Sample records for alpha reactions

  1. Astrophysical reaction rate for $\\alpha(\\alpha n,\\gamma)$

    CERN Document Server

    Sumiyoshi, K; Goko, S; Kajino, T


    We study the astrophysical reaction rate for the formation of $^{9}$Be through the three body reaction $\\alpha(\\alpha n,\\gamma)$. This reaction is one of the key reactions which could bridge the mass gap at A = 8 nuclear systems to produce intermediate-to-heavy mass elements in alpha- and neutron-rich environments such as r-process nucleosynthesis in supernova explosions, s-process nucleosynthesis in asymptotic giant branch (AGB) stars, and primordial nucleosynthesis in baryon inhomogeneous cosmological models. To calculate the thermonuclear reaction rate in a wide range of temperatures, we numerically integrate the thermal average of cross sections assuming a two-steps formation through a metastable $^{8}$Be. Off-resonant and on-resonant contributions from the ground state in $^{8}$Be are taken into account. As input cross section, we adopt the latest experimental data by photodisintegration of $^{9}$Be with laser-electron photon beams, which covers all relevant resonances in $^{9}$Be. We provide the reactio...

  2. Alpha resonant scattering for astrophysical reaction studies

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, H.; Kahl, D.; Nakao, T. [Center for Nuclear Study (CNS), University of Tokyo, RIKEN campus, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Wakabayashi, Y.; Kubano, S. [The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Hashimoto, T. [Research Center for Nuclear Physics (RCNP), Osaka University, 10-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Hayakawa, S. [Istituto Nazionale Fisica Nucleare - Laboratori Nazionali del Sud (INFN-LNS), Via S. Sofia 62, 95125 Catania (Italy); Kawabata, T. [Department of Physics, Kyoto University, Kita-Shirakawa, Kyoto 606-8502 (Japan); Iwasa, N. [Department of Physics, Tohoku University, Aoba, Sendai, Miyagi 980-8578 (Japan); Teranishi, T. [Department of Physics, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581 (Japan); Kwon, Y. K. [Institute for Basic Science, 70, Yuseong-daero 1689-gil, Yuseong-gu, Daejeon 305-811 (Korea, Republic of); Binh, D. N. [30 MeV Cyclotron Center, Tran Hung Dao Hospital, Hoan Kiem District, Hanoi (Viet Nam); Khiem, L. H.; Duy, N. G. [Institute of Physics, Vietnam Academy of Science and Technology, 18 Hong Quoc Viet, Nghia do, Hanoi (Viet Nam)


    Several alpha-induced astrophysical reactions have been studied at CRIB (CNS Radioactive Ion Beam separator), which is a low-energy RI beam separator at Center for Nuclear Study (CNS) of the University of Tokyo. One of the methods to study them is the α resonant scattering using the thick-target method in inverse kinematics. Among the recent studies at CRIB, the measurement of {sup 7}Be+α resonant scattering is discussed. Based on the result of the experiment, we evaluated the contributions of high-lying resonances for the {sup 7}Be(α,γ) reaction, and proposed a new cluster band in {sup 11}C.

  3. Non-resonant triple alpha reaction rate at low temperature

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, T.; Tamii, A.; Aoi, N.; Fujita, H.; Hashimoto, T.; Miki, K.; Ogata, K. [Research Center for Nuclear Physics, Osaka University, Ibaraki, Osaka 567-0047 (Japan); Carter, J.; Donaldson, L.; Sideras-Haddad, E. [Schools of Physics, University of Witwatersrand, Johannesburg 2050 (South Africa); Furuno, T.; Kawabata, T. [Departments of Physics, Kyoto University, Sakyo, Kyoto, 606-8502 (Japan); Kamimura, M. [RIKEN Nishina Center, Wako, Saitama, 351-0198 (Japan); Nemulodi, F.; Neveling, R.; Smit, F. D.; Swarts, C. [iThemba Laboratory for Accelerator Based Sciences Somerset, West, 7129 (South Africa)


    Our experimental goal is to study the non-resonant triple alpha reaction rate at low temperture (T < 10{sup 8} K). The {sup 13}C(p,d) reaction at 66 MeV has been used to probe the alpha-unbound continuum state in {sup 12}C just below the 2{sup nd} 0{sup +} state at 7.65 MeV. The transition strength to the continuum state is predicted to be sensitive to the non-resonant triple alpha reaction rate. The experiment has been performed at iThemba LABS. We report the present status of the experiment.

  4. On the 14C(alpha,gamma) reaction rate

    CERN Document Server

    Johnson, E D; Mitchell, J; Miller, L; Kemper, K W


    The 14C(alpha,gamma) reaction rate at temperatures below 0.3 GK depends on the properties of two near threshold resonances in 18O, the 1- at 6.198 MeV and the 3- at 6.404 MeV. The alpha+14C Asymptotic Normalization Coefficients (ANCs) for these resonances were determined using the alpha-transfer reactions 14C(7Li,t) and 14C(6Li,d) at sub-Coulomb energies. The 14C(alpha,gamma) reaction rate at low temperatures has been evaluated. Implications of the new reaction rate on the evolution of accreting helium white dwarfs and on the nucleosynthesis of low mass stars during the asymptotic giant branch (AGB) phase are discussed.

  5. Benchmarking the External Surrogate Ratio Method using the (alpha,alpha' f) reaction at STARS

    Energy Technology Data Exchange (ETDEWEB)

    Lesher, S R; Bernstein, L A; Ai, H; Beausang, C W; Bleuel, D; Burke, J T; Clark, R M; Fallon, P; Gibelin, J; Lee, I Y; Lyles, B F; Macchiavelli, A O; McMahan, M A; Moody, K J; Norman, E B; Phair, L; Rodriguez-Vieitez, E; Wiedeking, M


    We measured the ratio of the fission probabilities of {sup 234}U* relative to {sup 236}U* formed via an ({alpha},{alpha}{prime}) direct reactions using the STARS array at the 88-inch cyclotron at the Lawrence Berkeley National Laboratory. This ratio has a shape similar to the ratio of neutron capture probabilities from {sup 233}U(n; f) and {sup 235}U(n; f), indicating the alpha reactions likely formed a compound nucleus. This result indicates that the ratios of fission exit channel probabilities for two actinide nuclei populated via ({alpha}, {alpha}{prime}) can be used to determine an unknown fission cross section relative to a known one. The validity of the External Surrogate Ratio Method (ESRM) is tested and the results support the conclusions of Burke et al. [1].

  6. Recoil-alpha-fission and recoil-alpha-alpha-fission events observed in the reaction Ca-48 + Am-243

    CERN Document Server

    Forsberg, U; Andersson, L -L; Di Nitto, A; Düllmann, Ch E; Gates, J M; Golubev, P; Gregorich, K E; Gross, C J; Herzberg, R -D; Hessberger, F P; Khuyagbaatar, J; Kratz, J V; Rykaczewski, K; Sarmiento, L G; Schädel, M; Yakushev, A; Åberg, S; Ackermann, D; Block, M; Brand, H; Carlsson, B G; Cox, D; Derkx, X; Dobaczewski, J; Eberhardt, K; Even, J; Fahlander, C; Gerl, J; Jäger, E; Kindler, B; Krier, J; Kojouharov, I; Kurz, N; Lommel, B; Mistry, A; Mokry, C; Nazarewicz, W; Nitsche, H; Omtvedt, J P; Papadakis, P; Ragnarsson, I; Runke, J; Schaffner, H; Schausten, B; Shi, Y; Thörle-Pospiech, P; Torres, T; Traut, T; Trautmann, N; Türler, A; Ward, A; Ward, D E; Wiehl, N


    Products of the fusion-evaporation reaction Ca-48 + Am-243 were studied with the TASISpec set-up at the gas-filled separator TASCA at the GSI Helmholtzzentrum f\\"ur Schwerionenforschung. Amongst the detected thirty correlated alpha-decay chains associated with the production of element Z=115, two recoil-alpha-fission and five recoil-alpha-alpha-fission events were observed. The latter are similar to four such events reported from experiments performed at the Dubna gas-filled separator. Contrary to their interpretation, we propose an alternative view, namely to assign eight of these eleven decay chains of recoil-alpha(-alpha)-fission type to start from the 3n-evaporation channel 115-288. The other three decay chains remain viable candidates for the 2n-evaporation channel 115-289.

  7. Probing surface distribution of $\\alpha$-cluster in $^{20}$Ne via $\\alpha$-transfer reaction

    CERN Document Server

    Fukui, Tokuro; Suhara, Tadahiro; Kanada-En'yo, Yoshiko; Ogata, Kazuyuki


    Direct evidence of the $\\alpha$-cluster development in bound states has not been obtained yet although a number of experimental studies were carried out to extract the information of the clustering. In particular in conventional analyses of $\\alpha$-transfer reactions, there exist a few significant problems on reaction models, which are insufficient to qualitatively discuss the cluster structure. We aim to verify the development of the $\\alpha$-cluster structure from observables. As the first application, it is argued to extract the spatial information of the cluster structure of the $^{20}$Ne nucleus in its ground state through the cross section of the $\\alpha$-transfer reaction $^{16}$O($^6$Li,~$d$)$^{20}$Ne. For the analysis of the transfer reaction, we work with the coupled-channels Born approximation (CCBA) approach, in which the breakup effect of $^6$Li is explicitly taken into account by means of the continuum-discretized coupled-channels method (CDCC) based on the three-body $\\alpha + d + {}^{16}$O mo...

  8. Three-Body Model Analysis of Subbarrier alpha Transfer Reaction

    CERN Document Server

    Fukui, Tokuro; Yahiro, Masanobu


    Subbarrier alpha transfer reaction 13C(6Li,d)17O(6.356 MeV, 1/2+) at 3.6 MeV is analyzed with a alpha + d + 13C three-body model, and the asymptotic normalization coefficient (ANC) for alpha + 13C --> 17O(6.356 MeV, 1/2+), which essentially determines the reaction rate of 13C(alpha,n)16O, is extracted. Breakup effects of 6Li in the initial channel and those of 17O in the final channel are investigated with the continuum-discretized coupled-channels method (CDCC). The former is found to have a large back-coupling to the elastic channel, while the latter turns out significantly small. The transfer cross section calculated with Born approximation to the transition operator, including breakup states of 6Li, gives (C_{alpha 13C}{17O*})^2 =1.03 \\pm 0.29 fm^{-1}. This result is consistent with the value obtained by the previous DWBA calculation.

  9. [Interferon alpha antibodies show no cross reactions with typical autoantibodies]. (United States)

    Görg, S; Klouche, M; Wilhelm, D; Kirchner, H


    Patients treated with natural human interferon alpha develop anti-interferon antibodies (IFN-AB) only in very rare cases. By contrast, patients with autoimmune disorders are able to generate high-titered IFN-AB against endogenous interferon alpha. One explanation for the development of auto-IFN-AB could be cross-reactivity with typical autoimmune antigens. We investigated the cross-reactivity of 3 high-titered IgG IFN-AB of female autoimmune patients (aged 32, 36, 74 years; two severe cases of SLE, one case of autoimmune thyroiditis) as well as 25 low-titered natural IgM IFN-AB of healthy blood donors (aged 19-48 years). Typical autoimmune antigens including dsDNA, ENA, as well as natural interferon beta and recombinant interferon gamma are not able to inhibit binding of IFN-AB to interferon alpha in an ELISA test system. Preincubation of sera containing either dsDNA antibodies (dsDNA-AB) (24 patients), thyroid peroxidase (TPO-AB) (9 patients) or thyroglobulin (TG-AB) (12 patients) with interferon alpha resulted in no change in the respective autoantibody titer. These data suggest that there is no cross-reactivity between IFN-alpha-AB and dsDNA-AB, TPO-AB or TG-AB. Thus, an explanation for the occurrence of IFN-AB in autoimmune disorders cannot be found in a cross-reaction between interferon alpha with typical autoimmune antigens.

  10. $\\alpha$-scattering and $\\alpha$-induced reaction cross sections of $^{64}$Zn at low energies

    CERN Document Server

    Ornelas, A; Gyürky, Gy; Elekes, Z; Fülöp, Zs; Halász, Z; Kiss, G G; Somorjai, E; Szücs, T; Takács, M P; Galaviz, D; Güray, R T; Korkulu, Z; Özkan, N; Yalçın, C


    Background: alpha-nucleus potentials play an essential role for the calculation of alpha-induced reaction cross sections at low energies in the statistical model... Purpose: The present work studies the total reaction cross section sigma_reac of alpha-induced reactions at low energies which can be determined from the elastic scattering angular distribution or from the sum over the cross sections of all open non-elastic channels. Method: Elastic and inelastic 64Zn(a,a)64Zn angular distributions were measured at two energies around the Coulomb barrier at 12.1 MeV and 16.1 MeV. Reaction cross sections of the (a,g), (a,n), and (a,p) reactions were measured at the same energies using the activation technique. The contributions of missing non-elastic channels were estimated from statistical model calculations. Results: The total reaction cross sections from elastic scattering and from the sum of the cross sections over all open non-elastic channels agree well within the uncertainties. This finding confirms the cons...

  11. Li production in alpha-alpha reactions. [relation to gamma ray observation (United States)

    Kozlovsky, B.; Ramaty, R.


    The cross section for Li-7 production in alpha-alpha reactions is shown to be increased by about a factor of 2 due to the excitation levels of Li-7 and Be-7 at 478 keV and 431 keV, respectively. The cross section for Li-6 production, however, remains the same as calculated on the basis of the detailed balance principle. The lines at 478 keV and 431 keV may link Li-7 production to feasible gamma-ray observations.

  12. Study of $\\boldsymbol{(\\alpha,p)}$ and $\\boldsymbol{(\\alpha,n)}$ reactions with a Multi-Sampling Ionization Chamber

    CERN Document Server

    Avila, M L; Almaraz-Calderon, S; Ayangeakaa, A D; Dickerson, C; Hoffman, C R; Jiang, C L; Kay, B P; Lai, J; Nusair, O; Pardo, R C; Santiago-Gonzalez, D; Talwar, R; Ugalde, C


    A large number of $(\\alpha,p)$ and $(\\alpha,n)$ reactions are known to play a fundamental role in nuclear astrophysics. This work presents a novel technique to study these reactions with the active target system MUSIC whose segmented anode allows the investigation of a large energy range of the excitation function with a single beam energy. In order to verify the method, we performed a direct measurements of the previously measured reactions $^{17}$O$(\\alpha,n)^{20}$Ne, $^{23}$Na$(\\alpha,p)^{26}$Mg, and $^{23}$Na$(\\alpha,n)^{26}$Al. These reactions were investigated in inverse kinematics using $^{4}$He gas in the detector to study the excitation function in the range of about 2 to 6 MeV in the center of mass. We found good agreement between the cross sections of the $^{17}$O$(\\alpha,n)^{20}$Ne reaction measured in this work and previous measurements. Furthermore we have successfully performed a simultaneous measurement of the $^{23}$Na$(\\alpha,p)^{26}$Mg and $^{23}$Na$(\\alpha,n)^{26}$Al reactions.

  13. First studies of the (8)B(alpha,p)(11)C reaction

    NARCIS (Netherlands)

    Rehm, KE; Jiang, CL; Greene, JP; Henderson, D; Janssens, RVF; Moore, EF; Mukherjee, G; Pardo, RC; Pennington, T; Schiffer, JP; Sinha, S; Tang, XD; Siemssen, RH; Jisonna, L; Segel, RE; Wuosmaa, AH


    The (8)B(alpha,p)(11)C reaction is part of the network that can bypass the triple a process leading to the production of (12)C. We have measured the astrophysical reaction rate for this reaction by studying the inverse (11)C(p,alpha)(8)B process. The radioactive (11)C beam was produced via the p((11

  14. Quantum three-body calculation of the nonresonant triple-\\alpha reaction rate at low temperatures

    CERN Document Server

    Ogata, Kazuyuki; Kamimura, Masayasu


    The triple-\\alpha reaction rate is re-evaluated by directly solving the three-body Schroedinger equation. The resonant and nonresonant processes are treated on the same footing using the continuum-discretized coupled-channels method for three-body scattering. Accurate description of the \\alpha-\\alpha nonresonant states significantly quenches the Coulomb barrier between the two-\\alpha's and the third \\alpha particle. Consequently, the \\alpha-\\alpha nonresonant continuum states below the resonance at 92.04 keV, i.e., the ground state of 8Be, give markedly larger contribution at low temperatures than in foregoing studies. We find about 20 orders-of-magnitude enhancement of the triple-\\alpha reaction rate around 10^7 K compared to the rate of the NACRE compilation.

  15. Alpha-resonance structure in $^{11}$C studied via resonant scattering of $^{7}$Be+$\\alpha$ and $^{7}$Be($\\alpha$, $p$) reaction

    CERN Document Server

    Yamaguchi, H; Wakabayashi, Y; Kubono, S; Hashimoto, T; Hayakawa, S; Kawabata, T; Iwasa, N; Teranishi, T; Kwon, Y K; Binh, D N; Khiem, L H; Duy, N N


    The resonance structure in $^{11}$C is particularly of interest with regard to the astrophysical $^{7}$Be($\\alpha$, $\\gamma$) reaction, relevant at high temperature, and to the $\\alpha$-cluster structure in $^{11}$C. The measurement was to determine unknown resonance parameters for the high excited states of $^{11}$C. In particular, the $\\alpha$ decay width can be useful information to discuss $\\alpha$ cluster structure in $^{11}$C. New measurements of the $^{7}$Be+$\\alpha$ resonant scattering and the $^{7}$Be($\\alpha$, $p$)$^{10}$B reaction in inverse kinematics were performed for center-of-mass energy up to 5.5 MeV, and the resonances at excitation energies of 8.9--12.7 MeV in the compound $^{11}$C nucleus were studied. Inelastic scattering of $^{7}$Be+$\\alpha$ and the $^{7}$Be($\\alpha$, $p_1$)$^{10}$B$^*$ reaction were also studied with a simultaneous $\\gamma$-ray measurement. The measurements were performed at the low-energy RI beam facility CRIB (CNS Radioactive Ion Beam separator) of the Center for Nucl...

  16. Experimental study of the cross-sections of alpha-particle induced reactions on $^{209}$Bi

    CERN Document Server

    Hermanne, A; Shubin, Yu N; Szucs, Z; Takács, S; Tarkanyi, F; 10.1016/j.apradiso.2005.01.015


    alpha -particle-induced nuclear reactions for generation of /sup 211 /At used in therapeutic nuclear medicine and possible contaminants were investigated with the stacked foil activation technique on natural bismuth targets up to E/sub alpha /=39 MeV. Excitation functions are reported for the reactions /sup 209/Bi( alpha ,2n)/sup 211/At, /sup 209/Bi( alpha ,3n)/sup 210/At and /sup 209/Bi( alpha , x)/sup 210/Po. Results obtained from direct alpha -emission measurements and gamma -spectra from decay products are compared and correspond well with earlier literature values. Thick target yields have been deduced from the experimental cross-sections and optimised production pathways for minimal contamination are presented. A comparison with the results of the theoretical model code ALICE-IPPE is discussed.

  17. New Astrophysical Reaction Rate for the $^{12}\\textrm{C}(\\alpha,\\gamma)^{16}\\textrm{O}$ Reaction

    CERN Document Server

    An, Z D; Fan, G T; Li, Y J; Chen, Z P; Sun, Y Y


    A new astrophysical reaction rate for $^{12}$C($\\alpha,\\gamma$)$^{16}$O has been evaluated on the basis of a global R-matrix fitting to the available experimental data. The reaction rates of $^{12}$C($\\alpha,\\gamma$)$^{16}$O for stellar temperatures between 0.04 $\\leq$ $T_9$ $\\leq$ 10 are provided in a tabular form and by an analytical fitting expression. At $T_9$ = 0.2, the reaction rate is (7.83 $\\pm$ 0.35)$\\times10^{15}$ $\\rm{cm^3 mol^{-1} s^{-1}}$, where stellar helium burning occurs.

  18. Evolutionary implications of the new triple-alpha nuclear reaction rate for low mass stars

    CERN Document Server

    Dotter, Aaron


    Context: Ogata et al. (2009; hereafter OKK) presented a theoretical determination of the triple-alpha nuclear reaction rate. Their rate differs from the NACRE rate by many orders of magnitude at temperatures relevant for low mass stars. Aims: We explore the evolutionary implications of adopting the OKK triple-alpha reaction rate in low mass stars and compare the results with those obtained using the NACRE rate. Methods: The triple-alpha reaction rates are compared by following the evolution of stellar models at 1 and 1.5 Msol with Z=0.0002 and Z=0.02. Results: Results show that the OKK rate has severe consequences for the late stages of stellar evolution in low mass stars. Most notable is the shortening--or disappearance--of the red giant phase. Conclusions: The OKK triple-alpha reaction rate is incompatible with observations of extended red giant branches and He burning stars in old stellar systems.

  19. Catalytic enantioselective Michael addition reactions of alpha-nitroesters to alpha,beta-unsaturated ketones

    NARCIS (Netherlands)

    Keller, E; Veldman, N; Spek, AL; Feringa, BL


    Enantioselective Michael additions of alpha-nitroesters 2a-d with alpha,beta-unsaturated ketones were carried out in the presence of a catalytic amount of chiral Al-Li-(R,R')-2,2'-dihydroxy-1,1'-binaphthyl ('AlLiBINOL') complex prepared in situ from LiAlH4 and 2.45 equiv. of (R,R')-BINOL. The enanti

  20. Alpha cluster states in light nuclei populated through the (6Li,d) reaction

    Energy Technology Data Exchange (ETDEWEB)

    Borello-Lewin, Thereza; Rodrigues, M.R.D.; Horodynski-Matsushigue, L.B.; Duarte, J.L.M.; Rodrigues, C.L.; Souza, M.A. [Universidade de Sao Paulo (IF/USP), SP (Brazil). Inst. de Fisica; Cunsolo, A.; Cappuzzello, F. [Universita di Catania (Italy). Istituto Nazionale di Fisica Nucleare. Lab. Nazionali del Sud; Ukita, Gilberto Mitsuo [Universidade de Santo Amaro (UNISA), Sao Paulo, SP (Brazil). Fac. de Psicologia


    Full text: The alpha cluster correlation is an important concept in the nuclear physics of light nuclei. The main purpose of the research program in progress is the investigation of the alpha clustering phenomenon in (x{alpha}) and(x{alpha}+{nu}) nuclei through the ({sup 6}Li,d) alpha transfer reaction. In fact, there is scarce experimental information on the subject, in particular associated with resonant states predicted near (x{alpha}) and (x{alpha}+{nu}) thresholds. Measurements of the {sup 12},{sup 13}C({sup 6}Li,d) {sup 16},{sup 17}O reactions, at an incident energy of 25.5 MeV, have been performed employing the Sao Paulo Pelletron-Enge Split-Pole facility and the nuclear emulsion detection technique. The work is under way and an experimental energy resolution of 30 keV was obtained. Near the (4{alpha}) breakup threshold in {sup 16}O, three narrow alpha resonances, not previously measured, were detected, revealing important {alpha} + {sup 12}C(G.S.) components. One of these resonances corresponds to the known 0{sup +} state at 15.1 MeV[5] of excitation that has probably, according to Funaki et al., the gas like configuration of the 4{alpha} condensate state, with a very dilute density and a large component of {alpha} + {sup 12}C(Hoyle) configuration. As was already mentioned, our experimental information points to the necessity of including the {alpha} + {sup 12}C(G.S.) component in the wave function. (author)

  1. Reaction rates for the s-process neutron source 22Ne+{\\alpha}

    CERN Document Server

    Longland, Richard; Karakas, Amanda I


    The 22Ne({\\alpha},n)25Mg reaction is an important source of neutrons for the s-process. In massive stars responsible for the weak component of the s-process, 22Ne({\\alpha},n)25Mg is the dominant source of neutrons, both during core helium burning and in shell carbon burning. For the main s-process component produced in Asymptotic Giant Branch (AGB) stars, the 13C({\\alpha},n)16O reaction is the dominant source of neutrons operating during the interpulse period, with the 22Ne+{\\alpha} source affecting mainly the s-process branchings during a thermal pulse. Rate uncertainties in the competing 22Ne({\\alpha},n)25Mg and 22Ne({\\alpha},{\\gamma})26Mg reactions result in large variations of s-process nucleosynthesis. Here, we present up-to-date and statistically rigorous 22Ne+{\\alpha} reaction rates using recent experimental results and Monte Carlo sampling. Our new rates are used in post-processing nucleosynthesis calculations both for massive stars and AGB stars. We demonstrate that the nucleosynthesis uncertainties ...

  2. Laboratory investigations of the alpha-pinene/ozone gas-phase reaction

    Energy Technology Data Exchange (ETDEWEB)

    Benner, C.L.


    In order to provide more insight into terpene photooxidation or ozonolysis reaction mechanisms, a radiotracer technique was developed. This technique was applied to an investigation of the /sup 14/C-alpha-pinene/ozone reaction. In the first phase of the research, the carbon distribution at the conclusion of the ozonolysis reaction was determined by separating carbon-14-labelled gaseous products from labelled aerosols, and counting each phase by liquid scintillation methods. The resulting carbon balance was 38% to 60% filtered aerosols, 6% to 20% gas phase compounds, and 11% to 29% products absorbed on the reaction chamber walls. Recoveries of the alpha-pinene carbon-14 ranging from 79% to 97% were achieved using this method. The alpha-pinene concentrations in these experiments were close to ambient (1 part per billion), yet the carbon balance was similar to that observed at much higher concentrations (>1 part per million). In the second phase of the alpha-pinene study, both gas and aerosol products of the ozonolysis reaction were collected on cartridges impregnated with 2,4-dinitrophenylhydrazine, then analyzed by HPLC. In the final experiments, alpha-pinene aerosol was reacted with a silylating agent to improve the detection of organic acids and alcohols. The gas chromatographic/mass spectrometric analysis of the silylated aerosol products showed evidence of dimer/polymer formation occurring in the ozonolysis reaction.

  3. Estimation of the {alpha} particles and neutron distribution generated during a fusion reaction; Evaluation de la distribution des particules {alpha} et des neutrons issus de la reaction de fusion

    Energy Technology Data Exchange (ETDEWEB)

    Dellacherie, S.


    The respective distributions (or density probabilities) of {alpha} particles and neutrons have been modeled using a Monte-Carlo method for the thermonuclear fusion reaction D + T {yields} {alpha} + n + 17.6 MeV. (N.T.).

  4. Breakout from the hot CNO cycle: the {sup 15}O({alpha},{gamma}) and {sup 18}Ne({alpha},p) reactions

    Energy Technology Data Exchange (ETDEWEB)

    Bradfield-Smith, W.; Laird, A.M.; Davinson, T.; Pietro, A. di; Ostrowski, A.N.; Shotter, A.C.; Woods, P.J. [Dept. of Physics and Astronomy, Univ. of Edinburgh (United Kingdom); Cherubini, S.; Galster, W.; Graulich, J.S.; Leleux, P.; Michel, L.; Ninane, A.; Vervier, J. [Inst. de Physique Nucleaire, UCL, Louvain-la-Neuve (Belgium); Aliotta, M.; Cali, D.; Cappussello, F.; Cunsolo, A.; Spitaleri, C. [INFN, Catania (Italy); Gorres, J.; Wiescher, M. [Notre Dame Univ. (United States); Rahighi, J. [Van de Graaf Lab., Tehran (Iran, Islamic Republic of); Hinnefeld, J. [Indiana Univ., South Bend (United States)


    One of the most important reactions which determines the rate of breakout from the hot CNO cycle is the {sup 15}O({alpha},{gamma}){sup 19}Ne. The reaction {sup 18}Ne({alpha},p){sup 21}Na may also provide an alternative breakout route. Experiments are being undertaken at Louvain-La-Neuve using the radioactive {sup 18}Ne beam to study these reactions by measurement of {alpha}({sup 18}Ne,p){sup 21}Na and d({sup 18}Ne,p){sup 19}Ne{sup *} {yields} {sup 15}O + {alpha} (orig.)

  5. Nuclear reactions induced by high-energy alpha particles (United States)

    Shen, B. S. P.


    Experimental and theoretical studies of nuclear reactions induced by high energy protons and heavier ions are included. Fundamental data needed in the shielding, dosimetry, and radiobiology of high energy particles produced by accelerators were generated, along with data on cosmic ray interaction with matter. The mechanism of high energy nucleon-nucleus reactions is also examined, especially for light target nuclei of mass number comparable to that of biological tissue.

  6. Roles of tumor necrosis factor alpha on sperm acrosin activity and acrosome reaction

    Institute of Scientific and Technical Information of China (English)

    Shu-LingBian; Guo-YiLiu; Hai-XiaWen; Shu-ZhenWang; JiangNi; WeiZhang; HuiSi


    Aim: To study the roles of tumor necrosis factor alpha (TNF-a)on the sperm acrosin activity and acrosome reaction. Methods:The sperm acrosin activity was tested by the method of BAEE/ADH Unity and the acrosome reaction by the Triple-stain technique. Results: TNF-a decreased the sperm acrosin activityand acrosome reaction (P<0.01, P<0.01, respectively);

  7. Proton and alpha evaporation spectra in low energy 12C and 16O induced reactions

    Indian Academy of Sciences (India)

    E T Mirgle; D R Chakrabarty; V M Datar; Suresh Kumar; A Mitra; H H Oza


    Proton and alpha particle spectra have been measured in the 12C+93Nb and 12C+58Ni reactions at E(12C) = 40 and 50 MeV and in the 16O+93Nb reaction at E(16O) = 75 MeV. The spectra are compared with the statistical model calculations. The shapes of the calculated spectra are in agreement with experimental data except for the alpha spectrum in the 12C+93Nb reaction at 40 MeV. The observed evaporation bump is at ∼ 2 MeV lower energy compared to the calculated one. This discrepancy could imply alpha particle emission from a deformed configuration before compound nucleus formation at this near Coulomb barrier beam energy.

  8. Primordial ${\\alpha} + d \\to {}^{6}{\\rm Li} + \\gamma$ reaction and second Lithium puzzle

    CERN Document Server

    Mukhamedzhanov, A M; Bertulani, C A


    During the Big Bang, ${}^{6}{\\rm Li}$ was synthesized via the ${}^{2}{\\rm H}(\\alpha,\\gamma){}^{6}{\\rm Li}$ reaction. After almost 25 years of the failed attempts to measure the ${}^{2}{\\rm H}(\\alpha,\\gamma){}^{6}{\\rm Li}$ reaction in the lab at the Big Bang energies, just recently the LUNA collaboration presented the first successful measurements at two different Big Bang energies [M. Anders {\\it et al.}, Phys. Rev. Lett. {\\bf 113}, 042501 (2014)]. In this paper we will discuss how to improve the accuracy of the direct experiment. To this end the photon's angular distribution is calculated in the potential model. It contains contributions from electric dipole and quadrupole transitions and their interference, which dramatically changes the photon's angular distribution. The calculated distributions at different Big Bang energies have a single peak at $\\sim 50^{\\circ}$. These calculations provide the best kinematic conditions to measure the ${}^{2}{\\rm H}(\\alpha,\\gamma){}^{6}{\\rm Li}$ reaction. The expressions...

  9. $^{24}$Mg($p$, $\\alpha$)$^{21}$Na reaction study for spectroscopy of $^{21}$Na

    CERN Document Server

    Cha, S M; Kim, A; Lee, E J; Ahn, S; Bardayan, D W; Chipps, K A; Cizewski, J A; Howard, M E; Manning, B; O'Malley, P D; Ratkiewicz, A; Strauss, S; Kozub, R L; Matos, M; Pain, S D; Pittman, S T; Smith, M S; Peters, W A


    The $^{24}$Mg($p$, $\\alpha$)$^{21}$Na reaction was measured at the Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory in order to better constrain spins and parities of energy levels in $^{21}$Na for the astrophysically important $^{17}$F($\\alpha, p$)$^{20}$Ne reaction rate calculation. 31 MeV proton beams from the 25-MV tandem accelerator and enriched $^{24}$Mg solid targets were used. Recoiling $^{4}$He particles from the $^{24}$Mg($p$, $\\alpha$)$^{21}$Na reaction were detected by a highly segmented silicon detector array which measured the yields of $^{4}$He particles over a range of angles simultaneously. A new level at 6661 $\\pm$ 5 keV was observed in the present work. The extracted angular distributions for the first four levels of $^{21}$Na and Distorted Wave Born Approximation (DWBA) calculations were compared to verify and extract angular momentum transfer.

  10. Cross section measurement for (n,n{alpha}) reactions by 14 MeV neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Kasugai, Y.; Ikeda, Y.; Uno, Y. [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment; Yamamoto, H.; Kawade, K.


    Nine (n,n{alpha}) cross sections for (n,n{alpha}) reactions induced by 13.5-14.9 MeV neutrons were measured for {sup 51}V, {sup 65}Cu, {sup 71}Ga, {sup 76}Ge, {sup 87}Rb, {sup 91}Zr, {sup 93}Nb, {sup 96}Zr and {sup 109}Ag isotopes by using Fusion Neutronics Source (FNS) at JAERI. The reactions for 91Zr and 96Zr were measured for the first time. The evaluated data of JENDL-3 and ENDF/B-VI were compared with the present data. Some of the evaluated values are much different from our data by a factor more than ten. (author)

  11. Low-energy photodisintegration of {sup 9}Be and {alpha}+{alpha}+n<->{sup 9}Be+{gamma} reactions at astrophysical conditions

    Energy Technology Data Exchange (ETDEWEB)

    Efros, V.D. [Rossijskij Nauchnyj Tsentr ``Kurchatovskij Inst.``, Moscow (Russian Federation); Oberhummer, H. [Institut fuer Kernphysik, Wiedner Hauptstrasse 8--10, TU Wien, A--1040, Vienna (Austria); Pushkin, A. [Department of Mathematical Physics, Lund Institute of Technology, P.O. Box, 118 S--221 00 Lund (Sweden); Thompson, I.J. [Department of Physics, University of Surrey, Guildford GU2 5XH (United Kingdom)


    A semi-microscopic model for the low-energy photodisintegration of the {sup 9}Be nucleus is constructed, and the experimental data are analyzed with its help. The older radioactive isotope data are supported by this analysis. The theoretical photodisintegration cross section is derived. The astrophysical rates for the reaction {alpha}+{alpha}+n{yields}{sup 9}Be +{gamma} and the reverse photodisintegration of {sup 9}Be are calculated. The new reaction rate for {alpha}+{alpha}+n{yields}{sup 9}Be +{gamma} is compared with previous estimations. (orig.) With 3 figs., 1 tab., 30 refs.

  12. Three-body calculation of triple-alpha reaction at low energies (United States)

    Ishikawa, Souichi


    The reaction rate of the triple-alpha (3α) process at low temperatures, where resonant reaction is not dominant, is calculated through the inverse process, the photodisintegration of a 12C nucleus. For this, Schrödinger equations in a three-alpha (3-α) model of 12C are directly solved by a Faddeev method, which has been successfully applied to three-nucleon problem so far. The nuclear Hamiltonian consists of an α-α potential, which reproduces the 8Be resonance state, together with three-body potentials to reproduce 12C properties. Our results of the 3α reaction rate are about 103 times larger at low temperature (T = 107 K) than a standard rate from the Nuclear Astrophysics Compilation of Reaction Rates (NACRE), which means our results are remarkably smaller than recent results of quantum-mechanical three-body calculations by Ogata et al.

  13. Inelastic Branch of the Stellar Reaction $^{14}$O$(\\alpha,p)^{17}$F

    CERN Multimedia

    Hass, M; Van duppen, P L E


    We propose to use the upgraded REX-ISOLDE beam energy to study the astrophysically important $^{14}$O($\\alpha$, p)$^{17}$F reaction in time reverse kinematics. In particular, we will use the highly efficient miniball + CD detection system to measure the previously undetermined inelastic proton branch of the 1$^-$ state at 6.15 MeV in $^{18}$Ne. This state dominates the reaction rate under X-ray burster conditions.

  14. Studies on alpha-induced astrophysical reactions using the low-energy RI beam separator CRIB

    Directory of Open Access Journals (Sweden)

    Yamaguchi H.


    Full Text Available Several alpha-induced astrophysical reactions have been studied at CRIB (CNS Radioactive Ion Beam separator, which is a low-energy RI beam separator at Center for Nuclear Study (CNS of the University of Tokyo. Two major methods to study them are the α resonant scattering, and direct measurements of (α,p reactions using an active or inactive helium gas target. Among the recent studies at CRIB, the measurement of 7Be+α resonant scattering is discussed.

  15. Synthesis of pyrroles by consecutive multicomponent reaction/[4 + 1] cycloaddition of alpha-iminonitriles with isocyanides. (United States)

    Fontaine, Patrice; Masson, Géraldine; Zhu, Jieping


    [4 + 1] Cycloaddition of alpha,beta-unsaturated imidoyl cyanide (2-cyano-1-azadienes) with isocyanides in the presence of a catalytic amount of AlCl(3) afforded polysubstituted 2-amino-5-cyanopyrroles in good to excellent yields. In combination with the IBX/TBAB-mediated oxidative Strecker reaction, this important heterocycle is readily synthesized in two steps from simple starting materials.

  16. Test of statistical model cross section calculations for $\\alpha$-induced reactions on $^{107}$Ag at energies of astrophysical interest

    CERN Document Server

    Yalcin, C; Rauscher, T; Kiss, G G; Özkan, N; Güray, R T; Halász, Z; Szücs, T; Fülöp, Zs; Korkulu, Z; Somorjai, E


    Astrophysical reaction rates, which are mostly derived from theoretical cross sections, are necessary input to nuclear reaction network simulations for studying the origin of $p$ nuclei. Past experiments have found a considerable difference between theoretical and experimental cross sections in some cases, especially for ($\\alpha$,$\\gamma$) reactions at low energy. Therefore, it is important to experimentally test theoretical cross section predictions at low, astrophysically relevant energies. The aim is to measure reaction cross sections of $^{107}$Ag($\\alpha$,$\\gamma$)$^{111}$In and $^{107}$Ag($\\alpha$,n)$^{110}$In at low energies in order to extend the experimental database for astrophysical reactions involving $\\alpha$ particles towards lower mass numbers. Reaction rate predictions are very sensitive to the optical model parameters and this introduces a large uncertainty into theoretical rates involving $\\alpha$ particles at low energy. We have also used Hauser-Feshbach statistical model calculations to s...

  17. Investigating the alpha-clustering on the surface of $^{120}$Sn via ($p$,$p\\alpha$) reaction and the validity of the factorization approximation

    CERN Document Server

    Yoshida, Kazuki; Ogata, Kazuyuki


    The $^{120}$Sn($p$,$p\\alpha$)$^{116}$Cd reaction at 392 MeV is investigated with the distorted wave impulse approximation (DWIA) framework. We show that this reaction is very peripheral mainly because of the strong absorption of $\\alpha$ by the reaction residue $^{116}$Cd, and the $\\alpha$-clustering on the nuclear surface can be probed clearly. We investigate also the validity of the so-called factorization approximation that has frequently been used so far. It is shown that the kinematics of $\\alpha$ in the nuclear interior region is significantly affected by the distortion of $^{116}$Cd, but it has no effect on the reaction observables because of the strong absorption in that region.

  18. Evaluation of the nuclear data on ({alpha}, n) reaction for F, Na, Al, Cr, Fe, Ni, and Cu

    Energy Technology Data Exchange (ETDEWEB)

    Matsunobu, Hiroyuki [Data Engineering, Inc., Fujisawa, Kanagawa (Japan); Yamamuro, Nobuhiro


    Evaluation of the nuclear data on ({alpha}, n) reaction, which are very important in analyzing radiation shielding and criticality safety relating to storage, transport, and handling of spent fuel was carried out for 18 nuclides, and the results were compared with the experimental data for ({alpha}, n) reaction cross section and thick target neutron yield. (author)

  19. \\alpha-clustering effects in dissipative 12C+12C reactions at 95 MeV

    CERN Document Server

    Baiocco, G; Gulminelli, F; D'Agostino, M; Bruno, M; Abbondanno, U; Barlini, S; Bini, M; Carboni, S; Casini, G; Cinausero, M; Gramegna, M Degerlier F; Kravchuk, V L; Marchi, T; Olmi, A; Pasquali, G; Piantelli, S; Raduta, Ad R


    Dissipative 12C+12C reactions at 95 MeV are fully detected in charge with the GARFIELD and RCo apparatuses at LNL. A comparison to a dedicated Hauser-Feshbach calculation allows to select events which correspond, to a large extent, to the statistical evaporation of highly excited 24Mg, as well as to extract information on the isotopic distribution of the evaporation residues in coincidence with their complete evaporation chain. Residual deviations from a statistical behaviour are observed in \\alpha yields and attributed to the persistence of cluster correlations well above the 24Mg threshold for 6 \\alpha's decay.

  20. Theoretical reaction rates of the $^{12}$C($\\alpha$,$\\gamma$)$^{16}$O reaction from the potential model

    CERN Document Server

    Katsuma, M


    The radiative capture cross sections of $^{12}$C($\\alpha$,$\\gamma$)$^{16}$O and derived reaction rates are calculated from the direct capture potential model. The resulting $S$-factor at low energies is found to be dominated by $E$2 transition to the $^{16}$O ground state. The $E$1 and $E$2 $S$-factors at $E_{c.m.}=0.3$ MeV are $S_{E1}\\approx3$ keV~b and $S_{E2}=150^{+41}_{-17}$ keV~b, respectively. The sum of the cascade transition through the excited state of $^{16}$O is $S_{\\rm casc}= 18\\pm4.5$ keV~b. The derived reaction rates at low temperatures seem to be concordant with those from the previous evaluation. For astrophysical applications, our reaction rates below $T_9=3$ are provided in an analytic expression.

  1. Trojan Horse method and radioactive ion beams: study of $^{18}$F(p,$\\alpha$)$^{15}$O reaction at astrophysical energies

    CERN Document Server

    Gulino, M; Rapisarda, G G; Kubono, S; Lamia, L; La Cognata, M; Yamaguchi, H; Hayakawa, S; Wakabayashi, Y; Iwasa, N; Kato, S; Komatsubara, H; Teranishi, T; Coc, A; De Séréville, N; Hammache, F; Spitaleri, C


    The Trojan Horse Method was applied for the first time to a Radioactive Ion Beam induced reaction to study the reaction $^{18}$F(p,$\\alpha$)$^{15}$O via the three body reaction $^{18}$F(d,$\\alpha$ $^{15}$O)n at the low energies relevant for astrophysics. The abundance of $^{18}$F in Nova explosions is an important issue for the understanding of this astrophysical phenomenon. For this reason it is necessary to study the nuclear reactions that produce or destroy $^{18}$F in Novae. $^{18}$F(p,$\\alpha$)$^{15}$O is one of the main $^{18}$F destruction channels. Preliminary results are presented in this paper.

  2. Role of ($\\alpha$,n) reactions under $r$-process conditions in neutrino-driven winds revisited

    CERN Document Server

    Mohr, Peter


    Background: The astrophysical $r$-process occurs in an explosive astrophysical event under extremely neutron-rich conditions, leading to (n,$\\gamma$)-($\\gamma$,n) equilibrium along isotopic chains which peaks around neutron separation energies of a few MeV. Nuclei with larger $Z$ are usually produced by $\\beta^-$-decay, but under certain conditions also $\\alpha$-induced reactions may become relevant for the production of nuclei with $Z+2$. Purpose: The uncertainties of the reaction rates of these $\\alpha$-induced reactions are discussed within the statistical model. As an example, $\\alpha$-induced ($\\alpha$,n) and $(\\alpha$,$x$n) reaction cross sections for the neutron-rich $^{86}$Se nucleus are studied in detail. Method: In a first step, the relevance of ($\\alpha$,n) and $(\\alpha$,$x$n) reactions is analyzed. Next the uncertainties are determined from a variation of the $\\alpha$-nucleus potential which is the all-dominant parameter for the astrophysical $Z \\rightarrow Z+2$ reaction rate. Results: It is found...

  3. Investigation of the triple-alpha reaction in a full three-body approach (United States)

    Nguyen, Ngoc Bich

    We have developed a new three-body method to compute the triple-alpha reaction rate at low temperatures where measurements are impossible and many numerical attempts have failed before. In this work, the triple-alpha is modeled as a three-body Borromean system in hyperspherical harmonics coordinates. In the low temperature region, the triple-alpha proceeds through a quadrupole transition from the 0+ continuum to the 2+1 bound state in 12C. The 2+1 bound state is obtained by solving a set of coupled channels equations in hyper-radius coordinates for negative energy with a boundary condition that requires the wavefunction to go to zero at large distances. The same approach can not be applied to the 0+ continuum state because it requires an exact boundary condition for the three charged particles. We therefore combine the R-matrix expansion, the R-matrix propagation method, and the screening technique in the hyperspherical harmonics basis to obtain a numerically stable three-body continuum wavefunction for the alpha + alpha + alpha system. We employ the Ali-Bodmer potential for the alpha-alpha interaction which reproduces the low energy phase shifts as well as the 0+ resonance of 8Be. We add a three-body force to fit experimental data. Both the 2+1 bound state and the 0+2 resonant state in 12C are well reproduced in our framework. We find a dominant triangle three-alpha configuration for the Hoyle resonance by studying the density distribution function. The resonant and non-resonant continuum states of 12C(0+) are obtained simultaneously, allowing us to include these two processes on the same footing. Long range Coulomb interactions show important effects especially in the low temperature regime. We also present a detailed convergence study of the triple-alpha reaction rate with respect to the screening radius and the size of the model space. The new rate agrees with the NACRE rate for temperatures greater than 0.07 GK, but a large enhancement at lower temperatures is

  4. OH-initiated oxidation of monoterpenes: reaction of alpha-pinene. (United States)

    Librando, Vito; Tomaselli, Gaetano; Tringali, Giuseppe


    The aim of this paper is to study the reaction products of alpha-pinene, beta-pinene, limonene, 3-carene and sabinene with OH radicals by FT-IR spectroscopy and by HPLC-MS-MS, to evaluate the secondary aerosol formation. All gas phase reaction products were quantified using reference compounds. As source of OH radicals were used H2O2 and CH3ONO. The experiments were performed at low terpene concentration (0.9-2.1 ppm) and at high terpene concentration (4.1-13.2 ppm), using H2O2 and CH3ONO as sources of OH radicals.

  5. Helium Ignition on Accreting Neutron Stars with a New Triple-alpha Reaction Rate

    CERN Document Server

    Peng, Fang


    We investigate the effect of a new triple-alpha reaction rate from Ogata et al. (2009) on helium ignition conditions on accreting neutron stars and on the properties of the subsequent type I X-ray burst. We find that the new rate leads to significantly lower ignition column density for accreting neutron stars at low accretion rates. We compare the results of our ignition models for a pure helium accretor to observations of bursts in ultra-compact X-ray binary (UCXBs), which are believed to have nearly pure helium donors. For mdot > 0.001 mdot_Edd, the new triple-alpha reaction rate from Ogata et al. (2009) predicts a maximum helium ignition column of ~ 3 x 10^9 g cm^{-2}, corresponding to a burst energy of ~ 4 x 10^{40} ergs. For mdot ~ 0.01 mdot_Edd at which intermediate long bursts occur, the predicted burst energies are at least a factor of 10 too low to explain the observed energies of such bursts in UCXBs. This finding adds to the doubts cast on the triple-alpha reaction rate of Ogata et al. (2009) by th...

  6. Determination by transfer reaction of alpha widths in fluorine for astrophysical interest; Determination par reaction de transfert de largeurs alpha dans le fluor 19. Applications a l'astrophysique

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira Santos, F. de


    The nucleosynthesis of fluorine is not known. Several astrophysical models predict the alpha radiative capture onto N{sup 15} as the main fluorine production reaction. In the expression of the reaction rate, one parameter is missing: the alpha width of the resonance on the E = 4.377 MeV level in fluorine. A direct measurement is excluded due to the very low cross-section expected. We have determined this alpha width using a transfer reaction followed by analyses with FR-DWBA (Finite Range Distorted Wave Born Approximation) in a simple cluster alpha model. This experiment was carried out with a Li{sup 7} beam with E = 28 MeV onto a N{sup 15} gas target. The 16 first levels were studied. Spectroscopic factors were extracted for most of them. Alpha widths for unbound levels were determined. Many alpha width were compared with known values from direct reaction and the differences lie within the uncertainty range (factor 2). The alpha width for the E = 4.377 MeV level was determined ({gamma}{sub {alpha}} = 1.5*10{sup -15} MeV), its value is about 60 times weaker than the used value. The influence of our new rate was studied in AGB (Asymptotic Giant Branch) stars during thermal pulses. In this model the alteration is sensitive. (author)

  7. Comment on "15O(alpha,gamma)19Ne Breakout Reaction and Impact on X-Ray Bursts"

    CERN Document Server

    Davids, B


    A recently published letter reports a measurement of alpha decay from states in 19Ne at excitation energies below 4.5 MeV. The measured alpha decay branching ratios B_alpha are used to calculate the astrophysical rate of the 15O(alpha,gamma)19Ne reaction and to draw conclusions regarding the transition between steady state and unstable nuclear burning on accreting neutron stars. Here I show that the calculated astrophysical reaction rate is based on an unreliable value of B_alpha for the 4.03 MeV state and point out a serious internal inconsistency in the letter's treatment of low statistics alpha decay measurements.

  8. Ethanol oxidation: kinetics of the alpha-hydroxyethyl radical + O2 reaction. (United States)

    da Silva, Gabriel; Bozzelli, Joseph W; Liang, Long; Farrell, John T


    Bioethanol is currently a significant gasoline additive and the major blend component of flex-fuel formulations. Ethanol is a high-octane fuel component, and vehicles designed to take advantage of higher octane fuel blends could operate at higher compression ratios than traditional gasoline engines, leading to improved performance and tank-to-wheel efficiency. There are significant uncertainties, however, regarding the mechanism for ethanol autoignition, especially at lower temperatures such as in the negative temperature coefficient (NTC) regime. We have studied an important chemical process in the autoignition and oxidation of ethanol, reaction of the alpha-hydroxyethyl radical with O2(3P), using first principles computational chemistry, variational transition state theory, and Rice-Ramsperger-Kassel-Marcus (RRKM)/master equation simulations. The alpha-hydroxyethyl + O2 association reaction is found to produce an activated alpha-hydroxy-ethylperoxy adduct with ca. 37 kcal mol(-1) of excess vibrational energy. This activated adduct predominantly proceeds to acetaldehyde + HO(2), with smaller quantities of the enol vinyl alcohol (ethenol), particularly at higher temperatures. The reaction to acetaldehyde + HO2 proceeds with such a low barrier that collision stabilization of C2O3H5 isomers is unimportant, even for high-pressure/low-temperature conditions. The short lifetimes of these radicals precludes the chain-branching addition of a second O2 molecule, responsible for NTC behavior in alkane autoignition. This result helps to explain why ignition delays for ethanol are longer than those for ethane, despite ethanol having a weaker C-C bond energy. Given its relative instability, it is also unlikely that the alpha-hydroxy-ethylperoxy radical acts as a major acetaldehyde sink in the atmosphere, as has been suggested.

  9. Experimental investigation of the reactions {sup 25}Mg({alpha},n){sup 28}Si, {sup 26}Mg({alpha},n){sup 29}Si, {sup 18}O({alpha},n){sup 21}Ne and their impact on stellar nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Falahat, Sascha


    In the present dissertation, the nuclear reactions {sup 25}Mg({alpha},n){sup 28}Si, {sup 26}Mg({alpha},n){sup 29}Si, {sup 18}O({alpha},n){sup 21}Ne are investigated in the astrophysically interesting energy region from E{sub {alpha}}=1000 keV to E{sub {alpha}}=2450 keV. The experiments were performed at the Nuclear Structure Laboratory of the University of Notre Dame (USA) with the Van-de-Graaff accelerator KN. Solid state targets with evaporated magnesium or anodized oxygen were bombarded with {alpha}-particles and the released neutrons detected. For the detection of the released neutrons, computational simulations were used to construct a neutron detector based on {sup 3}He counters. Because of the strong occurrence of background reactions, different methods of data analysis were employed. Finally, the impact of the reactions {sup 25}Mg({alpha},n){sup 28}Si, {sup 26}Mg({alpha},n){sup 29}Si, {sup 18}O({alpha},n){sup 21}Ne on stellar nucleosynthesis is investigated by means of network calculations. (orig.)

  10. Semiconductor effect on the selective photocatalytic reaction of. alpha. -hydroxycarboxylic acids

    Energy Technology Data Exchange (ETDEWEB)

    Harada, H.; Ueda, T. (Meisei Univ., Tokyo (Japan)); Sakata, T. (Institute for Molecular Science, Okazaki (Japan))


    Photocatalytic and photoelectrochemical reactions of {alpha}-hydroxycarboxylic acids were compared for various types of semiconductor electrode (TiO{sub 2}, CdS, SrTiO{sub 3}, and ZnO) and suspension of particulate semiconductor (TiO{sub 2}, CdS, MoS{sub 2}, and ZnS). These reactions were found to depend strongly on the type of semiconductor studied. In the cases of Pt/CdS and ZnS photocatalysts, the hydroxy group of the acids was oxidized selectively into the corresponding keto acids, whereas in the cases of Pt/TiO{sub 2}, decarboxylation took place in addition to dehydrogenation. The same dependence was observed in the photoelectrochemical reactions with semiconductor single-crystal electrodes. For the TiO{sub 2} electrode, the reaction depends strongly on pH, whereas it does not for CdS. The results of pH effects, electrochemical reaction with various metal electrodes, and Fenton reaction in a homogeneous solution suggest the importance of adsorption of the reactants on the semiconductor and metal surfaces for the selective reaction.

  11. Resonance analysis of the {sup 12}C,{sup 13}C({alpha},n) reactions and evaluation of neutron yield data of the reaction

    Energy Technology Data Exchange (ETDEWEB)

    Murata, Toru [AITEL Corp., Tokyo (Japan)


    The {sup 12}C({alpha},n){sup 15}O reaction and the {sup 13}C({alpha},n){sup 16}O reaction were analyzed with a resonance formula in the incident {alpha}-particle energy range of 1.0 to 16.0 MeV. With the obtained resonance parameters, branching ratios of the emitted neutrons to the several levels of the residual nucleus and their angular distributions were calculated to obtain the energy spectrum of emitted neutrons. Thick target neutron yield of carbon were also calculated and compared with the experimental data. (author)

  12. Effects of a New Triple-{\\alpha} Reaction on the S-process in Massive Stars

    CERN Document Server

    Kikuchi, Yukihiro; Matsuo, Yasuhide; Hashimoto, Masa-aki; Fujimoto, Shin-ichiro


    Effects of a new triple-{\\alpha} reaction rate on the s-process during the evolution of a massive star of 25 M\\odot are investigated for the first time. Although the s-process in massive stars has been believed to be established with only minor change, we find that the s-process with use of the new rate during the core He-burning is very inefficient compared to the case with the previous triple-{\\alpha} rate. However, the difference of the overproduction is found to be largely compensated by the subsequent C-burning. Since the s-process in massive stars has been attributed so far to the neutron irradiation during core He-burning, our finding reveals the importance of C-burning for the s-process during the evolution of massive stars.

  13. Excited states of {sup 117}Sb populated in the reaction ({alpha}, 2n{gamma})

    Energy Technology Data Exchange (ETDEWEB)

    Lobach, Y.N.; Trishin, V.V. [Institute of Nuclear Research, Kiev (Ukraine)


    The structure of {sup 117}Sb levels populated in the reaction {sup 115}In({alpha}, 2n{gamma}) at E{sub {alpha}} = 27.2 MeV is investigated. Data on {gamma}{gamma} coincidences and the angular distributions of {gamma} rays are used to construct the energy-level diagram and to determine the multipole orders of various transitions and the quantum numbers of levels. The positive-parity band based on the 9/2{sup +} level is observed up to I = 23/2. A new band is revealed that is probably based on one of the isomer states. The levels of {sup 117}Sb are interpreted in terms of the coupling of a proton to vibrations of the core or to three-quasiparticle excitations. Identical bands in the neighboring isotopes of Sb are discussed. 26 refs., 7 figs., 3 tabs.

  14. Experimental study of the astrophysical gamma-process reaction 124Xe(alpha,gamma)128Ba

    CERN Document Server

    Halász, Z; Gyürky, Gy; Elekes, Z; Fülöp, Zs; Szücs, T; Kiss, G G; Szegedi, N; Rauscher, T; Görres, J; Wiescher, M


    The synthesis of heavy, proton rich isotopes in the astrophysical gamma-process proceeds through photodisintegration reactions. For the improved understanding of the process, the rates of the involved nuclear reactions must be known. The reaction 128Ba(g,a)124Xe was found to affect the abundance of the p nucleus 124Xe. Since the stellar rate for this reaction cannot be determined by a measurement directly, the aim of the present work was to measure the cross section of the inverse 124Xe(a,g)128Ba reaction and to compare the results with statistical model predictions. Of great importance is the fact that data below the (a,n) threshold was obtained. Studying simultaneously the 124Xe(a,n)127Ba reaction channel at higher energy allowed to further identify the source of a discrepancy between data and prediction. The 124Xe + alpha cross sections were measured with the activation method using a thin window 124Xe gas cell. The studied energy range was between E = 11 and 15 MeV close above the astrophysically relevant...

  15. Effects of Triple-$\\alpha$ and $^{12}\\rm C(\\alpha,\\gamma)^{16}O$ Reaction Rates on the Supernova Nucleosynthesis in a Massive Star of 25 $M_{\\odot}$

    CERN Document Server

    Kikuchi, Yukihiro; Ono, Masaomi; Fukuda, Ryohei


    We investigate effects of triple-$\\alpha$ and $^{12}\\rm C(\\alpha,\\gamma) ^{16}O$ reaction rates on the production of supernova yields for a massive star of 25 $M_{\\odot}$ whose helium core is considered to be around a 8 $M_{\\odot}$. We combine the reaction rates to see the rate dependence, where the rates are considered to cover the possible variation of the rates. We adopt four combinations of the reaction rates from the two triple-$\\alpha$ reaction rates and two $^{12}\\rm C(\\alpha,\\gamma)^{16}O$ ones. We compare the calculated abundance ratios with the solar system abundances and deduce some constraints to the reaction rates. As the results, the conventional rate is adequate for the triple-$\\alpha$ reaction rate and rather higher value of the reaction rate is favorable for the $^{12}\\rm C(\\alpha,\\gamma)^{16}O$ rate.

  16. Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate. (United States)

    Long, Alexandra J; Clifton, Ian J; Roach, Peter L; Baldwin, Jack E; Schofield, Christopher J; Rutledge, Peter J


    Isopenicillin N synthase (IPNS) is a non-haem iron(II) oxidase which catalyses the biosynthesis of isopenicillin N from the tripeptide delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV). Herein we report crystallographic studies to investigate the reaction of IPNS with the truncated substrate analogue delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate (ACAb). It has been reported previously that this analogue gives rise to three beta-lactam products when incubated with IPNS: two methyl penams and a cepham. Crystal structures of the IPNS-Fe(II)-ACAb and IPNS-Fe(II)-ACAb-NO complexes have now been solved and are reported herein. These structures and modelling studies based on them shed light on the diminished product selectivity shown by IPNS in its reaction with ACAb and further rationalize the presence of certain key residues at the IPNS active site.

  17. Testing an ionization chamber with gaseous samples and measurements of the (n, alpha) reaction cross sections

    CERN Document Server

    Gledenov, Yu M; Salatskii, V I; Sedyshev, P V; Andrzejewski, J; Szalanski, P


    A new ionization chamber with gaseous samples (GIC) has been designed and tested on the thermal and resonance neutron beams of FLNP's neutron sources. The exposed gas volume serves as a target for neutrons. The obtained thermal cross sections for the sup 1 sup 7 O(n, alpha) sup 1 sup 4 C, sup 2 sup 1 Ne(n, alpha) sup 1 sup 8 O and sup 3 sup 6 Ar(n, alpha) sup 3 sup 3 S reactions are (233+-12) mb, (0.18+-0.09) mb and (5.43+-0.27) mb, respectively. These measurements have been performed on a pure beam of thermal neutrons from the high flux reactor IBR-2; and they demonstrated high efficiency and reliability of the method. Compared to samples on substrates, the application of gaseous samples makes the beam background essentially lower, and what is more important, the background component is totally absent due to the absence of Li and B microimpurities in gaseous samples while they do present in the samples on substrates. The method is also applicable to measurements with resonance neutrons. The recovery capabili...

  18. (p,. cap alpha. ) reaction on /sup 98/Mo and /sup 100/Mo. [12. 3 and 15 Mev, angular distributions

    Energy Technology Data Exchange (ETDEWEB)

    Avrigeanu, V.; Bucurescu, D.; Constantinescu, G.; Ivascu, M.; Popescu, D.; Teodorescu, R.


    Levels of /sup 95/Nb and /sup 97/Nb were studied with the /sup 98/Mo(p, ..cap alpha..) reaction at 12.3 MeV and the /sup 100/Mo(p, ..cap alpha..) reaction at 15 MeV incident energy, respectively. Angular distributions were determined for the most prominent levels below 2 MeV, and compared with DWBA calculations based on a triton-cluster form factor. The results are compared with level schemes provided by other nuclear reactions. (auth)

  19. Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

    Energy Technology Data Exchange (ETDEWEB)

    Qaim, Syed M.; Spahn, Ingo; Scholten, Bernhard; Neumaier, Bernd [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Neurowissenschaften und Medizin (INM), Nuklearchemie (INM-5)


    Alpha particles exhibit three important characteristics: scattering, ionisation and activation. This article briefly discusses those properties and outlines their major applications. Among others, α-particles are used in elemental analysis, investigation and improvement of materials properties, nuclear reaction studies and medical radionuclide production. The latter two topics, dealing with activation of target materials, are treated in some detail in this paper. Measurements of excitation functions of α-particle induced reactions shed some light on their reaction mechanisms, and studies of isomeric cross sections reveal the probability of population of high-spin nuclear levels. Regarding medical radionuclides, an overview is presented of the isotopes commonly produced using α-particle beams. Consideration is also given to some routes which could be potentially useful for production of a few other radionuclides. The significance of α-particle induced reactions to produce a few high-spin isomeric states, decaying by emission of low-energy conversion or Auger electrons, which are of interest in localized internal radiotherapy, is outlined. The α-particle beam, thus broadens the scope of nuclear chemistry research related to development of non-standard positron emitters and therapeutic radionuclides.

  20. Test of statistical model cross section calculations for $\\alpha$-induced reactions on $^{107}$Ag at energies of astrophysical interest


    C. Yalcin; Gyürky, Gy.; Rauscher, T.; Kiss, G G; Özkan, N.; Güray, R T; Z. Halász; Szücs, T.; Fülöp, Zs.; Z. Korkulu; Somorjai, E.


    Astrophysical reaction rates, which are mostly derived from theoretical cross sections, are necessary input to nuclear reaction network simulations for studying the origin of $p$ nuclei. Past experiments have found a considerable difference between theoretical and experimental cross sections in some cases, especially for ($\\alpha$,$\\gamma$) reactions at low energy. Therefore, it is important to experimentally test theoretical cross section predictions at low, astrophysically relevant energies...

  1. Reaction of glycolaldehyde with proteins: latent crosslinking potential of alpha-hydroxyaldehydes. (United States)

    Acharya, A S; Manning, J M


    The Schiff base adducts of glyceraldehyde with hemoglobin undergo Amadori rearrangement to form stable ketoamine structures; this reaction is similar to the nonenzymic glucosylation of proteins. In the present studies the analogous rearrangement of the Schiff base adducts of glycolaldehyde with proteins has been demonstrated. However, the Amadori rearrangement of the Schiff base adduct produces a new aldehyde function, an aldoamine, which is generated in situ and is capable of forming Schiff base linkages with another amino group, leading to covalent crosslinking of proteins. Sodium dodecyl sulfate gel electrophoresis of the glycoaldehyde-RNase A adduct showed the presence of dimers, trimers, and tetramers of RNase A, demonstrating the crosslinking potential of this alpha-hydroxyaldehyde. The crosslinked products exhibited an absorption band with a maximum around 325 nm and fluorescence around 400 nm when excited at 325 nm. The crosslinking reaction, the formation of a 325-nm absorption band, and the development of fluorescence were prevented when the incubation was carried out in the presence of sodium cyanoborohydride. This finding indicates that the Amadori rearrangement that generates a new carbonyl function is a crucial step in this covalent crosslinking. Glycolaldehyde could be a bifunctional reagent of unique utility because its crosslinking potential is latent, expressed only upon completion of the primary reaction.

  2. A new study of $^{10}$B(p,$\\alpha$)$^{7}$Be reaction at low energies

    CERN Document Server

    Caciolli, A; Broggini, C; La Cognata, M; Lamia, L; Menegazzo, R; Mou, L; Puglia, S M R; Rigato, V; Romano, S; Alvarez, C Rossi; Sergi, M L; Spitaleri, C; Tumino, A


    The $^{10}$B(p,$\\alpha$)$^{7}$Be reaction is of great interest since it has many applications in different fields of research such as nuclear astrophysics, nuclear physics, and models of new reactors for clean energy generation. This reaction has been studied at the AN2000 accelerator of the INFN National Laboratories of Legnaro (LNL). The total cross section has been measured in a wide energy range (250 $-$ 1182 keV) by using the activation method. The decays of the $^7$Be nuclei produced by the reaction were measured at the low counting facility of LNL by using two fully shielded high-purity germanium detectors. The present dataset shows a large discrepancy with respect to one of the previous data at the same energies and reduces the total uncertainty to the level of 6\\%. An R-matrix calculation has been performed on the present data using the parameters from previous Trojan Horse measurements for the 10 and 500 keV resonances. The present data do not lay on the R-matrix fit in one point suggesting the exis...

  3. Quantitative and selective polymerase chain reaction analysis of highly similar human alpha-class glutathione transferases. (United States)

    Larsson, Emilia; Mannervik, Bengt; Raffalli-Mathieu, Françoise


    Alpha-class glutathione transferases (GSTs) found expressed in human tissues constitute a family of four homologous enzymes with contrasting enzyme activities. In particular, GST A3-3 has been shown to contribute to the biosynthesis of steroid hormones in human cells and is selectively expressed in steroidogenic tissues. The more ubiquitous GST A1-1, GST A2-2, and GST A4-4 appear to be primarily involved in detoxification processes and are expressed at higher levels than GST A3-3. We are interested in studying the cell and tissue expression of the GST A3-3 gene, yet the existence of highly expressed sequence-similar homologs and of several splice variants is a serious challenge for the specific detection of unique transcript species. We found that published polymerase chain reaction (PCR) primers for GST A3-3 lack the specificity required for reliable quantitative analysis. Therefore, we designed quantitative PCR (qPCR) primers with greatly increased discrimination power for the human GSTA3 full-length transcript. The improved primers allow accurate discrimination between GST A3-3 and the other alpha-class GSTs and so are of great value to studies of the expression of the GSTA3 gene. The novel primers were used to quantify GSTA3 transcripts in human embryonic liver and steroidogenic cell lines.

  4. Measurement and evaluation of the excitation functions for alpha particle induced nuclear reactions on niobium

    CERN Document Server

    Tarkanyi, F; Szelecsenyi, F; Sonck, M; Hermanne, A


    Alpha particle induced nuclear reactions were investigated with the stacked foil activation technique on natural niobium targets up to 43 MeV. Excitation functions were measured for the production of sup 9 sup 6 sup m sup g Tc, sup 9 sup 5 sup m Tc, sup 9 sup 5 sup g Tc, sup 9 sup 4 sup g Tc, sup 9 sup 5 sup m sup g Nb and sup 9 sup 2 sup m Nb. Cumulative cross-sections, thick target yields and activation functions were deduced and compared with available literature data. Applications of the excitation functions in the field of thin layer activation techniques and beam monitoring are also discussed.

  5. Reactions of the alkoxy radicals formed following OH-addition to alpha-pinene and beta-pinene. C-C bond scission reactions. (United States)

    Dibble, T S


    The atmospheric degradation pathways of the atmospherically important terpenes alpha-pinene and beta-pinene are studied using density functional theory. We employ the correlation functional of Lee, Yang, and Parr and the three-parameter HF exchange functional of Becke (B3LYP) together with the 6-31G(d) basis set. The C-C bond scission reactions of the beta-hydroxyalkoxy radicals that are formed after OH addition to alpha-pinene and beta-pinene are investigated. Both of the alkoxy radicals formed from the alpha-pinene-OH adduct possess a single favored C-C scission pathway with an extremely low barrier (approximately 3 kcal/mol) leading to the formation of pinonaldehyde. Neither of these pathways produces formaldehyde, and preliminary computational results offer some support for suggestions that 1,5 or 1,6 H-shift (isomerization) reactions of alkoxy radicals contribute to formaldehyde production. In the case of the alkoxy radical formed following OH addition to the methylene group of beta-pinene, there exists two C-C scission reactions with nearly identical barrier heights (approximately 7.5 kcal/mol); one leads to known products (nopinone and formaldehyde) but the ultimate products of the competing reaction are unknown. The single C-C scission pathway of the other alkoxy radical from beta-pinene possesses a very low (approximately 4 kcal/mol) barrier. The kinetically favored C-C scission reactions of all four alkoxy radicals appear to be far faster than expected rates of reaction with O2. The rearrangement of the alpha-pinene-OH adduct, a key step in the proposed mechanism of formation of acetone from alpha-pinene, is determined to possess a barrier of 11.6 kcal/mol. This value is consistent with another computational result and is broadly consistent with the modest acetone yields observed in product yield studies.

  6. An easy stereoselective access to beta,gamma-aziridino alpha-amino ester derivatives via mannich reaction of benzophenone imines of glycine esters with N-sulfonyl alpha-chloroaldimines. (United States)

    Kiss, Loránd; Mangelinckx, Sven; Sillanpää, Reijo; Fülöp, Ferenc; De Kimpe, Norbert


    Mannich-type addition of benzophenone imine glycinates across newly synthesized N-(p-toluenesulfonyl) alpha-chloroaldimines afforded gamma-chloro-alpha,beta-diamino ester derivatives with moderate diastereoselectivity as separable mixtures of anti and syn diastereomers. The gamma-chloro-alpha,beta-diamino esters were efficiently cyclized under basic conditions to the corresponding beta,gamma-aziridino alpha-amino ester derivatives, representing a new class of conformationally constrained heterocyclic alpha,beta-diamino acid derivatives. The relative configuration of the aziridines was determined via X-ray diffraction analysis. Mechanisms and intermediate transition states to explain the stereochemical outcome of the Mannich reaction with different substrates or under different conditions are proposed. The synthetic importance of the beta,gamma-aziridino alpha-amino ester derivatives is demonstrated by their conversion into the corresponding Boc-protected derivatives and ring opening reactions to alpha,beta-diamino esters and a gamma-amino alpha,beta-unsaturated amino ester.

  7. The structure of {sup 113}Sn from proton and alpha-particle induced reactions

    Energy Technology Data Exchange (ETDEWEB)

    Kaeubler, L. [Technische Univ. Dresden (Germany). Inst. fuer Kern- und Teilchenphysik]|[FZ Rossendorf, Institut fuer Kern- und Hadronenphysik, Postfach 510119, D-01314 Dresden (Germany); Lobach, Y.N. [Institute for Nuclear Research of the Ukrainian Academy of Science, pr. Nauki 47, 252028 Kiev (Ukraine); Trishin, V.V. [Institute for Nuclear Research of the Ukrainian Academy of Science, pr. Nauki 47, 252028 Kiev (Ukraine); Pasternak, A.A. [Physico-Technical Institute ``A. F. Joffe``, Cyclotron Laboratory, ul. Politechnitscheskaja 26, 194021 St.Petersburg (Russian Federation); Kudojarov, M.F. [Physico-Technical Institute ``A. F. Joffe``, Cyclotron Laboratory, ul. Politechnitscheskaja 26, 194021 St.Petersburg (Russian Federation); Prade, H. [FZ Rossendorf, Institut fuer Kern- und Hadronenphysik, Postfach 510119, D-01314 Dresden (Germany); Reif, J. [FZ Rossendorf, Institut fuer Kern- und Hadronenphysik, Postfach 510119, D-01314 Dresden (Germany); Schwengner, R. [FZ Rossendorf, Institut fuer Kern- und Hadronenphysik, Postfach 510119, D-01314 Dresden (Germany); Winter, G. [FZ Rossendorf, Institut fuer Kern- und Hadronenphysik, Postfach 510119, D-01314 Dresden (Germany); Blomqvist, J. [Royal Institute of Technology, Physics Department, Frescati, Frescativaegen 24, S-10405 Stockholm (Sweden); Doering, J. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States)


    The results of in-beam investigations of {sup 113}Sn using the (p,n), (p,3n), ({alpha},n) and ({alpha},2n) reactions are summarized. Excited states have been identified until E{sub x}=4715 MeV and J{sup {pi}}=(27/2{sup -}). For a large number of levels mean lifetimes {tau} have been determined with the DSA method. For the J{sup {pi}}=25/2{sup +} state at E{sub x}=4059 MeV, {tau}=1.0(4) ns has been measured with the {gamma}-RF method. The experimental results are compared with the predictions of shell-model calculations. Most of the positive-parity states may be considered as one- or three-quasiparticle neutron excitations of the 2d{sub 5/2}, 1g{sub 7/2}, 3s{sub 1/2} and 2d{sub 3/2} shells, the negative-parity states as the coupling of one 1h{sub 11/2} neutron to the two- or four-quasiparticle neutron excitations in the even-mass {sup 112}Sn core. For the 25/2{sup +} isomer the three-quasiparticle neutron configuration {nu}(h{sup 2}{sub 11/2} g{sup -1}{sub 7/2}) has been proposed on the basis of a shell-model analysis using the mass-formula formalism. The experimentally observed yrast states in {sup 113}{sub 50}Sn{sub 63} are compared with the corresponding states in the valence mirror nucleus {sup 145}{sub 63}Eu{sub 82} giving remarkable similarities although the parameters for the shell-model calculations differ considerably. The analysis of nearest-neighbour spacing distributions of experimentally obtained 5/2{sup +} states in {sup 113}Sn does not allow definite conclusions about regularity or chaos. (orig.). With 9 figs., 2 tabs.

  8. Use of Be(p,{alpha}) and Be(p,d) Reactions to Determine Be Content in Sapphire

    Energy Technology Data Exchange (ETDEWEB)

    Franklyn, C. B. [Radiation Science Department, Necsa, PO Box 582, Pretoria 0001 (South Africa)


    Since natural coloured sapphire ({alpha}-Al{sub 2}O{sub 3}) commands a high gem stone market price there is a need for a reliable method of identifying artificially coloured sapphire that has an inherently lower value. Diffusing beryllium into sapphire at high temperatures results in a coloured stone virtually indistinguishable from a natural one. Beryllium can occur naturally in sapphire but at levels of <1 ppma. Beryllium diffused sapphire typically contains >10 ppma, which is difficult to determine in a non destructive way. It is possible to utilize nuclear reaction analysis techniques to determine the beryllium content in a macroscopically non destructive way. Kinematically ideal reactions are Be(p,{alpha}) and Be(p,d) which, for Ep = 0.5 to 0.9 MeV, exhibit distinct reaction product signatures well separated from other proton induced reactions in aluminium or oxygen. Due to the lack of comprehensive cross section data for the Be(p,{alpha}) and Be(p,d) reactions in the energy range of interest, a series of measurements were made at the Van de Graaff accelerator facility at Necsa to create a new data base. A further outcome of these measurements was a deviation in reported values for the non-Rutherfordian proton back-scatter cross section. These new data bases, which extend to Ep = 2.6MeV, can now facilitate a procedure for determining beryllium content in sapphire.

  9. Thick target yield measurement of {sup 211}At through the nuclear reaction {sup 209}Bi({alpha}, 2n)

    Energy Technology Data Exchange (ETDEWEB)

    Alfarano, A [Institute for Health and Consumer Protection, IHCP, Joint Research Centre, via E. Fermi 1, 21020 Ispra, Varese (Italy); Abbas, K [Institute for Health and Consumer Protection, IHCP, Joint Research Centre, via E. Fermi 1, 21020 Ispra, Varese (Italy); Holzwarth, U [Institute for Health and Consumer Protection, IHCP, Joint Research Centre, via E. Fermi 1, 21020 Ispra, Varese (Italy); Bonardi, M [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, 20090 Segrate, Milan (Italy); Groppi, F [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, 20090 Segrate, Milan (Italy); Alfassi, Z [Department of Nuclear Engineering, Ben Gurion University, 84105 Beer Sheva (Israel); Menapace, E [ENEA, Applied Physics Division, Bologna (Italy); Gibson, P N [Institute for Health and Consumer Protection, IHCP, Joint Research Centre, via E. Fermi 1, 21020 Ispra, Varese (Italy)


    Radionuclide Therapy (RNT) and Radioimmunotherapy (RIT) are potentially of great interest for cancer therapy. In many therapeutic applications alpha emitters should be much more effective than already-approved beta emitters due to the short range and high linear energy transfer of alpha particles. {sup 213}Bi is an important alpha emitter already used in clinical trials but the half-life of this radioisotope is short (46 minutes) and so its use is limited for certain therapies. {sup 211}At is potentially very interesting for medical purposes because of its longer half-life of 7.2 hours, and suitable decay scheme. We have studied the cyclotron-based production of {sup 211}At via the reaction {sup 209}Bi({alpha}, 2n), this production route probably being the most promising in the long term. The energy dependence of thick target yields and the reaction cross sections for the production of {sup 211}At and {sup 210}At were determined and found to be in good agreement with literature. The best energy to produce {sup 211}At is 28-29 MeV. The possible production of the undesired, highly radiotoxic, and long-lived alpha-emitting {sup 210}Po (138.38 days), which is produced from decay of {sup 210}At, is also discussed.

  10. Deformation behaviour of {gamma}+{alpha}{sub 2} Ti aluminide processed through reaction synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, R.K., E-mail: [Vikram Sarabhai Space Centre, ISRO, Trivandrum, Kerala 695 022 (India); Pant, Bhanu [Vikram Sarabhai Space Centre, ISRO, Trivandrum, Kerala 695 022 (India); Kumar, Vinod [SAIL-RDCIS, Ranchi (India); Agarwala, Vijaya [Indian Institute of Technology, Roorkee 247 667 (India); Sinha, P.P. [Vikram Sarabhai Space Centre, ISRO, Trivandrum, Kerala 695 022 (India)


    {gamma}+{alpha}{sub 2} titanium aluminide alloys made through reaction synthesis have been used for deformation study. Hot isothermal compression test is carried out to study the deformation characteristics of the alloys using Gleeble thermomechanical simulator. Three alloys based on Ti48Al2Cr2Nb0.1B (at%) are tested at different temperatures and at different strain rates. True stress-true strain plots are analyzed along with analysis of tested specimens. Tested specimens are observed under optical and electron microscopes. Presence of various deformation morphologies and phases were confirmed. Microhardness evaluation and transmission electron microscopic examination are used to confirm the presence of different phases. It is found that dynamic recrystallization is mainly playing role in deformation of these alloys. Presence of dynamically recrystallized (DRX) grains and lamellar microstructures is confirmed at the intergranular area and inside the grains, respectively. A nucleation model is suggested for DRX and lamellar grain nucleation during deformation. Attempt has been made to quantify the presence of various phases through optical microscopy. Hot workability map is also suggested on the basis of microstructural and visual observation of compression tested specimens.

  11. [Determination of rate constants of gas-phase reactions of alpha-pinene and beta-pinene with ozone]. (United States)

    Liu, Z R; Hu, D


    alpha-pinene and beta-pinene are the most dominating species among natural terpenes. Terpenes are mainly emitted from forest trees, flowers and grass. In the lower troposphere terpenes can react fast with OH radical, ozone, NO3 radical and ground state oxygen atom. These reactions may contribute to the occurring of aerosols, peroxides (hydrogen peroxide and organic peroxide), carbon cycle (mainly CO), acid rain (organic acids, NO3- and SO4(2-), ozone and active radicals such as OH radical. Reactions with ozone occur both in the daytime and in the night. The study in this field in China began in the late 1980. The main work focus on the source emission and the experimental simulation has just started. It is most of our group's work. In this paper preliminary experimental simulation of the gas-phase reactions of alpha-pinene and beta-pinene with ozone were carried out in the quartz chamber. The rate constants of these reactions were measured using long-path Fourier transform infra-red combined with relative rate constant method. And the rate constants for the gas-phase reactions of alpha-pinene, beta-pinene with ozone were determined as 2.83 x 10(17) cm3.molecule-1.s-1 and 1.48 x 10(17) cm3.molecule-1.s-1 at 1.0 x 10(5) Pa and 296 +/- 3 K. The results are quite similar to the data from Atkinson group. No cyclohexane was added to the reaction system during the measurement to restrain the formation of OH radical. The formation of OH radical could not be quantified, so that the effect of subsidiary reactions induced by OH radical has not been calculated. In the later simulation study and model this effect should be considered.

  12. Cross Section and Tensor Analysing Power of the $\\vec{d}d\\to \\eta\\alpha$ Reaction Near Threshold

    CERN Document Server

    Budzanowski, A; Gebel, R; Hawranek, P; Jahn, R; Jha, V; Kilian, K; Kliczewski, S; Kirillov, Da; Kirillov, Di; Kolev, D; Kravcikova, M; Lesiak, M; Lieb, J; Machner, H; Magiera, A; Maier, R; Martinská, G; Nedev, S; Piskunov, N; Prasuhn, D; Protić, D; Ritman, J; Von Rossen, P; Roy, B J; Sitnik, U; Siudak, R; Tsenov, R; Urbán, J; Vankova, G; Wilkin, C


    The angular distributions of the unpolarised differential cross section and tensor analysing power $A_{xx}$ of the $\\vec{d}d\\to\\alpha \\eta$ reaction have been measured at an excess energy of 16.6 MeV. The ambiguities in the partial-wave description of these data are made explicit by using the invariant amplitude decomposition. This allows the magnitude of the s-wave amplitude to be extracted and compared with results published at lower energies. In this way, firmer bounds could be obtained on the scattering length of the $\\eta \\alpha$ system. The results do not, however, unambiguously prove the existence of a quasi-bound $\\eta \\alpha$ state.

  13. First direct measurement of the $^{11}$C($\\alpha$, p)$^{14}$N stellar reaction by an extended thick-target method

    CERN Document Server

    Hayakawa, S; Kahl, D; Yamaguchi, H; Binh, D N; Hashimoto, T; Wakabayashi, Y; He, J J; Iwasa, N; Kato, S; Komatsubara, T; Kwon, Y K; Teranishi, T


    The $^{11}$C($\\alpha$, p) reaction is an important $\\alpha$-induced reaction competing with $\\beta$-limited hydrogen-burning processes in high-temperature explosive stars. We directly measured its reaction cross sections both for the ground-state transition ($\\alpha$, $p_{0}$) and the excited-state transitions ($\\alpha$, $p_{1}$) and ($\\alpha$, $p_{2}$) at relevant stellar energies 1.3 - 4.5 MeV by an extended thick-target method featuring time of flight for the first time. We revised the reaction rate by numerical integration including the ($\\alpha$, $p_{1}$) and ($\\alpha$, $p_{2}$) contributions and also low-lying resonances of ($\\alpha$, $p_{0}$) using both the present and the previous experimental data which were totally neglected in the previous compilation works. The present total reaction rate lies between the previous ($\\alpha$, $p_{0}$) rate and the total rate of the Hauser-Feshbach statistical model calculation, which is consistent with the relevant explosive hydrogen-burning scenarios such as the $...

  14. Stellar Reactions with Short-Lived Nuclei: {sup 17}F ( p,thinsp{alpha}){sup 14}O

    Energy Technology Data Exchange (ETDEWEB)

    Harss, B.; Greene, J.P.; Henderson, D.; Janssens, R.V.; Jiang, C.L.; Nolen, J.; Pardo, R.C.; Rehm, K.E.; Schiffer, J.P.; Siemssen, R.H.; Sonzogni, A.A.; Uusitalo, J.; Wiedenhoever, I. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Paul, M. [Hebrew University, Jerusalem (Israel); Wang, T.F. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Borasi, F.; Segel, R.E. [Northwestern University, Evanston, Illinois 60439 (United States); Blackmon, J.C.; Smith, M.S. [Physics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6354 (United States); Chen, A.; Parker, P. [Wright Nuclear Structure Laboratory, Yale University, New Haven, Connecticut 06520-8124 (United States)


    A method has been developed that can provide beams of many short-lived nuclei of interest in nucleosynthesis along the rp process path. With a {sup 17}F beam (T{sub 1/2}=64 s ) the excitation function of the {sup 17}F( p,thinsp{alpha}){sup 14} O reaction was measured to determine properties of excited states in {sup 18}Ne . These states influence the rate of the {sup 14}O( {alpha},thinspp){sup 17} F reaction which is important for understanding energy generation and nucleosynthesis in x-ray bursts. The present direct measurements yield a pattern of resonances and cross sections which differ substantially from previous estimates. {copyright} {ital 1999} {ital The American Physical Society}

  15. Spectroscopy of $^{19}$Ne for the thermonuclear $^{15}$O($\\alpha,\\gamma$)$^{19}$Ne and $^{18}$F($p,\\alpha$)$^{15}$O reaction rates

    CERN Document Server

    Parikh, A; de Séréville, N; Wimmer, K; Faestermann, T; Hertenberger, R; Seiler, D; Wirth, H -F; Adsley, P; Fulton, B R; Hammache, F; Kiener, J; Stefan, I


    Uncertainties in the thermonuclear rates of the $^{15}$O($\\alpha,\\gamma$)$^{19}$Ne and $^{18}$F($p,\\alpha$)$^{15}$O reactions affect model predictions of light curves from type I X-ray bursts and the amount of the observable radioisotope $^{18}$F produced in classical novae, respectively. To address these uncertainties, we have studied the nuclear structure of $^{19}$Ne over $E_{x} = 4.0 - 5.1$ MeV and $6.1 - 7.3$ MeV using the $^{19}$F($^{3}$He,t)$^{19}$Ne reaction. We find the $J^{\\pi}$ values of the 4.14 and 4.20 MeV levels to be consistent with $9/2^{-}$ and $7/2^{-}$ respectively, in contrast to previous assumptions. We confirm the recently observed triplet of states around 6.4 MeV, and find evidence that the state at 6.29 MeV, just below the proton threshold, is either broad or a doublet. Our data also suggest that predicted but yet unobserved levels may exist near the 6.86 MeV state. Higher resolution experiments are urgently needed to further clarify the structure of $^{19}$Ne around the proton thresh...

  16. Sperm from hyh mice carrying a point mutation in alphaSNAP have a defect in acrosome reaction.

    Directory of Open Access Journals (Sweden)

    Luis Federico Bátiz

    Full Text Available Hydrocephalus with hop gait (hyh is a recessive inheritable disease that arose spontaneously in a mouse strain. A missense mutation in the Napa gene that results in the substitution of a methionine for isoleucine at position 105 (M105I of alphaSNAP has been detected in these animals. alphaSNAP is a ubiquitous protein that plays a key role in membrane fusion and exocytosis. In this study, we found that male hyh mice with a mild phenotype produced morphologically normal and motile sperm, but had a strongly reduced fertility. When stimulated with progesterone or A23187 (a calcium ionophore, sperm from these animals had a defective acrosome reaction. It has been reported that the M105I mutation affects the expression but not the function of the protein. Consistent with an hypomorphic phenotype, the testes and epididymides of hyh mice had low amounts of the mutated protein. In contrast, sperm had alphaSNAP levels indistinguishable from those found in wild type cells, suggesting that the mutated protein is not fully functional for acrosomal exocytosis. Corroborating this possibility, addition of recombinant wild type alphaSNAP rescued exocytosis in streptolysin O-permeabilized sperm, while the mutant protein was ineffective. Moreover, addition of recombinant alphaSNAP. M105I inhibited acrosomal exocytosis in permeabilized human and wild type mouse sperm. We conclude that the M105I mutation affects the expression and also the function of alphaSNAP, and that a fully functional alphaSNAP is necessary for acrosomal exocytosis, a key event in fertilization.

  17. Mechanisms of the p(He 6,He 5)d, p(He 6,{alpha})t and p(He 6,t){alpha} reactions

    Energy Technology Data Exchange (ETDEWEB)

    Heiberg-Andersen, Henning


    This work was devoted to nucleon induced transfer reactions having the potential to probe the sub-cluster structures of the benchmark halo nucleus He 6, without the question marks the necessarily omitted exchange effects tend to put behind the CRC results when both collision partners are composite systems. Still, the exchange complications entered the analysis in an ironic way: The high Q-value of the p(He 6,{alpha})t and p(He 6, t){alpha} reactions caused sensitivity to the t - {alpha} optical potential at small radii, where the one-nucleon exchange effects are strongest. Since the attempt to throw them out of the extracted tau - {alpha} potential failed, it was necessary to extend the model space to avoid a too difficult modelling of the local equivalent t - {alpha} potential. By this step, all the complications originating from antisymmetrization within a larger model space entered the analysis. However, the persistent failures of the two-channel calculations of this and previous works can hardly be due to incorrect treatment of exchange effects only, so the loss of simplicity is probably illusory. Even at small angles, where the surface processes dominate, none of the two-channel calculations with various choices of t - {alpha} optical potentials managed to reproduce the p(He 6, {alpha})t (p(He 6,t){alpha}) data. This motivated inclusion of sequential transfers through the d + He 5 channel, where the sequential triton transfer process, included just for consistency in the coupling scheme of the four-channel calculation, turned out to be more influent than expected. The satisfactory reproduction of both the p(He 6, He 5)d and the p(He 6,{alpha})t (p(He 6,t){alpha}) data by the four-channel approach and the required re-normalization the real part of the p - He 6 optical potential are strong indications of substantial contributions from sequential transfer of the halo neutrons at this energy. The conclusions that can be drawn from this work are limited by the

  18. Theoretical analysis of kinetic isotope effects on proton transfer reactions between substituted alpha-methoxystyrenes and substituted acetic acids. (United States)

    Wong, Kin-Yiu; Richard, John P; Gao, Jiali


    Primary kinetic isotope effects (KIEs) on a series of carboxylic acid-catalyzed protonation reactions of aryl-substituted alpha-methoxystyrenes (X-1) to form oxocarbenium ions have been computed using the second-order Kleinert variational perturbation theory (KP2) in the framework of Feynman path integrals (PI) along with the potential energy surface obtained at the B3LYP/6-31+G(d,p) level. Good agreement with the experimental data was obtained, demonstrating that this novel computational approach for computing KIEs of organic reactions is a viable alternative to the traditional method employing Bigeleisen equation and harmonic vibrational frequencies. Although tunneling makes relatively small contributions to the lowering of the free energy barriers for the carboxylic acid catalyzed protonation reaction, it is necessary to include tunneling contributions to obtain quantitative estimates of the KIEs. Consideration of anharmonicity can further improve the calculated KIEs for the protonation of substituted alpha-methoxystyrenes by chloroacetic acid, but for the reactions of the parent and 4-NO(2) substituted alpha-methoxystyrene with substituted carboxylic acids, the correction of anharmonicity overestimates the computed KIEs for strong acid catalysts. In agreement with experimental findings, the largest KIEs are found in nearly ergoneutral reactions, DeltaG(o) approximately 0, where the transition structures are nearly symmetric and the reaction barriers are relatively low. Furthermore, the optimized transition structures are strongly dependent on the free energy for the formation of the carbocation intermediate, that is, the driving force DeltaG(o), along with a good correlation of Hammond shift in the transition state structure.

  19. Study of the astrophysically important $\\boldsymbol{^{23}\\mathrm{Na}(\\alpha,p)^{26}\\mathrm{Mg}}$ and $\\boldsymbol{^{23}\\mathrm{Na}(\\alpha,n)^{26}\\mathrm{Al}}$ reactions

    CERN Document Server

    Avila, M L; Almaraz-Calderon, S; Ayangeakaa, A D; Dickerson, C; Hoffman, C R; Jiang, C L; Kay, B P; Lai, J; Nusair, O; Pardo, R C; Santiago-Gonzalez, D; Talwar, R; Ugalde, C


    The $^{23}$Na$(\\alpha,p)^{26}$Mg and $^{23}$Na$(\\alpha,n)^{26}$Al reactions are important for our understanding of the $^{26}$Al abundance in massive stars. The aim of this work is to report on a direct and simultaneous measurement of these astrophysically important reactions using an active target system. The reactions were investigated in inverse kinematics using $^{4}$He as the active target gas in the detector. We measured the excitation functions in the energy range of about 2 to 6 MeV in the center of mass. We have found that the cross sections of the $^{23}$Na$(\\alpha,p)^{26}$Mg and the $^{23}$Na$(\\alpha,n)^{26}$Al reactions are in good agreement with previous experiments, and with statistical model calculations.

  20. New Constraints on the 18F(p,alpha) 15O Rate in Novae from the (d,p) Reaction


    Kozub, R.L.; Bardayan, D. W.; Batchelder, J. C.; Blackmon, J. C.; Brune, C. R.; Champagne, A. E.; Cizewski, J. A.; Davinson, T.; Greife, U.; Gross, C. J.; Jewett, C. C.; Livesay, R. J.; Ma, Z.; Moazen, B. H.; Nesaraja, C. D.


    The degree to which the (p,gamma) and (p,alpha) reactions destroy 18F at temperatures 1-4x10^8 K is important for understanding the synthesis of nuclei in nova explosions and for using the long-lived radionuclide 18F, a target of gamma-ray astronomy, as a diagnostic of nova mechanisms. The reactions are dominated by low-lying proton resonances near the 18F+p threshold (E_x=6.411 MeV in 19Ne). To gain further information about these resonances, we have used a radioactive 18F beam from the Holi...

  1. Measurement of the OXYGEN-17(PROTON, Alpha Particle) Nitrogen -14 Cross Section at Stellar Energies (proton Energies, Resonant Reaction) (United States)

    Blackmon, Jeffery Curtis

    The isotopic abundance ratio 16O/17O has been shown to be a good probe of mass flow and mixing in stars. This ratio is sensitive to the depth of convective mixing which occurs on the giant branch and to the amount of nonconvective mixing occurring on the main sequence. The interpretation of recent observations of this ratio in red giants is limited by a large uncertainty in the value of the 17O(p, alpha)14N reaction rate. This reaction rate is dominated at stellar energies by a resonance at E_{rm x} = 5673 keV in the compound nucleus 18 F, whose strength was previously uncertain. We have carried out a measurement of the ^ {17}O(p,alpha)^{14 }N cross section at proton energies of 75 keV and 65 keV. Thick, high-purity rm Ta_2O _5 targets enriched to 77% ^ {17}O were used in conjunction with beam currents of 0.45 mA and large-solid-angle detectors. The background for the experiment was measured using targets of natural isotopic composition. The resonance peak was observed in the data collected at 75 keV, and we determined the proton width of the 5673 keV state to be 22 +/- 4 neV. This implies a rate for the 17O(p,alpha)^ {14}N reaction that is ten times greater than the typical rates used previously in stellar models.

  2. Study of Interference Effects in the 18F(p,alpha)15O Reaction

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Kyung Yuk [ORNL; Bardayan, Daniel W [ORNL; Blackmon, Jeff C [ORNL; Gregory, Darren R [ORNL; Guidry, Mike W [ORNL; Johnson, Micah [ORNL; KOZUB, RAYMOND L [ORNL; Livesay, Jake [ORNL; Ma, Zhanwen [ORNL; Nesaraja, Caroline D [ORNL; Pain, Steven D [ORNL; Paulauskas, Stanley V [ORNL; Porter-Peden, Matthew D [ORNL; Shriner, Jr., John F [ORNL; Smith, Michael Scott [ORNL; Smith, Nathan A [ORNL; Thomas, Jeffrey S [ORNL


    The {sup 18}F(p,{alpha}a){sup 15}O reaction plays a crucial role in understanding {gamma}-ray emission from novae. Because of the importance of understanding the {sup 18}F + p reactions, a number of studies of the A=19 isobars have been made using stable and exotic beams. The interference effects among J{sup {pi}} = 3/2{sup +} resonances in the {sup 18}F + p system, however, have never been measured, but they can change the S-factor by a factor of 20 at nova energies. R-matrix calculations indicate that the cross sections above the E{sub c.m.} = 665 keV resonance are sensitive to the interference between the E{sub c.m.} = 8, 38, and 665 keV resonances. In order to study the interference effects, an excitation function for the {sup 1}H({sup 18}F,{alpha}){sup 15}O reaction has been measured in the energy range of E{sub c.m.} = 663-877 keV using radioactive {sup 18}F beams at the Holifield Radioactive Ion Beam Facility. By measuring the {sup 18}F(p,{alpha}){sup 15}O cross section off resonance and comparing the cross section with theoretical calculations, we provide the first experimental constraints on the interference of 3/2{sup +} resonances.

  3. Quasi-bound alpha resonant states populated by the {sup 12}C({sup 6}Li, d) reaction

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, M.R.D.; Borello-Lewin, T.; Miyake, H.; Horodynski-Matsushigue, L.B.; Duarte, J.L.M.; Rodrigues, C.L.; Souza, M.A. [Universidade de Sao Paulo (IF/USP), SP (Brazil). Inst. de Fisica; Cunsolo, A.; Cappuzzello, F.; Foti, A.; Agodi, C.; Cavallaro, M. [Istituto Nazionale di Fisica Nucleare (LNS/INFN), Catania (Italy). Lab. Nazionali del Sud; Ukita, G.M. [Universidade de Santo Amaro (UNISA), Sao Paulo, SP (Brazil). Faculdade de Psicologia


    Full text: The alpha cluster phenomenon in the light nuclei structure has been the subject of a long time investigation since the proposal of the Ikeda diagrams [1]. The main purpose of the research program in progress is the investigation of this phenomenon in (x{alpha}) and (x{alpha}+n) nuclei through the ({sup 6}Li, d) alpha transfer reaction [2-4]. Alpha resonant states around the (4{alpha}) threshold in the nucleus {sup 16}O are the focus of the present contribution. In fact, the importance of these resonances at the elements production in stars is recognized, as primarily pointed out by Hoyle in {sup 12}C [6]. The existence of a rotational band with the {alpha} +{sup 12} C (Hoyle) cluster state structure was recently demonstrated by Ohkubo and Hirabayashi [6]. In order to explore this region of interest, measurements of the {sup 12}C({sup 6}Li, d){sup 16}O reaction up to 17 MeV of excitation at an incident energy of 25.5 MeV, have been performed employing the Sao Paulo Pelletron-Enge Split-Pole facility and the nuclear emulsion detection technique (plates Fuji G6B, 50 {mu}m thick). Spectra associated with six scattering angles, from 5 deg to 29 deg in the laboratory frame, each one 50 cm along the focal surface, were measured. Several narrow resonances with a quasi-bound behavior embedded in the continuum were detected and the resolution of 25 keV allowed for the separation of doublets not resolved before [7,8]. The absolute cross sections and the respective deuteron angular distributions were determined and the analysis is in progress. [1] K. Ikeda et al., Prog. Theor. Phys. Suppl. E 68, 464 (1968); H. Horiuchi, K. Ikeda, and Y. Suzuki, ibid. 44, 225 (1978). [2] M.R.D.Rodrigues et al., in12th International Conference on Nuclear Reaction Mechanism, Varenna, Italy, edited by F. Cerutti and A. Ferrari , CERN Proceedings, 2010-2, pp. 331- 335. [3] T. Borello-Lewin et al., Proceedings of SOTANCP2, Brussels, Belgium 2010, edited by P. Descouvemount et al., Int. J

  4. Atmospheric fate of OH initiated oxidation of terpenes. Reaction mechanism of alpha-pinene degradation and secondary organic aerosol formation. (United States)

    Librando, Vito; Tringali, Giuseppe


    This paper studies the reaction products of alpha-pinene, beta-pinene, sabinene, 3-carene and limonene with OH radicals and of alpha-pinene with ozone using FT-IR spectroscopy for measuring gas phase products and HPLC-MS-MS to measure products in the aerosol phase. These techniques were used to investigate the secondary organic aerosol (SOA) formation from the terpenes. The gas phase reaction products were all quantified using reference compounds. At low terpene concentrations (0.9-2.1 ppm), the molar yields of gas phase reaction products were: HCHO 16-92%, HCOOH 10-54% (OH source: H2O2, 6-25 ppm); HCHO 127-148%, HCOOH 4-6% (OH source: CH3ONO, 5-8 ppm). At high terpene concentrations (4.1-13.2 ppm) the results were: HCHO 9-27%, HCOOH 15-23%, CH3(CO)CH3 0-14%, CH3COOH 0-5%, nopinone 24% (only from beta-pinene oxidation), limona ketone 61% (only from limonene oxidation), pinonaldehyde was identified during alpha-pinene degradation (OH source H2O2, 23-30 ppm); HCHO 76-183%, HCOOH 12-15%, CH3(CO)CH3 0-12%, nopinone 17% (from beta-pinene oxidation), limona ketone 48% (from limonene oxidation), pinonaldehyde was identified during alpha-pinene degradation (OH source CH3ONO, 14-16 ppm). Pinic acid, pinonic acid, limonic acid, limoninic acid, 3-caric acid, 3-caronic acid and sabinic acid were identified in the aerosol phase. On the basis of these results, we propose a formation mechanism for pinonic and pinic acid in the aerosol phase explaining how degradation products could influence SOA formation and growth in the troposphere.

  5. Non-statistical decay and $\\alpha$-correlations in the $^{12}$C+$^{12}$C fusion-evaporation reaction at 95 MeV

    CERN Document Server

    Morelli, L; D'Agostino, M; Gulminelli, F; Bruno, M; Abbondanno, U; Appannababu, S; Barlini, S; Bini, M; Casini, G; Cinausero, M; Degerlier, M; Fabris, D; Gelli, N; Gramegna, F; Kravchuk, V L; Marchi, T; Pasquali, G; Piantelli, S; Valdré, S; Raduta, Ad R


    Multiple alpha coincidence and correlations are studied in the reaction $^{12}$C+$^{12}$C at 95 MeV for fusion-evaporation events completely detected in charge. Two specific channels with Carbon and Oxygen residues in coincidence with $\\alpha$-particles are addressed, which are associated with anomalously high branching ratios with respect the predictions by Hauser-Feshbach calculations. Triple alpha emission appears kinematically compatible with a sequential emission from a highly excited Mg. The phase space distribution of $\\alpha$-$\\alpha$ coincidences suggests a correlated emission from a Mg compound, leaving an Oxygen residue excited above the threshold for neutron decay. These observations indicate a preferential $\\alpha$ emission of $^{24}$Mg at excitation energies well above the threshold for $6-\\alpha$ decay.

  6. Measurement of the reaction O-17(\\alpha,n)Ne-20 and its impact on the s process in massive stars

    CERN Document Server

    Best, A; Görres, J; Couder, M; deBoer, R; Falahat, S; Güray, R T; Kontos, A; Kratz, K -L; LeBlanc, P J; Li, Q; O'Brien, S; Özkan, N; Pignatari, M; Sonnabend, K; Talwar, R; Tan, W; Uberseder, E; Wiescher, M; 10.1103/PhysRevC.87.045805


    The ratio between the rates of the reactions O-17(\\alpha,n)Ne-20 and O-17(\\alpha,\\gamma)Ne-21 determines whether O-16 is an efficient neutron poison for the s process in massive stars, or if most of the neutrons captured by O-16(n,\\gamma) are recycled into the stellar environment. This ratio is of particular relevance to constrain the s process yields of fast rotating massive stars at low metallicity. Recent results on the (\\alpha,\\gamma) channel have made it necessary to measure the (\\alpha,n) reaction more precisely and investigate the effect of the new data on s process nucleosynthesis in massive stars. We present a new measurement of the O-17(\\alpha, n) reaction using a moderating neutron detector. In addition, the (\\alpha, n_1) channel has been measured independently by observation of the characteristic 1633 keV \\gamma-transition in Ne-20. The reaction cross section was determined with a simultaneous R-matrix fit to both channels. (\\alpha,n) and (\\alpha, \\gamma) resonance strengths of states lying below ...

  7. Neutron decay of deep hole states and isobaric analog states in Sn-115 populated by the (He-3,alpha) reaction at 102 MeV

    NARCIS (Netherlands)

    Soderman, PO; Ringbom, A; Blomgren, J; Olsson, N; Nilsson, L; Bordewijk, JA; van't Hof, G; Hofstee, MA; van der Ploeg, H; van der Werf, SY; Krasznahorkay, A; Balanda, A; Chmielewska, D; Laurent, H


    Neutron decay of excited hole states and isobaric analog states (IAS) populated by the Sn-116(He-3,alpha) reaction at an energy of 102 MeV has been investigated. The alpha -particles were analysed in a magnetic spectrograph positioned at 1.4 degrees and detected with a multiwire drift chamber. Excit

  8. Prolonged paradoxical reaction to antituberculous treatment after discontinuation of TNF-alpha- blocker therapy with adalimumab. Rare clinical documentation

    Directory of Open Access Journals (Sweden)

    Falkenstern-Ge Roger Fei


    Full Text Available In the past decades, tumor necrosis factor alpha (TNF-a antagonist has been a milestone in the treatment of many chronic inflammatory diseases. TNF antagonist can increase patients´ susceptibility to many different kinds of infections especially those requiring granuloma formations despite regular performance of Screening for latent tuberculosis infection (LTBI. We report 2 cases of patients who developed tuberculosis under treatment with adalimumab, which was discontinued after the diagnosis of tuberculosis. During the tuberculosis therapy they unexpectedly developed a prolonged paradoxical reaction. In both cases we were only able to manage the progress of the paradoxical reaction through high steroid doses. Patients undergoing therapy with TNF- alphablocker are prone to develop tuberculosis infection, which could in turn lead to severe prolonged paradoxical reaction during anti-tuberculous treatment. An increased steroid dose may be required and is sometimes necessary

  9. Cross section measurement of alpha particle induced nuclear reactions on natural cadmium up to 52 MeV

    CERN Document Server

    Ditrói, F; Haba, H; Komori, Y; Aikawa, M


    Cross sections of alpha particle induced nuclear reactions have been measured on thin natural cadmium targets foils in the energy range from 11 to 51.2 MeV. This work was a part of our systematic study on excitation functions of light ion induced nuclear reactions on different target materials. Regarding the cross sections, the alpha induced reactions are not deeply enough investigated. Some of the produced isotopes are of medical interest, others have application in research and industry. The radioisotope $^{117m}$Sn is a very important theranostic (therapeutic + diagnostic) radioisotope, so special care was taken to the results for that isotope. The well-established stacked foil technique followed by gamma-spectrometry with HPGe gamma spectrometers were used. The target and monitor foils in the stack were commercial high purity metal foils. From the irradiated targets $^{117m}$Sn, $^{113}$Sn, $^{110}$Sn, $^{117m,g}$In, $^{116m}$In, $^{115m}$In, $^{114m}$In, $^{113m}$In, $^{111}$In, $^{110m,g}$In, $^{109m}$I...

  10. A gas-tight Cu K alpha x-ray transparent reaction chamber for high-temperature x-ray diffraction analyses of halide gas/solid reactions. (United States)

    Shian, Samuel; Sandhage, Kenneth H


    An externally heated, x-ray transparent reaction chamber has been developed to enable the dynamic high temperature x-ray diffraction (HTXRD) analysis of a gas/solid [TiF(4)(g)/SiO(2)(s)] reaction involving a halide gas reactant formed at elevated temperatures (up to 350 degrees C) from a condensed source (TiF(4) powder) sealed within the chamber. The reaction chamber possessed x-ray transparent windows comprised of a thin (13 microm) internal layer of Al foil and a thicker (125 microm) external Kapton film. After sealing the SiO(2) specimens (diatom frustules or Stober spheres) above TiF(4) powder within the reaction chamber, the chamber was heated to a temperature in the range of 160-350 degrees C to allow for internal generation of TiF(4)(g). The TiF(4)(g) underwent a metathetic reaction with the SiO(2) specimen to yield a TiOF(2)(s) product. HTXRD analysis, using Cu K alpha x rays passed through the Kapton/Al windows of the chamber, was used to track the extent of SiO(2) consumption and/or TiOF(2) formation with time. The Al foil inner layer of the windows protected the Kapton film from chemical attack by TiF(4)(g), whereas the thicker, more transparent Kapton film provided the mechanical strength needed to contain this gas. By selecting an appropriate combination of x-ray transparent materials to endow such composite windows with the required thermal, chemical, and mechanical performance, this inexpensive reaction chamber design may be applied to the HTXRD analyses of a variety of gas/solid reactions.

  11. Theoretical cross section calculations of medical 13N and 18F radioisotope using alpha induced reaction (United States)

    Kılınç, F.; Karpuz, N.; ćetin, B.


    In medical physics, radionuclides are needed to diagnose functional disorders of organs and to diagnose and treat many diseases. Nuclear reactions are significant for the productions of radionuclides. It is important to analyze the cross sections for much different energy. In this study, reactional cross sections calculations on 13N, 18F radioisotopes are with TALYS 1.6 nuclear reaction simulation code. Cross sections calculated and experimental data taken from EXFOR library were compared

  12. Investigation of the use of an {alpha} + Xn reaction channel to enhance the population of superdeformed states in {sup 193}Hg and {sup 195}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Zwartz, G.; Drake, T.E.; Cromaz, M. [Department of Physics, University of Toronto, Toronto, Ontario M5S-1A7 (Canada); Ward, D.; Janzen, V.; Galindo-Uribarri, A. [Chalk River Laboratories, Chalk River, Ontario K0J-1J0 (Canada); Prevost, D.; Waddington, J.; Mullins, S.M. [Department of Physics and Astronomy, McMaster University, Hamilton, Ontario L8S-4K1 (Canada)


    A study was made to determine whether the population of superdeformed states in {sup 193}Hg and {sup 195}Hg can be enhanced by using reactions in which alpha particles are emitted. The search utilized a {sup 184}W({sup 18}O,{alpha} Xn) reaction at 115 and 120 MeV for the {sup 193}Hg study and a {sup 186}W({sup 18}O,{alpha} Xn) reaction at 105 and 110 MeV for the {sup 195}Hg study. Two known superdeformed states of {sup 193}Hg were observed. The intensities of the superdeformed states in {sup 193}Hg populated by a reaction involving the emission of an alpha particle were found to be reduced by at least a factor of four relative to the intensities of these states produced in reactions involving only the emission of neutrons and {gamma}-rays. No rotational bands built on superdeformed states in {sup 195}Hg with transition intensities >0.8% of the total {sup 195}Hg yield were found. Evidence is shown that the energy of the alpha particle that is associated with superdeformed states may be lower than that of alpha particles associated with normally deformed states. (author)

  13. Giant resonances in the {sup 26}Mg(e,e{sup {prime}}{alpha}{sub 0}){sup 22}Ne reaction

    Energy Technology Data Exchange (ETDEWEB)

    Terremoto, L.A.; Likhachev, V.P.; Martins, M.N.; Emrich, H.J.; Fricke, G.; Kroehl, T.; Neff, K.W. [Laboratorio do Acelerador Linear, Instituto de Fisica da Universidade de Sao Paulo, Caixa Postal 66318, 05315-970 Sao Paulo, SP (Brazil)


    The fivefold differential cross section of the reaction {sup 26}Mg(e,e{sup {prime}}c) was measured for transferred momenta of 0.35 and 0.54fm{sup {minus}1} and emitted particle angles from {minus}10{degree} to 270{degree} with respect to the transferred-momentum direction. Angular correlation functions for the emitted {alpha}{sub 0} were obtained from the data. A model-independent analysis allowed us to obtain the E0, E1, and E2 multipole components of the {sup 26}Mg(e,e{sup {prime}}{alpha}{sub 0}){sup 22}Ne cross section, between 14 and 26 MeV of excitation energy. The E1 component shows a bump around 16.5 MeV, associated with the T{sub {lt}} isospin component of the giant dipole resonance. The evaluated strengths associated with the {alpha}{sub 0} decay channel, presented in percentage of the respective energy-weighted sum rules are 0.45(7){percent} for E1, 1.4(3){percent} for E2, and 0.2(1){percent} for E0. {copyright} {ital 1997} {ital The American Physical Society}

  14. Kinetics of self-interstitials reactions in p-type silicon irradiated with alpha particles

    Energy Technology Data Exchange (ETDEWEB)

    Makarenko, L.F., E-mail: [Department of Applied Mathematics and Computer Science, Belarusian State University, Independence Ave. 4, 220030 Minsk (Belarus); Moll, M. [CERN, Geneva (Switzerland); Evans-Freeman, J.H. [University of Canterbury, Christchurch (New Zealand); Lastovski, S.B.; Murin, L.I.; Korshunov, F.P. [Scientific-Practical Materials Research Centre of NAS of Belarus, Minsk (Belarus)


    New findings on the self-interstitial migration in p-type silicon are presented. They are based on experimental studies of the formation kinetics of defects related to interstitial carbon after irradiation with alpha particles. The main parameters characterizing the interaction rate of silicon self-interstitials with substitutional carbon atoms have been determined. A preliminary interpretation of the experimental data is given. The interpretation takes into account different diffusivities of self-interstitials in their singly and doubly ionized states.

  15. $\\mathbf{\\alpha}$-induced reaction cross sections in the mass range $\\mathbf{A \\approx 20 - 50}$: a critical review

    CERN Document Server

    Mohr, Peter


    In a recent review it was shown that the cross sections of $\\alpha$-induced reactions in the $A \\approx 20 - 50$ mass range follow a general and smooth trend in most cases. For comparison of cross sections of different targets at various energies the method of reduced cross sections $\\sigma_{\\rm{red}}$ and reduced energies $E_{\\rm{red}}$ was used. Four outliers were identified: $^{36}$Ar and $^{40}$Ar with unusally small cross sections and $^{23}$Na and $^{33}$S with unusually large cross sections. New data for $^{23}$Na were presented at this NPA-7 conference; contrary to the previous data, these new data fit into the general systematics. In addition, a relation between the most effective energy $E_0$ for astrophysical reaction rates (the so-called Gamow window) and the reduced energy $E_{\\rm{red}}$ is presented.

  16. Differential scanning calorimetry and reaction kinetics studies of {gamma} + {alpha}{sub 2} Ti aluminide

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, R.K., E-mail: [Vikram Sarabhai Space Centre, ISRO, Trivandrum 695 022 (India); Pant, Bhanu [Vikram Sarabhai Space Centre, ISRO, Trivandrum 695 022 (India); Agarwala, Vijaya [Indian Institute of Technology Roorkee, Roorkee 247 667 (India); Sinha, P.P. [Vikram Sarabhai Space Centre, ISRO, Trivandrum 695 022 (India)


    Reaction synthesis method for titanium aluminide processing consists of an exothermic reaction among alloying elements present and primarily between titanium and aluminium particles at specific temperature range. Study of this reaction helps in understanding the process of aluminide formation. Differential scanning calorimetry (DSC) study is the suitable method to study such reactions. In the present work, five different alloy mixtures based on Ti48Al2Cr2Nb0.1B are prepared and DSC study is carried out. Onset temperature, peak temperature and completion temperature of the major exothermic reaction is analyzed at different heating rates. Further, kinetics of the reaction is studied using Johnson-Mehl-Avrami equation. Activation energy and Avrami parameter are calculated and compared with the reported works on binary alloy. It has been observed that exothermic reaction is triggered by melting of aluminium. Boron assists in increasing the enthalpy of reaction by boride formation. Primary reaction product is found to be TiAl{sub 3}. Activation energy as well as Avrami parameter is found to have marginal variation due to small change in alloying elements in different alloys and due to heating rates in the same alloy. -- Highlights: Black-Right-Pointing-Pointer Reaction kinetics studies of Ti-aluminide alloy powder mixtures carried out. Black-Right-Pointing-Pointer Five compositions studied through non-isothermal differential scanning calorimetry. Black-Right-Pointing-Pointer Effect of minor boron addition and role of Ti particle size is noted. Black-Right-Pointing-Pointer Activation energies using JMA equations are between 169.5 and 192.49 kJ mol{sup -1}.

  17. Ghost anomaly and first excited state of sup 8 Be in the sup 9 Be(d,t. alpha. ) sup 4 He reaction at 7 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Szczurek, A.; Bodek, K. (Uniwersytet Jagiellonski, Krakow (Poland). Inst. Fizyki Bochum Univ. (Germany). Inst. fuer Experimentalphysik 1); Jarczyk, L.; Kamys, B.; Strzalkowski, A. (Uniwersytet Jagiellonski, Krakow (Poland). Inst. Fizyki); Krug, J.; Luebcke, W.; Ruehl, H.; Seinke, M.; Stephan, M.; Kamke, D. (Bochum Univ. (Germany). Inst. fuer Experimentalphysik 1)


    The three-body reaction {sup 9}Be + d {yields} t + {alpha} + {alpha} has been investigated in kinematically complete experiments at E{sub d} = 7.0 MeV for {theta}{sub t} 100{sup 0}, {theta}{sub {alpha}} = -40{sup 0} and for {theta}{sub t} = 40{sup 0}, {theta}{sub {alpha}} = 72.5{sup 0} to -162.5{sup 0}. The experimental spectra are dominated by sequential processes via intermediate excited states of {sup 8}Be and {sup 7}Li. R-matrix theory was employed to describe the line shape of the first excited state and the ghost anomaly of the ground state of {sup 8}Be. Use was made of the {alpha}{alpha} phase shifts. The best fits were obtained assuming a channel radius of a{sub {alpha}{alpha}} = 4.5 fm. The average intensity of the ghost anomaly for E{sub {alpha}{alpha}} = 0.35-1.0 MeV is 4.3%/MeV ({theta}{sub t} = 40{sup 0}) and 8%/MeV ({theta}{sub t} = 100{sup 0}). For the first excited state of {sup 8}Be we find E{sub x} = 3.00 MeV and {Gamma}{sub x} = 1.23 MeV(FWHM). (orig.).

  18. Characterization of products formed in the reaction of ozone with alpha-pinene: case for organic peroxides. (United States)

    Venkatachari, Prasanna; Hopke, Philip K


    The generation of reactive oxygen species (ROS) and their subsequent induced pulmonary and systemic oxidative stress has been implicated as an important molecular mechanism of PM-mediated toxicity. However, recent work has shown that there is significant ROS associated with ambient PM. In order to understand the formation mechanisms as well as understand the potential health effects of particle-bound oxidative species, the alpha-pinene-O(3) oxidation chemical system was studied to elucidate the structures of reaction products using liquid chromatography-multiple stage mass spectrometry (LC-MS(n)). The classes of compounds identified based on their multiple stage-MS fragmentation patterns, mechanistic considerations of alpha-pinene-O(3) oxidation, and general fragmentation rules, of the products from this reaction system were highly oxygenated species, predominantly containing hydroperoxide and peroxide functional groups. The oxidant species observed were clearly stable for the 1-3 h that elapsed during aerosol collection and analysis, and probably for much longer, thus rendering it possible for these species to bind onto particles forming fine particulate organic peroxides that concentrate on the particles and could deliver concentrated doses of ROS in vivo to tissue.

  19. Cross-section measurement of the 18F(alpha,p)21Ne reaction and possible implication for neutron production in explosive helium burning

    Energy Technology Data Exchange (ETDEWEB)

    Couture, Aaron Joseph [Los Alamos National Laboratory; Lee, Hye Young [Los Alamos National Laboratory; Couder, Manoel [UNIV OF NOTRE DAME; Falahat, Sascha [UNIV OF NOTRE DAME; Gorres, Joachim [UNIV OF NOTRE DAME; Lamm, Larry O [UNIV OF NOTRE DAME; Le Blanc, P J [UNIV OF NOTRE DAME; O' Brien, Shawn P [UNIV OF NOTRE DAME; Palumbo, Annalia [UNIV OF NOTRE DAME; Stech, Edward J [UNIV OF NOTRE DAME; Strandberg, Elizabeth [UNIV OF NOTRE DAME; Tan, Wanpeng [UNIV OF NOTRE DAME; Ugalde, Claudio [ANL; Wiescher, Michael C. F. [UNIV OF NOTRE DAME


    At the high temperature and density conditions of hot or explosive helium burning, the {sup 18}F({alpha},p){sup 21}Ne reaction may compete successfully wilh the {sup 18}F({beta}{sup +}{nu}) decay. This suggesls {sup 21}Ne({alpha},n) as an alternative neutron source in Ihe r-process. We have determined the total cross section of the {sup 18}F({alpha},p){sup 21}Ne reaction by studying the time-reverse reaction {sup 21}Ne(p,{alpha}){sup 18}F. Using the activation technique, the total reaction yield was measured in the proton beam energy range of 2.3-4.0 MeV, which corresponds to energies of 0.5-2.1 MeV in the {sup 18}F + {alpha} system. The resulting yield curve was analyzed in terms of the thick target formalism and the R-matrix theory. The reaction rate was deduced experimentally for the first time for the temperature of 0.1 < T{sub 9} < I. The experimemal reaction rate was compared with Hauser-Feshbach predictions. The astrophysical implications of the new rate are discussed.

  20. Formation of PdHg by reaction of palladium thin film contacts deposited onto mercuric iodide ({alpha}-HgI{sub 2}) radiation detector crystals

    Energy Technology Data Exchange (ETDEWEB)

    Medlin, D.L. [Sandia National Labs., Livermore, CA (United States); Van Scyoc, J.M. [Carnegie-Mellon Univ., Pittsburgh, PA (United States). Dept. of Electrical and Computer Engineering; Gilbert, T.S. [Carnegie-Mellon Univ., Pittsburgh, PA (United States). Dept. of Electrical and Computer Engineering; Schlesinger, T.E. [Carnegie-Mellon Univ., Pittsburgh, PA (United States). Dept. of Electrical and Computer Engineering; Boehme, D. [Sandia National Labs., Livermore, CA (United States); Schieber, M. [Sandia National Labs., Livermore, CA (United States); Natarajan, M. [TN Technologies, Inc., Round Rock, TX (United States); James, R.B. [Sandia National Labs., Livermore, CA (United States)


    The microstructure and phase distribution of palladium thin films sputter deposited onto {alpha}-HgI{sub 2} for use as electrical contacts in radiation detectors are investigated using electron microscopy. Our results show a limited reaction to form palladium mercuride (PdHg). It is shown that the formation of PdHg via several reaction pathways is thermodynamically feasible. (orig.).

  1. The triple alpha reaction rate and the 2$^+$ resonances in $^{12}$C

    CERN Document Server

    de Diego, R; Fedorov, D V; ~Jensen, A S


    The triple alpha rate is obtained from the three-body bound and continuum states computed in a large box. The results from this genuine full three-body calculation are compared with standard reference rates obtained by two sequential two-body processes. The fairly good agreement relies on two different assumptions about the lowest $2^+$ resonance energy. With the same $2^+$ energy the rates from the full three-body calculation are smaller than those of the standard reference. We discuss the rate dependence on the experimentally unknown $2^+$ energy. Substantial deviations from previous results appear for temperatures above $3$~GK.

  2. Nucleophilic Substitution and Redox Reactions with alpha-Chloro beta-Oxo Sulfenyl Chlorides

    DEFF Research Database (Denmark)

    El-Essawy, Farag A.G.; Yassin, Salah M.; El-Sakka, Ibrahim A.


    Alpha-Chloro sulfenyl chlorides such as 1 and 4 could not be reduced to the corresponding disulfides. Under reducing conditions they are instead dechlorinated to the corresponding thiocarbonyl compounds. Starting from the chroman-4-one derivatives 1 a number of 1,3,4-oxadithiins 3 have been...... prepared. Sulfenyl chlorides 1 and 4 have been derivatized with p-toluenesulfinate, methoxide, and cyanide ions as well as with primary and secondary amines, with thiophenol and with thiobenzoic acid. The molecular structure of thiocyanate 8a has been determined by X-ray crystallography....

  3. alpha1-acid glycoprotein as a putative biomarker for monitoring the development of the type II reactional stage of leprosy. (United States)

    Gupta, Nishma; Shankernarayan, Nallakandy P; Dharmalingam, Kuppamuthu


    Leprosy, a spectral disease manifested on the basis of host immune responses, is complicated by its reactional stages, namely type I reversal reaction (RR) and type II erythema nodosum leprosum (ENL). These reactional stages are characterized by uncontrolled and aberrant immune responses. Biomarkers for reactional stages would aid in early diagnosis, efficient treatment, prevention of neurological complications and prediction of predisposition to reactional stages. In this study, comparative analysis of the serum proteome of leprosy patients by two-dimensional electrophoresis (2DE) followed by mass spectrometry showed differential expression of acute-phase protein alpha (1)-acid glycoprotein (AGP; also known as orosomucoid). AGP levels in untreated ENL cases were significantly higher than in lepromatous leprosy (LL; a non-reactional disease stage) (P=0.0126), RR (P=0.0176) and healthy controls (P=0.0030). These data were confirmed using ELISA. The levels of AGP decreased to normal levels after treatment with multidrug therapy and thalidomide (P =0.0167). In a follow-up study, AGP levels, which were high in the untreated ENL stage, decreased significantly at 5 days ( P=0.0084) and 21 days (P=0.0027) post-treatment. A stage-dependent increase in AGP in an LL patient who progressed into the ENL stage was also shown. Glycosylation analysis by 2DE showed differential expression of acidic glycoforms of AGP in untreated ENL cases. Changes in AGP concentration and differential expression of isoforms correlated with the inflammatory condition in ENL and also with the treatment regimen. Thus, initial validation of AGP as an ENL-specific biomarker and treatment indicator was shown in this study.

  4. Probing the statistical decay and alpha-clustering effects in 12c+12c and 14n+10b reactions

    CERN Document Server

    Morelli, Luca; Agostino, M D; Bruno, M; Gulminelli, F; Cinausero, M; Degerlier, M; Fabris, D; Gramegna, F; Marchi, T; Barlini, S; Bini, M; Casini, G; Gelli, N; Lopez, A; Pasquali, G; Piantelli, S; Valdre', S


    An experimental campaign has been undertaken at INFN Laboratori Nazionali di Legnaro, Italy, in order to progress in our understanding of the statistical properties of light nuclei at excitation energies above particle emission threshold, by measuring exclusive data from fusion-evaporation reactions. A first reaction 12C+12C at 7.9 AMeV beam energy has been measured, using the GARFIELD+Ring Counter experimental setup. Fusion-evaporation events have been exclusively selected. The comparison to a dedicated Hauser-Feshbach calculation allows us to give constraints on the nuclear level density at high excitation energy for light systems ranging from C up to Mg. Out-of-equilibrium emission has been evidenced and attributed both to entrance channel effects favoured by the cluster nature of reaction partners and, in more dissipative events, to the persistence of cluster correlations well above the 24Mg threshold for 6 alphas decay. The 24Mg compound nucleus has been studied with a new measurement 14N + 10B at 5.7 AM...

  5. Reactions between a <111> screw dislocation and <100> interstitial dislocation loops in alpha-iron modelled at atomic-scale

    Energy Technology Data Exchange (ETDEWEB)

    Terentyev, Dmitry [Belgian Nuclear Research Centre, SCK-CEN; Bacon, David J [University of Liverpool; Osetskiy, Yury N [ORNL


    Interstitial dislocation loops with Burgers vector of <100> type are observed in {alpha}-iron irradiated by neutrons or heavy ions, and their population increases with increasing temperature. Their effect on motion of a 1/2<111> edge dislocation was reported earlier 1. Results are presented of a molecular dynamics study of interactions between a 1/2<111> screw dislocation and <100> loops in iron at temperature in the range 100 to 600 K. A variety of reaction mechanisms and outcomes are observed and classified in terms of the resulting dislocation configuration and the maximum stress required for the dislocation to break away. The highest obstacle resistance arises when the loop is absorbed to form a helical turn on the screw dislocation line, for the dislocation cannot glide away until the turn closes and a loop is released with the same Burgers vector as the line. Other than one situation found, in which no dislocation-loop reaction occurs, the weakest obstacle strength is found when the original <100> loop is restored at the end of the reaction. The important role of the cross-slip and the influence of model boundary conditions are emphasised and demonstrated by examples.

  6. Structural Basis on the Catalytic Reaction Mechanism of Novel 1,2-Alpha L-Fucosidase (AFCA) From Bifidobacterium Bifidum

    Energy Technology Data Exchange (ETDEWEB)

    Nagae, M.; Tsuchiya, A.; Katayama, T.; Yamamoto, K.; Wakatsuki, S.; Kato, R.


    1,2-alpha-L-fucosidase (AfcA), which hydrolyzes the glycosidic linkage of Fucalpha1-2Gal via an inverting mechanism, was recently isolated from Bifidobacterium bifidum and classified as the first member of the novel glycoside hydrolase family 95. To better understand the molecular mechanism of this enzyme, we determined the x-ray crystal structures of the AfcA catalytic (Fuc) domain in unliganded and complexed forms with deoxyfuconojirimycin (inhibitor), 2'-fucosyllactose (substrate), and L-fucose and lactose (products) at 1.12-2.10 A resolution. The AfcA Fuc domain is composed of four regions, an N-terminal beta region, a helical linker, an (alpha/alpha)6 helical barrel domain, and a C-terminal beta region, and this arrangement is similar to bacterial phosphorylases. In the complex structures, the ligands were buried in the central cavity of the helical barrel domain. Structural analyses in combination with mutational experiments revealed that the highly conserved Glu566 probably acts as a general acid catalyst. However, no carboxylic acid residue is found at the appropriate position for a general base catalyst. Instead, a water molecule stabilized by Asn423 in the substrate-bound complex is suitably located to perform a nucleophilic attack on the C1 atom of L-fucose moiety in 2'-fucosyllactose, and its location is nearly identical near the O1 atom of beta-L-fucose in the products-bound complex. Based on these data, we propose and discuss a novel catalytic reaction mechanism of AfcA.

  7. Effects of a new triple-$\\alpha$ reaction rate on the helium ignition of accreting white dwarfs

    CERN Document Server

    Saruwatari, Motoaki


    Effects of a new triple-alpha reaction rate on the ignition of carbon-oxygen white dwarfs accreting helium in a binary systems have been investigated. The ignition points determine the properties of a thermonuclear explosion of a Type Ia supernova. We examine the cases of different accretion rates of helium and different initial masses of the white dwarf, which was studied in detail by Nomoto. We find that for all cases from slow to intermediate accretion rates, nuclear burnings are ignited at the helium layers. As a consequence, carbon deflagration would be triggered for the lower accretion rate compared to that of $dM/dt\\simeq 4\\times10^{-8} M_{\\odot} \\rm yr^{-1}$ which has been believed to the lower limit of the accretion rate for the deflagration supernova. Furthermore, off-center helium detonation should result for intermediate and slow accretion rates and the region of carbon deflagration for slow accretion rate is disappeared.

  8. Dipole strength in 144Sm studied via (gamma,n), (gamma,p) and (gamma,alpha) reactions

    CERN Document Server

    Nair, Chithra; Erhard, Martin; Bemmerer, Daniel; Beyer, Roland; Grosse, Eckart; Kosev, Krasimir; Marta, Michele; Rusev, Gencho; Schilling, Klaus-Dieter; Schwengner, Ronald; Wagner, Andreas


    Photoactivation measurements on 144Sm have been performed with bremsstrahlung endpoint energies from 10.0 to 15.5 MeV at the bremsstrahlung facility of the superconducting electron accelerator ELBE of Forschungszentrum Dresden-Rossendorf. The measured activation yield for the 144Sm(gamma,n) reaction is compared with the calculated yield using cross sections from previous photoneutron experiments. The activation yields measured for all disintegration channels 144Sm(gamma,n), (gamma,p) and (gamma,alpha) are compared to the yield calculated by using Hauser-Feshbach statistical models. A new parametrization of the photon strength function is presented and the yield simulated by using the modified photon strength parameters are compared to the experimental data.

  9. The 23Na({\\alpha},p) 26Mg reaction rate at astrophysically relevant energies

    CERN Document Server

    Howard, A M; Fynbo, H O U; Kirsebom, O S; Laursen, K L; Diget, C Aa; Hubbard, N J


    The production of 26 Al in massive stars is sensitive to the 23 Na(a,p) 26 Mg cross section. Recent experimental data suggest the currently recommended cross sections are underestimated by a factor of 40. We present here differential cross sections for the 23 Na(a,p) 26 Mg reaction measured in the energy range E c.m. = 1.7 - 2.5 MeV. Concurrent measurements of Rutherford scattering provide absolute normalisations which are independent of variations in target properties. Angular distributions were measured for both p 0 and p 1 permitting the determination of total cross sections. The results show no significant deviation from the statistical model calculations upon which the recommended rates are based. We therefore retain the previous recommendation without the increase in cross section and resulting stellar reaction rates of a factor of 40, impacting on the 26 Al yield from massive stars by more than a factor of three.


    Directory of Open Access Journals (Sweden)

    Carlo Gustavino


    Full Text Available The 2H(α, γ6Li reaction is the leading process for the production of 6Li in standard Big Bang Nucleosynthesis. Recent observations of lithium abundance in metal-poor halo stars suggest that there might be a 6Li plateau, similar to the well-known Spite plateau of 7Li. This calls for a re-investigation of the standard production channel for 6Li. As the 2H(α, γ6Li cross section drops steeply at low energy, it has never before been studied directly at Big Bang energies. For the first time the reaction has been studied directly at Big Bang energies at the LUNA accelerator. The preliminary data and their implications for Big Bang nucleosynthesis and the purported 6Li problem will be shown.

  11. Reaction of glycolaldehyde with proteins: latent crosslinking potential of alpha-hydroxyaldehydes.



    The Schiff base adducts of glyceraldehyde with hemoglobin undergo Amadori rearrangement to form stable ketoamine structures; this reaction is similar to the nonenzymic glucosylation of proteins. In the present studies the analogous rearrangement of the Schiff base adducts of glycolaldehyde with proteins has been demonstrated. However, the Amadori rearrangement of the Schiff base adduct produces a new aldehyde function, an aldoamine, which is generated in situ and is capable of forming Schiff ...

  12. New $\\alpha$ ANC measurement of the 1/2$^+$ state in $^{17}$O at 6.356 MeV, that dominates the $^{13}$C($\\alpha$,n)$^{16}$O reaction rate at temperatures relevant for the s-process

    CERN Document Server

    Avila, M L; Koshchiy, E; Baby, L T; Belarge, J; Kemper, K W; Kuchera, A N; Santiago-Gonzalez, D


    Background: Accurate knowledge of the $^{13}$C($\\alpha$,$n$)$^{16}$O reaction cross section is important for the understanding of the s-process in AGB stars, since it is considered to be the main source of neutrons. The sub-threshold 1/2$^+$ state at excitation energy of 6.356 MeV in $^{17}$O has a strong influence on the reaction cross section at energies relevant for astrophysics. Several experiments have been performed to determine the contribution of this state to the $^{13}$C($\\alpha,n)^{16}$O reaction rate. Nevertheless, significant discrepancies between different measurements remain. Purpose: The aim of this work is to investigate these discrepancies. Method: An 8 MeV $^{13}$C beam (below the Coulomb barrier) was used to study the $\\alpha$-transfer reaction $^6$Li($^{13}$C,$d$)$^{17}$O. Results: The squared Coulomb modified ANC of the 1/2$^+$ state in $^{17}$O measured in this work is $(\\tilde C^{^{17}\\text{O}(1/2+)}_{\\alpha-^{13}\\text{C}})^2=3.6\\pm0.7\\hspace{0.2cm}\\text{fm}^{-1}$. Conclusions: Discrep...

  13. Study of the {sup 18}F(p,{alpha}){sup 15}O reaction by transfer reaction for application to {gamma}-ray emission from Novae; Etude de la reaction {sup 18}F(p,{alpha}){sup 15}O par reaction de transfert pour application a l'emission {gamma} des Novae

    Energy Technology Data Exchange (ETDEWEB)

    Sereville, N. de


    The gamma emission from novae at/or below 511 keV is due to the annihilation of the positrons produced in the beta + decay of F{sup 18}. The interpretation of this emission through observations made by the Integral satellite for instance, requires a good knowledge of F{sup 18} nucleosynthesis. The reaction rate of the F{sup 18}(p,{alpha})O{sup 15} is the least known because of 2 resonances corresponding to the levels 6.419 and 6.449 MeV of Ne{sup 19} whose proton widths are completely unknown. We have determined these proton widths via the study of one-nucleon transfer reaction D(F{sup 18},p{alpha})N{sup 15} populating equivalent levels in F{sup 19}. We have used a 14 MeV F{sup 18} radioactive beam on a CD{sub 2} target for inverse kinematics studies and the multi-track silicon detector LEDA. A DWBA (Distorted Wave Bound Approximation) has enabled us to determine the proton width of both resonances and has showed that they have an impact in the calculation of the reaction rate. A thorough study of the remaining uncertainties of the reaction rate has been undertaken, particularly for those concerning interferences between these resonances and a higher resonance of Ne{sup 19}. The reaction rate that we have obtained is very similar to the previous rate used but now it rests on a more solid basis.

  14. First application of the Trojan Horse Method with a Radioactive Ion Beam: study of the $^{18}$F($p,{\\alpha}$)$^{15}$O}} reaction at astrophysical energies

    CERN Document Server

    Cherubini, S; Spitaleri, C; Rapisarda, G G; La Cognata, M; Lamia, L; Pizzone, R G; Romano, S; Kubono, S; Yamaguchi, H; Hayakawa, S; Wakabayashi, Y; Iwasa, N; Kato, S; Komatsubara, T; Teranishi, T; Coc, A; de Séréville, N; Hammache, F; Kiss, G; Bishop, S; Binh, D N


    Measurement of nuclear cross sections at astrophysical energies involving unstable species is one of the most challenging tasks in experimental nuclear physics. The use of indirect methods is often unavoidable in this scenario. In this paper the Trojan Horse Method is applied for the first time to a radioactive ion beam induced reaction studying the $^{18}$F($p,{\\alpha}$)$^{15}$O process at low energies relevant to astrophysics via the three body reaction $^{2}$H($^{18}$F,${\\alpha}^{15}$O)n. The knowledge of the $^{18}$F($p, {\\alpha}$)$^{15}$O reaction rate is crucial to understand the nova explosion phenomena. The cross section of this reaction is characterized by the presence of several resonances in $^{19}$Ne and possibly interference effects among them. The results reported in Literature are not satisfactory and new investigations of the $^{18}$F($p,{\\alpha}$)$^{15}$O reaction cross section will be useful. In the present work the spin-parity assignments of relevant levels have been discussed and the astro...

  15. Effects of alpha-amylase reaction mechanisms on analysis of resistant-starch contents. (United States)

    Moore, Samuel A; Ai, Yongfeng; Chang, Fengdan; Jane, Jay-lin


    This study aimed to understand differences in the resistant starch (RS) contents of native and modified starches obtained using two standard methods of RS content analysis: AOAC Method 991.43 and 2002.02. The largest differences were observed in native potato starch, cross-linked wheat distarch phosphate, and high-amylose corn starch stearic-acid complex (RS5) between using AOAC Method 991.43 with Bacillus licheniformis α-amylase (BL) and AOAC Method 2002.02 with porcine pancreatic α-amylase (PPA). To determine possible reasons for these differences, we hydrolyzed raw-starch granules with BL and PPA with equal activity at pH 6.9 and 37°C for up to 84 h and observed the starch granules displayed distinct morphological differences after the hydrolysis. Starches hydrolyzed by BL showed erosion on the surface of the granules; those hydrolyzed by PPA showed pitting on granule surfaces. These results suggested that enzyme reaction mechanisms, including the sizes of the binding sites and the reaction patterns of the two enzymes, contributed to the differences in the RS contents obtained using different methods of RS analysis.

  16. Human alpha-fetal protein immunoassay using fluorescence suppression with fluorescent-bead/antibody conjugate and enzymatic reaction. (United States)

    Ahn, Junhyoung; Shin, Yong-Beom; Lee, JaeJong; Kim, Min-Gon


    The aim of the study was to develop a simple and rapid immunoassay using fluorescent microbeads and enzyme-substrate reactions to measure alpha-fetal protein (AFP) concentrations. We demonstrated the functionality of the fluorescent immunosensor using antibody-conjugated fluorescent latex beads (AB-FLBs) and horseradish peroxidase (HRP) to catalyze a reaction, where the products would precipitate and suppress the fluorescence of AB-FLBs. First, the AB-FLBs were incubated with antigen, biotinylated antibodies (bABs), and streptavidin-HRP (SAv-HRP) to form a sandwich-type immunoreaction. The mixture was then filtered through a membrane to concentrate the beads on a small area. After washing to remove unbound bABs and SAv-HRP, a chromogenic HRP substrate and H2O2 were added to form precipitates on the FLB surface. The suppression of the fluorescence was measured with a fluorescent image analyzer system. Under optimized conditions, AFP could be measured at concentrations as low as 1 pg mL(-1) with a dynamic range up to 100 ng mL(-1).

  17. Absolute hydrogen depth profiling using the resonant $^{1}$H($^{15}$N,$\\alpha\\gamma$)$^{12}$C nuclear reaction

    CERN Document Server

    Reinhardt, Tobias P; Bemmerer, Daniel; Stöckel, Klaus; Wagner, Louis


    Resonant nuclear reactions are a powerful tool for the determination of the amount and profile of hydrogen in thin layers of material. Usually, this tool requires the use of a standard of well-known composition. The present work, by contrast, deals with standard-less hydrogen depth profiling. This approach requires precise nuclear data, e.g. on the widely used $^{1}$H($^{15}$N,$\\alpha\\gamma$)$^{12}$C reaction, resonant at 6.4\\,MeV $^{15}$N beam energy. Here, the strongly anisotropic angular distribution of the emitted $\\gamma$-rays from this resonance has been re-measured, resolving a previous discrepancy. Coefficients of (0.38$\\pm$0.04) and (0.80$\\pm$0.04) have been deduced for the second and fourth order Legendre polynomials, respectively. In addition, the resonance strength has been re-evaluated to (25.0$\\pm$1.5)\\,eV, 10\\% higher than previously reported. A simple working formula for the hydrogen concentration is given for cases with known $\\gamma$-ray detection efficiency. Finally, the absolute approach i...

  18. Structural effects on the beta-scission reaction of tertiary arylcarbinyloxyl radicals. The role of alpha-cyclopropyl and alpha-cyclobutyl groups. (United States)

    Bietti, Massimo; Gente, Giacomo; Salamone, Michela


    A product and time-resolved kinetic study on the reactivity of tertiary arylcarbinyloxyl radicals bearing alpha-cyclopropyl and alpha-cyclobutyl groups has been carried out. Both the 1-cyclopropyl-1-phenylethoxyl (1.) and alpha,alpha-dicyclopropylphenylmethoxyl (2.) radicals undergo beta-scission to give cyclopropyl phenyl ketone as the major or exclusive product with rate constants higher than that measured for the cumyloxyl radical. It is proposed that in the transition state for beta-scission of 1. and 2., formation of the C=O double bond is assisted by overlap with the C-C bonding orbitals of the cyclopropane ring. With tertiary arylcarbinyloxyl radicals bearing alpha-cyclobutyl groups such as the 1-cyclobutyl-1-phenylethoxyl (4.) and 1-cyclobutyl-1-phenylpropoxyl (5.) radicals, the fragmentation regioselectivity is essentially governed by the stability of the radical formed by beta-scission. Accordingly, 4. undergoes exclusive C-cyclobutyl bond cleavage to give acetophenone, whereas with 5., competition between C-cyclobutyl and C-ethyl bond cleavage, leading to propiophenone and cyclobutylphenyl ketone in a 2:1 ratio, is observed.

  19. Total and partial cross sections of the $^{112}$Sn($\\alpha,\\gamma$)$^{116}$Te reaction measured via in-beam $\\gamma$-ray spectroscopy

    CERN Document Server

    Netterdon, L; Scholz, P; Zilges, A


    An extended database of experimental data is needed to address uncertainties of the nuclear-physics input parameters for Hauser-Feshbach calculations. Especially $\\alpha$+nucleus optical model potentials at low energies are not well known. The in-beam technique with an array of high-purity germanium (HPGe) detectors was successfully applied to the measurement of absolute cross sections of an ($\\alpha$,$\\gamma$) reaction on a heavy nucleus at sub-Coulomb energies. The total and partial cross-section values were measured by means of in-beam $\\gamma$-ray spectroscopy. Total and partial cross sections were measured at four different $\\alpha$-particle energies from $E_\\alpha = 10.5$ MeV to $E_\\alpha = 12$ MeV. The measured total cross-section values are in excellent agreement with previous results obtained with the activation technique, which proves the validity of the applied method. The experimental data was compared to Hauser-Feshbach calculations using the nuclear reaction code TALYS. A modified version of the...

  20. Effects of a New Triple-alpha Reaction on X-ray Bursts of a Helium Accreting Neutron Star

    CERN Document Server

    Matsuo, Y; Noda, T; Saruwatari, M; Ono, M; Hashimoto, M; Fujimoto, M


    The effects of a new triple-$\\alpha$ reaction rate (OKK rate) on the helium flash of a helium accreting neutron star in a binary system have been investigated. Since the ignition points determine the properties of a thermonuclear flash of type I X-ray bursts, we examine the cases of different accretion rates, $dM/dt (\\dot{M})$, of helium from $3\\times10^{-10} M_{\\odot} \\rm yr^{-1}$ to $3\\times10^{-8} M_{\\odot} \\rm yr^{-1}$, which could cover the observed accretion rates. We find that for the cases of low accretion rates, nuclear burnings are ignited at the helium layers of rather low densities. As a consequence, helium deflagration would be triggered for all cases of lower accretion rate than $\\dot{M}\\simeq 3\\times10^{-8} M_{\\odot} \\rm yr^{-1}$. We find that OKK rate could be barely consistent with the available observations of the X-ray bursts on the helium accreting neutron star. However this coincidence is found to depend on the properties of crustal heating and the neutron star model.We suggest that OKK r...

  1. Dose-response effects of estrogenic mycotoxins (zearalenone, alpha- and beta-zearalenol on motility, hyperactivation and the acrosome reaction of stallion sperm

    Directory of Open Access Journals (Sweden)

    Colenbrander Ben


    Full Text Available Abstract Background The aim of this study was to investigate the in vitro effects of the Fusarium fungus-derived mycotoxin, zearalenone and its derivatives alpha-zearalenol and beta-zearalenol on motility parameters and the acrosome reaction of stallion sperm. Since the toxic effects of zearalenone and its derivatives are thought to result from their structural similarity to 17beta-estradiol, 17beta-estradiol was used as a positive control for 'estrogen-like' effects. Methods Stallion spermatozoa were exposed in vitro to zearalenone, alpha-zearalenol, beta-zearalenol or 17beta-estradiol at concentrations ranging from 1 pM - 0.1 mM. After 2 hours exposure, motility parameters were evaluated by computer-assisted analysis, and acrosome integrity was examined by flow cytometry after staining with fluoroscein-conjugated peanut agglutinin. Results Mycotoxins affected sperm parameters only at the highest concentration tested (0.1 mM after 2 hours exposure. In this respect, all of the compounds reduced the average path velocity, but only alpha-zearalenol reduced percentages of motile and progressively motile sperm. Induction of motility patterns consistent with hyperactivation was stimulated according to the following rank of potency: alpha-zearalenol >17beta-estradiol > zearalenone = beta-zearalenol. The hyperactivity-associated changes observed included reductions in straight-line velocity and linearity of movement, and an increase in the amplitude of lateral head displacement, while curvilinear velocity was unchanged. In addition, whereas alpha- and beta- zearalenol increased the percentages of live acrosome-reacted sperm, zearalenone and 17beta-estradiol had no apparent effect on acrosome status. In short, alpha-zearalenol inhibited normal sperm motility, but stimulated hyperactive motility in the remaining motile cells and simultaneously induced the acrosome reaction. Beta-zearalenol induced the acrosome reaction without altering motility

  2. Resonance strengths in the 14N(p,gamma)15O and 15N(p,alpha gamma)12C reactions

    CERN Document Server

    Marta, Michele; Bemmerer, Daniel; Beyer, Roland; Broggini, Carlo; Caciolli, Antonio; Erhard, Martin; Fülöp, Zsolt; Grosse, Eckart; Gyürky, György; Hannaske, Roland; Junghans, Arnd R; Menegazzo, Roberto; Nair, Chithra; Schwengner, Ronald; Szücs, Tamás; Vezzú, Simone; Wagner, Andreas; Yakorev, Dmitry


    The 14N(p,gamma)15O reaction is the slowest reaction of the carbon-nitrogen-oxygen cycle of hydrogen burning in stars. As a consequence, it determines the rate of the cycle. The 15N(p,alpha gamma)12C reaction is frequently used in inverse kinematics for hydrogen depth profiling in materials. The 14N(p,gamma)15O and 15N(p,alpha gamma)12C reactions have been studied simultaneously, using titanium nitride targets of natural isotopic composition and a proton beam. The strengths of the resonances at Ep = 1058 keV in 14N(p,gamma)15O and at Ep = 897 and 430 keV in 15N(p,alpha gamma)12C have been determined with improved precision, relative to the well-known resonance at Ep = 278 keV in 14N(p,gamma)15O. The new recommended values are \\omega\\gamma = 0.352$\\pm$0.018, 362$\\pm$20, and 22.0$\\pm$0.9\\,eV for their respective strengths. In addition, the branching ratios for the decay of the Ep = 1058 keV resonance in 14N(p,gamma)15O have been redetermined. The data reported here should facilitate future studies of off-resona...

  3. Separation of reaction mechanisms at low energy. Study of the reactions: {sup 27}Al(d,p) {sup 28}Al, {sup 24}Mg(d,p) {sup 25}Mg, and {sup 24}Mg(d, {alpha}) {sup 22}Na; Sur la separation des mecanismes de reaction a basse energie. Etude des reactions: {sup 27}Al(d,p) {sup 28}Al, {sup 24}Mg(d,p) {sup 25}Mg, et {sup 24}Mg(d, {alpha}) {sup 22}Na

    Energy Technology Data Exchange (ETDEWEB)

    Mermaz, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires


    The two sets of angular distributions of (d,p) reactions on Al and Mg, measured between 2 and 6 MeV, have given the possibility to test, in analysing the statistical fluctuations of cross-section, the validity of the separation of their mean values in two parts, one 'direct', another given by the statistical mechanism. With the same method of analysis we have studied excitation functions for several alpha groups of the reaction {sup 24}Mg(d, {alpha}) {sup 22}Na and given an evidence for an intermediate structure for the alpha channel leading to the 3. excited state of {sup 22}Na. The angular distribution of the wide resonance at 15.9 MeV in {sup 26}Al has been obtained. (author) [French] Les deux ensembles de distributions angulaires des reactions (d,p) sur Al et Mg, mesures entre 2 et 6 MeV, nous ont permis, en analysant les fluctuations statistiques de sections efficaces, de verifier la possibilite de la separation de leurs valeurs moyennes en deux composantes: l'une 'directe', l'autre due au mecanisme statistique. Avec la meme methode d'analyse nous avons etudie les fonctions d'excitation des premiers groupes alpha de la reaction {sup 24}Mg(d,{alpha}) {sup 22}Na et mis en evidence une structure intermediaire pour la voie de reaction aboutissant au 3eme niveau de {sup 22}Na. Nous avons obtenu la distribution angulaire de la resonance large situee a une energie d'excitation de 15,9 MeV dans {sup 26}Al. (auteur)

  4. A compilation of information on the {sup 31}P(p,{alpha}){sup 28}Si reaction and properties of excited levels in the compound nucleus {sup 32}S

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.E.; Smith, D.L. [Argonne National Lab., IL (United States). Technology Development Div.


    This report documents a survey of the literature, and provides a compilation of data contained therein, for the {sup 31}P(p,{alpha}){sup 28}Si reaction. Attention is paid here to resonance states in the compound-nuclear system {sup 32}S formed by {sup 31}P + p, with emphasis on the alpha-particle decay channels, {sup 28}Si + {alpha} which populate specific levels in {sup 28}Si. The energy region near the proton separation energy for {sup 32}S is especially important in this context for applications in nuclear astrophysics. Properties of the excited states in {sup 28}Si are also considered. Summaries of all the located references are provided and numerical data contained in them are compiled in EXFOR format where applicable.

  5. FA-SIFT study of reactions of protonated water and ethanol clusters with [alpha]-pinene and linalool in view of their selective detection by CIMS (United States)

    Dhooghe, F.; Amelynck, C.; Rimetz-Planchon, J.; Schoon, N.; Vanhaecke, F.


    The use of protonated water clusters and protonated ethanol clusters as reagent ions has been evaluated for the resolution of an interference encountered in CIMS when measuring monoterpenes (C10H16) and linalool (C10H18O) simultaneously. To this end, the reactions of H3O+.(H2O)n (n = 1-3), (C2H5OH)mH+ (m = 1-3) and (C2H5OH.H2O)H+ with [alpha]-pinene and linalool have been characterized in a flowing afterglow-selected ion flow tube (FA-SIFT) instrument at a SIFT He buffer gas pressure of 1.43 hPa and a temperature of 298 K. All reactions with linalool were found to occur at the collision limit. The reaction of (C2H5OH)2H+ with [alpha]-pinene proceeds at half the collision rate and both the reactions of (C2H5OH)3H+ and H3O+.(H2O)3 with [alpha]-pinene have a very low rate constant. All other reactions involving [alpha]-pinene proceed at the collision rate. The reactions of H3O+.H2O, H3O+.(H2O)2, C2H5OH2+, (C2H5OH.H2O)H+ and (C2H5OH)2H+ with [alpha]-pinene mainly proceed by proton transfer. Additionally, ligand switching channels have been observed for the reactions of (C2H5OH)2H+ and H3O+.(H2O)2 with [alpha]-pinene. Protonated linalool was observed as a minor product for the reactions of (C2H5OH.H2O)H+ and H3O+.(H2O)n (n = 1-3) with linalool. For all linalool reactions, a contribution of the dissociative proton transfer product at m/z 137 was found and this ion was the main product ion for the reactions with H3O+.H2O, C2H5OH2+ and (C2H5OH.H2O)H+. For the (C2H5OH.H2O)H+/linalool reaction, ligand switching with both water and ethanol has been observed. Major ligand switching channels were observed for the reactions of (C2H5OH)2H+, (C2H5OH)3H+ and H3O+.(H2O)2 with linalool. Also, for the H3O+.(H2O)3/linalool reaction, several ligand switching channels have been observed. These results are discussed in view of their applicability for the selective detection of monoterpenes and linalool with CIMS instrumentation such as SIFT-MS, PTR-MS and APCI-MS.

  6. Synthesis of alpha- and beta-D-glucopyranosyl triazoles by CuAAC 'click chemistry': reactant tolerance, reaction rate, product structure and glucosidase inhibitory properties. (United States)

    Dedola, Simone; Hughes, David L; Nepogodiev, Sergey A; Rejzek, Martin; Field, Robert A


    Cu(I)-catalysed azide alkyne 1,3-dipolar cycloaddition (CuAAC) 'click chemistry' was used to assemble a library of 21 alpha-D- and beta-D-glucopyranosyl triazoles, which were assessed as potential glycosidase inhibitors. In the course of this work, different reactivities of isomeric alpha- and beta-glucopyranosyl azides under CuAAC conditions were noted. This difference was further investigated using competition reactions and rationalised on the basis of X-ray crystallographic data, which revealed significant differences in bond lengths within the azido groups of the alpha- and beta-anomers. Structural studies also revealed a preference for perpendicular orientation of the sugar and triazole rings in both the alpha- and beta-glucosyl triazoles in the solid state. The triazole library was assayed for inhibition of sweet almond beta-glucosidase (GH1) and yeast alpha-glucosidase (GH13), which led to the identification of a set of glucosidase inhibitors effective in the 100 microM range. The preference for inhibition of one enzyme over the other proved to be dependent on the anomeric configuration of the inhibitor, as expected.

  7. Neutron-induced background by an alpha-beam incident on a deuterium gas target and its implications for the study of the 2H(alpha,gamma)6Li reaction at LUNA

    CERN Document Server

    Anders, M; Bellini, A; Aliotta, M; Bemmerer, D; Broggini, C; Caciolli, A; Costantini, H; Corvisiero, P; Davinson, T; Elekes, Z; Erhard, M; Formicola, A; Fülöp, Zs; Gervino, G; Guglielmetti, A; Gustavino, C; Gyürky, Gy; Junker, M; Lemut, A; Marta, M; Mazzocchi, C; Menegazzo, R; Prati, P; Alvarez, C Rossi; Scott, D; Somorjai, E; Straniero, O; Szücs, T


    The production of the stable isotope Li-6 in standard Big Bang nucleosynthesis has recently attracted much interest. Recent observations in metal-poor stars suggest that a cosmological Li-6 plateau may exist. If true, this plateau would come in addition to the well-known Spite plateau of Li-7 abundances and would point to a predominantly primordial origin of Li-6, contrary to the results of standard Big Bang nucleosynthesis calculations. Therefore, the nuclear physics underlying Big Bang Li-6 production must be revisited. The main production channel for Li-6 in the Big Bang is the 2H(alpha,gamma)6Li reaction. The present work reports on neutron-induced effects in a high-purity germanium detector that were encountered in a new study of this reaction. In the experiment, an {\\alpha}-beam from the underground accelerator LUNA in Gran Sasso, Italy, and a windowless deuterium gas target are used. A low neutron flux is induced by energetic deuterons from elastic scattering and, subsequently, the 2H(d,n)3He reaction....

  8. The effect of individual upper alpha band enhancing neurofeedbac kon reaction-time as an indicator of short-term memory in women employee’s

    Directory of Open Access Journals (Sweden)

    Mersedeh Jahanseir


    Full Text Available Background: In neurofeedback systems, people are able to reinforce or hinder their basic EEG rhythms according to operant conditioninin recent studies the effect of neurofeedback training on improvement of working memory has been shown on the healthy subjects. Disadvantage of neurofeedback is the high number of training sessions and high cost. In previous studies, alpha band power within (8-12 Hz has been considered for all subjects. Previous research reached the conclusion that by using individual upper alpha in neurofeedback, learning rate will increase, so the training sessions and the cost of training will be reduced. Material and Methods: In this study, all participants were female, 10 adults (10 women, mean age 33.8 years, SD=3.56 years. Randomly assigned to control and test group, five in test group and five in control group. Each subject performed the memory test four times, two times before the start of the first neurofeedback training and two times after the end of the last neurofeedback session. Eight training sessions were held, each session had three trials. Results: Discriminate response to the color of the drawing, as well as reaction time hadsignificant effects for test group (p0.05. Before and after eight training sessions by individual upper alpha power neurofeedback, reaction time of discriminate response to the color of the drawing for test group decreased and had significant effects (p0.05. Conclusion: Increasing relative individual upper alpha power, caused by neurofeedback training during eight sessions, indicated that this method increases the memory of women employees, and improves the ability of discriminative response to the color (red & green of the drawing as well as reducing reaction time.

  9. New Constraints on the 18F(p,alpha) 15O Rate in Novae from (d,p) Reaction Sum Rules

    CERN Document Server

    Kozub, R L; Batchelder, J C; Blackmon, J C; Brune, C R; Champagne, A E; Cizewski, J A; Davinson, T; Greife, U; Gross, C J; Jewett, C C; Livesay, R J; Ma, Z; Moazen, B H; Nesaraja, C D; Sahin, L; Scott, J P; Shapira, D; Smith, M S; Thomas, J S; Woods, P J


    The degree to which the (p,gamma) and (p,alpha) reactions destroy 18F at temperatures 1-4x10^8 K is important for understanding the synthesis of nuclei in nova explosions and for using the long-lived radionuclide 18F, a target of gamma-ray astronomy, as a diagnostic of nova mechanisms. The reactions are dominated by low-lying proton resonances near the 18F+p threshold (E_x=6.411 MeV in 19Ne). To gain further information about these resonances, we have used a radioactive 18F beam from the Holifield Radioactive Ion Beam Facility to selectively populate corresponding mirror states in 19F via the inverse d(18F,p)19F neutron transfer reaction. Neutron spectroscopic factors were measured for states in 19F in the excitation energy range 0-9 MeV and appropriately scaled to conform to sum rule limits. The results would suggest significantly lower 18F(p,gamma)19Ne and 18F(p,alpha)15O reaction rates than reported previously, thereby increasing the prospect of observing the 511-keV annihilation radiation associated with ...

  10. Estimation of free energy barriers in the cytoplasmic and mitochondrial aspartate aminotransferase reactions probed by hydrogen-exchange kinetics of C alpha-labeled amino acids with solvent

    Energy Technology Data Exchange (ETDEWEB)

    Julin, D.A.; Wiesinger, H.; Toney, M.D.; Kirsch, J.F. (Univ. of California, Berkeley (USA))


    The existence of the postulated quinonoid intermediate in the cytoplasmic aspartate amino-transferase catalyzed transamination of aspartate to oxaloacetate was probed by determining the extent of transfer of tritium from the C alpha position of tritiated L-aspartate to pyridoxamine 5'-phosphate in single turnover experiments in which washout from the back-reaction was obviated by product trapping. The maximum amount of transferred tritium observed was 0.7%, consistent either with a mechanism in which a fraction of the net transamination reaction proceeds through a quinonoid intermediate or with a mechanism in which this intermediate is formed off the main reaction pathway. It is shown that transfer of labeled hydrogen from the amino acid to cofactor cannot be used to differentiate a stepwise from a concerted transamination mechanism. The amount of tritium transferred is a function of the rate constant for torsional equilibration about the epsilon-amino group of Lys-258, the presumptive abstractor of the C alpha proton; the relative rate constants for hydrogen exchange with solvent versus cofactor protonation; and the tritium isotope effect on this ratio. The free energy barriers facing the covalent intermediate between aldimine and keto acid product (i.e., ketimine and possibly quinonoid) were evaluated relatively by comparing the rates of C alpha-hydrogen exchange in starting amino acid with the rates of keto acid formation. The value of theta (= kexge/kprod) was found to be 2.6 for the reaction of cytoplasmic isozyme with aspartate and ca. 0.5 for that of the mitochondrial form with glutamate.

  11. Measurement of the $^{44}$Ti($\\alpha$,p)$^{47}$V reaction cross section, of relevance to $\\gamma$-ray observation of core collapse supernovae, using reclaimed $^{44}$Ti

    CERN Multimedia

    Despite decades of research, fundamental uncertainties remain in the underlying explosion mechanism of core collapse supernovae. One of the most direct methods that might help resolve this problem is a comparison of the predicted to the observed flux of $\\gamma$-rays due to decay of $^{44}$Ti produced in the explosion, as it is believed this could reveal the location of the mass cut, a key hydrodynamical property of the explosion. Such a study is at present limited by the uncertainty in the $^{44}$Ti($\\alpha$,p)$^{47}$V reaction rate. In this experiment we propose to measure the cross section for this reaction at astrophysically relevant energies. The single previous measurement of this reaction was limited to higher energies due to low beam intensities. Here, a more intense beam will be employed, generated from $^{44}$Ti reclaimed as part of the ERAWAST project at PSI.

  12. Nuclear gamma rays from 720-MeV alpha-induced reactions on Al-27 and Si-28 (United States)

    Lieb, B. J.; Plendl, H. S.; Funsten, H. O.; Stronach, C. E.; Lind, V. G.


    Prompt gamma rays from the interaction of 720-MeV alpha particles with Al-27 and Si-28 were detected and analyzed to identify residual nuclei and to determine cross sections for production of specific levels. No gamma-ray transitions were detected from nuclei heavier than the target. From Doppler broadening, the momentum of the residual nuclei was estimated. The results are compared with previous results for 140- and 1600-MeV alphas on Al-27 and approximately 200-MeV positive or negative pions on Al-27 and Si-28 and fitted to a spallation-yield formula.

  13. Experimental measurements of the O15(alpha,gamma)Ne19 reaction rate vs. observations of type I X-ray bursts

    CERN Document Server

    Fisker, J L; Görres, J; Wiescher, M; Cooper, R L; Fisker, Jacob Lund; Tan, Wanpeng; Goerres, Joachim; Wiescher, Michael; Cooper, Randall L.


    Neutron stars in close binary star systems often accrete matter from their companion stars. Thermonuclear ignition of the accreted material in the atmosphere of the neutron star leads to a thermonuclear explosion which is observed as an X-ray burst occurring periodically between hours and days depending on the accretion rate. The ignition conditions are characterized by a sensitive interplay between the continuously accreting fuel supply and depletion by nuclear burning via the hot CNO cycles. Therefore the ignition depends critically on the hot CNO breakout reaction O15(alpha,gamma)Ne19 that regulates the flow between the beta-limited hot CNO cycle and the rapid proton capture process. Until recently, the O15(alpha,gamma)Ne19 reaction rate was not known experimentally and the theoretical estimates carried significant uncertainties. In this paper we report on the astrophysical consequences of the first measurement of this reaction rate on the thermonuclear instability that leads to type I X-ray bursts on accr...

  14. High sensitivity boron quantification in bulk silicon using the {sup 11}B(p,{alpha}{sub 0}){sup 8}Be nuclear reaction

    Energy Technology Data Exchange (ETDEWEB)

    Moro, Marcos V.; Silva, Tiago F. da; Added, Nemitala; Rizutto, Marcia A.; Tabacniks, Manfredo H. [Instituto de Fisica da Universidade de Sao Paulo, C.P. 66318, 05315-970 Sao Paulo, SP (Brazil); Neira, John B.; Neto, Joao B. F. [Institute of Research Tecnology, Cidade Universitaria, SP, 05508-091 (Brazil)


    There is a great need to quantify sub-ppm levels of boron in bulk silicon. There are several methods to analyze B in Si: Nuclear Reaction Analysis using the {sup 11}B(p,{alpha}{sub 0}){sup 8}Be reaction exhibits a quantification limit of some hundreds ppm of B in Si. Heavy Ion Elastic Recoil Detection Analysis offers a detection limit of 5 to 10 at. ppm. Secondary Ion Mass Spectrometry is the method of choice of the semiconductor industry for the analysis of B in Si. This work verifies the use of NRA to quantify B in Si, and the corresponding detection limits. Proton beam with 1.6 up to 2.6 MeV was used to obtain the cross-section of the {sup 11}B(p,{alpha}{sub 0}){sup 8}Be nuclear reaction at 170 Degree-Sign scattering angle. The results show good agreementwith literature indicating that the quantification of boron in silicon can be achieved at 100 ppm level (high sensitivity) at LAMFI-IFUSP with about 16% uncertainty. Increasing the detection solid angle and the collected beam charge, can reduce the detection limit to less than 100 ppm meeting present technological needs.

  15. Glucansucrases : Three-dimensional structures, reactions, mechanism, alpha-glucan analysis and their implications in biotechnology and food applications

    NARCIS (Netherlands)

    Leemhuis, Hans; Pijning, Tjaard; Dobruchowska, Justyna M.; van Leeuwen, Sander S.; Kralj, Slavko; Dijkstra, Bauke W.; Dijkhuizen, Lubbert


    Glucansucrases are extracellular enzymes that synthesize a wide variety of alpha-glucan polymers and oligosaccharides, such as dextran. These carbohydrates have found numerous applications in food and health industries, and can be used as pure compounds or even be produced in situ by generally regar

  16. HPLC-MS determination of the oxidation products of the reaction between alpha- and beta-pinene and OH radicals. (United States)

    Van den Bergh, V; Coeckelberghs, H; Vanhees, I; De Boer, R; Compernolle, F; Vinckier, C


    Biogenic non-methane hydrocarbons such as isoprene, alpha-pinene, and beta-pinene, are emitted by forests in very large quantities. To evaluate the role of alpha- and beta-pinene and their contribution to the global production of trace gases and especially aerosol precursors, a study of the oxidation mechanism of alpha- and beta-pinene with hydroxyl radicals must be conducted. The degradation products of both monoterpenes with hydroxyl radicals were identified and quantified in a fast-flow reactor. The products were collected on a liquid-nitrogen trap coated with a 2,4-DNPH solution to which two internal standards (benzaldehyde-2,4-DNPH and tolualdehyde-2,4-DNPH) had been added. The collection method was based on the in situ conversion of aldehyde and/or ketone compounds to their 2,4-dinitrophenylhydrazone derivatives. The derivatives were analyzed by HPLC-MS using APCI(-). TIC chromatograms and mass spectral data for the various oxidation products are presented. For alpha-pinene, pinonaldehyde is the most important degradation product, with smaller amounts of acetone, formaldehyde, campholenealdehyde, and acetaldehyde. For beta-pinene, nopinone and formaldehyde are the most abundant products, of almost equal importance, whereas acetone and acetaldehyde are minor compounds.

  17. Calculation of excitation functions of proton, alpha and deuteron induced reactions for production of medical radioisotopes {sup 122–125}I

    Energy Technology Data Exchange (ETDEWEB)

    Artun, Ozan, E-mail:; Aytekin, Hüseyin, E-mail:


    In this work, the excitation functions for production of medical radioisotopes {sup 122–125}I with proton, alpha, and deuteron induced reactions were calculated by two different level density models. For the nuclear model calculations, the Talys 1.6 code were used, which is the latest version of Talys code series. Calculations of excitation functions for production of the {sup 122–125}I isotopes were carried out by using the generalized superfluid model (GSM) and Fermi-gas model (FGM). The results have shown that generalized superfluid model is more successful than Fermi-gas model in explaining the experimental results.

  18. A microdosimetric study of {sup 10}B(n,{alpha}){sup 7}Li and {sup 157}Gd(n,{gamma}) reactions for neutron capture therapy

    Energy Technology Data Exchange (ETDEWEB)

    Wang, C.K.C.; Sutton, M.; Evans, T.M. [Georgia Inst. of Tech., Atlanta, GA (United States); Laster, B.H. [Brookhaven National Lab., Upton, NY (United States). Medical Dept.


    This paper presents the microdosimetric analysis for the most interesting cell survival experiment recently performed at the Brookhaven National Laboratory (BNL). In this experiment, the cells were first treated with a gadolinium (Gd) labeled tumor-seeking boronated porphyrin (Gd-BOPP) or with BOPP alone, and then irradiated with thermal neutrons. The resulting cell-survival curves indicate that the {sup 157}Gd(n,{gamma}) reactions are very effective in cell killing. The death of a cell treated with Gd-BOPP was attributed to either the {sup 10}B(n,{alpha}){sup 7}Li reactions or the {sup 157}Gd(n,{gamma}) reactions (or both). However, the quantitative relationship between the two types of reaction and the cell-survival fraction was not clear. This paper presents the microdosimetric analysis for the BNL experiment based on the measured experimental parameters, and the results clearly suggest a quantitative relationship between the two types of reaction and the cell survival fraction. The results also suggest new research in gadolinium neutron capture therapy (GdNCT) which may lead to a more practical modality than the boron neutron capture therapy (BNCT) for treating cancers.

  19. Measurement of the 10 keV resonance in the $^{10}$B($p, \\alpha_0$)$^7$Be reaction via the Trojan Horse Method

    CERN Document Server

    Spitaleri, C; Puglia, S M R; Romano, S; La Cognata, M; Crucilla, V; Pizzone, R G; Rapisarda, G G; Sergi, M L; Del Santo, M Gimenez; Carlin, N; Munhoz, M G; Souza, F A; de Toledo, A Szanto; Tumino, A; Irgaziev, B; Mukhamedzhanov, A; Tabacaru, G; Burjan, V; Kroha, V; Hons, Z; Mrazek, J; Zhou, Shu-Hua; Li, Chengbo; Wen, Qungang; Wakabayashi, Y; Yamaguchi, H


    The $^{10}$B(p,$\\alpha_0$)$^7$Be bare nucleus astrophysical S(E)-factor has been measured for the first time at energies from about 100 keV down to about 5 keV by means of the Trojan Horse Method (THM). In this energy region, the S(E)-factor is strongly dominated by the 8.699 MeV $^{11}$C level (J$^{\\pi}$=$\\frac{5}{2}$$^+$), producing an s-wave resonance centered at about 10 keV in the entrance channel. Up to now, only the high energy tail of this resonant has been measured, while the low-energy trend is extrapolated from the available direct data. The THM has been applied to the quasi-free $^2$H($^{10}$B,$\\alpha_0$$^7$Be)n reaction induced at a boron-beam energy of 24.5 MeV. An accurate analysis brings to the determination of the $^{10}$B(p,$\\alpha_0$)$^7$Be S(E)-factor and of the corresponding electron screening potential $U_e$, thus giving for the first time an independent evaluation of it.

  20. $^7Be(n,\\alpha)^4He$ reaction and the Cosmological Lithium Problem: measurement of the cross section in a wide energy range at n_TOF (CERN)

    CERN Document Server

    Barbagallo, M.; Cosentino, L.; Maugeri, E.; Heinitz, S.; Mengoni, A.; Dressler, R.; Schumann, D.; Käppeler, F.; Colonna, N.; Finocchiaro, P.; Ayranov, M.; Damone, L.; Kivel, N.; Aberle, O.; Altstadt, S.; Andrzejewski, J.; Audouin, L.; Bacak, M.; Balibrea-Correa, J.; Barros, S.; Bécares, V.; Bečvář, F.; Beinrucker, C.; Berthoumieux, E.; Billowes, J.; Bosnar, D.; Brugger, M.; Caamaño, M.; Calviani, M.; Calviño, F.; Cano-Ott, D.; Cardella, R.; Casanovas, A.; Castelluccio, D. M.; Cerutti, F.; Chen, Y. H.; Chiaveri, E.; Cortés, G.; Cortés-Giraldo, M. A.; Cristallo, S.; Diakaki, M.; Domingo-Pardo, C.; Dupont, E.; Duran, I.; Fernandez-Dominguez, B.; Ferrari, A.; Ferreira, P.; Furman, W.; Ganesan, S.; García-Rios, A.; Gawlik, A.; Glodariu, T.; Göbel, K.; Gonçalves, I. F.; González-Romero, E.; Griesmayer, E.; Guerrero, C.; Gunsing, F.; Harada, H.; Heftrich, T.; Heyse, J.; Jenkins, D. G.; Jericha, E.; Katabuchi, T.; Kavrigin, P.; Kimura, A.; Kokkoris, M.; Krtička, M.; Leal-Cidoncha, E.; Lerendegui, J.; Lederer, C.; Leeb, H.; Lo Meo, S.; Lonsdale, S. J.; Losito, R.; Macina, D.; Marganiec, J.; Martínez, T.; Massimi, C.; Mastinu, P.; Mastromarco, M.; Mazzone, A.; Mendoza, E.; Milazzo, P. M.; Mingrone, F.; Mirea, M.; Montesano, S.; Nolte, R.; Oprea, A.; Pappalardo, A.; Patronis, N.; Pavlik, A.; Perkowski, J.; Piscopo, M.; Plompen, A.; Porras, I.; Praena, J.; Quesada, J.; Rajeev, K.; Rauscher, T.; Reifarth, R.; Riego-Perez, A.; Rout, P.; Rubbia, C.; Ryan, J.; Sabate-Gilarte, M.; Saxena, A.; Schillebeeckx, P.; Schmidt, S.; Sedyshev, P.; Smith, A. G.; Stamatopoulos, A.; Tagliente, G.; Tain, J. L.; Tarifeño-Saldivia, A.; Tassan-Got, L.; Tsinganis, A.; Valenta, S.; Vannini, G.; Variale, V.; Vaz, P.; Ventura, A.; Vlachoudis, V.; Vlastou, R.; Vollaire, J.; Wallner, A.; Warren, S.; Weigand, M.; Weiß, C.; Wolf, C.; Woods, P. J.; Wright, T.; Žugec, P.


    The energy-dependent cross section of the 7Be(n,alpha)4He reaction, of interest for the so-called Cosmological Lithium Problem in Big Bang Nucleosynthesis, has been measured for the first time from 10 meV to 10 keV neutron energy. The challenges posed by the short half-life of 7Be and by the low reaction cross section have been overcome at n_TOF thanks to an unprecedented combination of the extremely high luminosity and good resolution of the neutron beam in the new experimental area (EAR2) of the n_TOF facility at CERN, the availability of a sufficient amount of chemically pure 7Be, and a specifically designed experimental setup. Coincidences between the two alpha-particles have been recorded in two Si-7Be-Si arrays placed directly in the neutron beam. The present results are consistent, at thermal neutron energy, with the only previous measurement performed in the 60's at a nuclear reactor. The energy dependence here reported clearly indicates the inadequacy of the cross section estimates currently used in ...

  1. Examination of the role of the $^{14}$O($\\alpha$,$p$)$^{17}$F reaction rate in type I x-ray bursts

    CERN Document Server

    Hu, J; Parikh, A; Xu, S W; Yamaguchi, H; Kahl, D; Ma, P; Su, J; Wang, H W; Nakao, T; Wakabayashi, Y; Teranishi, T; Hahn, K I; Moon, J Y; Jung, H S; Hashimoto, T; Chen, A A; Irvine, D; Lee, C S; Kubono, S


    The $^{14}$O($\\alpha$,$p$)$^{17}$F reaction is one of the key reactions involved in the breakout from the hot-CNO cycle to the rp-process in type I x-ray bursts (XRBs). The resonant properties in the compound nucleus $^{18}$Ne have been investigated through resonant elastic scattering of $^{17}$F+$p$. The radioactive $^{17}$F beam was separated by the CNS Radioactive Ion Beam separator (CRIB) and bombarded a thick H$_2$ gas target at 3.6 MeV/nucleon. The recoiling light particles were measured by three ${\\Delta}$E-E silicon telescopes at laboratory angles of $\\theta$$_{lab}$$\\approx$3$^\\circ$, 10$^\\circ$ and 18$^\\circ$, respectively. Five resonances at $E_{x}$=6.15, 6.28, 6.35, 6.85, and 7.05 MeV were observed in the excitation functions, and their spin-parities have been determined based on an $R$-matrix analysis. In particular, $J^{\\pi}$=1$^-$ was firmly assigned to the 6.15-MeV state which dominates the thermonuclear $^{14}$O($\\alpha$,$p$)$^{17}$F rate below 2 GK. As well, a possible new excited state in $...

  2. Properties of resonant states in 18Ne relevant to key 14O(alpha,p)17F breakout reaction in type I x-ray bursts

    CERN Document Server

    Hu, J; Parikh, A; Xu, S W; Yamaguchi, H; Kahl, D; Ma, P; Su, J; Wang, H W; Nakao, T; Wakabayashi, Y; Teranishi, T; Hahn, K I; Moon, J Y; Sung, H S; Hashimoto, T; Chen, A A; Irvine, D; Lee, C S; Kubono, S


    The $^{14}$O($\\alpha$,$p$)$^{17}$F reaction is one of the key reactions involved in the breakout from the hot-CNO cycle to the rp-process in type I x-ray bursts. The resonant properties in the compound nucleus $^{18}$Ne have been investigated through resonant elastic scattering of $^{17}$F+$p$. The radioactive $^{17}$F beam was separated by the CNS Radioactive Ion Beam separator (CRIB) and bombarded a thick H$_2$ gas target at 3.6 MeV/nucleon. The recoiling light particles were measured by using three ${\\Delta}$E-E silicon telescopes at laboratory angles of $\\theta$$_{lab}$$\\approx$3$^\\circ$, 10$^\\circ$ and 18$^\\circ$, respectively. Five resonances at $E_{x}$=6.15, 6.28, 6.35, 6.85, and 7.05 MeV were observed in the excitation functions. Based on an $R$-matrix analysis, $J^{\\pi}$=1$^-$ was firmly assigned to the 6.15-MeV state. This state dominates the thermonuclear $^{14}$O($\\alpha$,$p$)$^{17}$F rate below 1 GK. We have also confirmed the existence and spin-parities of three states between 6.1 and 6.4 MeV. A...

  3. Secondary. beta. -deuterium isotope effects in decarboxylation and elimination reactions of. cap alpha. -lactylthiamin: intrinsic isotope effects of pyruvate decarboxylase

    Energy Technology Data Exchange (ETDEWEB)

    Kluger, R.; Brandl, M.


    The reactions of the adduct of pyruvate and thiamine, lactylthiamin (2-(lact-2-yl)thiamine), are accurate nonenzymic models for reactions of intermediates formed during catalysis by pyruvate decarboxylase. The enzymatic reaction generates lactylthiamin diphosphate from pyruvate and thiamine diphosphate. ..beta..-Deuterium isotope effects were determined for the nonenzymic reactions, and the results were related to isotope effects on the enzymic reaction. 2-(Lact-2-yl-..beta..-d/sub 3/) thiamine was prepared by condensation of methyl pyruvate-d/sub 3/ with thiamine followed by hydrolysis. The isotope effect for decarboxylation of lactylthiamin in acidic solution at 25/sup 0/C (k/sub H3//k/sub D3/) is 1.09 (standard deviation (SD) 0.015) in pH 3.8, 0.5 M sodium acetate: isotope effect = 1.095 (SD 0.014) in 0.001 M HCl. The reaction was also studied using 38% ethanolic aqueous sodium acetate (pH 3.8 before mixing with ethanol) since the enzymic sites are less polar than water and the reaction is significantly accelerated by the cosolvent. The isotope effect is within statistical range of that for the reaction in water, 1.105 (SD 0.016), indicating that acceleration by the solvent does not change the extent of hyperconjugative stabilization of the transition state relative to the ground state. The isotope effect for the base-catalyzed elimination of pyruvate from lactylthiamin was determined from kinetic studies by using multiwavelength analysis for reactions in pH 11 sodium carbonate solution. The isotope effect (k/sub H3//k/sub D3/) is 1.12 (SD 0.01), which is slightly higher than the effect on decarboxylation.

  4. Excitation functions of alpha particle induced reactions on natTi up to 40 MeV (United States)

    Uddin, M. S.; Scholten, B.


    Excitation functions of the reactions natTi(α,x)48Cr, natTi(α,x)48V and natTi(α,x)46,48Sc were determined by the stacked-foil activation technique up to 40 MeV. The radioactivities produced in the natTi target were measured by γ-ray spectrometry using HPGe detector. The reaction natTi(α,x)51Cr was used to determine the beam parameters. New experimental values for the above reactions have been obtained. An intercomparison of our data with the available literature values has been done. The cross section results obtained in this work could be useful in defining new monitor reactions, radiation safety and isotope production.

  5. Evaluation of nuclear reaction cross section data for the production of (87)Y and (88)Y via proton, deuteron and alpha-particle induced transmutations. (United States)

    Zaneb, H; Hussain, M; Amjad, N; Qaim, S M


    Proton, deuteron and alpha-particle induced reactions on (87,88)Sr, (nat)Zr and (85)Rb targets were evaluated for the production of (87,88)Y. The literature data were compared with nuclear model calculations using the codes ALICE-IPPE, TALYS 1.6 and EMPIRE 3.2. The evaluated cross sections were generated; therefrom thick target yields of (87,88)Y were calculated. Analysis of radio-yttrium impurities and yield showed that the (87)Sr(p, n)(87)Y and (88)Sr(p, n)(88)Y reactions are the best routes for the production of (87)Y and (88)Y respectively. The calculated yield for the (87)Sr(p, n)(87)Y reaction is 104 MBq/μAh in the energy range of 14→2.7MeV. Similarly, the calculated yield for the (88)Sr(p, n)(88)Y reaction is 3.2 MBq/μAh in the energy range of 15→7MeV.

  6. Examination and experimental constraints of the stellar reaction rate factor $N_A < \\sigma v >$ of the $^{18}$Ne($\\alpha$,$p$)$^{21}$Na reaction at temperatures of X-Ray Bursts

    CERN Document Server

    Mohr, P


    The $^{18}$Ne($\\alpha$,$p$)$^{21}$Na reaction is one key for the break-out from the hot CNO-cycles to the $rp$-process. Recent papers have provided reaction rate factors $N_A $ which are discrepant by at least one order of magnitude. The compatibility of the latest experimental results is tested, and a partial explanation for the discrepant $N_A$ is given. A new rate factor is derived from the combined analysis of all available data. The new rate factor is located slightly below the higher rate factor by Matic {\\it et al.}\\ at low temperatures and significantly below at higher temperatures whereas it is about a factor of five higher than the lower rate factor recently published by Salter {\\it et al.}

  7. Excitation function of the alpha particle induced nuclear reactions on enriched 116Cd, production of the theranostic isotope 117mSn (United States)

    Ditrói, F.; Takács, S.; Haba, H.; Komori, Y.; Aikawa, M.; Szűcs, Z.; Saito, M.


    117mSn is one of the radioisotopes can be beneficially produced through alpha particle irradiation. The targets were prepared by deposition of 116Cd metal onto high purity 12 μm thick Cu backing. The average deposited thickness was 21.9 μm. The beam energy was thoroughly measured by Time of Flight (TOF) methods and proved to be 51.2 MeV. For the experiment the well-established stacked foil technique was used. In addition to the Cd targets, Ti foils were also inserted into the stacks for energy and intensity monitoring. The Cu backings were also used for monitoring and as recoil catcher of the reaction products from the cadmium layer. The activities of the irradiated foils were measured with HPGe detector for gamma-ray spectrometry and cross section values were determined. As a result excitation functions for the formation of 117mSn, 117m,gIn, 116mIn, 115mIn and 115m,gCd from enriched 116Cd were deduced and compared with the available literature data and with the results of the nuclear reaction model code calculations EMPIRE 3.2 and TALYS 1.8. Yield curves were also deduced for the measured nuclear reactions and compared with the literature.

  8. High-energy break-up of 6Li as a tool to study the Big-Bang nucleosynthesis reaction 2H(alpha,gamma)6Li

    CERN Document Server

    Hammache, F; Typel, S; Galaviz, D; Sümmerer, K; Coc, A; Uhlig, F; Attallah, F; Caamano, M; Cortina, D; Geissel, H; Hellström, M; Iwasa, N; Kiener, J; Koczon, P; Kohlmeyer, B; Mohr, P; Schwab, E; Schwarz, K; Schümann, F; Senger, P; Sorlin, O; Tatischeff, V; Thibaud, J P; Vangioni, E; Wagner, A; Walus, W


    The recently claimed observations of non-negligible amounts of 6Li in old halo stars have renewed interest in the Big-Bang Nucleosynthesis (BBN) of 6Li. One important ingredient in the predicted BBN abundance of 6Li is the low-energy 2H(alpha,gamma)6Li cross section. Up to now, the only available experimental result for this cross section showed an almost constant astrophysical S-factor below 400 keV, contrary to theoretical expectations. We report on a new measurement of the 2H(alpha,gamma)6Li reaction using the break-up of 6Li at 150 A MeV. Even though we cannot separate experimentally the Coulomb contribution from the nuclear one, we find clear evidence for Coulomb-nuclear interference by analyzing the scattering-angular distributions. This is in-line with our theoretical description which indicates a drop of the S_24-factor at low energies as predicted also by most other models. Consequently, we find even lower upper limits for the calculated primordial 6Li abundance than before.

  9. The impact of the revised $^{17}$O$(p,\\alpha)^{14}$N reaction rate on $^{17}$O stellar abundances and yields

    CERN Document Server

    Straniero, O; Aliotta, M; Best, A; Boeltzig, A; Bemmerer, D; Broggini, C; Caciolli, A; Cavanna, F; Ciani, G F; Corvisiero, P; Cristallo, S; Davinson, T; Depalo, R; Di Leva, A; Elekes, Z; Ferraro, F; Formicola, A; Fülöp, Zs; Gervino, G; Guglielmetti, A; Gustavino, C; Gyürky, G; Imbriani, G; Junker, M; Menegazzo, R; Mossa, V; Pantaleo, F R; Piatti, D; Piersanti, L; Prati, P; Samorjai, E; Strieder, F; Szucs, T; Takács, M P; Trezzi, D


    Context. Material processed by the CNO cycle in stellar interiors is enriched in 17O. When mixing processes from the stellar surface reach these layers, as occurs when stars become red giants and undergo the first dredge up, the abundance of 17O increases. Such an occurrence explains the drop of the 16O/17O observed in RGB stars with mass larger than 1.5 M_\\solar. As a consequence, the interstellar medium is continuously polluted by the wind of evolved stars enriched in 17O . Aims. Recently, the Laboratory for Underground Nuclear Astrophysics (LUNA) collaboration released an improved rate of the 17O(p,alpha)14N reaction. In this paper we discuss the impact that the revised rate has on the 16O/17O ratio at the stellar surface and on 17O stellar yields. Methods. We computed stellar models of initial mass between 1 and 20 M_\\solar and compared the results obtained by adopting the revised rate of the 17O(p,alpha)14N to those obtained using previous rates. Results. The post-first dredge up 16O/17O ratios are about...

  10. Reaction of porous silicon with both end-functionalized organic compounds bearing alpha-bromo and omega-carboxy groups for immobilization of biomolecules. (United States)

    Guo, Dong-Jie; Xiao, Shou-Jun; Xia, Bing; Wei, Shuai; Pei, Jia; Pan, Yi; You, Xiao-Zeng; Gu, Zhong-Ze; Lu, Zuhong


    Both end-functionalized (alpha-bromo and omega-carboxy) compounds were first tested for the radical reaction on the silicon-hydride (Si-H) terminated porous silicon (PSi) with/without the presence of diacyl peroxide initiator under microwave irradiation. Then the carboxylic acid monolayers (CAMs) assembled on PSi through the robust Si-C bonds were converted to amino-reactive linker, N-hydroxysuccinimide (NHS)-ester, terminated monolayers. And finally two proteins of bovine serum albumin (BSA) and lysozyme (Lys) were immobilized through amide bonds. The optimum PSi membrane for protein immobilization without collapse, with parameters of porous radii 4-10 nm and depth 0.2-4.6 mum, was prepared from the (100)-oriented p-type silicon wafer. The chemically converted surface products were monitored with Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and field emission scanning electron microscopy (FESEM).

  11. Nuclear structure studies of sup 1 sup 2 sup 5 Te with (n,gamma), (d,p) and ( sup 3 He,alpha) reactions

    CERN Document Server

    Honzatko, J; Bondarenko, V; Bucurescu, D; Egidy, T V; Ott, J; Schauer, W; Wirth, H F; Doll, C; Gollwitzer, A; Graw, G; Hertenberger, R; Valnion, B D


    Levels in sup 1 sup 2 sup 5 Te were investigated in the range up to 3.3 MeV excitation energy by the (n,gamma), (d,p) and ( sup 3 He,alpha) reactions. Over 160 levels and about 360 gamma-transitions were established, most for the first time. The states below 2.3 MeV with the most complete spectroscopic information were interpreted in terms of the interacting boson-fermion model (IBFM). Unitary treatment of both positive- and negative-parity states is achieved with the same model parameter close to the intermediate case between O(6) and U(5) limits. Excitation energies, electromagnetic transition rates, gamma-branchings and spectroscopic factors are discussed in connection with the possible structures. A family of low-spin negative-parity states has been identified and understood by the IBFM proving their antialigned origin.

  12. Paradoxical reactions induced by tumor necrosis factor-alpha antagonists: A literature review based on 46 cases

    Directory of Open Access Journals (Sweden)

    Rodica Olteanu


    Full Text Available Anti-tumor necrosis factor (TNFα agents have acquired a prominent place in the treatment options for inflammatory disorders. Among the side effects of these agents are the so-called paradoxical reactions which have increasingly been reported in recent years. A review of literature was carried out using Medline (PubMed database from January 2010 to December 2014 to collect all published articles on cases of anti-TNFα-induced psoriasis and psoriatic arthritis. Published articles were identified, reviewed and the relevant data extracted. A total of 22 studies (46 patients fulfilled the inclusion criteria and were selected for analysis. Of the 46 patients, 45 (97.8% developed psoriasis and 1 (2.1% psoriatic arthritis. The mean age of patients was 47 years; three (6.5% patients had a past history of psoriasis. Infliximab caused cutaneous reactions in the most number, 26 (56.5% cases. Thirty seven (80.4%. patients developed primary plaque-type psoriasis. Women accounted for 86.9% of patients. There was complete resolution of psoriasis in 12 (26% patients despite differences in the therapeutic approach. Cessation of the incriminated drug led to resolution of cutaneous lesions in 5 (10.8%, switching to another TNFα antagonist led to resolution in 6 (13% and one (2.1% patient improved despite continuation of the drug. As for the lone case of psoriatic arthritis, drug withdrawal did not result in improvement; only switching to another anti-TNFα agent helped. Since our sample was small, it was not adequately powered to draw any firm conclusions. However, in this analysis, we found that paradoxical reactions occurred predominantly in adult women, there were only isolated cases with a personal history of psoriasis, infliximab was responsible for most cases of these reactions and the most prevalent form was plaque-type psoriasis. The decision whether to continue or discontinue the triggering anti-TNFα agent should be individualized as results are highly

  13. Surface reaction rate and probability of ozone and alpha-terpineol on glass, polyvinyl chloride, and latex paint surfaces. (United States)

    Shu, Shi; Morrison, Glenn C


    Ozone can react homogeneously with unsaturated organic compounds in buildings to generate undesirable products. However, these reactions can also occur on indoor surfaces, especially for low-volatility organics. Conversion rates of ozone with α-terpineol, a representative low-volatility compound, were quantified on surfaces that mimic indoor substrates. Rates were measured for α-terpineol adsorbed to beads of glass, polyvinylchloride (PVC), and dry latex paint, in a plug flow reactor. A newly defined second-order surface reaction rate coefficient, k(2), was derived from the flow reactor model. The value of k(2) ranged from 0.68 × 10(-14) cm(4)s(-1)molecule(-1) for α-terpineol adsorbed to PVC to 3.17 × 10(-14) cm(4)s(-1)molecule(-1) for glass, but was insensitive to relative humidity. Further, k(2) is only weakly influenced by the adsorbed mass but instead appears to be more strongly related to the interfacial activity α-terpineol. The minimum reaction probability ranged from 3.79 × 10(-6) for glass at 20% RH to 6.75 × 10(-5) for PVC at 50% RH. The combination of high equilibrium surface coverage and high reactivity for α-terpineol suggests that surface conversion rates are fast enough to compete with or even overwhelm other removal mechanisms in buildings such as gas-phase conversion and air exchange.

  14. A fluid response: Alpha-amylase reactions to acute laboratory stress are related to sample timing and saliva flow rate. (United States)

    Nagy, Tamás; van Lien, René; Willemsen, Gonneke; Proctor, Gordon; Efting, Marieke; Fülöp, Márta; Bárdos, György; Veerman, Enno C I; Bosch, Jos A


    Salivary alpha-amylase (sAA) is used as a sympathetic (SNS) stress marker, though its release is likely co-determined by SNS and parasympathetic (PNS) activation. The SNS and PNS show asynchronous changes during acute stressors, and sAA responses may thus vary with sample timing. Thirty-four participants underwent an eight-minute memory task (MT) and cold pressor task (CPT). Cardiovascular SNS (pre-ejection period, blood pressure) and PNS (heart rate variability) activity were monitored continuously. Unstimulated saliva was collected repeatedly during and after each laboratory stressor, and sAA concentration (U/ml) and secretion (U/minute) determined. Both stressors increased anxiety. The MT caused an immediate and continued cardiac SNS activation, but sAA concentration increased at task cessation only (+54%); i.e., when there was SNS-PNS co-activation. During the MT sAA secretion even decreased (-35%) in conjunction with flow rate and vagal tone. The CPT robustly increased blood pressure but not sAA. In summary, sAA fluctuations did not parallel changes in cardiac SNS activity or anxiety. sAA responses seem contingent on sample timing and flow rate, likely involving both SNS and PNS influences. Verification using other stressors and contexts seems warranted.

  15. Studies of reaction variables for lipase-catalyzed production of alpha-linolenic acid enriched structured lipid and oxidative stability with antioxidants. (United States)

    Mitra, Kanika; Shin, Jung-Ah; Lee, Jeung-Hee; Kim, Seong-Ai; Hong, Soon-Taek; Sung, Chang-Keun; Xue, Cheng Lian; Lee, Ki-Teak


    Alpha-linolenic acid (ALA) enriched structured lipid (SL) was produced by lipase-catalyzed interesterification from perilla oil (PO) and corn oil (CO). The effects of different reaction conditions (substrate molar ratio [PO/CO 1:1 to 1:3], reaction time [0 to 24 h], and reaction temperature [55 to 65 °C]) were studied. Lipozyme RM IM from Rhizomucor miehei was used as biocatalyst. We obtained 32.39% of ALA in SL obtained under the optimized conditions (molar ratio-1:1 [PO:CO], temperature-60 °C, reaction time-15 h). In SL, the major triacylglycerol (TAG) species (linolenoyl-linolenoyl-linolenoyl glycerol [LnLnLn], linolenoyl-linolenoyl-linoleoyl glycerol [LnLnL]) mainly from PO and linoleoyl-linoleoyl-oleoyl glycerol (LLO), linoleoyl-oleoyl-oleoyl glycerol (LOO), palmitoyl-linoleoyl-oleoyl glycerol (PLO) from CO decreased while linolenoyl-linolenoyl-oleoyl glycerol (LnLnO) (18.41%), trilinolein (LLL) (9.06%), LLO (16.66%), palmitoyl-linoleoyl-linoleoyl glycerol (PLL) (9.69%) were increased compared to that of physical blend. Total tocopherol content (28.01 mg/100 g), saponification value (SV) (192.2), and iodine value (IV) (161.9) were obtained. Furthermore, oxidative stability of the SL was also investigated by addition of 3 different antioxidants (each 200 ppm of rosemary extract [SL-ROS], BHT [SL-BHT], catechin [SL-CAT]) was added into SL and stored in 60 °C oven for 30 d. 2-Thiobabituric acid-reactive substances (TBARS) value was 0.16 mg/kg in SL-CAT and 0.18 mg/kg in SL-ROS as compared with 0.22 mg/kg in control (SL) after oxidation. The lowest peroxide value (POV, 200.9 meq/kg) and longest induction time (29.88 h) was also observed in SL-CAT.

  16. Study of the $^{44}$Ti$(\\alpha,p)^{47}$V47 reaction and implications for core collapse supernovae

    CERN Document Server

    Margerin, V; Davinson, T; Dressler, R; Fallis, J; Kankainen, A; Laird, A M; Lotay, G; Mountford, D J; Murphy, C D; Seiffert, C; Schumann, D; Stowasser, T; Stora, T; Wang, C H -T; Woods, P J


    The underlying physics triggering core collapse supernovae is not fully understood but observations of material ejected during such events helps to solve this puzzle. In particular, several satellite based γ -ray observations of the isotope 44 Ti have been reported recently. Conveniently, the amount of this isotope in stellar ejecta is thought to depend critically on the explosion mechanism. The most influential reaction to the amount of 44 Ti in supernovae is 44 Ti ( α , p ) 47 V. Here we report on a direct study of this reaction conducted at the REX-ISOLDE facility, CERN. The experiment was performed with a 44 Ti beam at E lab = 2 . 16 MeV / u, corresponding to an energy distribution, for reacting α -particles, centred on E cm = 4 . 15 with a 1 σ width of 0.23 MeV. This is, for the first time, well within the Gamow window for core collapse supernovae. The material from which the 44 Ti beam was extracted originates from highly irradiated components of the SINQ spallation neutron source of the Paul Scherr...

  17. Is \\gamma-ray emission from novae affected by interference effects in the 18F(p,\\alpha)15O reaction?

    CERN Document Server

    Laird, A M; Murphy, A St J; Wimmer, K; Chen, A A; Deibel, C M; Faestermann, T; Fox, S P; Fulton, B R; Hertenberger, R; Irvine, D; José, J; Longland, R; Mountford, D; Sambrook, B; Seiler, D; Wirth, H -F


    The 18F(p,\\alpha)15O reaction rate is crucial for constraining model predictions of the \\gamma-ray observable radioisotope 18F produced in novae. The determination of this rate is challenging due to particular features of the level scheme of the compound nucleus, 19Ne, which result in interference effects potentially playing a significant role. The dominant uncertainty in this rate arises from interference between J\\pi=3/2+ states near the proton threshold (Sp = 6.411 MeV) and a broad J\\pi=3/2+ state at 665 keV above threshold. This unknown interference term results in up to a factor of 40 uncertainty in the astrophysical S-factor at nova temperatures. Here we report a new measurement of states in this energy region using the 19F(3He,t)19Ne reaction. In stark contrast with previous assumptions we find at least 3 resonances between the proton threshold and Ecm=50 keV, all with different angular distributions. None of these are consistent with J\\pi= 3/2+ angular distributions. We find that the main uncertainty ...

  18. Investigation of the impact of the $^{39}$Ar(n , $\\alpha)^{36}$S reaction on the nucleosynthesis of the rare isotope $^{36}$S

    CERN Multimedia

    Geltenbort, P


    The origin of the rare, neutron rich isotope $^{36}$S remains a debated question. One of the key reactions in the s-process nucleosynthesis network leading to $^{36}$S is $^{39}$Ar(n , $\\alpha) ^{36}\\!$S. This reaction has never been studied so far, which is due to the fact that $^{39}$Ar is a radioactive (T$_{1/2}$ = 269 y) gas, which is not commercially available. During a three days experimental campaign, an optimized $^{39}$Ar sample was prepared at ISOLDE. A dedicated titaniumoxide target (8 g/cm$^{2}$) was bombarded with 1 GeV protons from the PS Booster. In order to obtain a pure argon beam, a water-cooled transfer line was used to freeze-out less volatile isobars before they can reach the ion source. Adding stable argon with a calibrated leak to the ion source enabled to determine the ionization efficiency (3.5%). For the isotope separation, the low-mass side (GLM) of the General Purpose Separator was used. After magnetic separation, $^{39}$Ar ions (1+) were implanted at 60 keV in a 12 mm thick alumin...

  19. Measurements of neutron-induced capture and fission reactions on $^{235}$ U: cross sections and ${\\alpha}$ ratios, photon strength functions and prompt ${\\gamma}$-ray from fission

    CERN Multimedia

    We propose to measure the neutron-induced capture cross section of the fissile isotope $^{235}$U using a fission tagging set-up. This new set-up has been tested successfully in 2010 and combines the n_TOF 4${\\pi}$ Total Absorption Calorimeter (TAC) with MicroMegas (MGAS) fission detectors. It has been proven that such a combination of detectors allows distinguishing with very good reliability the electromagnetic cascades from the capture reactions from dominant ${\\gamma}$-ray background coming from the fission reactions. The accurate discrimination of the fission background is the main challenge in the neutron capture cross section measurements of fissile isotopes. The main results from the measurement will be the associated capture cross section and ${\\alpha}$ ratio in the resolved (0.3-2250 eV) and unresolved (2.25-30 keV) resonance regions. According to the international benchmarks and as it is mentioned in the NEA High Priority Request List (HPRL), the 235U(n,${\\gamma}$) cross section is of utmost impo...

  20. Does Dietary Deoxynivalenol Modulate the Acute Phase Reaction in Endotoxaemic Pigs?—Lessons from Clinical Signs, White Blood Cell Counts, and TNF-Alpha

    Directory of Open Access Journals (Sweden)

    Tanja Tesch


    Full Text Available We studied the interaction between deoxynivalenol (DON-feeding and a subsequent pre- and post-hepatic immune stimulus with the hypothesis that the liver differently mediates the acute phase reaction (APR in pigs. Barrows (n = 44 were divided into a DON-(4.59 mg DON/kg feed and a control-diet group, surgically equipped with permanent catheters pre- (V. portae hepatis and post-hepatic (V. jugularis interna and infused either with 0.9% NaCl or LPS (7.5 µg/kg BW. Thus, combination of diet (CON vs. DON and infusion (CON vs. LPS, jugular vs. portal created six groups: CON_CONjug.-CONpor., CON_CONjug.-LPSpor., CON_LPSjug.-CONpor., DON_CONjug.-CONpor., DON_CONjug.-LPSpor., DON_LPSjug.-CONpor.. Blood samples were taken at −30, 15, 30, 45, 60, 75, 90, 120, 150, 180 min relative to infusion and analyzed for leukocytes and TNF-alpha. Concurrently, clinical signs were scored and body temperature measured during the same period. LPS as such induced a dramatic rise in TNF-alpha (p < 0.001, hyperthermia (p < 0.01, and severe leukopenia (p < 0.001. In CON-fed pigs, an earlier return to physiological base levels was observed for the clinical complex, starting at 120 min post infusionem (p < 0.05 and persisting until 180 min. DON_LPSjug.-CONpor. resulted in a lower temperature rise (p = 0.08 compared to CON_LPSjug.-CONpor.. In conclusion, APR resulting from a post-hepatic immune stimulus was altered by chronic DON-feeding.

  1. Some Calculated (p,α Cross-Sections Using the Alpha Particle Knock-On and Triton Pick-Up Reaction Mechanisms: An Optimisation of the Single-Step Feshbach–Kerman–Koonin (FKK Theory

    Directory of Open Access Journals (Sweden)

    Felix S. Olise


    Full Text Available The Feshbach–Kerman–Koonin (FKK multi-step direct (MSD theory of pre-equilibrium reactions has been used to compute the single-step cross-sections for some (p,α reactions using the knock-on and pick-up reaction mechanisms at two incident proton energies. For the knock-on mechanism, the reaction was assumed to have taken place by the direct ejection of a preformed alpha cluster in a shell-model state of the target. But the reaction was assumed to have taken place by the pick-up of a preformed triton cluster (also bound in a shell-model state of the target core by the incident proton for the pick-up mechanism. The Yukawa forms of potential were used for the proton-alpha (for the knock-on process and proton-triton (for the pick-up process interaction and several parameter sets for the proton and alpha-particle optical potentials. The calculated cross-sections for both mechanisms gave satisfactory fits to the experimental data. Furthermore, it has been shown that some combinations of the calculated distorted wave Born approximation cross-sections for the two reaction mechanisms in the FKK MSD theory are able to give better fits to the experimental data, especially in terms of range of agreement. In addition, the theory has been observed to be valid over a wider range of energy.

  2. Some calculated (p,α) cross-sections using the alpha particle knock-on and triton pick-up reaction mechanisms: An optimisation of the single-step Feshbach-Kerman-Koonin (FKK) theory

    Energy Technology Data Exchange (ETDEWEB)

    Olise, Felix S.; Ajala, Afis; Olamiyl, Hezekiah B. [Dept. of Physics and Engineering Physics, Obafemi Awolowo University, Ile-Ife (Nigeria)


    The Feshbach-Kerman-Koonin (FKK) multi-step direct (MSD) theory of pre-equilibrium reactions has been used to compute the single-step cross-sections for some (p,α) reactions using the knock-on and pick-up reaction mechanisms at two incident proton energies. For the knock-on mechanism, the reaction was assumed to have taken place by the direct ejection of a preformed alpha cluster in a shell-model state of the target. But the reaction was assumed to have taken place by the pick-up of a preformed triton cluster (also bound in a shell-model state of the target core) by the incident proton for the pick-up mechanism. The Yukawa forms of potential were used for the proton-alpha (for the knock-on process) and proton-triton (for the pick-up process) interaction and several parameter sets for the proton and alpha-particle optical potentials. The calculated cross-sections for both mechanisms gave satisfactory fits to the experimental data. Furthermore, it has been shown that some combinations of the calculated distorted wave Born approximation cross-sections for the two reaction mechanisms in the FKK MSD theory are able to give better fits to the experimental data, especially in terms of range of agreement. In addition, the theory has been observed to be valid over a wider range of energy.

  3. Two novel nonradioactive polymerase chain reaction-based assays of dried blood spots, genomic DNA, or whole cells for fast, reliable detection of Z and S mutations in the alpha 1-antitrypsin gene

    DEFF Research Database (Denmark)

    Andresen, B S; Knudsen, I; Jensen, P K;


    Two new nonradioactive polymerase chain reaction (PCR)-based assays for the Z and S mutations in the alpha 1-antitrypsin gene are presented. The assays take advantage of PCR-mediated mutagenesis, creating new diagnostic restriction enzyme sites for unambiguous discrimination between test samples...


    NARCIS (Netherlands)



    BACKGROUND: We have modified a polymerase chain reaction (PCR)-aided transcript titration assay (1) in order to allow quantitation of low amounts of DNA topoisomerase II alpha mRNA in small RNA samples. EXPERIMENTAL DESIGN: The titration assay was used to quantitate the amount of DNA topoisomerase I

  5. A proposed direct measurement of cross section at Gamow window for key reaction $^{19}$F($p$,$\\alpha$)$^{16}$O in Asymptotic Giant Branch stars with a planned accelerator in CJPL

    CERN Document Server

    He, J J; Ma, S B; Hu, J; Zhang, L Y; Fu, C B; Zhang, N T; Lian, G; Su, J; Li, Y J; Yan, S Q; Shen, Y P; Hou, S Q; Jia, B L; Zhang, T; Zhang, X P; Guo, B; Kubono, S; Liu, W P


    In 2014, the National Natural Science Foundation of China (NSFC) approved the Jinping Underground Nuclear Astrophysics laboratory (JUNA) project, which aims at direct cross-section measurements of four key stellar nuclear reactions right down to the Gamow windows. In order to solve the observed fluorine overabundances in Asymptotic Giant Branch (AGB) stars, measuring the key $^{19}$F($p$,$\\alpha$)$^{16}$O reaction at effective burning energies (i.e., at Gamow window) is established as one of the scientific research sub-projects. The present paper describes this sub-project in details, including motivation, status, experimental setup, yield and background estimation, aboveground test, as well as other relevant reactions.

  6. Excitation function of the alpha particle induced nuclear reactions on enriched $^{116}$Cd, production of the theranostic isotope $^{117m}$Sn

    CERN Document Server

    Ditrói, F; Haba, H; Komori, Y; Aikawa, M; Szűcs, Z; Saito, M


    $^{117m}$Sn is one of the radioisotopes can be beneficially produced through alpha particle irradiation. The targets were prepared by deposition of $^{116}$Cd metal onto high purity 12 $\\mu$m thick Cu backing. The average deposited thickness was 21.9 $\\mu$m. The beam energy was thoroughly measured by Time of Flight (TOF) methods and proved to be 51.2 MeV. For the experiment the well-established stacked foil technique was used. In addition to the Cd targets, Ti foils were also inserted into the stacks for energy and intensity monitoring. The Cu backings were also used for monitoring and as recoil catcher of the reaction products from the cadmium layer. The activities of the irradiated foils were measured with HPGe detector for gamma-ray spectrometry and cross section values were determined. As a result excitation functions for the formation of $^{117m}$Sn, $^{117m,g}$In, $^{116m}$In, $^{115m}$In and $^{115m,g}$Cd from enriched $^{116}$Cd were deduced and compared with the available literature data and with the...

  7. An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. (United States)

    Genevée, C; Diu, A; Nierat, J; Caignard, A; Dietrich, P Y; Ferradini, L; Roman-Roman, S; Triebel, F; Hercend, T


    We report here the characterization of a series of T cell receptor (TcR) V alpha or V beta subfamily-specific oligonucleotide primers. Criteria that have guided the design of each oligonucleotide include appropriate thermodynamic parameters as well as differential base-pairing scores with related and unrelated target sequences. The specificity of the oligonucleotides for each V alpha or V beta subfamily was tested by polymerase chain reaction (PCR) on both a series of TcR encoding plasmid DNA and clonal T cell populations. Unexpected cross-reactivities were observed with plasmid cDNA sequences corresponding to unrelated subfamily gene segments. This led to the synthesis of additional series of oligonucleotides to obtain a relevant panel. A series of V alpha 1-w29/V beta 1-w24 TcR subfamily-specific oligonucleotides was eventually selected which generates little, if any, cross-reactivity. The use of C alpha or C beta primers for the amplification of internal positive control templates (i.e. C beta for the V alpha series and C alpha for the V beta series) has been tested in PCR performed with cDNA derived from peripheral blood lymphocytes; it was shown not to alter the amplification of the V subfamily-specific DNA fragments. This panel of oligonucleotides will be helpful in the study of TcRV gene segment usage and, thus, may lead to a better characterization of T cell responses in physiological and pathological situations.

  8. Alpha Thalassemia (United States)

    Alpha Thalassemia Physicians often mistake alpha thalassemia trait for iron deficiency anemia and incorrectly prescribe iron supplements that have no effect 1 on the anemia. αα αα Normal alpha ...

  9. Investigation of the Pygmy Dipole Resonance in (alpha, alpha 'gamma) coincidence experiments

    NARCIS (Netherlands)

    Savran, D.; Babilon, M.; van den Berg, A. M.; Harakeh, M. N.; Hasper, J.; Wortche, H. J.; Zilges, A.


    We report on first results from experiments using the (alpha, alpha'gamma) reaction at E alpha = 136 MeV to investigate bound electric dipole (El) excitations building the so-called Pygmy Dipole Resonance (PDR) in the semi-magic nucleus Ce-140. The method of (alpha, alpha'gamma) allows the separatio

  10. Alpha-nucleus potential for alpha-decay and sub-barrier fusion

    CERN Document Server

    Denisov, V Y


    The set of parameters for alpha-nucleus potential is derived by using the data for both the alpha-decay half-lives and the fusion cross-sections around the barrier for reactions alpha+40Ca, alpha+59Co, alpha+208Pb. The alpha-decay half-lives are obtained in the framework of a cluster model using the WKB approximation. The evaluated alpha-decay half-lives and the fusion cross-sections agreed well with the data. Fusion reactions between alpha-particle and heavy nuclei can be used for both the formation of very heavy nuclei and spectroscopic studies of the formed compound nuclei.

  11. Alpha-nucleus potential for alpha-decay and sub-barrier fusion


    Denisov, V. Yu.; Ikezoe, H.


    The set of parameters for alpha-nucleus potential is derived by using the data for both the alpha-decay half-lives and the fusion cross-sections around the barrier for reactions alpha+40Ca, alpha+59Co, alpha+208Pb. The alpha-decay half-lives are obtained in the framework of a cluster model using the WKB approximation. The evaluated alpha-decay half-lives and the fusion cross-sections agreed well with the data. Fusion reactions between alpha-particle and heavy nuclei can be used for both the f...

  12. Synthesis of a peroxime proliferator activated receptor (PPAR) alpha/gamma agonist via stereocontrolled Williamson ether synthesis and stereospecific SN2 reaction of S-2-chloro propionic acid with phenoxides. (United States)

    Aikins, James A; Haurez, Michael; Rizzo, John R; Van Hoeck, Jean-Pierre; Brione, Willy; Kestemont, Jean-Paul; Stevens, Christophe; Lemair, Xavier; Stephenson, Gregory A; Marlot, Eric; Forst, Mindy; Houpis, Ioannis N


    The stereospecific synthesis of the PPAR alpha/gamma agonist 1 was accomplished via ethylation of the optically pure trihydroxy derivative 6, itself derived via an enzymatic resolution. The ethylation can be accomplished without epimerization only under strict control of the reaction conditions and the choice of base (sodium tert-amylate), temperature (-30 degrees C), order of addition, and solvent (DMF). The key diastereospecific SN2 reaction of the phenol 4 with S-2-chloropropionic acid is best achieved via the sodium phenoxide of 4 derived from Na0 as the reagent of choice. The structure elucidation and key purification protocols to achieve pharmaceutical purity will also be described.

  13. The Branchings of the Main s-process: Their Sensitivity to alpha-induced Reactions on 13C and 22Ne and to the Uncertainties of the Nuclear Network

    CERN Document Server

    Bisterzo, Sara; Kaeppeler, Franz; Wiescher, Michael; Imbriani, Gianluca; Straniero, Oscar; Cristallo, Sergio; Goerres, Joachim; deBoer, Richard


    This paper provides a detailed analysis of the main component of the slow neutron capture process (the s-process), which accounts for the solar abundances of half of the nuclei with 90 <~ A <~ 208. We examine the impact of the uncertainties of the two neutron sources operating in low-mass asymptotic giant branch (AGB) stars: the 13C(alpha, n)16O reaction, which releases neutrons radiatively during interpulse periods (kT ~ 8 keV), and the 22Ne(alpha, n)25Mg reaction, partially activated during the convective thermal pulses (TPs). We focus our attention on the branching points that mainly influence the abundance of s-only isotopes. In our AGB models, the 13C is fully consumed radiatively during interpulse. In this case, we find that the present uncertainty associated to the 13C(alpha, n)16O reaction has marginal effects on s-only nuclei. On the other hand, a reduction of this rate may increase the amount of residual (or unburned) 13C at the end of the interpulse: in this condition, the residual 13C is bur...

  14. Cross sections for the /sup 14/N(n,p/sub 0/), (n,. cap alpha. /sub 0/), and (n,. cap alpha. /sub 1/) reactions from 0. 5 to 15 MeV. [0. 5 to 15 MeV, tables, diagrams

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, G.L.


    Cross sections were measured for the /sup 14/N(n,p/sub 0/) reaction from 0.5 to 7.0 MeV and for the (n,..cap alpha../sub 0/) and (n,..cap alpha../sub 1/) reactions from 1 to 15 MeV and 4 to 15 MeV, respectively. The data were obtained using a gaseous scintillator containing N/sub 2/ and Xe mixtures. A linac was used as a pulsed, white neutron source with a 29-m flight path. The results of the measurement are compared to the current evaluated file for nitrogen; agreement is good for neutron energies below 8 MeV, but the measurement is substantially higher than the evaluation for neutron energies near 10 MeV. 28 references.

  15. Efficient one-pot enzymatic synthesis of alpha-(1 -> 4)-glucosidic disaccharides through a coupled reaction catalysed by Lactobacillus acidophilus NCFM maltose phosphorylase

    DEFF Research Database (Denmark)

    Nakai, Hiroyuki; Dilokpimol, Adiphol; Abou Hachem, Maher


    -b-glucopyranosyl( 1 -> 4)-o-glucosaminopyranose I maltosaminej, a-a-glucopyranosyl-(1 -> 4)-b-mannopyranose, alpha-n-glucopyranosyl-(1 -> 4)-t-fucopyranose and alpha-b-glucopyranosyl-(1 -> 4)-D-xylopyranose, respectively, from 0 1 M maltose, 0.5 M N-acetyl glucosamine, 0.1 M glucosamine. 0.1 M mannose, 1 M t-fucose...

  16. Measurement of the astrophysical S-factor for the {sup 18}F(p,{alpha}) reaction at E = 662 keV/u with a {sup 18}F radioactive beam

    Energy Technology Data Exchange (ETDEWEB)

    Rehm, K.E.; Blumenthal, D.J.; Gehring, J. [and others


    {sup 18}F is produced in stars during the so-called breakout from the hot CNO cycle and is important as one of the links connecting the HCNO cycle with the rp-process by producing {sup 19}Ne via the {sup 18}F(p,{gamma}) reaction. There is, however, a competing reaction {sup 18}F(p,{alpha}){sup 15}O which leads back into the CNO cycle. The importance of {sup 18}F for producing {sup 19}Ne therefore depends strongly on the (p,{gamma}) to (p,{alpha}) cross sections ratio. We have begun to study the {sup 18}F(p,{alpha}){sup 15}O reaction using a {sup 18}F beam. {sup 18}F, which is a well-studied PET isotope, is generated at the medical cyclotron of the University of Wisconsin. Aqueous [{sup 18}F] fluoride ions are produced via the {sup 18}O(p,n){sup 18}F reaction using a 30-{mu}A, 11.4-MeV proton beam bombarding a 95% enriched [{sup 18}O] water target and electroplated onto the end of a 3-mm diameter Al anode. After electroplating, the anodized Al is pressed into a copper cathode insert for the National Electrostatics Corporation SNICS ion source, transported to Argonne National Laboratory and installed in the ion source of the Tandem accelerator at ATLAS. With an activity at the end of the electroplating process of 530 mCi, the starting activity after 2 h, which is the time needed to transport and install the material in the SNICS source, was 250 mCi, corresponding to a total number of {sup 18}F atoms of 8.8 x 10{sup 13}.

  17. Vicarious nucleophilic substitution of hydrogen vs. ANRORC-type ring transformation in reactions of 1,2,4-triazines with alpha-halocarbanions. Novel route to functionalized pyrazoles

    NARCIS (Netherlands)

    Rykowski, A.; Wolinska, E.; Branowska, D.; Plas, van der H.C.


    A novel route to pyrazole derivatives bearing sulfonyl, aminosulfonyl, alkoxy- and aryloxysulfonyl groups at C-3 by ring transformation of 3-chloro-6-aryl-1,2,4-triazines 1a-c with alpha-halocarbanions 2a-h is described.

  18. High-spin states in /sup 79/Kr populated by the /sup 78/Se(. cap alpha. ,3n) reaction and interpreted in terms of a quasiparticle-plus-rotor model

    Energy Technology Data Exchange (ETDEWEB)

    Behar, M.; Filevich, A.; Macchiavelli, A.O.; Szybisz, L.; Thieberger, P.


    Nuclear states of /sup 79/Kr were studied through the /sup 78/Se(..cap alpha..,3n) reaction at an energy of 45 MeV. Excitation functions, ..gamma..-ray angular distributions and ..gamma..-..gamma.. coincidences were performed. Three bands based on the g.s. (1/2/sup -/), 147.1 keV (5/2/sup -/) and 129.7 keV (7/2/sup +/) states, were identified. Leading order analysis and quasiparticle-plus-rotor model calculations were performed. A good overall agreement was found between the experimental data and the theoretical predictions.

  19. Capture reactions

    NARCIS (Netherlands)

    Endt, P.M.


    Capture reactions will be considered here from the viewpoint of the nuclear spectroscopist. Especially important to him are the capture of neutrons, protons, and alpha particles, which may proceed through narrow resonances, offering a well defined initial state for the subsequent deexcitation proces

  20. Mono-thioesters and di-thioesters by lipase-catalyzed reactions of alpha,omega-alkanedithiols with palmitic acid or its methyl ester. (United States)

    Weber, N; Klein, E; Vosmann, K; Mukherjee, K D


    1- S-Mono-palmitoyl-hexanedithiol and 1- S-mono-palmitoyl-octanedithiol were prepared in high yield (80-90%) by solvent-free lipase-catalyzed thioesterification of palmitic acid with the corresponding alpha,omega-alkanedithiols in vacuo. Similarly, 1,6-di- S-palmitoyl-hexanedithiol and 1,8-di- S-palmitoyl-octanedithiol were prepared in moderate yield (50-60%) by solvent-free lipase-catalyzed thioesterification of palmitic acid with 1- S-Mono-palmitoyl-hexanedithiol and 1- S-mono-palmitoyl-octanedithiol, respectively. An immobilized lipase preparation from Rhizomucor miehei (Lipozyme RM IM) was more effective than a lipase B preparation from Candida antarctica (Novozym 435) or a lipase preparation from Thermomyces lanuginosus (Lipozyme TL IM). Lipase-catalyzed transthioesterifications of methyl palmitate with alpha,omega-alkanedithiols using the same enzymes were less effective than thioesterification for the preparation of the corresponding 1- S-mono-palmitoyl thioesters.

  1. Table of cross section (n,p), (n,{alpha}) and (n, 2n) reactions in steel components and other nuclear materials; Secciones eficaces (n, p), (n,{alpha}) y (n, 2n) de los componentes de los aceros y otros materiales nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Jimenez, J.


    Reactions (n,p) and (n, {alpha} ) produce in the materials large amount of hydrogen and helium atoms. The presence, specially of helium, changes the physical properties of materials and particularly reduce the ductility of irradiated stainless steel cladding above 500 degree centigree. Cross sections of all isotopes which constitute the S.S. and other clad materials, have been completed. Experimental available data were obtained from BNL (1956, 64 and 68), and the rest, from J.C, ROY and J . J . HAWTON calculations in a fission neutron spectrum (1960). (Author)

  2. Investigation of the thermal sup 2 sup 6 Al(n,p sub i) sup 2 sup 6 Mg and sup 2 sup 6 Al(n,alpha sub i) sup 2 sup 3 Na reactions

    CERN Document Server

    Wagemans, J; Goeminne, G; Geltenbort, P; Moens, A


    A homogeneous deposit of (2.58+-0.12)x10 sup 1 sup 7 sup 2 sup 6 Al atoms was produced applying the method of electrodeposition. With this target, the sup 2 sup 6 Al(n sub t sub h ,p sub i) sup 2 sup 6 Mg and the sup 2 sup 6 Al(n sub t sub h ,alpha sub i) sup 2 sup 3 Na reactions were studied at the high flux reactor of the ILL in Grenoble. Thermal cross section values for five transitions were obtained. The value for the sup 2 sup 6 Al(n sub t sub h , p sub 0) sup 2 sup 6 Mg cross section, (8.1+-0.8) mb, is a factor 3 lower than reported in the literature. For the sup 2 sup 6 Al(n sub t sub h , p sub 1) sup 2 sup 6 Mg cross section, a value of (1942+-95) mb was found, which is in reasonable agreement with the literature values. The result obtained for the sup 2 sup 6 Al(n sub t sub h , p sub 2) sup 2 sup 6 Mg cross section, (17+-4) mb, lies more than a factor 10 below the upper limit reported. A cross section value for the sup 2 sup 6 Al(n sub t sub h ,alpha sub 0) sup 2 sup 3 Na reaction of (261+-13) mb was...

  3. Constraining the 6.05 MeV 0$^+$ and 6.13 MeV 3$^-$ cascade transitions in the $^{12}$C($\\alpha$,$\\gamma$)$^{16}$O reaction using the Asymptotic Normalization Coefficients

    CERN Document Server

    Avila, M L; Koshchiy, E; Baby, L T; Belarge, J; Kemper, K W; Kuchera, A N; Mukhamedzhanov, A M; Santiago-Gonzalez, D; Uberseder, E


    Background. The $^{12}$C($\\alpha,\\gamma$)$^{16}$O reaction plays a fundamental role in astrophysics because its cross section near 300 keV in c.m. determines the $^{12}$C/$^{16}$O ratio at the end of the helium burning stage of stellar evolution. The astrophysically desired accuracy of better than 10\\% has not been achieved. Cascade $\\gamma$ transitions through the excited states of $^{16}$O are contributing to the uncertainty. Purpose. To measure the Asymptotic Normalization Coefficients (ANCs) for the 0$^+$ (6.05 MeV) and 3$^-$ (6.13 MeV) excited states in $^{16}$O and provide constraints on the cross section for the corresponding cascade transitions. Method. The ANCs were measured using the $\\alpha$-transfer reaction $^{12}$C($^6$Li,$d$)$^{16}$O performed at sub-Coulomb energies for both the entrance and exit channels. Results. The ANCs for the 0$^+$(6.05 MeV), 3$^-$(6.13 MeV), 2$^+$(6.92 MeV) and 1$^-$(7.12 MeV) states in $^{16}$O have been measured. The contribution of the 0$^+$ and 3$^-$ cascade transit...

  4. Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: Effect of the deciduoma reaction

    Directory of Open Access Journals (Sweden)

    Telleria Carlos M


    Full Text Available Abstract Background In the rat, the maintenance of gestation is dependent on progesterone production from the corpora lutea (CL, which are under the control of pituitary, decidual and placental hormones. The luteal metabolism of progesterone during gestation has been amply studied. However, the regulation of progesterone synthesis and degradation during pseudopregnancy (PSP, in which the CL are mainly under the control of pituitary prolactin (PRL, is not well known. The objectives of this investigation were: i to study the luteal metabolism of progesterone during PSP by measuring the activities of the enzymes 3beta-hydroxysteroid dehydrogenase (3betaHSD, involved in progesterone biosynthesis, and that of 20alpha-hydroxysteroid dehydrogenase (20alphaHSD, involved in progesterone catabolism; and ii to determine the role of decidualization on progesterone metabolism in PSP. Methods PSP was induced mechanically at 10:00 h on the estrus of 4-day cycling Wistar rats, and the stimulus for decidualization was provided by scratching the uterus on day 4 of PSP. 3betaHSD and 20alphaHSD activities were measured in the CL isolated from ovaries of PSP rats using a spectrophotometric method. Serum concentrations of progesterone, PRL, androstenedione, and estradiol were measured by radioimmunoassay (RIA. Results The PSP stage induced mechanically in cycling rats lasted 11.3 ± 0.09 days (n = 14. Serum progesterone concentration was high until day 10 of PSP, and declined thereafter. Serum PRL concentration was high on the first days of PSP but decreased significantly from days 6 to 9, having minimal values on days 10 and 11. Luteal 3betaHSD activities were elevated until day 6 of PSP, after which they progressively declined, reaching minimal values at the end of PSP. Luteal 20alphaHSD activities were very low until day 9, but abruptly increased at the end of PSP. When the deciduoma was induced by scratching the uterus of pseudopregnant animals on day 4 (PSP

  5. Study of function response of a detector HPGe to photons of reaction {sup 19}F(p,{alpha}{gamma}){sup 16}O; Estudo da funcao resposta de um detetor HPGe a fotons da reacao {sup 19}F(p,{alpha}{gamma}){sup 16}O

    Energy Technology Data Exchange (ETDEWEB)

    Tridapalli, D.B


    In the {sup 19}F(p,{alpha}{gamma}){sup 16}O reaction, characteristic gamma-rays with energies: 6.1 MeV; 6.9 MeV and 7.1 keV can be observed. These photons can be used in many important applications such as Proton Induced Gamma-ray Emission (PIGE), gamma radiography and calibration purposes. It has another advantage in calibration procedures, which is the observed photon flux is greater than other reactions studied, {sup 27}Al(p,{alpha}{gamma}){sup 28}Si and {sup 23}Na(p,{alpha}{gamma}){sup 24}Mg. In our laboratory, we are studying the efficiency and response function of HPGe detectors for high energy photons, and for this it is necessary a source with a level scheme with few gamma-ray transitions and known relative yields. The {sup 19}F(p,{alpha}{gamma}){sup 16}O reaction satisfies the first condition but in the literature we found relative yields for thick targets or reaction cross section for thin targets. However, we use targets of intermediate thickness, therefore in this work we measure the relative gamma-ray yields for protons with energies between 1.36 MeV and 1.42 MeV. The experiments were performed at the 1.7 MV Pelletron tandem accelerator of the Laboratorio de Analise de Materiais por Feixes Ionicos (LAMFI) located at Instituto de Fisica da Universidade de Sao Paulo, using a reverse-electrode closed-end coaxial HPGe detector with 72.5 mm in diameter and 60.5 mm in length, at 0 deg. The proton irradiation current was 50 nA, and the target consisted of 250 {mu}g/cm{sup 2} CaF{sub 2} evaporated on a 0.1 mm Ta backing. In this reaction the {sup 20}Ne resonant state fissions in flight, and the resulting {sup 16}O excited states have different half-lives; all observed peaks are deformed due to either Doppler broadening from {sup 16}O random velocity direction or Doppler shift from nuclei that leave the target toward the vacuum chamber. Moreover, the peak deformations vary with the proton energy. These deformations were modeled by a Monte Carlo simulation that

  6. Folding model study of the elastic $\\alpha + \\alpha$ scattering at low energies

    CERN Document Server

    Tan, Ngo Hai; Khoa, Dao T


    The folding model analysis of the elastic $\\alpha + \\alpha$ scattering at the incident energies below the reaction threshold of 34.7 MeV (in the lab system) has been done using the well-tested density dependent versions of the M3Y interaction and realistic choices for the $^4$He density. Because the absorption is negligible at the energies below the reaction threshold, we were able to probe the $\\alpha + \\alpha$ optical potential at low energies quite unambiguously and found that the $\\alpha + \\alpha$ overlap density used to construct the density dependence of the M3Y interaction is strongly distorted by the Pauli blocking. This result gives possible explanation of a long-standing inconsistency of the double-folding model in its study of the elastic $\\alpha + \\alpha$ and $\\alpha$-nucleus scattering at low energies using the same realistic density dependent M3Y interaction.

  7. Alpha fetoprotein (United States)

    Fetal alpha globulin; AFP ... Greater than normal levels of AFP may be due to: Cancer in testes , ovaries, biliary (liver secretion) tract, stomach, or pancreas Cirrhosis of the liver Liver cancer ...

  8. Desulfurization reactions on Ni2P(001) and alpha-Mo2C(001) surfaces: complex role of P and C sites. (United States)

    Liu, Ping; Rodriguez, José A; Asakura, Takeshi; Gomes, João; Nakamura, Kenichi


    X-ray photoelectron spectroscopy and first-principles density-functional calculations were used to study the interaction of thiophene, H(2)S, and S(2) with Ni(2)P(001), alpha-Mo(2)C(001), and polycrystalline MoC. In general, the reactivity of the surfaces increases following the sequence MoC P charge transfer) that allows a high activity for the dissociation of thiophene and molecular hydrogen. Second, the number of active Ni sites present in the surface decreases due to an "ensemble effect" of P, which prevents the system from deactivation induced by high coverages of strongly bound S. Third, the P sites are not simple spectators and provide moderate bonding to the products of the decomposition of thiophene and the H adatoms necessary for hydrogenation.

  9. Preparation of E-1,3-diaminoethenyl functional groups by the reaction of enol tosylate of alpha-formylglycine with primary and secondary amines

    Directory of Open Access Journals (Sweden)

    Sitaram Bhavaraju


    Full Text Available The E-1,3-diaminoethenyl functional group is a potentially useful synthon. A number of examples of E-1,3-diaminoethenyl functional groups were prepared in good yield starting from an E-enol tosylate of a serine based diketopiperazine and 1°- or 2° amine nucleophiles. The reaction proceeds via a stereoselective nucleophilic substitution pathway.

  10. Reactor neutron activation analysis for aluminium in the presence of phosphorus and silicon. Contributions of /sup 28/Al activities from /sup 31/P (n,. cap alpha. ) /sup 28/Al and /sup 28/Si (n,p) /sup 28/Al reactions

    Energy Technology Data Exchange (ETDEWEB)

    Mizumoto, Yoshihiko (Kinki Univ., Higashi-Osaka, Osaka (Japan). Faculty of Science and Technology); Iwata, Shiro; Sasajima, Kazuhisa; Yoshimasu, Fumio; Yase, Yoshiro


    Reactor neutron activation analysis for aluminium in samples containing phosphorus and silicon was studied. The experiments were performed by using pneumatic tube of the Kyoto University Reactor (KUR). At first, the ratios of the /sup 28/Al activity produced from /sup 27/Al(n, ..gamma..) /sup 28/Al reaction by thermal neutrons to that from /sup 31/P(n, ..cap alpha..)/sup 28/Al reaction by fast neutrons, and to that from /sup 28/Si(n, p)/sup 28/Al reaction were measured by ..gamma..-ray spectrometry. With a ratio of about 5 for the thermal to fast neutron flux of KUR, the ratio of the /sup 28/Al activity from aluminium to that from phosphorus was to be 812 +- 7, and to that from silicon 282 +- 3. Secondly, the contributions of /sup 28/Al activities from phosphorus and silicon and the determination limit of aluminium were calculated for various parameters, such as fast neutron flux, thermal to fast neutron flux ratio, amounts of phosphorus and silicon, etc. Thirdly, on the basis of these results, aluminium contents in spinal cords and brains of amyotrophic lateral sclerosis, Parkinsonism-dementia complex and control cases were determined.

  11. Studies of the mechanism of the cyclisation reaction catalysed by the wildtype and a truncated alpha-cyclodextrin glycosyltransferase from Klebsiella pneumoniae strain M 5 al, and the beta-cyclodextrin glycosyltransferase from Bacillus circulans strain 8. (United States)

    Bender, H


    The actions of the wildtype and a truncated alpha-cyclodextrin glycosyltransferase from Klebsiella pneumoniae strain M 5 al on malto-oligosaccharides showed no significant differences, and there was marked dependence of the kinetic parameters on the chain lengths of the substrate. The action of the beta-cyclodextrin glycosyltransferase from Bacillus circulans was less dependent on the chain length of the substrate, but Vmax of the initial cyclisation with the longer malto-oligosaccharides was only 28% of that determined for the enzyme of K. pneumoniae. The rate parameters suggested that the active site of each enzyme spans nine glucosyl residues, and that the catalytic sites are situated between subsites three and four for the K. pneumoniae enzymes and between subsites two and three for the B. circulans enzyme. The molecular binding affinities and the affinities of the 9th subsite were calculated from the rate parameters. The primary and tertiary structures of alpha-amylases and cyclodextrin glycosyltransferases are compared in the context of the reaction mechanism of the latter enzymes.

  12. Cross Sections for proton induced high energy $\\gamma$-ray emission (PIGE) in reaction $^{19}$F(p,$\\alpha\\gamma$)$^{16}$O at incident proton energies between 1.5 and 4 MeV

    CERN Document Server

    Cabanelas, P; Fonseca, M; Galaviz, D; Henriques, A; Jesus, A P; Luís, H; Sánchez-Benítez, A; Santos, C; Silva, H; Teubig, P; Velho, P


    We have studied the high energy gamma-rays produced in the reaction $^{19}$F(p,$\\alpha\\gamma$)$^{16}$O for incident proton energies from 1.5 to 4.0 MeV over NaF/Ag and CaF$_2$/Ag thin targets in two different sets of data. Gamma-rays were detected with a High Purity Ge detector with an angle of 130$^{o}$ with respect to the beam axis. The cross-sections for the high energy gamma-rays of 6.129, 6.915 and 7.115 MeV have been measured for the whole group between 5 and 7.2 MeV with accuracy better than 10%. A new energy range was covered and more points are included in the cross-sections data base. Results are in agreement with previous measurements in similar conditions.

  13. Clustering effect of {sup 12}C fragmentation in p+{sup 12}C, {alpha}+{sup 12}C and {sup 14}N+{sup 12}C reactions

    Energy Technology Data Exchange (ETDEWEB)

    Takemoto, Hiroki; Horiuchi, Hisashi [Kyoto Univ. (Japan). Dept. of Physics; Ono, Akira


    In general, self-conjugate 4n-nuclei have anomalous excited states with the excitation energy 10-15 MeV, which are recognized to be generated by the change of the structure from the shell-model-like one into the cluster one due to the activation of the clustering degrees of freedom. In AMD (Antisymmetrized Molecular Dynamics) fermic nature of nucleons is treated exactly, because the wave function of A-body system is antisymmetrized by a Slater determinant. Hence Pauli principle has been fully incorporated in AMD. As a result, it was concluded that the features of {sup 12}C fragmentation are originated from the activation of alpha-cluster degrees of freedom by indicating the excitation energy spectra of {sup 12}C before its breakup at the dynamical stage. Excitation energy spectrum before {sup 12}C breakup into any fragments consists of two components. One distributes in the range 7-15 MeV and the other in the range above 15 MeV. Accordingly, the features is related to those excited states excited states of {sup 12}C that is considered to have the cluster structure. (G.K.)

  14. Antioxidant-enzyme reaction to the oxidative stress due to alpha-cypermethrin, chlorpyriphos, and pirimicarb in tomato (Lycopersicon esculentum Mill.). (United States)

    Chahid, Karim; Laglaoui, Amin; Zantar, Said; Ennabili, Abdeslam


    Tomato (Lycopersicon esculentum Mill.) becomes one of the world's foremost vegetables, and its world production and consumption have increased fairly quickly. The capacity to induce oxidative stress in tomato plant, exposed to three xenobiotics such as alpha-cypermethrin, chlorpyriphos, and pirimicarb, was investigated by the evaluation of lipid peroxidation by measuring malondialdehyde (MDA) rate; also, we studied the response of tomato to this stress by assessing the response of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), ascorbate peroxidase (APX), glutathione-s-transferase (GST), and glutathione reductase (GR). The effect of the insecticides was observed using four concentrations (25, 50, 75, and 100%) for germinating seeds and only the recommended concentration in agriculture (100%) for growing plants. Our results show an important accumulation of MDA, demonstrating the increase of lipid peroxidation in consequence of the excessive reactive oxygen species (ROS) production due to insecticide treatment. In response to this oxidative stress in tomato seedlings and plants, the activities of antioxidant-enzyme system were generally enhanced. The electrophoretic analysis showed also the apparition of new isoenzymes as the case for CAT and POD.

  15. Synthesis of alpha-phosphorylated alpha,beta-unsaturated imines and their selective reduction to vinylogous and saturated alpha-aminophosphonates. (United States)

    Palacios, Francisco; Vicario, Javier; Maliszewska, Agnieszka; Aparicio, Domitila


    An efficient synthesis of alpha,beta-unsaturated imines derived from alpha-aminophosphonates is achieved through aza-Wittig reaction of P-trimethyl phosphazenes with beta,gamma-unsaturated alpha-ketophosphonates. Selective 1,2-reduction of such 1-azadienes affords beta,gamma-unsaturated alpha-aminophosphonates, phosphorylated analogs of vinylglycines, which are hydrogenated to yield saturated alpha-aminophosphonate derivatives.

  16. $\\alpha_s$ review (2016)

    CERN Document Server

    d'Enterria, David


    The current world-average of the strong coupling at the Z pole mass, $\\alpha_s(m^2_{Z}) = 0.1181 \\pm 0.0013$, is obtained from a comparison of perturbative QCD calculations computed, at least, at next-to-next-to-leading-order accuracy, to a set of 6 groups of experimental observables: (i) lattice QCD "data", (ii) $\\tau$ hadronic decays, (iii) proton structure functions, (iv) event shapes and jet rates in $e^+e^-$ collisions, (v) Z boson hadronic decays, and (vi) top-quark cross sections in p-p collisions. In addition, at least 8 other $\\alpha_s$ extractions, usually with a lower level of theoretical and/or experimental precision today, have been proposed: pion, $\\Upsilon$, W hadronic decays; soft and hard fragmentation functions; jets cross sections in pp, e-p and $\\gamma$-p collisions; and photon F$_2$ structure function in $\\gamma\\,\\gamma$ collisions. These 14 $\\alpha_s$ determinations are reviewed, and the perspectives of reduction of their present uncertainties are discussed.

  17. Involvement of metals in enzymatic and nonenzymatic decomposition of C-terminal alpha-hydroxyglycine to amide: an implication for the catalytic role of enzyme-bound zinc in the peptidylamidoglycolate lyase reaction. (United States)

    Takahashi, Kenichi; Harada, Saori; Higashimoto, Yuichiro; Shimokawa, Chizu; Sato, Hideaki; Sugishima, Masakazu; Kaida, Yasuhiko; Noguchi, Masato


    The peptide C-terminal amide group essential for the full biological activity of many peptide hormones is produced by consecutive actions of peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidylamidoglycolate lyase (PAL); PHM catalyzes the hydroxylation of C-terminal glycine, and PAL decomposes the peptidyl-alpha-hydroxyglycine to an amidated peptide and glyoxylate. PAL contains 1 mol of zinc, but its role, catalytic or structural, has not yet been clarified. In this study, we found that a series of transition metals, Mn(2+), Co(2+), Ni(2+), Cu(2+), Zn(2+), and Cd(2+), catalyze the nonenzymatic decomposition of the hydroxyglycine intermediate in a concentration-dependent manner. The second-order rate constant of the metal catalysis increased with elevation of pH, indicating that the hydrated metal acts as a general base. Extensive removal of the enzyme-bound metals remarkably diminished the PAL activity; k(cat) of the metal-depleted enzyme retaining 0.1 mol of zinc decreased to 3.2 s(-1) from 25.7 s(-1) of the wild-type enzyme. Among a series of divalent metals tested, Zn(2+), Co(2+), and Cd(2+) could fully restore the PAL activity of the metal-depleted enzyme. Especially, Zn substitution reproduced the steady-state parameters of the wild-type enzyme. On the other hand, Co and Cd substitution largely altered the kinetic parameters; the k(cat) increased 3- and 5-fold and the K(m) for the substrate increased 2.5- and 4-fold, respectively. These observations support that the enzyme-bound zinc plays a catalytic role, rather than a structural role, in the PAL reaction through the action of zinc-bound water as a general base.

  18. Ion-exchange separation of radioiodine and its application to production of {sup 124}I by alpha particle induced reactions on antimony

    Energy Technology Data Exchange (ETDEWEB)

    Shuza Uddin, Md. [Forschungszentrum Juelich (Germany). Inst. fuer Neurowissenschaften und Medizin, INM-5: Nuklearchemie; Atomic Energy Research Establishment, Inst. of Nuclear Science and Technology, Dhaka (Bangladesh); Qaim, Seyed M.; Spahn, Ingo; Spellerberg, Stefan; Scholten, Bernhard; Coenen, Heinz H. [Forschungszentrum Juelich (Germany). Inst. fuer Neurowissenschaften und Medizin, INM-5: Nuklearchemie; Hermanne, Alex [Vrije Univ. Brussel (Belgium). Cyclotron Lab.; Hossain, Syed Mohammod [Atomic Energy Research Establishment, Inst. of Nuclear Science and Technology, Dhaka (Bangladesh)


    The basic parameters related to radiochemical separation of iodine from tellurium and antimony by anion-exchange chromatography using the resin Amberlyst A26 were studied. The separation yield of {sup 124}I amounted to 96% and the decontamination factor from {sup 121}Te and {sup 122}Sb was > 10{sup 4}. The method was applied to the production of {sup 124}I via the {sup 123}Sb(α, 3n) reaction. In an irradiation of 110 mg of {sup nat}Sb{sub 2}O{sub 3} (thickness ∝0.08 g/cm{sup 2}) with 38 MeV α-particles at 1.2 μA beam current for 4 h, corresponding to the beam energy range of E{sub α} = 37 → 27 MeV, the batch yield of {sup 124}I obtained was 12.42 MBq and the {sup 125}I and {sup 126}I impurities amounted to 3.8% and 0.7%, respectively. The experimental batch yield of {sup 124}I amounted to 80% of the theoretically calculated value but the level of the radionuclidic impurities were in agreement with the theoretical values. About 96% of the radioiodine was in the form of iodide and the inactive impurities (Te, Sb, Sn) were below the permissible level. Due to the relatively high level of radionuclidic impurity the {sup 124}I produced would possibly be useful only for restricted local consumption or for animal experiments.

  19. {alpha}-nucleus potentials and photon-induced nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Galaviz, D. E-mail:; Babilon, M.; Fueloep, Zs.; Gyuerky, Gy.; Hillier, R.; Mate, Z.; Mohr, P.; Rauscher, T.; Somorjai, E.; Zilges, A.; Zolnai, L


    New data for the {sup 112,124}Sn({alpha},{alpha}){sup 112,124}Sn reaction have been measured and are presently analyzed. Results of the {sup 112} Sn x {alpha} potential at the energy E{sub c.m.} {approx} 14 MeV are presented. The determination of this {alpha}-nucleus potential may allow a prediction of the {sup 112}Sn({alpha},{gamma}){sup 116}Te cross section.

  20. Efficient synthesis of 1-azadienes derived from alpha-aminoesters. Regioselective preparation of alpha-dehydroamino acids, vinylglycines, and alpha-amino acids. (United States)

    Palacios, Francisco; Vicario, Javier; Aparicio, Domitila


    An efficient synthesis of 1-azadienes derived from alpha-aminoesters is achieved through an aza-Wittig reaction of phosphazenes with beta,gamma-unsaturated alpha-ketoesters. Regioselective 1,2-reduction of these functionalized 1-azadienes affords vinylglycine derivatives, while conjugative 1,4-reduction gives alpha-dehydroamino acid compounds. Reduction of both the carbon-carbon and the imine-carbon-nitrogen double bonds leads to the formation of alpha-amino acid derivatives.

  1. Cross sections for the formation of 195Hgm,g, 197Hgm,g, and 196Aum,g in alpha and 3He-particle induced reactions on Pt: Effect of level density parameters on the calculated isomeric cross-section ratio


    Sudár, S.; Qaim, S. M.


    Excitation functions were measured for the reactions Pt-nat(He-3,xn)Hg-195(m,g),Pt-nat(He-3,xn)Hg-197(m,g),Pt-nat(He-3,x)Au-196(m,g), and Pt-nat(alpha,xn)Hg-197(m,g) over the energy range of 18-35 MeV for He-3 particles and 17-26 MeV for alpha particles. The reactions Au-197(p,n)Hg-197(m,g) were also investigated over the proton energy range of 6-20 MeV. The three projectiles were produced at the Julich variable-energy compact cyclotron (CV 28). Use was made of the activation technique in com...

  2. Hyperresponsive febrile reactions to interleukin (IL) 1alpha and IL-1beta, and altered brain cytokine mRNA and serum cytokine levels, in IL-1beta-deficient mice. (United States)

    Alheim, K; Chai, Z; Fantuzzi, G; Hasanvan, H; Malinowsky, D; Di Santo, E; Ghezzi, P; Dinarello, C A; Bartfai, T


    IL-1beta is an endogenous pyrogen that is induced during systemic lipopolysaccharide (LPS)- or IL-1-induced fever. We have examined the fever and cytokine responses following i.p. injection of IL-1 agonists, IL-1alpha and IL-1beta, and compared these with response to LPS (i.p.) in wild-type and IL-1beta-deficient mice. The IL-1beta deficient mice appear to have elevated body temperature but exhibit a normal circadian temperature cycle. Exogenously injected IL-1beta, IL-1alpha, or LPS induced hyperresponsive fevers in the IL-1beta-deficient mice. We also observed phenotypic differences between wild-type and IL-1beta-deficient mice in hypothalamic basal mRNA levels for IL-1alpha and IL-6, but not for IL-1beta-converting enzyme or IL-1 receptor type I or type II. The IL-1alpha mRNA levels were down-regulated, whereas the IL-6 mRNA levels were up-regulated in the hypothalamus of IL-1beta-deficient mice as compared with wild-type mice. The IL-1beta-deficient mice also responded to LPS challenge with significantly higher serum corticosterone and with lower serum tumor necrosis factor type alpha levels than the wild-type mice. The data suggest that, in the redundant cascade of proinflammatory cytokines, IL-1beta plays an important but not obligatory role in fever induction by LPS or IL-1alpha, as well as in the induction of serum tumor necrosis factor type alpha and corticosterone responses either by LPS or by IL-1alpha or IL-1beta.

  3. Reactions with light exotic nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Lichtenthäler, R.; Faria, P.N. de; Pires, K.C.C.; Lepine-Szily, A.; Guimaraes, V.; Mendes Junior, D.R.; Assuncao, M.; Barioni, A.; Morcelle, V.; Morais, M.C.; Camargo Junior, O.; Alcantara Nuñez, J. [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Instituto de Fisica; Moro, A.M. [Departamento de FAMN, Universidad de Sevilla, Sevilla (Spain); Arazi, A. [Laboratorio Tandar, Departamento de Fisica, Comision Nacional de Energia Atomica (CNEA), Buenos Aires (Argentina); Rodriguez-Gallardo, M. [Instituto de Estructura de la Materia, CSIC, Madrid (Spain)


    Experimental cross sections for the {sup 6}He+{sup 120}Sn are analysed. Elastic scattering angular distributions and alpha particle production cross sections have been measured and are compared with the total reaction cross sections. (author)

  4. Ab initio alpha-alpha scattering

    CERN Document Server

    Elhatisari, Serdar; Rupak, Gautam; Epelbaum, Evgeny; Krebs, Hermann; Lähde, Timo A; Luu, Thomas; Meißner, Ulf-G


    Processes involving alpha particles and alpha-like nuclei comprise a major part of stellar nucleosynthesis and hypothesized mechanisms for thermonuclear supernovae. In an effort towards understanding alpha processes from first principles, we describe in this letter the first ab initio calculation of alpha-alpha scattering. We use lattice effective field theory to describe the low-energy interactions of nucleons and apply a technique called the adiabatic projection method to reduce the eight-body system to an effective two-cluster system. We find good agreement between lattice results and experimental phase shifts for S-wave and D-wave scattering. The computational scaling with particle number suggests that alpha processes involving heavier nuclei are also within reach in the near future.

  5. Dynamical Screening Effect on $\\alpha$-$\\alpha$ Resonant Scattering and Thermal Nuclear Scattering Rate

    CERN Document Server

    Yao, Xiaojun; Müller, Berndt


    We study the dynamical screening effect in the QED plasma on the $\\alpha$-$\\alpha$ scattering at the $^8$Be resonance. Dynamical screening leads to an imaginary part of the potential which results in a thermal width for the resonance and dominates over the previously considered static screening effect. As a result, both the resonance energy and width increase with the plasma temperature. Furthermore, dynamical screening can have a huge impact on the $\\alpha$-$\\alpha$ thermal nuclear scattering rate. For example, when the temperature is around $10$ keV, the rate is suppressed by a factor of about $900$. We expect similar thermal suppressions of nuclear reaction rates to occur in nuclear reactions dominated by an above threshold resonance with a thermal energy. Dynamical screening effects on nuclear reactions can be relevant to cosmology and astrophysics.

  6. Investigation of the Pygmy Dipole Resonance in ({alpha},{alpha}{sup '}{gamma}) coincidence experiments

    Energy Technology Data Exchange (ETDEWEB)

    Savran, D. [Institut fuer Kernphysik, TU Darmstadt, Schlossgartenstrasse 9, D-64289 Darmstadt (Germany); Babilon, M. [Institut fuer Kernphysik, TU Darmstadt, Schlossgartenstrasse 9, D-64289 Darmstadt (Germany); Berg, A.M. van den [Kernfysisch Versneller Instituut, Rijksuniversiteit Groningen, Zernikelaan 25, NL-9747 AA Groningen (Netherlands); Harakeh, M.N. [Kernfysisch Versneller Instituut, Rijksuniversiteit Groningen, Zernikelaan 25, NL-9747 AA Groningen (Netherlands); Hasper, J. [Institut fuer Kernphysik, TU Darmstadt, Schlossgartenstrasse 9, D-64289 Darmstadt (Germany); Woertche, H.J. [Kernfysisch Versneller Instituut, Rijksuniversiteit Groningen, Zernikelaan 25, NL-9747 AA Groningen (Netherlands); Zilges, A. [Institut fuer Kernphysik, TU Darmstadt, Schlossgartenstrasse 9, D-64289 Darmstadt (Germany)


    We report on first results from experiments using the ({alpha},{alpha}{sup '}{gamma}) reaction at E{sub {alpha}}=136 MeV to investigate bound electric dipole (E1) excitations building the so-called Pygmy Dipole Resonance (PDR) in the semi-magic nucleus {sup 140}Ce. The method of ({alpha},{alpha}{sup '}{gamma}) allows the separation of E1 excitations from states of higher multipolarity, provides an excellent energy resolution and therefore allows a detailed analysis for each single state. Studying bound E1 excitations in {alpha}-scattering experiments at intermediate energies becomes feasible for the first time even in nuclei with a high level density. The surprising results of the first experiment on {sup 140}Ce point to a splitting of the PDR in this nucleus.

  7. Faddeev calculation of 3 alpha and alpha alpha Lambda systems using alpha alpha resonating-group method kernel

    CERN Document Server

    Fujiwara, Y; Kohno, M; Suzuki, Y; Baye, D; Sparenberg, J M


    We carry out Faddeev calculations of three-alpha (3 alpha) and two-alpha plus Lambda (alpha alpha Lambda) systems, using two-cluster resonating-group method kernels. The input includes an effective two-nucleon force for the alpha alpha resonating-group method and a new effective Lambda N force for the Lambda alpha interaction. The latter force is a simple two-range Gaussian potential for each spin-singlet and triplet state, generated from the phase-shift behavior of the quark-model hyperon-nucleon interaction, fss2, by using an inversion method based on supersymmetric quantum mechanics. Owing to the exact treatment of the Pauli-forbidden states between the clusters, the present three-cluster Faddeev formalism can describe the mutually related, alpha alpha, 3 alpha and alpha alpha Lambda systems, in terms of a unique set of the baryon-baryon interactions. For the three-range Minnesota force which describes the alpha alpha phase shifts quite accurately, the ground-state and excitation energies of 9Be Lambda are...

  8. Nucleosynthesis by photon-induced reactions

    Energy Technology Data Exchange (ETDEWEB)

    Mohr, P. E-mail:; Babilon, M.; Galaviz, D.; Sonnabend, K.; Vogt, K.; Zilges, A


    Similar to the well-known Gamow window for charged particle induced reactions, there exists an effective energy window for photon-induced reactions. Properties of this window are discussed in detail for ({gamma}, n) and ({gamma}, {alpha}) reactions. These reactions are important for the nucleosynthesis of rare neutron-deficient p nuclei.

  9. Determination of {alpha}-nucleus potentials by {alpha}-elastic scattering and its implications for the {gamma}-process

    Energy Technology Data Exchange (ETDEWEB)

    Galaviz, D. E-mail:; Babilon, M.; Fueloep, Zs.; Gyuerky, Gy.; Mate, Z.; Hillier, R.; Mohr, P.; Rauscher, T.; Somorjai, E.; Zilges, A.; Zolnai, L


    Complete angular distributions for the reactions {sup 112,124}Sn({alpha},{alpha}){sup 112,124}Sn have been measured at different energies around the Coulomb barrier. Preliminary results for the {sup 112}Sn x {alpha} and {sup 124}Sn x {alpha} potentials at the energy E{sub c.m.} {approx} 19 MeV are presented. The full determination of the a-nucleus potential for both nuclides may also help to understand the behaviour of {alpha}-nucleus potentials along an isotopic chain.

  10. Multispecies pair annihilation reactions. (United States)

    Deloubrière, Olivier; Hilhorst, Henk J; Täuber, Uwe C


    We consider diffusion-limited reactions A(i)+A(j)--> (12 and d> or =2, we argue that the asymptotic density decay for such mutual annihilation processes with equal rates and initial densities is the same as for single-species pair annihilation A+A-->. In d=1, however, particle segregation occurs for all q< infinity. The total density decays according to a q dependent power law, rho(t) approximately t(-alpha(q)). Within a simplified version of the model alpha(q)=(q-1)/2q can be determined exactly. Our findings are supported through Monte Carlo simulations.


    NARCIS (Netherlands)



    Extended Huckel (EHT) calculations have been used to discuss the two alternative sigma-bond C-H metathesis reactions which occur with organo-lanthanide (Ln = Y, Lu) compounds. The two reactions lead either to H/H (H/D) exchange or to metalation and have been modelled by studying the interaction of a

  12. Reactions of a fluorescent ATP analog, 2'-(5-dimethyl-aminonaphthalene-1-sulfonyl) amino-2'-deoxyATP, with E. coli F1-ATPase and its subunits: the roles of the high affinity binding site in the alpha subunit and the low affinity binding site in the beta subunit. (United States)

    Matsuoka, I; Takeda, K; Futai, M; Tonomura, Y


    We performed kinetic studies on the reactions of a fluorescent ATP analog, 2'-(5-dimethyl-aminonaphthalene-1-sulfonyl) amino-2'-deoxyATP (DNS-ATP), with E. coli F1-ATPase (EF1) and its subunits, to clarify the role of each subunit in the ATPase reaction. The following results were obtained. 1. One mol of EF1, which contains nonexchangeable 2 mol ATP and 0.5 mol ADP, binds 3 mol of DNS-ATP. The apparent dissociation constant, in the presence of Mg2+, was 0.23 microM. Upon binding, the fluorescence intensity of DNS-ATP at 520 nm increased exponentially with t1/2 of 35 s, and reached 3.5 times the original fluorescence level. Following the fluorescence increase, DNS-ATP was hydrolyzed, and the fluorescence intensity maintained its enhanced level. 2. The addition of an excess of ATP over the EF1-DNS-nucleotide complex, in the presence of Mg2+, decreased the fluorescence intensity rapidly, indicating the acceleration of DNS-nucleotide release from EF1. ADP and GTP also decreased the fluorescence intensity. 3. DCCD markedly inhibited the accelerating effect of ATP on DNS-nucleotide release from EF1 and the EF1-DNS-ATPase or -ATPase activity in a steady state. On the other hand, DCCD only slightly inhibited the fluorescence increase of DNS-ATP, due to its binding to EF1, and the rate of single cleavage of 1 mol of DNS-ATP per mol of alpha subunit of EF1. 4. In the presence of Mg2+, 0.65-0.82 mol of DNS-ATP binds to 1 mol of the isolated alpha subunit of EF1 with an apparent dissociation constant of 0.06-0.07 microM. Upon binding, the fluorescence intensity of DNS-ATP at 520 nm increased 1.55 fold very rapidly (t1/2 less than 1 s). No hydrolysis of DNS-ATP was observed upon the addition of the isolated alpha subunit. The fluorescence intensity of DNS-ATP was unaffected by the addition of the isolated beta subunit. DNS-ATP was also unhydrolyzed by the isolated beta subunit. 5. EF1-ATPase was reconstituted from alpha, beta, and gamma subunits in the presence of Mg2+ and ATP

  13. The determination of $\\alpha_s$ by the ALPHA collaboration

    CERN Document Server

    Bruno, Mattia; Fritzsch, Patrick; Korzec, Tomasz; Ramos, Alberto; Schaefer, Stefan; Simma, Hubert; Sint, Stefan; Sommer, Rainer


    We review the ALPHA collaboration strategy for obtaining the QCD coupling at high scale. In the three-flavor effective theory it avoids the use of perturbation theory at $\\alpha > 0.2$ and at the same time has the physical scales small compared to the cutoff $1/a$ in all stages of the computation. The result $\\Lambda_\\overline{MS}^{(3)}=332(14)$~MeV is translated to $\\alpha_\\overline{MS}(m_Z)=0.1179(10)(2)$ by use of (high order) perturbative relations between the effective theory couplings at the charm and beauty quark "thresholds". The error of this perturbative step is discussed and estimated as $0.0002$.

  14. Determination of thin layer thickness from alpha particle energy spectra

    Energy Technology Data Exchange (ETDEWEB)

    Hnatowicz, V.; Kvitek, J. (Ceskoslovenska Akademie Ved, Prague. Ustav pro Elektrotechniku); Rybka, V.; Krejci, P. (Tesla, Prague (Czechoslovakia). Vyzkumny Ustav pro Sdelovaci Techniku); Pelikan, L. (Ceske Vysoke Uceni Technicke, Prague (Czechoslovakia). Fakulta Elektrotechnicka); Mikusik, P. (Ceskoslovenska Akademie Ved, Prague. Ustav Fyzikalni Chemie a Elektrochemie J. Heyrovskeho)


    A method which uses alpha particles from the /sup 10/B(n,alpha)/sup 7/Li nuclear reaction for the determination of surface layer thicknesses is described and experimentally checked. The thickness measurements can be performed on samples implanted with boron.

  15. Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues. (United States)

    Eason, M G; Liggett, S B


    At present, molecular cloning and pharmacological studies have delineated three human alpha 2-adrenergic receptor (alpha 2AR) subtypes, alpha 2C10, alpha 2C4, and alpha 2C2. Assignment of the alpha 2AR subtypes to specific functions has been limited by an unclear definition of tissue alpha 2AR expression outside of the central nervous system. It has been suggested that alpha 2C4 expression is confined to the brain, that alpha 2C2 expression is only in the liver and kidney, and that there is nearly ubiquitous expression of alpha 2C10. However, this is based on studies of a limited number of rat tissues or on studies using non-species-specific approaches. Therefore, to define alpha 2C10, alpha 2C4, and alpha 2C2 tissue expression, we used reverse transcription of total RNA isolated from 20 human tissues, followed by amplification of alpha 2AR cDNA using the polymerase chain reaction. This technique provided two advantages: high sensitivity and, with the use of subtype-specific oligonucleotide primers and probes, differentiation between the alpha 2AR subtypes. The tissues studied were aorta, vena cava, heart (epicardium and endocardium), lung, skeletal muscle, liver, pancreas (head and tail), fat (perinephric and subcutaneous), kidney (cortex and medulla), prostate, stomach, ileum, jejunum, colon, adrenal gland, and spleen. We found that the majority of these tissues expressed alpha 2C10, with the exceptions being the head of the pancreas, subcutaneous fat, colon, and spleen. In marked distinction to other studies, however, we found a prolific expression of the alpha 2C4 and alpha 2C2 subtypes. Expression of alpha 2C4 was found in all tissues with the exception of liver, fat, stomach, and colon, and a virtually ubiquitous expression of alpha 2C2 was found, with the exception of epicardium. Of all tissues studied, only colon and subcutaneous fat expressed a single alpha 2AR subtype, which was alpha 2C2. Thus, the alpha 2AR subtypes do not have a confined expression but

  16. New ALPHA-2 magnet

    CERN Multimedia

    Anaïs Schaeffer


    On 21 June, members of the ALPHA collaboration celebrated the handover of the first solenoid designed for the ALPHA-2 experiment. The magnet has since been successfully installed and is working well.   Khalid Mansoor, Sumera Yamin and Jeffrey Hangst in front of the new ALPHA-2 solenoid. “This was the first of three identical solenoids that will be installed between now and September, as the rest of the ALPHA-2 device is installed and commissioned,” explains ALPHA spokesperson Jeffrey Hangst. “These magnets are designed to allow us to transfer particles - antiprotons, electrons and positrons - between various parts of the new ALPHA-2 device by controlling the transverse size of the particle bunch that is being transferred.” Sumera Yamin and Khalid Mansoor, two Pakistani scientists from the National Centre for Physics in Islamabad, came to CERN in February specifically to design and manufacture these magnets. “We had the chance to work on act...

  17. Lyman Alpha Control

    CERN Document Server

    Nielsen, Daniel Stefaniak


    This document gives an overview of how to operate the Lyman Alpha Control application written in LabVIEW along with things to watch out for. Overview of the LabVIEW code itself as well as the physical wiring of and connections from/to the NI PCI-6229 DAQ box is also included. The Lyman Alpha Control application is the interface between the ALPHA sequencer and the HighFinesse Wavelength Meter as well as the Lyman Alpha laser setup. The application measures the wavelength of the output light from the Lyman Alpha cavity through the Wavelength Meter. The application can use the Wavelength Meter’s PID capabilities to stabilize the Lyman Alpha laser output as well as switch between up to three frequencies.

  18. Synthesis of 4-amino-5-H-2,3-dihydroisothiazole-1,1-dioxide ring systems on sugar templates via carbanion-mediated sulfonamide intramolecular cyclization reactions (CSIC protocols) of glyco-alpha-sulfonamidonitriles. (United States)

    Domínguez, Laura; van Nhien, Albert Nguyen; Tomassi, Cyrille; Len, Christophe; Postel, Denis; Marco-Contelles, José


    The carbanion-mediated sulfonate intramolecular cyclizations (CSIC protocols) of glyco-alpha-sulfonamidonitriles derived from readily available monosaccharides have been extensively investigated using potassium carbonate, cesium carbonate, n-BuLi, and LDA as bases. As a result, a series of enantiomerically pure spiro(4-amino-5-H-2,3-dihydroisothiazole-1,1-dioxide) derivatives have been prepared efficiently and isolated in good yield. The synthesis of these new bicyclic systems is key to accessing a novel range of aza analogues of TSAO nucleosides (ATSAOs).

  19. Interpreting EEG alpha activity. (United States)

    Bazanova, O M; Vernon, D


    Exploring EEG alpha oscillations has generated considerable interest, in particular with regards to the role they play in cognitive, psychomotor, psycho-emotional and physiological aspects of human life. However, there is no clearly agreed upon definition of what constitutes 'alpha activity' or which of the many indices should be used to characterize it. To address these issues this review attempts to delineate EEG alpha-activity, its physical, molecular and morphological nature, and examine the following indices: (1) the individual alpha peak frequency; (2) activation magnitude, as measured by alpha amplitude suppression across the individual alpha bandwidth in response to eyes opening, and (3) alpha "auto-rhythmicity" indices: which include intra-spindle amplitude variability, spindle length and steepness. Throughout, the article offers a number of suggestions regarding the mechanism(s) of alpha activity related to inter and intra-individual variability. In addition, it provides some insights into the various psychophysiological indices of alpha activity and highlights their role in optimal functioning and behavior.

  20. Alpha Shapes and Proteins

    DEFF Research Database (Denmark)

    Winter, Pawel; Sterner, Henrik; Sterner, Peter


    We provide a unified description of (weighted) alpha shapes, beta shapes and the corresponding simplicialcomplexes. We discuss their applicability to various protein-related problems. We also discuss filtrations of alpha shapes and touch upon related persistence issues.We claim that the full...... potential of alpha-shapes and related geometrical constructs in protein-related problems yet remains to be realized and verified. We suggest parallel algorithms for (weighted) alpha shapes, and we argue that future use of filtrations and kinetic variants for larger proteins will need such implementation....

  1. A twin ionization chamber setup as detector for light charged particles with energies around 1 MeV applied to the sup 1 sup 0 B(n, alpha) sup 7 Li reaction

    CERN Document Server

    Göpfert, A; Bax, H


    The setup and operating conditions of a gridded twin ionization chamber with sample change facility to study light charged particle properties in the 1 MeV region is described. Detailed studies of different grid geometries in connection with the choice of an eligible counting gas mixture and the applied high voltage have been performed. Due to the high overall amplification of the small electrical chamber signals obtained from such low-energy particles, special filters have been developed in order to increase the signal-to-noise ratio. Timing properties of the chamber signals are discussed in detail. Information available from chamber signals and encoding methods are elucidated by spectra of alpha particles created by sup 2 sup 3 sup 4 sup , sup 2 sup 3 sup 5 U spontaneous alpha decay. The detector permits the independent and simultaneous measurement of energy and angular distribution of particles in both sides of the chamber. Finally, preliminary results and related analysis methods will be presented for the...

  2. $\\alpha$-cluster ANCs for nuclear astrophysics

    CERN Document Server

    Avila, M L; Koshchiy, E; Baby, L T; Belarge, J; Kemper, K W; Kuchera, A N; Santiago-Gonzalez, D


    Background. Many important $\\alpha$-particle induced reactions for nuclear astrophysics may only be measured using indirect techniques due to small cross sections at the energy of interest. One of such indirect technique, is to determine the Asymptotic Normalization Coefficients (ANC) for near threshold resonances extracted from sub-Coulomb $\\alpha$-transfer reactions. This approach provides a very valuable tool for studies of astrophysically important reaction rates since the results are practically model independent. However, the validity of the method has not been directly verified. Purpose. The aim of this letter is to verify the technique using the $^{16}$O($^6$Li,$d$)$^{20}$Ne reaction as a benchmark. The $^{20}$Ne nucleus has a well known $1^-$ state at excitation energy of 5.79 MeV with a width of 28 eV. Reproducing the known value with this technique is an ideal opportunity to verify the method. Method. The 1$^-$ state at 5.79 MeV is studied using the $\\alpha$-transfer reaction $^{16}$O($^6$Li,$d$)$^...


    NARCIS (Netherlands)

    DENDOOVEN, PG; DRAKE, RP; CABLE, MD; Dendooven, Peter


    For large inertial confinement fusion deuterium-tritium targets, a way to diagnose alpha slowing might be via capture reaction gamma rays. Calculations are presented for two such methods: one uses the alpha+T direct capture gamma rays, the other is based on a series of resonant alpha-capture reactio

  4. Buffett’s Alpha

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Kabiller, David; Heje Pedersen, Lasse

    Berkshire Hathaway has realized a Sharpe ratio of 0.76, higher than any other stock or mutual fund with a history of more than 30 years, and Berkshire has a significant alpha to traditional risk factors. However, we find that the alpha becomes insignificant when controlling for exposures to Betting...

  5. Optimization of Inhibitory Reaction System of Folium Mori Extracts on Alpha-glucosidase Activity and Enzyme Kinetics%桑叶提取物抑制α-葡萄糖苷酶活性体系的优化及动力学研究

    Institute of Scientific and Technical Information of China (English)

    吕欢; 罗明琍; 方飞; 吴新荣


    Objective To establish an optimized inhibitory reaction system for the research of Folium Mori extracts in inhibiting alpha-glucosidase activity and to investigate the enzyme kinetics. Methods We studied the inhibitive effects of Folium Mori extracts on alpha-glucosidase by using enzyme-inhibitor model and optimized the reaction system by optimizing the substrate concentration, the amount of enzyme and the reaction time. We also investigated the inhibitory kinetic characteristics of extracts by using Lineweaver-Burk method. Results The optimized reaction system consisted of 40 mg/mL of the substrate concentration, 0.2 mL of enzyme and 25 min for reaction time. Inhibitory kinetic results indicated that the extracts were mixed competitive inhibitors, but the positive drug was noncompetitive inhibitor. Conclusion Folium Mori extracts have inhibitory effect on a- glucosidase activity, and the inhibitory type is in mixed competitive inhibition, which are expected to be used to develop as anti-diabetes drugs.%目的 研究桑叶提取物抑制α-葡萄糖苷酶活性反应体系的条件优化及酶动力学.方法 采用酶-抑制剂模型法,优化底物浓度、酶用量和反应时间,确定最佳反应体系,研究桑叶提取物对α-葡萄糖苷酶的抑制作用,并采用双倒数作图法研究桑叶提取物的酶抑制动力学特性.结果 当蔗糖浓度为40 mg/mL,酶用量为0.2mL(约1.6 U/mL),反应时间为25 min时为最佳反应体系;酶抑制动力学实验表明,桑叶提取物的抑制类型为混合型竞争性抑制,阳性对照为非竞争性抑制.结论 桑叶提取物对α-葡萄糖苷酶活性有抑制作用;桑叶提取物对α-葡萄糖苷酶抑制活性为混合性竞争性抑制,可以用于开发降糖药物.

  6. Laser assisted {alpha} decay

    Energy Technology Data Exchange (ETDEWEB)

    Castaneda Cortes, Hector Mauricio


    Excited or short-lived nuclei often decay by emitting alpha particles that are assumed to be preformed inside the nucleus and confined in the nuclear potential well. In this picture, {alpha} decay refers to the tunneling of the alpha particle through the potential barrier. In this thesis we investigate for the first time how strong laser fields can assist the tunneling of the alpha particle and thus influence the nuclear decay. Generally speaking, laser-assisted {alpha} decay can be described as laser-assisted tunneling of a quasistationary state, i.e, a slowly decaying state. Our theoretical treatment is developed starting from the complex trajectory formulation of the well-known strong-field approximation used to describe laser-induced ionization. We extend this formulation and develop a method to treat the decay of quasistationary states. The effect of both static and optical and X-ray monochromatic fields on the lifetimes and {alpha}-particle emission spectra are investigated for a number of {alpha}-emitting nuclei. We find that even at strong intensities, the laser-induced acceleration of the {alpha} decay is negligible, ranging from a relative modification in the decay rate of 10{sup -3} for static fields of electric field strengths of 10{sup 15} V/m, to 10{sup -8} for strong optical fields with intensities of 10{sup 22} W/cm{sup 2}, and to 10{sup -6} for strong X-ray fields with laser intensities around 10{sup 24} W/cm{sup 2}. However, the effect of the external field is visible in the spectrum of emitted alpha particles, leading in the case of optical fields even to rescattering phenomena for intensities approaching 6 x 10{sup 22} W/cm{sup 2}. The dynamics of the alpha particle in laser fields of intensities below the rescattering limit is investigated.

  7. Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme. (United States)

    Tittmann, Kai; Schröder, Kathrin; Golbik, Ralph; McCourt, Jennifer; Kaplun, Alexander; Duggleby, Ronald G; Barak, Ze'ev; Chipman, David M; Hübner, Gerhard


    Acetohydroxy acid synthases (AHAS) are thiamin diphosphate- (ThDP-) and FAD-dependent enzymes that catalyze the first common step of branched-chain amino acid biosynthesis in plants, bacteria, and fungi. Although the flavin cofactor is not chemically involved in the physiological reaction of AHAS, it has been shown to be essential for the structural integrity and activity of the enzyme. Here, we report that the enzyme-bound FAD in AHAS is reduced in the course of catalysis in a side reaction. The reduction of the enzyme-bound flavin during turnover of different substrates under aerobic and anaerobic conditions was characterized by stopped-flow kinetics using the intrinsic FAD absorbance. Reduction of enzyme-bound FAD proceeds with a net rate constant of k' = 0.2 s(-1) in the presence of oxygen and approximately 1 s(-1) under anaerobic conditions. No transient flavin radicals are detectable during the reduction process while time-resolved absorbance spectra are recorded. Reconstitution of the binary enzyme-FAD complex with the chemically synthesized intermediate 2-(hydroxyethyl)-ThDP also results in a reduction of the flavin. These data provide evidence for the first time that the key catalytic intermediate 2-(hydroxyethyl)-ThDP in the carbanionic/enamine form is not only subject to covalent addition of 2-keto acids and an oxygenase side reaction but also transfers electrons to the adjacent FAD in an intramolecular redox reaction yielding 2-acetyl-ThDP and reduced FAD. The detection of the electron transfer supports the idea of a common ancestor of acetohydroxy acid synthase and pyruvate oxidase, a homologous ThDP- and FAD-dependent enzyme that, in contrast to AHASs, catalyzes a reaction that relies on intercofactor electron transfer.

  8. Genetics Home Reference: alpha thalassemia (United States)

    ... Understand Genetics Home Health Conditions alpha thalassemia alpha thalassemia Enable Javascript to view the expand/collapse boxes. Download PDF Open All Close All Description Alpha thalassemia is a blood disorder that reduces the production ...

  9. (n, {alpha}) cross section measurement of light nuclei using gridded ionization chamber and gaseous sample

    Energy Technology Data Exchange (ETDEWEB)

    Sanami, Toshiya; Baba, Mamoru; Saito, Keiichiro; Ibara, Yasutaka; Yamazaki, Tetsuro; Sato, Jun; Hirakawa, Naohiro [Tohoku Univ., Sendai (Japan)


    We have developed a measuring method of (n, {alpha}) cross section by using gaseous sample in a gridded ionization chamber. In this study, we measured the {sup 12}C(n, {alpha}{sub 0}) and the {sup 16}O(n, {alpha}{sub 0}), (n, {alpha}{sub 123}) cross sections for En=11.5 and 12.8 MeV neutrons. We also deduced the {sup 12}C(n, x{alpha}) spectrum and analyzed the data by a kinematic calculation combined with the reaction data of the {sup 12}C(n, n`3{alpha}). (author)

  10. alpha_s from tau decays revisited

    CERN Document Server

    Boito, D; Golterman, M; Jamin, M; Maltman, K; Osborne, J; Peris, S


    Being a determination at low energies, the analysis of hadronic tau decay data provides a rather precise determination of the strong coupling alpha_s after evolving the result to M_Z. At such a level of precision, even small non-perturbative effects become relevant for the central value and error. While those effects had been taken into account in the framework of the operator product expansion, contributions going beyond it, so-called duality violations, have previously been neglected. The following investigation fills this gap through a finite-energy sum rule analysis of tau decay spectra from the OPAL experiment, including duality violations and performing a consistent fit of all appearing QCD parameters. The resulting values for alpha_s(M_tau) are 0.307(19) in fixed-order perturbation theory and 0.322(26) in contour-improved perturbation theory, which translates to the n_f=5 values 0.1169(25) and 0.1187(32) at M_Z, respectively.

  11. Alpha-1 Antitrypsin Deficiency (United States)

    ... by blood tests showing the low levels of alpha-1 antitrypsin and abnormal liver tests. Other tests such as ultrasound imaging or tests using specialized X-ray techniques may be necessary. A liver biopsy may ...

  12. Metathesis process for preparing an alpha, omega-functionalized olefin

    Energy Technology Data Exchange (ETDEWEB)

    Burdett, Kenneth A. (Midland, MI); Mokhtarzadeh, Morteza (Charleston, WV); Timmers, Francis J. (Midland, MI)


    A cross-metathesis process for preparing an .alpha.,.omega.-functionalized olefin, such as methyl 9-decenoate, and an .alpha.-olefin having three or more carbon atoms, such as 1-decene. The process involves contacting in a first reaction zone an .alpha.-functionalized internal olefin, such as methyl oleate, and an .alpha.-olefinic monomer having three or more carbon atoms, such as 1-decene, with a first metathesis catalyst to prepare an effluent stream containing the .alpha.,.omega.-functionalized olefin, such as methyl 9-decenoate, an unfunctionalized internal olefin, such as 9-octadecene, unconverted reactant olefins, and optionally, an .alpha.,.omega.-difunctionalized internal olefinic dimer, such as dimethyl 9-octadecen-1,18-dioate; separating said effluent streams; then contacting in a second reaction zone the unfunctionalized internal olefin with ethylene in the presence of a second metathesis catalyst to obtain a second product effluent containing the .alpha.-olefinic monomer having three or more carbon atoms; and cycling a portion of the .alpha.-olefinic monomer stream(s) to the first zone.

  13. AlphaACT (United States)


    CBR can be found in the world around us (e.g., a doctor’s diagnosis based on a prior patient case, a lawyer preparing arguments based on legal ... metaphors in decision research. Judgment & Decision Making, 3(3), 195-204. Payne, J., Bettman, J., & Johnson, E. (1993). The Adaptive Decision Maker...alphaact. com 64 AlphaACT HAZMAT User Guide 8.3 Changing Measurement Units AlphaACT HAZMAT lets you show distances in either metric or English

  14. ALPHA-2: the sequel

    CERN Multimedia

    Katarina Anthony


    While many experiments are methodically planning for intense works over the long shutdown, there is one experiment that is already working at full steam: ALPHA-2. Its final components arrived last month and will completely replace the previous ALPHA set-up. Unlike its predecessor, this next generation experiment has been specifically designed to measure the properties of antimatter.   The ALPHA team lower the new superconducting solenoid magnet into place. The ALPHA collaboration is working at full speed to complete the ALPHA-2 set-up for mid-November – this will give them a few weeks of running before the AD shutdown on 17 December. “We really want to get some experience with this device this year so that, if we need to make any changes, we will have time during the long shutdown in which to make them,” says Jeffrey Hangst, ALPHA spokesperson. “Rather than starting the 2014 run in the commissioning stage, we will be up and running from the get go.&...

  15. Cross section measurements of the sup 1 sup 0 sup 2 Pd(p, gamma) sup 1 sup 0 sup 3 Ag, sup 1 sup 1 sup 6 Sn(p, gamma) sup 1 sup 1 sup 7 Sb, and sup 1 sup 1 sup 2 Sn(alpha, gamma) sup 1 sup 1 sup 6 Te reactions relevant to the astrophysical rp- and gamma-processes

    CERN Document Server

    Oezkan, N; Boyd, R N; Cole, A L; Famiano, M; Gueray, R T; Howard, M; Sahin, L; Zach, J J; Haan, R D; Görres, J; Wiescher, M C; Islam, M S; Rauscher, T


    Total cross section measurements for the sup 1 sup 0 sup 2 Pd(p, gamma) sup 1 sup 0 sup 3 Ag and sup 1 sup 1 sup 6 Sn(p, gamma) sup 1 sup 1 sup 7 Sb reactions have been performed in the proton energy range 2.6 to 4.25 MeV, and for the sup 1 sup 1 sup 2 Sn(alpha, gamma) sup 1 sup 1 sup 6 Te reaction over the alpha beam energy range 7.0 to 10.5 MeV. An activation technique was used in which gamma rays from decays of the reaction products were detected off-line by two hyper-pure germanium detectors in a low background environment. Where possible, reaction rates are derived and the results compared to those of calculations generated by the NON-SMOKER and the MOST statistical model codes so as to judge their applicability for describing the cross sections needed for network calculations of nucleosynthesis in explosive astrophysical environments via the gamma- and rp-processes.

  16. Alpha methyldopa induced hepatotoxicity in pregnancy

    Directory of Open Access Journals (Sweden)

    Padmasri Ramalingappa


    Full Text Available We report a case of gestational hepatitis due to alpha-methyldopa and briefly review the literature on alpha-methyldopa-induced hepatotoxicity in pregnancy. A 32 year old woman, primigravida with 34 weeks of gestation with pre eclampsia, presented with symptoms of nausea, dark coloured urine and jaundice. She was on alpha methyldopa (Aldomet 250 mg thrice a day since the last five weeks. Laboratory investigations revealed raised bilirubin, serum aspartate transaminases and serum alanine transaminases. Platelets were normal. Peripheral smear did not show haemolysis. With the exclusion of viral, haemolytic and obstructive causes, drug induced jaundice was considered as a differential diagnosis. Alpha methyldopa was withdrawn and replaced with nifedipine for her pre eclampsia treatment. Her repeat bilirubin level done two weeks later showed a drop. She went into labour at 38 weeks and delivered vaginally. In postpartum follow up her liver tests returned to normal in two weeks, about six weeks after stopping methyldopa. Hepatotoxicity should be considered as one of the adverse drug reaction of alpha methyldopa. It is not possible at present to predict which patients will develop liver disease following the administration of this drug. An awareness of the possibility of methyldopa induced hepatotoxicity should be present in the clinician's mind and liver function tests should be done at regular intervals. The occasional occurrence of this harmful side effect is not a contraindication to the use of this antihypertensive agent. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 805-807

  17. Synthesis of new derivatives from 1,2{alpha},4{alpha},5-tetramethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one; Sintese de novos herbicidas derivados do 1,2{alpha},4{alpha},5-tetrametil-8-oxabiciclo[3.2.1]oct-6-en-3-ona

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Luiz Claudio de Almeida; Maltha, Celia Regina Alvares; Demuner, Antonio Jacinto; Filomeno, Claudinei Andrade [Vicosa Univ., MG (Brazil). Dept. de Quimica]. E-mail:; Silva, Antonio Alberto da [Vicosa Univ., MG (Brazil). Dept. de Fitotecnia


    In this paper we report the synthesis of biologically active compounds through a [3+4] cycloaddition reaction to produce the main frame structure, followed by several conventional transformations. The 1,2{alpha},4{alpha},5-tetramethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one (11) obtained from a [3+4] cycloaddition reaction was converted into 1,2{alpha},4{alpha},5-tetramethyl-6,7-exo-isopropylidenedioxi-8 -oxabicyclo[3.2.1]octan-3-one (13) in 46% yield. This was further converted into the alcohols 1,2{alpha},4{alpha},5-tetramethyl-6,7-exo-isopropylidenedioxi-8-oxabicyclo[3.2= .1]octan-3{alpha}-ol (14), 1,2{alpha},4{alpha},5-tetramethyl-6,7-exo-isopropylidenedioxi-8 -oxabicyclo[3.2.1]octan-3{beta}-ol (15), 1,2{alpha},4{alpha},5-tetramethyl-3-butyl-6,7-exo-isopropylidenedioxi-8-oxabic= yclo[3.2.1]octan-3 {alpha}-ol (17), 1,2{alpha},4{alpha},5-tetramethyl-3-hexyl-6,7-exo-isopropylidenedioxi-8-oxabic= yclo[3.2.1]octan-3 {alpha}-ol (18) and 1,2{alpha},4{alpha},5-tetramethyl-3-decyl-6,7-exo-isopropylidenedioxi-8-oxabic= yclo[3.2.1]octan-3 {alpha}-ol (19). Dehydration of 17, 18 and 19 with thionyl chloride in pyridine resulted in the alkenes 20, 21 and 22 in ca. 82% - 89% yields from starting alcohols. The herbicidal activity of the compounds synthesized was evaluated at a concentration of 100 {mu}g g{sup -1}. The most active compound was 21 causing 42,7% inhibition against Cucumis sativus L. (author)

  18. $^{110,116}$Cd($\\alpha,\\alpha$)$^{110,116}$Cd elastic scattering and systematic investigation of elastic $\\alpha$ scattering cross sections along the $Z$ = 48 isotopic and $N$ = 62 isotonic chains

    CERN Document Server

    Kiss, G G; Fülöp, Zs; Gyürky, Gy; Elekes, Z; Farkas, J; Somorjai, E; Yalcin, C; Galaviz, D; Güray, R T; Özkan, N; Görres, J


    The elastic scattering cross sections for the reactions $^{110,116}$Cd($\\alpha,\\alpha$)$^{110,116}$Cd at energies above and below the Coulomb barrier are presented to provide a sensitive test for the alpha-nucleus optical potential parameter sets. Additional constraints for the optical potential are taken from the analysis of elastic scattering excitation functions at backward angles which are available in literature. Moreover, the variation of the elastic alpha scattering cross sections along the $Z = 48$ isotopic and $N = 62$ isotonic chain is investigated by the study of the ratios of the of $^{106,110,116}$Cd($\\alpha,\\alpha$)$^{106,110,116}$Cd scattering cross sections at E$_{c.m.} \\approx$ 15.6 and 18.8 MeV and the ratio of the $^{110}$Cd($\\alpha,\\alpha$)$^{110}$Cd and $^{112}$Sn($\\alpha,\\alpha$)$^{112}$Sn reaction cross sections at E$_{c.m.} \\approx$ 18.8 MeV, respectively. These ratios are sensitive probes for the alpha-nucleus optical potential parameterizations. The potentials under study are a basic...

  19. alpha-thalassemia mutations in Khuzestan Province, Southwest Iran. (United States)

    Zandian, Khodamorad; Nateghi, Jamal; Keikhaie, Bijan; Pedram, Mohammad; Hafezi-Nejad, Nima; Hadavi, Valeh; Oberkanins, Christian; Azarkeivan, Azita; Law, Hai-Yang; Najmabadi, Hossein


    Although alpha-thalassemia (alpha-thal) is the most common hereditary hemoglobin (Hb) disorder in Iran, no comprehensive data are so far available on the prevalence of the disease in the province of Khuzestan in Southwest Iran. This study investigates the spectrum of alpha-thal mutations in this region. One hundred and twenty-one subjects from Khuzestan Province, Iran, were initially tested for the three most common Iranian alpha-thal mutations (- alpha3.7, -alpha4.2, and --MED) by gap-polymerase chain reaction (gap-PCR). Reverse hybridization test strips and DNA sequencing were used to identify additional alpha-globin mutations. A total of 131 mutated alpha-globin alleles were identified in these patients. Of the 13 mutations that were detected in Khuzestan Province, Iran, the - alpha3.7 single gene deletion was the most frequently identified variant, representing 62.6% of the total; we also observed significant numbers of individuals with compound heterozygous mutations. On the basis of our results, we strongly recommend screening for the most common mutations to improve the molecular diagnosis of anemia in this region.

  20. The predominantly nonhydrolytic action of alpha amylases on alpha-maltosyl fluoride. (United States)

    Okada, G; Genghof, D S; Hehre, E J


    Crystalline alpha amylases from a number of sources utilized alpha-maltosyl fluoride as a glycosyl donor and acceptor at high rates (approximately 10 to approximately 1550 mumol/min/mg of protein, for 30 mM substrate). All enzymes catalyzed conversion of this compound into maltooligosaccharides in preference to causing its hydrolysis. Maltotetraosyl flouride and maltooligosaccharides of d.p. 3 to 6+ accounted for 75--93% (by weight) of early reaction-products. At a late stage, the yield of maltooligosaccharides was 2--5 times that of maltose, with chains as long as 12 D-glucosyl residues formed by one amylase (from Asp. oryzae), which utilized alpha-maltosyl fluoride as a donor and as an acceptor at extremely high rates. These results indicate that alpha amylases have a substantial capacity for binding two molecules of this small substrate in a distinctive way, with the C--F glycosylic bond of one and the free C-4 hydroxyl group of the other located in the region of the enzyme's catalytic groups, therby favoring glycosylation of the suitably positioned acceptor over solvent water. Hydrolysis is assumed to prevail when only a single substrate molecule or segment binds to alpha amylase with a (1 linked to 4)-alpha-D-glucosidic linkage of glycosylic C--F bond positioned at the catalytic center. The present demonstration that glycosyl-transfer reactions can be dominantly expressed by alpha amylases, given an appropriate substrate, illustrates the inadequacy of the usual characterization of these enzymes as hydrolases that produce overwhelming hydrolysis of all substrates.

  1. Study of the (p,d/sup 3/He) reaction as a quasi-free reaction process

    Energy Technology Data Exchange (ETDEWEB)

    Cowley, A. A.; Roos, P. G.; Chant, N. S.; Woody, R. III; Holmgren, H. D.; Goldberg, D. A.


    The (p,d/sup 3/He) reaction on /sup 6/Li, /sup 7/Li, /sup 9/Be, and /sup 12/C has been investigated in conjunction with studies of the (p,p..cap alpha..) reaction on the same targets. Coincident data for all four targets were obtained at a bombarding energy of 100 MeV for numerous angle pairs in order to test the reaction mechanism. Comparisons of the (p,d/sup 3/He) data to both (p,p..cap alpha..) data and distorted wave impulse approximation calculations (DWIA) indicate a dominance of the direct quasi-free reaction process (p + alpha yields d + /sup 3/He). The absolute alpha-particle spectroscopic factors extracted using DWIA analysis are in agreement with the values obtained in the (p,p..cap alpha..) reaction.

  2. A function for filamentous alpha-smooth muscle actin: Retardation of motility in human breast fibroblasts

    DEFF Research Database (Denmark)

    Rønnov-Jessen, Lone; Petersen, Ole William


    Actins are known to comprise six mammalian isoforms of which beta- and gamma-nonmuscle actins are present in all cells, whereas alpha-smooth muscle (alpha-sm) actin is normally restricted to cells of the smooth muscle lineages. alpha-Sm actin has been found also to be expressed transiently...... reactions. Here, we show that the presence of alpha-sm actin is a signal for retardation of migratory behavior in fibroblasts. Comparison in a migration assay of fibroblast cell strains with and without alpha-sm actin revealed migratory restraint in alpha-sm actin-positive fibroblasts. Electroporation...... in certain nonmuscle cells, in particular fibroblasts, which are referred to as myofibroblasts. The functional significance of alpha-sm actin in fibroblasts is unknown. However, myofibroblasts appear to play a prominent role in stromal reaction in breast cancer, at the site of wound repair, and in fibrotic...

  3. Evidence for Alpha Receptors in the Human Ureter (United States)

    Madeb, Ralph; Knopf, Joy; Golijanin, Dragan; Bourne, Patricia; Erturk, Erdal


    An immunohistochemical and western blot expression analysis of human ureters was performed in order to characterize the alpha-1-adrenergic receptor distribution along the length of the human ureteral wall. Mapping the distribution will assist in understanding the potential role alpha -1-adrenergic receptors and their subtype density might have in the pathophysiology of ureteral colic and stone passage. Patients diagnosed with renal cancer or bladder cancer undergoing nephrectomy, nephroureterectomy, or cystectomy had ureteral specimens taken from the proximal, mid, distal and tunneled ureter. Tissues were processed for fresh frozen examination and fixed in formalin. None of the ureteral specimens were involved with cancer. Serial histologic sections and immunohistochemical studies were performed using antibodies specific for alpha-1-adrenergic receptor subtypes (alpha 1a, alpha 1b, alpha 1d). The sections were examined under a light microscope and scored as positive or negative. In order to validate and quantify the alpha receptor subtypes along the human ureter. Western blotting techniques were applied. Human ureter stained positively for alpha -1-adrenergic receptors. Immunostaining appeared red, with intense reaction in the smooth muscle of the ureter and endothelium of the neighboring blood vessels. There was differential expression between all the receptors with the highest staining for alpha-1D subtype. The highest protein expression for all three subtypes was in the renal pelvis and decreased with advancement along the ureter to the distal ureter. At the distal ureter, there was marked increase in expression as one progressed towards the ureteral orifice. The same pattern of protein expression was exhibited for all three alpha -1-adrenergic receptor subtypes. We provide preliminary evidence for the ability to detect and quantify the alpha-1-receptor subtypes along the human ureter which to the best of our knowledge has never been done with

  4. Comparative Analysis of Eubacterial DNA Polymerase Ⅲ Alpha Subunits

    Institute of Scientific and Technical Information of China (English)

    Xiao-Qian Zhao; Jian-Fei Hu; Jun Yu


    DNA polymerase Ⅲ is one of the five eubacterial DNA polymerases that is responsible for the replication of DNA duplex. Among the ten subunits of the DNA polymerase Ⅲ core enzyme, the alpha subunit catalyzes the reaction for polymerizing both DNA strands. In this study, we extracted genomic sequences of the alpha subunit from 159 sequenced eubacterial genomes, and carried out sequencebased phylogenetic and structural analyses. We found that all eubacterial genomes have one or more alpha subunits, which form either homodimers or heterodimers.Phylogenetic and domain structural analyses as well as copy number variations of the alpha subunit in each bacterium indicate the classification of alpha subunit into four basic groups: polC, dnaE1, dnaE2, and dnaE3. This classification is of essence in genome composition analysis. We also consolidated the naming convention to avoid further confusion in gene annotations.

  5. ALPHA MIS: Reference manual

    Energy Technology Data Exchange (ETDEWEB)

    Lovin, J.K.; Haese, R.L.; Heatherly, R.D.; Hughes, S.E.; Ishee, J.S.; Pratt, S.M.; Smith, D.W.


    ALPHA is a powerful and versatile management information system (MIS) initiated and sponsored and by the Finance and Business Management Division of Oak Ridge National Laboratory, who maintain and develop it in concert with the Business Systems Division for its Information Center. A general-purpose MIS, ALPHA allows users to access System 1022 and System 1032 databases to obtain and manage information. From a personal computer or a data terminal, Energy Systems employees can use ALPHA to control their own report reprocessing. Using four general commands (Database, Select, Sort, and Report) they can (1) choose a mainframe database, (2) define subsets within it, (3) sequentially order a subset by one or more variables, and (4) generate a report with their own or a canned format.

  6. AlphaSphere


    Place, A.; Lacey, L.; Mitchell, T.


    The AlphaSphere is an electronic musical instrument featuring a series of tactile, pressure sensitive touch pads arranged in a spherical form. It is designed to offer a new playing style, while allowing for the expressive real-time modulation of sound available in electronic-based music. It is also designed to be programmable, enabling the flexibility to map a series of different notational arrangements to the pad-based interface.\\ud \\ud The AlphaSphere functions as an HID, MIDI and OSC devic...

  7. Alpha Antihydrogen Experiment

    CERN Document Server

    Fujiwara, M C; Ashkezari, M D; Baquero-Ruiz, M; Bertsche, W; Bray, C C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Cesar, C L; Fajans, J; Friesen, T; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A J; Hydomako, R; Jonsell, S; Kurchaninov, L; Lambo, R; Madsen, N; Menary, S; Nolan, P; Olchanski, K; Olin, A; Povilus, A; Pusa, P; Robicheaux, F; Sarid, E; Silveira, D M; So, C; Storey, J W; Thompson, R I; van der Werf, D P; Wilding, D; Wurtele, J S; Yamazaki, Y


    ALPHA is an experiment at CERN, whose ultimate goal is to perform a precise test of CPT symmetry with trapped antihydrogen atoms. After reviewing the motivations, we discuss our recent progress toward the initial goal of stable trapping of antihydrogen, with some emphasis on particle detection techniques.

  8. Case Study - Alpha

    Directory of Open Access Journals (Sweden)

    Stephen Leybourne


    Full Text Available This case study was developed from an actual scenario by Dr. Steve Leybourne of Boston University.  The case documents the historical evolution of an organization, and has been used successfully in courses dealing with organizational and cultural change, and the utilization of ‘soft skills’ in project-based management. This is a short case, ideal for classroom use and discussion.  The issues are easily accessible to students, and there is a single wide ranging question that allows for the inclusion of many issues surrounding strategic decision-making, and behavioural and cultural change. Alpha was one of the earlier companies in the USA to invest in large, edge-of-town superstores, with plentiful free vehicle parking, selling food and related household products. Alpha was created in the 1950s as a subsidiary of a major publicly quoted retail group.  It started business by opening a string of very large discount stores in converted industrial and warehouse premises in the south of the United States. In the early days shoppers were offered a limited range of very competitively priced products. When Alpha went public in 1981 it was the fourth largest food retailer in the US, selling an ever-widening range of food and non-food products.  Its success continued to be based on high volume, low margins and good value for money, under the slogan of ‘Alpha Price.’

  9. Alpha-mannosidosis

    DEFF Research Database (Denmark)

    Borgwardt, Line; Stensland, Hilde Monica Frostad Riise; Olsen, Klaus Juul;


    of the three subgroups of genotype/subcellular localisation and the clinical and biochemical data were done to investigate the potential relationship between genotype and phenotype in alpha-mannosidosis. Statistical analyses were performed using the SPSS software. Analyses of covariance were performed...

  10. Producing a compound Nucleus via Inelastic Scattering: The 90Zr(alpha,alpha')90Zr* Case

    Energy Technology Data Exchange (ETDEWEB)

    Escher, J E; Dietrich, F S


    In a Surrogate reaction a compound nucleus is produced via a direct reaction (pickup, stripping, or inelastic scattering). For a proper application of the Surrogate approach it is necessary to predict the resulting angular momentum and parity distribution in the compound nucleus. A model for determining these distributions is developed for the case of inelastic alpha scattering off a spherical nucleus. The focus is on obtaining a first, simple description of the direct-reaction process that produces the compound nucleus and on providing the basis for a more complete treatment of the problem. The approximations employed in the present description are discussed and the extensions required for a more rigorous treatment of the problem are outlined. To illustrate the formalism, an application to {sup 90}Zr({alpha},{alpha}{prime}){sup 90}Zr* is presented.

  11. alpha-Amanitin induced apoptosis in primary cultured dog hepatocytes.

    Directory of Open Access Journals (Sweden)

    Adam Szelag


    Full Text Available Amatoxin poisoning is caused by mushroom species belonging to the genera Amanita, Galerina and Lepiota with the majority of lethal mushroom exposures attributable to Amanita phalloides. High mortality rate in intoxications with these mushrooms is principally a result of the acute liver failure following significant hepatocyte damage due to hepatocellular uptake of amatoxins. A wide variety of amatoxins have been isolated; however, alpha-amanitin (alpha-AMA appears to be the primary toxin. Studies in vitro and in vivo suggest that alpha-AMA does not only cause hepatocyte necrosis, but also may lead to apoptotic cell death. The objective of this study was to evaluate the complex hepatocyte apoptosis in alpha-AMA cytotoxicity. All experiments were performed on primary cultured canine hepatocytes. The cells were incubated for 12 h with alpha-AMA at a final concentration of 1, 5, 10 and 20 microM. Viability test (MTT assay, apoptosis evaluation (TUNEL reaction, detection of DNA laddering and electron microscopy were performed at 6 and 12 h of exposure to alpha-AMA. There was a clear correlation between hepatocyte viability, concentration of alpha-AMA and time of exposure to this toxin. The decline in cultured dog hepatocyte viability during the exposure to alpha-AMA is most likely preceded by enhanced cellular apoptosis. Our results demonstrate that apoptosis might contribute to pathogenesis of the severe liver injury in the course of amanitin intoxication, particularly during the early phase of poisoning.

  12. Synthesis of stabilized alpha-helical peptides. (United States)

    Bernal, Federico; Katz, Samuel G


    Stabilized alpha-helical (SAH) peptides are valuable laboratory tools to explore important protein-protein interactions. Whereas most peptides lose their secondary structure when isolated from the host protein, stapled peptides incorporate an all-hydrocarbon "staple" that reinforces their natural alpha-helical structure. Thus, stapled peptides retain their functional ability to bind their native protein targets and serve multiple experimental uses. First, they are useful for structural studies such as NMR or crystal structures that map and better define binding sites. Second, they can be used to identify small molecules that specifically target that interaction site. Third, stapled peptides can be used to test the importance of specific amino acid residues or posttranslational modifications to the binding. Fourth, they can serve as structurally competent bait to identify novel binding partners to specific alpha-helical motifs. In addition to markedly improved alpha-helicity, stapled peptides also display resistance to protease cleavage and enhanced cell permeability. Most importantly, they are useful for intracellular experiments that explore the functional consequences of blocking particular protein interactions. Because of their remarkable stability, stapled peptides can be applied to whole-animal, in vivo studies. Here we describe a protocol for the synthesis of a peptide that incorporates an all-hydrocarbon "staple" employing a ring-closing olefin metathesis reaction. With proper optimization, stapled peptides can be a fundamental, accurate laboratory tool in the modern chemical biologist's armory.

  13. Synthesis and evaluation of phytotoxic activity of {alpha}-Santonin derivatives; Sintese e avaliacao da atividade fitotoxica de derivados da {alpha}-Santonina

    Energy Technology Data Exchange (ETDEWEB)

    Alvarenga, Elson S.; Barbosa, Luiz C.A.; Saliba, William A.; Arantes, Francisco F.P.; Demuner, Antonio J. [Universidade Federal de Vicosa (UFV), MG (Brazil). Dept. de Quimica]. E-mail:; Silva, Antonio A. [Universidade Federal de Vicosa (UFV), MG (Brazil). Dept. de Fitotecnia


    Mixtures of {alpha}-Santonin and various solvents were irradiated by either high or low pressure mercury lamps. The photochemical reactions afforded lumisantonin (11) (76% in acetonitrile), (3 S,3a S,9{beta}S)-3,6,6-trimethyl-3,3a,4,5-tetrahydronafto[1,2-b]furan-2,7({eta}6,9{beta}{eta}) dione (12) (100% in acetonitrile), 10{alpha}-acetoxy-3-oxo-1,7{alpha}H{eta},6,11{alpha}a{eta}-guaia-4-en-6,12-oli= de (8) (26% in acetic acid), 10{alpha}-hydroxy-3-oxo-1,7{alpha}a{eta},6,11{alpha}{eta}-guaia-4-en-6,12-olid= e (10) (32%) and (E)-3-((3 S,3a S,7{alpha}S)-3-methyl-2-oxo-6-(propan-2-ylidene)hexahydrobenzofuran- 7 - (7{alpha}{eta})-ylidene)propanoic acid (9) (44%) (in water/ acetic acid 1:1, v/v). Lactone 12 was also prepared by irradiation of lumisantonin in diethyl ether. Lactones 8 and 10 were converted, respectively, into the 10 {alpha}-acetoxy-3{alpha}-hydroxy-1,7{alpha}H,6,11{alpha}H-guaia-4-en-6,12-olid= e (13) (87%) and 3a,10a-dihydroxy-1,7{alpha}H,6,11{alpha}H-guaia-4-en-6,12-olide (14) (75%) by sodium borohydride reduction. The effects of the compounds on the development of radicle of Sorghum bicolor and Cucumis sativus were evaluated. (author)

  14. HB Hillingdon [alpha46(CE4)Phe-->Val (alpha1 Or alpha2)]: a new alpha chain hemoglobin variant. (United States)

    Babb, Anna; Solaiman, Susannah; Green, Brian N; Mantio, Debbie; Patel, Ketan


    Routine antenatal hemoglobinopathy screening detected a new alpha chain variant that eluted with Hb A(2) on cation exchange high performance liquid chromatography (HPLC) in a lady of Sri Lankan origin who had normal hematological indices. The mutation was identified by electrospray ionization mass spectrometry (ESI-MS) as alpha46(CE4)Phe-->Val, inferring that the variant was due to a single base change at codon 46 (TTC>GTC) of the alpha1- or alpha2-globin genes.

  15. Measurements of 15.11-MeV gamma-ray flux produced in the reactions C-12(p, p')-C-12*(15.11 MeV) and O-16(p, p' alpha)-C-12*(15.11 MeV) (United States)

    Lapides, J. R.; Crannell, C. J.; Crannell, H.; Hornyak, W. F.; Seltzer, S. M.; Trombka, J. I.; Wall, N. S.


    The flux of 15.11 MeV gamma rays relative to the flux of 4.44 MeV gamma rays which are emitted from the corresponding states of C-12 are a sensitive measure of the spectrum of exciting particles in solar flares and other cosmic sources. Emission of 15.11 MeV gamma rays may result not only from the direct excitation of C-12 but also from the interaction O-16 (p,p' alpha) C-12* sup 15.11 MeV. Although the cross sections for the direct reaction was studied extensively, the cross section for the spallation interaction with O-16 is not reported in the literature. Preliminary measurements demonstrated the feasibility of measuring the production of 15.11 MeV gamma rays by proton interactions with O-16 using the University of Maryland cyclotron facility. For both carbon and oxygen targets the flux of 15.11 MeV gamma rays is being measured relative to the flux of 4.44 MeV gamma rays. The gamma ray emission from de-excitation of the giant dipole resonances is being measured.

  16. Chemical reactivity of {alpha}-isosaccharinic acid in heterogeneous alkaline systems

    Energy Technology Data Exchange (ETDEWEB)

    Glaus, M. A.; Loon, L. R. Van


    Cellulose degradation under alkaline conditions is of relevance for the mobility of many radionuclides in the near-field of a cementitious repository for radioactive waste, because metal-binding degradation products may be formed. Among these, {alpha}- isosaccharinic acid ({alpha}-ISA) is the strongest complexant. The prediction of the equilibrium concentration of {alpha}-ISA in cement pore water is therefore an important step in the assessment of the influence of cellulose degradation products on the speciation of radionuclides in such environments. The present report focuses on possible chemical transformation reactions of {alpha}-ISA in heterogeneous alkaline model systems containing either Ca(OH){sub 2} or crushed hardened cement paste. The transformation reactions were monitored by measuring the concentration of {alpha}-ISA by high performance anion exchange chromatography and the formation of reaction products by high performance ion exclusion chromatography. The overall loss of organic species from solution was monitored by measuring the concentration of non-purgeable organic carbon. The reactions were examined in diluted and compacted suspensions, at either 25 {sup o}C or 90 {sup o}C, and under anaerobic atmospheres obtained by various methods. It was found that {alpha}-ISA was transformed under all conditions tested to some extent. Reaction products, such as glycolate, formate, lactate and acetate, all compounds with less complexing strength than {alpha}-ISA, were detected. The amount of reaction products identified by the chromatographic technique applied was {approx} 50 % of the amount of {alpha}-ISA reacted. Sorption of {alpha}-ISA to Ca(OH){sub 2} contributed only to a minor extent to the loss of {alpha}-ISA from the solution phase. As the most important conclusion of the present work it was demonstrated that the presence of oxidising agents had a distinctive influence on the turnover of {alpha}-ISA. Under aerobic conditions {alpha}-ISA was

  17. $\\alpha$-Representation for QCD


    Tuan, Richard Hong


    An $\\alpha$-parameter representation is derived for gauge field theories.It involves, relative to a scalar field theory, only constants and derivatives with respect to the $\\alpha$-parameters. Simple rules are given to obtain the $\\alpha$-representation for a Feynman graph with an arbitrary number of loops in gauge theories in the Feynman gauge.

  18. Alpha and Beta Determinations

    CERN Document Server

    Dunietz, Isard


    Because the Bd -> J/psi Ks asymmetry determines only sin(2 beta), a discrete ambiguity in the true value of beta remains. This note reviews how the ambiguity can be removed. Extractions of the CKM angle alpha are discussed next. Some of the methods require very large data samples and will not be feasible in the near future. In the near future, semi-inclusive CP-violating searches could be undertaken, which are reviewed last.

  19. Combining Alphas via Bounded Regression

    Directory of Open Access Journals (Sweden)

    Zura Kakushadze


    Full Text Available We give an explicit algorithm and source code for combining alpha streams via bounded regression. In practical applications, typically, there is insufficient history to compute a sample covariance matrix (SCM for a large number of alphas. To compute alpha allocation weights, one then resorts to (weighted regression over SCM principal components. Regression often produces alpha weights with insufficient diversification and/or skewed distribution against, e.g., turnover. This can be rectified by imposing bounds on alpha weights within the regression procedure. Bounded regression can also be applied to stock and other asset portfolio construction. We discuss illustrative examples.

  20. Alpha decay of {sup 181}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Davids, C.N.; Henderson, D.J.; Hermann, R. [and others


    The {alpha}-decay energy of {sup 181}Pb was measured as 7211(10) keV and 7044(15). In the first study the isotope was produced in {sup 90}Zr bombardments of {sup 94}Mo and, after traversing a velocity filter, implanted in a position-sensitive Si detector; no half life for {sup 181}Pb was reported. In the second study the isotope was produced in {sup 40}Ca bombardments of {sup 144}Sm and transported to a position in front of a Si(Au) surface barrier detector with a fast He-gas-jet capillary system; an estimate of 50 ms was determined for the {sup 181}Pb half life. Recently we investigated {sup 181}Pb {alpha} decay at ATLAS as part of a survey experiment in which a l-pnA beam of 400-MeV {sup 92}Mo was used to irradiate targets of {sup 89}Y, {sup 90,92,94}Zr, and {sup 92}Mo to examine yields for one- and two-nucleon evaporation products from symmetric cold-fusion reactions. Recoiling nuclei of interest were passed through the Fragment Mass Analyzer and implanted in a double-sided silicon strip detector for {alpha}-particle assay. With the {sup 90}Zr target we observed a group at 7065(20) keV which was correlated with A = 181 recoils and had a half life of 45(20) ms. Our new results for {sup 181}Pb therefore agreed with those of the second study. There was no indication in the {sup 90}Zr + {sup 92}Mo data of the 7211(10)-keV {alpha} particles seen by Keller et al. The interested reader is referred to the 1993 atomic mass evaluation wherein the input {alpha}-decay energies and resultant masses of the light Pb isotopes (including {sup 181}Pb) are discussed.

  1. Orthopositronium lifetime. Analytic results in O ({alpha}) and O ({alpha}{sup 3} ln {alpha})

    Energy Technology Data Exchange (ETDEWEB)

    Kniehl, B.A.; Kotikov, A.V.; Veretin, O.L. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik


    We present the O({alpha}) and O({alpha}{sup 3}ln {alpha}) corrections to the total decay width of orthopositronium in closed analytic form, in terms of basic transcendental numbers, which can be evaluated numerically to arbitrary precision. (orig.)

  2. Experimental cross section of {sup 144}Sm({alpha},{gamma}){sup 148}Gd

    Energy Technology Data Exchange (ETDEWEB)

    Somorjai, E. [Atomki, Debrecen (Hungary); Fueloep, Zs. [Atomki, Debrecen (Hungary); Kiss, A.Z. [Atomki, Debrecen (Hungary); Rolfs, C. [Ruhr-Universitaet, Bochum (Germany); Trautvetter, H.-P. [Ruhr-Universitaet, Bochum (Germany); Greife, U. [Ruhr-Universitaet, Bochum (Germany); Junker, M. [Ruhr-Universitaet, Bochum (Germany); Arnould, M. [Universite Libre de Bruxelles, Bruxelles (Belgium); Rayet, M. [Universite Libre de Bruxelles, Bruxelles (Belgium); Oberhummer, H. [Technische Universitaet, Vienna (Austria)


    The cross section of the {sup 144}Sm({alpha},{gamma}){sup 148} Gd reaction has been measured in the bombarding energy range of 10.5-13.4 MeV, using activation method based on the off-line {alpha}-activity measurement of the {sup 148}Gd residual nucleus. The long measuring time of the alpha decay demanded the utilization of solid state nuclear track detectors (SSNTD). The first results are compared to the latest statistical model calculations. (orig.).

  3. Reaction Graph

    Institute of Scientific and Technical Information of China (English)



    The paper proposes reaction graphs as graphical representations of computational objects.A reaction graph is a directed graph with all its arrows and some of its nodes labeled.Computations are modled by graph rewriting of a simple nature.The basic rewriting rules embody the essence of both the communications among processes and cut-eliminations in proofs.Calculi of graphs are ideentified to give a formal and algebraic account of reaction graphs in the spirit of process algebra.With the help of the calculi,it is demonstrated that reaction graphs capture many interesting aspects of computations.

  4. A radioimmunoassay for alpha- and beta-gliadins. (United States)

    Ciclitira, P J; Lennox, E S


    1. A rapid, sensitive specific radioimmunoassay for alpha- and beta-gliadin has been developed using an antiserum raised in rabbits to A-gliadin, a component of alpha-gliadin. 2. The antigen used in the assay was alpha-gliadin labelled with 125I; antigen-antibody complexes were collected after adsorption to Staphylococcus aureus in suspension. 3. The sensitivity of the assay, as judged by competitive binding with unlabelled antigen, was 1 ng of alpha- or beta-gliadin, which show complete cross-reaction with this antiserum. 4. Cross-reactivity to other wheat proteins was less than 1% and no cross-reactivity to extracts of rye, barley or oats was observed. 5. This radioimmunoassay for alpha- and beta-gliadin has been used to measure their amount in different varieties of wheat flour, several foods prepared from flour, e.g. bread, biscuits and products prepared as 'gluten free'. The possibility of assaying for alpha-gliadin in prepared foods is of special value since alpha-, beta-, gamma- and omega-gliadin have been shown to exacerbate coeliac disease.

  5. {alpha}-{alpha} interaction reexamined in the context of the Sao Paulo potential: possible applications in astrophysics?

    Energy Technology Data Exchange (ETDEWEB)

    Gasques, L.R.; Chamon, L.C.; Botero, D.F.M. [Universidade de Sao Paulo (DFN/USP), SP (Brazil). Dept. de Fisica Nuclear; Alves, L.F.M. [Instituto Federal de Educacao, Ciencia e Tecnologia (Brazil); Carlson, B.V. [Instituto Tecnologico de Aeronautica (CTA/ITA), Sao Jose dos Campos, SP (Brazil). Dept. de Fisica Nuclear; Rossi Junior, E.S. [Centro Universitario FIEO(UNIFIEO), SP (Brazil)


    Full text: We have analyzed a large set of {alpha}-{alpha} elastic scattering data for bombarding energies ranging from 0.6 to 29.5 MeV. The complete lack of open reaction channels at these somehow low energies results in a vanishing imaginary part for the optical interaction. This characteristic makes the {alpha}-{alpha} reaction particularly interesting as the corresponding elastic scattering cross sections and phase shifts become very sensitive to the real part of the interaction. The data were analyzed within the context of the velocity-dependent Sao Paulo potential, which is a successful theoretical model for the description of heavy-ion reactions from sub-barrier to intermediate energies. We have shown that, even in this low energy region, the velocity dependence of the Sao Paulo potential model is a necessary ingredient for describing the data. Despite the reasonable description obtained with the Sao Paulo potential, the analyses indicate the necessity of an additional weak dependence of the interaction on the angular momentum. These important characteristics open the possibility for studying reactions with astrophysical interested. In particular, predictions of the astrophysical S-factor for the {sup 12}C({alpha},{gamma}) reaction will be presented. The understanding of the reaction rate for the {alpha}-capture process by a {sup 12}C nucleus is a crucial ingredient for predicting the stellar helium burning and the subsequent fate of stars as this reaction determines the ratio of carbon to oxygen towards the end of the Red Giants phase. It is well known that low mass stars evolve to White Dwarfs and this ratio determines the final abundance composition in White Dwarf matter and sets the trigger conditions for type Ia supernova explosions. The carbon-oxygen ratio also dictates the subsequent sequence of burning processes during the final stages of stellar evolution for massive stars. Thus, it has a key role in the determination of the abundance composition in

  6. Lyman-alpha observations of astrospheres

    CERN Document Server

    Linsky, Jeffrey L


    Charge-exchange reactions between outflowing stellar wind protons and interstellar neutral hydrogen atoms entering a stellar astrosphere produce a region of piled-up-decelerated neutral hydrogen called the hydrogen wall. Absorption by this gas, which is observed in stellar Lyman-alpha emission lines, provides the only viable technique at this time for measuring the mass-loss rates of F-M dwarf stars. We describe this technique, present an alternative way for understanding the relation of mass-loss rate with X-ray emission, and identify several critical issues.

  7. Selective effects of alpha interferon on human T-lymphocyte subsets during mixed lymphocyte cultures

    DEFF Research Database (Denmark)

    Hokland, M; Hokland, P; Heron, I


    Mixed lymphocyte reaction (MLR) cultures of human lymphocyte subsets with or without the addition of physiological doses of human alpha interferon (IFN-alpha) were compared with respect to surface marker phenotypes and proliferative capacities of the responder cells. A selective depression on the T...

  8. Highly efficient ytterbium triflate catalyzed Michael additions of alpha-nitroesters in water

    NARCIS (Netherlands)

    Keller, E; Feringa, B.L.


    Michael additions of alpha-nitroesters with enones and alpha,beta-unsaturated aldehydes result in quantitative conversions to the corresponding 1,4-adducts by performing the reactions in water in the presence of ytterbium triflate as water-tolerant Lewis acid.

  9. Identification alpha and gamma quantum at the pulse shape of the scintillates splash

    Directory of Open Access Journals (Sweden)

    V. I. Kornaga


    Full Text Available The methods of different scintillates splash alpha and gamma quantum at the pulse shape have been considered in experiment researches of the core's structure and mechanisms of the nuclear reaction.

  10. Alpha-mannosidosis

    Directory of Open Access Journals (Sweden)

    Nilssen Øivind


    Full Text Available Abstract Alpha-mannosidosis is an inherited lysosomal storage disorder characterized by immune deficiency, facial and skeletal abnormalities, hearing impairment, and intellectual disability. It occurs in approximately 1 of 500,000 live births. The children are often born apparently normal, and their condition worsens progressively. Some children are born with ankle equinus or develop hydrocephalus in the first year of life. Main features are immune deficiency (manifested by recurrent infections, especially in the first decade of life, skeletal abnormalities (mild-to-moderate dysostosis multiplex, scoliosis and deformation of the sternum, hearing impairment (moderate-to-severe sensorineural hearing loss, gradual impairment of mental functions and speech, and often, periods of psychosis. Associated motor function disturbances include muscular weakness, joint abnormalities and ataxia. The facial trait include large head with prominent forehead, rounded eyebrows, flattened nasal bridge, macroglossia, widely spaced teeth, and prognathism. Slight strabismus is common. The clinical variability is significant, representing a continuum in severity. The disorder is caused by lysosomal alpha-mannosidase deficiency. Alpha-mannosidosis is inherited in an autosomal recessive fashion and is caused by mutations in the MAN2B1 gene located on chromosome 19 (19 p13.2-q12. Diagnosis is made by measuring acid alpha-mannosidase activity in leukocytes or other nucleated cells and can be confirmed by genetic testing. Elevated urinary secretion of mannose-rich oligosaccharides is suggestive, but not diagnostic. Differential diagnoses are mainly the other lysosomal storage diseases like the mucopolysaccharidoses. Genetic counseling should be given to explain the nature of the disease and to detect carriers. Antenatal diagnosis is possible, based on both biochemical and genetic methods. The management should be pro-active, preventing complications and treating

  11. Alpha phoenix公司

    Institute of Scientific and Technical Information of China (English)


    德国Alpha phoenix公司成立于2009年.专注于制药领域清洗机器的研发和生产,产品符合cGMP的要求。公司的人员是制药领域清洗机器研发和生产的专家,他们具有20多年的全自动清洗机器的设计和生产经验。

  12. Engineering of hydrolysis reaction specificity in the transglycosylase cyclodextrin glycosyltransferase

    NARCIS (Netherlands)

    Leemhuis, H; Dijkhuizen, L


    Cyclodextrin glycosyltransferase (CGTase) is a member of the alpha-amylase family, a large group of enzymes that act on alpha-glycosidic bonds in starch and related compounds. Over twenty different reaction and product specificities have been found in this family. Although three-dimensional structur

  13. Efficient alpha-Methylenation of Carbonyl Compounds in Ionic Liquids at Room Temperature


    Vale, JA; Zanchetta, DF; Moran, PJS; RODRIGUES, JAR


    The application of several 1-butyl-3-methylimidazolium (BMIM) salt ionic liquids as solvent in the alpha-methylenation of carbonyl compounds at room temperature is reported. The ionic liquid [BMIM][NTf(2)] gave a clean reaction in a short time and good yields of several alpha-methylene carbonyl compounds. This ionic liquid was reused without affecting the reaction rates or yields over seven runs.

  14. Glutathione transferase mimics : Micellar catalysis of an enzymic reaction

    NARCIS (Netherlands)

    Lindkvist, Björn; Weinander, Rolf; Engman, Lars; Koetse, Marc; Engberts, Jan B.F.N.; Morgenstern, Ralf


    Substances that mimic the enzyme action of glutathione transferases (which serve in detoxification) are described. These micellar catalysts enhance the reaction rate between thiols and activated halogenated nitroarenes as well as alpha,beta-unsaturated carbonyls. The nucleophilic aromatic substituti

  15. Are alpha-gliadins glycosylated? (United States)

    Turner, J B; Garner, G V; Gordon, D B; Brookes, S J; Smith, C A


    Alpha-gliadins isolated by carboxymethylcellulose chromatography contain noncovalently bound glucose probably due to contaminating proteoglycans and to material shed from the column. Traces of carbohydrate remain strongly bound to alpha-gliadins even after harsh denaturation, but our results indicate alpha-gliadins are not glycoproteins. Suggestions that gliadins are glycoproteins are probably due to contamination with this glucose and the presence of these proteoglycans.

  16. Robust estimation of Cronbach's alpha



    Cronbach’s alpha is a popular method to measure reliability, e.g. in quantifying the reliability of a score to summarize the information of several items in questionnaires. The alpha coefficient is known to be non-robust. We study the behavior of this coefficient in different settings to identify situations, which can easily occur in practice, but under which the Cronbach’s alpha coefficient is extremely sensitive to violations of the classical model assumptions. Furthermore, we construct a r...

  17. An alpha particle instrument with alpha, proton, and X-ray modes for planetary chemical analyses (United States)

    Economou, T. E.; Turkevich, A. L.


    The interaction of alpha particles with matter is employed in a compact instrument that could provide rather complete in-situ chemical analyses of surfaces and thin atmospheres of extraterrestrial bodies. The instrument is a miniaturized and improved version of the Surveyor lunar instrument. The backscattering of alpha particles and (alpha, p) reactions provide analytical data on the light elements (carbon-iron). An X-ray mode that detects the photons produced by the alpha sources provides sensitivity and resolution for the chemical elements heavier than about silicon. The X-rays are detected by semiconductor detectors having a resolution between 150 and 250 eV at 5.9 keV. Such an instrument can identify and determine with good accuracy 99 percent of the atoms (except hydrogen) in rocks. For many trace elements, the detecting sensitivity is a few ppm. Auxiliary sources could be used to enhance the sensitivities for elements of special interest. The instrument could probably withstand the acceleration involved in semi-hard landings.

  18. Screened Thermonuclear Reaction Rates on Magnetar Surfaces

    Institute of Scientific and Technical Information of China (English)

    LIU Hong-Lin; LUO Zhi-Quan; LIU Jing-Jing; LAI Xiang-Jun


    Improving Salpeter's method, we discuss the effect of superstrong magnetic fields (such as those of magnetars) on thermonuclear reaction rates. These most interesting reactions, including the hydrogen burning by the CNO cycle and the helium burning by the triple alpha reaction, are investigated as examples on the magnetar surfaces. The obtained result shows that the superstrong magnetic fields can increase the thermonuclear reaction rates by many orders of magnitude. The enhancement may have significant influence for further study research of the magnetars, especially for the x-ray luminosity observation and the evolution of magnetars.

  19. PDFs, $\\alpha_s$, and quark masses from global fits

    CERN Document Server

    Alekhin, S; Moch, S; Placakyte, R


    The strong coupling constant $\\alpha_s$ and the heavy-quark masses, $m_c$, $m_b$, $m_t$ are extracted simultaneosly with the parton distribution functions (PDFs) in the updated ABM12 fit including recent data from CERN-SPS, HERA, Tevatron, and the LHC. The values of \\begin{eqnarray} \

  20. Molecular characterization of alpha 1- and alpha 2-adrenoceptors. (United States)

    Harrison, J K; Pearson, W R; Lynch, K R


    Three 'alpha 1-adrenoceptors' and three 'alpha 2-adrenoceptors' have now been cloned. How closely do these receptors match the native receptors that have been identified pharmacologically? What are the properties of these receptors, and how do they relate to other members of the cationic amine receptor family? Kevin Lynch and his colleagues discuss these questions in this review.

  1. Complete remission of multiple myeloma after autoimmune hemolytic anemia: possible association with interferon-alpha. (United States)

    Gesundheit, Benjamin; Zelig, Orly; Shapira, Michael Y; Ackerstein, Aliza; Avgil, Meytal; Or, Reuven


    A patient with multiple myeloma (MM) was being maintained on human recombinant interferon-alpha (INF-alpha) after VAD and autologous bone marrow transplantation (pretreated with melphalan). An episode of immune thrombocytopenia and (Coombs positive) autoimmune hemolytic anemia (AIHA) was noted while on maintenance INF-alpha, which remitted when it was withdrawn. Following this event, he achieved a state of stable disease that persists (more than 3 years) with no specific myeloma treatment. This sequence of events suggests a relationship between an immunological reaction induced by INF-alpha and the prolonged phase of stable disease.

  2. First direct measurement of resonance strengths in 17O({\\alpha}, {\\gamma})21Ne

    CERN Document Server

    Best, A; Couder, M; deBoer, R; Falahat, S; Kontos, A; LeBlanc, P J; Li, Q; O'Brien, S; Sonnabend, K; Talwar, R; Uberseder, E; Wiescher, M


    The reaction 17O({\\alpha},{\\gamma})21Ne has been measured by in-beam gamma spectroscopy for the first time in the energy range E{\\alpha} = 750 keV to 1650 keV using highly enriched anodized Ta2(17O)5 targets. Resonances were found at E({\\alpha}) = 1002 keV, 1386 keV and 1619 keV. Their strengths and primary gamma-ray branchings are given. The new results exclude the low reaction rate of Descouvemont and support the rate of Caughlan and Fowler. Implications for the neutron poisoning efficiency of 16O in the weak s process are discussed.

  3. Alpha-mannosidosis

    DEFF Research Database (Denmark)

    Borgwardt, Line Gutte; Danielsen, E R; Thomsen, Carsten;


    Alpha-mannosidosis (AM) (OMIM 248500) is a rare lysosomal storage disease. The understanding of the central nervous system (CNS) pathology is limited. This study is the first describing the CNS pathology and the correlation between the CNS pathology and intellectual disabilities in human AM. Thirty......-protein, glial fibrillary acidic protein and neurofilament light protein in 97 patients, 74% and 41% of CSF samples, respectively. A negative correlation between CSF-biomarkers and cognitive function and CSF-oligosaccharides and cognitive function was found. The combination of MRS/MRI changes, elevated...... concentrations of CSF-biomarkers and CSF-oligosaccharides suggests gliosis and reduced myelination, as part of the CNS pathology in AM. Our data demonstrate early neuropathological changes, which may be taken into consideration when planning initiation of treatment....

  4. Substitutional and Interstitial Diffusion in alpha2-Ti3Al(O) (United States)

    Copland, Evan; Young, David J.; Gleeson, Brian; Jacobson, Nathan


    The reaction between Al2O3 and alpha2-Ti3Al was studied with a series of Al2O3/alpha2-Ti3Al multiphase diffusion couples annealed at 900, 1000 and 1100 C. The diffusion-paths were found to strongly depend on alpha2- Ti3Al(O) composition. For alloys with low oxygen concentrations the reaction involved the reduction of Al2O3, the formation of a gamma-TiAl reaction-layer and diffusion of Al and O into the alpha2-Ti3Al substrate. Measured concentration profiles across the interaction-zone showed "up-hill" diffusion of O in alpha2-Ti3Al(O) indicating a significant thermodynamic interaction between O and Al, Ti or both. Diffusion coefficients for the interstitial O in alpha2-Ti3Al(O) were determined independently from the interdiffusion of Ti and Al on the substitutional lattice. Diffusion coefficients are reported for alpha2-Ti3Al(O) as well as gamma-TiAl. Interpretation of the results were aided with the subsequent measurement of the activities of Al, Ti and O in alpha 2-Ti3Al(O) by Knudsen effusion-cell mass spectrometry.

  5. Action pattern of human pancreatic and salivary alpha-amylase on 1,4-alpha-D-nitrophenylmaltooligosaccharides. 1,4-alpha-D-nitrophenylmaltooligosaccharides as substrates of alpha-amylse, I. (United States)

    Wallenfels, K; Laule, G; Meltzer, B


    High performance liquid chromatography (HPLC) was used to monitor the purity of the substrates and to establish the patterns of hydrolysis of ortho- and para-nitrophenylmaltooligosaccharides (2-7 glucose residues) catalysed by human pancreatic and salivary alpha-amylase. Separation of the reaction products from the remaining substrate was performed on a TSK-G-2000 PW or a RP18 column. By measuring the quantitative distribution of products, and assuming a 5-subsite model for the active site of alpha-amylase, differential activities for the hydrolysis of the different glycosidic bonds in the 2 series of substrates were deduced. A highly sensitive coupled continuous assay system is based on the formation of phenyloligosaccharides with 1-4 glucose residues by the action of the amylase under test, coupled to hydrolysis of these products by yeast alpha-glucosidase. The most suitable test substrates were shown to be para-nitrophenyl-alpha-D-maltotetraoside and -pentaoside. Direct production of nitrophenol from ortho-nitrophenyl-alpha-D-maltotrioside is recommended for the measurement of the alpha-amylase activity of pancreatic and salivary gland secretions and extracts.


    Recent DFT optimization studies on alpha-maltose improved our understanding of the preferred conformations of alpha-maltose and the present study extends these studies to alpha-maltotriose with three alpha-D-glucopyranose residues linked by two alpha-[1-4] bridges, denoted herein as DP-3's. Combina...

  7. The ALPHA antihydrogen trapping apparatus

    Energy Technology Data Exchange (ETDEWEB)

    Amole, C. [Department of Physics and Astronomy, York University, Toronto ON Canada, M3J 1P3 (Canada); Andresen, G.B. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Ashkezari, M.D. [Department of Physics, Simon Fraser University, Burnaby, BC Canada, V5A 1S6 (Canada); Baquero-Ruiz, M. [Department of Physics, University of California at Berkeley, Berkeley, CA 94720-7300 (United States); Bertsche, W. [Department of Physics, College of Science, Swansea University, Swansea SA2 8PP (United Kingdom); School of Physics and Astronomy, University of Manchester, Manchester M13 9PL (United Kingdom); The Cockcroft Institute, Warrington WA4 4AD (United Kingdom); Bowe, P.D. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Butler, E. [Physics Department, CERN, CH-1211 Geneva 23 (Switzerland); Capra, A. [Department of Physics and Astronomy, York University, Toronto ON Canada, M3J 1P3 (Canada); Carpenter, P.T. [Department of Physics, Auburn University, Auburn, AL 36849-5311 (United States); Cesar, C.L. [Instituto de Física, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-972 (Brazil); Chapman, S. [Department of Physics, University of California at Berkeley, Berkeley, CA 94720-7300 (United States); Charlton, M.; Deller, A.; Eriksson, S. [Department of Physics, College of Science, Swansea University, Swansea SA2 8PP (United Kingdom); Escallier, J. [Brookhaven National Laboratory, Upton, NY 11973 (United States); Fajans, J. [Department of Physics, University of California at Berkeley, Berkeley, CA 94720-7300 (United States); Friesen, T. [Department of Physics and Astronomy, University of Calgary, Calgary AB, Canada, T2N 1N4 (Canada); Fujiwara, M.C.; Gill, D.R. [TRIUMF, 4004 Wesbrook Mall, Vancouver BC, Canada V6T 2A3 (Canada); Gutierrez, A. [Department of Physics and Astronomy, University of British Columbia, Vancouver BC, Canada V6T 1Z4 (Canada); and others


    The ALPHA collaboration, based at CERN, has recently succeeded in confining cold antihydrogen atoms in a magnetic minimum neutral atom trap and has performed the first study of a resonant transition of the anti-atoms. The ALPHA apparatus will be described herein, with emphasis on the structural aspects, diagnostic methods and techniques that have enabled antihydrogen trapping and experimentation to be achieved.

  8. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.


    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  9. Proteinaceous alpha-araylase inhibitors

    DEFF Research Database (Denmark)

    Svensson, Birte; Fukuda, Kenji; Nielsen, P.K.;


    Proteins that inhibit alpha-amylases have been isolated from plants and microorganisms. These inhibitors can have natural roles in the control of endogenous a-amylase activity or in defence against pathogens and pests; certain inhibitors are reported to be antinutritional factors. The alpha-amylase...... inhibitors belong to seven different protein structural families, most of which also contain evolutionary related proteins without inhibitory activity. Two families include bifunctional inhibitors acting both on alpha-amylases and proteases. High-resolution structures are available of target alpha-amylases...... in complex with inhibitors from five families. These structures indicate major diversity but also some similarity in the structural basis of alpha-amylase inhibition. Mutational analysis of the mechanism of inhibition was performed in a few cases and various protein engineering and biotechnological...

  10. Exploring clustering in alpha-conjugate nuclei using the thick target inverse kinematic technique for multiple alpha emission (United States)

    Barbui, M.; Hagel, K.; Gauthier, J.; Wuenschel, S.; Goldberg, V. Z.; Zheng, H.; Giuliani, G.; Rapisarda, G.; Kim, E.-J.; Liu, X.; Natowitz, J. B.; Desouza, R. T.; Hudan, S.; Fang, D.


    Searching for alpha cluster states analogous to the 12C Hoyle state in heavier alpha-conjugate nuclei can provide tests of the existence of alpha condensates in nuclear matter. Such states are predicted for 16O, 20Ne, 24Mg, etc. at excitation energies slightly above the decay threshold. The Thick Target Inverse Kinematics (TTIK) technique can be successfully used to study the breakup of excited self-conjugate nuclei into many alpha particles. The reaction 20Ne + α at 11 and 13 AMeV was studied at Cyclotron Institute at Texas A&M University. Here the TTIK method was used to study both single α-particle emission and multiple α-particle decays. Due to the limited statistics, only events with alpha multiplicity up to three were analyzed. The analysis of the three α-particle emission data allowed the identification of the Hoyle state and other 12C excited states decaying into three alpha particles. The results will be shown and compared with other data available in the literature. Another experiment is planned in August 2015 to study the system 28Si + α at 15 AMeV. Preliminary results will be shown. Supported by the U.S. DOE and the Robert A. Welch Foundation, Grant No. A0330.

  11. Pre-Equilibrium Alpha-Particle Emission as a Probe to Explore Alpha Clustering in Nuclei (United States)

    Kravchuk, V. L.; Fotina, O. V.; Gramegna, F.; Bruno, M.; D'Agostino, M.; Sambi, S.; Barlini, S.; Casini, G.

    Experimental data of the double-differential spectra of light particles emitted at pre-equilibrium stage of nuclear processes were obtained at Laboratori Nazionali di Legnaro for the heavy-ion reactions 130 and 250 MeV 16O + 116Sn. Light charged particles were measured in coincidence with evaporation residues in order to avoid unwanted competing mechanisms. The experimental data were collected in a wide angular range from 29 to 82 degrees in the laboratory system. Theoretical model was developed in order to describe simultaneously evaporative and pre-equilibrium emission of the light particles in heavy-ion reactions. Griffin exciton model was used for the description of the pre-equilibrium stage of the compound nucleus formation, while the equilibrium evaporation processes were analyzed in the framework of the statistical theory of heavy-ion reactions. Experimental data were compared with the results of the model calculations and new approach was suggested to take into account alpha cluster formation in the projectile nucleus by measuring and analyzing pre-equilibrium alpha-particle spectra.

  12. Mechanism of radiation graft of methyl-. cap alpha. -fluoroacrylate and. cap alpha. ,. beta. ,. beta. -trifluorostyrene on perfluorinated copolymer. [Cobalt 60

    Energy Technology Data Exchange (ETDEWEB)

    Ivankin, A.N.; Tevlina, A.S.; Zagorets, P.A. (Moskovskij Khimiko-Tekhnologicheskij Inst. (USSR))


    The kinetics of radiation-induced graft copolymerization of methyl-..cap alpha..-fluoroacrylate and ..cap alpha.., ..beta.., ..beta..-trifluorostyrene to perfluorinated copolymer of hexafluoropropylene with tetrafluoroethylene has been studied. The orders of the grafting reaction towards the monomer and dose rate as well as the values of rate constants of radiation-induced grafting at various temperatures were determined, the effective activation energy of grafting (20.6 kJ/mol) was calculated. The kinetic scheme of elementary acts of radiation-induced graft copolymerization is discussed.

  13. Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum. (United States)

    Porcu, Patrizia; O'Buckley, Todd K; Alward, Sarah E; Marx, Christine E; Shampine, Lawrence J; Girdler, Susan S; Morrow, A Leslie


    The 3alpha,5alpha- and 3alpha,5beta-reduced derivatives of progesterone, deoxycorticosterone, dehydroepiandrosterone and testosterone enhance GABAergic neurotransmission and produce inhibitory neurobehavioral and anti-inflammatory effects. Despite substantial information on the progesterone derivative (3alpha,5alpha)-3-hydroxypregnan-20-one (3alpha,5alpha-THP, allopregnanolone), the physiological significance of the other endogenous GABAergic neuroactive steroids has remained elusive. Here, we describe the validation of a method using gas chromatography-mass spectrometry to simultaneously identify serum levels of the eight 3alpha,5alpha- and 3alpha,5beta-reduced derivatives of progesterone, deoxycorticosterone, dehydroepiandrosterone and testosterone. The method shows specificity, sensitivity and enhanced throughput compared to other methods already available for neuroactive steroid quantification. Administration of pregnenolone to rats and progesterone to women produced selective effects on the 3alpha,5alpha- and 3alpha,5beta-reduced neuroactive steroids, indicating differential regulation of their biosynthetic pathways. Pregnenolone administration increased serum levels of 3alpha,5alpha-THP (+1488%, psteroid was detected only in 3/16 control subjects. Levels of 3alpha,5alpha-A, 3alpha,5beta-A and pregnenolone were not altered. This method can be used to investigate the physiological and pathological role of neuroactive steroids and to develop biomarkers and new therapeutics for neurological and psychiatric disorders.

  14. Radiative Corrections to the Muonium Hyperfine Structure; 2, The $\\alpha (Z\\alpha)^2$ Correction

    CERN Document Server

    Nio, M


    This is the second of a series of papers on the radiative corrections of order $\\alpha^2 (Z\\alpha)$, $\\alpha (Z\\alpha )^2$, and various logarithmic terms of order $\\alpha^4$, to the hyperfine structure of the muonium ground state. This paper deals with the $\\alpha (Z\\alpha)^2$ correction. Based on the NRQED bound state theory, we isolated the term of order $\\alpha(Z\\alpha)^2$ exactly. Our result $+16.904~2~(11) \\alpha(Z\\alpha)^2 E_F / \\pi$ for the non-logarithmic part is consistent with the $\\alpha (Z\\alpha)^2$ part of Sapirstein's calculation and the recent result of Pachucki, and reduces the numerical uncertainty in the $\\alpha (Z\\alpha)^2$ term by two orders of magnitude.

  15. ALPHA freezes antiprotons

    CERN Multimedia

    CERN Bulletin


    Laboratories like CERN can routinely produce many different types of antiparticles. In 1995, the PS210 experiment formed the first antihydrogen atoms and a few years later, in 2002, ATRAP and ATHENA were already able to produce several thousand of them. However, no experiment in the world has succeeded in ‘trapping’ these anti-atoms in order to study them. This is the goal of the ALPHA experiment, which has recently managed to cool down the antiprotons to just a few Kelvin. This represents a major step towards trapping the anti-atom, thus opening a new avenue into the investigation of antimatter properties.   Members of the ALPHA collaboration working on the apparatus in the Antiproton Decelerator experimental hall at CERN. Just like the atom, the anti-atom is neutral. Unlike the atom, the anti-atom is made up of antiprotons (as opposed to protons in the atom) and positrons (as opposed to electrons). In order to thoroughly study the properties of the anti-atoms, scien...

  16. Venus - Alpha Regio (United States)


    The eastern edge of Alpha Regio is shown in this image centered at 30 degrees south latitude and 11.8 degrees east longitude (longitude on Venus is measured from 0 degrees to 360 degrees east). Seven circular, dome-like hills, averaging 25 kilometers (15 miles) in diameter with maximum heights of 750 meters (2,475 feet) dominate the scene. These features are interpreted as very thick lava flows that came from an opening on the relatively level ground, which allowed the lava to flow in an even pattern outward from the opening. The complex fractures on top of the domes suggest that if the domes were created by lava flows, a cooled outer layer formed and then further lava flowing in the interior stretched the surface. The domes may be similar to volcanic domes on Earth. Another interpretation is that the domes are the result of molten rock or magma in the interior that pushed the surface layer upward. The near-surface magma then withdrew to deeper levels, causing the collapse and fracturing of the dome surface. The bright margins possibly indicate the presence of rock debris on the slopes of the domes. Some of the fractures on the plains cut through the domes, while others appear to be covered by the domes. This indicates that active processes pre date and post date the dome-like hills. The prominent black area in the northeast corner of the image is a data gap. North is at the top of the image.

  17. Partitioning $\\alpha$-large sets for $\\alpha<\\varepsilon_{\\omega}$

    CERN Document Server

    De Smet, Michiel


    We generalise the results by Bigorajska and Kotlarski about partitioning $\\alpha$-large sets, by extending the domain up to ordinals below $\\varepsilon_{\\omega}$. These results will be very useful to give a miniaturisation of the infinite Ramsey Theorem.

  18. Two alpha, three alpha and multiple heavy-ion radioactivities

    Energy Technology Data Exchange (ETDEWEB)

    Poenaru, D.N.; Ivascu, M. (Institute for Physics and Nuclear Engineering, Bucharest (Romania))


    New decay modes by spontaneous emission of two and three ..cap alpha.. particles and two identical or different heavy ions, are predicted. The analytical variant of the superasymmetric fission model is used to estimate the half lives.

  19. Characterization of 3alpha-acetyl-11-keto-alpha-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo. (United States)

    Büchele, Berthold; Zugmaier, Waltraud; Estrada, Aidee; Genze, Felicitas; Syrovets, Tatiana; Paetz, Christian; Schneider, Bernd; Simmet, Thomas


    3Alpha-acetyl-11-keto-alpha-boswellic acid (3alpha-acetoxy-11-oxo-olean-12-en-24-oic acid, 1) was synthesized by a radical-type reaction using bromine and 3alpha-acetyl-alpha-boswellic acid isolated from the oleo-gum-resin of Boswellia carterii. 1D and 2D NMR (COSY, HMBC, ROESY) at 500 MHz were used for shift assignments and structure verification. The compound investigated is present in a herbal preparation extracted from Boswellia serrata oleo-gum-resin, it inhibits the growth of chemotherapy-resistant human PC-3 prostate cancer cells in vitro and induces apoptosis as shown by activation of caspase 3 and the induction of DNA fragmentation. In addition, compound 1 is active IN VIVO as shown by inhibition of proliferation and induction of apoptosis in PC-3 prostate cancer cells xenotransplanted onto the chick chorioallantoic membrane.

  20. Alpha heating in toroidal devices

    Energy Technology Data Exchange (ETDEWEB)

    Miley, G.H.


    Ignition (or near-ignition) by alpha heating is a key objective for the achievement of economic fusion reactors. While good confinement of high-energy alphas appears possible in larger reactors, near-term tokamak-type ignition experiments as well as some concepts for small reactors (e.g., the Field-Reversed Mirror or FRM) potentially face marginal situations. Consequently, there is a strong motivation to develop methods to evaluate alpha losses and heating profiles in some detail. Such studies for a TFTR-size tokamak and for a small FRM are described here.

  1. Alpha Conjugate Neck Structures in the Collisions of 35 MeV/nucleon 40Ca with 40Ca

    CERN Document Server

    Schmidt, K; Kim, E J; Hagel, K; Barbui, M; Gauthier, J; Wuenschel, S; Giuliani, G; Rodrigues, M R D; Zheng, H; Huang, M; Blando, N; Bonasera, A; Wada, R; Botosso, C; Liu, G; Viesti, G; Moretto, S; Prete, G; Pesente, S; Fabris, D; Masri, Y El; Keutgen, T; Kolwaski, S; Kumar, A; Zhang, G; Natowitz, J B


    The de-excitation of alpha-conjugate nuclei produced in reactions of 35 MeV/nucleon 40Ca with 40Ca has been investigated. Particular emphasis is placed on examining the dynamics of collisions leading to projectile-like fragment exit channels. A general exploration of the reaction systematics reveals the binary dissipative character of the collisions and a hierarchy effect similar to that seen for heavier systems. Investigation of the subset of events characterized by a total alpha-conjugate mass (alpha particles plus alpha-conjugate fragments) equal to 40 and atomic number equal to 20 reveals a dominance of alpha-conjugate exit channels. The hierarchy effect for these channels leads to the production of alpha-clustered neck structures with potentially exotic geometries and properties.

  2. Synthesis of Long Chain Unsaturated-alpha,omega-Dicarboxylic Acids from Renewable Materials via Olefin Metathesis (United States)

    The self-metathesis reaction of soy, rapeseed, tall, and linseed oil fatty acids was investigated for the synthesis of symmetrical long-chain unsaturated-alpha,omega-dicarboxylic acids. The metathesis reactions were carried out in the presence of a Grubbs catalyst under solvent-free conditions at a...

  3. Protonation and lactonization of {alpha}-iso-saccharinic acid

    Energy Technology Data Exchange (ETDEWEB)

    Rao, L.; Tian, G. [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Zhang, Z. [Washington State University, Pullman, WA 99165 (United States); Rai, D. [Pacific Northwest National Laboratory, Richland, WA 99352 (United States)


    Full text of publication follows: {alpha}-iso-saccharinic acid, a degradation product of cellulose materials, has been a subject of study due to its ability to complex actinides and affect their migration behavior in the environment. Like other poly-hydroxy-carboxylic acids such as gluconic acid, {alpha}-iso-saccharinic acid undergoes dehydration to form {alpha}-iso-saccharinate-1,4-lactone in acidic solutions. The lactonization of iso-saccharinic acid is slower than the protonation/deprotonation reactions because it involves breaking and formation of C-O as well as O-H bonds. It is important to take into consideration the slow lactonization reaction when determining the protonation constant of iso-saccharinic acid. In this work, the protonation of a-iso-saccharinate and the lactonization of {alpha}-iso-saccharinic acid have been evaluated by potentiometry. A concept of 'composite' protonation constant, similar to the well-known composite protonation constant of carbonic acid [1], is developed for {alpha}- iso-saccharinic acid. Results on the protonation and lactonization of {alpha}-iso-saccharinic acid are discussed in comparison with gluconic acid. This research was supported by the Office of Science, Office of Basic Energy Sciences and Office of Biological and Environmental Research, U.S. Department of Energy, under Contract No. DE-AC03-76SF0098 at Lawrence Berkeley National Laboratory. [1] Stumm, W., Morgan, J.J.: 'Aquatic Chemistry: an Introduction Emphasizing Chemical Equilibria in Natural Waters', John Wiley and Sons, New York (1981), pp. 173-174. (authors)

  4. Direct studies of low-energy resonances in {sup 31}P(p,{alpha}){sup 28}Si and {sup 35}Cl(p,{alpha}){sup 32}S

    Energy Technology Data Exchange (ETDEWEB)

    Moazen, B.H.; Jones, K.L.; Pittman, S.T. [University of Tennessee, Department of Physics and Astronomy, Knoxville, TN (United States); Matei, C. [Oak Ridge Associated Universities, Oak Ridge, TN (United States); Bardayan, D.W.; Smith, M.S. [Oak Ridge National Laboratory, Physics Division, Oak Ridge, TN (United States); Blackmon, J.C. [Louisiana State University, Department of Physics, Baton Rouge, LA (United States); Chae, K.Y.; Nesaraja, C.D. [University of Tennessee, Department of Physics and Astronomy, Knoxville, TN (United States); Oak Ridge National Laboratory, Physics Division, Oak Ridge, TN (United States); Chipps, K.A.; Matos, M. [Colorado School of Mines, Department of Physics, Golden, CO (United States); Hatarik, R.; O' Malley, P.D.; Pain, S.D.; Peters, W.A. [Rutgers University, Department of Physics and Astronomy, Piscataway, NJ (United States); Kozub, R.L.; Shriner, J.F. [Tennessee Technological University, Department of Physics, Cookeville, TN (United States); Pelham, T. [University of Surrey, Department of Physics, Guilford (United Kingdom)


    Low-energy resonances in {sup 31}P(p,{alpha}){sup 28}Si and {sup 35}Cl(p,{alpha}){sup 32}S were studied directly in order to gain a better understanding of reaction cycling in the Si-Ar region in novae. New resonance strengths at E{sub c.m.} = 600 and 622 keV in {sup 31}P(p,{alpha}){sup 28}Si were measured ({omega}{gamma}{sub p,{alpha}} = (2.2{+-}0.7) x 10{sup -2} eV and {omega}{gamma}{sub p,{alpha}} = (0.99{+-}0.08) eV, respectively) as well as the E{sub c.m.} = 610 keV resonance in {sup 35}Cl(p,{alpha}){sup 32}S [{omega}{gamma}{sub p,{alpha}} = (1.2{+-}0.2) x 10{sup -2} eV], the lowest energy that any resonance in this reaction has been observed, directly or indirectly. The strengths of these resonances were found to be lower than previously determined, resulting in even weaker cycling in the Si-Ar region. (orig.) (orig.)

  5. Pre-equilibrium {\\alpha}-particle emission as a probe to study {\\alpha}-clustering in nuclei

    CERN Document Server

    Fotina, O V; Eremenko, D O; Platonov, S Yu; Yuminov, O A; Kravchuk, V L; Gramegna, F; Marchi, T; Cinausero, M; D'Agostino, M; Bruno, M; Baiocco, G; Morelli, L; Degerlier, M; Casini, G; Barlini, S; Valdrè, S; Piantelli, S; Pasquali, G; Bracco, A; Camera, F; Wieland, O; Benzoni, G; Blasi, N; Giaz, A; Corsi, A


    A theoretical approach was developed to describe secondary particle emission in heavy ion collisions, with special regards to pre-equilibrium {\\alpha}-particle production. Griffin's model of non-equilibrium processes is used to account for the first stage of the compound system formation, while a Monte Carlo statistical approach was used to describe the further decay from a hot source at thermal equilibrium. The probabilities of neutron, proton and {\\alpha}-particle emission have been evaluated for both the equilibrium and pre-equilibrium stages of the process. Fission and {\\gamma}-ray emission competition were also considered after equilibration. Effects due the possible cluster structure of the projectile which has been excited during the collisions have been experimentally evidenced studying the double differential cross sections of p and {\\alpha}-particles emitted in the E=250MeV 16O +116Sn reaction. Calculations within the present model with different clusterization probabilities have been compared to th...

  6. The Lyman alpha reference sample

    DEFF Research Database (Denmark)

    Hayes, M.; Östlin, G.; Schaerer, D.


    We report on new imaging observations of the Lyman alpha emission line (Lyα), performed with the Hubble Space Telescope, that comprise the backbone of the Lyman alpha Reference Sample. We present images of 14 starburst galaxies at redshifts 0.028 alpha emission line (Lyα), performed with the Hubble Space Telescope, that comprise the backbone of the Lyman alpha Reference Sample. We present images of 14 starburst galaxies at redshifts 0.028 ... with quantities that scale with dust content, in the sense that a low dust abundance is a necessary requirement (although not the only one) in order to spread Lyα photons throughout the interstellar medium and drive a large extended Lyα halo. © 2013. The American Astronomical Society. All rights reserved....

  7. Measurement of differential (n,x{alpha}) cross section using 4{pi} gridded ionization chamber

    Energy Technology Data Exchange (ETDEWEB)

    Sanami, Toshiya; Baba, Mamoru; Matsuyama, Shigeo; Kiyosumi, Takehide; Nauchi, Yasushi; Saito, Keiichiro; Hirakawa, Naohiro [Tohoku Univ., Sendai (Japan). Faculty of Engineering; Kawano, Toshihiko


    We carried out the measurements of high resolution {alpha} emission spectra of {sup 58}Ni and {sup nat}Ni between 4.5 and 6.5 MeV, and {sup 12}C(n,x{alpha}) cross section using a 4{pi} gridded ionization chamber. In Ni measurement, overall energy resolution was improved to around 200 keV by optimizing a sample thickness and a neutron source width. Measured alpha spectra showed separate peaks corresponding to the ground and low-lying excited states of the residual nucleus ({sup 55}Fe). These results were compared with another direct measurement and statistical model calculations. In {sup 12}C measurement, GIC was applied for (n,x{alpha}) reactions of light nuclei. This application is difficult to (n,x{alpha}) cross sections of light nuclei, because of the influences of large recoil energy and multi-body break-up. We developed new methods which eliminate the effects of recoil nuclei and multi-body break-up and applied them to {sup 12}C(n,x{alpha}) reaction at En=14.1 MeV. In our experiment, the {sup 12}C(n,{alpha}{sub 0}){sup 9}Be angular differential cross section and {sup 12}C(n,n`3{alpha}) cross section were obtained. (author)

  8. Synthesis of graphene oxide-intercalated alpha-hydroxides by metathesis and their decomposition to graphene/metal oxide composites



    Graphene oxide-intercalated alpha-metal hydroxides were prepared using layers from the delaminated colloidal dispersions of cetyltrimethylammonium-intercalated graphene oxide and dodecylsulfate-intercalated alpha-hydroxide of nickel/cobalt as precursors. The reaction of the two dispersions leads to de-intercalation of the interlayer ions from both the layered solids and the intercalation of the negatively charged graphene oxide sheets between the positively charged layers of the alpha-hydroxi...

  9. Determining Equilibrium Constants for Dimerization Reactions from Molecular Dynamics Simulations

    NARCIS (Netherlands)

    De Jong, Djurre H.; Schafer, Lars V.; De Vries, Alex H.; Marrink, Siewert J.; Berendsen, Herman J. C.; Grubmueller, Helmut


    With today's available computer power, free energy calculations from equilibrium molecular dynamics simulations "via counting" become feasible for an increasing number of reactions. An example is the dimerization reaction of transmembrane alpha-helices. If an extended simulation of the two helices c

  10. Almost Redundant Components in the 3 alpha Faddeev Equation for the Buck, Friedlich and Wheatly alpha alpha Potential

    CERN Document Server

    Fujiwara, Y; Kohno, M


    The 3 alpha orthogonality condition model using the Pauli-forbidden bound states of the Buck, Friedlich and Wheatly alpha alpha potential can yield a compact 3 alpha ground state with a large binding energy, in which a small admixture of the redundant components can never be eliminated.

  11. Determination of {alpha}-widths in {sup 19}F relevant to fluorine nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, F. de [CSNSM, 91 - Orsay (France); Coc, A. [CSNSM, 91 - Orsay (France); Aguer, P. [CSNSM, 91 - Orsay (France); Angulo, C. [CSNSM, 91 - Orsay (France); Bogaert, G. [CSNSM, 91 - Orsay (France); Kiener, J. [CSNSM, 91 - Orsay (France); Lefebvre, A. [CSNSM, 91 - Orsay (France); Tatischeff, V. [CSNSM, 91 - Orsay (France); Thibaud, J.P. [CSNSM, 91 - Orsay (France); Fortier, S. [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire; Maison, J.M. [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire; Rosier, L. [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire; Rotbard, G. [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire; Vernotte, J. [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire; Arnould, M. [Universite Libre de Bruxelles (Belgium). Inst. d`Astronomie et d`Astrophysique; Jorissen, A. [Universite Libre de Bruxelles (Belgium). Inst. d`Astronomie et d`Astrophysique; Mowlavi, N. [Universite Libre de Bruxelles (Belgium). Inst. d`Astronomie et d`Astrophysique


    Nucleosynthesis of fluorine in the context of helium burning occurs through the {sup 15}N({alpha},{gamma}){sup 19}F reaction. At temperatures where fluorine formation takes place in most astrophysical models, the narrow resonance associated with the 4.378 MeV level of {sup 19}F is expected to dominate the reaction rate, but its strength is not known. We used a {sup 15}N confined gas target to study this level by means of the transfer reaction {sup 15}N({sup 7}Li,t){sup 19}F at 28 MeV. Reaction products were analysed with a split pole magnetic spectrometer and the angular distributions for the first 16 levels of {sup 19}F were extracted. These distributions are fairly well reproduced by FR-DWBA calculations in the framework of an {alpha}-cluster transfer model with a compound nucleus contribution obtained by Hauser-Feshbach calculations. {alpha}-spectroscopic factors were deduced and, for unbound levels, the {alpha}-widths were determined and compared with the existing direct measurements. The {alpha}-width of the level of astrophysical interest (E{sub x} 4.378 MeV) was found to be {Gamma}{sub {alpha}}=1.5 x 10{sup -9} eV, a value 60 times smaller than the commonly used one. The astrophysical consequences for {sup 19}F production in AGB stars are discussed. (orig.).

  12. Portable Neutron Generator with 9-Section Silicon $\\alpha $-Detector

    CERN Document Server

    Bystritsky, V M; Kadyshevskij, V G; Khasaev, T O; Kobzev, A P; Presnyakov, Yu K; Rogov,Yu N; Ryzhkov, V I; Sapozhnikov, M G; Sissakian, A N; Slepnev, V M; Zamyatin, N I


    The characteristics of the portable neutron generator with a built-in $\\alpha $-detector are presented. Based on the "tagged" neutron method (TNM) the generator ~is being used for identification of ~the hidden chemical compounds. One of the special features of such generators compared to generators traditionally used and produced in industry is that the generator is a source of monoenergetic "tagged" 14.1 MeV neutrons produced in the binary nuclear reaction $d+t \\to \\alpha $ (3.5 MeV) $+n$ (14.1~MeV). Unambiguous information about the time and direction of the neutron emitted from the target can be obtained by recording an $\\alpha $ particle by the multi-pixel $\\alpha $-detector placed inside the neutron tube. The study of the "tagged" neutron method (TNM) shows that the use of the ($\\alpha $--$\\gamma $) coincidence reduces the gamma background induced by scattered neutrons by a factor of more than 200, which allows the detection and identification of small quantities of explosives, drugs, and toxic agents. T...

  13. Cyclotron production of Ac-225 for targeted alpha therapy. (United States)

    Apostolidis, C; Molinet, R; McGinley, J; Abbas, K; Möllenbeck, J; Morgenstern, A


    The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8 MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8 MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer.

  14. Photolysis of alpha-xylyl chlorides: an efficient deep-UV photoinitiating system for radical and cationic polymerization. (United States)

    Ponce, Patricia; Catalani, Luiz Henrique


    Photoacid generators (PAG) are chemical systems where light absorption renders strong acid formation, typically with quantum yields greater than one. Many compounds bearing halogen atoms are reported to produce hydrogen halides upon photolysis. Here, alpha-chloroxylene derivatives (ortho, meta and para) were subject of a photolysis study in order to: (i) determine the operative mechanism, (ii) identify the products formed and (iii) quantify the amount of HCl formed. Product structure and quantum yields of HCl formation where determined for the photolysis of alpha-chloro-o-xylene (1), alpha-chloro-m-xylene (2), alpha-chloro-p-xylene (3), alpha, alpha'-dichloro-o-xylene (4), alpha, alpha'-dichloro-m-xylene (5) and alpha, alpha'-dichloro-p-xylene (6) in apolar (benzene, cumene, ethylbenzene, toluene and isooctane) and polar (methanol, n-propanol, isopropyl alcohol) solvents. Some of these compounds were analysed by laser flash photolysis in argon-purged isooctane as solvent to examine the possible reaction intermediates involved. The observed products are derived from typical radical reactions like recombination, dimerization and hydrogen abstraction from the starting compound or from solvents. The formation of HCl is expected as the result of C-Cl homolysis followed by hydrogen abstraction by chlorine atom. The results showed yields ranging from 1.2 to 18, depending on the conditions used. These numbers indicate the potential use of these compounds as PAG systems for the deep UV region.

  15. Neutron and Alpha Structure in Neutron Deficient Nuclei in Astrophysics

    Institute of Scientific and Technical Information of China (English)

    S. Kubono; T. Hashimoto; Y. Wakabayashi; N. Iwasa; S. Kato; T. Komatsubara; D. N. Binh; L. H. Khiem; N. N. Duy; T. Kawabata; C. Spitaleri; 何建军; G. G. Rapisarda; M. La Cognata; L. Lamia; R. G. Pizzone; S. Romano; A. Coc; N. de Sereville; F. Hammache; G. Kiss; S. Bishop; H. Yamaguchi; D. M. Kahl; S. Hayakawa; T. Teranishi; S. Cheribini; M. Gulino; Y. K. Kwon


    The paper includes discussions on the important role of neutron and alpha configurations in proton-rich nuclei in nuclear astrophysics in terms of nucleosynthesis under extremely high-temperature hydrogenburning conditions. The νp-process, which is supposed to take place at the very early epoch of type II supernovae, has considerable neutrons and alphas together with protons. The alpha-induced reactions on proton-rich unstable nuclei in the light mass regions is expected to play a crucial role, but very few of them were investigated well yet because of the experimental difficulties. Specifically, I report our recent experimental effort for the breakout process from the pp-chain region, 7Be(α,γ)11C(α,p)14N under the νp-process. The neutron-induced reactions on proton-rich nuclei, which is even more a challenging subject, were investigated previously for very few nuclei. One possible experimental method is the Trojan Horse Method (THM). We successfully have applied THM to the 18F(n,α)14N reaction study with an unstable beam of 18F.

  16. A complete kinematics approach to study multi-particle final state reactions

    Energy Technology Data Exchange (ETDEWEB)

    Alcorta, M. [Instituto de Estructura de la Materia, CSIC, Serrano 113 bis, Madrid E-28006 (Spain)], E-mail:; Kirsebom, O. [Department of Physics and Astronomy, University of Aarhus, DK-8000 Aarhus C (Denmark); Borge, M.J.G. [Instituto de Estructura de la Materia, CSIC, Serrano 113 bis, Madrid E-28006 (Spain); Fynbo, H.O.U.; Riisager, K. [Department of Physics and Astronomy, University of Aarhus, DK-8000 Aarhus C (Denmark); Tengblad, O. [Instituto de Estructura de la Materia, CSIC, Serrano 113 bis, Madrid E-28006 (Spain)


    Detection in complete kinematics using highly segmented detectors can provide detailed information on the structure of excited nuclear states and their decay mechanisms. The detection of final states consisting of several particles gives rise to many challenges. We present here new techniques that allow for the extraction of physics from the many open channels. In particular this complete kinematic analysis technique has been applied to data from low-energy, high Q-value, light-ion reactions {sup 10}B({sup 3}He,p{alpha}{alpha}{alpha}), {sup 11}B({sup 3}He,d{alpha}{alpha}{alpha}), and {sup 7}Li({sup 3}He,p{alpha}{alpha})n, all of them performed at the CMAM tandem accelerator in Madrid.

  17. Real-time operating mode with DSSSD detector to search for short correlation ER-alpha chains

    CERN Document Server

    Tsyganov, Yury


    Real-time PC based algorithm is developed for DSSSD detector. Complete fusion nuclear reaction natYb+48Ca->217Th is used to test this algorithm at 48Ca beam. Example of successful application of a former algorithm for resistive strip PIPS detector in 249Bk+48Ca nuclear reaction is presented too. Case of alpha-alpha correlations is also under brief consideration.

  18. Interaction of transforming growth factor-beta-1 with alpha-2-macroglobulin from normal and inflamed equine joints.


    Coté, N; Trout, D R; Hayes, M. A.


    Binding between equine plasma alpha-2-macroglobulin (alpha 2M) and several cytokines known to participate in inflammatory reactions in other species was initially examined. Plasma was obtained from 5 horses with various abnormalities. Samples, both untreated and after reaction with methylamine, were incubated with exogenous, radiolabeled, porcine-derived transforming growth factor-beta-1 (125I-TGF-beta 1), recombinant human interleukin-1-beta (125I-IL-1 beta), and recombinant human tumor necr...

  19. Workshop on Precision Measurements of $\\alpha_s$

    Energy Technology Data Exchange (ETDEWEB)

    Bethke, Siegfried; /Munich, Max Planck Inst.; Hoang, Andre H.; /Vienna U.; Kluth, Stefan; /Munich, Max Planck Inst.; Schieck, Jochen; /Munich U.; Stewart, Iain W.; Aoki, S.; Beneke, M.; Bethke, S.; Blumlein, J.; Brambilla, N.; Brodsky, S.; /MIT, LNS


    These are the proceedings of the Workshop on Precision Measurements of {alpha}{sub s} held at the Max-Planck-Institute for Physics, Munich, February 9-11, 2011. The workshop explored in depth the determination of {alpha}{sub s}(m{sub Z}) in the {ovr MS} scheme from the key categories where high precision measurements are currently being made, including DIS and global PDF fits, {tau}-decays, electro-weak precision observables and Z-decays, event-shapes, and lattice QCD. These proceedings contain a short summary contribution from the speakers, as well as the lists of authors, conveners, participants, and talks.

  20. Scale Setting for $\\alpha_{s}$ Beyond Leading Order

    CERN Document Server

    Hornbostel, K; Morningstar, C J


    We present a general procedure for applying the scale-setting prescription of Brodsky, Lepage and Mackenzie to higher orders in the strong coupling constant $\\alphas$. In particular, we show how to apply this prescription when the leading coefficient or coefficients in a series in $\\alphas$ are anomalously small. We give a general method for computing an optimum scale numerically, within dimensional regularization, and in cases when the coefficients of a series are known. We find significant corrections to the scales for $R_{e^+ e^-}$, $\\Gamma(B \\to X_u e \\bar{\

  1. Proxima's orbit around Alpha Centauri

    CERN Document Server

    Kervella, P


    Proxima and Alpha Centauri AB have almost identical distances and proper motions with respect to the Sun. Although the probability of such similar parameters is in principle very low, the question whether they actually form a single gravitationally bound triple system has been open since the discovery of Proxima one century ago. Owing to recent high precision radial velocity measurements and the revision of the parameters of the Alpha Cen pair, we show that Proxima and Alpha Cen are gravitationally bound with a high degree of confidence. The orbital period of Proxima is approximately 600 000 years, with a moderate excentricity of 0.42 +0.07 -0.08. Proxima comes within 5.3 -0.9 +1.2 kAU of Alpha Cen at periastron, and the apastron occurs at 12.9 +0.3 -0.1 kAU. This orbital motion may have influenced the formation or evolution of the recently discovered planet orbiting Proxima as well as circumbinary planet formation around Alpha Cen.

  2. An alpha particle detector for a portable neutron generator for the Nuclear Materials Identification System (NMIS) (United States)

    Hausladen, P. A.; Neal, J. S.; Mihalczo, J. T.


    A recoil alpha particle detector has been developed for use in a portable neutron generator. The associated particle sealed tube neutron generator (APSTNG) will be used as an interrogation source for the Nuclear Materials Identification System (NMIS). With the coincident emission of 14.1 MeV neutrons and 3.5 MeV alpha particles produced by the D-T reaction, alpha detection determines the time and direction of the neutrons of interest for subsequent use as an active nuclear materials interrogation source. The alpha particle detector uses a ZnO(Ga) scintillator coating applied to a fiber optic face plate. Gallium-doped zinc oxide is a fast (inorganic scintillator with a high melting point (1975 °C). One detector has been installed in an APSTNG and is currently being tested. Initial results include a measured efficiency for 3.5 MeV alphas of 90%.

  3. Short term integrative meditation improves resting alpha activity and stroop performance. (United States)

    Fan, Yaxin; Tang, Yi-Yuan; Tang, Rongxiang; Posner, Michael I


    Our previous research showed that short term meditation training reduces the time to resolve conflict in the flanker task. Studies also show that resting alpha increases with long term meditation practice. The aim of this study is to determine whether short term meditation training both increases resting alpha activity and reduces the time to resolve conflict in the Stroop task and whether these two effects are related. Forty-three Chinese undergraduates were randomly assigned an experiment group given 5 days meditation training using integrative body-mind training (IBMT) and a relaxation training control. After training, only the IBMT group showed decreased conflict reaction time (RT), and increased resting mean alpha power. Moreover, the higher the enhancement of resting alpha power, the stronger the improvement of conflict RT. The results indicate that short term meditation diffusely enhances alpha and improves the ability to deal with conflict and moreover these two effects are positively related.

  4. Measurement of {sup 17}F+p reactions at RESOLUT

    Energy Technology Data Exchange (ETDEWEB)

    Linhardt, L. E.; Baby, L.; Bardayan, D. W.; Blackmon, J. C.; Gardiner, H.; Johnson, E.; Koschiy, E.; Macon, K. T.; Rasco, B. C.; Rogachev, G.; Santiago-Gonzalez, D.; Wiedenhoever, I. [Department of Physics and Astronomy, Louisiana State University, 202 Nicholson Hall, Tower Dr., Baton Rouge, LA 70803 (United States); Department of Physics, Florida State University, 315 Keen Building, Tallahasse, FL 32306 (United States); Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Department of Physics and Astronomy, Louisiana State University, 202 Nicholson Hall, Tower Dr., Baton Rouge, LA 70803 (United States); Department of Physics, Florida State University, 315 Keen Building, Tallahasse, FL 32306 (United States); Department of Physics and Astronomy, Louisiana State University, 202 Nicholson Hall, Tower Dr., Baton Rouge, LA 70803 (United States); Department of Physics, Florida State University, 315 Keen Building, Tallahasse, FL 32306 (United States)


    The {sup 14}O({alpha},p){sup 17}F reaction is important for understanding the {alpha}p process that occurs in X-ray bursts, but the rate of this reaction remains uncertain due to the uncertain properties of states in {sup 18}Ne. We measured the {sup 17}F(p,p){sup 17}F and {sup 17}F(p,{alpha}){sup 14}O reactions to study the properties of states in {sup 18}Ne that are important for the {sup 14}O({alpha},p){sup 17}F reaction using {sup 17}F radioactive beams from the RESOLUT facility at Florida State University. Double-sided silicon strip detectors were used to detect light particles, and recoiling heavy ions were detected in coincidence using a gas ionization chamber at forward angles. The performance of the system was first tested using the {sup 17}O(p,{alpha}){sup 14}N reaction. This was the first measurement using the ASIC electronics and recoil detector being developed for the Array for Nuclear Astrophysics Studies with Exotic Nuclei (ANASEN). We report on the performance and preliminary results.

  5. The ability of Bipolaris sorokiniana to modify geraniol and (-)-alpha-bisabolol as exogenous substrates. (United States)

    Limberger, R P; Ferreira, L; Castilhos, T; Aleixo, A M; Petersen, R Z; Germani, J C; Zuanazzi, J A; Fett-Neto, A G; Henriques, A T


    The biocatalytic potential of Bipolaris sorokiniana was investigated in its ability to modify the monoterpene geraniol and the sesquiterpene alpha-bisabolol as exogenous substrates, using phosphate buffer as reaction medium. The cultures showed a promising oxidative profile, with conversion of geraniol to 6-methyl-5-hepten-2-one (74.9% yield) in a 5-day incubation and alpha-bisabolol to bisabolol oxide B (84.2% yield), in a 7-day incubation.

  6. Absolute measurement of the $\\beta\\alpha$ decay of $^{16}$N

    CERN Multimedia

    We propose to study the $\\beta$-decay of $^{16}$N at ISOLDE with the aim of determining the branching ratio for $\\beta\\alpha$ decay on an absolute scale. There are indications that the previously measured branching ratio is in error by an amount significantly larger than the quoted uncertainty. This limits the precision with which the S-factor of the astrophysically important $^{12}$C($\\alpha, \\gamma)^{16}$O reaction can be determined.

  7. Bioisosteric phentolamine analogs as selective human alpha(2)- versus alpha(1)-adrenoceptor ligands. (United States)

    Bavadekar, Supriya A; Hong, Seoung-Soo; Lee, Sang-Ii; Miller, Duane D; Feller, Dennis R


    Phentolamine is known to act as a competitive, non-subtype-selective alpha-adrenoceptor antagonist. In an attempt to improve alpha(2)- versus alpha(1)-adrenoceptor selectivity and alpha(2)-adrenoceptor subtype-selectivity, two new chemical series of bioisosteric phentolamine analogs were prepared and evaluated. These compounds were evaluated for binding affinities on alpha(1)- (alpha(1A)-, alpha(1B)-, alpha(1D)-) and alpha(2)- (alpha(2A)-, alpha(2B)-, alpha(2C)-) adrenoceptor subtypes that had been stably expressed in human embryonic kidney and Chinese hamster ovary cell lines, respectively. Methylation of the phenolic hydroxy group and replacement of the 4-methyl group of phentolamine with varying lipophilic substituents yielded bioisosteric analogs selective for the alpha(2)- versus alpha(1)-adrenoceptors. Within the alpha(2)-adrenoceptors, these analogs bound with higher affinity at the alpha(2A)- and alpha(2C)-subtypes as compared to the alpha(2B)-subtype. In particular, the t-butyl analog was found to be the most selective, its binding at the alpha(2C)-adrenoceptor (Ki=3.6 nM) being 37- to 173-fold higher than that at the alpha(1)-adrenoceptors, and around 2- and 19-fold higher than at the alpha(2A)- and alpha(2B)-adrenoceptors, respectively. Data from luciferase reporter gene assays confirmed the functional antagonist activities of selected compounds from the bioisosteric series on human alpha(1A)- and alpha(2C)-adrenoceptors. Thus, the results with these bioisosteric analogs of phentolamine provide a lead to the rational design of potent and selective alpha(2)-adrenoceptor ligands that may be useful in improving the therapeutic profile of this drug class for human disorders.

  8. NACA Physicist Studying Alpha Rays (United States)


    NACA Physicits studying Alpha Rays in a continuous cloud chamber. A cloud chamber is used by Lewis scientists to obtain information aimed at minimizing undesirable effects of radiation on nuclear-powered aircraft components. Here, alpha particles from a polonium source emit in a flower-like pattern at the cloud chamber's center. The particles are made visible by means of alcohol vapor diffusing from an area at room temperature to an area at minus -78 deg. Centigrade. Nuclear-powered aircraft were never developed and aircraft nuclear propulsion systems were canceled in the early 1960s.

  9. Simulating the Lyman Alpha Forest

    CERN Document Server

    Machacek, M E; Anninos, P; Meiksin, A; Norman, M L; Machacek, Marie E.; Bryan, Greg L.; Anninos, Peter; Meiksin, Avery; Norman, Michael L.


    In this paper we review the importance of the Lyman alpha forest as a probe of structure formation in the universe. We first discuss the statistics used to describe the Lyman alpha forest and the numerical techniques used to produce simulated spectra of the forest from a given cosmological model. We then discuss the physical picture of the absorbing structures that emerges from these numerical simulations. Finally, we comment on how two of the statistics, the slope of the column density distribution and the b parameter distribution, may be used to constrain competing cosmologies.

  10. Kinetics of molecular encapsulation of 1-methylcyclopropene into alpha-cyclodextrin. (United States)

    Neoh, Tze Loon; Yamauchi, Kousuke; Yoshii, Hidefumi; Furuta, Takeshi


    1-methylcyclopropene (1-MCP), an ethylene inhibiting regulator, is commercially available in the form of an inclusion complex with alpha-cyclodextrin (alpha-CD). In this study, molecular encapsulation of gaseous 1-MCP into aqueous alpha-CD was investigated in a closed, agitated vessel with a flat gas-liquid interface. Molecular encapsulation of gaseous 1-MCP by alpha-CD is a simultaneous two-step reaction which involves the aqueous dissolution of gaseous 1-MCP and the encapsulation of the dissolved molecules by alpha-CD. The kinetics and mechanism of molecular encapsulation were analyzed based on the depletion rate of 1-MCP in the headspace of the vessel. The encapsulation rates could be explained quantitatively by the gas absorption theory with a pseudo-first-order reaction between 1-MCP and alpha-CD. The negative value of the calculated apparent activation energy of encapsulation (-24.4 kJ/mol) implied the significant effect of exothermic aqueous dissolution of 1-MCP. An encapsulation temperature of 15 degrees C was optimal; at this temperature, the highest 1-MCP yield and best inclusion ratio of inclusion complex were obtained. Changes in the X-ray diffraction pattern suggested that the crystal lattice structure of alpha-CD was altered upon inclusion of 1-MCP.

  11. Angular correlation measurements for 4-{alpha} decaying states in {sup 16}O

    Energy Technology Data Exchange (ETDEWEB)

    Wuosmaa, A.H.; Back, B.B.; Betts, R.R. [and others


    Previous measurements of the {sup 12}C({sup 12}C,{sup 8}Be){sup 16}O{sup *}(4 {alpha}) reaction identified discrete levels in {sup 16}O which decay by breakup into 4 {alpha} particles through a number of different decay sequences, including {sup 16}O{sup *} {yields} {sup 8}Be + {sup 8}Be and {alpha} + {sup 12}C (O{sub 2}{sup +}). These states are observed in a range of excitation energies where resonances are observed in inelastic {alpha} + {sup 12}C scattering leading to the {sup 8}Be + {sup 8}Be and {alpha} + {sup 12}C final states. These resonances were associated with 4 {alpha}-particle chain configurations in {sup 16}O. Should the states populated in the {sup 12}C + {sup 12}C reaction possess this same extended structure, it would serve as an important piece of evidence supporting the idea that even more deformed structures are formed in the {sup 24}Mg compound system. In order to more firmly make this association, it is important to determine the spins of the states populated in the {sup 12}C + {sup 12}C reaction.

  12. Capture reactions on C-14 in nonstandard big bang nucleosynthesis (United States)

    Wiescher, Michael; Gorres, Joachim; Thielemann, Friedrich-Karl


    Nonstandard big bang nucleosynthesis leads to the production of C-14. The further reaction path depends on the depletion of C-14 by either photon, alpha, or neutron capture reactions. The nucleus C-14 is of particular importance in these scenarios because it forms a bottleneck for the production of heavier nuclei A greater than 14. The reaction rates of all three capture reactions at big bang conditions are discussed, and it is shown that the resulting reaction path, leading to the production of heavier elements, is dominated by the (p, gamma) and (n, gamma) rates, contrary to earlier suggestions.

  13. A ruthenium-grafted hydrotalcite as a multifunctional catalyst for direct alpha-alkylation of nitriles with primary alcohols. (United States)

    Motokura, Ken; Nishimura, Daisuke; Mori, Kohsuke; Mizugaki, Tomoo; Ebitani, Kohki; Kaneda, Kiyotomi


    Treatment of a hydrotacite, Mg6Al2(OH)16CO3, with an aqueous solution of RuCl3.nH2O afforded a monomeric Ru(IV) species on the surface of the hydrotalcite. This novel Ru-grafted hydrotalcite (Ru/HT) efficiently catalyzed alpha-alkylation of nitriles with primary alcohols through the cooperative catalysis between the Ru species and the surface base sites. The catalyst system could be further extended for the one-pot synthesis of alpha,alpha-dialkylated phenylacetonitriles via the base-catalyzed Michael reaction of alpha-alkylated phenylacetonitrile with activate olefins.

  14. Two-stream cyclotron radiative instabilities due to the marginally mirror-trapped fraction for fustion alphas in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Arunasalam, V.


    It is shown here that the marginally mirror-trapped fraction of the newly-born fusion alpha particles in the deuterium-tritium (DT) reaction dominated tokamak plasmas can induce a two-stream cyclotron radiative instability for the fast Alfven waves propagating near the harmonics of the alpha particle cyclotron frequency {omega}{sub c{alpha}}. This can explain both the experimentally observed time behavior and the spatially localized origin of the fusion product ion cyclotron emission (ICE) in TFTR at frequencies {omega} {approx} m{omega}{sub c{alpha}}.

  15. The alpha -Process and the r-Process (United States)

    Woosley, S. E.; Hoffman, R. D.


    If material initially in nuclear statistical equilibrium (NSE) at high temperature and containing a large fraction of alpha -particles (or nucleons) is expanded and cooled so rapidly that not all the alpha -particles have time to reassemble, its final composition will differ substantially from what is traditionally calculated for particle-deficient freeze-outs. It has long been known that this phenomenon, the ``alpha -rich freeze-out," can lead to the production of elements heavier than the iron group, but only up to about zinc (A ~ 66). Here we explore the alpha -rich freeze-out for values of neutron excess larger than previously treated and discover nuclear systematics that, for neutron excesses greater than about 0.05, allow the creation of heavier elements all the way up to A ~ 100, even when most of the ejecta is in the form of heavy elements. In the limit of a very large fraction of unassembled alpha -particles and a large neutron excess, the alpha -rich freeze-out merges smoothly into the classical r-process. In contrast to previous studies, we find that a large part of the nuclear flow in the r-process may be carried by charged particle reactions up to about A = 100. We speculate that the site of these processes is the high entropy ``wind'' of a young (age 1-10 s) neutron star in which neutrino energy deposition is driving mass loss. The appropriate conditions exist in the delayed supernova explosion mechanism of Mayle & Wilson, but they may occur in other models as well. The mass of r-process ejected per supernova is expected to be ~ 10(-4) M\\sun \\ per Type II or Type Ib supernova, but this will be sensitive to details of the presupernova structure, the explosion mechanism, and the amount of material that falls back onto the neutron star when the reverse shock arrives there.

  16. Lifetimes of states in 19Ne above the 15 O + alpha breakup threshold

    CERN Document Server

    Mythili, S; Alexander, T K; Ball, G C; Chicoine, M; Chakrawarthy, R S; Churchman, R; Forster, J S; Gujrathi, S; Hackman, G; Howell, D; Kanungo, R; Leslie, J R; Padilla, E; Pearson, C J; Ruiz, C; Ruprecht, G; Schumaker, M A; Tanihata, I; Vockenhuber, C; Walden, P; Yen, S


    The 15O(alpha,gamma)19Ne reaction plays a role in the ignition of Type I x-ray bursts on accreting neutron stars. The lifetimes of states in 19Ne above the 15O + alpha threshold of 3.53 MeV are important inputs to calculations of the astrophysical reaction rate. These levels in 19Ne were populated in the 3He(20Ne,alpha)19Ne reaction at a 20Ne beam energy of 34 MeV. The lifetimes of six states above the threshold were measured with the Doppler shift attenuation method (DSAM). The present measurements agree with previous determinations of the lifetimes of these states and in some cases are considerably more precise.

  17. Inflaton Decay in an Alpha Vacuum

    CERN Document Server

    Naidu, S; Naidu, Siddartha; Holman, Richard


    We study the alpha vacua of de Sitter space by considering the decay rate of the inflaton field coupled to a scalar field placed in an alpha vacuum. We find an {\\em alpha dependent} Bose enhancement relative to the Bunch-Davies vacuum and, surprisingly, no non-renormalizable divergences. We also consider a modified alpha dependent time ordering prescription for the Feynman propagator and show that it leads to an alpha independent result. This result suggests that it may be possible to calculate in any alpha vacuum if we employ the appropriate causality preserving prescription.

  18. Asthma induction in mice leads to appearance of alpha2-3- and alpha2-6-linked sialic acid residues in respiratory goblet-like cells

    DEFF Research Database (Denmark)

    Kirkeby, Svend; Jensen, Niels-Erik Viby; Mandel, Ulla;


    to demonstrate binding of lectins and antibodies that detect alpha2-3- and alpha2-6-linked sialic acid residues. After sensitization and challenge, the histology of the lung changed markedly, and goblet-like cells appeared, most likely caused by Clara cell metaplasia. Normal Clara cells showed no reaction after......Allergic asthmatic inflammation in mice was induced by sensitization with ovalbumin and lipopolysaccharide from Escherichia coli and visualized in the airways of asthmatic mice by spatial and temporal changes of carbohydrates containing sialic acid residues. Immunohistochemistry was used...... incubation with the sialic acid detecting agents, while the goblet-like cells expressed both alpha2-3- and alpha2-6-linked sialic acid residues in the asthmatic animals. The lectins but not the antibodies reacted with intestinal goblet cells. Instead, an antibody recognizing a disialoganglioside, stained...

  19. Ozonolysis of alpha-pinene and beta-pinene: kinetics and mechanism. (United States)

    Zhang, Dan; Zhang, Renyi


    A combined quantum-chemical and RRKM/ME (ME--master equation) approach is employed to investigate the structures, energetics, and kinetics of intermediate and stable species, and the yields of stabilized carbonyl oxides and OH radicals from the alpha-pinene and beta-pinene ozonolysis reactions. The cycloaddition of O(3) is highly exothermic, with the reaction energies of 55.1 and 51.1 kcal mol(-1) for alpha- and beta-pinenes, respectively. Cleavage of primary ozonides yields carbonyl oxides with the barrier height of 12.2-17.5 kcal mol(-1). For the prompt reactions of carbonyl oxides from alpha- and beta-pinene ozonolysis, H migration to hydroperoxides represents the dominant pathway over ring closure to dioxiranes. The kinetic calculations indicate a significant portion of stabilization for alpha- and beta-carbonyl oxides. The yields of stabilized carbonyl oxides are estimated to be 0.34 for alpha-pinene and 0.22 for beta-pinene. The applicability of theoretical methods for investigation of oxidation reactions of large hydrocarbon molecules is demonstrated.

  20. What Powers Lyman alpha Blobs?

    CERN Document Server

    Ao, Y; Beelen, A; Henkel, C; Cen, R; De Breuck, C; Francis, P; Kovacs, A; Lagache, G; Lehnert, M; Mao, M; Menten, K M; Norris, R; Omont, A; Tatemastu, K; Weiss, A; Zheng, Z


    Lyman alpha blobs (LABs) are spatially extended lyman alpha nebulae seen at high redshift. The origin of Lyman alpha emission in the LABs is still unclear and under debate. To study their heating mechanism(s), we present Australia Telescope Compact Array (ATCA) observations of the 20 cm radio emission and Herschel PACS and SPIRE measurements of the far-infrared (FIR) emission towards the four LABs in the protocluster J2143-4423 at z=2.38. Among the four LABs, B6 and B7 are detected in the radio with fluxes of 67+/-17 microJy and 77+/-16 microJy, respectively, and B5 is marginally detected at 3 sigma (51+/-16 microJy). For all detected sources, their radio positions are consistent with the central positions of the LABs. B6 and B7 are obviously also detected in the FIR. By fitting the data with different templates, we obtained redshifts of 2.20$^{+0.30}_{-0.35}$ for B6 and 2.20$^{+0.45}_{-0.30}$ for B7 which are consistent with the redshift of the lyman alpha emission within uncertainties, indicating that both ...

  1. Alpha proton x ray spectrometer (United States)

    Rieder, Rudi; Waeke, H.; Economou, T.


    Mars Pathfinder will carry an alpha-proton x ray spectrometer (APX) for the determination of the elemental chemical composition of Martian rocks and soils. The instrument will measure the concentration of all major and some minor elements, including C, N, and O at levels above typically 1 percent.

  2. Sparse Coding for Alpha Matting. (United States)

    Johnson, Jubin; Varnousfaderani, Ehsan; Cholakkal, Hisham; Rajan, Deepu


    Existing color sampling based alpha matting methods use the compositing equation to estimate alpha at a pixel from pairs of foreground (F) and background (B) samples. The quality of the matte depends on the selected (F,B) pairs. In this paper, the matting problem is reinterpreted as a sparse coding of pixel features, wherein the sum of the codes gives the estimate of the alpha matte from a set of unpaired F and B samples. A non-parametric probabilistic segmentation provides a certainty measure on the pixel belonging to foreground or background, based on which a dictionary is formed for use in sparse coding. By removing the restriction to conform to (F,B) pairs, this method allows for better alpha estimation from multiple F and B samples. The same framework is extended to videos, where the requirement of temporal coherence is handled effectively. Here, the dictionary is formed by samples from multiple frames. A multi-frame graph model, as opposed to a single image as for image matting, is proposed that can be solved efficiently in closed form. Quantitative and qualitative evaluations on a benchmark dataset are provided to show that the proposed method outperforms current state-of-the-art in image and video matting.

  3. Evaluation of a bromine-76-labeled progestin 16{alpha},17{alpha}-dioxolane for breast tumor imaging and radiotherapy: in vivo biodistribution and metabolic stability studies

    Energy Technology Data Exchange (ETDEWEB)

    Zhou Dong; Sharp, Terry L.; Fettig, Nicole M.; Lee, Hsiaoju; Lewis, Jason S. [Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110 (United States); Katzenellenbogen, John A. [Department of Chemistry, University of Illinois, Urbana, IL 61801 (United States); Welch, Michael J. [Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110 (United States)], E-mail:


    Introduction: Progesterone receptors (PRs) are present in many breast tumors, and their levels are increased by certain endocrine therapies. They can be used as targets for diagnostic imaging and radiotherapy. Method: 16{alpha},17{alpha}-[(R)-1'-{alpha}-(5-[{sup 76}Br]Bromofurylmethylidene)dioxyl]-21-hydroxy-19-norpregn-4-ene-3,20-dione ([{sup 76}Br]16{alpha},17{alpha}-[(R)-1'-{alpha}-(5-bromofurylmethylidene)dioxyl]-21-hydroxy-19-norpregn-4-ene-3,20-dione (3)), a PR ligand with relative binding affinity (RBA)=65 and log P{sub o/w}=5.09{+-}0.84, was synthesized via a two-step reaction, and its tissue biodistribution and metabolic stability were evaluated in estrogen-primed immature female Sprague-Dawley rats. Results: [{sup 76}Br]16{alpha},17{alpha}-[(R)-1'-{alpha}-(5-bromofurylmethylidene)dioxyl]-21-hydroxy-19-norpregn-4-ene-3,20-dione 3 was synthesized in 5% overall yield with specific activity being 200-1250 Ci/mmol. [{sup 76}Br]16{alpha},17{alpha}-[(R)-1'-{alpha}-(5-bromofurylmethylidene)dioxyl]-21-hydroxy-19-norpregn-4-ene-3,20-dione 3 demonstrated high PR-mediated uptake in the target tissue uterus (8.72{+-}1.84 %ID/g at 1 h) that was reduced by a blocking dose of unlabeled progestin R5020, but the nonspecific uptake in blood and muscle (2.11{+-}0.14 and 0.89{+-}0.16 %ID/g at 1 h, respectively) was relatively high. [{sup 76}Br]16{alpha},17{alpha}-[(R)-1'-{alpha}-(5-bromofurylmethylidene)dioxyl]-21-hydroxy-19-norpregn-4-ene-3,20-dione 3 was stable in whole rat blood in vitro, but it was not stable in vivo due to the fast metabolism that occurred in the liver, resulting in the formation of a more polar radioactive metabolite and free [{sup 76}Br]bromide. The level of free [{sup 76}Br]bromide in blood remained high during the experiment (2.11{+-}0.14 %ID/g at 1 h and 1.52{+-}0.24 %ID/g at 24 h). The tissue distribution of [{sup 76}Br]16{alpha},17{alpha}-[(R)-1'-{alpha}-(5-bromofurylmethylidene)dioxyl]-21-hydroxy-19-norpregn-4-ene-3

  4. Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia. (United States)

    Weiss, Mitchell J; Zhou, Suiping; Feng, Liang; Gell, David A; Mackay, Joel P; Shi, Yigong; Gow, Andrew J


    Hemoglobin (Hb) synthesis is coordinated by homeostatic mechanisms to limit the accumulation of free alpha or beta subunits, which are cytotoxic. Alpha hemoglobin-stabilizing protein (AHSP) is an abundant erythroid protein that specifically binds free alphaHb, stabilizes its structure, and limits its ability to participate in chemical reactions that generate reactive oxygen species. Gene ablation studies in mice demonstrate that AHSP is required for normal erythropoiesis. AHSP-null erythrocytes are short-lived, contain Hb precipitates, and exhibit signs of oxidative damage. Loss of AHSP exacerbates beta-thalassemia in mice, indicating that altered AHSP expression or function could modify thalassemia phenotypes in humans, a topic that is beginning to be explored in clinical studies. We used biochemical, spectroscopic, and crystallographic methods to examine how AHSP stabilizes alphaHb. AHSP binds the G and H helices of alphaHb on a surface that largely overlaps with the alpha1-beta1 interface of HbA. This result explains previous findings that betaHb can competitively displace AHSP from alphaHb to form HbA tetramer. Remarkably, binding of AHSP to oxygenated alphaHb induces dramatic conformational changes and converts the heme-bound iron to an oxidized hemichrome state in which all six coordinate positions are occupied. This structure limits the reactivity of heme iron, providing a mechanism by which AHSP stabilizes alphaHb. These findings suggest a biochemical pathway through which AHSP might participate in normal Hb synthesis and modulate the severity of thalassemias. Moreover, understanding how AHSP stabilizes alphaHb provides a theoretical basis for new strategies to inhibit the damaging effects of free alphaHb that accumulates in beta-thalassemia.

  5. Inclusive-jet photoproduction at HERA and determination of alphas

    CERN Document Server

    Abramowicz, H


    Inclusive-jet cross sections have been measured in the reaction ep->e+jet+X for photon virtuality Q2 17 GeV and -1 < etajet < 2.5. In addition, measurements of double-differential inclusive-jet cross sections are presented as functions of ETjet in different regions of etajet. Next-to-leading-order QCD calculations give a good description of the measurements, except for jets with low ETjet and high etajet. The influence of non-perturbative effects not related to hadronisation was studied. Measurements of the ratios of cross sections using different jet algorithms are also presented; the measured ratios are well described by calculations including up to O(alphas2) terms. Values of alphas(Mz) were extracted from the measurements and the energy-scale dependence of the coupling was determined. The value of alphas(Mz) extracted from the measurements based on the kT jet algorithm is alphas(Mz) = 0.1206 +0.0023 -0.0022 (exp.) +0.0042 -0.0035 (th.); the results from the anti-kT and SIScone algorithms are compat...

  6. Enzymic synthesis of alpha- and beta-D-glucosides of 1-deoxynojirimycin and their glycosidase inhibitory activities. (United States)

    Asano, N; Oseki, K; Kaneko, E; Matsui, K


    1-Deoxynojirimycin (1) is a potent inhibitor of mammalian and rice alpha-glucosidase. Several glucosides of 1 were synthesized by use of the native and immobilized enzyme and their effect on various enzymes was investigated. Transglucosylation reactions using rice alpha-glucosidase, yeast alpha- and beta-glucosidases purified from Rhodotorula lactosa were performed with maltose or cellobiose as a glucose donor and N-(benzyloxycarbonyl)-1-deoxynojirimycin (2) as an acceptor. The transglucosylation reaction using native rice alpha-glucosidase afforded 3-O-alpha-D-glucopyranosyl-N-(benzyloxycarbonyl)-1-deoxynojirimycin (4), 4-O-alpha-D-glucopyranosyl-N-(benzyloxycarbonyl)-1-deoxynojirimycin (5), and 2-O-alpha-D-glucopyranosyl-N-(benzyloxycarbonyl)-1-deoxynojirimycin (3) in yields of 40, 13, and 2%, respectively, after 30 min. The transglucosylation reaction using immobilized rice alpha-glucosidase was similar to that using the native enzyme. In the system using native yeast alpha-glucosidase, 3, 5, and 4 were formed in yields of 34, 13, and 6%, respectively, after 15 h. The immobilization of yeast alpha-glucosidase caused a significant decrease in transglucosylation activity. Yeast beta-glucosidase showed a high transglucosylation activity and incubation with the reaction system afforded 2-O-beta-D-glucopyranosyl-N-(benzyloxycarbonyl)-1-deoxynojirimycin (6) and 4-O-beta-D-glucopyranosyl-N-(benzyloxycarbonyl)-1-deoxynojirimycin (7) in yields of 69 and 3%, respectively, after 3 h. The transglucosylation reaction using immobilized yeast beta-glucosidase preferentially afforded 6 in a yield of 73% after 3 h. After removal of N-benzyloxycarbonyl group from the product glucosides, their glycosidase inhibitory activities were measured. 3-O-alpha-D-Glucopyranosyl-1-deoxynojirimycin (9) retained the potent inhibition of 1 against rat intestinal sucrase activity and was more effective than 1 against rice alpha-glucosidase. 4-O-alpha-D-Glucopyranosyl-1-deoxynojirimycin (10

  7. T-cell receptor V sub. alpha. and C sub. alpha. alleles associated with multiple sclerosis and myasthenia gravis

    Energy Technology Data Exchange (ETDEWEB)

    Oksenberg, J.R.; Cavalli-Sforza, L.L.; Steinman, L. (Stanford Univ., CA (USA)); Sherritt, M.; Bernard, C.C. (LaTrobe Univ., Victoria (Australia)); Begovich, A.B.; Erlich, H.A. (Cetus Corporation, Emeryville, CA (USA))


    Polymorphic markers in genes encoding the {alpha} chain of the human T-cell receptor (TcR) have been detected by Southern blot analysis in Pss I digests. Polymorphic bands were observed at 6.3 and 2.0 kilobases (kb) with frequencies of 0.30 and 0.44, respectively, in the general population. Using the polymerase chain reaction (PCR) method, the authors amplified selected sequences derived from the full-length TcR {alpha} cDNA probe. These PcR products were used as specific probes to demonstrate that the 6.3-kb polymorphic fragment hybridizes to the variable (V)-region probe and the 2.0-kb fragment hybridizes to the constant (C)-region probe. Segregation of the polymorphic bands was analyzed in family studies. To look for associations between these markers and autoimmune diseases, the authors have studied the restriction fragment length polymorphism distribution of the Pss I markers in patients with multiple sclerosis, myasthenia gravis, and Graves disease. Significant differences in the frequency of the polymorphic V{sub {alpha}} and C{sub {alpha}} markers were identified between patients and healthy individuals.

  8. Evolution and seismology of alpha Centauri

    CERN Document Server

    Montalban, J; Montalban, Josefina; Miglio, Andrea


    Solar-like oscillations detected in both components of the binary system alpha Centauri provide strong constraints on the fundamental parameters of the stellar system. We model alpha Centauri by means of a Levenberg-Marquardt minimization algorithm including seismic and classical constraints. Computations, that were perfomed decreasing significanly the weight of alpha Cen B seismic data in the calibration procedure, predict small separations in good agreement with new observations of solar-like oscillations in alpha Cen B by Bedding (these proceedings).

  9. Thermodynamics of the hydrolysis reactions of nitriles

    Energy Technology Data Exchange (ETDEWEB)

    Tewari, Yadu B. [Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States)]. E-mail:; Goldberg, Robert N. [Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States)]. E-mail:


    Microcalorimetry and high-performance liquid chromatography (h.p.l.c) have been used to conduct a thermodynamic investigation of the following nitrilase catalyzed reactions: (1) benzonitrile(aq) + 2H{sub 2}O(l) = benzoic acid(aq) + ammonia(aq), (2) benzylcyanide(aq) + 2H{sub 2}O(l) = benzeneacetic acid(aq) + ammonia(aq) (3) 3-phenylpropionitrile(aq) + 2H{sub 2}O(l) 3-phenylpropanoic acid(aq) + ammonia(aq), (4) 4-phenylbutyonitrile(aq) + 2H{sub 2}O(l) = 4-phenylbutyric acid(aq) + ammonia(aq), (5) {alpha}-methylbenzyl cyanide(aq) + 2H{sub 2}O(l) = {alpha}-methylbenzene acetic acid(aq) + ammonia(aq), and (6) 3-indoleacetonitrile(aq) + 2H{sub 2}O(l) = indole-3-acetic acid(aq) + ammonia(aq). The equilibrium measurements showed that these reactions proceeded to completion. Thus, it was possible to set only lower limits for the values of the apparent equilibrium constants K'. However, it was possible to obtain precise values of the calorimetrically determined molar enthalpies of reaction {delta}{sub r} H {sub m}(cal). These values were then used in conjunction with an equilibrium model to calculate values of the standard molar enthalpies for chemical reference reactions that correspond to the above overall biochemical reactions.


    NARCIS (Netherlands)



    We have identified a new protein fold-the alpha/beta-hydrolase fold-that is common to several hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is similar: an alpha/beta-sheet, not barrel, of eight beta-sheets connected by alpha-helices. These

  11. Effectiveness of Alpha Biofeedback Therapy: Negative Results. (United States)

    Watson, Charles G.; Herder, Joseph


    Assessed the utility of alpha biofeedback training in the treatment of patients (N=66). Biofeedback and placebo biofeedback groups were given alpha or mock-alpha training sessions. Improvement on 54 variables was compared to that of no-treatment controls. Only a chance number of significant changes appeared among the groups. (Author)

  12. Enzyme replacement therapy for alpha-mannosidosis

    DEFF Research Database (Denmark)

    Borgwardt, Line Gutte; Dali, Christine I.; Fogh, J


    Alpha-mannosidosis (OMIM 248500) is a rare lysosomal storage disease (LSD) caused by alpha-mannosidase deficiency. Manifestations include intellectual disabilities, facial characteristics and hearing impairment. A recombinant human alpha-mannosidase (rhLAMAN) has been developed for weekly intrave...... intravenous enzyme replacement therapy (ERT). We present the preliminary data after 12 months of treatment....

  13. Inhibition of tumour necrosis factor-alpha (TNF-alpha) release from mast cells by the anti-inflammatory drugs, sodium cromoglycate and nedocromil sodium. (United States)

    Bissonnette, E Y; Enciso, J A; Befus, A D


    TNF-alpha is a cytokine thought to be involved in the pathogenesis of asthma and in several other inflammatory conditions. Given recent evidence that mast cells (MC) are an important source of TNF-alpha, we investigated the effects of two anti-inflammatory drugs, nedocromil sodium (NED) and sodium cromoglycate (SCG), on rat MC-derived TNF-alpha. We established that at least 2 h pretreatment with NED or SCG followed by washing was required to inhibit TNF-alpha-dependent cytotoxicity by rat peritoneal MC (PMC). A maximum inhibition of TNF-alpha occurred after 6 h treatment. The inhibitory effect of NED and SCG (10(-5)-10(-3)M) was concentration-dependent (20-37% for NED and 16-37% for SCG). The time-course analysis and the use of cycloheximide, an inhibitor of protein synthesis, provided strong evidence that new protein synthesis by the MC is required for this inhibitory effect. Furthermore, 24 h treatment with 1 mM NED inhibited the levels of mRNA for TNF-alpha by 59-83%. In addition to the effect on TNF-alpha-dependent cytotoxicity by MC, 20 min pretreatment with 10(-4) M NED and SCG inhibited antigen-stimulated TNF-alpha release (6h) by 42% and 48%, respectively. Interestingly, the functionally distinct intestinal mucosal MC (IMMC) is unresponsive to these drugs with regard to histamine secretion. However, as with PMC, 2h pretreatment with NED or SCG inhibited TNF-alpha-dependent cytotoxicity by IMMC. These effects may be important in the action of these drugs in vivo in the late phase reaction in asthma or other inflammatory conditions. Images Fig. 6 PMID:7554404

  14. Refinement of the $n-\\alpha$ and $p-\\alpha$ fish-bone potential

    CERN Document Server

    Smith, E; Papp, Z


    The fishbone potential of composite particles simulates the Pauli effect by nonlocal terms. We determine the $n-\\alpha$ and $p-\\alpha$ fish-bone potential by simultaneously fitting to the experimental phase shifts. We found that with a double Gaussian parametrization of the local potential can describe the $n-\\alpha$ and $p-\\alpha$ phase shifts for all partial waves.

  15. Nature of the pygmy dipole resonance in Ce-140 studied in (alpha, alpha 'gamma) experiments

    NARCIS (Netherlands)

    Savran, D.; Babilon, M.; van den Berg, A. M.; Harakeh, M. N.; Hasper, J.; Matic, A.; Wortche, H. J.; Zilges, A.


    A concentration of electric-dipole excitations below the particle threshold, which is frequently denoted as the pygmy dipole resonance, has been studied in the semimagic nucleus Ce-140 in (alpha, alpha(')gamma) experiments at E-alpha=136 MeV. The technique of alpha-gamma coincidence experiments allo

  16. Cationization of Alpha-Cellulose to Develop New Sustainable Products

    Directory of Open Access Journals (Sweden)

    Ana Moral


    Full Text Available Papermaking has been using high quantities of retention agents, mainly cationic substances and organic compounds such as polyamines. The addition of these agents is related to economic and environmental issues, increasing contamination of the effluents. The aim of this work is to develop a cationic polymer for papermaking purposes based on the utilization of alpha-cellulose. The cationization of mercerized alpha-cellulose with 3-chloro-2-hydroxypropyltrimethylammonium chloride (CHPTAC is governed by a pseudo-second-order reaction. The initial amorphous fraction of cellulose is reacted with CHPTAC until the equilibrium value of nitrogen substitution is reached. Nitrogen is incorporated as a quaternary ammonium group in the polymer. Also, the kinetic constant increased with decreasing crystallinity index, showing the importance of the previous alkalization stage. The use of modified natural polysaccharides is a sustainable alternative to synthetic, nonbiodegradable polyelectrolytes and thus is desirable with a view to developing new products and new processes.

  17. Separation of the subtypes of type V collagen molecules, [alpha 1(V)]2 alpha 2(V) and alpha 1(V) alpha 2(V) alpha 3(V), by chain composition-dependent affinity for heparin: single alpha 1(V) chain shows intermediate heparin affinity between those of the type V collagen subtypes composed of [alpha 1(V)]2 alpha 2(V) and of alpha 1(V) alpha 2(V) alpha 3(V). (United States)

    Mizuno, K; Hayashi, T


    The heparin affinities of heat-treated type V collagen alpha-chains and the triple-helical molecules were evaluated in terms of the NaCl concentration required for prevention of binding to a heparin-Sepharose column. After heat treatment, alpha 1(V) chain required approximately two-fold higher NaCl concentration to pass through the column than the other two chains, alpha 2(V) and alpha 3(V). Thus, the heparin affinity of alpha 1(V) may be approximately two-fold higher than those of the other alpha (V)-chains. The type V collagen molecules in triple-helical conformation were separated into two fractions at 170 mM NaCl in 20 mM phosphate buffer, pH 7.2, containing 2 M urea; bound and non-bound. The ratio of the three alpha-chains, alpha 1(V): alpha 2(V): alpha 3(V) was 2 : 1 : 0 and 1 : 1 : 1 in the bound and flow-through fractions, respectively, on analysis by SDS-PAGE. The differential affinity of the two fractions could be accounted for by the number of alpha 1(V) chains in the triple-helical molecule, if these fractions contained triple-helical subtypes with the chain compositions of [alpha 1(V)]2 alpha 2(V) and alpha 1(V) alpha 2(V) alpha 3(V), respectively. From the comparison of the NaCl concentration required for prevention of the binding, [alpha 1(V)]2, alpha 2(V) had about two-fold higher affinity than alpha 1(V) alpha 2(V) alpha 3(V), and the separated alpha 1(V) chain showed an intermediate affinity. A possible explanation for difference in heparin affinity among the subtypes of molecules and the separated alpha-chains is that the heparin affinity of type V collagen molecule is governed by the number of alpha 1(V) chains contained in the molecule and that steric restraint in a triple-helical conformation weakens the binding of alpha 1(V) chain to heparin.

  18. Theoretical Calculations and Analysis for n+59Co Reaction up to 20 MeV

    Institute of Scientific and Technical Information of China (English)


    <正>All cross-sections of neutron-induced reactions, angular distributions, double differential cross sections, and energy spectra for neutron, proton, deuteron, triton, helium and alpha-particle emissions are

  19. Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution

    NARCIS (Netherlands)

    Kelly, Ronan M.; Leemhuis, Hans; Rozeboom, Henriette J.; van Oosterwijk, Niels; Dijkstra, Bauke W.; Dijkhuizen, Lubbert


    Thermoanaerobacterium thermosulfurigenes cyclodextrin glucanotransferase primarily catalyses the formation of cyclic alpha-(1,4)-linked oligosaccharides (cyclodextrins) from starch. This enzyme also possesses unusually high hydrolytic activity as a side reaction, thought to be due to partial retenti

  20. Crystalline anhydrous {alpha},{alpha}-trehalose (polymorph {beta}) and crystalline dihydrate {alpha},{alpha}-trehalose: A calorimetric study

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Susana S. [Centro de Quimica Estrutural, Complexo Interdisciplinar, Instituto Superior Tecnico, 1049-001 Lisbon (Portugal)]. E-mail:; Diogo, Herminio P. [Centro de Quimica Estrutural, Complexo Interdisciplinar, Instituto Superior Tecnico, 1049-001 Lisbon (Portugal)]. E-mail:; Moura-Ramos, Joaquim J. [Centro de Quimica-Fisica Molecular, Complexo Interdisciplinar, Instituto Superior Tecnico, 1049-001 Lisbon (Portugal)]. E-mail:


    The mean values of the standard massic energy of combustion of crystalline anhydrous {alpha},{alpha}-trehalose (C{sub 12}H{sub 22}O{sub 11}, polymorph {beta}) and crystalline dihydrate {alpha},{alpha}-trehalose (C{sub 12}H{sub 26}O{sub 13}) measured by static-bomb combustion calorimetry in oxygen, at the temperature T=298.15K, are {delta}{sub c}u{sup o}=-(16434.05+/-4.50)J.g{sup -1} and {delta}{sub c}u{sup o}=-(14816.05+/-3.52)J.g{sup -1}, respectively. The standard (p{sup o}=0.1MPa) molar enthalpy of formation of these compounds were derived from the corresponding standard molar enthalpies of combustion, respectively, {delta}{sub f}H{sub m}{sup o} (C{sub 12}H{sub 22}O{sub 11},cr)=-(2240.9+/-3.9)kJ.mol{sup -1}, and {delta}{sub f}H{sub m}{sup o} (C{sub 12}H{sub 26}O{sub 13},cr)=-(2832.6+/-3.6)kJ.mol{sup -1}. The values of the standard enthalpies of formation obtained in this work, together with data on enthalpies of solution at infinite dilution ({delta}{sub sol}H{sup {approx}}) for crystalline dihydrate and amorphous anhydrous trehalose, allow a better insight on the thermodynamic description of the trehalose system which can provide, together with the future research on the subject, a contribution for understanding the metabolism in several organisms, as well as the phase transition between the different polymorphs.

  1. Straightforward synthesis of alpha,beta-unsaturated thioesters via ruthenium-catalyzed olefin cross-metathesis with thioacrylate

    NARCIS (Netherlands)

    van Zijl, Anthoni W.; Minnaard, Adriaan J.; Feringa, Ben L.


    The cross-metathesis reaction of S-ethyl thioacrylate with a variety of olefins is effectively catalyzed by using a ruthenium benzylidene olefin metathesis catalyst. This reaction provides a convenient and versatile route to substituted alpha,beta-unsaturated thioesters, key building blocks in organ

  2. Silver(I) triflate-catalyzed direct synthesis of N-PMP protected alpha-aminopropargylphosphonates from terminal alkynes. (United States)

    Dodda, Rajasekhar; Zhao, Cong-Gui


    [reaction: see text] N-PMP protected alpha-aminopropargylphosphonates have been synthesized by using a silver(I) triflate-catalyzed one-pot three-component reaction of terminal alkynes, p-anisidine, and diethyl formylphosphonate hydrate. Good to excellent yields of the desired products may be obtained with a very simple procedure.

  3. Alpha voltaic batteries and methods thereof (United States)

    Raffaelle, Ryne P. (Inventor); Jenkins, Phillip (Inventor); Wilt, David (Inventor); Scheiman, David (Inventor); Chubb, Donald (Inventor); Castro, Stephanie (Inventor)


    An alpha voltaic battery includes at least one layer of a semiconductor material comprising at least one p/n junction, at least one absorption and conversion layer on the at least one layer of semiconductor layer, and at least one alpha particle emitter. The absorption and conversion layer prevents at least a portion of alpha particles from the alpha particle emitter from damaging the p/n junction in the layer of semiconductor material. The absorption and conversion layer also converts at least a portion of energy from the alpha particles into electron-hole pairs for collection by the one p/n junction in the layer of semiconductor material.

  4. Diagnosis of alpha-1-antitrypsin deficiency by DNA analysis of children with liver disease

    Directory of Open Access Journals (Sweden)

    De TOMMASO Adriana Maria Alves


    Full Text Available Background - Alpha-1-antitrypsin deficiency is a genetic disorder which is transmitted in a co-dominant, autosomal form. Alpha-1-antitrypsin deficiency affects mainly the lungs and the liver leading, in the latter case, to neonatal cholestasis, chronic hepatitis or cirrhosis. A precise diagnosis of Alpha-1-antitrypsin deficiency may be obtained by biochemical or molecular analysis. Objective - The purpose of this study was to use DNA analysis to examine the presence of an alpha-1-antitrypsin deficiency in 12 children suspected of having this deficiency and who showed laboratory and clinical characteristics of the disease. Patients and Methods - Twelve patients, aged 3 months to 19 years, who had serum alpha-1-antitrypsin levels lower than normal and/or had hepatic disease of undefined etiology were studied. The mutant alleles S and Z of the alpha-1-antitrypsin gene were investigated in the 12 children. Alpha-1-antitrypsin gene organization was analyzed by amplification of genoma through the polymerase chain reaction and digestion with the restriction enzymes Xmnl (S allele and Taq 1 (Z allele. Results - Seven of the 12 patients had chronic liver disease of undefined etiology and the other five patients had low serum levels of alpha-1-antitrypsin as well as a diagnosis of neonatal cholestasis and/or chronic liver disease of undefined etiology. Five of the 12 patients were homozygous for the Z allele (ZZ and two had the S allele with another allele (*S different from Z. Conclusion - These results show that alpha-1-antitrypsin deficiency is relatively frequent in children with chronic hepatic disease of undefined etiology and/or low alpha-1-antitrypsin levels (41.6%. A correct diagnosis is important for effective clinical follow-up and for genetic counseling.

  5. Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans. (United States)

    Lochrie, M A; Mendel, J E; Sternberg, P W; Simon, M I


    A cDNA corresponding to a known G protein alpha subunit, the alpha subunit of Go (Go alpha), was isolated and sequenced. The predicted amino acid sequence of C. elegans Go alpha is 80-87% identical to other Go alpha sequences. An mRNA that hybridizes to the C. elegans Go alpha cDNA can be detected on Northern blots. A C. elegans protein that crossreacts with antibovine Go alpha antibody can be detected on immunoblots. A cosmid clone containing the C. elegans Go alpha gene (goa-1) was isolated and mapped to chromosome I. The genomic fragments of three other C. elegans G protein alpha subunit genes (gpa-1, gpa-2, and gpa-3) have been isolated using the polymerase chain reaction. The corresponding cosmid clones were isolated and mapped to disperse locations on chromosome V. The sequences of two of the genes, gpa-1 and gpa-3, were determined. The predicted amino acid sequences of gpa-1 and gpa-3 are only 48% identical to each other. Therefore, they are likely to have distinct functions. In addition they are not homologous enough to G protein alpha subunits in other organisms to be classified. Thus C. elegans has G proteins that are identifiable homologues of mammalian G proteins as well as G proteins that appear to be unique to C. elegans. Study of identifiable G proteins in C. elegans may result in a further understanding of their function in other organisms, whereas study of the novel G proteins may provide an understanding of unique aspects of nematode physiology. Images PMID:1907494

  6. [Substrate specificity of Cryptococcus albidus and Eupenicillium erubescens alpha-L-rhamnosidases]. (United States)

    Hudzenko, O V; Varbanets', L D


    The substrate specificity of Cryptococcus albidus and Eupenicillium erubescens alpha-L-rhamnosidases has been investigated. It is shown that the enzymes are able to act on synthetic and natural substrates, such as naringin, neohesperidin. alpha-L-Rhamnosidases hydrolysed the latter ones very efficiently, in this case E. erubescens enzyme was characterized by higher values of V(max) in comparison with the enzyme of C. albidus. However the C. albidus alpha-L-rhamnosidase showed greater affinity for naringin and neohesperidin than the enzyme of E. erubescens (K(m) 0.77 and 3.3 mM and 5.0 and 3.0 mM, respectively). As regards the synthetic derivatives of monosaccharides, both enzymes exhibited narrow specificity for glycon: E. erubescens alpha-L-rhamnosidase--only to the p-nitrophenyl-alpha-L-rhamnopiranoside (K(m) 1.0 mM, V(max) 120 micromol/min/mg protein), and C. albidus--to p-nitrophenyl-alpha-D-glucopyranoside (K(m) 10 mM, V(max) 5 micromol/min/mg protein). Thus, it was found that the enzyme preparations of E. erubescens and C. albidus are differed by their substrate specificity. The ability of E. erubescens and C. albidus alpha-L-rhamnosidases to hydrolyse natural substrates: naringin and neohesperidin, evidences for their specificity for alpha-1,2-linked L-rhamnose. Based on these data, we can predict the use of E. erubescens and C. albidus alpha-L-rhamnosidases in various industries, food industry in particular. This is also confirmed by the fact that the investigated alpha-L-rhamnosidases were stable at 20% concentration of ethanol and 500 mM glucose in the reaction mixture.

  7. Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches



    Collagen IV is a major component of vertebrate basal laminae (BLs). Studies in humans have revealed a family of genes encoding alpha 1- alpha 6 collagen IV chains and implicated alpha 3-alpha 6 in disease processes (Goodpasture and Alport syndromes and diffuse leiomyomatosis). To extend studies of these components to an experimentally accessible animal, we cloned cDNAs encoding partial collagen alpha 3, alpha 4, and alpha 5(IV) chains from the mouse. Ribonuclease protection assays showed that...

  8. Synthesis and characterization of ring-like {alpha}-Fe{sub 2}O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Li Lili; Chu Ying; Liu Yang [Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024 (China)


    A novel ring-like {alpha}-Fe{sub 2}O{sub 3} with a cave at the centre was first synthesized via the redox reaction of Fe{sup 2+} with S{sub 2}O{sub 8}{sup 2-} in solution. The samples were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), x-ray diffraction (XRD) and vibrating sample magnetometry (VSM). The possible mechanisms of shape evolution for the formation of ring-like {alpha}-Fe{sub 2}O{sub 3} were discussed. Magnetic hysteresis measurements revealed that the ring-like {alpha}-Fe{sub 2}O{sub 3} display a magnetic behaviour with a coercivity of 1690 Oe at room temperature. The photocatalytic degradation of salicylic acid revealed that ring-like {alpha}-Fe{sub 2}O{sub 3} exhibits a photocatalytic property.

  9. Antisymmetry and channel coupling contributions to the absorption for $p + \\alpha /d + ^{3}He$

    CERN Document Server

    Cooper, S G


    To understand recently established empirical p + alpha potentials, RGM calculations followed by inversion are made to study contributions of the d + 3He reaction channels and deuteron distortion effects to the p + alpha potential. An equivalent study of the d + 3He potential is also presented. The contributions of exchange non-locality to the absorption are simulated by including an phenomenological imaginary potential in the RGM. These effects alone strongly influence the shape of the imaginary potentials for both p + alpha and d + 3He. The potentials local-equivalent to the fully antisymmetrised-coupled channels calculations have a significant parity-dependence in both real and imaginary components, which for p + alpha is qualitatively similar to that found empirically. The effects on the potentials of the further inclusion of deuteron distortion are also presented. The inclusion of a spin-orbit term in the RGM, adds additional terms to the phase-equivalent potential, most notably the comparatively large im...

  10. Astrophysical S factor for {alpha}-capture on {sup 115}Sn

    Energy Technology Data Exchange (ETDEWEB)

    Filipescu, D.; Cata-Danil, I.; Ivascu, M.; Bucurescu, D.; Zamfir, N.V.; Glodariu, T.; Stroe, L.; Mihai, C.; Marginean, N.; Ghita, D.G.; Marginean, R.; Suliman, G.; Sava, T.; Pascu, S. [Horia-Hulubei National Institute for Physics and Nuclear Engineering, Magurele-Ilfov (Romania); Cata-Danil, G. [Physics Department, University Politehnica, Bucharest (Romania)


    The s and r processes calculations can only account for 50% of the {sup 115}Sn abundance, and recent p process calculations cannot explain the remaining fraction. For this reason, the experimental measurement of the S factor of {alpha} capture on {sup 115}Sn is of high importance in explaining the origin of {sup 115}Sn. The cross section of {sup 115}Sn({alpha}, {gamma}){sup 119}Te reaction has been measured in the effective center of mass energy from 9.5 to 14.7 MeV. Enriched self-supporting {sup 115}Sn (56%) foils were bombarded with {alpha} beam delivered by the Bucharest IFIN-HH Tandem Accelerator. The induced activity of {sup 119}Te was measured with two large volume GeHP detectors in close geometry to maximize the detector efficiency. The experimental cross section and astrophysical S factor are compared with statistical model predictions for different global {alpha}-nucleus optical potential.

  11. Measurement of the branching ratio for beta-delayed alpha decay of 16N

    CERN Document Server

    Refsgaard, J; Dijck, E A; Fynbo, H O U; Lund, M V; Portela, M N; Raabe, R; Randisi, G; Renzi, F; Sambi, S; Sytema, A; Willmann, L; Wilschut, H W


    While the 12C(a,g)16O reaction plays a central role in nuclear astrophysics, the cross section at energies relevant to hydrostatic helium burning is too small to be directly measured in the laboratory. The beta-delayed alpha spectrum of 16N can be used to constrain the extrapolation of the E1 component of the S-factor; however, with this approach the resulting S-factor becomes strongly correlated with the assumed beta-alpha branching ratio. We have remeasured the beta-alpha branching ratio by implanting 16N ions in a segmented Si detector and counting the number of beta-alpha decays relative to the number of implantations. Our result, 1.49(5)e-5, represents a 25% increase compared to the accepted value and implies an increase of 14% in the extrapolated S-factor.

  12. Analysis of radiation risk from alpha particle component of solar particle events (United States)

    Cucinotta, F. A.; Townsend, L. W.; Wilson, J. W.; Golightly, M. J.; Weyland, M.


    The solar particle events (SPE) will contain a primary alpha particle component, representing a possible increase in the potential risk to astronauts during an SPE over the often studied proton component. We discuss the physical interactions of alpha particles important in describing the transport of these particles through spacecraft and body shielding. Models of light ion reactions are presented and their effects on energy and linear energy transfer (LET) spectra in shielding discussed. We present predictions of particle spectra, dose, and dose equivalent in organs of interest for SPE spectra typical of those occurring in recent solar cycles. The large events of solar cycle 19 are found to have substantial increase in biological risk from alpha particles, including a large increase in secondary neutron production from alpha particle breakup.

  13. Further Precise Determinations of $\\alpha_s$ from Lattice QCD

    CERN Document Server

    Davies, C T H; Lepage, G P; McCallum, P; Shigemitsu, J; Sloan, J


    We present a new determination of the strong coupling constant from lattice QCD simulations. We use four different short-distance quantities to obtain the coupling, three different (infrared) meson splittings to tune the simulation parameters, and a wide range of lattice spacings, quark masses, and lattice volumes to test for systematic errors. Our final result consists of ten different determinations of $\\alpha^{(3)}_{P}(8.2 GeV)$, which agree well with each other and with our previous results. The most accurate of these, when evolved perturbatively to the $Z^0$ mass, gives obtained from other recent lattice simulations.

  14. Double-real corrections at O(alpha alpha_s) to single gauge boson production

    CERN Document Server

    Bonciani, Roberto; Mondini, Roberto; Vicini, Alessandro


    We consider the O(alpha alpha_s) corrections to single on-shell gauge boson production at hadron colliders. We concentrate on the contribution of all the subprocesses where the gauge boson is accompanied by the emission of two additional real partons and we evaluate the corresponding total cross sections. The latter are divergent quantities, because of soft and collinear emissions, and are expressed as Laurent series in the dimensional regularization parameter. The total cross sections are evaluated by means of reverse unitarity, i.e. expressing the phase-space integrals in terms of two-loop forward box integrals with cuts on the final state particles. The results are reduced to a combination of Master Integrals, which eventually are evaluated in terms of Generalized Polylogarithms. The presence of internal massive lines in the Feynman diagrams, due to the exchange of electroweak gauge bosons, causes the appearance of 14 Master Integrals which were not previously known in the literature and have been evaluate...

  15. Photolysis of hop-derived trans-iso-alpha-acids and trans-tetrahydroiso-alpha-acids: product identification in relation to the lightstruck flavour of beer. (United States)

    Heyerick, Arne; Zhao, Yining; Sandra, Pat; Huvaere, Kevin; Roelens, Frederik; De Keukeleire, Denis


    The photolysis of hop-derived trans-iso-alpha-acids (2a-c; naturally occurring bitter compounds present in beer) and of trans-tetrahydroiso-alpha-acids (5a-c; semi-synthetic advanced hop products) was investigated at 300 nm in methanol. The complex photoreaction mixtures were separated by high-performance liquid chromatography (HPLC) using diode array detection and the major photoreaction products were identified by HPLC-mass spectroscopy. The main part of the mixture consisted of compounds, which originated from recombination of radicals derived from Norrish Type I photocleavage of the acyloin moiety in both trans-iso-alpha-acids and trans-tetrahydroiso-alpha-acids. The results confirm the intermediacy of radicals that were previously identified by time-resolved electron paramagnetic resonance and they bear relevance to the formation of the lightstruck flavour that is generated when beer is exposed to light. Additionally, new photoproducts were found that are formed by photochemical reactions hitherto undiscovered in hop chemistry, including photoenolization of trans-isohumulone (2a) leading to trans-alloisohumulone (13a) and a retro oxa-di-pi-methane rearrangement in trans-isohumulone (2a) and trans-tetrahydroiso-alpha-acids to humulone (1a) and tetrahydro-alpha-acids (23a-b), respectively.

  16. {sup 10}Be({alpha},n){sup 13}C angular distribution measurements

    Energy Technology Data Exchange (ETDEWEB)

    Guillemette, J.; Massey, T.N.; O`Donnell, J.E.; Saito, E.F.; Lane, R.O. [Ohio Univ., Athens, OH (United States)


    As a continuation of our investigation of the {sup 14}C system, {sup 10}Be targets have been bombarded with a pulsed beam of alpha particles from the Ohio University Tandem Accelerator. The {sup 10}Be target is in the form of {sup 10}BeO (92 {mu}g/cm{sup 2}) deposited on a platinum foil. Neutron time-of-flight spectra were produced with the Beam Swinger facility and a 4.88 in flight path. Fifty-four neutron angular distributions for the {sup 10}Be({alpha},n{sub {circ}}){sup 13}C and {sup 10}Be({alpha},n{sub 1}){sup 13}C reactions were obtained at angles 0{degrees} to 160{degrees} for 3.675 MeV {le} E{sub {alpha}} {le} 6.325 MeV. A zero-degree excitation function for alpha particles between 3.5 MeV and 8.5 MeV in 75 keV steps was also produced. A preliminary analysis of the ground state transition shows only a narrow peak of approximately 200 keV FWHM and a broad peak of approximately 1.0 MeV FWHM at E{sub {alpha}} = 4.0 MeV and E{sub {alpha}} = 5.6 MeV, respectively. Details and results of this investigation as well as preliminary R-Matrix calculations will be discussed.

  17. Measurement of $\\alpha$-particle quenching in LAB based scintillator in independent small-scale experiments

    CERN Document Server

    von Krosigk, B; Hans, S; Junghans, A R; Kögler, T; Kraus, C; Kuckert, L; Liu, X; Nolte, R; O'Keeffe, H M; Tseung, H S Wan Chan; Wilson, J R; Wright, A; Yeh, M; Zuber, K


    The $\\alpha$-particle light response of liquid scintillators based on linear alkylbenzene (LAB) has been measured with three different experimental approaches. In the first approach, $\\alpha$-particles were produced in the scintillator via $^{12}$C($n$,$\\alpha$)$^9$Be reactions. In the second approach, the scintillator was loaded with 2% of $^{\\mathrm{nat}}$Sm providing an $\\alpha$-emitter, $^{147}$Sm, as an internal source. In the third approach, a scintillator flask was deployed into the water-filled SNO+ detector and the radioactive contaminants $^{222}$Rn, $^{218}$Po and $^{214}$Po provided the $\\alpha$-particle signal. The behavior of the observed $\\alpha$-particle light outputs are in agreement with each case successfully described by Birks' law. The resulting Birks parameter $kB$ ranges from $(0.0071\\pm0.0003)$ cm/MeV to $(0.0076\\pm0.0003)$ cm/MeV. In the first approach, the $\\alpha$-particle light response was measured simultaneously with the light response of recoil protons produced via neutron-proto...

  18. RBI, a one-domain alpha-amylase/trypsin inhibitor with completely independent binding sites. (United States)

    Maskos, K; Huber-Wunderlich, M; Glockshuber, R


    The bifunctional inhibitor from Ragi (Eleusine coracana Gaertneri) (RBI) is the only member of the alpha-amylase/trypsin inhibitor family that inhibits both trypsin and alpha-amylase. Here, we show that both enzymes simultaneously and independently bind to RBI. The recently solved three-dimensional NMR structure of RBI has revealed that the inhibitor possesses a hitherto unknown fold for serine proteinase and alpha-amylase inhibitors. Despite its different fold, RBI obeys the standard mechanism observed for most protein inhibitors of serine proteinases and is a strong, competitive inhibitor of bovine trypsin (Ki = 1.2 +/- 0.2 nM). RBI is also a competitive inhibitor of porcine alpha-amylase (Ki = 11 +/- 2 nM) when a disaccharide is used as a substrate of alpha-amylase. However, the inhibition mode becomes complex when larger (> or = 7 saccharide units) alpha-amylase substrates are used. A second saccharide binding site on porcine alpha-amylase may enable larger oligosaccharides to displace RBI from its binding site in an intramolecular reaction.

  19. Trypanosoma cruzi: cruzipain and membrane-bound cysteine proteinase isoform(s) interacts with human alpha(2)-macroglobulin and pregnancy zone protein. (United States)

    Ramos, Adrián M; Duschak, Vilma G; Gerez de Burgos, Nelia M; Barboza, Mariana; Remedi, María S; Vides, Miguel A; Chiabrando, Gustavo A


    Plasmatic levels of pregnancy zone protein (PZP) increase in children with acute Chagas disease. PZP, as well as alpha2-macroglobulin (alpha2-M), are able to interact with Trypanosoma cruzi proteinases. The interaction of alpha2-M and PZP with cruzipain, the major cysteine proteinase of T. cruzi, was investigated. Several molecular changes on both alpha-M inhibitors under reaction with cruzipain were found. PAGE analysis showed: (i) formation of complexes of intermediate mobility and tetramerization of native alpha2-M and PZP, respectively; (ii) limited proteolysis of bait region in alpha2-M and PZP, and (iii) covalent binding of cruzipain to PZP and alpha2-M. Conformational and structural changes experimented by alpha-Ms correlate with modifications of the enzyme electrophoretic mobility and activity. Cruzipain-alpha-M complexes were also detected by gelatin SDS-PAGE and immunoblotting using polyclonal anti-cruzipain antibodies. Concomitantly, alpha2-M and PZP impaired the activity of cruzipain towards Bz-Pro-Phe-Arg-pNA substrate. In addition, alpha-Ms were able to form covalent complexes with membrane isoforms of cysteine proteinases cross-reacting with cruzipain. The present study suggests that both human alpha-macroglobulin inhibitors could prevent or minimize harmful action of cruzipain on host's molecules and hypothetically regulate parasite functions controlled by cruzipain.

  20. [Development of new methods in asymmetric reactions and their applications]. (United States)

    Node, Manabu


    Several novel methods using chiral reagents and biocatalysts for asymmetric reactions are described. Among those reactions, asymmetric reduction via a novel tandem Michael addition/Meerwein-Ponndorf-Verley reduction of acyclic alpha,beta-unsaturated ketones using a chiral mercapto alcohol, asymmetric synthesis of allene-1,3-dicarboxylate via crystallization induced asymmetric transformation, and improved asymmetric nitroolefination of lactones and lactames at alpha-carbon using new chiral reagents were developed. In the reactions using biocatalysts, asymmetric dealkoxycarbonylation of bicyclic beta-keto diesters having sigma-symmetry with lipase or esterase to give optically active beta-keto esters, the asymmetric reduction of bicyclic 1,3-diketones having sigma-symmetry with Baker's yeast to give optically active keto alcohols, and the asymmetric aldol reaction of glycine with threonine aldolase were also developed. The above mentioned products were effectively utilized as chiral building blocks for the asymmetric synthesis of natural products and drugs.

  1. Arabidopsis thaliana RGXT1 and RGXT2 encode Golgi-localized (1,3)-alpha-D-xylosyltransferases involved in the synthesis of pectic rhamnogalacturonan-II

    DEFF Research Database (Denmark)

    Madsen, Jack Egelund; Petersen, Bent Larsen; Motawia, Mohammed Saddik


    of a type II membrane protein structure. Soluble secreted forms of the corresponding proteins expressed in insect cells showed xylosyltransferase activity, transferring d-xylose from UDP-alpha-d-xylose to l-fucose. The disaccharide product was hydrolyzed by alpha-xylosidase, whereas no reaction...

  2. Phenylalanine Aminomutase-Catalyzed Addition of Ammonia to Substituted Cinnamic Acids : a Route to Enantiopure alpha- and beta-Amino Acids

    NARCIS (Netherlands)

    Szymanski, Wiktor; Wu, Bian; Weiner, Barbara; de Wildeman, Stefaan; Feringa, B.L.; B. Janssen, Dick


    An approach is described for the synthesis of aromatic alpha- and beta-amino acids that Uses phenylalanine aminomutase to catalyze a highly enantioselective addition of ammonia to substituted cinnamic acids. The reaction has a broad scope and yields Substituted alpha- and beta-phenylalanines with ex

  3. Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

    DEFF Research Database (Denmark)

    Olsen, Christian A; Jørgensen, Malene; Hansen, Steen H;


    [reaction: see text] A mild resin-immobilization strategy employing a readily prepared trityl bromide resin for anchoring building blocks via a phenol group has been developed. With N(alpha)-Fmoc-Tyr-OPfp as a starter building block, it was possible to prepare asymmetrically substituted hybrids o...... of spider- and wasp-type polyamine toxins using solid-phase peptide synthesis conditions....

  4. Syntheses and structure-activity relationships for some triazolyl p38 alpha MAPK inhibitors

    NARCIS (Netherlands)

    Seerden, Jean-Paul G.; Leusink-Ionescu, Gabriela; Leguijt, Robin; Saccavini, Catherine; Gelens, Edith; Dros, Bas; Woudenberg-Vrenken, Titia; Molema, Grietje; Kamps, Jan A. A. M.; Kellogg, Richard M.


    The design, synthesis and biological evaluation of novel triazolyl p38 alpha MAPK inhibitors with improved water solubility for formulation in cationic liposomes (SAINT-O-Somes) targeted at diseased endothelial cells is described. Water-solubilizing groups were introduced via a 'click' reaction of f

  5. SmI(2)-mediated carbon-carbon bond fragmentation in alpha-aminomethyl malonates. (United States)

    Xu, Qiongfeng; Cheng, Bin; Ye, Xinshan; Zhai, Hongbin


    A new and efficient samarium diiodide-promoted carbon-carbon bond fragmentation reaction of alpha-aminomethyl malonates, taking place normally at room temperature and generating the corresponding deaminomethylation products in 74-94% yields, is reported. The presence of the amino group is necessary for the success of the current transformation.

  6. Description of alpha-nucleus interaction cross sections for cosmic ray shielding studies (United States)

    Cucinotta, Francis A.; Townsend, Lawrence W.; Wilson, John W.


    Nuclear interactions of high-energy alpha particles with target nuclei important for cosmic ray studies are discussed. Models for elastic, quasi-elastic, and breakup reactions are presented and compared with experimental data. Energy-dependent interaction cross sections and secondary spectra are presented based on theoretical models and the limited experimental data base.

  7. Quantum chemical calculations on the Peterson olefination with alpha-silyl ester enolates

    DEFF Research Database (Denmark)

    Gillies, Malcolm Bjørn; Tønder, Janne E.; Tanner, David Ackland


    The reaction of stabilized Peterson reagents (alpha-silyl ester enolates) with ketones has been studied theoretically and experimentally. Enolate geometry was studied by trapping experiments and NMR spectroscopy and was found to differ markedly with the nature of the base (LiHMDS vs LDA vs KHMDS...

  8. Volatility Measurements Of Reaction Chamber-Generated Particles

    Energy Technology Data Exchange (ETDEWEB)

    Paulsen, D. [PSI and ETH Zuerich (Switzerland); Duplissy, J.; Weingartner, E.; Alfarra, R. [University of Manchester (United Kingdom); Baltensperger, U.


    A volatility-tandem differential mobility analyzer (VTDMA) was designed to monitor the non-volatile fraction of reaction chamber-generated organic particles. Using a coiled-tube heater for particle volatilization, particle volume fraction remaining measurements were made for wall temperatures of 100, 150, and 200 C. Oligomerization of organic particles generated from irradiations of {alpha}-pinene/NO{sub x} in the reaction chamber shows a strong linear relationship with time. (author)

  9. Scale setting for alpha_s beyond leading order

    CERN Document Server

    Hornbostel, K; Morningstar, C J


    We present a general procedure for incorporating higher-order information into the scale-setting prescription of Brodsky, Lepage and Mackenzie. In particular, we show how to apply this prescription when the leading coefficient or coefficients in a series in the strong coupling alpha_s are anomalously small and the original prescription can give an unphysical scale. We give a general method for computing an optimum scale numerically, within dimensional regularization, and in cases when the coefficients of a series are known. We apply it to the heavy quark mass and energy renormalization in lattice NRQCD, and to a variety of known series. Among the latter, we find significant corrections to the scales for the ratio of e+e- to hadrons over muons, the ratio of the quark pole to MSbar mass, the semi-leptonic B-meson decay width, and the top decay width. Scales for the latter two decay widths, expressed in terms of MSbar masses, increase by factors of five and thirteen, respectively, substantially reducing the size...

  10. Catalysis of Photochemical Reactions. (United States)

    Albini, A.


    Offers a classification system of catalytic effects in photochemical reactions, contrasting characteristic properties of photochemical and thermal reactions. Discusses catalysis and sensitization, examples of catalyzed reactions of excepted states, complexing ground state substrates, and catalysis of primary photoproducts. (JM)

  11. Targeted alpha therapy for cancer

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Barry J [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Raja, Chand [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Rizvi, Syed [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Li Yong [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Tsui, Wendy [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Zhang, David [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Song, Emma [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Qu, C F [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Kearsley, John [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Graham, Peter [Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah 2217, NSW (Australia); Thompson, John [Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown 2050 NSW (Australia)


    Targeted alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer cells. The practicality and efficacy of TAT is tested by in vitro and in vivo studies in melanoma, leukaemia, colorectal, breast and prostate cancers, and by a phase 1 trial of intralesional TAT for melanoma. The alpha-emitting radioisotope used is Bi-213, which is eluted from the Ac-225 generator and chelated to a cancer specific monoclonal antibody (mab) or protein (e.g. plasminogen activator inhibitor-2 PAI2) to form the alpha-conjugate (AC). Stable alpha-ACs have been produced which have been tested for specificity and cytotoxicity in vitro against melanoma (9.2.27 mab), leukaemia (WM60), colorectal (C30.6), breast (PAI2, herceptin), ovarian (PAI2, herceptin, C595), prostate (PAI2, J591) and pancreatic (PAI2, C595) cancers. Subcutaneous inoculation of 1-1.5 million human cancer cells into the flanks of nude mice causes tumours to grow in all mice. Tumour growth is compared for untreated controls, nonspecific AC and specific AC, for local (subcutaneous) and systemic (tail vein or intraperitoneal) injection models. The {sup 213}Bi-9.2.27 AC is injected into secondary skin melanomas in stage 4 patients in a dose escalation study to determine the effective tolerance dose, and to measure kinematics to obtain the equivalent dose to organs. In vitro studies show that TAT is one to two orders of magnitude more cytotoxic to targeted cells than non-specific ACs, specific beta emitting conjugates or free isotopes. In vivo local TAT at 2 days post-inoculation completely prevents tumour formation for all cancers tested so far. Intra-lesional TAT can completely regress advanced sc melanoma but is less successful for breast and prostate cancers. Systemic TAT inhibits the growth of sc melanoma xenografts and gives almost complete control of breast and prostate cancer tumour growth. Intralesional doses up to 450 {mu

  12. Linearized Bekenstein Varying Alpha Models

    CERN Document Server

    Pina-Avelino, P; Oliveira, J C


    We study the simplest class of Bekenstein-type, varying $\\alpha$ models, in which the two available free functions (potential and gauge kinetic function) are Taylor-expanded up to linear order. Any realistic model of this type reduces to a model in this class for a certain time interval around the present day. Nevertheless, we show that no such model is consistent with all existing observational results. We discuss possible implications of these findings, and in particular clarify the ambiguous statement (often found in the literature) that ``the Webb results are inconsistent with Oklo''.

  13. The Alpha Magnetic Spectrometer (AMS)

    Energy Technology Data Exchange (ETDEWEB)

    Alcaraz, J.; Alpat, B.; Ambrosi, G.; Anderhub, H.; Ao, L.; Arefiev, A.; Azzarello, P.; Babucci, E.; Baldini, L.; Basile, M.; Barancourt, D.; Barao, F.; Barbier, G.; Barreira, G.; Battiston, R.; Becker, R.; Becker, U.; Bellagamba, L.; Bene, P.; Berdugo, J.; Berges, P.; Bertucci, B.; Biland, A.; Bizzaglia, S.; Blasko, S.; Boella, G.; Boschini, M.; Bourquin, M.; Brocco, L.; Bruni, G.; Buenerd, M.; Burger, J.D.; Burger, W.J.; Cai, X.D.; Camps, C.; Cannarsa, P.; Capell, M.; Casadei, D.; Casaus, J.; Castellini, G.; Cecchi, C.; Chang, Y.H.; Chen, H.F.; Chen, H.S.; Chen, Z.G.; Chernoplekov, N.A.; Chiueh, T.H.; Chuang, Y.L.; Cindolo, F.; Commichau, V.; Contin, A. E-mail:; Crespo, P.; Cristinziani, M.; Cunha, J.P. da; Dai, T.S.; Deus, J.D.; Dinu, N.; Djambazov, L.; DAntone, I.; Dong, Z.R.; Emonet, P.; Engelberg, J.; Eppling, F.J.; Eronen, T.; Esposito, G.; Extermann, P.; Favier, J.; Fiandrini, E.; Fisher, P.H.; Fluegge, G.; Fouque, N.; Galaktionov, Yu.; Gervasi, M.; Giusti, P.; Grandi, D.; Grimm, O.; Gu, W.Q.; Hangarter, K.; Hasan, A.; Hermel, V.; Hofer, H.; Huang, M.A.; Hungerford, W.; Ionica, M.; Ionica, R.; Jongmanns, M.; Karlamaa, K.; Karpinski, W.; Kenney, G.; Kenny, J.; Kim, W.; Klimentov, A.; Kossakowski, R.; Koutsenko, V.; Kraeber, M.; Laborie, G.; Laitinen, T.; Lamanna, G.; Laurenti, G.; Lebedev, A.; Lee, S.C.; Levi, G.; Levtchenko, P.; Liu, C.L.; Liu, H.T.; Lopes, I.; Lu, G.; Lu, Y.S.; Luebelsmeyer, K.; Luckey, D.; Lustermann, W.; Mana, C.; Margotti, A.; Mayet, F.; McNeil, R.R.; Meillon, B.; Menichelli, M.; Mihul, A.; Mourao, A.; Mujunen, A.; Palmonari, F.; Papi, A.; Park, I.H.; Pauluzzi, M.; Pauss, F.; Perrin, E.; Pesci, A.; Pevsner, A.; Pimenta, M.; Plyaskin, V.; Pojidaev, V.; Postolache, V.; Produit, N.; Rancoita, P.G.; Rapin, D.; Raupach, F.; Ren, D.; Ren, Z.; Ribordy, M.; Richeux, J.P.; Riihonen, E.; Ritakari, J.; Roeser, U.; Roissin, C.; Sagdeev, R.; Sartorelli, G.; Schultz von Dratzig, A.; Schwering, G.; Scolieri, G.; Seo, E.S.; Shoutko, V.


    The Alpha Magnetic Spectrometer (AMS) is a large acceptance (0.65 sr m{sup 2}) detector designed to operate in the International Space Station (ISS) for three years. The purposes of the experiment are to search for cosmic antimatter and dark matter and to study the composition and energy spectrum of the primary cosmic rays. A 'scaled-down' version has been flown on the Space Shuttle Discovery for 10 days in June 1998. The complete AMS is programmed for installation on the ISS in October 2003 for an operational period of 3 yr. This contribution reports on the experimental configuration that will be installed on the ISS.

  14. The Alpha Magnetic Spectrometer (AMS)

    CERN Document Server

    Alcaraz, J; Ambrosi, G; Anderhub, H; Ao, L; Arefev, A; Azzarello, P; Babucci, E; Baldini, L; Basile, M; Barancourt, D; Barão, F; Barbier, G; Barreira, G; Battiston, R; Becker, R; Becker, U; Bellagamba, L; Bene, P; Berdugo, J; Berges, P; Bertucci, B; Biland, A; Bizzaglia, S; Blasko, S; Bölla, G; Boschini, M; Bourquin, Maurice; Brocco, L; Bruni, G; Buénerd, M; Burger, J D; Burger, W J; Cai, X D; Camps, C; Cannarsa, P; Capell, M; Casadei, D; Casaus, J; Castellini, G; Cecchi, C; Chang, Y H; Chen, H F; Chen, H S; Chen, Z G; Chernoplekov, N A; Tzi Hong Chiueh; Chuang, Y L; Cindolo, F; Commichau, V; Contin, A; Crespo, P; Cristinziani, M; Cunha, J P D; Dai, T S; Deus, J D; Dinu, N; Djambazov, L; Dantone, I; Dong, Z R; Emonet, P; Engelberg, J; Eppling, F J; Eronen, T; Esposito, G; Extermann, P; Favier, Jean; Fiandrini, E; Fisher, P H; Flügge, G; Fouque, N; Galaktionov, Yu; Gervasi, M; Giusti, P; Grandi, D; Grimm, O; Gu, W Q; Hangarter, K; Hasan, A; Hermel, V; Hofer, H; Huang, M A; Hungerford, W; Ionica, M; Ionica, R; Jongmanns, M; Karlamaa, K; Karpinski, W; Kenney, G; Kenny, J; Kim, W; Klimentov, A; Kossakowski, R; Koutsenko, V F; Kraeber, M; Laborie, G; Laitinen, T; Lamanna, G; Laurenti, G; Lebedev, A; Lee, S C; Levi, G; Levchenko, P M; Liu, C L; Liu, H T; Lopes, I; Lu, G; Lü, Y S; Lübelsmeyer, K; Luckey, D; Lustermann, W; Maña, C; Margotti, A; Mayet, F; McNeil, R R; Meillon, B; Menichelli, M; Mihul, A; Mourao, A; Mujunen, A; Palmonari, F; Papi, A; Park, I H; Pauluzzi, M; Pauss, Felicitas; Perrin, E; Pesci, A; Pevsner, A; Pimenta, M; Plyaskin, V; Pozhidaev, V; Postolache, V; Produit, N; Rancoita, P G; Rapin, D; Raupach, F; Ren, D; Ren, Z; Ribordy, M; Richeux, J P; Riihonen, E; Ritakari, J; Röser, U; Roissin, C; Sagdeev, R; Sartorelli, G; Schwering, G; Scolieri, G; Seo, E S; Shoutko, V; Shoumilov, E; Siedling, R; Son, D; Song, T; Steuer, M; Sun, G S; Suter, H; Tang, X W; Ting, Samuel C C; Ting, S M; Tornikoski, M; Torsti, J; Ulbricht, J; Urpo, S; Usoskin, I; Valtonen, E; Vandenhirtz, J; Velcea, F; Velikhov, E P; Verlaat, B; Vetlitskii, I; Vezzu, F; Vialle, J P; Viertel, Gert M; Vitè, Davide F; Gunten, H V; Wallraff, W; Wang, B C; Wang, J Z; Wang, Y H; Wiik, K; Williams, C; Wu, S X; Xia, P C; Yan, J L; Yan, L G; Yang, C G; Yang, M; Ye, S W; Yeh, P; Xu, Z Z; Zhang, H Y; Zhang, Z P; Zhao, D X; Zhu, G Y; Zhu, W Z; Zhuang, H L; Zichichi, A; Zimmermann, B


    The Alpha Magnetic Spectrometer (AMS) is a large acceptance (0.65 sr m sup 2) detector designed to operate in the International Space Station (ISS) for three years. The purposes of the experiment are to search for cosmic antimatter and dark matter and to study the composition and energy spectrum of the primary cosmic rays. A 'scaled-down' version has been flown on the Space Shuttle Discovery for 10 days in June 1998. The complete AMS is programmed for installation on the ISS in October 2003 for an operational period of 3 yr. This contribution reports on the experimental configuration that will be installed on the ISS.

  15. Orthopositronium lifetime at O({alpha}) and O({alpha}{sup 3} ln {alpha}) in closed form

    Energy Technology Data Exchange (ETDEWEB)

    Kniehl, B.A.; Kotikov, A.V.; Veretin, O.L. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik


    Recently, the O({alpha}) and O({alpha}{sup 3} ln{alpha}) radiative corrections to the orthopositronium lifetime have been presented in closed analytical form, in terms of basic irrational numbers that can be evaluated numerically to arbitrary precision [Phys. Rev. Lett. 101, 193401 (2008)]. Here, we present the details of this calculation and reveal the nature of these new constants. We also list explicit transformation formulas for generalized polylogarithms of weight four, which may be useful for other applications. (orig.)

  16. Excitation function calculations for α + 93Nb nuclear reactions (United States)

    Yiğit, M.; Tel, E.; Sarpün, İ. H.


    In this study, the excitation functions of alpha-induced reactions on the 93Nb target nucleus were calculated by using ALICE-ASH code. The hybrid model, Weisskopf-Ewing model and geometry dependent hybrid model in this code were used to understand the alpha-niobium interaction. The contribution on the nuclear interaction of compound and pre-compound processes, with variation of the incident alpha particle energy, was presented. Furthermore, the reaction cross sections were calculated by using different level density models such as Superfluid nuclear model, Fermi gas model and Kataria-Ramamurthy Fermi gas model. Obtaining a good agreement between the calculated and the measured cross sections, the exciton numbers and the nuclear level density models were varied. Finally, the proper choice of the exciton numbers and the nuclear level density models was found to be quite important in order to obtain the more realistic cross section values.

  17. [Allergic reactions to transfusion]. (United States)

    Hergon, E; Paitre, M L; Coeffic, B; Piard, N; Bidet, J M


    Frequent allergic reactions following transfusion are observed. Usually, they are benign but sometimes we observe severe allergic reactions. Adverse reactions may be brought about by least two mechanisms. First, immediate-type hypersensibility reactions due to IgE. Secondly, anaphylactic-type reactions due to interaction between transfused IgA and class specific anti IgA in the recipient's plasma. They are characterized by their severest form (anaphylactic shock). The frequency of severe reactions following the transfusion blood plasma is very low. These transfusion reactions are complement-mediated and kinins-mediated. Prevention of allergic reactions is necessary among blood donors and recipients.

  18. Three-Dimensional Conformal Radiotherapy in Prostate Cancer Patients: Rise in Interleukin 6 (IL-6) but not IL-2, IL-4, IL-5, Tumor Necrosis Factor-{alpha}, MIP-1-{alpha}, and LIF Levels

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira Lopes, Carlos [Universidade do Vale do Paraiba, Centro de Oncologia Radioterapica do Vale do Paraiba, Universidade do Vale do Paraiba Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraiba, Sao Jose dos Campos, Sao Paulo (Brazil); Callera, Fernando, E-mail: [Centro de Hematologia Onco-hematologia e Transplantes de Medula Ossea do Vale do Paraiba, Sao Paulo (Brazil)


    Purpose: To investigate the effect of radiotherapy (RT) on serum levels of interleukin-2 (IL-2), IL-4, IL-5, IL-6, tumor necrosis factor alpha (TNF-{alpha}), macrophage inflammatory protein-1-alpha (MIP-1-{alpha}) and leukemia inhibitory factor (LIF) in patients with prostate cancer. Methods and Materials: Forty eight patients with prostate cancer received three-dimensional conformal blocking radiation therapy with a linear accelerator. IL-2, IL-4, IL-5, IL-6, TNF-{alpha}, MIP-1-{alpha}, and LIF levels were measured by the related immunoassay kit 1 day before the beginning of RT and during RT at days 15 and 30. Results: The mean IL-2 values were elevated before and during the RT in contrast with those of IL-4, IL-5, IL-6, TNF-{alpha}, MIP-1-{alpha}, and LIF, which were within the normal range under the same conditions. Regarding markers IL-2, IL-4, IL-5, TNF-{alpha}, MIP-1-{alpha}, and LIF, comparisons among the three groups (before treatment and 15 and 30 days during RT) did not show significant differences. Although values were within the normal range, there was a significant rise in IL-6 levels at day 15 of RT (p = 0.0049) and a decline at day 30 to levels that were similar to those observed before RT. Conclusions: IL-6 appeared to peak after 15 days of RT before returning to pre-RT levels. In contrast, IL-2, IL-4, IL-5, TNF-{alpha}, MIP-1-{alpha}, and LIF levels were not sensitive to irradiation. The increased levels of IL-6 following RT without the concurrent elevation of other cytokines involved in the acute phase reaction did not suggest a classical inflammatory response to radiation exposure. Further studies should be designed to elucidate the role of IL-6 levels in patients with prostate cancer treated with RT.

  19. Selective sorting of alpha-granule proteins. (United States)

    Italiano, J E; Battinelli, E M


    One of the main functions of blood platelets is to secrete a variety of substances that can modify a developing thrombus, regulate the growth of the vasculature, promote wound repair, and contribute to cell-adhesive events. A majority of this vast array of secreted proteins are stored in alpha-granules. Until recently, it was assumed that platelets contained one homogeneous population of alpha-granules that undergo complete de-granulation during platelet activation. This review focuses on the mechanisms of alpha-granule biogenesis and secretion, with a particular emphasis on recent findings that clearly demonstrate that platelets contain distinct subpopulations of alpha-granules that undergo differential release during activation. We consider the implications of this new paradigm of platelet secretion, discuss mechanisms of alpha-granule biogenesis, and review the molecular basis of transport and delivery of alpha-granules to assembling platelets.

  20. The Role of Alpha Activity in Spatial and Feature-Based Attention (United States)

    Miller, Lee M.


    Abstract Modulations in alpha oscillations (∼10 Hz) are typically studied in the context of anticipating upcoming stimuli. Alpha power decreases in sensory regions processing upcoming targets compared to regions processing distracting input, thereby likely facilitating processing of relevant information while suppressing irrelevant. In this electroencephalography study using healthy human volunteers, we examined whether modulations in alpha power also occur after the onset of a bilaterally presented target and distractor. Spatial attention was manipulated through spatial cues and feature-based attention through adjusting the color-similarity of distractors to the target. Consistent with previous studies, we found that informative spatial cues induced a relative decrease of pretarget alpha power at occipital electrodes contralateral to the expected target location. Interestingly, this pattern reemerged relatively late (300–750 ms) after stimulus onset, suggesting that lateralized alpha reflects not only preparatory attention, but also ongoing attentive stimulus processing. Uninformative cues (i.e., conveying no information about the spatial location of the target) resulted in an interaction between spatial attention and feature-based attention in post-target alpha lateralization. When the target was paired with a low-similarity distractor, post-target alpha was lateralized (500–900 ms). Crucially, the lateralization was absent when target selection was ambiguous because the distractor was highly similar to the target. Instead, during this condition, midfrontal theta was increased, indicative of reactive conflict resolution. Behaviorally, the degree of alpha lateralization was negatively correlated with the reaction time distraction cost induced by target–distractor similarity. These results suggest a pivotal role for poststimulus alpha lateralization in protecting sensory processing of target information. PMID:27822505

  1. Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites. (United States)

    Serra-Pérez, Anna; Planas, Anna M; Núñez-O'Mara, Analía; Berra, Edurne; García-Villoria, Judit; Ribes, Antònia; Santalucía, Tomàs


    Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that activates the cellular response to hypoxia. The HIF1alpha subunit is constantly synthesized and degraded under normoxia, but degradation is rapidly inhibited when oxygen levels drop. Oxygen-dependent hydroxylation by prolyl-4-hydroxylases (PHD) mediates HIF1alpha proteasome degradation. Brain ischemia limits the availability not only of oxygen but also of glucose. We hypothesized that this circumstance could have a modulating effect on HIF. We assessed the separate involvement of oxygen and glucose in HIF1alpha regulation in differentiated neuroblastoma cells subjected to ischemia. We report higher transcriptional activity and HIF1alpha expression under oxygen deprivation in the presence of glucose (OD), than in its absence (oxygen and glucose deprivation, OGD). Unexpectedly, HIF1alpha was not degraded at reoxygenation after an episode of OGD. This was not due to impairment of proteasome function, but was associated with lower HIF1alpha hydroxylation. Krebs cycle metabolites fumarate and succinate are known inhibitors of PHD, while alpha-ketoglutarate is a co-substrate of the reaction. Lack of HIF1alpha degradation in the presence of oxygen was accompanied by a very low alpha-ketoglutarate/fumarate ratio. Furthermore, treatment with a fumarate analogue prevented HIF1alpha degradation under normoxia. In all, our data suggest that postischemic metabolic alterations in Krebs cycle metabolites impair HIF1alpha degradation in the presence of oxygen by decreasing its hydroxylation, and highlight the involvement of metabolic pathways in HIF1alpha regulation besides the well known effects of oxygen.

  2. Scope and mechanism of carbohydrase action. Stereocomplementary hydrolytic and glucosyl-transferring actions of glucoamylase and glucodextranase with alpha- and beta-D-glucosyl fluoride. (United States)

    Kitahata, S; Brewer, C F; Genghof, D S; Sawai, T; Hehre, E J


    Rhizopus niveus glucoamylase and Arthrobacter globiformis glucodextranase, which catalyze the hydrolysis of starch and dextrans, respectively, to form D-glucose of inverted (beta) configuration, were found to convert both alpha- and beta-D-glucosyl fluoride to beta-D-glucose and hydrogen fluoride. Each enzyme directly hydrolyzes alpha-D-glucosyl fluoride but utilizes th beta-anomer in reactions that require 2 molecules of substrate and yield glucosyl transfer products which are then rapidly hydrolyzed to form beta-D-glucose. Various D-glucopyranosyl compounds serve as acceptors for such reactions. Mixtures of beta-D-glucosyl fluoride and methyl-alpha-D-glucopyranoside[14C], incubated with either enzyme, yielded both methyl-alpha-D-glucopyranosyl-(1 leads to 4)-alpha-D-[14C]glucopyranoside and methyl-alpha-D-glucopyranosyl-(1 leads to 6)-alpha-D-[14C]glucopyranoside. Glucoamylase produced more of the alpha-maltoside; glucodextranase produced more of the alpha-isomaltoside. Thus, both "exo-alpha-glucan hydrolases" emerge as glucosylases that catalyze stereospecifically complementary hydrolytic and transglucosylative reactions with glucosyl donors of opposite configuration. These reactions not only provide a new view of the catalytic capabilities of these supposedly strict hydrolases; they also furnish a basis for defining a detailed mechanism for catalysis. Present results, together with those of several recent studies from this laboratory (especially similar findings obtained with beta-amylase acting on alpha- and beta-maltosyl fluoride (Hehre, E. J., Brewer, C. F., and Genghof, D. S. (1979) J. Biol. Chem. 254, 5942-5950), provide strong new evidence for the functional flexibility of the catalytic groups of carbohydrases.

  3. The alpha,alpha-(1-->1) linkage of trehalose is key to anhydrobiotic preservation. (United States)

    Albertorio, Fernando; Chapa, Vanessa A; Chen, Xin; Diaz, Arnaldo J; Cremer, Paul S


    This study compares the efficacy of six disaccharides and glucose for the preservation of solid supported lipid bilayers (SLBs) upon exposure to air. Disaccharide molecules containing an alpha,alpha-(1-->1) linkage, such as alpha,alpha-trehalose and alpha,alpha-galacto-trehalose, were found to be effective at retaining bilayer structure in the absence of water. These sugars are known to crystallize in a clam shell conformation. Other saccharides, which are found to crystallize in more open structures, did not preserve the SLB structure during the drying process. These included the nonreducing sugar, sucrose, as well as maltose, lactose, and the monosaccharide, glucose. In fact, even close analogs to alpha,alpha-trehalose, such as alpha,beta-trehalose, which connects its glucopyranose rings via a (1-->1) linkage in an axial, equatorial fashion, permitted nearly complete delamination and destruction of supported bilayers upon exposure to air. Lipids with covalently attached sugar molecules such as ganglioside GM1, lactosyl phosphatidylethanolamine, and glucosylcerebroside were also ineffective at preserving bilayer structure. The liquid crystalline-to-gel phase transition temperature of supported phospholipid bilayers was tested in the presence of sugars in a final set of experiments. Only alpha,alpha-trehalose and alpha,alpha-galacto-trehalose depressed the phase transition temperature, whereas the introduction of other sugar molecules into the bulk solution caused the phase transition temperature of the bilayer to increase. These results point to the importance of the axial-axial linkage of disaccharides for preserving SLB structure.

  4. The human interleukin-1 alpha gene is located on the long arm of chromosome 2 at band q13. (United States)

    Lafage, M; Maroc, N; Dubreuil, P; de Waal Malefijt, R; Pébusque, M J; Carcassonne, Y; Mannoni, P


    Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. Recently, it has been shown that IL-1 alpha is identical to hematopoietin 1, which was described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors. In this report we discuss our use of in situ hybridization on human prometaphase cells with a human IL-1 alpha cDNA probe to localize the human IL-1 alpha gene on the proximal part of the long arm of chromosome 2 at band q13, in the same chromosomal region as the IL-1 beta gene.

  5. 3-(4-Methyl-3-pentenyl)-2(5H)-furanone, alpha,alpha-acariolide and 4-(4-methyl-3-pentenyl)-2(5H)-furanone, alpha,beta-acariolide: new monoterpene lactones from the astigmatid mites, Schwiebea araujoae and Rhizoglyphus sp. (Astigmata: Acaridae). (United States)

    Tarui, Hirokazu; Mori, Naoki; Nishida, Ritsuo; Okabe, Kimiko; Kuwahara, Yasumasa


    A new monoterpene lactone from the acarid mite, Schwiebea araujoae, was elucidated without its isolation by GC/FT-IR and GC/MS analyses to be 3-(4-methyl-3-pentenyl)-2(5H)-furanone (1) and tentatively named as alpha,alpha-acariolide. The structure of 1 was identified by its synthesis from alpha-bromo-gamma-butyrolactone via 4 reaction steps. The synthesized compound gave the same GC/MS and GC/FT-IR spectra as those of the natural product. The other monoterpene lactone was likewise elucidated from the unidentified Rhizoglyphus mite to be 4-(4-methyl-3-pentenyl)-2(5H)-furanone (2) and named as alpha,beta-acariolide; it was also identified by its synthesis in 5 reaction steps from the same butyrolactone as the starting material. GC/MS and GC/FT-IR spectra of the preparation were identical to those of the natural product.

  6. Tumor Necrosis Factor (TNF-alpha) Treatment of Ankylosing Spondylitis Clinical Adverse Reactions Observed%肿瘤坏死因子拮抗剂(TNF-α)治疗强直性脊柱炎临床不良反应观察

    Institute of Scientific and Technical Information of China (English)



      Objective:To learn about the common and the rare adverse reactions taking place in the clinical treatment of ankylosing spondylitis with tumor necrosis factor (TNF) antagonist.Method:50 cases of patients were enrolled in this group receiving TNF antagonist (the product used in this group was Etanercept from Shanghai CP Guojian Pharmaceutical Co,Ltd) for treating ankylosing spondylitis.In addition,the incidence of adverse reactions and the common reverse reactions were observed.Result:Of the 50 patients received TNF antagonist for treating ankylosing spondylitis,first-dosage adverse reactions occurred in eight cases and medium or long-term adverse reactions occurred in 5 cases.Conclusion:The usage of biological agent in the treatment of ankylosing spondylitis is considered as a safe and efficacious approach,in which the occurrence and management of the adverse reactions should be concerned.%  目的:了解接受肿瘤坏死因子拮抗剂治疗强直性脊柱炎临床常见不良反应及少见不良反应。方法:本组选取了50例强直性脊柱炎患者接受肿瘤坏死因子拮抗剂(本组均选用上海中信科健公司产品益赛普)治疗,同时观察不良反应发生率及常见不良反应症状。结果:接受肿瘤坏死因子拮抗剂治疗的50例患者发生首次不良反应的有8例,中长期不良反应5例。结论:生物制剂治疗强直性脊柱炎是安全有效的,但应注意不良反应的发生及处置。

  7. alpha-particle production in the scattering of 6He by 208Pb at energies around the Coulomb barrier


    Escrig, D.; Sanchez-Benitez, A M; Moro, A. M.; Alvarez, M. A. G.; Andres, M. V.; Angulo, C.; Borge, M. J. G.; J. Cabrera; Cherubini, S.; Demaret, P; Espino, J. M.; Figuera, P.; Freer, M.; Garcia-Ramos, J. E.; Gomez-Camacho, J.


    New experimental data from the scattering of 6He+208Pb at energies around and below the Coulomb barrier are presented. The yield of breakup products coming from projectile fragmentation is dominated by a strong group of $\\alpha$ particles. The energy and angular distributions of this group have been analyzed and compared with theoretical calculations. This analysis indicates that the $\\alpha$ particles emitted at backward angles in this reaction are mainly due to two-neutron transfer to weakl...

  8. Role of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in acute lung injury in rats

    DEFF Research Database (Denmark)

    Shanley, T P; Schmal, H; Friedl, H P


    The role of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in the pathogenesis of acute lung injury in rats after intrapulmonary deposition of IgG immune complexes or intratracheal administration of LPS has been assessed. Critical to these studies was the cloning and functional expression...... of rat MIP-1 alpha. The resulting product shared 92% and 90% homology with the known murine sequence at the cDNA level and protein level, respectively. Recombinant rat MIP-1 alpha exhibited dose-dependent chemotactic activity for both rat and human monocytes and neutrophils, which could be blocked...... by anti-murine MIP-1 alpha Ab. Rat MIP-1 alpha mRNA and protein expression were determined as a function of time in both injury models. A time-dependent increase in MIP-1 alpha mRNA in lung extracts was observed in both models. In the LPS model, MIP-1 alpha protein could also be detected...

  9. $\\alpha_{s}$ from the (revised) ALEPH data for $\\tau$ decay

    CERN Document Server

    Boito, Diogo; Maltman, Kim; Osborne, James; Peris, Santiago


    We present a new analysis of $\\alpha_s$ from hadronic $\\tau$ decays based on the recently revised ALEPH data. The analysis is based on a strategy which we previously applied to the OPAL data. We critically compare our strategy to the one traditionally used and comment on the main differences. Our analysis yields the values $\\alpha_s(m_\\tau^2)=0.296\\pm 0.010$ using fixed-order perturbation theory, and $\\alpha_s(m_\\tau^2)=0.310\\pm 0.014$ using contour-improved perturbation theory. Averaging these values with our previously obtained values from the OPAL data, we find $\\alpha_s(m_\\tau^2)=0.303\\pm 0.009$, respectively, $\\alpha_s(m_\\tau^2)=0.319\\pm 0.012$, as the most reliable results for $\\alpha_s$ from $\\tau$ decays currently available.

  10. SOURCES 4C : a code for calculating ([alpha],n), spontaneous fission, and delayed neutron sources and spectra.

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, W. B. (William B.); Perry, R. T. (Robert T.); Shores, E. F. (Erik F.); Charlton, W. S. (William S.); Parish, Theodore A.; Estes, G. P. (Guy P.); Brown, T. H. (Thomas H.); Arthur, Edward D. (Edward Dana),; Bozoian, Michael; England, T. R.; Madland, D. G.; Stewart, J. E. (James E.)


    SOURCES 4C is a computer code that determines neutron production rates and spectra from ({alpha},n) reactions, spontaneous fission, and delayed neutron emission due to radionuclide decay. The code is capable of calculating ({alpha},n) source rates and spectra in four types of problems: homogeneous media (i.e., an intimate mixture of a-emitting source material and low-Z target material), two-region interface problems (i.e., a slab of {alpha}-emitting source material in contact with a slab of low-Z target material), three-region interface problems (i.e., a thin slab of low-Z target material sandwiched between {alpha}-emitting source material and low-Z target material), and ({alpha},n) reactions induced by a monoenergetic beam of {alpha}-particles incident on a slab of target material. Spontaneous fission spectra are calculated with evaluated half-life, spontaneous fission branching, and Watt spectrum parameters for 44 actinides. The ({alpha},n) spectra are calculated using an assumed isotropic angular distribution in the center-of-mass system with a library of 107 nuclide decay {alpha}-particle spectra, 24 sets of measured and/or evaluated ({alpha},n) cross sections and product nuclide level branching fractions, and functional {alpha}-particle stopping cross sections for Z < 106. The delayed neutron spectra are taken from an evaluated library of 105 precursors. The code provides the magnitude and spectra, if desired, of the resultant neutron source in addition to an analysis of the'contributions by each nuclide in the problem. LASTCALL, a graphical user interface, is included in the code package.

  11. Introduction of all-hydrocarbon i,i+3 staples into alpha-helices via ring-closing olefin metathesis. (United States)

    Kim, Young-Woo; Kutchukian, Peter S; Verdine, Gregory L


    The introduction of all-hydrocarbon i,i+3 staples into alpha-helical peptide scaffolds via ring-closing olefin metathesis (RCM) between two alpha-methyl,alpha-pentenylglycine residues incorporated at i and i+3 positions, which lie on the same face of the helix, has been investigated. The reactions were found to be highly dependent upon the side-chain stereochemistry of the amino acids undergoing RCM. The i,i+3 stapling system established here provides a potentially useful alternative to the well-established i,i+4 stapling system now in widespread use.

  12. Hydrogen embrittlement on {alpha}-iron in high alkaline environment

    Energy Technology Data Exchange (ETDEWEB)

    Hu, R.; Habashi, M.; Galland, J. [Ecole Central Paris, Chatenay-Malabry (France)


    The partial pressure of hydrogen in concrete`s pore is very low. This hydrogen is due to the chemical reaction between the silica fumes and the alkaline solutions filling the concrete`s pore. Silica fumes are added in the concrete to increase its compression resistance. If the hydrogen pressure is low, the risk of hydrogen embrittlement is also low. However, for constructional works destined to endure more than 50 years, is this risk negligible? To answer this question, the authors have studied the hydrogen embrittlement on {alpha}-iron in alkaline solutions, in the pH range 9.5 to 13.3, presenting the liquids found in the concrete`s pores after different aging, periods. Cathodic charging has been performed for low current densities in the range 0.25 to 90 A/m{sup 2} simulating several partial pressures of hydrogen on the {alpha}-iron surface with and without EDTA inhibitor. The deformation rate was 2.5{times}10{sup {minus}5} s{sup {minus}1}. Finally {alpha}-iron samples and tensile specimens have been immersed in a mixture of silica fumes and an alkaline solution at pH 13.3 in an autoclave during 1,000 hours with the aim to measure the outgassed quantity of hydrogen under vacuum at 600C and to measure also the hydrogen embrittlement. The main conclusions of this study are as following: (1) Hydrogen embrittlement is promoted by oxide Fe{sub 3}O{sub 4} film rupture and/or hydroxide Fe(OH){sub 2}. This mechanism is efficient for current densities equivalent to a cathodic potential lower or equal to {minus}1V/NHE. (2) Silica fumes in contact with a solution of pH 13.3 provoke hydrogen release and its diffusion into the {alpha}-iron, but this quantity is not enough to embrittle it.

  13. EEG, alpha waves and coherence (United States)

    Ascolani, Gianluca

    This thesis addresses some theoretical issues generated by the results of recent analysis of EEG time series proving the brain dynamics are driven by abrupt changes making them depart from the ordinary Poisson condition. These changes are renewal, unpredictable and non-ergodic. We refer to them as crucial events. How is it possible that this form of randomness be compatible with the generation of waves, for instance alpha waves, whose observation seems to suggest the opposite view the brain is characterized by surprisingly extended coherence? To shed light into this apparently irretrievable contradiction we propose a model based on a generalized form of Langevin equation under the influence of a periodic stimulus. We assume that there exist two different forms of time, a subjective form compatible with Poisson statistical physical and an objective form that is accessible to experimental observation. The transition from the former to the latter form is determined by the brain dynamics interpreted as emerging from the cooperative interaction among many units that, in the absence of cooperation would generate Poisson fluctuations. We call natural time the brain internal time and we make the assumption that in the natural time representation the time evolution of the EEG variable y(t) is determined by a Langevin equation perturbed by a periodic process that in this time representation is hardly distinguishable from an erratic process. We show that the representation of this random process in the experimental time scale is characterized by a surprisingly extended coherence. We show that this model generates a sequence of damped oscillations with a time behavior that is remarkably similar to that derived from the analysis of real EEG's. The main result of this research work is that the existence of crucial events is not incompatible with the alpha wave coherence. In addition to this important result, we find another result that may help our group, or any other research

  14. {alpha}-Pinene conversion by modified-kaolinitic clay

    Energy Technology Data Exchange (ETDEWEB)

    Volzone, C. [CETMIC-Centro de Tecnologia de Recursos Minerales y Ceramica-(CONICET-CIC), C.C. 49, Cno. Centenario y 506 (1897) M.B. Gonnet, Prov., Buenos Aires (Argentina)]. E-mail:; Masini, O. [INTEQUI (CONICET-UNSL), Facultad de Ingenieria y Ciencias Economico Sociales, 25 de Mayo 384, V. Mercedes, Prov., San Luis (Argentina); Comelli, N.A. [INTEQUI (CONICET-UNSL), Facultad de Ingenieria y Ciencias Economico Sociales, 25 de Mayo 384, V. Mercedes, Prov., San Luis (Argentina); Grzona, L.M. [INTEQUI (CONICET-UNSL), Facultad de Ingenieria y Ciencias Economico Sociales, 25 de Mayo 384, V. Mercedes, Prov., San Luis (Argentina); Ponzi, E.N. [CINDECA (CONICET-UNLP) calle 47 No. 257 (1900) La Plata, Prov., Buenos Aires (Argentina); Ponzi, M.I. [INTEQUI (CONICET-UNSL), Facultad de Ingenieria y Ciencias Economico Sociales, 25 de Mayo 384, V. Mercedes, Prov., San Luis (Argentina)


    The isomerization of {alpha}-pinene using natural kaolinitic clay before and after different treatments was studied in this work. The kaolinite is a clay material constituted by phyllosilicate 1:1 layer (one sheet of tetrahedral silicon and one sheet of octahedral alumina). The clay was treated at different times using 6.0 N solution of sulfuric acid previous heating to 500 or 700 K. The materials were characterized by X-ray diffraction, by chemical analyses and acidity measurements. The catalytic reactions were carried out at 373 K in a reactor batch with condenser and stirrer. Samples were taken at regular intervals, and reactants and products were quantitatively analyzed with a gas chromatograph after separation of the individual compounds. Conversions of alpha pinene between 67 and 94%, and selectivities in camphene and in limonene of 65 and 23%, respectively, were obtained with the clay treated at different conditions. The structural and textural changes of the clay by the treatments influenced on catalytic reactions.

  15. Evaluation of Alpha-case in Titanium Castings

    Institute of Scientific and Technical Information of China (English)


    The alpha-case formation reactions between Ti and investment molds (Al2O3, ZrSiO4, ZrO2, CaO stabilized ZrO2) were evaluated in a plasma arc melting furnace. Regardless of thermodynamic approaches, there were distinct alpha-case formations. The reaction products were characterized by electron probe micro-analysis and transmission electron microscopy. The α-case generation between Ti and Al2O3 mold was not able to be explained by the conventional α-case formation mechanism, which is known to be formed by the interstitials, especially oxygen dissolved from mold materials. However, from our experimental results and thermodynamic calculations, it was confirmed that the c-case is formed not only by an interstitial element but also by substitutional metallic elements dissolved from mold materials. Our newly established α-case formation mechanism will surely lead to a variety of significant applications of the α-case controlled Ti casting.

  16. Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated. (United States)

    Blithe, D L


    The carbohydrate compositions of pregnancy-derived hCG alpha (dissociated from intact hCG) and free alpha-subunit were analyzed using a combination of chemical analysis, lectin affinity chromatography, and glycosidase sensitivity. For direct compositional analysis, parallel samples were hydrolyzed in trifluoroacetic acid and analyzed for sialic acid and neutral sugars without prior derivatization. Separation of the monosaccharides was achieved by HPLC on a Dionex CarboPac column eluted at high pH, and the resolved monosaccharides were quantified by pulsed amperometric detection. The amounts of sugar that were found relative to peptide indicated the presence of two N-linked oligosaccharides per molecule on both hCG alpha and free alpha. Free alpha contained 2.5-fold higher amounts of sialic acid and galactose as well as a higher amount of N-acetylglucosamine than did hCG alpha. Free alpha also contained a 6-fold higher amount of fucose than did hCG alpha (1.2 vs. 0.2 residues of fucose/molecule). Serial fractionation of intact hCG alpha and free alpha molecules by lectin affinity chromatography indicated that virtually all of the hCG alpha-subunits contained at least one Concanavalin-A (Con-A)-binding site, whereas as many as 32% of the free alpha molecules could not bind to Con-A. Chromatography on Lens culinaris (Lch) resulted in 12% binding of hCG alpha and approximately 72% binding of free alpha (80-85% of the Con-A-bound free alpha and 47-48% of the Con-A-nonbound free alpha bound to Lch). Endoglycosidase-H (endo-H) treatment of hCG alpha released a portion of the oligosaccharides. The endo-H-released material appeared to be a monoantennary hybrid based on DEAE-binding properties and carbohydrate composition. In contrast to hCG alpha, free alpha was completely resistant to endo-H treatment. Incubation of endo-H-resistant hCG alpha with glycopeptidase-A resulted in the release of two components, which could be separated into monoantennary and biantennary

  17. A revised thermonuclear rate of $^{7}$Be($n$,$\\alpha$)$^{4}$He relevant to Big-Bang nucleosynthesis

    CERN Document Server

    Hou, S Q; Kubono, S; Chen, Y S


    In the standard Big-Bang nucleosynthesis (BBN) model, the primordial $^7$Li abundance is overestimated by about a factor of 2--3 comparing to the astronomical observations, so called the pending cosmological lithium problem. The $^7$Be($n$,$\\alpha$)$^4$He reaction, which may affect the $^7$Li abundance, was regarded as the secondary important reaction in destructing the $^7$Be nucleus in BBN. However, the thermonuclear rate of $^7$Be($n$,$\\alpha$)$^4$He has not been well studied so far. This reaction rate was firstly estimated by Wagoner in 1969, which has been generally adopted in the current BBN simulations and the reaction rate library. This simple estimation involved only a direct-capture reaction mechanism, but the resonant contribution should be also considered according to the later experimental results. In this work, we have revised this rate based on the indirect cross-section data available for the $^4$He($\\alpha$,$n$)$^7$Be and $^4$He($\\alpha$,$p$)$^7$Li reactions, with the charge symmetry and deta...


    NARCIS (Netherlands)



    The enzymatic hydrolyses of a variety of alpha-substituted mandelic and lactic esters using pig liver esterase (PLE) have been investigated. High to moderate enantioselectivity was found for various alpha-substituted mandelic esters, whereas PLE showed low to no enantioselectivity for alpha-substitu

  19. Matching coefficients for alpha_s and m_b to O(alpha_s^2) in the MSSM

    CERN Document Server

    Bauer, A; Salomon, J


    We compute the exact two-loop matching coefficients for the strong coupling constant alpha_s and the bottom-quark mass m_b within the Minimal Supersymmetric Standard Model (MSSM), taking into account O(alpha_s^2) contributions from Supersymmetric Quantum Chromodynamics (SQCD). We find that the explicit mass pattern of the supersymmetric particles has a significant impact on the predictions of alpha_s and m_b at high energies. Further on, the three-loop corrections exceed the uncertainty due to the current experimental accuracy. In case of the the running bottom-quark mass, they can reach in the large tan(beta) regime up to 30% from the tree-level value.

  20. Inhibitory activity of the white wine compounds, tyrosol and caffeic acid, on lipopolysaccharide-induced tumor necrosis factor-alpha release in human peripheral blood mononuclear cells. (United States)

    Giovannini, L; Migliori, M; Filippi, C; Origlia, N; Panichi, V; Falchi, M; Bertelli, A A E; Bertelli, A


    The objective of this study was to assess whether tyrosol and caffeic acid are able to inhibit lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha release. TNF is one of the most important cytokines involved in inflammatory reactions. The results show that both tyrosol and caffeic acid are able to inhibit LPS-induced TNF-alpha release from human monocytes, even at low doses. Their mechanisms of action are discussed and we conclude that high doses of the two compounds are not required to achieve effective inhibition of inflammatory reactions due to TNF-alpha release.

  1. Local Varying-Alpha Theories

    CERN Document Server

    Barrow, John D


    In a recent paper we demonstrated how the simplest model for varying alpha may be interpreted as the effect of a dielectric material, generalized to be consistent with Lorentz invariance. Unlike normal dielectrics, such a medium cannot change the speed of light, and its dynamics obey a Klein-Gordon equation. This work immediately suggests an extension of the standard theory, even if we require compliance with Lorentz invariance. Instead of a wave equation, the dynamics may satisfy a local algebraic relation involving the permittivity and the properties of the electromagnetic field, in analogy with more conventional dielectric (but still preserving Lorentz invariance). We develop the formalism for such theories and investigate some phenomenological implications. The problem of the divergence of the classical self-energy can be solved, or at least softened, in this framework. Some interesting new cosmological solutions for the very early universe are found, including the possibility of a bounce, inflation and e...

  2. Alpha Shape Topology of the Cosmic Web

    NARCIS (Netherlands)

    Weygaert, Rien van de; Platen, Erwin; Vegter, Gert; Eldering, Bob; Kruithof, Nico


    We study the topology of the Megaparsec Cosmic Web on the basis of the Alpha Shapes of the galaxy distribution. The simplicial complexes of the alpha shapes are used to determine the set of Betti numbers (βk, k = 1, . . . , D), which represent a complete characterization of the topology of a manifol

  3. The ALPHA detector : Module Production and Assembly

    CERN Document Server

    Andresen, G; Bowe, P D; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Fujiwara, M C; Gill, D R; Hangst, J S; Hydomako, R; Jenkins, M J; Kurchaninov, L; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Povilus, A; Robicheaux, F; Sarid, E; Silveira, D M; Storey, J W; Thompson, R I; van der Werf, D P; Wurtele, J S; Yamazaki, Y; Ashkezari, M D; Baquero-Ruiz, M; Butler, E; Deller, A; Eriksson, S; Friesen, T; Gutierrez, A; Hardy, W N; Hayden, M E; Humphries, A J; Jonsell, S; McKenna, J T K; Menary, S; Pusa, P; Sampson, J; Seddon, D; Seif el Nasr, S; So, C; Thornhill, J; Wells, D; Jorgensen, L V


    ALPHA is one of the experiments situated at CERN's Antiproton Decelerator (AD). A Silicon Vertex Detector (SVD) is placed to surround the ALPHA atom trap. The main purpose of the SVD is to detect and locate antiproton annihilation events by means of the emitted charged pions. The SVD system is presented with special focus given to the design, fabrication and performance of the modules.

  4. Bayesian Meta-Analysis of Coefficient Alpha (United States)

    Brannick, Michael T.; Zhang, Nanhua


    The current paper describes and illustrates a Bayesian approach to the meta-analysis of coefficient alpha. Alpha is the most commonly used estimate of the reliability or consistency (freedom from measurement error) for educational and psychological measures. The conventional approach to meta-analysis uses inverse variance weights to combine…

  5. Remote Associates Test and Alpha Brain Waves (United States)

    Haarmann, Henk J.; George, Timothy; Smaliy, Alexei; Dien, Joseph


    Previous studies found that performance on the remote associates test (RAT) improves after a period of incubation and that increased alpha brain waves over the right posterior brain predict the emergence of RAT insight solutions. We report an experiment that tested whether increased alpha brain waves during incubation improve RAT performance.…

  6. ALPHA experiment facility and Prof. Jeffrey Hangst.

    CERN Multimedia

    Maximilien Brice


    Picture 01-07: General views of the ALPHA experiment Picture 5: Andrea Gutierrez, a PhD student from UBC, transfers liquid helium from a storage dewar into the cryostat containing the superconducting magnetic trap used by the ALPHA experiment.Picture 08-11: Jeffery Hangst, spokesperson for ALPHA Picture 12: The ALPHA silicon detector, which surrounds the trapping resion and is used for imaging antiproton annihilations (Credit University of Liverpool) Picture 13: Untrapped antihydrogen atoms annihilating on the inner surface of the ALPHA trap. These are measured by the ALPHA annihilation detector. The events are concentrated at the electrode radius of about 22.3 mm. The coordinates are defined in the Nature article, Figure 1b. Picture 14: The electrodes (gold) for the ALPHA Penning trap being inserted into the vacuum chamber and cryostat assembly. This is the trap used to combine or "mix" positrons and antiprotons to make antihydrogen. (Credit: Niels Madsen ALPHA/Swansea.) Picture 15: Top, a diagram of the...

  7. Measurement of the angle alpha at BABAR

    CERN Document Server

    Pérez, A


    We present recent measurements of the CKM angle alpha using data collected by the BABAR detector at the PEP-II asymmetric-energy e^+e^- collider at the SLAC National Accelerator Laboratory, operating at the Upsilon(4S) resonance. We present constraints on alpha from B->pipi, B->rhorho and B->rhopi decays.

  8. Atypical Alpha Asymmetry in Adults with ADHD (United States)

    Hale, T. Sigi; Smalley, Susan L.; Hanada, Grant; Macion, James; McCracken, James T.; McGough, James J.; Loo, Sandra K.


    Introduction: A growing body of literature suggests atypical cerebral asymmetry and interhemispheric interaction in ADHD. A common means of assessing lateralized brain function in clinical populations has been to examine the relative proportion of EEG alpha activity (8-12 Hz) in each hemisphere (i.e., alpha asymmetry). Increased rightward alpha…

  9. Psychiatric Symptoms in Alpha-Mannosidosis (United States)

    Malm, D.; Pantel, J.; Linaker, O. M.


    Alpha-mannosidosis is characterized by mild to moderate intellectual disability (ID), moderate to severe neurosensory hearing loss, frequent infections, psychomotor disturbances and skeletal dysmorphism. For the first time, a panel of nine alpha-mannosidosis patients with psychiatric symptoms is presented. The clinical picture has several…

  10. Confidence Intervals for Cronbach's Coefficient Alpha Values

    NARCIS (Netherlands)

    A.J. Koning (Alex); Ph.H.B.F. Franses (Philip Hans)


    textabstractCoefficient Alpha, which is widely used in empirical research, estimates the reliability of a test consisting of parallel items. In practice it is difficult to compare values of alpha across studies as it depends on the number of items used. In this paper we provide a simple solution, wh

  11. Teaching Calculus with Wolfram|Alpha (United States)

    Dimiceli, Vincent E.; Lang, Andrew S. I. D.; Locke, LeighAnne


    This article describes the benefits and drawbacks of using Wolfram|Alpha as the platform for teaching calculus concepts in the lab setting. It is a result of our experiences designing and creating an entirely new set of labs using Wolfram|Alpha. We present the reasoning behind our transition from using a standard computer algebra system (CAS) to…

  12. Anomalous atomic volume of alpha-Pu

    DEFF Research Database (Denmark)

    Kollar, J.; Vitos, Levente; Skriver, Hans Lomholt


    .3%. The comparison between the LDA and GGA results show that the anomalously large atomic volume of alpha-Pu relative to alpha-Np can be ascribed to exchange-correlation effects connected with the presence of low coordinated sites in the structure where the f electrons are close to the onset of localization...

  13. Food allergy to the carbohydrate galactose-alpha-1,3-galactose (alpha-gal): four case reports and a review. (United States)

    Bircher, Andreas J; Hofmeier, Kathrin Scherer; Link, Susanne; Heijnen, Ingmar


    Until recently, food allergies to mammalian meats have been considered to be very rare. The observation that patients not previously exposed to the monoclonal chimeric antibody cetuximab suffered from severe anaphylaxis upon first exposure, led to the identification of galactose-alpha-1,3-galactose as a new relevant carbohydrate allergen. These patients later often suffered from anaphylactic reactions to red meat. Epidemiological data indicated that bites by the tick Amblyomma americanum in the USA, later also by Ixodes species in other continents, resulted in sensitisation to alpha-gal. On the other hand, in African patients with parasitic disorders, a high prevalence of anti-alpha-gal IgE, without clinical relevance, has been reported. In our four cases, one patient with a late onset of meat allergy had a history of a tick bite. The other three patients had symptoms from childhood or at a juvenile age. This indicates that in some patients, other ways of sensitisation may also take place. However, in patients without atopy, tick bite-induced IgE to alpha-gal may be more relevant. Diagnosis is based on a history of delayed onset of anaphylaxis. Skin tests with commercially available meat test solutions are often equivocal or negative; skin tests with raw meat and particularly pork kidney are more sensitive. Determination of specific IgE to alpha-gal is commercially available. The highest sensitivity is observed with skin and basophil activation tests with cetuximab which is, however, limited by its high costs.

  14. Cloning and comparative analysis of gene structure in promoter site of alpha-s1 casein gene in Naeinian goat and sheep

    Directory of Open Access Journals (Sweden)

    Mojtaba Najafi


    Full Text Available The 5′ end or alpha-S1 casein promoter has a significant role in milk protein gene expression. The understanding of the translation process of alpha-S1 casein mutants will provide us an opportunity to make the best selection in livestock providing more proteins in milk. Blood samples were taken from three hundred of Naeinian goats and sheep, and DNA extraction was done using modified salting out method. Polymerase chain reactions (PCR were carried out using a specific primer pairs for amplification a fragment of 1133 bp from part of 5′-UTR and exon 1 of alpha s1 casein gene. The AluI and HinfI restriction enzyme treatment of all samples provided the same homozygous AA genotype in both species. Subsequently, one sample of each species was selected and cloned, and the final sequences were analyzed by BioEdit, CLC genomic, Mega4 and DNASIS MAX software. Several polymorphisms are recognized between Naeinian goat and sheep that are presented on motif sites. In this research, the interested location, including exon I and a part of 5′, was analyzed, and genetic element comparisons were done between Naeinian goat and sheep. The number and location of probable binding sites can have a crucial role as a result of antagonistic and synergistic effects on gene regulation activities.

  15. Evaluation of (alpha,n) Induced Neutrons as a Background for Dark Matter Experiments

    CERN Document Server

    Mei, D -M; Hime, A


    Neutrons from ($\\alpha$,n) reaction through thorium and uranium decays are important sources of background for direct dark matter detection. Neutron yield and energy spectrum from a range of materials that are used to build dark matter detectors are calculated and tabulated. In addition to thorium and uranium decays, we found that $\\alpha$ particles from samarium that is often doped in the window material of photomultiplier (PMT) are also an important source of neutron yield. The results in this paper can be used as the input in the Monte Carlo simulation for many materials that will be used for next generation experiments.

  16. Methods of depositing an alpha-silicon-carbide-containing film at low temperature

    Energy Technology Data Exchange (ETDEWEB)

    Habermehl, Scott D.


    Described methods are useful for depositing a silicon carbide film including Alpha-SiC at low temperatures (e.g., below about C.), and resulting multi-layer structures and devices. A method includes introducing a chlorinated hydrocarbon gas and a chlorosilicon gas into a reaction chamber, and reacting the chlorinated hydrocarbon gas with the chlorosilicon gas at a temperature of less than about C. to grow the silicon carbide film. The silicon carbide film so-formed includes Alpha-SiC.

  17. Purification and characterization of the commercialized, cloned Bacillus megaterium. alpha. -amylase. Pt. 2. Transferase properties

    Energy Technology Data Exchange (ETDEWEB)

    Brumm, P.J.; Hebeda, R.E.; Teague, W.M.


    Using an assay procedure based on reduction of iodine binding to starch, Bacillus megaterium, {alpha}-amylase (BMA) demonstrated transferase activity using a wide range of acceptors. The enzyme had an absolute requirement for glucose or glucosides for acceptor molecules. Maltose acted as a transferase acceptor at low concentrations and as an inhibitor of starch hydrolysis at high concentrations. Kinetic analysis indicated that, in the presence of a suitable acceptor, the mechanism of starch hydrolysis is Ping Pong Bi Bi. The products of the transferase reaction have been determined using p-nitro-{alpha}-D-glucopyranoside as acceptor combined with a novel HPLC-based system for product detection. (orig.).

  18. Target characterization for the 130Ba(alpha,gamma)134Ce gamma-process experiment

    CERN Document Server

    Gyürky, Gy; Farkas, J; Fülöp, Zs; Somorjai, E; Szücs, T


    In order to extend the available experimental database for the astrophysical gamma-process, the cross section measurement of the 130Ba(alpha,gamma)134Ce and 130Ba(alpha,n)133Ce reactions is in progress. The measurements are carried out using thin layers of evaporated BaCO3 as target. Since the target thickness enters directly into the calculation of the cross sections, the reliability of its determination is of crucial importance. Three different methods have been used to determine the target thickness. Details of these experiments and the obtained results are presented.

  19. Setup for Fission and Evaporation Cross-Section Measurements in Reactions Induced by Secondary Beams

    CERN Document Server

    Hassan, A A; Kalpakchieva, R; Skobelev, N K; Penionzhkevich, Yu E; Dlouhý, Z; Radnev, S; Poroshin, N V


    A setup for studying reactions induced by secondary radioactive beams has been constructed. It allows simultaneous measurement of alpha-particle and fission fragment energy spectra. By measuring the alpha-particles, identification of evaporation residues is achieved. A set of three targets can be used so as to ensure sufficient statistics. Two silicon detectors, located at 90 degrees to the secondary beam direction, face each target, thus covering 30 % of the solid angle. This experimental setup is to be used to obtain excitation functions of fusion?fission reactions and of reactions leading to evaporation residue production.

  20. Production of sup 5 sup 5 Co via the sup 5 sup 4 Fe(d, n)-process and excitation functions of sup 5 sup 4 Fe(d, t) sup 5 sup 3 Fe and sup 5 sup 4 Fe(d, alpha) sup 5 sup 2 sup m Mn reactions from threshold up to 13.8 MeV

    CERN Document Server

    Zaman, M R; Qaim, S M


    For production of the medically interesting beta; sup + -emitter sup 5 sup 5 Co (T sup 1 sup / sup 2 = 17.6 h) via the sup 5 sup 4 Fe(d, n)-reaction, 91.6% enriched sup 5 sup 4 Fe sub 2 O sub 3 , mixed with Al powder, was pressed to a pellet which could be irradiated with 14 MeV deuterons at 4 mu A in a water-cooled target system. A separation method was developed which led to > 99.9% pure sup 5 sup 5 Co and allowed a recovery of the enriched target material. For a target thickness of E sub d = 12.6 -> 5 MeV, the experimental thick target yield of sup 5 sup 5 Co after chemical separation amounted to about 13 MBq/mu A.h, which is about 60% of the theoretical value. In a 3 h irradiation at 4 mu A, the batch yield of sup 5 sup 5 Co achieved was 160 MBq (4.3 mCi). An 8 h irradiation could lead to a batch yield of about 400 MBq. The sup 5 sup 4 Fe(d, n) reaction leads to the highest purity sup 5 sup 5 Co but it is essential that the isotopic enrichment of the target is not less than 90%. In addition to the product...

  1. A potent effect of strong $\\bar{\\mbox{p}}-$p nuclear forces on the rate of the low-energy three-body protonium formation reaction: $\\bar{\\mbox{p}} + (\\mbox{p}\\mu^-)_{1s} \\rightarrow (\\bar{\\mbox{p}} \\mbox{p})_{\\alpha} + \\mu^-$

    CERN Document Server

    Sultanov, Renat A; Adhikari, Sadhan K


    The effect of the strong $\\bar{\\rm p}-$p nuclear interaction in a three-charge-particle system with arbitrary masses is investigated. Specifically, the ($\\bar{\\rm p},\\ \\mu^-$,\\ p) system is considered. A numerical computation in the framework of a detailed few-body approach is carried out for the following protonium (antiprotonic hydrogen) production three-body reaction: $\\bar{\\mbox{p}} +(\\mbox{p}\\mu^-)_{1s} \\rightarrow (\\bar{\\mbox{p}}\\rm{p})_{1s} + \\mu^-$. Here, p is a proton, $\\bar{\\mbox{p}}$ is an antiproton, $\\mu^-$ is a muon, and a bound state of $\\mbox{p}^+$ and its counterpart $\\bar{\\mbox{p}}$ is protonium: $Pn = (\\bar{\\mbox{p}}\\mbox{p})$. The low-energy cross sections and rates of the $Pn$ formation reaction are computed in the framework of a Faddeev-like equation formalism. The strong $\\bar{\\mbox{p}}-$p interaction is included in these calculations within a first order approximation. It was found, that the inclusion of this strong interaction results in a quite significant correction to the output of...

  2. Folate receptor {alpha} regulates cell proliferation in mouse gonadotroph {alpha}T3-1 cells

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Congjun; Evans, Chheng-Orn [Department of Neurosurgery and Laboratory of Molecular Neurosurgery and Biotechnology, Emory University, School of Medicine, Atlanta, Georgia (United States); Stevens, Victoria L. [Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia (United States); Owens, Timothy R. [Emory University, School of Medicine, Atlanta, Georgia (United States); Oyesiku, Nelson M., E-mail: [Department of Neurosurgery and Laboratory of Molecular Neurosurgery and Biotechnology, Emory University, School of Medicine, Atlanta, Georgia (United States)


    We have previously found that the mRNA and protein levels of the folate receptor alpha (FR{alpha}) are uniquely over-expressed in clinically human nonfunctional (NF) pituitary adenomas, but the mechanistic role of FR{alpha} has not fully been determined. We investigated the effect of FR{alpha} over-expression in the mouse gonadotroph {alpha}T3-1 cell line as a model for NF pituitary adenomas. We found that the expression and function of FR{alpha} were strongly up-regulated, by Western blotting and folic acid binding assay. Furthermore, we found a higher cell growth rate, an enhanced percentage of cells in S-phase by BrdU assay, and a higher PCNA staining. These observations indicate that over-expression of FR{alpha} promotes cell proliferation. These effects were abrogated in the same {alpha}T3-1 cells when transfected with a mutant FR{alpha} cDNA that confers a dominant-negative phenotype by inhibiting folic acid binding. Finally, by real-time quantitative PCR, we found that mRNA expression of NOTCH3 was up-regulated in FR{alpha} over-expressing cells. In summary, our data suggests that FR{alpha} regulates pituitary tumor cell proliferation and mechanistically may involve the NOTCH pathway. Potentially, this finding could be exploited to develop new, innovative molecular targeted treatment for human NF pituitary adenomas.

  3. Alpha1 and Alpha2 Integrins Mediate Invasive Activity of Mouse Mammary Carcinoma Cells through Regulation of Stromelysin-1 Expression

    Energy Technology Data Exchange (ETDEWEB)

    Lochter, Andre; Navre, Marc; Werb, Zena; Bissell, Mina J


    Tumor cell invasion relies on cell migration and extracellular matrix proteolysis. We investigated the contribution of different integrins to the invasive activity of mouse mammary carcinoma cells. Antibodies against integrin subunits {alpha}6 and {beta}1, but not against {alpha}1 and {alpha}2, inhibited cell locomotion on a reconstituted basement membrane in two-dimensional cell migration assays, whereas antibodies against {beta}1, but not against a6 or {alpha}2, interfered with cell adhesion to basement membrane constituents. Blocking antibodies against {alpha}1 integrins impaired only cell adhesion to type IV collagen. Antibodies against {alpha}1, {alpha}2, {alpha}6, and {beta}1, but not {alpha}5, integrin subunits reduced invasion of a reconstituted basement membrane. Integrins {alpha}1 and {alpha}2, which contributed only marginally to motility and adhesion, regulated proteinase production. Antibodies against {alpha}1 and {alpha}2, but not {alpha}6 and {beta}1, integrin subunits inhibited both transcription and protein expression of the matrix metalloproteinase stromelysin-1. Inhibition of tumor cell invasion by antibodies against {alpha}1 and {alpha}2 was reversed by addition of recombinant stromelysin-1. In contrast, stromelysin-1 could not rescue invasion inhibited by anti-{alpha}6 antibodies. Our data indicate that {alpha}1 and {alpha}2 integrins confer invasive behavior by regulating stromelysin-1 expression, whereas {alpha}6 integrins regulate cell motility. These results provide new insights into the specific functions of integrins during tumor cell invasion.

  4. Alpha macroglobulins and the low-density-lipoprotein-related protein alpha-2-macroglobulin receptor in experimental renal fibrosis

    NARCIS (Netherlands)

    van Goor, H; Diamond, [No Value; Ding, GH; Kaysen, GA


    In this study, we evaluated the location of non-specific proteinase inhibitors and their receptor in experimental glomerular and interstitial fibrosis. The alpha macroglobulins alpha-2-macroglobulin (alpha 2M) and alpha-1-inhibitor 3 (alpha 1I3) are proteinase inhibitors, including metalloproteinase

  5. Exposure-sensitization relationship for alpha-amylase allergens in the baking industry. (United States)

    Houba, R; Heederik, D J; Doekes, G; van Run, P E


    Fungal alpha-amylase is an important occupational allergen in the bakery industry. Epidemiologic studies focusing on the relationship between alpha-amylase allergen exposure and work-related respiratory allergy, however, have not been reported yet. In this cross-sectional study, sensitization to occupational allergens and work-related symptoms were studied in 178 bakery workers and related to allergen exposure. Alpha-amylase allergen concentrations were measured in personal dust samples, using a sandwich enzyme immunoassay. All workers were categorized into groups on the basis of their job histories and the alpha-amylase exposure levels of their job titles. Of all workers 25% had one or more work-related symptoms. As much as 9% of the bakery workers showed a positive skin prick test reaction to fungal amylase, and in 8% amylase-specific IgE was demonstrated. Alpha-amylase exposure and atopy appeared to be the most important determinants of skin sensitization, with prevalence ratios for atopy of 20.8 (95% CI, 2.74 to 158) and for medium and high alpha-amylase exposure groups of 8.6 (95% CI, 1.01 to 74) and 15.9 (95% CI, 1.95 to 129), respectively. Furthermore, a positive association was found between positive skin prick tests to alpha-amylase and work-related respiratory symptoms. In conclusion, this study has shown that there is a strong and positive relationship between alpha-amylase allergen exposure levels in bakeries and specific sensitization in bakery workers.

  6. Radiative corrections to the muonium hyperfine structure; 1, the $\\alpha^{2}$ (Z$\\alpha$) correction

    CERN Document Server

    Kinoshita, T


    This is the first of a series of papers on a systematic application of the NRQED bound state theory of Caswell and Lepage to higher-order radiative corrections to the hyperfine structure of the muonium ground state. This paper describes the calculation of the \\alpha^2 (Z\\alpha) radiative correction. Our result for the complete \\alpha^2 (Z\\alpha) correction is 0.424(4) kHz, which reduces the theoretical uncertainty significantly. The remaining uncertainty is dominated by that of the numerical evaluation of the nonlogarithmic part of the \\alpha (Z\\alpha )^2 term and logarithmic terms of order \\alpha^4. These terms will be treated in the subsequent papers.

  7. The fratricide of alpha-Omega dynamos by their alpha-squared siblings

    CERN Document Server

    Hubbard, Alexander; Brandenburg, Axel


    Context. Helically forced magneto-hydrodynamic shearing-sheet turbulence can support different large-scale dynamo modes, although the {\\alpha} - {\\Omega} mode is generally expected to dominate because it is the fastest growing. In an {\\alpha} - {\\Omega} dynamo, most of the field amplification is produced by the shear. As differential rotation is an ubiquitous source of shear in astrophysics, such dynamos are believed to be the source of most astrophysical large-scale magnetic fields. Aims. We study the stability of oscillatory migratory {\\alpha} - {\\Omega} type dynamos in turbulence simulations. Methods. We use shearing-sheet simulations of hydromagnetic turbulence that is helically forced at a wavenumber that is about three times larger than the lowest wavenumber in the domain so that both {\\alpha} - {\\Omega} and {\\alpha}2 dynamo action is possible. Results. After initial dominance and saturation, the {\\alpha} - {\\Omega} mode is found to be destroyed by an orthogonal {\\alpha}2 mode sustained by the helical t...

  8. Cintichem modified process - {sup 99}Mo precipitation step: application of statistical analysis tools over the reaction parameters

    Energy Technology Data Exchange (ETDEWEB)

    Teodoro, Rodrigo; Dias, Carla R.B.R.; Osso Junior, Joao A., E-mail: jaosso@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Fernandez Nunez, Eutimio Gustavo [Universidade de Sao Paulo (EP/USP), SP (Brazil). Escola Politecnica. Dept. de Engenharia Quimica


    Precipitation of {sup 99}Mo by {alpha}-benzoin oxime ({alpha}-Bz) is a standard precipitation method for molybdenum due the high selectivity of this agent. Nowadays, statistical analysis tools have been employed in analytical systems to prove its efficiency and feasibility. IPEN has a project aiming the production of {sup 99}Mo by the fission of {sup 235}U route. The processing uses as the first step the precipitation of {sup 99}Mo with {alpha}-Bz. This precipitation step involves many key reaction parameters. The aim of this work is based on the development of the already known acidic route to produce {sup 99}Mo as well as the optimization of the reactional parameters applying statistical tools. In order to simulate {sup 99}Mo precipitation, the study was conducted in acidic media using HNO{sub 3}, {alpha}Bz as precipitant agent and NaOH /1%H{sub 2}O{sub 2} as dissolver solution. Then, a Mo carrier, KMnO{sub 4} solutions and {sup 99}Mo tracer were added to the reaction flask. The reactional parameters ({alpha}-Bz/Mo ratio, Mo carrier, reaction time and temperature, and cooling reaction time before filtration) were evaluated under a fractional factorial design of resolution V. The best values of each reactional parameter were determined by a response surface statistical planning. The precipitation and recovery yields of {sup 99}Mo were measured using HPGe detector. Statistical analysis from experimental data suggested that the reactional parameters {alpha}-Bz/Mo ratio, reaction time and temperature have a significant impact on {sup 99}Mo precipitation. Optimization statistical planning showed that higher {alpha}Bz/Mo ratios, room temperature, and lower reaction time lead to higher {sup 99}Mo yields. (author)

  9. [Contents and its change during storage of alpha-solanine and alpha-chaconine in potatoes]. (United States)

    Shindo, Tetsuya; Ushiyama, Hirofumi; Kan, Kimiko; Yasuda, Kazuo; Saito, Kazuo


    Contents of alpha-solanine and alpha-chaconine in native species of potato (May Queen, Danshaku and Waseshiro), and in species (Jagakids Red '90 (Red) and Jagakids Purple '90 (Purple)) on the market, and their change during storage at room temparature were investigated. alpha-Solanine and alpha-chaconine were extracted from potatoes with methanol, cleaned up by using a Sep-Pak Plus C18 cartridge, and then subjected to HPLC. The recoveries of alpha-solanine and alpha-chaconine from potatoes were both more than 96%, and the quantitation limits were both 2 microg/g. alpha-Solanine and alpha-chaconine were detected in periderm in all samples at the levels of 260-320 microg/g in May Queen,190-240 microg/g in Danshaku, 43-63 microg/g in Waseshiro, 140-200 microg/g in Red and 84-130 microg/g in Purple, respectively. alpha-Solanine and alpha-chaconine were detected in the cortex in all samples of May Queen and Danshaku at the levels of 2.7-12 microg/g and 5.8-31 microg/g, respectively. Contents of alpha-solanine and alpha-chaconine in the cortex of May Queen and Danshaku were less than 10% of those in the periderm. When potatoes were stored for 90 days at room temparature in a dark place, no marked change in the contents of alpha-solanine and alpha-chaconine was observed in any of the potato samples.

  10. Involvement of central alpha1-adrenoceptors on renal responses to central moxonidine and alpha-methylnoradrenaline. (United States)

    de Andrade, Carina A F; de Andrade, Glaucia M F; De Paula, Patricia M; De Luca, Laurival A; Menani, José V


    Moxonidine (alpha2-adrenoceptor/imidazoline receptor agonist) injected into the lateral ventricle induces diuresis, natriuresis and renal vasodilation. Moxonidine-induced diuresis and natriuresis depend on central imidazoline receptors, while central alpha1-adrenoceptors are involved in renal vasodilation. However, the involvement of central alpha1-adrenoceptors on diuresis and natriuresis to central moxonidine was not investigated yet. In the present study, the effects of moxonidine, alpha-methylnoradrenaline (alpha2-adrenoceptor agonist) or phenylephrine (alpha1-adrenoceptor agonist) alone or combined with previous injections of prazosin (alpha1-adrenoceptor antagonist), yohimbine or RX 821002 (alpha2-adrenoceptor antagonists) intracerebroventricularly (i.c.v.) on urinary sodium, potassium and volume were investigated. Male Holtzman rats (n = 5-18/group) with stainless steel cannula implanted into the lateral ventricle and submitted to gastric water load (10% of body weight) were used. Injections of moxonidine (20 nmol) or alpha-methylnoradrenaline (80 nmol) i.c.v. induced natriuresis (196 +/- 25 and 171 +/- 30, respectively, vs. vehicle: 101 +/- 9 microEq/2 h) and diuresis (9.0 +/- 0.4 and 12.3 +/- 1.6, respectively, vs. vehicle: 5.2 +/- 0.5 ml/2 h). Pre-treatment with prazosin (320 nmol) i.c.v. abolished the natriuresis (23 +/- 4 and 76 +/- 11 microEq/2 h, respectively) and diuresis (5 +/- 1 and 7.6 +/- 0.8 ml/2 h, respectively) produced by i.c.v. moxonidine or alpha-methylnoradrenaline. RX 821002 (320 nmol) i.c.v. abolished the natriuretic effect of alpha-methylnoradrenaline, however, yohimbine (320 nmol) did not change renal responses to moxonidine. Phenylephrine (80 nmol) i.c.v. induced natriuresis and kaliuresis that were blocked by prazosin. Therefore, the present data suggest that moxonidine and alpha-methylnoradrenaline acting on central imidazoline receptors and alpha2-adrenoceptors, respectively, activate central alpha1-adrenergic mechanisms to

  11. Mapping High-Velocity H-alpha and Lyman-alpha Emission from Supernova 1987A (United States)

    France, Kevin; McCray, Richard; Fransson, Claes; Larsson, Josefin; Frank, Kari A.; Burrows, David N.; Challis, Peter; Kirshner, Robert P.; Chevalier, Roger A.; Garnavich, Peter; Heng, Kevin; Lawrence, Stephen S.; Lundqvist, Peter; Smith, Nathan; Sonneborn, George


    We present new Hubble Space Telescope images of high-velocity H-alpha and Lyman-alpha emission in the outer debris of SN 1987A. The H-alpha images are dominated by emission from hydrogen atoms crossing the reverse shock. For the first time we observe emission from the reverse shock surface well above and below the equatorial ring, suggesting a bipolar or conical structure perpendicular to the ring plane. Using the H-alpha imaging, we measure the mass flux of hydrogen atoms crossing the reverse shock front, in the velocity intervals (-7,500 < V(sub obs) < -2,800 km/s) and (1,000 < V(sub obs) < 7,500 km/s), ?M(sub H) = 1.2 × 10(exp -3) M/ y. We also present the first Lyman-alpha imaging of the whole remnant and new Chandra X-ray observations. Comparing the spatial distribution of the Lyman-alpha and X-ray emission, we observe that the majority of the high-velocity Lyman-alpha emission originates interior to the equatorial ring. The observed Lyman-alpha/H-alpha photon ratio, R(L-alpha/H-alpha) approx. = 17, is significantly higher than the theoretically predicted ratio of approx. = 5 for neutral atoms crossing the reverse shock front. We attribute this excess to Lyman-alpha emission produced by X-ray heating of the outer debris. The spatial orientation of the Lyman-alpha and X-ray emission suggests that X-ray heating of the outer debris is the dominant Lyman-alpha production mechanism in SN 1987A at this phase in its evolution.

  12. A new alpha chain hemoglobin variant: Hb Al-Hammadi Riyadh [alpha75(EF4)Asp-->Val (alpha2)]. (United States)

    Burnichon, Nelly; Lacan, Philippe; Becchi, Michel; Zanella-Cleon, Isabelle; Aubry, Martine; Mowafy, Mohammed; Couprie, Nicole; Francina, Alain


    A new hemoglobin (Hb) variant in the heterozygous state, Hb Al-Hammadi Riyadh [codon 75 (GAC-->GTC); alpha75(EF4)Asp-->Val (alpha2)] corresponding to an A-->T transversion on the second exon of the alpha2-globin gene, is described. The variant was characterized by DNA sequencing and mass spectrometry (MS). The variant was found during a routine Hb analysis for anemia in a 16-month-old boy who lived in Riyadh, Kingdom of Saudi Arabia.

  13. $Q_{\\alpha}$-Normal Families and entire functions

    CERN Document Server

    Gul, Shai


    For every countable ordinal number $\\alpha$ we construct an entire function $f=f_\\alpha$ such that the family $\\left\\{f(nz):n\\in\\mathbb{N}\\right\\}$ is exactly $Q_\\alpha$-normal in the unit disk.

  14. Double Pion Production Reactions

    CERN Document Server

    Oset, E; Cano, F; Hernández, E; Kamalov, S S; Nacher, J C; Tejedor, J A G


    We report on reactions producing two pions induced by real and virtual photons or nucleons. The role of different resonances in these reactions is emphasized. Novel results on coherent two pion photoproduction in nuclei are also reported.

  15. Microfluidic chemical reaction circuits (United States)

    Lee, Chung-cheng; Sui, Guodong; Elizarov, Arkadij; Kolb, Hartmuth C.; Huang, Jiang; Heath, James R.; Phelps, Michael E.; Quake, Stephen R.; Tseng, Hsian-rong; Wyatt, Paul; Daridon, Antoine


    New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

  16. Microscale Thermite Reactions. (United States)

    Arnaiz, Francisco J.; Aguado, Rafael; Arnaiz, Susana


    Describes the adaptation of thermite (aluminum with metal oxides) reactions from whole-class demonstrations to student-run micro-reactions. Lists detailed directions and possible variations of the experiment. (WRM)

  17. Reaction Sensitivity of r-Process Nucleosynthesis

    CERN Document Server

    Sasaqui, T; Mathews, G J; Otsuki, K; Nakamura, K; Sasaqui, Taka.


    We study the efficiency and sensitivity of r-process nucleosynthesis to a number of light nuclear reaction rates. We adopt empirical power-law relations to parameterize the reaction sensitivities. We utilize two different hydrodynamic models for the neutrino-driven winds in order to study the dependence of our result on supernova wind models. We also utilize an exponential model to approximate a wide variety of other plausible conditions for the r-process. We identify several specific nuclear reactions among light neutron-rich nuclei that play a critical role in determining the final r-process nucleosynthesis yields. As an illustration, we examine ``semi-waing'' points among the carbon isotopes. We show that not only neutron capture and $\\beta$-decay, but also $(\\alpha, \\mathrm{n})$ reactions are important in determining waiting points along the r-process path. Our numerical results from this sensitivity analysis serve foremost to clarify which light nuclear reactions are most influential in determining the f...

  18. Chemical transport reactions

    CERN Document Server

    Schäfer, Harald


    Chemical Transport Reactions focuses on the processes and reactions involved in the transport of solid or liquid substances to form vapor phase reaction products. The publication first offers information on experimental and theoretical principles and the transport of solid substances and its special applications. Discussions focus on calculation of the transport effect of heterogeneous equilibria for a gas motion between equilibrium spaces; transport effect and the thermodynamic quantities of the transport reaction; separation and purification of substances by means of material transport; and

  19. Lucid dreaming and alpha activity: a preliminary report. (United States)

    Ogilvie, R D; Hunt, H T; Tyson, P D; Lucescu, M L; Jeakins, D B


    10 good dream recallers spent 2 nights in the sleep lab during which they were awakened 4 times per night from REM sleep, twice during their highest alpha activity in REM, and twice during low REM alpha. 5 were given alpha feedback training prior to sleep onset. Arousals from high alpha REM sleep yielded significantly higher lucidity ratings. Alpha feedback had no effect upon lucidity or REM alpha levels. Similarities between lucid dreams and meditative phenomena are discussed.

  20. Lyman alpha emission in starburst galaxies (United States)

    Kunth, Daniel


    We propose to perform a deep study of Ly-alpha emission and destruction in 3 star-forming galaxies. These objects have been already observed with the GHRS and exhibit a variety of situations, with Ly-alpha showing P Cyg profiles, secondary emissions or even a deep damped absorption line with no emission. They also span a range of intrinsic properties: IZW18 is a gas-rich, metal deficient dust free dwarf galaxy, Haro 2 has a simple morphology while IRAS 08339+6517 is a luminous IRAS starburst galaxy with more dust and complex Ly- alpha profile. The use of STIS will allow for the first time to study the geometrical/kinematical configuration of the ionized and neutral gas across the galaxies nuclear regions and pin point the effects of porosity and the kinematical structure of the ISM, that may play the key roles {in addition to dust} in the detectability of the line. This study will have important impact for cosmology since Ly-alpha emitters are nowaday found at high-re dshift. We strongly emphasize that since Ly-alpha is primarely a diagnostic of the ISM, a full understanding of how the ISM and Ly-alpha are related is a necessary step before we can hope to correlate Ly-alpha to the cosmic star-formation rate. Our results will be interpreted against the model of superbubble evolution developed with G. Tenorio Tagle.

  1. Diagnostics for PLX-alpha (United States)

    Gilmore, Mark; Hsu, Scott


    The goal of the Plasma Liner eXperiment PLX-alpha at Los Alamos National Laboratory is to establish the viability of creating a spherically imploding plasma liner for MIF and HED applications, using a spherical array of supersonic plasma jets launched by innovative contoured-gap coaxial plasma guns. PLX- α experiments will focus in particular on establishing the ram pressure and uniformity scalings of partial and fully spherical plasma liners. In order to characterize these parameters experimentally, a suite of diagnostics is planned, including multi-camera fast imaging, a 16-channel visible interferometer (upgraded from 8 channels) with reconfigurable, fiber-coupled front end, and visible and VUV high-resolution and survey spectroscopy. Tomographic reconstruction and data fusion techniques will be used in conjunction with interferometry, imaging, and synthetic diagnostics from modeling to characterize liner uniformity in 3D. Diagnostic and data analysis design, implementation, and status will be presented. Supported by the Advanced Research Projects Agency - Energy - U.S. Department of Energy.

  2. Lyman Alpha Spicule Observatory (LASO) (United States)

    Chamberlin, P. C.; Allred, J. C.; Airapetian, V.; Gong, Q.; Mcintosh, S. W.; De Pontieu, B.; Fontenla, J. M.


    The Lyman Alpha Spicule Observatory (LASO) sounding rocket will observe small-scale eruptive events called "Rapid Blue-shifted Events" (RBEs) [Rouppe van der Voort et al., 2009], the on-disk equivalent of Type-II spicules, and extend observations that explore their role in the solar coronal heating problem [De Pontieu et al., 2011]. LASO utilizes a new and novel optical design to simultaneously observe two spatial dimensions at 4.2" spatial resolution (2.1" pixels) over a 2'x2' field of view with high spectral resolution of 66mÅ (33mÅ pixels) across a broad 20Å spectral window. This spectral window contains three strong chromospheric and transition region emissions and is centered on the strong Hydrogen Lyman-α emission at 1216Å. This instrument makes it possible to obtain new data crucial to the physical understanding of these phenomena and their role in the overall energy and momentum balance from the upper chromosphere to lower corona. LASO was submitted March 2011 in response to the ROSES SHP-LCAS call.

  3. Reaction systems with precipitation

    Directory of Open Access Journals (Sweden)

    Marek Rogalski


    Full Text Available This article proposes expanding Reaction Systems of Ehrenfeucht and Rozenberg by incorporating precipitation reactions into it. This improves the computing power of Reaction Systems by allowing us to implement a stack. This addition enables us to implement a Deterministic Pushdown Automaton.

  4. Measurements of $\\alpha_s$ in $pp$ Collisions at the LHC

    CERN Document Server

    Warburton, Andreas; The ATLAS collaboration


    The coupling of the strong force, $\\alpha_s$, is deemed to be a fundamental parameter of Nature, and, beyond the quark masses, constitutes the only free parameter in the QCD Lagrangian. Provided is an overview of CERN Large Hadron Collider (LHC) measurements of $\\alpha_s(M_Z)$ evaluated at the $Z$-boson mass and of the running of $\\alpha_s(Q)$ as a function of energy-momentum transfer $Q$. The measurements were performed by the ATLAS and CMS Collaborations using proton-proton ($pp$) collisions with centre-of-mass energies of 7 TeV and data samples with time-integrated luminosities of up to 5 fb$^{-1}$. Four different categories of observable were used in the described extractions of $\\alpha_s$: inclusive jet cross sections, 3-jet to 2-jet inclusive cross-section ratios, 3-jet mass cross sections, and top-quark pair production cross sections. These results, which include the first NNLO measurement of $\\alpha_s$ at a hadron collider and the first determinations of $\\alpha_s$ at energy scales above 1 TeV, are co...

  5. Generalized dual symmetry of nonabelian theories and the freezing of \\alpha_s

    CERN Document Server

    Das, C R; Nielsen, H B


    The quantum Yang-Mills theory, describing a system of fields with non-dual (chromo-electric g) and dual (chromo-magnetic \\tilde g) charges and revealing the generalized dual symmetry, is developed by analogy with the Zwanziger formalism in QED. The renormalization group equations (RGEs) for pure nonabelian theories are analysed for both constants, \\alpha = g^2 / 4\\pi and \\tilde\\alpha = {\\tilde g}^2 / 4\\pi. The pure SU(3) \\times \\widetilde{SU(3)} gauge theory is investigated as an example. We consider not only monopoles, but also dyons. The behaviour of the total SU(3) \\beta-function is investigated in the whole region of \\alpha \\equiv \\alpha_s: 0 \\le \\alpha < \\infty. It is shown that this \\beta-function is antisymmetric under the interchange \\alpha \\leftrightarrow 1/\\alpha and is given by the well-known perturbative expansion not only for \\alpha \\ll 1, but also for \\alpha \\gg 1. Using an idea of the Maximal Abelian Projection by t' Hooft, we considered the formation of strings - the ANO flux tubes - in the...

  6. $\\alpha_s$ from the updated ALEPH data for hadronic $\\tau$ decays

    CERN Document Server

    Boito, Diogo; Maltman, Kim; Osborne, James; Peris, Santiago


    We extract the strong coupling $\\alpha_s(m_\\tau^2)$ from the recently updated ALEPH non-strange spectral functions obtained from hadronic $\\tau$ decays. We apply a self-consistent analysis method, first tested in the analysis of OPAL data, to extract $\\alpha_s(m_\\tau^2)$ and non-perturbative contributions. The analysis yields $\\alpha_s^{\\rm FO}(m_\\tau^2)=0.296\\pm0.010 $, using Fixed Order Perturbation Theory (FOPT), and $\\alpha^{\\rm CI}_s(m_\\tau^2)= 0.310\\pm0.014$, using Contour Improved Perturbation Theory (CIPT). The weighted average of these results with those previously obtained from OPAL data give $\\alpha_s^{\\rm FO}(m_\\tau^2)=0.303\\pm 0.009$ and $\\alpha_s^{\\rm CI}(m_\\tau^2)=0.319\\pm 0.012$, which gives, after evolution to the $Z$ boson mass scale, $\\alpha^{\\rm FO}_s(m_Z^2)=0.1165\\pm0.0012 $ and $\\alpha_s^{\\rm CI}(m_Z^2)=0.1185\\pm0.0015 $, respectively. We observe that non-perturbative effects limit the accuracy with which $\\alpha_s$ can be extracted from $\\tau$ decay data.

  7. Collagen alpha5 and alpha2(IV) chain coexpression: analysis of skin biopsies of Alport patients. (United States)

    Patey-Mariaud de Serre, N; Garfa, M; Bessiéres, B; Noël, L H; Knebelmann, B


    Alport syndrome is a collagen type IV disease caused by mutations in the COL4A5 gene with the X-linked form being most prevalent. The resultant alpha5(IV) collagen chain is a component of the glomerular and skin basement membranes (SBMs). Immunofluorescent determination of the alpha5(IV) chain in skin biopsies is the procedure of choice to identify patients. In 30% of patients, however, the mutant protein is still found in the SBM resulting in a normal staining pattern. In order to minimize or eliminate false results, we compared the distribution of the alpha2(IV) chain (another SBM component) and the alpha5(IV) chain by standard double label immunofluorescence (IF) and by confocal laser scanning microscopy. The study was performed on 55 skin biopsies of patients suspected of Alports and five normal control specimens. In normal skin, IF showed the classical linear pattern for both collagens along the basement membrane. Additionally, decreased alpha5(IV) was found in the bottom of the dermal papillary basement membrane. Confocal analysis confirmed the results and show alpha5(IV) focal interruptions. In suspected patients, both techniques showed the same rate of abnormal alpha5(IV) expression: segmental in women and absent in men. Our results show a physiological variation of alpha5(IV) location with focal interruptions and decreased expression in the bottom of the dermal basement membrane. Comparison of alpha5(IV) with alpha2(IV) expression is simple and eliminates technical artifacts.

  8. Variable displacement alpha-type Stirling engine (United States)

    Homutescu, V. M.; Bălănescu, D. T.; Panaite, C. E.; Atanasiu, M. V.


    The basic design and construction of an alpha-type Stirling engine with on load variable displacement is presented. The variable displacement is obtained through a planar quadrilateral linkage with one on load movable ground link. The physico-mathematical model used for analyzing the variable displacement alpha-type Stirling engine behavior is an isothermal model that takes into account the real movement of the pistons. Performances and power adjustment capabilities of such alpha-type Stirling engine are calculated and analyzed. An exemplification through the use of the numerical simulation was performed in this regard.

  9. First Attempts at Antihydrogen Trapping in ALPHA

    CERN Document Server

    Andresen, G B; Bowe, P D; Bray, C C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Funakoshi, R; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A J; Hydomako, R; Jenkins, M J; Jørgensen, L V; Kurchaninov, L; Lambo, R; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Page, R D; Povilus, A; Pusa, P; Robicheaux, F; Sarid, E; Seif El Nasr, S; Silveira, D M; Storey, J W; Thompson, R I; Van der Werf, D P; Wasilenko, L; Wurtele, J S; Yamazaki, Y; Fujiwara, M C


    We discuss aspects of antihydrogen studies, that relate to particle physics ideas and techniques, within the context of the ALPHA experiment at CERN's Antiproton Decelerator facility. We review the fundamental physics motivations for antihydrogen studies, and their potential physics reach. We argue that initial spectroscopy measurements, once antihydrogen is trapped, could provide competitive tests of CPT, possibly probing physics at the Planck Scale. We discuss some of the particle detection techniques used in ALPHA. Preliminary results from commissioning studies of a partial system of the ALPHA Si vertex detector are presented, the results of which highlight the power of annihilation vertex detection capability in antihydrogen studies.

  10. On $\\alpha$-roughly weighted games

    CERN Document Server

    Freixas, Josep


    Very recently Gvozdeva, Hemaspaandra, and Slinko (2011) have introduced three hierarchies for simple games in order to measure the distance of a given simple game to the class of weighted voting games or roughly weighted voting games. Their third class $\\mathcal{C}_\\alpha$ consists of all simple games permitting a weighted representation such that each winning coalition has a weight of at least 1 and each losing coalition a weight of at most $\\alpha$. We continue their work and contribute some new results on the possible values of $\\alpha$ for a given number of voters.

  11. Alpha decay chains from superheavy nuclei

    CERN Document Server

    Samanta, C


    Magic islands for extra-stable nuclei in the midst of the sea of fission-instability were predicted to be around Z=114, 124 or, 126 with N=184, and Z=120, with N=172. Whether these fission-survived superheavy nuclei with high Z and N would live long enough for detection or, undergo alpha-decay in a very short time remains an open question. Alpha-decay half lives of nuclei with 130 118 are found to have alpha-decay half lives of the order of microseconds or, less.

  12. Electrochemical study of 7{alpha},12,20-O-trimethyl-conacytone in acetonitrile

    Energy Technology Data Exchange (ETDEWEB)

    Frontana, Carlos; Frontana-Uribe, Bernardo A.; Gonzalez, Ignacio


    An electrochemical study of the electroreduction in anhydrous acetonitrile of 7{alpha},12,20-O-trimethyl-conacytone, an abietane quinoid diterpene derivative from the natural product 7{alpha}-O-methyl-conacytone, showed two reduction signals. At the first reduction step, fast chemical reactions involving the loss of the methoxyl group located at C-7 with simultaneous regeneration of the quinoid moiety were observed. This electrogenerated quinone is reduced again, at the same potential used with the former quinone, resulting in a two-electron peak. These results were obtained by cyclic voltammetry and double-step chronoamperometry experiments. The electrolysis under methylating conditions of 7{alpha}-O-methyl-conacytone, at potential values of the second electron transfer, generates as major products, methoxy-hydroquinone, where the methoxy group at C-7 is lost, which is in agreement with the proposed mechanism. Therefore, the second reduction signal was attributed to the reduction of semiquinone intermediates by a mechanism not elucidated.

  13. Production of $\\alpha$-particle condensate states in heavy-ion collisions

    CERN Document Server

    Raduta, Ad R; Geraci, E; Neindre, N Le; Napolitani, P; Rivet, M F; Alba, R; Amorini, F; Cardella, G; Chatterjee, M; De Filippo, E; Guinet, D; Lautesse, P; La Guidara, E; Lanzalone, G; Lanzano, G; Lombardo, I; Lopez, O; Maiolino, C; Pagano, A; Pirrone, S; Politi, G; Porto, F; Rizzo, F; Russotto, P; Wieleczko, J P


    The fragmentation of quasi-projectiles from the nuclear reaction $^{40}Ca$ + $^{12}C$ at 25 MeV/nucleon was used to produce excited states candidates to $\\alpha$-particle condensation. The experiment was performed at LNS-Catania using the CHIMERA multidetector. Accepting the emission simultaneity and equality among the $\\alpha$-particle kinetic energies as experimental criteria for deciding in favor of the condensate nature of an excited state, we analyze the $0_2^+$ and $2_2^+$ states of $^{12}$C and the $0_6^+$ state of $^{16}$O. A sub-class of events corresponding to the direct 3-$\\alpha$ decay of the Hoyle state is isolated.

  14. 13C(alpha,n)16O background in a liquid scintillator based neutrino experiment

    CERN Document Server

    Zhao, Jie; Liu, Jianglai; Li, Xiaobo; Zhang, Feihong; Xia, Dongmei


    Alpha from natural radioactivity may interact with a nucleus and emit a neutron. The reaction introduces background to the liquid scintillator (LS) based neutrino experiments. In the LS detector, alpha comes from 238U, 232Th and 210Po decay chains. For Gadolinium-doped LS (Gd-LS) detector, alpha also comes from 227Ac. The nucleus 13C is a natural component of Carbon which is rich in the LS. The background rate and spectrum should be subtracted carefully from the neutrino candidates. This paper describes the calculation of neutron yield and spectrum with uncertainty estimated. The results are relevant for many existing neutrino experiments and future LS or Gd-LS based experiments.

  15. Lambda alpha, Sigma alpha and Xi alpha potentials derived from the SU6 quark-model baryon-baryon interaction

    CERN Document Server

    Fujiwara, Y; Suzuki, Y


    We calculate Lambda alpha, Sigma alpha and Xi alpha potentials from the nuclear-matter G-matrices of the SU6 quark-model baryon-baryon interaction. The alpha-cluster wave function is assumed to be a simple harmonic-oscillator shell-model wave function. A new method is proposed to derive the direct and knock-on terms of the interaction Born kernel from the hyperon-nucleon G-matrices, with explicit treatments of the nonlocality and the center-of-mass motion between the hyperon and alpha. We find that the SU6 quark-model baryon-baryon interactions, FSS and fss2, yield a reasonable bound-state energy for 5 He Lambda, -3.18 -- -3.62 MeV, in spite of the fact that they give relatively large depths for the Lambda single-particle potentials, 46 -- 48 MeV, in symmetric nuclear matter. An equivalent local potential derived from the Wigner transform of the nonlocal Lambda alpha kernel shows a strong energy dependence for the incident Lambda-particle, indicating the importance of the strangeness-exchange process in the o...

  16. The $^{59}$Cu(p,$\\alpha$) cross section and its implications for nucleosynthesis in core collapse supernovae

    CERN Multimedia

    The $^{59}$Cu(p,$\\alpha$) reaction is key for heavy element synthesis in the vp-process, since it may hinder the reaction flow to higher masses by recycling material back to $^{56}$Ni and it has a strong influence on the production of the cosmic X-ray sources $^{55}$Fe and $^{59}$Ni. The intense and highly energetic $^{59}$Cu beams provided by the new HIE-ISOLDE facility will for the first time allow a direct measurement of this reaction at astrophysical energies, making it one of only few cases where a direct study is possible with a radioactive beam. We propose to measure the $^{59}$Cu(p,$\\alpha$) reaction for the first time using $^{59}$Cu beams from the HIE-ISOLDE facility.

  17. Is coefficient alpha robust to nonnormal data?

    Directory of Open Access Journals (Sweden)

    Yanyan eSheng


    Full Text Available Coefficient alpha has been a widely used measure by which internal consistency reliability is assessed. In addition to essential tau-equivalence and uncorrelated errors, normality has been noted as another important assumption for alpha. Earlier work on evaluating this assumption considered either exclusively nonnormal error score distributions, or limited conditions. In view of this and the availability of advanced methods for generating univariate nonnormal data, Monte Carlo simulations were conducted to show that nonnormal distributions for true or error scores do create problems for using alpha to estimate the internal consistency reliability. The sample coefficient alpha is affected by leptokurtic true score distributions, or skewed and/or kurtotic error score distributions. Increased sample sizes, not test lengths, help improve the accuracy, bias or precision of using it with nonnormal data.

  18. The QSE-reduced $\\alpha$ Network

    CERN Document Server

    Hix, W R; Wheeler, J C; Thielemann, F K


    Examination of the process of silicon burning, the burning stage that leads to the production of the iron peak nuclei, reveals that the nuclear evolution is dominated by large groups of nuclei in mutual equilibrium. These quasi-equilibrium (QSE) groups form well in advance of the global Nuclear Statistical Equilibrium (NSE). We present an improved ``minimal'' nuclear network, which takes advantage of quasi-equilibrium in order to calculate the nuclear evolution and energy generation while further reducing the computational cost compared to a conventional \\alpha-chain network. During silicon burning, the resultant \\emph{QSE-reduced} \\alpha network is twice as fast as the full \\alpha network it replaces and requires the tracking of only half as many abundance variables, without significant loss of accuracy. When the QSE-reduced \\alpha network is used in combination with a conventional an accurate approximation for all of the burning stages from He burning to NSE, while tracking only 7 abundances. These reductio...

  19. T-branes and $\\alpha'$-corrections

    CERN Document Server

    Marchesano, Fernando


    We study $\\alpha'$-corrections in multiple D7-brane configurations with non-commuting profiles for their transverse position fields. We focus on T-brane systems, crucial in F-theory GUT model building. There $\\alpha'$-corrections modify the D-term piece of the BPS equations which, already at leading order, require a non-primitive Abelian worldvolume flux background. We find that $\\alpha'$-corrections may either i) leave this flux background invariant, ii) modify the Abelian non-primitive flux profile, or iii) deform it to a non-Abelian profile. The last case typically occurs when primitive fluxes, a necessary ingredient to build 4d chiral models, are added to the system. We illustrate these three cases by solving the $\\alpha'$-corrected D-term equations in explicit examples, and describe their appearance in more general T-brane backgrounds. Finally, we discuss implications of our findings for F-theory GUT local models.

  20. Strichartz estimates on $alpha$-modulation spaces

    Directory of Open Access Journals (Sweden)

    Weichao Guo


    Full Text Available In this article, we consider some dispersive equations, including Schrodinger equations, nonelliptic Schrodinger equations, and wave equations. We develop some Strichartz estimates in the frame of alpha-modulation spaces.

  1. Solar Imagery - Chromosphere - H-Alpha (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Collection includes a variety of H-alpha photographic datasets contributed by a number of national and private solar observatories located worldwide. Solar...

  2. Energy dependence of event shapes and of $\\alpha_s$ at LEP 2

    CERN Document Server

    Abreu, P; Adye, T; Adzic, P; Albrecht, Z; Alderweireld, T; Alekseev, G D; Alemany, R; Allmendinger, T; Allport, P P; Almehed, S; Amaldi, Ugo; Amapane, N; Amato, S; Anassontzis, E G; Andersson, P; Andreazza, A; Andringa, S; Antilogus, P; Apel, W D; Arnoud, Y; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Bambade, P; Barão, F; Barbiellini, Guido; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Beillière, P; Belokopytov, Yu A; Belous, K S; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Bertini, D; Bertrand, D; Besançon, M; Bianchi, F; Bigi, M; Bilenky, S M; Bizouard, M A; Bloch, D; Blom, H M; Bonesini, M; Bonivento, W; Boonekamp, M; Booth, P S L; Borgland, A W; Borisov, G; Bosio, C; Botner, O; Boudinov, E; Bouquet, B; Bourdarios, C; Bowcock, T J V; Boyko, I; Bozovic, I; Bozzo, M; Branchini, P; Brenke, T; Brenner, R A; Brückman, P; Brunet, J M; Bugge, L; Buran, T; Burgsmüller, T; Buschbeck, Brigitte; Buschmann, P; Cabrera, S; Caccia, M; Calvi, M; Camporesi, T; Canale, V; Carena, F; Carroll, L; Caso, Carlo; Castillo-Gimenez, M V; Cattai, A; Cavallo, F R; Chabaud, V; Chapkin, M M; Charpentier, P; Chaussard, L; Checchia, P; Chelkov, G A; Chierici, R; Chliapnikov, P V; Chochula, P; Chorowicz, V; Chudoba, J; Cieslik, K; Collins, P; Contri, R; Cortina, E; Cosme, G; Cossutti, F; Cowell, J H; Crawley, H B; Crennell, D J; Crépé, S; Crosetti, G; Cuevas-Maestro, J; Czellar, S; Davenport, Martyn; Da Silva, W; Deghorain, A; Della Ricca, G; Delpierre, P A; Demaria, N; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Min, A; De Paula, L S; Dijkstra, H; Di Ciaccio, Lucia; Dolbeau, J; Doroba, K; Dracos, M; Drees, J; Dris, M; Duperrin, A; Durand, J D; Eigen, G; Ekelöf, T J C; Ekspong, Gösta; Ellert, M; Elsing, M; Engel, J P; Erzen, B; Espirito-Santo, M C; Falk, E; Fanourakis, G K; Fassouliotis, D; Fayot, J; Feindt, Michael; Fenyuk, A; Ferrari, P; Ferrer, A; Ferrer-Ribas, E; Ferro, F; Fichet, S; Firestone, A; Flagmeyer, U; Föth, H; Fokitis, E; Fontanelli, F; Franek, B J; Frodesen, A G; Frühwirth, R; Fulda-Quenzer, F; Fuster, J A; Galloni, A; Gamba, D; Gamblin, S; Gandelman, M; García, C; Gaspar, C; Gaspar, M; Gasparini, U; Gavillet, P; Gazis, E N; Gelé, D; Ghodbane, N; Gil, I; Glege, F; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; González-Caballero, I; Gopal, Gian P; Gorn, L; Górski, M; Guz, Yu; Gracco, Valerio; Grahl, J; Graziani, E; Green, C; Grimm, H J; Gris, P; Grosdidier, G; Grzelak, K; Günther, M; Guy, J; Hahn, F; Hahn, S; Haider, S; Hallgren, A; Hamacher, K; Hansen, J; Harris, F J; Hedberg, V; Heising, S; Hernández, J J; Herquet, P; Herr, H; Hessing, T L; Heuser, J M; Higón, E; Holmgren, S O; Holt, P J; Hoorelbeke, S; Houlden, M A; Hrubec, Josef; Huet, K; Hughes, G J; Hultqvist, K; Jackson, J N; Jacobsson, R; Jalocha, P; Janik, R; Jarlskog, C; Jarlskog, G; Jarry, P; Jean-Marie, B; Johansson, E K; Jönsson, P E; Joram, C; Juillot, P; Kapusta, F; Karafasoulis, K; Katsanevas, S; Katsoufis, E C; Keränen, R; Kersevan, Borut P; Khomenko, B A; Khovanskii, N N; Kiiskinen, A P; King, B J; Kinvig, A; Kjaer, N J; Klapp, O; Klein, H; Kluit, P M; Kokkinias, P; Koratzinos, M; Kostyukhin, V; Kourkoumelis, C; Kuznetsov, O; Krammer, Manfred; Kriznic, E; Krstic, J; Krumshtein, Z; Kubinec, P; Kurowska, J; Kurvinen, K L; Lamsa, J; Lane, D W; Langefeld, P; Lapin, V; Laugier, J P; Lauhakangas, R; Leder, Gerhard; Ledroit, F; Lefébure, V; Leinonen, L; Leisos, A; Leitner, R; Lemonne, J; Lenzen, Georg; Lepeltier, V; Lesiak, T; Lethuillier, M; Libby, J; Liko, D; Lipniacka, A; Lippi, I; Lörstad, B; Loken, J G; Lopes, J H; López, J M; López-Fernandez, R; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J N; Mahon, J R; Maio, A; Malek, A; Malmgren, T G M; Maltezos, S; Malychev, V; Mandl, F; Marco, J; Marco, R P; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Martínez-Vidal, F; Martí i García, S; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Matthiae, Giorgio; Masik, J; Mazzucato, F; Mazzucato, M; McCubbin, M L; McKay, R; McNulty, R; McPherson, G; Meroni, C; Meyer, W T; Migliore, E; Mirabito, L; Mitaroff, Winfried A; Mjörnmark, U; Moa, T; Moch, M; Møller, R; Mönig, K; Monge, M R; Moreau, X; Morettini, P; Morton, G A; Müller, U; Münich, K; Mulders, M; Mulet-Marquis, C; Muresan, R; Murray, W J; Muryn, B; Myatt, Gerald; Myklebust, T; Naraghi, F; Nassiakou, M; Navarria, Francesco Luigi; Navas, S; Nawrocki, K; Negri, P; Némécek, S; Neufeld, N; Neumeister, N; Nicolaidou, R; Nielsen, B S; Nikolenko, M; Nomokonov, V P; Normand, Ainsley; Nygren, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, Risto; Orazi, G; Österberg, K; Ouraou, A; Paganoni, M; Paiano, S; Pain, R; Paiva, R; Palacios, J; Palka, H; Papadopoulou, T D; Papageorgiou, K; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Pegoraro, M; Peralta, L; Pernicka, Manfred; Perrotta, A; Petridou, C; Petrolini, A; Phillips, H T; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Privitera, P; Pukhaeva, N; Pullia, Antonio; Radojicic, D; Ragazzi, S; Rahmani, H; Ratoff, P N; Read, A L; Rebecchi, P; Redaelli, N G; Regler, Meinhard; Reid, D; Reinhardt, R; Renton, P B; Resvanis, L K; Richard, F; Rídky, J; Rinaudo, G; Røhne, O M; Romero, A; Ronchese, P; Rosenberg, E I; Rosinsky, P; Roudeau, Patrick; Rovelli, T; Royon, C; Ruhlmann-Kleider, V; Ruiz, A; Saarikko, H; Sacquin, Yu; Sadovskii, A; Sajot, G; Salt, J; Sampsonidis, D; Sannino, M; Schneider, H; Schwemling, P; Schwering, B; Schwickerath, U; Schyns, M A E; Scuri, F; Seager, P; Sedykh, Yu; Segar, A M; Sekulin, R L; Shellard, R C; Sheridan, A; Siebel, M; Simard, L C; Simonetto, F; Sissakian, A N; Smadja, G; Smirnov, N; Smirnova, O G; Smith, G R; Sopczak, André; Sosnowski, R; Spassoff, Tz; Spiriti, E; Sponholz, P; Squarcia, S; Stanescu, C; Stanic, S; Stevenson, K; Stocchi, A; Strub, R; Stugu, B; Szczekowski, M; Szeptycka, M; Tabarelli de Fatis, T; Tegenfeldt, F; Terranova, F; Thomas, J; Timmermans, J; Tinti, N; Tkatchev, L G; Todorova-Nová, S; Tomaradze, A G; Tomé, B; Tonazzo, A; Tortora, L; Tranströmer, G; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Tsirou, A L; Turluer, M L; Tyapkin, I A; Tzamarias, S; Ullaland, O; Uvarov, V; Valenti, G; Vallazza, E; Van der Velde, C; van Apeldoorn, G W; van Dam, P; Van Doninck, W K; Van Eldik, J; Van Lysebetten, A; Van Vulpen, I B; Vassilopoulos, N; Vegni, G; Ventura, L; Venus, W A; Verbeure, F; Verlato, M; Vertogradov, L S; Verzi, V; Vilanova, D; Vitale, L; Vlasov, E; Vodopyanov, A S; Vollmer, C F; Voulgaris, G; Vrba, V; Wahlen, H; Walck, C; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G R; Winter, M; Witek, M; Wolf, G; Yi, J; Yushchenko, O P; Zaitsev, A; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zevgolatakos, E; Zimin, N I; Zucchelli, G C; Zumerle, G


    Infrared and collinear safe event shape distributions and their mean values are determined using the data taken at ve di erent centre of mass energies above $M_Z$ with the DELPHI detector at LEP. From the event shapes, the strong coupling $\\alpha_s$ is extracted in $O(\\alpha^2_s)$, NLLA and a combined scheme using hadronisation corrections evaluated with fragmentation model generators as well as using an analytical power ansatz. Comparing these measurements to those obtained at MZ, the energy dependence (running) of $\\alpha_s$ is accessible. The logarithmic energy slope of the inverse strong coupling is measured to be $d\\alpha_{s}^{-1}/d log(E_{cm}) = 1.39 \\pm 0.34(stat) \\pm 0.17(syst)$, in good agreement with the QCD expectation of 1.27.

  3. Improved parametrization of the unified model for alpha decay and alpha capture

    CERN Document Server

    Denisov, V Yu; Sedykh, I Yu


    The updated data for the ground-state-to-ground-state alpha-transition half-lives in 401 nuclei and the alpha capture cross sections of 40Ca, 44Ca, 59Co, 208Pb and 209Bi are well described in the framework of the unified model for alpha-decay and alpha-capture. The updated values of the alpha decay half-lives, the binding energies of nuclei, the spins of parent and daughter nuclei, and the surface deformation parameters are used for the reevaluation of the model parameters. The data for the ground-state-to-ground-state alpha-decay half-lives are also well described by the empirical relationships.

  4. Cytokine vaccination: neutralising IL-1alpha autoantibodies induced by immunisation with homologous IL-1alpha

    DEFF Research Database (Denmark)

    Svenson, M; Hansen, M B; Thomsen, A R;


    High-affinity IgG autoantibodies (aAb) to IL-1alpha are among the most frequently found aAb to cytokines in humans. To establish an animal model with aAb to IL-1alpha, we immunised mice with recombinant murine IL-1alpha. Unprimed and Bacille Calmette-Guérin (BCG)-primed BALB/cA mice were vaccinated...... in mice by vaccination with recombinant murine IL-1alpha conjugated to PPD. Studies of the effects of IL-1alpha aAb in such animals may help clarify the importance of naturally occurring IL-1alpha aAb in humans and permit the evaluation of future therapies with cytokine aAb in patients...... with immunoinflammatory diseases and cytokine-dependent tumours....

  5. Lattice measurement of \\alpha_s with a realistic charm quark

    CERN Document Server

    Blossier, B; Brinet, M; De Soto, F; Du, X; Morenas, V; Pene, O; Petrov, K; Rodriguez-Quintero, J


    We report on an estimate of \\alpha_s, renormalised in the MSbar scheme at the tau and Z^0 mass scales, by means of lattice QCD. Our major improvement compared to previous lattice calculations is that, for the first time, no perturbative treatment at the charm threshold has been required since we have used statistical samples of gluon fields built by incorporating the vacuum polarisation effects of u/d, s and c sea quarks. Extracting \\alpha_s in the Taylor scheme from the lattice measurement of the ghost-ghost-gluon vertex, we obtain \\alpha_s^{MSbar}(m^2_Z)=0.1200(14) and \\alpha_s^{MSbar}(m^2_tau)=0.339(13).

  6. The ALPHA Experiment a Cold Antihydrogen Trap

    CERN Document Server

    Bertsche, W; Bowe, P D; Cesar, C L; Chapman, S; Charlton, M; Chartier, M; Deutsch, A; Fajans, J; Fujiwara, M C; Funakoshi, R; Gill, D; Gomberoff, K; Grote, D P; Hangst, J S; Hayano, R S; Jenkins, M; Jørgensen, L V; Madsen, N; Miranda, D; Nolan, P; Ochanski, K; Olin, A; Page, R D; Posada, L G C; Robicheaux, F; Sarid, E; Telle, H H; Vay, J L; Wurtele, J; van der Werf, D P; Yamazaki, Y


    The ALPHA experiment aims to trap antihydrogen as the next crucial step towards a precise CPT test, by a spectroscopic comparison of antihydrogen with hydrogen. The experiment will retain the salient techniques developed by the ATHENA collaboration during the previous phase of antihydrogen experiments at the antiproton decelerator (AD) at CERN. The collaboration has identified the key problems in adding a neutral antiatom trap to the previously developed experimental configuration. The solutions identified by ALPHA are described in this paper.

  7. Self-assembling, dynamic alphaPNAs

    DEFF Research Database (Denmark)

    Nielsen, Peter E


    In the recent report published in Science, Ghadiri and coworkers describe dynamic tPNAs, alphaPNA derivatives with a nucleobase attached via a thioester bond that are a step forward toward self-repairing and replicating molecules.......In the recent report published in Science, Ghadiri and coworkers describe dynamic tPNAs, alphaPNA derivatives with a nucleobase attached via a thioester bond that are a step forward toward self-repairing and replicating molecules....

  8. Selective sorting of alpha-granule proteins


    Italiano, J.E.; Battinelli, E. M.


    One of the main functions of blood platelets is to secrete a variety of substances that can modify a developing thrombus, regulate the growth of the vasculature, promote wound repair, and contribute to cell-adhesive events. The majority of this vast array of secreted proteins is stored in alpha-granules. Until recently, it was assumed that platelets contained one homogeneous population of alpha-granules that undergo complete de-granulation during platelet activation. This review focuses on th...

  9. Lectin interactions with alpha-galactosylated xenoantigens

    DEFF Research Database (Denmark)

    Kirkeby, Svend; Moe, Dennis


    alpha-Galactosylated xenoantigens (Galalpha1-3Galbeta1-4GlcNAcbeta1 and Galalpha1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc) are often detected with the alpha-Gal specific lectin Griffonia simplicifolia 1 isolectin B4 (GS1 B4). However, this lectin exhibits a broad and variable specificity for carboh...

  10. Scaling Property in the Alpha Predominant EEG

    CERN Document Server

    Lin, D C; Kwan, H; Lin, Der Chyan; Sharif, Asif; Kwan, Hon


    The $\\alpha$ predominant electroencephalographic (EEG) recording of the human brain during eyes open and closed is studied using the zero-crossing time statistics. A model is presented to demonstrate and compare the key characteristics of the brain state. We found the zero-crossing time statistic is more accurate than the power spectral analysis and the detrend fluctuation analysis. Our results indicate different EEG fractal scaling in eyes closed and open for individuals capable of strong $\\alpha$ rhythm.

  11. Measurement of the angle alpha at BABAR

    Energy Technology Data Exchange (ETDEWEB)

    Perez, A.; /Orsay, LAL


    The authors present recent measurements of the CKM angle {alpha} using data collected by the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} collider at the SLAC National Accelerator Laboratory, operating at the {Upsilon}(4S) resonance. They present constraints on {alpha} from B {yields} {pi}{pi}, B {yields} {rho}{rho} and B {yields} {rho}{pi} decays.

  12. EEG alpha power and creative ideation ☆



    Neuroscientific studies revealed first insights into neural mechanisms underlying creativity, but existing findings are highly variegated and often inconsistent. Despite the disappointing picture on the neuroscience of creativity drawn in recent reviews, there appears to be robust evidence that EEG alpha power is particularly sensitive to various creativity-related demands involved in creative ideation. Alpha power varies as a function of creativity-related task demands and the originality of...

  13. Alpha-emitters for medical therapy workshop

    Energy Technology Data Exchange (ETDEWEB)

    Feinendegen, L.E.; McClure, J.J.


    A workshop on ``Alpha-Emitters for Medical Therapy`` was held May 30-31, 1996 in Denver Colorado to identify research goals and potential clinical needs for applying alpha-particle emitters and to provide DOE with sufficient information for future planning. The workshop was attended by 36 participants representing radiooncology, nuclear medicine, immunotherapy, radiobiology, molecular biology, biochemistry, radiopharmaceutical chemistry, dosimetry, and physics. This report provides a summary of the key points and recommendations arrived at during the conference.

  14. Neurophysiological assessment of alpha pattern coma.



    Somatosensory evoked potentials, blink reflexes, and H wave reflexes, were recorded on several days from three patients with alpha pattern coma. Coma was secondary to cardiac arrest in two cases and to brainstem infarction in one. Results are compatible with damage to the brainstem reticular formation with sparing of thalamo-cortical circuits as the main physiopathological characteristic of alpha pattern coma. This condition should not be regarded as a discrete entity when establishing the pr...

  15. The cellular and behavioral consequences of interleukin-1 alpha penetration through the blood-brain barrier of neonatal rats: a critical period for efficacy. (United States)

    Tohmi, M; Tsuda, N; Zheng, Y; Mizuno, M; Sotoyama, H; Shibuya, M; Kawamura, M; Kakita, A; Takahashi, H; Nawa, H


    Proinflammatory cytokines circulating in the periphery of early postnatal animals exert marked influences on their subsequent cognitive and behavioral traits and are therefore implicated in developmental psychiatric diseases such as schizophrenia. Here we examined the relationship between the permeability of the blood-brain barrier to interleukin-1 alpha (IL-1 alpha) in neonatal and juvenile rats and their later behavioral performance. Following s.c. injection of IL-1 alpha into rat neonates, IL-1 alpha immunoreactivity was first detected in the choroid plexus, brain microvessels, and olfactory cortex, and later diffused to many brain regions such as neocortex and hippocampus. In agreement, IL-1 alpha administration to the periphery resulted in a marked increase in brain IL-1 alpha content of neonates. Repeatedly injecting IL-1 alpha to neonates triggered astrocyte proliferation and microglial activation, followed by behavioral abnormalities in startle response and putative prepulse inhibition at the adult stage. Analysis of covariance with a covariate of startle amplitude suggested that IL-1 alpha administration may influence prepulse inhibition. However, adult rats treated with IL-1 alpha as neonates exhibited normal learning ability as measured by contextual fear conditioning, two-way passive shock avoidance, and a radial maze task and had no apparent sign of structural abnormality in the brain. In comparison, when IL-1 alpha was administered to juveniles, the blood-brain barrier permeation was limited. The increases in brain IL-1 alpha content and immunoreactivity were less pronounced following IL-1 alpha administration and behavioral abnormalities were not manifested at the adult stage. During early development, therefore, circulating IL-1 alpha efficiently crosses the blood-brain barrier to induce inflammatory reactions in the brain and influences later behavioral traits.

  16. [Studies on determination of alpha-amylase with p-nitrophenyl-alpha-D-maltotetraoside]. (United States)

    Kruse-Jarres, J D; Schott, F J; Klein, B; Rastetter, N; Wallenfels, K


    Nitrophenylmaltodextrins are alpha-amylase substrates which allow a continuous determination with a zero order kinetics over a period of at least 10 min, without deviations from linearity. Only one auxiliary enzyme is necessary. Practicability and clinical evidence of alpha-amylase determinations by means of p-nitrophenyl-alpha-D-maltotetraoside are demonstrated. The interserial precision of 0.84% cannot conceal an only moderate correlation with previous methods. This fact, however, does not negate the advantages.

  17. A Further Measurement of the beta-Delayed alpha-Particle Emission of 16N

    CERN Document Server

    III, R H F; McDonald, J E; Wilds, E L


    We measured the beta-delayed alpha-particle emission spectrum of 16N with a sensitivity for beta-decay branching ratios of the order of 10-10. The 16N nuclei were produced using the d(15N,16N)p reaction with 70 MeV 15N beams and a deuterium gas target 7.5 cm long at a pressure of 1250 torr. The 16N nuclei were collected (over 10 s) using a thin aluminum foil with an areal density of 180 mu g/cm2 tilted at 7 Deg with respect to the beam. The activity was transferred to the counting area by means of a stepping motor in less than 3 s with the counting carried out over 8 s. The beta-delayed alpha-particles were measured using a time of flight method to achieve a sufficiently low background. Standard calibration sources (148Gd, 241Am, 208,209Po, and 227Ac) as well as alpha-particles and 7Li from the 10B(n,alpha)7Li reaction were used for an accurate energy calibration. The energy resolution of the catcher foil (180-220 keV) was calculated and the time of flight resolution (3-10 nsec) was measured using the beta-de...

  18. Cyclosophorohexadecaose and succinoglycan monomers as catalytic carbohydrates for the Strecker reaction. (United States)

    Lee, Sanghoo; Cho, Eunae; Kwon, Chanho; Jung, Seunho


    Some microbial carbohydrates have been used as catalysts for the multicomponent Strecker reaction using trimethylsilyl cyanide (TMSCN). Alpha-Cyclosophorohexadecaose (alpha-C16) derived from Xanthomonas species and succinoglycan monomers derived from Rhizobium species acted as catalytic carbohydrates in the mixture solutions of methanol and water. Malonaldehyde bis(phenylimine) as a substrate was completely converted (yield: 100%) into its product to 100% by both alpha-C16 and the succinoglycan monomer (M2), having acetyl, pyruvyl, and succinyl groups as substituents after 1h. The catalytic abilities of the carbohydrates were dependent on the inherent structures of the substrates used in this study, where substrate 1 having a symmetrical structure rather than the others was favorably reacted with the alpha-C16 and M2. Through this study, we suggest that the microbial carbohydrates used in this study could be expected to be environmentally-benign catalysts for the synthesis of alpha-aminonitriles.

  19. Therapeutic use of alpha-emitters

    Energy Technology Data Exchange (ETDEWEB)

    Lassmann, M. [Klinik und Poliklinik fuer Nuklearmedizin der Univ. Wuerzburg (Germany)


    In recent years there is a growing interest in the therapeutic use of {alpha}-emitters for patient treatment, {alpha}-particles have much higher energy and their range is only a few cell diameters. Their high LET and the limited ability of cells to repair DNA damage from {alpha}-radiation explain their high relative biological effectiveness and cytotoxicity. Potential {alpha}-emitting isotopes for therapeutic applications are {sup 224}Ra, {sup 223}Ra, {sup 213}Bi and {sup 211}At. The treatment with {alpha}-particles is focused upon targeted cancer therapy using radiolabeled monoclonal antibodies, on palliation of bone metastases or upon pain relief in patients with ankylosing spondylitis (AS). Examples for targeted cancer therapy are the treatment of melanoma with {sup 213}Bi and non-Hodgkin lymphoma with {sup 211}At. For metastatic bone pain palliation {sup 223}Ra was applied in a phase I clinical trial. For amelioration of pain in AS-patients {sup 224}Ra-chloride is used. This radiopharmaceutical is licensed for this particular application in Germany. Today there are some potential clinical applications for {alpha}-emitters although most of them are in the state of scientific, non-routine investigations. In-vivo dosimetry for risk assessment associated with this treatment is even more difficult to perform than for therapies using beta-emitting radiopharmaceuticals. (orig.)

  20. Laser-initiated primary and secondary nuclear reactions in Boron-Nitride (United States)

    Labaune, C.; Baccou, C.; Yahia, V.; Neuville, C.; Rafelski, J.


    Nuclear reactions initiated by laser-accelerated particle beams are a promising new approach to many applications, from medical radioisotopes to aneutronic energy production. We present results demonstrating the occurrence of secondary nuclear reactions, initiated by the primary nuclear reaction products, using multicomponent targets composed of either natural boron (B) or natural boron nitride (BN). The primary proton-boron reaction (p + 11B → 3 α + 8.7 MeV), is one of the most attractive aneutronic fusion reaction. We report radioactive decay signatures in targets irradiated at the Elfie laser facility by laser-accelerated particle beams which we interpret as due to secondary reactions induced by alpha (α) particles produced in the primary reactions. Use of a second nanosecond laser beam, adequately synchronized with the short laser pulse to produce a plasma target, further enhanced the reaction rates. High rates and chains of reactions are essential for most applications.