos...

  3. Alumnado con altas capacidades intelectuales: Programa de intervención

    OpenAIRE

    Arranz Melado, Luis Alfonso

    2015-01-01

    En el presente trabajo se hace un breve resumen conceptual de la literatura científica sobre las altas capacidades intelectuales. Se hace referencia a conceptos, teorías y modelos. Luego se analiza algunas de las características del alumnado con necesidades educativas especiales. Seguidamente, se hace referencia a los procedimientos y técnicas de evaluación de los estudiantes con necesidades educativas especiales. Se hace mención de las diferentes modalidades de respuesta educativa aplica...

  4. Procesos de automatización cognitiva en alumnado con altas capacidades intelectuales

    OpenAIRE

    Juan Montero-Linares; José I. Navarro-Guzmán; Manuel Aguilar-Villagrán

    2013-01-01

    Proponemos desde el enfoque del procesamiento de la información, el estudio de características cognitivas que faciliten la identificación de las altas capacidades. A tal fin, elaboramos una tarea de habilidad de segmentación silábica que, a partir del modelo propuesto por Baddeley sobre la memoria de trabajo y la distinción entre procesos automáticos y controlados, nos permitiese comprobar las diferencias en cuanto a la capacidad de automatización de la información y si los indicadores propue...

  5. Alumnos con altas capacidades intelectuales: Propuesta de Intervención

    OpenAIRE

    Cano-Aguirre, María Isabel

    2012-01-01

    En este trabajo se ha realizado una revisión bibliográfica acerca de las características de los alumnos de altas capacidades intelectuales, su funcionamiento cerebral y los proyectos que se aplican en la actualidad. En la segunda parte se ha realizado una investigación con un enfoque cualitativo en la cual se proporcionó un cuestionario a un grupo de profesionales que participan en proyectos dirigidos a este tipo de alumnado con el fin de detectar la situación actual en la que se encuentran. ...

  6. Género, adolescencia y altas capacidades : un acercamiento a la afectividad

    OpenAIRE

    González González, Leybiz

    2012-01-01

    El presente estudio fue realizado en un grupo de chicas y chicos adolescentes pertenecientes a la Asociación Onubense de Altas Capacidades ARETÉ. Sus propósitos consistieron en analizar el aspecto afectivo-relacional a través de una perspectiva de género, en la que fueron identificadas las vivencias y áreas de conflictos psicológicos, las preocupaciones, temores, satisfacciones e insatisfacciones presentes. Asimismo, se pretendió develar algunos elementos de la conformación de ...

  7. La evaluación psicopedagógica del alumnado con altas capacidades intelectuales

    OpenAIRE

    Moliner García, Odet; Comes Nolla, Gabriel; Luque, Antonio; Díaz Pareja, Elena María

    2008-01-01

    Tras un análisis de la normativa estatal y autonómica sobre la evaluación psicopedagógica del alumnado con altas capacidades intelectuales, se presentan los aspectos más relevantes que toda evaluación psicopedagógica debe contemplar para que resulte lo más eficaz posible, y permita ofrecer una respuesta educativa adecuada a dicho alumnado e identifique los recursos y apoyos que pueda precisar. Tales decisiones se concretan en el informe psicopedagógico y este artículo recoge...

  8. Alumnos con indicios de altas capacidades en Educación Infantil

    OpenAIRE

    López-Gómez, Sheila

    2012-01-01

    En las aulas se encuentran niños de altas capacidades que no han sido diagnosticados y por lo tanto no se está atendiendo a sus necesidades como se debiera. Mediante este trabajo de fin de grado se ha pretendido señalar las características principales que permiten al tutor del aula reconocer a estos alumnos y poderles derivar a los orientadores que señalarán las pautas necesarias para conseguir que el alumno se desarrolle en plenitud y se sienta integrado en el aula. Para ello se van a exp...

  9. Resultados del relevamiento de HI en el Cielo Austral: 3. Relevamiento de Nubes de Alta Velocidad

    Science.gov (United States)

    Morras, R.; Bajaja, E.; Arnal, E. M.; Pöppel, W. G. L.

    Los resultados del relevamiento de HI del Hemisferio Austral fueron reprocesados con el fin de incrementar su sensibilidad. Así, se utilizó esta nueva base de datos con el fin de obtener un nuevo relevamiento de Nubes de Alta Velocidad en el cielo austral. El ruido r.m.s. alcanzado es de 0.015-0.020 K, con una resolución espectral de 8 km/seg. El cubrimiento espacial del relevamiento mejora en un factor 16 al realizado por Bajaja et al (1985).

  10. Alta hospitalar do recém-nascido prematuro: experiência do pai

    OpenAIRE

    Bruna de Souza Lima Marski; Natália Custodio; Flávia Corrêa Porto de Abreu; Débora Falleiros de Melo; Monika Wernet

    2016-01-01

    RESUMO Objetivo: descrever a experiência do pai frente à alta do filho prematuro da Unidade de Terapia Intensiva Neonatal e apontar intervenções para a promoção dessa experiência. Método: pesquisa qualitativa com oito pais que adotou o Interacionismo Simbólico como referencial teórico e a pesquisa de narrativa temática como referencial metodológico. Resultados: a análise dos dados permitiu descrever a experiência do pai a partir de três unidades temáticas: 'limites para a paternidade', 'al...

  11. USO DE IMÁGENES SATELITALES DE ALTA RESOLUCIÓN PARA GENERAR CARTOGRAFÍA

    OpenAIRE

    Patricio Zavala; Carlos Zavala

    2002-01-01

    Se presenta la metodología aplicada en la ciudad de Arica, Norte de Chile, para generar cartografía de altura de construcciones, mediante el análisis digital de una imagen satelital de alta resolución. Para ello, nos basamos en el cálculo de la longitud de las sombras que se derivan de distintas edificaciones, y del azimut solar de una imagen IRS 1C, que fue remuestreada mediante convolución cúbica a 5 metros. Este trabajo está basado fundamentalmente en los logros alcanzados en el desarrollo...

  12. SAÓ, sistema de ayuda ortoépica para la lectura en voz alta del valenciano

    OpenAIRE

    Forcada, Mikel L.; Beltran i Calvo, Vicent; Segura i Llopes, Carles; Colomina i Castanyer, Jordi

    2003-01-01

    Este proyecto se propone elaborar un programa informático que ayudará a los locutores de radio y televisión y, en general, a cualquier persona, a leer el valenciano correctamente en voz alta. El sistema resultante, denominado SAÓ (sistema de ayuda ortoépica), anotará automáticamente el texto con marcas sencillas que indicarán la pronunciación correcta en algunos casos difíciles, usando un ordenador de sobremesa común. En particular, podrá ser usado para enseñar l...

  13. Impacto de la regulación ambiental en las actividades de la alta gerencia corporativa

    OpenAIRE

    Rina Tigrera Carneiro

    2003-01-01

    El presente ensayo tiene por finalidad exponer algunas consideraciones y reflexiones acerca del impacto que ha generado la regulación ambiental en las actividades de la alta gerencia corporativa. Para tal fin, fue necesario realizar una revisión documental de las distintas bibliografías, documentos y escritos especializados en el área, tanto en el ámbito nacional como latinoamericano; la cual, permitió llegar a las siguientes conclusiones: la introducción de las distintas regulaciones de índo...

  14. Computación de altas prestaciones ecológica

    OpenAIRE

    González, Lucía; Uribe, Federico; Balladini, Javier; Sánchez, Laura

    2011-01-01

    La computación de altas prestaciones ha tenido, por décadas, el único objetivo de incrementar la velocidad de procesamiento de las aplicaciones computacionalmente complejas. Dado el tamaño actual de las supercomputadoras, el consumo energético de las mismas es tan elevado que producen un tremendo impacto económico. Además, la falta de explotaci ón de las energías renovables y limpias hacen que la producción energética afecte signi- cativamente en lo ecológico y social. Estos factores nos ...

  15. Caracterizando a los consumidores en los mercados de consumo de alta frecuencia

    OpenAIRE

    Juan Carlos Gáquez Abab; Manuel Sánchez Pérez

    2007-01-01

    Los mercados de consumo de alta frecuencia presentan rasgos particulares en cuanto a la diversidad de estrategias de precio, constantes promociones en precio, publicidad masiva o estrategias de marca que hacen que la identificación de segmentos sea especialmente interesante para la empresa. En el presente trabajo se lleva a cabo un análisis de segmentación sobre datos de panel que pretende identificar cuántos segmentos existen y describir cuál es su comportamiento en relación a...

  16. Densidade e diversidade fenotípica de bactérias diazotróficas endofíticas em solos de mineração de bauxita, em reabilitação Density and phenotypic diversity of endophytic nitrogen fixing bacteria in soils under rehabilitation after bauxite mining

    Directory of Open Access Journals (Sweden)

    R. Melloni

    2004-02-01

    Full Text Available Bactérias diazotróficas endofíticas contribuem para o desenvolvimento das plantas por meio da fixação biológica do nitrogênio, produção e liberação de substâncias reguladoras do crescimento vegetal, podendo, assim, facilitar a revegetação de solos degradados por atividades antrópicas. No entanto, pouco se conhece sobre as populações destas bactérias em solos ou plantas de áreas de mineração. Objetivando avaliar o efeito de diferentes tipos de vegetação e tempo de reabilitação de áreas degradadas por mineração de bauxita na densidade e diversidade de algumas espécies de bactérias diazotróficas endofíticas, realizaram-se, em duas épocas, amostragens de solo, de dois ambientes distintos, submetidos a diferentes processos de reabilitação. A densidade, avaliada pelo número mais provável, utilizando os meios de cultura: NFb, JNFb e Fam, para Azospirillum brasilense e A. lipoferum, Herbaspirillum spp. e A. amazonense, respectivamente, variou de 0 a 2,0 x 10(4 bactérias por grama de solo e mostrou que o tipo de vegetação influiu nas populações destas bactérias. Foram encontradas densidades maiores em solos revegetados com gramíneas: braquiária (Brachiaria decumbens, capim-azevém (Lolium multiflorum e capim-gordura (Melinis minutiflora. Contudo, estas densidades podem ser consideradas baixas, se comparadas às de solos agrícolas, e não apresentaram relação com o tempo de reabilitação da área. Foram encontrados 36 fenótipos culturais em meio batata, entre os 72 isolados obtidos dos três meios de cultura utilizados. A partir destes, foram formados sete grandes grupos com similaridade superior ou igual a 63 %, dos quais cinco, representando 62,5 % do total de isolados obtidos, continham as estirpes-tipo de Burkholderia brasilensis, Herbaspirillum seropedicae e Azospirillum spp. (A. brasilense, A. amazonense, A. lipoferum, A. irakense. Apesar da baixa densidade, este grupo de bactérias apresentou alta

  17. Estimación de la densidad poblacional del venado cola blanca texano (odocoileus virginianus texanus, introducido en la UMA "Ejido de Amanalco" Estado de México

    Directory of Open Access Journals (Sweden)

    Claudia Yanira Beltrán Vera

    2010-01-01

    Full Text Available La introducción del O.v. texanus en Amanalco, Estado de México, ocurrió en el año 2000 con diez ejemplares y para estimar la densidad poblacional actual se utilizó el método indirecto; realizándose 13 transectos lineales con un área promedio de muestreo de 26 400 m2 para cada uno, utilizando la fórmula de Eberhardt y Van Etten (1956. Con cuatro repeticiones distribuidas en verano e invierno. Se observó una densidad de 0.4216 y 0.5238 venados/ha respectivamente que corresponde a la distribución natural de la subespecie (O.v mexicanus, siendo la especie más vulnerable de las 14 que se encuentran en nuestro país. Se concluye que la introducción de una subespecie exótica y su establecimiento exitoso, representa un riesgo latente de hibridación con la especie nativa.

  18. Modelo de cálculo de áreas verdes en planificación urbana desde la densidad habitacional

    Directory of Open Access Journals (Sweden)

    Francisco Bascuñán Walker

    2015-03-01

    Full Text Available El objetivo del trabajo presentado fue reformular la relación de área construida y área verde Chilena según los estándares internacionales Europeos. Se estudio la mecánica actual de determinación de superficie de área verde en Chile y se comparó con los estándares españoles, elaborando una nueva formula que relaciona directamente la densidad habitacional con la superficie de área verde requerida. El estudio mostró que los resultados de superficies de área verde son de tal envergadura que requieren asociarse a parques comunales e intercomunales. Basados en los resultados del estudio se concluye que para cumplir con las superficies requeridas según la densidad habitacional los loteos nuevos deben contemplar su participación en proyectos de parques urbanos o comunales para garantizar el derecho de áreas verdes de los nuevos habitantes.

  19. TRANSICIÓN DE FASE ENTRE FORMAS FCC Y BCC DEL ESTRONCIO Y SUS PROPIEDADES ESTRUCTURALES Y ELECTRONICAS MEDIANTE TEORÍA DEL FUNCIONAL DE LA DENSIDAD (DFT

    Directory of Open Access Journals (Sweden)

    María A. Puerto

    2012-01-01

    Full Text Available Se han realizado cálculos de primeros principios para de terminar las propiedades estructurales y electrónicas del estroncio en sus fases de cristalización Im-3m y Fm-3m dentro del formalismo de la Teoría del Funcional de la Densidad (DFT. Esto se hizo a partir del método de ondas planas aumentadas y linealizadas en la versión de potencial completo (FP-LAPW con la aproximación de gradiente generalizado (GGA. Se encontró que la configuración más estable es la Fm-3m , con una constante de red a 0 = 11,38 bohr , energía de cohesión E o = - 0,107 Ry y módulo de volumen B 0 = 113 GPa . A partir de la densidad de esta dos y la estructura de bandas de energía se evidenció el carácter metálico de este elemento para ambas estructuras cristalinas. Se predice una posible transición de fase estructural de la Fm-3m a la Im-3m bajo una presión de 178 GPa .

  20. Antiproteinuric therapy decreases LDL-cholesterol as well as HDL-cholesterol in non-diabetic proteinuric patients: relationships with cholesteryl ester transfer protein mass and adiponectin

    NARCIS (Netherlands)

    J.A. Krikken; F. Waanders; G.M. Dallinga-Thie; L.D. Dikkeschei; L. Vogt; G.J. Navis; R.P.F. Dullaart

    2009-01-01

    Objective: Dyslipidemia contributes to increased cardiovascular risk in nephrotic syndrome. We questioned whether reduction in proteinuria not only lowers low-density lipoprotein cholesterol (LDL-C), but also high-density lipoprotein cholesterol (HDL-C) and cholesteryl ester transfer protein (CETP)