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Sample records for alta densidad hdl

  1. Densidad de desarrollo alta y baja en Puerto Rico

    Science.gov (United States)

    William A. Gould; Sebastian Martinuzzi; Olga M. Ramos Gonzalez

    2008-01-01

    Este mapa demuestra la distribución de terrenos de alta y baja densidad de desarrollo urbano en Puerto Rico (Martinuzzi et al. 2007). El mapa fue creado mediante el analisis de un mosaico de imagenes de satelite Landsat ETM+ de los años 2000 – 2003. La clasificacion no supervisada ISODATA (“Iterative Self-Organizing Data Analysis Technique”) (ERDAS 2003) fue utilizada...

  2. Cultivo de cachama blanca en altas densidades y en dos sistemas cerrados

    Directory of Open Access Journals (Sweden)

    Germán Poleo

    2011-04-01

    Full Text Available El objetivo de este trabajo fue evaluar la tolerancia de la cachama blanca, Piaractus brachypomus, a cultivos en altas densidades en sistemas cerrados. Novecientos alevines de 44,3±26 g de peso, se distribuyeron en seis tanques de concreto, con 4,8 m³ de agua. Tres tanques presentaron cero recambio de agua (SCR, y en otros tres, el agua se hizo circular a través de un bioclarificador (SRA. Ambos tratamientos presentaron fuerte aireación para mantener los sólidos en suspensión y suministrar aire. Los peces se alimentaron a saciedad con pienso comercial por 192 días. Los parámetros de calidad de agua como: oxígeno disuelto, amonio total, nitritos, nitratos, alcalinidad, dureza, temperatura y pH, se midieron semanalmente. Los peces en el SCR crecieron a una tasa de 2,34±0,05 g por día, y tuvieron conversión alimenticia de 1,5±0,06, densidad final de 12,96±0,53 kg m-3, y peso final de 449,5±99 g. En el SRA, los peces crecieron 2,33±0,03 g por día, con conversión alimenticia de 1,6±0,07, densidad final de 12,13±1,12 kg m-3, y peso final de 446,5±10 g. La cachama blanca puede ser cultivada en sistemas cerrados con cero recambio de agua en altas densidades.

  3. Cultivo de cachama blanca en altas densidades y en dos sistemas cerrados

    OpenAIRE

    Poleo, Germán; Aranbarrio, José Vicente; Mendoza, Lismen; Romero, Oneida

    2011-01-01

    El objetivo de este trabajo fue evaluar la tolerancia de la cachama blanca, Piaractus brachypomus, a cultivos en altas densidades en sistemas cerrados. Novecientos alevines de 44,3±26 g de peso, se distribuyeron en seis tanques de concreto, con 4,8 m³ de agua. Tres tanques presentaron cero recambio de agua (SCR), y en otros tres, el agua se hizo circular a través de un bioclarificador (SRA). Ambos tratamientos presentaron fuerte aireación para mantener los sólidos en suspensión y suministrar ...

  4. LEVITACIÓN MAGNÉTICA EN FLUIDOS DE ALTA VISCOSIDAD Y DENSIDAD

    OpenAIRE

    ELIANA RONDÓN; JULIO CARRILLO; RODRIGO CORREA

    2010-01-01

    Este artículo describe el diseño de un sistema prototipo de levitador magnético que opera sumergido en un aceite dieléctrico de viscosidad y densidad sustancialmente superior a la del aire. Se implementó un compensador de atraso de fase en cascada con la planta con el fin de posicionar un cascaron esférico metálico en un punto en particular dentro del aceite. Se analizó el comportamiento del sistema al variar la viscosidad mediante la variación de la temperatura del fluido, observándose que a...

  5. Nanocompósitos poliméricos de polietileno de alta densidade contendo hidróxidos duplos lamelares intercalados com ânions derivados de corantes azo

    OpenAIRE

    Zimmermann, Ademir; Jaerger, Silvia; Wypych, Fernando; Zawadzki, Sonia Faria

    2014-01-01

    O presente trabalho descreve a síntese e caracterização de hidróxidos duplos lamelares (HDL) de Zn/Al na razão molar 2:1, os quais foram intercalados com íons cloreto hidratados e ânions derivados dos corantes azo alaranjado de metila (AM) e alaranjado II (AII). Após caracterização, os materiais foram utilizados como cargas em polietileno de alta densidade (PEAD) e nanocompósitos foram preparados por extrusão e injeção, seguindo a norma ASTM D638-10. Os teores de cargas variaram de 0,1 até 2%...

  6. LEVITACIÓN MAGNÉTICA EN FLUIDOS DE ALTA VISCOSIDAD Y DENSIDAD

    Directory of Open Access Journals (Sweden)

    ELIANA RONDÓN

    2010-01-01

    Full Text Available Este artículo describe el diseño de un sistema prototipo de levitador magnético que opera sumergido en un aceite dieléctrico de viscosidad y densidad sustancialmente superior a la del aire. Se implementó un compensador de atraso de fase en cascada con la planta con el fin de posicionar un cascaron esférico metálico en un punto en particular dentro del aceite. Se analizó el comportamiento del sistema al variar la viscosidad mediante la variación de la temperatura del fluido, observándose que a medida que su viscosidad disminuye con el aumento de temperatura, el sistema se torna inestable, mientras que para el caso del incremento de su viscosidad, el tiempo de respuesta se torna muy grande y el sistema responde lentamente. El sistema se simuló obteniéndose resultados que concuerdan estrechamente con los resultados del prototipo experimental que sirvió para validar el diseño.

  7. Propriedades mecânicas e análise térmica de resíduos de polietileno de alta densidade (PEAD) reciclado

    OpenAIRE

    Paola da Silva Richter Quintana Nunes

    2015-01-01

    Atualmente grande parte dos resíduos descartados rotineiramente no Brasil é composta por material plástico como, por exemplo, o polietileno de alta densidade (PEAD), o qual é muito comum no lixo doméstico. Nesta Dissertação, embalagens de PEAD pós-consumo foram coletadas e moídas. Após processamento em extrusora, o material definido como PEAD reciclado (mistura de embalagens brancas, marfins e incolores) foi injetado e as propriedades mecânicas foram avaliadas e comparadas com uma amostra de ...

  8. Preparación y caracterización de compuestos de Capirona-Polipropileno y Capirona-Polietileno de alta densidad

    OpenAIRE

    Gago, Javier; Ramos, Víctor; León, Kety; Solís, José; Acevedo, Moisés; López, Alcides

    2014-01-01

    Se presentan los resultados de la caracterización de compuestos madera-polímero, obtenidos a partir de residuos particulados de Capirona de 710 µm con polipropileno y polietileno de alta densidad. Estos han sido mezclados con anhídrido maléico y extruidos a una temperatura entre 150 y 180 ºC, obteniéndose pellets pequeños de forma cilíndrica. Posteriormente, los pelletes han sido prensados en forma de probetas y tratados térmicamente a 170 ºC. Algunas probetas han sido gamma-irradiadas con f...

  9. Viabilidade econômica de estocagem de alevinos de carpa comum (Cyprinus Carpio Var. Specularis no inverno em alta densidade

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    Graeff Álvaro

    2001-01-01

    Full Text Available O objetivo desta pesquisa foi estudar o efeito econômico de povoamento de alevinos I de carpa comum (Cyprinus carpio L., no inverno em alta densidade, com suplementação artificial e adubação química. O delineamento foi inteiramente casualizado com quatro tratamentos (5; 10; 15 e 20 peixes/m² e nove repetições. Os peixes foram estocados com peso e comprimento médios de 0,48 g e 3,15 cm, respectivamente, em todos tratamentos, por 45 dias de idade. As dietas foram formuladas com 27% de PB e 2925 kcal/kg de ração, sendo fornecidas diariamente, em duas vezes, na quantidade de 3% do peso vivo. O comportamento das variáveis explicativas em função dos tratamentos foi estudado por intermédio da análise de regressão. Os resultados para o comprimento e peso médio final nas densidades de 5; 10; 15 e 20 foram 8,67; 8,06; 7,81 e 7,47 cm e 3,64; 2,80; 2,31 e 2,25 g, respectivamente. O comportamento do peso em função das densidades estudadas é descrito pela equação de regressão quadrática Y= 4,41 - 0,29 X + 0,0077X² . O comportamento do comprimento e da conversão alimentar, em função das densidades, é explicado por regressão linear, por intermédio das equações Y= 5,83 - 0,077X e Y= 0,9978 + 0,0844X, respectivamente. A sobrevivência foi de 98,41; 97,61; 97,35 e 97,21%, respectivamente, nas densidades de 5 a 20. Em condições similares, pode-se recomendar todas as densidades estudadas e, economicamente, a lucratividade da atividade é crescente com o aumento da densidade, havendo diminuição do custo médio ou unitário.

  10. Densidad de ungulados en bosques de baja y alta presión de caza en el nororiente de la Amazonía peruana

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    Rolando Aquino

    2015-01-01

    Full Text Available Se proporciona información sobre tamaño de rebaño en pecaríes y densidad poblacional de éstos y otros ungulados para los bosques de baja y alta presión de caza del nororiente peruano. Durante el recorrido de 610 km de transecto de Noviembre-Diciembre 2012 en bosques de baja presión de caza y de 1218 km desde Febrero-Junio y Agosto-Octubre 2013 en bosques de alta presión de caza, fueron registrados 76 y 40 encuentros pertenecientes a seis y cinco especies, respectivamente; siendo los más comunes Pecari tajacu (35% y Mazama americana  (28%. El tamaño de rebaño en P. tajacu varió desde 2 a 8 individuos (tamaño promedio: 3,4±1,6 a 6±1,2. La densidad poblacional estimada para los ungulados fueron más altas en bosques de baja presión de caza sobresaliendo Tayassu pecari con 23,8 individuos/km2, seguido por P. tajacu con 14,4 individuos/km2, en tanto que la más baja fue para Tapirus terrestris (0,08 individuos/km2 y correspondió a los bosques de alta presión de caza. En los bosques de baja presión de caza, los encuentros más frecuentes con ungulados ocurrieron en el palmal de altura (46% y palmal de planicie (31%, en tanto que en el pantano arbóreo no hubo encuentros.

  11. Densidad de ungulados en bosques de baja y alta presión de caza en el nororiente de la Amazonía peruana

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    Rolando Aquino

    2014-12-01

    Full Text Available Se proporciona información sobre tamaño de rebaño en pecaríes y densidad poblacional de éstos y otros ungulados para los bosques de baja y alta presión de caza del nororiente peruano. Durante el recorrido de 610 km de transecto de noviembre-diciembre 2012 en bosques de baja presión de caza y de 1218 km desde febrero-junio y agosto-octubre 2013 en bosques de alta presión de caza, fueron registrados 76 y 40 encuentros pertenecientes a seis y cinco especies, respectivamente; siendo los más comunes Pecari tajacu (35% y Mazama americana (28%. El tamaño de rebaño en P. tajacu varió desde 2 a 8 individuos (tamaño promedio: 3,4±1,6 a 6±1,2. La densidad poblacional estimada para los ungulados fue más alta en bosques de baja presión de caza sobresaliendo Tayassu pecari con 23,8 individuos/km2, seguido por P. tajacu con 14,4 individuos/km2, en tanto que la más baja fue para Tapirus terrestris (0,08 individuos/km2 y correspondió a los bosques de alta presión de caza. En los bosques de baja presión de caza, los encuentros más frecuentes con ungulados ocurrieron en el palmal de altura (46% y palmal de planicie (31%, en tanto que en el pantano arbóreo no hubo encuentros.

  12. Nanocompósitos poliméricos de polietileno de alta densidade contendo hidróxidos duplos lamelares intercalados com ânions derivados de corantes azo

    Directory of Open Access Journals (Sweden)

    Ademir Zimmermann

    2014-06-01

    Full Text Available O presente trabalho descreve a síntese e caracterização de hidróxidos duplos lamelares (HDL de Zn/Al na razão molar 2:1, os quais foram intercalados com íons cloreto hidratados e ânions derivados dos corantes azo alaranjado de metila (AM e alaranjado II (AII. Após caracterização, os materiais foram utilizados como cargas em polietileno de alta densidade (PEAD e nanocompósitos foram preparados por extrusão e injeção, seguindo a norma ASTM D638-10. Os teores de cargas variaram de 0,1 até 2% (incluindo-se os sais de sódio dos corantes e os nanocompósitos homogêneos foram avaliados em relação as suas propriedades estruturais, térmicas e mecânicas. De modo geral, após a adição das cargas existe somente uma pequena influência na temperatura de fusão e cristalização do PEAD. Para os HDLs contendo o pigmento intercalado com o ânion do corante AM e sais de sódio de ambos os corantes, as propriedades mecânicas apresentaram leve aumento do módulo e tensão de ruptura e diminuição do alongamento em relação ao polímero puro e um comportamento inverso foi observado para o ânion AII, além do HDL contendo ânions cloreto hidratados.

  13. Soldabilidad de Polietileno de Alta Densidad Usando Soldadura por Fricción-agitación con una Herramienta de Hombro no Rotacional

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    Yorledis Macea Romero

    Full Text Available Resumen: En este trabajo se estudió la soldabilidad de polietileno de alta densidad (PEAD mediante el proceso de soldadura por fricción agitación (SFA, usando dos herramientas diferentes, una convencional y otra con hombro no rotacional, denominada no convencional. La evaluación comparativa fue realizada bajo combinaciones de los parámetros de velocidad de rotación (vW y velocidad de avance (vA ajustados para cada herramienta. La soldabilidad fue valorada con base en inspección visual, la presencia de discontinuidades mediante estereoscopia y microscopia confocal y la dureza en las juntas soldadas. Como resultado se obtuvo que la herramienta no convencional permitió obtener juntas soldadas libres de discontinuidades y con excelente apariencia externa gracias al menor calor aportado. La dureza en la zona agitada fue menor a la del material base, mostrando comportamientos diferenciados en los lados de avance y retroceso en función de los parámetros de proceso.

  14. Monitoreo de cambios en la densidad de cobertura forestal en bosque templado usando fotografías aéreas digitales de alta resolución

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    José López García

    2016-08-01

    Full Text Available Se utilizaron series multitemporales de fotografías aéreas digitales de alta resolución de pequeño formato para evaluar los cambios en la densidad de cobertura forestal en un bosque templado. Una combinación de técnicas convencionales y adaptadas de fotogrametría y fotointerpretación fueron utilizadas para establecer un método específico de evaluación.  Este método ha sido probado en un periodo de doce años (1999-2011 en la zona núcleo de la Reserva de la Biósfera Mariposa Monarca, localizada en los estados de México y Michoacán, en México, usando mosaicos ortorectificados como mapas base para evaluar cambios bienales. Las imágenes fueron fotointerpretadas de manera tradicional marcando los cambios sobre acetatos, colocados sobre las imágenes impresas, creando así nuevos polígonos. Estos fueron transferidos directamente de los acetatos al ortomosaico a través de la pantalla de la computadora, usando al menos tres puntos de control, cumpliendo así con el principio de triangulación radial. El bosque fue separado en las siguientes clases de cobertura forestal: cerrada, semi-cerrada, semi-abierta, abierta y deforestada. La evaluación en la exactitud en la clasificación de densidad de cobertura fue estimada a través de muestreos en campo, empleando matrices de confusión, siendo del 95%. A partir de 2003, este método ha sido utilizado para determinar el pago por servicios ambientales. Dicho pago, junto con una gran interacción con las comunidades, se ha traducido en una reducción en la degradación forestal y la deforestación en la zona núcleo de la Reserva.

  15. SISTEMAS DE VENTILAÇÃO EM TÚNEL E LATERAL NA CRIAÇÃO DE FRANGOS DE CORTE COM ALTA DENSIDADE

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    Neri Zanolla

    1999-12-01

    Full Text Available RESUMO Considerando-se a necessidade de se oferecer às aves um ambiente adequado para que elas possam expressar seu máximo desempenho, especialmente nas criações em alta densidade objetivou-se, com este trabalho, comparar o efeito de dois diferentes sistemas ambientais de acondicionamento térmico (Sistema de Ventilação em Túnel - SVT e Sistema de Ventilação Lateral - SVL, ambos associados à nebulização interna sobre o conforto térmico do galpão e, conseqüentemente, sobre o desempenho produtivo de frangos de corte, em condições de verão, na região de Governador Valadares, MG, cada sistema com densidade de 14 aves m-2, 40% superior à média da região. O experimento foi conduzido dos 15 aos 42 dias de idade das aves, utilizando-se dois galpões idênticos, com dimensões de 12,0 x 120,0 x 3,0 m, orientados no sentido leste-oeste, para os quais foram distribuídos os dois sistemas de arrefecimento térmico (SVT e SVL. O conforto térmico do ambiente foi avaliado pelos índices de temperatura de globo negro e umidade (ITGU e carga térmica de radiação (CTR tomados diariamente, com intervalo de 2 h, das 8:00 às 18:00 h, nas áreas interna e externa dos galpões experimentais. O desempenho produtivo das aves foi avaliado pelo consumo de ração e ganho de peso, medidos semanalmente. Não houve diferença significativa nos índices de conforto térmico ITGU nem CTR, para ambos os sistemas de acondicionamento ambientais. Os resultados médios dos índices de desempenho produtivo das aves no SVT foram melhores que no SVL. Em relação à média dos índices de desempenho das aves, obtidos em lotes anteriores criados nos mesmos galpões experimentais e em condições de verão, verificou-se que a utilização de qualquer um dos dois sistemas de acondicionamento de ambiente permitiu elevar em 40% a densidade do plantel, acompanhado de uma melhoria no desempenho das aves, representada por um acréscimo ao ganho de peso vivo final de

  16. Efeito dos solventes orgânicos sobre o comportamento físico-químico do polietileno de alta densidade (PEAD e polipropileno (PP

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    Thieres Magaive Costa Pereira

    2014-06-01

    Full Text Available O mercado brasileiro de embalagens empregado ao armazenamento de petróleo e seus derivados vem crescendo a cada ano, sendo constituídas basicamente por polietileno de alta densidade (PEAD e polipropileno (PP. Contudo durante o armazenamento, a matriz polimérica fica exposta ao óleo, comprometendo suas propriedades físicas e consequentemente a durabilidade do material. Portanto, estudos relacionados com a interação entre solventes orgânicos e a matriz polimérica tornam-se importantes. Neste trabalho, a interação do PEAD e PP com diferentes solventes apolares (tolueno, n-heptano, n-decano e n-tetradecano foram estudadas em função da temperatura (25, 50 e 80 ºC. Os valores de ganho de massa, coeficientes de difusão, sorção, permeabilidade e parâmetros de mecanismo de transporte foram calculados. O ganho de massa observado para o PP foi maior do que para o PEAD, em todas as temperaturas, sendo que o tolueno foi o solvente responsável pelo maior ganho de massa, atingindo o equilíbrio em um menor intervalo de tempo. Esse resultado corrobora com os valores de coeficiente de difusão e de permeabilidade, que aumentaram na seguinte ordem: n-heptano > n-decano > n-tetradecano. Uma ordem inversa foi observada para os solventes alifáticos quando os valores de coeficiente de sorção foram calculados. O mecanismo de transporte foi também estudado através da regressão dos dados de sorção, sendo classificado como anômalo.

  17. Reologia de polietileno de alta densidade tenacificado com polietileno elastomérico Rheology of high density polyethylene toughened with elastomeric polyethylene

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    Maria José O. C. Guimarães

    2003-06-01

    Full Text Available Neste trabalho foram estudadas as propriedades reológicas de polietileno de alta densidade (HDPE tenacificado com dois tipos de elastômeros metalocênicos à base de poli(etileno-co-octeno (EOC. Estes elastômeros são polímeros comerciais com diferenças quanto ao peso molecular, índice de fluidez e índice Dow de reologia (DRI. Misturas físicas de HDPE e EOC foram processadas em extrusora monorosca Wortex (L/D=32, à 230 °C e 50 rpm, utilizando percentagem mássica dos EOCs de 5% a 80%. As propriedades reológicas foram avaliadas em experimentos estacionários e dinâmicos a 190 °C e taxas de cisalhamento na faixa de 90 s-1 a 1500 s-1 e freqüências na faixa de 10-1 rad/s a 10² rad/s. As misturas HDPE/EOC exibiram pseudoplasticidade e comportamento reológico complexo. A complexidade do comportamento reológico foi acentuada com o aumento do peso molecular e da concentração de ramificações de cadeia longa (DRI do EOC.In this work rheological properties of high density polyethylene toughened with two different grades of metallocene elastomers based on poly(ethylene-co-octene were studied. These elastomers were commercial polymers differing in molecular weight, and Dow Rheology Index (DRI. Blends were processed in a Wortex single screw extruder (L/D=32, at 230 °C and 50 rpm, using mass fractions of EOC in the range from 5% to 80%. The rheological properties were evaluated in steady and dynamic experiments at 190 °C and shear rates in the range from 90 s-1 to 1500 s-1 with frequencies from 10-1 s-1 to 10-2 s-1. The blends exhibited pseudoplasticity and complex rheological behavior. The complex rheological behavior was intensified with increasing molecular weight and long chain branching proportion (DRI in the EOC elastomers.

  18. Identificación de Tareas Isométricas y Dinámicas del Miembro Superior Basada en EMG de Alta Densidad

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    Mónica Rojas- Martínez

    2017-10-01

    Full Text Available Resumen: La identificación de tareas y estimación del movimiento voluntario basados en electromiografía (EMG constituyen un problema conocido que involucra diferentes áreas en sistemas expertos, particularmente la de reconocimiento de patrones, con muchas aplicaciones posibles en dispositivos de asistencia y rehabilitación. La información que proporciona puede resultar útil para el control de exoesqueletos o brazos robóticos utilizados en terapias activas. La tecnología emergente de electromiografía de alta densidad (HD-EMG abre nuevas posibilidades para extraer información neural y ya ha sido reportado que la distribución espacial de mapas de intensidad HD-EMG es una característica valiosa en la identificación de tareas isométricas (contracciones que no producen cambio en la longitud del músculo. Este estudio explora la utilización de la distribución espacial de la actividad mioeléctrica y lleva a cabo identificación de tareas durante ejercicios dinámicos a diferentes velocidades que son mucho más cercanos a los que se utilizan habitualmente en las terapias de rehabilitación. Con este objetivo, se registraron señales HD-EMG en un grupo de sujetos sanos durante la realización de un conjunto de tareas isométricas y dinámicas del miembro superior. Los resultados indican que la distribución espacial es una característica muy útil en la identificación, no solo de contracciones isométricas sino también de contracciones dinámicas, mejorando la eficiencia y naturalidad del control de dispositivos de rehabilitación para que se adapte mejor al usuario. Abstract: Identification of tasks and estimation of volitional movement based on electromyography (EMG constitute a known problem that involves different areas in the field of expert systems and particularly pattern recognition, with many possible applications in assistive and rehabilitation devices. The obtained information can be very useful to control exoskeletons or

  19. Compósitos de partículas de madeira de Eucalyptus grandis, polipropileno e polietileno de alta e baixa densidades Composites of Eucalyptus grandis wood, polypropylene, and high and low-density polyethylene particles

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    Emerson Gomes Milagres

    2006-06-01

    Full Text Available Este trabalho teve como objetivo determinar as propriedades de painéis fabricados com mistura de partículas de madeira de Eucalyptus grandis, polietileno de alta densidade, polietileno de baixa densidade e polipropileno. Empregaram-se duas formulações adesivas (uréia-formaldeído e uréia-formaldeído contendo 0,5% de epóxi. De modo geral, as propriedades dos painéis foram afetadas pela composição das partículas. Os painéis com melhores propriedades foram fabricados com 75% de partículas de madeira e 25% de partículas de polietileno de alta densidade. A adição de epóxi ao adesivo uréico aumentou os valores do módulo de ruptura, dureza Janka, e reduziu o inchamento, em espessura, de alguns painéis. As propriedades mecânicas da maioria dos painéis, exceto o módulo de elasticidade, ultrapassaram os valores mínimos estabelecidos na norma ANSI/A1-208/93.The objective of this work was to establish the properties of particleboards fabricated with blends of Eucalyptus grandis, low-density polyethylene, high-density polyethylene and polypropylene particles. Two adhesives formulations were used (urea-formaldehyde and urea-formaldehyde plus 0,5% of epoxy adhesive. Panel properties were affected by particle composition. Panels with best properties were fabricated with 75% of wood particles and 25% of high density polypropylene. The addition of epoxy to the urea-formaldehyde adhesive improved of the values of modulus of rupture, hardness and reduced the amount of thickness swelling. Except for the modulus of elasticity, board properties meet grade M-2 ANSI/A1-208/93 requirements.

  20. Consumo de alimentos de alta densidad energética en los beneficiarios del programa Oportunidades. El caso del Área Metropolitana de Monterrey

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    Óscar Alfonso Martínez Martínez

    2012-01-01

    refrescos y frituras, entre los beneficiarios y no beneficiarios de dicho programa. Se encontró que no existen diferencias estadísticamente significativas en su consumo, pero sí que las ingestas son altas para ambos grupos.

  1. Higher glandular trichome density in tomato leaflets and repellence to spider mites Alta densidade de tricomas glandulares em tomateiro e aumento da repelência a ácaros rajados

    Directory of Open Access Journals (Sweden)

    Wilson Roberto Maluf

    2007-09-01

    ácaro na superfície do folíolo de tomateiro, após 20, 40 e 60 min. Os biotestes de repelência ao ácaro rajado demonstraram que a alta densidade de tricomas glandulares, especialmente de tipo VI, influencia negativamente a distância média percorrida pelos ácaros na superfície do folíolo. Plantas com número de tricomas glandulares elevado podem ser selecionadas para se obterem genótipos com alto índice de repelência aos ácaros.

  2. ALTAS DENSIDADES DE PLANTIO NA CULTURA DO ABACAXI CV. SMOOTH CAYENNE, SOB CONDIÇÕES DE SEQUEIRO HIGH PLANTING DENSITY FOR THE SMOOTH CAYENNE PINEAPPLE CROP, GROWN UNDER RAINFED CONDITIONS

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    LUCIANA LIMA DE ALMEIDA SANTANA

    2001-08-01

    Full Text Available No Brasil têm-se usado densidades de plantio relativamente baixas para a obtenção de frutos grandes, com reflexos negativos na produtividade da cultura do abacaxi. No entanto, frutos cada vez menores têm sido comercializados no mercado internacional, o que poderá também ocorrer no mercado nacional. Este trabalho teve o objetivo de avaliar o efeito de altas densidades em sistemas de plantio em filas duplas sobre a produção quantitativa e qualitativa de abacaxi cv. Smooth Cayenne, sob condições de sequeiro. Densidades de plantio, variando de 51.280 plantas/ha a 100.000 plantas/ha, foram estudadas em delineamento experimental de blocos casualizados, com cinco repetições e doze tratamentos, distribuídos em esquema fatorial 4 x 3, correspondendo a quatro combinações de espaçamentos entre linhas duplas e entre linhas simples na fila dupla (90cm x 40 cm, 90 cm x 30 cm, 80 cm x 30 cm , 70 cm x 30 cm e três espaçamentos entre plantas nas linhas de plantio (30 cm, 25 cm, 20 cm. A análise de variância determinou diferença estatística apenas para a produtividade, em função do espaçamento entre plantas na linha de plantio, sendo mais elevada para o espaçamento de 20 cm. O peso do fruto, as suas dimensões e a sua qualidade (açucares, acidez, teor de suco, relação açúcares/acidez não foram significativamente influenciados pelas densidades de plantio estudadas, mantendo-se dentro dos padrões da cultivar. Para cada aumento de 10.000 plantas por hectare, a produtividade cresceu em 8,27 t/ha e o peso médio do fruto caiu 102 g. Nas condições ambientais dos Tabuleiros Costeiros do Norte da Bahia, a cultura do abacaxi cv. Smooth Cayenne apresenta potencial para uso em altas densidades de plantio, mesmo em cultivo de sequeiro, podendo-se atingir produtividade acima de 80t/ha e peso médio do fruto superior a 1,0 kg.In Brazil, relatively low planting densities have been used to obtain large fruits, with negative effects on pineapple

  3. Caracterização de compósitos produzidos com polietileno de alta densidade (HDPE e serragem da indústria moveleira – parte II – extrusão em dupla-rosca

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    Éverton Hillig

    2011-06-01

    Full Text Available Neste trabalho, realizou-se a caracterização de compósitos confeccionados com polietileno virgem de alta densidade (v-HDPE e diferentes tipos de serragem gerados na indústria moveleira. O equipamento usado foi uma extrusora de dupla-rosca corrotante, de 19 mm, complementando trabalho anterior no qual os compósitos foram misturados numa extrusora mono-rosca. Utilizou-se temperatura de 180ºC nas cinco zonas de aquecimento, rotação de 150 rpm e vazão de 1 kg.h-1. Foram utilizados resíduos de madeira de pinus (Pinus taeda, de chapa de fibra de média densidade (MDF e madeira de eucalipto (Eucalyptus grandis, que foram incorporados ao HDPE "virgem" juntamente com um agente de acoplamento a base de anidrido maleico. Para caracterização física dos compósitos foram realizadas análises por calorimetria diferencial de varredura (DSC e por microscopia eletrônica de varredura (SEM. Foram também analisadas as propriedades mecânicas de resistência à tração, flexão estática e resistência ao impacto, conforme as normas ASTM D638, D790 e D256 respectivamente. Verificou-se que todos os tipos de serragem agiram como agentes nucleantes, pois os compósitos apresentaram índices de cristalinidade maiores que o v-HDPE puro. Também se observou que houve influência do tipo de serragem usada na dispersão das fibras na matriz polimérica. Os ensaios mecânicos mostraram diferenças nas propriedades dos compósitos confeccionados com diferentes tipos de serragem. De maneira geral, inclusão de serragem de MDF proporcionou compósitos com maior resistência à flexão e ao impacto que aqueles fabricados com eucalipto e pinus. Comparando os valores obtidos nesse trabalho com os obtidos na extrusão com monorrosca, conclui-se que foi possível transferir as propriedades da madeira para o compósito de melhor forma na extrusão com dupla-rosca.

  4. Intensidade de raleio de frutos em pessegueiros 'flordaprince' conduzidos em pomar com alta densidade de plantio Intensity of fruit thinning in peaches 'flordaprince' conducted in orchard of high density

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    JOÃO ALEXIO SCARPARE FILHO

    2000-06-01

    Full Text Available O objetivo deste trabalho foi verificar o comportamento de pessegueiros (Prunus persica (L. Batsch. cultivar Flordaprince, conduzidos em pomar com alta densidade (3.333 plantas/ha, submetidos a diferentes intensidades de raleio manual de frutos. Os tratamentos utilizados foram 120, 100 e 80 frutos por planta, e o controle sem raleio (230 frutos por planta. As plantas submetidas ao raleio produziram frutos significativamente maiores e mais pesados do que os do controle. A produção por planta (kg e a produtividade estimada (t/ha foram maiores nas plantas sem raleio, mas a classificação comercial e a receita bruta (R$/ha desse tratamento foram menores, devido ao menor tamanho e peso dos frutos. Os tratamentos 100 e 80 frutos por planta (56,52% e 65,21% de raleio, respectivamente apresentaram os melhores resultadosThe objective of this paper was to test the behavior of peaches (Prunus persica (L. Batsch. cultivar Flordaprince carried out in high dense orchard (3,333 plants/ha submitted to different intensities of hand thinning of fruits. The treatments tested were 120, 100 and 80 fruits per plant and without thinning (230 fruits per plant. The thinned plants produced larger and weightier fruits if compared with control plants. The yield per plant (kg and estimated productivity (ton/ha were higher in plants not thinned, but marketing classification and gross income were lower in this treatment due to small fruit size and weight. The treatments 100 and 80 fruits per plant (56.52% and 65.21% of thinning, respectively presented the best results.

  5. Concentração plasmática de colesterol total e lipoproteína de alta densidade em novilhas mestiças doadoras de embriões tratadas com somatotropina bovina recombinante Total plasma cholesterol and high-density lipoprotein levels in crossbred heifer embryo donors treated with bovine recombinant somatotropin

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    Á.M. Borges

    2001-10-01

    Full Text Available O objetivo do experimento foi o de estudar as concentrações plasmáticas de colesterol total e lipoproteína de alta densidade (HDL em novilhas mestiças tratadas com somatotropina bovina recombinante (rbST. Coletas de sangue foram feitas durante dois ciclos estrais, normal e superovulado, em 26 fêmeas distribuídas em dois tratamentos: T1 = aplicação de 500mg de rbST no terceiro dia do ciclo estral utilizado para a superovulação e T2 = controle. Análises dos metabólitos sangüíneos foram feitas utilizando-se o método enzimático, cujas concentrações médias plasmáticas de colesterol total e de HDL durante o ciclo estral normal não foram diferentes (P>0,05 entre os dois tratamentos: 87,9 e 25,8mg/dl e 85,9 e 26,7mg/dl para T1 e T2, respectivamente. O ciclo estral utilizado para a superovulação foi dividido em três períodos: P1 = do estro à inseminação artificial (0 ao15º dia, P2 = da inseminação artificial até a coleta de embriões (15º ao 21º dia e P3 = da coleta até o final do período experimental (21º ao 27º dia. As concentrações plasmáticas de colesterol total e HDL no P1 não diferiram entre os tratamentos (P>0,05. Em P2 e P3 houve diferença nas concentrações de HDL e colesterol total entre os dois tratamentos: 29,0 e 88,5mg/dl (T1 e 27,1 e 81,8mg/dl (T2 no P2; e 30,4 e 88,0mg/dl (T1 e 26,6 e 80,5mg/dl (T2 no P3, respectivamente (PThe objective of the experiment was to study the total cholesterol and high-density lipoprotein (HDL levels in crossbred heifers treated with bovine recombinant somatotropina (rbST. Blood samples were collected for two estrous cycles, normal and superovulated, from 26 animals randomly distributed into two treatments: T1 - injected with 500mg rbST on day 3 of estrous cycle and T2 - control. The lipidic metabolite levels were determined by an enzymatic method, and plasma levels of total cholesterol and HDL in normal estrous cycle did not differ (P>0.05 between treatments: 87

  6. Efeito do bebedouro e da densidade no desempenho de frangos alojados em alta temperatura Effect of type of water facility and density on performance of broiler reared in hot-climate

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    José H.V. Silva

    2005-12-01

    Full Text Available Com o objetivo de avaliar o efeito do bebedouro pendular (BP e do bebedouro alternativo (BALT, e de diferentes densidades (10 e 14 aves m-2 sobre o desempenho de 240 frangos de corte de 12 a 18, 19 a 38 e de 39 a 46 dias de idade, realizou-se este experimento em condições de temperatura média de 27,6 ºC e umidade relativa de 70,4%, no qual foi utilizado um delineamento inteiramente casualizado em esquema fatorial 2 x 2 (dois bebedouros x duas densidades, resultando em quatro tratamentos constituídos de cinco repetições de 10 aves. O BALT foi desenvolvido com base no conceito de amplo espaço de calha circular e alta profundidade de lâmina de água (5 cm para permitir a imersão do bico e das faces da ave. Na alimentação das aves, foram utilizadas rações comerciais, cujo consumo (CR caiu, enquanto a conversão alimentar (CA melhorou, quando o BALT foi empregado de 12 a 18 dias. Não houve efeito do bebedouro sobre o CR, ganho de peso (GP e CA no período total. A D14 (14 aves m-2 afetou o GP e o CR de 19 a 38 e de 39 a 46 dias e também no período total, mas a CA não foi alterada. O BALT não afeta o desempenho de frangos de corte, podendo ser usado como opção de baixo custo ao BP. A análise econômica pelo índice de rentabilidade relativa mostrou que o BALT e a D14 oferecem 1 e 5,9% de retorno a mais que o BP e a D10, (10 aves m-2 respectivamente.The experiment was undertaken in conditions of average temperature of 27.6 ºC and relative humidity of 70.4%, with the objective to evaluate bell (BD and alternative (ALT water facility and stocking densities (SD of 10 and 14 broilers m-2 (SD10 and SD14, on performance of 240 broiler chickens of 12 to 18, 19 to 38 and 39 to 46 days of age, allotted in boxes in a completely randomized design in 2 x 2 factorial arrangement (two types of drinking facility and two stocking densities, resulting in four treatments, each one with five replications of ten birds. The ALT was developed based on

  7. Caracterização de compósitos produzidos com polietileno de alta densidade (HDPE e serragem da indústria moveleira Characterization of composites made from high density polythylene (HDPE and furniture industry sawdust

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    Éverton Hillig

    2008-04-01

    Full Text Available Neste trabalho, realizou-se a caracterização de compósitos confeccionados com polietileno de alta densidade "virgem" (v-HDPE e diferentes tipos de serragem gerados na indústria moveleira. Os compósitos foram produzidos por extrusão, utilizando-se uma extrusora monorrosca de 35 mm e temperaturas de 160 ºC, 170 ºC e 180 ºC nas zonas 1, 2 e 3, respectivamente. Foram utilizados resíduos de madeira de pinus (Pinus taeda, de aglomerado, de chapa de fibra de média densidade (MDF e madeira de eucalipto (Eucalyptus grandis, que foram incorporados ao HDPE "virgem", juntamente com um agente de acoplamento à base de anidrido maléico. Para caracterização física dos compósitos, foram realizadas análises por calorimetria diferencial de varredura (DSC e por microscopia eletrônica de varredura (SEM. Foram também analisadas as propriedades mecânicas de resistência à tração, flexão estática e resistência ao impacto, conforme as normas ASTM D638, D790 e D256. Verificou-se que todos os tipos de serragem agiram como agentes nucleantes, pois os compósitos apresentaram índices de cristalinidade maiores que o v-HDPE puro, e houve influência do tipo de serragem usada na dispersão das fibras na matriz polimérica. Os ensaios mecânicos indicaram diferenças nas propriedades dos compósitos confeccionados com diferentes tipos de serragem. De maneira geral, a inclusão de serragem de aglomerado e de eucalipto proporcionaram compósitos com maior resistência à flexão e ao impacto que aqueles fabricados com MDF e pinus.This work aimed to carry out a characterization of composites made of high density polyethylene (HDPE and different types of furniture industry-derived sawdust. The composites were produced by extrusion, using a 35 mm single-screw extruder, at temperatures of 160ºC, 170ºC and 180ºC in zones 1, 2 and 3, respectively. Particleboard residues from Pinus taeda sawdust, Medium Density Fiberboard (MDF and Eucalyptus grandis wood

  8. Polietileno de Alta Densidade Tenacificado com Elastômero Metalocênico: 1. Propriedades Mecânicas e Características Morfológicas Rubber Toughened High Density Polyethylene: 1. Mechanical Properties and Morphological Characteristics

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    Maria José O. C. Guimarães

    2002-01-01

    Full Text Available Neste trabalho foram estudadas as propriedades mecânicas e morfológicas de polietileno de alta densidade (HDPE tenacificado com dois tipos de elastômeros metalocênicos à base de etileno/1- octeno (EOC. Esses elastômeros são polímeros comerciais com diferenças quanto ao peso molecular, índice de fluidez e índice Dow de reologia (DRI. Misturas físicas de HDPE e EOC foram processadas em extrusora monorosca Wortex (L/D=32, à 230°C e 50 rpm, utilizando percentagem mássica do EOC de 5% a 80%. Foi observado um efeito sinergístico nas propriedades tênseis e características de supertenacificação para materiais contendo proporções do EOC maiores do que 5%. Cavitação, deformação plástica e cavitação fibrilada foram observados nos processos de deformação. Materiais contendo até 50% do EOC apresentaram morfologias dispersas com domínios elastoméricos esféricos, distribuídos uniformemente e com tamanho médio de partícula na faixa de 0,30 a 0,45 µm. A tenacificação de HDPE com os elastômeros etilênicos produziu materiais com boas propriedades e compatibilização tecnológica devido à existência de baixa tensão interfacial entre esses polímeros.The mechanical and morphological properties of high density polyethylene (HDPE toughened with two different grades of metallocene elastomers based on ethylene/1- octene (EOC were studied. These elastomers were commercial polymers differing in molecular weight, melt flow index and Dow rheology index (DRI. Blends were processed in a Wortex single screw extruder (L/D=32, at 230°C and 50 rpm, using mass fraction weight percent of EOC in the range from 5% to 80%. A synergistic effect on the tensile properties and supertough behavior for blends with EOC concentrations higher than 5% was observed. Cavitation, plastic deformation and fibrillized cavitation were observed in the deformation processes. Materials containing up to 50% of EOC exhibited dispersed morphologies with EOC

  9. Actualización en el manejo del colesterol hdl bajo

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    Rigotti R. Attilio, Dr.

    2012-11-01

    Full Text Available Los niveles plasmáticos bajos de colesterol transportado en las lipoproteínas de alta densidad (HDL constituyen un elemento independiente de riesgo cardiovascular ateroesclerótico. Algunos protocolos clínicos enfocados en el manejo farmacológico de los niveles bajos de colesterol HDL en pacientes de alto riesgo cardiovascular han mostrado resultados favorables. Por otro lado, existen nuevas formulaciones de la niacina, el agente farmacológico disponible más efectivo para el manejo del colesterol HDL bajo, y se están desarrollando nuevos fármacos más potentes para aumentar los niveles plasmáticos de colesterol HDL. En el futuro, nuevos medicamentos que modulen el metabolismo de HDL y demuestren beneficio sobre el control del riesgo cardiovascular ateroesclerótico, podrían mejorar aún más el manejo actual de esta condición patológica que se basa esencialmente en el uso de estatinas.

  10. Fertilización de base en un cultivo inicial de pecan con dos marcos de plantación de alta densidad Effect of different fertilization strategies on pecan growth parameters under two high density plantation frames

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    Lidia Giuffré

    2011-07-01

    Full Text Available El pecán, Carya illinoensis Koch, es una especie cuyo fruto es reconocido como un alimento altamente saludable. Su cultivo se encuentra en expansión en la Argentina pero existen muy pocas investigaciones sobre fertilización y sistemas de plantación. Los objetivos del trabajo fueron caracterizar algunas propiedades físico-químicas y químicas de un suelo en el que se inicia un cultivo de pecán, y comparar tratamientos de fertilización de base (FB en dos marcos de plantación de alta densidad (MP. Se realizó una plantación de pecán en Villanueva (provincia de Buenos Aires, sobre un suelo Hapludol taptoárgico, con dos marcos de plantación: 10 x 10 m (marco real: MR y 8 x 8 m (tresbolillo: TR. El diseño del experimento fue en parcelas divididas con cuatro repeticiones. La parcela principal fueron los dos marcos de plantación, y las subparcelas fueron los distintos tratamientos de fertilización base: Compost (C, Fósforo (P, Nitrógeno (N y Control sin fertilización base (T. Las determinaciones para evaluar el crecimiento de las plantas de pecán fueron: la altura de las plantas y el diámetro del tronco. Con respecto a la fertilidad del suelo, la fertilización fosforada y el agregado de compost permitieron aumentar significativamente los niveles de P-Bray. El tratamiento con fertilización orgánica: compost, presentó un incremento significativo en altura de los pecanes en el marco de plantación 8 x 8 m, que no se manifestó en ningún caso en los diámetros del tronco, con una interacción MP x FB significativa (P=0,01 para la variación de altura al primer año. La variación del volumen del árbol durante el año de experimentación no presentó efectos significativos según el marco de plantación ni la fertilización base aplicada.The fruit of the pecan tree, Carya illinoensis Koch, is considered a very healthy food. In Argentina, pecan cultivation has been expanding rapidly but very little research has been conducted on

  11. Rejuvenecimiento de manos con ácido hialurónico de alta densidad: estudio prospectivo en 29 pacientes Hands rejuvenation with high density hyaluronic acid: prospective study in 29 patients

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    J.M. Alcolea

    2012-12-01

    Full Text Available El objetivo del presente estudio prospectivo es valorar a corto, medio y largo plazo, la eficacia en el rejuvenecimiento de las manos de la inyección subcutánea de ácido hialurónico (AH, Macrolane® 20, de alta densidad y partículas grandes, teniendo en cuenta el beneficio del tratamiento, la satisfacción de los pacientes y las posibles complicaciones. Este estudio se realizó entre mayo del 2010 y diciembre del 2011. Se seleccionaron 29 pacientes al azar entre 51 y 74 años de edad con fototipos II a IV, a los que se les inyectó AH para rejuvenecer las manos. La cantidad de AH inyectada en cada mano fue de 1 a 2 ml. Se realizaron controles sistemáticos en la 2ª semana, en los meses 1º, 3º, 6º, 9º y 12º. Se tuvieron en cuenta las complicaciones en cada paciente en todos los controles. En el primer control, en la 2ª semana, junto al examen clínico se practicó examen ecográfico a fin de determinar si sería necesaria una segunda inyección de AH. En cada uno de los controles los pacientes contestaron a un formulario para indagar sobre su grado de satisfacción con el tratamiento. Solo 1 paciente presentó edema y 3 tuvieron equimosis leve; 2 pacientes manifestaron dolor leve con las inyecciones y 2 requirieron una segunda inyección tras la valoración en la 2ª semana. La satisfacción de los pacientes en los controles superó la valoración clínica y fotográfica. En nuestra opinión, el rejuvenecimiento de las manos con este tipo de AH de grandes partículas tiene una baja tasa de complicaciones y es bien tolerado, con un alto grado de satisfacción por parte de los pacientes y una notable mejoría de los parámetros estudiados: arrugas, aspecto de la atrofia dérmica y subcutánea y disminución de los relieves óseos, tendinosos y venosos. La valoración tanto subjetiva como objetiva se hizo hasta el año de seguimiento con buenos resultados.The aim of this prospective study is to assess the efficacy of a high density

  12. HDL and the menopause.

    Science.gov (United States)

    El Khoudary, Samar R

    2017-08-01

    To summarize recent provocative findings on conventional and novel metrics of HDL including HDL-C, HDL subclasses and HDL cholesterol efflux capacity as related to menopause. Pattern of menopause-related changes in HDL-C are not consistent, suggesting a complex relationship between HDL and menopause. Growing body of literature indicates that higher levels of HDL-C may not be consistently cardio-protective in midlife women, suggesting a potential change in other metrics of HDL that could not be captured by the static metric HDL-C. It is also possible that higher HDL-C at certain conditions could be a marker of HDL metabolism dysfunctionality. Significant alterations in other metrics of HDL have been reported after menopause and found to be related to estradiol. The impact of changes in novel metrics of HDL over the menopausal transition on cardiovascular disease (CVD) risk later in life is not clear in women. Much of our understanding of how the menopausal transition may impact HDL metrics comes from cross-sectional studies. Future longitudinal studies are needed to evaluate other metrics of HDL shown to better reflect the cardio-protective capacities of HDL, so that the complex association of menopause, HDL and CVD risk could be characterized.

  13. Avaliação de rações de alta densidade nutricional para porcas em lactação no verão Evaluation of rations with high nutritional density rations for lactation sows during the summer

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    Douglas Haese

    2010-07-01

    Full Text Available Para avaliar dietas de alta densidade nutricional, com ou sem suplementação de aminoácidos industriais, ajustadas com base na energia líquida, utilizaram-se 80 porcas pluríparas, em lactação, do mesmo padrão genético, distribuídas em delineamento experimental de blocos composto por quatro dietas, 20 blocos, considerando cada porca uma unidade experimental. Na formação dos blocos, utilizaram-se como critérios o peso e a ordem de parto das porcas. As dietas foram formuladas com a combinação de quatro níveis de proteína bruta (18,33; 15,23; 19,63; ou 16,59%, quatro de energia metabolizável (3.344; 3.293; 3.480; e 3.440 kcal/kg, dois de lisina digestível (0,85 e 0,95% e dois de energia líquida (2.519 e 2.636 kcal de EL/kg e da suplementação com aminoácidos industriais até a relação triptofano:lisina digestíveis de 18%. Não houve efeito das dietas com alta densidade nutricional, com ou sem suplementação de aminoácidos, sobre o consumo médio diário de ração. As dietas também não influenciaram o peso, a perda e variação de peso, o intervalo desmama-estro nem a estimativa da produção de leite das porcas no período de lactação. Dietas de alta densidade nutricional (lisina e energia para porcas em lactação são eficientes em reduzir a mobilização de reservas corporais e não afetam os desempenhos produtivo e reprodutivo das porcas.In order to evaluate diets with high nutritional density, with or without industrial amino acid supplementation, adjusted at net energy base, it was used 80 pluriparous lactating sows with the same genetic pattern, distributed in an experimental block design composed of four diets, 20 blocks, considering each sow an experimental unity. The criteria used for formation of the blocks were the weight and parity order. Diets were formulated by the combination of four levels of crude protein (18.33; 15.23; 19.63; or 16.59%, four levels of metabolizable energy (3,344; 3,293; 3,480; and 3

  14. RESISTENCIA MECÁNICA EVALUADA EN EL ENSAYO MARSHALL DE MEZCLAS DENSAS EN CALIENTE ELABORADAS CON ASFALTOS MODIFICADOS CON DESECHOS DE POLICLORURO DE VINILO (PVC, POLIETILENO DE ALTA DENSIDAD (PEAD Y POLIESTIRENO (PS MECHANICAL RESISTANCE OF HOT THICK MIXTURES MADE WITH ASPHALT MODIFIED WITH POLYVINYL CHLORIDE, POLYCLORURE (PVC WASTES, HIGH DENSITY POLYETHYLENE (PEAD, AND POLYSTYRENE (PS EVALUATED IN MARSHALL ASSAY

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    Hugo Alexánder Rondón Quintana

    2007-07-01

    Full Text Available El presente trabajo buscó evaluar en laboratorio el cambio en la resistencia mecánica que experimentan mezclas asfálticas densas en caliente cuando se adicionan, por vía húmeda, al cemento asfáltico aditivos poliméricos producto de desechos industriales del tipo plastómero (policloruro de vinilo, polietileno de alta densidad y poliestireno. Para tal fin se empleó el ensayo Marshall. De los resultados obtenidos se concluye que la resistencia mecánica de mezclas asfálticas modificadas con desechos del tipo plastómero es mayor en comparación con las convencionales (mezclas que emplean asfaltos sin ningún aditivo.The main objective of this research Project was to evaluate in a laboratory the change in mechanical strength that dense hot asphalt mixtures go through when waste polymeric additives of plastomeric type (polyvinyl chloride, high density polyethylene and polystyrene are added to asphalt cement, by 'wet way'. This change was evaluated using Marshall Test. The general conclusion of the experimental results was that modified hot asphalt mixtures present better mechanical behavior than conventional mixtures (mixtures which use asphalt without additives.

  15. HDL: The "Good" Cholesterol

    Science.gov (United States)

    ... There are two main types of cholesterol: HDL (good) cholesterol and LDL (bad) cholesterol: HDL stands for high-density lipoproteins. It is called the "good" cholesterol because it carries cholesterol from other parts ...

  16. Addition of nitrogen had no effect on yield and quality of apples in an high density orchard carrying a dwarf rootstock A adição de nitrogênio não afetou o rendimento e a qualidade de maçãs em pomar com alta densidade e porta-enxerto anão

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    Paulo Roberto Ernani

    2008-12-01

    alta densidade sobre porta-enxerto anão (M.9. O pomar com a cultivar Royal Gala foi plantado em 1995, na densidade de 2.857 plantas ha-1, em um Latossolo Bruno com 40 g kg-1 de matéria orgânica e pH 6,0. O experimento foi implantado em 1998 e foi encerrado em 2005. Os tratamentos consistiram da aplicação anual de 0; 50; 100 e 150 kg ha-1 de N de 1998 até 2001 e de, respectivamente, 0; 100; 200 e 300 kg ha-1 de N a partir da safra 2002-2003. Metade de cada dose foi aplicada no início da brotação, e o restante após a colheita, sempre na forma de sulfato de amônio. A aplicação de N ao solo não influenciou no rendimento de frutos em nenhuma das seis safras, independentemente da dose. Na média das doses e dos anos, o rendimento foi de 52,3 t ha-1. A adição de N também não afetou a concentração de N nas folhas (média de 24 g kg-1 e nos frutos (media de 346 mg kg-1, nem tampouco os atributos relacionados com a qualidade dos frutos (cor da epiderme, firmeza da polpa, acidez, sólidos solúveis, desordens fisiológicas. Alguns atributos relacionados com o vigor das plantas, entretanto, aumentaram com o aumento da dose de N. Portanto, em solos profundos do Sul do Brasil, com alto teor de matéria orgânica, não é necessário aplicar N para obter altas produtividades e frutos de boa qualidade em pomares de 'Royal Gala' contendo porta-enxerto anão (M.9 e alta densidade de plantas, provavelmente porque a necessidade das árvores é suprida pelo N oriundo da decomposição orgânica.

  17. High density of defoliated tomato plants in protected cultivation and its effects on development of trusses and fruits Alta densidade com desfolhamento de plantas de tomateiro em cultivo protegido e seus efeitos sobre o desenvolvimento de inflorescências e frutos

    Directory of Open Access Journals (Sweden)

    Miguel A. Sandri

    2002-09-01

    ground area seems to be the upper limit in maximizing the number of set fruits of this crop.O número de frutos em plantas de tomateiro cultivadas em alta densidade e com índice de área foliar similar mantido através de desfolhamento foi determinado em três condições ambientais, no interior de túneis de polietileno. O experimento 1 foi conduzido no outono, com radiação solar média recebida pela cultura de 8,0 MJ m-2 dia-1 e temperatura média exterior de 18,1ºC. Os experimentos 2 e 3 foram conduzidos na primavera, com temperatura média exterior de 19,7ºC. No experimento 2, a radiação solar média recebida pela cultura foi de 12,4 MJ m-2 dia-1, enquanto no experimento 3 foi reduzida para 5,9 MJ m-2 dia-1 por meio de uma tela com 52% de sombreamento. As plantas foram cultivadas em sacolas, com 1,0 m entre fileiras e 0,3 m entre sacolas, enchidas com 5,5 L de substrato comercial. Nutrientes e água foram fornecidos via solução nutritiva, de forma a repor os volumes perdidos pela transpiração. Os tratamentos consistiram de uma (T1, duas (T2 e três (T3 plantas por sacola, correspondendo a densidades de 3,3; 6,7 e 10 plantas m-2, respectivamente. Em T1, três folhas por simpódio foram mantidas, com uma proporção de 3:1 entre o número de folhas e de inflorescências, em cada simpódio. Em T2, duas e uma folha foram mantidas respectivamente em dois simpódios consecutivos, alternativamente em ambas as plantas da sacola. A relação entre o número de folhas e de inflorescências foi de 3:2. Em T3, com três plantas por sacola, somente uma folha por simpódio foi mantida, com uma relação de 3:3. Em todos os experimentos, o número de inflorescências por unidade de área em T2 e T3 foi duas e três vezes maior que em T1, respectivamente. O número de frutos fixados por área de solo foi menor em T1 e similar em T2 e T3 no primeiro experimento, enquanto no segundo e terceiro experimentos valores similares foram observados entre os tratamentos. Os

  18. Comportamento térmico, mecânico e morfológico de compósitos de polietileno de alta densidade reciclado com fibra de piaçava Thermal, mechanical and morphological behavior of recycled high- density polyethylene reinforced with piassava fiber

    Directory of Open Access Journals (Sweden)

    Claudia M. C. Bonelli

    2005-11-01

    Full Text Available O uso de fibras naturais como reforçadores para termoplásticos tem despertado interesse crescente, principalmente para termoplásticos reciclados, devido ao baixo custo, utilização de recursos naturais brasileiros disponíveis, além de contribuir para a despoluição ambiental. No presente trabalho foram avaliadas as propriedades térmicas, mecânicas e morfológicas de compósitos de polietileno de alta densidade reciclado (HDPE-r e fibra de piaçava da Amazônia (Leopoldinia piassaba, tratada e não-tratada, em diferentes proporções (5, 10 e 15% de fibra. O trabalho tem como objetivo a obtenção de compósitos a fim de atender as exigências do mercado como materiais alternativos, visando à fabricação de placas de baixo custo para estruturas sob pequeno esforço. As fibras foram submetidas a tratamento superficial com silano de duas formas: impregnação direta (fibra-ts e com solução metanólica (fibra-tms. Foi verificado que os compósitos HDPE-r / fibra-ts apresentaram melhor desempenho mecânico que os obtidos com fibra-tms, em função da remoção pelo metanol da fração contendo lignina, componente estrutural da fibra. O aumento da adesão fibra-matriz de HDPE reciclado em compósitos com fibra tratada, conforme observado pelas microfratografias apresentadas, pode explicar este desempenho. A estabilidade térmica dos compósitos foi pouco afetada com a incorporação da fibra tratada.The use of natural fibers as reinforcement for thermoplastics, especially for recycled thermoplastics, has generated much interest due to their low cost, possibility of environmental protection and use of locally available renewable resources. In this work we evaluate the thermal, mechanical and morphological properties of composites of recycled high-density polyethylene (HDPE-r with treated and untreated piassaba fibers (Leopoldinia piassaba in different proportions (5, 10 and 15% w/w. The objective of this work is to obtain composites of

  19. Preparação e caracterização de biocompósitos baseados em fibra de curauá, biopolietileno de alta densidade (BPEAD e polibutadieno líquido hidroxilado (PBHL Preparation and characterization of biocomposites based on curaua fibers, high-density biopolyethylene (HDBPE and liquid hydroxylated polybutadiene(LHPB

    Directory of Open Access Journals (Sweden)

    Daniele O. Castro

    2013-01-01

    Full Text Available Neste trabalho, foram utilizadas fibras de curauá como reforço de matriz termoplástica de biopolietileno de alta densidade. O polietileno foi obtido por polimerização de eteno, gerado do etanol de cana de açúcar. Este polímero é também chamado de biopolietileno (BPEAD, por ser preparado a partir de material oriundo de fonte natural. Desta forma, pretendeu-se contribuir para desenvolver materiais que, dentre outras propriedades, causem menor emissão de CO2 para a atmosfera na sua produção, utilização e substituição, comparativamente a outros materiais. Adicionalmente, polibutadieno líquido hidroxilado (PBHL foi acrescentado à formulação do compósito, visando a um aumento na resistência à propagação da trinca durante impacto. Os compósitos e as fibras foram caracterizados por várias técnicas, tais como microscopia eletrônica de varredura (MEV, Calorimetria Exploratória Diferencial (DSC, Termogravimetria (TG, além da caracterização dos compósitos quanto à Análise Térmica Dinâmico-Mecânica (DMTA, propriedades mecânicas (impacto e flexão e absorção de água. A presença das fibras de curauá diminuiu algumas propriedades do BPEAD, como resistência ao impacto. A análise de DMTA mostrou que as fibras geram material mais rígido. Pode-se considerar que a introdução de PBHL na formulação do material foi eficiente, levando a uma resistência ao impacto do compósito BPEAD/PBHL/Fibra maior do que a do compósito BPEAD/Fibra.In this work, curaua fibers were used in the reinforcement of a high-density (HDPE thermoplastic matrix. The polyethylene used was obtained by polymerization of ethene produced from sugarcane ethanol. This polymer, also called high-density biopolyethylene (HDBPE, was prepared from a natural source material. The aim was to contribute to developing materials which could lead to smaller release of CO2 into the atmosphere in comparison to other materials. Additionally, liquid

  20. Genetic determinants of HDL metabolism.

    Science.gov (United States)

    Ossoli, A; Gomaraschi, M; Franceschini, G; Calabresi, L

    2014-01-01

    Plasma high density lipoproteins (HDL) comprise a highly heterogeneous family of lipoprotein particles, with subclasses that can be separated and identified according to density, size, surface charge as well as shape and protein composition. There is evidence that these subclasses may differ in their functional properties. The individual plasma HDL cholesterol (HDL-C) level is generally taken as a snapshot of the steady-state concentration of all circulating HDL subclasses together, but this is insufficient to capture the structural and functional variation in HDL particles. HDL are continuously remodeled and metabolized in plasma and interstitial fluids, through the interaction with a large number of factors, including structural proteins, membrane transporters, enzymes, transfer proteins and receptors. Genetic variation in these factors can lead to essential changes in plasma HDL levels, and to remarkable changes in HDL particle density, size, surface charge, shape, and composition in lipids and apolipoproteins. This review discusses the impact of rare mutations and common variants in genes encoding factors involved in HDL remodeling and metabolism on plasma HDL-C levels and particle distribution. The study of the effects of human genetic variation in major players in HDL metabolism provides important clues on how individual factors modulate the formation, maturation, remodeling and catabolism of HDL.

  1. Modelado y metodología analítica de diseño de transformadores de potencia y alta frecuencia: análisis de los devanados, optimización de eficiencia y densidad de potencia e integración en el diseño de convertidores electrónicos

    OpenAIRE

    Barrios Rípodas, Ernesto

    2015-01-01

    Esta tesis se centra en el estudio y análisis del diseño de transformadores de potencia y alta frecuencia. Los principales temas tratados en esta tesis se resumen a continuación: - Realización del estado del arte y síntesis del modelado de transformadores de potencia y alta frecuencia, haciendo especial hincapié en el estudio de los materiales magnéticos, los fenómenos de alta frecuencia en los devanados, el cálculo de pérdidas en el núcleo y en el cobre y las técnicas que perm...

  2. 77 FR 29633 - Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC...

    Science.gov (United States)

    2012-05-18

    ..., Alta Wind XIV, LLC, Alta Wind XV, LLC, Alta Windpower Development, LLC, TGP Development Company, LLC... XIII, LLC, Alta Wind XIV, LLC, Alta Wind XV, LLC, Alta Windpower Development, LLC, and TGP Development...

  3. to HDL-cholesterol functionality

    Directory of Open Access Journals (Sweden)

    Malara Marzena

    2016-05-01

    Full Text Available The purpose of this study was to analyse the scientific evidence concerning the effects of two enzymes – paraoxonase 1 and myeloperoxidase – on the functions of HDL-cholesterol. It is well documented that disturbed circulating lipoproteins (a high total and high LDL-cholesterol, and low HDL-cholesterol bring about atherosclerosis and an increased risk of cardiovascular disease (CVD which is recognised as the main cause of death all around the world. In consequence, numerous studies have focused on procedures which will improve the plasma lipoproteins profile by decreasing the total cholesterol and the LDL-cholesterol (LDL-C and increasing the HDL-cholesterol (HDL-C. However, the anti-atherogenic role of HDL-C has been challenged in studies showing that genetically elevated HDL-cholesterol does not offer protection against CVD. Moreover, it has been found that raising the circulating HDL-cholesterol fails to reduce atherosclerosis. The doubts concerning the protective role of HDL-C have been supported by in vitro studies which indicate that the HDL-C from patients with atherosclerosis does not have a protective action, but does stimulate inflammation and free radical synthesis. The above data suggests that HDL-C, commonly recognised as protective against atherosclerosis, in some circumstances becomes pro-atherogenic, and is thus dysfunctional. Our review focuses on two enzymes – paraoxonase 1 (PON1 and myeloperoxidase (MPO – which markedly affect the properties of HDL-C and contribute to its anti – or pro-atherogenic activity. Moreover, the effects of the diet and physical activity on PON1 and MPO are summarised with respect to the HDL-C functionality.

  4. Raising HDL cholesterol in women

    Directory of Open Access Journals (Sweden)

    Danny J Eapen

    2009-11-01

    Full Text Available Danny J Eapen1, Girish L Kalra1, Luay Rifai1, Christina A Eapen2, Nadya Merchant1, Bobby V Khan11Emory University School of Medicine, Atlanta, GA, USA; 2University of South Florida School of Medicine, Tampa, FL, USAAbstract: High-density lipoprotein cholesterol (HDL-C concentration is essential in the determination of coronary heart disease (CHD risk in women. This is especially true in the postmenopausal state, where lipid profiles and CHD risk mimic that of age-matched men. Thus, interventions designed to reduce CHD risk by raising HDL-C levels may have particular significance during the transition to menopause. This review discusses HDL-C-raising therapies and the role of HDL in the primary prevention of CHD in women. Lifestyle-based interventions such as dietary change, aerobic exercise regimens, and smoking cessation are initial steps that are effective in raising HDL-C, and available data suggest women respond similarly to men with these interventions. When combined with pharmacotherapy, the effects of these lifestyle alterations are further amplified. Though studies demonstrating gender-specific differences in therapy are limited, niacin continues to be the most effective agent in raising HDL-C levels, especially when used in combination with fibrate or statin therapy. Emerging treatments such as HDL mimetic therapy show much promise in further raising HDL-C levels and improving cardiovascular outcomes.Keywords: high-density lipoprotein, HDL, women, cholesterol, heart disease

  5. MATÉRIA SECA E ABSORÇÃO DE NUTRIENTES EM FUNÇÃO DO ESPAÇAMENTO E DA DENSIDADE DE SEMEADURA EM ARROZ DE TERRA ALTA DRY MATTER AND NUTRIENT UPTAKE OF DRYLAND RICE RELATED TO ROW SPACING AND PLANT POPULATION

    Directory of Open Access Journals (Sweden)

    Carlos Alexandre Costa Crusciol

    1999-01-01

    Full Text Available Foi instalado um experimento em condições de campo, em um Latossolo Vermelho escuro, epi-eutrófico, textura argilosa, em Selvíria-MS, com arroz de sequeiro cv. IAC 201, estudando-se três espaçamentos entre fileiras (30, 40 e 50 cm e três densidades de semeadura (100, 150 e 200 sementes viáveis/m2. Foram avaliadas a produção de matéria seca da parte aérea no momento do florescimento e determinados os teores e quantidades de N, P, K, Ca, Mg e S absorvidos, assim como a eficiência de utilização de nutrientes. A redução do espaçamento entre fileiras aumentou a produção de matéria seca da parte aérea e a quantidade de nutrientes absorvidos. A variação da densidade de semeadura não afetou os parâmetros estudados. A redução do espaçamento entre fileiras proporcionou maior eficiência de utilização do Ca e diminuiu a do N e Mg. Os teores de nutrientes na matéria seca da parte aérea não foram afetados pela variação do espaçamento entre fileiras.A field experiment was conducted in a clayey Dark Red Latosol in Selviria, MS, Brazil, to study the effect of three row spacings (30, 40 and 50 cm and three seed densities (100, 150 and 200 viable seeds/m2 on plant dry matter yield, macronutrient (N, P, K, Ca, Mg and S uptake at flowering, and the nutrient use efficiency. A decrease in row spacing led to an increase in shoot dry matter production and nutrient uptake. There was no effect of plant densities on dry matter or nutrient uptake. The decrease in row spacing allowed a higher Ca use efficiency, but not for N and Mg. The concentration of the macronutrients in the shoots was not affected by spacing.

  6. Suplementação nutricional com antioxidantes naturais: efeito da rutina na concentração de colesterol-HDL

    Directory of Open Access Journals (Sweden)

    Rodrigues Hosana Gomes

    2003-01-01

    Full Text Available O estresse oxidativo está freqüentemente associado com alterações nas concentrações séricas de glicose e lipídios. O objetivo deste trabalho foi verificar se as alterações bioquímicas séricas, induzidas pela suplementação nutricional com o flavonóide rutina, estão associadas a propriedades antioxidantes. A administração de rutina (120mg/kg/semana, durante 15 dias, não induziu variação na glicemia de jejum e no teste de tolerância à glicose. Embora não tenham sido observadas mudanças significativas nas concentrações séricas de lipoperóxidos, triacilglicerois, colesterol-LDL e proteínas totais, a suplementação nutricional com rutina demonstrou importante papel na prevenção da aterosclerose, pois induziu elevação significativa da lipoproteína de alta densidade (colesterol-HDL de 35,82 ± 2,31mg/dL para 44,40 ± 3,11mg/dL. Como não foram observadas alterações na glutationa peroxidase, enquanto as atividades da superóxido dismutase foram elevadas pela ingestão de rutina. Pode-se concluir que os efeitos antioxidantes deste flavonoide, aumentando a concentração de colesterol-HDL, estão relacionados à elevação nas atividades da superóxido dismutase. A ação antioxidante da rutina pode estar relacionada à destruição do radical superóxido (O2-.

  7. HDL cholesterol: atherosclerosis and beyond

    NARCIS (Netherlands)

    Bochem, A.E.

    2013-01-01

    Cardiovascular disease (CVD) is the leading cause of death in the Western world. Myocardial infarction and stroke are the result of a compromised blood flow which may result from cholesterol accumulation in the vessel wall due to high plasma levels of LDL cholesterol. High plasma levels of HDL

  8. HDL Particle Measurement: Comparison of 5 Methods.

    Science.gov (United States)

    Matera, Robert; Horvath, Katalin V; Nair, Hari; Schaefer, Ernst J; Asztalos, Bela F

    2018-03-01

    HDL cell cholesterol efflux capacity has been documented as superior to HDL cholesterol (HDL-C) in predicting cardiovascular disease risk. HDL functions relate to its composition. Compositional assays are easier to perform and standardize than functional tests and are more practical for routine testing. Our goal was to compare measurements of HDL particles by 5 different separation methods. HDL subfractions were measured in 98 samples using vertical auto profiling (VAP), ion mobility (IM), nuclear magnetic resonance (NMR), native 2-dimensional gel electrophoresis (2D-PAGE), and pre-β1-ELISA. VAP measured cholesterol in large HDL 2 and small HDL 3 ; IM measured particle number directly in large, intermediate, and small HDL particles; NMR measured lipid signals in large, medium, and small HDL; 2D-PAGE measured apolipoprotein (apo) A-I in large (α1), medium (α2), small (α3-4), and pre-β1 HDL particles; and ELISA measured apoA-I in pre-β1-HDL. The data were normalized and compared using Passing-Bablok, Lin concordance, and Bland-Altman plot analyses. With decreasing HDL-C concentration, NMR measured a gradually lower percentage of large HDL, compared with IM, VAP, and 2D-PAGE. In the lowest HDL-C tertile, NMR measured 8% of large HDL, compared with IM, 22%; VAP, 20%; and 2D-PAGE, 18%. There was strong discordance between 2D-PAGE and NMR in measuring medium HDL ( R 2 = 0.356; r c = 0.042) and small HDL ( R 2 = 0.376; r c = 0.040). The 2D-PAGE assay measured a significantly higher apoA-I concentration in pre-β1-HDL than the pre-β1-ELISA (9.8 vs 1.6 mg/dL; R 2 = 0.246; r c = 0.130). NMR agreed poorly with the other methods in measuring large HDL, particularly in low HDL-C individuals. Similarly, there was strong discordance in pre-β1-HDL measurements between the ELISA and 2D-PAGE assays. © 2017 American Association for Clinical Chemistry.

  9. EFECTO DE DENSIDAD POBLACIONAL DE HUEVOS SOBRE VIABILIDAD Y TIEMPO DE DESARROLLO DE Drosophila melanogaster (DROSOPHILIDAE

    Directory of Open Access Journals (Sweden)

    CRISTIAN FONG

    2008-05-01

    Full Text Available Para estimar el efecto de la densidad poblacional de huevos sobre la viabilidad huevoadulto de Drosophila melanogaster se realizaron tres tratamientos en frascos con medio de cultivo agar-banano: a densidad de 10, 50 y 90 huevos. La variable de respuesta fue la proporción de individuos adultos emergidos desde la aparición del primer imago hasta 15 días después de la siembra. Las viabilidades huevo-adulto promedio fueron 0,320, 0,338 y 0,328 para las densidades de 10, 50 y 90 huevos respectivamente. No se evidenciaron diferencias significativas entre los tres tratamientos (p>0.05. Por lo tanto, no se detectó en este estudio influencia de la densidad poblacional de huevos sobre la viabilidad huevo-adulto. Probablemente debido a que la proporción entre el número de huevos y la cantidad de medio fue suficientemente alta para no generar competencia en otros estadios del desarrollo huevo/adulto.

  10. 75 FR 23263 - Alta Wind I, LLC; Alta Wind II, LLC; Alta Wind III, LLC; Alta Wind IV, LLC; Alta Wind V, LLC...

    Science.gov (United States)

    2010-05-03

    ...; Alta Wind VII, LLC; Alta Wind VIII, LLC; Alta Windpower Development, LLC; TGP Development Company, LLC... Development, LLC, and TGP Development Company, LLC (Petitioners) filed jointly a petition for declaratory...

  11. Estonia's Alta buys Lauma lingerie

    Index Scriptorium Estoniae

    2004-01-01

    Eesti investeeringute firma Alta Capital ostis 76,4 protsenti pesutootja Lauma aktsiatest. Tulevikus plaanitakse suunduda Ida- ja Lääne-Euroopa turgudele. Alta Capital omab 79 protsenti Klementi aktsiatest

  12. A Closer Look at Cardioprotective Function of HDL: Revise the HDL – Cholesterol Hypothesis?

    Directory of Open Access Journals (Sweden)

    Anna Meiliana

    2014-04-01

    Full Text Available BACKGROUND: The strong inverse association of plasma levels of high-density lipoprotein (HDL cholesterol with coronary heart disease (CHD found in human epidemiological studies led to the development of the ‘HDL cholesterol hypothesis’, which posits that intervention to raise HDL cholesterol will result in reduced risk of CHD. A number of recent developments have brought the potential protective role of HDL into question. Several clinical trials of agents that substantially raise HDL-C have been demonstrated to not reduce CHD event rates. CONTENT: For decades, HDL and HDL-cholesterol (HDL-C levels were viewed as synonymous, and modulation of HDL-C levels by drug therapy held great promise for the prevention and treatment of cardiovascular disease. Nevertheless, recent failures of drugs that raise HDL-C to reduce cardiovascular risk and the now greater understanding of the complexity of HDL composition and biology have prompted researchers in the field to redefine HDL. As such, the focus of HDL has now started to shift away from a cholesterol-centric view toward HDL particle number, subclasses, and other alternative metrics of HDL. Many of the recently discovered functions of HDL are, in fact, not strictly conferred by its ability to promote cholesterol flux but by the other molecules it transports, including a diverse set of proteins, small RNAs, hormones, carotenoids, vitamins, and bioactive lipids. Based on HDL’s ability to interact with almost all cells and deliver fat-soluble cargo, HDL has the remarkable capacity to affect a wide variety of endocrine-like systems. SUMMARY: There is a significant need to redefine HDL and its benefit. HDL transports a diverse set of functional proteins, including many binding proteins. HDL transports and deliver vitamins, carotenoids, and other small molecules. Moreover, HDL transports hormones, steroids and bile acids, and can modulate multiple endocrine pathways. HDLs also transport and deliver micro

  13. Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL Function.

    Science.gov (United States)

    Millar, Courtney L; Duclos, Quinn; Blesso, Christopher N

    2017-03-01

    Strong experimental evidence confirms that HDL directly alleviates atherosclerosis. HDL particles display diverse atheroprotective functions in reverse cholesterol transport (RCT), antioxidant, anti-inflammatory, and antiapoptotic processes. In certain inflammatory disease states, however, HDL particles may become dysfunctional and proatherogenic. Flavonoids show the potential to improve HDL function through their well-documented effects on cellular antioxidant status and inflammation. The aim of this review is to summarize the basic science and clinical research examining the effects of dietary flavonoids on RCT and HDL function. Based on preclinical studies that used cell culture and rodent models, it appears that many flavonoids (e.g., anthocyanidins, flavonols, and flavone subclasses) influence RCT and HDL function beyond simple HDL cholesterol concentration by regulating cellular cholesterol efflux from macrophages and hepatic paraoxonase 1 expression and activity. In clinical studies, dietary anthocyanin intake is associated with beneficial changes in serum biomarkers related to HDL function in a variety of human populations (e.g., in those who are hyperlipidemic, hypertensive, or diabetic), including increased HDL cholesterol concentration, as well as HDL antioxidant and cholesterol efflux capacities. However, clinical research on HDL functionality is lacking for some flavonoid subclasses (e.g., flavanols, flavones, flavanones, and isoflavones). Although there has been a tremendous effort to develop HDL-targeted drug therapies, more research is warranted on how the intake of foods or specific nutrients affects HDL function. © 2017 American Society for Nutrition.

  14. HDL function is impaired in acute myocardial infarction independent of plasma HDL cholesterol levels

    NARCIS (Netherlands)

    Annema, Wijtske; Willemsen, Hendrik M.; de Boer, Jan Freark; Dikkers, Arne; van der Giet, Markus; Nieuwland, Wybe; Muller Kobold, Anna; van Pelt, L. Joost; Slart, Riemer H. J. A.; van der Horst, Iwan C. C.; Dullaart, Robin P. F.; Tio, Rene A.; Tietge, Uwe J. F.

    2016-01-01

    BACKGROUND: High-density lipoproteins (HDLs) protect against the development of atherosclerotic cardiovascular disease. HDL function represents an emerging concept in cardiovascular research. OBJECTIVE: This study investigated the association between HDL functionality and acute myocardial infarction

  15. Niacin to Boost Your HDL "Good" Cholesterol

    Science.gov (United States)

    Niacin can boost 'good' cholesterol Niacin is a B vitamin that may raise your HDL ("good") cholesterol. But side effects might outweigh benefits for most ... been used to increase high-density lipoprotein (HDL) cholesterol — the "good" cholesterol that helps remove low-density ...

  16. Hepatic Proprotein Convertases Modulate HDL Metabolism

    Science.gov (United States)

    Jin, Weijun; Wang, Xun; Millar, John S.; Quertermous, Thomas; Rothblat, George H.; Glick, Jane M.; Rader, Daniel J.

    2007-01-01

    SUMMARY The risk of atherosclerosis is inversely associated with plasma levels of high-density lipoprotein cholesterol (HDL-C). However, HDL metabolism is incompletely understood, and there are few effective approaches to modulate HDL-C levels. Here we show that inhibition in the liver of the classical proprotein convertases (PCs), but not the atypical PCs S1P and PCSK9, decreases plasma HDL-C levels. This metabolic effect of hepatic PCs is critically dependent on expression of endothelial lipase (EL), an enzyme that directly hydrolyzes HDL phospholipids and promotes its catabolism. Hepatic PCs reduce EL function through direct inactivating cleavage of EL as well as through activating cleavage of angiopoietin-like protein 3 (ANGPTL3), an endogenous inhibitor of EL. Thus, inhibition of hepatic PCs results in increased EL activity, leading to reduced HDL-C as well as impaired reverse cholesterol transport. The hepatic PC-ANGPTL3-EL-HDL pathway is therefore a novel mechanism controlling HDL metabolism and cholesterol homeostasis. PMID:17681148

  17. High density lipoprotein (HDL) metabolism in noninsulin-dependent diabetes mellitus: measurement of HDL turnover using tritiated HDL

    Energy Technology Data Exchange (ETDEWEB)

    Golay, A.; Zech, L.; Shi, M.Z.; Chiou, Y.A.; Reaven, G.M.; Chen, Y.D.

    1987-09-01

    High density lipoprotein (HDL) kinetics were studied by injecting (/sup 3/H)apoprotein A-I (apoA-I)/HDL into 12 subjects with normal glucose tolerance and 12 patients with noninsulin-dependent diabetes mellitus (NIDDM). The results indicate that the mean fractional catabolic rate (FCR) of apoA-I/HDL was significantly faster (0.63 +/- 0.07 (+/- SEM) vs. 0.39 +/- 0.02 1/day; P less than 0.001) and the apoA-I/HDL synthetic rate greater (29.4 +/- 2.9 vs. 22.9 +/- 1.3 mg/kg X day; P less than 0.02) in patients with NIDDM than in normal subjects. Furthermore, there were statistically significant inverse relationships between apoA-I/HDL FCR and plasma levels of both HDL cholesterol (r = -0.71; P less than 0.001) and apoA-I (r = -0.63; P less than 0.001). In addition, the increase in apoA-I/HDL FCR was directly related to fasting plasma glucose (r = 0.78; P less than 0.001) and insulin (r = 0.76; P less than 0.001) concentrations. These data support the view that the decrease in plasma HDL cholesterol and apoA-I levels commonly found in patients with noninsulin-dependent diabetes is due to an increase in the catabolic rate of apoA-I/HDL secondary to the defects in carbohydrate metabolism present in these patients.

  18. High density lipoprotein (HDL) metabolism in noninsulin-dependent diabetes mellitus: measurement of HDL turnover using tritiated HDL

    International Nuclear Information System (INIS)

    Golay, A.; Zech, L.; Shi, M.Z.; Chiou, Y.A.; Reaven, G.M.; Chen, Y.D.

    1987-01-01

    High density lipoprotein (HDL) kinetics were studied by injecting [ 3 H]apoprotein A-I (apoA-I)/HDL into 12 subjects with normal glucose tolerance and 12 patients with noninsulin-dependent diabetes mellitus (NIDDM). The results indicate that the mean fractional catabolic rate (FCR) of apoA-I/HDL was significantly faster [0.63 +/- 0.07 (+/- SEM) vs. 0.39 +/- 0.02 1/day; P less than 0.001] and the apoA-I/HDL synthetic rate greater (29.4 +/- 2.9 vs. 22.9 +/- 1.3 mg/kg X day; P less than 0.02) in patients with NIDDM than in normal subjects. Furthermore, there were statistically significant inverse relationships between apoA-I/HDL FCR and plasma levels of both HDL cholesterol (r = -0.71; P less than 0.001) and apoA-I (r = -0.63; P less than 0.001). In addition, the increase in apoA-I/HDL FCR was directly related to fasting plasma glucose (r = 0.78; P less than 0.001) and insulin (r = 0.76; P less than 0.001) concentrations. These data support the view that the decrease in plasma HDL cholesterol and apoA-I levels commonly found in patients with noninsulin-dependent diabetes is due to an increase in the catabolic rate of apoA-I/HDL secondary to the defects in carbohydrate metabolism present in these patients

  19. Densidad y anatomia de la madera en familias mejoradas de sauces en Argentina

    Directory of Open Access Journals (Sweden)

    Silvia Monteoliva

    2013-12-01

    Full Text Available El objetivo del trabajo fue la evaluación de densidad y anatomía de la madera en siete familias de sauces, con vistas a seleccionar clones aptos para la producción de madera para usos sólidos y papel. Se cruzaron progenitores de cinco especies de sauces (S. babylonica, S. alba, S. nigra, S. amygdaloides y S. matsudana, obteniéndose 1800 individuos producto de cruzamientos controlados y polinización abierta, dentro del programa de mejoramiento de sauces del INTA. A los 34 meses se efectuó una primera selección por criterios de crecimiento, sanidad y forma. De esta primera fase de mejoramiento se seleccionaron 218 genotipos sobre los cuales se evaluaron las características anatómicas cuantitativas y la densidad de la madera. Los resultados indican que ninguna familia presenta buenos resultados en todas las propiedades. En una selección priorizando el vigor, la familia 08.09 presentó las siguientes características: buen crecimiento en diámetro (6,1 cm, fibras largas y de pared gruesa (850 µm y 2,22 µm, pocos vasos (94.mm-2 y densidad intermedia a baja (350 kg.m-3. Priorizando el rendimiento, material fibroso e indirectamente la resistencia, las familias 08.01 y 08.07 presentaron: densidad relativamente alta (403 - 397 kg.m-3, fibras largas (836 - 864 µm, vasos pequeños (46 - 45 µm y bajo crecimiento en diámetro (3 - 2,85 cm. Los cruzamientos donde intervienen las especies Salix nigra, S. amygdaloides y S. matsudana se destacaron ya que presentan buenos crecimientos y las mejores combinaciones xilológicas para diferentes destinos industriales.

  20. Anion exchange HPLC isolation of high-density lipoprotein (HDL and on-line estimation of proinflammatory HDL.

    Directory of Open Access Journals (Sweden)

    Xiang Ji

    Full Text Available Proinflammatory high-density lipoprotein (p-HDL is a biomarker of cardiovascular disease. Sickle cell disease (SCD is characterized by chronic states of oxidative stress that many consider to play a role in forming p-HDL. To measure p-HDL, apolipoprotein (apo B containing lipoproteins are precipitated. Supernatant HDL is incubated with an oxidant/LDL or an oxidant alone and rates of HDL oxidation monitored with dichlorofluorescein (DCFH. Although apoB precipitation is convenient for isolating HDL, the resulting supernatant matrix likely influences HDL oxidation. To determine effects of supernatants on p-HDL measurements we purified HDL from plasma from SCD subjects by anion exchange (AE chromatography, determined its rate of oxidation relative to supernatant HDL. SCD decreased total cholesterol but not triglycerides or HDL and increased cell-free (cf hemoglobin (Hb and xanthine oxidase (XO. HDL isolated by AE-HPLC had lower p-HDL levels than HDL in supernatants after apoB precipitation. XO+xanthine (X and cf Hb accelerated purified HDL oxidation. Although the plate and AE-HPLC assays both showed p-HDL directly correlated with cf-Hb in SCD plasma, the plate assay yielded p-HDL data that was influenced more by cf-Hb than AE-HPLC generated p-HDL data. The AE-HPLC p-HDL assay reduces the influence of the supernatants and shows that SCD increases p-HDL.

  1. HDL (Good), LDL (Bad) Cholesterol and Triglycerides

    Science.gov (United States)

    ... be measured by a blood test. LDL (Bad) Cholesterol LDL cholesterol is called “bad” cholesterol. Think of it ... A high triglyceride level combined with low HDL cholesterol or high LDL cholesterol is linked with fatty buildups in artery ...

  2. Estudio transversal sobre estilos de vida saludable y su relación con el colesterol HDL en la población adulta

    Directory of Open Access Journals (Sweden)

    Héctor E. Palmett-Ríos

    2017-09-01

    Conclusión: Los bajos niveles de colesterol HDL tienen alta prevalencia en población adulta de Medellín y se requieren políticas administrativas y de salud pública que promuevan estilos de vida saludable para modificarlos.

  3. Computer arithmetic and verilog HDL fundamentals

    CERN Document Server

    Cavanagh, Joseph

    2009-01-01

    Verilog Hardware Description Language (HDL) is the state-of-the-art method for designing digital and computer systems. Ideally suited to describe both combinational and clocked sequential arithmetic circuits, Verilog facilitates a clear relationship between the language syntax and the physical hardware. It provides a very easy-to-learn and practical means to model a digital system at many levels of abstraction. Computer Arithmetic and Verilog HDL Fundamentals details the steps needed to master computer arithmetic for fixed-point, decimal, and floating-point number representations for all prima

  4. HDL in sepsis - risk factor and therapeutic approach

    Directory of Open Access Journals (Sweden)

    Emily E Morin

    2015-10-01

    Full Text Available High-density lipoprotein (HDL is a key component of circulating blood and plays essential roles in regulation of vascular endothelial function and immunity. Clinical data demonstrate that HDL levels drop by 40-70% in septic patients, which is associated with a poor prognosis. Experimental studies using Apolipoprotein A-I (ApoAI null mice as an HDL deficient model showed that mice lacking HDL are susceptible to septic death, and overexpressing ApoAI in mice to increase HDL levels protects against septic death. These clinical and animal studies support our hypothesis that a decrease in HDL level is a risk factor for sepsis, and raising circulating HDL levels may provide an efficient therapy for sepsis. In this review, we discuss the roles of HDL in sepsis and summarize the efforts of using synthetic HDL as a potential therapy for sepsis.

  5. Altas capacidades en el aula /

    OpenAIRE

    Conesa Muñoz., María Gregoria

    2014-01-01

    Las altas capacidades necesitan un tratamiento específico, del mismo modo que lo necesitan otros alumnos con dificultades para el aprendizaje, el hecho de que les sea más fácil aprender no significa que no se deban potenciar sus capacidades. Se analiza el tratamiento que han tenido las altas capacidades intelectuales a lo largo de los diferentes sistemas educativos, se ven las características más importantes que pueden tener estos niños y las diferentes vías de identificación y diagnóstico. ...

  6. Large-Scale Candidate Gene Analysis of HDL Particle Features

    Science.gov (United States)

    Kaess, Bernhard M.; Tomaszewski, Maciej; Braund, Peter S.; Stark, Klaus; Rafelt, Suzanne; Fischer, Marcus; Hardwick, Robert; Nelson, Christopher P.; Debiec, Radoslaw; Huber, Fritz; Kremer, Werner; Kalbitzer, Hans Robert; Rose, Lynda M.; Chasman, Daniel I.; Hopewell, Jemma; Clarke, Robert; Burton, Paul R.; Tobin, Martin D.

    2011-01-01

    Background HDL cholesterol (HDL-C) is an established marker of cardiovascular risk with significant genetic determination. However, HDL particles are not homogenous, and refined HDL phenotyping may improve insight into regulation of HDL metabolism. We therefore assessed HDL particles by NMR spectroscopy and conducted a large-scale candidate gene association analysis. Methodology/Principal Findings We measured plasma HDL-C and determined mean HDL particle size and particle number by NMR spectroscopy in 2024 individuals from 512 British Caucasian families. Genotypes were 49,094 SNPs in >2,100 cardiometabolic candidate genes/loci as represented on the HumanCVD BeadChip version 2. False discovery rates (FDR) were calculated to account for multiple testing. Analyses on classical HDL-C revealed significant associations (FDRparticle size yielded additional associations in LIPC (hepatic lipase; rs261332: p = 6.1*10−9), PLTP (phospholipid transfer protein, rs4810479: p = 1.7*10−8) and FBLN5 (fibulin-5; rs2246416: p = 6.2*10−6). The associations of SGCD and Fibulin-5 with HDL particle size could not be replicated in PROCARDIS (n = 3,078) and/or the Women's Genome Health Study (n = 23,170). Conclusions We show that refined HDL phenotyping by NMR spectroscopy can detect known genes of HDL metabolism better than analyses on HDL-C. PMID:21283740

  7. Efecto del color y de la densidad del polietileno de fundas para cubrir el racimo sobre dimensiones, presentación y calidad poscosecha de frutos de banano y plátano

    Directory of Open Access Journals (Sweden)

    Alfonso Vargas

    2010-01-01

    Full Text Available Se evaluó el efecto del color (azul, verde y rojo y densidad (baja y alta del polietileno de fundas protectoras del racimo de Musa en 4 experimentos de banano (Musa AAA y en 1 de plátano (Musa AAB realizados en fincas comerciales del Caribe de Costa Rica. El peso del racimo y el intervalo de días del embolse a la cosecha no difirieron entre los colores (p>0,4116 ni entre las densidades (p>0,2583 de las fundas. La apariencia del racimo presentó diferencias entre colores (p0,0669 y densidades (p>0,2370 de las fundas. La longitud del fruto central de las manos antes mencionadas tampoco presentó diferencias entre colores (p>0,1446 y solo varió con la densidad en la segunda y cuarta mano del experimento 3 (p0,0899 y entre las densidades (p>0,0606 de las fundas. El porcentaje de acidez presentó diferencias (p<0,0001 entre colores solamente en el experimento 1. Los resultados indican que generalmente, bajo las condiciones agroclimáticas y de manejo propias de Caribe costarricense, no hubo efecto del color ni de la densidad del polietileno evaluados sobre los racimos y frutos de banano y plátano.

  8. Verilog HDL digital design and modeling

    CERN Document Server

    Cavanagh, Joseph

    2007-01-01

    PREFACE INTRODUCTION History of HDL Verilog HDL IEEE Standard Features Assertion Levels OVERVIEW Design Methodologies Modulo-16 Synchronous Counter Four-Bit Ripple Adder Modules and Ports Designing a Test Bench for Simulation Construct Definitions Introduction to Dataflow Modeling Two-Input Exclusive-OR Gate Four 2-Input AND Gates With Delay Introduction to Behavioral Modeling Three-Input OR Gate Four-Bit Adder Modulo-16 Synchronous Counter Introduction to Structural Modeling Sum-of-Products Implementation Full Adder Four-Bit Ripple Adder Introduction to Mixed-Design Modeling Full Adder Problems LANGUAGE ELEMENTS Comments Identifiers Keywords Bidirectional Gates Charge Storage Strengths CMOS Gates Combinational Logic Gates Continuous Assignment Data Types Module Declaration MOS Switches Multiple-Way Branching Named Ev...

  9. [Therapeutic targets in the treatment of dyslipidemia: HDL and non-HDL cholesterol].

    Science.gov (United States)

    Brea Hernando, Ángel Julián

    2014-07-01

    Atherogenic dyslipidemia (AD) consists of the combination of an increase in very low density lipoproteins (VLDL), which results in increased plasma triglyceride (TG) levels, with a reduction of levels of high-density lipoprotein bound cholesterol (HDL-C), also accompanied by a high proportion of small and dense LDL particles. AD is considered the main cause of the residual risk of experiencing cardiovascular disease (CVD), which is still presented by any patient on treatment with statins despite maintaining low-density lipoprotein bound cholesterol (LDL-C) levels below the values considered to be the objective. Non-HDL cholesterol (non-HDL-c) reflects the number of atherogenic particles present in the plasma. This includes VLDL, intermediate density lipoproteins (IDL) and LDL. Non-HDL-c provides a better estimate of cardiovascular risk than LDL-c, especially in the presence of hypertriglyceridemia or AD. The European guidelines for managing dyslipidemia recommend that non-HDL-c values be less than 100 and 130 mg/dL for individuals with very high and high cardiovascular risk, respectively. However, these guidelines state that there is insufficient evidence to suggest that raising HDL-c levels incontrovertibly results in a reduction in CVD. Therefore, the guidelines do not set recommended HDL-c levels as a therapeutic objective. The guidelines, however, state that individuals with AD on treatment with statins could benefit from an additional reduction in their risk by using fibrates. Copyright © 2014 Sociedad Española de Arteriosclerosis y Elsevier España, S.L. All rights reserved.

  10. High pre-beta1 HDL concentrations and low lecithin: cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol

    DEFF Research Database (Denmark)

    Sethi, Amar A; Sampson, Maureen; Warnick, Russell

    2010-01-01

    We hypothesized that patients with high HDL-cholesterol (HDL-C) and ischemic heart disease (IHD) may have dysfunctional HDL or unrecognized nonconventional risk factors.......We hypothesized that patients with high HDL-cholesterol (HDL-C) and ischemic heart disease (IHD) may have dysfunctional HDL or unrecognized nonconventional risk factors....

  11. Genetics of HDL-C: a causal link to atherosclerosis?

    NARCIS (Netherlands)

    van Capelleveen, Julian C.; Bochem, Andrea E.; Motazacker, M. Mahdi; Hovingh, G. Kees; Kastelein, John J. P.

    2013-01-01

    Prospective epidemiological studies have consistently reported an inverse association between HDL cholesterol (HDL-C) levels and the risk of cardiovascular disease (CVD). However, large intervention trials on HDL-C-increasing drugs and recent Mendelian randomization studies have questioned a causal

  12. Digital design and verilog HDL fundamentals

    CERN Document Server

    Cavanagh, Joseph

    2011-01-01

    Comprehensive and self contained, this tutorial covers the design of a plethora of combinational and sequential logic circuits using conventional logic design and Verilog HDL. Number systems and number representations are presented along with various binary codes. Several advanced topics are covered, including functional decomposition and iterative networks. A variety of examples are provided for combinational and sequential logic, computer arithmetic, and advanced topics such as Hamming code error correction. Constructs supported by Verilog are described in detail. All designs are continued to completion. Each chapter includes numerous design issues of varying complexity to be resolved by the reader.

  13. Therapeutic applications of reconstituted HDL: When structure meets function.

    Science.gov (United States)

    Darabi, Maryam; Guillas-Baudouin, Isabelle; Le Goff, Wilfried; Chapman, M John; Kontush, Anatol

    2016-01-01

    Reconstituted forms of HDL (rHDL) are under development for infusion as a therapeutic approach to attenuate atherosclerotic vascular disease and to reduce cardiovascular risk following acute coronary syndrome and ischemic stroke. Currently available rHDL formulations developed for clinical use contain apolipoprotein A-I (apoA-I) and one of the major lipid components of HDL, either phosphatidylcholine or sphingomyelin. Recent data have established that quantitatively minor molecular constituents of HDL particles can strongly influence their anti-atherogenic functionality. Novel rHDL formulations displaying enhanced biological activities, including cellular cholesterol efflux, may therefore offer promising prospects for the development of HDL-based, anti-atherosclerotic therapies. Indeed, recent structural and functional data identify phosphatidylserine as a bioactive component of HDL; the content of phosphatidylserine in HDL particles displays positive correlations with all metrics of their functionality. This review summarizes current knowledge of structure-function relationships in rHDL formulations, with a focus on phosphatidylserine and other negatively-charged phospholipids. Mechanisms potentially underlying the atheroprotective role of these lipids are discussed and their potential for the development of HDL-based therapies highlighted. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. HDL Cholesterol and Risk of Type 2 Diabetes

    DEFF Research Database (Denmark)

    Haase, Christiane L; Tybjærg-Hansen, Anne; Nordestgaard, Børge G

    2015-01-01

    Observationally, low levels of HDL cholesterol are consistently associated with increased risk of type 2 diabetes. Therefore, plasma HDL cholesterol increasing has been suggested as a novel therapeutic option to reduce the risk of type 2 diabetes. Whether levels of HDL cholesterol are causally...... associated with type 2 diabetes is unknown. In a prospective study of the general population (n = 47,627), we tested whether HDL cholesterol-related genetic variants were associated with low HDL cholesterol levels and, in turn, with an increased risk of type 2 diabetes. HDL cholesterol-decreasing gene scores...... and allele numbers associated with up to -13 and -20% reductions in HDL cholesterol levels. The corresponding theoretically predicted hazard ratios for type 2 diabetes were 1.44 (95% CI 1.38-1.52) and 1.77 (1.61-1.95), whereas the genetic estimates were nonsignificant. Genetic risk ratios for type 2 diabetes...

  15. Ajuste do modelo de Reineke para estimativa da linha de máxima densidade na Floresta Estacional Decidual no Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Evandro Alcir Meyer

    2013-08-01

    Full Text Available O objetivo deste trabalho foi estudar a relação entre a densidade de árvores por hectare e o diâmetro médio de uma Floresta Estacional Decidual, bem como ajustar o modelo Reineke para descrever esse comportamento, comparando o desempenho de diferentes métodos. A área de estudo localiza-se no Município de Silveira Martins, na região central do Rio Grande do Sul, e encontra-se em estágio inicial de sucessão, após o uso agrícola. As informações referentes ao número de árvores por hectare e ao diâmetro médio foram obtidas por meio do método de densidade pontual proposto por Spurr. As amostras foram tomadas nos estágios iniciais de uma floresta secundária, escolhendo-se áreas onde predominava o camboatá-vermelho (Cupania vernalis. Como as florestas naturais apresentam espaçamento irregular, a densidade é bastante variável. Assim, para selecionar apenas parcelas em alta densidade, foram escolhidas áreas onde se verificava a ocorrência de indivíduos mortos. Foram testados diferentes métodos para estimar o limite superior da linha de autodesbaste: a análise de regressão (para todos os dados e densidade relativa maior que 60%, corrigindo o intercepto para que os resíduos fossem negativos; o ajuste manual; o de densidade relativa (DR>90%; e a análise de fronteira estocástica. O método que melhor estimou a máxima densidade foi a análise de regressão com dados de no mínimo 60% da densidade máxima, obtendo-se um coeficiente angular de -1,563 para o modelo de Reineke. Não houve diferença significativa entre as potências fornecidas pelos diferentes métodos.

  16. Densidad mamaria y riesgo de cáncer mamario

    Directory of Open Access Journals (Sweden)

    V. Paulina Neira, Dra.

    2013-01-01

    Full Text Available La densidad mamaria, medida a través de la mamografía, es un importante factor de riesgo para cáncer mamario, independientemente del ocultamiento de lesiones producido por el aumento de la densidad mamaria en la mamografía. Hay diferentes métodos para medir la densidad mamaria, siendo el más frecuente en su uso la clasificación BI-RADS, aunque las mediciones con asistencia de computador son más confiables. De todos modos los diferentes métodos de medición en uso tienen limitaciones que probablemente disminuyen la real asociación con cáncer mamario. Se han descrito diferentes factores que influyen en la densidad mamaria entre los cuáles se encuentra la edad, peso, factores hormonales y herencia principalmente. Hay un potencial uso de la densidad mamaria, en la clínica y prevención, pero es necesario mejorar su medición para que pueda ser útil como un predictor individual.

  17. Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and coronary artery disease

    Directory of Open Access Journals (Sweden)

    Uint Luciana

    2003-01-01

    Full Text Available OBJECTIVE: The aim of this study was to verify whether HDL particles isolated from patients with coronary artery disease (CAD and low HDL-C had diminished ability to promote cholesterol efflux from cultured cells compared with HDL isolated from subjects without CAD and with normal HDL-C. METHODS: Smooth muscle cells isolated from human aortas cultured and radiolabeled with ³H-cholesterol were loaded with cholesterol and incubated with increasing concentrations of HDL isolated from 13 CAD patients with low HDL-C (CAD group or from 5 controls without CAD (C group. Efflux of cellular cholesterol was measured by cellular depletion of radiolabeled cholesterol and by the appearance of ³H-cholesterol into experimental medium expressed as a percentage of total labeled cholesterol. RESULTS: Cholesterol efflux increased with the amount of HDL present in the medium, and no difference was found between groups at various HDL protein concentrations: efflux was 28 ± 6.3% (C and 25.5 ± 8.9% (CAD with 25 mg/mL; 34 ± 4.3% (C and 31.9 ± 6.6% (CD with 50 mg/mL and 39.5 ± 3.5% (C and 37.1 ± 4.4% (CAD with 100 mg/mL, HDL. CONCLUSION: Because the HDL fraction of CAD patients with low HDL-C have normal ability to extract cholesterol from cells of the vessel wall, it is suggested that low HDL-C atherogenicity should be ascribed to diminished concentrations of HDL particles rather than to the qualitative properties of the HDL fraction.

  18. Nanoheteroestructuras de GaAs/AlGaAs. Simulación y aplicación en transistores de alta movilidad

    Directory of Open Access Journals (Sweden)

    Eduardo Martín Rodríguez

    2011-01-01

    Los transistores de alta movilidad (HEMT, High Electron Mobility Transistor son una de las aplicaciones más importantes de las propiedades de las heteroestructuras, con frecuencias de trabajo en el rango de 30 a 300 GHz. La simulación de un ejemplo de estos transistores es presentada en este trabajo, lográndose una densidad de corriente máxima en el canal de 1 A/mm2 comparable con resultados reportados para transistores similares.

  19. La calidad de la densidad urbana en Bogotá

    Directory of Open Access Journals (Sweden)

    Óscar Alfonso Roa

    2016-06-01

    Full Text Available Para alojar a la creciente población de Bogotá, desde mediados del siglo pasado se prefiere aumentar la densidad en zonas residenciales que la expansión metropolitana. En este artículo se hace un análisis de la ocupación del perímetro bogotano que no se limita a los gradientes de densidad sino que integra medidas de su calidad que captan la desigualdad en materia de densidad, dotación pública, espacios libres y mezcla social. El índice resultante es una medida alternativa de la segregación socio-espacial.

  20. ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level

    Directory of Open Access Journals (Sweden)

    Kexiu Song

    2014-01-01

    Full Text Available HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved. Ectopic ATP synthase β-chain in hepatocytes has been previously characterized as an apoA-I receptor, triggering HDL internalization. This study was undertaken to identify the overexpression of ectopic ATP synthase β-chain on DIL-HDL uptake in primary hepatocytes in vitro and on plasma HDL levels in SR-BI knockout mice. Human ATP synthase β-chain cDNA was delivered to the mouse liver by adenovirus and GFP adenovirus as control. The adenovirus-mediated overexpression of β-chain was identified at both mRNA and protein levels on mice liver and validated by its increasing of DiL-HDL uptake in primary hepatocytes. In response to hepatic overexpression of β-chain, plasma HDL-C levels and cholesterol were reduced in SR-BI knockout mice, compared with the control. The present data suggest that ATP synthase β-chain can serve as the endocytic receptor of HDL, and its overexpression can reduce plasma HDL-C.

  1. New drugs for HDL-C disorders: the beginning.

    Science.gov (United States)

    Duong, MyNgan; Nicholls, Stephen J

    2014-01-01

    For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.

  2. Liga de magnésio como material para bateria de alta densidade energética

    OpenAIRE

    Munhoz, Igor Polezi

    2014-01-01

    Orientador: Prof. Dr. Jorge Tomioka Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Engenharia Elétrica, 2014. No contexto energético, as mudanças climáticas e as crescentes crises energéticas aumentaram as preocupações e as pesquisas na área de acumuladores de energia, visando alcançar melhorias no cenário energético e ambiental global. Ao mesmo tempo, a sociedade tornou-se dependente do consumo de energia elétrica, sendo que falhas no fornec...

  3. Appraisal of a HDPE internal liner; Avaliacao de revestimento interno de duto em polietileno de alta densidade

    Energy Technology Data Exchange (ETDEWEB)

    Meniconi, Luiz C.M.; Perrut, Valber A.; Castellares, Lizabeth G. [PETROBRAS, Rio de Janeiro, RJ (Brazil). Centro de Pesquisas (CENPES); Medeiros, Raimundo C. [PETROBRAS, SP (Brazil). Setor de Qualificacao e Certificacao (SEQUI)

    2005-07-01

    The mechanical properties of a high density polyethylene were evaluated by tensile and tearing tests, after ageing for up to 28 days of immersion in crude oil at 55 deg C. After that, the performance of the polymer as a liner of a metallic pipeline was appraised. A situation was simulated in which an infinitely long defect was supposed to exist along the inner bottom of the pipeline, due to pitting corrosion. Under internal pressure, the liner is pushed and bent against the empty space behind it, causing a tensile stress on its outer surface. The abrasion between the liner and the pipeline during liner installation can create scratches in the liner. The scratches would behave as notches for the initiation of a propagating defect, under the tensile load mentioned above. Finite Element Modeling was used to define the limit values of internal pressure, liner thickness and defect size that would cause defect propagation. The simulation was performed for typical values of pipeline diameter, defect size and liner thickness. (author)

  4. ApoE-containing HDL and the development of atherosclerosis

    Directory of Open Access Journals (Sweden)

    Zbigniew Zdrojewski

    2015-06-01

    Full Text Available The current state of knowledge about the role of high density lipoproteins (HDL indicates that their anti-atherogenic function is mainly related to the effectiveness of their actions (mostly to the participation in reverse cholesterol transport from tissues to liver rather than the concentration of HDL itself. HDLs are highly heterogeneous in their structure, lipid and protein composition and metabolic pathways and individual HDL subpopulations differ in their biological activity and effectiveness of anti-atherogenic actions. Apolipoproteins play a key role in HDL metabolism, therefore their presence in lipoproteins is one of the main criterion for HDL classification. According to this criterion HDLs containing apolipoprotein E, called HDL-apoE, are distinguished. Although the anti-atherogenic role of apo E has been demonstrated in many scientific reports, understanding of the mechanisms of formation, transformation and the role of HDL-apoE is still the aim of intense research. The results of epidemiological studies are inconclusive; some of them have demonstrated that high HDL- -apoE concentration has been associated with lower risk of developing coronary heart disease (CHD, while other studies have shown that high levels of HDL-apoE has been an independent risk factor for cardiovascular events and positively correlated with other risk factors for CHD.

  5. La densidad urbana como variable de análisis de la ciudad: El caso de Cuenca, Ecuador

    Directory of Open Access Journals (Sweden)

    M. Augusta Hermida

    2015-09-01

    Full Text Available El debate teórico sobre la ciudad dispersa versus la ciudad compacta, en el mundo y particularmente en América Latina, pone en la palestra los aspectos clave necesarios para proponer un nuevo modelo de ciudad, donde la calidad de vida de las presentes y futuras generaciones sea el punto focal de reflexión. A través del estudio del estado del arte sobre el tema se concluye que el regreso a la ciudad compacta es la alternativa para un posible desarrollo sustentable en las ciudades intermedias de América Latina. En el caso de Cuenca, se concentra el estudio en las densidades de la ciudad desde los años cincuenta hasta nuestros días. Sorprende comprobar que Cuenca fue una ciudad compacta con alta calidad de vida pero que, paulatinamente, se está expandiendo innecesariamente, con todos los problemas que ello implica.

  6. Endothelial lipase is a major determinant of HDL level

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, Tatsuro; Choi, Sungshin; Kundu, Ramendra K.; Hirata, Ken-Ichi; Rubin, Edward M.; Cooper, Allen D.; Quertermous, Thomas

    2003-01-30

    For the past three decades, epidemiologic studies have consistently demonstrated an inverse relationship between plasma HDL cholesterol (HDL-C) concentrations and coronary heart disease (CHD). Population-based studies have provided compelling evidence that low HDL-C levels are a risk factor for CHD, and several clinical interventions that increased plasma levels of HDL-C were associated with a reduction in CHD risk. These findings have stimulated extensive investigation into the determinants of plasma HDL-C levels. Turnover studies using radiolabeled apolipoprotein A-I, the major protein component of HDL, suggest that plasma HDL-C concentrations are highly correlated with the rate of clearance of apolipoprotein AI. However, the metabolic mechanisms by which HDL are catabolized have not been fully defined. Previous studies in humans with genetic deficiency of cholesteryl ester transfer protein, and in mice lacking the scavenger receptor BI (SR-BI), have demonstrated that these proteins participate in the removal of cholesterol from HDL, while observations in individuals with mutations in hepatic lipase indicate that this enzyme hydrolyzes HDL triglycerides. In this issue of the JCI, reports from laboratories of Tom Quertermous and Dan Rader now indicate that endothelial lipase (LIPG), a newly identified member of the lipase family, catalyzes the hydrolysis of HDL phospholipids and facilitates the clearance of HDL from the circulation. Endothelial lipase was initially cloned by both of these laboratories using entirely different strategies. Quertermous and his colleagues identified endothelial lipase as a transcript that was upregulated in cultured human umbilical vein endothelial cells undergoing tube formation, whereas the Rader group cloned endothelial lipase as a transcript that was upregulated in the human macrophage-like cell line THP-1 exposed to oxidized LDL. Database searches revealed that endothelial lipase shows strong sequence similarity to lipoprotein

  7. Alta peab tasuma Kalevile mais / Kersti Saar

    Index Scriptorium Estoniae

    Saar, Kersti

    2008-01-01

    Indrek Rahumaa juhitav Alta Capital peab tasuma Oliver Kruudale Kalevi tütarfirmade eest 660 miljonit krooni hiljemalt 30. maiks. Vt. samas: Investorid teavad tehingu hinda ja lõplikku tähtaega. Diagramm: Kalevi turuväärtus jääb Alta müügihinnale alla

  8. TransAlta: More than a utility

    International Nuclear Information System (INIS)

    Mikalson, D.A.

    1991-01-01

    TransAlta Utilities Corporation is Canada's largest privately owned utility and is also a major coal mining company. In 1989, TransAlta produced 20.9% of all coal mined in Canada. A brief history of TransAlta is presented along with TransAlta's present coal operations and plans for the next three years. An overview is presented of how TransAlta Fuel Supply is organized to utilize contracted mining operation, engineering and environmental services and in-house capabilities. Recent strategic initiatives to improve organizational efficiency and the mining operations are discussed. These range from developing a common departmental vision to modifying major mining equipment. TransAlta's proactive role in clean coal combustion such as low NOx-SOx burner, integrated combined cycle gasification, and other energy research projects is reviewed. A summary is provided of recent participation of TransAlta in environmental management initiatives. Recent successes of TransAlta's unregulated subsidiary in the development of cogeneration facilities and the future of this area of business are discussed. 8 refs., 4 figs

  9. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

    Science.gov (United States)

    Huang, Ying; Wu, Zhiping; Riwanto, Meliana; Gao, Shengqiang; Levison, Bruce S.; Gu, Xiaodong; Fu, Xiaoming; Wagner, Matthew A.; Besler, Christian; Gerstenecker, Gary; Zhang, Renliang; Li, Xin-Min; DiDonato, Anthony J.; Gogonea, Valentin; Tang, W.H. Wilson; Smith, Jonathan D.; Plow, Edward F.; Fox, Paul L.; Shih, Diana M.; Lusis, Aldons J.; Fisher, Edward A.; DiDonato, Joseph A.; Landmesser, Ulf; Hazen, Stanley L.

    2013-01-01

    Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein–associated (HDL-associated) proteins mechanistically linked to inflammation, oxidant stress, and atherosclerosis. MPO is a source of ROS during inflammation and can oxidize apolipoprotein A1 (APOA1) of HDL, impairing its atheroprotective functions. In contrast, PON1 fosters systemic antioxidant effects and promotes some of the atheroprotective properties attributed to HDL. Here, we demonstrate that MPO, PON1, and HDL bind to one another, forming a ternary complex, wherein PON1 partially inhibits MPO activity, while MPO inactivates PON1. MPO oxidizes PON1 on tyrosine 71 (Tyr71), a modified residue found in human atheroma that is critical for HDL binding and PON1 function. Acute inflammation model studies with transgenic and knockout mice for either PON1 or MPO confirmed that MPO and PON1 reciprocally modulate each other’s function in vivo. Further structure and function studies identified critical contact sites between APOA1 within HDL, PON1, and MPO, and proteomics studies of HDL recovered from acute coronary syndrome (ACS) subjects revealed enhanced chlorotyrosine content, site-specific PON1 methionine oxidation, and reduced PON1 activity. HDL thus serves as a scaffold upon which MPO and PON1 interact during inflammation, whereupon PON1 binding partially inhibits MPO activity, and MPO promotes site-specific oxidative modification and impairment of PON1 and APOA1 function. PMID:23908111

  10. Reference intervals for serum total cholesterol, HDL cholesterol and ...

    African Journals Online (AJOL)

    Reference intervals of total cholesterol, HDL cholesterol and non-HDL cholesterol concentrations were determined on 309 blood donors from an urban and peri-urban population of Botswana. Using non-parametric methods to establish 2.5th and 97.5th percentiles of the distribution, the intervals were: total cholesterol 2.16 ...

  11. Hdl-Cholesterol Et Les Autres Facteurs De Risque Cardio ...

    African Journals Online (AJOL)

    Ceci permettra de corriger d'éventuelles dyslipidémies et de prévenir les maladies cardiovasculaires. Mots clés : HDL-Cholestérol, facteurs de risques cardiovasculaires, noir africain, Togo. Objectives: To determine the frequency of cardiovascular risk according to HDL-C in cardiac milieu in black Africa, assess the impact ...

  12. Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.

    Science.gov (United States)

    Bartelt, Alexander; John, Clara; Schaltenberg, Nicola; Berbée, Jimmy F P; Worthmann, Anna; Cherradi, M Lisa; Schlein, Christian; Piepenburg, Julia; Boon, Mariëtte R; Rinninger, Franz; Heine, Markus; Toedter, Klaus; Niemeier, Andreas; Nilsson, Stefan K; Fischer, Markus; Wijers, Sander L; van Marken Lichtenbelt, Wouter; Scheja, Ludger; Rensen, Patrick C N; Heeren, Joerg

    2017-04-19

    Brown and beige adipocytes combust nutrients for thermogenesis and through their metabolic activity decrease pro-atherogenic remnant lipoproteins in hyperlipidemic mice. However, whether the activation of thermogenic adipocytes affects the metabolism and anti-atherogenic properties of high-density lipoproteins (HDL) is unknown. Here, we report a reduction in atherosclerosis in response to pharmacological stimulation of thermogenesis linked to increased HDL levels in APOE*3-Leiden.CETP mice. Both cold-induced and pharmacological thermogenic activation enhances HDL remodelling, which is associated with specific lipidomic changes in mouse and human HDL. Furthermore, thermogenic stimulation promotes HDL-cholesterol clearance and increases macrophage-to-faeces reverse cholesterol transport in mice. Mechanistically, we show that intravascular lipolysis by adipocyte lipoprotein lipase and hepatic uptake of HDL by scavenger receptor B-I are the driving forces of HDL-cholesterol disposal in liver. Our findings corroborate the notion that high metabolic activity of thermogenic adipocytes confers atheroprotective properties via increased systemic cholesterol flux through the HDL compartment.

  13. Antioxidant activity of high-density lipoprotein (HDL) using different ...

    African Journals Online (AJOL)

    HDL is a potent antioxidant in terms of inhibition of lipid peroxidation, ROS production and LDL oxidation. These may to some extent add to the antiatherogenic beyond reverse-cholesterol transport properties of HDL. Keywords: high-density lipoprotein; reverse cholesterol transport; apolipoprotein A1; antioxidant; in vitro.

  14. HDL as a drug and nucleic acid delivery vehicle

    Directory of Open Access Journals (Sweden)

    Andras G Lacko

    2015-10-01

    Full Text Available This review is intended to evaluate the research findings and potential clinical applications of drug transport systems, developed based on the concepts of the structure/function and physiological role(s of high density lipoprotein=type nanoparticles. These macromolecules provide targeted transport of cholesteryl esters (a highly lipophilic payload in their natural/physiological environment. The property of accommodating highly water insoluble constituents in their core region enables HDL type nanoparticles to effectively transport hydrophobic drugs upon intravenous administration. Even though the application of reconstituted HDL in the treatment of a number of diseases is reviewed, the primary focus is on the application of HDL type drug delivery agents in cancer chemotherapy. The use of both native and synthetic HDL as drug delivery agents are compared to evaluate their respective potentials for commercial and clinical development. The current status and future perspectives for HDL type nanoparticles are discussed, including current obstacles and future applications in therapeutics.

  15. The pleiotropic role of HDL in autoimmune diseases.

    Science.gov (United States)

    Parra, Sandra; Castro, Antoni; Masana, Luis

    2015-01-01

    As is widely known, the classic function of HDL is reverse cholesterol transport (RCT), thus removing cholesterol from peripheral tissues. Early epidemiological studies, such as Framingham's, stated that increased HDL levels were associated with a significant decrease in relative risk for cardiovascular disease (CVD) mortality. However, those with heightened expectations in recent years for the development of therapeutic targets to increase HDL levels have been disappointed, because efforts have demonstrated the opposite effect on cardiovascular and global mortality. However, in contrast, studies have highlighted the complexity and the intriguing role of HDL in different pathological conditions, such as infections, neoplasms, and autoimmune diseases. In this review an attempt is made to summarize some biological pathways that link HDL function with the immune system, and its possible clinical repercussions in autoimmune diseases. Copyright © 2014 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

  16. Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome.

    Science.gov (United States)

    Rached, Fabiana; Santos, Raul D; Camont, Laurent; Miname, Marcio H; Lhomme, Marie; Dauteuille, Carolane; Lecocq, Sora; Serrano, Carlos V; Chapman, M John; Kontush, Anatol

    2014-12-01

    To evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q[-2]X, were recruited together with age- and sex-matched healthy controls (n = 11). Homozygotes displayed undetectable plasma levels of apoA-I and reduced levels of HDL-cholesterol (HDL-C) and apoC-III (5.4% and 42.6% of controls, respectively). Heterozygotes displayed low HDL-C (21 ± 9 mg/dl), low apoA-I (79 ± 24 mg/dl), normal LDL-cholesterol (132 ± 25 mg/dl), and elevated TG (130 ± 45 mg/dl) levels. Cholesterol efflux capacity of ultracentrifugally isolated HDL subpopulations was reduced (up to -25%, P < 0.01, on a glycerophospholipid [GP] basis) in heterozygotes versus controls. Small, dense HDL3 and total HDL from heterozygotes exhibited diminished antioxidative activity (up to -48%, P < 0.001 on a total mass basis) versus controls. HDL subpopulations from both homozygotes and heterozygotes displayed altered chemical composition, with depletion in apoA-I, GP, and cholesteryl ester; enrichment in apoA-II, free cholesterol, and TG; and altered phosphosphingolipidome. The defective atheroprotective activities of HDL were correlated with altered lipid and apo composition. These data reveal that atheroprotective activities of HDL particles are impaired in homozygous and heterozygous apoA-I deficiency and are intimately related to marked alterations in protein and lipid composition. Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.

  17. Autoimmune Lymphoproliferative Syndrome: A Rare Cause of Disappearing HDL Syndrome

    Directory of Open Access Journals (Sweden)

    Swetha Sriram

    2016-01-01

    Full Text Available The term disappearing HDL syndrome refers to development of severe high density lipoprotein cholesterol (HDL-C deficiency in noncritically ill patients with previously normal HDL-C and triglyceride levels. Autoimmune lymphoproliferative syndrome (ALPS is a disorder of the immune system due to an inability to regulate lymphocyte homeostasis resulting in lymphadenopathy and hepatosplenomegaly. We describe a 17-year-old boy who was evaluated in the lipid clinic for history of undetectable or low HDL-C and low density lipoprotein cholesterol (LDL-C levels. Past medical history was significant for ALPS IA diagnosed at 10 years of age when he presented with bilateral cervical adenopathy. He was known to have a missense mutation in one allele of the FAS protein extracellular domain consistent with ALPS type 1A. HDL-C and LDL-C levels had been undetectable on multiple occasions, though lipids had not been measured prior to the diagnosis of ALPS. He had been receiving sirolimus for immunosuppression. The HDL-C and LDL-C levels correlated with disease activity and improved to normal levels during times when the activity of ALPS was controlled. This case highlights the importance of considering ALPS as a cause of low HDL-C and LDL-C levels in a child with evidence of lymphoproliferation.

  18. Characterization of antioxidant/anti-inflammatory properties and apoA-I-containing subpopulations of HDL from family subjects with monogenic low HDL disorders

    NARCIS (Netherlands)

    Daniil, Georgios; Phedonos, Alexia A. P.; Holleboom, Adriaan G.; Motazacker, Mohammad Mahdi; Argyri, Letta; Kuivenhoven, Jan Albert; Chroni, Angeliki

    2011-01-01

    Background: Genetic factors regulate both high-density lipoprotein (HDL) levels and functionality, thus affecting HDL antiatherogenic properties. We characterized the HDL antioxidant/anti-inflammatory properties and apoA-I-containing subpopulations in families with monogenic low HDL disorders.

  19. HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk.

    Directory of Open Access Journals (Sweden)

    Eliane Soler Parra

    Full Text Available Misclassification of patients as low cardiovascular risk (LCR remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL size has been appointed as a potential risk marker. Hence, we investigate whether HDL size improves the predictive value of HDL-cholesterol in the identification of carotid atherosclerotic burden in individuals stratified to be at LCR.284 individuals (40-75 years classified as LCR by the current US guidelines were selected in a three-step procedure from primary care centers of the cities of Campinas and Americana, SP, Brazil. Apolipoprotein B-containing lipoproteins were precipitated by polyethylene glycol and HDL size was measured by dynamic light scattering (DLS technique. Participants were classified in tertiles of HDL size (8.22 nm. Carotid intima-media thickness (cIMT 8.22 nm was independently associated with low cIMT in either unadjusted and adjusted models for age, gender and Homeostasis Model Assessment 2 index for insulin sensitivity, ethnicity and body mass index (Odds ratio 0.23; 95% confidence interval 0.07-0.74, p = 0.013.The mean HDL size estimated with DLS constitutes a better predictor for subclinical carotid atherosclerosis than the conventional measurements of plasma HDL-cholesterol in individuals classified as LCR.

  20. HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk.

    Science.gov (United States)

    Parra, Eliane Soler; Panzoldo, Natalia Baratella; Zago, Vanessa Helena de Souza; Scherrer, Daniel Zanetti; Alexandre, Fernanda; Bakkarat, Jamal; Nunes, Valeria Sutti; Nakandakare, Edna Regina; Quintão, Eder Carlos Rocha; Nadruz, Wilson; de Faria, Eliana Cotta; Sposito, Andrei C

    2014-01-01

    Misclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed as a potential risk marker. Hence, we investigate whether HDL size improves the predictive value of HDL-cholesterol in the identification of carotid atherosclerotic burden in individuals stratified to be at LCR. 284 individuals (40-75 years) classified as LCR by the current US guidelines were selected in a three-step procedure from primary care centers of the cities of Campinas and Americana, SP, Brazil. Apolipoprotein B-containing lipoproteins were precipitated by polyethylene glycol and HDL size was measured by dynamic light scattering (DLS) technique. Participants were classified in tertiles of HDL size (8.22 nm). Carotid intima-media thickness (cIMT) 8.22 nm was independently associated with low cIMT in either unadjusted and adjusted models for age, gender and Homeostasis Model Assessment 2 index for insulin sensitivity, ethnicity and body mass index (Odds ratio 0.23; 95% confidence interval 0.07-0.74, p = 0.013). The mean HDL size estimated with DLS constitutes a better predictor for subclinical carotid atherosclerosis than the conventional measurements of plasma HDL-cholesterol in individuals classified as LCR.

  1. The WWOX Gene Modulates HDL and Lipid Metabolism

    Science.gov (United States)

    Iatan, Iulia; Choi, Hong Y.; Ruel, Isabelle; Linga Reddy, M.V. Prasad; Kil, Hyunsuk; Lee, Jaeho; Abu Odeh, Mohammad; Salah, Zaidoun; Abu-Remaileh, Muhannad; Weissglas-Volkov, Daphna; Nikkola, Elina; Civelek, Mete; Awan, Zuhier; Croce, Carlo M.; Aqeilan, Rami I.; Pajukanta, Päivi; Aldaz, C. Marcelo; Genest, Jacques

    2014-01-01

    Background Low high-density lipoprotein-cholesterol (HDL-C) constitutes a major risk factor for atherosclerosis. Recent studies from our group reported a genetic association between the WW domain-containing oxidoreductase (WWOX) gene and HDL-C levels. Here, through next-generation resequencing, in vivo functional studies and gene microarray analyses, we investigated the role of WWOX in HDL and lipid metabolism. Methods and Results Using next-generation resequencing of the WWOX region, we first identified 8 variants significantly associated and perfectly segregating with the low-HDL trait in two multi-generational French Canadian dyslipidemic families. To understand in vivo functions of WWOX, we used liver-specific Wwoxhep−/− and total Wwox−/− mice models, where we found decreased ApoA-I and ABCA1 levels in hepatic tissues. Analyses of lipoprotein profiles in Wwox−/−, but not Wwox hep−/− littermates, also showed marked reductions in serum HDL-C concentrations, concordant with the low-HDL findings observed in families. We next obtained evidence of a gender-specific effect in female Wwoxhep−/− mice, where an increase in plasma triglycerides and altered lipid metabolic pathways by microarray analyses were observed. We further identified a significant reduction in ApoA-I and LPL, and upregulation in Fas, Angptl4 and Lipg, suggesting that the effects of Wwox involve multiple pathways, including cholesterol homeostasis, ApoA-I/ABCA1 pathway, and fatty acid biosynthesis/triglyceride metabolism. Conclusions Our data indicate that WWOX disruption alters HDL and lipoprotein metabolism through several mechanisms and may account for the low-HDL phenotype observed in families expressing the WWOX variants. These findings thus describe a novel gene involved in cellular lipid homeostasis, which effects may impact atherosclerotic disease development. PMID:24871327

  2. LCAT, HDL Cholesterol and Ischemic Cardiovascular Disease: A Mendelian Randomization Study of HDL Cholesterol in 54,500 Individuals

    DEFF Research Database (Denmark)

    Haase, Christiane L; Tybjærg-Hansen, Anne; Ali Qayyum, Abbas

    2012-01-01

    Background:Epidemiologically, high-density lipoprotein (HDL) cholesterol levels associate inversely with risk of ischemic cardiovascular disease. Whether this is a causal relation is unclear.Methods:We studied 10,281 participants in the Copenhagen City Heart Study (CCHS) and 50,523 participants...... in the Copenhagen General Population Study (CGPS), of which 991 and 1,693 participants, respectively, had developed myocardial infarction (MI) by August 2010. Participants in the CCHS were genotyped for all six variants identified by resequencing lecithin-cholesterol acyltransferase in 380 individuals. One variant......, S208T (rs4986970, allele frequency 4%), associated with HDL cholesterol levels in both the CCHS and the CGPS was used to study causality of HDL cholesterol using instrumental variable analysis.Results:Epidemiologically, in the CCHS, a 13% (0.21 mmol/liter) decrease in plasma HDL cholesterol levels...

  3. Development of a high density fuel based on uranium-molybdenum alloys with high compatibility in high temperatures; Desenvolvimento de um combustivel de alta densidade a base das ligas uranio-molibdenio com alta compatibilidade em altas temperaturas

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Fabio Branco Vaz de

    2008-07-01

    This work has as its objective the development of a high density and low enriched nuclear fuel based on the gamma-UMo alloys, for utilization where it is necessary satisfactory behavior in high temperatures, considering its utilization as dispersion. For its accomplishment, it was started from the analysis of the RERTR ('Reduced Enrichment for Research and Test Reactors') results and some theoretical works involving the fabrication of gamma-uranium metastable alloys. A ternary addition is proposed, supported by the properties of binary and ternary uranium alloys studied, having the objectives of the gamma stability enhancement and an ease to its powder fabrication. Alloys of uranium-molybdenum were prepared with 5 to 10% Mo addition, and 1 and 3% of ternary, over a gamma U7Mo binary base alloy. In all the steps of its preparation, the alloys were characterized with the traditional techniques, to the determination of its mechanical and structural properties. To provide a process for the alloys powder obtention, its behavior under hydrogen atmosphere were studied, in thermo analyser-thermo gravimeter equipment. Temperatures varied from the ambient up to 1000 deg C, and times from 15 minutes to 16 hours. The results validation were made in a semi-pilot scale, where 10 to 50 g of powders of some of the alloys studied were prepared, under static hydrogen atmosphere. Compatibility studies were conducted by the exposure of the alloys under oxygen and aluminum, to the verification of possible reactions by means of differential thermal analysis. The alloys were exposed to a constant heat up to 1000 deg C, and their performances were evaluated in terms of their reaction resistance. On the basis of the results, it was observed that ternary additions increases the temperatures of the reaction with aluminum and oxidation, in comparison with the gamma UMo binaries. A set of conditions to the hydration of the alloys were defined, more restrictive in terms of temperature, time and pre-treatment to stabilize the gamma structure. The addition of a bit low ternary excess and formation of an intergranular phase, the increase in stability, it was demonstrated that there is not a damage in the formation of their powders.(author)

  4. Desempenho produtivo de coelhos criados em diferentes densidades populacionais

    Directory of Open Access Journals (Sweden)

    Walter Motta Ferreira

    1999-02-01

    Full Text Available O objetivo deste experimento foi estudar os efeitos da densidade populacional sobre o desempenho produtivo de coelhos para corte na fase de recria. Foram utilizados 108 coelhos da raça Nova Zelândia Branco, de ambos os sexos, desmamados aos 28 dias e alojados aos 35 dias de idade por um período experimental de 6 semanas, em gaiolas de arame galvanizado, de dimensões 0,6 x 0,6 x 0,375 m, equipadas com comedouro automático e bebedouro tipo "nipple", instaladas em galpões semi-abertos. Os animais foram alimentados à vontade com ração peletizada comercial contendo 16% de proteína bruta (PB, 11,84% de fibra em detergente ácido (FDA, 17,49% de fibra em detergente neutro (FDN, 1,20% de cálcio (Ca, 0,60% de fósforo (P e 2500 kcal de energia digestível (ED/kg, ad libitum, em todo período experimental, e suplementados a partir dos 56 dias de idade com feno de capim Pangola (Digitaria decumbens, STENT contendo 4,04% PB; 37,31% FDA; 52,04%FDN; 0,61% Ca; 0,10% P; e 1180 kcal ED/kg, oferecido na quantidade de 50 gramas por animal/dia. As densidades populacionais testadas foram de 1200, 900, 720 e 600 cm²/animal, equivalentes às lotações de 3, 4, 5 e 6 animais por gaiola, respectivamente. O aumento da densidade populacional acarretou diminuição significativa do ganho de peso diário e do consumo diário de ração por animal alojado, sem influir na conversão alimentar e no rendimento de carcaça. Não houve efeito de sexo nas variáveis estudadas. A mortalidade ocorrida no período experimental não apresentou associação com a densidade populacional.

  5. Hypertriglyceridaemia, postprandial lipaemia and non-HDL cholesterol.

    Science.gov (United States)

    Stefanutti, Claudia; Labbadia, Giancarlo; Athyros, Vasilios G

    2014-01-01

    Maintaining total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels within healthy limits decreases the risk of atherosclerotic vascular disease (AVD) and cardiovascular (CV) events. The predictive value of elevated TG levels for coronary artery disease (CAD) seen in univariate analysis tends to disappear on multivariate analyses, especially when correction is made for HDL-C. The relationship between TG and HDL-C is complex and not fully understood. Hydrolysis of TG by lipoprotein lipase converts HDL subclass 3 to a larger lipoprotein enriched in both phospholipid and TG. This process occurs in postprandial lipaemia (PPL). An additional factor for the complex relationship between TGs and CV risk is that the lipoproteins which transport plasma TG (chylomicrons, very low density lipoproteins and their remnants) are heterogeneous particles. Therefore, they may differ in their level of atherogenicity. PPL is a physiological process during which plasma lipoproteins and their subclasses undergo variations in concentration and composition following consumption of food, particularly fatty food. "Postprandial hyperlipidaemia" is the quantitative/qualitative alteration of this normal process. These lipoprotein alterations could play a role in the development of CV disease (CVD). However, lipid levels used to evaluate CV risk are usually measured in the fasting state. This review focuses on TG, PPL, postprandial hyperlipidaemia and non-HDL-C, their relationships and potential predictive role in atherogenesis and CVD.

  6. TransAlta retires Wabamun power plant

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2010-06-15

    The Wabamun power plant has been shut down after 54 years of service in Alberta. The phased shut-down of the 4-unit plant was announced in 2002, and the last operating unit ended commercial operation on March 11, 2010. As the owners of the facility, TransAlta will now complete the remediation and reclamation work required by the government of Alberta. The 537 MW generating facility has helped to fuel Alberta's economic growth over the last 54 years. TransAlta plans to modernize its coal fleet with the Keephill 3 plant and add more renewable energy sources in the future. The Keephill 3 is a joint venture between TransAlta and Capital Power Corporation. The 450 MW coal-fired power plant is equipped with super-critical technology. The new plant will also be the test site for Project Pioneer, a carbon capture and storage (CCS) initiative.

  7. Doble excepcionalidad: Dislexia y alta capacidad intelectual

    OpenAIRE

    San Millán González, Paula

    2015-01-01

    El presente trabajo versa sobre el diseño de una página web titulada "Un mundo al revés", cuyo título pretende hacer un "guiño" al contenido que en ella se trata, es decir, la doble excepcionalidad: Dislexia y Alta Capacidad Intelectual. La doble excepcionalidad es una realidad escolar; no obstante, se trata de un tema de actualidad por lo que considero necesario realizar previamente un marco teórico para conocer las bases de la dislexia, de la alta capacidad intelectual y de la doble excepci...

  8. Antioxidative activity of high-density lipoprotein (HDL: Mechanistic insights into potential clinical benefit

    Directory of Open Access Journals (Sweden)

    Fernando Brites

    2017-12-01

    Antioxidative function of HDL can be impaired in several metabolic and inflammatory diseases. Structural and compositional anomalies in the HDL proteome and lipidome underlie such functional deficiency. Concomitant normalization of the metabolism, circulating levels, composition and biological activities of HDL particles, primarily those of small, dense HDL3, can constitute future therapeutic target.

  9. Riqueza e densidade de aves que nidificam em cavidades em plantações abandonadas de eucalipto

    Directory of Open Access Journals (Sweden)

    Hugo de Siqueira Pereira

    2015-05-01

    Full Text Available Monoculturas de árvores, como as de espécies de eucalipto, têm substituído florestas naturais, impactando a fauna pela perda de habitat e recursos. Diversas espécies de aves necessitam de ocos em árvores para nidificar. A falta de recursos como cavidades formadas pela degradação da árvore ou locais apropriados para serem criadas cavidades leva a diminuição na abundância das populações destas espécies. Este trabalho tem o objetivo de comparar a riqueza e a densidade de aves que nidificam em ocos em áreas de plantação de eucalipto abandonadas com áreas de vegetação nativa em duas unidades de conservação em Minas Gerais. Em cada tipo de vegetação de cada reserva foram estabelecidos 25 pontos, nas quais foi utilizado o método de contagem por remoção para o levantamento das espécies de aves. A riqueza de espécies de aves de cada área foi estimada por Jackniffe e a densidade foi estimada através do método de máxima verossimilhança; modelos candidatos que poderiam influenciar a abundância das aves foram avaliados utilizando-se o Critério de Informação Akaike (AIC. Os resultados mostraram que a riqueza de espécies foi maior nas áreas de florestas nativas e que a densidade foi significantemente mais alta nas áreas de florestas nativas, e que o tipo de vegetação e a hora do dia influenciam na abundância e detecção das aves. Esses resultados indicam que as plantações de eucaliptos influenciam negativamente a comunidade de aves que nidificam em ocos, provavelmente por causa da falta de cavidades ou de sub-bosque. Plantações de eucaliptos normalmente não substituem as florestas nativas e seu uso deve ser controlado em áreas de conservação.

  10. MOLECULAR DYNAMICS SIMULATION AND EXPERIMENTAL STUDIES OF GOLD NANOPARTICLE TEMPLATED HDL-LIKE NANOPARTICLES FOR CHOLESTEROL (POSTPRINT)

    Science.gov (United States)

    2016-12-21

    pharmaceutical industry have tried to develop HDL mimics for various therapeutic purposes.14,15 Studies have demonstrated that functional mimics of HDL...Ester Formation on HDL AuNP. The HDL AuNP and bilayer NP (HDL AuNP without apoA-I) were synthesized as previously described.17 After synthesis , HDL

  11. HIFSuite: Tools for HDL Code Conversion and Manipulation

    Directory of Open Access Journals (Sweden)

    Bombieri Nicola

    2010-01-01

    Full Text Available Abstract HIFSuite ia a set of tools and application programming interfaces (APIs that provide support for modeling and verification of HW/SW systems. The core of HIFSuite is the HDL Intermediate Format (HIF language upon which a set of front-end and back-end tools have been developed to allow the conversion of HDL code into HIF code and vice versa. HIFSuite allows designers to manipulate and integrate heterogeneous components implemented by using different hardware description languages (HDLs. Moreover, HIFSuite includes tools, which rely on HIF APIs, for manipulating HIF descriptions in order to support code abstraction/refinement and postrefinement verification.

  12. Alta Capital investeerib miljardeid kroone / Raigo Neudorf

    Index Scriptorium Estoniae

    Neudorf, Raigo

    2006-01-01

    Investeerimisfirma Alta Capital nõukogu esimees Indrek Rahumaa annab ülevaate sellest, kuidas ettevõte on lühikese ajaga suutnud omandada osaluse mitmetes ettevõtetes ning suunanud neisse investeeringuid 150 miljoni euro väärtuses. Vt. samas: Osalused; Omanikud

  13. Espectroscopía UV de Alta Resolución para las atmósferas de las Supergigantes-A

    OpenAIRE

    Verdugo, Eva; Gómez de Castro, Ana Inés; Talavera, Antonio

    2007-01-01

    Las supergigantes de tipo-A son las estrellas intrínsecamente más brillantes en el visible y, por lo tanto, uno de los mejores indicadores de distancias extragalácticas en potencia. Estas estrellas presentan procesos físicos muy complejos en sus atmósferas con un campo de radiación muy energético y de alta densidad de momento, en combinación con una atmósfera extendida y tenue y un viento estelar. Uno de los mejores trazadores de estas envolturas extensas son las l ' ineas U...

  14. Efectos fisiológicos de la termorregulación en trabajadores expuestos a altas temperaturas en una Siderúrgica en Colombia.

    OpenAIRE

    Villarraga Neuta, Danna Karenina

    2015-01-01

    La exposición a altas temperaturas en ambientes laborales conlleva a cambios fisiológicos que se manifiestan como mecanismos de compensación a la alteración del equilibrio homeostático corporal. El propósito del presente estudio fue determinar los cambios y el comportamiento de variables fisiológicas a través de frecuencia cardiaca, densidad urinaria, temperatura corporal y tasa de sudoración, en dos escenarios con condiciones térmicas ambientales diferentes definidas por la exposición (grup...

  15. Compactação do solo na cultura do arroz de terras altas Soil compaction on upland rice

    Directory of Open Access Journals (Sweden)

    Cleber Morais Guimarães

    2001-04-01

    Full Text Available A presente pesquisa teve o objetivo de avaliar o efeito da compactação do solo sobre duas cultivares de arroz de terras altas. O experimento foi realizado em casa de vegetação, utilizando um Latossolo Vermelho-Escuro, de textura franca, com densidades do solo de 1,2, 1,3, 1,4, 1,5, 1,6 e 1,7 g cm-3. Estas densidades foram produzidas artificialmente, na camada de 0-20 cm de profundidade, em colunas de solo com 24,4 cm de diâmetro. O solo foi mantido em potencial da água superior a 0,035 MPa. O comportamento do arroz foi avaliado aos 40 dias após a emergência, por meio de parâmetros da parte aérea e radicular da planta. O crescimento da parte aérea do arroz de terras altas diminui com o aumento da densidade do solo a partir de 1,2 g cm³; as raízes na camada compactada de 0-20 cm de profundidade apresentam engrossamento, em razão do aumento da densidade do solo; e a compactação superficial do solo diminui a quantidade de raízes presentes nesta camada e na camada inferior não-compactada de 20-40 cm de profundidade.A greenhouse experiment was conducted with the objective to evaluate the effects of soil compaction on two upland rice genotypes grown in a Dark Red Latosol with loam texture, having densities of 1.2, 1.3, 1.4, 1.5, 1.6 and 1.7 g cm-3. Soil density values were created artificially at 0-20 cm soil depth using plastic tubes of 24.4 cm of diameter. Soil water potential was maintained at 0.035 MPa. Treatment effects were evaluated 40 days after seedling emergence using the shoot dry weight and the root system as parameters. Results obtained for both cultivars indicated that shoot growth was decreased by increasing soil density beyond 1.2 g cm-3 and also that root thickness increased with increasing soil density. Additionally, superficial soil compaction reduced the amount of roots present at 0-20 cm soil depth as well as at 20-40 cm.

  16. marital status and occupation versus serum total cholesterol and hdl

    African Journals Online (AJOL)

    DR. AMIN

    Keywords: Occupation, Cholesterol, Kano, Serum Lipid. INTRODUCTION. Differences in serum HDL – CH and low density lipoprotein cholesterol (LDL – CH) levels between communities have been employed in explaining the postulated relationship that exist between serum lipoprotein levels and the incidence of coronary ...

  17. Plasma HDL cholesterol and risk of myocardial infarction

    DEFF Research Database (Denmark)

    Voight, Benjamin F; Peloso, Gina M; Orho-Melander, Marju

    2012-01-01

    High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendel...

  18. HDL-cholesterol reductions associated with adult growth hormone replacement.

    Science.gov (United States)

    Leese, G P; Wallymahmed, M; VanHeyningen, C; Tames, F; Wieringa, G; MacFarlane, I A

    1998-11-01

    To study the effects of human growth hormone (hGH) replacement on serum lipids and lipoprotein (a) (Lp(a)) concentrations. A randomized double blind placebo controlled trial for 6 months followed by an open trial where all patients were treated with hGH for a further 6 months. Treatment was with recombinant hGH given in a dose of 0.125U/kg/wk increasing to 0.25U/Kg/wk. Thirty two patients with growth hormone deficiency were recruited, but two withdrew because of side effects. Of the thirty patients (age 35.1 +/- 11.8 year; mean +/- SD) completing the study 13 of were assigned to the placebo group for six months and 17 to active treatment from the start. Fasting serum samples were analysed for total cholesterol, High density lipoprotein (HDL)-cholesterol, HDL-subfractions, triglycerides, lipoprotein (a) (Lp(a)) and IGF-1. LDL-cholesterol was calculated using the Friedewald formula. Compared to placebo, 6 months treatment with hGH therapy resulted in increased IGF-1 (37.6 +/- 4.1 vs. 14.0 +/- 2.2 nmol/l, P hGH was associated with a decrease in HDL-cholesterol concentration from baseline to 6 months (0.97 +/- 0.08 to 0.76 +/- 0.10 mmol/l P hGH can reduce serum HDL-cholesterol concentrations. Further investigation of this is required.

  19. Seleção de progênies S0:1 de milho em diferentes densidades de semeadura Selection of S0:1 maize progenies under different plant densities

    Directory of Open Access Journals (Sweden)

    André Gustavo Steola

    2006-01-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito da densidade de semeadura sobre o processo de seleção de progênies endogâmicas S0:1 de milho. Utilizaram-se 98 progênies S0:1 derivadas do híbrido simples GNZ 2004, avaliadas em duas densidades de semeadura (50 mil e 75 mil plantas ha-1 . Em cada densidade foram avaliadas as 98 progênies S0:1, juntamente com o híbrido GNZ 2004 e sua geração F2. O delineamento utilizado em ambas as densidades foi o látice simples 10 x 10, com duas repetições. Os experimentos foram desenvolvidos em área experimental do Departamento de Agricultura da Universidade Federal de Lavras, em Lavras (MG. As características avaliadas foram produtividade de espigas despalhadas e prolificidade. Pelos resultados obtidos constatou-se variabilidade genética entre as progênies S0:1 nas duas densidades avaliadas, havendo a possibilidade de seleção de progênies com maior potencial de produção de espigas despalhadas. A não-significância da interação entre as progênies S0:1 e as densidades de semeadura associadas às altas correlações genéticas obtidas evidenciam que a seleção poderá ser realizada em qualquer uma das duas densidades, sem comprometer o processo seletivo.The present work aimed to evaluate the effect of planting density on the selection of inbred progenies. GNZ 2004 single hybrid, its F2 generation and ninety-eight S0:1 progenies were evaluated in two plant densities, 50 thousand and 75 thousand plants ha-1in a simple 10x10 lattice design. The experiment was performed in the experimental area of the Agriculture Department of the Universidade Federal de Lavras, in Lavras, Minas Gerais State, Brazil. Yield of husked ear and prolificy were evaluated. Results showed genetic variation among the S0:1 progenies in the two densities, allowing the selection of progenies with higher potential for production of husked ear corn. Interaction of the progenies x densities was not significant that

  20. Relation of Oxidative Stress and Impaired Fibrinolysis with HDL Biogenesis in Indonesian Men with Metabolic Syndrome

    Directory of Open Access Journals (Sweden)

    Ida Paulina Sormin

    2010-04-01

    Full Text Available BACKGROUND: Biogenesis of HDL involves factors that regulate the synthesis, intravascular remodeling, and catabolism of HDL. Disturbance of these factors can lead to low concentration of HDL-C. Metabolic syndrome (MetS is characterized by low concentration of high-density lipoprotein cholesterol (HDL-C. In MetS occur several pathological conditions including oxidative stress and impaired fibrinolysis, which contribute to the risk of atherosclerosis process. The correlation between oxidative stress and impaired fibrinolysis with HDL biogenesis dysfunction and its correlation with low concentration of HDL-C has not been well understood and therefore needs to be further investigated. METHODS: This study was an observational study with crosssectional design, involving 163 adult men, aged 25-60 years with metabolic syndrome. Concentration of apoA-1, prebeta-1 HDL, CETP, F2-isoprostan, PAI-1, and HDL-C were measured. The apo A1/HDL ratio indicated HDL maturation, whereas the CETP/HDL-C and CETP/TG ratios indicated HDL catabolism. RESULTS: The study showed that there were a positive correlation between PAI-1 with apoA1/HDL-C ratios (r=0.226, p=0.005 and a negative correlation with the CETP/TG ratios (r=-0.215, p=0.007, whereas F2-isoprostan did not have correlation with HDL biogenesis factors. CONCLUSIONS: We concluded that there was correlation between impaired fibrinolysis with decreased HDL maturation and there was increased HDL catabolism leading to low HDL-C concentration in men with metabolic syndrome. KEYWORDS: F2-isoprostan, PAI-1, apoA-1, prebeta-1 HDL, CETP, metabolic syndrome.

  1. Los profesores de alumnos con altas habilidades

    Directory of Open Access Journals (Sweden)

    Cándido GENOVARD

    2010-01-01

    Full Text Available En este trabajo analizamos las características de los profesores expertos para alumnos de altas habilidades. Se analizan los antecedentes del tema y el proceso instruccional para atender la diversidad de estos alumnos. Se destaca el valor de las interacciones entre profesor¿ alumnos y los estilos de enseñar y aprender. Asimismo, recogemos pautas de acción y recursos instruccionales a utilizar en el aula para la enseñanza de estos alumnos. No hay un profesor ideal para los alumnos con altas habilidades, pero los docentes deben conocer qué son y cómo funcionan los procesos de enseñanza¿aprendizaje y las variables psicológicas, de contenidos y contextuales implicadas en éstos.

  2. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

    DEFF Research Database (Denmark)

    Zanoni, Paolo; Khetarpal, Sumeet A; Larach, Daniel B

    2016-01-01

    Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL......-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains unclear. Through targeted sequencing of coding regions of lipid-modifying genes in 328 individuals with extremely high plasma HDL-C levels, we identified a homozygote for a loss-of-function...

  3. Diffusione molecolare neLl' alta atmosfera

    Directory of Open Access Journals (Sweden)

    C. ARDUINI

    1963-06-01

    Full Text Available Le perturbazioni indotte nell'alta atmosfera dall'emissione,
    a mezzo di razzi sonda, di nubi di vapori estranei sono un utile
    mezzo per lo studio simultaneo di alcune caratteristiche fisiche e dinamiche
    degli alti strati.
    La presente relazione illustra in breve i principi di alcune tecniche
    per la misura del coefficiente di diffusione binaria tra l'aria e il vapore
    della nube artificiale.

  4. TransAlta 2003 annual report

    International Nuclear Information System (INIS)

    2004-01-01

    This annual report presents financial information from TransAlta Corp., along with a review of its operations throughout 2003 and a summary of the how the electric utility has performed in terms of power generation, independent power producers, transmission and energy marketing. TransAlta is one of the largest non-regulated power generation and wholesale marketing companies in Canada. It's assets include coal-fired, gas-fired, hydro and renewable generation facilities in Canada, the United States, Mexico and Australia. Reported earnings in 2003 were $1.26 per share compared to $1.17 in 2002. The strong first quarter was followed by harsh market conditions, low water levels which affected hydro production, and pricing restrictions in Ontario that reduced contribution from the Sarnia plant. This report outlines the utility's progress in increasing revenue and producing more power. In 2003, unplanned outages were reduced by 7 per cent and injury frequency rate was reduced by 27 per cent. The installation of 114 wind turbines in Fort Macleod, Alberta, increased TransAlta's renewable energy capacity to 3.7 per cent in 2003. The wind farm produces 75 MW of electricity, enough to power more than 32,500 homes annually. This report summarized the company's energy resource activities and presented an operations review as well as consolidated financial statements and common share information. This included the utility's assets, liabilities, revenues, expenses and cash flows. Revenue and expenditure statements were summarized by source. refs., tabs., figs

  5. High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study

    NARCIS (Netherlands)

    Arts, E.; Fransen, J.; Lemmers, H.; Stalenhoef, A.F.; Claessens-Joosten, L.; Riel, P. van; Popa, C.

    2012-01-01

    INTRODUCTION: Higher levels of high density lipoprotein (HDL) subfractions HDL3-chol and particularly HDL2-chol protect against cardiovascular disease (CVD), but inflammation reduces the HDL level and may impair its anti-atherogenic effect. Changed HDL composition through the impact of inflammation

  6. Prevalence of low HDL-cholesterol in patients with cardiovascular risk factors: The ECHOS (Etude du Cholesterol HDL en Observationnel) French Survey.

    Science.gov (United States)

    Farnier, M; Garnier, P; Yau, C; Dejager, S; Verpilleux, M P

    2006-10-01

    A low concentration of high-density lipoprotein-cholesterol (HDL-C) is an independent risk factor for cardiovascular heart disease (CHD), but little is known about the distribution of HDL-C in France. This study evaluated the prevalence of low HDL-C among a large French population (5232 patients) with other cardiovascular risk factors. Depending on the guidelines used, the prevalence of low HDL-C varied from 8.7% (cutoff value of 35 mg/dl) to 26.9% (National Cholesterol Education Program metabolic syndrome cutoff values). The prevalence of low HDL-C gradually increased with the number of associated risk factors. We identified three independent risk predictors for low HDL-C: hypertriglyceridaemia (HTG), abdominal obesity and gender. Overall, the frequency of HDL-C assessment was very high (>85%) and it was highest in patients with hypercholesterolaemia or a history of CHD. Risk factors more frequently associated with low HDL-C (i.e. HTG, abdominal obesity and type 2 diabetes) were not associated with a more frequent assessment of HDL-C. Our findings indicate that in France, the prevalence of low HDL-C remains relatively high, particularly for patients with obesity and HTG.

  7. Cholesterol Efflux Capacity and Subclasses of HDL Particles in Healthy Women Transitioning Through Menopause.

    Science.gov (United States)

    El Khoudary, Samar R; Hutchins, Patrick M; Matthews, Karen A; Brooks, Maria M; Orchard, Trevor J; Ronsein, Graziella E; Heinecke, Jay W

    2016-09-01

    Growing evidence challenges the concept that high-density lipoprotein-cholesterol (HDL-C) is cardioprotective after menopause. HDL particle concentration (HDL-P) and cholesterol efflux capacity (CEC) might be better predictors of cardiovascular risk. Quantify alterations in HDL-P and CEC during menopause, correlating those changes with alterations in estradiol (E2) and FSH. Longitudinal study of HDL metrics before and after menopause as indexed by the final menstrual period (FMP). Forty-six women, mean baseline age 47.1 years, 33% black, 67% white. HDL-P concentration (HDL-PIMA) by calibrated ion mobility analysis (IMA); macrophage CEC with cAMP-stimulated macrophages; ATP-binding cassette transporter A1 (ABCA1)-specific CEC with BHK cells expressing human ABCA1. After a median of 2.1 years since FMP, both HDL-C (P = .03) and HDL-PIMA (P = .01) increased, with a selective increase in large HDL-PIMA (P = .01), whereas sizes of medium and small HDL-PIMA were decreased (P changes were independent of race, body mass index, and time difference. Macrophage CEC and ABCA1-specific CEC increased after FMP (both P menopause (P = .04 and .009, respectively). Large HDL-PIMA and CEC increased significantly in the early phase of the menopausal transition. Whether patterns of these alterations differ in late postmenopause is unknown. Further exploration is needed to assess that and to determine whether the reported changes in HDL metrics associate with increased cardiovascular risk after menopause.

  8. Mechanism of transfer of LDL-derived free cholesterol to HDL subfractions in human plasma

    International Nuclear Information System (INIS)

    Miida, T.; Fielding, C.J.; Fielding, P.E.

    1990-01-01

    The transfer of [ 3 H]cholesterol in low-density lipoprotein (LDL) to different high-density lipoprotein (HDL) species in native human plasma was determined by using nondenaturing two-dimensional electrophoresis. Transfer from LDL had a t 1/2 at 37 degree C of 51 ± 8 min and an activation energy of 18.0 kCal mol -1 . There was unexpected specificity among HDL species as acceptors of LDL-derived labeled cholesterol. The largest fraction of the major α-migrating class (HDL 2b ) was the major initial acceptor of LDL-derived cholesterol. Kinetic analysis indicated a rapid secondary transfer from HDL 2b to smaller αHDL (particularly HDL 3 ) driven enzymatically by the lecithin-cholesterol acyltransferase reaction. Rates of transfer among αHDL were most rapid from the largest αHDL fraction (HDL 2b ), suggesting possible protein-mediated facilitation. Simultaneous measurements of the transport of LDL-derived and cell-derived isotopic cholesterol indicated that the former preferably utilized the αHDL pathyway, with little label in pre-βHDL. The same experiments confirmed earlier data that cell-derived cholesterol is preferentially channeled through pre-βHDL. The authors suggest that the functional heterogeneity of HDL demonstrated here includes the ability to independently process cell- and LDL-derived free cholesterol

  9. Densidade de estocagem e salinidade da água na larvicultura do pacamã

    OpenAIRE

    Luz,Ronald Kennedy; Santos,José Cláudio Epaminondas dos

    2008-01-01

    O objetivo deste trabalho foi avaliar o efeito da densidade de estocagem e da salinidade da água, na larvicultura do pacamã Lophiosilurus alexandri, alimentado com náuplios de Artemia sp. Foram utilizadas três densidades de estocagem: 20, 40 e 60 larvas L-1 (D20, D40 e D60, respectivamente). Para cada densidade testaram-se três índices de salinidade da água: água doce (S0), 2‰ (S2) e 4‰ (S4), em delineamento experimental inteiramente ao acaso, em esquema fatorial 3x3, com três repetições. For...

  10. Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk

    DEFF Research Database (Denmark)

    Morton, Allyson M; Koch, Manja; Mendivil, Carlos O

    2018-01-01

    BACKGROUND: Subspecies of HDL contain apolipoprotein E (apoE) and/or apoCIII. Both proteins have properties that could affect HDL metabolism. The relation between HDL metabolism and risk of coronary heart disease (CHD) is not well understood. METHODS: Eighteen participants were given a bolus...... infusion of [D3]L-leucine to label endogenous proteins on HDL. HDL was separated into subspecies containing apoE and/or apoCIII and then into 4 sizes. Metabolic rates for apoA-I in HDL subspecies and sizes were determined by interactive modeling. The concentrations of apoE in HDL that contain or lack apo......CIII were measured in a prospective study in Denmark including 1,949 incident CHD cases during 9 years. RESULTS: HDL containing apoE but not apoCIII is disproportionately secreted into the circulation, actively expands while circulating, and is quickly cleared. These are key metabolic steps in reverse...

  11. Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population

    DEFF Research Database (Denmark)

    Frikke-Schmidt, Ruth; Nordestgaard, Børge G; Jensen, Gorm B

    2004-01-01

    Homozygosity for mutations in ABC transporter A1 (ABCA1) causes Tangier disease, a rare HDL-deficiency syndrome. Whether heterozygosity for genetic variation in ABCA1 also contributes to HDL cholesterol (HDL-C) levels in the general population is presently unclear. We determined whether mutations...

  12. HDL-LDL Ratio: A Significant Predisposition to the Onset of ...

    African Journals Online (AJOL)

    The significance of high-density lipoprotein/low density lipoprotein (HDL-LDL) ratio as a predisposing factor to the onset of atherogenesis has been studied. Standard enzymatic method using Cholesterol kit to extract cholesterol was used. HDL was analysed using standard HDL Kit and LDL concentration was derived by a ...

  13. Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans

    NARCIS (Netherlands)

    Brunham, Liam R.; Tietjen, Ian; Bochem, Andrea E.; Singaraja, Roshni R.; Franchini, Patrick L.; Radomski, Chris; Mattice, Maryanne; Legendre, Annick; Hovingh, G. Kees; Kastelein, John J. P.; Hayden, Michael R.

    2011-01-01

    The scavenger receptor class B, member 1 (SR-BI), is a key cellular receptor for high-density lipoprotein (HDL) in mice, but its relevance to human physiology has not been well established. Recently a family was reported with a mutation in the gene encoding SR-BI and high HDL cholesterol (HDL-C).

  14. PXR agonism decreases plasma HDL levels in ApoE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    Haan, W. de; Vries-van der Weij, J. de; Mol, I.M.; Hoekstra, M.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Princen, H.M.G.; Rensen, P.C.N.

    2009-01-01

    Pregnane X receptor (PXR) agonism has been shown to affect multiple steps in both the synthesis and catabolism of HDL, but its integrated effect on HDL metabolism in vivo remains unclear. The aim of this study was to evaluate the net effect of PXR agonism on HDL metabolism in ApoE*3-Leiden (E3L) and

  15. Chapter 2 Western dominance Piedra Alta terrane

    International Nuclear Information System (INIS)

    2005-01-01

    Piedra Alta Stone includes: geo chemical and geochronology of the granitic complex is located in the SW portion of the crystalline basement of Uruguay. It consists of four thin metamorphic belts separated by a granitic complex - gneissic - migmatítico (CGG) and associated with an important granite, granodiorite, basic or ultrabasic magmatic. Belts north to south are called Arroyo Grande Andresito by renowned Bossi et al. (2000); San Jose (Preciozzi et al., 1991), San Juan (Preciozzi et al, 2005) and Montevideo (Bossi et al., 1993) Pando by renowned Bossi et al. (2000). They are composed of volcano-sedimentary units of different degrees of metamorphism and a set of associated intrusions

  16. Fatores que influenciam o padrão radiológico de densidade das mamas Factors influencing the density radiological pattern of the breast

    Directory of Open Access Journals (Sweden)

    Rosa Nara Machado Figueira

    2003-10-01

    Full Text Available O padrão de densidade mamográfica deve ser referido, com a finalidade de atentar o clínico para possíveis dificuldades no diagnóstico da afecção mamária, pois são conhecidas a menor sensibilidade e especificidade da mamografia em mamas densas. OBJETIVO: Correlacionar os diferentes padrões de densidade mamográfica com possíveis fatores que possam modificá-los, tais como idade, paridade e índice de massa corporal. MATERIAIS E MÉTODOS: Foram avaliados 849 mulheres e seus respectivos exames mamográficos, para identificação do padrão de densidade mamária, idade, paridade e índice de massa corporal. Realizou-se o teste do qui-quadrado, coeficiente de contingência e regressão logística. RESULTADOS: A maioria das mulheres situou-se na faixa etária dos 36 aos 55 anos. Houve predomínio dos padrões de baixa densidade (73,7% sobre os de alta densidade (26,3%. Multiparidade foi encontrada em 69,8% da amostra, houve 16,5% de nulíparas e 13,7% com um filho. O índice de massa corporal foi normal em 53,3% das mulheres, 26,9% apresentaram sobrepeso, 9,5% eram obesas e 11,3% estavam abaixo do peso ideal. CONCLUSÃO: Os padrões densos foram influenciados pela idade jovem, nuliparidade e menor índice de massa corporal. Os padrões de baixa densidade aumentaram com a idade, o número de filhos e o índice de massa corporal.The density pattern of the breasts should be reported to the clinician in view of the possible difficulties in the diagnosis of mammary disease due to reduced sensitiveness and specificity in patients with dense breasts. OBJECTIVE: The aim of this paper was to correlate the different mammography density patterns with possibly modifying factors such as age, parity and body mass index. MATERIALS AND METHODS: Eight hundred and forty-nine women and their respective mammography examinations were evaluated in order to identify the density pattern of the breasts, age, parity and body mass index. Chi-square test, contingency

  17. Regional variations in HDL metabolism in human fat cells: effect of cell size

    International Nuclear Information System (INIS)

    Despres, J.; Fong, B.S.; Julien, P.; Jimenez, J.; Angel, A.

    1987-01-01

    Abdominal obesity is related to reduced plasma high-density lipoprotein (HDL) cholesterol, and both are associated with cardiovascular disease risk. The authors have observed that plasma membranes from abdominal subcutaneous adipocytes have a greater HDL binding capacity than omental fat cell plasma membranes. The present study examined whether these binding characteristics could be due to differences in fat cell size or cholesterol concentration between the two adipose depots. Abdominal subcutaneous and deep omental fat were obtained from massively obese patients at surgery. Subcutaneous abdominal fat cells were significantly larger and their cellular cholesterol content greater than omental adipocytes. The uptake of HDL by collagenase-isolated fat cells was studied by incubating the cells for 2 h at 37 0 C with 10 μg/ml 125 I-HDL 2 or 125 I-HDL 3 . In both depots, the cellular uptake of 125 I-HDL 2 and 125 I-HDL 3 was specifically inhibited by addition of 25-fold excess unlabeled HDL and a close correlation was observed between the cellular uptake of 125 I-HDL 2 and 125 I-HDL 3 . In obese patients, the uptake of 125 I-HDL was higher in subcutaneous cells than in omental cells. The cellular 125 I-HDL uptake was significantly correlated with adipocyte size and fat cell cholesterol content but not with adipocyte cholesterol concentration. These results suggest that the higher HDL uptake observed in subcutaneous cells compared with omental cells in obesity is the result of differences in adipocyte size rather than differences in the cholesterol concentration (cholesterol-to-triglyceride ratio). The increased interaction of HDL with hypertrophied abdominal adipocytes may play an important role in determining the lipid composition of HDL in obesity

  18. procesos de alta temperatura en pymes

    Directory of Open Access Journals (Sweden)

    ANDRÉS AMELL

    2007-01-01

    Full Text Available La búsqueda de tecnologías de calentamiento que reduzcan el consumo de combustible, disminuyan las emisiones contaminantes y mejoren la productividad de los procesos y calidad de los productos en procesos de alta temperatura, ha motivado la investigación y desarrollo tecnológico de sistemas térmicos. En este contexto el artículo presenta los resultados del proyecto “Desarrollo y Evaluación de un Sistema de Combustión Autoregenerativo y Radiante para Procesos de Alta Temperatura en Pequeñas y Medianas Empresas PyMES”, presentando la configuración, funcionamiento, caracterización, parámetros de operación y comportamiento de un prototipo desarrollado que opera con 28 kW de potencia térmica con base al poder calorífico inferior, factores de aireación de 1.05 y 1.20 y temperaturas de precalentamiento de aire hasta de 700ºC.

  19. Rheological characterization of LDPE{sub Al} (low density polyethylene and aluminum) e HDPE (high density polyethylene); Caracterizacao das propriedades reologicas da mistura LDPE{sub Al} (polietileno de baixa densidade e aluminio) e HDPE (polietileno de alta densidade)

    Energy Technology Data Exchange (ETDEWEB)

    Santa Marinha, Ana Beatriz Abreu; Pacheco, Elen Beatriz Acordi Vasques; Monteiro, Elisabeth Ermel da Costa [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Macromoleculas

    2008-07-01

    The long life packaging contains paper, polyethylene and aluminum for packaging of food. A few part of total amount produced is recycled and another is discharged in landfills in Brazil. The low density polyethylene and aluminum (LDPE{sub Al}) was obtained from recycling this packaging. The rheological properties of the blends were intermediate to ones of the pure polymers. In a general way, the rheological properties were not modified by the aluminum presence. (author)

  20. HDL code analysis for ASICs in mobile systems

    OpenAIRE

    Wickberg, Fredrik

    2007-01-01

    The complex work of designing new ASICs today and the increasing costs of time to market (TTM) delays are putting high responsibility on the research and development teams to make fault free designs. The main purpose of implementing a static rule checking tool in the design flow today is to find errors and bugs in the hardware definition language (HDL) code as fast and soon as possible. The sooner you find a bug in the design, the shorter the turnaround time becomes, and thereby both time and...

  1. HDL proteome in hemodialysis patients: a quantitative nanoflow liquid chromatography-tandem mass spectrometry approach.

    Directory of Open Access Journals (Sweden)

    Alain Mangé

    Full Text Available Aside from a decrease in the high-density lipoprotein (HDL cholesterol levels, qualitative abnormalities of HDL can contribute to an increase in cardiovascular (CV risk in end-stage renal disease (ESRD patients undergoing chronic hemodialysis (HD. Dysfunctional HDL leads to an alteration of reverse cholesterol transport and the antioxidant and anti-inflammatory properties of HDL. In this study, a quantitative proteomics approach, based on iTRAQ labeling and nanoflow liquid chromatography mass spectrometry analysis, was used to generate detailed data on HDL-associated proteins. The HDL composition was compared between seven chronic HD patients and a pool of seven healthy controls. To confirm the proteomics results, specific biochemical assays were then performed in triplicate in the 14 samples as well as 46 sex-matched independent chronic HD patients and healthy volunteers. Of the 122 proteins identified in the HDL fraction, 40 were differentially expressed between the healthy volunteers and the HD patients. These proteins are involved in many HDL functions, including lipid metabolism, the acute inflammatory response, complement activation, the regulation of lipoprotein oxidation, and metal cation homeostasis. Among the identified proteins, apolipoprotein C-II and apolipoprotein C-III were significantly increased in the HDL fraction of HD patients whereas serotransferrin was decreased. In this study, we identified new markers of potential relevance to the pathways linked to HDL dysfunction in HD. Proteomic analysis of the HDL fraction provides an efficient method to identify new and uncharacterized candidate biomarkers of CV risk in HD patients.

  2. Survey of total error of precipitation and homogeneous HDL-cholesterol methods and simultaneous evaluation of lyophilized saccharose-containing candidate reference materials for HDL-cholesterol

    NARCIS (Netherlands)

    C.M. Cobbaert (Christa); H. Baadenhuijsen; L. Zwang (Louwerens); C.W. Weykamp; P.N. Demacker; P.G.H. Mulder (Paul)

    1999-01-01

    textabstractBACKGROUND: Standardization of HDL-cholesterol is needed for risk assessment. We assessed for the first time the accuracy of HDL-cholesterol testing in The Netherlands and evaluated 11 candidate reference materials (CRMs). METHODS: The total error (TE) of

  3. Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: “Herniated” HDL, a common feature in diabetes

    Science.gov (United States)

    Amigó, Núria; Mallol, Roger; Heras, Mercedes; Martínez-Hervás, Sergio; Blanco-Vaca, Francisco; Escolà-Gil, Joan Carles; Plana, Núria; Yanes, Óscar; Masana, Lluís; Correig, Xavier

    2016-01-01

    Recent studies have shown that pharmacological increases in HDL cholesterol concentrations do not necessarily translate into clinical benefits for patients, raising concerns about its predictive value for cardiovascular events. Here we hypothesize that the size-modulated lipid distribution within HDL particles is compromised in metabolic disorders that have abnormal HDL particle sizes, such as type 2 diabetes mellitus (DM2). By using NMR spectroscopy combined with a biochemical volumetric model we determined the size and spatial lipid distribution of HDL subclasses in a cohort of 26 controls and 29 DM2 patients before and after two drug treatments, one with niacin plus laropiprant and another with fenofibrate as an add-on to simvastatin. We further characterized the HDL surface properties using atomic force microscopy and fluorescent probes to show an abnormal lipid distribution within smaller HDL particles, a subclass particularly enriched in the DM2 patients. The reduction in the size, force cholesterol esters and triglycerides to emerge from the HDL core to the surface, making the outer surface of HDL more hydrophobic. Interestingly, pharmacological interventions had no effect on this undesired configuration, which may explain the lack of clinical benefits in DM2 subjects. PMID:26778677

  4. Impacto del CO2 sobre la densidad celular en seis cepas de microalgas marinas

    Directory of Open Access Journals (Sweden)

    Alberto I. Oscanoa Huaynate

    2015-12-01

    Full Text Available Debido a la gran facilidad con que las microalgas pueden capturar el CO2 del medio ambiente, resulta interesante evaluar la cantidad y tiempo de ingreso de éste a los cultivos masivos, con la fi nalidad de aumentar la densidad celular. El objetivo del presente estudio fue evaluar los tiempos de inyección del mencionado gas, durante la producción de biomasa que conlleve a una mayor densidad celular, evaluando además, la variación del pH sin alterar la calidad del cultivo. A partir de seis cepas obtenidas del Banco de Germoplasma del Instituto del Mar del Perú, se realizaron cultivos tipo batch de 300L en invernadero, el tiempo de cultivo de la fase exponencial donde se realizaron las pruebas fue de tres días. Los datos se procesaron mediante el análisis del parámetro pendiente de la regresión lineal. Los resultados mostraron que la densidad celular es inversamente proporcional al tiempo de inyección de CO2 al cultivo. La mayor densidad celular, en las diferentes cepas, se obtuvo a los 5min, excepto para las cepas Chaetoceros gracilisy Nannochloris maculata, las cuales obtienen la mayor densidad a los 10 y 15min, respectivamente. La variación de pH tendió hacia la acidez, en un rango de 8 a 4, sin alterar la densidad celular, por el contrario, los cultivos permanecieron libres de contaminantes. En conclusión, los resultados permiten establecer tiempos adecuados de inyección del CO2, los cuales fortalecen la fase de crecimiento exponencial aumentando la densidad poblacional en un 30% sobre lo establecido en esta fase.

  5. High efficiency motors; Motores de alta eficiencia

    Energy Technology Data Exchange (ETDEWEB)

    Uranga Favela, Ivan Jaime [Energia Controlada de Mexico, S. A. de C. V., Mexico, D. F. (Mexico)

    1992-12-31

    This paper is a technical-financial study of the high efficiency and super-premium motors. As it is widely known, more than 60% of the electrical energy generated in the country is used for the operation of motors, in industry as well as in commerce. Therefore the importance that the motors have in the efficient energy use. [Espanol] El presente trabajo es un estudio tecnico-financiero de los motores de alta eficiencia y los motores super premium. Como es ampliamente conocido, mas del 60% de la energia electrica generada en el pais, es utilizada para accionar motores, dentro de la industria y el comercio. De alli la importancia que los motores tienen en el uso eficiente de la energia.

  6. Impaired HDL function in obese adolescents: impact of lifestyle intervention and bariatric surgery.

    Science.gov (United States)

    Matsuo, Yae; Oberbach, Andreas; Till, Holger; Inge, Thomas H; Wabitsch, Martin; Moss, Anja; Jehmlich, Nico; Völker, Uwe; Müller, Ulrike; Siegfried, Wolfgang; Kanesawa, Norio; Kurabayashi, Masahiko; Schuler, Gerhard; Linke, Axel; Adams, Volker

    2013-12-01

    HDL regulates endothelial function via stimulation of nitric oxide production. It is documented that endothelial function is impaired in obese adolescents, and improved by lifestyle interventions (LI). HDL function in obese adolescents and the impact of LI or Roux-en-Y gastric bypass surgery (RYGB) was assessed. HDL was isolated from 14 adolescents with normal body mass index (HDLcontrol ), 10 obese (HDLobese ) before and after 6 month LI, and five severe obese adolescents before and one year after RYGB. HDL-mediated phosphorylation of endothelial nitric oxide synthase (eNOS)-Ser(1177) , eNOS-Thr(495) , and PKC-ßII was evaluated. In addition the HDL proteome was analyzed. HDLobese -mediated eNOS-Ser(1177) phosphorylation was reduced, whereas eNOS-Thr(495) phosphorylation increased significantly when compared to HDLcontrol . No impact of obesity was observed on PKC-ßII phosphorylation. LI and RYGB had no impact on HDL-mediated phosphorylation of eNOS and PKC-ßII. A principle component plot analysis of the HDL particle separated controls and severe obese, whereas the interventions did not trigger sufficient differences to the HDL proteome to permit distinction. These results demonstrated that HDL-function is impaired in obese adolescents, and that LI or RYGB did not correct this dysfunction. This might be an argument for developing earlier prevention strategies in obese adolescents to avoid HDL dysfunction. Copyright © 2013 The Obesity Society.

  7. Targeted next-generation sequencing to diagnose disorders of HDL cholesterol.

    Science.gov (United States)

    Sadananda, Singh N; Foo, Jia Nee; Toh, Meng Tiak; Cermakova, Lubomira; Trigueros-Motos, Laia; Chan, Teddy; Liany, Herty; Collins, Jennifer A; Gerami, Sima; Singaraja, Roshni R; Hayden, Michael R; Francis, Gordon A; Frohlich, Jiri; Khor, Chiea Chuen; Brunham, Liam R

    2015-10-01

    A low level of HDL cholesterol (HDL-C) is a common clinical scenario and an important marker for increased cardiovascular risk. Many patients with very low or very high HDL-C have a rare mutation in one of several genes, but identification of the molecular abnormality in patients with extreme HDL-C is rarely performed in clinical practice. We investigated the accuracy and diagnostic yield of a targeted next-generation sequencing (NGS) assay for extreme levels of HDL-C. We developed a targeted NGS panel to capture the exons, intron/exon boundaries, and untranslated regions of 26 genes with highly penetrant effects on plasma lipid levels. We sequenced 141 patients with extreme HDL-C levels and prioritized variants in accordance with medical genetics guidelines. We identified 35 pathogenic and probably pathogenic variants in HDL genes, including 21 novel variants, and performed functional validation on a subset of these. Overall, a molecular diagnosis was established in 35.9% of patients with low HDL-C and 5.2% with high HDL-C, and all prioritized variants identified by NGS were confirmed by Sanger sequencing. Our results suggest that a molecular diagnosis can be identified in a substantial proportion of patients with low HDL-C using targeted NGS. Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc.

  8. Características agronômicas da mamoneira afetadas pelo método de condução de plantas e densidade de semeadura

    Directory of Open Access Journals (Sweden)

    Samuel Luiz Fioreze

    Full Text Available RESUMO A cultura da mamona possui grande potencial para o cultivo em condições brasileiras, contudo, deve-se buscar métodos cada vez mais eficientes de manejo da cultura, a fim de atingir altas produtividades e introduzir de modo definitivo a cultura no sistema agrícola nacional. O objetivo do presente estudo foi avaliar as características agronômicas e a produtividade da mamoneira em função do método de condução de plantas e da densidade de cultivo. O estudo foi conduzido em condições de campo no ano agrícola de 2010, utilizando a cultivar IAC 2028, em delineamento experimental de blocos casualizados em esquema fatorial 2x3 com quatro repetições. O primeiro fator foi composto por duas densidades de semeadura (26666 e 111111 plantas ha-1, enquanto o segundo fator foi composto por três métodos de condução de plantas (testemunha, poda parcial e poda+desbrota. Ao final do desenvolvimento da cultura, foram determinadas as características agronômicas das plantas, os componentes da produção e a produtividade. A poda + desbrota proporcionou melhoria dos caracteres agronômicos, sem afetar a produtividade e reduziu o ciclo da cultura em até 30 dias. Este comportamento, aliado à maturação uniforme, pode proporcionar a colheita mecanizada da cultura, além de proporcionar o cultivo da mamoneira em janelas de cultivo na safrinha, sem prejudicar a implantação da safra seguinte. O cultivo adensado de plantas de mamona limitou a emissão de ramos produtivos secundários sem afetar a produtividade, revelando elevada plasticidade fenotípica no desenvolvimento da cultura.

  9. Avaliação da autozigosidade em vacas Nelore (Bos indicus) através de genótipos SNP de alta densidade

    OpenAIRE

    Zavarez, Ludmilla Balbo [UNESP

    2014-01-01

    The current beef cattle chain has had significant help of animal breeding programs to its success. The development of different methods to perform phenotypic and genotypic evaluation has the objective of selecting flocks and producing genetically superior animals with standardized production. The productive standardization of a herd must be the result of directed matings, which can lead to increased incidence of homozygous alleles in the genome of animals. The increase of autozygosity in the ...

  10. Compósitos de polietileno de alta densidade contendo hidroxissais e hidróxidos duplos lamelares intercalados com Ânions cloreto e corantes azo

    OpenAIRE

    Zimmermann, Ademir

    2014-01-01

    Resumo: A busca constante por novos materiais tem chamado atenção dos pesquisadores em todo o mundo, com destaque aos nanocompósitos envolvendo matrizes poliméricas com características hidrofóbicas. A incorporação de cargas lamelares funcionais hidrofílicas nestas matrizes apresenta problemas de incompatibilidade, sendo de grande interesse o estudo da modificação química da superfície das cargas lamelares no sentido de melhorar a sua compatibilidade e consequentemente aperfeiçoar as proprieda...

  11. Evaporation of carbon using electrons of a high density plasma; Evaporacion de carbono usando los electrones de un plasma de alta densidad

    Energy Technology Data Exchange (ETDEWEB)

    Muhl, S.; Camps, E.; Escobar A, L.; Garcia E, J.L.; Olea, O. [Instituto de Investigaciones en Materiales, UNAM, C.P. 04510 Mexico D.F. (Mexico)

    2000-07-01

    The high density plasmas are used frequently in the preparation of thin films or surface modification, for example to nitridation. In these processes, are used mainly the ions and the neutrals which compose the plasma. However, the electrons present in the plasma are not used, except in the case of chemical reactions induced by collisions, although the electron bombardment usually get hot the work piece. Through the adequate polarization of a conductor material, it is possible to extract electrons from a high density plasma at low pressure, that could be gotten the evaporation of this material. As result of the interaction between the plasma and the electron flux with the vapor produced, this last will be ionized. In this work, it is reported the use of this novelty arrangement to prepare carbon thin films using a high density argon plasma and a high purity graphite bar as material to evaporate. It has been used substrates outside plasma and immersed in the plasma. Also it has been reported the plasma characteristics (temperature and electron density, energy and ions flux), parameters of the deposit process (deposit rate and ion/neutral rate) as well as the properties of the films obtained (IR absorption spectra and UV/Vis, elemental analysis, hardness and refractive index). (Author)

  12. Study of steatites for using as a high density resistor nucleus; Estudo de esteatito para utilizacao como nucleo de resistor de alta densidade

    Energy Technology Data Exchange (ETDEWEB)

    Salas, Humberto Terrazas; Costa, Antonio Carlos Lopes da; Barbosa, Joao Batista Santos; Silva, Luiz Carlos da; Rocha, Francisco de Assis [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Belo Horizonte, MG (Brazil)]. E-mail: salasht@cdtn.br

    2005-07-01

    In nuclear facilities where high density power resistors are applied in fuel irradiation circuits in the PWR reactor type, the probability of accident is high, therefore, it is necessary to experimentally test the nuclear facility safety project. In order to reach this goal, it is necessary to use an electric isolated material capable of withstanding high temperatures without melting or becoming deteriorated. That is where the lytologic type, classified as steatite or soapstone, must be used. The present work characterizes the steatite samples, suggesting the lytologic type to be used as the high density power resistors nucleus. Samples were selected from a steatite' processing industry located in the district of Cachoeira do Campo in Minas Gerais State. These lytologic types were sawed, evaluated macroscopically, subjected to specific preparation methods for chemical analysis and X rays diffraction, exposed to high temperatures, as well as petrographic studies and microanalyses. Samples marked by lower concentration levels of carbonates. (author)

  13. World Wide Web Search Engines: AltaVista and Yahoo.

    Science.gov (United States)

    Machovec, George S., Ed.

    1996-01-01

    Examines the history, structure, and search capabilities of Internet search tools AltaVista and Yahoo. AltaVista provides relevance-ranked feedback on full-text searches. Yahoo indexes Web "citations" only but does organize information hierarchically into predefined categories. Yahoo has recently become a publicly held company and…

  14. Low Levels of HDL in Fragile X Syndrome Patients.

    Science.gov (United States)

    Lisik, Małgorzata Z; Gutmajster, Ewa; Sieroń, Aleksander L

    2016-02-01

    Fragile X syndrome (FXS) is the most common form of familial mental retardation and one of the leading known causes of autism. The mutation responsible for FXS is a large expansion of the CGG repeats in the promoter region of the FMR1 gene resulting in the transcriptional silencing of the gene in the pathophysiology of Fragile X syndrome was hypothesized. 23 male patients affected by Fragile X syndrome (full mutation in the FMR1 gene) and 24 controls were included in the study. The serum levels of HDL-C were lower in FXS patients (p < 0.001). The serum levels triacylglycerols were higher in FXS patients (p = 0.007) Further study involving larger samples are necessary to confirm the results and define the health implications for abnormal lipid levels in FXS patients.

  15. Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population

    DEFF Research Database (Denmark)

    Frikke-Schmidt, Ruth; Nordestgaard, Børge G; Jensen, Gorm B

    2004-01-01

    or single-nucleotide polymorphisms (SNPs) in ABCA1 were overrepresented in individuals with the lowest 1% (n=95) or highest 1% (n=95) HDL-C levels in the general population by screening the core promoter and coding region of ABCA1. For all nonsynonymous SNPs identified, we determined the effect of genotype......Homozygosity for mutations in ABC transporter A1 (ABCA1) causes Tangier disease, a rare HDL-deficiency syndrome. Whether heterozygosity for genetic variation in ABCA1 also contributes to HDL cholesterol (HDL-C) levels in the general population is presently unclear. We determined whether mutations...... on lipid traits in 9,259 individuals from the general population. Heterozygosity for ABCA1 mutations was identified in 10% of individuals with low HDL-C only. Three of 6 nonsynonymous SNPs (V771M, V825I, and R1587K) were associated with increases or decreases in HDL-C in women in the general population...

  16. Estudo longitudinal da densidade mineral óssea de cães Golden Retriever hígidos, portadores e afetados pela distrofia muscular

    Directory of Open Access Journals (Sweden)

    Robson Fortes Giglio

    2009-10-01

    Full Text Available A Distrofia Muscular do Golden Retriever (GRMD é considerada o modelo mais apropriado da Distrofia Muscular de Duchenne (DMD que acomete humanos. Diminuição na Densidade Mineral Óssea (DMO já foi descrita em meninos com DMD, ambulantes e não-ambulantes. A Densitometria Óptica Radiográfica (DOR é um método de análise para quantificação da matéria mineral óssea. Este foi realizado por meio de radiografias simples da região proximal da tíbia direita ao lado de escala de alumínio. Quinze cães da raça Golden Retriever, sendo cinco normais, cinco portadores e cinco afetados pela distrofia, foram radiografados mensalmente, dos três aos nove meses de idade. Estas radiografias foram analisadas por meio do software de análise de imagens (ImageLab, Softium®. O estudo revelou que a região epifisária possui maior densidade mineral óssea (DMO, seguida pela região metafisária e diafisária. Houve uma tendência de aumento da DMO nas três regiões avaliadas dos três grupos durante o experimento. A região metafisária proximal da tíbia demonstrou ser o sitio de eleição para a leitura da DMO, por ser o local com menor correlação e influencia do peso corpóreo e por promover estimativas médias consideradas significativas entre grupos avaliados mais cedo que nas demais regiões. O potencial de diagnóstico deste exame densitométrico, em relação a GRMD, foi considerado baixo, porém, demonstrou ter grande potencial no acompanhamento do progresso desta doença por apresentar alta sensibilidade para detecção de variações na densidade mineral óssea.

  17. Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III.

    Science.gov (United States)

    Koch, Manja; Furtado, Jeremy D; Jiang, Gordon Z; Gray, Brianna E; Cai, Tianxi; Sacks, Frank; Tjønneland, Anne; Overvad, Kim; Jensen, Majken K

    2017-06-01

    The presence of apoC-III on HDL impairs HDL's inverse association with coronary heart disease (CHD). Little is known about modifiable factors explaining variation in HDL subspecies defined according to apoC-III. The aim was to investigate cross-sectional associations of anthropometry and lifestyle with HDL subspecies in 3,631 participants from the Diet, Cancer, and Health study originally selected for a case-cohort study (36% women; age 50-65 years) who were all free of CHD. Greater adiposity and less activity were associated with higher HDL containing apoC-III and lower HDL lacking apoC-III. Per each 15 cm higher waist circumference, the level of HDL containing apoC-III was 2.8% higher (95% CI: 0.4, 5.3; P = 0.024) and the level of HDL not containing apoC-III was 4.7% lower (95% CI: -6.0, -3.4; P = <0.0001). Associations for physical activity were most robust to multivariable modeling. Each 20 metabolic equivalent task hours per week reported higher physical activity was associated with 0.9% (95% CI: -1.7, -0.1; P = 0.031) lower HDL containing apoC-III and 0.5% higher (95% CI: 0.1, 1.0; P = 0.029) HDL lacking apoC-III. Lower alcohol consumption was associated with lower HDL lacking apoC-III (percent difference per 15 g/day: 1.58 (95% CI: 0.84, 2.32; P = <0.0001). Adiposity and sedentary lifestyle were associated with a less favorable HDL subspecies profile. Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

  18. Turismo em territórios de grande densidade religiosa

    Directory of Open Access Journals (Sweden)

    Siegrid Guillaumon

    2012-12-01

    Full Text Available Resumo ----- O turismo tem sido entendido por organismos internacionais como atividade com grande potencial para promover o desenvolvimento econômico e, ao mesmo tempo, que valoriza a cultura e promove a preservação das paisagens naturais. Seguindo as diretrizes internacionais, no Brasil, o turismo passou a ser entendido como uma indústria com grande potencial para gerar empregos e divisas, e se fortalece por meio da promoção da diversidade cultural, que pode estar associada às diversas culturas materiais e religiosas. Para compreender a gestão do turismo em contextos que articulam cultura, religião e desenvolvimento territorial, este ensaio teórico aponta limitações nos dois conceitos disponíveis na literatura, quais sejam, o conceito de turismo cultural e o conceito de turismo religioso, ao mesmo tempo que propõe o conceito de ‘turismo em territórios de grande densidade religiosa’, o qual incorpora o reconhecimento das dinâmicas de poder presentes nos territórios como elementos que interferem na forma como se planeja o turismo. Mobilizam-se entendimentos do campo da antropologia e da geografi a para a gestão a fim de sustentar que a discussão teórica conduzida tem um potencial explicativo para o turismo em diversas escalas territoriais, e, também, em contextos nos quais existe o diálogo entre turismo e religião. ----- Tourism in Territories of High Religious Density ----- Abstract ----- Tourism has been understood by international organizations as an activity with great potential to promote economic development, while valuing cultures and promoting the protection of natural landscapes. Following international guidelines, tourism in Brazil has begun to be understood as an industry with great potential to generate jobs and income and is strengthened through the promotion of cultural diversity which may be associated with material and religious cultures. To understand the management of tourism in contexts that

  19. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

    DEFF Research Database (Denmark)

    Elsøe, Sara; Ahnström, Josefin; Christoffersen, Christina

    2012-01-01

    Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lip...... a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL....

  20. Advances in the Study of the Antiatherogenic Function and Novel Therapies for HDL

    Directory of Open Access Journals (Sweden)

    Peiqiu Cao

    2015-07-01

    Full Text Available The hypothesis that raising high-density lipoprotein cholesterol (HDL-C levels could improve the risk for cardiovascular disease (CVD is facing challenges. There is multitudinous clear clinical evidence that the latest failures of HDL-C-raising drugs show no clear association with risks for CVD. At the genetic level, recent research indicates that steady-state HDL-C concentrations may provide limited information regarding the potential antiatherogenic functions of HDL. It is evident that the newer strategies may replace therapeutic approaches to simply raise plasma HDL-C levels. There is an urgent need to identify an efficient biomarker that accurately predicts the increased risk of atherosclerosis (AS in patients and that may be used for exploring newer therapeutic targets. Studies from recent decades show that the composition, structure and function of circulating HDL are closely associated with high cardiovascular risk. A vast amount of data demonstrates that the most important mechanism through which HDL antagonizes AS involves the reverse cholesterol transport (RCT process. Clinical trials of drugs that specifically target HDL have so far proven disappointing, so it is necessary to carry out review on the HDL therapeutics.

  1. Notes about Alta Vista in Chalchihuites, Zacatecas

    Science.gov (United States)

    Montero García, Ismael Arturo

    2016-11-01

    The Tropic of Cancer is a parallel located at the latitude of 23°26'16''. This imaginary line extends across northern Mexico from the southernmost point of the Baja California Peninsula, to the Gulf of Mexico, passing through the states of Baja California Sur, Sinaloa, Durango, Zacatecas, San Luis Potosí, Nuevo León and Tamaulipas. The Tropic of Cancer marks the northernmost position of the sun at its midday zenith, which takes place in the Summer solstice. On this day, the sun's rays hit the earth's surface vertically along the entire length of this latitude, which was supposed to be significant for the priest/astronomers of ancient times, who dedicated themselves to observing the apparent movements of the sun. It so happens that Alta Vista in Zacatecas, corresponds to the westernmost peak where this phenomenon can occur, although the date of the zenith's course differs depending on the latitude of each position and so various archaeoastronomical specialists stress how the ancient indigenous cultures, at least those dating from Mexico's Classical period, valued this finding in developing their calendars. On the other hand, the research contributes new elements for discussion because it presents a calendar of the horizon, based on of the highest peaks of the Sierra Prieta mountain range ranging from the archaeological sites of El Chapín, Cerro Pedregoso, to the excavations at El Picacho Pelón (peak El Pelón).

  2. Atherogenic Impact of Lecithin-Cholesterol Acyltransferase and Its Relation to Cholesterol Esterification Rate in HDL (FERHDL) and AIP [log(TG/HDL-C)] Biomarkers: The Butterfly Effect?

    Czech Academy of Sciences Publication Activity Database

    Dobiášová, Milada

    2017-01-01

    Roč. 66, č. 2 (2017), s. 193-203 ISSN 0862-8408 Institutional support: RVO:67985823 Keywords : lecithin-cholesterol acyltransferase (LCAT) * atherosclerosis * FERHDL (fractional esterification rate in HDL) * AIP (atherogenic index of plasma, log(TG/HDL-C) * biomarkers of cardiometabolic risk * lipoprotein particle size Subject RIV: FA - Cardiovascular Disease s incl. Cardiotharic Surgery OBOR OECD: Endocrinology and metabolism (including diabetes, hormones) Impact factor: 1.461, year: 2016

  3. Creatividad, personalidad y competencia socio-emocional en alumno de altas habilidades versus no altas habilidades

    OpenAIRE

    Sainz Gómez, Marta

    2010-01-01

    El trabajo pretende estudiar la relación entre rasgos de personalidad, creatividad y competencias socio-emocionales en función de la capacidad cognitiva (alta, media y baja inteligencia). En el trabajo empírico han participado 679 estudiantes de 12 y 18 años. Los instrumentos utilizados para evaluar las distintas áreas fueron: a) inteligencia psicométrica (Test de Aptitudes Diferenciales, DAT-5); b) creatividad (Test de Pensamiento Creativo de Torrance, TTCT); c) Competencias socio-emoci...

  4. High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study.

    Science.gov (United States)

    Arts, Elke; Fransen, Jaap; Lemmers, Heidi; Stalenhoef, Anton; Joosten, Leo; van Riel, Piet; Popa, Calin D

    2012-05-14

    Higher levels of high density lipoprotein (HDL) subfractions HDL3-chol and particularly HDL2-chol protect against cardiovascular disease (CVD), but inflammation reduces the HDL level and may impair its anti-atherogenic effect. Changed HDL composition through the impact of inflammation on HDL subfractions may contribute to the excess risk of CVD in rheumatoid arthritis (RA). In this study, we investigated whether HDL2-chol and HDL3-chol concentrations differ between RA patients and healthy controls, and whether these levels are related to the level of RA disease activity. Non-fasting blood samples were collected from 45 RA patients and 45 healthy controls. None of the participants had a history of CVD, diabetes, or used lipid-lowering drugs. HDL2-chol and HDL3-chol concentrations were obtained by ultracentrifugation. Regression modeling was used to compare HDL subfraction levels between RA patients and healthy controls, and to analyze the effect of disease activity on HDL2-chol and HDL3-chol. HDL2-chol and HDL3-chol were significantly lower in RA patients compared to healthy controls (P = 0.01, P = 0.005, respectively). The HDL2:HDL3 ratio was significantly lower in patients compared to controls (P = 0.04). Reduced HDL2-chol and HDL3-chol levels were primarily present in female RA patients and not in male RA patients. A modest effect of the disease activity score in 28 joins ( DAS28) on HDL2-chol concentrations was found, after correction for disease duration, glucocorticosteroid use and body mass index (BMI), with a 0.06 mmol/L decrease with every point increase in DAS28 (P = 0.05). DAS28 did not significantly affect HDL3-chol concentrations (P = 0.186). Both HDL subfractions but particularly HDL2-chol concentrations were decreased in RA, primarily in women. This seems to be associated with disease activity and is of clinical relevance. The reduction of the HDL subfraction concentrations, particularly the supposedly beneficial HDL2-chol, may negatively impact the

  5. Prevalence of low HDL cholesterol, and relationship between serum HDL and cardiovascular disease in elderly Spanish population: the PREV-ICTUS study.

    Science.gov (United States)

    Cea-Calvo, L; Lozano, J V; Fernández-Pérez, C; Llisterri, J L; Martí-Canales, J C; Aznar, J; Gil-Guillén, V; Redón, J

    2009-01-01

    To assess the prevalence of low serum high-density lipoprotein cholesterol (HDL-C) concentration and the relationship between HDL-C and established cardiovascular disease (CVD) in an elderly Mediterranean population. Analysis of Prevención del Riesgo de Ictus, a population-based study on Spanish subjects aged > or = 60 years. Low HDL-C was defined following the European guidelines for cardiovascular prevention [men: 65 mg/dl (> 1.67 mmol/l)], adjusted OR for CVD were 1.39 (1.10-1.76), 1.41 (1.11-1.80), 1.49 (1.18-1.89) and 1.91 (1.52-2.39), respectively for those in the fourth [57-65 mg/dl (1.46-1.67 mmol/l)], third [51-56 mg/dl (1.31-1.45 mmol/l)], second [46-50 mg/dl (1.18-1.30 mmol/l)] and first [ or = 60 years had low HDL-C. We found a strong, independent and inverse association between HDL-C concentrations and established CVD, even at ranges of HDL-C considered as normal.

  6. Caracterización de la composición y fluctuaciones en la densidad y diversidad de los ensambles planctónicos en cuatro humedales de Tarapacá

    Directory of Open Access Journals (Sweden)

    Esteban Quinan

    2016-12-01

    Full Text Available La limnología de los humedales interiores en Tarapacá presenta ciclos productivos altamente dependientes de las lluvias estivales y las condiciones fisicoquímicas del medio. Entre 2013 y 2015 se estudiaron ensambles planctónicos de dos lagunas de evaporación y dos quebradas, durante dos temporadas productivas y dos vegetativas, junto con esto se observaron las condiciones fisicoquímicas asociadas. Los resultados mostraron que el fitoplancton en general estuvo dominado por diatomeas y solo en una quebrada por algas verdes, mientras que el zooplancton presentó composiciones muy distintas entre las lagunas y entre las quebradas, con importantes variaciones temporales. En lagunas las densidades altas de zooplancton asociaron positivamente con sólidos disueltos totales y su diversidad inversamente con la temperatura, por su parte la diversidad de fitoplancton mantuvo una relación inversa con la riqueza de zooplancton.

  7. Avaliação da macroporosidade e da densidade de partículas do solo através da microtomografia de raios-x

    Directory of Open Access Journals (Sweden)

    A. Macedo

    1999-12-01

    Full Text Available A Ciência do Solo procura compreender e modelar os fenômenos ocorridos no solo, principalmente na zona não saturada. Como o entendimento de muitos desses fenômenos exige determinações em escalas que permitam incorporar aos modelos a variabilidade de poros e agregados, desenvolveu-se, na Embrapa Instrumentação Agropecuária, um tomógrafo de raios-X, de resolução micrométrica, com o objetivo de se obterem imagens, de forma não-destrutiva, de amostras de solo, com resolução espacial igual ou inferior a 100 μm. Foi possível projetar e construir um equipamento, de alta resolução, com baixo custo, comparativamente aos equipamentos comerciais disponíveis, cujos preços são proibitivos para aplicações em solo. Obtiveram-se imagens de amostras de solos com estrutura deformada, compostos por agregados de 212 a 250 μm, nos quais foram identificados poros medindo 100 μm ou menos. Poros dessas dimensões foram visualizados, também, em tomografias de amostras compostas de grãos de areia de 1 mm e capilares de vidro com diâmetros internos de 100, 200 e 300 μm. Tomografias de amostras não deformadas de solos evidenciaram, além de poros de 200 a 800 μm, partículas de alta densidade não-detectáveis com a tomografia de resolução milimétrica.

  8. Reconfiguración del territorio y política territorial: Dispersión y baja densidad en las áreas de crecimiento reciente de la ciudad de Tandil, provincia de Buenos Aires

    Directory of Open Access Journals (Sweden)

    Licia Ríos

    2014-06-01

    Full Text Available En el marco del fenómeno de urbanización creciente, se verifican cambios en la configuración territorial que dan cuenta de la emergencia de procesos de expansión urbana dispersos en coexistencia con las tradicionales formas de gradiente por periferización del modelo de ciudad compacta. Tanto en la reestructuración territorial de las áreas metropolitanas como de las ciudades de menor rango, se manifiestan cambios específicos caracterizados por dinámicas demográficas y económicas intensas, en correspondencia con significativas transformaciones de los entornos periurbanos y rurales. El estudio del crecimiento urbano en la ciudad de Tandil busca explicar las relaciones entre las reconfiguraciones ocurridas en las áreas de crecimiento urbano reciente, y la planificación y gestión territorial. La tesis que subyace es que la política territorial favoreció las tendencias de expansión urbana dispersas y de baja densidad, en articulación con las dinámicas del mercado de suelos rururbanos y nuevas demandas socioculturales. La política territorial ha tenido una alta capacidad de incidencia en la configuración del territorio a partir del reconocimiento de nuevas tendencias, fundamentalmente las asociadas al crecimiento extensivo, disperso y de baja densidad, porque sus acciones y decisiones validan los nuevos modelos.

  9. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

    DEFF Research Database (Denmark)

    Postmus, Iris; Warren, Helen R; Trompet, Stella

    2016-01-01

    BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation. METHODS AND RESULTS: We perform...

  10. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

    DEFF Research Database (Denmark)

    Christoffersen, Christina; Obinata, Hideru; Kumaraswamy, Sunil B

    2011-01-01

    Protection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P), which maintains vascular integrity. We show that HDL-associated S1P is bound specifically to both human and murine apolipoprotein M (apoM). Thus, isolated human ApoM(+) HDL contained S1P, whereas ApoM(-) HDL did...... not. Moreover, HDL in Apom(-/-) mice contains no S1P, whereas HDL in transgenic mice overexpressing human apoM has an increased S1P content. The 1.7-Å structure of the S1P-human apoM complex reveals that S1P interacts specifically with an amphiphilic pocket in the lipocalin fold of apoM. Human ApoM......(+) HDL induced S1P(1) receptor internalization, downstream MAPK and Akt activation, endothelial cell migration, and formation of endothelial adherens junctions, whereas apoM(-) HDL did not. Importantly, lack of S1P in the HDL fraction of Apom(-/-) mice decreased basal endothelial barrier function in lung...

  11. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

    NARCIS (Netherlands)

    D. Postmus (Douwe); H. Warren (Helen); S. Trompet (Stella); B.J. Arsenault (Benoit J.); C.L. Avery; J.C. Bis (Joshua); D.I. Chasman (Daniel); C.E. de Keyser (Catherina Elisabeth); H. Deshmukh (Harshal); D.S. Evans (Daniel); Feng, Q. (QiPing); X. Li (Xiaohui); Smit, R.A.J. (Roelof A.J.); A.V. Smith (Albert Vernon); F. Sun (Fangui); K.D. Taylor (Kent); A.M. Arnold (Alice M.); M.J. Barnes (Michael); B.J. Barratt (Bryan J.); J. Betteridge (John); S.M. Boekholdt (Matthijs); E.A. Boerwinkle (Eric); B.M. Buckley (Brendan M.); Y.D. Chen (Y.); A.J. de Craen (Anton); S. Cummings; Denny, J.C. (Joshua C.); G.P. Dubé (Gregory); P.N. Durrington (Paul); G. Eiriksdottir (Gudny); I. Ford (Ian); X. Guo (Xiuqing); T.B. Harris (Tamara); S.R. Heckbert (Susan); A. Hofman (Albert); G. Kees Hovingh; J.J.P. Kastelein (John); Launer, L.J. (Leonore J.); Liu, C.-T. (Ching-Ti); Y. Liu (YongMei); T. Lumley (Thomas); P.M. Mckeigue (Paul); P. Munroe (Patricia); A. Neil (Andrew); D.A. Nickerson (Deborah); F. Nyberg (Fredrik); E. O'Brien (Eoin); C.J. O'Donnell (Christopher); W.S. Post (Wendy S.); N.R. Poulter (Neil); R.S. Vasan (Ramachandran Srini); K.M. Rice (Kenneth); S.S. Rich (Stephen); F. Rivadeneira Ramirez (Fernando); N. Sattar (Naveed); P. Sever (Peter); S. Shaw-Hawkins (Sue); D.C. Shields (Denis C.); P.E. Slagboom (Eline); N.L. Smith (Nicholas); J.D. Smith (Joshua D.); N. Sotoodehnia (Nona); A. Stanton (Alice); D.J. Stott (David. J.); B.H.Ch. Stricker (Bruno); T. Stürmer; A.G. Uitterlinden (André); W.-Q. Wei (Wei-Qi); R.G.J. Westendorp (Rudi); E.A. Whitsel (Eric A.); K.L. Wiggins (Kerri); R.A. Wilke (Russell A.); C. Ballantyne (Christie); H.M. Colhoun (H.); L.A. Cupples (Adrienne); O.H. Franco (Oscar); V. Gudnason (Vilmundur); G.A. Hitman (Graham); C.N.A. Palmer (Colin); B.M. Psaty (Bruce); P.M. Ridker (Paul); J.M. Stafford (Jeanette M.); Stein, C.M. (Charles M.); J.-C. Tardif (Jean-Claude); M. Caulfield (Mark); J.W. Jukema (Jan Wouter); Rotter, J.I. (Jerome I.); R.M. Krauss (Ronald)

    2016-01-01

    textabstractBackground In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Interindividual variation in HDL-C response to statins may be partially explained by genetic variation. Methods and results We

  12. Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice.

    Directory of Open Access Journals (Sweden)

    Matteo Pedrelli

    Full Text Available OBJECTIVES: ACAT2 is the exclusive cholesterol-esterifying enzyme in hepatocytes and enterocytes. Hepatic ABCA1 transfers unesterified cholesterol (UC to apoAI, thus generating HDL. By changing the hepatic UC pool available for ABCA1, ACAT2 may affect HDL metabolism. The aim of this study was to reveal whether hepatic ACAT2 influences HDL metabolism. DESIGN: WT and LXRα/β double knockout (DOKO mice were fed a western-type diet for 8 weeks. Animals were i.p. injected with an antisense oligonucleotide targeted to hepatic ACAT2 (ASO6, or with an ASO control. Injections started 4 weeks after, or concomitantly with, the beginning of the diet. RESULTS: ASO6 reduced liver cholesteryl esters, while not inducing UC accumulation. ASO6 increased hepatic ABCA1 protein independently of the diet conditions. ASO6 affected HDL lipids (increased UC only in DOKO, while it increased apoE-containing HDL in both genotypes. In WT mice ASO6 led to the appearance of large HDL enriched in apoAI and apoE. CONCLUSIONS: The use of ASO6 revealed a new pathway by which the liver may contribute to HDL metabolism in mice. ACAT2 seems to be a hepatic player affecting the cholesterol fluxes fated to VLDL or to HDL, the latter via up-regulation of ABCA1.

  13. The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?

    NARCIS (Netherlands)

    Vergeer, Menno; Holleboom, Adriaan G.; Kastelein, John J. P.; Kuivenhoven, Jan Albert

    2010-01-01

    There is unequivocal evidence of an inverse association between plasma high-density lipoprotein (HDL) cholesterol concentrations and the risk of cardiovascular disease, a finding that has led to the hypothesis that HDL protects from atherosclerosis. This review details the experimental evidence for

  14. Abnormalities in lipoprotein metabolism: from dysfunctional HDL to abnormal processing of triglyceride rich lipoproteins

    NARCIS (Netherlands)

    Franssen, R.

    2010-01-01

    Remco Franssen bestudeerde de rol van HDL, van nature gezien als het goede cholesterol, in ontstekingsprocessen en in het reverse cholesterol transport. Het kunstmatige rHDL is in staat de gevolgen van een stijging van het ontstekingseiwit CRP te voorkomen. Een chronische ontsteking als reuma of de

  15. Formas funcionales del potencial y la densidad electrónica para grafeno delta dopado

    Directory of Open Access Journals (Sweden)

    Francisco J. López-Rodríguez

    2013-01-01

    Full Text Available Establecemos las bases para el estudio del efecto de una línea extendida de impurezas sobre una placa d e grafeno. Mediante el uso de análisis dimensional y la propuesta de una ecuación de Poisson bidimensional, obtenemos las formas funcionales del potencial y la densidad electrónica de este problema.

  16. Densidade de estocagem na engorda de camarão-branco cultivado em sistema de biofloco

    Directory of Open Access Journals (Sweden)

    Charles Fróes

    2013-08-01

    Full Text Available O objetivo deste trabalho foi determinar a densidade de estocagem ideal para o cultivo de camarão-branco, em sistema de biofloco sem renovação de água. Foram realizados dois experimentos inteiramente casualizados, com três repetições para cada tratamento. No primeiro, juvenis de camarão-branco, com peso médio inicial de 1,23±0,09 g, foram cultivados a densidades de estocagem de 833, 1.250, 1.667, 2.083 e 2.500 camarões por m³. No segundo experimento, o peso médio inicial foi de 6,32±0,7 g, e as densidades foram de 566, 833, 1.111, 1.388 e 1.667 camarões por m³. Os melhores resultados de produtividade, com médias de 9,92 e 10,77 kg m-3, foram obtidos com 1.667 e 1.111 camarões por m³, respectivamente, no primeiro e segundo experimentos. O aumento da densidade de estocagem afeta o crescimento e a sobrevivência do camarão-branco em sistema de biofloco.

  17. In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models

    DEFF Research Database (Denmark)

    Pérez-Medina, Carlos; Binderup, Tina; Lobatto, Mark E

    2016-01-01

    OBJECTIVES: The goal of this study was to develop and validate a noninvasive imaging tool to visualize the in vivo behavior of high-density lipoprotein (HDL) by using positron emission tomography (PET), with an emphasis on its plaque-targeting abilities. BACKGROUND: HDL is a natural nanoparticle......,2-distearoyl-sn-glycero-3-phosphoethanolamine-deferoxamine B). Biodistribution and plaque targeting of radiolabeled HDL were studied in established murine, rabbit, and porcine atherosclerosis models by using PET combined with computed tomography (PET/CT) imaging or PET combined with magnetic resonance imaging......-injection for both (89)Zr-HDL nanoparticles. In the porcine model, increased accumulation of radioactivity was observed in lesions by using in vivo PET imaging. Irrespective of the radiolabel's location, HDL nanoparticles were able to preferentially target plaque macrophages and monocytes. CONCLUSIONS: (89)Zr...

  18. The ALTA global positioning satellite based timing system

    CERN Document Server

    Brouwer, W; Caron, B; Hewlett, J C; Holm, L; Hamilton, A H; McDonald, W J; Pinfold, J L; Schaapman, J R; Soluk, R A; Wampler, L J

    2002-01-01

    The Alberta Large-area Time-coincidence Array (ALTA) experiment uses a number of scintillation detector systems to form a sparse very large area cosmic air-shower detection array. An important scientific goal of the ALTA collaboration is to search for coincidences in the ALTA array due to large area cosmic ray phenomena. A local cosmic ray event, determined by a coincidence of the triplet of cosmic ray detectors forming a local detector system, is time stamped with a temporal coordinate obtained from a GPS receiver. The readout of the data, the local coincidence and the GPS time stamp are all performed in the local readout crate. This time stamp, along with the local shower direction is used to search for coincidences within the large area array. Using two GPS receivers and duplicate sets of ALTA electronics the timing resolution of the GPS time difference between sites was estimated to be 16 ns.

  19. Alta Capital venitab Kruudale tasumisega / Sten-Aleks Pihlak

    Index Scriptorium Estoniae

    Pihlak, Sten-Aleks

    2008-01-01

    Alta Capital Partnersid pole veel maksnud Oliver Kruudale 2007. aasta septembris müüdud Tere ja Kalevi eest. Vt. samas: Rahasaamise venimine on lükanud Kalevi viimastel kuudel laenurallile. Kommenteerib Aivar Häelm

  20. Produção de cebola cultivada sob diferentes densidades de plantio

    Directory of Open Access Journals (Sweden)

    Gabrielly P. de S. A. Henriques

    2014-07-01

    Full Text Available Propôs-se, neste trabalho, avaliar o desempenho agronômico da cebola em diferentes densidades de plantio, em Mossoró, RN. O delineamento experimental utilizado foi em blocos casualizados completos em esquema fatorial 2 x 5, com quatro repetições. Os tratamentos consistiram da combinação de duas cultivares de cebola (Vale Ouro IPA 11 e Bella Dura e cinco densidades de plantio (80, 120, 160, 200 e 240 plantas m-2. As características avaliadas foram: classificação dos bulbos em função do diâmetro transversal; produtividade total, comercial e não comercial; massa média dos bulbos; massa seca dos bulbos e relação do formato de bulbos. A cultivar mais produtiva foi a IPA 11, com produtividade total de 26,76 t ha-1. A densidade que proporcionou maior produtividade total (30,48 t ha-1 foi a de 204 plantas m-2 e comercial (24,74 t ha-1 foi a de 161 plantas m-2. O incremento da densidade reduziu a massa média e seca de bulbo, percentagem de bulbos das classes 2 e 3, mas aumentou a produtividade não comercial, percentagem de bulbos classe 1 (refugo e relação de formato de bulbo. A cultivar Vale Ouro IPA 11 foi superior ao híbrido Bella Dura com relação à produtividade total de bulbos, massa média de bulbos comerciais e relação de formato, independentemente da densidade de plantio.

  1. Comportamento de cultivares de cafeeiro em diferentes densidades de plantio The behavior of coffee cultivars under different plant densities

    Directory of Open Access Journals (Sweden)

    Edison Martins Paulo

    2005-01-01

    Full Text Available Avaliou-se em Adamantina, na Região da Alta Paulista, em São Paulo, entre maio de 1995 e junho de 2000, o crescimento e quatro produções de cafeeiros das cultivares de porte baixo Catuaí Amarelo IAC 47 e Obatã IAC 1669-20 de Coffea arabica L., submetidas às densidades de plantio de 2.500, 5.000, 7.519 e 10.000 plantas ha-1, com uma planta por cova. Estudou-se também a população de 2.500 plantas.ha-1 em covas com duas plantas com 2,0 m de distância na linha de plantio. Adotou-se o delineamento estatístico de blocos ao acaso com três repetições, com parcelas subdivididas, onde as parcelas foram as populações e as subparcelas, as cultivares. Os resultados permitiram inferir que, no período estudado, o aumento da densidade influenciou positivamente a altura e negativamente o diâmetro do caule e da base da copa dos cafeeiros, mas não a altura da inserção do primeiro ramo plagiotrópico a partir do nível do solo. O aumento da população de cafeeiros acarretou menor produção de café beneficiado por planta, mas concorreu para o aumento da produtividade no período de 1997 a 2000. O plantio de duas mudas de café por cova acarretou também diminuição do diâmetro do caule e da produção individual dos cafeeiros. Observou-se na cultivar Catuaí Amarelo IAC 47 maior diâmetro da base da copa e maior crescimento em altura, enquanto a cv. Obatã IAC 1669-20 evidenciou seu maior diâmetro do caule. As cultivares Catuaí Amarelo IAC 47 e Obatã IAC 1669-20 não diferiram entre si quanto à produção individual e à produtividade de café beneficiado no quadriênio (1997-2000.This experiment was developed at Adamantina, west region of the State of São Paulo, Brazil, during May of 1995 to June of 2000. The plant growth and productivity of two coffee cultivars Catuaí Amarelo IAC 47 and Obatã IAC 1669-20, were evaluated considering to plant densities of 2.500, 5.000, 7.519 and 10.000 plants ha-1. The density of 2500 also was

  2. Glycation of human high density lipoprotein by methylglyoxal: effect on HDL-paraoxonase activity.

    Science.gov (United States)

    Bacchetti, Tiziana; Masciangelo, Simona; Armeni, Tatiana; Bicchiega, Virginia; Ferretti, Gianna

    2014-03-01

    Methylglyoxal (MG), a reactive carbonyl compound formed primarily from triose phosphates, appears to be involved in the molecular mechanisms of diabetes, end-stage renal disease and neurodegenerative diseases. Methylglyoxal exerts several biological activities. Among these it promotes advanced glycation end products (AGEs), which are crucial in pathogenesis of human disease. Previous studies have demonstrated that MG reacts with proteins and compositional modifications reflect loss of biological activity. The aim of the study was to investigate the effect of in vitro MG-induced glycation on human high density lipoprotein (HDL) and on the activity of the enzyme paraoxonase-1 (PON1). HDL was incubated in the absence or in the presence of MG (0.2mmol/L and 1.0mmol/L) (MG-HDL) for different times (3, 6, 24h) at 37° C. We evaluated apoprotein compositional changes, in both control and MG treated HDL, using intrinsic fluorescence of tryptophan and monitoring the decrease of free amino groups. Furthermore we evaluated fluorescent advanced glycation end products (Ex=370nm, Em=440nm) and the activity of HDL-paraoxonase. We demonstrated that human HDL is susceptible to glycation by MG (0.2mmol/L and 1mmol/L). The decrease of free amino groups and of intrinsic fluorescence of tryptophan demonstrates HDL apoprotein modifications in HDL incubated with MG. The compositional changes are associated with a significant increase in fluorescent advanced glycation end products and with a significant decrease of paraoxonase-1 enzyme activity associated with the HDL surface. HDL-associated paraoxonase is responsible for the anti-inflammatory and anti-oxidative properties of HDL and detoxification against homocysteine-thiolactone. Therefore, modifications of apoprotein composition and the decrease of paraoxonase-1 activity in MG-treated HDL could affect the protective effect exerted by HDL against oxidative damage and could contribute to complications in patients affected by diseases

  3. Beneficial Effect of Higher Dietary Fiber Intake on Plasma HDL-C and TC/HDL-C Ratio among Chinese Rural-to-Urban Migrant Workers.

    Science.gov (United States)

    Zhou, Quan; Wu, Jiang; Tang, Jie; Wang, Jia-Ji; Lu, Chu-Hong; Wang, Pei-Xi

    2015-04-29

    Research has shown that high-dose supplemental dietary fiber intake has beneficial effects on cardiovascular risk factors. To clarify such a relationship, we examined the association between daily dietary fiber intake and plasma lipids using a cross-sectional design including 1034 (M 502, F 532) rural-to-urban workers in China. We found a dose-response relationship between increased dietary fiber intakes and increase of HDL cholesterol in male workers. There was also a dose-response relationship between increased dietary fiber intake and decreased total cholesterol to HDL cholesterol (TC/HDL-C) ratio in both male and female workers, after adjusting for potential confounders (p for trend, all p dietary fiber intake increased from less than 18 g/day to over 30 g/day, the average HDL cholesterol level increased by 10.1%, and the TC/HDL-C ratio decreased by 14.4% for males (p = 0.020) and by 11.1% for females (p = 0.048). In conclusion, higher daily dietary fiber consumption is associated with beneficial effect on cholesterol for rural-to-urban workers in China, suggesting its potential beneficial effect on decreasing the risk of cardiovascular diseases.

  4. Effects of vegetarian diets on chylomicron metabolism and high density lipoprotein qualitative aspects (HDL)

    OpenAIRE

    Juliana Christiano de Matos Vinagre

    2010-01-01

    Dietas vegetarianas oferecem baixo conteúdo calórico, baixos níveis de gordura saturada, colesterol, proteína animal e mais altos de gordura polinsaturada, carboidratos, fibras, magnésio, boro, folato e antioxidantes. Todos esses nutrientes influenciam nos fatores de risco de doenças cardiovasculares como hipertensão arterial, diabetes mellitus, obesidade e dislipidemias. Níveis plasmáticos de colesterol total, colesterol de lipoproteína de baixa densidade (LDL), de lipoproteína de densidade ...

  5. HDL enhances oxidation of LDL in vitro in both men and women

    Directory of Open Access Journals (Sweden)

    Lehtimäki T

    2005-10-01

    Full Text Available Abstract Background Oxidative modification of low-density lipoprotein (LDL is a key event in the oxidation hypothesis of atherogenesis. Some in vitro experiments have previously suggested that high-density lipoprotein (HDL co-incubated with LDL prevents Cu2+-induced oxidation of LDL, while some other studies have observed an opposite effect. To comprehensively clarify the role of HDL in this context, we isolated LDL, HDL2 and HDL3 from sera of 61 free-living individuals (33 women and 28 men. Results When the isolated LDL was subjected to Cu2+-induced oxidation, both HDL2 and HDL3 particles increased the rate of appearance and the final concentration of conjugated dienes similarly in both genders. Oxidation rate was positively associated with polyunsaturated fatty acid content of the lipoproteins in that it was positively related to the content of linoleate and negatively related to oleate. More saturated fats thus protected the lipoproteins from damage. Conclusion We conclude that in vitro HDL does not protect LDL from oxidation, but is in fact oxidized fastest of all lipoproteins due to its fatty acid composition, which is oxidation promoting.

  6. [ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS].

    Science.gov (United States)

    Awad, Fernanda; Contreras-Duarte, Susana; Molina, Patricia; Quiñones, Verónica; Serrano, Valentina; Abbott, Eduardo; Maiz, Alberto; Busso, Dolores; Rigotti, Attilio

    2015-09-01

    high density lipoproteins (HDL) have important cardiovascular protective effects mediated by their role in reverse cholesterol transport as well as other functional activities, including significant anti-inflammatory and antioxidant properties. It has been shown that HDL anti-inflammatory and antioxidant functions are defective in metabolically stable diabetic patients; however they have not been evaluated during a hyperglycemic crisis. to determine the antioxidant activity of HDL during a severe diabetic decompensation and to analyze whether this function is restored after resolution of the acute event. the antioxidant activity of HDL was measured in vitro by a fluorescent assay in plasma samples obtained from diabetic patients with acute metabolic decompensation at admission, recovery within the hospital and follow-up in ambulatory care. As a comparison, HDL particles from some healthy subjects were used as controls. the HDL antioxidant function was significantly reduced in patients during an acute diabetic decompensation compared with the control group, and was gradually restored reaching normal values during the ambulatory follow-up. Hyperglycemic crisis also showed low plasma paraoxonase-1 activity, which increased significantly during at follow-up. HDL particles isolated from acute diabetic descompensated patients exhibit a significantly and reversibly low antioxidant capacity, which is probably due to a reduced paraoxonase-1 activity. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  7. Carriles para alta velocidad. Comportamiento en fatiga

    Directory of Open Access Journals (Sweden)

    Duart, J. M.

    2005-02-01

    -aire inducido. Los ensayos de fatiga de los carriles soldados se llevan a cabo por flexión en cuatro puntos en concordancia con la norma europea. El método Locati, descrito en esta nota, está basado en la Ley de Miner de daño acumulado y en las curvas de Wohler del material ensayado. Permite calcular, con precisión suficiente, las tensiones límites de fatiga al 50%. Así, los valores obtenidos, en ensayos a dos millones de ciclos, para carriles sin soldar (Sf = 353 MPa, carriles soldados con precalentamiento de oxipropano (Sf = 225 MPa y carriles soldados con precalentamiento de propano-aire inducido (Sf = 210 MPa son muy similares y aceptables a los estipulados por los métodos de determinación del límite de fatiga según norma europea. Debido a la comodidad, rapidez y bajo coste del método Locati resulta, en nuestra opinión, muy adecuado para el control de calidad de los procesos de soldadura aluminotérmica en vigor, de carriles de alta resistencia.

  8. Discordance between high non-HDL cholesterol and high LDL-cholesterol among US adults.

    Science.gov (United States)

    Kilgore, Meredith; Muntner, Paul; Woolley, J Michael; Sharma, Pradeep; Bittner, Vera; Rosenson, Robert S

    2014-01-01

    Although low-density lipoprotein cholesterol (LDL-C) is recommended as the primary marker to guide lipid-lowering therapy, some data suggest non-high-density lipoprotein cholesterol (non-HDL-C) may better reflect coronary heart disease risk. Discordance between these measures has not been evaluated. We used data from the National Health and Nutrition Examination Surveys 2005-2010 (n = 4986) to examine the discordance between these lipid parameters. Elevated levels of non-HDL-C and LDL-C were defined by using the 2004 Adult Treatment Panel III guidelines. The prevalence of high non-HDL-C and LDL-C was 22.7% and 24.5%, respectively. Of participants with high non-HDL-C, 9.7% had normal LDL-C, whereas 15.7% of participants with high LDL-C had normal non-HDL-C. We estimate 3.9 million US adults had high non-HDL-C and normal LDL-C, whereas 6.8 million US adults had high LDL-C and normal non-HDL-C. Persons with high non-HDL-C and normal LDL-C were older, more likely to be men, Hispanic, and have impaired fasting glucose, diabetes metabolic syndrome, and more risk factors for coronary heart disease. Substantial discordance exists between high non-HDL-C and high LDL-C among US adults. Reliance on either single measure could result in failure to classify cardiovascular heart disease risks appropriately. Copyright © 2014 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  9. Identification of cardiometabolic risk: visceral adiposity index versus triglyceride/HDL cholesterol ratio.

    Science.gov (United States)

    Salazar, Martin R; Carbajal, Horacio A; Espeche, Walter G; Aizpurúa, Marcelo; Maciel, Pablo M; Reaven, Gerald M

    2014-02-01

    The plasma concentration ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) can identify cardiometabolic risk and cardiovascular disease. The visceral adiposity index is a sex-specific index, in which measurements of body mass index and waist circumference are combined with TG and HDL-C concentrations. The current analysis was initiated to see if the visceral adiposity index would improve the ability of the TG/HDL-C to identify increased cardiometabolic risk and outcome. Cardiometabolic data were obtained in 2003 from 926 apparently healthy individuals, 796 of whom were evaluated in 2012 for evidence of incident cardiovascular disease. The relationship between TG/HDL-C and values for visceral adiposity index was evaluated by Pearson's correlation coefficient. The relative risks for first cardiovascular event between individuals above and below the TG/HDL-C sex-specific cut points, and in the top quartile of visceral adiposity index versus the remaining 3 quartiles, were estimated using Cox proportional hazard models. TG/HDL-C concentration and visceral adiposity index were highly correlated (r = 0.99) in both men and women. Although more men (133 vs121) and women (73 vs 59) were identified as being at "high risk" by an elevated TG/HDL-C ratio, the individual cardiometabolic risk factors were essentially identical with either index used. However, the hazard ratio of developing cardiovascular disease was significantly increased in individuals with an elevated TG/HDL-C, whereas it was not the case when the visceral adiposity index was used to define "high risk." The visceral adiposity index does not identify individuals with an adverse cardiometabolic profile any better than the TG/HDL-C. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Coenzyme O*U1*UO, Alpha-Tocopherol and Free Cholesterol in HDL and LDL Fractions

    DEFF Research Database (Denmark)

    Johansen, Kurt; Theorell, Henning; Karlsson, Jan

    1991-01-01

    Farmakologi, Alpha-tocopherol, Coenzyme Q*U1*U0, free cholesterol, LDL, Antioxidants, Lipoproteins, HDL......Farmakologi, Alpha-tocopherol, Coenzyme Q*U1*U0, free cholesterol, LDL, Antioxidants, Lipoproteins, HDL...

  11. PLTP activity in premenopausal women. Relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance.

    Science.gov (United States)

    Murdoch, S J; Carr, M C; Hokanson, J E; Brunzell, J D; Albers, J J

    2000-02-01

    Plasma phospholipid transfer protein (PLTP) is thought to play a major role in the facilitated transfer of phospholipids between lipoproteins and in the modulation of high density lipoprotein (HDL) particle size and composition. However, little has been reported concerning the relationships of PLTP with plasma lipoprotein parameters, lipolytic enzymes, body fat distribution, insulin, and glucose in normolipidemic individuals, particularly females. In the present study, 50 normolipidemic healthy premenopausal females were investigated. The relationships between the plasma PLTP activity and selected variables were assessed. PLTP activity was significantly and positively correlated with low density lipoprotein (LDL) cholesterol (r(s) = 0.53), apoB (r(s) = 0.44), glucose (r(s) = 0.40), HDL cholesterol (r(s) = 0.38), HDL(3) cholesterol (r(s) = 0.37), lipoprotein lipase activity (r(s) = 0.36), insulin (r(s) = 0.33), subcutaneous abdominal fat (r(s) = 0.36), intra-abdominal fat (r(s) = 0.29), and body mass index (r(s) = 0.29). HDL(2) cholesterol, triglyceride, and hepatic lipase were not significantly related to PLTP activity. As HDL(2) can be decreased by hepatic lipase and hepatic lipase is increased in obesity with increasing intra-abdominal fat, the participants were divided into sub-groups of non-obese (n = 35) and obese (n = 15) individuals and the correlation of PLTP with HDL(2) cholesterol was re-examined. In the non-obese subjects, HDL(2) cholesterol was found to be significantly and positively related to PLTP activity (r(s) = 0.44). Adjustment of the HDL(2) values for the effect of hepatic lipase activity resulted in a significant positive correlation between PLTP and HDL(2) (r(s) = 0.41), indicating that the strength of the relationship between PLTP activity and HDL(2) can be reduced by the opposing effect of hepatic lipase on HDL(2) concentrations. We conclude that PLTP-facilitated lipid transfer activity is related to HDL and LDL metabolism, as well as

  12. Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels

    DEFF Research Database (Denmark)

    Haase, C L; Frikke-Schmidt, R; Nordestgaard, B G

    2011-01-01

    levels. Mutations in apolipoprotein (apo) A-I, the major protein constituent of HDL, might be associated with low HDL cholesterol and predispose to IHD and early death. DESIGN: We resequenced APOA1 in 190 individuals and examined the effect of mutations on HDL cholesterol, risk of IHD, myocardial...

  13. Performances comparées du HDL-cholestérol et du ratio cholestérol ...

    African Journals Online (AJOL)

    Current definition criteria of the metabolic syndrome (MetS) do not adequately identify at risk African origin subjects. The objective was to determine which of total cholesterol/HDL-cholesterol (TC/HDL-C) and HDL-cholesterol is the best predictor of metabolic syndrome (SMet) in Benin adults. This cross-sectional study was ...

  14. Evaluation of Serum HDL and LDL levels in Type II Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    K R Joshi

    2013-06-01

    Full Text Available   Introduction: Diabetes mellitus is a type of metabolic disorder characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both. This study intended to compare High Density Lipoprotein Cholesterol (HDL and Low Density Lipoprotein Cholesterol (LDL profile between type II diabetic and non-diabetic subjects and also find the correlation between HDL and LDL cholesterol in type II diabetic.   Methods: The study was conducted on 100 total subjects out of which experimental group with 50 subjects of known Type II Diabetes mellitus and control group with 50 subjects.   Results: The result of the present study suggests that fasting blood sugar and LDL cholesterol levels were increased but HDL cholesterol level was reduced in type II diabetic subjects when compared to controls.   Conclusion: The estimation of HDL cholesterol and LDL cholesterol in type II diabetes mellitus is very useful as it may serve as a useful parameter to monitor the prognosis of the patient.

  15. SISTEMA RADICULAR DO ARROZ DE TERRAS ALTAS SOB DEFICIÊNCIA HÍDRICA UPLAND RICE ROOT SYSTEM UNDER WATER DEFICIT

    Directory of Open Access Journals (Sweden)

    Camilla Alves Pereira Rodrigues

    2011-01-01

    Full Text Available A morfologia do sistema radicular é uma das características importantes na tolerância de plantas à deficiência hídrica. Assim, objetivou-se verificar aspectos morfológicos de importância, quanto à tolerância à deficiência hídrica do sistema radicular de cultivares de arroz de terras altas, cultivadas sob deficiência hídrica, em condições de casa-de-vegetação, para discriminar linhagens para regiões com distribuição irregular de chuvas. Para tanto, foram semeadas 37 cultivares com ampla variabilidade genética, em tubos de PVC (25 cm de diâmetro e 80 cm de altura com solo, submetidas, após a emissão das panículas, a dois regimes hídricos: sem e com deficiência hídrica (reposição de, aproximadamente, 50% da água evapotranspirada. A densidade radicular foi avaliada na colheita dos grãos (de 20 cm em 20 cm, da superfície até 80 cm de profundidade, tendo as cultivares diferido quanto a esta característica. As cultivares Muruim Branco, Cano Roxo, Amarelão/Douradão e Arroz Agulhinha apresentaram alta densidade radicular, tanto sob deficiência como sob adequada disponibilidade hídrica. A densidade radicular de cultivares de arroz de terras altas, avaliada em colunas de solo, se relacionou, positivamente, com a tolerância à deficiência hídrica destas cultivares, em condições de campo. Esta metodologia constitui-se em importante ferramenta de fenotipagem, para tolerância à deficiência hídrica em arroz.

    PALAVRAS-CHAVE: Cultivares de arroz; seleção para tolerância à seca; temperatura das folhas; densidade de raízes.The root system morphology is one of the most important characteristics in the adaptation of plants to water stress. So, the objective of this study was to analyse important morphologic aspects, regarding the drought tolerance of the root system of upland rice cultivars cultivated under water stress conditions in a greenhouse, in order to discriminate lines to areas with uneven

  16. A densidade básica e característica anatômicas variam radialmente na madeira de Astronium graveolens Jacq. (Anacardiaceae. Basic density and anatomical features vary in the radial direction in the wood of Astronium graveolens Jacq. (Anacardiaceae.

    Directory of Open Access Journals (Sweden)

    Camila Moura SANTOS

    2011-12-01

    Full Text Available Estudos sobre variações nas dimensões celulares de espécies arbóreas de clima tropical são escassos. Sendo assim, o objetivo deste trabalho foi caracterizar a variação da densidade básica e da anatomia no sentido radial da madeira de Astronium graveolens Jacq. Coletaram-se cinco indivíduos da espécie, provenientes da Estação Experimental Luiz Antônio (SP. Os métodos empregados nas análises foram os usualmente utilizados em pesquisas de densidade e anatomia de madeira. De acordo com os resultados foram constatadas altas correlações entre densidade básica, comprimento de fibra, espessura da parede da fibra, diâmetro de vaso e frequência de vaso com a distância da medula. A densidade básica da madeira é altamente dependente do comprimento das fibras, espessura da parede das fibras e diâmetro dos vasos, ocorrendo aumento no sentido da medula para a casca.Studies on variations in cell sizes of tree species in tropical climate are scarce. Thus, the aim was characterize the radial variation of basic density and wood anatomy of Astronium graveolens Jacq. Five specimens were collected at the Luiz Antônio Experimental Station,(SP. Sstandard methods for studying the density and wood anatomy were employed. According to the results we observed high correlation among basic density,fiber length, fiber wall thickness, vessel diameter and vessel frequency with distance fromthe pith. The wood density is highly dependent on fiber length, fiber wall thicknessand vessel diameter, there was an increase towards the pith to bark.

  17. Structure-function relationships in reconstituted HDL: Focus on antioxidative activity and cholesterol efflux capacity.

    Science.gov (United States)

    Cukier, Alexandre M O; Therond, Patrice; Didichenko, Svetlana A; Guillas, Isabelle; Chapman, M John; Wright, Samuel D; Kontush, Anatol

    2017-09-01

    High-density lipoprotein (HDL) contains multiple components that endow it with biological activities. Apolipoprotein A-I (apoA-I) and surface phospholipids contribute to these activities; however, structure-function relationships in HDL particles remain incompletely characterised. Reconstituted HDLs (rHDLs) were prepared from apoA-I and soy phosphatidylcholine (PC) at molar ratios of 1:50, 1:100 and 1:150. Oxidative status of apoA-I was varied using controlled oxidation of Met112 residue. HDL-mediated inactivation of PC hydroperoxides (PCOOH) derived from mildly pre-oxidized low-density lipoprotein (LDL) was evaluated by HPLC with chemiluminescent detection in HDL+LDL mixtures and re-isolated LDL. Cellular cholesterol efflux was characterised in RAW264.7 macrophages. rHDL inactivated LDL-derived PCOOH in a dose- and time-dependent manner. The capacity of rHDL to both inactivate PCOOH and efflux cholesterol via ATP-binding cassette transporter A1 (ABCA1) increased with increasing apoA-I/PC ratio proportionally to the apoA-I content in rHDL. Controlled oxidation of apoA-I Met112 gradually decreased PCOOH-inactivating capacity of rHDL but increased ABCA1-mediated cellular cholesterol efflux. Increasing apoA-I content in rHDL enhanced its antioxidative activity towards oxidized LDL and cholesterol efflux capacity via ABCA1, whereas oxidation of apoA-I Met112 decreased the antioxidative activity but increased the cholesterol efflux. These findings provide important considerations in the design of future HDL therapeutics. Non-standard abbreviations and acronyms: AAPH, 2,2'-azobis(-amidinopropane) dihydrochloride; ABCA1, ATP-binding cassette transporter A1; apoA-I, apolipoprotein A-I; BHT, butylated hydroxytoluene; CV, cardiovascular; EDTA, ethylenediaminetetraacetic acid; HDL-C, high-density lipoprotein cholesterol; LOOH, lipid hydroperoxides; Met(O), methionine sulfoxide; Met112, methionine 112 residue; Met86, methionine 86 residue; oxLDL, oxidized low

  18. Dietary Almonds Increase Serum HDL Cholesterol in Coronary Artery Disease Patients in a Randomized Controlled Trial.

    Science.gov (United States)

    Jamshed, Humaira; Sultan, Fateh Ali Tipoo; Iqbal, Romaina; Gilani, Anwar Hassan

    2015-10-01

    More than one-half of coronary artery disease (CAD) patients have low HDL cholesterol despite having well-managed LDL cholesterol. Almond supplementation has not been shown to elevate circulating HDL cholesterol concentrations in clinical trials, perhaps because the baseline HDL cholesterol of trial subjects was not low. This clinical trial was designed to test the effect of almond supplementation on low HDL cholesterol in CAD patients. A total of 150 CAD patients (50 per group), with serum LDL cholesterol ≤100 mg/dL and HDL cholesterol ≤40 mg/dL in men and ≤50 mg/dL in women, were recruited from the Aga Khan University Hospital. After recording vital signs and completing a dietary and physical activity questionnaire, patients were randomly assigned to 1 of the following 3 groups: the no-intervention group (NI), the Pakistani almonds group (PA), and the American almonds group (AA). The respective almond varieties (10 g/d) were given to patients with instructions to soak them overnight, remove the skin, and eat them before breakfast. Blood samples for lipid profiling, body weight, and blood pressure were collected, and assessment of dietary patterns was done at baseline, week 6, and week 12. Almonds significantly increased HDL cholesterol. At weeks 6 and 12, HDL cholesterol was 12-14% and 14-16% higher, respectively, in the PA and AA than their respective baselines. In line with previous reports, serum concentrations of total cholesterol, triglycerides, LDL cholesterol, and VLDL cholesterol; total-to-HDL and LDL-to-HDL cholesterol ratios, and the atherogenic index were reduced in both the PA and AA at weeks 6 and 12 compared with baseline (P almond groups. Dietary patterns, body weight, and blood pressure did not change in any of the 3 groups during the trial. A low dose of almonds (10 g/d) consumed before breakfast can increase HDL cholesterol, in addition to improving other markers of abnormal lipid metabolism in CAD patients with low initial HDL cholesterol

  19. Sistema Computacional para Ajuste de Funções Densidade de Probabilidade

    Directory of Open Access Journals (Sweden)

    Daniel Henrique Breda Binoti

    Full Text Available RESUMO Este trabalho teve por objetivo iniciar, implementar e validar um projeto de construção de um sistema computadorizado para ajuste de funções densidade de probabilidade. O FitFD foi desenvolvido utilizando-se a linguagem de programação Java. Como ambiente de desenvolvimento foram utilizadas a IDE (Integrated Development Environment Netbeans 7.1 e a JDK 7.3 (Java Development Kit. Os testes do sistema foram realizados em ambiente Windows. Foram implementadas no sistema as seguintes funções densidade de probabilidade: Weibull (2P, 3P, 2P com dap mínimo como locação, 3P truncada, hiperbólica (2P, 3P, 2P com dap mínimo como locação, 3P truncada, log-logística (2P, 3P, 2P com dap mínimo como locação, logística generalizada, Fatigue life (2P e 3P e Frechet (2P e 3P. O sistema desenvolvido auxilia os usuários na definição e escolha da fdp que melhor atenda suas necessidades, contudo melhorias são necessárias. O projeto iniciado mostrou-se eficiente para ajustes de funções de densidade probabilidade.

  20. Comportamento de poedeiras criadas a diferentes densidades e tamanhos de grupo em ambiente enriquecido

    Directory of Open Access Journals (Sweden)

    Danilo Florentino Pereira

    2013-06-01

    Full Text Available O objetivo deste trabalho foi determinar diferenças comportamentais entre poedeiras criadas sob diferentes densidades e tamanhos de grupo, em condições de ambiente enriquecido. Foram utilizadas poedeiras Isa Brown com idade entre 30 e 32 semanas alojadas em galpões de escala reduzida e distorcida. As aves foram criadas durante 28 dias, em baias com cama de maravalha, poleiro e ninho. Foram avaliados dois tamanhos de grupos (6 e 12 aves e duas densidades de criação (774 e 1.440 cm² por ave, em arranjo fatorial com três repetições. Em amostras de vídeo de 15 min, foram registrados as frequências e os tempos de expressão dos comportamentos: arrumar penas, banho de areia, bater asas, beber água, bicar, coçar a cabeça, ciscar, comer, empoleirar, esticar perna, perseguir, sentar e visitar o ninho. Foram observados efeitos significativos dos tratamentos e da interação entre eles. O grupo de seis aves manifestou aumento da frequência de comportamentos que indicam maior frustração das aves, independentemente da densidade. O tamanho de grupo é o fator mais importante para o bem-estar das aves.

  1. Effect of uremia on HDL composition, vascular inflammation, and atherosclerosis in wild-type mice

    DEFF Research Database (Denmark)

    Bang, Christian A; Bro, Susanne; Bartels, Emil D

    2007-01-01

    Wild-type mice normally do not develop atherosclerosis, unless fed cholic acid. Uremia is proinflammatory and increases atherosclerosis 6- to 10-fold in apolipoprotein E-deficient mice. This study examined the effect of uremia on lipoproteins, vascular inflammation, and atherosclerosis in wild...... in cholic acid-fed sham mice. The results suggest that moderate uremia neither induces aortic inflammation nor atherosclerosis in C57BL/6J mice despite increased LDL/HDL cholesterol ratio and altered HDL composition....

  2. Relationship TG/HDL-C and insulin resistance in adult women by nutritional status

    Directory of Open Access Journals (Sweden)

    Lorena Belén

    2014-04-01

    Full Text Available Introduction: The ratio assessment TG/HDL-C is an indicator of LDL size, facilitating the detection of individuals with increased atherogenic risk. Estimating the size of the LDL becomes important, especially in patients with TG values near the upper limit of normal values of reference and HDL-C. The objective of the study is to estimate the association between TG/HDL-C and insulin resistance (IR by nutritional status in adult women attending the Foundation for Endocrine Metabolic Diseases Research and Applied Clinical Research (FIEEM.Material and methods: Design Cross-sectional, non-pregnant adult women, apparently healthy, older than 30 years old, attending FIEEM in the Autonomous City of Buenos Aires. Dependent variable: TG/HDL-C ≥ 3.0 considered high value. Independent variables: IR by homeostatic model index HOMA-IR ≥ 2.5 categorizing the sample into two groups: with and without IR, and controlled by nutritional status using body mass index (BMI and waist circumference (CC. SPSS Statistics 15.0, calculating X2 or Fisher exact test, OR with confidence intervals of 95% and establishing logistic regression p value < 0.05.Results: We evaluated a purposive sample of 104 women (31.4% and 26% IR with TG/HDL-C high. 84.6% were overweight or obese and 88.5% increased CC. Women with BMI had significantly increased 0.15-fold increased risk (95% CI = 0.01 to 1.26 for TG/HDL-C high (p = 0.04 than the control women. There was no significance with increased CC. The ratio TG/HDL-C high IR was significantly correlated (r = 0.30 p = 0.002.Conclusions: Body weight was significantly associated with IR and the ratio TG/HDL-C increased. This ratio correlated significantly with IR in apparently healthy women.

  3. Relations between particle size of HDL and LDL lipoproteins and cholesterol esterification rate

    Czech Academy of Sciences Publication Activity Database

    Dobiášová, Milada; Urbanová, Z.; Šamánek, M.

    2005-01-01

    Roč. 54, č. 2 (2005), s. 159-165 ISSN 0862-8408 R&D Projects: GA MZd(CZ) NA6590; GA MZd(CZ) NR8328 Institutional research plan: CEZ:AV0Z5011922 Keywords : particle size of lipoproteins * FER(HDL) * Log(TG/HDL-C) Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 1.806, year: 2005

  4. Association between triglyceride/HDL cholesterol ratio and carotid atherosclerosis in postmenopausal middle-aged women.

    Science.gov (United States)

    Masson, Walter; Siniawski, Daniel; Lobo, Martín; Molinero, Graciela; Huerín, Melina

    2016-01-01

    The triglyceride/HDL cholesterol ratio, as a surrogate marker of insulin resistance, may be associated to presence of subclinical carotid atherosclerosis in postmenopausal women. The aim of this study was to explore this association. Women (last menstrual period≥2 years) in primary prevention up to 65 years of age were recruited. Association between the triglyceride/HDL cholesterol (HDL-C) ratio and presence of carotid plaque, assessed by ultrasonography, was analyzed. ROC analysis was performed, determining the precision of this ratio to detect carotid plaque. A total of 332 women (age 57±5 years) were recruited. Triglyceride/HDL-C ratio was 2.35±1.6. Prevalence of carotid plaque was 29%. Women with carotid plaque had higher triglyceride/HDL-C ratios (3.33±1.96 vs. 2.1±1.2, P<.001) than women with no carotid plaque. A positive relationship was seen between quintiles of this ratio and prevalence of carotid plaque (p<.001). Regardless of other risk factors, women with higher triglyceride/HDL-C ratios were more likely to have carotid plaque (odds ratio 1.47, 95% confidence interval 1.20-1.79, P<.001). The area under the curve of the triglyceride/HDL-C ratio to detect carotid plaque was .71 (95% confidence interval .65 to .76), and the optimal cut-off point was 2.04. In postmenopausal women in primary prevention, insulin resistance, estimated from the triglyceride/HDL-C ratio, was independently associated to a greater probability of carotid plaque. A value of such ratio greater than 2 may be used for assessing cardiovascular risk in this particular group of women. Copyright © 2016 SEEN. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. Original Paper Performances comparées du HDL-cholestérol et du ...

    African Journals Online (AJOL)

    CT/HDL-C) et du HDL-Cholestérol est le meilleur prédicteur du SMet chez les adultes béninois. .... (Canada) et du. Ministère de la Santé du Bénin. Le consentement éclairé écrit a été obtenu de chaque participant avant leur recrutement dans.

  6. How much does HDL cholesterol add to risk estimation? A report from the SCORE Investigators.

    LENUS (Irish Health Repository)

    Cooney, Marie Therese

    2009-06-01

    Systematic COronary Risk Evaluation (SCORE), the risk estimation system recommended by the European guidelines on cardiovascular disease prevention, estimates 10-year risk of cardiovascular disease mortality based on age, sex, country of origin, systolic blood pressure, smoking status and either total cholesterol (TC) or TC\\/high-density lipoprotein cholesterol (HDL-C) ratio. As, counterintuitively, these two systems perform very similarly, we have investigated whether incorporating HDL-C and TC as separate variables improves risk estimation.

  7. High plasma HDL-C attenuates stress hyperglycemia during acute phase of myocardial infarction.

    Science.gov (United States)

    Carvalho, Luiz Sergio F; Cintra, Riobaldo M R; Moura, Filipe A; Martins, Naiara V G; Quinaglia E Silva, Jose C; Coelho, Otavio R; Sposito, Andrei C

    2012-01-01

    During myocardial infarction (MI), a transient decrease of both insulin sensitivity and secretion triggers stress hyperglycemia, which is followed by a substantial increase in mortality. Recent findings in cellular models indicate that HDL may act on glucose homeostasis by improving insulin sensitivity and secretion. In this study, we explored this potential effect in patients during the acute phase of MI. Plasma glucose, insulin and C-peptide were measured at admission in the first 24h and on the fifth day after MI with ST-segment elevation in 183 consecutive non-diabetic patients. Patients were divided into HDL-C quartiles for the analyses (Q1: 47mg/dL). The Homeostasis Model Assessment version 2 was used to assess insulin sensitivity (HOMA2S) and beta-cell function (HOMA2B). On admission, no difference was found between the quartiles in glucose (p=0.6), insulin (p=0.6) or C-peptide (p=0.5) levels, HOMA2S (p=0.9) or HOMA2B (p=1.0). On the fifth day there was a reduction in glucose levels whose intensity was directly proportional to the HDL-C quartile (p<0.001). At the same time, there was a reduction in plasma insulin (p<0.001) and C-peptides (p<0.001) whose magnitude was inversely proportional to the HDL-C quartile. Consistently, the increase of HOMA2S (p<0.001) and HOMA2B (p=0.01) were also positively associated with HDL-C levels. Furthermore, plasma HDL-C levels were inversely and independently associated with blood glucose change during the acute phase. This study demonstrates the association between low plasma HDL-C levels and increased duration of stress hyperglycemia during MI and suggests in humans the interaction between HDL and insulin secretion and sensitivity. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  8. Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

    Science.gov (United States)

    Zagayko, Andriy L.; Kravchenko, Ganna B.; Krasilnikova, Oksana A.; Ogai, Yuri O.

    2013-01-01

    HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from “Enoant” obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG) levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON) and lecithin:cholesterol acyltransferase (LCAT) activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP) activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After “Enoant” administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats. PMID:23936611

  9. Grape polyphenols increase the activity of HDL enzymes in old and obese rats.

    Science.gov (United States)

    Zagayko, Andriy L; Kravchenko, Ganna B; Krasilnikova, Oksana A; Ogai, Yuri O

    2013-01-01

    HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from "Enoant" obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG) levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON) and lecithin:cholesterol acyltransferase (LCAT) activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP) activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After "Enoant" administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats.

  10. Therapeutic targets to raise HDL in patients at risk or with coronary artery disease.

    Science.gov (United States)

    Lüscher, Thomas F; von Eckardstein, Arnold; Simic, Branko

    2012-11-01

    The plasma levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Traditional HDL-raising therapies, like fibrates, PPAR-γ agonists, and nicacin, among others, are associated with undesirable side effects, limited efficacy, or have not yet been shown to improve morbidity and mortality on top of statins in clinical outcome trials. A novel pharmacological target for raising circulating HDL-C levels is the cholesterol ester transfer protein (CETP), an enzyme that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. Four pharmacological small-molecule inhibitors of CETP, i.e. torcetrapib (Pfizer), dalcetrapib (JTT-705; Roche), anacetrapib (Merck), and evacetrapib (Eli Lilly) have been developed. Notwithstanding a marked increase in HDL, torcetrapib was associated with an increase in all-cause mortality in the ILLUMINATE trial and raised safety concerns related to the off-target effects of CETP inhibition. Most recently, development of dalcetrapib was abruptly stopped due to a lack of clinically meaningful efficacy. Thus, it will be of utmost importance to demonstrate that the remaining CETP inhibitors in development not only increase HDL-C levels in plasma, but also improve HDL-function in patients with coronary disease or an acute coronary syndrome.

  11. Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events

    International Nuclear Information System (INIS)

    Cho, Sung Woo; Kim, Byung Gyu; Kim, Byung Ok; Byun, Young Sup; Goh, Choong Won; Rhee, Kun Joo; Kwon, Hyuck Moon; Lee, Byoung Kwon

    2016-01-01

    Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients

  12. Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Sung Woo [Division of Cardiology - Department of Internal Medicine - Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Division of Cardiology - Department of Medicine - Samsung Medical Center, Seoul (Korea, Republic of); Kim, Byung Gyu; Kim, Byung Ok; Byun, Young Sup; Goh, Choong Won; Rhee, Kun Joo [Division of Cardiology - Department of Internal Medicine - Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Kwon, Hyuck Moon; Lee, Byoung Kwon, E-mail: cardiobk@yuhs.ac [Division of Cardiology - Department of Internal Medicine - Gangnam Severance Hospital - Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2016-01-15

    Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients.

  13. Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

    Directory of Open Access Journals (Sweden)

    Andriy L. Zagayko

    2013-01-01

    Full Text Available HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from “Enoant” obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON and lecithin:cholesterol acyltransferase (LCAT activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After “Enoant” administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats.

  14. Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects

    DEFF Research Database (Denmark)

    Plomgaard, P; Dullaart, R P F; de Vries, R

    2009-01-01

    protein (PLTP) activity and the ability of plasma to promote cholesterol efflux from cultured fibroblasts. RESULTS: ApoM was approximately 9% lower in patients with type 2 diabetes compared to controls (0.025 +/- 0.006 vs. 0.027 +/- 0.007 g L(-1), P = 0.01). The difference in apoM was largely attributable...... diabetes. Pre-beta-HDL and pre-beta-HDL formation are positively associated with apoM, supporting the hypothesis that apoM plays a role in HDL remodelling in humans. Lower apoM may provide a mechanism to explain why pre-beta-HDL formation is not increased in type 2 diabetes despite elevated PLTP activity.......OBJECTIVE: Studies in mice suggest that plasma apoM is lowered in hyperinsulinaemic diabetes and that apoM stimulates formation of pre-beta-HDL. Pre-beta-HDL is an acceptor of cellular cholesterol and may be critical for reverse cholesterol transport. Herein, we examined whether patients with type...

  15. BRSMG Caravera: cultivar de arroz para terras altas

    OpenAIRE

    Soares,Antônio Alves; Reis,Moizés de Sousa; Cornélio,Vanda Maria de Oliveira; Soares,Plínio César; Costa Júnior,Geovane Tadeu; Guedes,Janine Magalhães; Leite,Natália Alves; Souza,Moacil Alves de; Dias,Fábio Pereira

    2008-01-01

    Foi disponibilizada a cultivar BRSMG Caravera, de arroz de terras altas, para o cultivo em Minas Gerais. A cultivar possui arquitetura moderna, resistência ao acamamento, ciclo de maturação de 113 dias, moderada resistência às principais doenças, à exceção da brusone-da-panícula, à qual é moderadamente suscetível, alto potencial produtivo, grão tipo longo-fino de alta qualidade culinária.

  16. High intensity Discharge lighting; Alumbrado de alta intensidad de descarga

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza E, Ernesto J. [Manufacturera de Reactores, S. A., Mexico, D. F. (Mexico)

    1993-12-31

    This paper gets into contact with some fundamentals in the operation of high discharge intensity lamps. There are useful definitions, as well as the study of the operation of high pressure sodium lamps and of metallic additives operating at less than nominal power. [Espanol] Este trabajo pone al lector en contacto con algunos fundamentos de la operacion de las lamparas de alta intensidad de descarga (HID). Se encuentra con definiciones utiles, asi como el estudio de la operacion de las lamparas de sodio en alta presion y de aditivos metalicos operando a una potencia menor que la nominal.

  17. High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease

    Directory of Open Access Journals (Sweden)

    Protasio Lemos da Luz

    2008-01-01

    Full Text Available An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c indicates an atherogenic lipid profile and a risk for the development of coronary disease. OBJECTIVE: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease. METHODS: High-risk patients (n = 374 submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index. RESULTS: The subjects consisted of 220 males and 154 females, age 57.2 ± 11.1 years, with total cholesterol of 210± 50.3 mg/dL, triglycerides of 173.8 ± 169.8 mg/dL, HDL-cholesterol (HDL-c of 40.1 ± 12.8 mg/dL, LDL-cholesterol (LDL-c of 137.3 ± 46.2 mg/dL, TG/HDL-c of 5.1 ± 5.3, and a Friesinger index of 6.6 ± 4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31-3.1; p = 0.0018; HDL-c, odds ratio of 2.21 (1.42-3.43; p = 0.0005; and TG/HDL-c, odds ratio of 2.01(1.30-3.09; p = 0.0018. However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p = 0.33] or LDL-c [1.47 (0.96-2.25; p = 0.0842]. The chi-square for linear trends for Friesinger > 4 and lipid quartiles was statistically significant for triglycerides (p = 0.0017, HDL-c (p = 0.0001, and TG/HDL-c (p = 0.0018, but not for total cholesterol (p = 0.393 or LDL-c (p = 0.0568. The multivariate analysis by logistic regression OR gave 1.3 ± 0.79 (p = .0001 for TG/HDL-c, 0.779 ± 0.074 (p = .0001 for HDL-c, and 1.234 ± 0.097 (p = 0.03 for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease. CONCLUSIONS: Although some lipid variables were associated with the extent of

  18. Metodologia para estudo do volume e densidade absoluta da placenta humana de termo

    Directory of Open Access Journals (Sweden)

    Del Nero Ulisses

    2002-01-01

    Full Text Available OBJETIVO: comparar duas metodologias para o cálculo do volume placentário em gestações normais de termo: a do princípio de Arquimedes e a do volume do cilindro, para estimar a densidade absoluta da placenta. Definir a metodologia mais adequada para o cálculo do volume e densidade placentários, que se relacione com o peso e classificação do recém-nascido. MÉTODOS: foram estudadas 50 placentas provenientes de gestações de termo sem complicações e calculados o volume e a densidade absoluta placentários: a pelo princípio de Arquimedes e b na suposição de que a placenta seria uma secção de cilindro com duas alturas diferentes do bolo placentário: com a altura média e com a altura da média aritmética do centro e extremidades. As densidades absolutas placentárias foram calculadas pelo quociente entre o peso ao ar da placenta e os diferentes volumes. RESULTADOS: a maioria das gestantes eram multíparas, idade média de 25,4 anos, volume placentário médio entre 547,8 e 610 cmsuperscript three e densidade média entre 0,94 e 1,14 g/cmsuperscript three, dependendo da metodologia empregada. CONCLUSÕES: a metodologia mais adequada para estimar o volume placentário no termo foi a do princípio de Arquimedes, pela melhor correlação com o peso dos recém-nascidos, o índice placentário e a classificação do peso dos recém-nascidos em relação à idade gestacional.

  19. Egg consumption modulates HDL lipid composition and increases the cholesterol-accepting capacity of serum in metabolic syndrome.

    Science.gov (United States)

    Andersen, Catherine J; Blesso, Christopher N; Lee, Jiyoung; Barona, Jacqueline; Shah, Dharika; Thomas, Michael J; Fernandez, Maria Luz

    2013-06-01

    We recently demonstrated that daily whole egg consumption during moderate carbohydrate restriction leads to greater increases in plasma HDL-cholesterol (HDL-C) and improvements in HDL profiles in metabolic syndrome (MetS) when compared to intake of a yolk-free egg substitute. We further investigated the effects of this intervention on HDL composition and function, hypothesizing that the phospholipid species present in egg yolk modulate HDL lipid composition to increase the cholesterol-accepting capacity of subject serum. Men and women classified with MetS were randomly assigned to consume either three whole eggs (EGG, n = 20) per day or the equivalent amount of egg substitute (SUB, n = 17) throughout a 12-week moderate carbohydrate-restricted (25-30 % of energy) diet. Relative to other HDL lipids, HDL-cholesteryl ester content increased in all subjects, with greater increases in the SUB group. Further, HDL-triacylglycerol content was reduced in EGG group subjects with normal baseline plasma HDL-C, resulting in increases in HDL-CE/TAG ratios in both groups. Phospholipid analysis by mass spectrometry revealed that HDL became enriched in phosphatidylethanolamine in the EGG group, and that EGG group HDL better reflected sphingomyelin species present in the whole egg product at week 12 compared to baseline. Further, macrophage cholesterol efflux to EGG subject serum increased from baseline to week 12, whereas no changes were observed in the SUB group. Together, these findings suggest that daily egg consumption promotes favorable shifts in HDL lipid composition and function beyond increasing plasma HDL-C in MetS.

  20. TransAlta commissions big new coal dragline

    Energy Technology Data Exchange (ETDEWEB)

    1984-10-15

    With the commissioning of one of the largest walking draglines in Canadian mining operations, TransAlta Utilities Corp. is improving the economics of its Highvale mine on the shore of Wabamun Lake, Alberta. The new Marion 8750 and its operations are outlined.

  1. Low HDL cholesterol is correlated to the acute ischemic stroke with diabetes mellitus.

    Science.gov (United States)

    Luo, Yun; Li, Jingwei; Zhang, Junfeng; Xu, Yun

    2014-11-14

    To clarify the role of lipid composition in the occurrence of acute ischemic stroke (AIS) with diabetes mellitus (DM) and its influence factors. Data was collected from the patients hospitalization in Affiliated Drum Tower Hospital of Nanjing University Medical School from October 2008 to May 2012, which included AIS and non-AIS consist of transient ischemic attack (TIA) and Vertigo or dizzy. Lipid and other risk factors including blood glucose (BG), uric acid (UA), hypertension, DM and atrial fibrillation (AF) were investigated in relation to occurrence of AIS. The level of high density lipoprotein (HDL) cholesterol was decreased obviously in the DM group compared to the non-DM group and low level of HDL cholesterol was prevalent in the AIS patients with DM. logistic regression demonstrated that decreased HDL cholesterol was correlated to the AIS with DM, not all AIS, and the relative risk of ischemic stroke in low HDL cholesterol level group was 2.113 (95% CI = 1.191-3.749, P = 0.011) compared to the high level group. Furthermore, age has the obviously impact on it. HDL cholesterol was correlated to the AIS with DM just in the populations of aged ≦70 years (OR = 0.192, P = 0.000), low level of HDL cholesterol had more high risk of ischemic stroke than that in the high level group (OR = 6.818, P = 0.002). Decreased HDL cholesterol was correlated to the occurrence of AIS with DM, especially in the populations of aged ≦70 years.

  2. Characterization of immortalized human dermal microvascular endothelial cells (HMEC-1) for the study of HDL functionality.

    Science.gov (United States)

    Muñoz-Vega, Mónica; Massó, Felipe; Páez, Araceli; Carreón-Torres, Elizabeth; Cabrera-Fuentes, Hector A; Fragoso, José Manuel; Pérez-Hernández, Nonanzit; Martinez, Laurent O; Najib, Souad; Vargas-Alarcón, Gilberto; Pérez-Méndez, Óscar

    2018-03-09

    Primary cultures endothelial cells have been used as models of endothelial related diseases such atherosclerosis. Biological behavior of primary cultures is donor-dependent and data could not be easily reproducible; endothelial cell lines are emerging options, particularly, human dermal microvascular endothelial cells (HMEC-1), that should be validated to substitute primary cultures for the study of HDL functions. Morphology, size and granularity of cells were assessed by phase contrast microscopy and flow cytometry of HMEC-1. The adhesion molecules, ICAM-1and VCAM-1 after TNF-α stimulation, and endothelial markers CD105 endoglin, as well as HDL receptor SR-BI were determined by flow cytometry. Internalization of HDL protein was demonstrated by confocal microscopy using HDL labeled with Alexa Fluor 488. HUVECs were used as reference to compared the characteristics with HMEC-1. HMEC-1 and HUVEC had similar morphologies, size and granularity. HMEC-1 expressed endothelial markers as HUVECs, as well as functional SR-B1 receptor since the cell line was able to internalize HDL particles. HMEC-1 effectively increased ICAM-1 and VCAM-1 expression after TNF-α stimulation. HUVECs showed more sensibility to TNF-α stimulus but the range of ICAM-1 and VCAM-1 expression was less homogeneous than in HMEC-1, probably due to biological variation of the former. Finally, the expression of adhesion molecules in HMEC-1 was attenuated by co-incubation with HDL. HMEC-1 possess characteristics of endothelial cells, similar to HUVECs, being a cell line suitable to evaluate the functionality of HDL vis-à-vis the endothelium.

  3. Differences in the triglyceride to HDL-cholesterol ratio between Palestinian and Israeli adults.

    Directory of Open Access Journals (Sweden)

    Ram Weiss

    Full Text Available AIMS: To evaluate differences in the triglyceride to HDL-cholesterol ratio (TG/HDL, thought to be a proxy measure of insulin resistance, between Palestinian and Israeli adults in view of the greater incidence of coronary heart disease and high prevalence of diabetes in Palestinian Arabs. RESEARCH METHODS: A population-based observational prevalence study of cardiovascular and diabetes risk factors in Jerusalem. Participants (968 Palestinians, 707 Israelis, sampled at ages 25-74 years underwent fasting and 2 h post-75 g oral challenge plasma glucose determinations. Metabolic risk was assessed using the surrogate index TG/HDL. Sex-specific comparisons were stratified by categories of body mass index and sex-specific waist circumference quartiles, adjusted by regression for age, glucose tolerance status and use of statins. RESULTS: Prevalence of overweight and obesity was substantially larger in Palestinians (p = 0.005. Prevalence of diabetes was 2.4 and 4 fold higher among Palestinian men and women, respectively (p<0.001. Adjusted TG/HDL was higher in Palestinians than Israelis across BMI and waist circumference categories (p<0.001 for both. Higher TG/HDL in Palestinians persisted in analyses restricted to participants with normal glucose tolerance and off statins. Notably, higher TG/HDL among Palestinians prevailed at a young age (25-44 years and in normal weight individuals of both sexes. CONCLUSIONS: Palestinians have a higher TG/HDL ratio than Israelis. Notably, this is evident also in young, healthy and normal weight participants. These findings indicate the need to study the determinants of this biomarker and other measures of insulin resistance in urban Arab populations and to focus research attention on earlier ages: childhood and prenatal stages of development.

  4. Criatividade e altas habilidades/superdotação

    Directory of Open Access Journals (Sweden)

    Denise de Souza Fleith

    2011-11-01

    Full Text Available Identificar e estimular a criança com altas habilidades/superdotação tem se constituído em um desafio para educadores e psicólogos. Muitas concepções acerca do fenômeno das altas habilidades têm sido propostas por estudiosos desde o início do século XX. Uma das concepções mais conhecidas sobre o superdotado é de que seria aquele indivíduo que se sai bem nos testes de inteligência, ou que apresenta um desempenho intelectual superior. Entretanto, superdotação não pode ser considerada exclusivamente como sinônimo de QI alto. Concepções atuais sobre este fenômeno têm chamado a atenção para a importância de se considerar outros aspectos como influência do ambiente, sorte, autoconceito positivo, motivação e, especialmente, a criatividade. Dois importantes objetivos da educação do aluno com altas habilidades/superdotação são: (a desenvolver talentos e habilidades, auxiliando estes indivíduos a atualizarem seu potencial e se tornarem criativos, e (b habilitá-los a darem contribuições criativas à sociedade. O objetivo deste artigo é, portanto, discutir a importância da criatividade no desenvolvimento de altas habilidades/superdotação. Palavras-chave: Superdotação. Altas Habilidades. Criatividade. Inteligência.

  5. Rendimiento de plantas de tomate injertadas y efecto de la densidad de tallos en el sistema hidropónico Yield of tomato crop as a result of grafting and shoot density in hydroponic system

    Directory of Open Access Journals (Sweden)

    Roberta M.N. Peil

    2004-06-01

    Full Text Available El cultivo de tomate en primavera con baja densidad inicial de plantas y luego aumentar-se la densidad efectiva mediante el desarrollo de tallos laterales, cuando las integrales diarias de radiación son altas, parece ser una manera prometedora de incrementar el número de frutos m-2 y uniformizar el tamaño del fruto; y presenta la ventaja adicional de requerir-se un menor número de plantas para la superficie de cultivo. Por lo tanto, se ha llevado a cabo un ensayo cuyo objetivo ha sido evaluar los efectos de la densidad de tallos sobre el rendimiento y la uniformidad de los frutos de un cultivo de tomate injertado y no injertado. El cultivo se realizó de marzo a julio de 1998, en las condiciones de invernadero en Almería (sudeste español. La densidad inicial de plantación fue de 2,4 y 3,0 plantas m-2, en el caso de las plantas no injertadas, que presentaban un único tallo en el transplante; y 1,2 plantas m-2 en las plantas injertadas, que tenían dos tallos (2,4 tallos m-2. A partir del mes de abril, mediante el desarrollo de tallos laterales (cuando el tratamiento así lo exigía se pasó a tener las siguientes densidades: 2,4; 3,0 y 3,5 tallos m-2 (plantas injertadas y no injertadas; y 3,0 plantas no injertadas m-2 a un tallo durante todo el ciclo. Los resultados muestran que plantas de tomate injertadas y transplantadas a dos tallos tuvieron igual producción total, pero frutos de tamaño más uniforme, que plantas no injertadas transplantadas a un tallo y con doble densidad de plantas. Dentro del rango de 2,4 a 3,5 tallos m-2, una mayor densidad de tallos aumentó la producción precoz y dio un tamaño más uniforme de frutos, no afectando su peso promedio y la producción total. La adición de tallos laterales (3,0 tallos m-2 supuso una reducción de un 20% en el rendimiento total, pero vino acompañada por un ahorro de un 21% y de un 39% en el número de plantas no injertadas e injertadas, respectivamente, necesarias para la misma

  6. Potato crop growth as affected by nitrogen and plant density Crescimento da batateira influenciado por nitrogênio e densidade de plantio

    Directory of Open Access Journals (Sweden)

    CARLOS ALBERTO DA SILVA OLIVEIRA

    2000-05-01

    apresentou a tendência de ficar constante nos níveis mais alto e mais baixo de nitrogênio, 70 dias após o plantio. A massa de caule específica, definida como massa por unidade de comprimento de caule, foi estabelecida como uma estimativa da espessura e capacidade de suporte do caule. A massa de folha específica, por posição na planta, foi maior nas folhas mais altas do caule, aumentou com a densidade de plantio, e não variou acentuadamente com o tempo durante o ciclo da cultura. A taxa de surgimento de folhas aumentou acentuadamente, em virtude da maior formação de ramos, causada pelo alto nível de nitrogênio, aumentando a matéria seca acima do solo, por planta. O crescimento e desenvolvimento da parte aérea da planta influenciou os componentes de produção dos tubérculos. O número de tubérculos ativos por haste diminuiu depois de 60 dias após o plantio, o que mostra que a tuberização é reversível. Funções de crescimento de tubérculos foram ajustadas, permitindo estimar coeficientes de partição de biomassa seca de cada parte da planta.

  7. Triglycerides-to-HDL ratio as a new marker of endothelial dysfunction in obese prepubertal children.

    Science.gov (United States)

    de Giorgis, Tommaso; Marcovecchio, M Loredana; Di Giovanni, Ilaria; Giannini, Cosimo; Chiavaroli, Valentina; Chiarelli, Francesco; Mohn, Angelika

    2014-02-01

    To investigate whether there is an association of the triglyceride-to-HDL cholesterol (TG:HDL-C) ratio with cardiovascular risk factors and early signs of vascular damage in obese prepubertal children. In 50 obese (27 boys, 7.8±1.4 years) and 37 normal-weight (20 boys; 7.3±1.5 years) prepubertal children, anthropometric measurements, oxidative stress markers (urinary isoprostanes (PGF2α (prostaglandin F2α)), soluble receptor for advanced glycation end-products (sRAGE)) and insulin sensitivity (homeostasis model assessment of insulin resistance (HOMA-IR) and whole-body insulin sensitivity index (WBISI)) were evaluated. Lipids profile was assessed and the TG:HDL-C ratio was calculated. In addition, high-resolution ultrasound was performed to assess carotid intima-media thickness (cIMT). Obese children showed significantly higher values of the TG:HDL-C ratio (1.9±1.1 vs 1.2±0.6, P=0.002) compared with controls. After dividing the population in tertiles of the TG:HDL-C ratio (1.67), cIMT (P=0.0003), and HOMA-IR (P=0.0001) progressively increased from the lower to the upper tertile, whereas WBISI (P=0.0003) and sRAGE (P=0.05) progressively decreased. In a regression model, the TG:HDL ratio was significantly and positively associated with cIMT (r=0.493; P=0.0005). A cutoff point for TG:HDL-C ratio of 1.12 had 81% sensitivity and 49% specificity in the identification of children with cIMT values in the upper quartile (Area under the curve values from receiver operating characteristic curves=0.633±0.065, P=0.045). This study confirms the reliability of the TG:HDL-C ratio as a useful marker of cardiovascular risk. Interestingly, our results underline that the TG:HDL-C ratio is directly related with early signs of vascular damage already present in prepubertal children.

  8. Low serum hdl-c levels: a hidden threat to patients with spinal cord injury

    International Nuclear Information System (INIS)

    Ali, S.; Ayyub, A.

    2014-01-01

    To determine the serum lipid profile in patients with traumatic spinal cord injury (SCI) of duration >1 year and to compare the serum HDL-c levels of SCI patients undergoing regular physiotherapy for >60 minutes daily with those who did not Undergo physiotherapy. Study Design: Cross-sectional, comparative study. Place and Duration of Study: Spinal Cord Injury Department, AFIRM Rawalpindi and Department of Chemical Pathology, Army Medical College, Rawalpindi, from January 2013 to June 2013. Patients and Methods: Forty six patients suffering from traumatic spinal cord injury (SCI) were included. After recording the detailed medical history, fasting blood samples were obtained and analyzed for serum lipid profile. Dyslipidemias were assessed using guidelines from the National Cholesterol Education Project Adult Treatment Panel III (ATP III). Serum high-density lipoprotein cholesterol (HDL-c)< 0.9 mmol/l (40mg/dl) was considered as low HDL-c level. Results: Out of total 46 patients, 33 (71.7%) were male and 13 (28.3%) were females with mean age of 34.9+- 9.55 years. Low levels of serum HDL-c were found in 21 (45.7%) SCI patients (mean serum HDL-clevels: 0.97+-0.23). SCI patients were further categorized in two groups depending upon the status of regular physiotherapy. Statistically significant difference was found in mean serum HDL-c levels of 22 (47.82%) SCI patients undergoing regular physiotherapy as compared to 24 (52.18%) SCI patients who did not underwent physiotherapy (p<0.05). Conclusion: Patients with SCI have decreased levels of serum HDL-c, imparting an increased risk of cardiovascular disease (CVD) in these disabled persons. SCI individuals following regular physiotherapy, have better serum HDL-c levels as compared to bed-ridden SCI patients, suggesting the physical activity as an important factor to elevate the serum HDL-c in such patients. Knowledge of relative risk of CVD in persons with SCI is important for appropriate intervention alstrategies

  9. Effects of Carbohydrate and Dietary Fiber Intake, Glycemic Index and Glycemic Load on HDL Metabolism in Asian Populations.

    Science.gov (United States)

    Yanai, Hidekatsu; Katsuyama, Hisayuki; Hamasaki, Hidetaka; Abe, Shinichi; Tada, Norio; Sako, Akahito

    2014-10-01

    High-density lipoprotein (HDL) is a lipoprotein which has anti-atherogenic property by reverse cholesterol transport from the peripheral tissues to liver. Low HDL-cholesterol (HDL-C) levels are associated with the development of coronary artery diseases (CADs). Various epidemiological studies have suggested that the development of CAD increase in individuals with less than 40 mg/dL of HDL-C. In spite of accumulation of evidences which suggest a significant association between low HDL-C and cardiovascular diseases, effects of dietary factors on HDL metabolism remained largely unknown. There may be interracial differences in effects of dietary factors on HDL metabolism. Here we reviewed published articles about effects of carbohydrate and dietary fiber intake, glycemic index (GI) and glycemic load (GL), on HDL-C metabolism, regarding meta-analyses and clinical studies performed in Asian population as important articles. Low carbohydrate intake, GI and GL may be beneficially associated with HDL metabolism. Dietary fiber intake may be favorably associated with HDL metabolism in Asian populations.

  10. The LDL-HDL profile determines the risk of atherosclerosis: a mathematical model.

    Directory of Open Access Journals (Sweden)

    Wenrui Hao

    Full Text Available Atherosclerosis, the leading death in the United State, is a disease in which a plaque builds up inside the arteries. As the plaque continues to grow, the shear force of the blood flow through the decreasing cross section of the lumen increases. This force may eventually cause rupture of the plaque, resulting in the formation of thrombus, and possibly heart attack. It has long been recognized that the formation of a plaque relates to the cholesterol concentration in the blood. For example, individuals with LDL above 190 mg/dL and HDL below 40 mg/dL are at high risk, while individuals with LDL below 100 mg/dL and HDL above 50 mg/dL are at no risk. In this paper, we developed a mathematical model of the formation of a plaque, which includes the following key variables: LDL and HDL, free radicals and oxidized LDL, MMP and TIMP, cytockines: MCP-1, IFN-γ, IL-12 and PDGF, and cells: macrophages, foam cells, T cells and smooth muscle cells. The model is given by a system of partial differential equations with in evolving plaque. Simulations of the model show how the combination of the concentrations of LDL and HDL in the blood determine whether a plaque will grow or disappear. More precisely, we create a map, showing the risk of plaque development for any pair of values (LDL,HDL.

  11. A high-throughput screen for endothelial lipase using HDL as substrate.

    Science.gov (United States)

    Keller, Paul M; Rust, Timothy; Murphy, Dennis J; Matico, Rosalie; Trill, John J; Krawiec, John A; Jurewicz, Anthony; Jaye, Michael; Harpel, Mark; Thrall, Sara; Schwartz, Benjamin

    2008-07-01

    Endothelial lipase (EL) is a 482-amino-acid protein from the triglyceride lipase gene family that uses a Ser-His-Asp triad for catalysis. Its expression in endothelial cells and preference for phospholipids rather than triglycerides are unique. Animal models in which it is overexpressed or knocked out indicate EL levels are inversely correlated with high-density lipoprotein cholesterol (HDL-C). HDL-C is commonly referred to as the good form of cholesterol because it is involved in the reverse cholesterol transport pathway, in which excess cholesterol is effluxed from peripheral tissues for excretion or reabsorption. Thus, EL inhibition in humans is expected to lead to increases in HDL levels and possibly a decrease in cardiovascular disease. To discover inhibitors of EL, a coupled assay for EL has been developed, using its native substrate, HDL. Hydrolysis of HDL by EL yields free fatty acids, which are coupled through acyl-CoA synthetase, acyl-CoA oxidase, and horseradish peroxidase to produce the fluorescent species resorufin. This assay was developed into a 5-microL, 1536-well assay format, and a high-throughput screen was executed against the GSK collection. In addition to describing the screening results, novel post-HTS mechanism-of-action studies were developed for EL and applied to 1 of the screening hits as an example.

  12. A high throughput biochemical fluorometric method for measuring lipid peroxidation in HDL.

    Directory of Open Access Journals (Sweden)

    Theodoros Kelesidis

    Full Text Available Current cell-based assays for determining the functional properties of high-density lipoproteins (HDL have limitations. We report here the development of a new, robust fluorometric cell-free biochemical assay that measures HDL lipid peroxidation (HDLox based on the oxidation of the fluorochrome Amplex Red. HDLox correlated with previously validated cell-based (r = 0.47, p<0.001 and cell-free assays (r = 0.46, p<0.001. HDLox distinguished dysfunctional HDL in established animal models of atherosclerosis and Human Immunodeficiency Virus (HIV patients. Using an immunoaffinity method for capturing HDL, we demonstrate the utility of this novel assay for measuring HDLox in a high throughput format. Furthermore, HDLox correlated significantly with measures of cardiovascular diseases including carotid intima media thickness (r = 0.35, p<0.01 and subendocardial viability ratio (r = -0.21, p = 0.05 and physiological parameters such as metabolic and anthropometric parameters (p<0.05. In conclusion, we report the development of a new fluorometric method that offers a reproducible and rapid means for determining HDL function/quality that is suitable for high throughput implementation.

  13. Densidade de plantio, crescimento, produtividade e qualidade das frutas de morangueiro "Camino Real" em hidroponia

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    Isabelita Pereira Portela

    2012-09-01

    Full Text Available Com o objetivo de determinar o efeito da densidade de plantio sobre o crescimento da planta, a produtividade e características químicas relacionadas à qualidade organoléptica das frutas da cultivar de morangueiro Camino Real em sistema hidropônico do tipo NFT, diferentes densidades de plantio foram avaliadas: 15,0; 12,5; 10,7 e 9,3 plantas m-2, correspondentes ao espaçamento entre plantas de 0,25; 0,30; 0,35 e 0,40 m, sendo fixado o espaçamento entre linhas de 0,18 m. O sistema NFT foi constituído por bancadas de telhas de fibrocimento de 1,10 x 2,44 m, considerando-se cada ondulação côncava da telha como um canal de cultivo. O transplante foi realizado em 26-04-2010, encerrando-se o experimento em 05-01-2011. Avaliaram-se a matéria fresca e seca de folhas, coroa, raízes e frutas, a área foliar, o número de frutas e o peso médio das frutas. Amostras das frutas foram analisadas em relação ao teor de sólidos solúveis totais (SST e à acidez total titulável (ATT. Com base nos resultados obtidos, conclui-se que o crescimento e a produtividade individual das plantas da cultivar de morangueiro Camino Real não são afetados pela elevação da densidade de plantio, no intervalo entre 9,3 e 15,0 plantas m-2. O crescimento e a produtividade por unidade de área, bem como a concentração de sólidos solúveis totais e a relação SST/ATT apresentam resposta linear ao incremento da densidade de plantio. Sugere-se a adoção da densidade de 12,5 plantas m-2, que proporcionaria rendimento mais elevado (2,79 kg m-2 de frutas com adequadas características organolépticas e redução no número de mudas necessárias, em relação à densidade de 15,0 plantas m-2. Existe a necessidade de desenvolver estudos adicionais com a cultivar Camino Real, a fim de promover adaptações no sistema e verificar a viabilidade econômica de seu cultivo em hidroponia.

  14. A tomografia computadorizada de alta resolução na avaliação da toxicidade pulmonar por amiodarona High-resolution computed tomography of amiodarone pulmonary toxicity

    Directory of Open Access Journals (Sweden)

    Daniela Peixoto Consídera

    2006-04-01

    Full Text Available OBJETIVO: Avaliar as principais alterações identificadas na tomografia computadorizada de alta resolução do tórax em pacientes com toxicidade pulmonar pela amiodarona. MATERIAIS E MÉTODOS: Foram avaliadas dez tomografias computadorizadas de alta resolução de tórax de pacientes com pneumonite pela amiodarona, seis desses pacientes do sexo masculino e quatro do sexo feminino, com idade média de 73,5 anos. RESULTADOS: Os achados tomográficos mais relevantes foram opacidades lineares ou reticulares em seis casos (60%, pequenos nódulos com densidade elevada em seis casos (60%, consolidações densas em três casos (30% e aumento da densidade do parênquima hepático em cinco de oito casos em que havia estudo tomográfico do abdome superior (62,5%. CONCLUSÃO: A tomografia computadorizada de alta resolução é um exame importante na avaliação de pacientes com toxicidade pulmonar pela amiodarona, devendo ser realizada sempre que houver suspeita deste diagnóstico. O achado de espessamento de septos interlobulares associado a lesões com aumento de densidade é altamente sugestivo deste diagnóstico.OBJECTIVE: To evaluate the main findings of chest high-resolution computed tomography in patients with amiodarone pulmonary toxicity. MATERIALS AND METHODS: Ten patients - six male and four female, average age of 73.5 years - with amiodarone-induced pneumonitis have undergone chest high-resolution computed tomography. RESULTS: The most relevant tomographic findings were linear or reticular opacities in six cases (60%, small high density nodules in six cases (60%, dense consolidations in three cases (30% and increased density in the hepatic parenchyma in five of eight cases in which there was a superior abdomen CT scan (62.5%. CONCLUSION: The high-resolution computed tomography is a valuable non-invasive test for evaluating patients with amiodarone pulmonary toxicity and should always be performed when one suspects of the presence of this

  15. Componentes do rendimento e desenvolvimento do feijoeiro de porte ereto sob diferentes densidades populacionais

    Directory of Open Access Journals (Sweden)

    SHIMADA MARCELO MAMORU

    2000-01-01

    Full Text Available O presente trabalho teve por objetivo verificar a influência de densidades populacionais com variação de 133,3 mil a 533,3 mil plantas por hectare, distribuídas em diferentes espaçamentos entrelinhas (0,30 m; 0,45 m e 0,60 m e número de plantas na linha de semeadura (8, 12 e 16 plantas por metro linear, em componentes do rendimento e no desenvolvimento do feijoeiro (Phaseolus vulgaris L., cultivares IAC-Carioca Pyatã e IAC-Bico de Ouro, de porte semi-ereto a ereto, cultivados sob irrigação no inverno (maio a agosto de 1995, em Selvíria (MS. Obteve-se uma redução do número de vagens e do número de grãos por planta com o aumento da densidade de semeadura por metro linear, ou com a diminuição do espaçamento entrelinhas. Com esse espaçamento reduzido houve um efeito compensatório no rendimento de grãos, devido ao aumento da população de plantas por área, e à maior massa de sementes. Para os cultivares de porte semi-ereto a ereto obtiveram-se maiores rendimentos em grãos na densidade populacional de 266,7 mil plantas por hectare, utilizando-se o espaçamento de 0,30 m entrelinhas e oito plantas por metro linear.

  16. Densidad de la madera en clones de Eucalyptus por densitometría de rayos X

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    Bibiana Arango

    2008-01-01

    Full Text Available En el Brasil y en diversos países se han verificado avances significativos en la silvicultura clonal intensiva con diferencias marcadas entre clones de especies e híbridos de Eucalyptus en lo referente a los parámetros de crecimiento y desarrollo. Al mismo tiempo, en los últimos años, se introdujo el concepto de uso múltiplo del leño de los árboles con la utilización de la madera como fuente de celulosa y papel, madera sólida y otras aplicaciones como estrategia de aumento de la rentabilidad del emprendimiento forestal. El presente trabajo tuvo como objetivo determinar el índice de uniformidad de la madera y la variación de la densidad en el sentido radial por densitometría de rayos X de árboles de 8 años de edad de clones de Eucalyptus grandis y E. grandis x urophylla, buscando posibilitar la optimización de su uso. Por sus características silviculturales se seleccionaron los 5 mejores clones de la especie e híbrido de las plantaciones clonales localizadas en el municipio de San Miguel de Arcanjo-SP de la Cia Suzano de Celulosa y Papel. Se caracterizaron 3 modelos de variación radial de la densidad y la formación de 3 tipos de madera (juvenil, de transición y adulta; el valor medio de densidad aparente de la madera en los clones fue de 0,46 y 0,54 g/cm3, para el Eucalyptus grandis y E. grandis x urophylla, respectivamente.

  17. Parâmetros sangüíneos de pacu Piaractus mesopotamicus (Holmberg, 1887 alimentados com dietas suplementadas com cromo trivalente em duas densidades de estocagem = Hematological parameters of pacu Piaractus mesopotamicus (Holmberg, 1887 fed diets supplemented with trivalent chromium in two stocking densities

    Directory of Open Access Journals (Sweden)

    Rodrigo Yudi Fujimoto

    2007-10-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos da suplementação com cromo trivalente (0, 6, 12 e 18 mg kg-1 de ração sobre as variáveis hematológicas de Piaractus mesopotamicus, mantidos em duas densidades de estocagem (4 e 20 kg m-3. Os mantidos na maior densidade e alimentados com dietas suplementadas com 0 e 6 mg de cromo kg-1apresentaram redução do número de linfócitos circulantes, sugerindo má adaptação a essa condição de alta densidade. Nas dietas suplementadas com 12 e 18 mg kg-1, tal efeito não foi observado, porém verificou-se aumento do número de trombócitos no tratamento com 12 mg de cromo kg-1. A inexistência de diferença significativa entre os tratamentos, aos 30 dias, sugere a adaptação dos peixes ao tipo de alimento e à situação de alta densidade. Portanto, nas condições deste ensaio, a suplementação com 12 e 18 mg de cromo kg-1 é interessante como estratégia alimentar durante 15 dias.This work evaluated the effects of chromium supplementation on thehematological parameters of Piaractus mesopotamicus Holmberg, 1887 maintained in two stocking densities. Fish were fed diets supplemented with 0, 6, 12 and 18 mg trivalent chromium kg-1 dry ration and maintained at 4 and 20 kg m-3. The fish under high stockingdensity and fed diets supplemented with 0 and 6 mg kg-1 showed reduction in the number lymphocytes, which suggests non-adaptation to this condition of high density. This was not observed in fish fed diets supplemented with 12 and 18 mg chromium kg-1, but an increasein the number of thrombocytes was evident. The lack of difference between treatments after 30 days may suggest a possible adaptation of fish to the situation. It can be added that supplementation with 12 and 18 mg chromium kg-1 is an interesting feeding strategy for aperiod of 15 days.

  18. Sostenibilidad de sistemas ganaderos bovinos de alta montaña en Colombia

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    Raúl Andrés Molina Benavides

    2017-09-01

    Full Text Available La complejidad de los sistemas agropecuarios dadas sus múltiples interacciones de elementos bióticos y abióticos, hace que estudios integrales sean importantes para un mejor entendimiento y actuación frente a éstos. Este trabajo tuvo como objetivo estudiar la sostenibilidad de 8 sistemas ganaderos alto andinos. Se encontró en promedio carga animal de 0,5 UGG, producción de leche de 4 kg/vaca/día, intervalos de partos de 450 días y producciones de forraje de 2,45 t MS/ha con 14% PC y 60% FDN. En promedio para el bosque, el carbono orgánico del suelo fue de 33,72 t/ha y para los potreros de pastoreo de 25,29 t/ha, siendo significativa la diferencia (p≤0,05. No se encontró diferencias (p≥0,05 entre las densidades aparentes en el suelo de los bosques nativos (0,46g/cm3 y los potreros (0,5 g/cm3. Las cantidades de CO2 equivalente (CO2eq producidas en promedio  fueron de 76,12 t/predio (65,5 t CO2eq correspondientes a la producción de CH4 y 10,87 t CO2eq a la producción de N2O. El agua virtual requerida en promedio para los bovinos fue de 16.222,26 m3 para cubrir sus necesidades de alimento, bebida y servicios (10 años, y para producir un litro de leche requerían 1,78 m3. En el aspecto social los indicadores con menor calificación fueron servicios públicos y acceso a educación. En conclusión y sabiendo que la sostenibilidad se logra cuando hay un balance entre los componentes económico, ambiental y social; los resultados encontrados permiten afirmar que los sistemas productivos ganaderos de alta montaña incluidos en este trabajo no son sostenibles.

  19. LOBECTOMÍA EN RATAS: MODELO QUIRÚRGICO EXPERIMENTAL. RESULTADOS EN LA DENSIDAD ALVEOLAR

    OpenAIRE

    Martínez M,Mónica; Velázquez S,Nelson; Flores A,Emilio; Navarrete H,Andrés; Zúñiga H,Felipe; Zitko M,Pedro; García B,Cristián; González B,Sergio; Zúñiga R,Sergio

    2014-01-01

    Introducción: En la literatura está documentado que diferentes mamíferos tienen la capacidad de crecimiento compensatorio post resección pulmonar parcial. Objetivo: Crear un modelo quirúrgico de lobectomía en ratas, factible de desarrollar en nuestro medio, exponiendo algunas originalidades en relación a procedimientos de ventilación pulmonar, comunicando los resultados de la densidad alveolar obtenidos. Animales y Métodos: Se utilizaron 47 ratas Rattus norvegicus. Se aplicó como anestesia At...

  20. Tenacidade da madeira como função da densidade aparente

    OpenAIRE

    Diego Henrique de Almeida; Ricardo de Mello Scaliante; André Luis Christoforo; Luciano Donizeti Varanda; Francisco Antonio Rocco Lahr; Antonio Alves Dias; Carlito Calil Junior

    2014-01-01

    O conhecimento do comportamento da madeira mediante ações de curta duração contribui para um projeto estrutural mais seguro, entretanto não sendo a tenacidade parte integrante das propriedades mecânicas comumente investigadas na caracterização deste material. Este trabalho objetivou avaliar, com o uso de modelos de regressões polinomial linear, quadrática e cúbica, a possibilidade da estimativa da tenacidade com o conhecimento da densidade aparente de seis espécies de madeira (Angico, Eucalip...

  1. Densidade e anatomia da madeira em famílias melhoradas de salgueiros na Argentina

    OpenAIRE

    Monteoliva, Silvia Estela; Cerrillo, Teresa

    2016-01-01

    El objetivo del trabajo fue la evaluación de densidad y anatomía de la madera en siete familias de sauces con vistas a seleccionar clones aptos para la producción de madera para usos sólidos y papel. Se cruzaron progenitores de cinco especies de sauces (S. babylonica, S. alba, S. nigra, S. amygdaloides y S. matsudana) obteniéndose 1800 individuos producto de cruzamientos controlados y polinización abierta, dentro del programa de mejoramiento de sauces del INTA. A los 34 meses se efectuó ...

  2. Longitudinal study of alcohol consumption and HDL concentrations: a community-based study12

    Science.gov (United States)

    Li, Junjuan; Shearer, Gregory C; Lichtenstein, Alice H; Zheng, Xiaoming; Wu, Yuntao; Jin, Cheng; Wu, Shouling

    2017-01-01

    Background: In cross-sectional studies and short-term clinical trials, it has been suggested that there is a positive dose-response relation between alcohol consumption and HDL concentrations. However, prospective data have been limited. Objective: We sought to determine the association between total alcohol intake, the type of alcohol-containing beverage, and the 6-y (2006–2012) longitudinal change in HDL-cholesterol concentrations in a community-based cohort. Design: A total of 71,379 Chinese adults (mean age: 50 y) who were free of cardiovascular diseases and cancer and did not use cholesterol-lowering agents during follow-up were included in the study. Alcohol intake was assessed via a questionnaire in 2006 (baseline), and participants were classified into the following categories of alcohol consumption: never, past, light (women: 0–0.4 servings/d; men: 0–0.9 servings/d), moderate (women: 0.5–1.0 servings/d; men: 1–2 servings/d), and heavy (women: >1.0 servings/d; men: >2 servings/d). HDL-cholesterol concentrations were measured in 2006, 2008, 2010, and 2012. We used generalized estimating equation models to examine the associations between baseline alcohol intake and the change in HDL-cholesterol concentrations with adjustment for age, sex, smoking, physical activity, obesity, hypertension, diabetes, liver function, and C-reactive protein concentrations. Results: An umbrella-shaped association was observed between total alcohol consumption and changes in HDL-cholesterol concentrations. Compared with never drinkers, past, light, moderate, and heavy drinkers experienced slower decreases in HDL cholesterol of 0.012 mmol · L−1 · y−1 (95% CI: 0.008, 0.016 mmol · L−1 · y−1), 0.013 mmol · L−1 · y−1 (95% CI: 0.010, 0.016 mmol · L−1 · y−1), 0.017 mmol · L−1 · y−1 (95% CI: 0.009, 0.025 mmol · L−1 · y−1), and 0.008 mmol · L−1 · y−1 (95% CI: 0.005, 0.011 mmol · L−1 · y−1), respectively (P alcohol consumption was

  3. Longitudinal study of alcohol consumption and HDL concentrations: a community-based study.

    Science.gov (United States)

    Huang, Shue; Li, Junjuan; Shearer, Gregory C; Lichtenstein, Alice H; Zheng, Xiaoming; Wu, Yuntao; Jin, Cheng; Wu, Shouling; Gao, Xiang

    2017-04-01

    Background: In cross-sectional studies and short-term clinical trials, it has been suggested that there is a positive dose-response relation between alcohol consumption and HDL concentrations. However, prospective data have been limited. Objective: We sought to determine the association between total alcohol intake, the type of alcohol-containing beverage, and the 6-y (2006-2012) longitudinal change in HDL-cholesterol concentrations in a community-based cohort. Design: A total of 71,379 Chinese adults (mean age: 50 y) who were free of cardiovascular diseases and cancer and did not use cholesterol-lowering agents during follow-up were included in the study. Alcohol intake was assessed via a questionnaire in 2006 (baseline), and participants were classified into the following categories of alcohol consumption: never, past, light (women: 0-0.4 servings/d; men: 0-0.9 servings/d), moderate (women: 0.5-1.0 servings/d; men: 1-2 servings/d), and heavy (women: >1.0 servings/d; men: >2 servings/d). HDL-cholesterol concentrations were measured in 2006, 2008, 2010, and 2012. We used generalized estimating equation models to examine the associations between baseline alcohol intake and the change in HDL-cholesterol concentrations with adjustment for age, sex, smoking, physical activity, obesity, hypertension, diabetes, liver function, and C-reactive protein concentrations. Results: An umbrella-shaped association was observed between total alcohol consumption and changes in HDL-cholesterol concentrations. Compared with never drinkers, past, light, moderate, and heavy drinkers experienced slower decreases in HDL cholesterol of 0.012 mmol · L -1 · y -1 (95% CI: 0.008, 0.016 mmol · L -1 · y -1 ), 0.013 mmol · L -1 · y -1 (95% CI: 0.010, 0.016 mmol · L -1 · y -1 ), 0.017 mmol · L -1 · y -1 (95% CI: 0.009, 0.025 mmol · L -1 · y -1 ), and 0.008 mmol · L -1 · y -1 (95% CI: 0.005, 0.011 mmol · L -1 · y -1 ), respectively ( P alcohol consumption was associated with the

  4. Avaliação da densidade populacional e regeneração natural do palmito juçara (Euterpe edulis Mart. no município de São João Evangelista-MG

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    Paulo do Nascimento

    2015-07-01

    Full Text Available Este trabalho foi desenvolvido em uma população de E. edulis (palmito juçara em uma área de 4.5 hectares da fazenda Nova Granja de 363 hectares, em São João Evangelista, MG. Objetivou-se analisar a estrutura populacional dessa espécie em Floresta Estacional Semidecidual Montana, compreender sua dinâmica e contribuir com informações  sobre o manejo sustentado de E. edulis nesse tipo de ambiente. Os dados da população foram coletados em 10 parcelas de 10 x 15 m, alocadas em três transectos dispostos em nordeste-sudoeste, com 175 m de distância entre si. Coletaram-se dados referentes a cinco estádios de desenvolvimento (Jovem I, Jovem II, Imaturo I, Imaturo II e Adulto e avaliaram-se a densidade e a regeneração dessa população. Foi encontrado grande percentual de Jovem I. Adultos com altura de inserção foliar entre 14,3 e 18,3 m foram a classe mais frequente nessa população. A densidade populacional apresentou-se relativamente alta (0,74/m2; a população possui distribuição em “J” invertido, sendo uma população em estado natural de conservação. Palavras-chave: Palmeira juçara. “J” invertido. Arecaceae.

  5. Determinação da densidade relativa do solo por uma função de pedotransferência para a densidade do solo máxima

    OpenAIRE

    Marcolin,Clovis Dalri; Klein,Vilson Antonio

    2011-01-01

    O objetivo desse trabalho foi estimar a densidade relativa do solo (DR) a partir de uma função de pedotransferência para a densidade do solo máxima (Ds máx). Amostras de dez solos, em sistema de plantio direto estabelecido há mais de dez anos, foram coletadas no Estado do Rio Grande do Sul, em camadas de 5 até 30 cm de profundidade, com a estrutura preservada e não-preservada. Determinaram-se a granulometria, os teores de matéria orgânica (MO), a densidade do solo (Ds) e a Ds do solo máxima (...

  6. New insights into the determination of HDL structure by apolipoproteins1

    Science.gov (United States)

    Phillips, Michael C.

    2013-01-01

    Apolipoprotein (apo)A-I is the principal protein component of HDL, and because of its conformational adaptability, it can stabilize all HDL subclasses. The amphipathic α-helix is the structural motif that enables apoA-I to achieve this functionality. In the lipid-free state, the helical segments unfold and refold in seconds and are located in the N-terminal two thirds of the molecule where they are loosely packed as a dynamic, four-helix bundle. The C-terminal third of the protein forms an intrinsically disordered domain that mediates initial binding to phospholipid surfaces, which occurs with coupled α-helix formation. The lipid affinity of apoA-I confers detergent-like properties; it can solubilize vesicular phospholipids to create discoidal HDL particles with diameters of approximately 10 nm. Such particles contain a segment of phospholipid bilayer and are stabilized by two apoA-I molecules that are arranged in an anti-parallel, double-belt conformation around the edge of the disc, shielding the hydrophobic phospholipid acyl chains from exposure to water. The apoA-I molecules are in a highly dynamic state, and they stabilize discoidal particles of different sizes by certain segments forming loops that detach reversibly from the particle surface. The flexible apoA-I molecule adapts to the surface of spherical HDL particles by bending and forming a stabilizing trefoil scaffold structure. The above characteristics of apoA-I enable it to partner with ABCA1 in mediating efflux of cellular phospholipid and cholesterol and formation of a heterogeneous population of nascent HDL particles. Novel insights into the structure-function relationships of apoA-I should help reveal mechanisms by which HDL subclass distribution can be manipulated. PMID:23230082

  7. Pre-clinical evaluation of rHDL encapsulated retinoids for the treatment of Neuroblastoma

    Directory of Open Access Journals (Sweden)

    Nirupama eSabnis

    2013-03-01

    Full Text Available Despite major advances in pediatric cancer research, there has been only modest progress in the survival of children with high risk neuroblastoma (HRNB. The long term survival rates of HRNB in the United States are still only 30-50%. Due to resistance that often develops during therapy, development of new effective strategies is essential to improve the survival and overcome the tendency of HRNB patients to relapse subsequent to initial treatment. Current chemotherapy regimens also have a serious limitation due to off target toxicity. In the present work, we evaluated the potential application of reconstituted high density lipoprotein (rHDL containing fenretinide (FR nanoparticles as a novel approach to current neuroblastoma therapeutics. The characterization and stability studies of rHDL-FR nanoparticles showed small size (<40nm and high encapsulation efficiency. The cytotoxicity studies of free FR vs. rHDL/ FR towards the neuroblastoma cell lines SK-N-SH and SMS-KCNR showed 2.8 and 2 fold lower IC50 values for the rHDL encapsulated FR vs. free FR. More importantly, the IC50 value for retinal pigment epithelial cells (ARPE-19, a recipient of off target toxicity during FR therapy, was over 40 times higher for the rHDL/ FR as compared to that of free FR. The overall improvement in in vitro selective therapeutic efficiency was thus about 100 fold upon encapsulation of the drug into the rHDL nanoparticles. These studies support the potential value of this novel drug delivery platform for treating pediatric cancers in general, and neuroblastoma in particular

  8. Competition in a rice - cowpea intercrop as affected by nitrogen fertilizer and plant population Competição em uma cultura consorciada de arroz-guandu em função do fertilizante nitrogenado e da densidade populacional de plantas

    Directory of Open Access Journals (Sweden)

    Frank Oke Oroka

    2007-12-01

    Full Text Available The increased productivity or yield advantage provided by intercropping is attributed to a better use of resources by crops grown in mixtures, as compared to the same species grown in sole stands. In an intercropping system with upland rice and cowpea, the intra and inter-competition was quantified, as affected by plant population density and rate of nitrogen. Reductions in number of panicles per rice plant and number of grains per panicle were obtained with high density in both sole and mixture rice populations. Increasing nitrogen rate did not affect yield and yield components in both populations, but number and weight of pods per plant of cowpea in sole stands increased. Land equivalent ratios exceeding unity were obtained, indicating an improved resource use by the crop mixture. Relative crowding coefficient and aggressivity indices showed cowpea to be the dominant crop, with rice being dominated. Nitrogen utilization efficiency was high with intercrops, but was generally poor in stands of high population density.O aumento em produtividade devido a plantios consorciados é atribuído ao melhor uso dos recursos presentes pelas plantas em desenvolvimento conjunto, em comparação às mesmas espécies crescendo em dosséis separados. Em um sistema consorciado de arroz e guandu quantificou-se as inter- e intra competições em relação à densidade populacional e taxa de aplicação de nitrogênio. Reduções significativas do número de panículas por planta de arroz e número de grãos por panícula foram observados para alta densidade, tanto para culturas solteira de arroz como em populações mistas. O aumento das doses de nitrogênio não afetou a produção e os componentes de produção em ambos os sistemas, ao passo que o número e peso de vagens por planta do guandu aumentaram em culturas solteiras. Foram obtidas razões de área equivalente maiores que a unidade, mostrando melhoria no uso da terra nas culturas mistas. O coeficiente

  9. Avaliação de milhos de diferentes densidades para frangos de corte Evaluation of corn with different densities for broilers

    Directory of Open Access Journals (Sweden)

    Cynthia Siqueira Silva

    2011-07-01

    Full Text Available O trabalho foi realizado com o objetivo de determinar os valores nutricionais de milhos de quatro qualidades, obtidos por meio de estratificação em mesa densimétrica, para frangos de corte em diferentes idades. Os milhos foram designados como: MDA - milho de densidade alta; MDI - milho de densidade intermediária; MDB - milho de densidade baixa; e MDO milho de densidade original, composto de 25% de MDA, 50% de MDI e 25% de MDB. Três ensaios biológicos foram conduzidos utilizando-se o método tradicional de coleta total de excretas para determinação da energia metabolizável aparente corrigida (EMAn. O primeiro ensaio metabólico foi conduzido com pintos Cobb de 14 a 17 dias, o segundo, com pintos de 25 a 28 dias e o terceiro de 38 a 41 dias de idade. Foram realizadas análises químicas para determinação do perfil nutricional, classificação de grãos segundo a densidade e comparação por meio das estimativas de equações de predição do valor energético. Os valores da EMAn dos milhos de diferentes qualidades (MDA, MDI, MDB e MDO determinados com frangos na fase inicial foram: 3562, 3382, 3198 e 3357 kcal/kg, para a fase de crescimento: 3576, 3555, 3229 e 3416 kcal/kg e, para a fase final 3610, 3554, 3354 e 3585 kcal/kg, respectivamente. Esses valores comprovam as significativas perdas energéticas dos milhos de mais baixa qualidade e a eficiência da mesa densimétrica em estratificar os grãos. A diferença da EMAn entre as idades das aves sugere melhor eficiência de utilização da energia com o avanço da idade. As equações de predição podem ser utilizadas para estimar o valor energético de milhos, tanto por sua classificação como pelas análises bromatológicas. Entretanto, o erro sistemático associado a cada equação de predição pode comprometer a exatidão de seu valor nutricional.The objective of this work was to determine the nutritional value of corn of four different qualities, obtained by stratification in

  10. [Epidemiology of urinary calculi in the Marina Alta (Alicante) region].

    Science.gov (United States)

    Romero Pérez, P; Amat Cecilia, M

    1992-06-01

    An epidemiological study on urolithiasis was conducted in the Borough of Marina Alta from December 1989 to December 1990. The Health Care region of Marina Alta includes 11 health care areas, all centralized into one single Local Hospital offering service to an estimated population of 125,290 inhabitants, which experiences a remarkable increase over the summer months. During the study period 1,792 patients, 350 (20%) of which were lithiasis cases were seen in the Urology Unit. 2.80 per thousand of the studied population had urolithiasis-related signs. Incidence is higher in males than in females, as well as in patients with prior lithiasic diseases, surgery and urinary infections. Urinary infection was present in 20% of patients. Nine percent of patients had some type of associated urinary malformation. The most frequent mineral composition of the lithiasis was: Calcium oxalate (52%), uric acid (20%) and oxalate plus uric acid (9%).

  11. [Lipoproteins HDL and coronary artery disease: a molecular mechanism of fibrate].

    Science.gov (United States)

    Kaletha, Krystian; Chodorowski, Zygmunt; Anand, Izabela Sein; Rybakowska, Iwona; Nagel-Starczynowska, Gabriela

    2003-01-01

    The importance of dyslipidemia in the development of cardiovascular disease is now recognized as a central factor of equal, if not greater significance than any other risk factor. Although correction of high level of low-density lipoproteins (LDL) has been regarded now as the main goal of therapy, it has now been reaffirmed that the contribution of low level of high-density lipoproteins (HDL) to the risk of ischaemic heart disease should also be considered. In the therapy of dislipidemias with hipertriglyceridemia and decreased level of HDL lipoprotein fibrates play an especially important role. In the article the molecular mechanism of fibrates action is presented.

  12. CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake.

    Directory of Open Access Journals (Sweden)

    Heidi J Silver

    Full Text Available Success in further reducing the burden of cardiovascular disease (CVD is threatened by the increasing prevalence of obesity-related atherogenic dyslipidemia. HDL-cholesterol (HDL-C level is inversely correlated with CVD risk; each 1 mg/dl decrease in HDL-C is associated with a 6% reduction in risk. We previously showed that a common CNR1 haplotype, H3 (frequency 20%, is protective against the reduction in HDL-C that typically accompanies weight gain. In the present study, we extend that observation by reporting the effect of CNR1 haplotype on HDL-C response to modification of dietary fat intake in weight maintenance and weight loss.Six haplotype tagging SNPs that cover the CNR1 gene locus were genotyped in 590 adults of varying body mass index (cohort 1 is 411 males with BMI 18.5-30.0 kg/m(2; cohort 2 is 71 females with BMI18.5-30.0 kg/m(2; and cohort 3 is 108 females with BMI 30-39.9 kg/m(2. Dietary intakes were modified so that fat intake in the "high fat" condition was 15-20% greater than in the "low fat" condition, and lipid profiles were compared between carriers versus noncarriers for each of the five commonly observed CNR1 haplotypes (H1-H5.In normal to overweight subjects on eucaloric diets, the H3 haplotype was significantly associated with short-term high fat diet induced changes in HDL-C level in females (carriers 5.9 mg/dl>noncarriers, p = 0.007. The H3 haplotype was also significantly associated with HDL-C level after 16 weeks on high fat calorie restricted diet in obese females (carriers 6.8 mg/dl>noncarriers, p = 0.009.Variability within the CNR1 gene locus contributes to gender-related differences in the HDL-cholesterol response to change in dietary fat intake. Functional characterization of this relationship in vitro may offer insights that potentially yield therapeutic guidance targeting dietary macronutrient composition, a direction much needed in the current epidemic of obesity.

  13. Alcohol-independent beneficial cardiometabolic profile of individuals with hyper-HDL cholesterolemia in Japanese men and women.

    Science.gov (United States)

    Wakabayashi, Ichiro; Daimon, Takashi

    2015-01-01

    There is limited information on characterization of individuals with hyper-high-density lipoprotein (HDL) cholesterolemia. The purpose of this study was to investigate the cardiometabolic profile of individuals with hyper-HDL cholesterolemia in comparison with the profile of individuals with normo-HDL cholesterolemia. The subjects were Japanese men and women who had hyper-HDL cholesterolemia (≥100 mg/dL) and their control subjects who had normal HDL cholesterol levels (≥40 and hyper- and normo-HDL cholesterolemic groups. Both in men and women, body mass index, waist-to-height ratio, triglycerides, low-density lipoprotein cholesterol, and hemoglobin A1c were significantly lower in subjects with hyper-HDL cholesterolemia than in subjects with normo-HDL cholesterolemia, whereas systolic and diastolic blood pressure levels were not significantly different between the 2 groups. In generalized estimating equation with adjustment for smoking and regular exercise, odds ratios of the hyper- vs normo-HDL cholesterolemic groups were significantly lower than the reference level of 1.00 for high body mass index, high waist-to-height ratio, hypertriglyceridemia, hyper-low-density lipoprotein cholesterolemia, high lipid accumulation product, and metabolic syndrome. The previously mentioned results were obtained both in age-matched analysis and in age- and alcohol intake-matched analysis, although the percentage of regular drinkers was significantly higher in the hyper-HDL cholesterolemic group than in the age-matched control group. Hyper-HDL cholesterolemia was inversely associated with obesity, dyslipidemia, and metabolic syndrome in the analysis using alcohol intake-matched subject groups. Therefore, the association of hyper-HDL cholesterolemia with lower cardiometabolic risk is thought to be independent of habitual alcohol drinking. Copyright © 2015 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  14. HDL acceptor capacities for cholesterol efflux from macrophages and lipid transfer are both acutely reduced after myocardial infarction.

    Science.gov (United States)

    Soares, Alexandre A S; Tavoni, Thauany M; de Faria, Eliane C; Remalay, Alan T; Maranhão, Raul C; Sposito, Andrei C

    2018-03-01

    The transport of lipids from the artery wall is one of the most essential anti-atherogenic functions of high-density lipoprotein (HDL). Recent reports of changes in the HDL composition, during myocardial infarction (MI), suggest that this function may be altered. Forty-one consecutive patients with ST-segment elevation MI enrolled at the Brasilia Heart Study were selected. The following HDL-related measures were determined upon admission (D1) and on the fifth day (D5) after MI: C-reactive protein, CETP and PLTP activity, HDL composition, efflux of cholesterol from J774 macrophages to HDL, and transfer of unesterified and esterified cholesterol, triglycerides and phospholipids from a donor nanoemulsion to HDL. From D1 to D5, the activity of CETP decreased by 25%, but PLTP activity remained unchanged. Esterified cholesterol (-23%) and phospholipid (-9.5%) contents of HDL decreased. Transfer of triglycerides (-36.5%) and esterified cholesterol (-14.7%) to HDL from nanoemulsions was reduced, but other lipids transfers were unchanged. Cholesterol efflux to HDL was also diminished by 8.5% (p=0.04) on D5 compared to D1. It was more pronounced in patients above the 75th percentile of C-reactive protein. After an MI, a simultaneous decrease in lipid transfer to HDL and in the capacity of HDL to efflux cholesterol from cells occurs. Thus, HDL with inferior atheroprotective properties may be generated in the acute post-MI period. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Cuaderno de Prácticas: Altas Capacidades

    OpenAIRE

    García-Fernández, José Manuel; Vicent, María; Gonzálvez, Carolina

    2016-01-01

    Este material, centrado en el estudio de las Altas Capacidades, pretende favorecer la adquisición de destrezas en el conocimiento e intervención en el ámbito de la educación especial para conocer de primera mano las diferentes formas que se tienen para actuar e intervenir ante niños con necesidades específicas de apoyo educativo.

  16. Evaluación de densidades de siembra en tomate (Lycopersicon esculentum Mill en invernadero

    Directory of Open Access Journals (Sweden)

    Jos\\u00E9 Cruz Carrillo

    2003-01-01

    Full Text Available Esta investigación se realizó de junio a diciembre del 2001 en el módulo de horticultura protegida del Instituto Tecnológico Agropecuario de Oaxaca No. 23 ubicado en la ex Hacienda de Nazareno, Xoxocotlan, Oax., con el propósito de evaluar el efecto de tres densidades de plantación en el desarrollo vegetativo y producci ón de diferentes híbridos de tomate con crecimiento indeterminado cultivados bajo invernadero. Los híbridos de tomate fueron el SXT, DRW3410 y SXT0289. No hubo diferencia estad ística para los híbridos, sólo para densidades de plantación, obteniendo los mejores rendimientos 5,3 plantas/m2 y 4 plantas/ m2 con 17,52 y 17,37 kg/m2, respectivamente, lo que represent ó en promedio un rendimiento de 151,6 t/ha.

  17. HUBUNGAN ANTARA AKTIVITAS FISIK DAN ANGKA KECUKUPAN GIZI MAKRONUTRIEN TERHADAP RASIO KOLESTEROL TOTAL/HDL PADA MASYARAKAT PEDESAAN

    Directory of Open Access Journals (Sweden)

    Utari Febrina Supomo Sunu

    2017-05-01

    Full Text Available Cardiovascular disease is the number one cause of death in the world. The diseaseis influenced by several factors such as lack of physical activity, imbalanced nutritional intake, and high blood cholesterol levels. The value of the total cholesterol / HDL can predict cardiovascular disease risk factors.  The study aims to investigate the relationship between physical activity and Dietary Allowances of the macronutrient and ratio total cholesterol / HDL in rural communities. This is observational analytic with cross-sectional design of the 102 respondents (male: 40, female: 62 in Kepuharjo village, Cangkringan, Sleman, Yogyakarta, with a purposive sampling techniques. Physical activity data were taken using a structured interview (Baecke and Semi Quantitive Food Frequency Questionnaire (SQFFQ for data macronutrient, while blood total cholesterol and HDL-cholesterol levels  were analyzed using enzymatic methods. The results of the study showed that there is no significant relationship between physical activity and the ratio of total cholesterol / HDL (p = 0.038; CI 95%: 0.98-61.33, dietary allowances of the macronutrient energy and the ratio of total cholesterol / HDL (p = 0.068, protein intake on the ratio of total cholesterol / HDL (p = 1.000, fat intake to the ratio of total cholesterol / HDL (p = 0.081, and the intake of carbohydrates to the ratio of total cholesterol / HDL (p = 0.088. In conclusion  there is no significant relationship between physical activity and dietary allowance of macronutrient towards to the ratio of total cholesterol / HDL.

  18. Densidade e diversidade fenotípica de bactérias diazotróficas não simbióticas em solos da Reserva Biológica Serra dos Toledos, Itajubá (MG

    Directory of Open Access Journals (Sweden)

    Talita Filomena Silva

    2011-04-01

    Full Text Available Bactérias diazotróficas não simbióticas (BDNS atuam no desenvolvimento das plantas por meio da fixação biológica de nitrogênio e também pela produção e liberação de substâncias reguladoras do crescimento vegetal. Este estudo objetivou avaliar a densidade e diversidade fenotípica desse grupo de bactérias em fragmentos de solo da Reserva Biológica Serra dos Toledos e entorno, em Itajubá/MG. Essa reserva localiza-se na Área de Proteção Ambiental da Mantiqueira, constituindo-se em uma importante área de recarga e de abrigo à flora e fauna endêmicas. Amostras de solo superficial foram coletadas em áreas com diferentes declividades na reserva, em épocas representativas das estações de inverno (setembro/2006 e verão (abril/2007. A densidade, avaliada pelo número mais provável, utilizando os meios de cultura NFb, JNFb e Fam, para Azospirillum spp., Herbaspirillum spp. e A. amazonense, respectivamente, variou de 0,12 a 75,60 (NMP x 10(5 bactérias g-1 solo seco. Foram obtidos 172 e 174 isolados, respectivamente para as amostras de inverno e verão, dos quais 30 e 55 % apresentaram similaridade igual ou superior a 70 % com as estirpes-tipo Azospirillum brasilense, A. amazonense, A. lipoferum, Herbaspirillum seropedicae e Burkholderia brasilensis. O resultado do comportamento dos isolados com base na tolerância à salinidade nem sempre foi semelhante ao obtido pelas características fenotípicas culturais a 70 % de similaridade, sendo indicado para estudos complementares de diversidade desses organismos. As BDNS apresentam potencial de utilização em estudos de avaliação da qualidade e sustentabilidade de ecossistemas. No entanto, apesar da alta densidade e diversidade fenotípica em solos da reserva, maiores valores foram obtidos no entorno, evidenciando o efeito positivo da cobertura vegetal do tipo gramíneas sobre elas, independentemente da variação climática.

  19. El niño, oscilación del sur (ENOS, con relación a la transmisión de malaria, densidad y paridad de An. albimanus y An. darlingi (diptera: culicidae en dos regiones de Colombia

    Directory of Open Access Journals (Sweden)

    Ricardo Mantilla

    2000-02-01

    Full Text Available

    Una fuerte asociación ha sido registrada entre los incrementos en la transmisiónas forzadas por el fenómeno El Niño. Entre las posibles explicaciones para esta asociación está el efecto del clima sobre la dinámica de población de vectores, por ejemplo, generando cambios en la densidad y en las tasas de sobrevivencia de la población, y en la cantidad y calidad de sitios de reproducción, como también a través de cambios en el período de incubación extrínseco del parásito dentro del vector. Con el propósito de evaluar la influencia de ENOS sobre la densidad y paridad de Anopheles albimanus y An. darlingi, y su relación con la transmisión de malaria, se realizó un estudio longitudinal en Chocó y Casanare. En cada área se seleccionaron dos localidades y se realizaron muestreos entomológicos durante una semana cada mes, desde finales de 1997 hasta 1999. Este período cubrió los eventos El Niño 1997 -1998 y La Niña 1998 - 2000. En las localidades de Chocó se observó un importante incremento en el número de casos de malaria durante el evento ENOS, asociado con la temperatura. No se observó una asociación estadísticamente significativa entre los casos de malaria y la precipitación o la humedad relativa. La relación entre el incremento de malaria durante El Niño y las variables entomológicas no fue evidente. La densidad y paridad de ambas especies de vectores fluctuaron durante el período de estudio y no se encontró una asociación significativa entre estas variables y los factores climáticos como la temperatura. La precipitación y la humedad relativa. La densidad de larvas de An. albimanus fluctuó durante el estudio, y mostró altas densidades alrededor de julio - agosto. No se observó asociación entre la densidad de larvas con la densidad de adultos o las variables climáticas. El efecto del evento ENOS sobre las poblaciones de vectores

  20. Densidad, estructura de tallas y actividad reproductiva del caracol rosado Eustrombus gigas (Mesogastropoda: Strombidae en Banco Chinchorro, México

    Directory of Open Access Journals (Sweden)

    Yuself R Cala

    2013-12-01

    Full Text Available Eustrombus gigas es uno de los recursos pesqueros costeros más valiosos en la región del Caribe y constituye un molusco con un elevado valor estético y ecológico. En esta investigación se evalúa su densidad total, densidad de adultos, la estructura de tallas y frecuencia de evidencias reproductivas en Banco Chinchorro, México, periodo 2009-2010; durante tres períodos (de lluvias, seca y de frentes fríos en tres zonas: Norte, Centro y Sur. La densidad total para el área de estudio varió de 127ind./ha en lluvias a 384ind./ha en seca, la menor densidad se presentó en la zona Norte del Banco (198ind./ha y la mayor en la zona Sur (385ind./ha. La densidad de caracoles adultos fue baja (6.11ind./ha en seca y 8.33ind./ha en lluvias y 5.55, 7.05 y 8.33ind./ha para las zonas Centro, Sur y Norte, respectivamente. Las densidades de adultos estuvieron por debajo del umbral mínimo necesario para mantener la reproducción. El 42% de la población es vulnerable a la pesca (Lsi≥200mm; sin embargo, solo 2.2% de la población alcanza un Gl>15mm. Solo se observaron seis evidencias de reproducción durante el período de estudio, lo que señala la presencia del efecto Allee en la población y la urgente necesidad del cierre de su pesquería. Se proponen tres puntos importantes para el manejo de la especie: cierre de la pesca, monitoreo de la población y la implementación refugios pesqueros

  1. Influencia de la densidad de siembra sobre la estimación de los estados apicales de trigo

    OpenAIRE

    Lerner, Silvia Elena; Abbate, Pablo Eduardo

    1991-01-01

    p.219-226 Con el fin de relacionar aspectos externos con cambios en el desarrollo apical, dos cultivares de trigo, Victoria INTA y Leones INTA, se sembraron a razón de 180, 560 y 930 pl-m² en un diseño factorial con tres bloques el 11 y el 19 de agosto de 1988, respectivamente. Las pendientes de las rectas de regresión entre los estados apicales del vástago principal y la suma térmica fueron diferentes entre densidades; a la mayor densidad correspondió la mayor pendiente y menor suma térmi...

  2. RESISTENCIA MECANICA DE LOS TABLEROS DE DENSIDAD MEDIA: PARTE 1: RESISTENCIA A LA TRACCION PARALELA A LA SUPERFICIE

    OpenAIRE

    Martínez-Espinosa,Mariano; Calil Jr.,Carlito; Fiorelli,Juliano

    2002-01-01

    Los tableros de densidad media "Medium Density Fiberboard" (MDF), representan un caso de particular relevancia, dentro de los materiales de ingeniería. Sin embargo, en Brasil, aun son pocos los trabajos existentes acerca de las propiedades mecánicas de este material. Por tal motivo, este trabajo tiene por finalidad determinar los valores de la resistencia a la tracción paralela a la superficie en tableros de densidad media. Con el objetivo principal de establecer niveles de esfuerzos máximos ...

  3. Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat.

    Science.gov (United States)

    Newman, John W; Kaysen, George A; Hammock, Bruce D; Shearer, Gregory C

    2007-08-01

    We previously established that proteinuria alters the apolipoprotein content of lipoproteins. This study was conducted to establish whether proteinuria also alters the concentrations of oxidized lipids within lipoprotein density fractions. To this end, we induced passive Heymann nephritis in Sprague Dawley rats and measured an array of alkaline-stable oxylipids in VLDL, LDL, and HDL particles. Proteinuria increased the total oxylipid amounts in the HDL and VLDL fractions. More importantly, these levels were increased when expressed per unit lipoprotein protein, indicating that the oxidized lipid load per particle was increased. Epoxides and diols increased approximately 2-fold in HDL and approximately 5-fold in VLDL, whereas LDL showed approximately 2-fold decreases. The hydroxyeicosatetraenoic acids and hydroxyoctadecadienoic acids (HODEs) increased >4-fold in HDL and >20-fold in VLDL, whereas LDL showed approximately 2-fold decreases in the HODEs. Therefore, nephrotic syndrome alters the lipoprotein oxylipid composition independently of an increase in total lipoprotein levels. These proteinuria-induced changes may be associated with the cardiovascular risk of lipoprotein oxidation.

  4. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events

    NARCIS (Netherlands)

    Barter, Philip; Gotto, Antonio M.; LaRosa, John C.; Maroni, Jaman; Szarek, Michael; Grundy, Scott M.; Kastelein, John J. P.; Bittner, Vera; Fruchart, Jean-Charles

    2007-01-01

    BACKGROUND: High-density lipoprotein (HDL) cholesterol levels are a strong inverse predictor of cardiovascular events. However, it is not clear whether this association is maintained at very low levels of low-density lipoprotein (LDL) cholesterol. METHODS: A post hoc analysis of the recently

  5. Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population

    DEFF Research Database (Denmark)

    Frikke-Schmidt, Ruth; Nordestgaard, Børge G; Jensen, Gorm B

    2004-01-01

    and some with consistent trends in men, determined as isolated single-site effects varying only at the relevant SNP. Finally, these results were consistent over time. In conclusion, we show that at least 10% of individuals with low HDL-C in the general population are heterozygous for mutations in ABCA1...

  6. Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial.

    Science.gov (United States)

    Neufingerl, Nicole; Zebregs, Yvonne E M P; Schuring, Ewoud A H; Trautwein, Elke A

    2013-06-01

    Evidence from clinical studies has suggested that cocoa may increase high-density lipoprotein (HDL)-cholesterol concentrations. However, it is unclear whether this effect is attributable to flavonoids or theobromine, both of which are major cocoa components. We investigated whether pure theobromine increases serum HDL cholesterol and whether there is an interaction effect between theobromine and cocoa. The study had a 2-center, double-blind, randomized, placebo-controlled, full factorial parallel design. After a 2-wk run-in period, 152 healthy men and women (aged 40-70 y) were randomly allocated to consume one 200-mL drink/d for 4 wk that contained 1) cocoa, which naturally provided 150 mg theobromine and 325 mg flavonoids [cocoa intervention (CC)], 2) 850 mg pure theobromine [theobromine intervention (TB)], 3) cocoa and added theobromine, which provided 1000 mg theobromine and 325 mg flavonoids [theobromine and cocoa intervention (TB+CC)], or 4) neither cocoa nor theobromine (placebo). Blood lipids and apolipoproteins were measured at the start and end of interventions. In a 2-factor analysis, there was a significant main effect of the TB (P Theobromine independently increased serum HDL-cholesterol concentrations by 0.16 mmol/L. The lack of significant cocoa and interaction effects suggested that theobromine may be the main ingredient responsible for the HDL cholesterol-raising effect. This trial was registered at clinicaltrials.gov as NCT01481389.

  7. HDL does not influence the polarization of human monocytes toward an alternative phenotype

    NARCIS (Netherlands)

    Colin, Sophie; Fanchon, Mélanie; Belloy, Loic; Bochem, Andrea E.; Copin, Corinne; Derudas, Bruno; Stroes, Erik S. G.; Hovingh, G. Kees; Kuivenhoven, Jan A.; Dallinga-Thie, Geesje M.; Staels, Bart; Chinetti-Gbaguidi, Giulia

    2014-01-01

    Macrophages are crucial cells in the pathogenesis of atherosclerosis. Macrophages are plastic cells which can switch from a classical pro-inflammatory M1 to an alternative anti-inflammatory M2 macrophage phenotype, depending on the environmental stimuli. Because high-density lipoprotein (HDL)

  8. Blood-borne LPS is rapidly eliminated by liver sinusoidal endothelial cells via HDL

    Science.gov (United States)

    Yao, Zhili; Mates, Jessica M.; Cheplowitz, Alana M.; Hammer, Lindsay P.; Maiseyeu, Andrei; Phillips, Gary S.; Wewers, Mark D.; Rajaram, Murugesan V.S.; Robinson, John M.; Anderson, Clark L.; Ganesan, Latha P.

    2016-01-01

    During Gram-negative bacterial infections, excessive lipopolysaccharide (LPS) induces inflammation and sepsis via action on immune cells. However, the bulk of LPS can be cleared from circulation by the liver. Liver clearance is thought to be a slow process mediated exclusively by phagocytic resident macrophages, Kupffer cells (KC). However, we discovered that LPS disappears rapidly from the circulation, with a half-life of 2–4 minutes in mice and liver eliminates about three quarters of LPS from blood circulation. Using microscopic techniques, we found that ~75% of fluor-tagged LPS in liver became associated with liver sinusoidal endothelial cells (LSEC) and only ~25% with KC. Notably, the ratio of LSEC-KC associated LPS remained unchanged 45 min after infusion, indicating that LSEC independently processes the LPS. Most interestingly, results of kinetic analysis of LPS bioactivity, using modified limulus amebocyte lysate assay, suggest that recombinant factor-C, an LPS binding protein, competitively inhibits HDL-mediated LPS association with LSEC early in the process. Supporting the previous notion 3 min post-infusion, 75% of infused fluorescently-tagged LPS-HDL complex associates with LSEC, suggesting that HDL facilitates LPS clearance. These results lead us to propose a new paradigm of LSEC and HDL in clearing LPS with a potential to avoid inflammation during sepsis. PMID:27534554

  9. Structure of spheroidal HDL particles revealed by combined atomistic and coarse-grained simulations

    NARCIS (Netherlands)

    Catte, Andrea; Patterson, James C.; Bashtovyy, Denys; Jones, Martin K.; Gu, Feifei; Li, Ling; Rampioni, Aldo; Sengupta, Durba; Vuorela, Timo; Niemela, Perttu; Karttunen, Mikko; Marrink, Siewert Jan; Vattulainen, Ilpo; Segrest, Jere P.

    2008-01-01

    Spheroidal high-density lipoprotein (HDL) particles circulating in the blood are formed through an enzymatic process activated by apoA-1, leading to the esterification of cholesterol, which creates a hydrophobic core of cholesteryl ester molecules in the middle of the discoidal phospholipid bilayer.

  10. Plasma HDL cholesterol and risk of myocardial infarction : A mendelian randomisation study

    NARCIS (Netherlands)

    Voight, Benjamin F.; Peloso, Gina M.; Orho-Melander, Marju; Frikke-Schmidt, Ruth; Barbalic, Maja; Jensen, Majken K.; Hindy, George; Holm, Hilma; Ding, Eric L.; Johnson, Toby; Schunkert, Heribert; Samani, Nilesh J.; Clarke, Robert; Hopewell, Jemma C.; Thompson, John F.; Li, Mingyao; Thorleifsson, Gudmar; Newton-Cheh, Christopher; Musunuru, Kiran; Pirruccello, James P.; Saleheen, Danish; Chen, Li; Stewart, Alexandre F. R.; Schillert, Arne; Thorsteinsdottir, Unnur; Thorgeirsson, Gudmundur; Anand, Sonia; Engert, James C.; Morgan, Thomas; Spertus, John; Stoll, Monika; Berger, Klaus; Martinelli, Nicola; Girelli, Domenico; McKeown, Pascal P.; Patterson, Christopher C.; Epstein, Stephen E.; Devaney, Joseph; Burnett, Mary-Susan; Mooser, Vincent; Ripatti, Samuli; Surakka, Ida; Nieminen, Markku S.; Sinisalo, Juha; Lokki, Marja-Liisa; Perola, Markus; Havulinna, Aki; de Faire, Ulf; Gigante, Bruna; Ingelsson, Erik; Zeller, Tanja; Wild, Philipp; de Bakker, Paul I. W.; Klungel, Olaf H.; Maitland-van der Zee, Anke-Hilse; Peters, Bas J. M.; de Boer, Anthonius; Grobbee, Diederick E.; Kamphuisen, Pieter W.; Deneer, Vera H. M.; Elbers, Clara C.; Onland-Moret, N. Charlotte; Hofker, Marten H.; Wijmenga, Cisca; Verschuren, W. M. Monique; Boer, Jolanda M. A.; van der Schouw, Yvonne T.; Rasheed, Asif; Frossard, Philippe; Demissie, Serkalem; Willer, Cristen; Do, Ron; Ordovas, Jose M.; Abecasis, Goncalo R.; Boehnke, Michael; Mohlke, Karen L.; Daly, Mark J.; Guiducci, Candace; Burtt, Noel P.; Surti, Aarti; Gonzalez, Elena; Purcell, Shaun; Gabriel, Stacey; Marrugat, Jaume; Peden, John; Erdmann, Jeanette; Diemert, Patrick; Willenborg, Christina; Koenig, Inke R.; Fischer, Marcus; Hengstenberg, Christian; Ziegler, Andreas; Buysschaert, Ian; Lambrechts, Diether; Van de Werf, Frans; Fox, Keith A.; El Mokhtari, Nour Eddine; Rubin, Diana; Schrezenmeir, Juergen; Schreiber, Stefan; Schaefer, Arne; Danesh, John; Blankenberg, Stefan; Roberts, Robert; McPherson, Ruth; Watkins, Hugh; Hall, Alistair S.; Overvad, Kim; Rimm, Eric; Boerwinkle, Eric; Tybjaerg-Hansen, Anne; Cupples, L. Adrienne; Reilly, Muredach P.; Melander, Olle; Mannucci, Pier M.; Ardissino, Diego; Siscovick, David; Elosua, Roberto; Stefansson, Kari; O'Donnell, Christopher J.; Salomaa, Veikko; Rader, Daniel J.; Peltonen, Leena; Schwartz, Stephen M.; Altshuler, David; Kathiresan, Sekar

    2012-01-01

    Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease

  11. HUBUNGAN ASUPAN ENERGI, LEMAK DAN SERAT DENGAN RASIO KADAR KOLESTEROL TOTAL-HDL

    Directory of Open Access Journals (Sweden)

    Emy Yuliantini

    2016-09-01

    Full Text Available Perubahan pola hidup menyebabkan pola penyakit berubah, dari penyakit infeksi dan rawan gizi ke penyakit-penyakit  degeneratif, diantaranya adalah penyakit jantung dan pembuluh darah (kardiovaskuler dan akibat kematian yang ditimbulkannya. Penyakit jantung merupakan penyebab kematian nomor satu di dunia. Penyakit jantung adalah penyakit yang mengganggu sistem pembuluh darah atau lebih tepatnya menyerang jantung dan urat-urat darah. Penyakit kardiovaskuler (PKV mempunyai hubungan yang erat dengan zat gizi dan makanan. Hipotesis “makanan-jantung“ atau diet-heart hypothesis menerangkan bahwa adanya hubungan antara makanan dengan penyakit jantung. Tujuan penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan rasio kadar kolesterol total/HDL. Desain penelitian ini adalah potong lintang/cross sectional dengan variabel independen (asupan energi, asupan lemak jenuh, lemak tak jenuh, kolesterol dan serat dan variabel dependen (rasio kadar kolesterol total/HDL. Jumlah populasi 760 dan sampel sebanyak 45 responden. Sampel penelitian diambil secara accidental sampling. Hasil penelitian menunjukkan bahwa ada hubungan yang bermakna antara asupan energi, lemak jenuh, lemak tak jenuh dan kolesterol dengan rasio kadar kolesterol total/HDL. Tidak ada hubungan yang bermakna antar asupan serat dengan rasio kadar kolesterol total/HDL. Faktor yang paling berhubungan adalah asupan lemak jenuh.

  12. Kinetics of HDL cholesterol and paraoxonase activity in moderate alcohol consumers

    NARCIS (Netherlands)

    Sierksma, A.; Gaag, M.S. van der; Tol, A. van; James, R.W.; Hendriks, H.F.J.

    2002-01-01

    Background: The inverse association between moderate drinking and coronary heart disease mortality is well established. This study was performed to investigate the kinetics of the alcohol-induced increases in apo A-1, HDL cholesterol, and paraoxonase (PON) activity, as well as to study whether the

  13. Hardware Reuse Improvement through the Domain Specific Language dHDL.

    OpenAIRE

    Sánchez Marcos, Miguel Ángel; López Vallejo, Marisa; Iglesias Fernandez, Carlos Angel

    2012-01-01

    The dHDL language has been defined to improve hardware design productivity. This is achieved through the definition of a better reuse interface (including parameters, attributes and macroports) and the creation of control structures that help the designer in the hardware generation process.

  14. Clinical and biological relevance of statin-mediated changes in HDL metabolism

    NARCIS (Netherlands)

    Arsenault, Benoit J.; Boekholdt, S. Matthijs

    2014-01-01

    Although prospective studies consistently show that individuals with low levels of high-density lipoprotein (HDL) cholesterol are at increased cardiovascular risk, it is still not clear whether or not this relationship still holds in patients treated with statins who have achieved optimal

  15. Egg intake improves carotenoid status by increasing plasma HDL cholesterol in adults with metabolic syndrome.

    Science.gov (United States)

    Blesso, Christopher N; Andersen, Catherine J; Bolling, Bradley W; Fernandez, Maria Luz

    2013-02-01

    Metabolic syndrome (MetS) is associated with reductions in plasma lutein and zeaxanthin, along with altered composition of their lipoprotein transporters which may affect disease risk. Egg yolk intake has been demonstrated to increase plasma lutein and zeaxanthin in other populations. The objective of this study was to investigate the effects of whole egg feeding on plasma and lipoprotein carotenoids in participants with MetS. Participants consumed 3 whole eggs per day (EGG, n = 20) or the equivalent amount of yolk-free egg substitute (SUB, n = 17), as part of a carbohydrate-restricted diet (CRD) for 12 weeks. Post-intervention, the EGG group had significant increases in plasma lutein (+21%), zeaxanthin (+48%), and β-carotene (+24%), while the SUB group had increases in plasma β-carotene (+55%) only. Significant enrichment of isolated HDL and LDL fractions in lutein (+20% HDL, +9% LDL) and zeaxanthin (+57% HDL, +46% LDL) was observed in the EGG group after 12 weeks. Increases in the proportion of plasma carotenoids carried by HDL was seen for lutein (P eggs, as part of a CRD, increased both plasma and lipoprotein lutein and zeaxanthin. Egg yolk may represent an important food source to improve plasma carotenoid status in a population at high risk for cardiovascular disease and type 2 diabetes.

  16. Human paraoxonase and HDL-cholesterol in pakistan patients with acute myocardial infarction and normal healthy adults

    International Nuclear Information System (INIS)

    Iqbal, I.P.; Khan, A.H.; Mehboobali, N.

    2007-01-01

    Human serum paraoxonase is a high density lipoprotein (HDL)-bound enzyme exhibiting antiatherogenic properties. The aim of this study was to investigate any relationship between serum paraoxonase activity and serum levels of HDL-cholesterol in Pakistani patients with acute myocardial infarction (AMI) compared to normal healthy subjects and to examine possible association between serum paraoxonase activity and AMI in Pakistani population. In a case-control study, serum paraoxonase activity and serum levels of HDL-cholesterol and LDL-cholesterol were monitored in 164 Pakistani patients with AMI and 106 normal healthy adults matched for gender, BMI and age within 10 years. Mean serum concentration of HDL-cholesterol and mean serum paraoxonase activity in AMI patients were not significantly different from the corresponding values in normal healthy subjects. Mean serum paraoxonase activity value was significantly lower in normal healthy subjects with low HDL-cholesterol (serum levels < 40mg/dl) compared to the value in those with normal levels of HDL-cholesterol (P=0.04). In AMI patients, paraoxonase activity was lower in subjects with low HDL-cholesterol compared to those with normal levels of HDL-cholesterol, however, the decrease was not statistically significant. Correlation analyses of the data revealed a moderate association of paraoxonase activity with HDL-cholesterol (Pearson's r= 0.225, P<0.01 for AMI patients and r=0.281, P<0.01 for normal healthy controls). Seventy three percent of normal healthy subjects and 65% of AMI patients in this study had low HDL-cholesterol. Low serum paraoxonase activity and high prevalence of low HDL-cholesterol in Pakistani population could be contributing to the high rates of coronary heart disease in this population. (author)

  17. Caracterización morfométrica de la cuenca alta del río Sauce Grande.

    Directory of Open Access Journals (Sweden)

    Fernanda Julia Gaspari

    2013-01-01

    Full Text Available La cuenca alta del río Sauce Grande abastece el complejo hidráulico Embalse Paso de las Piedras, comportándose como servicio ambiental primordial para el consumo hídrico de Bahía Blanca. El análisis de las características morfométricas y funcionales de una cuenca hidrográfica a través de parámetros de forma, relieve y red de drenaje, es básico en la modelación hidrológica para determinar el movimiento y captación del agua de lluvia. Estos indicadores pueden apoyar una formulación de un Sistema de Pago por Servicios Ambientales, como estrategia básica de ordenamiento territorial y desarrollo local, centrado en la oferta de agua generada por la cuenca. El objetivo fue caracterizar morfométricamente la cuenca alta del río Sauce Grande. La metodología aplicada se basó en establecer y analizar los parámetros morfométricos mediante el uso de Sistemas de Información Geográfica y planillas de cálculo, a partir de un modelo digital del terreno e imágenes satelitales. Los resultados alcanzados definieron que la cuenca posee un área de 1502.6 km2. La longitud axial es de 41.6 km con un ancho promedio de 36.1 km. El Factor de forma (0.87 indica que posee forma alargada, siendo rectangular oblonga según el coeficiente de compacidad de Gravelius (2.8. La longitud del cauce principal es 58.34 km con pendiente media de 0.48 %. La densidad de drenaje es 0.27 km.km-2 y su coeficiente de sinuosidad 1.42. El tiempo de concentración es 11.8 hs. La curva hipsométrica adimensional corresponde a una cuenca con un avanzado grado de desarrollo. Todos estos parámetros facilitan la cuantificación del caudal líquido en la cuenca.

  18. Oxidative profiles of LDL and HDL isolated from women with preeclampsia.

    Science.gov (United States)

    León-Reyes, G; Maida-Claros, R F; Urrutia-Medina, A X; Jorge-Galarza, E; Guzmán-Grenfell, A M; Fuentes-García, S; Medina-Navarro, R; Moreno-Eutimio, M A; Muñoz-Sánchez, J L; Hicks, J J; Torres-Ramos, Y D

    2017-05-16

    Oxidative stress causes biochemical changes in lipids and proteins; these changes can induce damage to the vascular endothelium and create maternal complications that are characteristic of preeclampsia. In this study, we evaluated the oxidative profile of lipoproteins isolated from women with preeclampsia. Thirty women diagnosed with preeclampsia and thirty women without preeclampsia were included in the study. Lipid-damage biomarkers, including conjugated dienes, lipohydroperoxides and malondialdehyde, were measured. The reduction of nitroblue tetrazolium, the formation of dityrosines, and the carbonylation of proteins were assessed as indicators of protein damage. The protective activity of HDL-c was evaluated by the paraoxonase-I activity present on the HDL-c particles. Serum lipid profiles were also quantified in both groups. Data were analysed using Student's t test and the Pearson correlation coefficient. Our results demonstrated in PE women evident oxidative changes in the lipids and proteins in HDL-c and LDL-c particles and the activity of the antioxidant enzyme PON-I decreased 59.9%. HDL-c exhibited self-defence, as demonstrated by the negative correlation between paraoxonase-I activity and the formation of lipohydroperoxides in HDL-c (r = -0.3755, p preeclampsia show oxidative damage to lipids and proteins. We propose an oxidative profile based on the oxidation levels indicated by each of the markers used. We also found that paraoxonase-I is inactivated in the presence of lipohydroperoxides. Antioxidant support might be helpful to reduce oxidative stress in patients with preeclampsia. Further investigations are necessary to define the association between antioxidant activities and preeclampsia.

  19. Postpartum weight retention is associated with elevated ratio of oxidized LDL lipids to HDL-cholesterol.

    Science.gov (United States)

    Puhkala, Jatta; Luoto, Riitta; Ahotupa, Markku; Raitanen, Jani; Vasankari, Tommi

    2013-12-01

    Oxidized LDL lipids (ox-LDL) are associated with lifestyle diseases such as cardiovascular diseases, metabolic syndrome and type 2 diabetes. The present study investigated how postpartum weight retention effects on ox-LDL and serum lipids. The study is a nested comparative research of a cluster-randomized controlled trial, NELLI (lifestyle and counselling during pregnancy). During early pregnancy (8-12 weeks) and 1 year postpartum, 141 women participated in measurements for determining of plasma lipids: total cholesterol (T-C), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triacylglycerols (TAG) and ox-LDL. Subjects were stratified into tertiles (weight loss, unaltered weight and weight gain groups) based on their weight change from baseline to follow-up. Ox-LDL was determined by baseline level of conjugated dienes in LDL lipids. Among the group of weight gainers, concentration of TAG reduced less (-0.14 vs. -0.33, p = 0.002), HDL-C reduced more (-0.31 vs. -0.16, p = 0.003) and ox-LDL/HDL-C ratio increased (3.0 vs. -0.2, p = 0.003) when compared to group of weight loss. Both T-C and LDL-C elevated more (0.14 vs. -0.21, p = 0.008; 0.31 vs. 0.07, p = 0.015) and TAG and ox-LDL reduced less (-0.33 vs. 0.20, p = 0.033; -3.33 vs. -0.68, p = 0.026) in unaltered weight group compared to weight loss group. The women who gained weight developed higher TAG and ox-LDL/HDL-C ratio as compared to those who lost weight. Postpartum weight retention of 3.4 kg or more is associated with atherogenic lipid profile.

  20. Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR study.

    Directory of Open Access Journals (Sweden)

    Caitrin W McDonough

    Full Text Available We sought to identify novel pharmacogenomic markers for HDL-C response to atenolol in participants with mild to moderate hypertension. We genotyped 768 hypertensive participants from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR study on the Illumina HumanCVD Beadchip. During PEAR, participants were randomized to receive atenolol or hydrochlorothiazide. Blood pressure and cholesterol levels were evaluated at baseline and after treatment. This study focused on participants treated with atenolol monotherapy. Association with atenolol induced HDL-C change was evaluated in 232 whites and 152 African Americans using linear regression. No SNPs achieved a Bonferroni corrected P-value. However, we identified 13 regions with consistent association across whites and African Americans. The most interesting of these regions were seven with prior associations with HDL-C, other metabolic traits, or functional implications in the lipid pathway: GALNT2, FTO, ABCB1, LRP5, STARD3NL, ESR1, and LIPC. Examples are rs2144300 in GALNT2 in whites (P=2.29x10(-4, β=-1.85 mg/dL and rs12595985 in FTO in African Americans (P=2.90x10(-4, β=4.52 mg/dL, both with consistent regional association (P<0.05 in the other race group. Additionally, baseline GALNT2 expression differed by rs2144300 genotype in whites (P=0.0279. In conclusion, we identified multiple gene regions associated with atenolol induced HDL-C change that were consistent across race groups, several with functional implications or prior associations with HDL-C.

  1. Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels

    Directory of Open Access Journals (Sweden)

    Hinds David A

    2004-11-01

    Full Text Available Abstract Association studies are used to identify genetic determinants of complex human traits of medical interest. With the large number of validated single nucleotide polymorphisms (SNPs currently available, two limiting factors in association studies are genotyping capability and costs. Pooled DNA genotyping has been proposed as an efficient means of screening SNPs for allele frequency differences in case-control studies and for prioritising them for subsequent individual genotyping analysis. Here, we apply quantitative pooled genotyping followed by individual genotyping and replication to identify associations with human serum high-density lipoprotein (HDL cholesterol levels. The DNA from individuals with low and high HDL cholesterol levels was pooled separately, each pool was amplified by polymerase chain reaction in triplicate and each amplified product was separately hybridised to a high-density oligonucleotide array. Allele frequency differences between case and control groups with low and high HDL cholesterol levels were estimated for 7,283 SNPs distributed across 71 candidate gene regions spanning a total of 17.1 megabases. A novel method was developed to take advantage of independently derived haplotype map information to improve the pooled estimates of allele frequency differences. A subset of SNPs with the largest estimated allele frequency differences between low and high HDL cholesterol groups was chosen for individual genotyping in the study population, as well as in a separate replication population. Four SNPs in a single haplotype block within the cholesteryl ester transfer protein (CETP gene interval were significantly associated with HDL cholesterol levels in both populations. Our study is among the first to demonstrate the application of pooled genotyping followed by confirmation with individual genotyping to identify genetic determinants of a complex trait.

  2. Increased inflammatory effect of electronegative LDL and decreased protection by HDL in type 2 diabetic patients.

    Science.gov (United States)

    Estruch, Montserrat; Miñambres, Inka; Sanchez-Quesada, Jose Luis; Soler, Marta; Pérez, Antonio; Ordoñez-Llanos, Jordi; Benitez, Sonia

    2017-10-01

    Type 2 diabetic patients have an increased proportion of electronegative low-density lipoprotein (LDL(-)), an inflammatory LDL subfraction present in blood, and dysfunctional high-density lipoprotein (HDL). We aimed at examining the inflammatory effect of LDL(-) on monocytes and the counteracting effect of HDL in the context of type 2 diabetes. This was a cross-sectional study in which the population comprised 3 groups (n = 12 in each group): type 2 diabetic patients with good glycaemic control (GC-T2DM patients), type 2 diabetic patients with poor glycaemic control (PC-T2DM), and a control group. Total LDL, HDL, and monocytes were isolated from plasma of these subjects. LDL(-) was isolated from total LDL by anion-exchange chromatography. LDL(-) from the three groups of subjects was added to monocytes in the presence or absence of HDL, and cytokines released by monocytes were quantified by ELISA. LDL(-) proportion and plasma inflammatory markers were increased in PC-T2DM patients. LDL(-) from PC-T2DM patients induced the highest IL1β, IL6, and IL10 release in monocytes compared to LDL(-) from GC-T2DM and healthy subjects, and presented the highest content of non-esterified fatty acids (NEFA). In turn, HDL from PC-T2DM patients showed the lowest ability to inhibit LDL(-)-induced cytokine release in parallel to an impaired ability to decrease NEFA content in LDL(-). Our findings show an imbalance in the pro- and anti-inflammatory effects of lipoproteins from T2DM patients, particularly in PC-T2DM. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase

    NARCIS (Netherlands)

    Simic, B.; Mocharla, P.; Crucet, M.; Osto, E.; Kratzer, A.; Stivala, S.; Kühnast, S.; Speet, T.; Doycheva, P.; Princen, H.M.G.; Hoorn, J.W.A. van der; Jukema, J.W.; Giral, H.; Tailleux, A.; Landmesser, U.; Syaels, B.; Lüscher, T.F.

    2017-01-01

    Background and aims. High-density lipoprotein cholesterol (HDL-C) is inversely related to cardiovascular risk. HDL-C raising ester transfer protein (CETP) inhibitors, are novel therapeutics. We studied the effects of CETP inhibitors anacetrapib and evacetrapib on triglycerides, cholesterol and

  4. Nonlinear dynamics of early atherosclerotic plaque formation may determine the efficacy of high density lipoproteins (HDL in plaque regression.

    Directory of Open Access Journals (Sweden)

    Alexander D Chalmers

    Full Text Available We use a computational model to explore the effect of foam cell accumulation on plaque regression following an increase in high density lipoprotein (HDL influx into the plaque. Atherosclerotic plaque formation is the outcome of cellular and cytokine responses to low density lipoproteins (LDL that penetrate the artery wall following an injury to the endothelium and become modified. We modelled the cells and cytokines that are most important in plaque formation using partial differential equations. The model includes monocytes and macrophages, foam cells, macrophage chemoattractants, endothelium-stimulating cytokines, modified low density lipoproteins (mod LDL and HDL. We included interactions both at the endothelium surface and inside the artery wall. The model predicts that when HDL influx into a well-established plaque with large numbers of foam cells is increased, the plaque may not regress but may continue to grow at a slower rate. If HDL influx is increased when a model plaque is recently established and has fewer foam cells, then the plaque does regress. If modLDL influx into the plaque is lowered at the same time that HDL influx increased or the capacity of the HDL to remove cholesterol from foam cells is increased, then the plaque is more likely to regress. The predictions of the model are in qualitative agreement with experimental studies in mice and rabbits. The results suggest that the intrinsic dynamics of reverse cholesterol transport by HDL are important in determining the success of HDL raising in promoting plaque regression.

  5. Native High Density Lipoproteins (HDL Interfere with Platelet Activation Induced by Oxidized Low Density Lipoproteins (OxLDL

    Directory of Open Access Journals (Sweden)

    Ivo Volf

    2013-05-01

    Full Text Available Platelets and lipoproteins play a crucial role in atherogenesis, in part by their ability to modulate inflammation and oxidative stress. While oxidized low density lipoproteins (OxLDL play a central role in the development of this disease, high density lipoproteins (HDL represent an atheroprotective factor of utmost importance. As platelet function is remarkably sensitive to the influence of plasma lipoproteins, it was the aim of this study to clarify if HDL are able to counteract the stimulating effects of OxLDL with special emphasis on aspects of platelet function that are relevant to inflammation. Therefore, HDL were tested for their ability to interfere with pro-thrombotic and pro-inflammatory aspects of platelet function. We are able to show that HDL significantly impaired OxLDL-induced platelet aggregation and adhesion. In gel-filtered platelets, HDL decreased both the formation of reactive oxygen species and CD40L expression. Furthermore, HDL strongly interfered with OxLDL-induced formation of platelet-neutrophil aggregates in whole blood, suggesting that platelets represent a relevant and sensitive target for HDL. The finding that HDL effectively competed with the binding of OxLDL to the platelet surface might contribute to their atheroprotective and antithrombotic properties.

  6. Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    Haan, W. de; Hoogt, C.C. van der; Westerterp, M.; Hoekstra, M.; Dallinga-Thie, G.M.; Princen, H.M.G.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Rensen, P.C.N.

    2008-01-01

    Objective: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity. Our aim was to determine whether the increase in HDL depends on CETP

  7. Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    de Haan, Willeke; van der Hoogt, Caroline C.; Westerterp, Marit; Hoekstra, Menno; Dallinga-Thie, Geesje M.; Princen, Hans M. G.; Romijn, Johannes A.; Jukema, J. Wouter; Havekes, Louis M.; Rensen, Patrick C. N.

    2008-01-01

    OBJECTIVE: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity. Our aim was to determine whether the increase in HDL depends on CETP

  8. TransForm: TransAlta 2000 annual report

    International Nuclear Information System (INIS)

    2001-01-01

    Financial information from TransAlta Corp. was presented along with a review of their operations throughout 2000 and a summary of the how the electric utility is doing in terms of power generation, independent power producers, transmission and energy marketing. The utility has changed from a regulated vertically integrated utility into one of Canada's largest non-regulated electric power generators. The utility sold its retail businesses in Alberta and New Zealand and now focuses on coal and hydro generation, gas generation, high-voltage transmission and energy marketing. The newly constructed Centralia, Washington generation facility was brought on line with 1,340 MW in May 2000, on time and on budget. This was the platform to diversify their generation into the United States. The utility reported a solid financial year with $177.9 million in earnings from continuing operations, an 83 per cent increase from 1999, driven mostly by the results of Centralia and power marketing and trading businesses. A financial loss was suffered when the Wabamum power plant in Alberta was shut down for several months to repair a boiler. The utility made excellent progress toward their goal of 15,000 megawatts by 2005 by starting with the construction of what will be one of Canada's largest cogeneration facilities at Sarnia, Ontario. TransAlta also commissioned a 360 MW cogeneration facility at Poplar Creek at Suncor's Fort McMurray oil sand facility. TransAlta also has an excellent track record in developing power generation projects internationally. refs., tabs., figs

  9. COMPORTAMIENTO DEL METABOLISMO LIPÍDICO EN PACIENTES CON VIH/SIDA DE BOGOTÁ

    OpenAIRE

    Guerra, Martha; Departamento de Bioquímica y Nutrición Facultad de Ciencias Pontificia Universidad Javeriana, Bogotá; Alvarado, M.; Departamento de Matemáticas Facultad de Ciencias Pontificia Universidad Javeriana, Bogotá; Fonseca, V. L.; Departamento de Bioquímica y Nutrición Facultad de Ciencias Pontificia Universidad Javeriana, Bogotá; Valbuena, V.; Departamento de Bioquímica y Nutrición Facultad de Ciencias Pontificia Universidad Javeriana, Bogotá

    2007-01-01

    El propósito del estudio fue comparar algunos parámetros del perfil lipídico: colesterol total, triglicéridos, lipoproteínas de baja densidad (LDL: Low-density Lipoprotein), lipoproteínas de muy baja densidad (VLDL: Very low-density Lipoprotein), lipoproteínas de alta densidad (HDL: High-density lipoprotein) y las apoproteínas A-I y B100, en 30 pacientes adultos diagnosticados con VIH/SIDA sin terapia retroviral previa, y en 30 individuos saludables seleccionados de la consulta externa del Ho...

  10. Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes

    DEFF Research Database (Denmark)

    Siebel, Andrew L; Trinh, Si Khiang; Formosa, Melissa F

    2016-01-01

    AIMS: High-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I) can modulate glucose metabolism through multiple mechanisms. This study determined the effects of a novel bromodomain and extra-terminal (BET) inhibitor (RVX-208) and putative apoA-I inducer on lipid species contained within HDL...... (HDL lipidome) and glucose metabolism. MATERIALS AND METHODS: Twenty unmedicated males with prediabetes received 100mg b.i.d. RVX-208 and placebo for 29-33days separated by a wash-out period in a randomized, cross-over design trial. Plasma HDL-cholesterol and apoA-I were assessed as well as lipoprotein...... particle size and distribution using NMR spectroscopy. An oral glucose tolerance test (OGTT) protocol with oral and infused stable isotope tracers was employed to assess postprandial plasma glucose, indices of insulin secretion and insulin sensitivity, glucose kinetics and lipolysis. Whole plasma and HDL...

  11. Vulnerabilidad en la cuenca alta del rio Lerma

    OpenAIRE

    Cedeño Valdiviezo, Alberto; Torres Lima, Pablo

    2013-01-01

    La subcuenca Alta del Río Lerma en el Estado de México, importante abastecedor de agua para la Ciudad de México, ha estado expuesta a una fuerte contaminación en los últimos años, misma que ha tenido como consecuencia el Cambio Climático y los consecuentes problemas de salud pública que se están manifestando de diferentes maneras. No obstante, el Estado Mexicano insiste en seguir apoyando a empresas trasnacionales asociadas al cultivo de transgénicos, producción de plaguicidas, pesticidas y P...

  12. Estructura y densidad de la red de caminos en la Reserva de la Biosfera Mariposa Monarca

    Directory of Open Access Journals (Sweden)

    María Isabel Ramírez Ramírez

    2012-02-01

    Full Text Available Por ser parte fundamental de uno de los fenómenos de migración e hibernación más sorprendentes y llamativos del mundo, la Reserva de la Biosfera Mariposa Monarca (RBMM se ha convertido en una de las áreas naturales protegidas más emblemáticas de nuestro país. Sin embargo, sigue enfrentándose a serios problemas de fragmentación, perturbación y pérdida de sus bosques. Uno de los elementos del paisaje que más se ha reconocido como causa y efecto de la perturbación y pérdida de espacios forestales son los caminos. Utilizando mosaicos elaborados con fotografías aéreas digitales de marzo de 2003, escala 1:20 000, y recorridos en campo registrados con GPS, se identificaron 20 574 km de caminos dentro de los límites de la RBMM; 55% del ellos son brechas y 37% veredas, ambos abiertos específicamente para el aprovechamiento forestal. Las carreteras pavimentadas y las terracerías representan, respectivamente, 2 y 6% de la red. Esos 2 574 km de caminos se traducen en una densidad promedio de 4.7 km/km2. No obstante, el análisis a nivel de predio revela valores de densidad aún más altos, especialmente en el lado michoacano, que alcanzan hasta 13.6 km/km2. Asimismo, multiplicando los respectivos tipos de caminos por su ancho promedio de lecho, se encontró que 880 ha de la Reserva están ocupadas por caminos, lo cual tiene serias repercusiones sobre la vegetación, el suelo, la red de drenaje y la accesibilidad a los recursos.

  13. EFECTO DE LA DENSIDAD DE PLANTACIÓN EN LA RENTABILIDAD DE PLANTACIONES DE Eucalyptus globulus

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    Emilio Guerra-Bugueño

    2014-01-01

    Full Text Available El estudio evaluó, económicamente, la respuesta de densidades de plantación y marcos de espaciamiento de Eucalyptus globulus establecido con fines pulpables. La técnica de Montecarlo se usó para examinar el efecto de las variaciones de precios y la tasa de descuento sobre la rentabilidad. El ensayo fue realizado en el Valle Central de la IX Región de Chile. Los tratamientos fueron: 1,000 árboles·ha-1(T1; 1,428 árboles·ha-1 (T2; 1,667 árboles·ha-1 (T3 y 2,000 árboles·ha-1 (T4. El volumen de producción de cada tratamiento se midió a la edad de cosecha (10 años y posteriormente se realizó un análisis financiero, para obtener la rentabilidad (valor actual neto [VAN], valor económico del suelo [VES] y tasa interna de retorno [TIR]. Los mayores valores de VAN se obtuvieron con el T1 (US$ 330·ha-1 y T4 (US$ 322·ha-1. Los pronósticos obtenidos para el VAN de T1 mostraron una probabilidad de ocurrencia de 73 %, resultando ser la opción menos riesgosa para la inversión. Los mayores rendimientos volumétricos (T4 y T3 no propician las mayores rentabilidades, pues el incremento de la densidad de plantación aumenta los costos por unidad de planta con relación al manejo de suelos, control de malezas y fertilización.

  14. Densidad mineral ósea en una muestra de jóvenes chilenos practicantes de diversas modalidades deportivas

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    Rossana Gómez-Campos

    2017-01-01

    Full Text Available Objetivos: Objetivos: a Comparar la densidad mineral ósea de una muestra de jóvenes chilenos practicantes de diversas modalidades deportivas y b Analizar la densidad mineral ósea en función de la maduración biológica. Métodos: Se estudiaron 146 adolescentes de sexo masculino, con un rango de edad entre 10 a 18 años. Se organizaron cinco grupos de trabajo: Grupo control (escolares n= 40, Canotaje (n= 30, Ciclismo (n=14, Fútbol (n=28 y Natación (n=34. Se evaluó el peso, estatura, altura tronco-cefálica. Se calculó el índice de Masa Corporal y la maduración biológica por medio de años de pico de velocidad de crecimiento. La densidad mineral ósea de cuerpo total y el porcentaje de grasa corporal se determinó por medio de la absorciometría de rayos X de doble energía. Resultados: Los adolescentes que practicaban fútbol evidenciaron mayor densidad mineral ósea (1,23±0,12g/cm 2 en relación a los jóvenes del ciclismo (0,99±0,11g/cm 2 , canotaje (1,09±0,17g/cm 2 , natación (1,10±0,11g/cm 2 y al grupo control de escolares (1,04±0,14g/ cm 2 (p<0.001. Hubo diferencias entre los tres niveles de maduración biológica en las cuatro modalidades deportivas y en el grupo control (p<0.001. La mayor densidad mineral ósea en función de la maduración somática se observó en los futbolistas. Conclusión: Los adolescentes que practican fútbol evidenciaron mayor densidad mineral ósea con relación a las demás modalidades deportivas y con relación al grupo control, además la maduración somática juega un papel relevante en el incremento de densidad mineral ósea, en especial en los futbolistas. Los resultados sugieren desarrollar actividades físico- deportivas de alto impacto antes, durante y después de producirse la maduración biológica en adolescentes de edad escolar.

  15. EFECTO DEL RALEO SOBRE EL CRECIMIENTO Y LA DENSIDAD DE LA MADERA DE Pinus taeda IMPLANTADO EN MISIONES, ARGENTINA

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    Rodolfo Martiarena

    2014-01-01

    Full Text Available El mayor incremento en crecimiento de la plantación puede causar variación en las propiedades físicas de la madera, pudiendo disminuir la calidad de la misma para la industria. El objetivo del presente trabajo es evaluar el efecto de los tratamientos de raleo sobre el crecimiento y densidad de la madera de Pinus taeda implantado en Misiones, Argentina (25º 59’S - 54º24’O. La plantación se estableció en 1985 con densidad inicial de 1644 pl.ha -1 y se manejó con tres intensidades de raleo (0, 33 y 66 % del área basal del testigo sin ralear, bajo un diseño de bloques completos al azar (3 bloques. A los 20 años se efectuó tala rasa, cuyas densidades eran 711 (0 %, 364 (33 % y 122 (66 % plantas por hectárea, momento en el cual se seleccionaron 45 árboles para determinar la densidad básica de la madera. La misma se determinó a través de la realización de 2.700 probetas. El crecimiento de la plantación fue afectado por la intensidad de raleo, registrando diámetros promedio de 28,7, 34,8 y 45,9 cm, respectivamente, en los tratamientos 0, 33 y 66 % de raleo. El volumen de la plantación, al momento del apeo, fue superior en el tratamiento sin raleo, no obstante el tratamiento 66 % de raleo generó mayor cantidad de madera de grandes dimensiones. La densidad básica como promedio simple y ponderado por volumen no presentó diferencias significativas entre tratamientos. Los valores de densidad ponderada fueron de 0,406, 0,418 y 0,420 g.cm -3 para los tratamientos 0, 33 y 66 % de raleo, respectivamente, mientras que el análisis de correlación entre diámetro y densidad no fue significativo. El estudio mostró que la intensidad de raleo puede ser manejada para maximizar la producción, manteniendo idéntica la calidad de la madera para la industria.

  16. Altas tecnologías, conflictos armados y seguridad humana

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    Elena del Mar García Rico

    2016-01-01

    Full Text Available El examen de las amenazas para la seguridad y el bienestar de las personas inherentes al concepto de seguridad humana exige ocuparse también de las consecuencias que la utilización de las altas tecnologías puedan ocasionar en relación con los conflictos armados actuales. De ahí que en este trabajo abordemos los cambios relevantes en la naturaleza y características de los nuevos conflictos armados provocados por la celeridad y amplitud en el empleo de altas tecnologías y su desigual distribución entre los beligerantes, tal y como muestran las llamadas guerras de coste cero, de cuarta generación o asimétricas, e incluso las híbridas. Asimismo, el desarrollo reciente de las capacidades militares cibernéticas, de los sistemas de armas autónomos y de los vehículos aéreos no tripulados plantea nuevos retos al Derecho Internacional Humanitario, aspectos contemplados en este estudio.

  17. AGRICULTURA SOSTENIBLE EN ECOSISTEMAS DE ALTA MONTAÑA

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    DIANA MARCELA RUIZ O

    Full Text Available La agricultura como principal actividad del desarrollo económico rural en Colombia ha sido implementada con diferentes estrategias desde la época precolombina. Los ecosistemas de la alta montaña no han sido ajenos a esta realidad, y particularmente en las zonas de Páramo del Cauca, el intento por favorecer la prevalencia de un modelo altamente productivo e intensivo en el uso del suelo ha conllevado al detrimento de la diversidad socio-ecológica, la rápida expansión de la frontera agropecuaria en áreas estratégicas, la pérdida del conocimiento tradicional sobre el uso de la tierra y el bajo rendimiento de los cultivos que ha implicado mayor incorporación de fertilizantes al suelo amenazando estos sistemas vulnerables en la alta montaña. Sin embargo, es común encontrar en diferentes localidades paramunas caucanas comunidades indígenas y campesinas que reconocen la necesidad de cambiar los sistemas productivos que han venido empleando debido a la disminución de la fertilidad del suelo que limita la comercialización de sus productos y a la problemática ambiental asociada, en este sentido, el acompañamiento institucional en este proceso es vital para favorecer la implementación de procesos sostenibles de forma integral.

  18. Technology for Salt Production in the Mixteca Alta

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    Ricardo Antonio León Hernández

    2015-01-01

    Full Text Available Salt production in the Mixteca Alta is a traditional means of production from prehispanic period, which, despite the economic transformation processes in the colonial period, remained significant features of the traditional process, based on the documented similar models from other productive regions in Mexico. The salt in the novohispanic period was considered a major consumption economic asset due to its use in production processes for the production of new economic products that supported the economy of preindustrial societies (Terán, 2011, p. 71; Williams, 2008. Technology refers to the knowledges for solving human needs arising lifestyle of the cultural groups that develop them. The resources of the natural environment underpin the means of labor that man requires to perform its activities, including economic. The means of production and production processes are technological developments, which involve elements of tangible and intangible order. The study of work processes for salt extraction, are significantly related to the processes of technological evolution that man has developed for the use of natural resources. The economic activities of the primary sector are examples of how humans culturally and economically were inserted in the natural environment (Malpica, 2008, p. 59. This analysis presents a historiographical approach to the study of the processes and the technology required for the extraction of salt in the Mixteca Alta.

  19. Comparison of non-HDL-cholesterol versus triglycerides-to-HDL-cholesterol ratio in relation to cardiometabolic risk factors and preclinical organ damage in overweight/obese children: the CARITALY study.

    Science.gov (United States)

    Di Bonito, P; Valerio, G; Grugni, G; Licenziati, M R; Maffeis, C; Manco, M; Miraglia del Giudice, E; Pacifico, L; Pellegrin, M C; Tomat, M; Baroni, M G

    2015-05-01

    Lipid ratios to estimate atherosclerotic disease risk in overweight/obese children are receiving great attention. We aimed to compare the performance of non-high-density lipoprotein-cholesterol (HDL-C) versus triglycerides-to-HDL-C ratio (Tg/HDL-C) in identifying cardiometabolic risk factors (CMRFs) or preclinical signs of organ damage in outpatient Italian overweight/obese children. In this retrospective, cross-sectional study, 5505 children (age 5-18 years) were recruited from 10 Italian centers for the care of obesity, of which 4417 (78%) showed obesity or morbid obesity. Anthropometric, biochemical, and blood pressure variables were analyzed in all children. Liver ultrasound scan, carotid artery ultrasound, and echocardiography were performed in 1257, 601, and 252 children, respectively. The entire cohort was divided based on the 75th percentile of non-HDL-C (≥130 mg/dl) or Tg/HDL-C ratio (≥2.2). The odds ratio for insulin resistance, high blood pressure, metabolic syndrome, presence of liver steatosis, increased levels of carotid intima-media thickness (cIMT) and concentric left ventricular hypertrophy (cLVH) was higher in children with high levels of Tg/HDL-C with respect to children with high levels of non-HDL-C. In an outpatient setting of overweight/obese children, Tg/HDL-C ratio discriminated better than non-HDL-C children with CMRFs or preclinical signs of liver steatosis, and increased cIMT and cLVH. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess.

    Science.gov (United States)

    Samino, Sara; Vinaixa, Maria; Díaz, Marta; Beltran, Antoni; Rodríguez, Miguel A; Mallol, Roger; Heras, Mercedes; Cabre, Anna; Garcia, Lorena; Canela, Nuria; de Zegher, Francis; Correig, Xavier; Ibáñez, Lourdes; Yanes, Oscar

    2015-06-23

    Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide.

  1. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

    OpenAIRE

    Voight, Benjamin F; Peloso, Gina M; Orho-Melander, Marju; Frikke-Schmidt, Ruth; Barbalic, Maja; Jensen, Majken K; Hindy, George; Hólm, Hilma; Ding, Eric L; Johnson, Toby; Schunkert, Heribert; Samani, Nilesh J; Clarke, Robert; Hopewell, Jemma C; Thompson, John F

    2012-01-01

    Summary Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. Methods We performed two mendelian randomisation analyses. Fi...

  2. Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients

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    Muzaffer Eroglu

    2013-07-01

    Full Text Available Increases in the generation of reactive oxygen species and decreases in antioxidant enzyme activities with aging have been reported in the prostate, and are also observed in age-related disorders such as atherosclerosis, Alzheimer's disease, and cataracts. Several studies have demonstrated that proteins are targets for reactive oxidants in cells, and that oxidized proteins accumulate during aging, oxidative stress and in some pathological conditions. However, only a limited number of studies have actually evaluated oxidative damage in relation to HDL-cholesterol-associated antioxidant enzyme activities or have assessed its relationship with prostate cancer. In this study, we examined the effect of HDL-cholesterol-associated antioxidant enzyme activities, paraoxonase1, arylesterase and new oxidative stress parameters (total oxidant status, total antioxidant status [and oxidative stress index] in newly-diagnosed prostate cancer patients and healthy controls. There were no significant differences in oxidative stress parameters and lipid parameters between prostate cancer patients and controls, however, paraoxonase1 enzyme activity, and non-HDL-cholesterol levels were higher in prostate cancer patients than controls. The results of this study were derived from a small number of subjects, but might represent an important working hypothesis for further research in a larger number of cases to clarify the role of paraoxonase1 overproduction on the prostate and its clinical relevance.

  3. Is the Monocyte/HDL Ratio a Prognostic Marker of Idiopathic Sudden Hearing Loss?

    Science.gov (United States)

    Koçak, Hasan Emre; Acipayam, Harun; Elbistanlı, Mustafa Suphi; Yiğider, Ayşe Pelin; Alakhras, Wesam; Kıral, Mehmet Nurettin; Kayhan, Fatma Tülin

    2016-10-31

    In this study, our aim was to investigate whether Monocyte/HDL ratio is a marker of the prognosis of the idiopathic sudden hearing loss (ISHL). Retrospective, case-control clinical trial. 45 patients, who were diagnosed with idiopathic sudden hearing loss and were treated with the same therapy regime and 47 healthy volunteers, who applied to the hospital for routine controls and had audiological and laboratory examination between March 2014 and December 2015, were included in the study. Monocyte/HDL ratios of the patients in the study and control groups were calculated from the results of the blood counts and biochemical analysis. Additionally, the study group was divided into two sub-groups regarding their responses (responders and non-responders) to the treatment determined by the audiological examination, which was carried out after 3 months according to the Siegel criteria. The Monocyte/HDL ratios between the groups were statistically evaluated. There was no statistically significant difference between the MHRs of the study and control groups (p=0.574). However, the MHR was significantly higher in the non-responders? group compared with the responders? group, although they were treated with the same therapy regimen (p=0.005). There was no difference in MHRs between study and control groups. However, as MHR was higher in the patients with good prognosis compared with the patients with bad prognosis, we believe that regarding the ISHL, MHR is not a predictive value but might have prognostic marker.

  4. Improvement of HDL- and LDL-cholesterol levels in diabetic subjects by feeding bread containing chitosan.

    Science.gov (United States)

    Ausar, S F; Morcillo, M; León, A E; Ribotta, P D; Masih, R; Vilaro Mainero, M; Amigone, J L; Rubin, G; Lescano, C; Castagna, L F; Beltramo, D M; Diaz, G; Bianco, I D

    2003-01-01

    In this work we evaluated the efficacy and safety of a bread formulation containing chitosan in dyslipidemic type 2 diabetic subjects. For this purpose a total of 18 patients were allowed to incorporate to their habitual diets 120 g/day of bread containing 2% (wt/wt) chitosan (chitosan group, n= 9) or standard bread (control group, n= 9). Before the study and after 12 weeks on the modified diet, the following parameters were evaluated: body weight, plasma cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglyceride, and hemoglobin A(1c) (HbA(1c)). Compared with the control group, the patients receiving chitosan-containing bread decreased their mean levels of LDL-cholesterol and significantly increased their mean levels of HDL-cholesterol at the end of the study. There were no significant differences in the body weight, serum triglyceride, and HbA(1c). These results suggest that chitosan incorporated into bread formulations could improve the lipoprotein balance similar to typical biliary salts trappers, increasing the HDL- and lowering the LDL-cholesterol, without changing the triglyceride levels. These results warrant further studies over a longer period of time to evaluate if a persistent improvement in levels of lipoproteins can be attained with this strategy.

  5. Effect of Theobromine Consumption on Serum Lipoprotein Profiles in Apparently Healthy Humans with Low HDL-Cholesterol Concentrations.

    Science.gov (United States)

    Jacobs, Doris M; Smolders, Lotte; Lin, Yuguang; de Roo, Niels; Trautwein, Elke A; van Duynhoven, John; Mensink, Ronald P; Plat, Jogchum; Mihaleva, Velitchka V

    2017-01-01

    Scope: Theobromine is a major active compound in cocoa with allegedly beneficial effect on high-density-lipoprotein-cholesterol (HDL-CH). We have investigated the effect of theobromine (TB) consumption on the concentrations of triglyceride (TG) and cholesterol (CH) in various lipoprotein (LP) subclasses. Methods: In a randomized, double-blind, placebo-controlled, cross-over study, 44 apparently healthy women and men (age: 60 ± 6 years, BMI: 29 ± 3 kg/m 2 ) with low baseline HDL-CH concentrations consumed a drink supplemented with 500 mg/d theobromine for 4 weeks. TG and CH concentrations in 15 LP subclasses were predicted from diffusion-edited 1 H NMR spectra of fasting serum. Results: The LP phenotype of the subjects was characterized by low CH concentrations in the large HDL particles and high TG concentrations in large VLDL and chylomicron (CM) particles, which clearly differed from a LP phenotype of subjects with normal HDL-CH. TB only reduced CH concentrations in the LDL particles by 3.64 and 6.79%, but had no effect on TG and CH in any of the HDL, VLDL and CM subclasses. Conclusion: TB was not effective on HDL-CH in subjects with a LP phenotype characterized by low HDL-CH and high TG in VLDL.

  6. Effect of Theobromine Consumption on Serum Lipoprotein Profiles in Apparently Healthy Humans with Low HDL-Cholesterol Concentrations

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    Doris M. Jacobs

    2017-08-01

    Full Text Available Scope: Theobromine is a major active compound in cocoa with allegedly beneficial effect on high-density-lipoprotein-cholesterol (HDL-CH. We have investigated the effect of theobromine (TB consumption on the concentrations of triglyceride (TG and cholesterol (CH in various lipoprotein (LP subclasses.Methods: In a randomized, double-blind, placebo-controlled, cross-over study, 44 apparently healthy women and men (age: 60 ± 6 years, BMI: 29 ± 3 kg/m2 with low baseline HDL-CH concentrations consumed a drink supplemented with 500 mg/d theobromine for 4 weeks. TG and CH concentrations in 15 LP subclasses were predicted from diffusion-edited 1H NMR spectra of fasting serum.Results: The LP phenotype of the subjects was characterized by low CH concentrations in the large HDL particles and high TG concentrations in large VLDL and chylomicron (CM particles, which clearly differed from a LP phenotype of subjects with normal HDL-CH. TB only reduced CH concentrations in the LDL particles by 3.64 and 6.79%, but had no effect on TG and CH in any of the HDL, VLDL and CM subclasses.Conclusion: TB was not effective on HDL-CH in subjects with a LP phenotype characterized by low HDL-CH and high TG in VLDL.

  7. A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fat to modulate serum HDL-cholesterol concentrations.

    Science.gov (United States)

    Baik, Inkyung; Lee, Seungku; Kim, Seong Hwan; Shin, Chol

    2013-10-01

    There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common LPL polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40-69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genome-wide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (S447×) mutation (D' = 0.99) of LPL. We found that carrying the T allele reflecting the LPL ×447 allele was positively associated with follow-up measurement of HDL-C concentrations (P effects of the polymorphism and consumption of alcohol (P-interaction effects of the polymorphism and body mass index (P-interaction alcohol consumption and a diet high in unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the LPL ×447 allele need to control body weight to prevent hypertriglyceridemia.

  8. Parâmetros sangüíneos de pacu Piaractus mesopotamicus (Holmberg, 1887 alimentados com dietas suplementadas com cromo trivalente em duas densidades de estocagem - DOI: 10.4025/actascianimsci.v29i4.1019 Hematological parameters of pacu Piaractus mesopotamicus (Holmberg, 1887 fed diets supplemented with trivalent chromium in two stocking densities - DOI: 10.4025/actascianimsci.v29i4.1019

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    Flávio Ruas de Moraes

    2008-03-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos da suplementação com cromo trivalente (0, 6, 12 e 18 mg kg-1 de ração sobre as variáveis hematológicas de Piaractus mesopotamicus, mantidos em duas densidades de estocagem (4 e 20 kg m-3. Os mantidos na maior densidade e alimentados com dietas suplementadas com 0 e 6 mg de cromo kg-1 apresentaram redução do número de linfócitos circulantes, sugerindo má adaptação a essa condição de alta densidade. Nas dietas suplementadas com 12 e 18 mg kg-1, tal efeito não foi observado, porém verificou-se aumento do número de trombócitos no tratamento com 12 mg de cromo kg-1. A inexistência de diferença significativa entre os tratamentos, aos 30 dias, sugere a adaptação dos peixes ao tipo de alimento e à situação de alta densidade. Portanto, nas condições deste ensaio, a suplementação com 12 e 18 mg de cromo kg-1 é interessante como estratégia alimentar durante 15 dias.This work evaluated the effects of chromium supplementation on the hematological parameters of Piaractus mesopotamicus Holmberg, 1887 maintained in two stocking densities. Fish were fed diets supplemented with 0, 6, 12 and 18 mg trivalent chromium kg-1 dry ration and maintained at 4 and 20 kg m-3. The fish under high stocking density and fed diets supplemented with 0 and 6 mg kg-1 showed reduction in the number lymphocytes, which suggests non-adaptation to this condition of high density. This was not observed in fish fed diets supplemented with 12 and 18 mg chromium kg-1, but an increase in the number of thrombocytes was evident. The lack of difference between treatments after 30 days may suggest a possible adaptation of fish to the situation. It can be added that supplementation with 12 and 18 mg chromium kg-1 is an interesting feeding strategy for a period of 15 days.

  9. Evaluation of non-HDL cholesterol as a predictor of non-fatal cardiovascular events in a prospective population cohort.

    Science.gov (United States)

    Carbayo Herencia, Julio A; Simarro Rueda, Marta; Palazón Bru, Antonio; Molina Escribano, Francisca; Ponce García, Isabel; Artigao Ródenas, Luis Miguel; Caldevilla Bernardo, David; Divisón Garrote, Juan A; Gil Guillén, Vicente Francisco

    2018-01-27

    Non-HDL cholesterol (non-HDL-C) is becoming relevant both in its participation in cardiovascular risk assessment and as a therapeutic target. The objective of the present study was to assess the independent predictive capacity of both non-HDL-C and LDL-C (the main priority in dyslipidemias to reduce cardiovascular risk), in cardiovascular morbidity in a population-based sample. A prospective cohort study involving 1186 individuals in the non-HDL-C group and 1177 in the LDL-C group, followed for 10.7years (SD=2.2), who had not had any previous cardiovascular event. The predictor variables included in the adjustment were: gender, age, arterial hypertension, diabetes mellitus, smoker status and non-HDL-C in one group. In the other group, consisting of patients presenting TG levels of 400mg/dL, non-HDL-C was replaced by LDL-C. Survival curves (Kaplan-Meier) were calculated and two Cox regression models were applied, one for each group. Non-HDL-C group presented 6.2% of non-fatal cardiovascular episodes during follow-up and the LDL-C group 6.0%. After adjustment, for each 30mg/dL increase in non-HDL-C, the incidence of new non-fatal cardiovascular events increased by 31% (HR=1.31, 95%CI: 1.06-1.61; P=.018) and in the LDL-C group by 27% (HR=1.27, 95%CI: 0.97-1.61, P=.068). After a follow-up of 10.7years, non-HDL-C has been shown in our population as a prognostic factor of non-fatal cardiovascular disease, but not LDL-C, although its HR is close to statistical significance. Copyright © 2017 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

  10. HDL levels and oxidizability during myocardial infarction are associated with reduced endothelial-mediated vasodilation and nitric oxide bioavailability.

    Science.gov (United States)

    Carvalho, Luiz Sergio F; Panzoldo, Natália; Santos, Simone N; Modolo, Rodrigo; Almeida, Breno; Quinaglia E Silva, Jose C; Nadruz, Wilson; de Faria, Eliana C; Sposito, Andrei C

    2014-12-01

    Acute phase response modifies high-density lipoprotein (HDL) into a dysfunctional particle that may favor oxidative/inflammatory stress and eNOS dysfunction. The present study investigated the impact of this phenomenon on patients presenting ST-elevation myocardial infarction (STEMI). Plasma was obtained from 180 consecutive patients within the first 24-h of onset of STEMI symptoms (D1) and after 5 days (D5). Nitrate/nitrite (NOx) and lipoproteins were isolated by gradient ultracentrifugation. The oxidizability of low-density lipoprotein incubated with HDL (HDLaoxLDL) and the HDL self-oxidizability (HDLautox) were measured after CuSO4 co-incubation. Anti-inflammatory activity of HDL was estimated by VCAM-1 secretion by human umbilical vein endothelial cells after incubation with TNF-α. Flow-mediated dilation (FMD) was assessed at the 30(th) day (D30) after STEMI. Among patients in the first tertile of admission HDL-Cholesterol (42 mg/dL) tertiles, respectively. From D1 to D5, there was a decrease in HDL size (-6.3 ± 0.3%; p < 0.001) and particle number (-22.0 ± 0.6%; p < 0.001) as well as an increase in both HDLaoxLDL (33%(23); p < 0.001) and HDLautox (65%(25); p < 0.001). VCAM-1 secretion after TNF-a stimulation was reduced after co-incubation with HDL from healthy volunteers (-24%(33); p = 0.009), from MI patients at D1 (-23%(37); p = 0.015) and at D30 (-22%(24); p = 0.042) but not at D5 (p = 0.28). During STEMI, high HDL-cholesterol is associated with a greater decline in endothelial function. In parallel, structural and functional changes in HDL occur reducing its anti-inflammatory and anti-oxidant properties. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  11. Densidad de población y su efecto sobre el rendimiento de papa

    Directory of Open Access Journals (Sweden)

    Rodríguez Loyla

    2004-06-01

    Full Text Available

    En dos localidades del departamento

    de Cundinamarca, el Centro Agropecuario Marengo

    (Mosquera, 2.550 m.s.n.m y el Centro ICA San

    Jorge (Soacha, 3.100 m.s.n.m, se evaluó el efecto de

    la densidad de población (50.000, 125.000, 200.000,

    275.000 y 350.000 plantas∙ha

     

    -1 sobre el rendimiento

    de tubérculos en

     

    Solanum tuberosum L. variedad Parda

    pastusa aplicando el postulado de Duncan (1958. La

    competencia entre plantas determinó la respuesta del

    rendimiento de tubérculos por planta y por hectárea.

    En todas las categorías del tubérculo evaluadas se encontraron

    relaciones lineales negativas para el rendimiento

    por planta en función de la densidad, lo cual

    sustenta la

  12. Densidades de siembra de dos variedades comerciales de crisantemo, Chrysantemum morifolium Ramat en Piendamo (Cauca

    Directory of Open Access Journals (Sweden)

    Posada D. Adolfo

    1986-09-01

    Full Text Available The behavior and agricultural characteristics of two kinds of Chrysanthemum (White Marble and Yellow Polaris were evaluated in terms of yield and quality of the product. Two different kinds of planting systems were applied (single stem and pinched stem. The experimental design in randomized whole blocks for each variety and system including four density treatments (80, 90, 110 and 115 sterns per 1.05 m2 was repeated six times. The experimental unit was of 2.10 m2; 1.26 m2 were harvested. A strong discrepancy between the quantity and quality of the product was observed. The highest yields were obtained with densities of 110 and 115 stems per 1.05 m2. However, the experimental units dis not always met both requirements of a diameter greater than seven cm and three or more marketable flowers per stem. If maximizing production of acceptable bunches is taken as a decision variable, a density of 90 sterns per 1.05 m2 with a 3/3/2/2/2/3/3 arrangement with pinched stern for Yellow Polar is seems a better alternative. As for White Marble, it would be better to have 80 stems per 1.05 m2 with a 3/2/2/2/2/2/3 arrangement in the single stem, but the probability of acceptance is only 0.666. In addition, White Marble showed more susceptibility to dwarfism.Se evaluó el comportamiento y características agronómicas asociadas con el rendimiento y la calidad del producto en las variedades White Marble y Yellow Polaris, en los sistemas de tallo único y tallo despuntado. El diseño experimental de bloques completos al azar para cada variedad y sistema incluía cuatro tratamientos de densidad (80, 90, 110 Y 115 tallos por 1.05 m2, con seis repeticiones. La unidad experimental fue de 2.10 m2, cosechando 1. 26m2(1.05 x 1.20. Se observó marcado antagonismo entre la cantidad y la calidad del producto comercial. Los mayores rendimientos se obtuvieron con densidades de 110 y 115 tallos por 1.05 m2, pero no siempre la producción cumplía con los requisitos de di

  13. Estimação de densidades via Misturas de distribuições "Skew"-normal por processos de Dirichlet"

    OpenAIRE

    Caroline Cavatti Vieira

    2011-01-01

    Este trabalho analisa a estimação de densidades do ponto de vista Bayesiano não-paramétrico. Especificamente, utiliza o modelo hierárquico de misturas por processos de Dirichlet (MDP). O principal objetivo do trabalho é estender o modelo de mistura de distribuições normais por processos de Dirichlet (MNDP) para estimação de densidades, proposto por Escobar e West (1995). Nossa proposta consiste em estimar densidades utilizando um modelo de MDP cujo primeiro estágio é modelado segundo uma mist...

  14. Respuesta fisiológica del ñame espino (Dioscorea Rotundata Poir a las densidades de siembra

    Directory of Open Access Journals (Sweden)

    Dairo J. Pérez

    2015-12-01

    Full Text Available Esta investigación tuvo como objetivo estudiar la respuesta fisiológica del ñame espino (Dioscorea rotundata cv. brasilero en función del incremento de las densidades de siembra, bajo la oferta ambiental del Sinú medio. El estudio se llevó a cabo en la Universidad de Córdoba (Montería, Colombia, donde se evaluaron las densidades de siembra de 45.455, 30.303, 22.727 y 10.101 plantas/ha; bajo un diseño de Bloques Completos al Azar con tres repeticiones. Las variables de respuestas consideradas fueron la fotosíntesis neta (Pn, medida en tres etapas fenológicas (vegetativa, inicio y final de tuberización; y los índices de crecimiento: tasa absoluta de crecimiento (TAC, tasa de asimilación neta (TAN, tasa relativa de crecimiento (TRC e índice de área foliar (IAF. La Pn no varió entre las densidades de siembra (p≤0,05, pero después de la etapa vegetativa, se redujo en promedio un 19,14% para el inicio y final de la tuberización. La TAC y la TRC tuvieron similar tendencia, se incrementaron desde la etapa vegetativa, pero esta última se redujo al final del cultivo. La TAN comenzó a decrecer desde la etapa vegetativa con un leve incremento al final del ciclo. El IAF se incrementó significativamente a partir de la tuberización, para las densidades de siembra superiores a 10.101 plantas/ha, alcanzando valores entre 3,08 y 4,03. Se concluye que los índices de crecimiento a excepción del IAF y la Pn, no variaron entre las densidades de siembra, probablemente por la capacidad de la especie de regular su actividad fisiológica en función de la densidad de siembra.

  15. Perfil docente para alumnos/as con altas capacidades

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    María Leonor Conejeros-Solar

    2013-01-01

    Full Text Available El presente artículo tiene por objeto determinar un perfil de competencias docentes construido desde la percepción de estudiantes con altas capacidades pertenecientes a un programa universitario para talentos académicos. Se utiliza una metodología cualitativa con una estrategia documental de carácter retrospectivo. Los resultados indican que los estudiantes realizan una evaluación profunda sobre la docencia, incluyendo elementos pedagógicos como flexibilidad, ritmo e integración teoría-práctica. Las percepciones de los estudiantes, poco incorporadas en discusiones relativas a la enseñanza, permiten repensar y delinear un perfil de las competencias docentes relevadas para un trabajo pedagógico efectivo con talentosos en el aula.

  16. Arsenoterapia a altas dosis por medio del goteo lento intravenoso

    Directory of Open Access Journals (Sweden)

    Efrain Cabrera

    1941-01-01

    Full Text Available Desde el primer intento de Erlich no se había ensayado nuevamente la realización de la máxima idea, para alcanzar la meta ambicionada por el sabio: "La Sterlisatio Magna". Y más o menos simultáneamente, Tzanck en París, y Hyman y sus colaboradores en New York, intentaron, a principios de la tercera década de este siglo, el método maravilloso que si un día se perfecciona, será la más alta adquisición de la terapéutica antiluética.

  17. UM PERFIL DA EXPANSÃO CANAVIEIRA NA ALTA PAULISTA

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    José Hélio da Silva

    2012-07-01

    Full Text Available O artigo procura analisar, com base nos resultados de pesquisa em curso, a expansão da cana-de-açúcar na micro-região da Alta Paulista e seus principais aspectos. Assim, ao final da explanação, chegamos à conclusão de que o esgotamento da agricultura familiar, o empobrecimento e a expropriação dos pequenos produtores, a substituição de áreas anteriormente destinadas à produção de alimentos e atualmente voltadas à monocultura da cana-de-açúcar e o êxodo rural constituem resultado direto da gestão da ideologia do agronegócio, tendência verificada a partir dos anos 90 e altamente difundida no início do século XXI.

  18. Material management providing best value to TransAlta Utilities

    International Nuclear Information System (INIS)

    Thomas, S.

    1998-01-01

    Materials management functions at TransAlta Utilities were outlined in several overhead viewgraphs. The system includes purchasing, contracts, fleet management, inventory control and warehouses management. Various components of the system are depicted, including: (1) integrated information system, (2) materials management (MM) process flow, (3) key suppliers, (4) commodity categories, (5) performance evaluation process, (6) new ways of working with service suppliers, (7) location of staff in the field and head office, (8) contracts, (9) tracking key performance indicators, (10) blocked invoice performance, and (11) warehouse optimization and inventory control. Current initiatives are being reviewed with a view to reduce operations to a single service centre, based on the corporate objective to increase the value of MM by 20 per cent by the year 2000. 3 tabs., 4 figs

  19. Densidades divergentes y segregación socio-espacial en la Bogotá de hoy: un análisis a partir de un índice de calidad de la densidad

    OpenAIRE

    Alfonso R, Óscar A

    2016-01-01

    La densidad poblacional de Bogotá es bastante diversa al decir de la amplitud de su rango, siendo el mínimo una persona por hectárea y el máximo de 622/ha. Las densidades más elevadas serían la opción más eficiente y socialmente deseable ante la disyuntiva de la densificación o la expansión metropolitana. El problema radica en si tal opción está dotada de la mejor calidad. El objetivo es demostrar que esto no ocurre pues al vincular tres factores que determinan la calidad de la oc...

  20. Estudio de la densidad y de la viscosidad de algunos ácidos grasos puros

    Directory of Open Access Journals (Sweden)

    Cedeño González, Fidel Oscar

    1999-10-01

    Full Text Available An experimental study is carried out according to ASTM analysis methods of two physical properties, density and viscosity, of palmitic, stearic and oleic fatty acids; compounds which are present in the deodorization effluents of edible oils, with a view to their physics chemical characterisation needed for the design of surface condensers and freezers that could be employed in the recovery of these effluents. The measures are carried out every 5 °C, from temperatures close to those of solidification in each compound, of great interest in our study, to 100 °C. The values of these properties are contrasted with those that appear in the literature, and the experimental measures are correlated. Values of the density are also obtained applying Rackett's equation and those of dynamic viscosity using Andrade's equation, and then compared with experimental measures. Experimental data of the dynamic viscosity for oleic acid at low temperatures (between 0 and 24 °C are also presented, because of their interest in the design of the previously mentioned equipment.

    En este trabajo se realiza un estudio experimental de acuerdo con los métodos de análisis de la ASTM de las propiedades físicas, densidad y viscosidad en los ácidos grasos palmítico, esteárico y oleico; compuestos que están presentes en los efluentes de la desodorización de aceites comestibles, con vistas a la caracterización físico química necesaria en el diseño de condensadores y congeladores de superficie que pueden aplicarse a la recuperación de estos efluentes. Las medidas se realizan de 5 en 5 °C entre temperaturas muy próximas a las de solidificación en cada compuesto, de gran interés en nuestro estudio, y los 100 °C. Se contrastan los valores de estas propiedades, con los que aparecen en la literatura y se correlacionan las medidas experimentales. También se obtienen valores de la densidad aplicando la ecuación de Rackett y de la viscosidad din

  1. DESENVOLVIMENTO DA SOJA COM APLICAÇÕES DE HORMÔNIOS EM DIFERENTES DENSIDADES DE CULTIVO

    Directory of Open Access Journals (Sweden)

    Sydney Antonio Frehner Kavalco

    2014-12-01

    NL1, NL2, NL3 e MMG. Ausência de interação foi evidenciada para os caracteres AH e NLH. A utilização de hormônios na dose de 750 ml ha-1 aplicado no estádio R5 da soja contribuiu para o incremento dos caracteres NLH, NRR, NR, CR, NL1, NL2 quando utilizou-se a densidade de 110.000 plantas ha-1. O rendimento de grãos não foi influenciado pelas concentrações de hormônios, mas a densidade de cultivo de 245.000 plantas ha-1 evidenciou superioridade para este caráter. Efeitos diretos positivos ao rendimento de grãos foram revelados através dos caracteres NLH e MMG, e negativos por meio de NLR, NRH, NRR e NL3.

  2. Densidad de oxígeno en el aire y crisis de broncospasmo

    Directory of Open Access Journals (Sweden)

    Roberto Alvarez Sintes

    1995-04-01

    Full Text Available Se realizó un estudio prospectivo en 94 pacientes asmáticos atendidos en el consultorio médico de la familia No. 43 perteneciente al Policlínico Docente "Antonio Maceo" del municipio Cerro de Ciudad de La Habana. Durante un año (junio de 1991 a mayo de 1992 relacionamos las eventualidades diarias del estado de salud de estos pacientes con la densidad de oxígeno en el aire según la fórmula de Gotzek (9/m³ se obtuvieron los datos en el Departamento de Climatología del Instituto de Meteorología de la Academia de Ciencias de Cuba. El análisis estadístico se realizó con el uso del entrecruzamiento de variable, regresión múltiple, método de paso a paso del paquete estadístico SPSS/PC Plus. Se realizó matriz de correlación lineal paramétrica. Se obtuvo correlación significativa directa.

  3. Palmito de pejibaye (Bactris gasipaes cultivado bajo diferentes densidades de laurel (Cordia alliodora

    Directory of Open Access Journals (Sweden)

    Johnny Montenegro

    2001-01-01

    Full Text Available Se evalu6 el incremento en altura y gro- SOT de rebrotes, la altura del tallo dominante, la alliodoproducci6n de palmito y el numero de rebrotes diapOT cepa en plantaciones sin y bajo 2 poblacio- domines de laurel (92 y 370 arboles/ha y el efecto ofdel sombreamiento, en la zona Atlantica de Costa Rica. Se observ6 un mayor incremento en el diametro y la altura de los rebrotes en el monocultivo (P=0.0403, P=0.0033 respectiva- mente unicamente en los estadios iniciales de crecimiento. Una mayor altura del tallo princi- pal (P=0.0143se observ6 en la asociaci6n con haraltas densidades de arboles de laurel. EI nume- ro de rebrotes pOT cepa fue mayor (P=0.05 en maxilas parcelas sin la presencia de arboles. Las ma- yores producciones de palmito fueron encon- whetradas en el monocultivo y con 92 arboles ha/(P=O.O 117, determinandose un menor ren- dimiento con mayores niveles de intercepci6n de luz fotosinteticamente activa pOT parte del estrato arb6reo (r=0.68, P=0.0415. Los ingre- monosos fueron mayores en el tratamiento sin arbo- les, los cuales ejercieron un efecto negativo so- bre el rendimiento productivo del cultivo.

  4. U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies.

    Science.gov (United States)

    Madsen, Christian M; Varbo, Anette; Tybjærg-Hansen, Anne; Frikke-Schmidt, Ruth; Nordestgaard, Børge G

    2017-12-08

    Preclinical evidence has indicated that HDL may play an important role in the immune system; however, very little is known about the role of HDL in the immune system in humans. We tested the hypothesis that low and high concentrations of HDL cholesterol are associated with risk of infectious disease in the general population. We included 97 166 individuals from the Copenhagen General Population Study and 9387 from the Copenhagen City Heart Study with measurements of HDL cholesterol at baseline. The primary endpoint was any infectious disease requiring hospital admission, ascertained in the Danish health registries from baseline in 2003-13 or 1991-94 through 2014; 9% and 31% of individuals in the two studies experienced one or more infectious disease events. Using restricted cubic splines, there was a U-shaped association between concentrations of HDL cholesterol and risk of any infection. Following multifactorial adjustment, individuals with HDL cholesterol below 0.8 mmol/L (31 mg/dL) and above 2.6 mmol/L (100 mg/dL) had hazard ratios for any infection of 1.75 (95% confidence interval 1.31-2.34) and 1.43 (1.16-1.76), compared to those with HDL cholesterol of 2.2-2.3 mmol/L (85-95 mg/dL). In the Copenhagen City Heart Study, corresponding hazard ratios for any infection were 2.00 (1.16-3.43) and 1.13 (0.80-1.60). Low and high HDL cholesterol concentrations found in 21% and 8% of individuals were associated with higher risk of infectious disease in the general population. These findings do not necessarily indicate causality. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.

  5. Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry.

    Science.gov (United States)

    Cao, Jian; Hsu, Yuan-Hao; Li, Sheng; Woods, Virgil L; Dennis, Edward A

    2013-01-01

    Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), specifically Group VIIA PLA(2), is a member of the phospholipase A(2) superfamily and is found mainly associated with LDL and HDL in human plasma. Lp-PLA(2) is considered as a risk factor, a potential biomarker, a target for therapy in the treatment of cardiovascular disease, and evidence suggests that the level of Lp-PLA(2) in plasma is associated with the risk of future cardiovascular and stroke events. The differential location of the enzyme in LDL/HDL lipoproteins has been suggested to affect Lp-PLA(2) function and/or its physiological role and an abnormal distribution of the enzyme may correlate with diseases. Although a mutagenesis study suggested that a surface helix (residues 362-369) mediates the association between Lp-PLA(2) and HDL, the molecular details and mechanism of association has remained unknown. We have now employed hydrogen deuterium exchange mass spectrometry to characterize the interaction between recombinant human Lp-PLA(2) and human HDL. We have found that specific residues 113-120, 192-204, and 360-368 likely mediate HDL binding. In a previous study, we showed that residues 113-120 are important for Lp-PLA(2)-liposome interactions. We now find that residues 192-204 show a decreased deuteration level when Lp-PLA(2) is exposed to apoA-I, but not apoA-II, the most abundant apoproteins in HDL, and additionally, residues 360-368 are only affected by HDL.The results suggest that apoA-I and phospholipid membranes play crucial roles in Lp-PLA(2) localization to HDL.

  6. Produtividade da cenoura, coentro e rúcula em função de densidades populacionais

    Directory of Open Access Journals (Sweden)

    Jailma Suerda Silva de Lima

    2013-04-01

    Full Text Available Um experimento foi conduzido com o objetivo avaliar o desempenho agroeconômico da consorciação cenoura, coentro e rúcula em função de densidades populacionais das culturas. O delineamento experimental utilizado para a tuberosa foi o de blocos casualizados, com quatro tratamentos e 4 repetições. Os tratamentos utilizados foram quatro combinações de densidades populacionais das culturas coentro, cenoura e rúcula (50%-50%-50%, 40%-50%-40%, 30%-50%-30% e 20%-50%-20%. O delineamento experimental utilizado para as folhosas foi o de blocos casualizados, em esquema fatorial 2 x 4, com 4 repetições. Os tratamentos consistiram da combinação de duas épocas de cultivo e quatro combinações de densidades populacionais das culturas coentro, cenoura e rúcula. As características avaliadas na cenoura foram: altura de plantas, número de hastes por planta, massa seca da parte aérea, produtividade comercial, total e classificada de raízes; Nas folhosas foram avaliadas: altura, número de folhas/planta, produtividade, massa seca da parte aérea e os indicadores agroeconômicos, tais como: índice de uso eficiente da terra, renda bruta, renda líquida, taxa de retorno e índice de lucratividade. O maior desempenho agroeconômico do sistema foi verificado na densidade populacional de 30%-50%-30% na primeira época de plantio para as folhosas.

  7. Treatment of HIV infection with a raltegravir-based regimen increases LDL levels, but improves HDL cholesterol efflux capacity.

    Science.gov (United States)

    Funderburg, Nicholas T; Xu, Dihua; Playford, Martin P; Joshi, Aditya A; Andrade, Adriana; Kuritzkes, Daniel R; Lederman, Michael M; Mehta, Nehal N

    2017-01-01

    Persons infected with HIV often have altered lipid profiles that may be affected by antiretroviral therapies (ART). Traditional lipid measurements may be insufficient to assess cardiovascular disease (CVD) risk in this population. We report results from 39 ART-naive participants in a substudy of A5248, a single-arm study of raltegravir, emtricitabine/tenofovir administration. Samples were collected at baseline, 12, 24 and 48 weeks after ART initiation. We performed advanced lipid phenotyping using nuclear magnetic resonance spectroscopy (Liposcience, Raleigh, NC, USA) for lipid particle size and number, and examined high-density lipoprotein (HDL) function measuring reverse cholesterol transport using J774 macrophages. We report significant increases in total cholesterol (13 mg/dl; PLDL; 8 mg/dl; P=0.03), with no change in triglycerides and without an increase in LDL particle number (P>0.1 all time points). HDL levels were increased over baseline levels at all time points (PLDL (oxLDL) levels decreased by week 12, but rose subsequently, and were not different from baseline at later time points. HDL increases were associated with increases in beneficial HDL particles and HDL cholesterol efflux capacity, which may reduce future CVD events. Persistent inflammation in these HIV+ participants, may be a cause or consequence of oxLDL levels, and may contribute to declining levels of HDL over time. Clinicaltrials.gov NCT00660972.

  8. Comparison of effects of diet versus exercise weight loss regimens on LDL and HDL particle size in obese adults

    Directory of Open Access Journals (Sweden)

    Klempel Monica C

    2011-07-01

    Full Text Available Abstract Background Obesity is associated with an atherogenic lipid profile characterized by a predominance of small LDL and HDL particles. Weight loss, by dietary restriction or exercise, increases LDL particle size. Whether these interventions can augment HDL size in conjunction with LDL size remains unknown. Objective This study compared the effects of alternate day fasting (ADF, calorie restriction (CR, and endurance exercise on LDL and HDL particle size in overweight and obese subjects. Methods In a 12-week parallel-arm trial, adult subjects (n = 60 were randomized to 1 of 4 groups: 1 ADF (75% energy restriction for 24-h alternated with ad libitum feeding for 24-h, 2 CR (25% energy restriction every day, 3 exercise (moderate intensity training 3 x/week, or 4 control. Results Body weight was reduced (P P P P = 0.01 by ADF and CR. The proportion of small LDL particles decreased (P = 0.04 with ADF only, and the proportion of large HDL particles increased (P = 0.03 with exercise only. Conclusion These results indicate that dietary restriction increases LDL particle size, while endurance training augments HDL particle size, with minimal weight loss. None of these interventions concomitantly increased both LDL and HDL particle size, however.

  9. Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children

    Directory of Open Access Journals (Sweden)

    Maria Wany Louzada Strufaldi

    Full Text Available Summary Objective: To describe the values of non-HDL cholesterol (NHDL-c and the frequency of a family history of early cardiovascular disease (family HCVD in healthy prepubescent children. Analyze the association between NHDL-c and family HCVD, and possible associations with other risk factors for cardiovascular disease (CVD. Method: Cross-sectional study including 269 prepubescent (aged 6-10 years schoolchildren with a normal body mass index (+1SD-2SD. Data collected: Family HCVD; weight and height, waist circumference and systemic blood pressure; lipid profile (total cholesterol TC, HDL-c, triglycerides and LDL-c, NHDL-c calculation (CT-HDL-c, cut-off = 145 mg/dL and insulin resistance (HOMA-IR. Results: High levels were found for NHDL-c in 10 (3.7% of these schoolchildren, and family early HCVD was found in 46 (17.1% of them. There was a weak association between family HCVD and NHDL-c (Cramer’s-V-test = 0.120; p=0.050. Among the children with NHDL-c≥145 mg/dL, 4 (40% have family HCVD. The presence of family HCVD was not associated with the variables being studied. The variables independently associated with NHDL-c ≥ 145 mg/dL were: HOMA-IR (OR=1.7; 95CI 1.1-2.6 and diastolic blood pressure (OR=1.1; 95CI 1.02-1.2. Conclusion: NHDL-c values were associated with blood pressure and insulin resistance. Family HCVD was not associated with other classic risk factors for CVD, even though the frequency found was five times higher than that of high NHDL-c.

  10. Influência da densidade do solo no desenvolvimento inicial do pinhão-manso cultivado em Latossolo Vermelho eutroférrico

    Directory of Open Access Journals (Sweden)

    Tatiane Ohland

    2014-10-01

    Full Text Available Este trabalho teve por objetivo avaliar a influência da densidade do solo no desenvolvimento inicial da cultura do pinhão-manso. O experimento foi realizado em vasos de 10,6 dm³, em casa de vegetação. O solo utilizado foi o Latossolo Vermelho eutroférrico de textura argilosa, coletado em Marechal Cândido Rondon - PR. O delineamento experimental utilizado foi o de blocos casualizados, composto por cinco níveis de densidade do solo (1,08; 1,22; 1,36; 1,50 e 1,64 kg dm-3, com quatro repetições. Após 120 dias da emergência das plantas, foram efetuadas as avaliações biométricas e as relativas ao do tecido vegetal. Houve redução de 25% da altura das plantas, na densidade de 1,64 kg dm-3, quando,comparada com a da densidade de 1,08 kg dm-3. Para o comprimento radicular, a redução foi de aproximadamente 24 , 35 , 54 e 66 % para as densidades de 1,22; 1,36; 1,50 e 1,64 kg dm-3 respectivamente, quando comparadas com o da densidade de 1,08 kg dm-3. A limitação do desenvolvimento da parte aérea ocorreu a partir da densidade estimada de 1,26 kg dm-3, com redução do número de folhas, da área foliar e da produção de matéria seca da parte aérea. O desenvolvimento do sistema radicular e o conteúdo de P e K nas plantas de pinhão-manso reduziram-se linearmente com o aumento da densidade do solo.

  11. Medida de densidades con el picnómetro y de tensión superficial con el estalagmómetro

    OpenAIRE

    Espinosa Tomás, Julián; Pérez Rodríguez, Jorge; Miret Marí, Juan José; Caballero Caballero, María Teresa

    2010-01-01

    Guión de la práctica de Física de primero de grado de Óptica y Optometría "MEDIDA DE DENSIDADES CON EL PICNÓMETRO Y DE TENSIÓN SUPERFICIAL CON EL ESTALAGMÓMETRO" Objetivos: Medir densidades de sólidos y líquidos. Medir la tensión superficial de un líquido problema con el estalagmómetro.

  12. Aclimatação de mudas de acariquara à alta irradiância Acclimation of manwood seedlings to full sunlight

    Directory of Open Access Journals (Sweden)

    Nilvanda dos Santos Magalhães

    2009-07-01

    Full Text Available O objetivo deste trabalho foi determinar as mudanças fisiológicas que ocorrem em acariquara (Minquartia guianensis durante o processo de aclimatação à alta irradiância, bem como a estratégia de aclimatação dessa espécie. Plantas mantidas em baixa irradiância foram transferidas para alta irradiância por 290 dias. Durante esse período, foi medida a relação entre fluorescência variável e máxima (Fv/Fm, em folhas desenvolvidas à sombra e, após a senescência prematura por foto-oxidação, em folhas aclimatadas ao sol. Ao final do experimento, foram determinadas as características fotossintéticas e anatômicas da folha. A exposição à alta irradiância causou, logo após a transferência, forte fotoinibição e foto-oxidação parcial da folhagem, mas não provocou a morte da planta. Folhas produzidas no ambiente ensolarado apresentaram valores de Fv/Fm similares aos do controle. A fotossíntese saturada por luz e a fotossíntese saturada por CO2 foram 90 e 50% maiores em plantas aclimatadas à alta irradiância. A velocidade máxima de carboxilação da rubisco e a taxa máxima de regeneração da ribulose bisfosfato seguiram a mesma tendência. Folhas produzidas ao sol apresentaram maior densidade estomática e maior espessura foliar. A produção de folhas novas é a principal estratégia de aclimatação da acariquara à alta irradiância.The aim of this work was to determine the physiological changes that occur in manwood (Minquartia guianensis during the acclimation process to high irradiance, and also to determine the acclimation strategy of this species. Plants kept in low light were transferred to high irradiance for 290 days. During this period the ratio between variable fluorescence and maximum fluorescence (Fv/Fm was measured in leaves developed in the shade, and after premature senescence due to photooxidation, in sun-acclimated leaves. At the end of the experimental period the anatomic and photosynthetic

  13. An overview of review guidelines for HDL programmable devices in nuclear safety systems

    International Nuclear Information System (INIS)

    Komanduri, Raghavan; Srivani, L.; Thirugnana Murthy, D.

    2013-01-01

    HDL programmable devices viz. CPLDs and FPGAs are increasingly being used to implement digital designs in the I and C systems performing safety functions of nuclear power plants. Synthesizable RTL descriptions manually written in HDLs are the first step in developing industry standard large scale digital designs. The reliability of the implementation is determined by the methodologies followed by the designer during development. Very few guidelines on HPD design practices, specific to nuclear industry are available. This paper presents an overview of the existing guidelines such as IEC 62566 and U.S. NRC's 'Review guidelines for FPGAs in nuclear power plant safety systems'. (author)

  14. PENGARUH PEMBERIAN EKSTRAK PEPAYA TERHADAP KADAR KOLESTEROL TOTAL, LDL DAN HDL DARAH TIKUS PUTIH JANTAN HIPERKOLESTEROLEMIA

    Directory of Open Access Journals (Sweden)

    Endrinaldi Endrinaldi

    2012-05-01

    Full Text Available AbstrakPepaya mengandung pektin yang merupakan serat larut air. Pektin berkemampuan mengikat asam empedu dan dieliminasi keluar tubuh melalui feses. Penurunan jumlah asam empedu di lumen usus menyebabkan hepar menggunakan kolesterol dalam darah untuk membentuk asam empedu. Hal tersebut mengakibatkan penurunan jumlah kolesterol.Tujuan studi ini adalah untuk melihat pengaruh pemberian ekstrak pepaya mengkal terhadap kadar kolesterol total, HDL dan LDL tikus putih. Desain penelitian ini adalah eksperimental menggunakan 20 ekor tikus putih jantan yang dibagi menjadi empat kelompok, yaitu kelompok kontrol, dan kelompok perlakuan dengan pemberian ekstrak pepaya dengan dosis 0,5 ml, 1 ml dan 1,5 ml per 200g/BB melalui oral selama 15 hari.Hasil penelitian menunjukkan terjadinya penurunan rerata kadar kolesterol total, LDL, dan peningkatan kadar HDL serum tikus setelah pemberian ekstrak pepaya selama 15 hari secara bermakna (p<0,05. Tetapi tidak terjadi perbedaan yang bermakna (p>0,05 antara kelompok yang diberi ekstrak pepaya dengan dosis 0,5 ml, 1 ml, dan 1,5 ml.Kesimpulan yang dapat diambil dari studi ini ialah bahwa ekstrak pepaya dapat menurunkan kadar kolesterol total, LDL, dan peningkatan kadar HDL pada serum tikus putih jantanKata kunci : pektin, kolesterol, asam empedu, serat, tikus.AbstractPapaya contain pectin which is a water-soluble fiber. Pectin has the ablity to bind bile acids and eliminated out of the body through the feces. Decrease in the amount of bile acids in intestinal lumen causing liver uses cholesterol to synthesize bile acids blood.The purpose of this study was to see the effect of papaya extract on total cholesterol, HDL and LDL of male rats. This is an experimental research design using 20 white male rats were divided into four groups : control group and group treated with papaya extract a dose of 0,5 ml, 1 ml per 200 gr/body weight orally for 15 days.Results showed a decrease in everage total cholesterol, LDL and increased

  15. Statin action enriches HDL3 in polyunsaturated phospholipids and plasmalogens and reduces LDL-derived phospholipid hydroperoxides in atherogenic mixed dyslipidemia

    Science.gov (United States)

    Tan, Ricardo; Giral, Philippe; Robillard, Paul; Kontush, Anatol; Chapman, M. John

    2016-01-01

    Atherogenic mixed dyslipidemia associates with oxidative stress and defective HDL antioxidative function in metabolic syndrome (MetS). The impact of statin treatment on the capacity of HDL to inactivate LDL-derived, redox-active phospholipid hydroperoxides (PCOOHs) in MetS is indeterminate. Insulin-resistant, hypertriglyceridemic, hypertensive, obese males were treated with pitavastatin (4 mg/day) for 180 days, resulting in marked reduction in plasma TGs (−41%) and LDL-cholesterol (−38%), with minor effects on HDL-cholesterol and apoAI. Native plasma LDL (baseline vs. 180 days) was oxidized by aqueous free radicals under mild conditions in vitro either alone or in the presence of the corresponding pre- or poststatin HDL2 or HDL3 at authentic plasma mass ratios. Lipidomic analyses revealed that statin treatment i) reduced the content of oxidizable polyunsaturated phosphatidylcholine (PUPC) species containing DHA and linoleic acid in LDL; ii) preferentially increased the content of PUPC species containing arachidonic acid (AA) in small, dense HDL3; iii) induced significant elevation in the content of phosphatidylcholine and phosphatidylethanolamine (PE) plasmalogens containing AA and DHA in HDL3; and iv) induced formation of HDL3 particles with increased capacity to inactivate PCOOH with formation of redox-inactive phospholipid hydroxide. Statin action attenuated LDL oxidability Concomitantly, the capacity of HDL3 to inactivate redox-active PCOOH was enhanced relative to HDL2, consistent with preferential enrichment of PE plasmalogens and PUPC in HDL3. PMID:27581680

  16. Influência da densidade de plantio e sistema de podas na produção de café Influence of plant density and pruning system on the yield of coffee

    Directory of Open Access Journals (Sweden)

    Sérgio Vasco de Toledo

    1999-08-01

    Full Text Available Durante 19 anos, foi conduzido um experimento em Campinas, SP, que objetivou avaliar a influência da variedade, espaçamento, número de plantas na cova e sistema de condução da planta sobre a produção de café (Coffea arabica L.. As variedades Mundo Novo e Caturra foram estudadas com cinco densidades de plantio (1, 2, 3, 5 e 6 m²/cova combinadas com uma ou duas plantas por cova e conduzidas sem podas, decotadas a 2 m de altura e recepadas em esquema predeterminado, tipo Beaumont & Fukunaga. Os resultados de 17 colheitas demonstraram que altas densidades de plantio apresentaram elevadas produções nas primeiras safras, com acentuado decréscimo após sete colheitas; a variedade Mundo Novo manteve o potencial produtivo, enquanto a Caturra diminuiu sensivelmente a produção ao longo dos anos; a adoção de um sistema de podas não influenciou na produção, e em alguns períodos foi prejudicial.An experiment with the objective of evaluating the influence of the number of plants per hole, plant density and pruning system on the yield of the Caturra and Mundo Novo varieties of Coffea arabica L. was carried out in Campinas, SP, Brazil, during 19 years. Five planting densities were evaluated: 1, 2, 3, 5 and 6 m²/hole, combined with one and two plants per hole carried out without pruning; pruning at 2 m from the soil; and, plants lapped close to the soil in a regime pre-determinated by Beaumont & Fukunaga. High planting density showed high yields in the first harvests with pronounced decrease after seven harvests. The Mundo Novo variety kept its yield potential while the Caturra variety highly decreased its yield throughout the years; the adoption of a pruning system did not influence the yield and was even prejudicial in some periods.

  17. Performance of juvenile turbot (Scophthalmus maximus fed varying dietary L-carnitine levels at different stocking densities Desempenho de juvenis de pregado (Scophthalmus maximus em função da densidade de estocagem e de níveis dietéticos de L-carnitina

    Directory of Open Access Journals (Sweden)

    José Fernando Magalhães Gonçalves

    2010-04-01

    (75,6 ± 2,8 g alimentados durante 75 dias a dois níveis dietéticos de L-carnitina (40 ou 240 mg kg¹. Após esse período, determinou-se a excreção de amônia pós-prandial durante 24 horas. Os peixes cultivados na menor densidade, 4 kg m², apresentaram melhores taxas de crescimento e ganho de peso (94-96 g em comparação aos mantidos em altas densidades (80-87 g. A taxa de eficiência proteica foi mais elevada a 4 kg m² (1,33-1,36, do que a densidades de 8 kg m² (0,98 ou 14 kg m² (0,45. A ingestão voluntária de alimento decresceu de 0,70 para 0,56% do peso corporal com o incremento da densidade. A suplementação de carnitina não afetou o crescimento e a composição corporal, com exceção do conteúdo de carnitine da carcaça que passou de 75 a 128 mg kg¹. Peixes alimentados com suplementos de 240 mg L-carnitina apresentam excreção de amônia mais baixa comparativamente aos alimentados com 40 mg L-carnitina (p < 0,05.

  18. Influência da granulometria de grânulos de amido sobre a densidade aparente de extratos atomizados

    Directory of Open Access Journals (Sweden)

    E. R. Daiuto

    2009-01-01

    Full Text Available

    Amidos e seus derivados são utilizados como carregadores em processos de secagem de produtos por atomização onde a densidade aparente é característica importante e deve ser controlada nos produtos desidratados de uso farmacêutico. No Brasil os amidos comerciais são originários de milho e mandioca, mas existem outros com potencial para extração. Os amidos de biri e taro foram selecionados por representarem extremos de tamanho de grânulos e assim verificar o efeito do tamanho sobre a densidade aparente de produtos desidratados por atomização. Foram usados para comparação os amidos comerciais de mandioca e milho, por serem de uso comum em produtos atomizados e apresentarem tamanhos intermediários de grânulos. A atomização foi feita em Spray Dryer Lab Plant SD 04, operando sob pressão de 6 lb/in2, fluxo 7,6 mL/mim, e bico 1 cm. A temperatura de entrada foi fixada em 200ºC mas este modelo de equipamento não permite regular a temperatura de saída. Os produtos atomizados tiveram extrato de boldo como base, usando os quatro amidos como suporte. O produto seco foi avaliado quanto à umidade, atividade de água, tamanho das partículas e densidade aparente. Os resultados mostraram que o tamanho das partículas, e por decorrência do tamanho dos grânulos de amido, têm influência sobre a densidade aparente do produto final, que foi maior (694, 27 g/mL para o amido de biri e menor (456,13 g/mL para amido de taro. Os amidos de milho e mandioca proporcionaram valores muito próximos e intermediários, de 521, 51 e 581, 48 g/mL, que representam também o padrão de variação de tamanho dos grânulos. Palavras-chave: atomização; densidade aparente; granulometria; amidos.

  19. Hubungan Kadar Trigliserida dan Kolesterol-HDL Terhadap Kadar Alanine Aminotransferase pada Pasien Non Alcoholic Fatty Liver Disease

    Directory of Open Access Journals (Sweden)

    Bayu Gemilang

    2016-01-01

    Full Text Available AbstrakTrigliserida dan Kolesterol HDL (c-HDL merupakan beberapa dari komponen Sindroma Metabolik (SM. SM dipercaya merupakan faktor utama penyebab Non Alcoholic Fatty Liver Disease (NAFLD. NAFLD merupakan penyakit hati kronik yang nantinya dapat menyebabkan fibrosis sel-sel hepar dan juga keganasan. NAFLD tidak menunjukkan manifestasi klinis yang khas, sehingga diperlukan pemeriksaan penunjang seperti pemeriksaan enzim hati untuk menegakkan diagnosis. Alanine Aminotransferase (ALT menjadi pilihan sebagai marker pada penyakit NAFLD. Tujuan penelitian ini adalah menentukan hubungan antara trigliserida dan c-HDL dengan ALT pada penderita NAFLD. Ini merupakan penelitian analitik deskriptif dengan desain retrospektif menggunakan data pasien NAFLD di instalasi rekam medik RSUP dr.M.Djamil Padang. Sampel penelitian ini adalah 51 pasien NAFLD. Hasil penelitian didapatkan dari uji korelasi pearson terdapat derajat hubungan yang kuat (r=0,512 dan hubungan yang bermakna (p<0,001 antara kadar trigliserida dengan kadar ALT serum dan derajat hubungan yang sedang (r=0,26 dan hubungan yang tidak bermakna (p=0,065 antara c-HDL dengan ALT serum. Kesimpulan penelitian ini adalah kadar ALT berhubungan dengan kadar trigliserida pada penderita NAFLD, namun tidak dengan c-HDLKata kunci: NAFLD, trigliserida, HDL, ALT, sindroma metabolik AbstractTriglyceride and HDL Cholesterol (HDL-C are some of the Metabolic Syndrome (MS components. MS is believed as the main factor for the Non Alcoholic Fatty Liver Disease (NAFLD. NAFLD is a chronic liver disease, which later can cause hepatocyte fibrosis and also malignancy. NAFLD does not show a typical clinical appearance, so it is important to do workups such as liver enzyme test to make the diagnosis. Alanine Aminotransferase (ALT is considered as the marker of NAFLD.The objective of this study was to determine the relationship between triglycerides and HDL-C to ALT level in NAFLD patients.This  was a descriptive analytical

  20. Coconut oil increases HDL-c and decreases triglycerides in wistar rats

    Directory of Open Access Journals (Sweden)

    Lidiani Figueiredo Santana

    2016-09-01

    Full Text Available Changes in body composition and serum lipid profile in rats, supplemented with coconut oil, are evaluated and compared to other lipid sources. Female Wistar rats received by gavage 1 mL kg-1 of saline, soybean oil, lard or coconut oil during 21 days. At the end of the study period, body composition, food intake, feces, urine, organ weight and serum lipid profile were assessed. No statistical differences between the groups were found in body composition, food intake, fecal and urinary analysis, and organ weight. In the case or plasma lipid concentrations, coconut oil and lard raised total cholesterol levels, without changes in LDL levels. On the other hand there was no change in total cholesterol levels in the soybean oil group. HDL fraction increased in all groups when compared to that in the saline group; this increase was more significant in the coconut oil group. There was significant reduction of serum triglycerides only in the coconut oil group when compared to the saline group. Supplementation with coconut oil did not interfere in weight and body composition of the animals used in current study, but revealed significant effect on the increase of HDL-c levels and decrease of serum triglycerides.

  1. Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport

    Science.gov (United States)

    Ikhlef, Souade; Berrougui, Hicham; Kamtchueng Simo, Olivier; Zerif, Echarki

    2017-01-01

    This study was aimed to investigate the effect of human PON1 overexpression in mice on cholesterol efflux and reverse cholesterol transport. PON1 overexpression in PON1-Tg mice induced a significant 3-fold (pparaoxonase activity and a significant ~30% (p<0.0001) increase in the capacity of HDL to mediate cholesterol efflux from J774 macrophages compared to wild-type mice. It also caused a significant 4-fold increase (p<0.0001) in the capacity of macrophages to transfer cholesterol to apoA-1, a significant 2-fold (p<0.0003) increase in ABCA1 mRNA and protein expression, and a significant increase in the expression of PPARγ (p<0.0003 and p<0.04, respectively) and LXRα (p<0.0001 and p<0.01, respectively) mRNA and protein compared to macrophages from wild-type mice. Moreover, transfection of J774 macrophages with human PON1 also increased ABCA1, PPARγ and LXRα protein expression and stimulates macrophages cholesterol efflux to apo A1. In vivo measurements showed that the overexpression of PON1 significantly increases the fecal elimination of macrophage-derived cholesterol in PON1-Tg mice. Overall, our results suggested that the overexpression of PON1 in mice may contribute to the regulation of the cholesterol homeostasis by improving the capacity of HDL to mediate cholesterol efflux and by stimulating reverse cholesterol transport. PMID:28278274

  2. A VLSI Implementation of Four-Phase Lift Controller Using Verilog HDL

    Science.gov (United States)

    Kumar, Manish; Singh, Priyanka; Singh, Shesha

    2017-08-01

    With the advent of an era of staggering range of new technologies to provide ease of mobility and transportation elevators have become an essential component of all high rise buildings. An elevator is a type of vertical transportation that moves people between the floors of a high rise building. A four-Phase lift controller modeled on Verilog HDL code using Finite State Machine (FSM) has been presented in this paper. Verilog HDL helps in automated analysis and simulation of lift controller circuit. This design is based on synchronous input that operates on a fixed frequency. The Lift motion is controlled by means of accepting the destination floor level as input and generate control signal as output. In the proposed design a Verilog RTL code is developed and verified. Project Navigator of XILINX has been used as a code writing platform and results were simulated using Modelsim 5.4a simulator. This paper discusses the overall evolution of design and also discusses simulated results.

  3. Concretos secos produzidos com agregados reciclados de RCD separados por densidade

    Directory of Open Access Journals (Sweden)

    Raphael Baldusco da Silva

    Full Text Available ResumoO uso de agregados reciclados de resíduos de construção e demolição (RCD em blocos de concreto permite compatibilizar as diferentes características de composição e porosidade desses agregados com os diferentes níveis de exigência mecânica em uso dos blocos. Paralelamente, concretos secos são pouco estudados porque a energia de prensagem obtida em vibroprensas não é facilmente reprodutível em escala de laboratório; porém, parte dessa limitação pode ser superada, realizando-se a avaliação do comportamento da mistura (sob confinamento com prensas de laboratório com controle de deformação. Assim, o objetivo deste artigo foi analisar o comportamento do concreto seco (no estado fresco e endurecido produzido com agregados de RCD (separados ou não por densidade, empregando-se esse método laboratorial de prensagem. Com substituição total do agregado natural pelo agregado reciclado misto obtido por processo de jigagem obteve-se resistências à compressão comparáveis às dos concretos de referência. A influência das características dos agregados e das formulações de concretos secos foi identificada pela técnica de compactação laboratorial. A redução da porosidade do agregado reciclado e a otimização da granulometria da mistura seca (cimento e agregados foram os parâmetros mais importantes para o incremento de resistência observado.

  4. Very low levels of HDL cholesterol and atherosclerosis, a variable relationship – a review of LCAT deficiency

    Directory of Open Access Journals (Sweden)

    Savel J

    2012-06-01

    Full Text Available Julia Savel,1,2 Marianne Lafitte,1 Yann Pucheu,1,3 Vincent Pradeau,1 Antoine Tabarin,2,3 Thierry Couffinhal1,3,41Centre d'Exploration, de Prévention et de Traitement de l'Athérosclérose, Hôpital Cardiologique, 2Service d'endocrinologie, CHU Bordeaux, Université Bordeaux Segalen, Bordeaux, France; 3Université de Bordeaux Adaptation cardiovasculaire à l'ischémie, 4INSERM, Adaptation cardiovasculaire à l'ischémie, U1034, Pessac, FranceAbstract: A number of epidemiological and clinical studies have demonstrated that plasma high-density lipoprotein (HDL level is a strong inverse predictor of cardiovascular events. HDL is believed to retard the formation of atherosclerotic lesions by removing excess cholesterol from cells and preventing endothelial dysfunction. Lecithin cholesterol acyltransferase (LCAT plays a central role in the formation and maturation of HDL, and in the intravascular stage of reverse cholesterol transport: a major mechanism by which HDL modulates the development and progression of atherosclerosis. A defect in LCAT function would be expected to enhance atherosclerosis, by interfering with the reverse cholesterol transport step. As such, one would expect to find more atherosclerosis and cardiovascular events in LCAT-deficient patients. But this relationship is not always evident. In this review, we describe contradictory reports in the literature about cardiovascular risks in this patient population. We discuss the paradoxical finding of severe HDL deficiency and an absence of subclinical atherosclerosis in LCAT-deficient patients, which has been used to reject the hypothesis that HDL level is important in the protection against atherosclerosis. Furthermore, to illustrate this paradoxical finding, we present a case study of one patient, referred for evaluation of global cardiovascular risk in the presence of a low HDL cholesterol level, who was diagnosed with LCAT gene mutations.Keywords: atherosclerosis, LCAT function

  5. Densidade Mineral Óssea em Mulheres Asmáticas, na Fase Perimenopausa

    Directory of Open Access Journals (Sweden)

    Anne K. Laatikainen

    1999-07-01

    Full Text Available RESUMO: Os corticóides inalados, constituem a terapêutica anti-inflamatória de eleição, utilizada nos asmáticos, por longos penodos.Para além dos corticóides inalados utilizados como terapêutica preventiva, a corticoterapia oral e endovenosa é por vezes necessária nos períodos de exacerbação da doença.É bem conhecido o risco de osteoporose em doentes com asma grave medicados com corticoterapta oral a longo prazo O efeito dos corticóides inalados a nivel da densidade óssea, não é bem conhecido, pelo que tem sido alvo de estudos recentes.A menopausa é considerada o principal factor de risco da osteoporose. Ainda não é bem conhecido qual o papel da asma como factor de risco de ostcoporose equal o impacto dos corticóides inalados na densitometria óssea.Os autores procederam a urn estudo inicialmente dingido a uma população de 14220 mulheres dos 47 aos 56 anos de idade (período perimenopausa, residentes na Província de Kuopio, no Leste da Finlândia.Foi enviado urn inquérito incluindo a história ginecológica, uso de terapêutica hormonal de substituição, paridade, peso, altura, actividade fisica, consumo de produtos lácteos, hábitos tabágicos, morbilidade e teraêuticas habituais. Houve resposta em 84 4% dos inquiridos.Foi realizada osteodensitometria óssea (BMD do colo do fémur esquerdo e coluna em 3222 mulheres, de acordo com um estudo randomizado simples, estratificado.Após exclusão de alguns registos considerados inválidos, a população estudada consistia em 2941 mulheres, das quais 119 eram asmáticas. A estas foi feito um inquérito adicional acerca do uso de cortticóides, dose diária, duração e regularidade.Os autores verificaram que 72 doentes (60.5% estavam medicadas com corticóides inalados. Dez asmáticas faziam regularmente corticoterapia oral. Em 61 doentes havia referência a pelo menos um curso de corticóide oral nos últimos 6 meses. Vinte e oito asmáticas nunca tinham feito terap

  6. Effects of the construction of a high density earth fill over the Merluza gas pipeline right-of-way; Efeitos da construcao de aterro de alta densidade sobre a faixa do gasoduto Merluza

    Energy Technology Data Exchange (ETDEWEB)

    Musman, Jacqueline V.R.; Soares, Jose P. [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil)

    2003-07-01

    In this work, we present the studies for evaluation of the effects of the construction of a high-density earth fill over Merluza gas pipeline right-of-way. The earth fill construction has provoked vertical displacements because of consolidation of the foundation soil, which is consisted of soft clay deposits. So the pipeline is being submitted to tension stresses. The studies included pipeline stress-strain analyses, hardness tests and displacements calculation based on consolidation theory. IPT - Instituto de Pesquisas Tecnologicas made the pipeline stress-strain analyses using the finite element method. Theses analyses indicated tension stresses above the yield limits in some elements. CENPES - Centro de Pesquisas da PETROBRAS made some hardness tests to verify the numerical results. After this, TRANSPETRO evaluated the vertical displacements using consolidation theory. Some laboratory tests were made using undisturbed samples of the soft soil. All these studies were made to verify safety and structural integrity of the gas pipeline. (author)

  7. Preparation and characterization of high density polyethylene and residual fibre of Attalea funifera Mart (piacava) composites; Preparacao e caracterizacao de compositos de polietileno de alta densidade com residuos de fibras de piacava da especie Attalea funifera Mart

    Energy Technology Data Exchange (ETDEWEB)

    Agrela, Sara P.; Guimaraes, Danilo H.; Jose, Nadia M., E-mail: saraagrela@hotmail.co [Universidade Federal da Bahia (GECIM/IQ/UFBA), Salvador, BA (Brazil). Inst. de Quimica. Grupo de Energia e Ciencias dos Materiais; Carvalho, Gleidson G.P. [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil). Escola de Medicina Veterinaria. Dept. de Producao Animal; Carvalho, Ricardo F. [Universidade Federal da Bahia (EP/UFBA), Salvador, BA (Brazil). Escola Politecnica. Curso de Mestrado em Engenharia Ambiental Urbana

    2009-07-01

    The use of natural fiber reinforcement thermoplastic polymer is continuously increasing. This fact is manly due to its advantages as low cost, availability, recyclability, low energy demand and then environmental appeal if compared to synthetics fibers. The composites were prepared in different fiber volume ratios (5%, 10% and 20%) mixed with high density polyethylene (HDPE) and heated at 190 deg C. Thermogravimetric analysis and differential scanning calorimetry were used to investigate thermal stability. The composites structure was characterized by Fourier Transform Infrared spectroscopy, X-ray diffractometry. Fiber and residue of piassava (Attalea funifera Mart) chemical composition were determined by Van Soest Method. The results indicate that thermo stability of the composites of HDPE prepared with fiber volume ratios up to 20% is only slightly lowered. (author)

  8. Dosimetry characterization and clinical application of Exa skin: Bolus of high of high density for use with photons; Caracterizacion dosimetrica y aplicacion clinica de Exaskin: bolus de alta densidad para uso con fotones

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz Seidel, M.; Velazquez Miranda, S.

    2013-07-01

    Bolus of high density eXaSkin of density 1.6 g/cm{sub 3} is calculated correctly in the planning systems, is easy to use and generates optimum coupling with the radiation area, at the same time which is easily reproducible in their placement, avoiding the use of electron beams. On the other hand its behavior varies very slightly with the presence of air gaps. (Author)

  9. Características de compósitos laminados manufaturados com polietileno de alta densidade (PEAD e diferentes proporções de casca de arroz e partículas de madeira

    Directory of Open Access Journals (Sweden)

    Dalva Teresinha Pauleski

    2007-01-01

    Full Text Available The objective of this work was to analyse the feasibility of the utilization of rice husks and wood particles in the manufacture of wood plastic composites, in a way similar to particleboard fabrication. The composites were made with rice husks and Eucalyptus grandis wood particles, pure or mixed, in proportions of 0, 25, 50, 75 and 100% of ovendry weight. High density polyethylene (HDPE was used as matrix in the manufacture in three proportions: 60, 75, and 90%. Bending properties, internal bond, water absorption and thickness swelling after 24 hours of water soaking and after 15 soaking cycles were evaluated. The values of bending properties were influenced by the density of the composite. In the case of internal bond, the values were within the limits established by commercial particleboard standards, being the HDPE proportion the parameter of higher correlation with this property. Rice husk caused lower thickness swelling and, independently of the type of raw material utilised, the values decreased with the increase of HDPE. Combinations with larger percentages of HDPE presented minimal values or, in some cases, null of water absorption. For the water absorption and thickness swelling after 15 cycles the behavior was similar to that of the 24 hour period. Results allowed concluding that the composites made with HDPE, rice husks and wood particles pure or mixed present good quality, evidencing the adequacy of these raw material and process in manufacturing this type of panel.

  10. TransAlta Corporation 1996 annual report : new directions, new opportunities

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    TransAlta Corp. is an energy management company that operates through two subsidiaries: (1) TransAlta Utilities Corp. which owns and operates electricity generation, transmission and distribution assets in Alberta, and (2) TransAlta Energy Corp. which is in the business of electric and thermal energy supply, gas and electricity distribution, energy services and energy marketing in regions of Canada, New Zealand, Australia, Argentina and the United States. This report presents a summary of operations, and provides consolidated financial statements and common share information for 1996. During the year the corporation advanced three significant initiatives (1) operational effectiveness, as shown by impressive productivity increases, and major investments in three independent power projects, (2) improved strategic direction through a review of plans and options, resulting in a clearer, more focused vision of the future, and (3) realignment of the organizational structure by centralizing marketing and sales functions, and establishing a corporate business development group. Details of operational and financial results were provided for both subsidiaries, i. e. TransAlta Utilities and TransAlta Energy. Sales of electric energy for TransAlta Utilities amounted to 27.8 billion kWh; 4.6 billion kWh for TransAlta Energy. Return on equity was 11.4 per cent, down from 11.8 per cent in 1995. Net earnings per common share were $1.14 per share (including one-time items), the same as in 1995. tabs., figs

  11. Percepción socioemocional de los profesores en adolescentes con altas habilidades versus habilidades medias

    Directory of Open Access Journals (Sweden)

    Mari Carmen FERNÁNDEZ

    2011-01-01

    Full Text Available El objetivo de este trabajo es estudiar la percepción que los profesores tienen sobre las competencias socioemocionales de sus alumnos adolescentes, según la excepcionalidad (alta habilidad vs. no alta habilidad y el género. La muestra estuvo compuesta por 443 profesores pertenecientes a 55 centros de Educación Secundaria Obligatoria de la Región de Murcia. El instrumento utilizado fue el EQ-i, YV-O dirigido a profesores (BAR-ON & PARKER, en prensa. Los resultados indicaron, según la excepcionalidad de los alumnos (alta habilidad vs. no alta habilidad, que los profesores percibieron al grupo de alumnos de alta habilidad más adaptados, con mayor estado de ánimo y con mayores habilidades interpersonales. Respecto al género, los profesores valoraron con mayor manejo del estrés a los chicos. Además, según la excepcionalidad (alta habilidad vs. no alta habilidad y el género, los datos mostraron diferencias estadísticamente significativas para las dimensiones adaptabilidad, estado de ánimo e intrapersonal.

  12. Relationship between TG/HDL-C ratio and metabolic syndrome risk factors with chronic kidney disease in healthy adult population.

    Science.gov (United States)

    Ho, Chih-I; Chen, Jau-Yuan; Chen, Shou-Yen; Tsai, Yi-Wen; Weng, Yi-Ming; Tsao, Yu-Chung; Li, Wen-Cheng

    2015-10-01

    The triglycerides-to-high-density lipoprotein-cholesterol (TG/HDL-C) ratio has been identified as a biomarker of insulin resistance and a predictor for atherosclerosis. The objectives of this study were to investigate which the TG/HDL-C ratio is useful to detect metabolic syndrome (MS) risk factors and subclinical chronic kidney disease (CKD) in general population without known CKD or renal impairment and to compare predictive accuracy of MS risk factors. This was a cross-sectional study. A total 46,255 subjects aged ≥18 years undergoing health examination during 2010-2011 in Taiwan. The independent associations between TG/HDL-C ratio quartiles, waist circumstance (WC) waist-to-height ratio (WHtR), mean atrial pressure (MAP), and CKD prevalence was analyzed by using logistic regression models. Analyses of the areas under receiver operating characteristic (ROC) were performed to determine the accuracy of MS risk factors in predicting CKD. A dose-response manner was observed for the prevalence of CKD and measurements of MS risk factors, showing increases from the lowest to the highest quartile of the TG/HDL-C ratio. Males and females in the highest TG/HDL-C ratio quartile (>2.76) had a 1.4-fold and 1.74-fold greater risk of CKD than those in the lowest quartile (≤1.04), independent of confounding factors. Mean arterial pressure (MAP) had the highest AUC for predicting CKD among MS risk factors. The TG/HDL-C ratio was an independent risk factor for CKD, but it showed no superiority over MAP in predicting CKD. A TG/HDL-C ratio ≥2.76 may be useful in clinical practice to detect subjects with worsened cardiometabolic profile who need monitoring to prevent CKD. TG/HDL-C ratio is an independent risk factor for CKD in adults aged 18-50 years. MAP was the most powerful predictor over other MS risk factors in predicting CKD. However, longitudinal and comparative studies are required to demonstrate the predictive value of TG/HDL-C on the onset and progression of CKD over

  13. Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.

    Directory of Open Access Journals (Sweden)

    Giovanni Zuliani

    Full Text Available While the relationship between total cholesterol (TC and cardiovascular disease (CVD progressively weakens with aging, several studies have shown that low TC is associated with increased mortality in older individuals. However, the possible additive/synergic contribution of the two most important cholesterol rich fractions (LDL-C and HDL-C to mortality risk has not been previously investigated. Our study aimed to investigate the relationship between baseline LDL-C and HDL-C, both separately and combined, and 9-years mortality in a sample of community dwelling older individuals from the InCHIANTI study.1044 individuals over 64 years were included. CVD and cancer mortality were defined by ICD-9 codes 390-459 and 140-239, respectively. LDL-C <130 mg/dL (3.36 mmol/L was defined as "optimal/near optimal". Low HDL-C was defined as <40/50 mg/dL (1.03/1.29 mmol/L in males/females, respectively. Nine-years mortality risk was calculated by multivariate Cox proportional hazards model. We found that, compared to subjects with high LDL-C and normal HDL-C (reference group, total mortality was significantly increased in subjects with optimal/near optimal LDL-C and low HDL-C (H.R.:1.58; 95%CI:1.11-2.25. As regards the specific cause of death, CVD mortality was not affected by LDL-C/HDL-C levels, while cancer mortality was significantly increased in all subjects with optimal/near optimal LDL-C (with normal HDL-C: H.R.: 2.49; with low HDL-C: H.R.: 4.52. Results were unchanged after exclusion of the first three years of follow-up, and of subjects with low TC (<160 g/dL-4.13 mmol/L.Our findings suggest that, in community dwelling older individuals, the combined presence of optimal/near optimal LDL-C and low HDL-C represents a marker of increased future mortality.

  14. Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage.

    Science.gov (United States)

    Berrougui, Hicham; Isabelle, Maxim; Cherki, Mounia; Khalil, Abdelouahed

    2006-12-14

    The objective of the present study was to elucidate the beneficial properties of aqueous extracts of Marrubium vulgare (AEM) towards cardiovascular disease by protecting human-LDL against lipid peroxidation and promoting HDL-mediated cholesterol efflux. Human-LDL were oxidised by incubation with CuSO(4) in the presence of increased concentrations of AEM (0-100 microg/ml). LDL lipid peroxidation was evaluated by conjugated diene formation, vitamin E disappearance as well as LDL-electrophoretic mobility. HDL-mediated cholesterol efflux assay was carried out in human THP-1 macrophages. Incubation of LDL with AEM significantly prolonged the lag phase (P=0.014), lowered the progression rate of lipid peroxidation (P=0.004), reduced the disappearance of vitamin E and the electrophoretic mobility in a dose-dependent manner. Also, incubation of HDL with AEM significantly increased HDL-mediated cholesterol efflux from THP-1 macrophages implicating an independent ATP binding cassette A1 (ABCA1) pathways. Our findings suggest that M. vulgare provides a source of natural antioxidants, which inhibit LDL oxidation and enhance reverse cholesterol transport and thus can prevent cardiovascular diseases development. These antioxidant properties increase the anti-atherogenic potential of HDL.

  15. Impact of Lifestyle Intervention on HDL-Induced eNOS Activation and Cholesterol Efflux Capacity in Obese Adolescent

    Directory of Open Access Journals (Sweden)

    Jenny Wesnigk

    2016-01-01

    Full Text Available Background. Endothelial dysfunction occurs in obese children and adolescent and is regarded as a key step in the development of atherosclerosis. Important components for the development of endothelial dysfunction are reduced activity of endothelial nitric oxide synthase (eNOS and an increase in cholesterol deposition in the vessel wall, due to reduced reverse cholesterol transport (RCT activity. High density lipoprotein (HDL exhibits antiatherosclerotic properties including modulation of eNOS activity and cholesterol efflux capacity. Lifestyle intervention programs can modify endothelial dysfunction in obese adolescents, but their impact on HDL-mediated eNOS activation and RCT is unknown so far. Methods. Obese adolescents (15±1 years, BMI > 35 kg/m2 where randomized either to an intervention group (IG, n=8; restricted diet and exercise or to a usual care group (UC, n=8. At the beginning and after 10 months of treatment HDL-mediated eNOS phosphorylation and cholesterol efflux capacity were evaluated. Results. Ten months of treatment resulted in a substantial weight loss (−31%, an improvement of endothelial function, and an increase in HDL-mediated eNOS-Ser1177 phosphorylation and RCT. A correlation between change in eNOS-Ser1177 phosphorylation or RCT and change in endothelial function was noted. Conclusion. A structured lifestyle intervention program improves antiatherosclerotic HDL functions, thereby positively influencing endothelial function.

  16. Adrenal Function in females with low plasma HDL-C due to mutations in ABCA1 and LCAT.

    Directory of Open Access Journals (Sweden)

    Andrea E Bochem

    Full Text Available INTRODUCTION: Adrenal steroidogenesis is essential for human survival and depends on the availability of the precursor cholesterol. Male subjects with low plasma levels of high density lipoprotein (HDL cholesterol are characterized by decreased adrenal function. Whether this is also the case in female subjects with low plasma HDL-C levels is unresolved to date. FINDINGS: 15 female ATP binding cassette transporter AI (ABCAI and 14 female lecithin-cholesterol acyltransferase (LCAT were included in the study. HDL-C levels were 38% and 41% lower in ABCA1 and LCAT mutation carriers compared to controls, respectively. Urinary steroid excretion of 17-ketogenic steroids or 17-hydroxy corticosteroids did not differ between 15 female ABCA1 mutation carriers (p = 0.27 vs 0.30 respectively and 30 matched normolipidemic controls or between 14 female LCAT mutation carriers and 28 matched normolipidemic controls (p = 0.10 and 0.14, respectively. Cosyntropin testing in an unselected subgroup of 8 ABCA1 mutation carriers and 3 LCAT mutation carriers did not reveal differences between carriers and controls. CONCLUSION: Adrenal function in females with molecularly defined low HDL-C levels is not different from controls. The discrepancy with the finding of impaired steroidogenesis in males with molecularly defined low HDL-C levels underscores the importance of gender specific analyses in cholesterol-related research.

  17. Altas capacidades intelectuales. Diagnóstico y seguimiento de una NEE.

    OpenAIRE

    Pérez-i-Martra, Pep

    2013-01-01

    Según la OMS, el 2,3% de la población mundial tiene altas capacidades intelectuales, es decir, en la vida académica de un profesor, éste tendría que descubrir una media de 40 alumnos con capacidades superiores a la media. Saber en qué consisten las altas capacidades y hacer un pre diagnóstico de las mismas será, en muchas ocasiones, trabajo del profesor de secundaria. Pero, ¿tiene éste conocimientos para percatarse de la presencia en clase de un alumno con altas capacidades? ¿Y una vez estudi...

  18. IDENTIFICACIÓN DE MICROALGAS OLEAGINOSAS EN EL ÁREA DE CONCESIÓN PARA CONSERVACIÓN, CUENCA ALTA DEL RÍO ITAYA. LORETO-PERÚ

    Directory of Open Access Journals (Sweden)

    Marianela Cobos Ruiz

    2012-12-01

    Full Text Available Las microalgas oleaginosas constituyen una nueva alternativa para la producción de biodiesel, por su alta eficiencia fotobiosintética de triglicéridos y presentan productividades mayores de 10 a 100 veces que los cultivos convencionales. Además que actúan como sumideros de CO2 y pueden usar aguas servidas para producir biodiesel. Sin embargo, los estudios sobre identificación de este tipo de microalgas en la amazonía son escasos. El objetivo del presente trabajo de investigación fue identificar especies de microalgas oleaginosas con potencial aplicación para la producción de biodiesel que se encuentran en ambientes acuáticos del Área de Concesión para Conservación de la Universidad Científica del Perú (UCP. La colecta de las muestras se realizó del 27/06/12 al 03/07/12 entre las 12 y 15 h utilizando red planctónica tipo cono y como preservante formol al 3%. La identificación microscópica se realizó en el Laboratorio de Ciencias Básicas de la UCP. La densidad de las microalgas fue realizada en base a su conteo en cámaras de Neubauer  y Sedgwick-Rafter. Los resultados muestran la presencia de 20 especies de microalgas, de las cuales cinco son microalgas oleaginosas. Correspondiente a las del género Chlorella quienes presentaron la mayor densidad promedio (6x104 células/ml en las tres cochas evaluadas.

  19. Tomografia computadorizada quantitativa periférica de alta resolução para avaliação de parâmetros morfológicos e funcionais ósseos

    Directory of Open Access Journals (Sweden)

    Henrique Fuller

    2015-08-01

    Full Text Available RESUMOA tomografia computadorizada quantitativa periférica de alta resolução (HR-pQCT é uma nova tecnologia disponível comercialmente há menos de 10 anos que permite a feitura de exames in vivo para a avaliação de parâmetros ósseos. A HR-pQCT avalia a forma, o número, o volume, a densidade, a conectividade e a separação das trabéculas; a densidade e a espessura do osso cortical e o volume e a densidade total, em alta definição, o que permite a construção digital da microarquitetura óssea adicionalmente. A aplicação de cálculos matemáticos aos dados capturados, método denominado elemento finito (FE, permite a estimativa das propriedades físicas do tecido e simula cargas suportadas de forma não invasiva. Desse modo, a HR-pQCT adquire simultaneamente dados antes fornecidos separadamente pela densitometria óssea, pela ressonância magnética e pela histomorfometria e agrega estimativas biomecânicas antes só possíveis em tecidos extraídos. A reprodutibilidade do método é satisfatória, com coeficientes de variação que raramente ultrapassam os 3%. Quanto à acurácia, os parâmetros apresentam de regular a boa concordância (r2= 0,37-0,97.A principal aplicação clínica é na quantificação e no monitoramento das doenças osteometabólicas, porque avalia de modo mais completo a resistência óssea e o risco de fratura. Na artrite reumatoide permite-se a aferição do número e do tamanho das erosões e dos cistos, além do espaço articular. Na osteoartrite é possível caracterizar as áreas edema-símile que guardam correlação com a degradação da cartilagem.Restritas ainda a um instrumento de pesquisa, dado o seu elevado custo, a alta resolução e a eficiência mostram-se como vantagens em relação aos métodos atualmente usados para a avaliação óssea, com um potencial para tornar-se uma importante ferramenta na prática clínica.

  20. Defectos eritrocíticos y densidad de la parasitemia en pacientes con malaria por Plasmodium falciparum en Buenaventura, Colombia Erythrocyte defects and parasitemia density in patients with Plasmodium falciparum malaria in Buenaventura, Colombia

    Directory of Open Access Journals (Sweden)

    Martha Moyano

    2005-07-01

    Full Text Available OBJETIVOS: Determinar la prevalencia de algunos defectos eritrocíticos y evaluar su relación con la densidad de la parasitemia en personas con diagnóstico de malaria (paludismo por Plasmodium falciparum en una población del Pacífico colombiano. MÉTODOS: Se realizó un estudio de prevalencia en 242 personas con malaria por P. falciparum que consultaron al Programa de Enfermedades Tropicales en la ciudad de Buenaventura, Colombia. Se midieron los niveles de parasitemia y se determinó la presencia de defectos eritrocíticos congénitos (deficiencia de glucosa-6-fosfato deshidrogenasa [G6PD] y presencia de hemoglobinas anormales y de talasemias y de otros factores potencialmente relacionados con los niveles de parasitemia. RESULTADOS: La prevalencia obtenida de defectos eritrocíticos fue de 26,4% (IC95% 21,0 a 32,5, similar a la hallada en estudios realizados antes en la misma zona. En los modelos de regresión múltiple, las personas con drepanocitosis o deficiencia total de la G6PD presentaron una menor densidad de parasitemia que las personas sin defecto, y el riesgo de parasitemias altas fue menor en estas personas después de ajustes respecto a otras variables de interés (razón de posibilidades [odds ratio, RP]: 0,30 y 0,72, respectivamente. CONCLUSIONES: Los resultados confirman una alta prevalencia de defectos eritrocíticos en el Pacífico colombiano, en una población con características étnicas similares a las de algunas poblaciones del África Occidental, y aportan información en favor de la existencia de resistencia innata a la malaria en personas portadoras de hemoglobina AS o con deficiencia de la G6PD.OBJECTIVES: To determine the prevalence of some erythrocyte defects and to evaluate the relation that that has with parasitemia density in individuals diagnosed with Plasmodium falciparum malaria in a population in the Pacific coastal region of Colombia. METHODS: This prevalence study was carried out with 242 persons with P

  1. Densidade populacional e seu efeito na produtividade da mamoneira BRS Energia sob cultivo irrigado

    Directory of Open Access Journals (Sweden)

    Gibran da Silva Alves

    Full Text Available RESUMOA mamoneira é uma planta oleaginosa arbustiva e o óleo de suas sementes possui inúmeras aplicações industriais. No Nordeste do Brasil destaca-se como alternativa para geração de emprego e renda na agricultura familiar. Contudo, na atualidade tem-se dado ênfase ao seu emprego na produção de combustível renovável (biodiesel. A escolha do espaçamento e da época de plantio adequados são passos tecnológicos básicos, que podem favorecer uma maior produção de grãos por planta pelo surgimento de mais racemos por planta com maior tamanho e número de frutos. Objetivou-se com o presente trabalho estudar os efeitos de diferentes populações de plantas de mamoneira (Ricinus communis L. cv. BRS Energia quanto ao teor de óleo e produtividade. O experimento foi conduzido na Fazenda Experimental da Embrapa Algodão, localizada no município de Barbalha-CE, onde se trabalhou em delineamento aleatorizado em blocos com cinco populações de plantas (10.000; 16.666; 25.000; 50.000 e 100.000 plantas ha-1 com quatro blocos. Utilizou-se o método de irrigação por aspersão. Com base nos resultados do estudo, verificou-se que o crescimento das plantas aumentou em função do incremento da população de 10.000 até 100.000 plantas ha-1, a produtividade de grãos foi ajustada em função das populações testadas, o teor de óleo decresceu com o aumento da densidade populacional, os componentes de produção estudados decresceram com o aumento da população de plantas no intervalo considerado.

  2. Non-leaky vesiculation of large unilamellar vesicles (LUV) induced by plasma high density lipoproteins (HDL): Detection by HPLC

    International Nuclear Information System (INIS)

    Tischler, U.; Rueckert, D.S.; Schubert, R.; Jaroni, H.W.; Schmidt, K.H.

    1989-01-01

    Interaction of large unilamellar phosphatidylcholine vesicles (LUV, 75nm) and plasma high density lipoproteins (HDL) resulted in a non-leaky vesiculation of LUV. This vesiculation was detected by a HPLC-system consisting of a combination of three TSK-gel columns (6000PW, 5000PW, 3000SW). With increasing incubation time liposomal [ 14 C]PC, entrapped [ 3 H]inulin, and apoprotein of HDL origin decreased. The decrease was accompanied by a formation of new particles, consisting of liposomal PC and apoprotein. These particles also enclosed [3H]inulin, reflecting a hydrophilic inner space. The formation of the particles reached a maximum after one day of incubation. Retention time was 21 minutes for LUV, 28 minutes for the new particles, and 36 minutes for HDL. In vesicles with membranes consisting of phosphatidylcholine and 30% cholesterol no interactions were observed

  3. DISTRIBUCIÓN ESPACIAL, COMPOSICIÓN Y DENSIDAD DE EDAFOFAUNA EN HOJARASCA DE BOSQUE Y CAFETAL (MONTENEGRO, COLOMBIA)

    OpenAIRE

    Diana Marcela RUEDA-RAMÍREZ; Amanda VARELA

    2016-01-01

    Se determinaron los cambios en composición, densidad y distribución espacial de la edafofauna de hojarasca entre dos usos de suelo (cafetal y bosque subandino) para entender el efecto del uso de suelo. Asimismo, se establecieron las relaciones entre las variables de la edafofauna y atributos de la hojarasca. Se colectaron muestras de hojarasca superficial durante la época seca y se extrajo la edafofauna, manualmente y mediante embudos Berlese modificados. Esta se identificó hasta el menor ...

  4. Funcionalización de polietileno de baja densidad con anhídrido maleico en estado fundido

    OpenAIRE

    Guzmán,Manuel; A. Murillo,Edwin

    2014-01-01

    En este estudio, polietileno de baja densidad (PEBD) fue modificado con anhídrido maleico (AM) en estado fundido usando concentraciones diferentes de peróxido de dicumilo (DCP) (0.25, 0.50, 0.75 y 1.0 %). Los materiales obtenidos fueron caracterizados por contenido de gel, titulaciones ácido-base, análisis infrarrojo (IR), calorimetría de barrido diferencial (DSC), análisis termogravimétrico (TGA), análisis reológico, propiedades mecánicas, dureza y permeabilidad al oxígeno. El análisis reomé...

  5. El histograma como un instrumento para la comprensión de las funciones de densidad de probabilidad

    OpenAIRE

    Behar Gutierrez, Roberto; Grima Cintas, Pedro

    2013-01-01

    Tradicionalmente los profesores de Estadística de nivel medio y superior hemos mirado la Estadística Descriptiva como una temática divorciada de la probabilidad y de la Inferencia. Cuando llega el momento de explicar el histograma, generalmente se construyen intervalos de igual tamaño y el eje de las ordenadas representa directamente la frecuencia relativa. Sin embargo, cuando trata la temática de las funciones de densidades en probabilidad, para calcular la probabilidad, qu...

  6. Avaliação de dietas de diferentes densidades energéticas para codorna japonesa em postura

    OpenAIRE

    Moura, Guilherme de Souza

    2007-01-01

    Dois experimentos foram realizados com codornas japonesas em fase de produção. No primeiro experimento foi avaliado o desempenho e a qualidade de ovos de codornas japonesas quando submetidas à dietas de diferentes densidades energéticas, mantendo constante a relação energia metabolizável (EM):lisina digestível. Neste estudo, foram utilizadas 400 codornas japonesas dos 76 aos 160 dias de idade, distribuídas em um delineamento inteiramente casualizado, contendo 5 tratamentos (2900, 2800, 2700, ...

  7. Densidade do solo no ambiente solo-semente e velocidade de emergência em sistema de semeadura de milho

    OpenAIRE

    Reis,Elton Fialho dos; Schaefer,Carlos Ernesto G.R.; Fernandes,Haroldo Carlos; Naime,João de Mendonça; Araújo,Eduardo Fontes

    2006-01-01

    O microambiente próximo à semente é influenciado diretamente pelo tipo de mecanismo de abertura do sulco e elemento compactador do solo. Nesse sentido, este trabalho objetivou avaliar a densidade do solo na região da semente, em sistema plantio direto, utilizando a tomografia computadorizada. O experimento foi montado em esquema de parcelas subsubdivididas, em que as parcelas foram constituídas de três teores de água do solo (0,22; 0,28; e 0,34 kg kg-1); as subparcelas, de dois mecanismos de ...

  8. Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats

    Directory of Open Access Journals (Sweden)

    Neves Valdir A

    2011-09-01

    Full Text Available Abstract Background This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin, in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals. Methods Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9: 1 standard (STD: fed on casein as protein source; 2 hypercholesterolemic (HC: STD plus 1% cholesterol and 0.5% cholic acid; 3 HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day; 4 HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day; 5 HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3 and (4. The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain. Results A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet. Conclusion Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin and the protein (glycinin were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism.

  9. Audiitor kaebas Alta Capitali arve pärast Läti kohtusse / Henrik Ilves

    Index Scriptorium Estoniae

    Ilves, Henrik

    2008-01-01

    Eesti Päevalehe andmetel kaebas rahvusvaheline audiitorfirma Ernst & Young Lätis kohtusse investeerimisfirma Alta Capital, kuna firma ei ole maksnud esitatud arvet. Nõude suuruseks on 4,69 miljonit krooni

  10. Plasma kinetics of an LDL-like nanoemulsion and lipid transfer to HDL in subjects with glucose intolerance

    Directory of Open Access Journals (Sweden)

    Marina P Bertato

    2012-01-01

    Full Text Available OBJECTIVE: Glucose intolerance is frequently associated with an altered plasma lipid profile and increased cardiovascular disease risk. Nonetheless, lipid metabolism is scarcely studied in normolipidemic glucose-intolerant patients. The aim of this study was to investigate whether important lipid metabolic parameters, such as the kinetics of LDL free and esterified cholesterol and the transfer of lipids to HDL, are altered in glucose-intolerant patients with normal plasma lipids. METHODS: Fourteen glucose-intolerant patients and 15 control patients were studied; none of the patients had cardiovascular disease manifestations, and they were paired for age, sex, race and co-morbidities. A nanoemulsion resembling a LDL lipid composition (LDE labeled with 14C-cholesteryl ester and ³H-free cholesterol was intravenously injected, and blood samples were collected over a 24-h period to determine the fractional clearance rate of the labels by compartmental analysis. The transfer of free and esterified cholesterol, triglycerides and phospholipids from the LDE to HDL was measured by the incubation of the LDE with plasma and radioactivity counting of the supernatant after chemical precipitation of non-HDL fractions. RESULTS: The levels of LDL, non-HDL and HDL cholesterol, triglycerides, apo A1 and apo B were equal in both groups. The 14C-esterified cholesterol fractional clearance rate was not different between glucose-intolerant and control patients, but the ³H-free-cholesterol fractional clearance rate was greater in glucose-intolerant patients than in control patients. The lipid transfer to HDL was equal in both groups. CONCLUSION: In these glucose-intolerant patients with normal plasma lipids, a faster removal of LDE free cholesterol was the only lipid metabolic alteration detected in our study. This finding suggests that the dissociation of free cholesterol from lipoprotein particles occurs in normolipidemic glucose intolerance and may participate in

  11. Difference in effect of myristic and stearic acid on plasma HDL cholesterol within 24 h in young men.

    Science.gov (United States)

    Tholstrup, T; Vessby, B; Sandstrom, B

    2003-06-01

    There is increasing evidence that postprandial triacylglycerol (TAG)-rich lipoproteins (TRL) may be related to atherogenic risk. Little is known about the acute effect of individual dietary saturated fatty acids on plasma lipids and lipoproteins. To investigate the effect of two prevalent dietary saturated fatty acids, stearic and myristic acid on postprandial and 24 h fasting plasma lipoprotein TAG and cholesterol concentrations. Ten young healthy men were served two meals (1.2 g fat/kg body weight) containing fat enriched in either stearic acid (S) (shea butter) or myristic acid (M) (produced by inter-esterification) in a randomised, cross-over study. The meals were given in the morning after 12 h of fasting and again after 8 h (in the afternoon). The S and M containing meals were given at different days separated by a washout period. Blood samples were taken before the meal and 2,4,6,8, and 24 h after the first meal. The M meal resulted in a higher postprandial HDL TAG response than S (P=0.03 I), (diet x time interaction), while no differences were observed in other lipid fractions. Twenty-four hours after the M meal fasting, HDL cholesterol was higher (P=0.05) and HDL TAG lower (P<0.001) than at baseline. Intake of individual dietary SFA may affect fasting HDL cholesterol within 24 h. Thus after this short period HDL cholesterol concentration was higher after myristic acid than stearic acid. Myristic acid resulted in a higher increase in postprandial HDL TAG than stearic acid.

  12. Impacto do exercício físico isolado e combinado com dieta sobre os níveis séricos de HDL, LDL, colesterol total e triglicerídeos Impact of isolated and combined with diet physical exercise on the HDL, LDL, total cholesterol and triglycerides plasma levels

    Directory of Open Access Journals (Sweden)

    Sanmira Fagherazzi

    2008-08-01

    Full Text Available Adequados hábitos alimentares e a prática de exercícios físicos exercem efeito benéfico sobre as dislipidemias. Se associados, podem ainda otimizar as mudanças do perfil lipoprotéico plasmático, sendo, além disso, intervenções de custo moderado quando comparados com tratamentos medicamentosos e dependentes de alta tecnologia. Este estudo tem por objetivo avaliar o impacto do exercício físico isolado e combinado com dieta sobre o perfil lipídico em indivíduos com sobrepeso/obesos. O presente trabalho é do tipo retrospectivo analítico observacional. Nele foi analisada a evolução do perfil lipídico e do peso, por período entre três e seis meses, de 30 indivíduos, divididos em dois grupos: grupo exercício (prática de exercício físico e grupo dieta (prática de exercício físico associada à intervenção nutricional. Foram encontradas reduções estatisticamente significativas no CT (-14,4mg/dl; P = 0,022 e no LDL-c (-20,9mg/dl; P = 0,013 para os componentes do grupo exercício. Tal redução também ocorreu em relação à razão CT/HDL-c (-0,9; P = 0,005 para os componentes do grupo dieta. Foi observada elevação dos níveis de HDL-c, apenas no grupo dieta (+4,2 mg/dl. Nesse mesmo grupo verificou-se diminuição no CT (-8mg/dl e no LDL-c (-9,8mg/dl, bem como redução de peso (-2,6kg, no entanto, tais resultados não foram estatisticamente significativos. Quanto aos níveis de TG, não foi verificada evolução positiva em ambos os grupos. Concluiu-se que o efeito isolado do exercício físico foi mais evidente em relação às variáveis CT e LDL-c. Os TG não sofreram modificações positivas com a prática exclusiva de exercícios físicos ou com sua associação à dieta. Para as variáveis HDL-c e peso, a combinação da dieta com o exercício físico apresentou maiores benefícios.Adequate eating habits and physical exercise have a beneficial effect on dislipidemies. When associated, they might even optimize

  13. Variação da Cor da Madeira de Teca em Função da Densidade e do Teor de Extrativos

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    Rosilei Aparecida Garcia

    Full Text Available RESUMO O objetivo deste estudo foi avaliar o efeito da densidade e do teor de extrativos na variação da cor da madeira de teca (Tectona grandis L. f. proveniente de plantios de diferentes espaçamentos. As análises colorimétricas foram realizadas nas faces radial e tangencial das madeiras de cerne e alburno com o espectrofotômetro CM 2600d no espaço de cor L*a*b*. A densidade e o teor de extrativos foram determinados segundo as normas ASTM D2395 e ASTM D1105. A madeira do maior espaçamento de plantio apresentou maior densidade e maior teor de extrativos. Na seção radial, as madeiras de cerne de maior densidade apresentaram mais pigmento amarelo, enquanto que na seção tangencial elas são mais escuras e apresentam menos pigmento amarelo. As madeiras de alburno de maior densidade são mais escuras e apresentam mais pigmento vermelho em ambas as seções. As madeiras mais escuras e com mais pigmento vermelho apresentaram um maior teor de extrativos.

  14. [Effect of healthy diet and physical activity on the level of non-HDL cholesterol in obese subjects without cardiovascular disease and diabetes mellitus].

    Science.gov (United States)

    Móczár, Csaba

    2015-10-18

    Prevention program including lifestyle changes was initiated with the participation of obese and overweight subjects recruited from the practices of 29 family doctors. The aim of the author was to analyse changes of non-HDL-cholesterol levels, especially when triglyceride levels were above 2.26 mmol/l, and when non-HDL cholesterol levels were high in association with low HDL-cholesterol levels in overweight or obese subjects who had no cardiovascular disease and diabetes mellitus. Data obtained from 1192 subjects (424 men and 768 women) before and 12 month after inclusion into the prevention program was analysed. The average level of non-HDL-cholesterol in the whole group of subjects decreased from 4.74 to 4.64 mmol/l, but the change was not significant. However, the average concentration of non-HDL-cholesterol was reduced significantly from 4.87 to 4.4 mmol/l in men, whereas no significant change was detected in women. In cases when triglyceride levels were higher than 2.26 mmol/l, the non-HDL-cholesterol level was reduced by 0.65 mmol/l. In cases when the non-HDL-cholesterol level was high in association with low HDL-cholesterol level, the non-HDL-cholesterol was significantly decreased from 5.22 to 4.48 mmol/l. In addition, in cases when HDL-cholesterol levels were low, the average level of the HDL-cholesterol significantly increased from 0.84 to 1.3 mmol/l. Lifestyle changes decrease the level of atherogenic lipid fractions, particularly in men with high triglyceride levels. Improvement of the atherogenic lipid profile in response to lifestyle changes is related not only to the reduction of atherogenic lipid fractions, but also to the increase of HDL-cholesterol level.

  15. The low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion.

    Science.gov (United States)

    Gogonea, Valentin; Gerstenecker, Gary S; Wu, Zhiping; Lee, Xavier; Topbas, Celalettin; Wagner, Matthew A; Tallant, Thomas C; Smith, Jonathan D; Callow, Philip; Pipich, Vitaliy; Malet, Hélène; Schoehn, Guy; DiDonato, Joseph A; Hazen, Stanley L

    2013-04-01

    Small-angle neutron scattering (SANS) with contrast variation was used to obtain the low-resolution structure of nascent HDL (nHDL) reconstituted with dimyristoyl phosphatidylcholine (DMPC) in the absence and presence of cholesterol, [apoA1:DMPC (1:80, mol:mol) and apoA1:DMPC:cholesterol (1:86:9, mol:mol:mol)]. The overall shape of both particles is discoidal with the low-resolution structure of apoA1 visualized as an open, contorted, and out of plane conformation with three arms in nascent HDL/dimyristoyl phosphatidylcholine without cholesterol (nHDL(DMPC)) and two arms in nascent HDL/dimyristoyl phosphatidylcholine with cholesterol (nHDL(DMPC+Chol)). The low-resolution shape of the lipid phase in both nHDL(DMPC) and nHDL(DMPC+Chol) were oblate ellipsoids, and fit well within their respective protein shapes. Modeling studies indicate that apoA1 is folded onto itself in nHDL(DMPC), making a large hairpin, which was also confirmed independently by both cross-linking mass spectrometry and hydrogen-deuterium exchange (HDX) mass spectrometry analyses. In nHDL(DMPC+Chol), the lipid was expanded and no hairpin was visible. Importantly, despite the overall discoidal shape of the whole particle in both nHDL(DMPC) and nHDL(DMPC+Chol), an open conformation (i.e., not a closed belt) of apoA1 is observed. Collectively, these data show that full length apoA1 retains an open architecture that is dictated by its lipid cargo. The lipid is likely predominantly organized as a bilayer with a micelle domain between the open apoA1 arms. The apoA1 configuration observed suggests a mechanism for accommodating changing lipid cargo by quantized expansion of hairpin structures.

  16. Small HDL subclasses become cholesterol-poor during postprandial period after a fat diet intake in subjects with high triglyceridemia increases.

    Science.gov (United States)

    Quintanilla-Cantú, Armando; Peña-de-la-Sancha, Paola; Flores-Castillo, Cristobal; Mejía-Domínguez, Ana María; Posadas-Sánchez, Rosalinda; Pérez-Hernández, Nonanzit; Bautista-Pérez, Rocío; Enriquez-Calderón, Reyna Esmeralda; Juárez-Oropeza, Marco Antonio; Fragoso, José Manuel; Vargas-Alarcón, Gilberto; Pérez-Méndez, Oscar

    2017-01-01

    Postprandial triglyceridemia may transitory affect the structure of HDL subclasses and probably their antiatherogenic properties but little is known in this field. We analyzed the HDL subclasses lipid content along postprandial period. Fifteen metabolic syndrome (MS) patients and 15 healthy controls were enrolled. HDL were isolated from plasma samples obtained at fasting and every 2-h up to 8-h, after a 75-g fat meal. Cholesterol (C), triglycerides (TAG), and phospholipid (Ph) plasma concentrations of five HDL subclasses were determined by densitometry of electrophoresis gels enzymatically stained. The increase of postprandial triglyceridemia expressed as the incremental area under the curve (iAUC) was twice in MS patients than in controls. Only large HDL2b-TAG were higher in MS than controls at 4, 6 and 8h after meal intake, whereas cholesterol of HDL2a, 3a and 3b were lower at 8h. HDL size distribution shifted towards large HDL and HDL3a-, 3b- and 3c-subclasses had a lower content of cholesterol (estimated by the C-to-Ph ratio) in subjects whose iAUC>289.5mgh/dl (n=15) in comparison with those subjects with iAUC below this cutoff point (n=15), independently of the MS status and fasting TAG. Triglycerides content of HDL subclasses changed only discreetly along the postprandial period, whereas paraoxonase-1 remained unchanged. A high postprandial triglyceridemia conditions the shift of HDL size distribution towards large particles and the decrease of cholesterol in HDL3 subclasses. These data demonstrate that postprandial hypertriglyceridemia contributes to a transitory hypoalphalipoproteinemia that may increase the risk of cardiovascular disease. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Neuromielitis óptica con alta expresión de acuaporina-4 y anticuerpos anti-acuaporina-4 positivos en suero

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    Alejandra Báez

    2012-04-01

    Full Text Available La presencia de anticuerpos IgG en suero, con blanco en los canales de acuaporina-4, es específica de la neuromielitis óptica (NMO. El 60% de los pacientes con NMO presentan lesiones cerebrales en la resonancia magnética (RM; en un 8% (mayoría niños estas lesiones se consideraron "atípicas". Presentamos dos pacientes con NMO y lesiones en el SNC de alta expresión de acuaporina-4. Caso 1: varón de 50 años, que comenzó con pérdida de visión en ojo derecho (OD. Recibió tratamiento empírico con metilprednisolona 1 g/d x 3 días. Al mes presentó dolor generalizado y hemiparesia derecha; nuevamente recibió metilprednisolona 1 g/d x 5 días e IgG IV 400 mg/kg/d × 5 días. Recuperó la deambulación persistiendo el dolor y fenómenos paroxísticos en los 4 miembros. Potenciales evocados visuales: P100, ojo izquierdo (OI 123 mseg. OD sin respuesta. La RM de cerebro (FLAIR mostró hiperintensidad en nervio óptico derecho, hipotálamo y comisura blanca anterior. RM cervical: lesión medular extensa (5 cuerpos vertebrales. Caso 2: mujer de 53 años, con disminución de la agudeza visual en ambos ojos y parestesias en miembros inferiores que remitieron espontáneamente. Evolucionó al mes con cuadriparesia e incontinencia esfinteriana. Recibió metilprednisolona 1 g/d x 5 días, sin mejoría. Potenciales evocados visuales: P100 OI 124 mseg. OD 128 mseg. RM cerebro: (FLAIR hiperintensidad hipotalámica y periacueductal. RM cervical: lesión medular extensa (7 cuerpos vertebrales. Anticuerpos anti-acuaporina-4 positivos en ambos pacientes (inmunofluorescencia indirecta. Las lesiones consideradas "atípicas", como aquí, en sitios con alta densidad de proteínas canales de agua AQP4 deberán considerarse para el diagnóstico diferencial.

  18. Propiedades mecánicas del telururo de bismuto (Bi2Te3 procesado mediante torsión bajo alta presión (HPT

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    Santamaría, Jon Ander

    2013-06-01

    Full Text Available Bismuth telluride, Bi2Te3, is the main thermoelectric material currently in use for commercial cooling devices or for energy harvesting near room temperature. Because of its highly anisotropic layered structure, Bi2Te3 is very brittle, failing by cleavage along its basal plane. Refining its grain size is expected to increase its toughness with the advantage that, simultaneously, its thermoelectric “figure of merit” results increased. In this work, powders of the compound have been compacted by conventional methods as well as by severe plastic deformation under high pressure (3 GPa using high pressure torsion (HPT, one turn at room temperature. Near-theoretical density has been achieved. The hardness and toughness of the compacts have been assessed by micro and nano-indentation.Actualmente el telururo de bismuto (Bi2Te3 es el material termoeléctrico más ampliamente usado en sistemas de refrigeración comerciales o en la conversión de energía en torno a temperatura ambiente. Debido a su estructura laminar altamente anisótropa, el Bi2Te3 es muy frágil y suele agrietarse fácilmente a lo largo de su plano basal. Se espera que el afino del tamaño de grano incremente su tenacidad, con la ventaja de que al mismo tiempo la figura de mérito termoeléctrica se vea incrementada. En este trabajo, polvos del compuesto Bi2Te3 se han compactado mediante dos métodos convencionales y mediante deformación plástica severa bajo alta presión (3 GPa usando la técnica HPT (torsión a alta presión, 1 giro de deformación. Se ha conseguido una densidad cercana a la teórica. La dureza y tenacidad de los compuestos se han ensayado mediante micro- y nano- indentación.

  19. MICROTOMOGRAFIA DE ALTA RESOLUÇÃO NO SETOR MINERAL

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    Daniel Uliana

    2014-07-01

    Full Text Available A técnica de microscopia por tomografia de raios X (MRX oferece uma capacidade única para análise de associações, morfologia e liberação de múltiplas fases através da aquisição direta de imagens tridimensionais de alta resolução. Trata-se de uma técnica de análise 3D não invasiva atualmente utilizada no setor mineral para caracterização de carvão, minerais industriais e de base, além de metais preciosos, complementando técnicas de microscopia já existentes como MLA e QEMSCAN. A técnica já é empregada há algum tempo na indústria do petróleo para a caracterização de tamanho e distribuição de poros, permitindo simular o fluxo de óleo em rochas reservatório. Além disso, a caracterização de poros em 3D permite a simulação de fluxo em processos de lixiviação. Requerendo pouca ou nenhuma preparação da amostra, comparativamente às técnicas de microscopia bi ou unidimensionais proporciona vantagens como a preparação muito mais ágil da amostra, aquisição direta de dados volumétricos, análise quantitativa em 3D e menor tempo de análise aliado a maior representatividade do material analisado. Particularmente em estudos de metais preciosos, tem-se um significativo aumento na probabilidade de detecção dos minerais de interesse. Recentes avanços com o emprego de dupla magnificação – projeção cônica aliada à utilização de lentes ópticas - possibilitam a aquisição de imagens com resolução submicrométrica com sensível melhoria no contraste entre as fases.

  20. Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial.

    Science.gov (United States)

    Farràs, Marta; Fernández-Castillejo, Sara; Rubió, Laura; Arranz, Sara; Catalán, Úrsula; Subirana, Isaac; Romero, Mari-Paz; Castañer, Olga; Pedret, Anna; Blanchart, Gemma; Muñoz-Aguayo, Daniel; Schröder, Helmut; Covas, Maria-Isabel; de la Torre, Rafael; Motilva, Maria-José; Solà, Rosa; Fitó, Montserrat

    2018-01-01

    At present, high-density lipoprotein (HDL) function is thought to be more relevant than HDL cholesterol quantity. Consumption of olive oil phenolic compounds (PCs) has beneficial effects on HDL-related markers. Enriched food with complementary antioxidants could be a suitable option to obtain additional protective effects. Our aim was to ascertain whether virgin olive oils (VOOs) enriched with (a) their own PC (FVOO) and (b) their own PC plus complementary ones from thyme (FVOOT) could improve HDL status and function. Thirty-three hypercholesterolemic individuals ingested (25 ml/day, 3 weeks) (a) VOO (80 ppm), (b) FVOO (500 ppm) and (c) FVOOT (500 ppm) in a randomized, double-blind, controlled, crossover trial. A rise in HDL antioxidant compounds was observed after both functional olive oil interventions. Nevertheless, α-tocopherol, the main HDL antioxidant, was only augmented after FVOOT versus its baseline. In conclusion, long-term consumption of phenol-enriched olive oils induced a better HDL antioxidant content, the complementary phenol-enriched olive oil being the one which increased the main HDL antioxidant, α-tocopherol. Complementary phenol-enriched olive oil could be a useful dietary tool for improving HDL richness in antioxidants. Copyright © 2017. Published by Elsevier Inc.

  1. Isolated low high density lipoprotein-cholesterol (HDL-C: implications of global risk reduction. Case report and systematic scientific review

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    Tyagi Suresh C

    2005-01-01

    Full Text Available Abstract Background The importance of low high-density lipoprotein cholesterol (HDL-C, elevated non HDL-C (as part of the metabolic syndrome, prediabetes, and type 2 diabetes mellitus, and an isolated low HDL-C is rapidly emerging. The antiatherosclerotic roles of reverse cholesterol transport and the pleiotropic antioxidant – anti-inflammatory mechanistic effects of HDL-C are undergoing rapid exponential growth. Case presentation In 1997 a 53-year-old Caucasian male presented with a lipoprotein profile of many years duration with an isolated low HDL-C and uric acid levels in the upper quintile of normal. He developed an acute myocardial infarction involving the right coronary artery and had percutaneous transluminal coronary angioplasty with stenting of this lesion. He also demonstrated a non-critical non-flow limiting lesion of the proximal left anterior descending coronary artery at the time of this evaluation. Following a program of global risk reduction this patient has done well over the past 7 years and remains free of any clinical signs and symptoms of atherosclerosis. His HDL-C and uric acid levels are currently in the normal physiological range. Conclusion Low HDL-C and isolated low HDL-C constitute an important risk factor for atherosclerosis. Therapies that lead to a return to normal physiologic range of HDL-C may result in the delay of atherosclerotic progression.

  2. A Novel Antisense CAG Repeat Transcript at JPH3 Locus Mediating Expanded Polyglutamine Protein Toxicity in Huntington’s Disease-Like 2 (HDL2) Mice

    Science.gov (United States)

    Wilburn, Brian; Rudnicki, Dobrila D.; Zhao, Jing; Weitz, Tara Murphy; Cheng, Yin; Gu, Xiaofeng; Greiner, Erin; Park, Chang Sin; Wang, Nan; Sopher, Bryce L.; La Spada, Albert R.; Osmand, Alex; Margolis, Russell L.; Sun, Yi E.; Yang, X. William

    2011-01-01

    SUMMARY Huntington’s disease like-2 (HDL2) is a phenocopy of Huntington’s disease caused by CTG/CAG repeat expansion at the Junctophilin-3 (JPH3) locus. The mechanisms underlying HDL2 pathogenesis remain unclear. Here we developed a BAC transgenic mouse model of HDL2 (BAC-HDL2) that exhibits progressive motor deficits, selective neurodegenerative pathology and ubiquitin-positive nuclear inclusions (NIs). Molecular analyses reveal a novel promoter at the transgene locus driving the expression of a CAG repeat transcript (HDL2-CAG) from the strand antisense to JPH3, which encodes an expanded polyglutamine (polyQ) protein. Importantly, BAC-HDL2 but not control BAC mice accumulate polyQ-containing NIs in a pattern strikingly similar to those in the patients. Furthermore, BAC mice with genetic silencing of the expanded CUG transcript still express HDL2-CAG transcript and manifest polyQ pathogenesis. Finally, studies of HDL2 mice and patients revealed CBP sequestration into NIs and evidence for interference of CBP-mediated transcriptional activation. These results suggest overlapping polyQ-mediated pathogenic mechanisms in HD and HDL2 PMID:21555070

  3. Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus

    DEFF Research Database (Denmark)

    Paulmichl, Katharina; Hatunic, Mensud; Højlund, Kurt

    2016-01-01

    BACKGROUND: The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids are components of other insulin-sensitivity indices but thei......BACKGROUND: The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids are components of other insulin-sensitivity indices...

  4. Importância da HDL-c para a ocorrência de doença cardiovascular no idoso La importancia del HDL-c para la ocurrencia de la enfermedad cardiovascular en el adulto mayor Importance of HDL-c for the occurrence of cardiovascular disease in the elderly

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    Elizabete Viana de Freitas

    2009-09-01

    Full Text Available FUNDAMENTO: Estudos sobre o impacto da HDL-c e ocorrência de doença cardiovascular (CV em idosos são escassos. OBJETIVO: Avaliar as variáveis clínicas e laboratoriais e a ocorrência de eventos CV em idosos estratificados de acordo com o comportamento da HDL-c em seguimento de oito anos. MÉTODOS: Foram avaliados, em dois momentos (A1 e A2, com espaço mínimo de cinco anos, 81 idosos, com idade média de 68,51 ± 6,32 (38,2% do sexo masculino. Os indivíduos foram divididos em 3 grupos de acordo com o nível da HDL-c: HDL-c normal nas duas avaliações (GN (n=31; HDL-c baixa nas duas avaliações (GB (n=21; e HDL-c variável de A1 para A2 (GV (n=29. Foram registrados os eventos CV maiores: doença coronariana (angina, infarto miocárdio, revascularização miocárdica percutânea/cirúrgica, acidente vascular encefálico, acidente isquêmico transitório, doença carotídea, demência e insuficiência cardíaca. RESULTADOS: Os grupos não diferiram quanto à idade e sexo em A1 e A2. As médias dos triglicérides foram menores no GN em A1 (p=0,027 e A2 (p=0,016 que no GB. Já a distribuição de eventos CV foi de 13 eventos no GN (41,9%, 16 (76,2% no GB e de 12 (41,4% no GV (χ2=7,149, p=0,024. Em análise de regressão logística observou-se que quanto maior a idade (OR=1,187, p=0,0230 e quanto menor a HDL-c (OR=0,9372, p=0,0102, maior a ocorrência de eventos CV. CONCLUSÃO: O HDL-c permanentemente baixo ao longo de oito anos de acompanhamento foi fator de risco para desenvolvimento de eventos CV em idosos.FUNDAMENTO: Estudios sobre el impacto del HDL-c y ocurrencia de enfermedad cardiovascular (CV en adultos mayores son raros. OBJETIVO: Evaluar las variables clínicas y laboratoriales y la ocurrencia de eventos CV en adultos mayores estratificados según el comportamiento del HDL-c en seguimiento de ocho años. MÉTODOS: Se evaluaron, en dos momentos (A1 y A2, con espacio mínimo de cinco años, a 81 adultos mayores, con edad promedio de

  5. Basic density and pulp yield relationship with some chemical parameters in eucalyptus trees Densidade e rendimento em polpa celulósica e sua relação com alguns parâmetros químicos no eucalipto

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    Ana Maria Loureiro da Seca

    2006-12-01

    /guaiacilo (S/G e seringaldeído/vanilina (S/V. As amostras dos quartis de alta densidade e as de baixo rendimento foram semelhantes, ambas com baixos valores de S/V (3,99-4,09 e S/G (3,88-4,12 e os mais elevados teores de fenóis totais (13,3-14,3 g de ácido gálico por quilograma. As madeiras do quarto quartil de rendimento são estatisticamente distintas das outras, com as maiores razões S/G (5,15 e S/V (4,98 e os menores teores de fenóis totais (8,7 g de ácido gálico por quilograma. Os parâmetros grupos metoxílicos e açúcares totais são os mais adequados para a diferenciação das amostras provenientes do primeiro quartil de densidade.

  6. Correlação linear e espacial entre produtividade de Brachiaria brizantha, densidade do solo e porosidade total em função do sistema de manejo do solo Linear and spatial correlations among forage yield, bulk density and total porosity in function of soil management system

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    Edney L. da Vitória

    2012-10-01

    Full Text Available A densidade e a porosidade são propriedades físicas do solo que são alteradas em função do sistema de manejo utilizado, com consequente influência sobre a produtividade das culturas. A produtividade da planta forrageira, Brachiaria brizantha, em função da densidade do solo e da porosidade total foi analisada em dois sistemas de manejo de solo, em experimento conduzido no segundo semestre de 2009, no município de Santa Teresa, no Estado do Espírito Santo. O objetivo foi estudar a variabilidade e as correlações lineares e espaciais entre os atributos da planta e do solo, visando a selecionar um indicador da qualidade física do solo de boa representatividade para produtividade de forragem. Marcaram-se duas parcelas de 40 m por 50 m a cada 5 m, em duas direções, resultando em um reticulado retangular de 99 pontos, em cada um dos sistemas utilizados: preparo convencional e plantio direto. Os atributos estudados, além de não terem variado aleatoriamente, apresentaram variabilidade dos dados entre média e alta, e seguiram padrões espaciais bem definidos, com alcance entre 20,3 e 24,2 m. Por sua vez, a correlação linear entre o atributo da planta e os do solo, em função do elevado número de observações, foi baixa. A melhor correlação para produtividade de matéria seca foi com a densidade do solo na profundidade de 0,0 - 0,15 m, independentemente do sistema de manejo do solo, indicando que a produtividade e a densidade do solo são inversamente proporcionais. Portanto, a densidade do solo avaliada na camada de 0,0 - 0,15 m apresentou-se como satisfatório indicador da qualidade física do solo, quando se considerou a produtividade da forrageira.Total porosity and bulk density are strongly affected by soil management, which reflects directly in agricultural productivity. The productivity of the forage, Brachiaria brizantha, in function of bulk density and total porosity was analyzed in two soil management systems, in an

  7. Efeitos da atividade física na densidade mineral óssea e na remodelação do tecido ósseo Efectos de la actividad física en la densidad mineral ósea y en la remodelacion del tejido óseo Effects of the physical activity on the bone mineral density and bone remodelation

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    Eduardo Lusa Cadore

    2005-12-01

    Full Text Available Este artigo revisa os efeitos de diferentes modalidades esportivas e do treinamento de força na remodelação óssea e discutir as possíveis relações da densidade mineral óssea (DMO com a força muscular e a composição corporal. Numerosos estudos indicam que a atividade física de alto impacto, ou que exija alta produção de força, pode ter um efeito benéfico na DMO, devido à deformação desse tecido, ocorrida durante a atividade. Alguns autores têm avaliado os efeitos do treinamento físico em alguns marcadores bioquímicos da remodelação óssea, já que a variação das concentrações desses marcadores pode indicar um estado de formação ou reabsorção óssea. Entretanto, a inconsistência dos resultados encontrados sugere que a análise dos efeitos da atividade física na remodelação óssea, através desses marcadores, deve ser mais investigada. Existem muitas discrepâncias a respeito da relação entre a DMO com a força muscular e a composição corporal, principalmente na determinação de qual desses fatores está mais associado com a DMO. A determinação de qual o tipo de atividade física seja ideal para aumentar o pico de massa óssea na adolescência, ou mesmo mantê-la após a idade adulta, é muito importante para a prevenção e o possível tratamento da osteoporose.Este artículo busca revisar los efectos de modalidades deportivas diferentes y del entrenamiento de fuerza en la remodelación del hueso y discutir las posibles relaciones entre la densidad mineral del hueso (DMO con la fuerza muscular y la composición corporal. Los numerosos estudios indican que la actividad física de alto impacto o que exige producción alta de fuerza, pueden tener un efecto beneficioso en la DMO, debido a la deformación que ese tejido, pasa durante la actividad física. Algunos autores han estado evaluando los efectos de la educación física en algunos marcadores bioquímicos de la remodelación del hueso, desde la variaci

  8. Demografia e densidade de perfilhos de capim-braquiária sob pastejo em lotação intermitente

    Directory of Open Access Journals (Sweden)

    Jorge Nunes Portela

    2011-03-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos de intensidades de pastejo e de frequências de desfolha na demografia e densidade de perfilhos de capim-braquiária (Urochloa decumbens syn. Brachiaria decumbens sob lotação intermitente. Foram avaliados duas intensidades de pastejo (5 e 10 cm de altura pós-pastejo e duas frequências de desfolha (período de descanso até que o dossel atingisse 95 e 100% de interceptação luminosa, IL, de agosto de 2007 a agosto de 2008. Utilizou-se o delineamento inteiramente casualizado, em arranjo fatorial com quatro repetições. Avaliaram-se as densidades populacionais e as taxas de aparecimento e sobrevivência de perfilhos basais (DPPb, TAPb e TSPb, respectivamente e aéreos+basais (DPPab, TAPab e TSPab. As maiores TAPb e TAPab, no outono, foram obtidas nos pastos desfolhados a 10 cm. Porém, no final da primavera e no verão, a intensidade de 5 cm resultou em maiores taxas, que promoveram maior DPPb. No verão, a TSPb foi maior para pastos manejados à intensidade de 10 cm. O manejo da pastagem que resulta em maiores DPPab, TAPab e TSPab, durante as épocas de rápido crescimento dos pastos, é o de 10 cm de intensidade de pastejo e 95% de IL de frequência de desfolha.

  9. Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades

    Science.gov (United States)

    Cirigliano, D.; Vial, J. C.; Rovira, M.

    A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

  10. Planting density and yield of cassava roots Densidade de plantio e rendimento de raízes de mandioca

    Directory of Open Access Journals (Sweden)

    Tiago Santos Silva

    2013-06-01

    Full Text Available In Mata Fresca, an area located on the border of the states of Rio Grande do Norte and Ceará, in Brazil, small farmers have a source of income from the production of cassava roots, using planting densities of around 5,000 plants ha-1. This procedure might be helping to limit higher yields of the roots, since some studies have shown that it is possible to obtain higher yields of cassava using higher densities. The objective of this study was to evaluate the root yield and other characteristics of the cassava, as a response to planting density. The Vermelhinha cultivar was submitted to planting densities of from 5,000 to 21,000 plants ha-1, at intervals of 2,000 plants ha-1, in an experiment under irrigation. A completely randomized block design with four replications was used. The ideal planting densities in order to maximise leaf green matter, stems and branches, total roots, total marketable roots, number of marketable roots, marketable-root dry matter and stem dry matter, were 17,800; 17,077; 14,416; 13,594; 16,436; 12,361; and 18,149 plants ha-1 respectively. When adopting the planting density used by the farmers, a yield for marketable roots of 15,837 kg ha-1 was obtained. By using the optimal density as found in this work (13,594 plants ha-1, the yield was more than double that of the farmers. Increasing planting density reduced both the length of the marketable roots and the harvest index (the ratio of marketable-root dry matter to total plant dry matter.Na Mata Fresca, área situada na divisa dos Estados do Rio Grande do Norte e Ceará, pequenos agricultores têm como fonte de renda a obtida com a produção de raízes de mandioca, usando densidades de plantio em torno de 5.000 plantas ha-1. Esse procedimento pode estar limitando a obtenção de maiores rendimentos de raízes, pois alguns trabalhos demonstraram que é possível a obtenção de rendimentos maiores da mandioca, com maiores densidades. O objetivo do trabalho foi avaliar o

  11. Prácticas de Física: Medición de masas. Determinación de densidades con la balanza hidrostática

    OpenAIRE

    Beléndez, Augusto; Bernabeu, Guillermo; Vera Guarinos, Jenaro; Pastor Antón, Carlos; Martín García, Agapito

    1988-01-01

    El objetivo de esta práctica es conocer los distintos métodos de pesada y el empleo del método de la tara constante para determinar la densidad de líquidos y sólidos con la balanza hidrostática, utilizando un líquido patrón. Se trata de obtener la densidad de un líquido utilizando un picnómetro y un líquido de referencia (agua destilada). Se determinará primero la masa del picnómetro lleno de agua destilada y después lleno con el líquido problema. Se obtendrá la densidad relativa del líquido ...

  12. Estudo da densidade óssea na esclerodermia sistêmica Bone density in systemic sclerosis (scleroderma patients

    Directory of Open Access Journals (Sweden)

    H.C. da Silva

    1997-03-01

    Full Text Available OBJETIVO. A osteopenia em pacientes com esclerodermia sistêmica foi descrita, radiologicamente, em mãos e, por densidade óssea, no terço proximal e distal do rádio. A redução da massa óssea, nesses pacientes, tem sido atribuída à isquemia, imobilização e à menopausa precoce. O objetivo deste estudo é analisar a densidade óssea na coluna, região proximal do fêmur e corpo todo de pacientes com esclerodermia sistêmica. PACIENTES E MÉTODO. Foram examinadas 25 pacientes caucasóides, sem outras condições que pudessem afetar o metabolismo ósseo. A média de idade das pacientes foi de 48 ± 12 anos, e o tempo de doença, de 7 ± 7 anos; 13 estavam na pós-menopausa há 8 ± 8 anos. A medida de massa óssea foi realizada na coluna, região proximal do fêmur e corpo todo, utilizando-se densitômetro de dupla emissão com fonte de raios X (Lunar - modelo DPX. RESULTADOS. Não houve diferença estatisticamente significante na densidade óssea das regiões avaliadas nas pacientes com esclerodermia sistêmica e as mulheres-controle pareadas para a idade, peso, altura e anos de menopausa. A densidade óssea das pacientes com forma limitada não foi diferente daquelas com a forma difusa. Pacientes com calcinose apresentaram menor densidade óssea na região proximal do fêmur que aquelas sem calcinose. CONCLUSÕES. Os autores concluíram que pacientes com esclerodermia sistêmica não apresentam perda de massa óssea. Portanto, a esclerodermia não é um fator de risco para o desenvolvimento de osteoporose generalizada.BACKGROUND - Osteopenia in systemic sclerosis (scleroderma patients was reported in X-ray studies of hands and by proximal and distal forearm bone mass measurement. It has been suggested that bone loss in these patients might be due to chronic ischemia, immobilization and early menopause. Nevertheless it is not established if these patients present generalized osteopenia. To shed light into this point we studied bone

  13. Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS

    Science.gov (United States)

    Previous analysis clustered 1,238 individuals from the general population Genetics of Lipid Lowering Drugs Network (GOLDN) study by the size of their fasting very low-density, low-density and high-density lipoproteins (VLDL, LDL, HDL) using latent class analysis. From two of the eight identified gro...

  14. Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk

    DEFF Research Database (Denmark)

    Nordestgaard, Børge G; Tybjærg-Hansen, Anne

    2011-01-01

    To evaluate whether new and known genetic determinants of plasma levels of LDL cholesterol, lipoprotein(a), triglyceride-rich lipoproteins, and HDL cholesterol associate with the risk of cardiovascular disease expected from the effect on lipoprotein levels. Concordance or discordance...

  15. Gender-dependent association of HSD11B1 single nucleotide polymorphisms with glucose and HDL-C levels

    Directory of Open Access Journals (Sweden)

    Luciane Viater Turek

    2014-09-01

    Full Text Available In this study, we investigated the influence of two SNPs (rs846910 and rs12086634 of the HSD11B1 gene that encodes 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1, the enzyme that catalyzes the conversion of cortisol to cortisone, on variables associated with obesity and metabolic syndrome in 215 individuals of both sexes from southern Brazil. The HSD11B1 gene variants were genotyped using the TaqMan SNP genotyping assay. Glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were measured by standard automated methods. Significant results were found in women, with carriers of the G allele of SNP rs12086634 having higher glucose levels than non-carriers. Carriers of the A allele of SNP rs846910 had higher levels of HDL-cholesterol. The involvement of both polymorphisms as independent factors in determining the levels of glucose and HDL-cholesterol was confirmed by multiple regression analysis (β = 0.19 ± 0.09, p = 0.03 and β = 0.22 ± 0.10, p = 0.03, respectively. Our findings suggest that the HSD11B1SNPs studied may indirectly influence glucose and HDL-cholesterol metabolism in women, possibly through down-regulation of the HSD11B1 gene by estrogen.

  16. Effect of theobromine consumption on serum lipoprotein profiles in apparently healthy humans with low HDL-cholesterol concentrations

    NARCIS (Netherlands)

    Jacobs, Doris M.; Smolders, Lotte; Lin, Yuguang; Roo, de Niels; Trautwein, Elke A.; Duynhoven, van John; Mensink, Ronald P.; Plat, Jogchum; Mihaleva, Velitchka V.

    2017-01-01

    Scope: Theobromine is a major active compound in cocoa with allegedly beneficial effect on high-density-lipoprotein-cholesterol (HDL-CH). We have investigated the effect of theobromine (TB) consumption on the concentrations of triglyceride (TG) and cholesterol (CH) in various lipoprotein (LP)

  17. Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe

    NARCIS (Netherlands)

    M.L. Bots (Michiel); D.E. Grobbee (Diederick); P.C. Elwood; Y. Nikitin; J.T. Salonen; A. Freire de Concalves; D. Inzitari; J. Sivenius; V. Benetou (Vassiliki); J. Tuomilehto; P.J. Koudstaal (Peter Jan)

    2002-01-01

    textabstractBACKGROUND: Controversy remains on the relation between serum lipids levels and stroke risk. This paper investigated the association of total and HDL cholesterol level to fatal and non-fatal, and haemorrhagic and ischaemic stroke in four European cohorts participating

  18. Effect of Animal and Industrial Trans Fatty Acids on HDL and LDL Cholesterol Levels in Humans - A Quantitative Review

    NARCIS (Netherlands)

    Brouwer, I.A.; Wanders, A.J.; Katan, M.B.

    2010-01-01

    Background: Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower HDL cholesterol, raise LDL cholesterol, and increase the risk of coronary heart disease. The effects of conjugated linoleic acid

  19. Mutations in the gene for lipoprotein lipase. A cause for low HDL cholesterol levels in individuals heterozygous for familial hypercholesterolemia

    NARCIS (Netherlands)

    Pimstone, S. N.; Gagné, S. E.; Gagné, C.; Lupien, P. J.; Gaudet, D.; Williams, R. R.; Kotze, M.; Reymer, P. W.; Defesche, J. C.; Kastelein, J. J.

    1995-01-01

    Familial hypercholesterolemia (FH) is characterized by elevated plasma concentrations of LDL cholesterol resulting from mutations in the gene for the LDL receptor. Low HDL cholesterol levels are seen frequently in patients both heterozygous and homozygous for mutations in this gene. Suggested

  20. Densidad de siembra y fertilización nitrogenada en trigo : 1-cultivares Marcos Juárez INTA y Norkinpan 70

    OpenAIRE

    Lerner, Silvia Elena; Mac Maney, Miguel; Tapia, M. R.

    1986-01-01

    p.9-16 Se presenta en este trabajo la respuesta de dos cultivares de trigo de ciclo corto, ante variaciones en la densidad de siembra y en nutrición nitrogenada. Se utilizaron dos densidades de siembra (300 y 600 pl-m2) y una fertilización con urea a mediados de macollaje (150 kg-ha). En momentos preestablecidos del ciclo del cultivo se realizaron cortes para medición de biomasa, área foliar y componentes del rendimiento: espigas por metro cuadrado, granos por espiga y peso de los granos. ...

  1. Desarrollo de un sistema de suspensión magnética para la determinación de densidad de líquidos

    OpenAIRE

    Centeno González, Luz María; Castillo Castañeda, Eduardo; Becerra Santiago, Luis Omar; Rochín García, Alberto

    2013-01-01

    La densidad es una magnitud derivada de las magnitudes de base masa y longitud, está definida como masa por unidad de volumen y su unidad en el Sistema Internacional de Unidades (SI) es el kg/m3. En las últimas cinco décadas, en el ámbito de la metrología primaria, se han desarrollado sistemas de suspensión magnética para la determinación de densidad de fluidos, lo que ha permitido realizar investigaciones sobre las características físicas de líquidos y gases. El presente trabajo tiene como o...

  2. Moderate dyslipoproteinemia induced inflammation and remodeling HDL and VLDL particles in post-renal transplant patients

    Directory of Open Access Journals (Sweden)

    Kimak Elzbieta

    2017-06-01

    Full Text Available The aim of this paper was to examine whether moderate dyslipoproteinemia can cause an increase of hsCRP and LPO levels in Tx patients who had received immunosuppressive therapy and were without acute inflammatory diseases. Herein, the lipid levels, hsCRP, LPO, apolipoprotein (apoB, AI, AII, AIInonB, apoB-containing AII (apoB:AII, apoCIII, apoCIIInonB, apoB:CIII, LCAT level, as well as CETP and PON1 activity were determined. All examined Tx patients had moderate dyslipidemia and slightly increased hsCRP, LPO, apoB:AII and apoCIII levels, but decreased LCAT mass, PON1 activity and lipoprotein ratios. Tx patients with apoAI150mg/dl (n=39, but no difference in CETP activity was indicated. Multiple ridge forward regression and Spearman’s correlation test were used. The results of the presented study, show for the first time that higher apoAI/apoB and apoAI/apoCIII ratios induced a decrease of the hsCRP concentration. Moreover, the composition of apoCIIInonB, LDL-C and apoAI brought about an increase of LCAT mass and PON1 activity. In Tx patients with lower concentration of apoAI, an increase of concentration of apoB:AII in VLDL generated a mild oxidation of lipoprotein and an elevated concentration of LPO. However, lower ApoAI/apoB ratio resulted in an increase of PON1 activity and apoB, as well as nonHDL-C levels, and in turn, PON1 activity increased LCAT mass. These disorders rearranged the HDL particle, and, simultaneously, remodeled the VLDL particle. This may prevent antioxidant activity, reverse cholesterol transport and accelerate the rejection of the transplant, as well as bringing about cardiovascular diseases in Tx patients with lower apoAI. Such metabolic pathways can be used as potentially novel targets for pharmacological intervention.

  3. Aislamiento e identificación de hongos asociados a esclerocios de Sclerotium cepivorum, causante de la pudrición blanca de la cebolla, en la zona alta de Cartago, Costa Rica

    Directory of Open Access Journals (Sweden)

    María del Milagro Granados

    2005-01-01

    Full Text Available Se aislaron e identificaron hongos asociados a esclerocios de Sclerotium cepivorum, causante de la pudrición blanca de la cebolla, con el fin de determinar la existencia de hongos con potencial antagónico nativos en la zona alta de Cartago. Se estudiaron 10 fincas durante febrero-mayo de 2002. Cada una se dividió en 3 áreas de acuerdo al nivel de incidencia histórica de la enfermedad (bajo, intermedio, alto. En cada área se realizó un trampeo de hongos mediante la técnica de entierro de esclerocios; además se hizo muestreo de plantas enfermas, se colectó suelo para cuantificar densidad de inóculo y para realizar análisis microbiológicos, químico sencillo, de textura y determinación de materia orgánica. Los géneros encontrados en el trampeo fueron Alternaria spp., Fusarium spp., Gliocladium sp., Mucor sp., Penicillium spp., Rhizoctonia sp., Rhizopus sp. y Trichoderma spp.; en bulbos enfermos se aislaron Fusarium spp., Monilia sp., Mucor sp., Penicillium spp., Pythium sp., Rhizopus sp., y Trichoderma spp. Los géneros Gliocladium sp., Penicillium spp. y Trichoderma spp. también se hallaron en el análisis microbiológico de suelo. Las poblaciones más altas de microorganismos se recuperaron en el área intermedia de todas las fincas. Este trabajo comprueba que es posible aislar hongos con potencial antagónico, como Trichoderma spp., Gliocladium sp. y Paecilomyces sp., en suelos a los que por muchos años se les ha aplicado una gran cantidad de fungicidas.

  4. LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.

    Science.gov (United States)

    Kannisto, Kristina; Gåfvels, Mats; Jiang, Zhao-Yan; Slätis, Katharina; Hu, Xiaoli; Jorns, Carl; Steffensen, Knut R; Eggertsen, Gösta

    2014-01-01

    We investigated whether: (1) liver X receptor (LXR)-driven induction of high-density lipoprotein cholesterol (HDL-C) and other LXR-mediated effects on cholesterol metabolism depend on intestinal cholesterol absorption; and (2) combined treatment with the LXR agonist GW3965 and the cholesterol absorption inhibitor ezetimibe results in synergistic effects on cholesterol metabolism that could be beneficial for treatment of atherosclerosis. Mice were fed 0.2 % cholesterol and treated with GW3965+ezetimibe, GW3965 or ezetimibe. GW3965+ezetimibe treatment elevated serum HDL-C and Apolipoprotein (Apo) AI, effectively reduced the intestinal cholesterol absorption and increased the excretion of faecal neutral sterols. No changes in intestinal ATP-binding cassette (ABC) A1 or ABCG5 protein expression were observed, despite increased mRNA expression, while hepatic ABCA1 was slightly reduced. The combined treatment caused a pronounced down-regulation of intestinal Niemann-Pick C1-like 1 (NPC1L1) and reduced hepatic and intestinal cholesterol levels. GW3965 did not affect the intestinal cholesterol absorption, but increased serum HDL-C and ApoAI levels. GW3965 also increased Apoa1 mRNA levels in primary mouse hepatocytes and HEPA1-6 cells. Ezetimibe reduced the intestinal cholesterol absorption, ABCA1 and ABCG5, but did not affect the serum HDL-C or ApoAI levels. Thus, the LXR-driven induction of HDL-C and ApoAI was independent of the intestinal cholesterol absorption and increased expression of intestinal or hepatic ABCA1 was not required. Inhibited influx of cholesterol via NPC1L1 and/or low levels of intracellular cholesterol prevented post-transcriptional expression of intestinal ABCA1 and ABCG5, despite increased mRNA levels. Combined LXR activation and blocked intestinal cholesterol absorption induced effective faecal elimination of cholesterol.

  5. Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase.

    Science.gov (United States)

    Simic, Branko; Mocharla, Pavani; Crucet, Margot; Osto, Elena; Kratzer, Adelheid; Stivala, Simona; Kühnast, Susan; Speer, Thimoteus; Doycheva, Petia; Princen, Hans M; van der Hoorn, Jose W; Jukema, J Wouter; Giral, Hector; Tailleux, Anne; Landmesser, Ulf; Staels, Bart; Lüscher, Thomas F

    2017-02-01

    High-density lipoprotein cholesterol (HDL-C) is inversely related to cardiovascular risk. HDL-C raising ester transfer protein (CETP) inhibitors, are novel therapeutics. We studied the effects of CETP inhibitors anacetrapib and evacetrapib on triglycerides, cholesterol and lipoproteins, cholesterol efflux, paraoxonase activity (PON-1), reactive oxygen species (ROS), and endothelial function in E3L and E3L.CETP mice. Triglycerides and cholesterol were measured at weeks 5, 14 and 21 in E3L.CETP mice on high cholesterol diet and treated with anacetrapib (3 mg/kg/day), evacetrapib (3 mg/kg/day) or placebo. Cholesterol efflux was assessed ex-vivo in mice treated with CETP inhibitors for 3 weeks on a normal chow diet. Endothelial function was analyzed at week 21 in isolated aortic rings, and serum lipoproteins assessed by fast-performance liquid chromatography. Anacetrapib and evacetrapib increased HDL-C levels (5- and 3.4-fold, resp.) and reduced triglycerides (-39% vs. placebo, p = 0.0174). Total cholesterol levels were reduced only in anacetrapib-treated mice (-32%, p = 0.0386). Cholesterol efflux and PON-1 activity (+45% and +35% vs. control, p < 0.005, resp.) were increased, while aortic ROS production was reduced with evacetrapib (-49% vs. control, p = 0.020). Anacetrapib, but not evacetrapib, impaired endothelium dependent vasorelaxation (p < 0.05). In contrast, no such effects were observed in E3L mice for all parameters tested. Notwithstanding a marked rise in HDL-C, evacetrapib did not improve endothelial function, while anacetrapib impaired it, suggesting that CETP inhibition does not provide vascular protection. Anacetrapib exerts unfavorable endothelial effects beyond CETP inhibition, which may explain the neutral results of large clinical trials in spite of increased HDL-C. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender

    Directory of Open Access Journals (Sweden)

    Hamit Yasar Ellidag

    2016-12-01

    Full Text Available Elevated serum ferritin (SFer levels have been associated with chronic diseases such as coronary heart disease and diabetes mellitus type 2. The aim of this study was to examine the relationship between SFer levels and serum lipid parameters, and how this relation changes in terms of age and gender. Additionally, we investigated a possible relationship between SFer levels and high-density lipoprotein (HDL function. SFer levels and lipid panel (total cholesterol (TC, triglyceride (TG, low-density lipoprotein-cholesterol (LDL-C and HDL-C of 4205 people (3139 women, 1066 men were examined retrospectively. Study population was classified according to age and gender. Separately, 100 subjects (52 women, 48 men were randomly recruited to investigate the relation between SFer levels, and HDL dependent paraoxonase-1 (PON1 and arylesterase (ARE activities. In all age groups, women’s SFer levels were found to be significantly lower and HDL-C levels significantly higher compared to men. In the 50-70 ages range, TC and LDL-C levels of women were found to be significantly higher than those of men (P < 0.01. SFer levels tended to increase with age in women. Correlation analyses revealed a negative correlation between levels of SFer and HDL-C, while positive correlations existed between levels of SFer, and TC, TG and LDL-C. There was no significant correlation between SFer levels and PON1 or ARE activities. The finding that increased SFer levels are accompanied by increased serum TC, TG and LDL-C levels may help us to explain the increased risk of metabolic disorders and cardiovascular disease in postmenopausal women.

  7. A Preliminary Verification and Validation (V and V) Methodology for the Artifacts Programmed with a Hardware Description Language (HDL)

    International Nuclear Information System (INIS)

    Suh, Yong Suk; Keum, Jong Yong; Park, Je Youn; Jo, Ki Ho; Jo, Chang Whan

    2008-01-01

    Nowadays, the FPGA (Field Programmable Gate Array) is widely used in various fields of industry. The FPGA was evolved from the technology of PLD (Programmable Logic Device). The FPGA provides more logic gates than the PLD, which integrates millions of programmable logic gates into a chip. It also provides a massive, fast and reliable processing performance. So, we can integrate a system's functions into a FPGA, which can be a SoC (System on Chip). Furthermore, we can make a FPGA-based DSP, which DSP functions are implemented with a FPGA. With these merits, the FPGA is also used in the nuclear industry. For example, the safety-critical I and C component is manufactured with the FPGA. The FPGA is programmed with a HDL. The quality of the artifacts programmed with a HDL can impact on the quality of a FPGA. When a hazard fault exists in the artifact of a FPGA and is activated during its operation, an accident caused by the fault in the FPGA occurs. So, it is necessary to ensure the quality of the artifacts. This paper, for the purpose of applying it to the SMART (System-integrated Modular Advanced ReacTor) MMIS project, is to present a preliminary V and V methodology for HDL programmed artifacts. For this, we reviewed the following items: - Characteristics of HDL programming - Applicable requirements for a HDL program used for the safety-critical systems - Fault modes of a FPGA Based on the review, we establish the preliminary V and V methodology

  8. Present status of the standardization of HDL-C, LDL-C, and TG measurement values available in Japan.

    Science.gov (United States)

    Nakajima, Yasuhito; Yamanishi, Hachiro; Matsuura, Nariaki

    2013-05-01

    Control sera used as evaluation samples in external quality control of HDL-C and LDL-C sometimes show disparities in results between direct methods differing in reaction principles. As a result, the present standardization status is unclear. In 2008, we investigated the present status of standardization of HDL-C, LDL-C, and TG measurement values available in Japan. To evaluate accuracy, refrigerated fresh human serum pools used as samples were analyzed irrespective of the manufacturer's method. To evaluate precision, a questionnaire survey regarding the internal quality control status at each institution was carried out. As evaluation criteria, the permissible limits of error of BA and CVA based on JSCC proposals, and the accuracy and imprecision criterion NCEP proposals were used. There were 70 participating institutions for HDL-C, 65 for LDL-C, and 71 for TG. TG values from the institutions showed 83.1-91.5% for both the JSCC BA range and the NCEP criterion range. HDL-C values within the JSCC BA range were 81.4-82.6% and within the NCEP criterion range the value was 98.6%. Similarly, LDL-C values within the JSCC BA range were 89.2% and within the NCEP criterion range the value were 81.5-83.1%, respectively. Concerning precision, a questionnaire regarding internal quality control of each institution was completed. More than 90% of the institutions showed values within the CVA range proposed by the JSCC for all of HDL-C, LDL-C, and TG. Standardization of lipid assays used for metabolic syndrome-based health checkups has been mostly achieved. © 2013 Wiley Periodicals, Inc.

  9. PERFORMANCE EVALUATION OF sUAS EQUIPPED WITH VELODYNE HDL-32E LiDAR SENSOR

    Directory of Open Access Journals (Sweden)

    G. Jozkow

    2017-08-01

    Full Text Available The Velodyne HDL-32E laser scanner is used more frequently as main mapping sensor in small commercial UASs. However, there is still little information about the actual accuracy of point clouds collected with such UASs. This work evaluates empirically the accuracy of the point cloud collected with such UAS. Accuracy assessment was conducted in four aspects: impact of sensors on theoretical point cloud accuracy, trajectory reconstruction quality, and internal and absolute point cloud accuracies. Theoretical point cloud accuracy was evaluated by calculating 3D position error knowing errors of used sensors. The quality of trajectory reconstruction was assessed by comparing position and attitude differences from forward and reverse EKF solution. Internal and absolute accuracies were evaluated by fitting planes to 8 point cloud samples extracted for planar surfaces. In addition, the absolute accuracy was also determined by calculating point 3D distances between LiDAR UAS and reference TLS point clouds. Test data consisted of point clouds collected in two separate flights performed over the same area. Executed experiments showed that in tested UAS, the trajectory reconstruction, especially attitude, has significant impact on point cloud accuracy. Estimated absolute accuracy of point clouds collected during both test flights was better than 10 cm, thus investigated UAS fits mapping-grade category.

  10. Performance Evaluation of sUAS Equipped with Velodyne HDL-32E LiDAR Sensor

    Science.gov (United States)

    Jozkow, G.; Wieczorek, P.; Karpina, M.; Walicka, A.; Borkowski, A.

    2017-08-01

    The Velodyne HDL-32E laser scanner is used more frequently as main mapping sensor in small commercial UASs. However, there is still little information about the actual accuracy of point clouds collected with such UASs. This work evaluates empirically the accuracy of the point cloud collected with such UAS. Accuracy assessment was conducted in four aspects: impact of sensors on theoretical point cloud accuracy, trajectory reconstruction quality, and internal and absolute point cloud accuracies. Theoretical point cloud accuracy was evaluated by calculating 3D position error knowing errors of used sensors. The quality of trajectory reconstruction was assessed by comparing position and attitude differences from forward and reverse EKF solution. Internal and absolute accuracies were evaluated by fitting planes to 8 point cloud samples extracted for planar surfaces. In addition, the absolute accuracy was also determined by calculating point 3D distances between LiDAR UAS and reference TLS point clouds. Test data consisted of point clouds collected in two separate flights performed over the same area. Executed experiments showed that in tested UAS, the trajectory reconstruction, especially attitude, has significant impact on point cloud accuracy. Estimated absolute accuracy of point clouds collected during both test flights was better than 10 cm, thus investigated UAS fits mapping-grade category.

  11. Pre-heparin lipoprotein lipase mass as a potential mediator in the association between adiponectin and HDL-cholesterol in type 2 diabetes.

    Science.gov (United States)

    Maser, Raelene E; Lenhard, M James; Pohlig, Ryan T; Balagopal, P Babu

    2017-03-01

    Lipoprotein lipase (LPL) is a major enzyme in lipid metabolism. Dyslipidemia, characterized by decreased high-density lipoprotein cholesterol (HDL-C), is prevalent in persons with type 2 diabetes mellitus (T2DM). The aim of this study was to determine whether pre-heparin LPL mass mediates the association between adiponectin and HDL-C in individuals with T2DM. Pre-heparin LPL mass was measured via an enzyme-linked immunosorbent assay, adiponectin by radioimmunoassay, and HDL-C was determined enzymatically. Participants' (n = 50) demographics, HbA1c, adiposity, homeostasis model assessment for insulin resistance (HOMA-IR), serum creatinine, and lipids were measured. Path analysis was utilized to test whether pre-heparin LPL mass is a mediator in the relationship between adiponectin and HDL-C. All four criteria for mediation were satisfied in the path analysis. The indirect effect of adiponectin on HDL-C through pre-heparin LPL mass was significant, p = 0.001, whereas the direct effect of adiponectin on HDL-C was not significant, p = 0.074. These results remained consistent even after adjustments for age, gender, body mass index, HOMA-IR, and serum creatinine in the model. The findings in this study suggest that pre-heparin LPL mass may mediate the association between adiponectin and HDL-C in T2DM. This relationship for measures of HDL-C functionality requires future investigation.

  12. Comparison between Gradient Gel Electrophoresis and Nuclear Magnetic Resonance Spectroscopy in Estimating Coronary Heart Disease Risk Associated with LDL and HDL Particle Size

    NARCIS (Netherlands)

    Arsenault, Benoit J.; Lemieux, Isabelle; Després, Jean-Pierre; Wareham, Nicholas J.; Stroes, Erik S. G.; Kastelein, John J. P.; Khaw, Kay-Tee; Boekholdt, S. Matthijs

    2010-01-01

    BACKGROUND: Gradient gel electrophoresis (GGE) and nuclear magnetic resonance (NMR) spectroscopy are both widely accepted methods for measuring LDL and HDL particle size. However, whether or not GGE- or NMR-measured LDL or HDL particle size predicts coronary heart disease (CHD) risk to a similar

  13. HDL cholesterol response to GH replacement is associated with common cholesteryl ester transfer protein gene variation (-629C>A) and modified by glucocorticoid treatment

    NARCIS (Netherlands)

    Dullaart, Robin P. F.; van den Berg, Gerrit; van der Knaap, Aafke M.; Dijck-Brouwer, Janneke; Dallinga-Thie, Geesje M.; Zelissen, Peter M. J.; Sluiter, Wim J.; van Beek, André P.

    2010-01-01

    GH replacement lowers total cholesterol and low-density lipoprotein cholesterol (LDL-C) in GH-deficient adults, but effects on high-density lipoprotein (HDL) cholesterol (HDL-C) are variable. Both GH and glucocorticoids decrease cholesteryl ester transfer protein (CETP) activity, which is important

  14. Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease

    NARCIS (Netherlands)

    Krikken, Jan A.; Gansevoort, Ron T.; Dullaart, Robin P. F.

    Animal experiments show that the kidney contributes to apolipoprotein (apo) A-I catabolism. We tested relationships of HDL cholesterol (HDL-C) and apo-I with kidney function in subjects without severe chronic kidney disease. Included was a random sample of the general population (part of the PREVEND

  15. Will Lipidation of ApoA1 through Interaction with ABCA1 at the Intestinal Level Affect the Protective Functions of HDL?

    Directory of Open Access Journals (Sweden)

    Eric J. Niesor

    2015-01-01

    Full Text Available The relationship between levels of high-density lipoprotein cholesterol (HDL-C and cardiovascular (CV risk is well recognized; however, in recent years, large-scale phase III studies with HDL-C-raising or -mimicking agents have failed to demonstrate a clinical benefit on CV outcomes associated with raising HDL-C, casting doubt on the “HDL hypothesis.” This article reviews potential reasons for the observed negative findings with these pharmaceutical compounds, focusing on the paucity of translational models and relevant biomarkers related to HDL metabolism that may have confounded understanding of in vivo mechanisms. A unique function of HDL is its ability to interact with the ATP-binding cassette transporter (ABC A1 via apolipoprotein (Apo A1. Only recently, studies have shown that this process may be involved in the intestinal uptake of dietary sterols and antioxidants (vitamin E, lutein and zeaxanthin at the basolateral surface of enterocytes. This parameter should be assessed for HDL-raising drugs in addition to the more documented reverse cholesterol transport (RCT from peripheral tissues to the liver. Indeed, a single mechanism involving the same interaction between ApoA1 and ABCA1 may encompass two HDL functions previously considered as separate: antioxidant through the intestinal uptake of antioxidants and RCT through cholesterol efflux from loaded cells such as macrophages.

  16. Desempenho de coelhos em crescimento criados em diferentes densidades populacionais Performance of growing rabbits reared under different stocking densities

    Directory of Open Access Journals (Sweden)

    M.C. Oliveira

    2002-10-01

    Full Text Available O objetivo deste experimento foi avaliar o desempenho de coelhos em crescimento criados em diferentes densidades populacionais. Foram utilizados 136 coelhos, não sexados, desmamados aos 35 dias de idade, em delineamento em blocos ao acaso, com quatro tratamentos e quatro repetições. As densidades avaliadas foram 11,67; 13,34; 15 e 16,67 coelhos/m², correspondentes à ocupação de sete, oito, nove e dez coelhos/gaiola. O período experimental foi de seis semanas. Os coelhos e a ração foram pesados para obtenção do peso final, ganho diário de peso, consumo diário de ração, conversão alimentar e produção de carne total ou kg de carne por m��. Não houve diferença (P>0,05 entre densidade quanto ao peso final, ganho diário de peso, consumo diário de ração e conversão alimentar. A produção em quilos de carne por metro quadrado aumentou (PThe purpose of this experiment was to evaluate the performance of growing rabbits in different stocking densities. One hundred and thirty six non-sexed rabbits, 35 days old, were used in a randomized block design, with four treatments and four repetitions. The evaluated densities were: 11.67; 13.34; 15 e 16.67 rabbits/m² corresponding to the occupation of seven, eight, nine and ten rabbits/cage. At the end of the six-week-experimental-period, rabbits and rations were weighted to obtain final body weight, daily weight gain, daily ration consumption, feed:gain ratio and total meat production or kilograms of meat per square meter. No effects (P>0.05 of stocking densities on final body weight, daily weight gain, daily ration consumption and feed:gain ratio were observed. The production in kilograms of meat per square meter increased linearly (P<0.05 in relation to stocking density (27.86; 31.45; 34.64 and 38.12 kg/m². The increase in stocking density did not affect the performance of the rabbits.

  17. Niche conservatism of Eulophia alta, a trans-Atlantic orchid species

    Directory of Open Access Journals (Sweden)

    Marta Kolanowska

    2014-03-01

    Full Text Available The genus Eulophia embraces over 230 species distributed through the tropical and subtropical Africa, Asia, Australia and the Americas. In Neotropics it is represented by a sole species – E. alta. The aim of the presented study was to evaluate the difference between ecological niches occupied by American and African populations of this species based on the ecological niche modeling. The similarity between the glacial and present niches occupied by E. alta was calculated and the factors limiting the species occurrence were identified. Areas of seasonal tropical forest, tropical savanna and woodland served as refugia for the studied species during last glacial maximum and they were more widespread in Neotropics than in Africa. No significant niche shift after last glacial maximum was observed. The distribution of E. alta in its whole range is restricted mainly by temperature seasonality. The differences in the niches occupied by African and Neotropical populations of E. alta suggest preglacial disjunction of the species range and independent adaptation of both groups. Despite the significant range disjunction of E. alta the species is characterized by relatively high degree of niche conservatism.

  18. Bienestar psicológico en personas con alta capacidad intelectual

    Directory of Open Access Journals (Sweden)

    Pedro Ramiro Olivier

    2016-12-01

    Full Text Available El bienestar psicológico en las personas de alta capacidad intelectual ha sido motivo de controversia en la literatura especializada. En ocasiones se ha considerado que estas personas son más proclives a un desajuste psicológico, mientras que otras veces los resultados han sido poco concluyentes. En el presente trabajo se ha estudiado el bienestar psicológico en personas de altas capacidades intelectuales, administrando la Escala de Bienestar Psicológico a 28 participantes de edades comprendidas entre los 22 y 34 años de edad. Fueron divididos en 2 grupos, uno de altas capacidades y otro de inteligencia estándar. El grupo de altas capacidades había sido identificado como tal 25 años atrás, cuando tenían una edad comprendida entre los 5 y 13 años, utilizando el modelo de los 3 anillos de Renzulli. Los resultados indicaron la inexistencia de diferencias significativas entre los participantes de altas capacidades e inteligencia estándar en las diferentes subescalas de bienestar personal, a excepción de la subescala de bienestar material.

  19. Comparison of the effects of policosanol and atorvastatin on postmenopausal women with type II hypercholesterolemia

    OpenAIRE

    Gladys Castaño; José Illnait; Lilia Fernández; Julio C. Fernández; Rosa Mas; Melbis Mesa; Sarahí Mendoza

    2008-01-01

    Las mujeres postmenopáusicas presentan concentraciones mayores de colesterol total (CT) y del transportado por lipoproteínas de baja densidad (LDL-C) y menores del transportado por lipoproteínas de alta densidad (HDL-C) que las premenopáusicas y controlar su dislipidemia implica reducir las concentraciones de las LDL-C. El policosanol (5 a 20 mg/d) es un hipocolesterolemizante efectivo y la atorvastatina (10 a 80 mg/d) una de las estatinas más efectivas. Este estudio, aleatorizado y a simple-...

  20. Aplicação de redes neurais na formulação de gorduras para bolo baseada em gorduras interesterificadas de soja e algodão

    OpenAIRE

    Scaranto, Bruna Antunes Alves

    2010-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Ciência dos Alimentos, Florianópolis, 2010 Os ácidos graxos trans (AGT) na dieta são oriundos principalmente das gorduras parcialmente hidrogenadas. Estudos comprovam que o consumo de AGT ocasiona obesidade, o aumento da lipoproteína de baixa densidade (LDL) em grau similar ao causado pelos ácidos graxos saturados e a diminuição da lipoproteína de alta densidade (HDL)....

  1. Lipid lowering effect of policosanol and omega-3 fatty acids combined therapy in hypercholesterolemic patients

    OpenAIRE

    José Illnait; Gladys Castaño; Julio Fernández; Ernesto López; Rosa Más; Lilia Fernández; Sarahí Mendoza; Melbis Mesa; Rafael Gámez

    2010-01-01

    Aunque el colesterol de las lipoproteinas de baja densidad (LDL-C) continua siendo el principal objetivo en el manejo de la dislipidemia, la prevencion de la enfermedad coronaria incluye ademas, la modificacion de otros indicadores tales como la disminucion del colesterol no unido a las lipoproteinas de alta densidad y los trigliceridos sericos (TG), asi como el incremento de las HDL-C. Se reconoce que los aceites de pescado ricos en acidos grasos omega 3 (AG-OMEGA3), los cuales reducen los T...

  2. Caracterização de ambientes com alta ocorrência natural de araticum (Annona crassiflora Mart. no Estado de Goiás Environmental characterization with high natural occurrence of araticum (Annona crassiflora Mart. in Goiás State

    Directory of Open Access Journals (Sweden)

    Marcos Antônio Machado Mesquita

    2007-04-01

    Full Text Available Foram selecionadas 14 áreas no Estado de Goiás, Brasil, com alta densidade da espécie araticum (Annona crassiflora Mart. e com menor ação antrópica possível. Cada área possuía 1,0ha, estando subdividida em quatro quadrantes (0,25ha. Foram levantados os dados relativos às características físicas das áreas, das plantas e dos solos (0-20cm. Os resultados demonstraram que o araticum tende a ocorrer em maior densidade em Latossolos não concrecionários dos chapadões, em formação de cerrado típico. A área basal total das plantas entre as áreas em estudo é influenciada positivamente pela concentração de Ca, Mg e K no solo. A densidade de plantas de araticum é influenciada negativamente pela concentração de Fe no solo. A distância geográfica entre as áreas não influenciou na densidade de plantas, na área basal média e na área basal total das plantas de araticum.14 areas were selected in the State of Goiás, Brazil, with high occurrence of the araticum specie (Annona crassiflora Mart. and with smaller human being action possible. Each area had 1ha, and these areas were subdivided in four quadrants of 0,25ha. The relative data of the areas, plants and soils physical characteristics (0-20cm was collected. The results demonstrated that the araticum tends to happen in larger density in "latossolos" in "concrecionários" of the plains in formation of typical cerrado. The total basal area of the araticum plants among the areas in study is influenced positively by the concentration of Ca, Mg and K in the soil. The density of araticum plants is influenced negatively by the concentration of iron in the soil. The geographical distance among the areas did not influence the density of plants, in the medium and total basal area of the araticum plants.

  3. The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism.

    Science.gov (United States)

    Moradi, Masoumeh; Mahmoudi, Maryam; Saedisomeolia, Ahmad; Zahirihashemi, Roxana; Koohdani, Fariba

    2017-05-25

    People may have different responses to the same environmental changes. It has been reported that genome variations may be responsible for these differences. Also, HDL subfractions may be influenced by different genetic variations. The aim of the present study was to determine gene-diet interactions and to evaluate the influence of weight loss on HDL subfractions between two genotypes of -265 T>C APOA-II polymorphism. In the present study, 56 overweight and obese patients with type 2 diabetes mellitus were selected from 697 genotype-specified subjects. After matching for gender, age and BMI at the beginning of the study, an equal number of patients remained on each genotype of APOA-II (TT/TC and CC group). After a 6-week calorie restriction program, 44 patients completed the study. Serum HDL subfractions, including HDL2 and HDL3 and LCAT activity, were compared between the two genotypes and, before and after the intervention, were separated in each genotype. Serum concentration of HDL and its subfractions decreased significantly due to the weight loss. A comparison of the mean changes between the genotypes showed that HDL3 significantly decreased in the CC genotype while, in the TT/TC group, the serum concentration of HDL2 was significantly reduced. However, the increase of LCAT activity was not significant among the two genotypes. A comparison of mean changes of variables within two genotype groups showed that C homozygote carriers lead to a general shift toward larger size HDL subfractions and T allele carriers shift toward smaller size HDL subfractions after weight loss.

  4. Densidade do solo, atributos químicos e sistema radicular do milho afetados pelo pastejo e manejo do solo

    Directory of Open Access Journals (Sweden)

    V. R. Silva

    2000-03-01

    Full Text Available A integração lavoura-pecuária é uma alternativa de renda dos produtores no sul do Brasil. Entretanto, o pisoteio animal e, ou, o preparo de solo podem compactá-lo, prejudicando o crescimento radicular e a produtividade das plantas. Estudaram-se os efeitos do pisoteio animal em regime de pastejo contínuo durante o inverno/primavera e do impacto do plantio direto e do preparo convencional de solo no estado de compactação, atributos químicos e distribuição radicular. Em Podzólico Vermelho-Amarelo de textura superficial franca, foi implantada uma pastagem de estação fria composta por aveia (Avena strigosa Schreb e azevém (Lolium multiflorum L.. A carga animal variou conforme o crescimento da pastagem. Em dezembro de 1996, foi implantada a cultura do milho (Zea mays L. para a produção de silagem, usando os seguintes tratamentos: plantio direto na área não pastejada, plantio direto após o pastejo, preparo convencional de solo na área não pastejada e preparo convencional de solo após pastejo. As avaliações apresentadas neste estudo são referentes ao terceiro ano de cultivo, no qual houve um período de pastejo de 107 dias. Aos 45 dias da emergência do milho, foram abertas trincheiras (100 x 40 cm para visualizar a distribuição do sistema radicular e coletar amostras de solo, a cada 5 cm, para caracterização química e determinação da densidade do solo e de raízes. Ao longo do perfil (0-40 cm, o desenho da distribuição de raízes indicou maior quantidade de raízes no preparo convencional de solo, concordando com os resultados de densidade de raízes. O pisoteio animal não teve efeito sobre as características físicas, possivelmente pelo fato de o resíduo da pastagem permanecer próximo a 1,0 Mg ha-1 de matéria seca. A densidade do solo no plantio direto, na camada de 5-10 cm, foi de 1,41 Mg m-3, tanto na área pastejada como na não pastejada. No preparo convencional de solo, esses valores foram de 1,15 Mg m-3

  5. Reflexões acerca das nanotecnologias e as novas densidades técnicas-científicas-informacionais na agricultura

    Directory of Open Access Journals (Sweden)

    Soraia de Fátima Ramos

    2009-01-01

    Full Text Available As pesquisas sobre os potenciais usos das nanotecnologias no agronegócio suscitam enormes dúvidas sobre os reais benefícios ou malefícios em relação à adoção desta inovação. Daí a preocupação desta investigação em incluir as ciências humanas nos debates sobre a difusão das nanotecnologias. Pressupõe-se que, dada a efetiva incorporação dos novos produtos e processos nanotecnológicos, irá se configurar um aprofundamento das densidades técnicas-científicas- informacionais no espaço agrário brasileiro.

  6. Nuevo equipo para medir la distribución de la densidad aparente de piezas cerámicas: DENSEXPLORER

    Directory of Open Access Journals (Sweden)

    Mallol, G.

    2014-04-01

    Full Text Available Densexplorer is the first device for industrial manufacturing plant capable of determining the distribution of bulk density of large ceramic tiles in a non-destructively way, which is not harmful to health, respectful with the environment and that increases the productivity of the process regarding to existing equipment. The system is based on the X-ray absorption technique, in which a material absorbs an amount of radiation depending on its thickness and density.Densexplorer es el primer dispositivo capaz de determinar la distribución de la densidad aparente de baldosas cerámicas industriales de gran tamaño, de forma no destructiva, no perjudicial para la salud, respetuosa con el medio ambiente, incrementando la productividad respecto a los equipos actuales. El sistema está basado en la medida puntual de la absorción de rayos X y del espesor de la pieza.

  7. Densidade populacional do feijÃo-caupi sob nÃveis de irrigaÃÃo

    OpenAIRE

    Simone Raquel Mendes de Oliveira

    2013-01-01

    O feijÃo-caupi à uma cultura tradicionalmente produzida nas regiÃes Norte e Nordeste. No estado do PiauÃ, seu baixo rendimento mÃdio ainda persiste nos dias atuais, apesar da cultura ser bem adaptada Ãs condiÃÃes edafoclimÃticas da regiÃo e de existirem cultivares melhoradas disponÃveis no mercado. Assim, estudos que descrevam melhores prÃticas de manejo da cultura com a combinaÃÃo adequada da densidade de plantas e lÃmina de irrigaÃÃo, sÃo importantes à medida que sÃo capazes de apresentar a...

  8. Un modelo educativo de adaptación curricular en alumnos de altas capacidades

    Directory of Open Access Journals (Sweden)

    Celestino RODRÍGUEZ

    2010-01-01

    Full Text Available En base a la legislación educativa española vigente, las altas capacidades se incluyen en el marco de las necesidades educativas específicas de apoyo educativo. En el presente estudio ejemplificamos una propuesta de adaptación curricular individual para alumnos con altas capacidades, que pretende promover el desarrollo equilibrado de los objetivos de aprendizaje propuestos en su programación de aula. Todo ello, a través de una descripción por pasos del proceso, partiendo de una evaluación previa de las altas capacidades, una planificación de la intervención educativa, una propuesta educativa concreta (ejemplificada en el área de Lengua castellana y el desarrollo de programas complementarios.

  9. Rentabilidade da cultura da macieira cultivar Gala em duas densidades de plantio Investment return for Gala apple cultivar using two planting densities

    Directory of Open Access Journals (Sweden)

    Carlos Leomar Kreuz

    2002-03-01

    Full Text Available O presente trabalho discute, com base em um estudo de caso, a viabilidade econômica de ampliar a densidade de plantio de macieiras cultivar Gala de 1.000 plantas por hectare para 3.378 plantas por hectare. Os resultados mostraram que a taxa interna de retorno não variou (próxima de 1,61% ao mês, independentemente da densidade utilizada, o que sugere o uso da menor densidade de plantio, uma vez que esta requer um menor volume de recursos financeiros. O custo unitário de produção também se mantém praticamente o mesmo ao se variar a densidade de plantio.The present study was carried out to analyse economic performances of Gala apple orchards at different planting densities. Two orchard densities (1,000 and 3,378 plants/ha were evaluated in an orchard near Fraiburgo, SC, Brazil. The use of both planting densities resulted in the same internal rate of return (approximately 1.6% a month. It is suggested to use a lower planting system, once it requires less capital. Unit cost also remained the same for both planting densities used in this study.

  10. ENFERMEDADES Y COMPONENTES DE RENDIMIENTO EN LÍNEAS DE FRÉJOL BAJO TRES DENSIDADES DE SIEMBRA

    Directory of Open Access Journals (Sweden)

    Felipe Rafael Garc\\u00E9s-Fiallos

    2014-01-01

    Full Text Available El objetivo fue evaluar las enfermedades, el rendimiento y sus componen - tes en líneas de fréjol bajo tres distanciamientos de siembra. El trabajo se realizó durante la época seca del año 2011, en la Universidad Técnica Estatal de Quevedo (UTEQ, Quevedo, Ecuador. Se determinó la incidencia y severidad de la roya ( Uromyces appendiculatus y mustia hilachosa ( Rizoctonia solani en los estadíos R7 (formación en legumbres y R8 (llenado de legumbres, y después de la cosecha la incidencia de las pudriciones radiculares ( Macrophomina phaseolina y R. solani . Los componentes de rendimiento (número de nudos, legumbres, granos, granos por legumbre, legumbres estériles y granos por planta y peso de granos. Se empleó un Diseño de Bloques Completos al Azar (DBCA con doce tratamientos y tres repeticiones, con arreglo factorial de 4 (líneas promisorias x 3 (planta/m. Para la comparación entre las medias de los tratamientos se empleó la prueba de Tukey al 5% de probabilidad del error. Las líneas promisorias de fréjol EVG 06-103 y SER-03 presentaron menor intensidad de enfermedades. Un aumento en la densidad poblacional causó un acrecentamiento en la intensidad de la roya. Las líneas SER-08 y SER-03 obtuvieron la mayor productividad según la mayoría de componentes de rendimiento y peso de granos. Finalmente, el incremento de la densidad de plantas promovió reducción significativa en el número de legumbres, granos y granos por legumbre por planta, contrario al aumento observado en el peso de granos

  11. Sistemas de labranza y densidades de la batata: calidad del suelo y de las raíces tuberosas.

    Directory of Open Access Journals (Sweden)

    Maiby Pérez-Darniz

    2016-12-01

    Full Text Available El objetivo de este trabajo fue determinar el efecto de sistemas de labranza y densidades de siembra en la calidad de las raíces tuberosas de batata (Ipomoea batata (L Lamb.. El estudio se realizó en la Universidad Central de Venezuela, en el año 2014. Se determinaron los grados de severidad de la degradación del suelo y su correspondencia con las escalas de preferencia basadas en el peso unitario y dimensiones de la raíz tuberosa. Se usó un arreglo en franjas, donde los sistemas de labranza (SL fueron asignados a las parcelas, y las densidades de siembra (Ds a las franjas. Los SL consistieron en labranza vertical con cincel (LC, con arado de disco (LA, convencional con tres pases de rastra de disco (LCo y mínima con un pase de rastra de disco (LM. Las Ds fueron de 0,25 cm (D1 y 0,15 cm (D2 en la hilera. La calidad física del suelo fue superior en los tratamientos de LA. De estos, la combinación con la distancia de siembra más larga (LA-D1 favoreció la mayor calidad postcosecha del cultivo. Al contrario, en los tratamientos con cincel se promovió la menor aceptación del consumidor. La ligera a moderada severidad de la degradación del suelo no explicó la variación de la calidad postcosecha. Se in ere sobre la menor tasa de movimiento de agua en LC, que promovió un exceso de humedad y la más baja calidad de la raíz tuberosa.

  12. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL))

    Czech Academy of Sciences Publication Activity Database

    Dobiášová, Milada; Frohlich, J.

    2001-01-01

    Roč. 34, č. 7 (2001), s. 583-588 ISSN 0009-9120. [Congress of the European Atherosclerosis Society /71./. Athens, 26.05.1999-29.05.1999] R&D Projects: GA ČR GV306/96/K220; GA MZd NE5465 Institutional research plan: CEZ:AV0Z5011922 Keywords : atherogenic index of plasma * HDL-cholesterol * triglycerides Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 1.516, year: 2001

  13. Variabilidade Espacial e Densidade Amostral da Suscetibilidade Magnética e dos Atributos de Argissolos da Região de Manicoré, AM

    Directory of Open Access Journals (Sweden)

    Ivanildo Amorim de Oliveira

    2015-06-01

    Full Text Available A dificuldade em encontrar informações recentes sobre o comportamento espacial dos atributos dos solos na Região Amazônica tem sido preocupação de muitos pesquisadores. Em razão da grande dificuldade e dos custos para avaliar os atributos dos solos, têm-se utilizados métodos alternativos para predição de atributos do solo como a suscetibilidade magnética. Sendo assim, o objetivo deste trabalho foi avaliar a variabilidade espacial da suscetibilidade magnética (SM, os atributos físicos e químicos e determinar a densidade amostral de coleta em Argissolo Vermelho sob floresta nativa, Terra Preta Arqueológica (TPA sob cultivo, e pastagem na região de Manicoré, Amazonas. Nessas áreas, foram estabelecidas malhas com dimensão de 70 × 70 m e demarcados pontos nessas malhas, espaçados a cada 10 m, totalizando 64 pontos. Esses pontos foram georreferenciados e, em seguida, realizaram-se as coletas de solo em cada ponto da malha nas camadas de 0,00-0,20 e 0,40-0,60 m para determinar atributos químicos (pH em água, matéria orgânica, P, K, Ca, Mg e acidez potencial, físicos (textura, macroporosidade, microporosidade, diâmetro médio ponderado, densidade do solo e densidade de partículas e suscetibilidade magnética. Os dados foram submetidos à análise de variância, e as médias, comparadas pelo teste de Tukey a 5 %. Realizou-se a estatística descritiva. Para caracterizar a variabilidade, fez-se a geoestatística com uso de semivariograma escalonado. O alcance dos semivariogramas escalonados foi utilizado para determinar a densidade amostral mínima de coleta para estimar a variabilidade dos atributos estudados. As áreas de TPA e pastagem apresentaram maior variabilidade, apresentando menor alcance e maior densidade amostral (cinco pontos por hectare. A SM apresentou comportamento espacial similar aos atributos físicos e químicos estudados, sendo a densidade amostral da SM próxima à densidade amostral dos atributos nos

  14. Influencias de la densidad y podas sobre la producción de Pinus taeda L. a los 7 años de edad.

    Directory of Open Access Journals (Sweden)

    Rubén Costas

    2010-08-01

    Full Text Available En un ensayo con 3 niveles de densidad y 12 tratamientos de poda, se evaluaron los efectos de la densidad, la altura de poda, el número de levantes de poda y la interacción entre la densidad y las podas sobre la producción de la masa de Pinus taeda L. a los 7 años de edad. Las variables evaluadas fueron el diámetro a la altura de pecho medio (DAP, la altura media, el volumen individual, el volumen por unidad de superficie, el área basal, el diámetro máximo sobre muñón (DMSM, el coeficiente de forma de Girard (CFG, el diámetro de ramas (DRBC y el ángulo de inserción de las ramas (ARBC en la base de la copa. En los tratamientos con mayor densidad de plantación se observaron mayores volúmenes por unidad de superficie, área basal y CFG que en los tratamientos con menor densidad. Estos produjeron mayores DAP, volúmenes individuales, DMSM, DRBC y ARBC que los tratamientos con mayores densidades. Los tratamientos con menores alturas finales de poda produjeron mayores DAP, volúmenes individuales, área basal y volúmenes por unidad de superficie que los tratamientos con mayores alturas de poda. Los menores DMSM se obtuvieron con alturas finales de poda de 3,30 m y 4,40 m realizadas a los 4 años de edad y los mayores DMSM ocurrieron al no efectuarse podas a los 5 años hasta 5,50 m y 6,60 m. No se encontraron diferencias significativas entre los valores medios de DRBC, ARBC y CFG producidos por los 12 tratamientos de poda. La interacción entre densidad y los tratamientos de poda no fue significativa para ninguna de las variables respuestas.

  15. INFLUENCIAS DE LA DENSIDAD Y PODAS SOBRE LA PRODUCCIÓN DE Pinus taeda L. A LOS 7 AÑOS DE EDAD.

    Directory of Open Access Journals (Sweden)

    Pedro Irschick

    2005-08-01

    Full Text Available En un ensayo con 3 niveles de densidad y 12 tratamientos de poda, se evaluaron los efectos de la densidad, la altura de poda, el número de levantes de poda y la interacción entre la densidad y las podas sobre la producción de la masa de Pinus taeda L. a los 7 años de edad. Las variables evaluadas fueron el diámetro a la altura de pecho medio (DAP, la altura media, el volumen individual, el volumen por unidad de superficie, el área basal, el diámetro máximo sobre muñón (DMSM, el coeficiente de forma de Girard (CFG, el diámetro de ramas (DRBC y el ángulo de inserción de las ramas (ARBC en la base de la copa. En los tratamientos con mayor densidad de plantación se observaron mayores volúmenes por unidad de superficie, área basal y CFG que en los tratamientos con menor densidad. Estos produjeron mayores DAP, volúmenes individuales, DMSM, DRBC y ARBC que los tratamientos con mayores densidades. Los tratamientos con menores alturas finales de poda produjeron mayores DAP, volúmenes individuales, área basal y volúmenes por unidad de superficie que los tratamientos con mayores alturas de poda. Los menores DMSM se obtuvieron con alturas finales de poda de 3,30 m y 4,40 m realizadas a los 4 años de edad y los mayores DMSM ocurrieron al no efectuarse podas a los 5 años hasta 5,50 m y 6,60 m. No se encontraron diferencias significativas entre los valores medios de DRBC, ARBC y CFG producidos por los 12 tratamientos de poda. La interacción entre densidad y los tratamientos de poda no fue significativa para ninguna de las variables respuestas.

  16. Bienestar psicológico en personas con alta capacidad intelectual

    OpenAIRE

    Ramiro Olivier, Pedro; Navarro Guzmán, José I.; Menacho Jiménez, Inmaculada; López Sinoga, M. Mar; García Sedeño, Manuel A.

    2016-01-01

    El bienestar psicológico en las personas de alta capacidad intelectual ha sido motivo de controversia en la literatura especializada. En ocasiones se ha considerado que estas personas son más proclives a un desajuste psicológico, mientras que otras veces los resultados han sido poco concluyentes. En el presente trabajo se ha estudiado el bienestar psicológico en personas de altas capacidades intelectuales, administrando la Escala de Bienestar Psicológico a 28 participantes de edades comprendi...

  17. Uma interface PCI para periféricos de alta velocidade

    OpenAIRE

    de Lima Pereira, Adilson

    2003-01-01

    Peripheral Component Interconnect (PCI) é um protocolo de comunicação para dispositivos de alta velocidade que requerem uma alta vazão de dados (throughput), tais como, controladores de vídeo e de rede de computadores. O protocolo PCI é um protocolo síncrono e possui várias versões com diferentes larguras de barramento e freqüência. Esta dissertação, em particular, trata da implementação do protocolo PCI para dispositivos do tipo escravos targets, versão 2.2, com 32 bits de dad...

  18. Papel de la enfermería en las hemorragias digestivas altas en urgencias y emergencias

    OpenAIRE

    Ibáñez García, Patricia

    2015-01-01

    La hemorragia digestiva alta es la complicación gastroenterológica más importante. Está delimitada por el esfínter esofágico superior y el ángulo de Treitz, es decir, es aquella que se produce en esófago, estómago o duodeno. El objetivo de esta revisión bibliográfica es conocer cuál es el papel que ejerce la enfermería ante una hemorragia digestiva alta en las emergencias extrahospitalarias y urgencias hospitalarias. Se diferencian dos tipos de hemorragias según la causa que las produzc...

  19. 50 años de alta velocidad en Japón

    OpenAIRE

    Pigem Cameselle, Ramiro

    2008-01-01

    Al inaugurar los 515 kilómetros de línea de alta velocidad entre Tokio y Osaka en octubre de 1964, Japón alcanzó un logro todavía mayor que el de impulsar su propia economía. Abrió una era del transporte completamente nueva con un innovador sistema ferroviario. Con ello prestó un innegable servicio al mundo ferroviario, desencadenando un auge global de la alta velocidad e inyectando aire fresco a una industriar que estaba en claro declive. Casi 50 años más tarde, los 210 km/h inic...

  20. Pilot-Scale Demonstration of ALTA for NOx Control in Pulverized Coal-Fired Boilers

    Energy Technology Data Exchange (ETDEWEB)

    Andrew Fry; Devin Davis; Marc Cremer; Bradley Adams

    2008-04-30

    This report describes computational fluid dynamics (CFD) modeling and pilot-scale testing conducted to demonstrate the ability of the Advanced Layered Technology Approach (ALTA) to reduce NO{sub x} emissions in a pulverized coal (PC) boiler. Testing specifically focused on characterizing NO{sub x} behavior with deep burner staging combined with Rich Reagent Injection (RRI). Tests were performed in a 4 MBtu/hr pilot-scale furnace at the University of Utah. Reaction Engineering International (REI) led the project team which included the University of Utah and Combustion Components Associates (CCA). Deep burner staging and RRI, combined with selective non-catalytic reduction (SNCR), make up the Advanced Layered Technology Approach (ALTA) for NO{sub x} reduction. The application of ALTA in a PC environment requires homogenization and rapid reaction of post-burner combustion gases and has not been successfully demonstrated in the past. Operation of the existing low-NO{sub x} burner and design and operation of an application specific ALTA burner was guided by CFD modeling conducted by REI. Parametric pilot-scale testing proved the chemistry of RRI in a PC environment with a NOx reduction of 79% at long residence times and high baseline NOx rate. At representative particle residence times, typical operation of the dual-register low-NO{sub x} burner provided an environment that was unsuitable for NO{sub x} reduction by RRI, showing no NOx reduction. With RRI, the ALTA burner was able to produce NO{sub x} emissions 20% lower than the low-NO{sub x} burner, 76 ppmv vs. 94 ppmv, at a burner stoichiometric ratio (BSR) of 0.7 and a normalized stoichiometric ratio (NSR) of 2.0. CFD modeling was used to investigate the application of RRI for NO{sub x} control on a 180 MW{sub e} wall-fired, PC boiler. A NO{sub x} reduction of 37% from baseline (normal operation) was predicted using ALTA burners with RRI to produce a NO{sub x} emission rate of 0.185 lb/MBtu at the horizontal nose of

  1. Pemberian Teh Kombucha Pada Air Minum Terhadap Nilai Ldl Kolesterol Dan Hdl Kolesterol Darah Ayam Broiler (Gallus SP)

    OpenAIRE

    Djaelani, Muhammad Anwar; Tana, Silvana

    2015-01-01

    The risk of consuming large quantities of food containing cholesterol has been widely known. By knowing the cholesterol content of food products, people could restrict their consumption of high cholesterol food. This study was to knew LDL cholesterol and HDL cholesterol of blood broiler chickens after treated with kombucha tea. This research used the CP 707 broiler strains chickens aged 1 week, treated with kombucha tea that has been fermented for 12 days at a temperature of 25oC. 20 broiler ...

  2. Triglyceride/HDL ratio as a screening tool for predicting success at reducing anti-diabetic medications following weight loss.

    Science.gov (United States)

    Palamaner Subash Shantha, Ghanshyam; Kumar, Anita Ashok; Kahan, Scott; Irukulla, Pavan Kumar; Cheskin, Lawrence Jay

    2013-01-01

    Intentional weight loss, by reducing insulin resistance, results in both better glycemic control and decreased need for anti-diabetic medications. However, not everyone who is successful with weight loss is able to reduce anti-diabetic medication use. In this retrospective cohort study, we assessed the predictive accuracy of baseline triglyceride (TGL)/HDL ratio, a marker of insulin resistance, to screen patients for success in reducing anti-diabetic medication use with weight loss. Case records of 121 overweight and obese attendees at two outpatient weight management centers were analyzed. The weight loss intervention consisted of a calorie-restricted diet (~1000Kcal/day deficit), a behavior modification plan, and a plan for increasing physical activity. Mean period of follow-up was 12.5 ± 3.5 months. By study exit, mean weight loss and mean HbA1c% reduction were 15.4 ± 5.5 kgs and 0.5 ± 0.2% respectively. 81 (67%) in the study cohort achieved at least 1 dose reduction of any anti-diabetic medication. Tests for predictive accuracy of baseline TGL/HDL ratio ≤ 3 to determine success with dose reductions of anti-diabetic medications showed a sensitivity, specificity, positive predictive value, negative predictive value, area under the curve, likelihood ratio (LR) + and LR-of 81, 83, 90, 70, 78, 4.8 and 0.2, respectively. Reproducibility of TGL/HDL ratio was acceptable. TGL/HDL ratio shows promise as an effective screening tool to determine success with dose reductions of anti-diabetic medications. The results of our study may inform the conduct of a systematic review using data from prior weight loss trials.

  3. Variação, divergência e correlações genéticas entre caracteres silviculturais e densidade básica da madeira em progênies de Myracrodruon urundeuva (Engler Fr. Allem. Genetic variation, divergence and correlations among silvicultural traits and wood density in progenies of Myracrodruon urundeuva (Engler Fr. Allem.

    Directory of Open Access Journals (Sweden)

    Eduardo Luiz LONGUI

    2011-06-01

    Full Text Available Myracrodruon urundeuva foi muito explorada no passado devido às qualidades de sua madeira e tornou-se escassa em todas as áreas naturais de ocorrência, sendo atualmente considerada como ameaçada de extinção (categoria vulnerável. Isso torna a espécie importante para estudos relacionados à estrutura genética de populações para fins de conservação e melhoramento genético. Assim, a partir de um teste de progênies, instalado em 1987, em Selvíria–MS, foram estimados parâmetros genéticos para a densidade básica da madeira em três posições radiais (medula, intermediária e casca, a distância genética de Mahalanobis e correlações genéticas e fenotípicas entre caracteres de crescimento (altura total, altura do fuste e diâmetro à altura do peito – DAP e densidade básica da madeira. A população apresentou alta densidade básica da madeira (0,75 g.cm-3 e alta herdabilidade (0,64 para este carácter na posição intermediária e na medula, indicando forte controle genético e a possibilidade de melhoramento por seleção. Os resultados também mostraram que para essa população de M. urundeuva deve-se utilizar as progênies 1 e 14 para obtenção de híbridos mais heteróticos por apresentarem maior distância de Mahalanobis; as progênies 14 e 20 por outro lado possuem distâncias muito próxima constituindo pares de progênies semelhantes, o que é interessante para se buscar melhoramento por retrocruzamento. Tais informações são importantes para escolha de métodos adequados de conservação e melhoramento genético.In the past, Myracrodruon urundeuva was intensively exploited due the quality of its wood and became scarce in all natural areas of occurrence, being actually considered in extinction (vulnerable category. This makes the species important for studies of population genetic structure for conservation and breeding purposes. Thus, from a progeny test established in 1987 in Selvíria, Mato Grosso do Sul

  4. Diseño de decodificadores de altas prestaciones para código LDPC

    OpenAIRE

    Angarita Preciado, Fabian Enrique

    2013-01-01

    En esta tesis se han investigado los algoritmos de decodificación para códigos de comprobación de paridad de baja densidad (LDPC) y las arquitecturas para la implementación hardware de éstos. El trabajo realizado se centra en los algoritmos del tipo de intercambio de mensajes para códigos estructurados los cuales se incluyen en varios estándares de comunicaciones. Inicialmente se han evaluado las prestaciones de los algoritmos existentes Sum-product, Min-Sum y las principales variantes de...

  5. Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol? : a retrospective study.

    Science.gov (United States)

    Wongcharoen, Wanwarang; Sutthiwutthichai, Satjatham; Gunaparn, Siriluck; Phrommintikul, Arintaya

    2017-01-05

    It has recently been shown that non-high density lipoprotein cholesterol (non-HDL-C) may be a better predictor of cardiovascular risk than low density lipoprotein cholesterol (LDL-C). Based on known ethic differences in lipid parameters and cardiovascular risk prediction, we sought to study the predictability of attaining non-HDL-C target and long-term major adverse cardiovascular event (MACE) in Thai patients after acute myocardial infarction (AMI) compared to attaining LDL-C target. We retrospectively obtained the data of all patients who were admitted at Maharaj Nakorn Chiang Mai hospital due to AMI during 2006-2013. The mean non-HDL-C and LDL-C during long-term follow-up were used to predict MACE at each time point. The patients were classified as target attainment if non-HDL-C LDL-C LDL-C target and 21.2% experienced MACEs. LDL-C and non-HDL-C were directly compared in Cox regression model. Compared with non-HDL-C 130 mg/dl had higher incidence of MACEs (HR 3.15, 95% CI 1.46-6.80, P = 0.003). Surprisingly, LDL-C >100 mg/dl was associated with reduced risk of MACE as compared to LDL LDL-C goal was not associated with the higher risk. Therefore, non-HDL-C may be a more suitable target of dyslipidemia treatment than LDL-C in patients after AMI.

  6. DOSES DE NITROGÊNIO E DENSIDADES DE PLANTAS COM E SEM UM REGULADOR DE CRESCIMENTO AFETANDO O TRIGO, CULTIVAR OR-1 NITROGEN DOSES AND PLANT DENSITIES WITH AND WITHOUT A GROWTH REGULATOR AFFECTING WHEAT, CULTIVAR OR-1

    Directory of Open Access Journals (Sweden)

    Jeferson Zagonel

    2002-02-01

    Full Text Available Doses de nitrogênio e elevadas populações de plantas são utilizadas visando a obtenção de altas produtividades em trigo. Porém, estes fatores podem promover o acamamento das plantas, especialmente para as cultivares de porte médio ou alto. O uso de produtos que reduzem a estatura das plantas pode minimizar este problema. Visando avaliar o efeito do regulador de crescimento trinexapc-ethyl em diferentes populações de plantas e doses de nitrogênio, na cultivar de trigo OR-1, instalou-se um experimento na Fazenda Escola "Capão da Onça", da Universidade Estadual de Ponta Grossa, em Ponta Grossa, PR, no ano de 1999. O delineamento experimental foi blocos ao acaso em esquema fatorial 2 x 3 x 4, em quatro repetições. Os vinte e quatro tratamentos constaram da aplicação de 125 g i.a./ha de trinexapac-ethyl e testemunha; densidades de 55, 75 e 112 plantas/m no espaçamento de 0,17m entre fileiras e doses de 0, 45, 90 e 135kg/ha de nitrogênio em cobertura. A aplicação do trinexapac-ethyl resultou em plantas com entre-nós mais curtos; em aumento do número de espigas/m e da produtividade. Com o aumento da dose de nitrogênio, ocorreu aumento da estatura das plantas, do número de espigas/m e da produtividade. Com o aumento da densidade de plantas, o diâmetro do caule, a massa seca das plantas e o número de grãos por espiga diminuíram mas o número de espigas/m e o peso de mil grãos aumentaram, sem afetarem a produtividade. Não ocorreu acamamento em nenhum dos tratamentos.Elevated nitrogen rates and high plant populations are adopted with the purpose of achieving high wheat yields. However, these factors may promote the lodging of the plants, especially for the medium and tall height cultivars. The utilization of products which reduce plant height could minimize this problem. With the aim of evaluating the effects of a growth regulator on different plant populations and nitrogen rates for the wheat cultivar OR-1, an experiment was

  7. Evaluation of alcohol outlet density and its relation with violence Avaliação da densidade de pontos de vendas de álcool e sua relação com a violência

    Directory of Open Access Journals (Sweden)

    Ronaldo Laranjeira

    2002-08-01

    , buscou-se investigar a disponibilidade de bebidas alcoólicas em uma região densamente povoada e melhorar o entendimento sobre o acesso a essa substância, para que ações preventivas futuras possam beneficiar-se dessas informações. MÉTODOS: O estudo foi realizado em uma região do Município de São Paulo, SP, Brazil. Foram treinados 24 entrevistadores, moradores da região, para fazerem a coleta de dados. Foi selecionada uma área de 19 ruas, cobrindo uma distância de 3.7 km. Foi feito um perfil de cada ponto de venda de bebidas alcoólicas dessa região. RESULTADOS: Foram registrados 107 pontos de venda de álcool. O número de outras propriedades nessa região foi de 1.202. Duas medidas de densidade de pontos de venda podem ser calculadas: número de pontos de venda por kilômetro de rua (29 pontos/km e proporção de todas as propriedades de venda de álcool (1 em 12. CONCLUSÕES: Comparado a estudos internacionais principalmente de países desenvolvidos, a área estudada tem a mais alta densidade de pontos de vendas de álcool registrada na literatura médica. As informações sobre as vendas de álcool e os locais de venda contribuíram para melhorar o entendimento do acesso ao álcool na região estudada. Ações preventivas futuras poderão beneficiar-se dessas informações.

  8. Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin

    Science.gov (United States)

    Kühnast, Susan; van der Tuin, Sam J.L.; van der Hoorn, José W.A.; van Klinken, Jan B.; Simic, Branko; Pieterman, Elsbet; Havekes, Louis M.; Landmesser, Ulf; Lüscher, Thomas F.; Willems van Dijk, Ko; Rensen, Patrick C.N.; Jukema, J. Wouter; Princen, Hans M.G.

    2015-01-01

    Background The residual risk that remains after statin treatment supports the addition of other LDL-C-lowering agents and has stimulated the search for secondary treatment targets. Epidemiological studies propose HDL-C as a possible candidate. Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from atheroprotective HDL to atherogenic (V)LDL. The CETP inhibitor anacetrapib decreases (V)LDL-C by ∼15–40% and increases HDL-C by ∼40–140% in clinical trials. We evaluated the effects of a broad dose range of anacetrapib on atherosclerosis and HDL function, and examined possible additive/synergistic effects of anacetrapib on top of atorvastatin in APOE*3Leiden.CETP mice. Methods and results Mice were fed a diet without or with ascending dosages of anacetrapib (0.03; 0.3; 3; 30 mg/kg/day), atorvastatin (2.4 mg/kg/day) alone or in combination with anacetrapib (0.3 mg/kg/day) for 21 weeks. Anacetrapib dose-dependently reduced CETP activity (−59 to −100%, P < 0.001), thereby decreasing non-HDL-C (−24 to −45%, P < 0.001) and increasing HDL-C (+30 to +86%, P < 0.001). Anacetrapib dose-dependently reduced the atherosclerotic lesion area (−41 to −92%, P < 0.01) and severity, increased plaque stability index and added to the effects of atorvastatin by further decreasing lesion size (−95%, P < 0.001) and severity. Analysis of covariance showed that both anacetrapib (P < 0.05) and non-HDL-C (P < 0.001), but not HDL-C (P = 0.76), independently determined lesion size. Conclusion Anacetrapib dose-dependently reduces atherosclerosis, and adds to the anti-atherogenic effects of atorvastatin, which is mainly ascribed to a reduction in non-HDL-C. In addition, anacetrapib improves lesion stability. PMID:25142968

  9. Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China.

    Science.gov (United States)

    Chen, Qing-Jie; Lai, Hong-Mei; Chen, Bang-Dang; Li, Xiao-Mei; Zhai, Hui; He, Chun-Hui; Pan, Shuo; Luo, Jun-Yi; Gao, Jing; Liu, Fen; Ma, Yi-Tong; Yang, Yi-Ning

    2016-02-19

    Elevated LDL-C/HDL-C ratio has been shown to be a marker of lipid metabolism as well as a good predictor of coronary artery disease (CAD). Thus, the aim of this study was to investigate whether the LDL-C/HDL-C ratio is useful for detecting cardiovascular disease (CVD) risk factors in general healthy Uygur adults in Xinjiang. A total of 4047 Uygur subjects aged ≥35 years were selected from the Cardiovascular Risk Survey (CRS) study which was carried out from October 2007 to March 2010. Anthropometric data, blood pressure, lipid profile and fasting glucose were measured in all participants. The prevalence, sensitivity, specificity and distance on the receiver operating characteristic (ROC) curve of each LDL-C/HDL-C ratio were calculated. The prevalence of high LDL-C and low HDL-C cholesterol was high and positively correlated with higher LDL-C/HDL-C ratio in the Uygur population. In both men and women, we detected a slight apparent trend of high prevalence of hypertension and hypercholesterolemia with higher LDL-C/HDL-C ratio. Our study also demonstrated that the discriminatory power of the LDL-C/HDL-C ratio for CVD risk factors was slightly stronger in men than in women. Analysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or ≥two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women. The results of this study showed that a LDL-C/HDL-C ratio cut-off of 2.5 might be used as the predictive marker to detect CVD risk factors among Uygur adults in Xinjiang.

  10. Respostas lactacidêmicas de ratos ao treinamento intermitente de alta intensidade

    Directory of Open Access Journals (Sweden)

    Ana Carolina Panveloski-Costa

    2012-04-01

    Full Text Available Durante contrações musculares de alta intensidade intervaladas por curtos períodos de tempo há importante participação do metabolismo glicolítico e, consequentemente, aumento das concentrações de lactato sanguíneo. O objetivo do estudo foi avaliar as respostas lactacidêmicas agudas e crônicas de ratos Wistar submetidos a um treinamento intermitente de alta intensidade (salto tipo jump squat de três sessões semanais, a cada 24h, três séries de 12 repetições com intervalos de 60s entre cada uma. Houve aumento das concentrações de lactato sanguíneo durante a sessão aguda do treinamento (lactacidemia basal vs. lactacidemia após último esforço, P < 0,001. Contrariamente, após seis semanas de treinamento, ocorreu redução de 49% na resposta lactacidêmica ao exercício em relação à primeira sessão, P = 0,0002. O exercício intermitente de alta intensidade intervalado favorece a participação do sistema glicolítico; no entanto, o treinamento intermitente de alta intensidade promove redução das respostas lactacidêmicas, sugerindo melhora da capacidade de ressíntese de fosfocreatina e da biogênese mitocondrial.

  11. 215. Evaluación de la terapia local con atorvastatina a altas concentraciones

    Directory of Open Access Journals (Sweden)

    J.M. Garrido Jiménez

    2010-01-01

    Conclusiones: el tratamiento con atorvastatina a altas concentraciones ejerce diferentes efectos sobre la viabilidad, proliferación y funcionalidad celular dependiendo del estado basal de las células endoteliales, siendo las células previamente activadas las que presentan niveles óptimos de viabilidad y funcionalidad.

  12. Grounding the past : the praxis of participatory archaeology in the Mixteca Alta, Oaxaca, Mexico

    NARCIS (Netherlands)

    Geurds, Alexander

    2007-01-01

    "Grounding the Past" addresses archaeological field praxis and its role in the political present of Santiago Tilantongo and Santiago Apoala, two communities in the Mixteca Alta region of Oaxaca, Mexico. Efforts to involve local stakeholder communities in archaeology have become an important issue

  13. 77 FR 38823 - Notice of Availability of the Alta East Wind Project Draft Environmental Impact Statement...

    Science.gov (United States)

    2012-06-29

    ... DEPARTMENT OF THE INTERIOR Bureau of Land Management [CACA-052537, LLCAD05000, L51010000.FX0000, LVRWB11B4520] Notice of Availability of the Alta East Wind Project Draft Environmental Impact Statement/Environmental Impact Report and Proposed California Desert Conservation Area Plan Amendment, Kern County, CA...

  14. La evaluación psicopedagógica del alumnado con altas capacidades

    OpenAIRE

    Grau Rubio, Claudia

    2012-01-01

    Se describen los instrumentos de evaluación psicopedagógica aplicables al alumnado con altas capacidades. Instrumentos referidos al alumno, al contexto escolar, a las variables socio-familiares y la determinación de las necesidades educativas especiales.

  15. Effect of simvastatin on anti-oxidation and anti-inflammation properties of HDL in apoE-/-mice

    Directory of Open Access Journals (Sweden)

    Di TIAN

    2013-03-01

    Full Text Available Objectives  To investigate the effect of simvastatin on anti-oxidation and anti-inflammation properties of high density lipoprotein (HDL in apoE-/-mice fed with high-fat diet. Methods  Eighteen 8-week old male C57BL/6J mice as blank control group were fed with normal diet, and thirty 8-week old male apoE-/-mice were fed with high-fat diet. Four weeks later, 6 mice in each group were sacrificed. The remaining 24 apoE-/-mice were randomly divided into two groups (12 each: atherosclerosis group (AS group and simvastatin group, while the remaining 12 C57BL/6J mice served as control group. The mice in both control and AS group were fed with the original diet, and the mice in simvastatin group were fed with the same high-fat diet plus simvastatin 5mg/ (kg.d. At the end of the 8th and 16th week, 6 mice were sacrificed in each group. Serum lipid levels, paraoxonase 1 (PON1 activity (arylesterase activity, serum myeloperoxidase (MPO activity, high-density lipoprotein inflammation index (HII and serum hs-CRP levels were determined. The atherosclerotic lesion formation in the aorta was manifested by oil red O staining. Results  At the end of the 8th week, no difference was found in the levels of serum low density lipoprotein cholesterol (LDL-C and high density lipoprotein cholesterol (HDL-C between simvastatin and AS group. At the end of 16th week, the levels of serum LDL-C decreased significantly (P<0.01 and HDL-C increased significantly (P<0.05 in simvastatin group compared with AS group. At the end of the 8th and 16th week, a significant enhancement of the serum PON1 activity but marked decrease in MPO activity, HII, and serum hs-CRP levels were found in simvastatin group compared with that in AS group. The percentage of plaque area (surface area of plaque/ surface area of whole intima in the aorta was significantly smaller in simvastatin group than that in AS group (P<0.05 or P<0.01. Conclusions In addition to lowering LDL-C and elevating HDL

  16. HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization.

    Science.gov (United States)

    Fan, Qiao; Maranville, Joseph C; Fritsche, Lars; Sim, Xueling; Cheung, Chui Ming Gemmy; Chen, Li Jia; Gorski, Mathias; Yamashiro, Kenji; Ahn, Jeeyun; Laude, Augustinus; Dorajoo, Rajkumar; Lim, Tock Han; Teo, Yik-Ying; Blaustein, Robert O; Yoshimura, Nagahisa; Park, Kyu-Hyung; Pang, Chi Pui; Tai, E Shyong; Khor, Chiea Chuen; Wong, Tien Yin; Runz, Heiko; Cheng, Ching-Yu

    2017-12-01

    Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological studies have yielded conflicting results. We investigated the causal role of plasma lipid levels in AMD in multiethnic populations comprising 16 144 advanced AMD cases and 17 832 controls of European descent, together with 2219 cases and 5275 controls of Asian descent, using Mendelian randomization in three models. Model 1 is a conventional meta-analysis which does not account for pleiotropy of instrumental variable (IV) effects. Model 2 is a univariate, inverse variance weighted regression analysis that accounts for potential unbalanced pleiotropy using MR-Egger method. Finally, Model 3 is a multivariate regression analysis that addresses pleiotropy by MR-Egger method and by adjusting for effects on other lipid traits. A 1 standard deviation (SD) higher HDL-cholesterol level was associated with an odds ratio (OR) for AMD of 1.17 (95% confidence interval: 1.07-1.29) in Europeans (P = 6.88 × 10-4) and of 1.58 (1.24-2.00) in Asians (P = 2.92 × 10-4) in Model 3. The corresponding OR estimates were 1.30 (1.09-1.55) in Europeans (P = 3.18 × 10-3) and 1.42 (1.11-1.80) in Asians (P = 4.42 × 10-3) in Model 1, and 1.21 (1.11-1.31) in Europeans (P = 3.12 × 10-5) and 1.51 (1.20-1.91) in Asians (P = 7.61 × 10-4) in Model 2. Conversely, neither LDL-C (Europeans: OR = 0.96, P = 0.272; Asians: OR = 1.02, P = 0.874; Model 3) nor triglyceride levels (Europeans: OR = 0.91, P = 0.102; Asians: OR = 1.06, P = 0.613) were associated with AMD. We also assessed the association between lipid levels and polypoidal choroidal vasculopathy (PCV) in Asians, a subtype of AMD, and found a similar trend for association of PCV with HDL-C levels. Our study shows that high levels of plasma HDL-C are causally associated with an increased risk for advanced AMD in European and

  17. Avaliação da densidade óssea para instalação de mini-implantes Bone density assessment for mini-implants positioning

    Directory of Open Access Journals (Sweden)

    Marlon Sampaio Borges

    2010-12-01

    Full Text Available INTRODUÇÃO: além da espessura da cortical óssea e da largura dos espaços inter-radiculares, a densidade óssea é fator primordial para a eficiência dos mini-implantes usados como recurso de ancoragem. OBJETIVO: nesse estudo, pretendeu-se avaliar a densidade óssea alveolar e basal maxilar e mandibular, em unidades Hounsfield (HU. MÉTODOS: em onze arquivos de imagens tomográficas computadorizadas Cone-Beam, de indivíduos adultos, foram obtidas 660 medidas das densidades ósseas alveolar (corticais vestibular e lingual, do osso medular e basal (maxilar e mandibular. Os valores foram obtidos através do software Mimics 10.01 (Materialise, Bélgica. RESULTADOS: maxila - a densidade da cortical vestibular na faixa de osso alveolar variou de 438 a 948HU, e a lingual de 680 a 950HU; já o osso medular variou de 207 a 488HU; a densidade da cortical vestibular na faixa de osso basal apresentou uma variação de 672 a 1380HU e o osso medular de 186 a 420HU. Mandíbula - a variação do osso na cortical vestibular na faixa de osso alveolar foi de 782 a 1610HU, na cortical lingual alveolar de 610 a 1301HU, e na medular de 224 a 538; a densidade na área basal foi de 1145 a 1363HU na cortical vestibular, e de 184 a 485HU na medular. CONCLUSÕES: a maior densidade óssea na maxila foi observada entre pré-molares na cortical alveolar vestibular. A tuberosidade maxilar foi a região com menor densidade óssea. A densidade óssea na mandíbula foi maior do que na maxila, e observou-se um acréscimo progressivo de anterior para posterior e de alveolar para basalINTRODUCTION: The cortical thickness, the interradicular spaces width and bone density are the key factors for the efficiency of mini-implants as anchorage resources. OBJECTIVES: The objective was to assess the alveolar and basal bone density in maxilla and mandible in Hounsfield units (HU. METHODS: From eleven files of adults computed tomography images were obtained 660 measurements of bone

  18. 76 FR 3881 - Application To Export Electric Energy; TransAlta Energy Marketing (U.S.) Inc.

    Science.gov (United States)

    2011-01-21

    ... Application To Export Electric Energy; TransAlta Energy Marketing (U.S.) Inc. AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: TransAlta Energy Marketing (U... a power marketer for a two-year term using existing international transmission facilities. DOE...

  19. 77 FR 35669 - AltaGas Renewable Energy Colorado LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2012-06-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1875-000] AltaGas Renewable Energy Colorado LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request... of AltaGas Renewable Energy Colorado LLC application for market-based rate authority, with an...

  20. Stress responses of juvenile matrinxã (Brycon amazonicus after transport in a closed system under different loading densities Respostas de estresse de matrinxã (Brycon amazonicus juvenil após transporte em sistema fechado sob diferentes densidades de carga

    Directory of Open Access Journals (Sweden)

    Janessa Sampaio de Abreu

    2008-08-01

    , a temperatura esteve em torno de 32°C, pH 6,5-6,78, a amônia total foi de 1,09-1,7mg L-1, a amônia não-ionizada foi de 3,58-9,33 x 10³mg L-1 e alcalinidade 134-165mg CaCO3 L-1. O cortisol plasmático e a glicose sanguínea aumentaram após o transporte nos peixes em todas as densidades ensaiadas, voltando aos valores controle 24h depois. Os valores de osmolaridade não mudaram logo após o transporte, mas aumentaram 24h depois de modo igual em todas as densidades. O cloreto plasmático diminuiu na chegada, de modo inversamente proporcional à densidade de carga. O hematócrito diminuiu 24h depois da chegada dos peixes, em todas as densidades testadas, mas não houve diferença no número de eritrócitos. Não houve mortalidade até uma semana após o transporte. O matrinxã mostrou ser uma espécie tolerante a altas densidades de carga em embalagens para transporte além de suportar baixos níveis de oxigênio na água.

  1. Relación entre paraoxonasa, otros componentes de HDL y estado inflamatorio en hemodiálisis Relation between paraoxonase activity, other HDL components and inflammatory conditions in hemodialyzed patients

    Directory of Open Access Journals (Sweden)

    Ana Inés González

    2010-12-01

    Full Text Available La enfermedad renal crónica (ERC se asocia estrechamente con un estado pro-inflamatorio, aumento de lipoproteínas ricas en triglicéridos y disminución de HDL. La HDL contiene enzimas antioxidantes asociadas como la paraoxonasa (PON, cuya actividad en ERC se encuentra disminuida. Nuestro objetivo fue evaluar la relación entre la actividad de PON, apoA1, colesterol(col-HDL y Proteína C reactiva-altamente sensible (PCR-as como marcador de inflamación en pacientes en hemodiálisis. Se estudiaron n = 42 pacientes; edad, mediana (rango = 50 (25-67 años; sexo M/F = 22/20; antigüedad de hemodiálisis = 4.4 ± 0.5 años; índice de masa corporal (IMC = 23 ± 0.5 kg/m². Se obtuvo una muestra de sangre después de 12 h de ayuno y se determinaron los parámetros clásicos del perfil lipídico, se midieron los valores de apoproteínas A1 y B, PON a través de su actividad arilesterasa y PCR-as, la cual permitió dividir a los pacientes con PCR-as ≤ 1 (bajo riesgo, rango: 0.1 a 1.0 mg/l y > 1 mg/l (moderado y alto riesgo, 1.1 a 10.7 mg/l. Los niveles de triglicéridos, col-LDL y apoB no fueron diferentes entre los grupos. Los pacientes con PCR-as > 1 presentaron menor col-HDL (40 ± 2 mg/dl y apoA1 (118 ± 4 mg/dl que los pacientes con PCR-as ≤ 1 (50 ± 4 y 133 ± 5, respectivamente; p 1: 90.5 ± 24.0 μmol/ml.min que en PCR-as ≤ 1: 105.2 ± 18.0. Consecuentemente, se obtuvieron correlaciones inversas entre apoA1 y PCR-as, r = -0.381 p = 0.013 y entre PON y PCR-as, r = -0.32, p = 0.042. Además, el aumento de PCR-as correlacionó positivamente con el IMC, r = 0.318, p = 0.042. La disminución de col-HDL, apoA1 y PON en los individuos con mayor estado inflamatorio explicaría, en parte, el aumento de riesgo cardiovascular de estos pacientes, dado los efectos antiinflamatorios de la apoA1 y antioxidantes de la PON.Advanced Chronic Renal Disease (CKD is closely associated with a pro-inflammatory condition, with an increase in triglyceride

  2. Monitorización de movimientos de suelo usando una red de gran densidad de receptores GPS de bajo coste

    OpenAIRE

    Elcano Fuentes, Miguel

    2016-01-01

    RESUMEN: El movimiento de las placas tectónicas, extracciones de gas o agua así como eventos naturales, tales como lluvia fuerte, llevan a deslizamientos de tierra o terremotos. Cuando la superficie de la tierra se mueve durante estos eventos, los edificios y la infraestructura pública también lo hacen. Esto conlleva a serias consecuencias ya que puede requerir de altas inversiones para asegurar la seguridad de los edificios o construcciones dañadas o incluso de su completa reconstrucción. Mu...

  3. Intervalo hídrico ótimo e densidade crítica de um Latossolo Amarelo coeso sob diferentes usos no ecossistema Tabuleiro Costeiro

    Directory of Open Access Journals (Sweden)

    Camila Brasil Dias

    Full Text Available RESUMO Os impactos do uso e do manejo na qualidade física do solo têm sido quantificados, utilizando-se o intervalo hídrico ótimo e a densidade crítica do solo. O objetivo deste trabalho foi determinar o intervalo hídrico ótimo (IHO e a densidade crítica de um Latossolo Amarelo coeso, dos Tabuleiros Costeiros do Recôncavo da Bahia, submetido a diferentes usos e manejo do solo. Foram selecionadas três áreas, sobre solo coeso típico, submetidas aos seguintes usos e manejos: mata nativa (Mata Atlântica; pastagem de Brachiaria decumbens Stapf, em estado de degradação, e cana-de-açúcar, com subsolagem no sulco de plantio. Foram retiradas em cada área 40 amostras com estrutura indeformada, na porção central de cada horizonte (A e AB. Foram determinados nessas amostras, após serem submetidas a dez valores de tensão e pressão, a umidade, a resistência à penetração e a densidade do solo. Na área cultivada com cana, a coleta das amostras foi feita nas linhas de plantio, onde foi realizada a subsolagem. O intervalo hídrico ótimo do horizonte A, da mata, e do Ap, da cana-de-açúcar foram semelhantes e, ambos, maiores que na pastagem. Já no horizonte AB, o IHO da cana-de-açúcar foi maior que o da mata e, o desta, maior que o da pastagem. Os horizontes A e Ap apresentaram valores de densidade crítica maiores que os de AB para todos os usos avaliados. O uso que apresentou maior frequência de valores de densidade do solo acima da densidade crítica foi a pastagem.

  4. Variación de la densidad básica de la madera de Eucalyptus grandis en arboles de siete años de edad.

    Directory of Open Access Journals (Sweden)

    Arango A. Bibiana

    2001-09-01

    Full Text Available En el presente trabajo se estima la variación de la densidad básica de la madera con la altura de los árboles en clones de Eucalyptus grandis de 7 años de edad, seleccionados en plantaciones forestales de la empresa Smurfit Cartón de Colombia localizadas en los municipios de Restrepo, Pereira y Popayán, encontrándose que la densidad decrece desde la base del árbol hacia el nivel del D.A.P y luego, a partir de este aumenta hacia la copa hasta el 75% de la altura total del árbol. De igual manera se establecen correlaciones entre la densidad básica media de la madera en función de las tres zonas de estudio y los diferentes clones. Se comparan tanto las metodologías empleadas para la determinación de la densidad básica (Norma Tappi 258-om-94 y el Método del Máximo Contenido de Humedad como los diferentes tipos de muestras empleadas para la determinación de la misma (muestras tipo disco de madera y muestras de barreno. El rango de variación de la densidad básica media para las muestras tipo disco de madera fue de 0.40 a 059 g/cm3 y para las muestras de barreno fue de 0.38 a 0.55 g/cm3. Respecto a los métodos para la determinación de la densidad básica media de la madera en muestras de barreno, el método del máximo contenido de humedad mostró una subestimación de aproximadamente 3% de la misma en comparación con los valores obtenidos por el método de la balanza hidrostática.

  5. Avaliação dos efeitos da adição de sal e da densidade no transporte de tambaqui

    Directory of Open Access Journals (Sweden)

    Gomes Levy de Carvalho

    2003-01-01

    Full Text Available Os objetivos deste trabalho foram testar a eficiência do sal como redutor de estresse e verificar a melhor densidade de transporte de juvenis de tambaqui (Colossoma macropomun em caixas de plástico adaptadas. No primeiro experimento foram testadas diferentes concentrações de sal de cozinha (NaCl na água; no segundo, o transporte foi realizado por três horas em caixas de plástico de 200 L estocadas com diferentes densidades de peixe, com 8 g de sal/L de água. O cortisol plasmático dos peixes sofreu aumento significativo após o transporte no tratamento sem sal e com 2 g de sal/L de água, retornando para níveis normais após 96 horas. A glicose plasmática dos peixes sofreu aumento após o transporte em todas as concentrações de sal testadas, com exceção da com 8 g/L de água, retornando para níveis normais em 24 horas. Nos peixes transportados no segundo experimento, com 8 g de sal/L de água, não foi verificada mudança significativa no cortisol plasmático, mas a glicose aumentou significativamente em todas as densidades após o transporte, retornando para níveis normais em 24 horas. Houve mortalidade de 11% em uma das repetições da densidade de 200 kg/m³ de água. Para o transporte com 8 g de sal/L de água, a densidade máxima deve ser de 150 kg/m³ de água. Nesta densidade os parâmetros físico-químicos de qualidade de água se mantêm com características adequadas, as respostas ao estresse são mínimas e não há mortalidade.

  6. Stocking density of “Pseudoplatystoma” spp. surubim reared in cages Densidade de estocagem do surubim "Pseudoplatystoma" spp. cultivado em tanque-rede

    Directory of Open Access Journals (Sweden)

    Daniel Vieira Crepaldi

    2009-03-01

    Full Text Available This work aimed to determine the effect of stocking density on the biomass production, final weight, feed conversion and survival rate of Pseudoplatystoma spp. surubim reared in floating net cages under three initial stocking densities. Twelve floating net cages located in a 47-ha reservoir were stocked with 35, 70 and 105 fish/m3 averaging 50 g from April to August 1999. At the end of the experimental period (105 days, the final average weights of the treatments were 197.4, 171.15, and 161.45 g, respectively. The highest final mean weight was reached at the lowest initial density. No significant effects of initial stocking density were observed on survival (95.97, 97.80 and 96.73%, respectively and feed conversion rates (1.49; 1.60 e 1.56; respectively. The final biomass of 87.93, 157.67, and 220.46 kg were affected by the initial stocking density. At higher storage densities, the individual weight gain decreased, but the final biomass increased significantly.Objetivou-se com este trabalho determinar o efeito da densidade de estocagem na produção, no ganho de peso, na conversão alimentar e na sobrevivência do surubim Pseudoplatystoma spp. cultivado em tanques-rede, sob três diferentes densidades de estocagem iniciais. Doze tanques-rede foram instalados em uma represa de 47 ha e estocados com 35, 70 e 105 alevinos de surubim/m3, com peso médio de 50g, no período de abril a agosto de 1999. Ao final de 105 dias de experimento, os pesos finais médios para os tratamentos foram 197,4; 171,15 e 161,45 g, respectivamente. O maior peso médio foi alcançado no tratamento de menor densidade. As sobrevivências (95,97; 97,80 e 96,73%, respectivamente e a conversão alimentar (1,49; 1,60 e 1,56:1, respectivamente não foram afetadas pela densidade de estocagem inicial. As biomassas finais foram 87,93; 157,67 e 220,46 kg, respectivamente, com efeito significativo da densidade de estocagem inicial. Com o aumento da densidade de estocagem, houve redu

  7. A cidade alta em alta? Circuitos e cenários das dinâmicas comerciais do centro velho de Salvador

    Directory of Open Access Journals (Sweden)

    Noora Heinonen

    2008-10-01

    Full Text Available O trabalho pretende analisar os circuitos e cenários das dinâmicas comerciais atuais da cidade alta de Salvador, a antiga zona comercial "nobre" que, após várias fases sucessivas de desenvolvimento nas últimas décadas, ainda hoje constitui a zona comercial mais densa da cidade. Em nível prático, nosso objetivo é caracterizar as dinâmicas: organização das empresas; características pessoais e profissionais dos comerciantes bem como suas percepções e opiniões. Em nível teórico, pretendemos discutir a validade das teorias dualistas das economias urbanas do terceiro mundo, através dos resultados empíricos deste caso específico de uma área total, a cidade alta, que engloba dentro de estruturas comerciais a priori modernas - shopping centers e tradicionais - as ruas comerciais. Enfim, para reforçar o caráter pragmático da pesquisa, nosso objetivo é refletir sobre as dificuldades e, por outro lado, as potencialidades da área. As análises mostram uma cidade alta bastante heterogênea em todos aspectos e internamente hierarquizada. Os shopping centers e a Avenida Sete de Setembro apresentam a maior intensidade das atividades e concentram as empresas de grande porte que servem de elo entre os espaços comerciais. Apesar desta semelhança estrutural entre os shopping centers e certos trechos do comércio de rua, os padrões locacionais e as estratégias das pequenas empresas assim como as características dos comerciantes traduzem uma dissociação dos espaços. A predominância das pequenas empresas e a heterogeneidade qualitativa dos estabelecimentos, os problemas de infra-estrutura de segurança e a falta de dinamismo dos comerciantes de rua destacam-se como as fraquezas da cidade alta. Por outro lado o resgate da história e o leque extremamente variado de atividade de áreas turísticas deverão constituir as bases para o desenvolvimento futuro da área.

  8. DENSIDAD CRÍTICA DE Meloidogyne exigua EN PLANTAS DE ALMÁCIGO DE CAFÉ VARIEDAD CATURRA

    Directory of Open Access Journals (Sweden)

    Mainor Rojas

    2013-01-01

    Full Text Available El objetivo del estudio fue evaluar el efecto de densidad creciente de Meloidogyne exigua sobre el desarrollo de plantas de almácigo. Se trasplantaron plántulas de café variedad caturra a bolsas de polietileno con 1335 cm3 de sustrato desinfectado, para establecer un ensayo con diseño de bloques completos al azar, con 8 repeticiones. Los tratamientos aplicados consistieron de poblaciones iniciales (Pi de 0; 0,125; 0,25; 0,5; 1; 2; 4; 8; 16; 32 y 64 huevos+J2/ cm3 de sustrato, aplicadas un mes después del trasplante. El modelo y=m+(1-m ZP-T aplicado 234 días después del trasplante para la altura, diámetro, número de nudos y peso fresco aéreo, indicó que el límite de tolerancia (T fue de 0,66; 0,06; 0,13 y 0,88 huevos+J2/cm3, respectivamente; la producción mínima relativa (m fue de 0,79; 0,79; 0,33 y 0,54 respectivamente, a Pi iguales o mayores a 64 huevos+J2/cm3. El índice de agallas alcanzó el máximo a partir de una Pi de 2; el pico máximo de nematodos en el suelo y las raíces se alcanzó con Pi entre 2 y 4; mientras la tasa máxima de reproducción fue de 114 con Pi de 0,125. Se concluyó que la densidad crítica fue cercana a cero huevos/cm3 de sustrato como población inicial, y que el almácigo se debe desarrollar libre de nematodos, ya que aún con Pi bajas se puede alcanzar la máxima población en corto tiempo.

  9. Atividade física na vida diária e densidade mineral óssea em mulheres idosas

    Directory of Open Access Journals (Sweden)

    Maria Carrasco

    2015-02-01

    Full Text Available INTRODUÇÃO: o rápido envelhecimento da população contemporânea tem influenciado no desenvolvimento de estratégias para a prevenção da osteoporose em idosos. A atividade física diária é vista como uma possível estratégia para aumentar a massa óssea e ajudar a prevenir a perda óssea em pessoas idosas. No entanto, é essencial saber a quantidade mínima ou a intensidade adequada de atividade física que produza o aumento da massa óssea em mulheres idosas. OBJETIVO: analisar, durante uma semana, a relação entre a quantidade e a intensidade da atividade física diária com a densidade mineral óssea (DMO da mão, por meio da quantificação de atividade física diária em idosas. MÉTODOS: a amostra do estudo foi composta por 24 mulheres (idade 66-78 anos, que realizaram atividade física, durante 7 dias, com um gravador da aceleração dos movimentos do corpo em seu pulso, para uma quantificação individual da atividade física. Para medir a densidade mineral óssea da mão direita foi utilizada a técnica de dupla absorção de raios-X (DXA. RESULTADOS: uma relação significativa entre a prática semanal e o T-score (r = 0,99 e a prática semanal horizontal e o T-score (r = 0,99 foi encontrada no osso normal e no grupo ósseo com osteoporose, respectivamente. A relação entre T-score e a quantidade de atividade física não era clara em ambos os grupos. CONCLUSÃO: na amostra analisada, foi encontrada uma associação positiva entre a maior qualidade do osso da mão e a intensidade mais elevada de atividade física. A combinação de absorciometria acelerometria e de raios-X na mão obteve resultados semelhantes ao encontrados com outros métodos menos acessíveis.

  10. Força muscular e densidade mineral óssea em idosos eutróficos e desnutridos

    Directory of Open Access Journals (Sweden)

    Karla Helena Coelho Vilaça

    2011-12-01

    Full Text Available OBJETIVO: Este estudo teve como objetivo avaliar a associação do estado nutricional com a força muscular de preensão manual e a densidade mineral óssea em idosos do sexo masculino. MÉTODOS: Participaram do estudo 41 idosos do sexo masculino, sendo 20 eutróficos (peso: M=69,6, DP=8,4; índice de massa corporal: M=25,7, DP=2,2 e 21 desnutridos (peso: M=50,9, DP=6,1; índice de massa corporal: M=18,7, DP=1,8, classificados subjetivamente segundo a Mini Avaliação Nutricional. A avaliação antropométrica incluiu peso corporal, altura, circunferência do braço e da panturrilha. A composição corporal foi avaliada pelo método de absorciometria por dupla emissão de Raios X, e a ocorrência de osteoporose foi definida de acordo com os critérios estabelecidos pela Organização Mundial da Saúde. A força muscular foi avaliada pelo dinamômetro de mão. RESULTADOS: O grupo desnutrido apresentou valores expressivamente menores dos parâmetros antropométricos e de com-posição corporal em relação ao grupo eutrófico (p<0,005. Além disso, a ocorrência de osteoporose foi signifi-cativamente maior (p<0,01 no grupo desnutrido em todas as regiões estudadas: colo do fêmur, quadril total e coluna. A força muscular de preensão manual dos idosos desnutridos foi significativamente menor que a dos idosos eutróficos (M=23,1, DP=6,8 e M=30,3, DP=8,4, respectivamente; p<0,005. CONCLUSÃO: A desnutrição está associada à menor força muscular e à diminuição da densidade mineral óssea em idosos do sexo masculino.

  11. Grau de bem-estar relativo de frangos em diferentes densidades de lotação

    Directory of Open Access Journals (Sweden)

    A. Bonamigo

    2011-12-01

    Full Text Available Avaliou-se o impacto da redução da densidade de lotação sobre o bem-estar animal (BEA de frangas de corte, produzidas para abate precoce. Para isso, aos 12 dias de idade, 800 frangas, comerciais, foram distribuídas em baias de 4m²; sendo oito com 10 aves (17,0kg/m² (DL10 e oito com 15 aves (25,5kg/m² (DL15. As condições ambientais foram avaliadas utilizando-se o índice de temperatura e umidade (ITU. Para avaliação de bem-estar, foi construído um etograma; hemograma e testes bioquímicos séricos, desempenho zootécnico e problemas locomotores foram avaliados. Em 43,6% do tempo, o ITU ficou acima do recomendado, e não foram observadas diferenças comportamentais. Diferenças significativas foram observadas em relação aos basófilos, valores de 6,3±2,3 e 4,5±1,8%; triglicerídeos, 158,9±32,9 e 186,3±43,9mg/dL; globulinas, 1,8±0,5 e 1,5±0,4%. Menos peso final ocorreu em DL15, 1,65±0,28kg, 1,69±0,13. Problemas locomotores não diferiram entre tratamento. A consideração conjunta de menor peso final, maiores taxas de triglicerídeos e menores valores de globulinas sugere menor grau de bem-estar em DL15. Índices de ITU e relação heterófilo:linfócito acima do normal sugerem baixo grau de bem-estar em ambas as densidades.

  12. Influencia de los glucocorticoides inhalados sobre la densidad mineral ósea y el metabolismo óseo

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    Fernando D. Saraví

    2000-04-01

    Full Text Available Los glucocorticoides inhalados (GCI constituyen hoy un tratamiento de primera línea del asma bronquial. Los efectos sistémicos de los GCI, como la supresión del eje hipotalámico- hipofisario-adrenal, son en general menores que los de los glucocorticoides orales. Sin embargo, existe el riesgo de efectos adversos sobre el hueso a largo plazo. El objetivo del presente trabajo fue revisar los datos publicados acerca de los efectos de los GCI sobre los marcadores del metabolismo óseo y la densidad mineral ósea en adultos y en pacientes pediátricos. Aunque los estudios examinados no proporcionan resultados uniformes, en términos generales sugieren que los GCI pueden afectar al metabolismo y a la densidad mineral ósea, en particular 1 cuando se administran a dosis elevadas (más de 400 µg/día en niños y más de 800 µg/día en adultos; 2 en pacientes pediátricos, en los que también pueden afectar al crecimiento en estatura; 3 en pacientes cuya ingesta de calcio y vitamina D es inadecuada, y 4 en mujeres postmenopáusicas sin terapia de reposición hormonal. En general, a dosis terapéuticamente equivalentes, la beclometasona tiene mayor efecto deletéreo sobre el hueso que la budesonida, y esta mayor que la fluticasona. Además de la precaución obvia de utilizar la menor dosis eficaz, se proponen como medidas preventivas: 1 la adecuada instrucción sobre el uso de los aerosoles; 2 el uso de cámaras de inhalación; 3 el enjuague bucal tras la administración de GCI, y 4 ajustes o suplementos dietéticos para asegurar una adecuada ingesta de calcio y vitamina D.

  13. Asymptomatic individuals with high HDL-C levels overexpress ABCA1 and ABCG1 and present miR-33a dysregulation in peripheral blood mononuclear cells.

    Science.gov (United States)

    Scherrer, D Z; Zago, V H S; Parra, E S; Avansini, S; Panzoldo, N B; Alexandre, F; Baracat, J; Nakandakare, E R; Quintão, E C R; de Faria, E C

    2015-10-01

    Considering the growing knowledge and perspectives on microRNAs (miRNAs) that control high-density lipoprotein cholesterol (HDL-C) levels and metabolism, this study aimed at evaluating whether hsa-miR-33a and hsa-miR-128a are differentially expressed in peripheral blood mononuclear cells from asymptomatic individuals with low and high HDL-C, as well as at investigating the potential relationships with ATP binding cassete transporter A1 (ABCA1) expression, cholesterol efflux capacity and other parameters related with reverse cholesterol transport. In addition, the associations with cardiovascular risk were investigated by carotid-intima media thickness (cIMT). Asymptomatic volunteers of both genders (n=51) were classified according to HDL-C (mg/dL) in hypoalphalipoproteinemics (hypo, HDL-C ≤3 9), hyperalphalipoproteinemics (hyper, HDL-C ≥ 68) and controls (CTL, HDL-C ≥ 40subgroup of 19 volunteers the cellular cholesterol efflux and HDL composition were determined. Total RNA was extracted from peripheral blood mononuclear cells for relative quantification experiments. Hypo volunteers presented significantly higher levels of triglycerides, VLDL-C and insulin; in addition, HDL size and volume decreased when compared with CTL and hyper. Regarding gene expression analysis, the hyper group presented a decrease of 72% in hsa-miR-33a and higher mRNA expression of ABCA1 and ABCG1 when compared with CTL. No significant differences in hsa-miR-128a expression, cholesterol efflux, cIMT or plaques were found. Further studies are necessary to elucidate the mechanisms underlying the complex miRNA network, regulating cellular cholesterol homeostasis in humans and its clinical repercussions. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS study.

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    Yining Qian

    Full Text Available Intracranial atherosclerotic stenosis (ICAS is an important cause of ischemic stroke worldwide. The role of high-density lipoprotein cholesterol (HDL-C or low-density lipoprotein cholesterol (LDL-C in the development of ICAS remains to be elucidated. In the current study, we investigated the relationship of HDL-C level and the risk of developing ICAS in Chinese patients with acute ischemic stroke.From October 2007 to June 2009, a total of 1,984 consecutive ischemic stroke patients were evaluated for the presence of symptomatic ICAS by magnetic resonance angiography (MRA. Patients were classified into two groups: intracranial steno-occlusion (ICAS group, n = 888 and non-intracranial stenosis (NICAS group, n = 1096. Serum lipid profiles were analyzed and compared between the ICAS and NICAS group.Significantly more patients in ICAS group had low HDL-C level (51.6% than in the NICAS group (42.9%, P<0.001. The observed association remained significant after adjustment for conventional risk factors [(adjusted OR 1.36; 95%CI (1.13-1.63]. Such predictive value of low level HDL-C persisted even when LDL-C was at very low level(<1.8 mmol/L. Patients in the lowest serum HDL-C quartile (<0.96 mmol/L had the highest risk of developing ICAS [adjusted OR 1.52; 95%CI (1.17-1.98] compared to patients in the highest serum HDL-C quartile (≥ 1.32 mmol/L after adjustments for the covariates.Low HDL-C level is strongly associated with the development of ICAS. There was an inverse relationship between the level of HDL-C and the risk of developing ICAS.

  15. Is High Serum LDL/HDL Cholesterol Ratio an Emerging Risk Factor for Sudden Cardiac Death? Findings from the KIHD Study.

    Science.gov (United States)

    Kunutsor, Setor K; Zaccardi, Francesco; Karppi, Jouni; Kurl, Sudhir; Laukkanen, Jari A

    2017-06-01

    Low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c), which are components of total cholesterol, have each been suggested to be linked to the risk of sudden cardiac death (SCD). However, the relationship between LDL-c/HDL-c ratio and the risk of SCD has not been previously investigated. We aimed to assess the associations of LDL-c, HDL-c, and the ratio of LDL-c/HDL-c with the risk of SCD. Serum lipoprotein concentrations were assessed at baseline in the Finnish Kuopio Ischemic Heart Disease prospective cohort study of 2,616 men aged 42-61 years at recruitment. Hazard ratios (HRs) (95% confidence intervals [CI]) were assessed. During a median follow-up of 23.0 years, a total of 228 SCDs occurred. There was no significant evidence of an association of LDL-c or HDL-c with the risk of SCD. In analyses adjusted for age, examination year, body mass index, systolic blood pressure, smoking, alcohol consumption, physical activity, years of education, diabetes, previous myocardial infarction, family history of coronary heart disease, and serum high sensitivity C-reactive protein, there was approximately a two-fold increase in the risk of SCD (HR 1.94, 95% CI 1.21-3.11; p=0.006), comparing the top (>4.22) versus bottom (≤2.30) quintile of serum LDL-c/HDL-c ratio. In this middle-aged male population, LDL-c or HDL-c was not associated with the risk of SCD. However, a high serum LDL-c/HDL-c ratio was found to be independently associated with an increased risk of SCD. Further research is warranted to understand the mechanistic pathways underlying this association.

  16. Plasma triglyceride levels and body mass index values are the most important determinants of prebeta-1 HDL concentrations in patients with various types of primary dyslipidemia.

    Science.gov (United States)

    Tsimihodimos, Vasilis; Gazi, Irene; Filippatos, Theodosios; Kostapanos, Michael; Lagos, Kostantinos; Kostara, Christina; Tellis, Constantinos C; Elisaf, Moses; Tselepis, Alexandros D

    2010-02-01

    Experimental studies have shown that the prebeta-1 subclass of high-density lipoprotein particles (prebeta-1 HDL) may play an important role in the reverse cholesterol transport pathway as the initial acceptors of cellular cholesterol. The aim of the present study was the direct comparison of prebeta-1 HDL values in individuals with various types of primary dyslipidemias. Four hundred and eighty-six unrelated individuals were included in the study. According to their lipid values study participants were subdivided into four groups: control group (n=206), type IIA dyslipidemia group (n=148), type IIB dyslipidemia group (n=49) and type IV dyslipidemia group (n=83). All dyslipidemic patients displayed higher concentrations of prebeta-1 HDL compared to control individuals. However, patients with dyslipidemias characterized by an abnormal catabolism of triglyceride-rich lipoproteins (such as dyslipidemias of type IIB and IV) tend to have higher prebeta-1 HDL values compared to patients with hypercholesterolemia, and this increase is proportional to the degree of hypertriglyceridemia. In addition, patients with metabolic syndrome exhibited significantly higher levels of prebeta-1 HDL compared to individuals that do not fulfill the criteria for the diagnosis of this syndrome. Multiple regression analysis revealed that serum triglyceride concentrations and body mass index (BMI) values were the most important determinants of prebeta-1 HDL levels in our population. All dyslipidemic patients exhibit increased prebeta-1 HDL concentrations as compared to normolipidemic individuals. Whether this increase represents a defensive mechanism against atherosclerosis or it is indicative of impaired maturation of HDL particles and thus of a defective reverse cholesterol transport mechanism remains to be established. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

  17. Estudio del comportamiento durante la sinterización de mezclas WC-Co finas, ultrafinas y nanocristalinas obtenidas por molienda de alta energía

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    Salvador, M. D.

    2008-10-01

    Full Text Available In this work the sintering behaviour of fine, ultrafine and nanocrystalline WC-12Co mixtures obtained by high energy milling, as well as commercial nanopowders, have been studied, in order to evaluate the effect of the particle size and the powder processing, in the densification, microstructural development and mechanical properties of the final product. The consolidation of the mixtures has been made by uniaxial pressing and sintering in vacuum, and by hot isostatic pressing. The sintered materials have been evaluated by measures of density, hardness and indentation fracture toughness, and microstructurally characterized by optical microscopy and scanning and transmission electronic microscopy (SEM and TEM. The results show the improvements in resistant behaviour of the materials obtained from nanocrystalline powders, in spite of the grain growth experienced during the sintering. The best results were obtained for the milling nanocrystalline material, which presents values of hardness higher than 1800 HV.

    En este trabajo se ha estudiado el comportamiento, durante la sinterización, de mezclas WC-12Co finas, ultrafinas y nanométricas obtenidas por molienda de alta energía y de material nanométrico comercial, a fin de evaluar el efecto del tamaño de partícula y del proceso de obtención del polvo en la densificación, desarrollo microestructural y propiedades mecánicas del producto final. La consolidación de las mezclas se ha realizado mediante compactación uniaxial y sinterización en vacío y por compactación isostática en caliente. Los materiales sinterizados se han evaluado mediante medidas de densidad, dureza y tenacidad a fractura por indentación y se han caracterizado microestructuralmente mediante microscopía óptica y microscopía electrónica de barrido y de transmisión. Los resultados obtenidos ponen de manifiesto las mejoras en comportamiento resistente de los materiales obtenidos a partir polvos nanométricos, a

  18. Comportamiento de híbridos de maíz con alta calidad de proteína, por su buen rendimiento y tolerancia al "Achaparramiento"

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    Mauro Sierra-Mac\\u00EDas

    2007-01-01

    Full Text Available Comportamiento de hí bri dos de maíz con al ta calidad de proteína, por su buen rendimiento y tolerancia al “Achapa rramiento”. Con los ob jetivos de conocer el rendimiento y las características agronómicas de híbridos de maíz con alta calidad de pro teí na (QPM e iden ti fi car los que me jor se adapten y presenten tolerancia a la enfermedad “Achaparramiento”, du ran te el ci clo primavera verano 2005 se establecieron experimentos en las localidades de Cotaxtla, municipio de Medellín de Bra vo, La To rrecilla, Municipio de Tlalixcoyan y Zapotal Número Uno, municipio de Ignacio de la Llave, en el estado de Ve racruz. Los ensayos fueron sembrados bajo un diseño alpha látice 9x2 con 18 tratamientos y tres repeticiones, en par ce las de dos sur cos de 5 m de lar go se pa ra dos a 80 cm, con una densidad de 62,500 plantas/ha. Durante el desarrollo del cultivo se registraron las variables: rendimiento de grano, porcentaje de plan tas y mazorcas dañadas por achaparramiento, se ve ri dad del da ño, al tu ra de plan ta y de ma zor ca, días a floración masculina y femenina, aspecto y sa nidad de planta y mazorca, porcentaje de plantas acamadas, porcentaje de mazorcas con mala cobertura y porcentaje de ma zorcas podridas. De los análisis de varianza combinados para: Rendimiento de grano, porcentaje de daño y severidad por achaparramiento en planta y porcentaje de mazorcas con achaparramiento, se encontró diferencia altamente significativa para híbridos (H y para localidades (L. La interacción HxL, excepto para rendimien to de gra no, en el res to de las va ria bles fue sig ni fi ca ti va. Los hí bri dos QPM que re gistraron el mayor rendimiento, toleran cia al achaparramiento y mejores características agronómicas fue ron: (CML264QxCML150xCML491, (CML264Qx CML273QxCML491, (CML144xCML159xCLQ-RCWQ50 y (CML492x CML150xCLQ-RCWQ50.

  19. Heliconia acuminata reproductive success is independent of local floral density O sucesso reprodutivo de Heliconia acuminata é independente da densidade floral local

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    Emilio M. Bruna

    2004-09-01

    Full Text Available Reproductive plants in tropical forests are patchily distributed, with some in large aggregations of reproductive consepecifics while others are relatively isolated. This variation in floral density is hypothesized to have a major effect on plant reproductive success, since individuals in higher density neighborhoods can attract more or higher quality pollinators. We experimentally tested this hypothesis with populations of the understory herb Heliconia acuminata in central Amazonia. We created replicated plots in which reproductive plant density spanned the range of naturally occurring floral neighborhood size, then measured three surrogates of plant fitness in focal plants in each array. There was no significant difference between any of the three floral neighborhood treatments in total seed production, fruit set, or the number of seeds produced per fruit. Pollinator visitation rates to plants in all treatments were extremely low, with many plants not visited at all during the observation period. This could be because H. acuminata's hummingbird pollinators are unable to find the widely scattered reproductive plants, however this hypothesis appears unlikely. Instead, natural flowering plant densities may simply be below the threshold value at which neighborhood effects become important, even in "high-density" aggregations. Nutrient limitation, selective fruit abortion, and reproduction via male rather than female function may also be playing a role. We argue the absence of neighborhood effects may be a general phenomenon in central Amazonian forests, though additional experiments with other plant-pollinator systems are needed to determine the extent to which this hypothesis is supported.Plantas reprodutivas em florestas tropicas são distribuidas em manchas, com algumas em grandes agregações coespecíficas e outras relativamente isoladas. A hipótese é que esta variação na densidade de flores em um local tem um grande efeito no sucesso

  20. Relação das propriedades mecânicas e densidade de postes de madeira de eucalipto com seu estado de deterioração

    OpenAIRE

    Abruzzi,Rafael Colombo; Pires,Marçal Rodrigues; Dedavid,Berenice Anina; Kalil,Silvia Baptista

    2012-01-01

    Este trabalho apresenta correlações obtidas entre propriedades mecânicas, densidade e o estado de deterioração de postes de eucalipto novos e retirados de serviço. O estado de deterioração foi determinado por inspeções em campo de postes da rede de distribuição de energia elétrica no sul do Brasil. Postes em diferentes estados de deterioração foram retirados da rede para os ensaios de flexão estática e medidas de densidade. Os testes mecânicos indicaram que os valores médios da resistência a ...

  1. EFECTO DE LA DENSIDAD DE PLANTACIÓN EN SANDÍA SIN SEMILLA INJERTADA SOBRE BULE (Lagenaria siceraria (Molina Standl.

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    Jesus Lopez Elias

    2010-11-01

    Full Text Available En los últimos años se ha incrementado el interés en sandía injertada sobre portainjertos tolerantes a Fusarium. En virtud de que la densidad de plantación es un factor determinante en el grado de competencia entre las plantas y de que el rendimiento por planta disminuye a medida que la densidad por unidad de superficie se incrementa, el objetivo de este estudio fue evaluar el efecto de tres densidades de plantación, en hileras a 2.0 m de separación con plantas espaciadas a 1.25, 1.55 y 2.00 m, sobre la producción y calidad de sandía sin semilla híbrido ‘Tri-X 313’, injertada sobre bule (Lagenaria siceraria (Molina Standl. híbrido ‘Emphasis’. El experimento se desarrolló utilizando un diseño en bloques completos al azar, con cuatro repeticiones. Las densidades de plantación evaluadas no influyeron sobre la producción de sandía sin semilla, híbrido ‘Tri-X 313’, injertada sobre L. siceraria; Sin embargo, las plantas injertadas mostraron una disminución del rendimiento por superficie con respecto de aquellas sin injertar, que varió del 10 al 24%, por lo que su uso está restingido a suelos con problemas de estrés causado principalmente por enfermedades. El peso promedio del fruto se incrementó en un 10% con el espaciamiento a 2.00 m. Asimismo, el número de frutos por planta disminuyó significativamente a medida que la densidad se incrementó. Los resultados en sandía injertada no fueron positivos por unidad de superficie; sin embargo, se obtuvo mayor producción por planta a menor densidad de plantación (mayor espaciamiento. Dado el incremento en los costos de producción al utilizar plantas injertadas, existe ventaja en el uso de menor densidad de plantación (mayor espaciamiento, pudiendose usar hasta un 50% menos densidad de plantación que en sandía sin injertar, sin afectar significativamente la producción y la

  2. HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function[S

    Science.gov (United States)

    Berisha, Stela Z.; Brubaker, Greg; Kasumov, Takhar; Hung, Kimberly T.; DiBello, Patricia M.; Huang, Ying; Li, Ling; Willard, Belinda; Pollard, Katherine A.; Nagy, Laura E.; Hazen, Stanley L.; Smith, Jonathan D.

    2015-01-01

    HDL functions are impaired by myeloperoxidase (MPO), which selectively targets and oxidizes human apoA1. We previously found that the 4WF isoform of human apoA1, in which the four tryptophan residues are substituted with phenylalanine, is resistant to MPO-mediated loss of function. The purpose of this study was to generate 4WF apoA1 transgenic mice and compare functional properties of the 4WF and wild-type human apoA1 isoforms in vivo. Male mice had significantly higher plasma apoA1 levels than females for both isoforms of human apoA1, attributed to different production rates. With matched plasma apoA1 levels, 4WF transgenics had a trend for slightly less HDL-cholesterol versus human apoA1 transgenics. While 4WF transgenics had 31% less reverse cholesterol transport (RCT) to the plasma compartment, equivalent RCT to the liver and feces was observed. Plasma from both strains had similar ability to accept cholesterol and facilitate ex vivo cholesterol efflux from macrophages. Furthermore, we observed that 4WF transgenic HDL was partially (∼50%) protected from MPO-mediated loss of function while human apoA1 transgenic HDL lost all ABCA1-dependent cholesterol acceptor activity. In conclusion, the structure and function of HDL from 4WF transgenic mice was not different than HDL derived from human apoA1 transgenic mice. PMID:25561462

  3. ESTUDIO TERMOXIDATIVO NO ISOTERMICO POR CALORIMETRÍA DIFERENCIAL DE BARRIDO DE POLIETILENO DE BAJA DENSIDAD FORMULADO CON LIGNINA

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    Irama Piña-Saenz

    2012-01-01

    Full Text Available Se evaluó la capacidad antioxidante de la lignina (LLN en el polietileno de baja densidad (PEBD a través de un método no isotérmico empleando calorimetría diferencial de barrido (DSC. Las muestras bajo estudio, obtenidas de la formulación de PEBD con LLN, se sometieron a tratamientos térmicos a diferentes velocidades de calentamiento (β = 1, 3, 5, 7, 10, 15, 20 ° C/min, en presencia de oxígeno para favorecer la termo-oxidación del material. Se empleó un modelo cinético de degradación termoxidativa isoconversional, ajustada a la ecuación de Arrhenius, para determinar el factor de protección (PF de la lignina en la resina polimérica. Los resultados indican que bajo las formulaciones estudiadas, la lignina presenta una baja capacidad antioxidante en comparación con el Irganox1010. Sin embargo, en las formulaciones que contiene una mezcla de Irganox 1010 y lignina se observó un efecto sinergético en la capacidad antioxidativa de la lignina sobre el aditivo comercial.

  4. Influencia de tres densidades de siembra y cuatro niveles de fertilización en la variedad de maíz INIA 612-Maselba

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    Walker Cubas Pérez

    2013-06-01

    Full Text Available El experimento se realizó el año 2008, en el Campo Experimental San Miguel de la EEA. San Roque del INIA - Loreto, con el objetivo de determinar el efecto de diferentes densidades de siembra y niveles de fertilización nitrogenada en el rendimiento de grano de la variedad de maíz amarillo duro, INIA 612 – MASELBA; en condiciones de suelos aluviales de restinga inundable. Se evaluaron tres densidades de siembra, 0,80m x 0,50m con 2 plantas por sitio (50 000 plantas/ha, 0,8m x 0,60m con 3 plantas (62 500 plantas/ha, y 0,80m x 0,50m con 3 plantas (75 000 plantas/ha; y cuatro niveles de fertilización nitrogenada, 0; 45; 90 y 135 kg de N/ha. Los resultados indican que la mejor densidad, corresponde a 0,80m x 0,50m y 3 plantas por sitio, con rendimiento de 9,2 t/ha de grano y el mejor nivel de fertilización fue de 90 kg N/ha con 8.1 t/ha de grano. Los mejores rendimientos corresponden a las interacciones de 0,80m x 0.50m y 3 plantas por sitio con los niveles de 90 y 135 kg de N/ha; con 9,7 y 9,6 t/ha de grano respectivamente. La interacción densidad por nivel de fertilización nitrogenada, influye en el rendimiento de grano, observándose que la variedad INIA 612 - MASELBA soporta poblaciones de 75 000 plantas/ha.

  5. DESPANOJADO Y DENSIDAD DE POBLACIÓN EN UNA CRUZA SIMPLE ANDROESTÉRIL Y FÉRTIL DE MAÍZ

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    Alejandro Espinosa-Calder\\u00F3n

    2010-01-01

    Full Text Available En este trabajo el objetivo fue determinar el efecto del despanojado en la productividad de cruzas simples de maíz. Se estableció un experimento durante el ciclo primavera - verano 2004, en el Rancho Almaraz de la Facultad de Estudios Superiores Cuautitlán, de la Universidad Nacional Autónoma de México (FESC-UNAM, ubicado en Cuautitlán Izcalli, México, a 2240 msnm. Se utilizó un diseño experimental de campo en bloques completos al azar con tres repeticiones, el análisis estadístico se efectuó en forma factorial, considerando los factores genotipos (2, densidades de población (3 y el tratamiento de despanojado y sin despanojar (2, así como las interacciones. El rendimiento tuvo diferencias altamente significativas para despanojado, así como significancia estadística para genotipos y densidad de población y la interacción densidad de población x despanojado. La cruza simple versión androestéril en promedio rindió 8873 kg/ha, superior estadísticamente (17,9% a la versión fértil que produjo 7521 kg/ha. La densidad de población de 80 000 plantas/ha con 9640 kg/ha, superó estadísticamente al rendimiento obtenido con 50 000 plantas/ha (7193 kg/ha. El testigo sin despanojar (9429 kg/ha superó estadísticamente al despanojado.

  6. URBANIZAÇÃO EFETIVA E DENSIDADE DE DOMICÍLIOS NA REGIÃO OCEÂNICA DE NITERÓI (RJ ENTRE 1976 E 2010

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    Thiago Henriques Fontenelle

    2013-03-01

    Full Text Available A Região Oceânica do município de Niterói (RJ tem sido objeto de intensa especulação imobiliária nas últimas décadas, associando o ideário de paisagens naturais e qualidade de vida a um modelo de habitações predominantemente voltado para população de alto padrão aquisitivo. Neste sentido, este trabalho objetiva analisar a expansão tanto do perímetro urbano como da densidade de domicílios da região no período entre 1976 e 2010, associando ainda a situação atual com o zoneamento urbano-ambiental vigente. A análise histórica, a geoestatística e um conjunto variado de geotecnologias foram as principais ferramentas utilizadas para produção e análise de dados. Em conjunto com estas ferramentas, é proposta uma metodologia alternativa de tratamento de dados censitários e avaliação de densidades de domicílios por unidade de área. Os resultados demonstram o crescimento de 112% da área urbanizada da Região Oceânica, enquanto o número de domicílios cresceu na ordem de 600%, remontando ao processo interligado de avanço tanto via expansão em área quanto via aumento de densidade. Em comparação com o zoneamento, há esgotamento para incorporação de novas áreas perimetrais, o que aponta para um aprofundamento ainda maior do aumento de densidades demográficas nas próximas décadas assim como da pressão sobre os geossistemas costeiros.

  7. Efeito da densidade máxima teórica na dosagem e no comportamento mecânico de mistura asfáltica tipo CBUQ

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    Kamilla Lima Vasconcelos

    2009-12-01

    Full Text Available

    A partir da densidade aparente dos agregados, da densidade aparente do corpo-de-prova compactado e da densidade máxima teórica (DMT determinam-se as características volumétricas de uma mistura asfáltica e, em vários métodos, sua dosagem quanto ao teor de ligante a ser empregado. Diferentes procedimentos na determinação da DMT podem levar a resultados distintos, acarretando em parâmetros volumétricos também distintos. No Brasil, a DMTé comumente calculada através de uma ponderação das densidades reais dos materiais constituintes da mistura. Neste trabalho, além do cálculo da DMT, são investigados dois procedimentos de laboratório para sua determinação: (i norma americana ASTM D 2041, que utiliza uma bomba de vácuo (método Rice e, (ii método utilizando querosene. São discutidas possíveis diferenças nos valores de DMT obtidos pelos procedimentos, avaliando a influência das diferenças nos parâmetros volumétricos e, conseqüentemente, na escolha do teor de projeto. Por fim, o comportamento mecânico das misturas cujo teor de ligante foi determinado pelos três métodos foi avaliado por meio dos ensaios de resistência à tração, módulo de resiliência e vida de fadiga a tensão controlada.

  8. Participação do colmo principal e dos afilhos na produtividade do arroz irrigado, em função da densidade de semeadura

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    Eduardo do Valle Lima

    2010-01-01

    Full Text Available Entre as práticas culturais a serem consideradas na implantação da cultura do arroz destaca-se a densidade de semeadura, que deve estabelecer, em grande parte, a participação do colmo principal e dos afilhos nos componentes da produção, possibilitando a obtenção da máxima produtividade. O trabalho teve como objetivo avaliar a participação do colmo principal e dos afilhos na produtividade de grãos de arroz, cv. IAC 102, no sistema irrigado por inundação, em função da densidade de semeadura. O experimento foi desenvolvido sob túnel plástico, em Botucatu (SP, em caixas d'água de cimento amianto de 500 L, contendo Neossolo Flúvico Ta Eutrófico, com profundidade de 30 cm. O delineamento experimental foi o inteiramente casualizado, com quatro repetições. As densidades de semeadura foram: 100, 200, 300, 400, 500 e 600 sementes viáveis por m², em 4 linhas de 1 m por caixa, espaçadas com 20 cm. A elevação da densidade de semeadura diminui o afilhamento e proporciona a maior participação dos colmos principais, porém, não resultando em incremento de produtividade, devido à plasticidade das plantas de arroz, que proporciona o ajustamento dos componentes da produção.

  9. Distribución espacial, composición y densidad de edafofauna en hojarasca de bosque y cafetal (Montenegro, Colombia

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    Diana Marcela Rueda-Ramírez

    2016-05-01

    Full Text Available Se determinaron los cambios en composición, densidad y distribución espacial de la edafofauna de hojarasca entre dos usos de suelo (cafetal y bosque subandino para entender el efecto del uso de suelo. Asimismo, se establecieron las relaciones entre las variables de la edafofauna y atributos de la hojarasca. Se colectaron muestras de hojarasca superficial durante la época seca y se extrajo la edafofauna, manualmente y mediante embudos Berlese modificados. Esta se identificó hasta el menor nivel taxonómico posible y se clasificó en grupos funcionales. La composición faunística fue diferente entre los usos de suelo. La similitud en la composición fue menor al 50 % en dos de los tres grupos funcionales encontrados, pero la densidad total no presentó diferencias. En general hubo coeficientes de variación altos en la densidad faunística intermuestral para los diferentes grupos taxonómicos y, en consecuencia, una baja detectabilidad del patrón espacial. Sin embargo, se detectó un patrón espacial en la abundancia para Coleoptera, larvas de Diptera y biomasa de hojarasca, en el cafetal. La estructura fue más difícil de detectar en bosque, por los pequeños parches en este. La varianza de la abundancia fue mayor en el cafetal, para todos los grupos, excepto Acaridida y Formicidae. La densidad de Formicidae aumentó al hacerlo la humedad de la hojarasca, pero solo en cafetal. Se concluye que el establecimiento del cafetal afecta de manera diferencial a taxones y grupos funcionales de la edafofauna. Esto sienta las bases para definir los efectos del cambio de uso de suelo y los factores ambientales asociados con la distribución espacial de la edafofauna.

  10. Efeitos de regulador de crescimento, controle de doenças e densidade de semeadura na qualidade industrial de grãos de arroz

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    Sofiatti Valdinei

    2006-01-01

    Full Text Available O objetivo foi avaliar o efeito da aplicação do regulador de crescimento ethephon visando à uniformidade de floração e maturação e o controle de doenças de final de ciclo da cultura do arroz. Foi utilizado o fungicida tebuconazole e a avaliou-se a qualidade industrial de grãos das cultivares IRGA 417 e El Paso L 144, em duas densidades de semeadura. O experimento consistiu de uma combinação fatorial (2x2x4 de duas cultivares (IRGA 417 e El Paso L 144, duas densidades de semeadura (50 e 150kg ha-1, e quatro tratamentos foliares (1-testemunha, 2-ethephon, 3-fungicida, 4-ethephon + fungicida, em um delineamento experimental de blocos ao acaso com três repetições. Foi avaliado o percentual de grãos inteiros, e de grãos com gessamento parcial. O percentual de grãos inteiros foi similar em todos os tratamentos, exceto para o tratamento químico com ethephon + fungicida na cultivar IRGA 417, que apresentou menor percentagem de grãos inteiros. Para