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Sample records for alpha inducido por

  1. ESTRÉS OXIDATIVO EN PECES INDUCIDO POR CONTAMINANTES AMBIENTALES

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    DM Ochoa

    2008-01-01

    Full Text Available el estrés oxidativo inducido por diversas clases de contaminantes como mecanismo de toxicidad ha sido un foco de interés en el campo de la toxicología acuática y ambiental durante la última década. numerosas evidencias indican que muchos de estos agentes con-taminantes al llegar a cuerpos de agua pueden desencadenar el proceso de estrés oxidativo en organismos que allí habitan, y son responsables de efectos en células y tejidos asociados a mutagénesis y carcinogénesis. el estrés oxidativo se genera cuando existe una sobrecar-ga en la formación de radicales libres o agentes prooxidantes, la cual no es debidamente compensada por los mecanismos de defensa antioxidante que posee el organismo. Los fac-tores que son importantes al momento de la presentación del proceso de estrés oxidativo en peces, así como los mecanismos de defensa contra el ataque de agentes prooxidantes y las consecuencias de dicho evento, se revisarán en el presente artículo.

  2. Influence of some exo nucleases in response to the induced genetic damage in Escherichia coli by alpha radiation; Influencia de algunas exonucleasas en respuesta al dano genetico inducido en Escherichia coli por radiacion alfa

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar M, M

    2005-07-01

    Within the strategies with those that E. coli counts to overcome to the genetic damage there is the SOS response, a group of genes that participate in repair and/or tolerance that it confers to the bacteria major opportunities of surviving. These genes are repressed and its only are expressed when it happens genetic damage. So that this system is activated it is necessary that DNA of a band exists and in this sense the double ruptures (RDB) its are not able to induce this response unless there is a previous processing. In stumps with defects in certain genes that have to do with repair of RDB (as recO, recJ and xonA) the activity of SOS is smaller than in a wild stump what suggests that these participate in the previous processes to the activation of the response. The ionizing radiation produce among other many lesions, RDB in greater or smaller proportion, depending on the ionization capacity. A parameter to evaluate this capacity is the lineal energy transfer (LET), defined as the average energy given by unit of distance travelled. In general the LET of the corpuscular radiations is a lot but high that of the electromagnetic one, for what produces bigger quantity of ionizations inside a restricted zone and it increases by this way the probability that RDB has been generated. This work has for object to infer the participation of xonA and recJ in this response and to evaluate the damage produced by ionizing radiation of different LET (alpha particles of different energies) in a stump with all the functional repair mechanisms. Its were considered two parameters: the survival and the activity of SOS evaluated by means of the chromo test. The results indicate that the activity of these exo nucleases is necessary for the repair of RDB as well as for the processing of lesions foresaw to the activation of SOS. As for the treatment with alphas of different energies is observed that so much the survival like the activity of SOS vary as the LET of the radiation changes

  3. Síndrome de neurotoxicidad inducido por opioides (NIO Opioid induced-neurotoxicity syndrome (OIN

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    M. L. Cid

    2008-12-01

    Full Text Available El síndrome de neurotoxicidad inducido por opioides (NIO es uno de los efectos adversos del uso de estos fármacos descrito en los últimos años. Su aparición de debe a la acumulación de metabolitos tóxicos, principalmente el M3 Glucurónido de la morfina; los cuáles pueden provocar hiperexcitabilidad neuronal, con desarrollo de alteraciones cognitivas, delirium, alucinaciones, mioclonias, convulsiones e hiperalgesia. Especialmente vulnerables a estos efectos son los pacientes mayores o con factores de riesgo como insuficiencia renal o deshidratación. Su manejo incluye principalmente la prevención de su aparición, con el manejo de factores precipitantes; disminución o rotación de opioides y manejo sintomático, intentando mantener siempre un buen control del dolor.The opioid induced neurotoxicity (OIN is an adverse effect for opioids use, described in the last years. Because the accumulation of toxic metabolites, especially M3 Glucuronide of morphine, cause neuronal hiperexcitability, patients can develop cognitive failure, delirium, hallucinations, myoclonus, seizures and hyperalgesia. The most vulnerable patients are old people, patients with dehydration and renal failure. Its treatment include prevention, with the management of trigger factors, decrease or change opioids and symptomatic management, trying to keep the good control of pain.

  4. Tratamiento de agrandamiento gingival inducido por fenitoina asociado a placa bacteriana

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    Carmen Julia Rovira

    2013-10-01

    Full Text Available ResumenLa ingesta de algunos medicamentos puede producir un sobre crecimiento de las encías. Se reportan medicamentos tales como los bloqueadores de los canales de calcio, inmunosupresores, anticonvulsivantes que producen estos efectos adversos. Múltiples casos de agrandamientos gingivales están asociados a la ingesta de Fenitoína. El tratamiento de los agrandamientos gingivales inducidos por drogas por lo general es quirúrgico, pero mantener un buen control de placa bacteriana puede evitar en muchos casos que se presente un exagerado aumento de volumen gingival. Se presenta un caso de agrandamiento gingival en paciente masculino de 22 años de edad, bajo tratamiento antiepiléptico con fenitoína. Al examen clínico se observó aumento del volumen gingival de forma generalizada, en maxilar superior e inferior, predominante en sector anterior, produciendo ardor y sangrado durante el cepillado y la ingestión de alimentos. Al sondaje presenta múltiples pseudobolsas en los diferentes cuadrantes. La radiografía panorámica reveló pérdida ósea moderada horizontal, predominante en el sector posterosuperior, posteroinferior y anteroinferior. El plan de tratamiento consistió en fase higiénica, instrucción y motivación en higiene oral a la madre, gingivectomía y gingivoplastía en ambos maxilares. (DUAZARY 2011 No. 2, 226 - 231Abstract The importance of endodontic treatment is to achieve a complete filling and sealing of the root canal to prevent the transport of contaminants to and from root canal, with materials compatible with the surrounding tissues. Occasionally a situation may arise in which the purpose of the maintenance of working length is compromised such as overenlargement. This situation allows the extrusion of filling materials, mainly sealer cements, causing post treatment complications such as inflammatory reactions, injury to adjacent structures (orbital pain, inferior alveolar nerve injury, headache, etc., and infections

  5. EL REFORZAMIENTO CONDICIONADO DE LA RESPUESTA PROCURADORA DE AGUA EN LA SITUACIÓN DE BEBER INDUCIDO POR EL PROGRAMA

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    CHRISTIAN LÓPEZ; Carlos A. Bruner

    2011-01-01

    Investigaciones anteriores en nuestro laboratorio mostraron que es posible establecer una discriminación operante en la situación de Beber Inducido por el Programa ( bip ), reforzando diferencialmente la respuesta que produce el agua en presencia de un estímulo arbitrario. Dado que un estimulo discriminativo simultáneamente adquiere la función de reforzador condicionado, en el presente experimento se probó esta función del estímulo durante la extinción de la respuesta que previamente pro...

  6. Lípidos transmisores y condicionamientos inducidos por cocaína: papel de las aciletanolamidas y el ácido lisofosfático

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    Luque Rojas, María Jesús

    2012-01-01

    La presente Tesis Doctoral tiene como objetivo la evaluación del papel de tres lípidos transmisores (endocannabinoides, oleiletanolamida y ácido lisofosfatídico), que están estructuralmente relacionados en la adquisición y expresión de los condicionamientos inducidos por cocaína. El primer conjunto de estudios se centró en el rol de los endocannabinoides que juegan un importante papel modulador de la neurotransmisión dopaminérgica. Es decir, el sustrato de actuación de la cocaína y por ello s...

  7. Dolor irruptivo oncológico inducido por radioterapia: ¿es posible optimizar su tratamiento?

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    L. Olay Gayoso

    2015-08-01

    Full Text Available Introducción: en el contexto de la radioterapia, el control del dolor irruptivo oncológico (DIO supone un reto especial. El DIO ha sido definido por la Sociedad Española del Dolor (SED, la Sociedad Española de Oncología Médica (SEOM y la Sociedad Española de Cuidados Paliativos (SECPAL como una exacerbación del dolor súbita y transitoria, de gran intensidad (EVA > 7 y de corta duración (inferior a 20-30 minutos, que aparece sobre la base de un dolor persistente estable cuando este se encuentra reducido a un nivel tolerable (EVA 6 en las últimas 24-48 h. Se establecieron controles en el momento basal, y a los 3, 7, 15 y 30 días. Resultados: se apreció un descenso en la media de los valores en la escala EVA según avanzó el estudio (EVA = 6 en el control 0 a EVA = 3 en el control 3, y las diferencias fueron significativas (p < 0,0001. La satisfacción con el tratamiento fue calificada como buena o excelente por el 85,3% de los pacientes y por el 92,7% de los investigadores. Conclusiones: los resultados de este estudio demuestran la eficacia del tratamiento del DIO con fentanilo sublingual en el contexto del tratamiento oncológico radioterápico, con un descenso significativo en los valores EVA frente al valor basal. La elevada satisfacción de los médicos y pacientes con este tratamiento refleja la eficacia y la comodidad del fentanilo sublingual en el control del DIO.

  8. Efecto de la cerveza frente al estrés oxidativo inducido por la adriamicina.

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    Torres Rodríguez, Mª Carmen

    2007-01-01

    RESUMEN La cerveza es una bebida alcohólica de baja graduación resultante de fermentar mediante levadura seleccionada el mosto procedente de malta de cebada, sólo o mezclado con otros productos amiláceos transformables en azúcares por digestión enzimática, cocción y aromatizado con flores de lúpulo. Los constituyentes de la cerveza provienen de sus cuatro principales materias primas, malta, lùpulo, agua y levadura. El principal componente de la cerveza es el agua, que se acompaña de otros ...

  9. Evaluación de los efectos del policosanol sobre manifestaciones del daño pulmonar inducido por monocrotalina en ratas

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    Vivian Molina

    2009-01-01

    Full Text Available La hipertensión arterial pulmonar, (HTAP enfermedad crónica que afecta frecuentemente a la población adulta, conduce a una discapacidad importante y progresiva. Las estatinas, agentes hipolipemiantes que inhiben la síntesis de colesterol mediante la inhibición competitiva de la HMG-CoA reductasa que además inhiben la proliferación de las células musculares lisas (CML, han sido referidas como una opción actual para tratar esta enfermedad. El policosanol es una mezcla de alcoholes alifáticos superiores obtenida de la cera de caña que también inhibe la síntesis de colesterol mediante la regulación indirecta de la actividad de la HMG-CoA reductasa, con acción antiproliferativa sobre las CML. Resulta racional investigar si el policosanol protege el daño pulmonar inducido en modelos experimentales en los cuales las estatinas han mostrado ser efectivas. Este estudio investigó los efectos del tratamiento oral con policosanol sobre el daño pulmonar inducido por monocrotalina (MCT en ratas. Para ello, las ratas se distribuyeron en cuatro grupos: un control negativo tratado vía subcutánea (s.c. con disolución salina y por vía oral con el vehículo tween 20/agua y tres inyectados con dosis s.c. únicas de MCT (60 mg/kg, uno tratado por vía oral con el vehículo (control positivo y dos con policosanol (20 y 200 mg/kg. Los tratamientos comenzaron el día de la inyección con MCT y se administraron por 28 d . Se cuantificó el porcentaje de supervivencia, el peso corporal, el peso del pulmón completo, la hipertrofia ventricular y se realizó el estudio histológico. La MCT aumentó significativamente el peso del pulmón, redujo significativamente el peso corporal y produjo marcada hipertrofia ventricular derecha y severa hipertrofia de la capa media arterial, mostrando la validez del modelo. Contrario a lo esperado, al compararse con los datos del control positivo, el policosanol (20 y 200 mg/kg no modificó significativamente ninguna

  10. Nivel de corte de los ELISAs para cuantificación de anticuerpos inducidos por la vacuna antimeningocócica VA-MENGOC-BC

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    Rolando Ochoa

    2001-06-01

    Full Text Available Para medir el grado de protección inducido por vacunas antimeningocócicas se ha establecido el Ensayo Bactericida en Suero (EBS y se perfeccionan otros ensayos inmunobiológicos, sin embargo, es necesario contar con pruebas sencillas como el ELISA, capaz de evaluar un gran número de muestras. Se estimó el nivel de corte de los ELISAs para la cuantificación de IgG humana contra los antígenos de VA-MENGOC-BC, vacuna antimeningocócica compuesta por vesículas proteicas de membrana externa de meningococo B y polisacárido capsular de meningococo C, con respecto a un panel de muestras de suero de lactantes, caracterizado por Ensayo Bactericida en Sangre Total (EBST. Los valores correspondientes a la máxima sensibilidad y especificidad fueron respectivamente; 2 μg/mL y 12 μg/mL para antipolisacárido C, y 1000 U/mL y 7000 U/mL para antiproteínas de membrana externa. La mayor coincidencia se obtuvo con 6 μg/mL y 2500 U/mL. Se evaluó otro panel de muestras de suero de adolescentes entre 14 y 18 años, por ELISA y EBS para Neisseria meningitidis serogrupos B y C, alcanzándose una buena concordancia. Doce años después de la inmunización con VA-MENGOC-BC persiste una importante concentración de anticuerpos contra los antígenos vacunales en los sueros estudiados.

  11. Efectos del D-004, extracto lipídico de los frutos de la Palma Real (Roystonea regia), sobre el granuloma inducido por algodón en ratas y sobre la lipoxigenasa presente en leucocitos polimorfonucleares (PMNs)

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    Menéndez, Roberto; Carvajal, Daysi; Mas, Rosa; Pérez, Yohanis; Molina, Vivian; Arruzazabala, María de Lourdes; González, Rosa María

    2006-01-01

    El D-004 es un extracto lipídico del fruto de la palma real (Roystonea regia, Arecaceae), en el cual los ácidos oleico, laurico y palmítico son los principales componentes. La administración oral inhibe significativamente la hiperplasia prostática inducida por testosterona en roedores. El objetivo del presente trabajo consistió en investigar los efectos anti-inflamatorios inducidos por el tratamiento oral con D-004 en el modelo de granuloma por algodón y sus efectos in vitro sobre la activida...

  12. Estudio del daño en el ADN inducido por compuestos polifenólicos de la dieta

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    Burgos Morón, Estefanía

    2015-01-01

    El cáncer es una enfermedad causada por la acumulación de daño en el ADN . Las células cancerosas presentan numerosas alteraciones genéticas, epigenéticas y cromosómicas, que juegan un papel fundamental en el desarrollo de la enfermedad . Estas alteraciones pueden producirse como consecuencia del propio funcionamiento celular. Por ejemplo, se sabe que las especies reactivas de oxígeno generadas durante la respiración celular y los errores cometidos por las enzimas ADN polimerasas durante la r...

  13. Dolor óseo inducido por cáncer metastásico: fisiopatología y tratamiento

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    Isaías Salas-Herrera

    2004-03-01

    Full Text Available Se estima que de un 60 a 84% de los pacientes con cáncer desarrollan metástasis óseas. De estos un 70% experimentan síndrome s dolorosos de difícil manejo, de los cuales un 50% muere sin un adecuado alivio del dolor con una pobre calidad de vida. Por tanto, es necesario contar con medicamentos accesibles y efectivos para el manejo de esta patología. El objetivo de este artículo es revisar la fisiopatología del dolor en hueso y describir los medicamentos que se utilizan con más frecuencia en el manejo de este tipo de dolor por cáncer. Además se presenta un algoritmo de 6 pasos que permite orientar al médico al momento de tomar una decisión terapéutica.

  14. Dolor óseo inducido por cáncer metastásico: fisiopatología y tratamiento

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    Isaías Salas-Herrera; Luis Carlos Huertas-Gabert

    2004-01-01

    Se estima que de un 60 a 84% de los pacientes con cáncer desarrollan metástasis óseas. De estos un 70% experimentan síndrome s dolorosos de difícil manejo, de los cuales un 50% muere sin un adecuado alivio del dolor con una pobre calidad de vida. Por tanto, es necesario contar con medicamentos accesibles y efectivos para el manejo de esta patología. El objetivo de este artículo es revisar la fisiopatología del dolor en hueso y describir los medicamentos que se utilizan con más frecuencia en e...

  15. Cambios morfológicos inducidos por terapia génica con factor de crecimiento insulino-símil tipo I (IGF-I) prolactinomas experimentales

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    Camihort, Gisela; Luna, Georgina; Hereñu, Claudia Beatriz; Bracamonte, María; Rodolfo G Goya; Cónsole, Gloria Miriam

    2010-01-01

    Analizar los cambios morfológicos y funcionales que produce la terapia génica, implementada mediante inyección intrapituitaria de un vector adenoviral RAd-IGFI, sobre las diferentes poblaciones pituitarias en prolactinomas E-inducidos

  16. Daño inducido en el ADN plasmidial por la radiación mixta de neutrones térmicos + rayos gamma en presencia y ausencia de capturador de radicales libres

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    Maritza Rodríguez-Gual

    2010-01-01

    Full Text Available En este trabajo se cuantifica por primera vez el daño en ADN plasmidial inducido por la radiación mixta de neutrones térmicos + rayos gamma. Para el estudio fue utilizado el plasmidio pBs KS+ de 2 961 pb en disolución acuosa a 88 ng/¿L a concentraciones de 0, 2 y 20 mmol/L de glicerina que actúa como un capturador de radicales libres. Este plasmidio cambia su forma superenrollada para circular cuando es producida una rotura simple en su cadena y adquiere una forma linear cuando se produce una rotura doble en su cadena. Cuantificando las fracciones que se producen de cada una de estas formas es posible estimar el efecto de la radiación en el ADN. Las irradiaciones fueron realizadas en el canal radial # 3 del reactor de investigaciones IEA-R1 del Instituto de Pesquisas Energéticas y Nucleares de São Paulo, Brasil. Las formas del ADN fueron separadas mediante la electroforesis en gel de agarosa. En la cuantificación se utilizó el programa GelAnalis. Las fracciones de ADN en sus diferentes formas fueron graficadas en función de la dosis y ajustadas a funciones exponenciales y lineares para obtener las probabilidades de roturas simples y dobles en la cadena de ADN normalizadas por dosis y por masa molecular. Los resultados evidenciaron la acción protectora del capturador de radicales libres contra el daño inducido por la radiación, lo cual corrobora resultados anteriores obtenidos con otras radiaciones ionizantes. Los rendimientos de SSB y DSB serán de interés para la validación de diferentes modelos que intentan reproducir los resultados experimentales.

  17. Medición del daño genético inducido por el basuco en linfocitos humanos empleando la prueba de micronúcleos con Citocalasina B

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    Ocampo AP.

    2001-06-01

    Full Text Available El bazuco es una mezcla compleja que se deriva del proceso de extracción de la cocaína. El frecuente consumo de bazuco constituye un problema de salud pública. La prueba de micronúcleos en linfocitos humanos de sangre periférica por bloqueo de la citocinesis con Citocalasina B, es más sensible y precisa para evaluar daño  cromosómico porque permite registrar micronúcleos originados de fragmentos de cromosomas o cromosomas enteros en células que se han dividido una sola vez. El objetivo del presente estudio fue evaluar el daño genético, inducido por el bazuco en linfocitos humanos in vitro empleando la prueba de micronúcleos con Citocalasina B.

  18. Efectos de las Ramificaciones y de los Edificios en los Voltajes Inducidos por Rayos en Líneas de Distribución Urbanas The Effects of Line Laterals and Nearby Buildings on Lightning-Induced Voltages in Urban Distribution Lines

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    A. Piantini

    2004-01-01

    Full Text Available Se presentan algunos resultados experimentales, de los efectos de las ramificaciones y de los edificios cercanos, en los voltajes inducidos por rayos en líneas de distribución urbanas. Usando un modelo en escala reducida de 1:50, las pruebas fueron realizadas considerando una típica configuración de línea de distribución, incluyendo la simulación del conductor neutral, ramificaciones, edificios y equipos como los pararrayos y transformadores. Se presentan comparaciones entre voltajes inducidos en los terminales de alto voltaje del transformador para diferentes alturas de los edificios y situaciones del transformador. Los resultados muestran que en algunas circunstancias las ramificaciones y la presencia de estructuras cercanas a la línea pueden afectar significativamente los voltajes inducidos por descargas atmosféricasSome experimental results are presented from research on the effects of laterals and nearby buildings on the lightning-induced voltages in urban overhead distribution lines. By making use of a 1:50 scale model, tests were performed considering a typical distribution line configuration, including the simulation of the neutral conductor, laterals, buildings, and equipment such as arresters and transformers. Comparisons between voltages induced at the HV transformer terminals are presented for different building heights and transformer locations. The results show that in some circumstances the laterals and the presence of structures close to the lines may significantly affect the induced voltages

  19. Efecto protector de los isotiocianatos y organosulfurados solos o en combinación con la vitamina C frente al daño al DNA inducido por la N-nitrosopiperidina y la N-nitrosobutilamina: mecanismos de acción

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    García Pérez, Almudena

    2010-01-01

    El objetivo de este trabajo de investigación consistió en evaluar el “Efecto protector de los compuestos isotiocianatos (ITCs) y de los organosulfurados (OSCs) solos o en combinación con la vitamina C frente al daño al DNA inducido por la N-nitrosopiperidina (NPIP) y la N-nitrosodibutilamina (NDBA). Así como, en determinar los mecanismos de acción por los que estos compuestos ejercen su efecto protector”. Los resultados obtenidos mostraron que las N-nitrosaminas causan daño alquilativo y oxid...

  20. Papel de p38-MAPK en el proceso de apoptosis inducido por cisplatino en células epiteliales de túbulo renal

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    Rodríguez García, María Elena

    2008-01-01

    El cisplatino es un agente alquilante de ADN con probada eficacia en el tratamiento de tumores sólidos y algunas formas de leucemia. Sin embargo, una de las principales desventajas de las terapias basadas en su uso es su nefrotoxicidad, debido al daño y a la muerte de células del epitelio tubular. En este trabajo se analiza la regulación de MAPKs (proteínas quinasas activadas por mitógenos) y su relación con el proceso de apoptosis provocado por cisplatino en células renales. Se observa que, ...

  1. Receptores de la prostaglandina E2 implicados en los trastornos motores digestivos y la fiebre inducidos por endotoxinas en la oveja: Papel de los macrófagos

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    Gimeno Soriano, Aurora; Plaza Carrión, Miguel Ángel; Castro López, Marta

    2014-01-01

    El objetivo general de este trabajo ha sido el estudio de los mecanismos fisiopatológicos implicados en la fiebre y en las alteraciones motoras digestivas inducidas por una endotoxina bacteriana: el lipopolisacárido (LPS) de Escherichia coli en la oveja. Se ha estudiado la participación de los receptores de la prostaglandina (PG) E2 (EP1, EP2, EP3 y EP4), los tipos celulares que están implicados en la síntesis y liberación de PGs en el hipotálamo y bulbo raquídeo y la posible participación de...

  2. Deterioro cognitivo inducido por privación de sueño : efecto de la edad y tratamiento con memantina.

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    Tarragón Cros, Ernesto

    2013-01-01

    La esperanza de vida y la prevalencia de enfermedades neurodegenerativas asociadas a la edad continua in crescendo, por lo que el deterioro cognitivo asociado al envejecimiento y la perdida de memoria son problemas acuciantes en el ámbito de la salud. La memantina, antagonista de los receptores NMDA de glutamato, es un fármaco de elección en la enfermedad de Alzheimer. Los objetivos de esta tesis son, pues: i) investigar el efecto de la edad y la privación de sueño en un modelo animal de ...

  3. Efecto del precondicionamiento oxidativo con Ozono en el daño intestinal inducido por isquemia/reperfusión en ratas

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    Danae Basanta Fortes; Zullyt Zamora Rodríguez; Yaima Martínez; Esmir Camps Calzadilla; Mercedes Gámez Fonseca; Víctor Rodríguez Sosa; Daisy Ferrer Marrero

    2010-01-01

    La isquemia/reperfusión intestinal constituye un fenómeno común en múltiples situaciones clínicas, tales como: la isquemia mesentérica, el shock hemorrágico y el trasplante de intestino, entre otras. La gran cantidad de alteraciones fisiopatológicas que lo acompañan contribuyen al daño irreversible del órgano. El ozono posee propiedades muy importantes, dentro de las cuales se destaca su capacidad antioxidante, razón por la cual se investigó si era capaz de proteger al intestino contra el dañ...

  4. EFECTO NEFROPROTECTOR DEL ÁCIDO ASCÓRBICO EN UN MODELO DE DAÑO RENAL INDUCIDO POR GENTAMICINA EN CONEJOS

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    Javier Antonio Padilla Funes

    2013-08-01

    Full Text Available Objetivo. Uno de los efectos secundarios mas notables de la Gentamicina es su nefrotoxicidad. En este estudio se propone el posible efecto nefroprotector del acido ascorbico como barredor de radicales libres de oxigeno. Metodología. Se ejecuto un estudio experimental en 24 conejos machos, raza Nueva Zelanda, cuyo peso fue de 1,5 +/- 0,5 Kg. Los sujetos experimentales fueron distribuidos en tres grupos. El grupo Control se manejo con Gentamicina a dosis de 80 mg/Kg/dia por via IM. El grupo Acido Ascorbico se trato a dosis de 200 mg/kg/dia via IP y Gentamicina 80mg/Kg/dia IM. El grupo Sham se manejo con SSN 0,9% por via IP e IM, durante cinco dias consecutivos, para cada grupo. Se determinaron los siguientes parametros: creatinina serica, N-Acetil s-D glucosaminidasa urinaria (NAG-U, diuresis e histopatologia de las muestras renales. Resultados. La creatinina serica fue significativamente mayor para el grupo Control respecto al grupo Acido Ascorbico (p<0,05. Respecto a la diuresis, se observo una tendencia a la poliuria en el grupo Control. En cuanto a NAG-U, se observo inhibicion completa de la actividad enzimatica en el grupo Acido Ascorbico. El analisis histopatologico demuestra hallazgos de necrosis tubular aguda en el 100% del grupo control, mientras que en el grupo Acido Ascorbico se obtuvo en un 50% de los sujetos unicamente detritos intraluminales. Conclusiones. La administracion concomitante de Acido Ascorbico con Gentamicina, disminuye significativamente el dano tubular renal, evidenciado en los valores de creatinina serica, NAG, diuresis e histopatologia renal.

  5. EFECTO NEFROPROTECTOR DEL ÁCIDO ASCÓRBICO EN UN MODELO DE DAÑO RENAL INDUCIDO POR GENTAMICINA EN CONEJOS

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    Javier Antonio Padilla Funes

    2012-01-01

    Full Text Available Objetivo. Uno de los efectos secundarios más notables de la Gentamicina es su nefrotoxicidad. En este estudio se propone el posible efecto nefroprotector del ácido ascórbico como barredor de radicales libres de oxígeno. Metodología. Se ejecutó un estudio experimental en 24 conejos machos, raza Nueva Zelanda, cuyo peso fue de 1,5 +/- 0,5 Kg. Los sujetos experimentales fueron distribuidos en tres grupos. El grupo Control se manejó con Gentamicina a dosis de 80 mg/Kg/día por vía IM. El grupo Ácido Ascórbico se trató a dosis de 200 mg/kg/día vía IP y Gentamicina 80mg/Kg/día IM. El grupo Sham se manejó con SSN 0,9% por vía IP e IM, durante cinco días consecutivos, para cada grupo. Se determinaron los siguientes parámetros: creatinina sérica, N-Acetil ß-D glucosaminidasa urinaria (NAG-U, diuresis e histopatología de las muestras renales. Resultados. La creatinina sérica fue significativamente mayor para el grupo Control respecto al grupo Ácido Ascór- bico (p<0,05. Respecto a la diuresis, se observó una tendencia a la poliuria en el grupo Control. En cuanto a NAG-U, se observó inhibición completa de la actividad enzimática en el grupo Ácido Ascórbico. El análisis histopatológico demuestra hallazgos de necrosis tubular aguda en el 100% del grupo control, mientras que en el grupo Ácido Ascórbico se obtuvo en un 50% de los sujetos únicamente detritos intraluminales. Conclusiones. La administración concomitante de Ácido Áscórbico con Gentamicina, disminuye significativamente el daño tubular renal, evidenciado en los valores de creatinina sérica, NAG, diuresis e histopatología renal.

  6. ANÁLISIS DE LOS EFECTOS INDUCIDOS POR UN PROGRAMA DE ENTRENAMIENTO PLIOMÉTRICO DE CUATRO SEMANAS DE DURACIÓN.

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    J. A. de Paz Fernández

    2010-10-01

    Full Text Available

     

    El objetivo de nuestro trabajo fue valorar las adaptaciones inducidas por un programa de entrenamiento pliométrico del tren inferior de 4 semanas de duración (12 sesiones, aplicado a 9 estudiantes de educación física (19.33±1.38 años, 74.89±6.89Kg, contando también con un grupo control (N=8. El grupo experimental mostró mejoras en la altura de salto vertical en diferentes test (SJ, CMJ y Abalakov, fuerza máxima isométrica de extensión de rodilla y potencia pico en cicloergómetro (test de Wingate, si bien ninguno de estos incrementos fue estadísticamente significativo. El grupo control no mostró mejoras en ningún test. El hecho de que los incrementos no alcanzasen significación estadística pudo deberse a la escasa duración del programa aplicado, en comparación con los programas citados en la literatura.
    PALABRAS CLAVE: Pliometría, Drop Jump, capacidad de salto, test de Wingate.

  7. Perfil sociodemográfico del aborto inducido

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    Cabezas-García Evelio

    1998-01-01

    Full Text Available Objetivo. Identificar características sociodemográficas y su fuerza de asociación con el aborto inducido del primer embarazo. Material y métodos. Se realizó un estudio analítico con la información de una encuesta realizada en el municipio Diez de Octubre, de la ciudad de La Habana, en Cuba, durante todo el año de 1991 y el primer semestre de 1992. La población de estudio se dividió en dos grupos de comparación: uno formado por las mujeres cuyo primer embarazo terminó en un aborto inducido y el otro constituido por aquellas cuyo embarazo llegó a término. De las variables estudiadas que mostraron diferencias estadísticamente significativas se obtuvieron las razones de momios crudas y ajustadas por la variable que se consideró como confusora: la edad. Para esta última fase del análisis se utilizó la regresión logística multivariada. Resultados. Las características sociodemográficas identificadas como factores de riesgo asociados al aborto inducido del primer embarazo fueron la edad menor de 24 años (aunque el riesgo se incrementa en las menores de 20 años y ser solteras o unidas. Conclusiones. El riesgo de recurrir a la práctica del aborto inducido en el primer embarazo es elevado en mujeres muy jóvenes que aún no han cumplido sus expectativas profesionales, laborales y relacionadas con el matrimonio. Estas razones parecen incompatibles con la maternidad en el grupo de mujeres estudiadas.

  8. Factores de riesgo de los trastornos hipertensivos inducidos por el embarazo en mujeres atendidas en una entidad de salud de Santa Marta

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    Gisela Esther González Ruiz

    2014-03-01

    Full Text Available Title: Risk factors hypertensive disorders induced pregnancy in women attended in a health company Santa Marta.Los trastornos hipertensivos del embarazo, son un problema de salud pública, la primera causa de muerte materna en países desarrollados y la tercera en países en desarrollo. Objetivo: Identificar los factores de riesgos que determinan la aparición de los trastornos hipertensivos, en mujeres embarazadas atendidas en una entidad de salud de Santa Marta, Colombia, en los meses de enero de 2011 a enero 2012. Materiales y métodos: estudio descriptivo, cuantitativo retrospectivo, realizado a un grupo de 51 pacientes gestantes que presentaron trastornos hipertensivos. Las técnicas de recolección de información se basaron en la revisión documental (historias clínicas y la aplicación de una encuesta previamente validada por expertos. A través de estos métodos se consignaron variables que permitieron identificar los factores en los trastornos hipertensivos de las gestantes. Resultados: la distribución por edad se ubicó en el rango 26 a 34 años (54.8%, los factores de riesgos presentes fueron: bajo peso (45.0%, no asistencia a controles prenatales (11,8%, multiparidad (56.9%, nivel socioeconómico medio-alto (45.1, antecedentes familiares relacionados con alteración hipertensiva de la madre (39.2%, antecedentes personales patológicos de infecciones urinarias (83.3% y consumo de alcohol (58.8%. Conclusiones: los factores de riesgo de antecedentes personales patológicos de infecciones urinarias se presentaron en un alto porcentaje (83,3%, el consumo de alcohol, multiparidad y antecedentes familiares, ocuparon un lugar importante; mientras que el nivel significativo de asistencia a controles prenatales, no evitó la aparición del trastorno hipertensivo. (DUAZARY 2013 No. 2, 119 - 126AbstractThe Hypertensive disorders of pregnancy are a public health problem, is the first cause of maternal death in the developed countries and the

  9. Cambios en la distribución de cultivos y producciones ganaderas en España inducidos por la nueva PAC

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    Júdez, Lucinio

    2008-12-01

    Full Text Available This paper analyses the impact on the Spanish agricultural sector of the CAP decoupling measures of direct payments for different crop areas and livestock.

    The study is based in the 2002 data from the Spanish Farm Accountancy Data Network (FADN and the simulated results are obtained with the mathematical programming model PROMAPA. The predicted changes in prices between the years 2002 and 2013 were those provided by the European Simulation Model (ESIM.

    The results obtained permit the comparison of the variation in the crop distribution and of the different types of livestock between the base year 2002 and the simulated year 2013 in the event of the implementation of a partial decoupling policy —as adopted in Spain in 2006— or a full decoupling policy which is under consideration at the moment.

    This paper also compares the variations which appear in the two types of decoupling with those that would be obtained in the even of a continuation of the Agenda 2000 measures.

    En este trabajo se analiza el impacto sobre el sector agrario español de las medidas de la Política Agraria Común de desacoplamiento de ayudas directas a las superficies sembradas de distintos cultivos y a las cabezas de ganado.

    El análisis se hace en base a los datos de 2002 de la Red Contable Nacional Agraria y a los resultados simulados para 2013 con el modelo de programación matemática PROMAPA, utilizando la predicción de variacion de precios entre 2002 y 2013 del modelo europeo de simulación ESIM.

    Los resultados obtenidos permiten comparar los cambios en la distribución de cultivos y de distintas categorías de ganado entre el año base 2002 y el año simulado, 2013, según se siga una política de desacoplamiento parcial, como la implantada en España en 2006, o una política de desacoplamiento total sobre la que se está reflexionando actualmente.

    En este trabajo se comparan, por otra

  10. Asma induzida pelo exercício: aspectos atuais e recomendações Asma inducido por el ejercicio: aspectos actuales y recomendaciones Exercise-induced asthma: current aspects and recommendations

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    Orlando Laitano

    2007-02-01

    Full Text Available OBJETIVO: Descrever os mecanismos da asma induzida pelo exercício (AIE, bem como os efeitos de diferentes tipos de treinamento físico na função pulmonar e nas capacidades aeróbia e anaeróbia. Destaca-se a importância de um diagnóstico correto mediante o teste de exercício e, no manejo, o uso de drogas beta-adrenérgicas e anticolinérgicas. FONTE DOS DADOS: Os artigos foram criteriosamente escolhidos utilizando as bases de dados PubMed e Scielo pelo ano de publicação e dando preferência a ensaios clínicos randomizados, com critérios de seleção da amostra bem definidos. SÍNTESE DOS DADOS: Os mecanismos para explicar a AIE permanecem sem conclusão, mas parece haver uma interação fisiológica entre as hipóteses aqui apresentadas. O uso de medicamentos e as freqüentes crises durante o exercício aparecem como fatores limitantes para a prática de exercícios físicos, conduzindo para um estilo de vida sedentário. CONCLUSÃO: Deve-se incentivar a prática de exercícios devidamente prescritos e minimizar as restrições aos sujeitos com AIE.OBJETIVO: Describir los mecanismos del asma inducido por el ejercicio (AIE, así como los efectos de diferentes tipos de entrenamiento físico sobre la función pulmonar y las capacidades aeróbica y anaeróbica. Se destaca la importancia de un diagnóstico correcto mediante el test de ejercicio y el manejo o uso de drogas beta-adrenérgicas y anticolinérgicas. FUENTES: Los artículos fueron cuidadosamente escogidos utilizando las bases de dados de PubMed y Scielo por el año de publicación, dando preferencia a ensayos clínicos randomizados, con criterios de selección de muestra bien definidos. SÍNTESES DE DATOS: Los mecanismos para explicar la AIE permanecen sin conclusión, pero parece haber una interacción fisiológica entre las hipótesis aquí presentadas. El uso de medicamentos y las frecuentes crisis durante el ejercicio aparecen como factores limitantes para la práctica de

  11. Actividad antioxidante de la melatonina sobre el hígado graso inducido por etionina en ratones Antioxidant activity of melatonin on fatty liver induced by ethionine in mice

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    SM Ferraro

    2008-01-01

    Full Text Available La finalidad de este estudio fue determinar la actividad antioxidante de la melatonina (MLT sobre el estrés oxidativo hepático (EOH inducido por etionina en ratones hembras y su efecto sobre la actividad de la enzima antioxidante glutatión peroxidasa (GPx. A 20 ratones se les administró MLT disuelta en etanol al 1% en dosis de 3 mg/kg p.v. vía intraperitoneal, durante 15 días y a los controles etanol 1%. Al día 13 a ambos grupos se indujo hígado graso por inyección de etionina 7,5 mg/0,02kg. Después de 48 horas de ayuno los animales fueron sacrificados y los hígados disecados. Una muestra se utilizó para análisis histopatólogico y en el sobrenadante obtenido de un homogeneizado se determinó malondialdehído (MDA, dienos conjugados (DC, triglicéridos (TG y la enzima GPx. Se realizó prueba "t" (P ≤ 0,05. Las concentraciones de TG, MDA y DC fueron menores en el grupo con MLT respecto al control (P The aim of this study was to determine the antioxidant activity of melatonin in female mice with ethionine-induced hepatic oxidative stress (HOS, and the effect of this hormone on the gluthatione peroxidase enzyme antioxidant activity. Twenty adult female NMRI mice were given intraperitoneally 3 mg/kg melatonin in 1% ethanol daily for 15 days, and 1% ethanol to the control group. On the 13th day of treatment, fatty liver was induced to both groups using 7.5 mg/0.02 kg ethionine. After 48 hours of food restriction, mice were sacrificed and livers dissected and sampled. Fixed tissue was used for hystopathologic analyses, and the supernatant obtained from an homogenated was used to determine concentrations of malondialdehyde (MDA, conjugate dienes (DC, triglycerides (TG and gluthatione peroxidase enzyme (GPx. Data were processed through SPSS vlO.O for Windows using the "t" test (P ≤ 0.05, and the results were expressed as X ± SD in mg TG, nm MDA and nm DC/mg proteins and per g of humid tissue and mU/mg proteins for GPx. Concentrations

  12. Alteraciones del desarrollo embrionario, poliaminas y estrés oxidativo inducidos por plaguicidas organofosforados en Rhinella Arenarum Alterations in embryonic development, polyamines and oxidative stress induced by organophosphates in Rhinella arenarum

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    Cecilia Inés Lascano

    2009-07-01

    Full Text Available Los plaguicidas organofosforados (OP son masivamente aplicados en el Alto Valle de Río Negro y Neuquén, afectando al ecosistema. Utilizamos un modelo embrionario de anfibios (Rhinella arenarum para estudiar mecanismos por los cuales OP como metilazinfos (MA y clorpirifos (CP podrían provocar teratogénesis. Los embriones fueron desarrollados en diferentes concentraciones de MA o CP hasta opérculo completo (OC, analizando: malformaciones, histología, glutatión reducido (GSH y enzimas antioxidantes, poliaminas, actividad de ornitina-decarboxilasa (ODC y proteínaquinasa- C (PKC. Ambos OP provocaron un incremento tiempo/concentración-dependiente de malformaciones, llegando a 100% de teratogénesis en estadios avanzados y a las mayores concentraciones, incluyendo: exogastrulación, curvaturas de aleta caudal, acortamiento axial, edema, y atrofia branquial. Se evidenció una condición de estrés oxidativo creciente: las enzimas GSH-dependientes (S-transferasa (GST, peroxidasa y reductasa fueron inducidas tempranamente a bajas concentraciones, pero inhibidas en el estadio de OC a altas concentraciones, junto con una caída significativa de GSH (62% para MA. MA incrementó significativamente (18X la actividad de ODC en OC, aumentando los niveles de putrescina (60% pero disminuyendo espermidina (56% y espermina (100%; CP disminuyó en estadios tempranos la actividad de ODC y niveles de poliaminas. La disminución de poliaminas podría deberse al incremento de degradación por poliamino-oxidasa, contribuyendo al estrés oxidativo inducido por OP. Esto causaría la disminución de GSH, y la activación de PKC en OC (55%, que participaría en el control positivo de GST y ODC. Finalmente, el estrés oxidativo y la disminución en los niveles de poliaminas podrían ser causantes de alteraciones del desarrollo embrionario.Organophosphate (OP pesticides are widely applied in the region of Alto Valle de Río Negro y Neuquén, affecting the ecosystem. We

  13. ¿CÓMO CAMBIA EL CEREBRO UN ABORTO INDUCIDO?

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    Natalia López Moratalla

    2012-01-01

    Full Text Available Estudios epidemiológicos cuantitativos muestran un riesgo entre moderado y muy alto de trastornos psiquiátricos tras el aborto inducido, especialmente de conductas adictivas e ideación de suicidio. Las mujeres que se habían sometido a un aborto experimentaron tienen un 81% más de riesgo de problemas de salud mental. Y cerca del 10% de la incidencia de problemas de salud mental se demostró que es atribuible al aborto. Siempre son más altos y sobre todo más duraderos que los que pudieran producirse por un aborto espontáneo. El embarazo no deseado no provoca trastornos y no se ha encontrado que el aborto inducido se asocie a mejor evolución de la salud mental, por lo que no puedan invocarse, sobre bases empíricas, razones de salud mental de la embarazada para inducir un aborto. Estudios de neuroimagen han mostrado que el trastorno de estrés postraumático, que sufren algunas mujeres tras el aborto voluntario, alterara las áreas cerebrales que regulan las emociones negativas, y de la memoria emocional. Los médicos deben transmitir el estado actual de ausencia de datos relacionados con los beneficios del aborto, además de informar detenidamente sobre los riesgos para la salud mental estadísticamente validados.

  14. Síndrome do coração partido (Síndrome de Takotsubo induzida por ecocardiograma de estresse com dobutamina Síndrome del corazón roto (síndrome de Tako-Tsubo inducido por ecocardiograma de esfuerzo con dobutamina Dobutamine stress echocardiography-induced broken heart syndrome (Takotsubo Syndrome

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    Francisco Juarez Cruz de Vasconcelos Filho

    2009-07-01

    Full Text Available Relatamos um caso de síndrome de Takotsubo induzida por ecocardiograma de estresse com dobutamina em uma paciente de 76 anos, hipertensa com queixas clínicas de dor precordial, em consulta cardiológica eletiva. Para exclusão de dor torácica de etiologia coronariana foi solicitado ecocardiograma de estresse com dobutamina. O exame foi realizado e, no pico do esforço máximo, o ecocardiograma mostrou acinesia apical com o eletrocardiograma mostrando supradesnivelamento do segmento ST em D1, AVL e V2. A paciente foi internada e submetida a coronariografia, que mostrou coronárias normais e VE com balonamento apical. A paciente evoluiu estável com reversão do quadro 21 dias após o quadro inicial.Relatamos un caso de síndrome de Tako-Tsubo inducido por ecocardiograma de esfuerzo con dobutamina en una paciente de 76 años, hipertensa con quejas clínicas de dolor precordial, en consulta cardiológica electiva. Para exclusión de dolor torácico de etiología coronaria se solicitó ecocardiograma de esfuerzo con dobutamina. El examen fue realizado, y en el pico de esfuerzo máximo, el ecocardiograma mostró acinesia apical con el electrocardiograma mostrando supradesnivel del segmento ST en D1, AVL y V2. La paciente fue internada y sometida a coronariografía, que mostró coronarias normales y VI con abombamiento apical. La paciente evolucionó estable con reversión del cuadro 21 días después del cuadro inicial.We report a case of dobutamine stress echocardiography-induced Takotsubo syndrome in a 76-year-old hypertensive patient with clinical complaints of chest pain in an elective visit to the cardiologist. Dobutamine-stress-echocardiography was requested to rule out chest pain of coronary origin. During the test, at peak exercise, echocardiogram showed apical akinesia and electrocardiogram showed ST-segment elevation in D1, AVL, and V2. The patient was hospitalized and underwent coronary angiography, which showed normal coronary arteries

  15. El té verde en la quimioprevención in vivo del daño genotóxico inducido por metales cancerígenos (cromo [VI] Green tea and its role on chemoprevention in vivo of genotoxic damage induced by carcinogenic metals (Chromium [VI

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    M. C. García-Rodríguez

    2012-08-01

    Full Text Available Introducción: Debido a sus componentes antioxidantes, al consumo de infusiones de té verde se le ha asociado con efectos benéficos para la salud, ya que sus antioxidantes pueden jugar un papel importante en el riesgo y la patogénesis de algunas enfermedades crónicas, como algunos tipos de cáncer y enfermedades cardiovasculares. A su vez, se ha reportado que compuestos metálicos como los del Cr [VI] son carcinogénicos e inducen daño genotóxico mediante Estrés Oxidante (EOx. De ahí que, es posible que el té verde proteja del daño genotóxico inducido por estos compuestos. Objetivo: Se evaluó el efecto de la administración por vía oral del té verde sobre el daño genotóxico inducido por Cr [VI], mediante la cuantificación de micronúcleos (MN en eritrocitos policromáticos (EPC. Material y método: Ratones de la cepa CD-1 fueron divididos en forma aleatoria en los siguientes grupos: (i testigo, (ii tratados con té verde, (iii tratados con trióxido de cromo, (iv tratados con té verde y trióxido de cromo. El té verde se administró por sonda intragástrica cada 12 horas durante dos días (4 dosis de 0,25 ml de infusiones de 1,6 g/7,5 ml y ad libitum 5,6 ml/día durante 10 días de infusiones de 3,2 g/100 ml, mientras que, el trióxido de cromo se aplicó por vía intraperitoneal (20 mg/kg. Se obtuvieron muestras de sangre de la vena caudal, en las que se evaluó el número de MN en EPC a las 0, 24, 48 y 72 horas después de los tratamientos. Resultados: El grupo tratado con té verde no presentó cambios estadísticamente significativos en los promedios de MN. Por su parte, el grupo al que se le administró el trióxido de cromo mostró incrementos entre 4 y 8 MN, que resultaron estadísticamente significativos al compararlos con el grupo testigo, lo que corroboró el daño genotóxico. Cuando se combinaron los tratamientos del té verde y trióxido de cromo se observó una disminución en las frecuencias de MN del 31 y 62% a

  16. Efectos de la administración de un inhibidor de la recaptación de serotonina, Sertralina, sobre los cambios inducidos por el estrés prenatal

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    Figueiredo Pereira de, Inês

    2016-01-01

    [ES] En las postrimerías del siglo pasado, se constató una vez más que las alteraciones causadas por estrés y ansiedad en la sociedad moderna, se encuentran entre los problemas de salud más comunes. Según la Organización Mundial de Salud (OMS), al menos el 25% de los adultos sufrirá alguna forma de trastornos por ansiedad en algún momento de su vida (Gordon y Hen, 2004; Anacker y cols., 2010), siendo las mujeres más susceptibles a este tipo de trastornos (Olff y cols., 2007). ...

  17. Diferentes estados de maduración de los frutos de Roystonea regia afectan su efecto sobre el aumento del tamaño de la próstata inducido por testosterona en ratas

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    Arruzazabala, María de Lourdes; Molina, Vivian; Carbajal, Daisy; Más, Rosa; González Canavaciolo, Víctor L.; Rodríguez, Eduardo J.; Marrero Delange, David

    2008-01-01

    En este trabajo se han comparado los efectos de extractos lipídicos obtenidos de los frutos de Roystonea regia de diferentes estados de maduración sobre la hiperplasia prostática inducida por testosterona en ratas. Frutos maduros, pintones y verdes fueron colectados y procesados para la obtención de extractos lipídicos, cuyo contenido de ácidos grasos fue analizado por cromatografía gaseosa. A medida que los frutos maduran la concentración de ácido láurico aumenta y el oleico disminuye, mient...

  18. Efecto de la Movilización Neuromeníngea en la influencia de la fatigabilidad y daño muscular inducido por el ejercicio en jóvenes deportistas de alto rendimiento: estudio piloto

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    Sobrino Senovilla, Miguel

    2015-01-01

    Trabajo Fin de Grado (TFG) INTRODUCCIÓN : El Fútbol - Sala se caracteriza por su alta demanda fisiológica . Esto se ve acrecentado en el deporte de élite, donde a l ritmo inherente de la competición, le acompaña el componente psicol ógico del jugador. El alto nivel de exigencia en su conjunto, puede desembocar en una disminución del rendimiento deportivo, detrimento de las capacidades físicas y con ello condicionar la aparición de la le...

  19. Cambios morfológicos en la población somatotropa inducidos por terapia génica neonatal con el vector RAd-FTS en ratones nude

    OpenAIRE

    Rodolfo G Goya; Cónsole, Gloria Miriam; Martínez, E. V.; Bracamonte, María; Luna, Georgina; Reggiani, Paula Cecilia

    2010-01-01

    Se ha detectado un eje bidireccional timo-pituitario, hallándose receptores de GH en las células epiteliales tímicas. La GH estimularía la secreción de timulina, mientras que los niveles bajos de timulina circulante en período prenatal inducirían hipopituitarismo. El presente estudio tiene por objetivo: implementar una terapia génica mediante el vector adenoviral RAd-FTS en ratones inmunodeficientes, con el fin de prevenir cambios en la población somatotropa.

  20. Medición del daño genético inducido por el basuco en linfocitos humanos empleando la prueba de micronúcleos con citocalasina b

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    Ocampo AP.; Carvajal SM.; Hoyos LS.

    2011-01-01

    El bazuco es una mezcla compleja que se deriva del proceso de extracción de la cocaína. El frecuente consumo de bazuco constituye un problema de salud pública. La prueba de micronúcleos en linfocitos humanos de sangre periférica por bloqueo de la citocinesis con Citocalasina B, es más sensible y precisa para evaluar daño  cromosómico porque permite registrar micronúcleos originados de fragmentos de cromosomas o cromosomas enteros en células que se han dividido una sola vez. El objetivo del pr...

  1. Estudio de los efectos de agentes anticolinérgicos y de inhibidores de fosfodiesterasa-5 sobre la estructura pulmonar en un modelo experimental de enfermedad pulmonar obstructiva crónica inducido por humo de tabaco en el cobayo

    OpenAIRE

    Domínguez Fandos, David

    2015-01-01

    Tesi realitzada a l'Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) / Fundació Clinic per la Recerca Biomèdica La enfermedad pulmonar obstructiva crónica (EPOC) es una patología prevenible caracterizada por una limitación al flujo aéreo progresiva y no completamente reversible, disnea, producción de esputo y tos crónica. La obstrucción al flujo aéreo se asocia a un proceso inflamatorio crónico en la vía aérea y el parénquima pulmonar en respuesta a partículas nocivas...

  2. Efectos de los aceites de almendras dulces y de crisálida del gusano de la seda sobre el fotoenvejecimiento cutáneo inducido en ratones SKH1/CRL por radiación UV

    OpenAIRE

    Gil Ortega, Ana María

    2014-01-01

    La piel es el órgano más extenso del organismo y puede sufrir, además del envejecimiento cronológico, el denominado fotoenvejecimiento o envejecimiento cutáneo patológico. Está caracterizado por un envejecimiento cutáneo más extenso y sobre todo, de mayor gravedad, pues engloba la fotocarcinogénesis o presentación de cánceres cutáneos. Desde la Antigüedad, el hombre tuvo conciencia de la importancia del Sol en su vida, pero también de sus efectos indeseables. En la actualidad las sociedad...

  3. Chromosomal aberrations induced by alpha particles; Aberraciones cromosomicas inducidas por particulas {alpha}

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, C.; Brena V, M. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: cgc@nuclear.inin.mx

    2005-07-01

    The chromosomal aberrations produced by the ionizing radiation are commonly used when it is necessary to establish the exposure dose of an individual, it is a study that is used like complement of the traditional physical systems and its application is only in cases in that there is doubt about what indicates the conventional dosimetry. The biological dosimetry is based on the frequency of aberrations in the chromosomes of the lymphocytes of the individual in study and the dose is calculated taking like reference to the dose-response curves previously generated In vitro. A case of apparent over-exposure to alpha particles to which is practiced analysis of chromosomal aberrations to settle down if in fact there was exposure and as much as possible, to determine the presumed dose is presented. (Author)

  4. Aborto espontâneo e provocado: sentimentos vivenciados pelos homens Aborto espontáneo y inducido: sentimientos vivenciados por hombres Spontaneous and induced abortion: feelings experienced by men

    Directory of Open Access Journals (Sweden)

    Márcia Melo Laet Rodrigues

    2006-02-01

    Full Text Available A incorporação da perspectiva masculina na assistência em saúde reprodutiva é recomendada em nível mundial. Esta pesquisa teve como objetivo conhecer os sentimentos vivenciados por homens que compartilharam a experiência do aborto com suas parceiras. A análise da narrativa foi o método empregado. Narrativas de 17 homens foram analisadas para identificar os principais sentimentos relacionados à vivência. Os principais sentimentos associados ao aborto espontâneo estavam relacionados à angústia da perda e ao aborto provocado, à culpabilidade diante do ocorrido e suas conseqüências. Homens que compartilham da experiência do aborto requerem sensibilidade e envolvimento dos profissionais, suas principais demandas estavam relacionadas ao desejo do acolhimento, obtenção de suporte emocional e informações completas e precisas sobre o processo.La incorporación de la perspectiva masculina en la asistencia en salud reproductiva es recomendada en el ámbito mundial. El objetivo de esta investigación fue conocer los sentimientos vividos por hombres que compartieron la experiencia del aborto con sus compañeras. El método fue el análisis de la narrativa. Las narrativas de 17 hombres fueron analizadas para identificar los principales sentimientos relacionados a las vivencias. Los principales sentimientos relacionados al aborto espontáneo estaban relacionados a la angustia de la pérdida y frente al aborto provocado la culpabilidad delante de lo ocurrido y sus consecuencias. Hombres que compartieron la experiencia del aborto requieren sensibilidad y compromiso de los profesionales, las principales demandas estaban relacionadas al deseo de acogimiento, obtención del soporte emocional e informaciones completas y precisas sobre el proceso.The insertion of male perspective in reproductive health is an international recommendation. The aim of this research was to know the men's feelings related to the abortion shared with their partners

  5. Cambios inducidos por la implantación de olivos sobre las propiedades edáficas en el sur bonaerense Changes induced by tree olives implantation on soil properties in southern bonaerense

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    María del Carmen Blanco

    2005-12-01

    Full Text Available El reemplazo de la estepa graminosa nativa por montes de olivos (Olea europaea L. en pequeños sectores del sur pampeano afectados al cultivo de trigo ha introducido una modificación drástica en la vegetación como factor pedogenético activo. El impacto de este cambio se evaluó en el horizonte A de los suelos predominantes (Paleustolles Petrocalcicos bajo montes de olivos (LV2 implantados hace aproximadamente 50 a��os y se lo comparó con el ocasionado por la rotación tradicional trigo (LV3-vegetación natural (LV1. Se determinó: textura, densidad aparente (Da, pH, carbono orgánico (CO, nitrógeno total (Nt, fósforo disponible (Pd, CIC, bases intercambiables y, además, se estudió la organización micromorfológica. El efecto del cambio de vegetación es notable en las tres situaciones comparadas, no obstante, las variables químicas y la micropedología no reflejan disminución de la calidad del suelo a partir de la introducción de olivos.In small sectors of the southern Pampean region affected by wheat cultivation, the native grassland steppe has been replaced by Olea europaea L. mounts, which introduced a drastic modification of vegetation as an active factor of pedogenesis. The impact of this change was evaluated in the A horizons of the predominant soils (Petrocalcic Paleustolls under olives mounts of approximately 50 years (LV2 and has been compared to that derived after the traditional rotation wheat (LV3-native vegetation (LV1. Chemical analyses were performed to analyze the variables commonly used in the evaluation of soil fertility: bulk density (Da, texture, pH, organic carbon (CO, total nitrogen (Nt, available phosphorous (Pd, CIC, exchangeable bases. Moreover, a micromorphological study was done. Increments of 90% magnitude order in CO content, 70% in Nt and >100% in Pd were detected under olive trees cultivation related to a high biomass of olive trees and grass vegetation in the epipedon and to the intense

  6. Efectos "in vivo" de Metformina sobre las alteraciones de la microarquitectura sea asociadas al Sndrome Metablico inducido por fructosa en ratas In vivo effects of Metformin on the alterations of bone micro-architecture associated with fructose-induced Metabolic Syndrome in rats

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    J.I Felice

    2011-10-01

    Full Text Available El Sndrome Metablico (SM se ha asociado recientemente con una disminucin en la densidad mineral sea, y con un aumento en la incidencia de fracturas osteoporticas. Recientemente encontramos que la Metformina por va oral en ratas, promueve la diferenciacin osteognica de clulas progenitoras de mdula sea e incrementa la reparacin de lesiones seas. En este trabajo evaluamos los efectos del SM inducido por Fructosa sobre la microarquitectura sea en ratas, y la modulacin de estos efectos por Metformina administrada en forma oral. Utilizamos ratas Sprague Dawley macho jvenes: C (control sin tratamiento, C+M (100mg/kg/da Metformina en el agua de bebida, F (10 % Fructosa en el agua de bebida y F+M (Fructosa+Metformina en el agua de bebida. Los tratamientos se continuaron por 3 semanas luego de lo cual se tomaron muestras de sangre, previas al sacrificio de los animales. Se disecaron los fmures para evaluacin histomorfomtrica de la microarquitectura metafisaria por tincin con Hematoxilina-Eosina (H-E. Se observ un incremento en la glucemia y trigliceridemia en el grupo F versus el C, compatible con el desarrollo de SM. El anlisis de las metfisis femorales mostr un aumento en la densidad osteoctica trabecular para el grupo C+M (118 % del control, pSeveral clinical studies have demonstrated that the Metabolic Syndrome (MS is associated with a decrease in bone mineral density, and with an increased risk for non-vertebral osteoporotic fractures. We have recently found that orally administered Metformin induces osteogenic effects in rats, promoting osteoblastic differentiation of bone marrow progenitor cells and increasing the repair of bone lesions. In the present work we have evaluated the effects of Fructose-induced MS on bone micro-architecture in rats, and the possible modulation of these effects by orally administered Metformin. We utilized young male Sprague-Dawley rats, divided into four groups: C (non-treated controls; C+M (100 mg/kg/day of Metformin

  7. Agrandamiento gingival inducido por nifedipina.Reporte de un caso

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    Antonio José Díaz Caballero

    2013-10-01

    Full Text Available ResumenEs bien conocido que el tratamiento con diversos tipos de medicamentos puede producir en las encías un crecimiento de este tejido. Se reporta que medicamentos tales como los bloqueadores de los canales de calcio, inmunosupresores, anticonvulsivantes pueden expresar esos efectos laterales. La nifedipina es la que principalmente se reporta que produce agrandamientos gingivales, al ser utilizada durante tratamientos largos para trastornos cardiovasculares, angina de pecho e hipertensión. Se presenta un caso de paciente varón de 60 años de edad, hipertenso, tratado con nifedipina, con agrandamientos gingivales. Se realiza fase higiénica y terapia quirúrgica con electro cirugía. La evolución y predecibilidad fueron favorables. (Duazary 2009 I; 51-55AbstractIt is well known that chronic medication with various drugs may cause gingival overgrowth. It has been reported that gingival overgrowth is induced by drugs such as calcium channel blockers and immunosuppressants. Nifedipine is most frequently reported to induce gingival overgrowth during long-term treatment of cardiovascular disorders such as hypertension and angina pectoris. A case of a 60 year old male patient with hypertension treated with nifedipine is presented. Electrosurgery treatment was performed; the evolution and prediction are favorable.Key Words: Nifedipine; Gingival Overgrowth; Calcium Cannel Blocker.

  8. Sincretismo mitológico inducido por contacto

    NARCIS (Netherlands)

    J. Gómez Rendón

    2013-01-01

    The present study explores an almost untrodden field in the structuralist mythemic analysis, according to which a myth is a narrative matrix that may and should be read along a diachronic axis. This perspective highlights socio-historical aspects of mythopoesis as mirrored on the matter and pattern

  9. Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia La mifepristona inhibe el crecimiento de carcinomas mamarios inducidos por MPA o por FGF2 pero no las hiperplasias mamarias inducidas por FGF2

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    Juan P. Cerliani

    2010-12-01

    Full Text Available We have previously demonstrated a crosstalk between fibroblast growth factor 2 (FGF2 and progestins inducing experimental breast cancer growth. The aim of the present study was to compare the effects of FGF2 and of medroxyprogesterone acetate (MPA on the mouse mammary glands and to investigate whether the antiprogestin RU486 was able to reverse the MPA- or FGF2-induced effects on both, mammary gland and tumor growth. We demonstrate that FGF2 administered locally induced an intraductal hyperplasia that was not reverted by RU486, suggesting that FGF2-induced effects are progesterone receptor (PR-independent. However, MPA-induced paraductal hyperplasia was reverted by RU486 and a partial agonistic effect was observed in RU486-treated glands. Using C4-HD tumors which only grow in the presence of MPA, we showed that FGF2 administered intratumorally was able to stimulate tumor growth as MPA. The histology of FGF2-treated tumors showed different degrees of gland differentiation. RU486 inhibited both, MPA or FGF2 induced tumor growth. However, only complete regression was observed in MPA-treated tumors. Our results support the hypothesis that stromal FGF2 activates PR inducing hormone independent tumor growth.Hemos demostrado previamente que la vía de señalización del factor de crecimiento fibroblástico 2 (FGF2 interactúa con la vía de los receptores de progesterona (RP induciendo el crecimiento del cáncer de mama experimental, y hemos postulado que el FGF2 estromal activaría los RP en los tumores hormono independientes. El objetivo de este trabajo es comparar los efectos del FGF2 y del acetato de medroxiprogesterona (MPA en la glándula mamaria de ratón e investigar si el antiprogestágeno RU486 induce la regresión del tumor hormono dependiente C4-HD que crece con MPA o con la administración intratumoral de FGF2. Demostramos que la administración diaria local de FGF2 induce una hiperplasia intraductal mamaria que no es revertida por el

  10. Efeito da administração do atracúrio sobre a recuperação do bloqueio neuromuscular induzido pelo pancurônio Efecto de la administración del atracúrio sobre la recuperación del bloqueo neuromuscular inducido por el pancuronio Effect of atracurium on pancuronium-induced neuromuscular block recovery

    Directory of Open Access Journals (Sweden)

    Luís Fernando Rodrigues Maria

    2004-06-01

    diminuição de 20% no tempo de recuperação total.JUSTIFICATIVA Y OBJETIVOS: Frecuentemente en cirugías abdominales, en la fase de cerramiento de la pared, hay necesidad de dosis adicionales de bloqueador neuromuscular. El objetivo de este estudio fue analizar, en la vigencia de recuperación parcial del bloqueo neuromuscular inducido por el pancuronio, el efecto de la administración de dosis complementares de atracúrio sobre la recuperación espontanea del bloqueo neuromuscular. MÉTODO: Fueron estudiados 30 pacientes, divididos en dos grupos, 14 pacientes formaron el grupo pancuronio y 16 pacientes, el grupo atracúrio. La función neuromuscular fue monitorizada de forma continua por acelerometria del músculo aductor del pulgar, utilizando la secuencia de cuatro estímulos (SQE, a través de la estimulación supramáxima del nervio ulnar. La inducción de la anestesia fue hecha con propofol, fentanil, pancuronio 0,08 mg.kg-1 y la manutención con N2O 60% en oxígeno e isoflurano en la concentración expirada de 0,5%. Cuando la primera contracción de la secuencia de cuatro estímulos (T1 recuperó 25%, el grupo pancuronio recibió pancuronio 0,025 mg.kg-1 y el grupo atracúrio, 0,20 mg.kg-1 de atracúrio. Después de la dosis complementar fueron anotados los tiempos para recuperación espontanea de T1 igual a 10%, 25%, 75%, del índice de recuperación (IR25-75% y de la relación T4/T1 igual a 0,8. RESULTADOS: Los tiempos de recuperación espontanea después de la dosis complementar de pancuronio o atracúrio no divergieron cuando evaluados por la recuperación de T1 en 10% (45,00 ± 15,50 vs 49,69 ± 9,41, 25% (61,64 ± 18,58 vs 64,25 ± 12,51 y 75% (94,00 ± 28,52 vs 84,69 ± 16,50. El IR25-75% (32,36 ± 13,76 vs 20,44 ± 9,24 y el tiempo de recuperación de la relación T4/T1 = 0,8 (176,86 ± 29,57 vs 141,50 ± 29,57 fueron mayores en el grupo en que la complementación fue realizada con pancuronio. CONCLUSIONES: En las condiciones de este estudio, la

  11. Perfil sociodemográfico del aborto inducido Sociodemographic profile of induced abortion

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    Evelio Cabezas-García

    1998-05-01

    Full Text Available Objetivo. Identificar características sociodemográficas y su fuerza de asociación con el aborto inducido del primer embarazo. Material y métodos. Se realizó un estudio analítico con la información de una encuesta realizada en el municipio Diez de Octubre, de la ciudad de La Habana, en Cuba, durante todo el año de 1991 y el primer semestre de 1992. La población de estudio se dividió en dos grupos de comparación: uno formado por las mujeres cuyo primer embarazo terminó en un aborto inducido y el otro constituido por aquellas cuyo embarazo llegó a término. De las variables estudiadas que mostraron diferencias estadísticamente significativas se obtuvieron las razones de momios crudas y ajustadas por la variable que se consideró como confusora: la edad. Para esta última fase del análisis se utilizó la regresión logística multivariada. Resultados. Las características sociodemográficas identificadas como factores de riesgo asociados al aborto inducido del primer embarazo fueron la edad menor de 24 años (aunque el riesgo se incrementa en las menores de 20 años y ser solteras o unidas. Conclusiones. El riesgo de recurrir a la práctica del aborto inducido en el primer embarazo es elevado en mujeres muy jóvenes que aún no han cumplido sus expectativas profesionales, laborales y relacionadas con el matrimonio. Estas razones parecen incompatibles con la maternidad en el grupo de mujeres estudiadas.Objective. To identify sociodemographic characteristics associated with induced abortion of the first pregnancy and quantify the strength of association between them. Material and methods. Data were gathered from a survey conducted in the district of Diez de Octubre, Havana, Cuba throughout 1991 and the beginning of 1992. The study population was divided into two comparable groups: one group of women whose first pregnancy terminated in induced abortion and a second group of women whose pregnancy terminated in childbirth. For the

  12. Sincronización de la ovulación y el ciclo inducido por el efecto "macho" mediante la administración de progesterona por vía intravaginal en cabras en período de anestro estacional

    OpenAIRE

    Mogedas Moreno, María

    2016-01-01

    Algunos de los métodos alternativos a los tratamientos hormonales clásicos utilizando progestágenos y eCG, para la inducción y sincronización del celo y la ovulación, unido a la inseminación artificial (IA) a tiempo fijo en ganado caprino, están basados como el IMA.PRO2® en el estímulo por la presencia de los machos (efecto macho) y la sincronización de la ovulación inducida mediante prostaglandina F2α o sus análogos. En estos métodos, la administración de una dosis baja de progesterona o pro...

  13. ¿CÓMO CAMBIA EL CEREBRO UN ABORTO INDUCIDO?

    OpenAIRE

    Natalia López Moratalla

    2012-01-01

    Estudios epidemiológicos cuantitativos muestran un riesgo entre moderado y muy alto de trastornos psiquiátricos tras el aborto inducido, especialmente de conductas adictivas e ideación de suicidio. Las mujeres que se habían sometido a un aborto experimentaron tienen un 81% más de riesgo de problemas de salud mental. Y cerca del 10% de la incidencia de problemas de salud mental se demostró que es atribuible al aborto. Siempre son más altos y sobre todo más duraderos que los que pudieran ...

  14. Efectos inducidos por Ruta graveolens L., Cnidoscolus chayamansa McVaugh y Citrus aurantium L. sobre los niveles de glucosa, colesterol y triacilglicéridos en un modelo de rata diabética Efeitos induzidos por Ruta graveolens L., Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, e Citrus aurantium L., Rutaceae, nos níveis de glucose, colesterol e triacilglicerídeos num modelo do rato diabético Induced effects by Ruta graveolens L., Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, and Citrus aurantium L., Rutaceae, on glucose, cholesterol and triacylglycerides levels in a diabetic rat model

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    Lauro Figueroa-Valverde

    2009-12-01

    Full Text Available Varias plantas con propiedades hipoglucemicas se han utilizado en medicina popular y sistemas curativos tradicionales en todo el mundo. El propósito de este trabajo fue evaluar los efectos inducidos por Ruta graveolens L., Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, y Citrus aurantium L., Rutaceae, en un modelo de rata diabética, a la que se le cuantificaron los niveles de glucosa cada 24 horas por un mes después de la administración gástrica del extracto de las plantas. Además, el colesterol y los triglicéridos fueron evaluados usando técnicas enzimáticas. Los resultados mostraron que la administración de Cnidoscolus chayamansa a dosis de 0.5 a 1.5 g/kg induce un aumento hipoglucemico ( 200 mg/dL. Otros resultados, mostraron que Citrus aurantium ejerce cambios en la concentración de triacilglicéridos (158-172 mg/dL y colesterol (120-128 mg/dL. Finalmente, la administración de Ruta graveolens a dosis de 0.5 g/kg induce un efecto hipoglucemico (Diversas plantas com propriedades hipoglicêmicas foram usadas na medicina popular e em sistemas tradicionais de curas em torno do mundo. A finalidade deste trabalho foi avaliar os efeitos induzidos por Ruta graveolens L, Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, e Citrus aurantium L., Rutaceae, em modelo do rato diabético onde níveis da glucose foram determinados a cada 24 h em um mês antes da administração gástrica do extrato das plantas. Colesterol e triacilglicerídeos foram avaliados usando técnicas enzimáticas. Os resultados mostraram que a administração de Cnidoscolus chayamansa a dose de 0,5 a 1,5 g/kg induz um aumento hipoglicêmico ( 200 mg/dL. Outros resultados, mostraram que Citrus aurantium exerce mudanças na concentração de triacilglicerídeos (158-172 mg/dL e colesterol (120-128 mg/dL. Finalmente, a administração de Ruta graveolens na dose de 0.5 g/kg induziu um efeito hipoglicêmico (Several plants with hypoglycemic properties have

  15. Neutron-induced alpha radiography; Radiografia com particulas alfa induzida por neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Marco Antonio Stanojev

    2008-07-01

    A new radiography technique to inspect thin samples was developed. Low energy alpha particles, generated by a boron based screen under thermal neutron irradiation, are used as penetrating radiation. The solid state nuclear track detector CR-39 has been used to register the image. The interaction of the {alpha} - particles with the CR-39 gives rise to damages which under an adequate chemical etching became tracks the basic units forming the image. A digital system was developed for data acquisition and data analysis as well as for image processing. The irradiation and etching conditions to obtain the best radiography are 1,3 hours and 25 minutes at 70 deg C respectively. For such conditions samples having 10 {mu}m in thickness can be inspected with a spatial resolution of 32 {mu}m. The use of the digital system has reduced the time spent for data acquisition and data analysis and has improved the radiography image visualization. Furthermore, by using the digital system, it was possible to study several new parameters regarding the tracks which are very important to understand and study the image formation theory in solid state nuclear track detectors, the one used in this thesis. Some radiography images are also shown which demonstrate the potential of the proposed radiography technique. When compared with the other radiography techniques already in use to inspect thin samples, the present one developed in the present paper allows a smaller time to obtain the image, it is not necessary to handle liquid radioactive substances, the detector is insensitive to {beta}, {gamma}, X-ray and visible light. (author)

  16. Mineral and/or milk supplementation of fruit beverages helps in the prevention of H2O2-induced oxidative stress in Caco-2 cells La adición de minerales y/o leche a bebidas a base de zumo de frutas ayuda en la prevención del estrés oxidativo inducido por H2O2 en celulas Caco-2

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    A. Cilla

    2011-06-01

    aporte de numerosos compuestos bioactivos que pueden actuar de forma aditiva o sinérgica frente al estrés oxidativo. Objetivos: Evaluar si la adición de hierro, cinc y leche a las bebidas a base de zumo de frutas no afecta al efecto cito-protector frente al daño oxidativo en células Caco-2 a través de la inducción de enzimas del ciclo del GSH y la preservación de la progresión del ciclo celular, en comparación con la bebida a base de zumo de frutas no suplementada. Métodos: Las células Caco-2 se incubaron 24 h con las fracciones bioaccesibles (FB de ocho bebidas a base de zumo de frutas con/sin hierro y/o cinc y/o leche, y se sometieron a estrés oxidativo con H2O2 (5 mmol L-1-2 h. Se determinó la actividad enzimática mitocondrial (test MTT, la actividad de las enzimas GSH-Rd y GSH-Px, la progresión del ciclo celular y la actividad de la enzima caspasa-3. Resultados y discusión: Las bebidas a base de zumo de frutas previnieron del efecto perjudicial del H2O2 sobre la viabilidad celular, con casi todas las muestras alcanzando los niveles basales del control. Sólo la adición independiente de hierro o cinc con/sin leche ejerció efectos positivos sobre la actividad de la enzima GSH-Rd. Por otra parte, ambos minerales con leche proporcionaron una mejor preservación en la actividad de la enzima GSH-Px. Todas las muestras previnieron el descenso en la fase G1 del ciclo celular inducido por el H2O2, excepto la muestra adicionada de hierro, pero ninguna de ellas evitó el incremento en la fase subG1 del ciclo celular. Sin embargo, este hecho no estuvo asociado con la actividad de la enzima caspasa-3, con un probable efecto positivo del cinc sobre este parámetro. Conclusión: La adición de minerales y/o leche a las bebidas a base de zumo de frutas ayuda en la prevención de estrés oxidativo en células Caco-2 mediante el mantenimiento de la viabilidad celular, activación de enzimas del ciclo del GSH, preservación de la progresión del ciclo celular e

  17. Análisis de los cambios en la expresión génica inducidos por el tratamiento con pseudoterosina en la línea celular de cáncer de mama MDA-MB231

    OpenAIRE

    Siabatto Fernandez, Helbert David

    2015-01-01

    De acuerdo a cifras publicadas por la Organización Mundial de la Salud, el cáncer de mama es una de las patologías con mayor porcentaje de mortalidad e incidencia en las mujeres, y en este sentido es necesario el desarrollo de nuevas alternativas para su tratamiento (Saucedo, 2013). Hoy en día están en uso clínico al menos 121 fármacos antineoplásicos que no cubren todas las necesidades de tratamiento, y es pertinente continuar investigando nuevas moléculas activas que presenten mayor efecti...

  18. Beneficial effect of Berberis buxifolia Lam, Ziziphus mistol Griseb and Prosopis alba extracts on oxidative stress induced by chloramphenicol Efecto benéfico de extractos de Berberis buxifolia Lam, Zizyphus mistol Griseb y Prosopis alba sobre el estrés oxidativo inducido por cloramfenicol

    Directory of Open Access Journals (Sweden)

    Claudia Albrecht

    2010-02-01

    Full Text Available The chemiluminescence of luminol, a measure of oxidative stress, increased immediately as a consequence of reactive oxygen species (ROS stimulated by this antibiotic. The effect of Ch was dose dependent with maximum stimulus at 8 mg/ml (Vmax; above this concentration the cells began to reduce the production of ROS. The oxidative injury of Ch was counteracted by water extracts of Berberis buxifolia lam, Zizyphus mistol Griseb and Prosopis alba, indigenous fruits from Argentina. The relatively light units (RLU emitted decreased immediately as a consequence of a protective effect exerted by the extracts of these fruit extracts on blood cells. The three indigenous fruit extracts reduced to a different extent the oxidative injury caused by Ch. B.buxifolia lam exhibited the highest antioxidant capacity followed by Z.mistol Griseb. Water extracts of both fruit extracts were the most effective against the oxidative stress, while P.alba presented better antioxidant capacity in the ethanolic fraction obtained. Hexane extracts showed low protective action on blood cells, with little reduction of area under curve (AUC of RLU plotted versus time. Leukocytes remained viable in blood samples incubated for 3h with Ch and water extracts of B. buxifolia lam or Z. mistol Griseb (97.1% and 92.5% viability by Trypan blue exclusion, respectively; whereas with Ch only the cells were stressed and viability decreased to 30%. The three fruit extracts protected the viability of leukocytes in parallel with the decrease of ROS. Erythrocytes were not lysed in the presence of Ch.Se estudió el efecto antioxidante de tres extractos de frutas autóctonas, Berberis buxifolia lam (michay, Zizyphus mistol Griseb (mistol and Prosopis alba (algarrobo. Las células sanguíneas humanas sufrieron estrés oxidativo por acción de cloramfenicol (Ch, con un aumento inmediato de especies reactivas del oxígeno (ERO, que fue determinado por quimioluminiscencia con luminol. La respuesta fue

  19. Respuesta de anticuerpos inducidos por la vacuna antimeningocócica cubana VA-MENGOC-BC® frente a la cepa de Neisseria meningitidis B:4:P1.19,15 en adolescentes después de 12 años de inmunizados

    Directory of Open Access Journals (Sweden)

    María A. Camaraza

    2006-12-01

    Full Text Available Se estudió la respuesta de anticuerpos inducida por la vacuna antimeningocócica cubana VA-MENGOC-BC® contra la cepa de Neisseria meningitidis B:4:P1.19,15 mediante el Ensayo Bactericida del Suero (EBS y ELISA de tipo indirecto, para medir anticuerpos contra vesículas de membrana externa (VME de N. meningitidis B a 184 adolescentes de un politécnico de Ciego de Ávila que fueron inmunizados en campañas masivas 12 años antes. Se realizaron extracciones de sangre antes de aplicar la primera dosis (T0, 4 semanas después de ésta (T1 y 4 semanas después de la segunda dosis (T2. Transcurridos 12 años de esta vacunación el 42% de los adolescentes presentó títulos bactericidas ≥ 1:4 frente a la cepa homóloga (B:4:P1.19,15 y el 98% mostró anticuerpos detectables contra las VME. En el EBS; el porcentaje de seroconversión T1/T0 fue del 57% y T2/T0 del 60%. Mediante ELISA la seroconversión fue del 59% y 54%, respectivamente, por lo que se demostró que la aplicación de una sola dosis después de 12 años indujo una respuesta inmune importante que puede sugerir una respuesta anamnésica.

  20. Clínicas del dolor y cuidados paliativos en México: manejo del estreñimiento inducido por opiáceos. Conclusiones de un grupo de expertos Pain clinics and palliative care in Mexico: management of opioid-induced constipation. Conclusions of an expert group

    Directory of Open Access Journals (Sweden)

    J.A. Flores Cantisani

    2009-12-01

    Full Text Available A finales de septiembre de 2008, 15 líderes de opinión en el tratamiento del dolor y los cuidados paliativos de México se reunieron en la ciudad de México con el objetivo de elaborar una guía clínica acerca del uso de opiáceos y sus efectos secundarios, con especial acento en el estreñimiento, y se propuso un nuevo esquema de tratamiento. Los participantes trabajan actualmente en unidades de dolor o de paliativos por todo México y algunos son participante activos en la elaboración de medidas reguladoras sobre el uso de opiáceos. Durante la elaboración de esta guía, se ha publicado la Ley de Reforma del Tratamiento Paliativo de México, que ha entrado en vigor el 6 de enero de 2009.At the end of September 2008, 15 leading figures in pain treatment and palliative care in Mexico met in Mexico City to design a clinical guideline on the use of opioids and the secondary effects of these drugs, with special emphasis on constipation. A new treatment scheme was proposed. The participants currently work in pain or palliative care units throughout Mexico and some are active participants in the design of regulatory measures on opioid use. During the drafting of this guideline, the law reforming palliative treatment in Mexico was passed and came into effect on 6th January, 2009.

  1. Efectos hematológicos inducidos por los programas de hipoxia intermitente

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    Domingo J. Ramos Campo

    2013-01-01

    Full Text Available Entre las estrategias de entrenamiento en condicio- nes de altitud simulada más utilizadas destaca la expo- sición a hipoxia intermitente ( IHE , la cual se aplica me- diante la estancia pasiva en habitaciones con ambiente hipóxico o a través de la respiración de aire con menos concentración de O 2 , junto con el método denomina- do entrenamiento en hipoxia intermitente ( IHT , que consiste en llevar a cabo sesiones de entrenamiento en condiciones de hipoxia (Millet, Roels, Schmitt, Woorons & Richalet, 2010. Los efectos de los programas de exposición y entre- namiento en hipoxia intermitente se relacionan con un incremento de la eritropoyesis que deriva en una mejora de parámetros fisiológicos relacionados con el rendimiento, como el umbral anaeróbico o el consumo máximo de oxígeno y un incremento del rendimiento anaeróbico. Tal como observamos en la literatura, los programas IHT parecen ser mucho más beneficiosos que los de IHE para estimular la eritropoyesis e incrementar el rendi- miento deportivo, si bien con ambos métodos se obser- va una mejora en los valores sanguíneos claves para la neoformación de glóbulos rojos y que afectan al ren- dimiento deportivo. Fundamentalmente esto se debe a que el ejercicio en hipoxia juega un rol importante en las adaptaciones hematológicas y fisiológicas del orga- nismo, si bien en este campo de investigación aún hay preguntas básicas que deben ser contestadas (Hoppeler & Vogt, 2001.

  2. Inducción de defectos de agrietamiento por hidrógeno a alta temperatura para la fabricación de patrones de calibración para ultrasonidos TOFD

    OpenAIRE

    Álvarez Cueva, Jesús Ángel

    2016-01-01

    Las probetas para ensayo se han fabricado por soldeo en la planta piloto de Fundación ITMA, reproduciendo así las condiciones de fabricación con parámetros de soldeo típicos de los fabricantes de recipientes a presión. Los defectos por HTHA se han inducido en el reactor de hidrógeno de Disbonding del ITMA, con parámetros operativos de carga de hidrógeno a alta presión parcial y alta temperatura. Finalmente sobre las probetas con defectos inducidos por HTHA, se ha realizado una evaluación meta...

  3. Papel del receptor alpha actitivado por proliferadores de peroxisoma en la fisiopatología del sistema cardiovascular

    OpenAIRE

    José Illnait-Ferrer

    2014-01-01

    Los receptores activados por proleferadores de peroxisomas del inglés (PPARs) pertenecen a una superfamilia de receptores que funcionan como factores de transcripción que regulan la función de los genes y que mediante la formación de peroxisomas, intervienen en importantes procesos tales como la diferenciación celular, la organogénesis, el metabolismo de carbohidratos, lípidos, proteínas y en la tumorigénesis. El PPARα se expresa principalmente en órganos y tejidos donde es muy importante el ...

  4. O exercício físico atenua o déficit autonômico cardíaco induzido pelo bloqueio da síntese do óxido nítrico El ejercicio físico atenúa el déficit autonómico cardiaco inducido por el bloqueo de la síntesis de óxido nítrico Physical exercise attenuates the cardiac autonomic deficit induced by nitric oxide synthesis blockade

    Directory of Open Access Journals (Sweden)

    Bruno Rafael Orsini Rossi

    2009-01-01

    íntesis del NO sobre el control autonómico cardiovascular en ratones sometidos al ejercicio aerobio durante diez semanas. MÉTODOS: Se dividieron ratones wistar en cuatro grupos: control tratados con ración y agua ad libitum durante diez semanas (RC; control tratados con NG-nitro-L-arginina metil éster (L-NAME en la última semana (RCL; entrenados durante diez semanas en cinta motorizada (RT; entrenados por diez semanas y tratados con L-NAME en la última semana (RTL. Se investigó el control autonómico cardiovascular en todos los grupos con la utilización de doble bloqueo con metilatropina y propranolol, y análisis de la variabilidad. RESULTADOS: Los grupos RCL y RTL presentaron hipertensión. El grupo RCL presentó taquicardia y predominio del tono simpático en la determinación de la FC tras el bloqueo autonómico farmacológico. El grupo RT presentó bradicardia y menor frecuencia cardiaca (FC intrínseca en relación a los demás. La evaluación de la variabilidad de la FC mostró menores valores absolutos y normalizados en la banda de baja frecuencia (BF en el grupo RCL. El grupo RTL presentó elevación en la banda de BF en valores absolutos. El análisis de la variabilidad de la PAS mostró que los grupos RCL y RTL presentaron mayores valores en la banda de BF. CONCLUSIÓN: El ejercicio físico previo impidió el déficit en el control autonómico cardiaco inducido por el tratamiento con L-NAME, pero no impidió el aumento en la variabilidad de la PAS.BACKGROUND: The nitric oxide (NO synthesis blockade is characterized by an increase in the cardiac sympathetic activity and the physical training promotes the decrease in the sympathetic activity. OBJECTIVE: We investigated the effect of the NO synthesis blockade on the autonomic cardiovascular control in rats submitted to aerobic exercises during a 10-week period. METHODS: Male Wistar rats were divided in four groups: control rats, treated with chow food and water ad libitum for 10 weeks (CR; control rats

  5. Creencias en torno al aborto inducido en un hospital público

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    Cruz García Lirios

    2013-06-01

    Full Text Available Objetivo: Establecer las propiedades psicométricas de un instrumento que pondera las creencias en torno al aborto inducido. Método: Se llevó a cabo un estudio correlacional y transversal con una muestra no probabilística de 120 derechohabientes de un hospital público ubicado en una entidad del centro de país. Materiales: Se construyó una Escala de Creencias en torno al Aborto Inducido la cual incluyó 17 reactivos con dos opciones de respuesta: falso o verdadero. Resultados: Para establecer la confiabilidad se estimó una curtosis multivariable de -2,578unaalfade0,73 y esfericidad de 0,832 con adecuación significativa. Se estableció un modelo estructural reflectivo (X² = 16,25; 11gl; p = 0,055; GFI = 0,975; RMR = 0,008 que se ajustó al modelo de medición (GFI = 0,90; RMR = 0,01. Discusión: Se recomienda la inclusión de otras variables tales como religión, usos y costumbres locales para explicar posibles modelos regionales de prácticas abortivas inducidas legalmente.

  6. Papel del receptor alpha actitivado por proliferadores de peroxisoma en la fisiopatología del sistema cardiovascular

    Directory of Open Access Journals (Sweden)

    José Illnait-Ferrer

    2014-01-01

    Full Text Available Los receptores activados por proleferadores de peroxisomas del inglés (PPARs pertenecen a una superfamilia de receptores que funcionan como factores de transcripción que regulan la función de los genes y que mediante la formación de peroxisomas, intervienen en importantes procesos tales como la diferenciación celular, la organogénesis, el metabolismo de carbohidratos, lípidos, proteínas y en la tumorigénesis. El PPARα se expresa principalmente en órganos y tejidos donde es muy importante el catabolismo de ácidos grasos y de glucosa para la producción de energía como el hígado y los músculos. El participa PPARα en la regulación de los procesos inflamatorios, de oxidación-reduccion en la angiogénesis, el metabolismo energético del músculo cardiaco, del hígado y los vasos sanguíneos, los son la base para el desarrollo de algunas enfermedades crónicas no transmisibles como la diabetes y la aterosclerosis. Tomando en consideración la importancia que el PPARα tiene el metabolismo de lípidos y carbohidratos, así como en algunos aspectos de la fisiopatología y farmacología del sistema cardiovascular, el propósito de esta breve reseña bibliográfica es hacer un análisis de los aspectos más sobresalientes del papel del PPARα en la fisiopatología de este sistema, ya que, a pesar de los significativos avances en el manejo terapéutico de las enfermedades cardiovasculares, estas se encuentran entre las primeras causas de mortalidad en todo el mundo. Aún existen algunos aspectos en relación con el papel del PPARα que requieren de mayor profundización y estudio, pero sin duda el tema ofrece una perspectiva interesante en la investigación de su utilidad como objetivo terapéutico de diversas alteraciones metabólicas relacionadas con enfermedades de elevada frecuencia.

  7. El aborto inducido. Una visión histórica de su manejo.

    Directory of Open Access Journals (Sweden)

    Manuel Antonio Artuz

    2009-11-01

    Full Text Available El aborto inducido es un problema de interés para la salud pública mundial, tanto en los países donde las leyes lo permiten como en aquellos donde el procedimiento se practica en forma clandestina. El presente artículo es el resultado de una revisión bibliográfica de los métodos más comúnmente empleados en la inducción del aborto en los últimos 50 años, comparándolos con los métodos utilizados en la actualidad, analizando sus riesgos y complicaciones a corto y largo plazo y tratando de sistematizar y actualizar el conocimiento que se tiene al respecto.

  8. Profilaxia do prurido causado pela administração subaracnóidea de sufentanil: efeitos do droperidol, da nalbufina, do ondansetron e da combinação deles Profilaxis del prurito inducido por la administración subaracnoidea de sufentanil: influencia do droperidol, da nalbufina, do ondansetron y da combinacion de elles Prevention of itching after spinal sufentanil: effects of droperidol, nalbuphine, ondansetron and the association of them

    Directory of Open Access Journals (Sweden)

    André Kolm

    2006-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O uso espinhal de opióides pode causar alguns efeitos indesejáveis, dentre os quais, o mais freqüente é o prurido que, apesar de sua baixa morbidade, pode proporcionar desconforto intenso ao paciente e prolongar o período de internação. O objetivo deste estudo foi avaliar diversas opções terapêuticas no tratamento profilático do prurido após administração de sufentanil por via subaracnóidea. MÉTODO: Foram distribuídos de maneira aleatória, por sorteio, 100 pacientes a serem submetidos à intervenção cirúrgica não-obstétricas em cinco grupos, de acordo com o tratamento utilizado: controle (ausência de tratamento - C; droperidol 2,5 mg (D; nalbufina 10 mg (N; associação dos medicamentos anteriores (DN e ondansetron 8 mg (O. O prurido foi avaliado quantitativamente 30 minutos, 1, 2, e 3 horas após a administração subaracnóidea de sufentanil. RESULTADOS: Os grupos C e O apresentaram incidência significativamente maior de prurido em relação aos grupos D, N e DN. Entretanto, não houve diferença significativa na necessidade de tratamento específico com naloxona entre os grupos tratados. CONCLUSÕES: O tratamento profilático do prurido neste estudo, independentemente do fármaco utilizado, diminuiu sua intensidade e limitou a necessidade de tratamento específico com naloxona.JUSTIFICATIVA Y OBJETIVOS: El uso espinal de opioides puede ser causa de efectos indeseables, entre los que el prurito es el más frecuente y a pesar de su escasa morbilidad puede ser causa de intenso desconfort y prolongar el tiempo de internación. El objetivo de este estudio es evaluar diferentes opciones terapéuticas para la prevención del prurito que ocurre después de la administración subaracnoidea de sufentanil. MÉTODO: Cien pacientes que iban a recibir cirugías no obstétricas fueron divididos aleatoriamente (sorteo en 5 grupos de acuerdo al tratamiento preventivo usado: control (sin tratamiento, grupo C

  9. Efeito do sulfato de vanadil sobre o comprometimento metabólico muscular induzido pela imobilização de membro posterior de ratos Efecto del sulfato de vanadil sobre comprometimiento metabólico muscular inducido por la inmovilización del miembro posterior en ratones Effect of the vanadyl sulphate on the muscular metabolic compromising induced by immobilization of posterior limb of rats

    Directory of Open Access Journals (Sweden)

    Gabriel Borges Delfino

    2006-12-01

    Full Text Available A proposta deste trabalho foi avaliar o efeito do sulfato de vanadil (SV no perfil metabólico muscular de membro posterior imobilizado de ratos. Ratos Wistar foram divididos nos grupos (n = 6: controle (C, imobilizado em posição neutra do tornozelo (I, tratado com sulfato de vanadil (SV, 0,25mM, VO e imobilizado tratado com SV (I + SV durante sete dias. Após o período experimental, foram avaliadas as reservas de glicogênio (RG dos músculos sóleo (S, gastrocnêmio branco (GB e vermelho (GV, tibial anterior (TA e extensor longo dos dedos (ELD, além do peso do S e ELD. A análise estatística foi realizada pela ANOVA seguida pelo teste de Tukey (p La propuesta de este trabajo ha sido la de evaluar el efecto del sulfato de vanadil (SV en el perfil metabólico muscular de miembro posterior inmovilizado de ratones. Ratones Wistar fueron divididos en grupos (n = 6: control (C, inmovilizado en posición neutra de tobillo (I, tratado con sulfato de vanadil (SV, 0,25mM, VO e inmovilizado tratado con SV (I + SV durante 7 días. Después del periodo experimental, fueron evaluadas las reservas de glicógeno (RG de los músculos soleo (S, gastrocnemio blanco (GB y colorado (GV, tibial anterior (TA y extensor largo de los dedos (ELD, además del peso de S y ELD. El análisis estadístico fue realizado por ANOVA seguido del test de Tukey (p The purpose of this study was to evaluate the metabolic performance of immobilized skeletal muscle in rats treated with vanadyl sulphate. Male Wistar rats were divided in groups (n = 6: control (C, immobilized (I, treated with vanadyl sulphate (VS, 0,25 mM and immobilized treated with vanadyl sulphate (I + VS during seven days. The concentration of vanadyl sulphate diluted in water was 0,25 mM. After experimental stage, the glycogen content (GC was evaluated in soleus (S, white gastrocnemius (WG, red gastrocnemius (RG, tibialis anterior (TA and extensor digitorum longus (EDL muscles, besides S and EDL weight. The

  10. Concentration of Radon Progeny in Air by Alpha Spectrometry Measurement; Medida de los descendientes del radon en aire por Espectrometria Alfa

    Energy Technology Data Exchange (ETDEWEB)

    Acena, M. L.; Crespo, M. T.

    1989-07-01

    The concentration of radon progeny in air has been determined by alpha spectrometry measurement of 214 Po and 318 Po. A known volume of air was passed through a filter, then the alpha activity was directly measured on this filter. (Author) 15 refs.

  11. Degradation of polyethylene induced by plasma in oxidizing atmospheres; Degradacion de polietileno inducido por plasma en atmosferas oxidantes

    Energy Technology Data Exchange (ETDEWEB)

    Colin, E.; Olayo, M.G.; Cruz, G.J. [Facultad de Quimica, UAEM, Av. Tollocan y Colon, 50000 Toluca (Mexico)

    2002-07-01

    The garbage of polyethylene is not easily degradable in normal environmental conditions . The indiscriminate use of this polymer and the enormous quantity of garbage which is generated carries a damage to the environment due to its long life as waste. The objective of this work is to study the conditions in which can be carried out the degradation of polyethylene. A form of accelerating the degradation is exposing it to plasma with reactive atmospheres. In this work a study of surface modification of polyethylene by plasmas with discharges of direct current of oxygen and nitrogen is presented. (Author)

  12. Changes in the chromogene properties of the betalaine; Cambios en las propiedades cromogenas de las betalainas inducidos por radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez N, S.; Pinedo S, A.; Amador V, P.; Chacon R, A.; Arcos P, A.; Vega C, H.R. [Unidad Academica de Ciencias Nucleares, C. Cipres 10, Fracc. La Penuela, 98068, Zacatecas, Zac. (Mexico)

    2005-07-01

    The changes of coloration of four natural extracts were determined in function of the absorbed dose taken place by a source of rays gamma of Cs-137. The used natural extracts contain betalaine that are natural pigments of some plants as the beet root, of there their name. They are also in abundant form in the fruits (tunas) of some species of the Opuntia gender. The extracts were obtained by maceration, starting from beet root and three tuna varieties, and they were stabilized to pH 5.5 the change of coloration you determines in a spectrophotometer ultraviolet/visible by means of the absorbance from the samples to photons of 475, 535 and 600 nm of wave longitude. The absorbance was measured, to different intervals of time. The relationship settled down between the absorbed dose and the chromogene properties of the pigment, with the intention of using it as possible dosemeter. (Author)

  13. Cambios inducidos por el aprendizaje en el sistema motor de las vibrisas de ratón

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    José María Delgado García

    2005-03-01

    Full Text Available Aunque se sabe que la corteza motora primaria comanda movimientos corporales, aún no se conoce con precisión cómo ejerce este control. En este trabajo se estudió la participación de la corteza motora primaria durante el aprendizaje motor en el sistema sensitivo-motor de las vibrisas en ratones

  14. Estudio de los procesos celulares inducidos por campos eléctricos en sistemas Lab-on-a-Chip

    OpenAIRE

    Oliva Brañas, Ana María

    2014-01-01

    En esta tesis doctoral se ha estudiado de forma sistemática la relación entre los campos eléctricos y las células, y los efectos que éstos tienen a diferentes niveles (supervivencia, metabolismo, expresión proteica, morfología), en dispositivos de tipo Lab-on-a-Chip y aplicándolo a un caso concreto de un concentrador basado en dielectroforesis. Se ha realizado de manera que se ha podido diferenciar la aportación de cada uno de los parámetros eléctricos a los cambios. Se ha diseñado, fabr...

  15. Semi-preparative separation of {alpha} and {beta}-amyrin by high performance liquid chromatographic; Separacao semipreparativa de {alpha} e {beta}-amirina por cromatografia liquida de alta eficiencia

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Marluce Oliveira; Hamerski, Lidilhone; Pinto, Angelo C., E-mail: hamerski_1@hotmail.co [Universidade Federal do Rio de Janeiro (IQ/UFRJ), RJ (Brazil). Inst. de Quimica

    2011-07-01

    The resin obtained from species of the genus Protium (Burseraceae) is formed mostly of pentacyclic triterpenes: {alpha}-amyrin and {beta}-amyrin. The separation and purification of these triterpenes were optimized in three steps. (author)

  16. toxicidad neuroendocrina inducida por cadmio

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    A Romero

    2008-01-01

    Full Text Available El cadmio es un agente químico tóxico importante debido a su creciente nivel en el medio ambiente como resultado de prácticas industriales y agrícolas. Como perturbador endocrino, el cadmio modifica la secreción de hormonas hipofisarias. Los efectos indirectos del cadmio provocan la generación de especies reactivas de oxígeno y reducen la actividad de las proteínas implicadas en las defensas antioxidantes. La melatonina es conocida como un potente antioxidante, scavenger de radicales libres y quelante de metales sintetizada en la glándula pineal. De esta manera, las acciones antioxidantes de esta indolamina protegen frente a la peroxidación lipídica y el daño oxidativo de los radicales y de sus productos tóxicos. Los trabajos recopilados en esta revisión ponen de manifiesto la capacidad antioxidante de la melatonina y, por lo tanto, su posible papel protector frente a la toxicidad del cadmio en lo que se refiere al estrés oxidativo y peroxidación lipídica inducidos por la exposición a este metal.

  17. Ocular changes due to systemic alpha-interferon therapy for hepatitis C Alterações oculares por uso sistêmico de alfa-interferon em pacientes com hepatite C

    Directory of Open Access Journals (Sweden)

    Liang Shih Jung

    2004-12-01

    Full Text Available PURPOSE: To describe ocular (specially fundoscopic changes due to systemic alpha-interferon (IFN therapy in patients with hepatitis C. This is a prospective, descriptive and observational (non-interventional study, and its results are preliminary. METHODS: Patients were selected with indication of alpha-interferon therapy for hepatitis C. They underwent ocular examinations before therapy and 1, 3, 6 and 12 months after starting the therapy. HIV patients and those who had a history of previous treatment with alpha-interferon were excluded from the study, but examined. RESULTS: Fifty-one patients were selected from November 1999 to June 2000. The male-to-female ratio was 1.55. The age average was 47 years. The best corrected visual acuity ranged from 20/15 to 20/40. Most of the symptomatic patients complained of foreign body sensation in the eyes, which became more tolerable with time. Complaints comprised flu-like symptoms, joint pain, depression, headache, and general weakness. Ocular findings related to alpha-interferon were: cotton wool spots (3 eyes and intraretinal hemorrhage (1 eye. One patient died during the study, due to another disease not related to hepatitis, and one patient refused to be examined. CONCLUSIONS: There are retinal vascular changes due to systemic alpha-interferon for hepatitis C. There are no studies in our country describing ocular changes in patients with hepatitis C on therapy with alpha-interferon. General physicians and specially gastroenterologists should pay special attention to this problem, and refer these patients to the ophthalmologist in order to determine and follow any lesion that may be related to the use of this drug.OBJETIVO: Avaliar alterações oculares (em especial lesões fundoscópicas em pacientes com hepatite C tratados com alfa-interferon (IFN. MÉTODOS: Estudo prospectivo, descritivo e observacional de pacientes com hepatite C do serviço de Gastroenterologia da UNIFESP com indicações de uso

  18. Respuesta de las neuronas sensitivas al estrés genotóxico inducido por radiaciones ionizantes y por la inhibición del proteasoma

    OpenAIRE

    Palanca Cuñado, Ana Rosa

    2014-01-01

    RESUMEN: Las neuronas son muy vulnerables al estrés genotóxico. Esta vulnerabilidad es particularmente relevante en las neuronas ganglionares sensitivas (NGS) dado que los ganglios carecen de barrera hematoencefálica que impida el acceso de agentes genotóxicos, como determinados fármacos utilizados en la quimioterapia del cáncer. Tales agentes producen un efecto neurotóxico que se traduce en neuropatías periféricas. Nuestro estudio analiza las bases celulares de la neurotoxicidad en las NGS e...

  19. Não vou esquecer nunca!: a experiência feminina com o abortamento induzido "No lo olvidaré nunca!": la experiencia femenina en el aborto inducido "I'll never forget it!": women's experience with induced abortion

    Directory of Open Access Journals (Sweden)

    Ivanilda Lacerda Pedrosa

    2000-12-01

    Full Text Available Utilizando a abordagem do Interacionismo Simbólico, objetivamos verificar os significados atribuídos ao abortamento induzido por mulheres que adotaram essa conduta e analisar seu impacto sobre o autoconceito dessas mulheres. Nos resultados, evidenciamos a contraditoriedade dos discursos das mulheres ao avaliar a experiência, e as reações emocionais que relataram, tais como remorso/consciência pesada, arrependimento, sensação de perda e, principalmente, culpa que, segundo suas narrativas, carregariam para o resto de suas vidas.Teniendo como base el abordaje del Interaccionismo Simbólico, se pretendió averiguar cuales los significados atribuidos al aborto inducido por mujeres que optaron por esa conducta y analizar el impacto de dicha experiencia en su autoconcepto. En los resultados obtenidos se destacan la contradicción de sus discursos al evaluar la experiencia, y las reacciones emocionales que habían desarrollado, dentro de las cuales fueron relatadas remordimiento/conciencia pesada, arrepentimiento, sensación de perdida y principalmente, la culpabilidad que según sus relatos, llevarían para toda la vida.Based on the symbolic interactionist approach, we aimed to verify the meanings attributed to induced abortion by women who adopted such behavior as well as to analyze the impact of the experience on their self-image. The results point out the contradiction in women's discourse when they evaluate the experience, and the emotional negative reactions they had developed: remorse/guilty conscience, regret, feeling of grief, and mainly guilt, which, according to their accounts, they will carry for the rest of their lives.

  20. Vigilancia ocupacional del trabajador expuesto a alteraciones de la salud inducidas por ruido

    Directory of Open Access Journals (Sweden)

    Julio C. Guerrero Pupo

    2005-01-01

    Full Text Available Aborda un estudio donde se analiza que la sustentabilidad terrícola está en peligro por los problemas ambientales presentes, destacando, a nivel local el ruido. Señala que es "causa" de alteraciones a la salud en ciertos puestos de trabajo y que el proceso se puede esquematizar como un eje constituido por factor de riesgo-exposición -efecto. Argumenta que empleó el método epidemiológico. Plantea la vigilancia epidemiológica hombre - ambiente y los efectos auditivos y no auditivos inducidos por ruido. Concluye que el Estado anhela su control y que su mejor representante es el médico de la familia al formarse integralmente en varias disciplinas.

  1. Coefficient Alpha

    OpenAIRE

    Panayiotis Panayides

    2013-01-01

    Heavy reliance on Cronbach’s alpha has been standard practice in many validation studies. However, there seem to be two misconceptions about the interpretation of alpha. First, alpha is mistakenly considered as an indication of unidimensionality and second, that the higher the value of alpha the better. The aim of this study is to clarify these misconceptions with the use of real data from the educational setting. Results showed that high alpha values can be obtained in multidimensional scale...

  2. Neuroprotecci??n mediada por diterpenos aislados de Sideritis spp. frente al estr??s oxidativo en astrocitos

    OpenAIRE

    Gonz??lez-Burgos, E.; Palomino, O.M.; Carretero Accame, M.E.; G??mez-Serranillos, M.P.

    2010-01-01

    La presente investigaci??n aborda el estudio de las propiedades neuroprotectoras, en base a la capacidad antioxidante, de los diterpenos andalusol, conchitriol y sidol aislados de diferentes especies del g??nero Sideritis. La actividad protectora de estos compuestos fue evaluada en un modelo de estr??s oxidativo inducido por el per??xido de hidr??geno sobre la l??nea celular U373 MG de astrocitoma humano. Los resultados mostraron que un pretratamiento durante 24 horas con los dite...

  3. Diferencias en el número de cesáreas en los partos que comienzan espontáneamente y en los inducidos

    Directory of Open Access Journals (Sweden)

    Antonio Hernández Martínez

    2014-01-01

    Full Text Available Fundamentos: La inducción del parto (IDP puede estar asociada a mayores complicaciones para la mujer gestante. El objetivo de este trabajo fue determinar las diferencias en el número de cesáreas entre partos espontáneos y partos inducidos. Métodos: Cohortes históricas sobre un total de 841 inducciones y 2.534 partos espontáneos realizados entre 2009 y 2011 en el Hospital "Mancha-Centro" de Alcázar de San Juan. Se empleó análisis multivariante por medio de regresión logística binaria para control de la confusión. Resultados: La prevalencia de IDP fue del 22,9%, presentándose como indicaciones más frecuentes la rotura prematura de membranas (RPM de más de 12 horas (22,7% y diabetes mellitus mal controlada con un 22,5%. Se observó relación entre inducción y riesgo de cesárea tanto en mujeres nulíparas (OR= 2,68; Intervalo de confianza [IC] 95%: 2,15-3,34 como en multíparas (OR=2,10; [IC] 95%:1,72-2,57. La indicación con mayor riesgo de cesárea fue la gestación cronológicamente prolongada (GCP (37,1% seguida del registro cardiotográfico (RCTG patológico (35,3% y estados hipertensivos del embarazo (EHE (4,0%. La IDP también se relacionó con la mayor duración de la dilatación (OR=6,00; IC 95%:4,02-8,95, empleo de epidural (OR=3,10;IC95%: 2,24-4,29 y necesidades de transfusión sanguínea (OR=3,33; IC 95%:1,70-9,67. Conclusiones: La IDP es un factor de riesgo para una mayor duración de la dilatación, empleo de analgesia epidural, necesidad de transfusión sanguínea y de cesárea tanto en mujeres nulíparas como en multíparas, especialmente en las indicaciones de gestación cronológicamente prolongada, registro cardiotocográfico patológico y estados hipertensivos del embarazo. No se encontró relación con la duración del período expulsivo, la práctica de episiotomía, desgarros, sangrado excesivo y rotura uterina.

  4. CIRUGÍA DE CATARATA POR MICROINCISIONES BIMANUALES Y COAXIALES

    Directory of Open Access Journals (Sweden)

    Juan Raúl Hernández Silva

    2012-03-01

    Full Text Available Objetivo: Comparar los resultados de la cirugía de catarata por las técnicas de microincisiones coaxiales y microincisiones bimanuales en el Instituto Cubano de Oftalmología “Ramón Pando Ferrer” en el período de junio de 2009 a junio de 2011. Métodos: Los pacientes fueron diagnosticados con catarata senil o presenil. De estos, 41 pacientes se operaron con la técnica de microincisiones coaxiales y 27 pacientes con la técnica de microincisiones bimanuales. Se determinó: edad, dureza del cristalino, agudeza visual mejor corregida y sin corrección preoperatoria y postoperatoria, media del astigmatismo inducido, pérdida celular endotelial, tiempo efectivo de ultrasonido y el equivalente esférico. Resultados: La mayoría de los pacientes tenían edades superiores a 50 años. Se empleó un tiempo efectivo de ultrasonido menor a un minuto para emulsificar el cristalino cataratoso, los cuales tenían una dureza para ambas técnicas ON3. El equivalente esférico se encontró según lo planificado en el preoperatorio para la emetropía. En el postoperatorio se obtuvo una corrección significativa del cilindro queratométrico y refractivo. Mejoró en su totalidad para ambas técnicas quirúrgicas, la mejor agudeza visual con corrección.  La media del astigmatismo inducido fue menor a 0,5 dioptrías, con una pérdida celular endotelial menor a un 5 %  en ambos grupos. Conclusiones: Para ambas técnicas quirúrgicas se logró resultados satisfactorios que demuestran la efectividad de las mismas.

  5. El aumento del sodio intracelular inducido por la eliminación de calcio externo regula la movilidad del espermatozoide humano /

    OpenAIRE

    Torres Flores, Víctor Manuel

    2011-01-01

     tesis que para obtener el grado de Doctor en Ciencias Biológicas, presenta Víctor Manuel Torres Flores ; asesor Alberto Darszon Israel, Luis Manuel Montaño Ramírez, Juan Arcadio Molina Guarneros. 79 páginas : ilustraciones. Doctorado en Ciencias Biológicas UNAM, Facultad de Ciencias, 2011

  6. Estudio de los mecanismos del estrés replicativo inducido por la inhibición de la mavalonato difosfato descarboxilasa

    OpenAIRE

    Martín Sánchez, Covadonga

    2012-01-01

    Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 13-07-2012 El requerimiento de colesterol para la proliferación de las células de mamíferos está bien establecido. En nuestro laboratorio se había demostrado que el colesterol era nec esario para la correcta transición de la fase G2 a M en el ciclo celular y para la citocinesis. Cuando se tratan con altas dosis de estatinas, inhibidores ...

  7. Changes in the chromogen properties of the betalaine induced by gamma radiation; Cambios en las propiedades cromogenas de las betalainas inducidos por radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez N, S.; Pinedo S, A.; Amador V, P.; Chacon R, A.; Arcos P, A.; Vega C, H.R. [Unidad Academica de Ciencias Nucleares, C. Cipres 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2005-07-01

    The changes of coloration of four natural extracts in function of the absorbed dose produced by a gamma rays source of {sup 137} Cs were determined. The natural extracts used contain betalaines that are natural pigments of some plants as the beet about that their name. They are also in abundant form in the fruits (tunas) of some species of the Opuntia genus. The extracts were obtained by maceration, starting from beet and three tuna varieties, and they were stabilized to pH 5.5 The change of coloration it was determined in a visible ultraviolet spectrophotometer by means of the absorbance from the samples to photons of 475, 535 and 600 nm of wavelength. The absorbance to different intervals of time was measured. The relationship between the absorbed dose and the chromogene properties of the pigment, with the intention of using it as possible dosemeter was settled down. (Author)

  8. Obtention of zinc polymethacrylate via free radicals induced by gamma radiation; Obtencion del polimetacrilato de zinc via radicales libres inducidos por radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Urena N, F.; Flores E, J. [Departamento de Fisica, Instituto Nacional de Investigaciones Nucleares, C.P. 52045 Estado de Mexico (Mexico)

    2000-07-01

    The objective of this work was to synthesise the monomer of zinc methacrylate and subsequently to carry out the polymerization reaction with the purpose to obtain the compound desired, the zinc polymethacrylate. For this it was used a gamma radiation source, {sup 60} Co, as initiator of the polymerization reaction. (Author)

  9. Anti mutagenesis of chemical modulators against damage induced by reactor thermal neutrons; Antimutagenesis de moduladores quimicos contra el dano inducido por neutrones termicos de reactor

    Energy Technology Data Exchange (ETDEWEB)

    Zambrano A, F.; Guzman R, J.; Garcia B, A.; Paredes G, L.; Delfin L, A. [Instituto Nacional de Investigaciones Nucleares, Departamentos de Materiales Radiactivos, de Biologia, del Reactor y Gerencia de Aplicaciones Nucleares en la Salud, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1999-07-01

    The mutations are changes in the genetic information whether for spontaneous form or induced by the exposure of the genetic material to certain agents, called mutagens: chemical or physical (diverse types of radiations). As well as exist a great variety of mutagens and pro mutagens (these last are agents which transform themselves in mutagens after the metabolic activation). Also several chemical compounds exist which are called antimutagens because they reduce the mutagens effect. The C vitamin or ascorbic acid (A A) presents antimutagenic and anti carcinogenic properties. On the other hand a sodium/copper salt derived from chlorophyll belonging to the porphyrin group (C L) contains a chelated metal ion in the center of molecule. It is also an antioxidant, antimutagenic and anti carcinogenic compound, it is called chlorophyllin. The objective of this work is to establish if the A A or the C L will reduce the damages induced by thermal and fast reactor neutrons. (Author)

  10. Efectos de la quercetina sobre las alteraciones en el comportamiento y estrés oxidativo inducidos por rayos X en ratas

    OpenAIRE

    Marina Hernández, Raquel

    2013-01-01

    271 p. El trabajo es un estudio in vivo del efecto radiomodificador de la quercetina para contribuir a definir su potencial aplicación a la radioterapia, incluyendo como variable a considerar el intervalo de tiempo transcurrido desde la administración de radiación. Debido a los efectos deletéreos de la radiación ionizante sobre el sistema nervioso y el hígado, entre otros, es interesante llevar a cabo estudios sobre el efecto radiomodificador relativos al comportamiento y la fisiología en...

  11. Inhibitory action of chlorophyllin of autosome recessive lethals induced by irradiation; Accion inhibidora de la clorofilina de letales recesivos autosonicos inducidos por irradiacion

    Energy Technology Data Exchange (ETDEWEB)

    Salceda, V.M.; Pimentel, P.A.E.; Cruces, M.P. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: vmss@nuclear.inin.mx

    2006-07-01

    The chlorolin is a sodium salt of the chlorophyll that has a strong protective action of the damage induced by different agents so much physical as chemical. In Drosophila there is reported this effect in somatic cells. In contrast, in germinal cells using tests with the sexual chromosomes has not been found such inhibitory action. For this reason, in this occasion we will refer to the effect of the lethality induced in autosome chromosomes, in particular to the chromosome II of this species. For such effect groups of males of the line Canton-S its were pre-treated for 24h with or without 69 mm of CCS and later on treaties with or without 40 Gy of gamma irradiation. The males were then subjected to the technical Cy L / Pm for the detection of recessive lethals. In the third generation the respective counts of the descendant of each one of them to determine the corresponding categories for each extracted chromosome were made. To be mendelian crosses it is expected for a normal chromosome a proportion 2:1 of individuals with genotype Cy L / +: +/+. The absence of individuals +/+ it is indicative of a lethal gene, until 10% of these individuals of each male's total descendant, it is considered that is carrying of a semi lethal gene. The sum of lethal and semi lethals constitutes the category detrimental. The obtained results indicated that the pre-treatment with CCS reduces in a significant way the frequency of induced lethals by 40 Gy of gamma rays. The fact that an effect inhibitor has not been observed in the test of recessive lethal bound to the sex obtained previously, it contrasts with the effect observed in the chromosome II, results of this study and with the one observed in the chromosome III in somatic cells. The above-mentioned shows a differential action of the CCS between sexual chromosomes and autosomal before the effect of the gamma radiation. At the moment we don't have an explanation to these evidences. To evaluate the action of the chlorophyllin on the damage caused by the radiation, it was into accothe presence of lethal and semi lethals autosomal. One observes this way that even without the use of the radiation the semi lethals frequency is diminished when the chlorophyllin is applied, in this case the decrease was significant and although there was decrease in the case of the irradiated group this it was not significant; in the case of the lethal ones it happened the opposite it was not significant in radiation absence on the contrary elevate the frequency of this type of genes, however, before the radiation and with pre-treatment with chlorophyllin this it reduced the frequency of autosomal recessive lethals significantly. This is important because in the case of bound recessive lethals recessive to the sex this doesn't happen. (Author)

  12. Evaluation of defects induced by neutron radiation in reactor pressure vessels steels; Evaluacion de los defectos inducidos por la radiacion neutronica en los aceros de vasijas

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Jimenez, J.

    1978-07-01

    We have developed a method for calculating the production of neutron induced defects (depleted zone and crowdions) in ferritic pressure vessel steels for different neutron spectra. They have been analysed both the recoil primary atoms produced by elastic and inelastic collisions with fast neutrons and the ones produced by gamma-ray emission by thermal neutron absorption. Theoretical modelling of increasing in the ductile-brittle transition temperature of ferritic steels has been correlated with experimental data at irradiation temperature up to 400 degree centigree (Author) 15 refs.

  13. Evaluación de parámetros citogenéticos inducidos por extractos acuosos de siete plantas usadas como agentes antihipertensivos en medicina popular argentina

    OpenAIRE

    Amat, Anibal Gumersindo; Yajia, Marta Esther; González, Claudio F.; Lorca, Graciela L.; Sánchez Gonzalez, Felipa; Riglos, Ana G.; Verón, José R.

    2002-01-01

    Han sido estudiados los extractos acouosos de siete especies utilizadas en el NE de Argentina para el tratamiento de la hipertensión, con el propósito de evaluar su acción sobre la mitosis como indicador de presunción de actividad antimitótica o genotóxica, usando el test de Allium cepa. Los resultados mostraron una disminución del índice mitótico en todas las especies estudiadas, pero la acción antimitótica fue estadísticamente significativa sólo en el caso de los extractos de Aristolochi...

  14. Ca2+-ATPasa y Muerte Celular Inducida por Ca2+ en células Cardíacas H9c2

    OpenAIRE

    Lax Pérez, Antonio Manuel

    2009-01-01

    La Ca2+-ATPasa de RS puede hidrolizar ATP a través de una ruta alternativa en la que solo intervienen conformaciones de la proteína que no unen Ca2+. El mecanismo molecular de esta actividad hidrolítica implica un cambio conformacional inducido por ATP que produce aproximaciones de los dominios citosólicos. El uso de indicadores fluorescentes y compuestos que movilizan Ca2+ permite caracterizar flujos y depósitos intracelulares de Ca2+ que están implicados en la generación de señales intracel...

  15. Buffett's Alpha

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Kabiller, David; Heje Pedersen, Lasse

    Berkshire Hathaway has realized a Sharpe ratio of 0.76, higher than any other stock or mutual fund with a history of more than 30 years, and Berkshire has a significant alpha to traditional risk factors. However, we find that the alpha becomes insignificant when controlling for exposures to Betting...

  16. Alpha fetoprotein

    Science.gov (United States)

    Fetal alpha globulin; AFP ... Greater than normal levels of AFP may be due to: Cancer in testes , ovaries, biliary (liver secretion) tract, stomach, or pancreas Cirrhosis of the liver Liver cancer ...

  17. por valores

    Directory of Open Access Journals (Sweden)

    Jazmín Díaz-Barrios

    2005-01-01

    Full Text Available La era actual se caracteriza por una búsqueda de la identidad del hombre, donde el pivote del cambio organizacional es el individuo; cambiar en este entorno depende, en gran medida, de los valores que imperen en la cultura de la organización. Este trabajo documental intenta identificar aquellos valores, condición sine-qua-non, para el logro de los objetivos de cambio y analizarlos a fin de determinar sus indicadores, con el objeto de presentar una herramienta a las organizaciones que les facilite adaptarse a los nuevos tiempos. Se encontró que los valores: Delegación, Comunicación, Colaboración, Participación y Aprendizaje, son esenciales en los cambios integrales de esta era. Se determinaron 20 indicadores de su presencia. Se concluye que con esta información cada ente puede elaborar instrumentos que le permitan saber si los valores requeridos están presentes y en caso contrario tomar decisiones que alineen a la organización alrededor de los valores humanistas planteados, incrementando así las posibilidades de éxito en el proceso de cambio y por ende, las posibilidades de supervivencia en esta nueva época.

  18. Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats Efeito da acupuntura sobre a concentração de TNF-alfa, IL-1b e IL-10 no exsudato peritoneal de ratos com peritonite induzida por carragenina

    Directory of Open Access Journals (Sweden)

    Márcia Valéria Rizzo Scognamillo-Szabó

    2005-02-01

    Full Text Available Acupuncture is an ancient and empirical therapeutic procedure known by its efficacy in the treatment of pain. However, the influence of acupuncture on inflammatory process is still poorly understood and additional research is needed. In this work, we investigated the mechanism of action of manual acupuncture on the inhibition of neutrophil migration to the peritoneal cavity induced by the inflammatory stimulus carrageenan in Wistar rats. Previous results from our laboratory showed that this anti-inflammatory effect is not due to endogenous corticoid release. Furthermore, the concentration of IL-1b, but not of TNF-alpha or IL-10 in the carrageenan-induced exudates was reduced in the acupuncture group. Further research will be needed to elucidate the mechanisms involved in the anti-inflammatory action of acupuncture as described here.A acupuntura é método terapêutico milenar reconhecido por sua eficácia no tratamento da dor, porém seu efeito sobre processos inflamatórios é ainda pouco conhecido e maiores estudos são necessários. Neste trabalho, é investigado o mecanismo de ação da acupuntura manual sobre a inibição na migração de neutrófilos para a cavidade peritoneal induzida por carragenina em ratos Wistar. Resultados prévios indicam que esse efeito antiinflamatório não depende de hormônios corticóides. Entretanto, as concentrações de IL-1b no exsudato induzido por carragenina foram reduzidas pelo tratamento com acupuntura. Por outro lado os níveis de TNF-alfa e IL-10 não foram afetados pelo tratamento. Mais pesquisas poderão elucidar os mecanismos envolvidos na ação antiinflamatória da acupuntura.

  19. Rat hepatocyte invasion by Listeria monocytogenes and analysis of TNF-alpha role in apoptosis Invasão de hepatócitos de rato por Listeria monocytogenes e análise do papel do TNF-alfa na apoptose

    Directory of Open Access Journals (Sweden)

    Sânia Alves dos Santos

    2005-04-01

    Full Text Available Listeria monocytogenes, etiological agent of severe human foodborne infection, uses sophisticated mechanisms of entry into host cytoplasm and manipulation of the cellular cytoskeleton, resulting in cell death. The host cells and bacteria interaction may result in cytokine production as Tumor Necrosis Factor (TNF alpha. Hepatocytes have potential to produce pro-inflammatory cytokines as TNF-alpha when invaded by bacteria. In the present work we showed the behavior of hepatocytes invaded by L. monocytogenes by microscopic analysis, determination of TNF-alpha production by bioassay and analysis of the apoptosis through TUNEL technique. The presence of bacterium, in ratios that ranged from 5 to 50,000 bacteria per cell, induced the rupture of cellular monolayers. We observed the presence of internalized bacteria in the first hour of incubation by electronic microscopy. The levels of TNF-alpha increased from first hour of incubation to sixth hour, ranging from 0 to 3749 pg/mL. After seven and eight hours of incubation non-significant TNF-alpha levels decrease occurred, indicating possible saturation of cellular receptors. Thus, the quantity of TNF-alpha produced by hepatocytes was dependent of the incubation time, as well as of the proportion between bacteria and cells. The apoptosis rate increased in direct form with the incubation time (1 h to 8 + 24 h, ranging from 0 to 43%, as well as with the bacteria : cells ratio. These results show the ability of hepatocyte invasion by non-hemolytic L. monocytogenes, and the main consequences of this phenomenon were the release of TNF-alpha by hepatocytes and the induction of apoptosis. We speculate that hepatocytes use apoptosis induced by TNF-alpha for release bacteria to extracellular medium. This phenomenon may facilitate the bacteria destruction by the immune system.Listeria monocytogenes, agente etiológico de infecção grave de origem alimentar, utiliza mecanismos sofisticados de entrada no citoplasma

  20. Determination of total alpha and beta activity in water for human consumption by LSC(Liquid Scintillation Counter); Determinacao de atividades alfa e beta total em agua para consumo humano por LSC (Contador de Cintilacao Liquida))

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    The Ordinance Brazilian of Ministry of Health (MS 2914/2011) establishes the standards for quality of water intended for human consumption, being limits values of 5.0 Bq/L for gross alpha, and 1.0 Bq/L for gross beta radioactivity. The liquid scintillation spectrometry (LSC) technique has been presented as an alternative to conventional procedure using gas flow proportional counter. The present work shows a review of the methods for determination of gross alpha and gross beta in water by using LSC. Between the factors that influence the accuracy and repeatability of the analytical results we can highlight: thermal preconcentration, type of the acid and calibration standard. A procedure was established and carried out to samples of the National Program of Intercomparison of Radionuclides in Environmental Samples for evaluation of its performance. The gross alpha and gross beta analysis in samples of the public water supplies in the Metropolitan Region of Goiania, state of Goias was carried out. The results are consistent with the guideline values form the Ministry of Health concerning radioactivity. (author)

  1. Características clínicas y fármacos recibidos por los pacientes con diagnóstico de Parkinson.

    Directory of Open Access Journals (Sweden)

    Tomás Zamora

    2009-10-01

    Full Text Available Se realizó un estudio descriptivo retrospectivo en los pacientes remitidos por alteraciones motoras, atribuidas a enfermedad de Parkinson desde enero, 1995 a junio, 1999 en el Hospital Universitario San José y en el Centro de Atención Ambulatoria del Instituto de Seguro Social, Cauca. Se encontraron 19 casos de parkinsonismo por calcioantagonistas. Se hace énfasis en la presentación clínica y en la importancia de buscar antecedentes sobre fármacos prescritos y factores asociados con el fenómeno o trastorno motor. Se presentan resultados, se discuten los hallazgos clínicos y se revisa la literatura del parkinsonismo inducido por calcioantagonistas.

  2. $\\alpha_s$ review (2016)

    CERN Document Server

    d'Enterria, David

    2016-01-01

    The current world-average of the strong coupling at the Z pole mass, $\\alpha_s(m^2_{Z}) = 0.1181 \\pm 0.0013$, is obtained from a comparison of perturbative QCD calculations computed, at least, at next-to-next-to-leading-order accuracy, to a set of 6 groups of experimental observables: (i) lattice QCD "data", (ii) $\\tau$ hadronic decays, (iii) proton structure functions, (iv) event shapes and jet rates in $e^+e^-$ collisions, (v) Z boson hadronic decays, and (vi) top-quark cross sections in p-p collisions. In addition, at least 8 other $\\alpha_s$ extractions, usually with a lower level of theoretical and/or experimental precision today, have been proposed: pion, $\\Upsilon$, W hadronic decays; soft and hard fragmentation functions; jets cross sections in pp, e-p and $\\gamma$-p collisions; and photon F$_2$ structure function in $\\gamma\\,\\gamma$ collisions. These 14 $\\alpha_s$ determinations are reviewed, and the perspectives of reduction of their present uncertainties are discussed.

  3. Analysis of the problems of induced draft fans in a carbo-electric power station; Analisis de la problematica de ventiladores de tiro inducido de una central carboelectrica

    Energy Technology Data Exchange (ETDEWEB)

    Diaz Sanchez, Valentin de Jesus; Vital Flores, Francisco [LAPEM, Comision Federal de Electricidad (Mexico)

    2007-11-15

    The induced draft fans of the 350 MW units of a Thermo-electric power plant presented problems consisting of the failure of the capacity of gases extraction, together with the presence of cracks in the blades; this condition was observed since the stage of putting into service. Consequently, losses have been originated in the availability in two units, as well as, losses due to the manufacture of new impellers, which also originated that, in some cases, that the measures of the impellers, locally manufactured, differed from the originals, resulting in differences in the unit's efficiency. [Spanish] Los ventiladores tiro inducido de las unidades de 350 MW de una Central Termoelectrica presentaban una problematica consistente en la falla de capacidad de extraccion de gases, aunado a la presencia de fracturas en las aspas de los impulsores, esta condicion se observo desde la etapa de puesta en servicio. En consecuencia se han ocasionado perdidas de disponibilidad en dos unidades, asi como tambien, perdidas debido a la fabricacion de nuevos impulsores, lo que tambien origino que, en algunos casos, las medidas de los impulsores, fabricados localmente, diferian de los originales, dando como resultado diferencias en la eficiencia de las unidades.

  4. The $\\alpha-\\alpha$ fishbone potential revisited

    CERN Document Server

    Day, J P; Elhanafy, M; Smith, E; Woodhouse, R; Papp, Z

    2011-01-01

    The fishbone potential of composite particles simulates the Pauli effect by nonlocal terms. We determine the $\\alpha-\\alpha$ fishbone potential by simultaneously fitting to two-$\\alpha$ resonance energies, experimental phase shifts and three-$\\alpha$ binding energies. We found that essentially a simple gaussian can provide a good description of two-$\\alpha$ and three-$\\alpha$ experimental data without invoking three-body potentials.

  5. Modulación de la actividad dopa-decarboxilasa central evaluada mediante PET con 18-F-dopa inducida por la administración crónica de levodopa en macacos con parkinsonismo inducido por MPTP

    OpenAIRE

    M. Riverol; Luquin, M R

    2013-01-01

    La enfermedad de Parkinson (EP) es una entidad frecuentre que afecta fundamentalmente a personas de edad avanzada. Los fármacos más utilizados para el control de los síntomas de esta entidad son la levodopa y los agonistas dopaminérgicos. Diversos estudios de tomografía de emisión de positrones (PET) con 18F-fluorodopa y DAT-scan realizados en pacientes tratados han mostrado, que tras 5 años dde tratamiento, la actividad dopa-descarboxilasa y del transportador de dopamina, fue mayor en los pa...

  6. Alpha One Foundation

    Science.gov (United States)

    ... Tested Find Support Find Doctor What Is Alpha-1? Alpha-1 Antitrypsin Deficiency (Alpha-1) is a ... results for inhaled augmentation More News Our Number One Goal: Find a cure for Alpha-1. Website ...

  7. Desempeño reproductivo del bocachico (Prochilodus magdalenae, Steindachner, 1878) inducido en un mismo año.

    OpenAIRE

    Mar P., Elkin; Petro M., Roberto; Atencio G, Víctor

    2003-01-01

    Prochilodus magdalenae es la principal especie pesquera continental y la cuarta cultivada en Colombia. En su ambiente natural se reproduce en el cauce principal de los ríos, en el período lluvioso y lo hace una sola vez al año. No se reproduce en confinamiento por lo que la obtención de semillas para los programas de repoblamiento y fomento piscícola se obtienen mediante inducciones hormonales, principalmente con extracto pituitario de carpa (EPC). Para mantener la oferta de alevi...

  8. Calculus of radiolytic products generation in water due to alpha radiation. Determination of the spent nuclear fuels matrix alteration rate Determination of velocity of spent fuel matrix; Calculo de la generacion de productos radioliticos en agua por radiacion {alpha}. Determinacion de la velocidad de alteracion de la matriz del combustible nuclear gastado

    Energy Technology Data Exchange (ETDEWEB)

    Quinones, J.; Serrano, J.; Diaz Arocas, P.; Rodriguez Almazan, J. L. [Ciemat. Madrid (Spain); Bruno, J.; Cera, E.; Merino, J.; Esteban, J. A.; Martinez-Esparza, A. [Enresa. Madrid (Spain)

    2000-07-01

    The generation of radiolytic products as a result of alpha radiation in the surface of the spent fuel is a key process in order to understand how the it becomes degraded in repository conditions. The present work has established a radiolytic model based on a set of reactions involving fuel oxidation-dissolution and radiolytic products recombination. It also includes the decrease of the dose rates as the main alpha emitters decay away. Four cases, with varying parameters of the system, have been assessed. The results show a decrease in both the concentration of the radiolytic products in the gap water and the degradation of the fuel matrix. It has been estimated that in the period of the evaluation (10''6 years) up to 52% of the pellet is altered in the conservative cases, whereas only 11% is altered in the realistic cases. No significant differences were observed when the carbonates reactions were included in the system. (Author)

  9. Crystallochemical study of amides derived from 6{alpha}, 7{beta}-diidroxivoacapan-17{beta}-oic acid by X-ray diffraction; Estudo cristaloquimico de amidas derivadas do acido 6{alpha}, 7{beta}-di- hidroxivouacapan-17 {beta}-oico por difracao de raios-X

    Energy Technology Data Exchange (ETDEWEB)

    Branco, Marcello Cardoso; Prado Gambardella, Maria Teresa do [Sao Paulo Univ., Sao Carlos, SP (Brazil). Inst. de Quimica. Dept. de Quimica e Fisica Molecular

    1995-12-31

    Abstract. The 6{alpha}, 7{beta}-diidroxivoacapan-17{beta}-oic acid (DVA) is a Furane-diterpene isolated from Peterodon genus. It has anti inflammatory and analgesic properties. The purpose of this work is the characterization of amides derived from DVA, in order to understand the relationship between Chemical Structure and Biological Activity of Vouacapanes. The structures of DVA derivatives will be solved by single-crystal X-ray diffraction. (author) 15 refs., 2 figs.

  10. Crystallochemical study of esters derived from 6{alpha}, 7{beta}-diidroxivouacapan-17{beta}-oic acid by x-ray diffraction; Estudo cristaloquimico de esteres derivados do acido 6{alpha}, 6{beta}-di-hidroxivouacapan-17{beta}-oico por difracao de raios-X

    Energy Technology Data Exchange (ETDEWEB)

    Abrahao Junior, Odonirio [Sao Paulo Univ., Sao Carlos, SP (Brazil). Inst. de Quimica

    1995-12-31

    The 6{alpha}, 7{beta}-diidroxivoacapan-17{beta}-oic acid (DVA) is a Furane-diterpene isolated from Peterodon genus. It has anti-inflammatory and analgesic properties. The purpose of this work is the characterisation by x-ray single crystal diffraction technique of esters derived from DVA, to understand the relationship between chemical structure and biological activity of vouacapanes. (author) 15 refs.

  11. La inundación de octubre de 1879 en el Bajo Segura. Magnitud y efectos inducidos

    Directory of Open Access Journals (Sweden)

    Calvo García-Tornel, F.

    2001-03-01

    Full Text Available This article constitutes a approach in the analysis of the catastrophic flood occurred on October 1875 in the Guadalentin Basin and Lower Segura river. In first place, event implications within scientist, political and socioeconomic contexts areis described, as well as the magnitude of the same, valued in terms of material damages and morphological effects. Next the physical factors that contributes to the disaster are studied, revising the pluviométric and hydrological data and deducing another new (kinetic energy of the rain, rainfall erosivity, hydraulic parameters for the methods of Manning and MEI. Finally the situation of the basin in relation to the risk is shown, emphasizing the effects derived of the works of defense and other civil structures like an clear indicator of the environmental fragility imposed for the human action.

    Este artículo constituye una nueva aproximación en el análisis de la catastrófica inundación ocurrida los días 14 y 15 de octubre de 1875 en la cuenca del Guadalentín y vegas media y baja del Segura, dedicando especial atención a esta última, por su extraordinaria gravedad y mayor grado de información. En primer lugar se describe la trascendencia del suceso dentro de los ámbitos científico, político y socio-económico, así como la magnitud del mismo, valorada en términos de daños materiales y efectos geo- morfológicos. A continuación se estudian los factores físicos que contribuyeron a la catástrofe, haciendo una revisión de los datos pluviométricos e hidrológicos existentes y deduciendo otros nuevos (energía cinética de la lluvia, erosividad pluvial, obtención de parámetros hidráulicos por los métodos de Manning y MEI. Finalmente se muestra la situación de la cuenca ante el riesgo, destacando los efectos derivados de las obras de defensa y de otras infraestructuras como un claro indicador de la fragilidad de este medio impuesta por el hombre.

  12. Estudio histopatológico e inmunohistoquímico de páncreas en perros diabéticos inducidos con aloxano Histopathologic and immunohistochemical study of pancreas in alloxan-induced diabetic dogs

    Directory of Open Access Journals (Sweden)

    V Cubillos

    2008-01-01

    Full Text Available El presente estudio se llevó a cabo en perros diabéticos tipo I inducidos con Aloxano®, con el propósito de evaluar las lesiones microscópicas presentes en páncreas y relacionarlas con la presencia o ausencia de insulina en los islotes de Langerhans a distintos tiempos posinducción. Se utilizaron 20 caninos mestizos, machos enteros de 4 a 7 años de edad, los cuales fueron divididos en 2 grupos: Control (n = 5 y Experimental (n = 15. Este último fue subdividido en grupos de 3 animales cada uno y sometido a la inducción de Diabetes mellitus mediante la administración e. v. de Aloxano® en dosis única de 75 mg/kg. Los animales fueron sacrificados a distintos tiempos posinducción (p.i.: 2h, 24hy 7d, 14d, 21d, tomándose muestras de páncreas para examen histopatológico e inmunohistoquímico para determinar insulina y Ki-67. Para cada subgrupo experimental se consideró un perro Control. El estado diabético del Grupo Experimental se comprobó mediante la evaluación de glucosa y fructosamina en plasma. La diabetes fue confirmada por la instauración de hiperglicemia sostenida e hiperfructosaminemia a partir de los 7 días p.i. Los resultados histopatológicos mostraron una disminución significativa (P The aim of this study was to evaluate pancreatic microscopic lesions with the presence or absence of insulin in Langerhans islets at different times post-induction (p.i. in alloxan-induced diabetic type I dogs. A group of 20 mixed breed, male adult dogs were used, subdivided in 2 groups: Control (n = 5 and Experimental (n = 15. The Experimental Group was subdivided into groups of 3 animals each which were alloxan-induced intravenously (75 mg/kg. Dogs were sacrificed at different times p.i. (2 hours, 24 hours, 7 days, 14 days, 21 days. Pancreatic samples were taken for histopathologic and immunohistochemical study against insulin and Ki-67. The Control Group considered 5 healthy dogs, one for each Experimental Group. Plasmatic evaluation

  13. Factors associated with chloroquine induced pruritus during malaria treatment in Mozambican University students Factores asociados a la aparición de prurito por cloroquina durante el tratamiento de la malaria en estudiantes universitarios de Mozambique

    Directory of Open Access Journals (Sweden)

    Helena Gama

    2009-08-01

    Full Text Available Introduction: It has been suggested that reductions in chloroquine use may be followed by a resurgence of chloroquine-susceptible falciparum malaria, and chloroquine might once again be an effective treatment choice, which renews the importance of aspects related to its use and misuse. Therefore, we aimed to estimate the prevalence of chloroquine-induced pruritus and to identify risk factors for its occurrence in Mozambican University students. Methods: A cross-sectional study was conducted at a private University in Maputo. Students were approached in the classrooms to complete a self-administered questionnaire covering sociodemographic characteristics, number of previous malaria episodes, utilization of antimalarial drugs, and life prevalence of chloroquine induced pruritus. Results: Among 795 respondents, 77.4% (601/777 reported at least one malaria episode and 73.2% (542/740 had used chloroquine before. The life-prevalence of chloroquine-induced pruritus was 30.1% (158/525. Pruritus tended to be more frequent when chloroquine was used for treatment compared with prophylaxis only (31.2% vs. 10.3%, pIntroducción: Se ha sugerido que la reducción en el uso de la cloroquina puede derivar en el resurgimiento de la malaria falciparum sensible a la cloroquina, por lo que ésta puede volver a ser un tratamiento efectivo de elección, renovando la importancia de aspectos relacionados con su uso y su mal uso. Se pretende estimar la prevalencia de prurito inducido por cloroquina e identificar los factores de riesgo asociados a su ocurrencia en estudiantes universitarios de Mozambique. Métodos: Se realizó una encuesta transversal en una Universidad privada de Mozambique. Los estudiantes fueron abordados en las aulas para completar un cuestionario autoadministrado, que contenía datos sociodemográficos e información sobre el número de episodios previos de malaria, la utilización de fármacos antipalúdicos y la prevalencia de prurito inducido por

  14. Estudio histopatológico e inmunohistoquímico de páncreas en perros diabéticos inducidos con aloxano Histopathologic and immunohistochemical study of pancreas in alloxan-induced diabetic dogs

    OpenAIRE

    V. CUBILLOS; C López; Alberdi, A.

    2008-01-01

    El presente estudio se llevó a cabo en perros diabéticos tipo I inducidos con Aloxano®, con el propósito de evaluar las lesiones microscópicas presentes en páncreas y relacionarlas con la presencia o ausencia de insulina en los islotes de Langerhans a distintos tiempos posinducción. Se utilizaron 20 caninos mestizos, machos enteros de 4 a 7 años de edad, los cuales fueron divididos en 2 grupos: Control (n = 5) y Experimental (n = 15). Este último fue subdividido en grupos de 3 animales cada u...

  15. Tolerancia al daño inducido bajo solicitaciones de contacto cíclicas en carburos cementados WC-Co//Tolerance induced damage under cyclic contact loading of WC-Co cemented carbides

    OpenAIRE

    David Coureaux‐Mustelier; Anna Ingebrand; Alexey Goéz‐Úsuga; Luís Miguel Llanes‐Pitarch

    2014-01-01

    El comportamiento mecánico de los carburos cementados WC-Co ha sido estudiado en detalle teniendo en cuenta los defectos preexistentes del material (daño intrínseco). Sin embargo, la información sobre los efectos del daño inducido en servicio (daño extrínseco) en la integridad estructural de estos materiales esescasa. En este contexto, en este trabajo se evalúa la influencia del daño extrínseco en la resistencia mecánica residual de dos calidades con microestructuras diferentes. Para ello, se...

  16. Estudio prospectivo randomizado doble ciego para valorar la seguridad y eficacia de palonosetrón más aprepitant versus granisetrón en la profilaxis de la emesis inducida por quimioterapia en el transplante de precursores hemotopoyéticos

    OpenAIRE

    Tenorio Núñez, María Concepción

    2013-01-01

    El estudio de las náuseas y vómitos inducidos por quimioterapia (NVIQ) en el acondicionamiento de los trasplantes de precursores hematopoyéticos (TPH) es escaso. Las peculiaridades de este tipo de procedimiento requieren una consideración especial y diferente a la administración de quimioterapia en el contexto del tratamiento de una neoplasia puesto que conlleva un peor control de las NVIQ. El objetivo principal de la tesis consistió en evaluar la eficacia en términos de respuesta completa (R...

  17. Efecto Protector de Peumus Boldus en ratas con toxicidad hepática inducida por Paracetamol

    Directory of Open Access Journals (Sweden)

    Christiam Ochoa

    2008-01-01

    Full Text Available Objetivo: Comprobar el efecto protector hepático del extracto acuoso de boldo (EAB (Peumus boldus al daño hepático inducido por acetaminofén (paracetamol. Diseño: Analítico, experimental, aleatorizado, completo ¿ experimento verdadero. Realizado en el Instituto de Patología de la Facultad de Medicina de UNMSM. Material y método. 30 Ratas Holtzman macho de 250g y dos meses se dividieron en 5 grupos aleatoriamente, grupo blanco, control paracetamol 200mg/kg y 3 experimentales tratados con EAB a 80 mg/kg, 120 mg/kg y 160 mg/kg respectivamente. Se administró EAB de 80 mg/kg, 120 mg/kg y 160 mg/kg vía orogástrica. Luego de media hora se administró paracetamol 200mg/kg i.p. a los grupos control y experimentales. Este procedimiento se repitió por 5 días. Se tomó pruebas de transaminasas (TGP basal y final en sangre. Se utilizó la prueba de Kruskal-Wallis para analizar la data y un p<0.05 fue considerado significante. Se estudió la anatomopatología de los hígados y se tomaron muestras de tejido teñidas con HE. Resultados: Existe diferencia significativa en los niveles de transaminasas (TGP entre grupos (p<0.05. El control obtuvo 196.6 U/L +- 38.1 (TGP mientras que los experimentales como máximo 55.6 U/l. Las muestras control evidencian signos de lesión hepática, degeneración grasa, congestión sinusoidal y centrolobulillar, y necrosis celular. Sin embargo los grupos experimentales no presentan signos de lesión celular y hay ausencia de inflamación. Conclusiones: El boldo tiene un efecto protector hepático al daño inducido por paracetamol en ratas Holtzmann.

  18. EFECTO PROTECTOR DE PEUMUS BOLDUS EN RATAS CON TOXICIDAD HEPÁTICA INDUCIDA POR PARACETAMOL

    Directory of Open Access Journals (Sweden)

    Christiam Ochoa

    2012-02-01

    Full Text Available Objetivo: Comprobar el efecto protector hepático del extracto acuoso de boldo (EAB (Peumus boldus al daño hepático inducido por acetaminofén (paracetamol. Diseño: Analítico, experimental, aleatorizado, completo – experimento verdadero. Realizado en el Instituto de Patología de la Facultad de Medicina de UNMSM. Material y método. 30 Ratas Holtzman macho de 250g y dos meses se dividieron en 5 grupos aleatoriamente, grupo blanco, control paracetamol 200mg/kg y 3 experimentales tratados con EAB a 80 mg/kg, 120 mg/kg y 160 mg/kg respectivamente. Se administró EAB de 80 mg/kg, 120 mg/kg y 160 mg/kg vía orogástrica. Luego de media hora se administró paracetamol 200mg/kg i.p. a los grupos control y experimentales. Este procedimiento se repitió por 5 días. Se tomó pruebas de transaminasas (TGP basal y final en sangre. Se utilizó la prueba de Kruskal-Wallis para analizar la data y un p<0.05 fue considerado significante. Se estudió la anatomopatología de los hígados y se tomaron muestras de tejido teñidas con HE. Resultados: Existe diferencia significativa en los niveles de transaminasas (TGP entre grupos (p<0.05. El control obtuvo 196.6 U/L +- 38.1 (TGP mientras que los experimentales como máximo 55.6 U/l. Las muestras control evidencian signos de lesión hepática, degeneración grasa, congestión sinusoidal y centrolobulillar, y necrosis celular. Sin embargo los grupos experimentales no presentan signos de lesión celular y hay ausencia de inflamación. Conclusiones: El boldo tiene un efecto protector hepático al daño inducido por paracetamol en ratas Holtzmann.

  19. Desempeño reproductivo del bocachico Prochilodus magdalenae inducido dos veces en un mismo año

    Directory of Open Access Journals (Sweden)

    Víctor Atencio G.

    2013-03-01

    Full Text Available Objetivo. Evaluar el desempeño reproductivo del bocachico (Prochilodus magdalenae sometido a dos inducciones hormonales con extracto pituitario de carpa (EPC en un mismo año. Materiales y métodos. 23 hembras, en fase de maduración final, fueron inducidas con 5mg EPC/Kg de peso vivo, en dos aplicaciones, inicialmente 10% y doce horas después 90% restante. A los machos fue aplicado 80% de la dosis total de las hembras. Resultados. Después de la primera inducción hormonal, las hembras estuvieron aptas nuevamente a los 97.6±12.4 días. El índice de ovulación en ambas inducciones fue de 0.91 (21/23. La fecundidad absoluta (g-ovocitos/hembra no presentó diferencias significativa entre la primera y segunda inducción (36.2 y 44.6 g-ovocitos/hembra, respectivamente (p>0.05; pero cuando se expresó en número de ovocitos/hembra se observó diferencia significativa (p<0.05, siendo mayor en la primera inducción (53535 ovocitos/hembra que en la segunda (40658 ovocitos/hembra. La fecundidad relativa, expresada tanto en g-ovocitos/Kg-hembra como ovocitos/Kg-hembra, mostraron diferencia significativa, siendo mayor en la primera inducción (p<0.05. La tasa de fecundación (73.9±19.6% y eclosión (56.9±17.9% fueron mayores en la primera inducción, comparadas con la segunda (55.6±21.1% y 35.6±20.7%, respectivamente (p<0.05. Conclusiones. Después de una inducción hormonal se requiere de aproximadamente tres meses para que una hembra de bocachico alcance nuevamente la maduración final y esté apta para una nueva inducción hormonal. El índice de ovulación no fue afectado por una segunda inducción en un mismo año, pero la fecundidad absoluta y relativa puede disminuirse entre 24 y 66% y las tasas de fecundación y eclosión entre 23 y 36%.

  20. Ab initio alpha-alpha scattering

    CERN Document Server

    Elhatisari, Serdar; Rupak, Gautam; Epelbaum, Evgeny; Krebs, Hermann; Lähde, Timo A; Luu, Thomas; Meißner, Ulf-G

    2015-01-01

    Processes involving alpha particles and alpha-like nuclei comprise a major part of stellar nucleosynthesis and hypothesized mechanisms for thermonuclear supernovae. In an effort towards understanding alpha processes from first principles, we describe in this letter the first ab initio calculation of alpha-alpha scattering. We use lattice effective field theory to describe the low-energy interactions of nucleons and apply a technique called the adiabatic projection method to reduce the eight-body system to an effective two-cluster system. We find good agreement between lattice results and experimental phase shifts for S-wave and D-wave scattering. The computational scaling with particle number suggests that alpha processes involving heavier nuclei are also within reach in the near future.

  1. DEGRADACIÓN DE SUELOS POR ACTIVIDADES ANTRÓPICAS EN EL NORTE DE TAMAULIPAS, MÉXICO

    Directory of Open Access Journals (Sweden)

    M. Espinosa Ramírez

    2011-01-01

    Full Text Available La degradación de los suelos es un proceso que puede estar inducido por el hombre y que disminuye la capacidad actual y/o futura para sostener la vida humana. En este trabajo se estudia la Zona II de la Cuenca de Burgos (México con el objetivo de evaluar y conocer los distintos tipos de degradación, originada por la acción antrópica. Para ello se delimitaron los tipos de suelo, se seleccionaron áreas representativas para realizar perfiles de suelos y se evaluó la degradación de los mismos siguiendo la metodología de ASSOD (Van Lyden, 1997. Los resultados muestran como el 74% del área estudiada presenta evidencias de degradación. Los tipos dominantes son: erosión hídrica, compactación y erosión eólica. Las causas principales son el sobrepastoreo y las prácticas agrícolas superficiales, a lo que hay que añadir las actividades industriales recientes de PEMEX. La degradación más acusada se presenta en Calcisoles. Los Leptosoles, por el contrario, tienen menor degradación, pero es en donde se da la mayor actividad industrial.

  2. Ab initio alpha-alpha scattering

    Science.gov (United States)

    Elhatisari, Serdar; Lee, Dean; Rupak, Gautam; Epelbaum, Evgeny; Krebs, Hermann; Lähde, Timo A.; Luu, Thomas; Meißner, Ulf-G.

    2015-12-01

    Processes such as the scattering of alpha particles (4He), the triple-alpha reaction, and alpha capture play a major role in stellar nucleosynthesis. In particular, alpha capture on carbon determines the ratio of carbon to oxygen during helium burning, and affects subsequent carbon, neon, oxygen, and silicon burning stages. It also substantially affects models of thermonuclear type Ia supernovae, owing to carbon detonation in accreting carbon-oxygen white-dwarf stars. In these reactions, the accurate calculation of the elastic scattering of alpha particles and alpha-like nuclei—nuclei with even and equal numbers of protons and neutrons—is important for understanding background and resonant scattering contributions. First-principles calculations of processes involving alpha particles and alpha-like nuclei have so far been impractical, owing to the exponential growth of the number of computational operations with the number of particles. Here we describe an ab initio calculation of alpha-alpha scattering that uses lattice Monte Carlo simulations. We use lattice effective field theory to describe the low-energy interactions of protons and neutrons, and apply a technique called the ‘adiabatic projection method’ to reduce the eight-body system to a two-cluster system. We take advantage of the computational efficiency and the more favourable scaling with system size of auxiliary-field Monte Carlo simulations to compute an ab initio effective Hamiltonian for the two clusters. We find promising agreement between lattice results and experimental phase shifts for s-wave and d-wave scattering. The approximately quadratic scaling of computational operations with particle number suggests that it should be possible to compute alpha scattering and capture on carbon and oxygen in the near future. The methods described here can be applied to ultracold atomic few-body systems as well as to hadronic systems using lattice quantum chromodynamics to describe the interactions of

  3. Ab initio alpha-alpha scattering.

    Science.gov (United States)

    Elhatisari, Serdar; Lee, Dean; Rupak, Gautam; Epelbaum, Evgeny; Krebs, Hermann; Lähde, Timo A; Luu, Thomas; Meißner, Ulf-G

    2015-12-01

    Processes such as the scattering of alpha particles ((4)He), the triple-alpha reaction, and alpha capture play a major role in stellar nucleosynthesis. In particular, alpha capture on carbon determines the ratio of carbon to oxygen during helium burning, and affects subsequent carbon, neon, oxygen, and silicon burning stages. It also substantially affects models of thermonuclear type Ia supernovae, owing to carbon detonation in accreting carbon-oxygen white-dwarf stars. In these reactions, the accurate calculation of the elastic scattering of alpha particles and alpha-like nuclei--nuclei with even and equal numbers of protons and neutrons--is important for understanding background and resonant scattering contributions. First-principles calculations of processes involving alpha particles and alpha-like nuclei have so far been impractical, owing to the exponential growth of the number of computational operations with the number of particles. Here we describe an ab initio calculation of alpha-alpha scattering that uses lattice Monte Carlo simulations. We use lattice effective field theory to describe the low-energy interactions of protons and neutrons, and apply a technique called the 'adiabatic projection method' to reduce the eight-body system to a two-cluster system. We take advantage of the computational efficiency and the more favourable scaling with system size of auxiliary-field Monte Carlo simulations to compute an ab initio effective Hamiltonian for the two clusters. We find promising agreement between lattice results and experimental phase shifts for s-wave and d-wave scattering. The approximately quadratic scaling of computational operations with particle number suggests that it should be possible to compute alpha scattering and capture on carbon and oxygen in the near future. The methods described here can be applied to ultracold atomic few-body systems as well as to hadronic systems using lattice quantum chromodynamics to describe the interactions of

  4. Análisis del efecto chimenea en fachadas ventiladas opacas mediante correlaciones del flujo másico inducido. Aplicación para el dimensionado de anchos de cámara

    Directory of Open Access Journals (Sweden)

    Suárez, C.

    2015-06-01

    Full Text Available A general analysis of the stack effect problem applied to opaque ventilated facades is made in this paper. From an energetic point of view, the design and optimization of ventilated facades, require a deep understanding of the thermal and fluid dynamic phenomena that take place in the air gap, and, due to the complexity of these phenomena, the optimal design is a challenge to architects and engineers. As a main result, useful correlations for calculating the induced mass flow into the ventilated cavity are proposed depending on the geometry and the temperature difference. The set of application of the correlation covers the usual range of interest in opaque ventilated facades. It is also made a sensitive analysis of the induced flow with the indicated parameters.En el presente artículo, se realiza un análisis general del problema del efecto chimenea aplicado a las fachadas ventiladas opacas. Desde un punto de vista energético, el diseño y la optimización de las fachadas ventiladas requiere un profundo conocimiento de los fenómenos térmicos y fluidodinámicos que se producen en la cámara ventilada y debido a la complejidad de estos fenómenos, el diseño óptimo supone un reto para arquitectos e ingenieros. Como resultado principal, se proponen unas correlaciones útiles para el cálculo del flujo másico inducido en la cavidad ventilada en función de la geometría y de la diferencia de temperaturas. El conjunto de casos de aplicación de las correlaciones cubre el rango habitual de interés en fachadas ventiladas opacas. Asimismo se realiza un análisis de sensibilidad del caudal inducido al variar los parámetros señalados.

  5. Faddeev calculation of 3 alpha and alpha alpha Lambda systems using alpha alpha resonating-group method kernel

    CERN Document Server

    Fujiwara, Y; Kohno, M; Suzuki, Y; Baye, D; Sparenberg, J M

    2004-01-01

    We carry out Faddeev calculations of three-alpha (3 alpha) and two-alpha plus Lambda (alpha alpha Lambda) systems, using two-cluster resonating-group method kernels. The input includes an effective two-nucleon force for the alpha alpha resonating-group method and a new effective Lambda N force for the Lambda alpha interaction. The latter force is a simple two-range Gaussian potential for each spin-singlet and triplet state, generated from the phase-shift behavior of the quark-model hyperon-nucleon interaction, fss2, by using an inversion method based on supersymmetric quantum mechanics. Owing to the exact treatment of the Pauli-forbidden states between the clusters, the present three-cluster Faddeev formalism can describe the mutually related, alpha alpha, 3 alpha and alpha alpha Lambda systems, in terms of a unique set of the baryon-baryon interactions. For the three-range Minnesota force which describes the alpha alpha phase shifts quite accurately, the ground-state and excitation energies of 9Be Lambda are...

  6. Un extracto de Punica granatum L. (BLBu sobre la apoptosis inducida por virus influenza A y B

    Directory of Open Access Journals (Sweden)

    Isis Casadelvalle Pérez

    2006-01-01

    Full Text Available La apoptosis ha sido ampliamente reconocida como un mecanismo intrínseco de autodestrucción en las células animales. Este fenómeno puede ser inducido por múltiples factores, entre los que se pueden citar algunos virus, que lo utilizan como vía de diseminación en el hospedero. Para contrarrestar este mecanismo se han usado extractos obtenidos de plantas con propiedades antivirales, los cuales, intuitivamente, pudieran ejercer su efecto sobre la apoptosis inducida por los virus. En el presente trabajo se estudió el efecto de un extracto natural de Punica granatum L. sobre la apoptosis inducida por dos virus: influenza A e influenza B en dos líneas celulares: MDCK y células Vero. Se determinó la citotoxicidad del extracto y se estimó que el valor de CC50 para la línea celular MDCK resulta de (400 ± 59 mg/mL y en las células Vero de (137,3 ± 23 mg/mL. A concentraciones no citotóxicas el extracto no indujo la fragmentación del ADN. El efecto del extracto sobre las células infectadas con los virus influenza A/ Japan/10/99(H3N2, influenza B/Beijing/88 fue evaluado mediante la técnica del MTT y el análisis de la fragmentación del ADN, técnicas usadas para identificar el proceso de muerte apoptótica. El proceso de apoptosis fue inhibido por el extracto a todas las concentraciones y tiempos ensayados. A partir de los resultados, se infiere la existencia de mecanismos comunes de inducción de la apoptosis por estos virus que son interferidos por el extracto natural ensayado.

  7. SEÑALES PRODUCIDAS POR Rhizobium leguminosarum EN LA INTERACCIÓN CON FRIJOL COMÚN (Phaseolus vulgaris L.

    Directory of Open Access Journals (Sweden)

    María C. Nápoles García

    2016-01-01

    Full Text Available La interacción Rhizobium-leguminosas depende de un complejo intercambio de señales, que se mantiene durante todo el proceso simbiótico y de las que solamente una combinación correcta permitirá una simbiosis eficiente. Estas plantas secretan flavonoides, reconocidos por bacterias compatibles y que inducen sus genes nod. Estos codifican las proteínas que sintetizan y exportan lipoquitooligosacáridos conocidos como factores Nod. Los factores Nod activan los procesos de infección e inician la división celular en la raíz, hasta la formación del nódulo y participan también en la fijación biológica del nitrógeno. Existen evidencias de que el uso de inductores de los genes nod incrementa la nodulación en algunas leguminosas. El objetivo de este trabajo fue estudiar la producción de algunas moléculas señales, inducidas por la isoflavona genisteína en una cepa de R. leguminosarum y evaluar el impacto de esa inducción en el efecto del inóculo sobre plantas de frijol común. La fracción lipídica en los inóculos fue extraída con n-butanol y analizada por cromatografía de capa fina, cromatografía líquida de alta resolución y cromatografía gaseosa acoplada a un espectrómetro de masas. En los inóculos inducidos con genisteína se detectó una cantidad superior de lipooligosacáridos (factores de nodulación y de ácidos grasos de alto peso molecular, con diferencias significativas respecto a los controles sin inducir. En relación con ese enriquecimiento en moléculas señales, los inóculos inducidos con genisteína, mostraron un efecto positivo en las plantas de frijol de la variedad Cubacueto 25-9, con mayor número de nódulos y contenido de clorofila que las plantas no inoculadas (control.

  8. Review of alpha_s determinations

    CERN Document Server

    Pich, Antonio

    2013-01-01

    The present knowledge on the strong coupling is briefly summarized. The most precise determinations of alpha_s, at different energies, are reviewed and compared at the Z mass scale, using the predicted QCD running. The impressive agreement achieved between experimental measurements and theoretical predictions constitutes a beautiful and very significant test of Asymptotic Freedom, establishing QCD as the fundamental theory of the strong interaction. The world average value of the strong coupling is found to be alpha_s(M_Z^2)= 0.1186 \\pm 0.0007.

  9. Review of alpha_s determinations

    OpenAIRE

    Pich, Antonio

    2013-01-01

    The present knowledge on the strong coupling is briefly summarized. The most precise determinations of alpha_s, at different energies, are reviewed and compared at the Z mass scale, using the predicted QCD running. The impressive agreement achieved between experimental measurements and theoretical predictions constitutes a beautiful and very significant test of Asymptotic Freedom, establishing QCD as the fundamental theory of the strong interaction. The world average value of the strong coupl...

  10. Activity of the protector chlorophyllin or promoter of the genetic damage induced by the 1,2 dimethyl hydrazine; Actividad de la clorofilina protectora o promotora del dano genetico inducido por la 1,2 dimetil hidrazina

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero M, M.G

    2004-07-01

    The chlorophyllin (CHLN) it is a porphyrin of soluble nutritious grade in water, derived of the chlorophyll that includes in their structure a copper atom. It has been reported that this pigment can act as anti mutagen, reducing the damage to the DNA caused by physical or chemical agents of direct or indirect action. Their anti carcinogen action has also been studied during the initiation phase induced for carcinogen as the aflatoxins and heterocyclic amines. In contrast the reports have increased on a probable promoter activity of the CHLN on the induced genetic damage. This effect was seen for the first time before the damage induced by alkylating agents in Salmonella. Recently it has been observed with the damage induced by gamma radiation, ENU and CrO{sub 3} in somatic cells of the wing of Drosophila and in the induction of tumors for 1,2-dimethylhydrazine (DMH) in mice. Presently study is evaluated the protective effect or promoter of the CHLN before the genetic damage induced by 1,2-dimethylhydrazine, by means of the bioassay mutation and somatic recombination (SMART) in the wing of Drosophila melanogaster. Its were pretreated with CHLN or SAC to transheterocygotes larvas for two locus of the chromosome three mwh+/+flr{sup 3}; later on they are retarded the chronic treatment with DMH 0, 1, 2 and 3 days. It was measured the toxicity and the speed of development of the treated individuals. The wings of those adults that emerged were analyzed to register the number and the size of stains. The results indicated: differences in the viability of the individuals of the groups SAC + DMH vs CHLN + DMH only in the treated immediately after the pretreatment (DRT-0) that the CHLN doesn't modify the rate of the treated individuals development. The results of somatic mutation indicated that the CHLN has a protective effect only immediately after the pretreatment (DRT-0) however in DRT-1, 2 and 3 showed a promoter effect of genetic damage. (Author)

  11. Thermal annealing of high dose radiation induced damage at room temperature in alkaline. Stored energy, thermoluminescence and coloration; Aniquilacion termica de dano inducido por irradiacion a altas dosis en haluros alcalinos a 300 k. energia almacenda. Termoluminiscencia y coloracion

    Energy Technology Data Exchange (ETDEWEB)

    Delgado, L.

    1980-07-01

    The possible relation between stored energy, thermoluminescence and colour centre annealing in gamma and electron irradiated alkali halides is studied. Thermoluminescence occurs at temperature higher than the temperature at which the main stored energy peak appears. No stored energy release is detected in additively coloured KC1 samples. Plastic deformation and doping with Ca and Sr induce a stored energy spectrum different from the spectrum observed in pure and as cleaved samples, but the amount of stored energy does not change for a given irradiation dose.Capacity of alkali halides to store energy by irradiation increases as the cation size decreases. (Author) 51 refs.

  12. Action of the chlorophyllin on the genetic damage induced by gamma radiation in germinal cells of Drosophila Melanogaster; Accion de la clorofilina sobre el dano genetico inducido por radiacion gamma en celulas germinales de Drosophila Melanogaster

    Energy Technology Data Exchange (ETDEWEB)

    Cruces, M.P.; Pimentel, A.E.; Moreno, A.; Moreno, R. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2003-07-01

    The obtained results using somatic cells, they have evidenced that the chlorophyllin (CHLN) it can act inhibiting or increasing the damage caused by different mutagens. The objective of this investigation is to evaluate the effect of the CHLN on the damage induced by gamma radiation in germinal cells of Drosophila. Two tests were used, the lost of the X chromosome and the conventional test of lethal recessive bound to the sex (LRLS); both with a system of litters. The obtained results in both essays, indicated that the CHLN doesn't reduce the damage induced by the gamma radiation in none of the cellular monitored states. (Author)

  13. Modifier activity of the protoporphyrin IX of the clastogenic damage induced by gamma radiation in Drosophila melanogaster; Actividad modificadora de la protoporfirina IX del dano clastogenico inducido por radiacion gamma en Drosophila melanogaster

    Energy Technology Data Exchange (ETDEWEB)

    Martinez A, G. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)

    2007-07-01

    It has been demonstrated that the copper sodium chlorophyllin (CCS) it is a potent inhibitor of the one genetic damage induced by physical or chemical agents in systems like: bacteria, Drosophila, rainbow trout and mammals. Nevertheless it has been observed that under certain conditions it promotes it. In the laboratory of Drosophila of the ININ evidences have been obtained that the CCS increases the percentage of lethal embryonic dominant and post-embryonic induced by gamma radiation. One of the probable causes of this effect promoter, is the oxidizer stress that it could cause the metallic center of the CCS. The objective of this investigation it was the evaluation of the inhibitory action of the protoporphyrin IX (PP-IX) of the genetic damage induced by gamma radiation in the germinal line of Drosophila melanogaster. For such effect it was used the lethal dominant test by means of two protocols: one in the one that the PP-IX or CCS was administered to the females and the other one to the males. Females of genotype y/y and males of the canton-S stump were used. In both cases the males were treated with 40 Gy of gamma radiation. Its were count the embryonic lethal dominant (L-E) and those post-embryonic (L-PE) of the F1. The results indicated that after the one pretreatment with PP-IX to the crossed females with males treaties increase the percentage of L-E (P {<=} 0.001) and it diminished that of L-PE (P {<=} 0.001) compared with the sucrose control more radiation, however when it was pretreated with CCS also it was observed an increment in the percentage of L-E (P {<=} 0.001), but it doesn't present effect on that of L-PE. In contrast, when the males were pretreated, it was observed that the PP-IX tends to increase those L-E, but diminished the L-PE (P {<=} 0.05), however when it was pretreated with CCS was observed that increased the percentage of L-E (P {<=} 0.001) but diminished that of L-PE (P {<=} 0.001). It was concluded that none of the two pigments act as inhibitor of the damage; for the contrary one promoted it, and that the metallic center can possibly be the one responsible of the promoter effect observed. (Author)

  14. Magnitud del enfisema inducido por elastasa: Posible relación con el tipo de daño agudo pulmonar Elastase induced emphysema: Possible relationship with the type of acute lung injury

    OpenAIRE

    ANDREA VECCHIOLA C; PILAR CELIS L; PABLO SANDOVAL R; ALFONSO LEÓN F; ANDREA VILLAGRÁN T; ALEJANDRO RAMÍREZ M; GISELLA BORZONE T

    2009-01-01

    Introducción: El modelo de instilación intratraqueal de elastasa induce daño alveolar difuso y destrucción de la matriz extracelular con desarrollo de enfisema. Sin embargo, el hámster Syrian Golden desarrolla enfisema más severo que el de la rata Sprague-Dawley. Si bien se sabe que los eventos tempranos después de la instilación de elastasa determinan la magnitud del enfisema, se desconoce si existen diferencias entre especies en la respuesta pulmonar temprana. Objetivo: Evaluar si existen d...

  15. Simulation by the effect of the Sloshing induced by an earthquake in fuel pools of Cofrentes NPP; Simulacion mediante CFD del efecto del Sloshing inducido por un sismo en las piscinas de combustible C. N. Cofrentes

    Energy Technology Data Exchange (ETDEWEB)

    Sarti Fernandez, F.; Gavilan Moreno, C.; Paez Ortega, E.

    2012-07-01

    After analyzing the results of this study, it was concluded that the use of CFD tools brings a level of knowledge and detail of phenomena and superior to traditional methods derived effects. This, coupled with the reduction of time and costs of Dynamics Simulations, technological advances have been providing in recent years, its application makes it very interesting.

  16. Estimate of the damage in organs induced by neutrons in three-dimensional conformal radiotherapy; Estimacion del dano en organos inducido por neutrones en radioterapia conformada en 3D

    Energy Technology Data Exchange (ETDEWEB)

    Benites R, J. L. [Centro Estatal de Cancerologia de Nayarit, Servicio de Seguridad Radiologica, Calzada de la Cruz 118 sur, 63000 Tepic, Nayarit (Mexico); Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico); Uribe, M. del R., E-mail: jlbenitesr@prodigy.net.mx [Instituto Tecnico Superior de Radiologia, Calle Leon No. 129, 63000 Tepic, Nayarit (Mexico)

    2014-08-15

    By means of Monte Carlo methods was considered the damage in the organs, induced by neutrons, of patients with cancer that receive treatment in modality of three-dimensional conformal radiotherapy (3D-CRT) with lineal accelerator Varian Ix. The objective of this work was to estimate the damage probability in radiotherapy patients, starting from the effective dose by neutrons in the organs and tissues out of the treatment region. For that a three-dimensional mannequin of equivalent tissue of 30 x 100 x 30 cm{sup 3} was modeled and spherical cells were distributed to estimate the Kerma in equivalent tissue and the absorbed dose by neutrons. With the absorbed dose the effective dose was calculated using the weighting factors for the organ type and radiation type. With the effective dose and the damage factors, considered in the ICRP 103, was considered the probability of damage induction in organs. (Author)

  17. Process of defect formation in alkaline halogenides contaminated with Eu{sup 2+} induced by non ionizing radiation; Procesos de formacion de defectos en halogenuros alcalinos contaminados con Eu{sup 2+} inducidos por radiacion no ionizante

    Energy Technology Data Exchange (ETDEWEB)

    Pedroza M, M.; Melendrez, R.; Barboza F, M. [Centro de Investigacion en Fisica de la Universidad de Sonora, A.P. 5-088, 83190 Hermosillo, Sonora (Mexico); Castaneda, B. [UNISON, A.P. 1626, 83190 Hermosillo, Sonora (Mexico)

    2004-07-01

    The creation of defects in polluted alkaline halogenides with divalent impurities exposed to ionizing radiation is explained by means of the creation of auto trapped excitons (STE), which can be formed by means of the excitement of the halogen ion or through the trapping of electrons in centers V{sub K} taken place during the process of ionization of the halogen ion. The luminescent recombination of the exciton auto trapped produces a characteristic exciton luminescence and the recombination non radiative causes the formation of the Frenkel type defects, even of centers F - H. Experimentally has been demonstrated that the same type of glasses, exposed to radiation non ionizing of the type UV of around 230 nm, they produce defects similar Frenkel. The situation is interesting all time that photons of 230 nm (5.3 eV) they cannot create excitons directly since they are in an energy level of approximately 2.4 inferior eV to the necessary energy for the production of the same ones. In order to investigating the type of process of creation of defects with UV light energy below the energy of the band prohibited in polluted alkaline halogenides with Eu{sup 2+}, mainly looking for experimental information that allows to explain the creation of defects taken place by the radiation non ionizing, one carries out the present work. It was found that, independently of the energy of the radiation used for the excitement, the emission comes from the transition 4f{sup 6}5d(t{sub 2g})-4f{sup 7}({sup 8}S{sub 7/2}) of the ion Eu{sup 2+} characterized by a wide band centered in 420 nm and an additional component in 460 nm of possibly intrinsic origin. It was determined that so much the F centers and F{sub z} participate in the thermoluminescent processes and of optically stimulated luminescence, achieving to identify those peaks of Tl strictly associated to the F centers (peak in 470 K for the KCl: Eu{sup 2+}) and F{sub z} (peak in 370 K). Also, by means of a process of selective photo stimulation evidence was obtained that the F center (peak in 470 K) is directly involved in the process of optically stimulated luminescence. Finally, the results point out that the existence of an exciton type process is more feasible of being observed in materials where the quantum efficiency of the auto trapped exciton emission is significantly bigger to that of the materials studied. (Author)

  18. Magnitud del enfisema inducido por elastasa: Posible relación con el tipo de daño agudo pulmonar Elastase induced emphysema: Possible relationship with the type of acute lung injury

    Directory of Open Access Journals (Sweden)

    ANDREA VECCHIOLA C

    2009-01-01

    Full Text Available Introducción: El modelo de instilación intratraqueal de elastasa induce daño alveolar difuso y destrucción de la matriz extracelular con desarrollo de enfisema. Sin embargo, el hámster Syrian Golden desarrolla enfisema más severo que el de la rata Sprague-Dawley. Si bien se sabe que los eventos tempranos después de la instilación de elastasa determinan la magnitud del enfisema, se desconoce si existen diferencias entre especies en la respuesta pulmonar temprana. Objetivo: Evaluar si existen diferencias entre ratas y hamsters en la respuesta pulmonar inicial después de la elastasa, mediante el uso de marcadores bioquímicos de daño pulmonar agudo. Resultados: Mientras la rata experimenta un gran aumento de permeabilidad alvéolo-capilar y pocos fenómenos hemorrágicos, el hamster presenta abundante hemorragia y escaso aumento de la permeabilidad. Conclusiones: Existen diferencias entre ratas y hamsters en la respuesta pulmonar inicial frente a la elastasa, que podrían tener relación con las diferencias en magnitud del enfisema.Introduction: Intratracheal instillation of elastase induces diffuse alveolar damage and emphysema development. However, the Syrian Golden hamster develops more severe emphysema than the Sprague-Dawley rat. Although it is known that early events after elastase instillation determine the magnitude of emphysema development, it is not known if there are species differences in the initial pattern of lung response to elastase. Objective: To evaluate whether rats and hamster differ in the early lung response to elastase, using biochemical markers of acute lung injury. Results: Whereas the rat shows a large increase in alveolar-capillary permeability and few hemorrhagic changes, the hamster shows significant amount of hemorrhage and a small increase in alveolar capillary permeability. Conclusions: There are differences between rats and hamsters in the initial lung response to elastase that could influence the magnitude of emphysema development.

  19. Action of the chlorophyllin (CHLN) on the double breaking induced by gamma radiation in germinal cells of Drosophila melanogaster; Accion de la clorofilina (CHLN) sobre los dobles rompimientos inducidos por radiacion gamma en celulas germinales de Drosophila melanogaster

    Energy Technology Data Exchange (ETDEWEB)

    Moreno M, A

    2005-07-01

    The chlorophyllin (CHLN) is a derived of the chlorophyll in the one which the atom of Mg is replaced by Cu. It has been broadly used as preservative in those foods, and in the treatment of geriatric patients. The results using different test systems have demonstrated that the CHLN reduces the DNA damage caused by different physical agents or chemical of direct action or insinuation. Another of the properties of the CHLN is it anti carcinogenic action, because it has been that inhibits the carcinogen activity of B1 (AFB1) aflatoxin and it diminishes the incidence of tumors caused for 2-amine-3-methylimidazo [4- 5f] quinoline (IQ) and it inhibits the development of colon cancer during the post-initiation phase. Recently the reports of the activity promoter of the CHLN have been increased on the genetic damage. This effect observed in Salmonella and later on in Drosophila melanogaster using, physical and chemical agents. Presently study determines the action of the CHLN before the genetic effect induced in germinal cells of Drosophila melanogaster by means of the test of the lost one of the X chromosome in ring using two protocols; the first one consisted on pretreatment with CHLN to the male ones and later on to irradiate them and in the second protocol the pretreatment with CHLN administers to the females, in both protocols its were used a litter systems. (Author)

  20. Daño renal en ratas inducido por veneno de Bothrops neuwiedii diporus de Argentina Renal injury in rats poisoned by venom of Bothrops neuwiedii diporus from Argentina

    Directory of Open Access Journals (Sweden)

    Patricia Koscinczuk

    2004-08-01

    Full Text Available La insuficiencia renal aguda es una de las complicaciones sistémicas más frecuentes después de un accidente ofídico. En este estudio se evalúan los efectos que el veneno de Bothrops neuwiedii diporus produce en el riñón de ratas machos de la cepa Wistar. La histopatología permitió comprobar el desarrollo de necrosis tubular aguda; las lesiones iniciales se observaron a las 3 horas de la inoculación de una dosis de 700 µg del veneno, observándose en corteza renal congestión y degeneración granulohialina de las células epiteliales tubulares, acompañadas de dilatación y cilindros hialinos en la luz tubular. A las 24 horas se presentó necrosis tubular aguda en una superficie extensa de la corteza sin daño de la membrana basal tubular. Las lesiones de degeneración turbia de células epiteliales tubulares, dilatación de la luz tubular y cilindros hialinos se mantuvieron presentes hasta las 4 semanas post-inoculación. Si bien los parámetros de la bioquímica clínica asociados con insuficiencia renal aguda aumentaron a las 6 horas de la administración del veneno (urea: 1.10±0.22 g/dl; creatinina: 19.60±1.51mg/dl, a la semana descendieron a valores normales. Las densidades urinarias, en cambio, a la semana se mantuvieron más bajas que lo normal, 1.005 ± 0.001 (pAcute renal failure is one of the systemic complications that can be found in bothropic accidents. In this study the effects on male Wistar rats induced by the venom of Bothrops neuwiedii diporus were evaluated. The histopathology revealed acute tubular necrosis, lesions firstly were observed 3 hours post inoculation of 700 µg of venom. Cortical kidney congestion and granulohialin degeneration of tubular epithelial cells were observed, these lesions achieved a maximum at 24 hours after inoculation. Tubular epithelial hidropic degeneration and dilatation of tubular lumen with hyalin casts were present inclusive up to 4 weeks after inoculation. Biochemical parameter values associated with kidney renal failure were increased 6 hours after venom inoculation (urea: 1.10± 0.22 g/dl; creatinine: 19.60±1.51 mg/dl, but at the end of the first week they decreased till normal values. The urinary density was lower than normal value: 1.005±0.001 (p<0.001 and at the end of the first month they oscillated between 1.005 and 1.060 (p<0.001. Renal injury induced by B. neuwiedii diporus could be better appreciated by histopathology than by the routine laboratory assays.

  1. Action of the chlorophyllin before genetic damage induced by gamma radiation in germinal cells of Drosophila; Accion de la clorofilina ante el dano genetico inducido por radiacion gamma en celulas germinales de Drosophila

    Energy Technology Data Exchange (ETDEWEB)

    Moreno B, R

    2004-07-01

    The chlorophyllin (CHLN) is a porphyrin of nutritious grade and soluble in water, derived of the chlorophyll. It has been reported that this pigment is a good anti mutagen since it reduces the damage to the DNA caused by physical or chemical agents of direct or indirect action. Their anti carcinogenic action has also been demonstrated when it is administered itself during the induced post-initiation phase by aflatoxins and heterocyclic amines. However in the last decade it has been reported that it also has promoter activity against the genetic damage induced by diverse agents like the alkyl ants of direct and indirect action, the gamma radiation and some heterocyclic amines. This effect has been observed in testing systems like Salmonella, Drosophila, rainbow trout and rodents. In the mouse spermatogonia it has been reported that it reduces the damage to the DNA but with the test of lethal dominant in Drosophila increment the damage induced by gamma radiation. The present study consisted on evaluating the effect of the CHLN in the line germinal masculine of Drosophila by means of the lethal recessive test bound to the sex (LRLS) with the stump Muller 5 and a litters system. Its were pretreated wild males with CHLN and 24 h later were irradiated with 0, 10, 20 and 40 Gy of gamma radiation immediately later were crossed with virgin females of the stump Basc and at 72 h the male was transferred to a cultivation media with three new virgin females, this process repeated three times until completing 3 litters. The F1 it was crossed among itself and in the F2 it was analysed the presence or absence of lethals. The results indicated that the CHLN per se incremented the basal frequency of damage due to the pigment can act as an agent that is inserted to the ADN causing pre mutagenic leisure. Nevertheless with the groups treated with the different doses of gamma radiation the CHLN does not present any protector action, neither promoter except in the litter I of the group treated with 20 Gy where it was observed a promoter effect of genetic damage. (Author)

  2. Twenty-five years of study of the atmospheric contamination by means of proton-induced X-ray emission analysis; Veinticinco anos de estudio de la contaminacion atmosferica mediante microanalisis de rayos X inducidos por particula (PIXE)

    Energy Technology Data Exchange (ETDEWEB)

    Aldape U, F.; Flores M, J., E-mail: francisca.aldape@inin.gob.m [ININ, Departamento de Estudios del Ambiente, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-07-01

    At the present time, the microanalysis technique PIXE is accepted by the scientific community as one of the basic techniques used in the study of airborne particle matter, due to the multiple qualities that this offers for the study of this type of pollutants. The nuclear techniques have important applications in the study and technology of solid materials, archaeology and biomedical studies, and particularly in the study of the particles suspended in the air where the PIXE technique is more used because provides reliable results for the identification and quantification of chemical elements from the aluminum until the uranium, including all the metallic elements. Among the main reasons that have motivated the study of the particles suspended in the air is the fact that these cause effects in the human health. At the moment, the sanitary problems associated to the particles are a reason of great concern in many countries where in very populated cities the total of particles in suspension often surpasses the limits settled down by the World Organization of the Health. (Author)

  3. Celulitis por citomegalovirus

    Directory of Open Access Journals (Sweden)

    A. Ruiz Lascano

    2002-12-01

    Full Text Available Las lesiones cutáneas por citomegalovirus (CMV son infrecuentes y a menudo una manifestación tardía de una enfermedad sistémica, que generalmente anuncia un curso fatal. Comunicamos un caso de celulitis por CMV: una mujer de 70 años con trasplante renal efectuado 1 mes antes de la consulta, terapia inmunosupresora con ciclosporina A y metilprednisona. La paciente ingresó por fiebre, dolor e impotencia funcional en pierna derecha. Comprobamos la existencia de una placa de 8 por 4 cm eritematoedematosa. La tratamos con antibióticos sin mejoría, por lo que realizamos un estudio histopatológico de piel que mostró cambios citopáticos compatibles con infección por CMV. Los cultivos bacteriológicos y micológicos fueron negativos. La inmunohistoquímica específica para CMV y el estudio de reacción en cadena de la polimerasa (PCR de la biopsia de piel fueron positivas, al igual que la antigenemia. El tratamiento con ganciclovir produjo la mejoría del cuadro clínico. En la literatura revisada no hemos encontrado la celulitis como manifestación de enfermedad cutánea por CMV.

  4. Fatores associados ao aborto induzido entre jovens pobres na cidade de São Paulo, 2007 Factores asociados al aborto inducido entre jóvenes pobres en la ciudad de Sao Paulo, 2007 Factors associated with induced abortion among poor youth in the city of São Paulo, 2007

    Directory of Open Access Journals (Sweden)

    Rebeca de Souza e Silva

    2012-12-01

    Full Text Available Esse artigo investiga fatores associados ao aborto induzido entre jovens residentes numa comunidade pobre da cidade de São Paulo. A amostra foi composta por 102 homens e 99 mulheres de 14 a 25 anos de idade que já haviam iniciado suas vidas sexuais. Usou-se o modelo hierárquico de regressão logística. As variáveis não ter companheiro sexual no momento da entrevista, sexo do entrevistado, idade no momento da entrevista, priorizar morar só e número de gestações compuseram o modelo final. Dar muita importância a morar só quadruplica a chance de ocorrer um aborto. Jovens mais velhos foram menos propensos a se deparar com um aborto, dado que a chance de se optar pelo aborto se reduz 17% para cada incremento de um ano na idade dos jovens. Isso é indicativo de que as gestações ocorreram de forma inesperada, intempestiva, como é praxe nas condutas adolescentes, sendo as maiores candidatas a terminarem em aborto provocado. Evidencia-se, portanto, a necessidade de serem investidos recursos financeiros para obtenção de métodos contraceptivos eficazes e inócuos, destinados ao início da vida sexual.Este artículo investiga factores asociados al aborto inducido entre jóvenes residentes en una comunidad pobre de la ciudad de Sao Paulo. La muestra estaba compuesta por 102 hombres y 99 mujeres de 14 a 25 años de edad que ya habían dado inicio a sus vidas sexuales. Se usó el modelo jerárquico de regresión logística. Las variables: no tener compañero sexual en el momento de la entrevista, sexo del entrevistado, edad en el momento de la entrevista, priorizar vivir solo, y número de gestaciones, compusieron el modelo final. Dar mucha importancia a vivir solo cuadruplica la posibilidad de que se produzca un aborto. Jóvenes de mayor edad fueron menos propensos a encontrarse con un aborto, dado que la posibilidad de optar por un aborto se reduce un 17%, respectoa cada incremento de un año en la edad de los jóvenes. Eso es indicativo de

  5. New ALPHA-2 magnet

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    On 21 June, members of the ALPHA collaboration celebrated the handover of the first solenoid designed for the ALPHA-2 experiment. The magnet has since been successfully installed and is working well.   Khalid Mansoor, Sumera Yamin and Jeffrey Hangst in front of the new ALPHA-2 solenoid. “This was the first of three identical solenoids that will be installed between now and September, as the rest of the ALPHA-2 device is installed and commissioned,” explains ALPHA spokesperson Jeffrey Hangst. “These magnets are designed to allow us to transfer particles - antiprotons, electrons and positrons - between various parts of the new ALPHA-2 device by controlling the transverse size of the particle bunch that is being transferred.” Sumera Yamin and Khalid Mansoor, two Pakistani scientists from the National Centre for Physics in Islamabad, came to CERN in February specifically to design and manufacture these magnets. “We had the chance to work on act...

  6. Alpha Shapes and Proteins

    DEFF Research Database (Denmark)

    Winter, Pawel; Sterner, Henrik; Sterner, Peter

    2009-01-01

    We provide a unified description of (weighted) alpha shapes, beta shapes and the corresponding simplicialcomplexes. We discuss their applicability to various protein-related problems. We also discuss filtrations of alpha shapes and touch upon related persistence issues.We claim that the full...... potential of alpha-shapes and related geometrical constructs in protein-related problems yet remains to be realized and verified. We suggest parallel algorithms for (weighted) alpha shapes, and we argue that future use of filtrations and kinetic variants for larger proteins will need such implementation....

  7. Study of the excited levels of 233{sup P}a by the 237{sup N}p alpha decay; Estudio de los niveles excitados en el 233{sup P}a por la desintegracion alfa del 237{sup N}p

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, J.; Gaeta, R.; Vano, E.; Los Arcos, J. M.

    1978-07-01

    The excited levels in 233{sup P}a following the 237{sup N}p alpha decay have been studied, by performing different experiences to complete available data and supply new information. Thus, two direct alpha spectrum measurement, one alpha-gamma bidimensional coincidence experiment, three gamma-gamma and gamma-X ray coincidences and some other measurements of the gamma spectrum, direct and coincident with alpha-particles have been made. These last experiences have allowed to obviate usual radiochemical separation methods, the 233{sup P}a radioactive descendent interferences being eliminated by means of the coincidence technic. As a result, a primary decay scheme has been elaborated, including 15 new gamma transitions and two new levels, not observed in the most recent works. (Author) 60 refs.

  8. Targeted Alpha Therapy: From Alpha to Omega

    International Nuclear Information System (INIS)

    This review covers the broad spectrum of Targeted Alpha Therapy (TAT) research in Australia; from in vitro and in vivo studies to clinical trials. The principle of tumour anti-vascular alpha therapy (TAVAT) is discussed in terms of its validation by Monte Carlo calculations of vascular models and the potential role of biological dosimetry is examined. Summmary of this review is as follows: 1. The essence of TAT 2. Therapeutic objectives 3. TAVAT and Monte Carlo microdosimetry 4. Biological dosimetry 5. Preclinical studies 6. Clinical trials 7. What next? 8. Obstacles. (author)

  9. Buffett’s Alpha

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Kabiller, David; Heje Pedersen, Lasse

    Berkshire Hathaway has realized a Sharpe ratio of 0.76, higher than any other stock or mutual fund with a history of more than 30 years, and Berkshire has a significant alpha to traditional risk factors. However, we find that the alpha becomes insignificant when controlling for exposures to Betting...

  10. Alpha-particle diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Young, K.M.

    1991-01-01

    This paper will focus on the state of development of diagnostics which are expected to provide the information needed for {alpha}- physics studies in the future. Conventional measurement of detailed temporal and spatial profiles of background plasma properties in DT will be essential for such aspects as determining heating effectiveness, shaping of the plasma profiles and effects of MHD, but will not be addressed here. This paper will address (1) the measurement of the neutron source, and hence {alpha}-particle birth profile, (2) measurement of the escaping {alpha}-particles and (3) measurement of the confined {alpha}-particles over their full energy range. There will also be a brief discussion of (4) the concerns about instabilities being generated by {alpha}-particles and the methods necessary for measuring these effects. 51 refs., 10 figs.

  11. Imaging alpha particle detector

    Science.gov (United States)

    Anderson, D.F.

    1980-10-29

    A method and apparatus for detecting and imaging alpha particles sources is described. A dielectric coated high voltage electrode and a tungsten wire grid constitute a diode configuration discharge generator for electrons dislodged from atoms or molecules located in between these electrodes when struck by alpha particles from a source to be quantitatively or qualitatively analyzed. A thin polyester film window allows the alpha particles to pass into the gas enclosure and the combination of the glass electrode, grid and window is light transparent such that the details of the source which is imaged with high resolution and sensitivity by the sparks produced can be observed visually as well. The source can be viewed directly, electronically counted or integrated over time using photographic methods. A significant increase in sensitivity over other alpha particle detectors is observed, and the device has very low sensitivity to gamma or beta emissions which might otherwise appear as noise on the alpha particle signal.

  12. Neutrophil predominance in induced sputum from asthmatic patients: Therapeutic implications and role of clara cell 16-KD protein Predominio de neutrófilos en esputo inducido de asmáticos: Implicancias terapéuticas y rol de la proteína 16-kD de la célula clara

    Directory of Open Access Journals (Sweden)

    Elisa M. Uribe Echevarría

    2011-08-01

    ísticas clínico-funcionales, el patrón celular y las moléculas solubles del esputo inducido, para guiar el tratamiento apropiado anti-inflamatorio. Se incluyeron 41 pacientes: 21 a 40 años de edad, con asma estable leve a grave, no tratados con esteroides tópicos ni sistémicos y no fumadores. Se obtuvo una muestra de esputo inducido en condiciones basales, una segunda muestra después del tratamiento al azar con budesonida (400 µg dos veces al día o el montelukast (10 mg/d durante seis semanas, y una final después de un período de lavado de 4 semanas. En el frotis por citocentrifugado se evaluó el predominio de eosinófilos (EP o neutrófilos (NP, y en el sobrenadante se determinó LTE4, y CC16. Se midió la variabilidad del flujo espiratorio máximo (PEFV. Un total de 23/41 pacientes correspondieron al EP y 18/41 pacientes con NP. El PEFV fue mayor en el EP que en NP. LTE4 fue mayor en NP que en EP. No se encontraron diferencias de los niveles de CC16 en ambos grupos. Montelukast redujo la célula predominante en ambos subgrupos, mientras que budesonida sólo redujo los eosinófilos en EP. Tanto budesonida como montelukast redujeron PEFV en EP, pero no en NP. El nivel de CC16 aumentó significativamente en el EP luego del tratamiento antiinflamatorio. En conclusión: se identificó un subgrupo de asmáticos NP que presentan una menor labilidad bronquial, la vía de los leucotrienos parece estar involucrada y responde al tratamiento anti-leucotrienos. Este fenotipo muestra una escasa recuperación del nivel de CC16 posterior al tratamiento.

  13. Efectos del extracto de semillas de uva sobre la cistopatia diabética inducida por estreptozotocina en ratas

    Directory of Open Access Journals (Sweden)

    María Lourdes Arruzazabala

    2010-01-01

    aisladas de vejiga de rata, pero impidió completamente el aumento de las concentraciones séricas de creatinina inducido por STZ.

  14. The alpha channeling effect

    Energy Technology Data Exchange (ETDEWEB)

    Fisch, N. J.

    2015-12-10

    Alpha particles born through fusion reactions in a tokamak reactor tend to slow down on electrons, but that could take up to hundreds of milliseconds. Before that happens, the energy in these alpha particles can destabilize on collisionless timescales toroidal Alfven modes and other waves, in a way deleterious to energy confinement. However, it has been speculated that this energy might be instead be channeled into useful energy, so as to heat fuel ions or to drive current. Such a channeling needs to be catalyzed by waves Waves can produce diffusion in energy of the alpha particles in a way that is strictly coupled to diffusion in space. If these diffusion paths in energy-position space point from high energy in the center to low energy on the periphery, then alpha particles will be cooled while forced to the periphery. The energy from the alpha particles is absorbed by the wave. The amplified wave can then heat ions or drive current. This process or paradigm for extracting alpha particle energy collisionlessly has been called alpha channeling. While the effect is speculative, the upside potential for economical fusion is immense. The paradigm also operates more generally in other contexts of magnetically confined plasma.

  15. Efectos tóxicos producidos por las microcistinas en peces

    Directory of Open Access Journals (Sweden)

    AI Prieto

    2008-01-01

    Full Text Available Las microcistinas (MC son toxinas peptídicas producidas, generalmente en medios acuáticos eutróficos, por distintos géneros de cianobacterias, destacando como una de las principales especies productoras Microcystis aeruginosa. Estructuralmente, las MC son heptapéptidos cíclicos y funcionalmente están clasificadas dentro del grupo de las hepatotoxinas. Las MC han originado intoxicaciones a veces incluso fatales tanto en animales como en humanos, por lo que están consideradas como un problema ambiental, ecotoxicológico y principalmente sanitario, destacando su posible actividad carcinógenica. Se ha establecido una Ingesta Diaria Tolerable (IDT provisional de 0,04 µg/Kg/día de equivalentes de MC-LR y en relación con este valor guía, se considera que la exposición a MC por consumo de alimentos puede ser del orden del 20%, una vez reconocida su bioacumulación en algunos tejidos de plantas, moluscos y pescados, ya que las cianobacterias son un importante componente de la dieta de muchos peces cíclidos tropicales y ciprínidos. Son diversos los estudios de campo que demuestran la acumulación de MC en pescados, procedentes de lagos con floraciones de cianobacterias tóxicas, incluso en periodos de baja densidad fitoplanctónica, pudiéndose alcanzar valores muy próximos a la IDT anteriormente mencionada. Al ser los peces uno de los organismos más proclives a las intoxicaciones por MC y acumularlas, en los últimos años se ha constatado un aumento considerable de las publicaciones científicas sobre los daños fisiopatológicos inducidos por las mismas a nivel macroscópico, histológico, ultraestructural y metabólico en peces, en función de la especie piscícola, lo que justifica su revisión

  16. Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia La mifepristona inhibe el crecimiento de carcinomas mamarios inducidos por MPA o por FGF2 pero no las hiperplasias mamarias inducidas por FGF2

    OpenAIRE

    Cerliani, Juan P.; Sebastián Giulianelli; Ana Sahores; Victoria Wargon; Adrián Gongora; Alberto Baldi; Alfredo Molinolo; Lamb, Caroline A.; Claudia Lanari

    2010-01-01

    We have previously demonstrated a crosstalk between fibroblast growth factor 2 (FGF2) and progestins inducing experimental breast cancer growth. The aim of the present study was to compare the effects of FGF2 and of medroxyprogesterone acetate (MPA) on the mouse mammary glands and to investigate whether the antiprogestin RU486 was able to reverse the MPA- or FGF2-induced effects on both, mammary gland and tumor growth. We demonstrate that FGF2 administered locally induced an intraductal hyper...

  17. Local versus nonlocal $\\alpha\\alpha$ interactions in $3\\alpha$ description of $^{12}$C

    CERN Document Server

    Suzuki, Y; Descouvemont, P; Fujiwara, Y; Matsumura, H; Orabi, M; Theeten, M

    2008-01-01

    Local $\\alpha \\alpha$ potentials fail to describe $^{12}$C as a $3\\alpha$ system. Nonlocal $\\alpha \\alpha$ potentials that renormalize the energy-dependent kernel of the resonating group method allow interpreting simultaneously the ground state and $0^+_2$ resonance of $^{12}$C as $3\\alpha$ states. A comparison with fully microscopic calculations provides a measure of the importance of three-cluster exchanges in those states.

  18. Bremsstrahlung in $\\alpha$ Decay

    CERN Document Server

    Takigawa, N; Hagino, K; Ono, A; Brink, D M

    1999-01-01

    A quantum mechanical analysis of the bremsstrahlung in $\\alpha$ decay of $^{210}$Po is performed in close reference to a semiclassical theory. We clarify the contribution from the tunneling, mixed, outside barrier regions and from the wall of the inner potential well to the final spectral distribution, and discuss their interplay. We also comment on the validity of semiclassical calculations, and the possibility to eliminate the ambiguity in the nuclear potential between the alpha particle and daughter nucleus using the bremsstrahlung spectrum.

  19. Osteomielitis por salmonella

    Directory of Open Access Journals (Sweden)

    Alicia Velázquez Pérez

    2014-08-01

    Full Text Available Se presenta el caso de una paciente femenina de color blanco y dos años de edad, con diagnóstico prenatal de sicklemia, que desde edades tempranas tiene problemas de la enfermedad. Ingresó en esta ocasión por una de las complicaciones infecciosas que ocasiona este padecimiento, una osteomielitis del húmero izquierdo, aislándose el germen en el hemocultivo realizado, una salmonella. Necesitó de tratamiento enérgico y prolongado; se obtuvo un resultado satisfactorio en la evolución de la enfermedad y se sigue sistemáticamente por consulta externa en la actualidad

  20. Dermatitis canina por Malassezia

    Directory of Open Access Journals (Sweden)

    Rejas López, Juan

    2008-05-01

    Full Text Available La dermatitis por Malassezia en perros en generalmente una complicación a procesos alérgicos, seborreicos, presencia de pliegues, etc. aunque también se han descrito otras presentaciones, como la hipersensibilidad contra esta levadura. La demostración de la presencia de Malassesia pachydermatis se hace de manera sencilla mediante citología. El tratamiento de esta dermatitis puede ser tópico u oral.

  1. Dermatitis canina por Malassezia

    OpenAIRE

    Rejas López, Juan

    2008-01-01

    La dermatitis por Malassezia en perros en generalmente una complicación a procesos alérgicos, seborreicos, presencia de pliegues, etc. aunque también se han descrito otras presentaciones, como la hipersensibilidad contra esta levadura. La demostración de la presencia de Malassesia pachydermatis se hace de manera sencilla mediante citología. El tratamiento de esta dermatitis puede ser tópico u oral.

  2. ALPHA-2: the sequel

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    While many experiments are methodically planning for intense works over the long shutdown, there is one experiment that is already working at full steam: ALPHA-2. Its final components arrived last month and will completely replace the previous ALPHA set-up. Unlike its predecessor, this next generation experiment has been specifically designed to measure the properties of antimatter.   The ALPHA team lower the new superconducting solenoid magnet into place. The ALPHA collaboration is working at full speed to complete the ALPHA-2 set-up for mid-November – this will give them a few weeks of running before the AD shutdown on 17 December. “We really want to get some experience with this device this year so that, if we need to make any changes, we will have time during the long shutdown in which to make them,” says Jeffrey Hangst, ALPHA spokesperson. “Rather than starting the 2014 run in the commissioning stage, we will be up and running from the get go.&...

  3. causada por Fusarium moniliforme

    Directory of Open Access Journals (Sweden)

    Mariano Mendoza Elos

    2006-01-01

    Full Text Available El objetivo de éste trabajo fue determinar la resistencia horizontal de 134 líneas S1 de maíz al hongo Fusarium moniliforme. La enfermedad fue inducida mediante inoculación en la etapa de floración masculina bajo condiciones de campo utilizando la técnica del palillo. Las líneas se evaluaron en México en 2002. La estimación de la enfermedad se hizo en dos ocasiones con una separación de 20 días. Las evaluaciones mostraron que las líneas Roque-801, 804, 1103 y 1405 fueron resistentes en la primera evaluación. Las tasas de incremento de la enfermedad variaron de 0,01 a 0,229 por unidad por día. Las líneas mostraron bajos niveles de enfermedad de 0 a 1 % en la primera evaluación. En la segunda evaluación, los niveles de enfermedad variaron de 49 a 100 %. En un programa de mejoramiento genético estas líneas pueden ser utilizadas para mejorar la resistencia horizontal del maíz a la pudrición del tallo causada por Fusarium moniliforme

  4. Efectividad de la ivermectina en un modelo de disquinesia tardía inducida por haloperidol en ratas

    Directory of Open Access Journals (Sweden)

    Mauricio Palacios

    2008-09-01

    Full Text Available Introducción: Los síntomas extrapiramidales y en especial las disquinesias tardías, son la mayor limitante de la terapia con antipsicóticos, debido a la frecuencia de aparición durante el tratamiento y la falta de recursos para controlar estas reacciones adversas, por lo cual es necesario investigar nuevos recursos para el manejo de las disquinesias tardías.Objetivo: Evaluar el efecto de la ivermectina sobre las disquinesias tardías inducidas por haloperidol en ratas.Métodos: En un modelo de dosis única de haloperidol con ratas Sprague Dawley, se evalúo la capacidad de la ivermectina para evitar cambios en la conducta motora y la aparición de movimientos anormales. Adicionalmente, se implementó un modelo animal crónico conocido como VCM (vacuous chewing movements, donde se evaluó la frecuencia de movimientos orofaciales durante seis meses, al recibir simultáneamente haloperidol e ivermectina a dosis diferentes, comparándolo con un grupo control y otro grupo al que se le administró haloperidol.Resultados: La ivermectina no evitó los cambios inducidos por haloperidol en el comportamiento motor, ni la aparición de movimientos anormales en el modelo agudo. Tampoco modificó la frecuencia de movimientos orofaciales en el modelo de administración crónica de haloperidol. La ivermectina no indujo cambios en la conducta motora, ni la aparición de movimientos anormales en los modelos agudo y crónico.Conclusiones: Los hallazgos de este trabajo descartan a la ivermectina como candidata para el manejo de las disquinesias tardías y no permite aportar argumentos a la hipótesis GABAérgica en la fisiopatología de las disquinesias tardías. Adicionalmente, la ivermectina no induce movimientos anormales.

  5. Resting alpha activity predicts learning ability in alpha neurofeedback

    OpenAIRE

    Wenya eNan; Feng eWan; Mang I eVai; Agostinho eRosa

    2014-01-01

    Individuals differ in their ability to learn how to regulate the alpha activity by neurofeedback. This study aimed to investigate whether the resting alpha activity is related to the learning ability of alpha enhancement in neurofeedback and could be used as a predictor. A total of 25 subjects performed 20 sessions of individualized alpha neurofeedback in order to learn how to enhance activity in the alpha frequency band. The learning ability was assessed by three indices respectively: the tr...

  6. Detección y estudio mediante Fluorescencia Inducida por Láser de radicales libres formados por Disociación Multifotónica Infrarroja

    Science.gov (United States)

    Santos, M.; Díaz, L.; Torresano, J. A.; Rubio, L.; Samoudi, B.

    Una de las principales aplicaciones actuales de los procesos de disociación multifotónica inducidos por radiación láser infrarroja (DMI) es la producción de radiales libres, con el fin de estudiar sus propiedades cinéticas y espectroscópicas. La disociación de moléculas poliatómicas en el IR con láseres de CO2 tiene lugar desde la superficie de energía molecular mas baja y conduce generalmente a la formación de fragmentos en el estado electrónico fundamental, con diversos grados de excitación vibracional. En el Grupo de Procesos Multifotónicos del Instituto de Estructura de la Materia del C.S.I.C. hemos puesto a punto la técnica de Fluorescencia Inducida por Láser (LIF) para la detección y análisis en tiempo real de los fragmentos producidos en la DMI inducida mediante uno o dos campos láseres de diferentes longitudes de onda. Objetivos de nuestro trabajo han sido el estudio de los canales de disociación mayoritarios y de las especies transitoria producidas, así como de la distribución de energía interna con que éstas son generadas. En particular hemos detectado mediante LIF las especies: C2, CF, CH, SiH2, CF2, CH2, SiHCl, y CF3 a partir de la disociación de, entre otras, las siguientes moléculas: C2H3Br, C3F6, C4H8Si, C2H5ClSi y CH5ClSi. En este trabajo presentamos algunos de los resultados obtenidos mediante el estudio por LIF de estos radicales: estudio temporal de la señal LIF obtenida con determinación de tiempos de vida, espectros de excitación y fluorescencia, temperaturas vibracionales de formación, variación de la intensidad LIF con el tiempo de retraso entre los láseres de disociación y prueba, etc.

  7. Alpha particles in fusion research

    International Nuclear Information System (INIS)

    This collection of 39 (mostly view graph) presentations addresses various aspects of alpha particle physics in thermonuclear fusion research, including energy balance and alpha particle losses, transport, the influence of alpha particles on plasma stability, helium ash, the transition to and sustainment of a burning fusion plasma, as well as alpha particle diagnostics. Refs, figs and tabs

  8. SÍNTESIS DE ÓXIDOS CONDUCTORES TRANSPARENTES DE ÓXIDO DE ZINC DOPADO CON ALUMINIO POR COPRECIPITACIÓN QUÍMICA

    Directory of Open Access Journals (Sweden)

    Silvia Maioco

    2013-01-01

    Full Text Available Los óxidos de zinc dopados con Al (AZO son promisorios reemplazantes de los óxidos de indio dopados con Sn (ITO pero sus películas delgadas muestran un amplio rango de propiedades fuertemente dependientes de las condiciones del proceso de deposición. Se examinan cerámicos de granulometría submicrométrica de óxido de zinc dopado con 1% de aluminio, preparados por coprecipitación en solución acuosa, a partir de Zn(NO32 y Al(NO33, sinterizados a 1200°C y subsecuentemente templados en atmósfera controlada de 10-16 atm de oxígeno, a 1000°C. La resistividad eléctrica disminuye en dos órdenes de magnitud en las primeras dos horas de templado y el coeficiente Seebeck cambia de -140 a -50 μV/K gradualmente en 8 h. Se concluye que el aumento de la movilidad domina sobre el de densidad de portadores, inducido por cambios de la estequiometria metal oxígeno.

  9. Miotoxicidade por organofosforados

    Directory of Open Access Journals (Sweden)

    Cavaliere Maria J.

    1996-01-01

    Full Text Available Os organofosforados são um grupo de compostos químicos amplamente utilizados em agropecuária como inseticidas, ocasionando intoxicações acidentais em animais e humanos, e mesmo sendo utilizados em tentativas de suicídio. A toxicidade desses produtos decorre sobretudo de insuficiência cárdio-respiratória por compromentimento do sistema nervoso autônomo. Sabe-se que alguns destes compostos induzem em animais de experimentação e em humanos, uma miopatia caracterizada por degeneração de células musculares, comprometendo sobretudo a musculatura respiratória. Baseado no fato de que este comprometimento contribui para a piora da função respiratória, propõe-se um protocolo de avaliação rotineira de miotoxicidade por compostos organofosforados, através de uma bateria mínima e suficiente de colorações e reações histoquímicas para quantificação da necrose muscular. Utilizaram-se como modelo experimental, grupos de ratos albinos (Wistar intoxicados com o organofosforado paraoxon, com e sem antídotos (atropina ou pralidoxima. Verificou-se nos grupos tratados com paraoxon e paraoxon mais atropina, necrose de fibras musculares no diafragma, que atingia em determinadas áreas até 15% das fibras. No grupo tratado com paraoxon mais pralidoxima, a necrose foi mínima, evidenciando o papel mioprotetor deste último antídoto.

  10. Por mil devaluados pesos

    Directory of Open Access Journals (Sweden)

    Annie Rodríguez Collázos

    2013-03-01

    Full Text Available El estudio de lo popular y lo urbano hasta ahora se ha centrado en el comportamiento y en algunas relaciones de los habitantes con su entorno. “Por mil devaluados pesos. Publicidad popular y urbana”, pretende explorar las formas de publicidad, dispersas en diferentes espacios populares y urbanos en Bogotá, identificando esquemas y formas características de sus propios códigos comunicativos; se centran en un objeto de estudio consistente en las estrategias publicitarias y los códigos comunicativos en los mensajes publicitarios populares en las subculturas de San Victorino, 7 de Agosto y Sanandresito de San José.

  11. ALPHA MIS: Reference manual

    Energy Technology Data Exchange (ETDEWEB)

    Lovin, J.K.; Haese, R.L.; Heatherly, R.D.; Hughes, S.E.; Ishee, J.S.; Pratt, S.M.; Smith, D.W.

    1992-02-01

    ALPHA is a powerful and versatile management information system (MIS) initiated and sponsored and by the Finance and Business Management Division of Oak Ridge National Laboratory, who maintain and develop it in concert with the Business Systems Division for its Information Center. A general-purpose MIS, ALPHA allows users to access System 1022 and System 1032 databases to obtain and manage information. From a personal computer or a data terminal, Energy Systems employees can use ALPHA to control their own report reprocessing. Using four general commands (Database, Select, Sort, and Report) they can (1) choose a mainframe database, (2) define subsets within it, (3) sequentially order a subset by one or more variables, and (4) generate a report with their own or a canned format.

  12. Ojo por ojo

    OpenAIRE

    Ramón del Llano Ibáñez

    2011-01-01

    Nuestro pan y café de la mañana se acompaña de noticias alrededor de ejecuciones, de fosas clandestinas, de batallas del ejército, de balaceras en las calles y civiles caídos por balas perdidas : la muerte acompaña nuestro desayuno. Las calaveras de azúcar del día de muertos hoy son calaveras reales y amargas : 40 000 muertos en cuatro años después que el Presidente Calderón declaró la guerra a los narcotraficantes. Se han apresado a varios e importantes miembros de los cárteles : pero han si...

  13. Sepsis por shigella flexneri

    Directory of Open Access Journals (Sweden)

    César Cabrera C

    2005-04-01

    Full Text Available Se presenta un caso raro de sepsis por Shigella flexneri en una paciente de 45 años de edad quien estando hospitalizada para el estudio de un tumor cerebral, requirió el uso de manitol y dosis altas de corticoides; luego de ello presenta deposiciones líquidas con moco y sangre, desarrolla síndrome de respuesta inflamatoria sistémica, luego se aísla Shigella flexneri en el hemocultivo; recibió tratamiento antibiótico con ciprofloxacina. Se describen las características del caso y se comenta de acuerdo con la revisión de literatura.

  14. Onicomicosis por hongos fuliginosos

    Directory of Open Access Journals (Sweden)

    Ingrid Salas-Campos

    2009-12-01

    Full Text Available Justificación y objetivo: Las infecciones de las uñas producidas por hongos son un problema de frecuente consulta dermatológica. Los dermatofitos son la mayor causa de estas infecciones, siendo Trichophyton rubrum el agente etiológico más importante. Sin embargo, los hongos no dermatofitos, tanto hialinos como fuliginosos, pueden ser también responsables de estos cuadros clínicos. Debido a que estos hongos tienden a ser resistentes a los antimicóticos comúnmente usados para tratar las onicomicosis, es que se hace indispensable que el clínico se asegure por medio de un examen de laboratorio de la etiología de la infección. Métodos: Se estudiaron tres casos de pacientes con lesiones en uñas, que acudieron al laboratorio de Micología Médica, Facultad de Microbiología, Universidad de Costa Rica. Se realizaron los análisis de rutina para aislamiento e identificación de hongos patógenos. Resultados: En los tres casos estudiados se observó al examen directo micelio fuliginoso. En uno de los casos se aisló e identificó Scytalidium dimidiatum, hongo que presenta resistencia a los antifúngicos utilizados para tratar onicomicosis. Conclusión. El reporte de hongos diferentes a los dermatofitos como agentes etiológicos de onicomicosis es importante para que el médico pueda elegir el tratamiento más recomendado para este tipo de infección.

  15. Motivado por cirujanos

    Directory of Open Access Journals (Sweden)

    Carlos Salazar-Vargas

    2010-12-01

    Full Text Available Comenzaba la década de los 60 y nuestro grupo nerviosamente iniciaba lecciones en los hospitales de San José. En aquellos años, el estudiante de medicina empezaba su contacto con pacientes, por lo menos 1 ó 2 años después de iniciada la carrera. El estudio del ser humano normal que ya habíamos concluido, continuaba con el del enfermo, y más adelante aprenderíamos el tratamiento. La enfermedad descrita en el libro, de pronto se convertía en un enfermo, y es a este quien hoy veíamos, cohibido pero inquisidor, en la cama de un hospital. Los profesores nos enseñaban a interrogar y a examinar a los pacientes, y cada gesto suyo, cada pregunta, cada maniobra, eran celosamente guardados en la memoria de los educandos. Con claridad percibíamos, aun a temprana edad, las diferencias entre los especialistas, y casi de manera involuntaria, cada quien iba tomando partido y escogía su futuro camino. Fue durante esos tempranos años, cuando mi vida se cruzó con la de 7 maravillosas personas y excelentes cirujanos, que marcaron para siempre mi destino y, sin quererlo ellos, me hicieron inclinarme por la cirugía. Dos eran serios y profundamente académicos: el Dr. Manuel Aguilar Bonilla y el Dr. Vesalio Guzmán Calleja; 3, decididos, incansables y muy hábiles: el Dr. Longino Soto Pacheco, el Dr. Claudio Orlich Carranza y el Dr. Carlos Prada Díaz, y 2, abordables, prácticos, joviales y amistosos: el Dr. Fernando Valverde Soley y el Dr. Randall Ferris Iglesias….

  16. The $\\alpha_S$ Dependence of Parton Distributions

    OpenAIRE

    Martin, A. D.; Stirling, W. J.; Roberts, R G

    1995-01-01

    We perform next-to-leading order global analyses of deep inelastic and related data for different fixed values of $\\alpha_S (M_Z^2)$. We present sets of parton distributions for six values of $\\alpha_S$ in the range 0.105 to 0.130. We display the $(x, Q^2)$ domains with the largest parton uncertainty and we discuss how forthcoming data may be able to improve the determination of the parton densities.

  17. Genetics Home Reference: alpha thalassemia

    Science.gov (United States)

    ... for Disease Control and Prevention Centre for Genetics Education (Australia) Cooley's Anemia Foundation: Fact sheet about alpha thalassemia Disease InfoSearch: Alpha-Thalassemia Genomics Education Programme (UK) Information Center for Sickle Cell and ...

  18. $\\alpha$-minimal Banach spaces

    CERN Document Server

    Rosendal, Christian

    2011-01-01

    A Banach space with a Schauder basis is said to be $\\alpha$-minimal for some countable ordinal $\\alpha$ if, for any two block subspaces, the Bourgain embeddability index of one into the other is at least $\\alpha$. We prove a dichotomy that characterises when a Banach space has an $\\alpha$-minimal subspace, which contributes to the ongoing project, initiated by W. T. Gowers, of classifying separable Banach spaces by identifying characteristic subspaces.

  19. Sociedad por Acciones Simplificada

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Arcila Salazar

    2009-06-01

    Full Text Available En Colombia, aspectos como la responsabilidad limitada; supresión de la llamada doctrina de ultra vires; duración ilimitada; eliminación de la regla, una acción, un voto; remedios al abuso de los derechos; posibilidad de eliminar prohibiciones a los administradores, libertad de establecer restricciones para la transferencia de acciones y la simplificación de los procedimientos de fusión; son inviables bajo nuestra legislación. Sin embargo, la Ley 1258 de 2008, ha incorporado al derecho societario colombiano un nuevo tipo societario híbrido, llamado “Sociedad por Acciones Simplificada”. Esta forma societaria híbrida se basa en un principio básico: garantizar amplia libertad a los empresarios en la estructuración de sus relaciones a través de disposiciones contractuales. La S.A.S. provee a los empresarios significativa flexibilidad contractual, a la vez que preserva beneficios como la limitación de la responsabilidad.

  20. Sociedad por Acciones Simplificada

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Arcila Salazar

    2009-07-01

    Full Text Available En Colombia, aspectos como la responsabilidad limitada; supresión de la llamada doctrina de ultra vires; duración ilimitada; eliminación de la regla, una acción, un voto; remedios al abuso de los derechos; posibilidad de eliminar prohibiciones a los administradores, libertad de establecer restricciones para la transferencia de acciones y la simplificación de los procedimientos de fusión; son inviables bajo nuestra legislación. Sin embargo, la Ley 1258 de 2008, ha incorporado al derecho societario colombiano un nuevo tipo societario híbrido, llamado “Sociedad por Acciones Simplificada”. Esta forma societaria híbrida se basa en un principio básico: garantizar amplia libertad a los empresarios en la estructuración de sus relaciones a través de disposiciones contractuales. La S.A.S. provee a los empresarios significativa flexibilidad contractual, a la vez que preserva beneficios como la limitación de la responsabilidad.

  1. Resting alpha activity predicts learning ability in alpha neurofeedback

    Directory of Open Access Journals (Sweden)

    Wenya eNan

    2014-07-01

    Full Text Available Individuals differ in their ability to learn how to regulate the alpha activity by neurofeedback. This study aimed to investigate whether the resting alpha activity is related to the learning ability of alpha enhancement in neurofeedback and could be used as a predictor. A total of 25 subjects performed 20 sessions of individualized alpha neurofeedback in order to learn how to enhance activity in the alpha frequency band. The learning ability was assessed by three indices respectively: the training parameter changes between two periods, within a short period and across the whole training time. It was found that the resting alpha amplitude measured before training had significant positive correlations with all learning indices and could be used as a predictor for the learning ability prediction. This finding would help the researchers in not only predicting the training efficacy in individuals but also gaining further insight into the mechanisms of alpha neurofeedback.

  2. Tolerancia al daño inducido bajo solicitaciones de contacto cíclicas en carburos cementados WC-Co//Tolerance induced damage under cyclic contact loading of WC-Co cemented carbides

    Directory of Open Access Journals (Sweden)

    David Coureaux‐Mustelier

    2014-01-01

    Full Text Available El comportamiento mecánico de los carburos cementados WC-Co ha sido estudiado en detalle teniendo en cuenta los defectos preexistentes del material (daño intrínseco. Sin embargo, la información sobre los efectos del daño inducido en servicio (daño extrínseco en la integridad estructural de estos materiales esescasa. En este contexto, en este trabajo se evalúa la influencia del daño extrínseco en la resistencia mecánica residual de dos calidades con microestructuras diferentes. Para ello, se emplea la técnica de indentación esférica como medio para generar daño de forma controlada. Los resultados muestran que al incrementar el tamaño de grano del carburo y el contenido de cobalto, la respuesta mecánica de carburos cementados frente al contacto esférico es cada vez más cuasi-plástica, bajo la aplicación de cargas tanto monotónicas como cíclicas, y en consecuencia el material muestra una mayor tolerancia al daño.Palabras claves: carburos cementados, indentación esférica, resistencia mecánica residual, tolerancia al daño._______________________________________________________________________________AbstractThe mechanical behavior of WC-Co cemented carbides has been studied in detail taking into account the pre-existing material (intrinsic damage defects. However, information on the effects of service-induced damage (extrinsic damage on the structural integrity of these materials is limited. In this context, in thispaper the influence of extrinsic damage on the residual strength of two grades with different microstructures is evaluated. With this purpose, a spherical indentation technique is employed as a means for generating a controlled damage. The results show that by increasing the grain size of the carbide and the cobalt content, the mechanical properties of cemented carbides compared to spherical contact isincreasingly quasi-plastic, under the application of both monotonic and cyclic loads, and consequently the

  3. Combining Alphas via Bounded Regression

    Directory of Open Access Journals (Sweden)

    Zura Kakushadze

    2015-11-01

    Full Text Available We give an explicit algorithm and source code for combining alpha streams via bounded regression. In practical applications, typically, there is insufficient history to compute a sample covariance matrix (SCM for a large number of alphas. To compute alpha allocation weights, one then resorts to (weighted regression over SCM principal components. Regression often produces alpha weights with insufficient diversification and/or skewed distribution against, e.g., turnover. This can be rectified by imposing bounds on alpha weights within the regression procedure. Bounded regression can also be applied to stock and other asset portfolio construction. We discuss illustrative examples.

  4. Orthopositronium lifetime. Analytic results in O ({alpha}) and O ({alpha}{sup 3} ln {alpha})

    Energy Technology Data Exchange (ETDEWEB)

    Kniehl, B.A.; Kotikov, A.V.; Veretin, O.L. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    2008-06-15

    We present the O({alpha}) and O({alpha}{sup 3}ln {alpha}) corrections to the total decay width of orthopositronium in closed analytic form, in terms of basic transcendental numbers, which can be evaluated numerically to arbitrary precision. (orig.)

  5. Aspectos sociodemográficos e reprodutivos do abortamento induzido de mulheres internadas em uma maternidade do Município da Serra, ES Aspectos socio demográficos y reproductivos del aborto inducido en mujeres internadas en una maternidad del municipio de Sierra, ES Socio demographic and reproductive aspects of the induced miscarriage of women hospitalized in a maternity hospital of serra, state of Espírito Santo

    Directory of Open Access Journals (Sweden)

    Priscilla Rocha Araujo Nader

    2008-12-01

    Full Text Available Objetivo: Comparar aspectos sociodemográficos e reprodutivos entre mulheres que induziram a interrupção da gestação e mulheres que levaram a gestação a termo, admitidas em uma maternidade pública. Métodos: Estudo caso-controle onde foram incluídas 21 mulheres que realizaram abortamento induzido e 83 que tiveram gestação a termo, no período de agosto de 2005 a janeiro de 2006. Resultados: Não houve diferença significativa na comparação entre as freqüências dos grupos em relação à idade, cor da pele, anos de estudo, religião, renda mensal, idade da menarca, idade da coitarca, idade da primeira gestação, número de gestações, intervalo entre a última e a penúltima gestação e o número de filhos vivos. O estado conjugal casada/em união estável [OR=0,241 (IC95% 0,061 0,951] e desejo pela gravidez [OR=0,168 (IC95% 0,042 0,669] mostraram-se associados à ocorrência de abortamento induzido como fatores de proteção. Conclusão: Para atenuar o problema do abortamento inseguro, deve-se investir na promoção da saúde reprodutiva incentivando o acesso à educação sexual e ao planejamento familiar.Objetivo: Comparar aspectos socio demográficos y reproductivos entre mujeres que indujeron la interrupción del embarazo y mujeres que concluyeron el embarazo y fueron admitidas en una maternidad pública. Métodos: Estudio caso-control donde fueron incluidas 21 mujeres que realizaron aborto inducido y 83 que tuvieron la gestión completa, en el período de agosto de 2005 a enero de 2006. Resultados: No hubo diferencia significativa en la comparación entre las frecuencias de los grupos en relación a la edad, color de piel, años de estudio, religión, renta mensual, edad de menopausia, edad de iniciación sexual, edad del primer embarazo, número de embarazos, intervalo entre el último y el penúltimo embarazo y el número de hijos vivos. El estado conyugal casado/a estable [OR=0,241 (IC95% 0,061 0,951] y deseo por el

  6. CHIRAL UNIVERSES AND QUANTUM EFFECTS PRODUCED BY ELECTROMAGNETIC FIELDS UNIVERSOS QUIRALES Y EFECTOS CUÁNTICOS PRODUCIDOS POR CAMPOS ELECTROMAGNÉTICOS

    Directory of Open Access Journals (Sweden)

    Héctor Torres-Silva

    2008-11-01

    Full Text Available The accepted structure of space and vacuum derives from the results of relativistic cosmology and quantum field theory. It is demonstrated that a chiral interface between enantiomeric regions of a closed universe, or a (right R-Universe and (left L-Universe, related by an element of PCT symmetry along the interface, represents a construct with all the attributes required of the theoretical vacuum, in-so-far as quantum behaviour is then seen to be induced by the vacuum interface. Quantum mechanics emerges as a special case of classical mechanics, rather than the latter being a subset of the former. This removes the quantum-mechanical observational problem, explains the cosmological large-number coincidences, and accounts for the anti-matter in the cosmos.La estructura aceptada del espacio y el vacío se derivan de los resultados de la cosmología relativística y de la teoría cuántica de campo. Se demuestra que una interfaz quiral entre regiones enantioméricas de un universo cerrado, o un universo derecho y un universo izquierdo, relacionados por un elemento de simetría PCT a lo largo de la interfaz, representa un modelo con todos los atributos requeridos por el vacío teórico. Se desprende que el comportamiento cuántico es entonces visto que es inducido por la interfaz de vacío. La mecánica quántica emerge como un caso especial de la mecánica clásica, más bien que siendo la última un subconjunto de la primera. Esto resuelve el problema observacional mecánico cuántico, explica las coincidencias de los grandes números cosmológicos y toma en cuenta la antimateria en el cosmos.

  7. Unfolding domains of recombinant fusion alpha alpha-tropomyosin.

    OpenAIRE

    Ishii, Y; Hitchcock-DeGregori, S.; Mabuchi, K; Lehrer, S S

    1992-01-01

    The thermal unfolding of the coiled-coil alpha-helix of recombinant alpha alpha-tropomyosin from rat striated muscle containing an additional 80-residue peptide of influenza virus NS1 protein at the N-terminus (fusion-tropomyosin) was studied with circular dichroism and fluorescence techniques. Fusion-tropomyosin unfolded in four cooperative transitions: (1) a pretransition starting at 35 degrees C involving the middle of the molecule; (2) a major transition at 46 degrees C involving no more ...

  8. Alpha-mannosidosis

    Directory of Open Access Journals (Sweden)

    Nilssen Øivind

    2008-07-01

    Full Text Available Abstract Alpha-mannosidosis is an inherited lysosomal storage disorder characterized by immune deficiency, facial and skeletal abnormalities, hearing impairment, and intellectual disability. It occurs in approximately 1 of 500,000 live births. The children are often born apparently normal, and their condition worsens progressively. Some children are born with ankle equinus or develop hydrocephalus in the first year of life. Main features are immune deficiency (manifested by recurrent infections, especially in the first decade of life, skeletal abnormalities (mild-to-moderate dysostosis multiplex, scoliosis and deformation of the sternum, hearing impairment (moderate-to-severe sensorineural hearing loss, gradual impairment of mental functions and speech, and often, periods of psychosis. Associated motor function disturbances include muscular weakness, joint abnormalities and ataxia. The facial trait include large head with prominent forehead, rounded eyebrows, flattened nasal bridge, macroglossia, widely spaced teeth, and prognathism. Slight strabismus is common. The clinical variability is significant, representing a continuum in severity. The disorder is caused by lysosomal alpha-mannosidase deficiency. Alpha-mannosidosis is inherited in an autosomal recessive fashion and is caused by mutations in the MAN2B1 gene located on chromosome 19 (19 p13.2-q12. Diagnosis is made by measuring acid alpha-mannosidase activity in leukocytes or other nucleated cells and can be confirmed by genetic testing. Elevated urinary secretion of mannose-rich oligosaccharides is suggestive, but not diagnostic. Differential diagnoses are mainly the other lysosomal storage diseases like the mucopolysaccharidoses. Genetic counseling should be given to explain the nature of the disease and to detect carriers. Antenatal diagnosis is possible, based on both biochemical and genetic methods. The management should be pro-active, preventing complications and treating

  9. Por que sou rondoniano

    Directory of Open Access Journals (Sweden)

    Mércio Pereira Gomes

    2009-01-01

    Full Text Available Numa revisão contextualizada no tempo e projetada pelos seus resultados, a obra do sertanista marechal Cândido Rondon (1867-1958 é avaliada positivamente pela dedicação à causa dos povos indígenas do Brasil, pela formação de uma ética de respeito do brasileiro para com os índios e pela institucionalização do dever do Estado brasileiro de proteger, assistir e ajudar os povos indígenas a manterem-se coesos e autônomos e ao mesmo tempo se projetarem no mundo mais amplo. A vida de Rondon é acompanhada desde a sua formação como cadete da Escola Militar, como membro da Igreja do Apostolado Positivista, como comandante da Expedição Rondon (1907-1930, que levou o telégrafo de Cuiabá a Porto Velho, e especialmente como criador e dirigente-mor do Serviço de Proteção aos Índios (SPI, 1910-1967. Rondon é o criador da expressão "Morrer se preciso for, matar nunca", que pautou a ação de indigenistas brasileiros que fizeram os primeiros contatos com muitos povos indígenas desde 1910. E muitos morreram seguindo essa norma, numa clara demonstração do novo espírito humanista criado pela atitude rondoniana. O indigenismo brasileiro implantado por Rondon teve altos e baixos ao longo de quase cem anos, que hoje prossegue pela Fundação Nacional do Índio (Funai. De fato, muitos povos indígenas perderam suas terras e muitos foram dizimados no século XX, mas os mais de 220 que sobreviveram vêm crescendo em número, obtendo suas terras (13% do território nacional e conquistando novos espaços político-culturais no Brasil.This paper reviews the life and work of Brazilian Indianist Marshall Cândido Rondon. Rondon's life is marked by a profound dedication to the Brazilian Indian cause and to instilling in Brazilians a respect for Indian peoples. He influenced the Brazilian government in shaping a policy of protecting, assisting, and helping Indian peoples retain cohesive, self-determined societies. He also encouraged Indians to

  10. Robust estimation of Cronbach's alpha

    OpenAIRE

    2002-01-01

    Cronbach’s alpha is a popular method to measure reliability, e.g. in quantifying the reliability of a score to summarize the information of several items in questionnaires. The alpha coefficient is known to be non-robust. We study the behavior of this coefficient in different settings to identify situations, which can easily occur in practice, but under which the Cronbach’s alpha coefficient is extremely sensitive to violations of the classical model assumptions. Furthermore, we construct a r...

  11. Porøse materialer

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place

    2000-01-01

    Dette undervisningsnotat er en samling af noter, der refererer til den indledende del af kurset Materialmekanik og Porøse materailer på Insitut for Bærende Konstruktiner og Materialer (BKM).......Dette undervisningsnotat er en samling af noter, der refererer til den indledende del af kurset Materialmekanik og Porøse materailer på Insitut for Bærende Konstruktiner og Materialer (BKM)....

  12. PDFs, $\\alpha_s$, and quark masses from global fits

    CERN Document Server

    Alekhin, S; Moch, S; Placakyte, R

    2016-01-01

    The strong coupling constant $\\alpha_s$ and the heavy-quark masses, $m_c$, $m_b$, $m_t$ are extracted simultaneosly with the parton distribution functions (PDFs) in the updated ABM12 fit including recent data from CERN-SPS, HERA, Tevatron, and the LHC. The values of \\begin{eqnarray} \

  13. Aborto inducido: ética y derechos

    Directory of Open Access Journals (Sweden)

    Montserrat Sagot Rodríguez

    2002-09-01

    Full Text Available Si bien la interrupción voluntaria del embarazo es una práctica común en todo el mundo, el tema es sumamente controversias ya que en él se conjugan aspectos fundamentales como el inicio de la vida humana, el derecho de las mujeres a controlar su propio cuerpo, la sexualidad, la naturaleza de las responsabilidades del Estado para interferir en este terreno y las tensiones entre las visiones seculares y religiosas sobre la vida. El debate permite precisamente visibilizar el hecho de que sobre estos temas no existen visiones homogéneas e inmutables. En ese sentido, a pesar de que en muchos países existen leyes que penalizan el aborto, el asunto nos remite al terreno de principios morales y éticos contrapuestos. Aquí se discuten algunas de las implicaciones de estas controversias y se brinda información sobre la incidencia del aborto, así como sobre las consecuencias tanto del aborto inseguro como de la despenalización. Finalmente, se analizan las implicaciones de la penalización del aborto para el cumplimiento de algunos derechos fundamentales como el respeto a las diferencias, la libre elección, la autodeterminación y la tolerancia.Although abortion is commonly practiced throughout the world, it is a subject that arouses controversy because it raises fundamental questions about human existence, such as when life begins, the right of women to control their own bodies, sexuality, the nature of the State's duties in this matter, and the tension between secular and religious views of human life. This debate allows to make visible the fact that there are no homogencous or unchanging views on these subjects. In that sense, although in many countries the practice of abortion is iIlegal, the issue remits us more to the level of moral and ethical principles. In this article we discuss some of the implications of these controversies and provide information about the incidence of abortion, as well as of the consequences of both unsafe abortion and legalization of the practice. Finally, we analyze the implications of the laws that criminalize abortion on behalf of the fulfillment of some fundamental rights, such as the respect to differences, freedom of choice, self-determination and tolerance.

  14. Aborto inducido: ética y derechos

    OpenAIRE

    Montserrat Sagot Rodríguez; Ana Carcedo Cabañas

    2002-01-01

    Si bien la interrupción voluntaria del embarazo es una práctica común en todo el mundo, el tema es sumamente controversias ya que en él se conjugan aspectos fundamentales como el inicio de la vida humana, el derecho de las mujeres a controlar su propio cuerpo, la sexualidad, la naturaleza de las responsabilidades del Estado para interferir en este terreno y las tensiones entre las visiones seculares y religiosas sobre la vida. El debate permite precisamente visibilizar el hecho de que sobre e...

  15. Alpha glucosidase inhibitors.

    Science.gov (United States)

    Kalra, Sanjay

    2014-04-01

    Alpha glucosidase inhibitors (AGIs) are a unique class of anti-diabetic drugs. Derived from bacteria, these oral drugs are enzyme inhibitors which do not have a pancreato -centred mechanism of action. Working to delay carbohydrate absorption in the gastrointestinal tract, they control postprandial hyperglycaemia and provide unquestioned cardiovascular benefit. Specially suited for a traditional Pakistani carbohydrate-rich diet, AGIs have been termed the 'untapped diamonds' of diabetology. The use of these oral antidiabetic drugs (OADs) that target pathophysiology in the early stages of type 2 diabetes, notably to reduce postprandial hyperglycaemia and hyperinsulinaemia will inevitably increase with time. This review describes the history of their development, mechanism of action, basic and clinical pharmacology, and suggests practical, evidence-based guidance for their optimal use. PMID:24864650

  16. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  17. The Lyman alpha reference sample

    DEFF Research Database (Denmark)

    Hayes, M.; Östlin, G.; Schaerer, D.;

    2013-01-01

    We report on new imaging observations of the Lyman alpha emission line (Lyα), performed with the Hubble Space Telescope, that comprise the backbone of the Lyman alpha Reference Sample. We present images of 14 starburst galaxies at redshifts 0.028

  18. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  19. Alpha Schottky junction energy source

    Science.gov (United States)

    Litz, Marc S.; Fan, Zhaoyang; Carroll, James J.; Bayne, Stephen

    2012-06-01

    Isotope batteries offer solutions for long-lived low-power sensor requirements. Alpha emitting isotopes have energy per decay 103 times that of beta emitters. Alpha particles are absorbed within 20 μm of most materials reducing shielding mitigation. However, damage to materials from the alphas limits their practical use. A Schottky Barrier Diode (SBD) geometry is considered with an alpha emitting contact-layer on a diamond-like crystal semiconductor region. The radiation tolerance of diamond, the safety of alpha particles, combined with the internal field of the SBD is expected to generate current useful for low-power electronic devices over decades. Device design parameters and calculations of the expected current are described.

  20. Estudio del daño por hidrógeno en uniones soldadas de un acero API 5L X52

    Directory of Open Access Journals (Sweden)

    Réquiz, R.

    2008-04-01

    Full Text Available The main objective of the present investigation was to study the susceptibility to hydrogen damage on a type API 5L X52 steel welded by electrical resistance. Several techniques, such as hydrogen permeation and cathodic charging were used. The metallic material was characterized using SEM and TEM. The base metal microstructure was very similar to that one corresponding to the welded area. This microstructure was mainly comprised by ferrite and perlite, differing only in the grain size. Therefore, the susceptibility to hydrogen damage was similar in both cases. It is worth mentioning that the welded area has very small dimensions. Indeed, the fusion zone is only 5 mm wide while the heat affected zone is 1 mm wide. The hydrogen damage observed was mainly in the form of blisters, which were associated to the presence of aluminum rich inclusions. Also, it was noticed partial inclusion dissolution and some matrix attack adjacent to the inclusions.

    En la presente investigación se estudió la susceptibilidad al daño por hidrógeno en un acero API 5L X52 soldado por resistencia eléctrica. Para ello, se emplearon técnicas de permeación y de carga catódica de hidrógeno. El material fue caracterizado mediante microscopía electrónica de barrido y de transmisión. La susceptibilidad al daño por hidrógeno fue similar tanto en el metal base como en el cordón de soldadura. Este comportamiento se vincula a la microestructura homogénea constituida por perlita y ferrita, que presentan ambos, aun cuando existen diferencias en el tamaño de grano. El cordón de soldadura tenía dimensiones muy pequeñas, donde la zona de fusión y la afectada por el calor poseen espesores de 5 mm y 1 mm, respectivamente. El daño inducido por hidrógeno se presentó en forma de ampollas en la superficie del material, asociado, principalmente, a la presencia de inclusiones globulares y semiglobulares ricas en aluminio. Además, se manifestó una disoluci

  1. Se los por se lo

    OpenAIRE

    José Luis Rivarola

    1985-01-01

    El sistema de la conjugación "objetiva" plantea interesantesproblemas que fueron tratados en parte por K. Heger (1966) en suestudio comparativo del francés y del español. De la comparaciónse desprende, por ejemplo, que en español hay un cierto número deambigüedades que no permiten establecer un "paradigma tan completo y unívoco" como en el caso del francés. Dentro de estas ambigüedades se encuentran las que propicia el gramema se: "El morfema [gramema] se funciona no sólo como pronombre refle...

  2. Ptose palpebral causada por Paquidermoperiostose

    Directory of Open Access Journals (Sweden)

    Patricia Regina de Pinho Tavares

    2014-08-01

    Full Text Available A paquidermoperiostose é uma síndrome caracterizada por acometimento cutâneo e ósseo, e em alguns casos ocorre comprometimento palpebral leve. É uma síndrome rara, idiopática ou hereditária, com provável herança autossômica dominante de penetrância variável. Descreve-se o caso de um paciente com ptose grave por paquidermoperiostose elucidando sua fisiopatologia e conduta cirúrgica aplicada.

  3. Laser-assisted {alpha} decay

    Energy Technology Data Exchange (ETDEWEB)

    Castaneda Cortes, Hector Mauricio; Palffy, Adriana; Keitel, Christoph H. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Popruzhenko, Sergey [Moscow State Engineering Physics Institute (Russian Federation)

    2012-07-01

    The spontaneous emission of alpha particles by unstable nuclei was one of the first physical processes to be described by quantum tunneling of a quasistationary state, i.e. a long-lived state. The development of new powerful coherent light sources opens the possibility to study the direct interaction between strong laser fields and atomic nuclei, assisting the tunneling of the {alpha} particle through the nuclear barrier. In this work we investigate for the first time the effect of strong laser fields on the tunneling and {alpha} particle emission of several medium-mass and heavy nuclei. To this end we make use of the formalism we have developed starting from the well-known Strong-Field Approximation and its complex trajectories formulation to describe the laser-assisted decay of quasistationary states [1]. The effect of a static as well as optical and X-ray monochromatic fields on the {alpha} decay lifetimes and {alpha} particle emission spectra is determined. We find that even at strong intensities, the laser-induced acceleration of the {alpha} decay is negligible, and only the spectra are significantly changed by the laser field. In particular, for optical fields, high laser intensities can lead to rescattering of the {alpha} particle off the daughter nucleus.

  4. ALPHA freezes antiprotons

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Laboratories like CERN can routinely produce many different types of antiparticles. In 1995, the PS210 experiment formed the first antihydrogen atoms and a few years later, in 2002, ATRAP and ATHENA were already able to produce several thousand of them. However, no experiment in the world has succeeded in ‘trapping’ these anti-atoms in order to study them. This is the goal of the ALPHA experiment, which has recently managed to cool down the antiprotons to just a few Kelvin. This represents a major step towards trapping the anti-atom, thus opening a new avenue into the investigation of antimatter properties.   Members of the ALPHA collaboration working on the apparatus in the Antiproton Decelerator experimental hall at CERN. Just like the atom, the anti-atom is neutral. Unlike the atom, the anti-atom is made up of antiprotons (as opposed to protons in the atom) and positrons (as opposed to electrons). In order to thoroughly study the properties of the anti-atoms, scien...

  5. Capacidad antiteratogénica del resveratrol en diabetes inducida por estreptozotocina en ratas

    Directory of Open Access Journals (Sweden)

    Ninna Leslie Trejo-González

    2015-07-01

    Full Text Available Objetivos. Evaluar la capacidad antihiperglucémica y antiteratogénica del resveratrol en ratas inducidas a diabetes por estreptozotocina. Materiales y métodos. Estudio de tipo experimental. Se tuvieron tres grupos, de cinco ratas Wistar preñadas cada uno, dos de los cuales fueron tratados el cuarto día de gestación con una dosis de estreptozotocina de 50 mg/kg, disuelta en tampón de citratos, y el otro fue considerado como control, y solo se le administró el tampón de citratos. A uno de los grupos inducidos con estreptozotocina se le administró resveratrol a dosis de 100 mg/kg durante los días 8 al 12 de gestación, cuando sucede la neurulación. Los fetos se obtuvieron el día 19 de gestación y se les realizó un análisis morfológico, y en el hígado fetal se determinó la actividad de las enzimas depuradoras de especies reactivas catalasa, superóxido dismutasa y glutatión peroxidasa. Resultados. La administración de resveratrol (DM+R revierte los parámetros a valores similares a los del grupo control. Las actividades de catalasa y de glutatión peroxidasa, se vieron incrementadas en el grupo tratado con resveratrol con respecto al grupo diabético, en cuanto a la frecuencia de malformaciones en el grupo control y en el grupo tratado con resveratrol no presentaron malformaciones, mientras que en las ratas con diabetes inducida, se encontró una elevada frecuencia de malformaciones. Conclusiones. El resveratrol muestra propiedades antiteratogénicas a través de la disminución del estrés oxidativo que se presenta a causa de la hiperglucemia materna

  6. Capacidad antiteratogénica del resveratrol en diabetes inducida por estreptozotocina en ratas

    Directory of Open Access Journals (Sweden)

    Ninna Leslie Trejo-González

    2015-09-01

    Full Text Available Objetivos. Evaluar la capacidad antihiperglucémica y antiteratogénica del resveratrol en ratas inducidas a diabetes por estreptozotocina. Materiales y métodos. Estudio de tipo experimental. Se tuvieron tres grupos, de cinco ratas Wistar preñadas cada uno, dos de los cuales fueron tratados el cuarto día de gestación con una dosis de estreptozotocina de 50 mg/kg, disuelta en tampón de citratos, y el otro fue considerado como control, y solo se le administró el tampón de citratos. A uno de los grupos inducidos con estreptozotocina se le administró resveratrol a dosis de 100 mg/kg durante los días 8 al 12 de gestación, cuando sucede la neurulación. Los fetos se obtuvieron el día 19 de gestación y se les realizó un análisis morfológico, y en el hígado fetal se determinó la actividad de las enzimas depuradoras de especies reactivas catalasa, superóxido dismutasa y glutatión peroxidasa. Resultados. La administración de resveratrol (DM+R revierte los parámetros a valores similares a los del grupo control. Las actividades de catalasa y de glutatión peroxidasa, se vieron incrementadas en el grupo tratado con resveratrol con respecto al grupo diabético, en cuanto a la frecuencia de malformaciones en el grupo control y en el grupo tratado con resveratrol no presentaron malformaciones, mientras que en las ratas con diabetes inducida, se encontró una elevada frecuencia de malformaciones. Conclusiones. El resveratrol muestra propiedades antiteratogénicas a través de la disminución del estrés oxidativo que se presenta a causa de la hiperglucemia materna

  7. Partitioning $\\alpha$-large sets for $\\alpha<\\varepsilon_{\\omega}$

    CERN Document Server

    De Smet, Michiel

    2010-01-01

    We generalise the results by Bigorajska and Kotlarski about partitioning $\\alpha$-large sets, by extending the domain up to ordinals below $\\varepsilon_{\\omega}$. These results will be very useful to give a miniaturisation of the infinite Ramsey Theorem.

  8. Synthesis of a precursor for the preparation of 9 alpha,11 alpha-tritiated 5 alpha-androstane-3 alpha,17 beta-diol 17-glucuronide

    International Nuclear Information System (INIS)

    Starting from 11 beta-hydroxytestosterone, the synthesis of a strategic precursor, C-9 (11) unsaturated 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide (9a), for the preparation of 9 alpha,11 alpha-tritiated 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide has been achieved. The authors optimized the reaction conditions for catalytic reduction employing hydrogen and subsequent base hydrolysis followed by purification on Amberlite XAD-2 resin to obtain the saturated 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide

  9. Celulitis por citomegalovirus Cytomegalovirus cellulitis

    Directory of Open Access Journals (Sweden)

    A. Ruiz Lascano

    2002-12-01

    Full Text Available Las lesiones cutáneas por citomegalovirus (CMV son infrecuentes y a menudo una manifestación tardía de una enfermedad sistémica, que generalmente anuncia un curso fatal. Comunicamos un caso de celulitis por CMV: una mujer de 70 años con trasplante renal efectuado 1 mes antes de la consulta, terapia inmunosupresora con ciclosporina A y metilprednisona. La paciente ingresó por fiebre, dolor e impotencia funcional en pierna derecha. Comprobamos la existencia de una placa de 8 por 4 cm eritematoedematosa. La tratamos con antibióticos sin mejoría, por lo que realizamos un estudio histopatológico de piel que mostró cambios citopáticos compatibles con infección por CMV. Los cultivos bacteriológicos y micológicos fueron negativos. La inmunohistoquímica específica para CMV y el estudio de reacción en cadena de la polimerasa (PCR de la biopsia de piel fueron positivas, al igual que la antigenemia. El tratamiento con ganciclovir produjo la mejoría del cuadro clínico. En la literatura revisada no hemos encontrado la celulitis como manifestación de enfermedad cutánea por CMV.Cutaneous lesions in CMV infection are rare, often a late manifestation of systemic infection, and usually herald a fatal course. A 70 year-old woman received a kidney transplantation one month before consulting and immunosuppressive therapy that included cyclosporine A and methylprednisone. She complained of fever, local pain in her right leg, and an erythematous and swelling plaque. She was treated with intravenous antibiotics without improvement. A skin biopsy was performed and the tissue obtained was sent for bacterial and fungal cultures as well as for histological examination. Cultures were negative. The biopsy showed CMV cytopathic changes. Immunoperoxidase staining was positive for CMV and polymerase chain reaction (PCR testing revealed CMV DNA. She was treated with ganciclovir with resolution of the lesion. CMV cellulitis is a rare cutaneous manifestation

  10. Alpha thalassaemia in British people.

    OpenAIRE

    Higgs, D R; Ayyub, H.; Clegg, J B; Hill, A V; Nicholls, R D; Teal, H; Wainscoat, J.S. (James S.); Weatherall, D. J.

    1985-01-01

    Although alpha thalassaemia is rare in north Europeans, it has been identified in British people with no known foreign ancestry. Twelve such patients were studied, of whom eight shared a distinctive molecular defect, which was clearly different from defects seen in subjects of Mediterranean or South East Asian origin. A rare but specific form of alpha thalassaemia is therefore present in the British population. In addition, two patients from families of mixed racial origin were encountered wh...

  11. Almost Redundant Components in the 3 alpha Faddeev Equation for the Buck, Friedlich and Wheatly alpha alpha Potential

    CERN Document Server

    Fujiwara, Y; Kohno, M

    2004-01-01

    The 3 alpha orthogonality condition model using the Pauli-forbidden bound states of the Buck, Friedlich and Wheatly alpha alpha potential can yield a compact 3 alpha ground state with a large binding energy, in which a small admixture of the redundant components can never be eliminated.

  12. (phoenicopterus roseus por intoxicación aguda por plomo

    Directory of Open Access Journals (Sweden)

    D Romero

    2007-01-01

    Full Text Available La presencia de plomo en el medio ambiente es un hecho indiscutible. Ello es objeto de gran interés sanitario pues repercute tanto en la salud de los animales como en la del ser humano. El plumbismo es una intoxicación que puede afectar a cualquier especie animal. En el ámbito de la fauna silvestre se asocia principalmente a la actividad cinegética en los humedales y a la ingestión de plomo metálico por parte de las aves que frecuentan estos ecosistemas. En España cada año mueren decenas de miles de aves acuáticas como consecuencia de la ingesta de perdigones de plomo. En los individuos capturados enfermos se pueden observar signos clínicos, mientras que a partir de muestras de cadáveres se obtienen datos sobre niveles tisulares de plomo. Sin embargo la evaluación de lesiones anatomopatológicas en animales de vida silvestre es difícil de realizar por la dificultad de encontrar animales recién muertos o afectados de un cuadro agudo mortal. La reproducción de esta patología en animales de experimentación se suele realizar en cisnes, palomas o patos, pero no en flamencos, por lo que no es usual disponer de datos histológicos en esta especie. En este trabajo presentamos la clínica, analítica y estudio microscópico de diferentes tejidos de un flamenco común (Phoenicopterus roseus muerto por plumbismo.

  13. Se los por se lo

    Directory of Open Access Journals (Sweden)

    José Luis Rivarola

    1985-12-01

    Full Text Available El sistema de la conjugación "objetiva" plantea interesantesproblemas que fueron tratados en parte por K. Heger (1966 en suestudio comparativo del francés y del español. De la comparaciónse desprende, por ejemplo, que en español hay un cierto número deambigüedades que no permiten establecer un "paradigma tan completo y unívoco" como en el caso del francés. Dentro de estas ambigüedades se encuentran las que propicia el gramema se: "El morfema [gramema] se funciona no sólo como pronombre reflexivo, sinotambién como variante combinatoria del pronombre personal complemento indirecto de la tercera persona.

  14. por el Tribunal Constitucional chileno

    Directory of Open Access Journals (Sweden)

    Marisol Peña Torres

    2008-01-01

    Full Text Available La modificación introducida por la reforma constitucional de agosto de 1989 al artículo 5º de la Constitución chilena sentó un criterio decisivo en la incorporación del derecho internacional de los derechos humanos al ordenamiento jurídico interno. El artículo examina la jurisprudencia del Tribunal Constitucional antes y después de esa reforma distinguiendo entre la aplicación del Derecho Internacional de los Derechos Humanos por haberse invocado en la acción deducida y la aplicación de principios y criterios hermenéuticos extraídos del mismo.

  15. DETERMINACIÓN DE LOS NIVELES DE FUERZA MÁXIMA APLICADA, VELOCIDAD Y POTENCIA POR MEDIO DE UN TEST CRECIENTE EN PRES DE BANCA PLANO, EN LEVANTADORES ESPAÑOLES.

    Directory of Open Access Journals (Sweden)

    Joaquín Figueroa Alchapar

    2010-10-01

    Full Text Available

     

    Se evaluaron 9 levantadores que realizaron 2 test en el ejercicio de pres debanca: a Progresivo con pesos ligeros a máximos (MRPr b Máxima Repetición (MRD. Semidió la fuerza (FN, velocidad (V y potencia (W con cada peso movilizado,determinándose el máximo peso factible de movilizar 1 vez y no dos (MR Se observaroncorrelaciones significativas entre la MR del test MRPr y la del MRD, la W máxima, absolutay relativa al peso corporal y la MR absoluta y relativa al peso corporal, no se produjerondiferencias significativas (p<0,05 entre la MR obtenidas en el test MRPr y MRD. Se aceptala aplicación del test MRPr para determinar los niveles de FN, V, W, y MR, localizar losniveles de W máxima, con relación al % MR, y determinar el perfil de rendimiento así comolos cambios inducidos por los entrenamientos de fuerza.

    Palabras Clave: Fuerza Máxima, Velocidad, potencia

  16. Sepsis neonatal por Estreptococos Pyogenes

    Directory of Open Access Journals (Sweden)

    Gilberto Rodríguez-Herrera

    2009-09-01

    Full Text Available Se presenta el caso de un paciente masculino, recién nacido a término adecuado para la edad gestacional, quien nace por parto vaginal, con el antecedente de fiebre en la madre durante el periodo de postparto inmediato. Los padres consultan a los 2 días de vida pues le notan dificultad respiratoria, hipoactividad y rechazo a la leche materna. El paciente se interna y se aborda como una sepsis. Durante su estancia en el servicio de neonatología del Hospital Nacional de Niños asocia fallo respiratorio que amerita ventilación mecánica asistida por varios días en diferentes ocasiones, derrame pleural exudativo, convulsiones de origen hipóxico isquémico. Con reporte de hemocultivos positivos por Estreptococos pyogenes. El Estreptococos pyogenes o estreptococo β-hemolνtico del grupo A, fue un problema en los comienzos del siglo pasado, siendo frecuente en las infecciones puerperales y del reciιn nacido. En la actualidad es un germen sumamente raro en los procesos de sepsis neonatal.2 La gravedad de la enfermedad causada por este microorganismo en el periodo neonatal varνa desde una onfalitis crónica de bajo grado a una septicemia, una meningitis fulminante y la muerte.1 El presente artículo pretende hacer un resumen del paciente, con su evolución clínica, radiológica y además ejemplificar todas las complicaciones que tuvimos con este germen tan poco frecuente en la actualidad en sepsis neonatal.

  17. Gaseous alpha emitter diffusion studies using alpha track method

    International Nuclear Information System (INIS)

    Using a very accurate and sensitive analysis method such as alpha track method, the SSNTD group was able to undertake studies on the atomic and molecular processes taking place at low speed and/or very low concentrations, such as diffusion of gaseous alpha radionuclides in gaseous media. For practical application reasons, we began to study the diffusion in air for gaseous alpha radionuclides and aerosols carrying solid alpha radionuclides. The used alpha radionuclides were: Rn-222, as gaseous radionuclide and its solid descendants genetically related, attached to different particles from air, as radioactive aerosols. The source was included into an air tight device with a very well known volume. After 40 days, the radioactive equilibrium was established for all descendants, so that in the device there were the Rn-222 and its descendants, each of them having the same activity. The relative amount/activity ratio of each decay product, at any duration, for any initial mass of Ra-226 parent radionuclide, were calculated using the code UURASE, based on the Bateman general equations, for computing the U-238 radioactive series gamma accumulation. This was adapted for alpha accumulation as ALFAURASE programme. The device which contains the Ra-226 source can be coupled to the calibration system or to the diffusion system, without destroying the radioactive equilibrium. At this coupling, only the radioactive concentration is changed due to the variation of the volume. First of all the device was used for calibrating the CR-39 track detectors for both Rn-222 gaseous radionuclide and aerosol concentration measurements using, in the coupled calibration system, a special 'detector-container' equipped/or not with a filter used for radioactive aerosol stopping. The track detectors CR-39 were etched in NaOH 30%, for 7 hours at 70 deg. C and their studies were performed by optical microscopy using a stereo-microscope Wild M7S and a binocular Zeiss Jena microscope. (authors)

  18. Evaluation of the antitumor activity of interleukin-12 in an experimental murine model of colorectal cancer induced by 1,2 dimethylhydrazine (DMH Estudio de la respuesta antitumoral de la interleucina-12 en cáncer de colon inducido mediante 1,2-dimetilhidracina (DMH

    Directory of Open Access Journals (Sweden)

    S. Coca

    2005-09-01

    I (p=0.028 and group III (p = 0.019. Other parameters measured, such as biggest tumor size and total tumoral volume were found to be lower in group II, although no statistical differences were found between groups. Only 10% of rats in group I showed moderated/extensive NK cell infiltration, vs. 60% of rats in group II (p = 0.077 and 70% in group III (p = 0.02. Conclusion: The administration of DMH to rodents provides a reliable and consistent means of inducing CRC that may be suitable for the evaluation of anti-cancer therapies. Our findings suggest that IL-12 is effective against the development of experimental CRC. Its antineoplastic effect could be attributed to the stimulus of this cytokine on the intratumoral infiltration of NK cells.Objetivo: la interleucina (IL-12 es una citocina que estimula la proliferación y la actividad citotóxica de los linfocito T y las células natural killer (NK. En trabajos previos se ha observado una relación entre la infiltración intratumoral de células NK y una mayor supervivencia en carcinomas colorrectales (CCR. Existen evidencias de un efecto aditivo en la actividad inmunomoduladora de la asociación de IL-12 con IL-2. Así, nos hemos propuesto el estudio de la capacidad de respuesta inmune antitumoral, tras la administración sistémica de IL-12 sola o combinada con IL-2, en un modelo experimental de CCR inducidos mediante la administración de 1,2-dimetilhidracina (DMH. Método: sesenta y cinco ratas Wistar de 6 semanas a las que se administró en inyección subcutánea una dosis semanal de DMH a razón de 20 mg/kg de peso durante 26 semanas. Finalizado el periodo de inducción, los animales se distribuyeron aleatoriamente en tres grupos. I: grupo control. Grupo II, se administró IL-12 recombinante murina. Grupo III: se administró IL-12, combinada con IL-2. Las ratas se sacrificaron en la semana 30, estudiándose los siguientes parámetros: número y localización de tumores, tamaño y carga tumoral. Se realiz

  19. Workshop on Precision Measurements of $\\alpha_s$

    Energy Technology Data Exchange (ETDEWEB)

    Bethke, Siegfried; /Munich, Max Planck Inst.; Hoang, Andre H.; /Vienna U.; Kluth, Stefan; /Munich, Max Planck Inst.; Schieck, Jochen; /Munich U.; Stewart, Iain W.; Aoki, S.; Beneke, M.; Bethke, S.; Blumlein, J.; Brambilla, N.; Brodsky, S.; /MIT, LNS

    2011-10-01

    These are the proceedings of the Workshop on Precision Measurements of {alpha}{sub s} held at the Max-Planck-Institute for Physics, Munich, February 9-11, 2011. The workshop explored in depth the determination of {alpha}{sub s}(m{sub Z}) in the {ovr MS} scheme from the key categories where high precision measurements are currently being made, including DIS and global PDF fits, {tau}-decays, electro-weak precision observables and Z-decays, event-shapes, and lattice QCD. These proceedings contain a short summary contribution from the speakers, as well as the lists of authors, conveners, participants, and talks.

  20. Desajuste educativo por regiones en Colombia: ¿competencia por salarios o por puestos de trabajo?

    Directory of Open Access Journals (Sweden)

    Castillo Caicedo Maribel

    2007-08-01

    Full Text Available Este trabajo aporta una perspectiva del fenómeno de la sobreeducación,
    entendida como un desajuste por exceso, entre el nivel educativo alcanzado
    por el individuo y el exigido por el puesto de trabajo en el cual se
    desempeña; esto se debe a que existe una demanda laboral estrecha de
    puestos de trabajo para personas calificadas en Colombia. Se analizan las
    contribuciones empíricas existentes y el debate sobre las mismas; se
    examinan las teorías que permiten explicar la existencia de un desajuste
    educativo y se realiza una revisión de la literatura internacional y
    nacional sobre el tema. Adicionalmente, se plantean una serie de hipótesis
    para desarrollar un esquema que permita determinar el comportamiento
    del individuo en el fenómeno de la sobreeducación.

  1. Efecto del OLEOZON® frente a lesiones gástricas inducidas por indometacina en ratas (Effect of OLEOZON® on gastric lesions induced by indomethacin in rats

    Directory of Open Access Journals (Sweden)

    González Alvarez Ricardo

    2007-03-01

    Full Text Available El aceite de girasol ozonizado es un fármaco registrado en Cuba para el tratamiento de la giardiasis con el nombre de OLEOZON®; los ensayos clínicos realizados han demostrado que posee efectividad terapéutica comparable con un fármaco de referencia, Ornidazol. Elobjetivo del presente estudio fue determinar si el Oleozon es capaz de ejercer efecto protector contra las lesiones gástricas inducidas por la indometacina en las ratas. Estos animales fueron divididos para dos diferentes diseños experimentales con 6 grupos cada uno. En el primer experimento las ratas fueron pretratadas oralmente conOleozon (4, 12 y 24 mg/kg y 4 horas después con indometacina. En el segundo experimento las lesiones gástricas fueron inducidas por indometacina y 4 horas después tratadas con Oleozon en el mismo rango de dosis que en el anterior experimento. Las lesiones gástricas fueron evaluadas determinando el índice de ulceración. La Cimetidina fue utilizada como fármaco antiulceroso de referencia. Los resultadosdemostraron que el pretratamiento con Oleozon no impidió el daño gástrico inducido por la indometacina y no tuvo efecto citoprotector. En contraste con esto el tratamiento con Oleozon indujo reversión delas lesiones gástricas inducidas previamente por la indometacina demostrando su efecto anti-ulcerogénico en este modelo. Ozonized sunflower oil is a drug registered in Cuba for the treatment of giardiasis and it is commercially available with the name ofOleozon. The clinical trials have demonstrated that Oleozon possess therapeutic effectiveness comparable with a reference drug, Ornidazol. The aim of the present study was to determine whether Oleozon is able to exert protective effects against gastric lesionsinduced by indomethacin in rats. The animals were divided for two different experimental designs with six groups each one. In the firstexperiment the rats were pretreated with Oleozon (4, 12 y 24 mg/kg and four hours thereafter with

  2. La ozonoterapia protege los túbulos proximales de la corteza renal del daño por isquemia-reperfusión. Estudio morfométrico preliminar

    Directory of Open Access Journals (Sweden)

    Enoy Leiva Pantoja

    2010-01-01

    Full Text Available La isquemia-reperfusión renal es causa de insuficiencia renal aguda, la cual presenta un elevado índice de mortalidad. Actualmente, los tratamientos empleados en la recuperación del riñón sometido a isquemia-reperfusión tienen un éxito limitado. Por tanto, se hace necesaria la búsqueda de estrategias terapéuticas efectivas que ayuden a prevenir el daño renal. La característica histopatológica más prominente de la isquemia-reperfusión renal es la lesión de los túbulos proximales corticales. El objetivo de este trabajo fue evaluar el efecto del precondicionamiento oxidativo con ozono sobre la morfología de los túbulos proximales de la corteza renal, ante el daño por isquemia-reperfusión. Se estudiaron fragmentos de corteza renal procedentes de 16 ratas, divididas en cuatro grupos: controles, dañadas por isquemia-reperfusión (60 min de isquemia seguidos por 180 min de reperfusión y dos grupos de ratas precondicionadas con ozono (0,5 y 1,1 mg/kg de peso corporal respectivamente y sometidas a isquemia-reperfusión. Las muestras se procesaron según la técnica convencional de inclusión en resina Spurr. Se realizaron cortes semifinos, que se analizaron cualitativa y cuantitativamente por Microscopia Óptica. Se identificaron los marcadores morfológicos del daño renal inducido por isquemia-reperfusión sobre los túbulos proximales renales: pérdida del ribete en cepillo, dilatación tubular, aumento de áreas y perímetros tubulares, necrosis celular y aumento de núcleos de células epiteliales en la luz tubular, relacionado con la formación de cilindros. El precondicionamiento oxidativo con ozono condujo a la recuperación de la morfología de los túbulos proximales. Al propiciar la protección de las células epiteliales de los túbulos proximales renales, la ozonoterapia podría considerarse una herramienta efectiva ante el daño por isquemia-reperfusión renal.

  3. Conditioning of alpha bearing wastes

    International Nuclear Information System (INIS)

    Alpha bearing wastes are generated during the reprocessing of spent fuel, mixed oxide fuel fabrication, decommissioning and other activities. The safe and effective management of these wastes is of particular importance owing to the radiotoxicity and long lived characteristics of certain transuranic (TRU) elements. The management of alpha bearing wastes involves a number of stages which include collection, characterization, segregation, treatment, conditioning, transport, storage and disposal. This report describes the currently available matrices and technologies for the conditioning of alpha wastes and relates them to their compatibility with the other stages of the waste management process. The selection of a specific immobilization process is dependent on the waste treatment state and the subsequent handling, transport, storage and disposal requirements. The overall objectives of immobilization are similar for all waste producers and processors, which are to produce: (a) Waste forms with sufficient mechanical, physical and chemical stability to satisfy all stages of handling, transport and storage (referred to as the short term requirements), and (b) Waste forms which will satisfy disposal requirements and inhibit the release of radionuclides to the biosphere (referred to as the long term requirements). Cement and bitumen processes have already been successfully applied to alpha waste conditioning on the industrial scale in many of the IAEA Member States. Cement systems based on BFS and pozzolanic cements have emerged as the principal encapsulation matrices for the full range of alpha bearing wastes. Alternative technologies, such as polymers and ceramics, are being developed for specific waste streams but are unlikely to meet widespread application owing to cost and process complexity. The merits of alpha waste conditioning are improved performance in transport, storage and disposal combined with enhanced public perception of waste management operations. These

  4. Test chamber for alpha spectrometry

    Science.gov (United States)

    Larsen, Robert P.

    1977-01-01

    Alpha emitters for low-level radiochemical analysis by measurement of alpha spectra are positioned precisely with respect to the location of a surface-barrier detector by means of a chamber having a removable threaded planchet holder. A pedestal on the planchet holder holds a specimen in fixed engagement close to the detector. Insertion of the planchet holder establishes an O-ring seal that permits the chamber to be pumped to a desired vacuum. The detector is protected against accidental contact and resulting damage.

  5. Clonagem de canistel por estaquia

    Directory of Open Access Journals (Sweden)

    Fernando Marcelo Chiamolera

    2014-09-01

    Full Text Available O canistel é nativo do sul do México e América Central e seus frutos apresentam elevado teor de carotenoides e vitamina A. Sua propagação é feita via sementes, resultando em considerável variabilidade genética entre os indivíduos, sendo a propagação vegetativa preferível, a fim de fixar características desejáveis. Assim, o objetivo deste trabalho foi avaliar a propagação vegetativa por estaquia de ramos semi-herbáceos de canistel, em função de quatro genótipos e quatro concentrações de AIB. Foram utilizadas estacas semiherbáceas apicais, mantidas com um par de folhas, sob nebulização intermitente, por 120 dias. O delineamento experimental foi o inteiramente casualizado, em esquema fatorial 4×4 (genótipos de canistel × concentrações de AIB, com quatro repetições e dez estacas por parcela. Foram avaliados a porcentagem de sobrevivência, a retenção foliar, o enraizamento, o calejamento, o número e o comprimento médio de raízes por estaca. O genótipo PC-1 foi superior aos demais, em todas as variáveis avaliadas, com destaque para o enraizamento das estacas, superior a 60%. As concentrações de AIB (0; 1.000; 3.000 e 5.000 mg L-1 não influenciaram na sobrevivência, retenção foliar e enraizamento das estacas, mas aumentaram o número e o comprimento de raízes em relação ao tratamento-controle (sem AIB. Há diferença na capacidade de enraizamento das estacas entre os genótipos de canistel, sendo a melhor resposta obtida com PC-1. A concentração de 3.000 mg L-1 de AIB resulta em maior número e comprimento de raízes nas estacas de canistel.

  6. Once mil metros por segundo

    OpenAIRE

    2012-01-01

    Esta exposición es una ventana hacia el mundo de la Ciencia Ficción. Los sueños de escritores extraordinarios, personajes, lugares, máquinas y robots que cada día están más cerca de nuestra cotidianidad gracias a los avances de la ciencia y la tecnología hacen parte de la muestra itinerante por las sedes de la Universidad Nacional. El visitante puede recorrer los diferentes géneros que constituyen este género literario, además de conocer sus principales representantes. Así mismo se explor...

  7. Sepsis neonatal por Estreptococos Pyogenes

    OpenAIRE

    Gilberto Rodríguez-Herrera; Cinthya Ramírez-Navarro

    2009-01-01

    Se presenta el caso de un paciente masculino, recién nacido a término adecuado para la edad gestacional, quien nace por parto vaginal, con el antecedente de fiebre en la madre durante el periodo de postparto inmediato. Los padres consultan a los 2 días de vida pues le notan dificultad respiratoria, hipoactividad y rechazo a la leche materna. El paciente se interna y se aborda como una sepsis. Durante su estancia en el servicio de neonatología del Hospital Nacional de Niños asocia fallo respir...

  8. Miasis ocular por Oestrus ovis

    Directory of Open Access Journals (Sweden)

    María Beltrán F

    2006-01-01

    Full Text Available Se presentan tres casos de miasis ocular (dos adultos y un niñoprocedentes de zonas ganaderas de la provincia de Huaura,departamento de Lima,que acudieron al Hospital Regional de Huacho por presentar el ojo rojo,fotofobia, edema palpebral y sensación de cuerpo extraño;se extrajeron larvas adheridas al canto interno del ojo,las cuales se recibieron en el Instituto Nacional de Salud y fueron identificadas como Oestrus ovis .

  9. Polioencefalomalacia experimental em bovinos induzida por toxicose por enxofre

    Directory of Open Access Journals (Sweden)

    Paulo H.J. Cunha

    2011-01-01

    Full Text Available O presente trabalho teve como objetivos avaliar os sinais clínicos, as concentrações do sulfeto de hidrogênio ruminal e as alterações anatomopatológicas associadas à intoxicação experimental por enxofre em bovinos. Foram utilizados dez bezerros mestiços leiteiros, sendo que quatro bovinos ingeriram ração sem sulfato de sódio (G1 e seis consumiram ração com sulfato de sódio (G2. Exames clínicos (temperatura retal, frequência cardíaca e respiratória e motricidade ruminal e laboratoriais (hemograma, fibrinogênio, proteína plasmática, pH do fluido ruminal, concentração do sulfeto de hidrogênio ruminal, líquido cerebrospinal e histopatológico foram realizados. A temperatura retal, frequência cardíaca, hemograma, fibrinogênio, proteína plasmática, pH do fluido ruminal e os valores do líquido cerebrospinal estavam dentro dos valores de referência para a espécie. Taquipnéia, hipomotricidade ruminal e elevados valores de sulfeto de hidrogênio ruminal foram observados nos bezerros do grupo G2. Um bezerro do grupo G2 apresentou sinais neurológicos e lesões histopatológicas de PEM. Dois animais de cada grupo foram eutanasiados. Lesões microscópicas foram observadas nos bezerros do G2. Histologicamente as alterações observadas foram necrose neuronal cortical e lesões hemorrágicas nos núcleos basais, tálamo, mesencéfalo, ponte e bulbo. O protocolo experimental constituído por uma dieta rica em carboidrato de alta fermentação, baixa quantidade de fibra efetiva e altos níveis de enxofre (0,52% ocasionou alterações clinicas e histológicas e elevadas concentrações de sulfeto de hidrogênio ruminal compatíveis com quadro de intoxicação por enxofre.

  10. Hipoglucemia inducida por carcinoma adrenal

    Directory of Open Access Journals (Sweden)

    Jimena Soutelo

    2013-08-01

    Full Text Available El carcinoma suprarrenal es una neoplasia maligna infrecuente y de mal pronóstico. La presentación clínica más común es originada por la producción hormonal excesiva, mientras que el desarrollo de hipoglucemia sintomática es excepcional. Presentamos el caso de una mujer de 37 años que ingresó al hospital por síntomas de hipoglucemias graves, hipertensión arterial, hipopotasemia y amenorrea secundaria. En el laboratorio se halló hipoglucemia con insulina inhibida y niveles de andrógenos en rango tumoral. La tomografía computarizada (TC de abdomen y pelvis mostró voluminosa formación heterogénea de aspecto sólido sin plano de clivaje con respecto al parénquima hepático e intenso realce con contraste. Luego de la extirpación de la masa retroperitoneal, evolucionó con valores de glucemia y potasemia normales, estabilizó la presión arterial y recuperó los ciclos menstruales.

  11. Inflaton Decay in an Alpha Vacuum

    CERN Document Server

    Naidu, S; Naidu, Siddartha; Holman, Richard

    2004-01-01

    We study the alpha vacua of de Sitter space by considering the decay rate of the inflaton field coupled to a scalar field placed in an alpha vacuum. We find an {\\em alpha dependent} Bose enhancement relative to the Bunch-Davies vacuum and, surprisingly, no non-renormalizable divergences. We also consider a modified alpha dependent time ordering prescription for the Feynman propagator and show that it leads to an alpha independent result. This result suggests that it may be possible to calculate in any alpha vacuum if we employ the appropriate causality preserving prescription.

  12. What Powers Lyman alpha Blobs?

    CERN Document Server

    Ao, Y; Beelen, A; Henkel, C; Cen, R; De Breuck, C; Francis, P; Kovacs, A; Lagache, G; Lehnert, M; Mao, M; Menten, K M; Norris, R; Omont, A; Tatemastu, K; Weiss, A; Zheng, Z

    2015-01-01

    Lyman alpha blobs (LABs) are spatially extended lyman alpha nebulae seen at high redshift. The origin of Lyman alpha emission in the LABs is still unclear and under debate. To study their heating mechanism(s), we present Australia Telescope Compact Array (ATCA) observations of the 20 cm radio emission and Herschel PACS and SPIRE measurements of the far-infrared (FIR) emission towards the four LABs in the protocluster J2143-4423 at z=2.38. Among the four LABs, B6 and B7 are detected in the radio with fluxes of 67+/-17 microJy and 77+/-16 microJy, respectively, and B5 is marginally detected at 3 sigma (51+/-16 microJy). For all detected sources, their radio positions are consistent with the central positions of the LABs. B6 and B7 are obviously also detected in the FIR. By fitting the data with different templates, we obtained redshifts of 2.20$^{+0.30}_{-0.35}$ for B6 and 2.20$^{+0.45}_{-0.30}$ for B7 which are consistent with the redshift of the lyman alpha emission within uncertainties, indicating that both ...

  13. Alpha Testing Escape from Diab

    Science.gov (United States)

    Alpha testing was conducted of sessions 2 and 3 from Diab to assess whether the activities worked as expected, and whether children in the target ages enjoyed it. Data include both RA observations of child performance while playing the games and cognitive interview responses from the players after t...

  14. Mortalidad intrahospitalaria por accidente cerebrovascular

    Directory of Open Access Journals (Sweden)

    Federico Rodríguez Lucci

    2013-08-01

    Full Text Available La mortalidad global por accidente cerebrovascular (ACV ha disminuido en las últimas tres décadas, probablemente debido a un mejor control de los factores de riesgo vascular. La mortalidad hospitalaria por ACV ha sido tradicionalmente estimada entre 6 y 14% en la mayoría de las series comunicadas. Sin embargo, los datos de ensayos clínicos recientes sugieren que esta cifra sería sustancialmente menor. Se revisaron datos de pacientes internados con diagnóstico de ACV del Banco de Datos de Stroke de FLENI y los registros institucionales de mortalidad entre los años 2000 y 2010. Los subtipos de ACV isquémicos se clasificaron según criterios TOAST y los ACV hemorrágicos en hematomas intrapanquimatosos, hemorragias subaracnoideas aneurismáticas, malformaciones arteriovenosas y otros hematomas intraparenquimatosos. Se analizaron 1514 pacientes, 1079 (71% con ACV isquémico (grandes vasos 39%, cardioembólicos 27%, lacunares 9%, etiología indeterminada 14%, otras etiologías 11% y 435 (29% con ACV hemorrágico (intraparenquimatosos 27%, hemorragia subaracnoidea 30%, malformaciones arteriovenosas 25% y otros hematomas espontáneos 18%. Se registraron 38 muertes intrahospitalarias (17 ACV isquémicos y 21 ACV hemorrágicos, representando una mortalidad global del 2.5% (1.7% en ACV isquémicos y 4.8% en ACV hemorrágicos. No se registraron muertes asociadas al uso de fibrinolíticos endovenosos. La mortalidad intrahospitalaria en pacientes con ACV isquémico y hemorrágico en nuestro centro fue baja. El manejo en un centro dedicado a las enfermedades neurológicas y el enfoque multidisciplinario por personal médico y no médico entrenado en el cuidado de la enfermedad cerebrovascular podrían explicar, al menos en parte, estos resultados.

  15. A synopsis of collective alpha effects and implications for ITER

    Energy Technology Data Exchange (ETDEWEB)

    Sigmar, D.J.

    1990-10-01

    This paper discusses the following: Alpha Interaction with Toroidal Alfven Eigenmodes; Alpha Interaction with Ballooning Modes; Alpha Interaction with Fishbone Oscillations; and Implications for ITER.

  16. Calibration of sources for alpha spectroscopy systems

    International Nuclear Information System (INIS)

    This paper describes the calibration methodology for measuring the total alpha activity of plane and thin sources with the Alpha Spectrometer for Silicon Detector in the Nuclear Measures and Dosimetry laboratory at IEAv/CTA. (author)

  17. Enzyme replacement therapy for alpha-mannosidosis

    DEFF Research Database (Denmark)

    Borgwardt, Line Gutte; Dali, Christine I.; Fogh, J;

    2013-01-01

    Alpha-mannosidosis (OMIM 248500) is a rare lysosomal storage disease (LSD) caused by alpha-mannosidase deficiency. Manifestations include intellectual disabilities, facial characteristics and hearing impairment. A recombinant human alpha-mannosidase (rhLAMAN) has been developed for weekly...

  18. Una plataforma MEMS para la medición in-situ y en tiempo real de la tensión/esfuerzo inducido electroquímicamente en el electrodo de una bateria de litio-ion

    OpenAIRE

    Barón, Sergio D.

    2015-01-01

    En este trabajo se reporta la primera demostración exitosa de las capacidades de sensado de una plataforma MEMS para la caracterización in-situ de los procesos de expansión/contracción reversible inducida electroquímicamente en electrodos de baterías de litio-ion (LIB). La plataforma consiste en un arreglo de membranas flexibles que cambian su forma dinámicamente debido al intercalado/expansión y extracción/contracción de litio. El cambio de curvatura de la membrana se mide por el principio d...

  19. Morfometría de la estría vascular y el órgano de Corti ante el daño por kanamicina

    Directory of Open Access Journals (Sweden)

    Sandra Rodríguez-Salgueiro

    2010-01-01

    Full Text Available Las alteraciones morfológicas que inducen los aminoglucósidos en la estría vascular han sido muy poco estudiadas hasta el momento. Esta estructura no sensorial desempeña un papel importante en la audición, al ser la responsable de la generación del potencial endococlear necesario para el funcionamiento de las células ciliadas ubicadas en el órgano de Corti. El objetivo de este trabajo fue estudiar los cambios temporales inducidos por kanamicina sobre las áreas de la estría vascular y del órgano de Corti. Se estudiaron cócleas de 17 ratas Wistar adultas sanas y sordas de 4, 8 y 16 semanas de sordera. La sordera se indujo por inyecciones intraperitoneales de kanamicina y furosemida. Los cortes histológicos se estudiaron por Microscopia Óptica de Alta Resolución, inclusión en resina Spurr, cortes semifinos en el plano horizontal y tinción con azul de Stevenel. Se midieron las áreas de la estría vascular y del órgano de Corti en las regiones apical, medial y basal de la cóclea. El tratamiento ototóxico provocó disminución de las áreas del órgano de Corti y de la estría vascular con respecto al grupo control. La disminución del área del órgano de Corti se observó en todos los grupos de animales sordos. El área del órgano de Corti fue menor a medida que aumentó el tiempo de sordera. Se detectó disminución del área de la estría vascular solo a las ocho y dieciséis semanas de sordera. La base de la cóclea fue la región más afectada, con disminución significativa de las dos áreas en todos los grupos de animales sordos. En la octava semana de sordera se dañaron las dos áreas en todas las regiones cocleares. De acuerdo con resultados previos de este grupo de trabajo, es también en la octava semana cuando se hace significativa la disminución de la densidad neuronal del ganglio espiral.

  20. Dabigatran como posibilidad terapéutica en el síndrome de trombocitopenia inducida por heparina tipo II Dabigatran as a therapeutic possibility in heparin-induced thrombocytopenia type II

    Directory of Open Access Journals (Sweden)

    F.J. Anniccherico

    2012-12-01

    Full Text Available El síndrome de trombocitopenia inducido por heparina (HIT con una incidencia del 0,2-0,5 % en pacientes expuestos a heparina durante más de 4 días, es producido por una alteración inmune con formación de anticuerpos frente al complejo heparina-factor 4 plaquetario, que presenta un amplio espectro de manifestaciones clínicas: siendo la trombocitopenia, los fenómenos trombóticos arteriales/venosos y la necrosis cutánea los más frecuentes. Hasta el momento actual, lepirudina, recientemente suspendida y argatroban (inhibidores directos de la trombina son los fármacos aprobados y habitualmente usados en el tratamiento, suministrados de forma parenteral. El dabigatran, un nuevo fármaco anticoagulante, inhibidor directo y reversible de la trombina teóricamente podría ser un fármaco empleado en el tratamiento del HIT. Según la bibliografía consultada presentamos el primer caso de HIT tratada con dabigatran en la literatura médica.The syndrome of heparin-induced thrombocytopenia (HIT, with an incidence of 0.2-0.5% in patients exposed to heparin for more than 4 days, is produced by an immune alteration with the formation of antibodies against the heparin platelet factor 4 complex. It presents a wide spectrum of clinical manifestations, the most frequent of which are thrombocytopenia, thrombotic arterial-venous phenomena, and cutaneous necrosis. Up to the present, lepiridin, recently suspended, and argatroban (direct thrombin inhibitors have been the approved medicines normally used in treatment, administered in parenteral form. Dabigatran, a new anticoagulant medicine that is a direct and reversible thrombin inhibitor, could theoretically be a medicine employed in treating HIT. According to the bibliography consulted we are presenting the first case of HIT treated with dabigatran in the medical literature.

  1. Miotoxicidade por organofosforados Organophosphate myotoxicity

    Directory of Open Access Journals (Sweden)

    Maria J. Cavaliere

    1996-06-01

    Full Text Available Os organofosforados são um grupo de compostos químicos amplamente utilizados em agropecuária como inseticidas, ocasionando intoxicações acidentais em animais e humanos, e mesmo sendo utilizados em tentativas de suicídio. A toxicidade desses produtos decorre sobretudo de insuficiência cárdio-respiratória por compromentimento do sistema nervoso autônomo. Sabe-se que alguns destes compostos induzem em animais de experimentação e em humanos, uma miopatia caracterizada por degeneração de células musculares, comprometendo sobretudo a musculatura respiratória. Baseado no fato de que este comprometimento contribui para a piora da função respiratória, propõe-se um protocolo de avaliação rotineira de miotoxicidade por compostos organofosforados, através de uma bateria mínima e suficiente de colorações e reações histoquímicas para quantificação da necrose muscular. Utilizaram-se como modelo experimental, grupos de ratos albinos (Wistar intoxicados com o organofosforado paraoxon, com e sem antídotos (atropina ou pralidoxima. Verificou-se nos grupos tratados com paraoxon e paraoxon mais atropina, necrose de fibras musculares no diafragma, que atingia em determinadas áreas até 15% das fibras. No grupo tratado com paraoxon mais pralidoxima, a necrose foi mínima, evidenciando o papel mioprotetor deste último antídoto.Organophosphates comprise a group of chemical compounds extensively used in farming as insecticides, which cause accidental poisoning in animals and men and are also used in suicide attempts. The toxicity of these compounds is due especially to the cardiac and respiratory impairment in consequence of autonomic nervous system disorders. However, it is known that some of these products induce a myopathy in experimental animals and humans. This myopathy is characterized by muscle cell degeneration, involving above all the respiratory muscles. Based on the fact that this involvement certainly enhances the

  2. Damped Lyman-Alpha Galaxies

    CERN Document Server

    Turnshek, D A; Lane, W; Monier, E M; Nestor, D; Bergeron, J; Briggs, F; Smette, A

    2000-01-01

    Some results from an imaging program to identify low-redshift (0.09alpha (DLA) galaxies are presented. The standard paradigm that was widely accepted a decade ago, that DLA galaxies are the progenitors of luminous disk galaxies, is now being seriously challenged. The indisputable conclusion from imaging studies at low redshift is that the morphological types of DLA galaxies are mixed and that they span a range in luminosities and surface brightnesses.

  3. Crystalline anhydrous {alpha},{alpha}-trehalose (polymorph {beta}) and crystalline dihydrate {alpha},{alpha}-trehalose: A calorimetric study

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Susana S. [Centro de Quimica Estrutural, Complexo Interdisciplinar, Instituto Superior Tecnico, 1049-001 Lisbon (Portugal)]. E-mail: susanapinto@ist.utl.pt; Diogo, Herminio P. [Centro de Quimica Estrutural, Complexo Interdisciplinar, Instituto Superior Tecnico, 1049-001 Lisbon (Portugal)]. E-mail: hdiogo@ist.utl.pt; Moura-Ramos, Joaquim J. [Centro de Quimica-Fisica Molecular, Complexo Interdisciplinar, Instituto Superior Tecnico, 1049-001 Lisbon (Portugal)]. E-mail: mouraramos@ist.utl.pt

    2006-09-15

    The mean values of the standard massic energy of combustion of crystalline anhydrous {alpha},{alpha}-trehalose (C{sub 12}H{sub 22}O{sub 11}, polymorph {beta}) and crystalline dihydrate {alpha},{alpha}-trehalose (C{sub 12}H{sub 26}O{sub 13}) measured by static-bomb combustion calorimetry in oxygen, at the temperature T=298.15K, are {delta}{sub c}u{sup o}=-(16434.05+/-4.50)J.g{sup -1} and {delta}{sub c}u{sup o}=-(14816.05+/-3.52)J.g{sup -1}, respectively. The standard (p{sup o}=0.1MPa) molar enthalpy of formation of these compounds were derived from the corresponding standard molar enthalpies of combustion, respectively, {delta}{sub f}H{sub m}{sup o} (C{sub 12}H{sub 22}O{sub 11},cr)=-(2240.9+/-3.9)kJ.mol{sup -1}, and {delta}{sub f}H{sub m}{sup o} (C{sub 12}H{sub 26}O{sub 13},cr)=-(2832.6+/-3.6)kJ.mol{sup -1}. The values of the standard enthalpies of formation obtained in this work, together with data on enthalpies of solution at infinite dilution ({delta}{sub sol}H{sup {approx}}) for crystalline dihydrate and amorphous anhydrous trehalose, allow a better insight on the thermodynamic description of the trehalose system which can provide, together with the future research on the subject, a contribution for understanding the metabolism in several organisms, as well as the phase transition between the different polymorphs.

  4. Reprogramación celular de embriones de Anthurium andraeanum por fitohormonas para micropropagación masiva

    Directory of Open Access Journals (Sweden)

    Julieta Mireles-Ordaz

    2015-01-01

    Full Text Available El género Anthurium incluye alrededor de 800 especies, las cuales son originarias de diversos países tropicales y subtropicales de América. Numerosos cultivos de estas especies de Anthurium son crecidos y comercializados debido a su gran popularidad como plantas ornamentales alrededor de todo el mundo, de las cuales la más popular es Anthurium andreanum. La reproducción sexual de estas plantas en invernaderos es difícil y toma mucho tiempo, lo cual representa una desventaja para su producción masiva y comercialización. La micropropagación in vitro ha emergido como una opción para sobrellevar dicha desventaja, hasta la fecha se han logrado avances parcialmente exitosos en la micropropagación en especies de Anthurium usando varios tejidos como explantes iniciales, incluyendo hojas, pecíolo, espádice, espata, brote lateral, meristemo apical y embriones somáticos, estos últimos previamente inducidos a partir de tejido diferenciado. Sin embargo, hasta ahora no hay reportes del uso de embriones cigóticos como tejido madre para la propagación masiva de estas plantas. En el presente estudio reportamos la formación de callos organogénicos a partir de embriones cigóticos inmaduros crecidos en medio MS suplementado con la combinación de 2 mg/l de ácido 2,4-diclorofenoxiacético (2,4-D y 0.5 mg/l de 6-benzilamino-purina (BAP. Los resultados obtenidos demuestran que los embriones en proceso de desarrollo son altamente eficientes como explantes de origen para inducir la formación de tejido calloso de una manera rápida y fácil, dando en promedio 9 brotes por callo y logrando una taza de sobrevivencia de las plantas del 90% en la fase de aclimatación.

  5. Alpha voltaic batteries and methods thereof

    Science.gov (United States)

    Raffaelle, Ryne P. (Inventor); Jenkins, Phillip (Inventor); Wilt, David (Inventor); Scheiman, David (Inventor); Chubb, Donald (Inventor); Castro, Stephanie (Inventor)

    2011-01-01

    An alpha voltaic battery includes at least one layer of a semiconductor material comprising at least one p/n junction, at least one absorption and conversion layer on the at least one layer of semiconductor layer, and at least one alpha particle emitter. The absorption and conversion layer prevents at least a portion of alpha particles from the alpha particle emitter from damaging the p/n junction in the layer of semiconductor material. The absorption and conversion layer also converts at least a portion of energy from the alpha particles into electron-hole pairs for collection by the one p/n junction in the layer of semiconductor material.

  6. The Behaviour of Varying-Alpha Cosmologies

    CERN Document Server

    Barrow, John D; Magueijo, J

    2002-01-01

    We determine the behaviour of a time-varying fine structure 'constant' $\\alpha (t)$ during the early and late phases of universes dominated by the kinetic energy of changing $\\alpha (t)$, radiation, dust, curvature, and lambda, respectively. We show that after leaving an initial vacuum-dominated phase during which $\\alpha$ increases, $\\alpha$ remains constant in universes like our own during the radiation era, and then increases slowly, proportional to a logarithm of cosmic time, during the dust era. If the universe becomes dominated by negative curvature or a positive cosmological constant then $\\alpha$ tends rapidly to a constant value. The effect of an early period of de Sitter or power-law inflation is to drive $\\alpha$ to a constant value. Various cosmological consequences of these results are discussed with reference to recent observational studies of the value of $\\alpha$ from quasar absorption spectra and to the existence of life in expanding universes.

  7. Implication of the E. coli K12 uvrA and recA genes in the repair of 8-methoxypsoralen-induced mono adducts and crosslinks on plasmid DNA; Implicacion de los genes uvrA de E. coli K12 en la reparacion de monoaductos y entrecruzamien tos inducidos en DNA plasmidico por 8-metoxipso raleno mas luz ultravioleta A

    Energy Technology Data Exchange (ETDEWEB)

    Paramio, J.M.; Bauluz, C.; Vidania, R. de

    1986-07-01

    Genotoxicity of psoralen damages on plasmid DNA has been studied. pBR322 DNA was randomly modified with several concentrations of 8-methoxypsoralen plus 365 nm-UV light. After transformation into E. coli strains (wild-type, uvrA and recA) plasmid survival and mutagenesis were analyzed. To study the influence of the SOS response on plasmid recovery, preirradiation of the cells was performed. In absence of cell preirradiation, crosslinks were not repaired in any strain. Mono adducts were also lethal but in part removed by the excision-repair pathway. Preirradiation of the cells significantly. increased plasmid recovery in recA+ celia. In uvrA- only the mutagenic pathway seemed to be involved in the repair of the damaged DNA. Wild type strain showed the highest increase in plasmid survival, involving the repair of mono adducts and some fraction of crosslinks mainly through an error-free repair pathway. This suggests an enhancement of the excision repair promoted by the induction of SOS functions. (Author) 32 refs.

  8. Evidence about chlorophyllin can function as an inhibitor or promoter of induced genetic damage by gamma radiation in Drosophila somatic cells; Evidencia de que la clorofilina puede funcionar como un inhibidor o un promotor del dano genetico inducido por radiacion gamma en celulas somaticas de Drosophila

    Energy Technology Data Exchange (ETDEWEB)

    Pimentel, A.E.; Cruces, M.P.; Zimmering, S.I. [Departamento de Biologia, ININ, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2000-07-01

    The irradiation of the individuals that had been feed during 24 hours with a chlorophyllin solution at 5 % was delayed from 0 until 4 days. The protector effect of chlorophyllin persisted by 3 days and it appears to coincide with the stage when stopping the mitotic divisions in the imagal disk. Within of the same cellular population, it was demonstrated that chlorophyllin can function as an inhibitor, in the case of simple stains mwh or a potentiator in the case of twin stains and the flr type stains. It was planned an explanation for these results. (Author)

  9. Double-real corrections at O(alpha alpha_s) to single gauge boson production

    CERN Document Server

    Bonciani, Roberto; Mondini, Roberto; Vicini, Alessandro

    2016-01-01

    We consider the O(alpha alpha_s) corrections to single on-shell gauge boson production at hadron colliders. We concentrate on the contribution of all the subprocesses where the gauge boson is accompanied by the emission of two additional real partons and we evaluate the corresponding total cross sections. The latter are divergent quantities, because of soft and collinear emissions, and are expressed as Laurent series in the dimensional regularization parameter. The total cross sections are evaluated by means of reverse unitarity, i.e. expressing the phase-space integrals in terms of two-loop forward box integrals with cuts on the final state particles. The results are reduced to a combination of Master Integrals, which eventually are evaluated in terms of Generalized Polylogarithms. The presence of internal massive lines in the Feynman diagrams, due to the exchange of electroweak gauge bosons, causes the appearance of 14 Master Integrals which were not previously known in the literature and have been evaluate...

  10. Folding model study of the elastic $\\alpha + \\alpha$ scattering at low energies

    CERN Document Server

    Tan, Ngo Hai; Khoa, Dao T

    2014-01-01

    The folding model analysis of the elastic $\\alpha + \\alpha$ scattering at the incident energies below the reaction threshold of 34.7 MeV (in the lab system) has been done using the well-tested density dependent versions of the M3Y interaction and realistic choices for the $^4$He density. Because the absorption is negligible at the energies below the reaction threshold, we were able to probe the $\\alpha + \\alpha$ optical potential at low energies quite unambiguously and found that the $\\alpha + \\alpha$ overlap density used to construct the density dependence of the M3Y interaction is strongly distorted by the Pauli blocking. This result gives possible explanation of a long-standing inconsistency of the double-folding model in its study of the elastic $\\alpha + \\alpha$ and $\\alpha$-nucleus scattering at low energies using the same realistic density dependent M3Y interaction.

  11. The 2009 Wolrd Average of $\\alpha_s (M_Z)$

    CERN Document Server

    Bethke, Siegfried

    2009-01-01

    Measurements of $\\alpha_s$, the coupling strength of the Strong Interaction between quarks and gluons, are summarised and an updated value of the world average of $\\alpha_s (M_Z)$ is derived. Building up on previous reviews, special emphasis is laid on the most recent determinations of $\\alpha_s$. These are obtained from $\\tau$-decays, from global fits of electroweak precision data and from measurements of the proton structure function $\\F_2$, which are based on perturbative QCD calculations up to $O(\\alpha_s^4)$; from hadronic event shapes and jet production in $\\epem$ annihilation, based on $O(\\alpha_s^3) $ QCD; from jet production in deep inelastic scattering and from $\\Upsilon$ decays, based on $O(\\alpha_s^2) $ QCD; and from heavy quarkonia based on unquenched QCD lattice calculations. Applying pragmatic methods to deal with possibly underestimated errors and/or unknown correlations, the world average value of $\\alpha_s (M_Z)$ results in $\\alpha_s (M_Z) = 0.1184 \\pm 0.0007$. The measured values of $\\alpha...

  12. Synthesis of 16 alpha-3H androgen and estrogen substrates for 16 alpha-hydroxylase.

    Science.gov (United States)

    Cantineau, R; Kremers, P; De Graeve, J; Cornelis, A; Laszlo, P; Gielen, J E; Lambotte, R

    1981-02-01

    The synthesis of 16 alpha-3H androgens and estrogens is described. 1-(3H)-Acetic acid in the presence of zinc dust reacts with 16 alpha-bromo-17-ketosteroids to produce 16 alpha-3H-17-ketosteroids. This chemical reaction was used to prepare 16 alpha-3H-dehydroepiandrosterone (I) and 16 alpha-3H-estrone acetate (XI) from 16 alpha-bromo-dehydroepiandrosterone (X) and from 16 alpha-bromo-estrone acetate (XII), respectively. Using appropriate microbiological techniques, it was possible to convert these radiolabelled substrates into 16 alpha-3H-androstenedione (II) and 16 alpha-3H-estradiol-17 beta (VII). 16 alpha-3H-Estrone (VI) was obtained by the chemical hydrolysis of 16 alpha-3H-estrone acetate. The label distribution as determined by microbiological 16 alpha-hydroxylations indicated a specific labelling of 77% for androgens and 65% for estrogens in the 16 alpha position. These substrates can be used for measuring the 16 alpha hydroxylase activity, an important step in the biosynthesis of estriol (VIII) and estetrol (IX). PMID:7013160

  13. Recoil-alpha-fission and recoil-alpha-alpha-fission events observed in the reaction Ca-48 + Am-243

    CERN Document Server

    Forsberg, U; Andersson, L -L; Di Nitto, A; Düllmann, Ch E; Gates, J M; Golubev, P; Gregorich, K E; Gross, C J; Herzberg, R -D; Hessberger, F P; Khuyagbaatar, J; Kratz, J V; Rykaczewski, K; Sarmiento, L G; Schädel, M; Yakushev, A; Åberg, S; Ackermann, D; Block, M; Brand, H; Carlsson, B G; Cox, D; Derkx, X; Dobaczewski, J; Eberhardt, K; Even, J; Fahlander, C; Gerl, J; Jäger, E; Kindler, B; Krier, J; Kojouharov, I; Kurz, N; Lommel, B; Mistry, A; Mokry, C; Nazarewicz, W; Nitsche, H; Omtvedt, J P; Papadakis, P; Ragnarsson, I; Runke, J; Schaffner, H; Schausten, B; Shi, Y; Thörle-Pospiech, P; Torres, T; Traut, T; Trautmann, N; Türler, A; Ward, A; Ward, D E; Wiehl, N

    2015-01-01

    Products of the fusion-evaporation reaction Ca-48 + Am-243 were studied with the TASISpec set-up at the gas-filled separator TASCA at the GSI Helmholtzzentrum f\\"ur Schwerionenforschung. Amongst the detected thirty correlated alpha-decay chains associated with the production of element Z=115, two recoil-alpha-fission and five recoil-alpha-alpha-fission events were observed. The latter are similar to four such events reported from experiments performed at the Dubna gas-filled separator. Contrary to their interpretation, we propose an alternative view, namely to assign eight of these eleven decay chains of recoil-alpha(-alpha)-fission type to start from the 3n-evaporation channel 115-288. The other three decay chains remain viable candidates for the 2n-evaporation channel 115-289.

  14. La inconstitucionalidad por omisión

    Directory of Open Access Journals (Sweden)

    Luz Bulnes Aldunate

    2006-01-01

    Full Text Available El artículo analiza la facultad de los tribunales constitucionales para determinar la inconstitucionalidad por omisión, en virtud del silencio u omisión de la autoridad de normar un principio o regla constitucional dispuesto por la Constitución explícita o implícitamente.

  15. The Alpha Magnetic Spectrometer (AMS)

    Energy Technology Data Exchange (ETDEWEB)

    Alcaraz, J.; Alpat, B.; Ambrosi, G.; Anderhub, H.; Ao, L.; Arefiev, A.; Azzarello, P.; Babucci, E.; Baldini, L.; Basile, M.; Barancourt, D.; Barao, F.; Barbier, G.; Barreira, G.; Battiston, R.; Becker, R.; Becker, U.; Bellagamba, L.; Bene, P.; Berdugo, J.; Berges, P.; Bertucci, B.; Biland, A.; Bizzaglia, S.; Blasko, S.; Boella, G.; Boschini, M.; Bourquin, M.; Brocco, L.; Bruni, G.; Buenerd, M.; Burger, J.D.; Burger, W.J.; Cai, X.D.; Camps, C.; Cannarsa, P.; Capell, M.; Casadei, D.; Casaus, J.; Castellini, G.; Cecchi, C.; Chang, Y.H.; Chen, H.F.; Chen, H.S.; Chen, Z.G.; Chernoplekov, N.A.; Chiueh, T.H.; Chuang, Y.L.; Cindolo, F.; Commichau, V.; Contin, A. E-mail: contin@bo.infn.it; Crespo, P.; Cristinziani, M.; Cunha, J.P. da; Dai, T.S.; Deus, J.D.; Dinu, N.; Djambazov, L.; DAntone, I.; Dong, Z.R.; Emonet, P.; Engelberg, J.; Eppling, F.J.; Eronen, T.; Esposito, G.; Extermann, P.; Favier, J.; Fiandrini, E.; Fisher, P.H.; Fluegge, G.; Fouque, N.; Galaktionov, Yu.; Gervasi, M.; Giusti, P.; Grandi, D.; Grimm, O.; Gu, W.Q.; Hangarter, K.; Hasan, A.; Hermel, V.; Hofer, H.; Huang, M.A.; Hungerford, W.; Ionica, M.; Ionica, R.; Jongmanns, M.; Karlamaa, K.; Karpinski, W.; Kenney, G.; Kenny, J.; Kim, W.; Klimentov, A.; Kossakowski, R.; Koutsenko, V.; Kraeber, M.; Laborie, G.; Laitinen, T.; Lamanna, G.; Laurenti, G.; Lebedev, A.; Lee, S.C.; Levi, G.; Levtchenko, P.; Liu, C.L.; Liu, H.T.; Lopes, I.; Lu, G.; Lu, Y.S.; Luebelsmeyer, K.; Luckey, D.; Lustermann, W.; Mana, C.; Margotti, A.; Mayet, F.; McNeil, R.R.; Meillon, B.; Menichelli, M.; Mihul, A.; Mourao, A.; Mujunen, A.; Palmonari, F.; Papi, A.; Park, I.H.; Pauluzzi, M.; Pauss, F.; Perrin, E.; Pesci, A.; Pevsner, A.; Pimenta, M.; Plyaskin, V.; Pojidaev, V.; Postolache, V.; Produit, N.; Rancoita, P.G.; Rapin, D.; Raupach, F.; Ren, D.; Ren, Z.; Ribordy, M.; Richeux, J.P.; Riihonen, E.; Ritakari, J.; Roeser, U.; Roissin, C.; Sagdeev, R.; Sartorelli, G.; Schultz von Dratzig, A.; Schwering, G.; Scolieri, G.; Seo, E.S.; Shoutko, V.

    2002-02-01

    The Alpha Magnetic Spectrometer (AMS) is a large acceptance (0.65 sr m{sup 2}) detector designed to operate in the International Space Station (ISS) for three years. The purposes of the experiment are to search for cosmic antimatter and dark matter and to study the composition and energy spectrum of the primary cosmic rays. A 'scaled-down' version has been flown on the Space Shuttle Discovery for 10 days in June 1998. The complete AMS is programmed for installation on the ISS in October 2003 for an operational period of 3 yr. This contribution reports on the experimental configuration that will be installed on the ISS.

  16. The Alpha Magnetic Spectrometer (AMS)

    CERN Document Server

    Alcaraz, J; Ambrosi, G; Anderhub, H; Ao, L; Arefev, A; Azzarello, P; Babucci, E; Baldini, L; Basile, M; Barancourt, D; Barão, F; Barbier, G; Barreira, G; Battiston, R; Becker, R; Becker, U; Bellagamba, L; Bene, P; Berdugo, J; Berges, P; Bertucci, B; Biland, A; Bizzaglia, S; Blasko, S; Bölla, G; Boschini, M; Bourquin, Maurice; Brocco, L; Bruni, G; Buénerd, M; Burger, J D; Burger, W J; Cai, X D; Camps, C; Cannarsa, P; Capell, M; Casadei, D; Casaus, J; Castellini, G; Cecchi, C; Chang, Y H; Chen, H F; Chen, H S; Chen, Z G; Chernoplekov, N A; Tzi Hong Chiueh; Chuang, Y L; Cindolo, F; Commichau, V; Contin, A; Crespo, P; Cristinziani, M; Cunha, J P D; Dai, T S; Deus, J D; Dinu, N; Djambazov, L; Dantone, I; Dong, Z R; Emonet, P; Engelberg, J; Eppling, F J; Eronen, T; Esposito, G; Extermann, P; Favier, Jean; Fiandrini, E; Fisher, P H; Flügge, G; Fouque, N; Galaktionov, Yu; Gervasi, M; Giusti, P; Grandi, D; Grimm, O; Gu, W Q; Hangarter, K; Hasan, A; Hermel, V; Hofer, H; Huang, M A; Hungerford, W; Ionica, M; Ionica, R; Jongmanns, M; Karlamaa, K; Karpinski, W; Kenney, G; Kenny, J; Kim, W; Klimentov, A; Kossakowski, R; Koutsenko, V F; Kraeber, M; Laborie, G; Laitinen, T; Lamanna, G; Laurenti, G; Lebedev, A; Lee, S C; Levi, G; Levchenko, P M; Liu, C L; Liu, H T; Lopes, I; Lu, G; Lü, Y S; Lübelsmeyer, K; Luckey, D; Lustermann, W; Maña, C; Margotti, A; Mayet, F; McNeil, R R; Meillon, B; Menichelli, M; Mihul, A; Mourao, A; Mujunen, A; Palmonari, F; Papi, A; Park, I H; Pauluzzi, M; Pauss, Felicitas; Perrin, E; Pesci, A; Pevsner, A; Pimenta, M; Plyaskin, V; Pozhidaev, V; Postolache, V; Produit, N; Rancoita, P G; Rapin, D; Raupach, F; Ren, D; Ren, Z; Ribordy, M; Richeux, J P; Riihonen, E; Ritakari, J; Röser, U; Roissin, C; Sagdeev, R; Sartorelli, G; Schwering, G; Scolieri, G; Seo, E S; Shoutko, V; Shoumilov, E; Siedling, R; Son, D; Song, T; Steuer, M; Sun, G S; Suter, H; Tang, X W; Ting, Samuel C C; Ting, S M; Tornikoski, M; Torsti, J; Ulbricht, J; Urpo, S; Usoskin, I; Valtonen, E; Vandenhirtz, J; Velcea, F; Velikhov, E P; Verlaat, B; Vetlitskii, I; Vezzu, F; Vialle, J P; Viertel, Gert M; Vitè, Davide F; Gunten, H V; Wallraff, W; Wang, B C; Wang, J Z; Wang, Y H; Wiik, K; Williams, C; Wu, S X; Xia, P C; Yan, J L; Yan, L G; Yang, C G; Yang, M; Ye, S W; Yeh, P; Xu, Z Z; Zhang, H Y; Zhang, Z P; Zhao, D X; Zhu, G Y; Zhu, W Z; Zhuang, H L; Zichichi, A; Zimmermann, B

    2002-01-01

    The Alpha Magnetic Spectrometer (AMS) is a large acceptance (0.65 sr m sup 2) detector designed to operate in the International Space Station (ISS) for three years. The purposes of the experiment are to search for cosmic antimatter and dark matter and to study the composition and energy spectrum of the primary cosmic rays. A 'scaled-down' version has been flown on the Space Shuttle Discovery for 10 days in June 1998. The complete AMS is programmed for installation on the ISS in October 2003 for an operational period of 3 yr. This contribution reports on the experimental configuration that will be installed on the ISS.

  17. Linearized Bekenstein Varying Alpha Models

    CERN Document Server

    Pina-Avelino, P; Oliveira, J C

    2004-01-01

    We study the simplest class of Bekenstein-type, varying $\\alpha$ models, in which the two available free functions (potential and gauge kinetic function) are Taylor-expanded up to linear order. Any realistic model of this type reduces to a model in this class for a certain time interval around the present day. Nevertheless, we show that no such model is consistent with all existing observational results. We discuss possible implications of these findings, and in particular clarify the ambiguous statement (often found in the literature) that ``the Webb results are inconsistent with Oklo''.

  18. Orthopositronium lifetime at O({alpha}) and O({alpha}{sup 3} ln {alpha}) in closed form

    Energy Technology Data Exchange (ETDEWEB)

    Kniehl, B.A.; Kotikov, A.V.; Veretin, O.L. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    2009-09-15

    Recently, the O({alpha}) and O({alpha}{sup 3} ln{alpha}) radiative corrections to the orthopositronium lifetime have been presented in closed analytical form, in terms of basic irrational numbers that can be evaluated numerically to arbitrary precision [Phys. Rev. Lett. 101, 193401 (2008)]. Here, we present the details of this calculation and reveal the nature of these new constants. We also list explicit transformation formulas for generalized polylogarithms of weight four, which may be useful for other applications. (orig.)

  19. Verdad por definición

    Directory of Open Access Journals (Sweden)

    Garrido Garrido, Julián

    1997-07-01

    Full Text Available Not available.La verdad por definición es un tipo peculiar de verdad científica, distinguible de las verdades lógicas, matemáticas y empíricas. La definición, por su parte, designa diversos procedimientos de asignación de significado, cuyas diferencias exigen una adjetivación cuidadosa: definiciones ostensivas y operacionales, definiciones de diccionario y definiciones teóricas. Pero sólo las del último tipo son verdaderas por definición. En el presente artículo se precisa el concepto formal de definición teórica, se delimita la estructura de esos enunciados, se analiza la verdad por definición, y se comparan, por último, las definiciones teóricas con los otros tipos de definición.

  20. Generación de nuevos ecosistemas litorales por albardones de relleno en la costa de la ciudad de Buenos Aires

    Directory of Open Access Journals (Sweden)

    Silvia C. Marcomini

    2004-06-01

    Full Text Available Buenos Aires, la ciudad más poblada de la Argentina se encuentra en la margen sudeste del estuario del río de la Plata. La costa actual es el resultado de numerosas tareas de relleno artificial que dieron lugar a la progradación de la ribera desde el año 1836. El principal objetivo de estas tareas de relleno siempre fue ganar terreno a las aguas del estuario, como resultado de una política de expansión. Se estimó que durante los últimos 162 años se produjo un relleno artificial de 12,67 hectáreas por año, con una progradación costera variable entre los 400 y 1000 metros. El trabajo plantea un nueva visión para la planificación y manejo de la costa teniendo en cuenta la importancia que tiene el tipo y configuración del albardón de relleno en la generación de nuevos ecosistemas inducidos. Se analizó la evolución costera de los últimos 40 años asociada a cuatro tipos de modelos de albardones de relleno: tipo bahía, cabo, barrera y espiga. El tipo bahía indujo la acumulación costera mediante la progradación de una planicie estuárica. Los albardones de tipo cabos dieron lugar a la formación de lagos y pantanos aislados de la hidrodinámica del estuario que por lo general tendieron a incrementar su acreción vertical por efecto del crecimiento de la vegetación. Los diseños de tipo barrera y espiga generaron una laguna artificial dominada por la acción del las mareas y por las variaciones del nivel del río inducidas por cambios en las direcciones de los vientos. Asimismo se registró un tendencia hacia la colmatación con generación de morfologías tales como planicies de marea, marismas de agua dulce y canales de marea. En la diagramación del diseño de un albardón de relleno debe considerarse como objetivo no solo ganar terreno al río sino que también el tipo de ecosistema que se generará asociado a dichas estructuras. Los nuevos ecosistemas generados deben ser cuidadosamente planificados y manejados por las

  1. Evolution of NADPH-cytochrome P450 oxidoreductases (POR) in Apiales - POR 1 is missing

    DEFF Research Database (Denmark)

    Andersen, Trine Bundgaard; Hansen, Niels Bjørn; Laursen, Tomas;

    2016-01-01

    The NADPH-dependent cytochrome P450 oxidoreductase (POR) is the obligate electron donor to eukaryotic microsomal cytochromes P450 enzymes. The number of PORs within plant species is limited to one to four isoforms, with the most common being two PORs per plant. These enzymes provide electrons to ...

  2. Resonances in alpha-nuclei interaction

    Energy Technology Data Exchange (ETDEWEB)

    Karpeshin, F F [Fock Institute of Physics, St Petersburg State University, RU-198504 St Petersburg (Russian Federation); La Rana, G [Instituto Nazionale di Fisica Nucleare and Dipartimento di Scienze Fisiche dell' Universita di Napoli, Monte S. Angelo, via Cintia, 80126 Naples (Italy); Vardaci, Emanuele [Instituto Nazionale di Fisica Nucleare and Dipartimento di Scienze Fisiche dell' Universita di Napoli, Monte S. Angelo, via Cintia, 80126 Naples (Italy); Brondi, Augusto [Instituto Nazionale di Fisica Nucleare and Dipartimento di Scienze Fisiche dell' Universita di Napoli, Monte S. Angelo, via Cintia, 80126 Naples (Italy); Moro, Renata [Instituto Nazionale di Fisica Nucleare and Dipartimento di Scienze Fisiche dell' Universita di Napoli, Monte S. Angelo, via Cintia, 80126 Naples (Italy); Abramovich, S N [Russian Federal Nuclear Centre VNIIEF, RU-607190 Sarov, Nizhny Novgorod Region (Russian Federation); Serov, V I [Russian Federal Nuclear Centre VNIIEF, RU-607190 Sarov, Nizhny Novgorod Region (Russian Federation)

    2007-03-15

    Tunnelling of {alpha} particles through the Coulomb barrier is considered. The main attention is given to the effect of sharp peaks arising in the case of coincidence of the {alpha} energy with that of a quasistaionary state within the barrier. The question of the {alpha}-nucleus potential is discussed in this light. The method is applied to the {alpha} decay of a compound nucleus of {sup 135}Pr. The appearance of the peaks in the spectrum of emitted particles is predicted. They can give rise to 'anomalous' properties of some neutron resonances. The peaks can also be observed in the incoming {alpha}-nucleus channel. Observation of the peaks would give unique information about the {alpha}-nucleus potential.

  3. Confidence Intervals for Cronbach's Coefficient Alpha Values

    OpenAIRE

    Koning, Alex; Franses, Philip Hans

    2003-01-01

    textabstractCoefficient Alpha, which is widely used in empirical research, estimates the reliability of a test consisting of parallel items. In practice it is difficult to compare values of alpha across studies as it depends on the number of items used. In this paper we provide a simple solution, which amounts to computing the confidence intervals of an alpha, as these intervals automatically account for differences across the numbers of items. We also give appropriate statistics to test for ...

  4. Confidence Intervals for Cronbach's Coefficient Alpha Values

    OpenAIRE

    Koning, A. J.; Franses, Ph.H.B.F.

    2003-01-01

    Coefficient Alpha, which is widely used in empirical research, estimates the reliability of a test consisting of parallel items. In practice it is difficult to compare values of alpha across studies as it depends on the number of items used. In this paper we provide a simple solution, which amounts to computing the confidence intervals of an alpha, as these intervals automatically account for differences across the numbers of items. We also give appropriate statistics to test for significant ...

  5. Conformons in alpha-helical proteins

    CERN Document Server

    Atanasov, Victor

    2009-01-01

    We propose the conformon as a quantum of conformational change for energy transfer in alpha-helical proteins. The underlying mechanism of interaction between the quantum of excitation and the conformational degrees of freedom is nonlinear and leads to solitary wave packets of conformational energy. The phenomenon is specific to alpha-helices and not to beta-sheets in proteins due to the three strands of hydrogen bonds constituting the alpha-helical backbone.

  6. Quantum time scales in alpha tunneling

    CERN Document Server

    Kelkar, N G; Nowakowski, M

    2008-01-01

    The theoretical treatment of alpha decay by Gamow is revisited by investigating the quantum time scales in tunneling. The time spent by an alpha particle in front of the barrier and traversing it before escape is evaluated using microscopic alpha nucleus potentials. The half-life of a nucleus is shown to correspond to the time spent by the alpha knocking in front of the barrier. Calculations for medium and super heavy nuclei show that from a multitude of available tunneling time definitions, the transmission dwell time gives the bulk of the lifetime of the decaying state, in most cases.

  7. [Alpha-linolenic acid and cardiovascular diseases].

    Science.gov (United States)

    Ristić-Medić, Danijela; Ristić, Gordana; Tepsić, Vesna

    2003-01-01

    IMPORTANCE AND METABOLISM OF ALPHA-LINOLENIC ACID: Alpha-linolenic acid is an essential fatty acid which cannot be produced in the body and must be taken by food. Both in animals and humans, alpha-linolenic acid is desaturated and elongated into eicosapentaenoic and docosahexaenoic acid. It is also incorporated into plasma and tissue lipids and its conversion is affected by levels of linoleic acid. POTENTIAL ROLE IN PATHOGENESIS OF CARDIOVASCULAR DISEASES: Diet enriched in n-3 fatty acids, especially alpha-linolenic acid, reduces the incidence of cardiac death. Studies have shown that alpha linolenic acid prevents ventricular fibrillation which is the main cause of cardiac death. Studies in rats suggest that alpha-linolenic acid may be more effective in preventing ventricular fibrillations than eicosapentaenoic and docosahexaenoic acid. Furthermore, alpha-linolenic acid is the main fatty acid decreasing platalet aggregation which is an important step in thrombosis i.e. non-fatal myocardial infarction and stroke. DIETARY SOURCES AND NUTRITION RECOMMENDATIONS: Dietary sources include flaxseed and flaxseed oil, canola oil, soybean and soybean oil, pumpkin seed and pumpkin oil, walnuts and walnut oil. Strong evidence supports beneficial effects of alpha-linolenic acid and its dietary sources should be incorporated into balanced diet for prevention of cardiovascular diseases. The recommended daily intake is 2 g with a ratio of 5/1 for linoleic/alpha-linolenic acid. PMID:15510909

  8. Quantum Estimates of Alpha Emitter Life Time

    Directory of Open Access Journals (Sweden)

    B. Santoso

    2006-01-01

    Full Text Available Quantum estimates of several alpha radioactive life time have been made using the probability of quantum tunneling through the nuclear potential barrier. It is assumed that for a given nucleus with mass number A and isotopic number Z, there exists an alpha particle moving freely back and forth in the nucleus with mass and isotopic numbers A -4 and Z-2. If the probability of penetrating the nuclear potential barrier is Τ, then after N times (N=1/Τ hitting the barrier an alpha particle is emitted. To obtain the elapsed time for emitting an alpha particle requires N times τ0, where τ0 is the time travel for alpha across the nuclear diameter, which is dependent on alpha energy. It is assumed here that this kinetic energy is the same as the emitted energy. The emitting alpha kinetic energies here are calculated by the difference of the masses of the parent and daughter nuclei and the alpha particles. They are in closed agreement with the experimental observations. While the alpha radioactive life time are not the same order of magnitudes but give the same linearity on the logarithmic scale as function of the inverse square root of energy.

  9. Trastornos tiroideos por amiodarona The effects of amiodarone on the thyroid

    Directory of Open Access Journals (Sweden)

    M. Toni

    2009-12-01

    Full Text Available Fundamento. Muchos pacientes reciben tratamiento con amiodarona por su eficacia como antiarrítmico. Aproximadamente el 16% desarrollan alteraciones de la función tiroidea. El objetivo de este estudio es valorar la relevancia de dichas alteraciones en la población navarra, estudiada entre 2001 y 2007. Material y métodos. Se trata de un estudio retrospectivo, en el que se han analizado las características de 182 pacientes remitidos a la consulta de endocrinología, por desarrollar disfunción tiroidea mientras se encontraban en tratamiento con amiodarona. Para ello se han medido en plasma los niveles de hormonas tiroideas y anticuerpos antitiroideos y, cuando ha sido necesario, se ha realizado estudio tiroideo de imagen, ya sea mediante gammagrafía con tecnecio 99 o ecografía. Resultados. El screening de la función tiroidea, recomendado previamente al inicio de tratamiento con amiodarona, se efectúo solamente en el 20,9% de los pacientes estudiados. El 41% presentaban hipotiroidismo; de éstos, en el 76% se suspendió el tratamiento con amiodarona. El tiempo medio de aparición del mismo fue de 21 ±12 meses desde el inicio de la toma del fármaco. El 48,6% desarrolló hipotiroidismo permanente. Este grupo presentaba niveles de TSH (tirotropina mayores y llevaban menos tiempo de tratamiento con amiodarona. El 59% presentaban tirotoxicosis: el 59,4% presentó una tirotoxicosis inducida por amiodarona (TIA tipo 1, el 30,6% una TIA tipo 2 y el 10% restante fue etiquetada de tiroxicosis mixta. El tiempo medio de aparición de la tirotoxicosis fue de 29,5 meses desde el inicio del tratamiento. Los niveles de T4 libre eran significativamente mayores en la TIA tipo 2. Todos los pacientes fueron tratados con antitiroideos y/o corticoides, llegando a precisar en alguna ocasión ingreso hospitalario debido a la severidad del cuadro. Conclusiones. En nuestra serie son más frecuentes las tirotoxicosis que el hipotiroidismo inducido por amiodarona

  10. $\\alpha_{s}$ from the (revised) ALEPH data for $\\tau$ decay

    CERN Document Server

    Boito, Diogo; Maltman, Kim; Osborne, James; Peris, Santiago

    2014-01-01

    We present a new analysis of $\\alpha_s$ from hadronic $\\tau$ decays based on the recently revised ALEPH data. The analysis is based on a strategy which we previously applied to the OPAL data. We critically compare our strategy to the one traditionally used and comment on the main differences. Our analysis yields the values $\\alpha_s(m_\\tau^2)=0.296\\pm 0.010$ using fixed-order perturbation theory, and $\\alpha_s(m_\\tau^2)=0.310\\pm 0.014$ using contour-improved perturbation theory. Averaging these values with our previously obtained values from the OPAL data, we find $\\alpha_s(m_\\tau^2)=0.303\\pm 0.009$, respectively, $\\alpha_s(m_\\tau^2)=0.319\\pm 0.012$, as the most reliable results for $\\alpha_s$ from $\\tau$ decays currently available.

  11. Verdad por definición

    OpenAIRE

    Garrido Garrido, Julián

    1997-01-01

    Not available.La verdad por definición es un tipo peculiar de verdad científica, distinguible de las verdades lógicas, matemáticas y empíricas. La definición, por su parte, designa diversos procedimientos de asignación de significado, cuyas diferencias exigen una adjetivación cuidadosa: definiciones ostensivas y operacionales, definiciones de diccionario y definiciones teóricas. Pero sólo las del último tipo son verdaderas por definición. En el presente artículo se precisa el concepto formal ...

  12. $\\alpha$-curvatures and $\\alpha$-flows on low dimensional triangulated manifolds

    OpenAIRE

    Ge, Huabin; Xu, Xu

    2015-01-01

    In this paper, we introduce two discrete curvature flows, which are called $\\alpha$-flows on two and three dimensional triangulated manifolds. For triangulated surface $M$, we introduce a new normalization of combinatorial Ricci flow (first introduced by Bennett Chow and Feng Luo \\cite{CL1}), aiming at evolving $\\alpha$ order discrete Gauss curvature to a constant. When $\\alpha\\chi(M)\\leq0$, we prove that the convergence of the flow is equivalent to the existence of constant $\\alpha$-curvatur...

  13. alpha-nucleus potentials, alpha-decay half-lives, and shell closures for superheavy nuclei

    OpenAIRE

    Mohr, Peter

    2006-01-01

    Systematic alpha-nucleus folding potentials are used to analyze alpha-decay half-lives of superheavy nuclei. Preformation factors of about several per cent are found for all nuclei under study. The systematic behavior of the preformation factors and the volume integrals of the potentials allows to predict alpha-decay energies and half-lives for unknown nuclei. Shell closures can be determined from measured alpha-decay energies using the discontinuity of the volume integral at shell closures. ...

  14. Producción y tratamiento de películas de Si1-xGex mediante técnicas asistidas por láser de excímero

    Directory of Open Access Journals (Sweden)

    Castro, J.

    1998-04-01

    Full Text Available Heterostructures of Si1-xGex alloys on Si (100 have been achieved using two different excimer laser techniques. The first one, the Laser Induced Chemical Vapour Deposition (LCVD, was used in order to deposit germanium on Si (100 substrates via photolysis of GeH4 as precursor gas. The resulting films show a very homogeneous and amorphous structure as determined by HREM, XRD and Raman analysis. These deposited amorphous germanium films and a part of their underlaying Si (100 substrate were melted using the second technique, the Pulsed Laser Induced Epitaxy (PLIE, inducing an epitactic recrystallization of a Si-Ge alloy. The analysis of the obtained alloys by HREM, XRD, and XPS, reveals a strong dependence of the crystal quality and of the germanium concentration profile from the number of pulses.

    El creciente interés que suscita la búsqueda de nuevas técnicas para la obtención de materiales semiconductores, compatibles con la tecnología del silicio, ha llevado a desarrollar un sistema de depósito y postprocesado en alto vacío (HV de Si-Ge mediante técnicas asistidas por láser excímero. Se han obtenido películas amorfas de germanio mediante el depósito químico en fase vapor inducido por láser (LCVD, que posteriormente han sido recristalizadas con uso de la inducción de epitaxia por medio de láser pulsado (PLIE. Las películas depositadas sobre substratos de silicio fueron caracterizadas mediante XRD, HREM y Raman, revelándose que son amorfas con un alto grado de homogeneidad. Se ha estudiado la morfología y la estequiometría de las muestras por medio de XRD, HREM y XPS tras el tratamiento para inducir la cristalinidad de la aleación sobre el substrato de silicio, observándose la dependencia del grado de heteroepitaxia y variación de la composición en la aleación, con el número y la energía de los pulsos del láser.

  15. Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an alpha-Helical Conformation

    NARCIS (Netherlands)

    Robotta, M.; Gerding, H.R.; Vogel, A.; Hauser, K.; Schildknecht, S.; Karreman, C.; Leist, M.; Subramaniam, V.; Drescher, M.

    2014-01-01

    The human alpha-Synuclein (alphaS) protein is of significant interest because of its association with Parkinson's disease and related neurodegenerative disorders. The intrinsically disordered protein (140 amino acids) is characterized by the absence of a well-defined structure in solution. It displa

  16. Matching coefficients for alpha_s and m_b to O(alpha_s^2) in the MSSM

    CERN Document Server

    Bauer, A; Salomon, J

    2009-01-01

    We compute the exact two-loop matching coefficients for the strong coupling constant alpha_s and the bottom-quark mass m_b within the Minimal Supersymmetric Standard Model (MSSM), taking into account O(alpha_s^2) contributions from Supersymmetric Quantum Chromodynamics (SQCD). We find that the explicit mass pattern of the supersymmetric particles has a significant impact on the predictions of alpha_s and m_b at high energies. Further on, the three-loop corrections exceed the uncertainty due to the current experimental accuracy. In case of the the running bottom-quark mass, they can reach in the large tan(beta) regime up to 30% from the tree-level value.

  17. Local Varying-Alpha Theories

    CERN Document Server

    Barrow, John D

    2014-01-01

    In a recent paper we demonstrated how the simplest model for varying alpha may be interpreted as the effect of a dielectric material, generalized to be consistent with Lorentz invariance. Unlike normal dielectrics, such a medium cannot change the speed of light, and its dynamics obey a Klein-Gordon equation. This work immediately suggests an extension of the standard theory, even if we require compliance with Lorentz invariance. Instead of a wave equation, the dynamics may satisfy a local algebraic relation involving the permittivity and the properties of the electromagnetic field, in analogy with more conventional dielectric (but still preserving Lorentz invariance). We develop the formalism for such theories and investigate some phenomenological implications. The problem of the divergence of the classical self-energy can be solved, or at least softened, in this framework. Some interesting new cosmological solutions for the very early universe are found, including the possibility of a bounce, inflation and e...

  18. Intoxicación por Paraquat

    OpenAIRE

    Glenda Viales López

    2014-01-01

    El paraquat es un herbicida bipiridílico que actúa por contacto, se presenta en forma líquida en concentraciones del 20% para uso agrícola. Su nombre químico es eI 1-1´-dimetil-4-4- bipiridilo, con el nombre comercial de Gramoxone. La intoxicación por paraquat tiene una tasa de mortalidad elevada. La intoxicación grave se caracteriza por la afectación de múltiples órganos, principalmente los pulmones, los riñones y el hígado. El pulmón es el órgano diana en la intoxicación por paraquat y la i...

  19. 14 Nobel, preocupados por el CERN

    CERN Multimedia

    Rivera, A

    2003-01-01

    "E l presidente del Consejo del CERN (Laboratorio Europeo de Fisica de Particulas, junto a Ginebra), Maurice Bourquin, ha recibido una carta firmada por un grupo de cientificos muy especiales: 14 premios Nobel de Fisica" (1 page).

  20. Intoxicación por Paraquat

    Directory of Open Access Journals (Sweden)

    Glenda Viales López

    2014-12-01

    Full Text Available El paraquat es un herbicida bipiridílico que actúa por contacto, se presenta en forma líquida en concentraciones del 20% para uso agrícola. Su nombre químico es eI 1-1´-dimetil-4-4- bipiridilo, con el nombre comercial de Gramoxone. La intoxicación por paraquat tiene una tasa de mortalidad elevada. La intoxicación grave se caracteriza por la afectación de múltiples órganos, principalmente los pulmones, los riñones y el hígado. El pulmón es el órgano diana en la intoxicación por paraquat y la insuficiencia respiratoria con fibrosis pulmonar aguda es la causa más común de muerte.

  1. Micetoma por Nocardia brasiliensis: reporte de caso

    Directory of Open Access Journals (Sweden)

    Miriam Guevara R

    2003-07-01

    Full Text Available Se presenta el caso de un paciente peruano, agricultor, con una infección cutánea de origen traumático causada por Nocardia brasiliensis, que evolucionó hacia la amputación del miembro inferior afectado. El diagnóstico se realizó por examen directo y cultivo del espécimen.

  2. Confidence Intervals for Cronbach's Coefficient Alpha Values

    NARCIS (Netherlands)

    A.J. Koning (Alex); Ph.H.B.F. Franses (Philip Hans)

    2003-01-01

    textabstractCoefficient Alpha, which is widely used in empirical research, estimates the reliability of a test consisting of parallel items. In practice it is difficult to compare values of alpha across studies as it depends on the number of items used. In this paper we provide a simple solution, wh

  3. ALPHA experiment facility and Prof. Jeffrey Hangst.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    Picture 01-07: General views of the ALPHA experiment Picture 5: Andrea Gutierrez, a PhD student from UBC, transfers liquid helium from a storage dewar into the cryostat containing the superconducting magnetic trap used by the ALPHA experiment.Picture 08-11: Jeffery Hangst, spokesperson for ALPHA Picture 12: The ALPHA silicon detector, which surrounds the trapping resion and is used for imaging antiproton annihilations (Credit University of Liverpool) Picture 13: Untrapped antihydrogen atoms annihilating on the inner surface of the ALPHA trap. These are measured by the ALPHA annihilation detector. The events are concentrated at the electrode radius of about 22.3 mm. The coordinates are defined in the Nature article, Figure 1b. Picture 14: The electrodes (gold) for the ALPHA Penning trap being inserted into the vacuum chamber and cryostat assembly. This is the trap used to combine or "mix" positrons and antiprotons to make antihydrogen. (Credit: Niels Madsen ALPHA/Swansea.) Picture 15: Top, a diagram of the...

  4. Single-field $\\alpha$-attractors

    CERN Document Server

    Linde, Andrei

    2015-01-01

    I describe a simple class of $\\alpha$-attractors, generalizing the single-field GL model of inflation in supergravity. The new class of models is defined for $0<\\alpha \\lesssim 1$, providing a good match to the present cosmological data. I also present a generalized version of these models which can describe not only inflation but also dark energy and supersymmetry breaking.

  5. Coefficient Alpha Bootstrap Confidence Interval under Nonnormality

    Science.gov (United States)

    Padilla, Miguel A.; Divers, Jasmin; Newton, Matthew

    2012-01-01

    Three different bootstrap methods for estimating confidence intervals (CIs) for coefficient alpha were investigated. In addition, the bootstrap methods were compared with the most promising coefficient alpha CI estimation methods reported in the literature. The CI methods were assessed through a Monte Carlo simulation utilizing conditions…

  6. Miglitol, a new alpha-glucosidase inhibitor

    NARCIS (Netherlands)

    Sels, J P; Huijberts, M S; Wolffenbuttel, B H

    1999-01-01

    Miglitol (Bay m 1099, Bayer) is a second generation alpha-glucosidase inhibitor. It is a derivative of 1-desoxynojirimycin, and binds reversibly to the brushborder alpha-glucosidase enzymes. In contrast to its parent drug (acarbose, Bay g 5421, Bayer), miglitol is almost completely absorbed in the s

  7. Teaching Calculus with Wolfram|Alpha

    Science.gov (United States)

    Dimiceli, Vincent E.; Lang, Andrew S. I. D.; Locke, LeighAnne

    2010-01-01

    This article describes the benefits and drawbacks of using Wolfram|Alpha as the platform for teaching calculus concepts in the lab setting. It is a result of our experiences designing and creating an entirely new set of labs using Wolfram|Alpha. We present the reasoning behind our transition from using a standard computer algebra system (CAS) to…

  8. Anomalous atomic volume of alpha-Pu

    DEFF Research Database (Denmark)

    Kollar, J.; Vitos, Levente; Skriver, Hans Lomholt

    1997-01-01

    .3%. The comparison between the LDA and GGA results show that the anomalously large atomic volume of alpha-Pu relative to alpha-Np can be ascribed to exchange-correlation effects connected with the presence of low coordinated sites in the structure where the f electrons are close to the onset of localization...

  9. An Alpha Schottky Junction Power Source

    Science.gov (United States)

    Litz, Marc; Carroll, James; Henriquez, Stan

    2011-10-01

    Isotope batteries present solutions for long-lived low power sources. Compact sensors, and electronic circuit boards can be powered for the lifetime of infrastructure. Alpha sources are practical for safety reasons because of the limited distance before energy absorption in materials, and the high energy (~5MeV) per particle. Damage to materials from the alphas limits the practical use. A Schottky diode geometry is created from an alpha foil on a diamond-like crystal. A power source is proposed that takes advantage of the radiation damage tolerance of diamond, combined with the short range of the alpha radiation. The internal field of the Schottky barrier creates a current through the diode from electron-hole pairs created by alpha bombardment in the gap. Calculations of the expected current, circuit model results, and design parameters for a device are described.

  10. Determination of alpha_s from the QCD static energy: an update

    CERN Document Server

    Bazavov, Alexei; Tormo, Xavier Garcia i; Petreczky, Peter; Soto, Joan; Vairo, Antonio

    2014-01-01

    We present an update of our determination of the strong coupling alpha_s from the quantum chromodynamics static energy. This updated analysis includes new lattice data, at smaller lattice spacings and reaching shorter distances, the use of better suited perturbative expressions to compare with data in a wider distance range, and a comprehensive and detailed estimate of the error sources that contribute to the uncertainty of the final result. Our updated value for alpha_s at the Z-mass scale, M_Z, is alpha_s(M_Z)=0.1166^{+0.0012}_{-0.0008}, which supersedes our previous result.

  11. A low-energy determination of $\\alpha_s$ at three loops

    CERN Document Server

    Vairo, Antonio

    2015-01-01

    We review one of the most accurate low-energy determinations of $\\alpha_s$. Comparing at short distances the QCD static energy at three loops and resummation of the next-to-next-to leading logarithms with its determination in 2+1-flavor lattice QCD, we obtain $\\alpha_s(1.5~{\\rm GeV})=0.336^{+0.012}_{-0.008}$, which corresponds to $\\alpha_s(M_Z)=0.1166^{+0.0012}_{-0.0008}$. We discuss future perspectives.

  12. Catalytic Mechanism of Human Alpha-galactosidase

    Energy Technology Data Exchange (ETDEWEB)

    Guce, A.; Clark, N; Salgado, E; Ivanen, D; Kulinskaya, A; Brumer, H; Garman, S

    2010-01-01

    The enzyme {alpha}-galactosidase ({alpha}-GAL, also known as {alpha}-GAL A; E.C. 3.2.1.22) is responsible for the breakdown of {alpha}-galactosides in the lysosome. Defects in human {alpha}-GAL lead to the development of Fabry disease, a lysosomal storage disorder characterized by the buildup of {alpha}-galactosylated substrates in the tissues. {alpha}-GAL is an active target of clinical research: there are currently two treatment options for Fabry disease, recombinant enzyme replacement therapy (approved in the United States in 2003) and pharmacological chaperone therapy (currently in clinical trials). Previously, we have reported the structure of human {alpha}-GAL, which revealed the overall structure of the enzyme and established the locations of hundreds of mutations that lead to the development of Fabry disease. Here, we describe the catalytic mechanism of the enzyme derived from x-ray crystal structures of each of the four stages of the double displacement reaction mechanism. Use of a difluoro-{alpha}-galactopyranoside allowed trapping of a covalent intermediate. The ensemble of structures reveals distortion of the ligand into a {sup 1}S{sub 3} skew (or twist) boat conformation in the middle of the reaction cycle. The high resolution structures of each step in the catalytic cycle will allow for improved drug design efforts on {alpha}-GAL and other glycoside hydrolase family 27 enzymes by developing ligands that specifically target different states of the catalytic cycle. Additionally, the structures revealed a second ligand-binding site suitable for targeting by novel pharmacological chaperones.

  13. Direct Alpha Analysis for Forensic Samples (DAAFS)

    International Nuclear Information System (INIS)

    The goal of the DAAFS project is to deliver a field deployable direct alpha sample spectrometry system. This system is designed to rectify current gaps in pure alpha emitting material detection. The system comprises, firstly, an evaluation of multiple innovative methods for rapid on-site sample collection of difficult to detect alpha RN contamination. Secondly, the incorporation of an experimental alpha spectrometry analysis software suite, 'ADAM', is provided for performing the required on-site deconvolution of the complex alpha spectra arising from the direct sample measurement. Software simulation of collected alpha spectra will be handled by 'AASI', which will simulate alpha spectra as a training and analysis verification tool. Thirdly, a Concept of Operations (ConOps) for the system implementation in RN field teams is included. This combination of the swipe methodology, advanced swipe treatment equipment, mobile field laboratories, and the state of the art analysis software suite will provide RN response teams with the capability to identify and rapidly (i.e., hours as opposed to days) quantify low activity and difficult to detect alpha emitters. Further expert analysis support is available to field teams by sharing of raw spectral data via email with off-site laboratories. The proposed system provides the solution to this identified capability gap, specifically, a field-deployable real-time alpha detection system. The system comprises: a non-destructive particle sampler, standardized swipe sampling methods, a self-contained field alpha spectrometry system and an integrated data management/communications tool allowing for real-time raw-data tracking and data sharing. This system also provides responders with the type/quantity of RN material for improved safeguards, forensics, and contamination mitigation applications. (author)

  14. Folate receptor {alpha} regulates cell proliferation in mouse gonadotroph {alpha}T3-1 cells

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Congjun; Evans, Chheng-Orn [Department of Neurosurgery and Laboratory of Molecular Neurosurgery and Biotechnology, Emory University, School of Medicine, Atlanta, Georgia (United States); Stevens, Victoria L. [Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia (United States); Owens, Timothy R. [Emory University, School of Medicine, Atlanta, Georgia (United States); Oyesiku, Nelson M., E-mail: noyesik@emory.edu [Department of Neurosurgery and Laboratory of Molecular Neurosurgery and Biotechnology, Emory University, School of Medicine, Atlanta, Georgia (United States)

    2009-11-01

    We have previously found that the mRNA and protein levels of the folate receptor alpha (FR{alpha}) are uniquely over-expressed in clinically human nonfunctional (NF) pituitary adenomas, but the mechanistic role of FR{alpha} has not fully been determined. We investigated the effect of FR{alpha} over-expression in the mouse gonadotroph {alpha}T3-1 cell line as a model for NF pituitary adenomas. We found that the expression and function of FR{alpha} were strongly up-regulated, by Western blotting and folic acid binding assay. Furthermore, we found a higher cell growth rate, an enhanced percentage of cells in S-phase by BrdU assay, and a higher PCNA staining. These observations indicate that over-expression of FR{alpha} promotes cell proliferation. These effects were abrogated in the same {alpha}T3-1 cells when transfected with a mutant FR{alpha} cDNA that confers a dominant-negative phenotype by inhibiting folic acid binding. Finally, by real-time quantitative PCR, we found that mRNA expression of NOTCH3 was up-regulated in FR{alpha} over-expressing cells. In summary, our data suggests that FR{alpha} regulates pituitary tumor cell proliferation and mechanistically may involve the NOTCH pathway. Potentially, this finding could be exploited to develop new, innovative molecular targeted treatment for human NF pituitary adenomas.

  15. [Contents and its change during storage of alpha-solanine and alpha-chaconine in potatoes].

    Science.gov (United States)

    Shindo, Tetsuya; Ushiyama, Hirofumi; Kan, Kimiko; Yasuda, Kazuo; Saito, Kazuo

    2004-10-01

    Contents of alpha-solanine and alpha-chaconine in native species of potato (May Queen, Danshaku and Waseshiro), and in species (Jagakids Red '90 (Red) and Jagakids Purple '90 (Purple)) on the market, and their change during storage at room temparature were investigated. alpha-Solanine and alpha-chaconine were extracted from potatoes with methanol, cleaned up by using a Sep-Pak Plus C18 cartridge, and then subjected to HPLC. The recoveries of alpha-solanine and alpha-chaconine from potatoes were both more than 96%, and the quantitation limits were both 2 microg/g. alpha-Solanine and alpha-chaconine were detected in periderm in all samples at the levels of 260-320 microg/g in May Queen,190-240 microg/g in Danshaku, 43-63 microg/g in Waseshiro, 140-200 microg/g in Red and 84-130 microg/g in Purple, respectively. alpha-Solanine and alpha-chaconine were detected in the cortex in all samples of May Queen and Danshaku at the levels of 2.7-12 microg/g and 5.8-31 microg/g, respectively. Contents of alpha-solanine and alpha-chaconine in the cortex of May Queen and Danshaku were less than 10% of those in the periderm. When potatoes were stored for 90 days at room temparature in a dark place, no marked change in the contents of alpha-solanine and alpha-chaconine was observed in any of the potato samples.

  16. Efecto de la infección de células dendríticas humanas por promastigotes de Leishmania(Viannia panamensis

    Directory of Open Access Journals (Sweden)

    Sara María Robledo Restrepo

    2004-02-01

    Full Text Available Introducción: las células dendríticas (CD pueden iniciar respuestas antimicrobianas por su gran capacidad como células presentadoras de antígeno; sin embargo, parásitos intracelulares como Leishmania han desarrollado estrategias para evitar el reconocimiento de la célula infectada. Por lo tanto, es importante evaluar la interacción entre parásito y CD al igual que los efectos de la infección en puntos cruciales para la respuesta inmune como lo es la regulación de moléculas involucradas en la presentación antigénica y la activación de linfocitos específicos del parásito. Objetivo: determinar los cambios fenotípicos y funcionales inducidos por la infección con promastigotes de L. (V panamensis en CD derivadas de monocitos humanos. Metodología: CD derivadas de monocitos de sangre periférica de individuos con leishmaniosis activa y controles sanos se estimularon in vitro con parásitos durante 24 horas. La expresión de moléculas CD1a, HLA, CD80 y CD86 se evaluó por citometría de flujo al igual que la regulación de poblaciones de linfocitos T CD4+ y CD8+ en cocultivo con CD. Resultados preliminares: La infección regula negativamente la expresión de CD1a y positivamente la expresión de moléculas HLA-I y II. Las moléculas coestimuladoras son diferencialmente reguladas durante la infección de CD. El cocultivo de linfocitos con CD infectadas con L. (V panamensis aumenta el porcentaje de linfocitos T CD4+ y CD8+ en un 100% y 50% respectivamente con respecto a los cocultivos de los linfocitos con CD sin infectar. Conclusiones : La disminución en la expresión de CD1a y CD80 y el evidente aumento en la expresión de las moléculas HLA sugieren que durante la presentación de antígenos lipídicos a través de CD1a, y proteicos a través de HLA, existen mecanismos diferenciales de regulación e interacción entre el parásito y la célula dendrítica y el balance resultante de esta interacción es el que probablemente define

  17. Lucid dreaming and alpha activity: a preliminary report.

    Science.gov (United States)

    Ogilvie, R D; Hunt, H T; Tyson, P D; Lucescu, M L; Jeakins, D B

    1982-12-01

    10 good dream recallers spent 2 nights in the sleep lab during which they were awakened 4 times per night from REM sleep, twice during their highest alpha activity in REM, and twice during low REM alpha. 5 were given alpha feedback training prior to sleep onset. Arousals from high alpha REM sleep yielded significantly higher lucidity ratings. Alpha feedback had no effect upon lucidity or REM alpha levels. Similarities between lucid dreams and meditative phenomena are discussed.

  18. Osmotic fragility test in heterozygotes for alpha and beta thalassaemia.

    OpenAIRE

    Maccioni, L; Cao, A

    1985-01-01

    This study shows that the combination of heterozygous beta thalassaemia and deletion heterozygous (-alpha/alpha alpha) or homozygous (-alpha/-alpha) alpha+ thalassaemia may result in the production of erythrocytes which have normal mean volume and haemoglobinisation but decreased osmotic fragility. Based on this finding and previous studies, which have shown that beta thalassaemia screening by the osmotic fragility test may miss a significant proportion of beta thalassaemia heterozygotes, we ...

  19. Lucid dreaming and alpha activity: a preliminary report.

    Science.gov (United States)

    Ogilvie, R D; Hunt, H T; Tyson, P D; Lucescu, M L; Jeakins, D B

    1982-12-01

    10 good dream recallers spent 2 nights in the sleep lab during which they were awakened 4 times per night from REM sleep, twice during their highest alpha activity in REM, and twice during low REM alpha. 5 were given alpha feedback training prior to sleep onset. Arousals from high alpha REM sleep yielded significantly higher lucidity ratings. Alpha feedback had no effect upon lucidity or REM alpha levels. Similarities between lucid dreams and meditative phenomena are discussed. PMID:7162915

  20. Lyman Alpha Emitter Evolution Through Reionization

    CERN Document Server

    Dayal, P; Saro, A; Salvaterra, R; Borgani, S; Tornatore, L

    2009-01-01

    Combining cosmological SPH simulations with a previously developed Lyman Alpha production/transmission model and the Early Reionization Model (ERM, reionization ends at redshift z~7), we obtain Lyman Alpha and UV Luminosity Functions (LFs) for Lyman Alpha Emitters (LAEs) for redshifts between 5.7 and 7.6. Matching model results to observations at z~5.7 requires escape fractions of Lyman Alpha, f_alpha=0.3, and UV (non-ionizing) continuum photons, f_c=0.22, corresponding to a color excess, E(B-V)=0.15. We find that (i) f_c increases towards higher redshifts, due the decreasing mean dust content of galaxies, (ii) the evolution of f_alpha/f_c hints at the dust content of the ISM becoming progressively inhomogeneous/clumped with decreasing redshift. The clustering photoionization boost is important during the initial reionization phases but has little effect on the Lyman Alpha LF for a highly ionized IGM. With no more free parameters, the Spectral Energy Distributions of three LAE at z~5.7 observed by Lai et al. ...

  1. Angiografia por tomografia computadorizada dos aneurismas intracranianos

    Directory of Open Access Journals (Sweden)

    Laureano Vinícius Santos

    2002-01-01

    Full Text Available Este trabalho foi realizado para avaliar os achados da angiografia por tomografia computadorizada, comparativamente à angiografia por subtração digital, em relação aos aneurismas intracranianos, e a possibilidade da maior utilização da angiografia por tomografia computadorizada no Brasil. Foram analisados oito pacientes que apresentavam um total de sete aneurismas não tratados e um aneurisma tratado. Houve subseqüente correlação com outros trabalhos publicados na literatura médica. Os exames foram realizados em uma clínica e em dois hospitais privados, na cidade do Rio de Janeiro, RJ. Foi demonstrada boa correlação entre os métodos estudados, em relação ao diagnóstico dos aneurismas, no acompanhamento e avaliação pré-terapêutica dessas lesões. A angiografia por tomografia computadorizada foi um exame menos invasivo, de menor custo e maior acessibilidade. Concluiu-se que a angiografia por tomografia computadorizada é um exame que deve ser utilizado com maior freqüência para avaliação nesta enfermidade.

  2. Biochemical characterization of CK2alpha and alpha' paralogues and their derived holoenzymes: evidence for the existence of a heterotrimeric CK2alpha'-holoenzyme forming trimeric complexes

    DEFF Research Database (Denmark)

    Olsen, Birgitte; Rasmussen, Tine; Niefind, Karsten;

    2008-01-01

    Altogether 2 holoenzymes and 4 catalytic CK2 constructs were expressed and characterized i.e. CK2alpha (2) (1-335) beta(2); CK2alpha'-derived holoenzyme; CK2alpha(1-335); MBP-CK2alpha'; His-tagged CK2alpha and His-tagged CK2alpha'. The two His-tagged catalytic subunits were expressed in insect......2alpha'-derived holoenzyme eluted at a position corresponding to a molecular mass of 105 kDa which is significantly below the elution of the CK2alpha (2) (1-335) beta(2) holoenzyme (145 kDa). Calmodulin was not phosphorylated by either CK2alpha (2) (1-335) beta(2) or the CK2alpha'-derived holoenzyme...

  3. Diagnostics for PLX-alpha

    Science.gov (United States)

    Gilmore, Mark; Hsu, Scott

    2015-11-01

    The goal of the Plasma Liner eXperiment PLX-alpha at Los Alamos National Laboratory is to establish the viability of creating a spherically imploding plasma liner for MIF and HED applications, using a spherical array of supersonic plasma jets launched by innovative contoured-gap coaxial plasma guns. PLX- α experiments will focus in particular on establishing the ram pressure and uniformity scalings of partial and fully spherical plasma liners. In order to characterize these parameters experimentally, a suite of diagnostics is planned, including multi-camera fast imaging, a 16-channel visible interferometer (upgraded from 8 channels) with reconfigurable, fiber-coupled front end, and visible and VUV high-resolution and survey spectroscopy. Tomographic reconstruction and data fusion techniques will be used in conjunction with interferometry, imaging, and synthetic diagnostics from modeling to characterize liner uniformity in 3D. Diagnostic and data analysis design, implementation, and status will be presented. Supported by the Advanced Research Projects Agency - Energy - U.S. Department of Energy.

  4. Remote Optical Detection of Alpha Radiation

    International Nuclear Information System (INIS)

    Alpha emitting radiation sources are typically hard to detect with conventional detectors due to the short range of alpha particles in the air. However, previous studies have shown that remote detection of alpha radiation is possible by measuring the ionization-induced fluorescence of air molecules. The alpha-induced ultraviolet (UV) light is mainly emitted by molecular nitrogen and its fluorescence properties are well known. The benefit of this method is the long range of UV photons in the air. Secondly, the detection is possible also under a strong beta and gamma radiation backgrounds as they do not cause localized molecular excitation. In this work, the optical detection was studied using two different detection schemes; spectral separation of fluorescence from the background lighting and coincidence detection of UV photons originating from a single radiative decay event. Our spectrally integrated measurements have shown that one alpha decay event yields up to 400 fluorescence photons in the air and all these UV photons are induced in a 5 ns time-window. On the other hand, the probability of a background coincidence event in 5 ns scale is very rare compared to the number of background photons. This information can be applied in fluorescence coincidence filtering to discriminate the alpha radiation initiated fluorescence signal from much more intense background lighting. A device called HAUVA (Handheld Alpha UV Application) was built during this work for demonstration purposes. HAUVA utilizes spectral filtering and it is designed to detect alpha emitters from a distance of about 40 cm. Using specially selected room lighting, the device is able to separate 1 kBq alpha emitter from the background lighting with 1 second integration time. (author)

  5. Growth behaviors in the range $e^{r^\\alpha}$

    OpenAIRE

    Brieussel, Jérémie

    2011-01-01

    For every $\\alpha \\leq \\beta$ in a left neighborhood $[\\alpha_0,1]$ of 1, a group $G(\\alpha,\\beta)$ is constructed, the growth function of which satisfies $\\limsup \\frac{\\log \\log b_{G(\\alpha,\\beta)}(r)}{\\log r}=\\alpha$ and $\\liminf \\frac{\\log \\log b_{G(\\alpha,\\beta)}(r)}{\\log r}=\\beta$. When $\\alpha=\\beta$, this provides an explicit uncountable collection of groups with growth functions strictly comparable. On the other hand, oscillation in the case $\\alpha < \\beta$ explains the existence of...

  6. Measurements of $\\alpha_s$ in $pp$ Collisions at the LHC

    CERN Document Server

    Warburton, Andreas; The ATLAS collaboration

    2015-01-01

    The coupling of the strong force, $\\alpha_s$, is deemed to be a fundamental parameter of Nature, and, beyond the quark masses, constitutes the only free parameter in the QCD Lagrangian. Provided is an overview of CERN Large Hadron Collider (LHC) measurements of $\\alpha_s(M_Z)$ evaluated at the $Z$-boson mass and of the running of $\\alpha_s(Q)$ as a function of energy-momentum transfer $Q$. The measurements were performed by the ATLAS and CMS Collaborations using proton-proton ($pp$) collisions with centre-of-mass energies of 7 TeV and data samples with time-integrated luminosities of up to 5 fb$^{-1}$. Four different categories of observable were used in the described extractions of $\\alpha_s$: inclusive jet cross sections, 3-jet to 2-jet inclusive cross-section ratios, 3-jet mass cross sections, and top-quark pair production cross sections. These results, which include the first NNLO measurement of $\\alpha_s$ at a hadron collider and the first determinations of $\\alpha_s$ at energy scales above 1 TeV, are co...

  7. $\\alpha_s$ from the updated ALEPH data for hadronic $\\tau$ decays

    CERN Document Server

    Boito, Diogo; Maltman, Kim; Osborne, James; Peris, Santiago

    2015-01-01

    We extract the strong coupling $\\alpha_s(m_\\tau^2)$ from the recently updated ALEPH non-strange spectral functions obtained from hadronic $\\tau$ decays. We apply a self-consistent analysis method, first tested in the analysis of OPAL data, to extract $\\alpha_s(m_\\tau^2)$ and non-perturbative contributions. The analysis yields $\\alpha_s^{\\rm FO}(m_\\tau^2)=0.296\\pm0.010 $, using Fixed Order Perturbation Theory (FOPT), and $\\alpha^{\\rm CI}_s(m_\\tau^2)= 0.310\\pm0.014$, using Contour Improved Perturbation Theory (CIPT). The weighted average of these results with those previously obtained from OPAL data give $\\alpha_s^{\\rm FO}(m_\\tau^2)=0.303\\pm 0.009$ and $\\alpha_s^{\\rm CI}(m_\\tau^2)=0.319\\pm 0.012$, which gives, after evolution to the $Z$ boson mass scale, $\\alpha^{\\rm FO}_s(m_Z^2)=0.1165\\pm0.0012 $ and $\\alpha_s^{\\rm CI}(m_Z^2)=0.1185\\pm0.0015 $, respectively. We observe that non-perturbative effects limit the accuracy with which $\\alpha_s$ can be extracted from $\\tau$ decay data.

  8. Lyman alpha airglow observations from SORCE SOLSTICE

    Science.gov (United States)

    Dolinar, E.; Snow, M.; Holsclaw, G.; Thomas, G. E.; Woods, T. N.

    2010-12-01

    The Solar Stellar Irradiance Comparison Experiment (SOLSTICE) instrument on board the Solar Radiation Climate Experiment (SORCE) spacecraft in low Earth orbit observes stars every orbit for in-flight calibration. It also observes several star-free regions of the sky near the wavelength of Lyman alpha to correct for airglow emission in the stellar measurements. Although the airglow measurements are only taken during the eclipse portion of the orbit, the look directions cover nearly the entire anti-sunward hemisphere. This seven-year record of Lyman alpha airglow observations (2003-2010) shows the response of the Hydrogen geocorona to changes in the solar Lyman alpha irradiance over the solar cycle.

  9. Alpha particle confinement in tandem mirrors

    International Nuclear Information System (INIS)

    Mechanisms leading to loss of alpha particles from non-axisymmetric tandem mirrors are considered. Stochastic diffusion due to bounce-drift resonances, which can cause rapid radial losses of high-energy alpha particles, can be suppressed by imposing a 20% rise in axisymmetric fields before the quadrupole transition sections. Alpha particles should then be well-confined until thermal energies when they enter the resonant plateau require. A fast code for computation of drift behavior in reactors is described. Sample calculations are presented for resonant particles in a proposed coil set for the Tandem Mirror Next Step

  10. Determining cellular role of G alpha 12.

    Science.gov (United States)

    Dermott, Jonathan M; Dhanasekaran, N

    2002-01-01

    Using the expression strategies described here, we have demonstrated a model system whereby the sequential signaling events involved in cell proliferation and subsequent transformation regulated by G alpha 12 can be investigated. The model system presented here can also be used to study the temporal interrelationships between small GTPases, kinases, and other signaling proteins involved in G alpha 12-signaling pathways. Further analyses using this model system and the strategies presented here should provide valuable clues in defining the signaling network regulated by G alpha 12 in stimulating cell proliferation and oncogenic transformation. PMID:11771390

  11. First Attempts at Antihydrogen Trapping in ALPHA

    CERN Document Server

    Andresen, G B; Bowe, P D; Bray, C C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Funakoshi, R; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A J; Hydomako, R; Jenkins, M J; Jørgensen, L V; Kurchaninov, L; Lambo, R; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Page, R D; Povilus, A; Pusa, P; Robicheaux, F; Sarid, E; Seif El Nasr, S; Silveira, D M; Storey, J W; Thompson, R I; Van der Werf, D P; Wasilenko, L; Wurtele, J S; Yamazaki, Y; Fujiwara, M C

    2008-01-01

    We discuss aspects of antihydrogen studies, that relate to particle physics ideas and techniques, within the context of the ALPHA experiment at CERN's Antiproton Decelerator facility. We review the fundamental physics motivations for antihydrogen studies, and their potential physics reach. We argue that initial spectroscopy measurements, once antihydrogen is trapped, could provide competitive tests of CPT, possibly probing physics at the Planck Scale. We discuss some of the particle detection techniques used in ALPHA. Preliminary results from commissioning studies of a partial system of the ALPHA Si vertex detector are presented, the results of which highlight the power of annihilation vertex detection capability in antihydrogen studies.

  12. La conquista de Niebla por Alfonso X

    OpenAIRE

    García Sanjuán, Alejandro

    2000-01-01

    La conquista de Niebla en 660 H/1262 d.n.e. por el rey Alfonso X (1252-1284) puso fin a los cinco siglos y medio de Historia andalusí de dicha ciudad, largo período iniciado desde su sumisión por `Abd al- c Aziz b. Milsá en 94/713, al comienzo de la irrupción islámica en la Península Ibérica. Se trata, por lo tanto, de un episodio de gran relevancia en el devenir histórico de esta localidad, que ya desde época visigoda fue el principal núcleo urbano del territorio onubens...

  13. Determination of alpha_s and W boson leptonic branching ratio from the W and Z cross sections

    CERN Document Server

    Xiao, Weichen

    2016-01-01

    We try to determine the strong coupling alpha_s and the W boson leptonic branching ratio from the W and Z boson production cross section through pp collisions in the LHC. We run the MCFM program together with LHAPDF or HERAPDF les to extract the theoretical prediction of cross sections at different alpha_s in different experiments. We compare the predicted values and the experimental results to do a precise measurement of alpha_s and the branching ratio.

  14. Lambda alpha, Sigma alpha and Xi alpha potentials derived from the SU6 quark-model baryon-baryon interaction

    CERN Document Server

    Fujiwara, Y; Suzuki, Y

    2006-01-01

    We calculate Lambda alpha, Sigma alpha and Xi alpha potentials from the nuclear-matter G-matrices of the SU6 quark-model baryon-baryon interaction. The alpha-cluster wave function is assumed to be a simple harmonic-oscillator shell-model wave function. A new method is proposed to derive the direct and knock-on terms of the interaction Born kernel from the hyperon-nucleon G-matrices, with explicit treatments of the nonlocality and the center-of-mass motion between the hyperon and alpha. We find that the SU6 quark-model baryon-baryon interactions, FSS and fss2, yield a reasonable bound-state energy for 5 He Lambda, -3.18 -- -3.62 MeV, in spite of the fact that they give relatively large depths for the Lambda single-particle potentials, 46 -- 48 MeV, in symmetric nuclear matter. An equivalent local potential derived from the Wigner transform of the nonlocal Lambda alpha kernel shows a strong energy dependence for the incident Lambda-particle, indicating the importance of the strangeness-exchange process in the o...

  15. Neumopericardio debido a herida por arma blanca

    Directory of Open Access Journals (Sweden)

    Samuel I. Merino Barrera

    2015-10-01

    Full Text Available Hombre de 24 años de edad que ingresó en el hospital debido a una herida por arma blanca penetrante en el hemitórax derecho. La herida, de 3 cm a nivel de la piel, se localizaba a nivel del segundo espacio intercostal derecho y la radiografía de tórax demostró un neumotórax del mismo lado y una colección radiotransparente, por debajo del pericardio parietal, desde el origen de los grandes vasos hasta la porción apical del ventrículo izquierdo.

  16. Neumopericardio debido a herida por arma blanca

    OpenAIRE

    Samuel I. Merino Barrera; Francisco L. Moreno-Martínez

    2015-01-01

    Hombre de 24 años de edad que ingresó en el hospital debido a una herida por arma blanca penetrante en el hemitórax derecho. La herida, de 3 cm a nivel de la piel, se localizaba a nivel del segundo espacio intercostal derecho y la radiografía de tórax demostró un neumotórax del mismo lado y una colección radiotransparente, por debajo del pericardio parietal, desde el origen de los grandes vasos hasta la porción apical del ventrículo izquierdo.

  17. Endoftalmite por Candida albicans Candida albicans endophthalmitis

    Directory of Open Access Journals (Sweden)

    Pedro Duraes Serracarbassa

    2003-10-01

    Full Text Available O autor descreve os aspectos epidemiológicos, histopatológicos e clínicos da endoftalmite endógena por Candida albicans. Apresenta ainda novos métodos diagnósticos e opções terapêuticas utilizadas no tratamento das infecções fúngicas intra-oculares, por meio de revisão bibliográfica.The author describes epidemiological, histopathological and clinical aspects of endogenous Candida albicans endophthalmitis. He also presents new diagnostic methods and therapeutical options to treat intraocular fungal infections, based on literature review.

  18. PANORAMA LATINOAMERICANO DEL PAGO POR SERVICIOS AMBIENTALES

    Directory of Open Access Journals (Sweden)

    González T. Ángela

    2008-07-01

    Full Text Available Este documento busca proveer al lector de algunos elementos para el análisis y reflexión en torno al pago por servicios ambientales. Para ello, en primera instancia, aborda algunos conceptos básicos relacionados con economía ambiental, seguido de temas como la valoración económica de servicios ambientales y la implementación de mecanismos de pago por algunos de ellos. Lo anterior esta enriquecido con experiencias o estudios de caso a nivel latinoamericano y colombiano.

  19. Choque séptico por ehrliquiosis

    OpenAIRE

    Viviana Hernández-de Mezerville; Juan I Padilla-Cuadra

    2007-01-01

    La ehrliquiosis humana es una infección zoonótica transmitida por "garrapatas duras" causada por Anaplasma sp y Ehrlichia sp. Puede presentarse como un cuadro pseudogripal con fiebre, malestar general, mialgias y cefalea o hasta un choque séptico con falla multiorgánica y muerte. La mitad de los pacientes requieren atención hospitalaria en algún momento y se reporta una mortalidad de hasta el 5% secundaria a enfermedades oportunistas o a hemorragias. El diagnóstico se puede sospechar visualiz...

  20. Neutron-induced alpha radiography

    International Nuclear Information System (INIS)

    A new radiography technique to inspect thin samples was developed. Low energy alpha particles, generated by a boron based screen under thermal neutron irradiation, are used as penetrating radiation. The solid state nuclear track detector CR-39 has been used to register the image. The interaction of the α - particles with the CR-39 gives rise to damages which under an adequate chemical etching became tracks the basic units forming the image. A digital system was developed for data acquisition and data analysis as well as for image processing. The irradiation and etching conditions to obtain the best radiography are 1,3 hours and 25 minutes at 70 deg C respectively. For such conditions samples having 10 μm in thickness can be inspected with a spatial resolution of 32 μm. The use of the digital system has reduced the time spent for data acquisition and data analysis and has improved the radiography image visualization. Furthermore, by using the digital system, it was possible to study several new parameters regarding the tracks which are very important to understand and study the image formation theory in solid state nuclear track detectors, the one used in this thesis. Some radiography images are also shown which demonstrate the potential of the proposed radiography technique. When compared with the other radiography techniques already in use to inspect thin samples, the present one developed in the present paper allows a smaller time to obtain the image, it is not necessary to handle liquid radioactive substances, the detector is insensitive to β, γ, X-ray and visible light. (author)

  1. Lattice measurement of \\alpha_s with a realistic charm quark

    CERN Document Server

    Blossier, B; Brinet, M; De Soto, F; Du, X; Morenas, V; Pene, O; Petrov, K; Rodriguez-Quintero, J

    2012-01-01

    We report on an estimate of \\alpha_s, renormalised in the MSbar scheme at the tau and Z^0 mass scales, by means of lattice QCD. Our major improvement compared to previous lattice calculations is that, for the first time, no perturbative treatment at the charm threshold has been required since we have used statistical samples of gluon fields built by incorporating the vacuum polarisation effects of u/d, s and c sea quarks. Extracting \\alpha_s in the Taylor scheme from the lattice measurement of the ghost-ghost-gluon vertex, we obtain \\alpha_s^{MSbar}(m^2_Z)=0.1200(14) and \\alpha_s^{MSbar}(m^2_tau)=0.339(13).

  2. Improved parametrization of the unified model for alpha decay and alpha capture

    CERN Document Server

    Denisov, V Yu; Sedykh, I Yu

    2015-01-01

    The updated data for the ground-state-to-ground-state alpha-transition half-lives in 401 nuclei and the alpha capture cross sections of 40Ca, 44Ca, 59Co, 208Pb and 209Bi are well described in the framework of the unified model for alpha-decay and alpha-capture. The updated values of the alpha decay half-lives, the binding energies of nuclei, the spins of parent and daughter nuclei, and the surface deformation parameters are used for the reevaluation of the model parameters. The data for the ground-state-to-ground-state alpha-decay half-lives are also well described by the empirical relationships.

  3. An alpha-omega-dynamo with an alpha-effect due to magnetostrophic waves

    Science.gov (United States)

    Schmitt, D.

    1987-03-01

    The effects of the latitude dependence of the dynamic alpha-effect on the solution of equations of alpha-omega-dynamos are investigated. The equations of kinematic rotationally symmetric alpha-omega-dynamos are evaluated using the spherical solar dynamo model of Deinzer and Stix (1971), in which the induction effects, differential rotation, and alpha-effect act in two separate infinitesimal thin shells. Butterfly diagrams are derived and analyzed. It is observed that the diagram has two branches: the ordinary sunspot branch, migrating from midlatitudes toward the equator during the cycle, and the polar branch, which migrates from the midlatitudes toward the pole. It is also found that, in order to obtain the correct propagation direction of the two dynamos, the alpha of the magnetostrophic waves requires a rotation decreasing with depth. The influence of various locations of the induction layers of alpha- and omega-effect are examined.

  4. Energy dependence of event shapes and of $\\alpha_s$ at LEP 2

    CERN Document Server

    Abreu, P; Adye, T; Adzic, P; Albrecht, Z; Alderweireld, T; Alekseev, G D; Alemany, R; Allmendinger, T; Allport, P P; Almehed, S; Amaldi, Ugo; Amapane, N; Amato, S; Anassontzis, E G; Andersson, P; Andreazza, A; Andringa, S; Antilogus, P; Apel, W D; Arnoud, Y; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Bambade, P; Barão, F; Barbiellini, Guido; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Beillière, P; Belokopytov, Yu A; Belous, K S; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Bertini, D; Bertrand, D; Besançon, M; Bianchi, F; Bigi, M; Bilenky, S M; Bizouard, M A; Bloch, D; Blom, H M; Bonesini, M; Bonivento, W; Boonekamp, M; Booth, P S L; Borgland, A W; Borisov, G; Bosio, C; Botner, O; Boudinov, E; Bouquet, B; Bourdarios, C; Bowcock, T J V; Boyko, I; Bozovic, I; Bozzo, M; Branchini, P; Brenke, T; Brenner, R A; Brückman, P; Brunet, J M; Bugge, L; Buran, T; Burgsmüller, T; Buschbeck, Brigitte; Buschmann, P; Cabrera, S; Caccia, M; Calvi, M; Camporesi, T; Canale, V; Carena, F; Carroll, L; Caso, Carlo; Castillo-Gimenez, M V; Cattai, A; Cavallo, F R; Chabaud, V; Chapkin, M M; Charpentier, P; Chaussard, L; Checchia, P; Chelkov, G A; Chierici, R; Chliapnikov, P V; Chochula, P; Chorowicz, V; Chudoba, J; Cieslik, K; Collins, P; Contri, R; Cortina, E; Cosme, G; Cossutti, F; Cowell, J H; Crawley, H B; Crennell, D J; Crépé, S; Crosetti, G; Cuevas-Maestro, J; Czellar, S; Davenport, Martyn; Da Silva, W; Deghorain, A; Della Ricca, G; Delpierre, P A; Demaria, N; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Min, A; De Paula, L S; Dijkstra, H; Di Ciaccio, Lucia; Dolbeau, J; Doroba, K; Dracos, M; Drees, J; Dris, M; Duperrin, A; Durand, J D; Eigen, G; Ekelöf, T J C; Ekspong, Gösta; Ellert, M; Elsing, M; Engel, J P; Erzen, B; Espirito-Santo, M C; Falk, E; Fanourakis, G K; Fassouliotis, D; Fayot, J; Feindt, Michael; Fenyuk, A; Ferrari, P; Ferrer, A; Ferrer-Ribas, E; Ferro, F; Fichet, S; Firestone, A; Flagmeyer, U; Föth, H; Fokitis, E; Fontanelli, F; Franek, B J; Frodesen, A G; Frühwirth, R; Fulda-Quenzer, F; Fuster, J A; Galloni, A; Gamba, D; Gamblin, S; Gandelman, M; García, C; Gaspar, C; Gaspar, M; Gasparini, U; Gavillet, P; Gazis, E N; Gelé, D; Ghodbane, N; Gil, I; Glege, F; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; González-Caballero, I; Gopal, Gian P; Gorn, L; Górski, M; Guz, Yu; Gracco, Valerio; Grahl, J; Graziani, E; Green, C; Grimm, H J; Gris, P; Grosdidier, G; Grzelak, K; Günther, M; Guy, J; Hahn, F; Hahn, S; Haider, S; Hallgren, A; Hamacher, K; Hansen, J; Harris, F J; Hedberg, V; Heising, S; Hernández, J J; Herquet, P; Herr, H; Hessing, T L; Heuser, J M; Higón, E; Holmgren, S O; Holt, P J; Hoorelbeke, S; Houlden, M A; Hrubec, Josef; Huet, K; Hughes, G J; Hultqvist, K; Jackson, J N; Jacobsson, R; Jalocha, P; Janik, R; Jarlskog, C; Jarlskog, G; Jarry, P; Jean-Marie, B; Johansson, E K; Jönsson, P E; Joram, C; Juillot, P; Kapusta, F; Karafasoulis, K; Katsanevas, S; Katsoufis, E C; Keränen, R; Kersevan, Borut P; Khomenko, B A; Khovanskii, N N; Kiiskinen, A P; King, B J; Kinvig, A; Kjaer, N J; Klapp, O; Klein, H; Kluit, P M; Kokkinias, P; Koratzinos, M; Kostyukhin, V; Kourkoumelis, C; Kuznetsov, O; Krammer, Manfred; Kriznic, E; Krstic, J; Krumshtein, Z; Kubinec, P; Kurowska, J; Kurvinen, K L; Lamsa, J; Lane, D W; Langefeld, P; Lapin, V; Laugier, J P; Lauhakangas, R; Leder, Gerhard; Ledroit, F; Lefébure, V; Leinonen, L; Leisos, A; Leitner, R; Lemonne, J; Lenzen, Georg; Lepeltier, V; Lesiak, T; Lethuillier, M; Libby, J; Liko, D; Lipniacka, A; Lippi, I; Lörstad, B; Loken, J G; Lopes, J H; López, J M; López-Fernandez, R; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J N; Mahon, J R; Maio, A; Malek, A; Malmgren, T G M; Maltezos, S; Malychev, V; Mandl, F; Marco, J; Marco, R P; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Martínez-Vidal, F; Martí i García, S; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Matthiae, Giorgio; Masik, J; Mazzucato, F; Mazzucato, M; McCubbin, M L; McKay, R; McNulty, R; McPherson, G; Meroni, C; Meyer, W T; Migliore, E; Mirabito, L; Mitaroff, Winfried A; Mjörnmark, U; Moa, T; Moch, M; Møller, R; Mönig, K; Monge, M R; Moreau, X; Morettini, P; Morton, G A; Müller, U; Münich, K; Mulders, M; Mulet-Marquis, C; Muresan, R; Murray, W J; Muryn, B; Myatt, Gerald; Myklebust, T; Naraghi, F; Nassiakou, M; Navarria, Francesco Luigi; Navas, S; Nawrocki, K; Negri, P; Némécek, S; Neufeld, N; Neumeister, N; Nicolaidou, R; Nielsen, B S; Nikolenko, M; Nomokonov, V P; Normand, Ainsley; Nygren, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, Risto; Orazi, G; Österberg, K; Ouraou, A; Paganoni, M; Paiano, S; Pain, R; Paiva, R; Palacios, J; Palka, H; Papadopoulou, T D; Papageorgiou, K; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Pegoraro, M; Peralta, L; Pernicka, Manfred; Perrotta, A; Petridou, C; Petrolini, A; Phillips, H T; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Privitera, P; Pukhaeva, N; Pullia, Antonio; Radojicic, D; Ragazzi, S; Rahmani, H; Ratoff, P N; Read, A L; Rebecchi, P; Redaelli, N G; Regler, Meinhard; Reid, D; Reinhardt, R; Renton, P B; Resvanis, L K; Richard, F; Rídky, J; Rinaudo, G; Røhne, O M; Romero, A; Ronchese, P; Rosenberg, E I; Rosinsky, P; Roudeau, Patrick; Rovelli, T; Royon, C; Ruhlmann-Kleider, V; Ruiz, A; Saarikko, H; Sacquin, Yu; Sadovskii, A; Sajot, G; Salt, J; Sampsonidis, D; Sannino, M; Schneider, H; Schwemling, P; Schwering, B; Schwickerath, U; Schyns, M A E; Scuri, F; Seager, P; Sedykh, Yu; Segar, A M; Sekulin, R L; Shellard, R C; Sheridan, A; Siebel, M; Simard, L C; Simonetto, F; Sissakian, A N; Smadja, G; Smirnov, N; Smirnova, O G; Smith, G R; Sopczak, André; Sosnowski, R; Spassoff, Tz; Spiriti, E; Sponholz, P; Squarcia, S; Stanescu, C; Stanic, S; Stevenson, K; Stocchi, A; Strub, R; Stugu, B; Szczekowski, M; Szeptycka, M; Tabarelli de Fatis, T; Tegenfeldt, F; Terranova, F; Thomas, J; Timmermans, J; Tinti, N; Tkatchev, L G; Todorova-Nová, S; Tomaradze, A G; Tomé, B; Tonazzo, A; Tortora, L; Tranströmer, G; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Tsirou, A L; Turluer, M L; Tyapkin, I A; Tzamarias, S; Ullaland, O; Uvarov, V; Valenti, G; Vallazza, E; Van der Velde, C; van Apeldoorn, G W; van Dam, P; Van Doninck, W K; Van Eldik, J; Van Lysebetten, A; Van Vulpen, I B; Vassilopoulos, N; Vegni, G; Ventura, L; Venus, W A; Verbeure, F; Verlato, M; Vertogradov, L S; Verzi, V; Vilanova, D; Vitale, L; Vlasov, E; Vodopyanov, A S; Vollmer, C F; Voulgaris, G; Vrba, V; Wahlen, H; Walck, C; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G R; Winter, M; Witek, M; Wolf, G; Yi, J; Yushchenko, O P; Zaitsev, A; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zevgolatakos, E; Zimin, N I; Zucchelli, G C; Zumerle, G

    1999-01-01

    Infrared and collinear safe event shape distributions and their mean values are determined using the data taken at ve di erent centre of mass energies above $M_Z$ with the DELPHI detector at LEP. From the event shapes, the strong coupling $\\alpha_s$ is extracted in $O(\\alpha^2_s)$, NLLA and a combined scheme using hadronisation corrections evaluated with fragmentation model generators as well as using an analytical power ansatz. Comparing these measurements to those obtained at MZ, the energy dependence (running) of $\\alpha_s$ is accessible. The logarithmic energy slope of the inverse strong coupling is measured to be $d\\alpha_{s}^{-1}/d log(E_{cm}) = 1.39 \\pm 0.34(stat) \\pm 0.17(syst)$, in good agreement with the QCD expectation of 1.27.

  5. Perturbative expansion of tau hadronic spectral function moments and alpha_s extractions

    CERN Document Server

    Beneke, Martin; Jamin, Matthias

    2012-01-01

    Various moments of the hadronic spectral functions have been employed in the determination of the strong coupling alpha_s from tau decays. In this work we study the behaviour of their perturbative series under different assumptions for the large-order behaviour of the Adler function, extending previous work on the tau hadronic width. We find that the moments can be divided into a small number of classes, whose characteristics depend only on generic features of the moment weight function and Adler function series. Some moments that are commonly employed in alpha_s analyses from tau decays should be avoided because of their perturbative instability. This conclusion is corroborated by a simplified alpha_s extraction from individual moments. Furthermore, under reasonable assumptions for the higher-order behaviour of the perturbative series, fixed-order perturbation theory (FOPT) provides the preferred framework for the renormalization group improvement of all moments that show good perturbative behaviour. Finally...

  6. Note on Two Generalizations of Coefficient Alpha.

    Science.gov (United States)

    Raju, Nambury S.

    1979-01-01

    An important relationship is given for two generalizations of coefficient alpha: (1) Rajaratnam, Cronbach, and Gleser's generalizability formula for stratified-parallel tests, and (2) Raju's coefficient beta. (Author/CTM)

  7. Solar Imagery - Chromosphere - H-Alpha

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Collection includes a variety of H-alpha photographic datasets contributed by a number of national and private solar observatories located worldwide. Solar...

  8. T-branes and $\\alpha'$-corrections

    CERN Document Server

    Marchesano, Fernando

    2016-01-01

    We study $\\alpha'$-corrections in multiple D7-brane configurations with non-commuting profiles for their transverse position fields. We focus on T-brane systems, crucial in F-theory GUT model building. There $\\alpha'$-corrections modify the D-term piece of the BPS equations which, already at leading order, require a non-primitive Abelian worldvolume flux background. We find that $\\alpha'$-corrections may either i) leave this flux background invariant, ii) modify the Abelian non-primitive flux profile, or iii) deform it to a non-Abelian profile. The last case typically occurs when primitive fluxes, a necessary ingredient to build 4d chiral models, are added to the system. We illustrate these three cases by solving the $\\alpha'$-corrected D-term equations in explicit examples, and describe their appearance in more general T-brane backgrounds. Finally, we discuss implications of our findings for F-theory GUT local models.

  9. High resolution alpha particle spectrometry through collimation

    International Nuclear Information System (INIS)

    Alpha particle spectrometry with collimation is a useful method for identifying nuclear materials among various nuclides. A mesh type collimator reduces the low energy tail and broadened energy distribution by cutting off particles with a low incidence angle. The relation between the resolution and the counting efficiency can be investigated by changing a ratio of the mesh hole diameter and the collimator thickness. Through collimation, a target particle can be distinguished by a PIPS® detector under a mixture of various nuclides. - Highlights: • Alpha particle spectrometry with collimation a useful method for identifying nuclear materials among various radionuclides. • A collimator cut off alpha particles with low angle emitted from a source. • We confirm that that a collimator improves the resolution of alpha spectra through both simulation and experiments

  10. Alpha thalassaemia-mental retardation, X linked

    OpenAIRE

    Gibbons Richard

    2006-01-01

    Abstract X-linked alpha thalassaemia mental retardation (ATR-X) syndrome in males is associated with profound developmental delay, facial dysmorphism, genital abnormalities and alpha thalassaemia. Female carriers are usually physically and intellectually normal. So far, 168 patients have been reported. Language is usually very limited. Seizures occur in about one third of the cases. While many patients are affectionate with their caregivers, some exhibit autistic-like behaviour. Patients pres...

  11. Self-assembling, dynamic alphaPNAs

    DEFF Research Database (Denmark)

    Nielsen, Peter E

    2009-01-01

    In the recent report published in Science, Ghadiri and coworkers describe dynamic tPNAs, alphaPNA derivatives with a nucleobase attached via a thioester bond that are a step forward toward self-repairing and replicating molecules.......In the recent report published in Science, Ghadiri and coworkers describe dynamic tPNAs, alphaPNA derivatives with a nucleobase attached via a thioester bond that are a step forward toward self-repairing and replicating molecules....

  12. Scaling Property in the Alpha Predominant EEG

    CERN Document Server

    Lin, D C; Kwan, H; Lin, Der Chyan; Sharif, Asif; Kwan, Hon

    2004-01-01

    The $\\alpha$ predominant electroencephalographic (EEG) recording of the human brain during eyes open and closed is studied using the zero-crossing time statistics. A model is presented to demonstrate and compare the key characteristics of the brain state. We found the zero-crossing time statistic is more accurate than the power spectral analysis and the detrend fluctuation analysis. Our results indicate different EEG fractal scaling in eyes closed and open for individuals capable of strong $\\alpha$ rhythm.

  13. Alpha-emitters for medical therapy workshop

    Energy Technology Data Exchange (ETDEWEB)

    Feinendegen, L.E.; McClure, J.J.

    1996-12-31

    A workshop on ``Alpha-Emitters for Medical Therapy`` was held May 30-31, 1996 in Denver Colorado to identify research goals and potential clinical needs for applying alpha-particle emitters and to provide DOE with sufficient information for future planning. The workshop was attended by 36 participants representing radiooncology, nuclear medicine, immunotherapy, radiobiology, molecular biology, biochemistry, radiopharmaceutical chemistry, dosimetry, and physics. This report provides a summary of the key points and recommendations arrived at during the conference.

  14. Neurophysiological assessment of alpha pattern coma.

    OpenAIRE

    Obeso, J A; Iragui, M I; Marti-Masso, J. F.; Maravi, E; Teijeira, J M; Carrera, N; Teijeria, J

    1980-01-01

    Somatosensory evoked potentials, blink reflexes, and H wave reflexes, were recorded on several days from three patients with alpha pattern coma. Coma was secondary to cardiac arrest in two cases and to brainstem infarction in one. Results are compatible with damage to the brainstem reticular formation with sparing of thalamo-cortical circuits as the main physiopathological characteristic of alpha pattern coma. This condition should not be regarded as a discrete entity when establishing the pr...

  15. Remote Associates Test and Alpha Brain Waves

    OpenAIRE

    Haarmann, Henk J.; George, Timothy; Smaliy, Alexei; Dien, Joseph

    2012-01-01

    Previous studies found that performance on the remote associates test (RAT) improves after a period of incubation and that increased alpha brain waves over the right posterior brain predict the emergence of RAT insight solutions. We report an experiment that tested whether increased alpha brain waves during incubation improve RAT performance. Participants received two blocks of RAT items (RAT1 and RAT2), with the second block consisting of items that were not solved during the first block. Pa...

  16. Lectin interactions with alpha-galactosylated xenoantigens

    DEFF Research Database (Denmark)

    Kirkeby, Svend; Moe, Dennis

    2002-01-01

    alpha-Galactosylated xenoantigens (Galalpha1-3Galbeta1-4GlcNAcbeta1 and Galalpha1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc) are often detected with the alpha-Gal specific lectin Griffonia simplicifolia 1 isolectin B4 (GS1 B4). However, this lectin exhibits a broad and variable specificity for carboh...

  17. Different polyphenolic components of soft fruits inhibit alpha-amylase and alpha-glucosidase.

    Science.gov (United States)

    McDougall, Gordon J; Shpiro, Faina; Dobson, Patricia; Smith, Pauline; Blake, Alison; Stewart, Derek

    2005-04-01

    Polyphenol-rich extracts from soft fruits were tested for their ability to inhibit alpha-amylase and alpha-glucosidase. All extracts tested caused some inhibition of alpha-amylase, but there was a 10-fold difference between the least and most effective extracts. Strawberry and raspberry extracts were more effective alpha-amylase inhibitors than blueberry, blackcurrant, or red cabbage. Conversely, alpha-glucosidase was more readily inhibited by blueberry and blackcurrant extracts. The extent of inhibition of alpha-glucosidase was related to their anthocyanin content. For example, blueberry and blackcurrant extracts, which have the highest anthocyanin content, were the most effective inhibitors of alpha-glucosidase. The extracts most effective in inhibiting alpha-amylase (strawberry and raspberry) contain appreciable amounts of soluble tannins. Other tannin-rich extracts (red grape, red wine, and green tea) were also effective inhibitors of alpha-amylase. Indeed, removing tannins from strawberry extracts with gelatin also removed inhibition. Fractionation of raspberry extracts on Sephadex LH-20 produced an unbound fraction enriched in anthocyanins and a bound fraction enriched in tannin-like polyphenols. The unbound anthocyanin-enriched fraction was more effective against alpha-glucosidase than the original extract, whereas the alpha-amylase inhibitors were concentrated in the bound fraction. The LH-20 bound sample was separated by preparative HPLC, and fractions were assayed for inhibition of alpha-amylase. The inhibitory components were identified as ellagitannins using LC-MS-MS. This study suggests that different polyphenolic components of fruits may influence different steps in starch digestion in a synergistic manner. PMID:15796622

  18. Modified equipartition calculation for supernova remnants. Cases \\alpha =0.5 and \\alpha =1

    CERN Document Server

    Arbutina, B; Vucetic, M M; Pavlovic, M Z; Vukotic, B

    2013-01-01

    The equipartition or minimum-energy calculation is a well-known procedure for estimating magnetic field strength and total energy in the magnetic field and cosmic ray particles by using only the radio synchrotron emission. In one of our previous papers we have offered a modified equipartition calculation for supernova remnants (SNRs) with spectral indices 0.5<\\alpha <1. Here we extend the analysis to SNRs with \\alpha =0.5 and \\alpha =1.

  19. Therapeutic use of alpha-emitters

    Energy Technology Data Exchange (ETDEWEB)

    Lassmann, M. [Klinik und Poliklinik fuer Nuklearmedizin der Univ. Wuerzburg (Germany)

    2005-07-01

    In recent years there is a growing interest in the therapeutic use of {alpha}-emitters for patient treatment, {alpha}-particles have much higher energy and their range is only a few cell diameters. Their high LET and the limited ability of cells to repair DNA damage from {alpha}-radiation explain their high relative biological effectiveness and cytotoxicity. Potential {alpha}-emitting isotopes for therapeutic applications are {sup 224}Ra, {sup 223}Ra, {sup 213}Bi and {sup 211}At. The treatment with {alpha}-particles is focused upon targeted cancer therapy using radiolabeled monoclonal antibodies, on palliation of bone metastases or upon pain relief in patients with ankylosing spondylitis (AS). Examples for targeted cancer therapy are the treatment of melanoma with {sup 213}Bi and non-Hodgkin lymphoma with {sup 211}At. For metastatic bone pain palliation {sup 223}Ra was applied in a phase I clinical trial. For amelioration of pain in AS-patients {sup 224}Ra-chloride is used. This radiopharmaceutical is licensed for this particular application in Germany. Today there are some potential clinical applications for {alpha}-emitters although most of them are in the state of scientific, non-routine investigations. In-vivo dosimetry for risk assessment associated with this treatment is even more difficult to perform than for therapies using beta-emitting radiopharmaceuticals. (orig.)

  20. Alpha-dispersion in human tissue

    Science.gov (United States)

    Grimnes, Sverre; Martinsen, Ørjan G.

    2010-04-01

    Beta dispersion is found in living tissue in the kilohertz - megahertz range and is caused by the cellular structure of biological materials with low frequency properties caused by cell membranes. Alpha dispersion is found in the hertz range and the causes are not so well known. Alpha dispersions are the first to disappear when tissue dies. Tissue data have often been based upon excised specimen from animals and are therefore not necessarily representative for human tissue alpha dispersions. Here we present data obtained with non-invasive skin surface electrodes for different segments of the living human body. We found alpha dispersions in all cases; the ankle-wrist results had the smallest. Large alpha dispersions were found where the distance between the electrodes and muscle masses was small, e.g. on the calf. Further studies on electrode technique and reciprocity, electrode positioning, statistical variations, gender, age and bodily constitutions are necessary in order to reveal more about the alpha dispersion, its appearance and disappearance.

  1. Alpha nuclides in nuclear power plants

    International Nuclear Information System (INIS)

    In a joint research project of VGB and AREVA NP GmbH the behavior of alpha nuclides in nuclear power plants has been investigated since 2005. The main source of alpha nuclides is core contamination with fissile material (so called tramp uranium or tramp fuel) which deposits on fuel rod surfaces and leads to the build-up of transuranium nuclides. Such alpha-nuclides are of special interest for health physics due to their high biological effectiveness. Having very high dose factors they lead to high dose weighting in case of incorporation. At NPC 2008 first results of the joint research project were presented concerning tramp fuel and its impact to alpha nuclides. The present publication will cover the ongoing results of this research project. A special focus is taken to deduce recommendations which allow plant operation personal to recognize situations in advance which can lead to enhanced appearance of alpha nuclides. Depending on the fuel conditions in the core and the activity level of fission products of the reactor coolant a better prediction of the alpha situation at the following outage and maintenance can be deduced. (author)

  2. [Alpha-1 antitrypsin deficiency: diagnosis and treatment].

    Science.gov (United States)

    Camelier, Aquiles A; Winter, Daniel Hugo; Jardim, José Roberto; Barboza, Carlos Eduardo Galvão; Cukier, Alberto; Miravitlles, Marc

    2008-07-01

    Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SERPINA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. The mutation most commonly associated with the clinical disease is the Z allele, which causes polymerization and accumulation within hepatocytes. The accumulation of and the consequent reduction in the serum levels of alpha-1 antitrypsin cause, respectively, liver and lung disease, the latter occurring mainly as early emphysema, predominantly in the lung bases. Diagnosis involves detection of low serum levels of alpha-1 antitrypsin as well as phenotypic confirmation. In addition to the standard treatment of chronic obstructive pulmonary disease, specific therapy consisting of infusion of purified alpha-1 antitrypsin is currently available. The clinical efficacy of this therapy, which appears to be safe, has yet to be definitively established, and its cost-effectiveness is also a controversial issue that is rarely addressed. Despite its importance, in Brazil, there are no epidemiological data on the prevalence of the disease or the frequency of occurrence of deficiency alleles. Underdiagnosis has also been a significant limitation to the study of the disease as well as to appropriate treatment of patients. It is hoped that the creation of the Alpha One International Registry will resolve these and other important issues. PMID:18695797

  3. H-alpha features with hot onsets III. Fibrils in Lyman-alpha and with ALMA

    CERN Document Server

    Rutten, Robert J

    2016-01-01

    In H-alpha most of the solar surface is covered by a dense canopy of long opaque fibrils, but predictions for quiet-Sun observations with ALMA have ignored this fact. Comparison with Ly-alpha suggests that the large opacity of H-alpha fibrils is caused by hot precursor events. Application of a recipe that assumes momentary Saha-Boltzmann extinction during their hot onset to millimeter wavelengths suggests that ALMA will observe the H-alpha fibril canopy, not acoustic shocks underneath, and will yield data more interesting than if this canopy were transparent.

  4. Peginterferon alpha-2a versus peginterferon alpha-2b for chronic hepatitis C

    DEFF Research Database (Denmark)

    Hauser, Goran; Awad, Tahany; Thorlund, Kristian;

    2014-01-01

    evidence suggests that peginterferon alpha-2a is associated with a higher sustained virological response in serum than with peginterferon alpha-2b. This finding may be affected by the high risk of bias of the included studies . The clinical consequences of peginterferon alpha-2a versus peginterferon alpha......-2b are unknown, and we cannot translate an effect on sustained virological response into comparable clinical effects because sustained virological response is still an unvalidated surrogate outcome for patient-important outcomes. The lack of evidence on patient-important outcomes and the paucity...

  5. Alpha 1-blockers vs 5 alpha-reductase inhibitors in benign prostatic hyperplasia. A comparative review

    DEFF Research Database (Denmark)

    Andersen, J T

    1995-01-01

    During recent years, pharmacological treatment of symptomatic benign prostatic hyperplasia (BPH) has become the primary treatment choice for an increasing number of patients. The 2 principal drug classes employed are alpha 1-blockers and 5 alpha-reductase inhibitors. Current information from...... of patients who will respond well to alpha 1-blockers have yet to be identified, and data concerning the long term effects of these drugs are not yet available. 5 alpha-Reductase inhibitors have a slow onset of effect, but treatment leads to improvement in symptoms, reduction of the size of the prostate gland...

  6. The Lyman alpha reference sample. VII. Spatially resolved H$\\alpha$ kinematics

    CERN Document Server

    Herenz, Edmund Christian; Orlitova, Ivana; Hayes, Matthew; Östlin, Göran; Cannon, John M; Roth, Martin M; Bik, Arjan; Pardy, Stephen; Otí-Floranes, Héctor; Mas-Hesse, J Miguel; Adamo, Angela; Atek, Hakim; Duval, Florent; Guaita, Lucia; Kunth, Daniel; Laursen, Peter; Melinder, Jens; Puschnig, Johannes; Rivera-Thorsen, Thøger E; Schaerer, Daniel; Verhamme, Anne

    2015-01-01

    We present integral field spectroscopic observations with the Potsdam Multi Aperture Spectrophotometer of all 14 galaxies in the $z\\sim 0.1$ Lyman Alpha Reference Sample (LARS). We produce 2D line of sight velocity maps and velocity dispersion maps from the Balmer $\\alpha$ (H$\\alpha$) emission in our data cubes. These maps trace the spectral and spatial properties of the LARS galaxies' intrinsic Ly$\\alpha$ radiation field. We show our kinematic maps spatially registered onto the Hubble Space Telescope H$\\alpha$ and Lyman $\\alpha$ (Ly$\\alpha$) images. Only for individual galaxies a causal connection between spatially resolved H$\\alpha$ kinematics and Ly$\\alpha$ photometry can be conjectured. However, no general trend can be established for the whole sample. Furthermore, we compute non-parametric global kinematical statistics -- intrinsic velocity dispersion $\\sigma_0$, shearing velocity $v_\\mathrm{shear}$, and the $v_\\mathrm{shear}/\\sigma_0$ ratio -- from our kinematic maps. In general LARS galaxies are charac...

  7. On Cronbach’s Alpha as the Mean of All Possible k-Split Alphas

    OpenAIRE

    Matthijs J. Warrens

    2014-01-01

    Coefficient alpha is the most commonly used internal consistency reliability coefficient. Alpha is the mean of all possible k-split alphas if the items are divided into k parts of equal size. This result gives proper interpretations of alpha: interpretations that also hold if (some of) its assumptions are not valid. Here we consider the cases where the items cannot be split into parts of equal size. It is shown that if a k-split is made such that the items are divided as evenly as possible, t...

  8. Synthesis of tritiated 1-alpha-methadol and 1-alpha-acetylmethadol

    Energy Technology Data Exchange (ETDEWEB)

    Thang, D.C.; Nam, N.H.; Pontikis, R. (Institut National de la Sante et de la Recherche Medicale (INSERM), Hopital Fernand Widal, 75 - Paris (France)); Pichat, L. (CEA Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France). Service des Molecules Marquees)

    1982-04-01

    dl-Methadone was resolved by crystallization of its ammonium d- ..cap alpha.. -bromocamphor-..pi..-sulfonate salt to give d-methadone. The latter in ethyl acetate solution was reduced with tritium gas to 1-..cap alpha..-methadol /sup 3/H in presence of Adams platinum oxide at normal temperature and pressure. Acetylation of 1-..cap alpha..-carbinol hydrochloride by means of acetyl chloride afforded 1-..cap alpha..-acetylmethadol /sup 3/H, specific activity: 20 Ci/mMole. The positions and extent of tritium labelling were determined by /sup 3/H NMR spectroscopy.

  9. Pedro Teixeira y su viaje por Mesopotamia

    Directory of Open Access Journals (Sweden)

    Fuente del Pilar, José Javier

    2005-04-01

    Full Text Available Pedro Teixeira es un integrante notable de la ilustre nómina de los viajeros portugueses que, a finales del s, XVI y principios del XVII, ensancharon para Occidente las fronteras del mundo. Su conocimiento en España se debe a la publicación en 1994 de su obra «Relaciones del Origen, Descendencia y Sucesión de los Reyes de Persia, y de Harmuz, y de un viaje hecho por el autor dende la India hasta Italia por tierra», en edición realizada por el profesor Eduardo Barajas Sala, lamentablemente fallecido en 1997. En este artículo se ofrece una reseña biográfica de Pedro Teixeira, y un análisis del viaje narrado por el autor en la última parte de sus «Relaciones »: el que desde Ormuz le conducirá, a través de Mesopotamia, hasta la costa del Mediterráneo.…

  10. Dermatoses provocadas por plantas (fitodermatoses Dermatosis due to plants (phytodermatosis

    Directory of Open Access Journals (Sweden)

    Vitor Manoel Silva dos Reis

    2010-08-01

    Full Text Available As dermatoses causadas por plantas são relativamente comuns no nosso meio e podem ocorrer por diversos mecanismos patogênicos. São descritas dermatoses por trauma físico, por ação farmacológica, mediadas por IgE, por irritação, por ação conjunta da luz e por sensibilização. Também são descritas na introdução desta revisão as pseudofitodermatoses causadas por elementos veiculados pelas plantas e, por isso, aparentemente causadas pelas plantas.Dermatosis caused by plants is relatively common and may occur by various pathogenic mechanisms. Dermatitis due to physical trauma, pharmacological action, irritation, sensitization, mediated by IgE and induced by light are described. Pseudophytodermatosis caused by plant-delivered elements is also described in the introduction to this work.

  11. Anti-IL-1alpha autoantibodies in early rheumatoid arthritis

    DEFF Research Database (Denmark)

    Forslind, K; Svensson, Birte; Svenson, M;

    2001-01-01

    To investigate the potential predictive value of autoantibodies against IL1-alpha (anti-IL-1alpha) in patients with early rheumatoid arthritis (RA).......To investigate the potential predictive value of autoantibodies against IL1-alpha (anti-IL-1alpha) in patients with early rheumatoid arthritis (RA)....

  12. In vitro anti-inflammatory activities of new steroidal antedrugs: [16alpha,17alpha-d] Isoxazoline and [16alpha,17alpha-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of prednisolone and 9alpha-fluoroprednisolone.

    Science.gov (United States)

    Park, Kwan-K; Ko, Dong-H; You, Z; Khan, M Omar F; Lee, Henry J

    2006-03-01

    A series of new anti-inflammatory steroidal antedrugs with C-16,17-isoxazoline ring system were synthesized and their pharmacological activities were evaluated. We reported earlier that these compounds are promising antedrugs based on the results of 5-day rat croton oil ear edema assay. In the present study, most of these compounds showed high binding affinities to the glucocorticoid receptor of liver cytosol. 21-acetyloxy-9alpha-fluoro-11beta-hydroxy-3,20-dioxo-1,4-pregnadieno [16alpha,17alpha-d] isoxazoline (FP-ISO-21AC) and 11beta,21-dihydroxy-9alpha-fluoro-3,20-dioxo-1,4-pregnadieno [16alpha,17alpha-d] isoxazoline (FP-ISO-21OH) were found 5.0-, 5.3-fold more potent than prednisolone, respectively. Inhibitory effects of the antedrugs on the nitric oxide (NO) production were assessed using LPS-stimulated RAW 264.7 murine macrophage cells. All these steroidal antedrugs exhibited concentration-dependent inhibition of NO production, but their relative potencies were lower than prednisolone. In vitro metabolism study in rat plasma showed that FP-ISO-21AC and 21-acetyloxy-9alpha-fluoro-11beta-hydroxy-3,20-dioxo-1,4-pregnadieno [16alpha,17alpha-d]-3'-hydroxyiminoformyl isoxazoline (FP-OXIM-21AC) were hydrolyzed rapidly, with the half-lives of 2.1 and 4.2 min, respectively. The half-lives of FP-ISO-21OH and 11beta,21-dihydroxy-9alpha-fluoro-3,20-dioxo-1,4-pregnadieno [16alpha,17alpha-d]-3'-hydroxyiminoformyl isoxazoline (FP-OXIM-21OH) were 92.2 and 110.2 min, respectively. PMID:16309722

  13. Control de la conducta inducida por programa por sus consecuencias ambientales

    OpenAIRE

    Ardoy Cuadros, Juan

    2008-01-01

    La presente Tesis Doctoral se ha desarrollado dentro de una de las líneas de investigación desarrollada por el Departamento de Psicología Básica I de la UNED y cuyo objetivo prioritario es el estudio de las características de la conducta inducida por programa, así como el control ambiental y farmacológico de la misma. El objetivo de esta investigación, en concreto, es determinar los factores implicados en la aparición de la polidipsia inducida por programa en ratas, así como en su mantenimi...

  14. Recent advances in the discovery of alpha1-adrenoceptor agonists.

    Science.gov (United States)

    Bishop, Michael J

    2007-01-01

    The alpha(1) adrenoceptors are three of nine well-characterized receptors that are activated by epinephrine and norepinephrine. Agonists acting at the alpha(1) adrenoceptors produce numerous physiological effects, and are used therapeutically for several indications. Many known alpha(1) adrenoceptor agonists are alpha(1A) selective, but the discovery of highly selective alpha(1B) and alpha(1D) adrenoceptor agonists has proven to be an extremely difficult goal to achieve. This review will focus on recent advances in the discovery, development and clinical utility of subtype-specific alpha(1) agonists as well as contributions to our understanding of agonist-receptor interactions.

  15. Alpha Channeling in Rotating Plasma with Stationary Waves

    Energy Technology Data Exchange (ETDEWEB)

    A. Fetterman and N.J. Fisch

    2010-02-15

    An extension of the alpha channeling effect to supersonically rotating mirrors shows that the rotation itself can be driven using alpha particle energy. Alpha channeling uses radiofrequency waves to remove alpha particles collisionlessly at low energy. We show that stationary magnetic fields with high nθ can be used for this purpose, and simulations show that a large fraction of the alpha energy can be converted to rotation energy.

  16. Responsabilidad penal del empleador por delitos cometidos en la empresa por sus subordinados

    Directory of Open Access Journals (Sweden)

    Walter Jose Saavedra Troncoso

    2013-07-01

    Full Text Available En este trabajo se realiza un estudio sobre la responsabilidad penal del empresario por los actos al margen de la ley que cometen sus subordinados. Se busca aclarar si el empresario debe responder penalmente cuando el delito es cometido por un subordinado en ejercicio de sus funciones o cuando este actúa a nombre de la empresa ya sea valiéndose de la información que manejan, del grado de responsabilidad o de la confianza. Por esta razón concentraremos nuestra atención en analizar la responsabilidad penal por la omisión de controles del empresario hacia el subordinado, exponiendo la problemática que se deriva de la posición de garante del primero en las operaciones empresariales.

  17. DIATERMIA POR ONDAS CURTAS: ANÁLISE DA TEMPERATURA CORPORAL SUPERFICIAL POR TERMOGRAFIA

    OpenAIRE

    Sergio Fernando Zavarize; Anderson Martelli; Samara Aparecida Machado; Estela Maria Correia Sant’Ana

    2014-01-01

    Introdução: Poucos estudos relacionam os efeitos da diatermia por ondas curtas (DOC) e a área de aquecimento promovido por sua aplicação. Objetivo: O objetivo do trabalho foi avaliar o comportamento da temperatura superficial corporal antes e após a aplicação de DOC por meio da termografia cutânea. Materiais e métodos: A análise da temperatura corporal no local da aplicação foi realizada através da captura da imagem por meio de câmera termográfica após quinze minutos de repouso do...

  18. Responsabilidad por violación de la buena fe en la sociedad por acciones simplificada

    Directory of Open Access Journals (Sweden)

    Nicolás Polanía Tello

    2012-12-01

    Full Text Available La sociedad por acciones simplificada –SAS–, como los demás esquemas societarios, se funda en y está informada por el principio de la buena fe. Pero a diferencia de los otros modelos, la SAS tiene concreciones particulares de la buena fe que permiten un amparo más efectivo y eficiente de los derechos de los socios y de los terceros, en la medida en que instituciones como el fraude a la ley, el perjuicio injusto a terceros, el abuso del derecho y el administrador de hecho, todos estructurados a partir de violaciones a la buena fe, permiten tramitar los eventos de responsabilidad por ilícitos atípicos y llegar incluso a desestimar por ello el atributo de la limitación de responsabilidad.

  19. Crystallization and melt behaviour of isotactic poly((4-alpha,alpha-dimethyl-benzyl)phenyl methacrylate)

    NARCIS (Netherlands)

    vanEkenstein, GORA; Tan, YY

    1997-01-01

    The crystallization and melting behaviour of practically 100% isotactic poly((4-alpha,alpha-dimethylbenzyl) phenyl methacrylate) has been studied by d.s.c. and light microscopy. Crystallization from the melt seemed to be non-spherulitic. The maximum crystallization rate, which could only be determin

  20. On the Diffuse Lyman-alpha Halo Around Lyman-alpha Emitting Galaxies

    CERN Document Server

    Lake, Ethan; Cen, Renyue; Sadoun, Raphael; Momose, Rieko; Ouchi, Masami

    2015-01-01

    Ly$\\alpha$ photons scattered by neutral hydrogen atoms in the circumgalactic media or produced in the halos of star-forming galaxies are expected to lead to extended Ly$\\alpha$ emission around galaxies. Such low surface brightness Ly$\\alpha$ halos (LAHs) have been detected by stacking Ly$\\alpha$ images of high-redshift star-forming galaxies. We study the origin of LAHs by performing radiative transfer modeling of nine $z=3.1$ Lyman-Alpha Emitters (LAEs) in a high resolution hydrodynamic galaxy formation simulation. We develop a method of computing the mean Ly$\\alpha$ surface brightness profile of each LAE by effectively integrating over many different observing directions. Without adjusting any parameters, our model yields an average Ly$\\alpha$ surface brightness profile in remarkable agreement with observations. We find that observed LAHs can not be accounted for solely by photons originating from the central LAE and scattered to large radii by hydrogen atoms in the circumgalactic gas. Instead, Ly$\\alpha$ em...

  1. Upper rim {alpha}-hydroxy-or {alpha}-amino phosphonic acid derivatives of calix (4) ARENES

    Energy Technology Data Exchange (ETDEWEB)

    Markovsky, L.N.; Kalchenko, V.I.; Solovyov, A.V.; Finocchiaro, P.; Failla, S.; Atamas, L.I.; Consiglio, G.; Tsymbal, I.F. [Institute of Organic Chemistry National Academy of Sciences of Ukraine (Ukraine)

    1998-10-01

    The synthesis and some stereochemical peculiarities of calix (4) arenes bearing at the upper rim of macrocycle alpha-hydroxy or alpha-amino phosphonic acid dialkyl ester fragments are described. The formation of the dimeric associates induced by intermolecular hydrogen bonds CH-OH...O=P has been also studied. (Author) 24 refs.

  2. Consistent Measurements of $\\alpha_{s}$ from Precise Oriented Event Shape Distributions

    CERN Document Server

    Abreu, P; Adye, T; Adzic, P; Albrecht, Z; Alderweireld, T; Alekseev, G D; Alemany, R; Allmendinger, T; Allport, P P; Almehed, S; Amaldi, Ugo; Amapane, N; Amato, S; Anassontzis, E G; Andersson, P; Andreazza, A; Andringa, S; Antilogus, P; Apel, W D; Arnoud, Y; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Bambade, P; Barão, F; Barbiellini, Guido; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Beillière, P; Belokopytov, Yu A; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Bertini, D; Bertrand, D; Besançon, M; Bigi, M; Bilenky, S M; Bizouard, M A; Bloch, D; Blom, H M; Bonesini, M; Bonivento, W; Boonekamp, M; Booth, P S L; Borgland, A W; Borisov, G; Bosio, C; Botner, O; Boudinov, E; Bouquet, B; Bourdarios, C; Bowcock, T J V; Boyko, I; Bozovic, I; Bozzo, M; Branchini, P; Brenke, T; Brenner, R A; Brückman, P; Brunet, J M; Bugge, L; Buran, T; Burgsmüller, T; Buschbeck, Brigitte; Buschmann, P; Cabrera, S; Caccia, M; Calvi, M; Camporesi, T; Canale, V; Carena, F; Carroll, L; Caso, Carlo; Castillo-Gimenez, M V; Cattai, A; Cavallo, F R; Chabaud, V; Charpentier, P; Chaussard, L; Checchia, P; Chelkov, G A; Chierici, R; Chochula, P; Chorowicz, V; Chudoba, J; Cieslik, K; Collins, P; Contri, R; Cortina, E; Cosme, G; Cossutti, F; Cowell, J H; Crawley, H B; Crennell, D J; Crépé, S; Crosetti, G; Cuevas-Maestro, J; Czellar, S; Davenport, Martyn; Da Silva, W; Deghorain, A; Della Ricca, G; Delpierre, P A; Demaria, N; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Min, A; De Paula, L S; Dijkstra, H; Di Ciaccio, Lucia; Dolbeau, J; Doroba, K; Dracos, M; Drees, J; Dris, M; Duperrin, A; Durand, J D; Eigen, G; Ekelöf, T J C; Ekspong, Gösta; Ellert, M; Elsing, M; Engel, J P; Erzen, B; Espirito-Santo, M C; Fanourakis, G K; Fassouliotis, D; Fayot, J; Feindt, Michael; Ferrari, P; Ferrer, A; Ferrer-Ribas, E; Ferro, F; Fichet, S; Firestone, A; Flagmeyer, U; Föth, H; Fokitis, E; Fontanelli, F; Franek, B J; Frodesen, A G; Frühwirth, R; Fulda-Quenzer, F; Fuster, J A; Galloni, A; Gamba, D; Gamblin, S; Gandelman, M; García, C; Gaspar, C; Gaspar, M; Gasparini, U; Gavillet, P; Gazis, E N; Gelé, D; Ghodbane, N; Gil, I; Glege, F; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; González-Caballero, I; Gopal, Gian P; Gorn, L; Gracco, Valerio; Grahl, J; Graziani, E; Green, C; Grimm, H J; Gris, P; Grosdidier, G; Grzelak, K; Günther, M; Guy, J; Hahn, F; Hahn, S; Haider, S; Hallgren, A; Hamacher, K; Hansen, J; Harris, F J; Hedberg, V; Heising, S; Hernández, J J; Herquet, P; Herr, H; Hessing, T L; Heuser, J M; Higón, E; Holmgren, S O; Holt, P J; Hoorelbeke, S; Houlden, M A; Hrubec, Josef; Huet, K; Hughes, G J; Hultqvist, K; Jackson, J N; Jacobsson, R; Jalocha, P; Janik, R; Jarlskog, C; Jarlskog, G; Jarry, P; Jean-Marie, B; Johansson, E K; Jönsson, P E; Joram, C; Juillot, P; Kapusta, F; Karafasoulis, K; Katsanevas, S; Katsoufis, E C; Keränen, R; Kersevan, Borut P; Khomenko, B A; Khovanskii, N N; Kiiskinen, A P; King, B J; Kinvig, A; Kjaer, N J; Klapp, O; Klein, H; Kluit, P M; Kokkinias, P; Koratzinos, M; Kourkoumelis, C; Kuznetsov, O; Krammer, Manfred; Kriznic, E; Krumshtein, Z; Kubinec, P; Kurowska, J; Kurvinen, K L; Lamsa, J; Lane, D W; Langefeld, P; Laugier, J P; Lauhakangas, R; Leder, Gerhard; Ledroit, F; Lefébure, V; Leinonen, L; Leisos, A; Leitner, R; Lemonne, J; Lenzen, Georg; Lepeltier, V; Lesiak, T; Lethuillier, M; Libby, J; Liko, D; Lipniacka, A; Lippi, I; Lörstad, B; Loken, J G; Lopes, J H; López, J M; López-Fernandez, R; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J N; Mahon, J R; Maio, A; Malek, A; Malmgren, T G M; Maltezos, S; Malychev, V; Mandl, F; Marco, J; Marco, R P; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Martínez-Vidal, F; Martí i García, S; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Matthiae, Giorgio; Mazzucato, F; Mazzucato, M; McCubbin, M L; McKay, R; McNulty, R; McPherson, G; Meroni, C; Meyer, W T; Migliore, E; Mirabito, L; Mitaroff, Winfried A; Mjörnmark, U; Moa, T; Moch, M; Møller, R; Mönig, K; Monge, M R; Moreau, X; Morettini, P; Morton, G A; Müller, U; Münich, K; Mulders, M; Mulet-Marquis, C; Muresan, R; Murray, W J; Muryn, B; Myatt, Gerald; Myklebust, T; Naraghi, F; Nassiakou, M; Navarria, Francesco Luigi; Navas, S; Nawrocki, K; Negri, P; Némécek, S; Neufeld, N; Nicolaidou, R; Nielsen, B S; Niezurawski, P; Nikolenko, M; Nomokonov, V P; Normand, Ainsley; Nygren, A; Olshevskii, A G; Onofre, A; Orava, Risto; Orazi, G; Österberg, K; Ouraou, A; Paganoni, M; Paiano, S; Pain, R; Paiva, R; Palacios, J; Palka, H; Papadopoulou, T D; Papageorgiou, K; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Pegoraro, M; Peralta, L; Pernicka, Manfred; Perrotta, A; Petridou, C; Petrolini, A; Phillips, H T; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Privitera, P; Pukhaeva, N; Pullia, Antonio; Radojicic, D; Ragazzi, S; Rahmani, H; Ratoff, P N; Read, A L; Rebecchi, P; Redaelli, N G; Regler, Meinhard; Reid, D; Reinhardt, R; Renton, P B; Resvanis, L K; Richard, F; Rídky, J; Rinaudo, G; Rodrigo, Germán; Røhne, O M; Romero, A; Ronchese, P; Rosenberg, E I; Rosinsky, P; Roudeau, Patrick; Rovelli, T; Royon, C; Ruhlmann-Kleider, V; Ruiz, A; Saarikko, H; Sacquin, Yu; Sadovskii, A; Sajot, G; Salt, J; Sampsonidis, D; Sannino, M; Schneider, H; Schwemling, P; Schwering, B; Schwickerath, U; Schyns, M A E; Scuri, F; Seager, P; Sedykh, Yu; Segar, A M; Sekulin, R L; Shellard, R C; Sheridan, A; Siebel, M; Simard, L C; Simonetto, F; Sissakian, A N; Smadja, G; Smirnova, O G; Smith, G R; Sopczak, André; Sosnowski, R; Spassoff, Tz; Spiriti, E; Sponholz, P; Squarcia, S; Stanescu, C; Stanic, S; Stevenson, K; Stocchi, A; Strauss, J; Strub, R; Stugu, B; Szczekowski, M; Szeptycka, M; Tabarelli de Fatis, T; Tegenfeldt, F; Terranova, F; Thomas, J; Timmermans, J; Tinti, N; Tkatchev, L G; Todorova-Nová, S; Tomaradze, A G; Tomé, B; Tonazzo, A; Tortora, L; Tranströmer, G; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Tsirou, A L; Turluer, M L; Tyapkin, I A; Tzamarias, S; Ullaland, O; Valenti, G; Vallazza, E; Van der Velde, C; van Apeldoorn, G W; van Dam, P; Van Doninck, W K; Van Eldik, J; Van Lysebetten, A; Van Remortel, N; Van Vulpen, I B; Vassilopoulos, N; Vegni, G; Ventura, L; Venus, W A; Verbeure, F; Verlato, M; Vertogradov, L S; Verzi, V; Vilanova, D; Vitale, L; Vodopyanov, A S; Vollmer, C F; Voulgaris, G; Vrba, V; Wahlen, H; Walck, C; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G R; Winter, M; Witek, M; Wolf, G; Yi, J; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zevgolatakos, E; Zimin, N I; Zucchelli, G C; Zumerle, G

    2000-01-01

    An updated analysis using about 1.5 million events recorded at $\\sqrt{s} =M_Z$ with the DELPHI detector in 1994 is presented. Eighteen infrared and collinear safe event shape observables are measured as a function of the polar angle of the thrust axis. The data are compared to theoretical calculations in${\\cal O} (\\alpha_s^2)$ including the event orientation. A combined fit of $\\alpha_s$ and of the renormalization scale $x_{\\mu}$ in $\\cal O(\\alpha_s^2$)yields an excellent description of the high statistics data. The weighted average from 18 observables including quark mass effects and correlations is $\\alpha_s(M_Z^2) = 0.1174 \\pm 0.0026$. The final result, derived from the jet cone energy fraction, the observable with the smallest theoretical and experimental uncertainty, is $\\alpha_s(M_Z^2) = =0:1180 0:0006(exp:) 0:0013(hadr:) 0:0008(scale) 0:0007(mass). Further studies include an s determination using theoretical predictions in the next-to-leading log approximation (NLLA), matched NLLA and O(\\alpha^{2}_{s})...

  3. ALPHA spokesperson Jeffrey Hangst gives a tour of the new ALPHA-2

    CERN Multimedia

    CERN Video Productions

    2012-01-01

    While many experiments are methodically planning for intense works over the long shutdown, there is one experiment that is already working at full steam: ALPHA-2. Its final components arrived last month and will completely replace the previous ALPHA set-up. Unlike its predecessor, this next generation experiment has been specifically designed to measure the properties of antimatter.

  4. Purification and characterization of an alpha-galactosidase from Aspergillus fumigatus

    Directory of Open Access Journals (Sweden)

    Sebastião Tavares de Rezende

    2005-03-01

    Full Text Available Aspergillus fumigatus secreted invertase (beta-fructofuranosidase and alpha-galactosidase enzymatic activities able to hydrolyzing raffinose oligosaccharides (RO. alpha-Galactosidase was induced by galactose, melibiose and raffinose, but galactose was the most efficient inducer. It was purified by gel filtration and two ion exchange chromatographies and showed Mw of 54.7 kDa. The purified enzyme showed maximal activity against p-nitrophenyl-alpha-D-galactopyranoside (pNPGal at pH 4.5-5.5 and 55 °C, and retained about 80% of the original activity after incubation for 90 minutes at 50ºC. The KM for pNPGal was 0.3 mM. Melibiose was hydrolyzed by the enzyme but raffinose was very poor substrate.O fungo termofílico Aspergillus fumigatus secreta as enzimas invertase (beta-frutofuranosidase e alfa-galactosidase (alfa-D-galactosídeo galactohi-drolase que estão envolvidas na hidrólise completa dos oligossacarídeos de rafinose. A enzima alfa-galactosidase foi produzida em meio de cultura do fungo Aspergillus fumigatus crescido por 36 h a 42 °C em meio mineral mínimo contendo os açúcares galactose, ou melibiose, ou rafinose como fontes de carbono. A enzima foi purificada por filtração em gel, seguida por duas cromatografias de troca iônica. A massa molecular da alfa-galactosidase determinada por SDS-PAGE foi de 54,7 kDa. A atividade máxima da enzima purificada, utilizando o substrato ro-nitrofenil-alfa-D-galactopiranosídeo (roNPGal foi na faixa de pH entre 4,5 e 5,5 e a 55 °C. A enzima manteve aproximadamente 80% de sua atividade original mesmo após pré-incubação por 90 minutos a 50 °C. O valor de KM para o substrato roNPGal foi 0,3 mM. A enzima foi capaz de hidrolisar melibiose, mas sua atividade foi muito reduzida na presença do substrato rafinose.

  5. Syntheses of alpha-tocopheryl glycosides by glucosidases.

    Science.gov (United States)

    Ponrasu, Thangavel; Charles, Rajachristu Einstein; Sivakumar, Ramaiah; Divakar, Soundar

    2008-08-01

    Enzymatic syntheses of water-soluble alpha-tocopheryl glycosides were carried out in di-isopropyl ether using amyloglucosidase from Rhizopus mold or beta-glucosidase isolated from sweet almond. Optimum conditions for the amyloglucosidase were: alpha-tocopherol 0.5 mmol, D-glucose 0.5 mmol, 400 activity unit (AU) amyloglucosidase, 0.2 mM pH 7 phosphate buffer and 72 h; and for the beta-glucosidase: alpha-tocopherol 0.5 mmol, D: -glucose 0.5 mmol, 110 AU beta-glucosidase, 0.1 mM pH 6 phosphate buffer and 72 h. Out of 11 carbohydrates employed, amyloglucosidase reacted only with D-glucose to give 50% of 6-O-(alpha-D-glucopyranosyl)alpha-tocopherol. However, the beta-glucosidase gave 6-O-(beta-D-glucopyranosyl)alpha-tocopherol, 6-O-(alpha-D-galactopyranosyl)alpha-tocopherol, 6-O-(beta-D-galactopyranosyl)alpha-tocopherol, 6-O-(alpha-D-mannopyranosyl)alpha-tocopherol and 6-O-(beta-D-mannopyranosyl)alpha-tocopherol in yields ranging from 10-25%. Water solubility of 6-O-(alpha-D-glucopyranosyl)alpha-tocopherol was 26 g/l at 25 degrees C. alpha-Tocopheryl glycosides showed antioxidant activities with IC(50) values from 0.5 to 1 mM and angiotensin-converting enzyme (ACE) inhibitory activity with IC(50) values from 1.3 to 2.6 mM. PMID:18368294

  6. H-alpha Observations of MKW10

    Science.gov (United States)

    Johnson, Harold; Coble, Kimberly A.; Koopmann, Rebecca A.; Durbala, Adriana; Undergraduate ALFALFA Team

    2016-01-01

    As part of the Undergraduate ALFALFA Team project looking at clusters and groups of galaxies to investigate the effects of environment on star formation, we analyzed H-alpha and R-band observations of the group MKW10 from the WIYN 0.9-m telescope with MOSAIC camera at Kitt Peak. We continuum-subtract the H-alpha images by scaling and subtracting the broadband R images. This process includes: determining the seeing of each image by calculating the FWHM values of several stars in the image; convolving all images to the worst seeing; stacking images for each filter; subtracting sky background; scaling the R image to H-alpha; and subtracting the scaled R from H-alpha. We then use the H-alpha-continuum-subtracted image to perform surface photometry of individual galaxies in MKW10. The data will be used to determine star formation rates and distributions of galaxies in this group environment and will be compared to results for galaxies in other UAT group and cluster environments. Analysis is ongoing.This work has been supported by NSF grant AST-1211005 and the Illinois Space Grant Consortium.

  7. Alpha methyldopa induced hepatotoxicity in pregnancy

    Directory of Open Access Journals (Sweden)

    Padmasri Ramalingappa

    2014-06-01

    Full Text Available We report a case of gestational hepatitis due to alpha-methyldopa and briefly review the literature on alpha-methyldopa-induced hepatotoxicity in pregnancy. A 32 year old woman, primigravida with 34 weeks of gestation with pre eclampsia, presented with symptoms of nausea, dark coloured urine and jaundice. She was on alpha methyldopa (Aldomet 250 mg thrice a day since the last five weeks. Laboratory investigations revealed raised bilirubin, serum aspartate transaminases and serum alanine transaminases. Platelets were normal. Peripheral smear did not show haemolysis. With the exclusion of viral, haemolytic and obstructive causes, drug induced jaundice was considered as a differential diagnosis. Alpha methyldopa was withdrawn and replaced with nifedipine for her pre eclampsia treatment. Her repeat bilirubin level done two weeks later showed a drop. She went into labour at 38 weeks and delivered vaginally. In postpartum follow up her liver tests returned to normal in two weeks, about six weeks after stopping methyldopa. Hepatotoxicity should be considered as one of the adverse drug reaction of alpha methyldopa. It is not possible at present to predict which patients will develop liver disease following the administration of this drug. An awareness of the possibility of methyldopa induced hepatotoxicity should be present in the clinician's mind and liver function tests should be done at regular intervals. The occasional occurrence of this harmful side effect is not a contraindication to the use of this antihypertensive agent. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 805-807

  8. Muestreo por conglomerados en encuestas poblacionales

    OpenAIRE

    Zapata-Ossa, Helmer de Jesús; Angela M Cubides-Munévar; María C. López; Pinzón-Gómez, Elisa M.; Filigrana-Villegas, Paola A.; Cassiani-Miranda, Carlos A.

    2012-01-01

    Objetivo Describir la técnica estadística del muestreo por conglomerados en encuestas de salud poblacionales. Métodos Se describen los aspectos más importantes de cada uno de los pasos metodológicos   haciendo énfasis en los fundamentos del Muestreo por Conglomerados. Éste se aplicó sobre una población  de aproximadamente 100 000 habitantes de la comuna 18 de Cali. La muestra abarcó 30 manzanas y se encuestaron 3 026 personas. La información se recolectó usando el Sistema de Información de ba...

  9. Tomate industrial con riego por cinta

    OpenAIRE

    Adán Fimbres-Fontes

    2004-01-01

    La región agrícola de Caborca cuenta con una superficie de 40 000 ha, las cuales se riegan con agua proveniente de aproximadamente 700 pozos. El abatimiento del manto acuífero es, en promedio, de 0.82 m año-1 y, en 25 años, ha sido de 20.50 m, medidos al nivel estático. El agua es uno de los factores más importantes en la producción de cualquier cultivo en la región. El objetivo del presente trabajo fue optimizar la cantidad de agua por aplicar al tomate industrial cultivado con riego por cin...

  10. Conservación por calor

    OpenAIRE

    Cobos García, Angel; Díaz Rubio, Olga

    2011-01-01

    Esta unidade didáctica denominada Conservación por calor forma parte da materia «Tecnoloxía do procesado de alimentos» que se impartirá no primeiro semestre do 2º curso do Grao en Nutrición Humana e Dietética. A materia estrutúrase en diferentes unidades didácticas, tratando cada unha delas as diferentes tecnoloxías de procesado dos alimentos, tanto de conservación coma de transformación. A presente unidade didáctica aborda a conservación dos alimentos por calor. Este método permite destruír ...

  11. Celulitis por cuerpo extraño

    Directory of Open Access Journals (Sweden)

    Miguel B. Carrasco Guzmán

    2016-01-01

    Full Text Available Las infecciones de la piel y el tejido celular subcutáneo surgen como un grupo importante de afecciones con una alta morbilidad en edades pediátricas, generalmente relacionada con traumatismo y cuerpos extraños. Se presenta el caso de una escolar femenina de 6 años de edad, con síntomas y signos clínicos que sugieren celulitis en el muslo derecho,  por su evolución tórpida se le realizó el estudio ultrasonográfico que confirmó el diagnóstico etiológico de una celulitis secundaria a un traumatismo, provocada por la introducción de un gran cuerpo extraño, que pasó inadvertido para a familia de la menor.

  12. Non-adiabatic dynamics in 10Be with the microscopic alpha+alpha+n+n model

    CERN Document Server

    Ito, M

    2006-01-01

    The alpha+6He low-energy reactions and the structural changes of 10Be in the microscopic alpha+alpha+n+n model are studied by the generalized two-center cluster model with the Kohn-Hulthen-Kato variation method. It is found that, in the inelastic scattering to the alpha+6He(2+) channel, characteristic enhancements are expected as the results of the parity-dependent non-adiabatic dynamics. In the positive parity state, the enhancement originates from the no-adiabatic eigenstate generated by the radial excitation of the relative motion between two alpha-cores. On the other hand, the enhancement in the negative parity state is induced by the Landau-Zener level-crossing. These non-adiabatic processes are discussed in connection to the formation of the inversion doublet in the compound system of 10Be.

  13. Alpha decay favoured isotopes of some superheavy nuclei: Spontaneous fission versus alpha decay

    CERN Document Server

    Kiren, O V; Bubbly, S G

    2013-01-01

    Spontaneous fission and alpha decay are the main decay modes for superheavy nuclei. The superheavy nuclei which have small alpha decay half-life compared to spontaneous fission half-life will survive fission and can be detected in the laboratory through alpha decay. We have studied the alpha decay half-life and spontaneous half-life of some superheavy elements in the atomic range Z = 100-130. Spontaneous fission half-lives of superheavy nuclei have been calculated using the phenomenological formula and the alpha decay half-lives using Viola-Seaborg-Sobiczewski formula (Sobiczewski et al. 1989), semi empirical relation of Brown (1992) and formula based on generalized liquid drop model proposed by Dasgupta-Schubert and Reyes (2007). The results are reported here.

  14. Measurements of $\\alpha_{s}$ with the DELPHI detector at LEP

    CERN Document Server

    Flagmeyer, U

    2000-01-01

    The data collected with DELPHI during the LEP1 period is used to perform a simultaneous fit to the strong coupling constant alpha /sub s/ in 2/sup nd/ order perturbation theory and to the renormalisation scale x/sub mu /. The results are compared to alpha /sub s/ fits in 2 /sup nd/ order perturbation theory with fixed scale x/sub mu / and to other theoretically motivated scale setting methods. To determine the energy dependence of alpha /sub s/, event shape distributions and their mean values are measured for square root (s)=48 GeV to 189 GeV. The strong coupling alpha /sub s/ is extracted in O( alpha /sub s //sup 2/). Next to leading log approximation (NLLA) and in a combined scheme using - evaluated with fragmentation model generators, and an analytical power ansatz. (16 refs).

  15. sobrevida de ratas intoxicadas por paraquat

    Directory of Open Access Journals (Sweden)

    Y. Aular

    2005-01-01

    Full Text Available La vitamina C (VC y la trimetazidina (TMZ como antioxidantes y la posible acción intiinflamatoria de esta última podrían ser de utilidad en la intoxicación por paraquat. Por tal razón se decidió evaluar el efecto de esta asociación en los niveles de VC, peso y sobrevida de ratas intoxicadas por paraquat, para ello se diseñó un estudio con 56 ratas divididas en 8 grupos: A (control negativo; B (control positivo, recibieron 11 mg/Kg. de paraquat IP; C (pre tratadas con 28.5mg/Kg. VC oral; D (tratadas con 28.5mg/Kg. VC post intoxicación; E (pre tratadas con 5mg/Kg. TMZ oral; F (tratadas con 5mg/Kg. TMZ post intoxicación; G (pre tratadas con VC- TMZ; H (tratadas con VC- TMZ post intoxicación. Se determinaron niveles de VC, cambios de peso y sobrevida en los grupos experimentales durante 31 días. Los resultados mostraron el día 24 de experimentación: disminución de los niveles de VC en el grupo E (p<0.05 y aumento en el grupo G (p< 0.001, sobrevida de 62.5% (grupo G, 50% (grupos E y H y 25% (grupos C y D. Se concluye que la asociación VC- TMZ aumentó la sobrevida de ratas intoxicadas por paraquat

  16. Intoxicación por drogas

    Directory of Open Access Journals (Sweden)

    I. Gainza

    2003-01-01

    Full Text Available El consumo de drogas ilegales en nuestro país ha experimentado un notable cambio en los últimos años, relegando a la heroína e incorporando la cocaína, los derivados anfetamínicos como el "éxtasis" (MDMA, el "éxtasis líquido" (GHB y, en menor medida, la ketamina. Se lleva a cabo una revisión de la intoxicación aguda por opiáceos y de su tratamiento en los servicios de urgencias, teniendo en cuenta el descenso progresivo de los casos que se presentan con el advenimiento de nuevas formas de administración, así como la presencia de nuevas drogas adictivas que han dado lugar a un desplazamiento en los hábitos de consumo. Se expone la intoxicación por cocaína haciendo referencia a la clínica, el diagnóstico y el tratamiento. Se realiza una revisión sobre el cannabis y sus derivados, la historia de su consumo y preparaciones utilizadas, los efectos que producen en los distintos sistemas del organismo y sus principales mecanismos de acción. Por último se comentan los efectos del LSD y de las setas alucinógenas.

  17. Intoxicación aguda por plaguicidas

    Directory of Open Access Journals (Sweden)

    Durán-Nah Jaime Jesús

    2000-01-01

    Full Text Available OBJETIVO: Describir la epidemiología de la intoxicación aguda por plaguicidas (IAP en el Hospital General O'Horán de Mérida, Yucatán, México. MATERIAL Y MÉTODOS: Se revisaron los expedientes de 33 pacientes superscript three 13 años, tratados en una unidad de cuidados intensivos (UCI, entre 1994 y 1998. Se recopilaron variables demográficas y clínicas relevantes, y se aplicó estadística descriptiva. RESULTADOS: En la población estudiada predominó el sexo masculino (82% del medio rural (70%, y la edad media fue de 34 ± 15.8 años. El intento de suicidio fue causa frecuente de IAP (79%, y en 33% de los casos la intoxicación se produjo por la utilización de organofosforados. La mortalidad fue de 12%. CONCLUSIONES: La IAP fue baja entre los sujetos del medio rural, por lo que los resultados de este estudio parecen no reflejar la realidad del problema. Es importante añadir que los plaguicidas son utilizados con relativa frecuencia para el intento de suicidio.

  18. Leibniz damnificado por el terremoto de Lisboa

    Directory of Open Access Journals (Sweden)

    Evaristo ÁLVAREZ MUÑOZ

    2009-11-01

    Full Text Available RESUMEN: En las páginas que siguen se argumenta que al filósofo alemán Gottfried Wilhelm Leibniz —fallecido en Hannover en 1716— o, al menos, a su obra Teodicea, cabría contarlos, echadas las cuentas de la manera que se verá, entre las víctimas del terremoto de Lisboa de 1755. Asimismo se subraya la persistencia del pensamiento de Leibniz en las respuestas dadas por los filósofos del siglo XVIII al trágico suceso. Se estudian las reacciones de Voltaire, de Rousseau y de Kant ante los estragos provocados por el seísmo y se concluye que las manifestaciones de los dos primeros ya habían sido previstas en Teodicea e, incluso, la vía científica pretendida por Kant había sido abierta en Protogaea.ABSTRACT: It is argued here that German philosopher Gottfried Wilhelm Leibniz, passed away in 1716, and, specially, that his work Teodicea, could be considered amongst the victims of the Lisbon earthquake of 1755. The persistence of the Leibniz’s thought in the answers given by the philosophers of the 18th Century to the tragic event is also emphasized. Voltaire and Rousseau’s reactions to the damage caused by the earthquake had been anticipated in Teodicea and the scientific way followed by Kant had been initiated in Protogaea.

  19. Por un humor ético

    Directory of Open Access Journals (Sweden)

    Victor Paramo Valero

    2016-04-01

    Full Text Available Ética del humor es una obra original, abundantemente documentada, de contenido científico y filosófico, que aborda un problema de gran importancia en los actuales estudios de éticas aplicadas. La ética del humor es una nueva ética aplicada que pretende comprender el fenómeno del humor a la luz de sus implicaciones éticas. Como señala el autor, Juan Carlos Siurana, reputado experto en el ámbito de la filosofía práctica, el interés por el humor es un interés por la ética. En la obra no presenta una nueva teoría filosófica del humor –las cuales se han venido sucediendo, al menos, desde los Diálogos de Platón–, sino una nueva teoría ética, que toma al humor como objeto principal de análisis. Por tanto, la finalidad es realizar una aportación dentro del ámbito de la ética. Para ello se nutre de distintos estudios psicológicos, biológicos, fisiológicos y neurológicos sobre el humor, así como de clásicas obras de filosofía que han abordado esta cuestión.

  20. Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System.

    Science.gov (United States)

    Gorasia, Dhana G; Veith, Paul D; Hanssen, Eric G; Glew, Michelle D; Sato, Keiko; Yukitake, Hideharu; Nakayama, Koji; Reynolds, Eric C

    2016-08-01

    The type IX secretion system (T9SS) has been recently discovered and is specific to Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilizes the T9SS to transport many proteins including the gingipain virulence factors across the outer membrane and attach them to the cell surface via a sortase-like mechanism. At least 11 proteins have been identified as components of the T9SS including PorK, PorL, PorM, PorN and PorP, however the precise roles of most of these proteins have not been elucidated and the structural organization of these components is unknown. In this study, we purified PorK and PorN complexes from P. gingivalis and using electron microscopy we have shown that PorN and the PorK lipoprotein interact to form a 50 nm diameter ring-shaped structure containing approximately 32-36 subunits of each protein. The formation of these rings was dependent on both PorK and PorN, but was independent of PorL, PorM and PorP. PorL and PorM were found to form a separate stable complex. PorK and PorN were protected from proteinase K cleavage when present in undisrupted cells, but were rapidly degraded when the cells were lysed, which together with bioinformatic analyses suggests that these proteins are exposed in the periplasm and anchored to the outer membrane via the PorK lipid. Chemical cross-linking and mass spectrometry analyses confirmed the interaction between PorK and PorN and further revealed that they interact with the PG0189 outer membrane protein. Furthermore, we established that PorN was required for the stable expression of PorK, PorL and PorM. Collectively, these results suggest that the ring-shaped PorK/N complex may form part of the secretion channel of the T9SS. This is the first report showing the structural organization of any T9SS component.

  1. Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System.

    Science.gov (United States)

    Gorasia, Dhana G; Veith, Paul D; Hanssen, Eric G; Glew, Michelle D; Sato, Keiko; Yukitake, Hideharu; Nakayama, Koji; Reynolds, Eric C

    2016-08-01

    The type IX secretion system (T9SS) has been recently discovered and is specific to Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilizes the T9SS to transport many proteins including the gingipain virulence factors across the outer membrane and attach them to the cell surface via a sortase-like mechanism. At least 11 proteins have been identified as components of the T9SS including PorK, PorL, PorM, PorN and PorP, however the precise roles of most of these proteins have not been elucidated and the structural organization of these components is unknown. In this study, we purified PorK and PorN complexes from P. gingivalis and using electron microscopy we have shown that PorN and the PorK lipoprotein interact to form a 50 nm diameter ring-shaped structure containing approximately 32-36 subunits of each protein. The formation of these rings was dependent on both PorK and PorN, but was independent of PorL, PorM and PorP. PorL and PorM were found to form a separate stable complex. PorK and PorN were protected from proteinase K cleavage when present in undisrupted cells, but were rapidly degraded when the cells were lysed, which together with bioinformatic analyses suggests that these proteins are exposed in the periplasm and anchored to the outer membrane via the PorK lipid. Chemical cross-linking and mass spectrometry analyses confirmed the interaction between PorK and PorN and further revealed that they interact with the PG0189 outer membrane protein. Furthermore, we established that PorN was required for the stable expression of PorK, PorL and PorM. Collectively, these results suggest that the ring-shaped PorK/N complex may form part of the secretion channel of the T9SS. This is the first report showing the structural organization of any T9SS component. PMID:27509186

  2. Alpha indirect conversion radioisotope power source

    Energy Technology Data Exchange (ETDEWEB)

    Sychov, Maxim [TRACE Photonics Inc., 1680 West Polk, Charleston, IL 61920 (United States)], E-mail: msychov@yahoo.com; Kavetsky, Alexandr; Yakubova, Galina; Walter, Gabriel; Yousaf, Shahid; Lin, Qian; Chan, Doris; Socarras, Heather; Bower, Kenneth [TRACE Photonics Inc., 1680 West Polk, Charleston, IL 61920 (United States)

    2008-02-15

    Advantages of radioisotope-powered electric generators include long service life, wide temperature range operation and high-energy density. We report development of a long-life generator based on indirect conversion of alpha decay energy. Prototyping used 300 mCi Pu-238 alpha emitter and AlGaAs photovoltaic cells designed for low light intensity conditions. The alpha emitter, phosphor screens, and voltaic arrays were assembled into a power source with the following characteristics: I{sub sc}=14 {mu}A; U{sub oc}=2.3 V; power output -21 {mu}W. Using this prototype we have powered an eight-digit electronic calculator and wrist watch.

  3. Coefficient alpha and interculture test selection.

    Science.gov (United States)

    Thurber, Steven; Kishi, Yasuhiro

    2014-04-01

    The internal consistency reliability of a measure can be a focal point in an evaluation of the potential adequacy of an instrument for adaptation to another cultural setting. Cronbach's alpha (α) coefficient is often used as the statistical index for such a determination. However, alpha presumes a tau-equivalent test and may constitute an inaccurate population estimate for multidimensional tests. These notions are expanded and examined with a Japanese version of a questionnaire on nursing attitudes toward suicidal patients, originally constructed in Sweden using the English language. The English measure was reported to have acceptable internal consistency (α) albeit the dimensionality of the questionnaire was not addressed. The Japanese scale was found to lack tau-equivalence. An alternative to alpha, "composite reliability," was computed and found to be below acceptable standards in magnitude and precision. Implications for research application of the Japanese instrument are discussed. PMID:22523134

  4. Lyman-alpha Absorption from Heliosheath Neutrals

    CERN Document Server

    Wood, B E; Linsky, J L; Malama, Y G; Wood, Brian E.; Izmodenov, Vladislav V.; Linsky, Jeffrey L.; Malama, Yury G.

    2006-01-01

    We assess what information HST observations of stellar Ly-alpha lines can provide on the heliosheath, the region of the heliosphere between the termination shock and heliopause. To search for evidence of heliosheath absorption, we conduct a systematic inspection of stellar Ly-alpha lines reconstructed after correcting for ISM absorption (and heliospheric/astrospheric absorption, if present). Most of the stellar lines are well centered on the stellar radial velocity, as expected, but the three lines of sight with the most downwind orientations relative to the ISM flow (Chi1 Ori, HD 28205, and HD 28568) have significantly blueshifted Ly-alpha lines. Since it is in downwind directions where heliosheath absorption should be strongest, the blueshifts are almost certainly caused by previously undetected heliosheath absorption. We make an initial comparison between the heliosheath absorption and the predictions of a pair of heliospheric models. A model with a complex multi-component treatment of plasma within the he...

  5. Review on alpha sub s at LEP

    CERN Document Server

    Wicke, D

    2000-01-01

    To measure the strong coupling alpha sub s from event shape observables two ingredients are necessary: a perturbative prediction containing the dependence of observables on alpha sub s and a description of the hadronisation process to match the perturbative prediction with the hadronic data. As perturbative prediction O(alpha sup 2 sub s), NLLA and combined calculations are available. Beside the well known Monte-Carlo based models also analytical predictions, so called power corrections, exist to describe the hadronisation. Advantages and disadvantages of the different resulting methods for determining the strong coupling and its energy dependence will be discussed, the newest DELPHI results will be presented, and an overview of the LEP results will be included.

  6. Relativistic effects in Lyman-alpha forest

    CERN Document Server

    Iršič, Vid; Viel, Matteo

    2015-01-01

    We present the calculation of the Lyman-alpha (Lyman-$\\alpha$) transmitted flux fluctuations with full relativistic corrections to the first order. Even though several studies exist on relativistic effects in galaxy clustering, this is the first study to extend the formalism to a different tracer of underlying matter at unique redshift range ($z = 2 - 5$). Furthermore, we show a comprehensive application of our calculations to the Quasar- Lyman-$\\alpha$ cross-correlation function. Our results indicate that the signal of relativistic effects can be as large as 30% at Baryonic Acoustic Oscillation (BAO) scale, which is much larger than anticipated and mainly due to the large differences in density bias factors of our tracers. We construct an observable, the anti-symmetric part of the cross- correlation function, that is dominated by the relativistic signal and offers a new way to measure the relativistic terms at relatively small scales. The analysis shows that relativistic effects are important when considerin...

  7. ALPHA MIS: Reference manual. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Lovin, J.K.; Haese, R.L.; Heatherly, R.D.; Hughes, S.E.; Ishee, J.S.; Pratt, S.M.; Smith, D.W.

    1992-02-01

    ALPHA is a powerful and versatile management information system (MIS) initiated and sponsored and by the Finance and Business Management Division of Oak Ridge National Laboratory, who maintain and develop it in concert with the Business Systems Division for its Information Center. A general-purpose MIS, ALPHA allows users to access System 1022 and System 1032 databases to obtain and manage information. From a personal computer or a data terminal, Energy Systems employees can use ALPHA to control their own report reprocessing. Using four general commands (Database, Select, Sort, and Report) they can (1) choose a mainframe database, (2) define subsets within it, (3) sequentially order a subset by one or more variables, and (4) generate a report with their own or a canned format.

  8. Imágenes en sísmica pasiva por migración interferométrica: aplicación para microsismicidad inducida por fracturamiento hidráulico

    OpenAIRE

    Arenas Mora, John Henry

    2013-01-01

    En este trabajo se intenta demostrar la aplicabilidad del concepto de migración interferométrica para la generación de imagen sísmica a partir de registros microsísmicos. El objetivo es indagar sobre el uso de estos registros para la síntesis de la reflectividad del medio. Se realizan dos simulaciones utilizando el código de modelamiento de ecuación de onda en diferencias finitas llamado FDELMODC. Estas se configuran con fuentes profundas que pretenden emular los eventos inducidos en un fract...

  9. Efecto antioxidante del extracto acuoso de propóleos sobre la hepatotoxicidad inducida por el octilfenol en ratas macho Antioxidant effect of aqueous extract of propolis on hepatotoxicity induced by octylphenol in male rats

    Directory of Open Access Journals (Sweden)

    Eman M Saleh

    2012-12-01

    Full Text Available El 4-terc-octilfenol (4-terc-OP es un alquilfenol que afecta a la salud humana mediante la estimulación de la producción de radicales libres. El extracto acuoso de propóleos es un producto natural rico en favonoides que tienen actividad antioxidante. Este estudio fue diseñado para investigar la capacidad del extracto de propóleos de reducir la hepatotoxicidad inducida por el 4-terc-OP en ratas macho. Los animales fueron asignados a 5 grupos y tratados durante 6 semanas. Grupo 1: control; grupo 2: 100 mg de 4-terc-OP/kg/día; grupo 3: 100 mg de extracto de propóleos/kg/día; grupo 4: 100 mg de 4-terc-OP/ kg/día más 100 mg de extracto de propóleos/kg/día, grupo 5: 100 mg de 4-terc-OP/kg/día durante 6 semanas, seguidos de 100 mg de extracto de propóleos/kg/día durante 6 semanas. El grupo 4-terc-OP mostró niveles signifcativamente elevados de AST, ALT, ALP, GGT, bilirrubina, creatinina, urea, lípidos totales, colesterol total, triglicéridos, LDL-C y MDA, con una disminución signi-fcativa de proteínas totales, albúmina, globulina, HDL-C, la capacidad antioxidante total, SOD, CAT y GST, en comparación con el grupo control. La administración de extracto de propóleos, ya sea solo o combinado con 4-terc-OP redujo la hepatotoxicidad inducida por 4-terc-OP. Los estudios de fragmentación del ADN apoyan el efecto deletéreo observado por el tratamiento con 4-terc-OP y el efecto protector del extracto de propóleos, sobre las proteínas y las enzimas celulares hepáticas. Los resultados histopatológicos revelaron la hepatotoxicidad por 4-terc-OP y efecto protector inducido por el extracto de propóleos. En conclusión, el extracto de propóleos podría reducir el daño hepático y los efectos celulares de toxicidad en las células del hígado inducidos por 4-terc-OP.4-tertiary-octylphenol (4-tert-OP is an alkylphenol that affects human health by stimulating free radical production. Aqueous propolis extract is a natural product rich in

  10. Parallel Genetic Algorithm for Alpha Spectra Fitting

    Science.gov (United States)

    García-Orellana, Carlos J.; Rubio-Montero, Pilar; González-Velasco, Horacio

    2005-01-01

    We present a performance study of alpha-particle spectra fitting using parallel Genetic Algorithm (GA). The method uses a two-step approach. In the first step we run parallel GA to find an initial solution for the second step, in which we use Levenberg-Marquardt (LM) method for a precise final fit. GA is a high resources-demanding method, so we use a Beowulf cluster for parallel simulation. The relationship between simulation time (and parallel efficiency) and processors number is studied using several alpha spectra, with the aim of obtaining a method to estimate the optimal processors number that must be used in a simulation.

  11. Alpha-beta discrimination in LENA

    International Nuclear Information System (INIS)

    Alpha emitting isotopes, mainly 210Po, provide a background for the detection of 7Be neutrinos in LENA (Low Energy Neutrino Astronomy). This background can be reduced by a pulse shape analysis, as alpha particles and electrons have a different typical pulse shape, caused by the different energy deposition per unit path length ((dE)/(dx)). Thus, the efficiency of this method was analyzed by a detailed Monte Carlo study. Several scintillators as well as the influence of the photomultiplier performance on the discrimination efficiency were investigated.

  12. Workshop on Precision Measurements of alphas

    CERN Document Server

    Bethke, S; Kluth, S; Schieck, J; Stewart, I W; Aoki, S; Beneke, M; Blumlein, J; Brambilla, N; Brodsky, S; Descotes-Genon, S; Erler, J; Forte, S; Gehrmann, T; Golterman, M; Hashimoto, S; Kronfeld, A; Kuhn, J; Lepage, P; Martin, A; Mateu, V; Menke, S; Nomura, Y; Pahl, C; Petriello, F; Pich, A; Rabbertz, K; Salam, G; Schulz, H; Sommer, R; Steinhauser, M; Webber, B; Yuan, CP; Zanderighi, G

    2011-01-01

    These are the proceedings of the "Workshop on Precision Measurements of alphas" held at the Max-Planck-Institute for Physics, Munich, February 9-11, 2011. The workshop explored in depth the determination of alphas(mZ) in the MS-bar scheme from the key categories where high precision measurements are currently being made, including DIS and global PDF fits, tau-decays, electroweak precision observables and Z-decays, event-shapes, and lattice QCD. These proceedings contain a short summary contribution from the speakers, as well as the lists of authors, conveners, participants, and talks.

  13. Alpha-nuclides in nuclear power plants

    International Nuclear Information System (INIS)

    The behaviour of alpha-nuclides in nuclear power plants is subject of the investigations presented. The source of alpha-nuclides is a contamination with fissile material (so called tramp uranium or tramp fuel) which deposits on fuel rod surfaces and leads to the build-up of transuranium nuclides. The determination of a defect situation with fuel release as well as the quantification of the fissile material contamination background is given for BWR and PWR plants. The quantification of the fuel release and the tramp uranium background can be calculated with different, measurable nuclides in BWR and PWR plants. (orig.)

  14. Re-visiting the Piper Alpha accident

    OpenAIRE

    Dykesteen, Mette Kahrs

    2013-01-01

    The main objective of this thesis has been to re-visit the Piper Alpha accident using the latest version of the FLACS simulation code. In 1988/89 simulations of the gas explosion in the C Module of Piper Alpha were performed by Jan Roar Bakke and Idar Storvik at Christian Michelsen Institute, in conjunction with the investigation after the accident. For these simulations the computer code FLACS was used [1, 2]. In this thesis, the same simulation cases have been looked into, and the results o...

  15. Task motivation influences alpha suppression following errors.

    Science.gov (United States)

    Compton, Rebecca J; Bissey, Bryn; Worby-Selim, Sharoda

    2014-07-01

    The goal of the present research is to examine the influence of motivation on a novel error-related neural marker, error-related alpha suppression (ERAS). Participants completed an attentionally demanding flanker task under conditions that emphasized either speed or accuracy or under conditions that manipulated the monetary value of errors. Conditions in which errors had greater motivational value produced greater ERAS, that is, greater alpha suppression following errors compared to correct trials. A second study found that a manipulation of task difficulty did not affect ERAS. Together, the results confirm that ERAS is both a robust phenomenon and one that is sensitive to motivational factors. PMID:24673621

  16. Dipole oscillation modes in $\\alpha$-clustering light nuclei

    CERN Document Server

    He, W B; Cao, X G; Cai, X Z; Zhang, G Q

    2016-01-01

    The alpha cluster states are discussed in an extended quantum molecular dynamics (EQMD) model frame. Different alpha cluster structures are studied in details, such as $^8$Be two-alpha cluster structure, $^{12}$C triangle structure, $^{12}$C chain structure, $^{16}$O chain structure, $^{16}$O kite structure, and $^{16}$O square structure. The properties like width of wave packets for different alpha clusters, momentum distribution, and the binding energy among alpha clusters are studied. It is also discussed how the $\\alpha$ cluster degree of freedom affects nuclear collective vibrations. The different $\\alpha$ cluster configurations in $^{12}$C and $^{16}$O have corresponding characteristic spectra of GDR and the coherence of different alpha clusters's dipole oscillation are described in details. The number and centroid energies of peaks in the GDR spectra can be reasonably explained by the geometrical and dynamical symmetries of $\\alpha$-clustering configurations. The GDR can be regarded as a very effective...

  17. Green Pea Galaxies Reveal Secrets of Ly$\\alpha$ Escape

    CERN Document Server

    Yang, Huan; Gronke, Max; Rhoads, James E; Jaskot, Anne; Zheng, Zhenya; Dijkstra, Mark

    2015-01-01

    Star-formation in galaxies generates a lot of Ly$\\alpha$ photons. Understanding the escape of Ly$\\alpha$ photons from galaxies is a key issue in studying high redshift galaxies and probing cosmic reionization with Ly$\\alpha$. To understand Ly$\\alpha$ escape, it is valuable to study analogs of high redshift Ly$\\alpha$ emitters in nearby universe. However, most nearby analogs have too small a Ly$\\alpha$ equivalent width and escape fraction compared to high redshift Ly$\\alpha$ emitters. One different group of nearby analogs are "Green Pea" galaxies, selected by their high equivalent width optical emission lines. Here we show that Green Pea galaxies have strong Ly$\\alpha$ emission lines and high Ly$\\alpha$ escape fraction (see also Henry et al. 2015), providing an opportunity to solve Ly$\\alpha$ escape problem. Green Peas have a Ly$\\alpha$ equivalent width distribution similar to high redshift Ly$\\alpha$ emitters. The Ly$\\alpha$ escape fraction correlates with many quantities of Ly$\\alpha$ profile, especially the...

  18. A practical alpha particle irradiator for studying internal alpha particle exposure.

    Science.gov (United States)

    Lee, Ki-Man; Lee, Ui-Seob; Kim, Eun-Hee

    2016-09-01

    An alpha particle irradiator has been built in the Radiation Bioengineering Laboratory at Seoul National University (SNU) to investigate the cellular responses to alpha emissions from radon and the progeny. This irradiator is designed to have the energy of alpha particles entering target cells similar to that of alpha emissions from the radon progeny Po-218 and Po-214 residing in the human respiratory tract. For the SNU alpha particle irradiator, an irradiation system is equipped with cell dishes of 4µm thick Mylar bottom and a special setup of cells on slide for gamma-H2AX assay. Dose calibration for the alpha particle irradiator was performed by dual approaches, detection and computer simulation, in consideration of the source-to-target distance (STD) and the size of a cell dish. The uniformity of dose among cells in a dish is achieved by keeping the STD and the size of cell dish in certain ranges. The performance of the SNU alpha particle irradiator has been proven to be reliable through the gamma-H2AX assay with the human lung epithelial cells irradiated. PMID:27475622

  19. A survey of the alpha-nucleon interaction

    International Nuclear Information System (INIS)

    A survey of the alpha-nucleon interaction is made. The experimental work on angular distributions of differential scattering cross-sections and polarizations in proton-alpha and neutron-alpha scattering is described. The phenomenological approach which includes the study of both local and non-local potentials reproducing the experimental alpha-nucleon scattering data, is discussed. Basic studies of the alpha-nucleon interaction attempting to build an interaction between an alpha particle and a nucleon from first principles are then described. A critical discussion of the results with some concluding remarks suggesting the direction for further investigation is made. (author)

  20. \\alpha-Discounting Multi-Criteria Decision Making (\\alpha-D MCDM)

    CERN Document Server

    Smarandache, Florentin

    2010-01-01

    In this paper we introduce a new method called \\alpha-Discounting Multi-Criteria Decision Making (\\alpha-D MCDM), which is an aletrnative and extension of Saaty's Analytical Hierarchy Process (AHP). It works for any set of preferences that can be transformed into a system of homogeneous linear equations. A degree of consistency (and implicitly a degree of inconsistency) of a decision-making problem are defined. \\alpha-D MCDM is then generalized to a set of preferences that can be transformed into a system of linear and/or non-linear equations and/or inequalities. Many consistent, weak inconsistent, and strong inconsistent examples are given.

  1. Synthesis of 16 alpha-/sub 3/H androgen and estrogen substrates for 16 alpha-hydroxylase

    Energy Technology Data Exchange (ETDEWEB)

    Cantineau, R.; Kremers, P.; De Graeve, J.; Cornelis, A.; Laszlo, P.; Gielen, J.E.; Lambotte, R.

    1981-02-01

    The synthesis of 16 alpha-/sup 3/H androgens and estrogens is described. 1-(/sup 3/H)-Acetic acid in the presence of zinc dust reacts with 16 alpha-bromo-17-ketosteroids to produce 16 alpha-/sup 3/H-17-ketosteroids. This chemical reaction was used to prepare 16 alpha-/sup 3/H-dehydroepiandrosterone (I) and 16 alpha-/sub 4/H-estrone acetate (XI) from 16 alpha-bromo-dehydroepiandrosterone (X) and from 16 alpha-bromo-estrone acetate (XII), respectively. Using appropriate microbiological techniques, it was possible to convert these radiolabelled substrates into 16 alpha-/sup 3/H-androstenedione (II) and 16 alpha-/sup 3/H-estradiol-17 beta (VII). 16 alpha-/sup 3/H-Estrone (VI) was obtained by the chemical hydrolysis of 16 alpha-/sup 3/H-estrone acetate. The label distribution as determined by microbiological 16 alpha-hydroxylations indicated a specific labelling of 77% for androgens and 65% for estrogens in the 16 alpha position. These substrates can be used for measuring the 16 alpha hydroxylase activity, an important step in the biosynthesis of estriol (VIII) and estetrol (IX).

  2. Cefaleia por uso excessivo de medicamentos

    Directory of Open Access Journals (Sweden)

    Ariane Maria Fonseca MIRANDA

    2015-01-01

    Full Text Available Uma variante da cefaleia crônica diária, a cefaleia por uso excessivo de medicamentos é uma manifestação clínica de frequência ≥ 15 dias por mês, durante 3 meses. Possui um diagnóstico deficiente e um tratamento dividido em etapas, sendo a desintoxicação, a etapa de fundamental importância. Este artigo apresenta uma revisão sobre o tema, contribuindo para o esclarecimento das principais manifestações clínicas, principais teorias envolvendo sua fisiopatologia e a terapêutica farmacológica empregada. A metodologia utilizada foi uma revisão de publicações europeias e americanas, no período de 2001 a 2013, nos idiomas português, inglês e espanhol. Todos os medicamentos utilizados no tratamento sintomático das cefaleias são capazes de cronificar uma cefaleia preexistente, desde que sejam utilizados excessivamente, de forma regular e continuada. A suspensão de tais agentes terapêuticos resultará em melhoria na maioria dos pacientes, porém pode ser necessária a introdução de uma terapia de suporte de transição e/ou terapia profilática. Os tratamentos nao farmacológicos, quando associados ao farmacológico, ampliam a possibilidade de resultados satisfatórios, evitando recaídas.

  3. Bacteremias por bacilos gram-negativos

    Directory of Open Access Journals (Sweden)

    Adrelírio J. R. Gonçalves

    1969-01-01

    Full Text Available São apresentados 31 casos de bacteremia por gram-negativos, assunto que vem merecendo muita atenção dos pesquisadores nos últimos anos. Os organismos etiológicos mais importantes que apareceram em igualdade de freqüência foram Escherichia coli e Klebsiella-Aerobacter, sendo responsáveis por 58% do total das infecções, seguidos por Pseudomonas. A porta de entrada mais freqüente foi o trato urinário em 61,3% dos casos. A infecção foi mais comum no sexo masculino e a faixa etária de 50 a 60 anos predominou. O uso prévio de antibióticos foi um fator predisponente muito importante, seguido pelo uso de esteróides e citostáticos. As principais doenças predisponentes foram diabetes mellitus e neoplasias malignas. Os principais fatores precipitantes foram a manipulação do aparelho urinário, com infecção prévia ou desencadeada, cirurgia do aparelho digestivo, uronatia obstrutiva e obstrução biliar. As principais manifestações clínicas foram a presença de febre, calafrios e hipotensão arterial. A complicação mais freqüente foi o choque bacteriano que incidiu em 58% dos casos, aproximadamente três vêzes aquela relatada na literatura. As outras foram a insuficiência renal aguda, superinfecção e infecção pulmonar metastática. Considerações terapêuticas gerais e esquemas de antibióticos são propostos para estes casos. A mortalidade da bacteremia simples foi de 30,7% e quando associada ao choque elevou-se para 72,2% . As infecções por Pseudomonas foram 100% fatais.

  4. Travesía por mares piratas

    OpenAIRE

    Herrera, Elixabete

    2015-01-01

    Se analiza el viaje del buque quimiquero Mar María por zonas de alto riesgo de piratería, basada en la experiencia de supervivientes a ataques piratas, y se hace un resumen de la regulación legal de la piratería. Se explicitan la valoración de riesgos, las medidas de protección y el plan de contingencia antipirata. La construcción de una ciudadela es otro de los temas que se tratan, así como la manera de identificar a piratas.

  5. Leibniz damnificado por el terremoto de Lisboa

    OpenAIRE

    Evaristo ÁLVAREZ MUÑOZ

    2005-01-01

    RESUMEN: En las páginas que siguen se argumenta que al filósofo alemán Gottfried Wilhelm Leibniz —fallecido en Hannover en 1716— o, al menos, a su obra Teodicea, cabría contarlos, echadas las cuentas de la manera que se verá, entre las víctimas del terremoto de Lisboa de 1755. Asimismo se subraya la persistencia del pensamiento de Leibniz en las respuestas dadas por los filósofos del siglo XVIII al trágico suceso. Se estudian las reacciones de Voltaire, de Rousseau y de Kant ante los estragos...

  6. Estrategias de crecimiento empresarial aplicadas por hipermercados

    OpenAIRE

    Miraidy Leal Morantes; Yilian Cefalá Chirinos

    2003-01-01

    El presente estudio tiene como objetivo caracterizar las estrategias de crecimiento empresarial, representadas por alianzas y adquisiciones, que han sido aplicadas en el sector de distribución de bienes de consumo masivo, específicamente en los hipermercados ubicados en Maracaibo, Estado Zulia, como manera de responder al entorno competitivo y cambiante en el cual se desenvuelven. La investigación se desarrolló a través de un estudio de carácter descriptivo; para la recolección ...

  7. Neumonía por Stenotrophomonas maltophilia

    OpenAIRE

    Verny Huertas-Franco; María Isabel Lacayo-Pallais

    2014-01-01

    La Stenotrophomonas maltophilia es un bacilo gram negativo ambiental emergente que ha venido posicionándose entre el grupo de microorganismos multirresistentes como causa de infección en diversos órganos en ambiente hospitalario y en la comunidad. Se reporta este caso de insuficiencia respiratoria con neumonía severa por S. maltophilia adquirida en la comunidad en una paciente inmunocompetente que tuvo una rápida respuesta a tratamiento con trimetoprim sulfametoxazol cuando se logró identific...

  8. Los Cuentos Por Proyectos De Trabajo Global.

    OpenAIRE

    Reinaldos, María Inmaculada

    2012-01-01

    La educación infantil es importante en los primeros años del niño, ya que un aprendizaje temprano es determinante para un buen desarrollo cognitivo, motor, psicológico, intelectual, emocional, social del individuo, y para la formación de las facultades intelectuales y el desarrollo de la personalidad. La L.O.E. (2006) aboga por una enseñanza globalizada, y que abarque todas las dimensiones del niño, para que de esta forma se consiga un aprendizaje significativo. Actualmente, se apuesta ...

  9. Gestión por competencias

    OpenAIRE

    Patiño Rubiano, Benjamín

    2006-01-01

    El desarrollo de este trabajo tiene como objetivo principal comparar los modelos de gestión por competencias implementados en otras organizaciones para retroalimentarlo en la organización Schneider Electric de Colombia S.A Agencia Antioquia. Para el desarrollo del tema lo primero que se hizo fue hacer un análisis teórico, del cual se presentará una síntesis. Las competencias son la capacidad de hacer algo bien y en determinadas condiciones, su objetivo es el aprovechamiento de las cualidades ...

  10. Regulación por precios tope

    Directory of Open Access Journals (Sweden)

    Gerardo Soto Carrillo

    2009-06-01

    Full Text Available El presente trabajo describe las principales características del mecanismo de regulación por precios tope, incluyendo su ubicación dentro de las posibilidades de acción regulatoria, las críticas que se han planteado al mismo, así como los mecanismos complementarios utilizados y los riesgos involucrados en su desarrollo.---This article describes the main characteristics of the price cap regime of price regulation, including its location among other regulatory possibilities, critics received, complementary mechanisms and risks involved in its development.

  11. Neumonía por Stenotrophomonas maltophilia

    Directory of Open Access Journals (Sweden)

    Verny Huertas-Franco

    2014-03-01

    Full Text Available La Stenotrophomonas maltophilia es un bacilo gram negativo ambiental emergente que ha venido posicionándose entre el grupo de microorganismos multirresistentes como causa de infección en diversos órganos en ambiente hospitalario y en la comunidad. Se reporta este caso de insuficiencia respiratoria con neumonía severa por S. maltophilia adquirida en la comunidad en una paciente inmunocompetente que tuvo una rápida respuesta a tratamiento con trimetoprim sulfametoxazol cuando se logró identificar la bacteria.

  12. Por qué necesitamos la competencia

    OpenAIRE

    Schnappauf, Werner

    2010-01-01

    "La gran aportación de la Economía Social de Mercado es que domestica al capitalismo y lo lleva por caminos ordenados de modo que pone la tendencia humana al beneficio al servicio del bien común, conciliando el beneficio individual y el del conjunto de lasociedad", afirmó Werner Schnappauf, Director General de la Confederación Federal de la Industria Alemana (BDI), con motivo del 43 Simposio de Innsbruck del Instituto de Investigación para la Constitución Económica y la Competencia (FIW), ...

  13. Alpha thalassaemia-mental retardation, X linked

    Directory of Open Access Journals (Sweden)

    Gibbons Richard

    2006-05-01

    Full Text Available Abstract X-linked alpha thalassaemia mental retardation (ATR-X syndrome in males is associated with profound developmental delay, facial dysmorphism, genital abnormalities and alpha thalassaemia. Female carriers are usually physically and intellectually normal. So far, 168 patients have been reported. Language is usually very limited. Seizures occur in about one third of the cases. While many patients are affectionate with their caregivers, some exhibit autistic-like behaviour. Patients present with facial hypotonia and a characteristic mouth. Genital abnormalities are observed in 80% of children and range from undescended testes to ambiguous genitalia. Alpha-thalassaemia is not always present. This syndrome is X-linked recessive and results from mutations in the ATRX gene. This gene encodes the widely expressed ATRX protein. ATRX mutations cause diverse changes in the pattern of DNA methylation at heterochromatic loci but it is not yet known whether this is responsible for the clinical phenotype. The diagnosis can be established by detection of alpha thalassaemia, identification of ATRX gene mutations, ATRX protein studies and X-inactivation studies. Genetic counselling can be offered to families. Management is multidisciplinary: young children must be carefully monitored for gastro-oesophageal reflux as it may cause death. A number of individuals with ATR-X are fit and well in their 30s and 40s.

  14. The Alpha Constant from Relativistic Groups

    CERN Document Server

    González-Martin, G R

    2000-01-01

    The value of the alpha constant, known to be equal to an algebraic expression in terms of pi and entire numbers related to certain group volumes, is derived from the relativistic structure group of a geometric unified theory, its subgroups and corresponding symmetric space quotients.

  15. Superparamagnetic relaxation in alpha-Fe particles

    DEFF Research Database (Denmark)

    Bødker, Franz; Mørup, Steen; Pedersen, Michael Stanley;

    1998-01-01

    The superparamagnetic relaxation time of carbon-supported alpha-Fe particles with an average size of 3.0 Mm has been studied over a large temperature range by the use of Mossbauer spectroscopy combined with AC and DC magnetization measurements. It is found that the relaxation time varies...

  16. Understanding a Widely Misunderstood Statistic: Cronbach's "Alpha"

    Science.gov (United States)

    Ritter, Nicola L.

    2010-01-01

    It is important to explore score reliability in virtually all studies, because tests are not reliable. The present paper explains the most frequently used reliability estimate, coefficient alpha, so that the coefficient's conceptual underpinnings will be understood. Researchers need to understand score reliability because of the possible impact…

  17. A method for extracting $cos\\alpha$

    CERN Document Server

    Grinstein, B; Rothstein, I Z; Grinstein, Benjamin; Nolte, Detlef R.; Rothstein, Ira Z.

    2000-01-01

    We show that it is possible to extract the weak mixing angle alpha via a measurement of the rate for B^+(-) -> \\pi^+(-) e^+e^-. The sensitivity to cos(alpha) results from the interference between the long and short distance contributions. The short distance contribution can be computed, using heavy quark symmetry, in terms of semi-leptonic form factors. More importantly, we show that, using Ward identities and a short distance operator product expansion, the long distance contribution can be calculated without recourse to light cone wave functions when the invariant mass of the lepton pair, q^2, is much larger than LQCDs. We find that for q^2 > 2 GeV^2 the branching fraction is approximately 1 * 10^{-8}|V_{td}/0.008|^2. The shape of the differential rate is very sensitive to the value of cos(alpha) at small values of q^2 with dGamma /dq^2 varying up to 50% in the interval -1< cos(alpha)< 1 at q^2= 2 GeV^2. The size of the variation depends upon the ratio V_{ub}/V_{td}.

  18. Interferon alpha association with neuromyelitis optica

    DEFF Research Database (Denmark)

    Asgari, Nasrin; Voss, Anne; Steenstrup, Troels;

    2013-01-01

    Interferon-alpha (IFN- α ) has immunoregulatory functions in autoimmune inflammatory diseases. The goal of this study was to determine occurrence and clinical consequences of IFN- α in neuromyelitis optica (NMO) patients. Thirty-six NMO and 41 multiple sclerosis (MS) patients from a population...

  19. Alpha particles diffusion due to charge changes

    Science.gov (United States)

    Clauser, C. F.; Farengo, R.

    2015-12-01

    Alpha particles diffusion due to charge changes in a magnetized plasma is studied. Analytical calculations and numerical simulations are employed to show that this process can be very important in the pedestal-edge-SOL regions. This is the first study that presents clear evidence of the importance of atomic processes on the diffusion of alpha particles. A simple 1D model that includes inelastic collisions with plasma species, "cold" neutrals, and partially ionized species was employed. The code, which follows the exact particle orbits and includes the effect of inelastic collisions via a Monte Carlo type random process, runs on a graphic processor unit (GPU). The analytical and numerical results show excellent agreement when a uniform background (plasma and cold species) is assumed. The simulations also show that the gradients in the density of the plasma and cold species, which are large and opposite in the edge region, produce an inward flux of alpha particles. Calculations of the alpha particles flux reaching the walls or divertor plates should include these processes.

  20. Syndecan-4 associates with alpha-actinin

    DEFF Research Database (Denmark)

    Greene, Daniel K; Tumova, Sarka; Couchman, John R;

    2002-01-01

    during the formation of focal adhesions. To date, a direct link between syndecan-4 and the cytoskeleton has remained elusive. We now demonstrate by Triton X-100 extraction immunoprecipitation and in vitro binding assays that the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta...

  1. E-PERM alpha surface monitor

    Energy Technology Data Exchange (ETDEWEB)

    Fricke, V.

    1999-12-16

    Innovative Technology Summary Reports are designed to provide potential users with the information they need to quickly determine if a technology would apply to a particular environmental management problem. They are also designed for readers who may recommend that a technology be considered by prospective users. Each report describes a technology, system, or process that has been developed and tested with funding from DOE's Office of Science and Technology (OST). The E-PERM{reg{underscore}sign} Alpha Surface Monitor is an integrating electret ion chamber innovative technology used to measure alpha radiation on surfaces of materials. The technology is best used on surfaces with low contamination levels such as areas with potential for free release, but can also be used in areas with higher levels of contamination. Measurement accuracy and production of the E-PERM {reg{underscore}sign} Alpha Surface Monitor compared favorably with the baseline technology. The innovative technology cost is approximately 28% higher than the baseline with an average unit cost per reading costing %6.04 vs. $4.36; however, the flexibility of the E-PERM{reg{underscore}sign} Alpha Surface Monitor may offer advantages in ALARA, reduction of operator error, waste minimization, and measurement accuracy.

  2. Production of alpha-amylase by yeast

    Energy Technology Data Exchange (ETDEWEB)

    Thomse, K.K.

    1987-01-01

    The enzyme alpha-amylase confers to an organism the enzymatic activity for the degradation of polyglucosides with alpha-1,4 glycosidic bonds such as starch and glycogen which are among the major storage compounds in plants and animals. Most alpha-amylases are single polypeptides of molecular weights around 50,000 dalton. They are generally found in the digestive tract of animals and in germinating seeds. Among the products released upon enzymatic degradation of polyglucosides maltose, a sugar that can be utilized as carbon source by yeast, is a major constituent. A cDNA segment complementary to mouse salivary amylase messenger RNA has been inserted into the yeast expression vector pMA56 behind the promoter of the gene encoding alcohol dehydrogenase I of yeast. Yeast transformants harboring plasmids with the normal orientation of the promoter and the mouse amylase cDNA gene produce amylase and release the enzyme in free form into the culture medium. Approximately 90% of the amylase activity is found in the medium. Yeast strains carrying MAL allele and transformed with a plasmid which directed the synthesis of mouse alpha-amylase were tested on plates containing starch and in batch fermentations using different high molecular weight sugars and oligosaccharides as carbon source. The results of these experiments will be discussed. (Refs. 21).

  3. Varying-Alpha Cosmologies with Potentials

    CERN Document Server

    Barrow, John D

    2008-01-01

    We generalize the Bekenstein-Sandvik-Barrow-Magueijo (BSBM) model for the variation of the fine structure 'constant', $\\alpha ,$ to include an exponential or inverse power-law self-potential for the scalar field $% \\phi $ which drives the time variation of $\\alpha $, and consider the dynamics of $\\phi$ in such models. We find solutions for the evolution of $\\phi $ or $\\alpha $ in matter-, radiation- and dark-energy-dominated cosmic eras. In general, the evolution of $\\phi $ is well determined solely by either the self-potential or the coupling to matter, depending on the model parameters. The results are general and applicable to other models where the evolution of a scalar field is governed by a matter coupling and a self-potential. We find that the existing astronomical data stringently constrains the possible evolution of $\\alpha $ between redshifts $z\\simeq 1-3.5$ and the present, and this leads to very strong limit on the allowed deviation of the potential from that of a pure cosmological constant.

  4. Cosmological attractors from alpha-scale supergravity

    NARCIS (Netherlands)

    Roest, Diederik; Scalisi, Marco

    2015-01-01

    The Planck value of the spectral index can be interpreted as n(s) = 1 - 2/N in terms of the number of e-foldings N. An appealing explanation for this phenomenological observation is provided by alpha-attractors: the inflationary predictions of these supergravity models are fully determined by the cu

  5. Alpha particles diffusion due to charge changes

    Energy Technology Data Exchange (ETDEWEB)

    Clauser, C. F., E-mail: cesar.clauser@ib.edu.ar; Farengo, R. [Centro Atómico Bariloche and Instituto Balseiro, Comisión Nacional de Energía Atómica and Universidad Nacional de Cuyo, Av. Bustillo 9500, 8400 Bariloche (Argentina)

    2015-12-15

    Alpha particles diffusion due to charge changes in a magnetized plasma is studied. Analytical calculations and numerical simulations are employed to show that this process can be very important in the pedestal-edge-SOL regions. This is the first study that presents clear evidence of the importance of atomic processes on the diffusion of alpha particles. A simple 1D model that includes inelastic collisions with plasma species, “cold” neutrals, and partially ionized species was employed. The code, which follows the exact particle orbits and includes the effect of inelastic collisions via a Monte Carlo type random process, runs on a graphic processor unit (GPU). The analytical and numerical results show excellent agreement when a uniform background (plasma and cold species) is assumed. The simulations also show that the gradients in the density of the plasma and cold species, which are large and opposite in the edge region, produce an inward flux of alpha particles. Calculations of the alpha particles flux reaching the walls or divertor plates should include these processes.

  6. Electronic key system using alpha detection

    International Nuclear Information System (INIS)

    We have developed the new electronic key system utilizes random pulse from alpha-particle detection with PIN photo diode. The random pulse by natural decay of alpha source is stable under the every outside environment like as temperature, pressure, an electromagnetic wave, and so on. The stable and un-predicted signals of the random pulses are the most suitable as a source of authentication signal for the electric key system. The program made of manufacture side forms the key code under current electronic key. Therefore, the manufacture must keep the code data secret for long time. The new electronic key always identify between key body and each key by the original pulse data from alpha particles. It is reduce the control cost of security remarkably. Moreover, back ground noise can be ignored in the circuit and it doesn't need to enlarge a total number of activity. The activity of the alpha source is about 10-100 Bq in one module. (author)

  7. Alpha particle effects on MHD ballooning

    International Nuclear Information System (INIS)

    During the period, as the first step towards the goal of detail understanding of the effects of alpha particle on MHD Ballooning Modes, a new numerical approach to investigate the stability of low-frequency fluctuations in high temperature tokamaks was developed by solving the gyrokinetic equations for the ion and electron directly as an initial value problem. The advantage of this approach is the inclusion of many important kinetic features of the problem without approximations and computationally more economical than particle-pushing simulation. The ion-temperature-gradient-mode was investigated to benchmark this new simulation technique. Previous results in literature were recovered. Both the adiabatic electron model and the full drift-kinetic electron model are studied. Numerical result shows that the full drift-kinetic electron model is more unstable. The development of subcycling technique to handle the fast electron bounce time is particularly significant to apply this new approach to the alpha particle problem since alpha particle bounce frequency is also significantly higher than the mode frequency. This new numerical technique will be the basis of future study of the microstability in high temperature tokamaks with alpha particles (or any energetic species). 15 refs., 13 figs

  8. Alpha particle diagnostics using impurity pellet injection

    International Nuclear Information System (INIS)

    We have proposed using impurity injection to measure the energy distribution of the fast confined alpha particles in a reacting plasma. The ablation cloud surrounding the injected pellet is thick enough that an equilibrium fraction Fo∞(E) of the incident alphas should be neutralized as they pass through the cloud. By observing neutrals created in the large spatial region of the cloud which is expected to be dominated by the helium-like ionization state, e.g., Li+ ions, we can determine the incident alpha distribution dnHe2+/dE from the measured energy distribution of neutral helium atoms. Initial experiments were performed on TEXT in which we compared pellet penetration with our impurity pellet ablation model, and measured the spatial distribution of various ionization states in carbon pellet clouds. Experiments have recently begun on TFTR with the goal of measuring the alpha particle energy distribution during D-T operation in 1993--94. A series of preliminary experiments are planned to test the diagnostic concept. The first experiments will observe neutrals from beam-injected deuterium ions and the high energy 3He tail produced during ICH minority heating on TFTR interacting with the cloud. We will also monitor by line radiation the charge state distributions in lithium, boron, and carbon clouds

  9. ALPHA THERMOLUMINESCENCE DOSIMETRY IN DATING OF POTTERY

    Institute of Scientific and Technical Information of China (English)

    王维达; 夏君定

    1994-01-01

    This article describes the measurement of internal alpha dose-rate in pottery using ultrathin CaSO4:Tm theromoluminescence dosimeter,Among the advantages of the technique are not only convenience,accuracy,lowcost,but also the beta dose-rate from pottery can be obtained at the same time.

  10. First stars in Damped Lyman Alpha systems

    NARCIS (Netherlands)

    Salvadori, Stefania; Ferrara, Andrea

    2011-01-01

    In order to characterize Damped Lyman Alpha systems (DLAs) potentially host- ing first stars, we present a novel approach to investigate DLAs in the context of Milky Way (MW) formation, along with their connection with the most metal-poor stars and local dwarf galaxies. The merger tree method previo

  11. Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues.

    Science.gov (United States)

    Eason, M G; Liggett, S B

    1993-07-01

    At present, molecular cloning and pharmacological studies have delineated three human alpha 2-adrenergic receptor (alpha 2AR) subtypes, alpha 2C10, alpha 2C4, and alpha 2C2. Assignment of the alpha 2AR subtypes to specific functions has been limited by an unclear definition of tissue alpha 2AR expression outside of the central nervous system. It has been suggested that alpha 2C4 expression is confined to the brain, that alpha 2C2 expression is only in the liver and kidney, and that there is nearly ubiquitous expression of alpha 2C10. However, this is based on studies of a limited number of rat tissues or on studies using non-species-specific approaches. Therefore, to define alpha 2C10, alpha 2C4, and alpha 2C2 tissue expression, we used reverse transcription of total RNA isolated from 20 human tissues, followed by amplification of alpha 2AR cDNA using the polymerase chain reaction. This technique provided two advantages: high sensitivity and, with the use of subtype-specific oligonucleotide primers and probes, differentiation between the alpha 2AR subtypes. The tissues studied were aorta, vena cava, heart (epicardium and endocardium), lung, skeletal muscle, liver, pancreas (head and tail), fat (perinephric and subcutaneous), kidney (cortex and medulla), prostate, stomach, ileum, jejunum, colon, adrenal gland, and spleen. We found that the majority of these tissues expressed alpha 2C10, with the exceptions being the head of the pancreas, subcutaneous fat, colon, and spleen. In marked distinction to other studies, however, we found a prolific expression of the alpha 2C4 and alpha 2C2 subtypes. Expression of alpha 2C4 was found in all tissues with the exception of liver, fat, stomach, and colon, and a virtually ubiquitous expression of alpha 2C2 was found, with the exception of epicardium. Of all tissues studied, only colon and subcutaneous fat expressed a single alpha 2AR subtype, which was alpha 2C2. Thus, the alpha 2AR subtypes do not have a confined expression but

  12. Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues.

    Science.gov (United States)

    Eason, M G; Liggett, S B

    1993-07-01

    At present, molecular cloning and pharmacological studies have delineated three human alpha 2-adrenergic receptor (alpha 2AR) subtypes, alpha 2C10, alpha 2C4, and alpha 2C2. Assignment of the alpha 2AR subtypes to specific functions has been limited by an unclear definition of tissue alpha 2AR expression outside of the central nervous system. It has been suggested that alpha 2C4 expression is confined to the brain, that alpha 2C2 expression is only in the liver and kidney, and that there is nearly ubiquitous expression of alpha 2C10. However, this is based on studies of a limited number of rat tissues or on studies using non-species-specific approaches. Therefore, to define alpha 2C10, alpha 2C4, and alpha 2C2 tissue expression, we used reverse transcription of total RNA isolated from 20 human tissues, followed by amplification of alpha 2AR cDNA using the polymerase chain reaction. This technique provided two advantages: high sensitivity and, with the use of subtype-specific oligonucleotide primers and probes, differentiation between the alpha 2AR subtypes. The tissues studied were aorta, vena cava, heart (epicardium and endocardium), lung, skeletal muscle, liver, pancreas (head and tail), fat (perinephric and subcutaneous), kidney (cortex and medulla), prostate, stomach, ileum, jejunum, colon, adrenal gland, and spleen. We found that the majority of these tissues expressed alpha 2C10, with the exceptions being the head of the pancreas, subcutaneous fat, colon, and spleen. In marked distinction to other studies, however, we found a prolific expression of the alpha 2C4 and alpha 2C2 subtypes. Expression of alpha 2C4 was found in all tissues with the exception of liver, fat, stomach, and colon, and a virtually ubiquitous expression of alpha 2C2 was found, with the exception of epicardium. Of all tissues studied, only colon and subcutaneous fat expressed a single alpha 2AR subtype, which was alpha 2C2. Thus, the alpha 2AR subtypes do not have a confined expression but

  13. Mulheres hospitalizadas por abortamento em uma Maternidade Escola na Cidade do Recife, Brasil Mujeres hospitalizadas por aborto en una maternidad escuela en la ciudad de Recife, Brasil Women hospitalized due to abortion in a maternity teaching hospital in Recife, Brazil

    Directory of Open Access Journals (Sweden)

    Karla da Silva Ramos

    2010-09-01

    Full Text Available Estudo de corte transversal, realizado com 160 mulheres no período de 2005-2006, com o objetivo de descrever as características sócio-demográficas e reprodutivas de mulheres hospitalizadas por abortamento e o conhecimento sobre métodos contraceptivos e de indução para o abortamento. Para determinação da associação entre a classificação do abortamento e as variáveis sócio-demográficas e reprodutivas, utilizou-se o teste qui-quadrado de Pearson, considerando-se o nível de significância de 5%. Observou-se uma frequência de 56,3% de abortamento possivelmente induzido. A maioria ocorreu antes das 12 semanas (55,7%. Em relação ao perfil das mulheres: 48,9% entre 20-29 anos, 72,0% com oito anos ou mais de estudo; 90,1% tinham companheiros; 52,0% tinham de 1-3 filhos, 100% conheciam a pílula e o preservativo, e 80,0% o misoprostol. O perfil sócio-demográfico e reprodutivo das mulheres hospitalizadas por abortamento no serviço não se alterou nos últimos anos. O método mais conhecido para indução do abortamento continua sendo o misoprostol.Estudio de corte transversal, realizado con 160 mujeres en el período 2005-2006 con el objetivo de describir las características socio-demográficas y reproductivas de mujeres hospitalizadas por aborto, el conocimiento sobre métodos anticonceptivos y de inducción del aborto. Para la determinación de la asociación entre la clasificación del aborto y las variables socio-demográficas y reproductivas se utilizó el test quincuadrado de Pearson, considerándose el nivel de significatividad de 5%. Se observó una frecuencia de 56,3% de abortos posiblemente inducidos. La mayoría ocurrió antes de las 12 semanas (55,7%. En relación al perfil de las mujeres: 48% entre 20 y 29 años, 72,0% con ocho años de estudios o más, 90,1% con compañeros, 52,0% tenían entre 1 y 3 hijos, 100% conocían la píldora y el condón y 80% el misoprostol. El perfil socio-demográfico y reproductivo de las

  14. The measurement of $\\alpha_s$ from event shapes with the DELPHI detector at the highest LEP energies

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alderweireld, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Ben-Haim, E; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Berntzon, L; Bertrand, D; Besançon, M; Besson, N; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Boonekamp, M; Booth, P S L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T J V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Brückman, P; Brunet, J M; Bugge, L; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Castro, N; Cavallo, F R; Chapkin, M M; Charpentier, P; Checchia, P; Chierici, R; Shlyapnikov, P; Chudoba, J; Chung, S U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M J; Crennell, D J; Cuevas-Maestro, J; D'Hondt, J; Dalmau, J; Da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; De Paula, L S; Di Ciaccio, Lucia; Di Simone, A; Doroba, K; Drees, J; Dris, M; Eigen, G; Ekelöf, T J C; Ellert, M; Elsing, M; Espirito-Santo, M C; Fanourakis, G K; Fassouliotis, D; Feindt, M; Fernández, J; Ferrer, A; Ferro, F; Flagmeyer, U; Föth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J A; Gandelman, M; García, C; Gavillet, P; Gazis, E N; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hallgren, A; Hamacher, K; Hamilton, K; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Herr, H; Hoffman, J; Holmgren, S O; Holt, P J; Houlden, M A; Hultqvist, K; Jackson, J N; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E K; Johansson, P D; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E C; Kernel, G; Kersevan, Borut P; Kerzel, U; Kiiskinen, A P; King, B T; Kjaer, N J; Kluit, P; Kokkinias, P; Kourkoumelis, C; Kuznetsov, O; Krumshtein, Z; Kucharczyk, M; Lamsa, J; Leder, G; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J H; López, J M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; McNulty, R; Meroni, C; Migliore, E; Mitaroff, W A; Mjörnmark, U; Moa, T; Moch, M; Mönig, K; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Müller, U; Münich, K; Mulders, M; Mundim, L M; Murray, W; Muryn, B; Myatt, Gerald; Myklebust, T; Nassiakou, M; Navarria, Francesco Luigi; Nawrocki, K; Nicolaidou, R; Nikolenko, M; Oblakowska-Mucha, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, Risto; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J P; Palka, H; Papadopoulou, T D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V F; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Pukhaeva, N; Pullia, Antonio; Rames, J; Ramler, L; Read, A; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P B; Richard, F; Rídky, J; Rivero, M; Rodríguez, D; Romero, A; Ronchese, P; Roudeau, Patrick; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovskii, A; Salmi, L; Salt, J; Savoy-Navarro, A; Schwickerath, U; Segar, A; Sekulin, R L; Siebel, M; Sissakian, A N; Smadja, G; Smirnova, O G; Sokolov, A; Sopczak, A; Sosnowski, R; Spassoff, Tz; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli de Fatis, T; Taffard, A C; Tegenfeldt, F; Timmermans, J; Tkatchev, L G; Tobin, M; Todorovova, S; Tomé, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Turluer, M L; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Uvarov, V; Valenti, G; van Dam, P; Van Eldik, J; Van Lysebetten, A; Van Remortel, N; Van Vulpen, I B; Vegni, G; Veloso, F; Venus, W A; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A J; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G; Winter, M; Witek, M; Yushchenko, O P; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zhuravlov, V; Zimin, N I; Zinchenko, A I; Zupan, M

    2004-01-01

    Hadronic event shape distributions are determined from data in e+e- collisions between 183 and 207 GeV. From these the strong coupling alpha_s is extracted in O(alpha_s^2), NLLA and matched O(alpha_s^2)+NLLA theory. Hadronisation corrections evaluated with fragmentation model generators as well as an analytical power ansatz are applied. Comparing these measurements to those obtained at and around M_Z allows a combined measurement of alpha_s from all DELPHI data and a test of the energy dependence of the strong coupling.

  15. Alpha decay of {sup 181}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Davids, C.N.; Henderson, D.J.; Hermann, R. [and others

    1995-08-01

    The {alpha}-decay energy of {sup 181}Pb was measured as 7211(10) keV and 7044(15). In the first study the isotope was produced in {sup 90}Zr bombardments of {sup 94}Mo and, after traversing a velocity filter, implanted in a position-sensitive Si detector; no half life for {sup 181}Pb was reported. In the second study the isotope was produced in {sup 40}Ca bombardments of {sup 144}Sm and transported to a position in front of a Si(Au) surface barrier detector with a fast He-gas-jet capillary system; an estimate of 50 ms was determined for the {sup 181}Pb half life. Recently we investigated {sup 181}Pb {alpha} decay at ATLAS as part of a survey experiment in which a l-pnA beam of 400-MeV {sup 92}Mo was used to irradiate targets of {sup 89}Y, {sup 90,92,94}Zr, and {sup 92}Mo to examine yields for one- and two-nucleon evaporation products from symmetric cold-fusion reactions. Recoiling nuclei of interest were passed through the Fragment Mass Analyzer and implanted in a double-sided silicon strip detector for {alpha}-particle assay. With the {sup 90}Zr target we observed a group at 7065(20) keV which was correlated with A = 181 recoils and had a half life of 45(20) ms. Our new results for {sup 181}Pb therefore agreed with those of the second study. There was no indication in the {sup 90}Zr + {sup 92}Mo data of the 7211(10)-keV {alpha} particles seen by Keller et al. The interested reader is referred to the 1993 atomic mass evaluation wherein the input {alpha}-decay energies and resultant masses of the light Pb isotopes (including {sup 181}Pb) are discussed.

  16. Sistema de climatización por suelo radiante coalimentado por energías renovables

    OpenAIRE

    Valdivieso Sarabia, Rafael Jesús; García Chamizo, Juan Manuel; Ferrández Pastor, Francisco Javier; Flórez-Revuelta, Francisco

    2010-01-01

    Se presenta el sistema de climatización basado en suelo radiante coalimentado por fuentes de energía renovables, que es capaz de proporcionar calor o frío. Se ha modelado una instalación genérica, que ha sido particularizada e integrada en una vivienda-laboratorio de unos 54m2. El sistema está compuesto por placas termo-solares, calentador eléctrico, bomba de calor aire-agua, acumuladores, circuito de suelo radiante y fancoil. El sistema de control está basado en un autómata que integra senso...

  17. Precision determination of alpha_s using an unbiased global NLO parton set

    CERN Document Server

    Lionetti, Simone; Bertone, Valerio; Cerutti, Francesco; Del Debbio, Luigi; Forte, Stefano; Guffanti, Alberto; Latorre, Jose I; Rojo, Juan; Ubiali, Maria

    2011-01-01

    We determine the strong coupling alpha_s from a next-to-leading order analysis of processes used for the NNPDF2.1 parton determination, which includes data from neutral and charged current deep-inelastic scattering, Drell-Yan and inclusive jet production. We find alpha_s(M_Z)=0.1191+-0.0006 (exp), where the uncertainty includes all statistical and systematic experimental uncertainties, but not purely theoretical uncertainties. We study the dependence of the results on the dataset, by providing further determinations based respectively on deep-inelastic data only, and on HERA data only. The deep-inelastic fit gives the consistent result alpha_s(M_Z)=0.1177+-0.0009(exp), but the result of the HERA-only fit is only marginally consistent. We provide evidence that individual data subsets can have runaway directions due to poorly determined PDFs, thus suggesting that a global dataset is necessary for a reliable determination.

  18. Degradation of the potato glycoalkaloids--alpha-solanine and alpha-chaconine in groundwater.

    Science.gov (United States)

    Jensen, Pia H; Jacobsen, Ole S; Henriksen, Trine; Strobel, Bjarne W; Hansen, Hans Christian B

    2009-06-01

    The potato glycoalkaloids alpha-chaconine and alpha-solanine are produced in high amounts in potato plants from where release to soil takes place. Degradation of the compounds in groundwater was investigated, as their fate in the terrestrial environment is unknown. Abiotic and microbial degradation were followed in groundwater sampled from below a potato field and spiked with the glycoalkaloids (115 nmol/l). Degradation was primarily microbial and the glycoalkaloids were degraded within 21-42 days. The metabolites beta(1)-solanine, gamma-solanine, and solanidine were formed from alpha-solanine, while beta-chaconine, gamma-chaconine and solanidine were detected from alpha-chaconine. Thus, indigenous groundwater microorganisms are capable of degrading the glycoalkaloids.

  19. Measurement of total alpha activity in water; Messung der Gesamt-Alpha-Aktivitaet in Wasser

    Energy Technology Data Exchange (ETDEWEB)

    Eikenberg, Jost [Paul Scherrer Institut (PSI), Villigen (Switzerland). Abt. fuer Strahlenschutz und Sicherheit; Florschuetz, Bernd [Hessisches Landesamt fuer Umwelt und Geologie, Kassel (Germany). Dezernat 15 - Strahlenschutz; Salvamoser, Josef [Institut fuer Angewandte Isotopen-, Gas- und Umweltuntersuchungen, Woerthsee (Germany); Steinkopff, Thomas [Deutscher Wetterdienst, Offenbach am Main (Germany); Wilhelm, Christoph [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Sicherheitsmanagement - Analytische Labore; Wisser, Sascha [FCI, Mainz (Germany)

    2014-04-01

    The article describes the measurement of the total alpha activity in an (evaporated) liquid sample, and the various sample preparation methods for measurements with proportional counters or LSC. (orig.)

  20. Dynamical Screening Effect on $\\alpha$-$\\alpha$ Resonant Scattering and Thermal Nuclear Scattering Rate

    CERN Document Server

    Yao, Xiaojun; Müller, Berndt

    2016-01-01

    We study the dynamical screening effect in the QED plasma on the $\\alpha$-$\\alpha$ scattering at the $^8$Be resonance. Dynamical screening leads to an imaginary part of the potential which results in a thermal width for the resonance and dominates over the previously considered static screening effect. As a result, both the resonance energy and width increase with the plasma temperature. Furthermore, dynamical screening can have a huge impact on the $\\alpha$-$\\alpha$ thermal nuclear scattering rate. For example, when the temperature is around $10$ keV, the rate is suppressed by a factor of about $900$. We expect similar thermal suppressions of nuclear reaction rates to occur in nuclear reactions dominated by an above threshold resonance with a thermal energy. Dynamical screening effects on nuclear reactions can be relevant to cosmology and astrophysics.

  1. Development of thermal conditioning technology for Alpha-containment wastes: Alpha-contaminated waste incineration technology

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joon Hyung; Kim, Jeong Guk; Yang, Hee Chul; Choi, Byung Seon; Jeong, Myeong Soo

    1999-03-01

    As the first step of a 3-year project named 'development of alpha-contaminated waste incineration technology', the basic information and data were reviewed, while focusing on establishment of R and D direction to develop the final goal, self-supporting treatment of {alpha}- wastes that would be generated from domestic nuclear industries. The status on {alpha} waste incineration technology of advanced states was reviewed. A conceptual design for {alpha} waste incineration process was suggested. Besides, removal characteristics of volatile metals and radionuclides in a low-temperature dry off-gas system were investigated. Radiation dose assessments and some modification for the Demonstration-scale Incineration Plant (DSIP) at Korea Atomic Energy Research Institute (KAERI) were also done.

  2. Constraints on the Preferred-Frame {\\alpha}1, {\\alpha}2 parameters from Solar System planetary precessions

    CERN Document Server

    Iorio, Lorenzo

    2014-01-01

    Analytical expressions for the orbital precessions affecting the relative motion of the components of a local binary system induced by Lorentz-violating Preferred Frame Effects (PFE) are explicitly computed in terms of the PPN parameters {\\alpha}1, {\\alpha}2. A linear combination of the supplementary perihelion precessions of all the inner planets of the Solar System, able to remove the a-priori bias of unmodelled/mismodelled standard effects such as the general relativistic Lense-Thirring precessions and the classical rates due to the Sun's oblateness J2, allows to infer {\\alpha}1 <= 10^-6, {\\alpha}2 <= 10^-5. Such bounds should be improved in the near future after processing the data that are being collected by the MESSENGER spacecraft, currently orbiting Mercury. Further improvements may come in the mid-future from the approved BepiColombo mission to Mercury (Abridged).

  3. Nodulose por Metotrexato Methotrexate Induced Nodulosis

    Directory of Open Access Journals (Sweden)

    Fernanda Guidolin

    2005-08-01

    Full Text Available A nodulose por metotrexato (MTX é um dos efeitos colaterais pouco conhecidos do uso desse medicamento em doses baixas. Embora classicamente descrita em casos de artrite reumatóide, tem aparecido, também, em outras doenças reumáticas. Descreve-se aqui um caso de nodulose por MTX em uma paciente com artrite reumatóide soropositiva, que utilizava esse medicamento há um ano, com bom controle do processo articular. Segue-se uma breve revisão sobre o assunto.Methotrexate-induced nodulosis is a rare side effect of this drug when it is used in low doses. Although classically described in rheumatoid arthritis patients, it may also appear in other rheumatic disorders. We describe a seropositive rheumatoid arthritis patient who developed methotrexate-induced nodulosis after using this drug for a year, with good control of articular symptoms. This case presentation is followed by a brief revision on the subject.

  4. Choque séptico por ehrliquiosis

    Directory of Open Access Journals (Sweden)

    Viviana Hernández-de Mezerville

    2007-04-01

    Full Text Available La ehrliquiosis humana es una infección zoonótica transmitida por "garrapatas duras" causada por Anaplasma sp y Ehrlichia sp. Puede presentarse como un cuadro pseudogripal con fiebre, malestar general, mialgias y cefalea o hasta un choque séptico con falla multiorgánica y muerte. La mitad de los pacientes requieren atención hospitalaria en algún momento y se reporta una mortalidad de hasta el 5% secundaria a enfermedades oportunistas o a hemorragias. El diagnóstico se puede sospechar visualizando las mórulas intracitoplasmáticas en las células afectadas en frotis de sangre periférica, y se confirma con serología, con cultivos o con detección molecular. El tratamiento de elección es la doxiciclina con buena respuesta clínica. Se reporta un caso probable de ehrliquiosis humana asociado a choque séptico y falla multiorgánica tratado exitosamente en el Hospital Dr. Rafael Angel Calderón Guardia.

  5. Luchas por el control territorial en Colombia

    Directory of Open Access Journals (Sweden)

    Darío I. Restrepo

    2002-01-01

    Full Text Available La tesis central del artículo es que la concurrencia entre los impactos de la globalización, el proceso de descentralización y la crisis política debilitan gravemente el Estado-Nación, y particularmente tienden a romperse las bases mismas del centralismo polÌtico, administrativo y económico. Por otra parte, se exacerban las luchas locales por la apropiación de las riquezas materiales y el control de las instituciones. De esta manera, se acrecienta el poder de negociación política de las fuerzas locales frente al gobierno central, tanto respecto de las funciones descentralizadas como de aquellas que mantiene el Estado de manera centralizada. Neoliberales, reformadores políticos, clases políticas territoriales, nuevos movimientos sociales, narcotraficantes, guerrilleros y paramilitares se disputan abiertamente el poder local. Todos tienen una estrategia, o al menos un conjunto de intereses y prácticas respecto del proceso de descentralización, el cual en última instancia no puede ser entendido sino como el resultado de la complejidad de fuerzas que intervienen en él.

  6. Interaction of alphaVbeta3 and alphaVbeta6 integrins with human parechovirus 1.

    Science.gov (United States)

    Seitsonen, Jani; Susi, Petri; Heikkilä, Outi; Sinkovits, Robert S; Laurinmäki, Pasi; Hyypiä, Timo; Butcher, Sarah J

    2010-09-01

    Human parechovirus (HPEV) infections are very common in early childhood and can be severe in neonates. It has been shown that integrins are important for cellular infectivity of HPEV1 through experiments using peptide blocking assays and function-blocking antibodies to alpha(V) integrins. The interaction of HPEV1 with alpha(V) integrins is presumably mediated by a C-terminal RGD motif in the capsid protein VP1. We characterized the binding of integrins alpha(V)beta(3) and alpha(V)beta(6) to HPEV1 by biochemical and structural studies. We showed that although HPEV1 bound efficiently to immobilized integrins, alpha(V)beta(6) bound more efficiently than alpha(V)beta(3) to immobilized HPEV1. Moreover, soluble alpha(V)beta(6), but not alpha(V)beta(3), blocked HPEV1 cellular infectivity, indicating that it is a high-affinity receptor for HPEV1. We also showed that HPEV1 binding to integrins in vitro could be partially blocked by RGD peptides. Using electron cryo-microscopy and image reconstruction, we showed that HPEV1 has the typical T=1 (pseudo T=3) organization of a picornavirus. Complexes of HPEV1 and integrins indicated that both integrin footprints reside between the 5-fold and 3-fold symmetry axes. This result does not match the RGD position predicted from the coxsackievirus A9 X-ray structure but is consistent with the predicted location of this motif in the shorter C terminus found in HPEV1. This first structural characterization of a parechovirus indicates that the differences in receptor binding are due to the amino acid differences in the integrins rather than to significantly different viral footprints.

  7. Perturbative expansion of tau hadronic spectral function moments and alpha_s extractions

    OpenAIRE

    Beneke, Martin; Boito, Diogo; Jamin, Matthias

    2012-01-01

    Various moments of the hadronic spectral functions have been employed in the determination of the strong coupling alpha_s from tau decays. In this work we study the behaviour of their perturbative series under different assumptions for the large-order behaviour of the Adler function, extending previous work on the tau hadronic width. We find that the moments can be divided into a small number of classes, whose characteristics depend only on generic features of the moment weight function and A...

  8. Estimation of Time-Varying Autoregressive Symmetric Alpha Stable

    Data.gov (United States)

    National Aeronautics and Space Administration — In the last decade alpha-stable distributions have become a standard model for impulsive data. Especially the linear symmetric alpha-stable processes have found...

  9. Plasma Ubiquinone, Alpha-Tocopherol and Cholesterol in Man

    DEFF Research Database (Denmark)

    Karlsson, Jan; Diamant, Bertil; Edlund, Per Olof;

    1992-01-01

    Farmakologi, Coenzyme Q10, free cholesterol, vitamin E, antioxidants, Alpha-Tocopherol, vitamin Q, plasma, LDL-particle......Farmakologi, Coenzyme Q10, free cholesterol, vitamin E, antioxidants, Alpha-Tocopherol, vitamin Q, plasma, LDL-particle...

  10. Synthesis of 15 alpha-hydroxyestrogen 15-N-acetylglucosaminides.

    Science.gov (United States)

    Suzuki, E; Namba, S; Kurihara, H; Goto, J; Matsuki, Y; Nambara, T

    1995-03-01

    The synthesis of 15-N-acetylglucosaminides of 15 alpha-hydroxyesterone, 15 alpha-hydroxyestradiol, and 15 alpha-hydroxyestriol (estetrol) is described. The latter two were prepared by condensation of 2-acetamido-1 alpha-chloro-1,2-dideoxy-3,4,6-trio-O-acetyl-D-glucopyranose with appropriately protected 15 alpha-hydroxyestrogens by the Koenigs-Knorr reaction employing cadmium carbonate as a catalyst. Subsequent removal of protecting groups with methanolic potassium hydroxide provided the desired conjugates. 15 alpha-Hydroxyestrone 15-N-acetylglucosaminide was synthesized from the corresponding 15 alpha-hydroxyestradiol derivative by Jones oxidation followed by brief alkaline hydrolysis. These conjugates underwent enzymatic hydrolysis with beta-N-acetylglucosaminidase from Jack beans to produce 15 alpha-hydroxyestrogens. PMID:7792832

  11. Extended Ly$\\alpha$ emission around quasars with eclipsing damped Ly$\\alpha$ systems

    CERN Document Server

    Fathivavsari, Hassan; Noterdaeme, Pasquier; Pâris, Isabelle; Finley, Hayley; López, Sebastian; Srianand, Raghunathan

    2016-01-01

    We present spectroscopic observations of six high redshift ($z_{\\rm em}$ $>$ 2) quasars, which have been selected for their Lyman $\\alpha$ (Ly$\\alpha$) emission region being only partially covered by a strong proximate ($z_{\\rm abs}$ $\\sim$ $z_{\\rm em}$) coronagraphic damped Ly$\\alpha$ system (DLA). We detected spatially extended Ly$\\alpha$ emission envelopes surrounding these six quasars, with projected spatial extent in the range 26 $\\le$ $d_{\\rm Ly\\alpha}$ $\\le$ 51 kpc. No correlation is found between the quasar ionizing luminosity and the Ly$\\alpha$ luminosity of their extended envelopes. This could be related to the limited covering factor of the extended gas and/or due to the AGN being obscured in other directions than towards the observer. Indeed, we find a strong correlation between the luminosity of the envelope and its spatial extent, which suggests that the envelopes are probably ionized by the AGN. The metallicity of the coronagraphic DLAs is low and varies in the range $-$1.75 $<$ [Si/H] $<...

  12. Suicidio por arma de fuego Suicide by firearm

    OpenAIRE

    M. Soriano Maldonado; P. Martínez-García

    2005-01-01

    El mecanismo elegido para cometer el suicidio depende de numerosos factores personales y sociales. En este número presentamos una imagen del tipo de suicidio más mediático, aunque no por ello el más frecuente en nuestro medio. La variabilidad en la forma de los orificios de entrada y salida por arma de fuego depende de la distancia, tipo de arma y región anatómica por lo que puede presentar una morfología muy variada. Es por ello que, aunque ya se han publicado varias imágenes de suicidio por...

  13. Silicon vertex detector upgrade in the ALPHA experiment

    CERN Document Server

    Amole, C; Ashkezari, M.D; Baquero-Ruiz, M; Bertsche, W; Burrows, C; Butler, E; Capra, A; Cesar, C.L; Chapman, S; Charlton, M; Deller, A; Eriksson, S; Fajans, J; Friesen, T; Fujiwara, M.C; Gill, D.R; Gutierrez, A; Hangst, J.S; Hardy, W.N; Hayden, M.E; Humphries, A.J; Isaac, C.A; Jonsell, S; Kurchaninov, L; Little, A; Madsen, N; McKenna, J.T.K; Menary, S; Napoli, S.C; Nolan, P; Olchanski, K; Olin, A; Povilus, A; Pusa, P; Rasmussen, C.Ø; Robicheaux, F; Sacramento, R.L; Sampson, J.A; Sarid, E; Seddon, D; Silveira, D.M; So, C; Stracka, S; Tharp, T; Thompson, R.I; Thornhill, J; Tooley, M.P; Van Der Werf, D.P; Wells, D

    2013-01-01

    The Silicon Vertex Detector (SVD) is the main diagnostic tool in the ALPHA-experiment. It provides precise spatial and timing information of antiproton (antihydrogen) annihilation events (vertices), and most importantly, the SVD is capable of directly identifying and analysing single annihilation events, thereby forming the basis of ALPHA ' s analysis. This paper describes the ALPHA SVD and its upgrade, installed in the ALPHA ' s new neutral atom trap.

  14. Expression of alpha-amylase in Bacillus licheniformis.

    OpenAIRE

    Rothstein, D. M.; Devlin, P E; Cate, R. L.

    1986-01-01

    In Bacillus licheniformis, alpha-amylase production varied more than 100-fold depending on the presence or absence of a catabolite-repressing carbon source in the growth medium. alpha-Amylase was produced during the growth phase and not at the onset of the stationary phase. Induction of alpha-amylase correlated with synthesis of mRNA initiating at the promoter of the alpha-amylase gene.

  15. A Meta-analysis of Cronbach's Coefficient Alpha.

    OpenAIRE

    Robert A. Peterson

    1994-01-01

    Despite some limitations, Cronbach's coefficient alpha remains the most widely used measure of scale reliability. The purpose of this article was to empirically document the magnitudes of alpha coefficients obtained in behavioral research, compare these obtained values with guidelines and recommendations set forth by individuals such as Nunnally (1967, 1978), and provide insights into research design characteristics that may influence the size of coefficient alpha. Average reported alpha coef...

  16. Covariation of spectral and nonlinear EEG measures with alpha biofeedback.

    NARCIS (Netherlands)

    Fell, J.; Elfadil, H.; Klaver, P.; Roschke, J.; Elger, C.E.; Fernandez, G.S.E.

    2002-01-01

    This study investigated how different spectral and nonlinear EEG measures covaried with alpha power during auditory alpha biofeedback training, performed by 13 healthy subjects. We found a significant positive correlation of alpha power with the largest Lyapunov-exponent, pointing to an increased dy

  17. Gravitational lensing by damped Ly-alpha absorbers

    NARCIS (Netherlands)

    Smette, A; Claeskens, JF; Surdej, J

    1997-01-01

    Assuming that (i) damped Ly-alpha absorbers (DLAs) arise in present-day-like spiral galaxies which are immersed in isothermal dark matter halos, (ii) that these galaxies obey the Tully-Fisher sigma/sigma* = (L/L*)(1/alpha TF) and the Holmberg R-L/R* = (L/L*)(alpha H) relations, and (iii) that they f

  18. alpha-Thalassemia mutation analyses in Mazandaran province, North Iran.

    Science.gov (United States)

    Tamaddoni, Ahmad; Hadavi, Valeh; Nejad, Nima Hafezi; Khosh-Ain, Atefeh; Siami, Rita; Aghai-Meibodi, Jalil; Almadani, Navid; Oberkanins, Christian; Law, Hai-Yang; Najmabadi, Hossein

    2009-01-01

    Two hundred and fifty-five patients from Mazandaran Province, Iran, all presenting with hypochromic and microcytic anemia, were selected for alpha-thalassemia (alpha-thal) mutation screening. We detected a total of 274 alpha-globin mutations in 227 (89%) of these patients. Among the 21 different alpha-globin alleles found, the -alpha(3.7) (44.9%), polyadenylation signal 2 (poly A2) (AATAAA>AATGAA) (18.2%), -alpha(4.2) (9.1%), alpha(IVS-I(-5 nt)) (6.5%), - -(MED) (4.3%), and alpha(codon 19 (-G)) (4%) were the most frequent. The other 15 mutations included variants that had not yet been observed in Iran, such as Hb Bleuland [alpha108(G15)ThrAsn, ACC>AAC (alpha2)], as well as a novel mutation on the alpha2 gene, also not described to date [3 ' untranslated region (3 'UTR) nucleotide (nt) 46 (C>A)]. These comprehensive new data are useful for establishing a screening strategy for the effective control of alpha-thal in Mazandaran Province. PMID:19373587

  19. Propriedades do Polestireno Modificado por Nanomateriais

    OpenAIRE

    Oliveira, Pedro Xavier Valente de

    2011-01-01

    A incorporação de nanocargas metálicas em matrizes poliméricas, transformando-as em nanocompósitos, constitui um desafio para a investigação em engenharia, no sentido de se dispor de materiais com melhor desempenho físico/mecânico em serviço. No presente estudo foi efectuada a caracterização de nanocompósitos de matriz polimérica reforçada, primeiro por uma carga metálica nanocristalina e posteriormente com adição de nanotubos. A matriz era poliestireno e os reforços nanocristalinos de aç...

  20. Hiperparatiroidismo primario por adenoma paratiroideo mediastinal

    OpenAIRE

    Jeffry Solís-Torres; Esteban Mora-Segura

    2015-01-01

    El hiperparatiroidismo primario cursa con un aumento de la secreción de hormona paratiroidea, generalmente debido a un adenoma, e hipercalcemia. Su presentación clásica se diagnostica con la determinación de calcio sérico y de hormona paratiroidea, asociada con estudios de imágenes. Su tratamiento es quirúrgico y tiene altas tasas de éxito. Se analiza el caso de una paciente hipertensa, de 63 años, con historia de pérdida de apetito y debilidad de un año y medio de evolución, por lo que se le...

  1. La Violencia Latinoamericana vista por los Economistas

    Directory of Open Access Journals (Sweden)

    Salama Pierre

    2003-08-01

    Full Text Available

    Salama, Pierre. "La Violencia Lationoamericana vista por los Economistas", Cuadernos de Economía, V. XXII, n. 38, Bogotá, 2003 páginas 179-198.

    Este articulo sintetiza los estudios económicos publicados recientemente sobre la violencia en América Latina y analiza las causas suceptibles a acrecentarla: pobreza, desigualdad de los ingresos en nivel y variación, impunidad, diferencia entre la probabilidad de ser arrestado y la severidad de la pena impuesta, y narcotrafico. Sin embargo, la explicación de la violencia no se limitará a los factores económicos, puesto que el autor privilegia un enfoque inspirado en la antropología y la sociología.

  2. Síndrome cerebeloso por amiodarona

    Directory of Open Access Journals (Sweden)

    Neuda S. Garretto

    1994-12-01

    Full Text Available La amiodarona (AMD es una droga antiarritmica cuyos efectos adversos pueden comprometer el sistema nervioso central y periferico. La aparición de un síndrome cerebeloso es infrecuente. Se presenta un paciente masculino de 56 anos de edad que desarolla un síndrome pancerebeloso de 4 meses de evolución, que revierte luego de la suspension de la AMD. El cuadro reaparece meses mas tarde luego de un periodo de automedicacion con la droga. Los mecanismos tóxicos por los cuales la AMD afecta al cerebelo permanecen inciertos. Esta droga de amplia difusión en nuestro medio, como otros antiarritmicos, posee efectos sobre el sistema nervioso que deben ser tenidos en cuenta a fin de poder detectarlos precozmente.

  3. Vayamos por partes... dijo Jack el Destripador

    Directory of Open Access Journals (Sweden)

    Miguel Baños González

    2012-04-01

    Full Text Available En la cada día más compleja actividad de comunicación comercial, la publicidad es solamente una herramienta más con diferentes grados de importancia en función del tipo de anunciante. La tendencia a dividir el proceso creativo hasta definir una estructura de fases sucesivas, y en muchos casos de obligado seguimiento, es una visión que se aleja notablemente de la práctica profesional y de la realidad de un mercado holista y global. Por eso, proponemos un cambio de enfoque, analizando la creatividad publicitaria desde una perspectiva que nos permita un conocimiento más profundo, tanto desde punto de vista académico como desde el profesional. 

  4. Toxicidad por óxido de etileno

    Directory of Open Access Journals (Sweden)

    Téllez M. Jairo A.

    1993-08-01

    Full Text Available

    El óxido de etileno, es un compuesto epóxido gaseoso, ampliamente utilizado en nuestro medio como agente esterilizante y de desinfección en instituciones hospitalarias. Los estudios realizados en varios países han demostrado efectos sobre la salud humana, caracterizados por  hipersensibilidad dérmica, irritación del tracto respiratorio, irritación ocular, excitación del S.N.C. y se asocia con presencia de abortos expontáneos, aberraciones cromosómicas e irritación crónica de laringe y tráquea en personal expuesto ocupacionalmente.

  5. fluidizado por proceso autotérmico

    Directory of Open Access Journals (Sweden)

    ZULAMITA ZAPATA BENABITHE

    2005-01-01

    Full Text Available El presente trabajo se basa en el estudio de la producción de carbón activado a partir de carbón mineral subbituminoso en un reactor de lecho fluidizado por proceso autotérmico. El carbón utilizado provino de la región de Amagá (Antioquia - Colombia y fue activado en dos reactores de lecho fluidizado de diferente diámetro interno, 10 cm y 22 cm. Los valores del área superficial específica y el volumen de poro de las muestras activadas fueron determinados a partir de las isotermas de N2 y CO2. Los resultados experimentales mostraron que los valores de áreas superficiales BET y DR y del Índice de Yodo se encontraron alrededor de 460 m2/g (SBET, 490 m2/g (SDR y 460 mg I2/g carbón.

  6. Herida por arma de fuego Gunshot wounds

    OpenAIRE

    A. Sibón Olano; P. Martínez-García; E. Santiago Romero

    2003-01-01

    En el examen de las heridas por arma de fuego, hay que prestar especial interés al orifico de entrada. Un examen minucioso del mismo, nos permitirá conocer la distancia a la que se ha efectuado el disparo; así mismo, nos orientará sobe la trayectoria y etiología médico-legal. El tipo de arma puede modificar en alguna medida el orificio de entrada en los disparos a cañón tocante; como ocurre en las armas de dos cañones, en las que tiene situada su mira en la boca del cañón, o en las que están ...

  7. Choque séptico por ehrliquiosis

    Directory of Open Access Journals (Sweden)

    Viviana Hernández-de Mezerville

    2007-04-01

    Full Text Available La ehrliquiosis humana es una infección zoonótica transmitida por "garrapatas duras" causada por Anaplasma sp y Ehrlichia sp. Puede presentarse como un cuadro pseudogripal con fiebre, malestar general, mialgias y cefalea o hasta un choque séptico con falla multiorgánica y muerte. La mitad de los pacientes requieren atención hospitalaria en algún momento y se reporta una mortalidad de hasta el 5% secundaria a enfermedades oportunistas o a hemorragias. El diagnóstico se puede sospechar visualizando las mórulas intracitoplasmáticas en las células afectadas en frotis de sangre periférica, y se confirma con serología, con cultivos o con detección molecular. El tratamiento de elección es la doxiciclina con buena respuesta clínica. Se reporta un caso probable de ehrliquiosis humana asociado a choque séptico y falla multiorgánica tratado exitosamente en el Hospital Dr. Rafael Angel Calderón Guardia.Human ehrlichiosis is a tick-borne infectious disease caused by Anaplasma sp and Ehrlichia sp. The presentation can range from a flu-like syndrome with fever, malaise, myalgia and headache to a septic shock state with multiorganic dysfunction. Half the patients require in- hospital care and the mortality rate is 5% as a result of opportunistic infections or hemorrhage. The diagnosis can be made by the visualization of intracytoplasmatic morulae in the blood smear, serology, cultives or polymerase chain reaction. The treatment of choice is doxycicline and generally carries a good response. We report a case of human ehrlichiosis associated with septic shock and multiorganic dysfunction successfully treated at the Calderon Guardia Hospital.

  8. Hiperparatiroidismo primario por adenoma paratiroideo mediastinal

    Directory of Open Access Journals (Sweden)

    Jeffry Solís-Torres

    2015-06-01

    Full Text Available El hiperparatiroidismo primario cursa con un aumento de la secreción de hormona paratiroidea, generalmente debido a un adenoma, e hipercalcemia. Su presentación clásica se diagnostica con la determinación de calcio sérico y de hormona paratiroidea, asociada con estudios de imágenes. Su tratamiento es quirúrgico y tiene altas tasas de éxito. Se analiza el caso de una paciente hipertensa, de 63 años, con historia de pérdida de apetito y debilidad de un año y medio de evolución, por lo que se le realizaron exámenes de laboratorio que revelaron hipercalcemia y elevación de la hormona paratiroidea. Se le indicó entonces una gamagrafía con Tecnecio 99, que evidenció un nódulo de 18mm de diámetro, ubicado 2 centímetros caudal al lóbulo tiroideo derecho. Se le efectuó una exploración cervical sin encontrarse la lesión, por lo que requirió una esternotomía media superior, que permitió encontrar un adenoma en el mediastino superior, detrás de la vena braquiocefálica derecha, de manera que se procedió a su extracción. Los controles de calcio y de hormona paratiroidea a las 24 horas estaban entre los límites normales, y se egresó.

  9. Intercomparison of alpha particle spectrometry software packages

    International Nuclear Information System (INIS)

    Software has reached an important level as the 'logical controller' at different levels, from a single instrument to an entire computer-controlled experiment. This is also the case for software packages in nuclear instruments and experiments. In particular, because of the range of applications of alpha-particle spectrometry, software packages in this field are often used. It is the aim of this intercomparison to test and describe the abilities of four such software packages. The main objectives of the intercomparison were the ability of the programs to determine the peak areas and the peak area uncertainties, and the statistical control and stability of reported results. In this report, the task, methods and results of the intercomparison are presented in order to asist the potential users of such software and to stimulate the development of even better alpha-particle spectrum analysis software

  10. Alpha Decay, Shell Structure, and New Elements

    Institute of Scientific and Technical Information of China (English)

    PENZhong-Zhou; TAIFei; SHENWen-Qing

    2003-01-01

    We systematically analyze the experimental data of alpha decay in even-even heavy nuclei far from stability and find that the Geiger-Nuttall law brea~s for an isotopic chain when its neutron number is across a marc number or there is a deformed subshell. This break can be used to identify new magic numbers of superheavy nuclei. It is also discovered that there is a new linear relation between the logarithm of half-life and the reciprocal of the square root of decay energy for N = 126 and N = 152 isotones. It could be a new law of alpha decay for nuclei with magic neutron numbers but the physics behind it is to be explored. The significance of these researches for the search of new elements is discussed.

  11. Alpha Decay, Shell Structure, and New Elements

    Institute of Scientific and Technical Information of China (English)

    REN Zhong-Zhou; TAI Fei; SHEN Wen-Qing

    2003-01-01

    We systematically analyze the experimental data of alpha decay in even-even heavy nuclei far from stabilityand find that the Geiger-Nuttall law breaks for an isotopic chain when its neutron number is across a magic numberor there is a deformed subshell. This break can be used to identify new magic numbers of superheavy nuclei. It is alsodiscovered that there is a new linear relation between the logarithm of half-life and the reciprocal of the square root ofdecay energy for N = 126 and N = 152 isotones. It could be a new law of alpha decay for nuclei with magic neutronnumbers but the physics behind it is to be explored. The significance of these researches for the search of new elementsis discussed.

  12. Alpha-Irradiation-Induced Doping of Si

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun Je; Kong, Young Bae; Hur, Min Goo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    A method to dope Si was presented on the base of the alpha irradiation. After the alpha irradiation, P atoms were created from Si atoms by nuclear transmutation while the microstructure of Si surfaces was almost unchanged. As the fluence increased, the amount of P atoms on the Si surface was also increased. It has been revealed that semiconducting materials can be doped by nuclear reactions. Those reactions can be induced by thermal neutrons, high energy charged particles and photons. Among them, researches on neutron transmutation doping have been intensively performed. Furthermore, this method has been widely used for the production of P-doped Si in semiconductor industries. However, researches on nuclear doping induced by charged particles were rarely carried out relatively.

  13. Alpha-contaminated waste management workshop

    International Nuclear Information System (INIS)

    These proceedings are published to provide a record of the oral presentations made at the DOE Alpha-Contaminated Workshop held in Gaithersburg, Maryland, on August 10-13, 1982. The papers are transcriptions of these oral presentations and, as such, do not contain as significant detail as will be found in the reviewed papers to be published in the periodical Nuclear and Chemical Waste Management in the first issue for 1983. These transcriptions have been reviewed by the speakers and some illustrations have been provided, but these contain only the preliminary information that will be provided in the technical papers to be published in the periodical. These papers have been grouped under the following headings: source terms; disposal technology and practices for alpha-contaminated waste; risk analyses and safety assessments. These papers in addition to those dealing with legislative and regulatory aspects have been abstracted and indexed for the Energy Data Base

  14. Sneutrino Inflation with $\\alpha$-attractors

    CERN Document Server

    Kallosh, Renata; Roest, Diederik; Wrase, Timm

    2016-01-01

    Sneutrino inflation employs the fermionic partners of the inflaton and stabilizer field as right-handed neutrinos to realize the seesaw mechanism for light neutrino masses. A crucial ingredient in existing constructions for sneutrino (multi-)natural inflation is an unbroken discrete shift symmetry. We demonstrate that a similar construction applies to $\\alpha$-attractor models. In this case the hyperbolic geometry protects the neutrino Yukawa couplings to the inflaton field, and the masses of leptons and Higgs fields, from blowing up when the inflaton is super-Planckian. We find that the predictions for $n_s$ and $r$ for $\\alpha$-attractor cosmological models, compatible with the current cosmological data, are preserved in the presence of the neutrino sector.

  15. Source preparations for alpha and beta measurements

    Energy Technology Data Exchange (ETDEWEB)

    Holm, E. [Risoe National Lab., Roskilde (Denmark)

    2001-01-01

    Regarding alpha particle emitters subject for environmental studies, electrodeposition or co-precipitation as fluorides are the most common methods. For electro deposition stainless steel is generally used as cathode material but also other metals such as Ni, Ag, and Cu showed promising results. The use of other anode material than platinum, such as graphite should be investigated. For other purposes such as optimal resolution other more sophisticated methods are used but often resulting in poorer recovery. For beta particle emitters the type of detection system will decide the source preparation. Similar methods as for alpha particle emitters, electrodeposition or precipitation techniques can be used. Due to the continuous energy distribution of the beta pulse height distribution a high resolution is not required. Thicker sources from the precipitates or a stable isotopic carrier can be accepted but correction for absorption in the source must be done. (au)

  16. Strong absorption model analysis of alpha scattering

    International Nuclear Information System (INIS)

    Angular distribution of alpha-particles at several energies, Eα = 21 ∼ 85.6 MeV from a number of nuclei between 20Ni and 119Sn, extending to wide angular range up to ∼ 160 deg. C in some cases, have been analyzed in terms of three-parameter strong absorption model of Frahn and Venter. Interaction radius and surface diffuseness are obtained from the parameter values rendering the best fit to the elastic scattering data. The inelastic scattering of alpha-particles from a number of nuclei, leading to quadrupole and octupole excitations has also been studied giving the deformation parameters βL. (author). 14 refs, 7 figs, 3 tabs

  17. Gravitational waves in $\\alpha-$attractors

    CERN Document Server

    Kumar, K Sravan; Moniz, Paulo Vargas; Das, Suratna

    2015-01-01

    We study inflation in the $\\alpha-$attractor model under a non-slow-roll dynamics with an ansatz proposed by Gong \\& Sasaki \\cite{Gong:2015ypa} of assuming $N=N\\left(\\phi\\right)$. Under this approach, we construct a class of local shapes of inflaton potential that are different from the T-models. We find this type of inflationary scenario predicts an attractor at $n_{s}\\sim0.967$ and $r\\sim0.00055$. In our approach, the non-slow-roll inflaton dynamics are related to the $\\alpha-$parameter which is the curvature of K\\"ahler geometry in the SUGRA embedding of this model.

  18. Possibilities of life around Alpha Centauri B

    CERN Document Server

    Gonzalez, Antolin; Hearnshaw, John

    2014-01-01

    We make a preliminary assessment on the habitability of potential rocky exoplanets around Alpha Centauri B. We use several indexes: the Earth Similarity Index, a mathematical model for photosynthesis, and a biological productivity model. Considering the atmospheres of the exoplanets similar to current Earth's atmosphere, we find consistent predictions of both the Earth Similarity Index and the biological productivity model. The mathematical model for photosynthesis clearly failed because does not consider the temperature explicitly. For the case of Alpha Centauri B, several simulation runs give 11 planets in the habitable zone. Applying to them above mentioned indexes, we select the five exoplanets more prone for photosynthetic life; showing that two of them in principle have better conditions than Earth for this kind of life.

  19. Registration probability of alphas in cellulose nitrate

    International Nuclear Information System (INIS)

    Registration 'thresholds' of alpha particles in cellulose nitrate plastic present a statistical behaviour. The effect depends on etching conditions. It is particularly large in strong etching conditions, in which registration is transposed to high energies: up to 7.7 MeV for the conditions and energies studied. 'Registration probability' expresses more adequately the effect of registration constraints. The study of registration probability indicates that the 'target theory' can describe the effect. The parameters of target theory, m (number of targets) and D0 (the equivalent of biological dose D37) were found to be: m = 5 and D0 = 3 x 107 erg cm-3. Dose distribution around the trajectory of alphas of various energies is estimated. It is also deduced that track development takes place when the required dose for registration is deposited at a distance r >= 20 A from particle trajectory. (author)

  20. Dificuldades na identificação laboratorial da talassemia alfa Difficulty on laboratory identification of alpha thalassemia

    Directory of Open Access Journals (Sweden)

    Karlla Greick Batista Dias-Penna

    2010-04-01

    Full Text Available Introdução: Talassemia alfa é uma síndrome associada à redução da síntese de cadeias de globina do tipo alfa. A gravidade das manifestações clínicas está relacionada com a quantidade de globinas produzida e a estabilidade das cadeias beta presentes em excesso. A talassemia alfa mínima resulta da deleção de apenas um dos quatro genes a (-α/αα. Clinicamente apresenta anemia leve com microcitose ou ausência de anemia, sendo o diagnóstico realizado por meio de visualização da hemoglobina (Hb H por eletroforese alcalina em acetato de celulose ou por identificação de inclusões celulares de Hb H coradas pelo azul de crezil brilhante. Objetivo: Avaliar portadores de talassemia alfa e seus respectivos progenitores, correlacionando perfil hematológico e presença de Hb H, utilizando procedimentos laboratoriais clássicos em três diferentes amostragens. Discussão e conclusão: Os dados obtidos mostram que a presença de Hb H, indicativo de talassemia alfa, pode não ser confirmada em uma análise posterior. Entre os fatores que podem influenciar no não aparecimento de Hb H em pessoa comprovadamente com talassemia alfa está a deficiência de ferro. A talassemia alfa está associada a defeitos envolvendo os genes codificadores da cadeia alfa, mas também pode estar relacionada com desbalanciamento temporário na expressão dos genes globina, diminuição de alfa ou aumento de beta, o que poderia explicar o aparecimento de tetrâmeros de cadeia beta (Hb H, sugerindo diagnóstico de talassemia alfa mínima.Introduction: Alpha thalassemia is a syndrome with associated with the reduction of alpha globin chain synthesis. The severity of clinical manifestations is related to the amount of globins produced and the stability of beta chains that are present in excess. Alpha thalassemia minor is caused by the deletion of one of the four genes a (-α/αα. Clinically, it presents mild anemia with microcytosis or absence of anemia. The

  1. Proceedings, High-Precision $\\alpha_s$ Measurements from LHC to FCC-ee

    Energy Technology Data Exchange (ETDEWEB)

    d' Enterria, David [CERN; Skands, Peter Z. [Monash U.

    2015-01-01

    This document provides a writeup of all contributions to the workshop on "High precision measurements of $\\alpha_s$: From LHC to FCC-ee" held at CERN, Oct. 12--13, 2015. The workshop explored in depth the latest developments on the determination of the QCD coupling $\\alpha_s$ from 15 methods where high precision measurements are (or will be) available. Those include low-energy observables: (i) lattice QCD, (ii) pion decay factor, (iii) quarkonia and (iv) $\\tau$ decays, (v) soft parton-to-hadron fragmentation functions, as well as high-energy observables: (vi) global fits of parton distribution functions, (vii) hard parton-to-hadron fragmentation functions, (viii) jets in $e^\\pm$p DIS and $\\gamma$-p photoproduction, (ix) photon structure function in $\\gamma$-$\\gamma$, (x) event shapes and (xi) jet cross sections in $e^+e^-$ collisions, (xii) W boson and (xiii) Z boson decays, and (xiv) jets and (xv) top-quark cross sections in proton-(anti)proton collisions. The current status of the theoretical and experimental uncertainties associated to each extraction method, the improvements expected from LHC data in the coming years, and future perspectives achievable in $e^+e^-$ collisions at the Future Circular Collider (FCC-ee) with $\\cal{O}$(1--100 ab$^{-1}$) integrated luminosities yielding 10$^{12}$ Z bosons and jets, and 10$^{8}$ W bosons and $\\tau$ leptons, are thoroughly reviewed. The current uncertainty of the (preliminary) 2015 strong coupling world-average value, $\\alpha_s(m_Z)$ = 0.1177 $\\pm$ 0.0013, is about 1\\%. Some participants believed this may be reduced by a factor of three in the near future by including novel high-precision observables, although this opinion was not universally shared. At the FCC-ee facility, a factor of ten reduction in the $\\alpha_s$ uncertainty should be possible, mostly thanks to the huge Z and W data samples available.

  2. The predominantly nonhydrolytic action of alpha amylases on alpha-maltosyl fluoride.

    Science.gov (United States)

    Okada, G; Genghof, D S; Hehre, E J

    1979-06-01

    Crystalline alpha amylases from a number of sources utilized alpha-maltosyl fluoride as a glycosyl donor and acceptor at high rates (approximately 10 to approximately 1550 mumol/min/mg of protein, for 30 mM substrate). All enzymes catalyzed conversion of this compound into maltooligosaccharides in preference to causing its hydrolysis. Maltotetraosyl flouride and maltooligosaccharides of d.p. 3 to 6+ accounted for 75--93% (by weight) of early reaction-products. At a late stage, the yield of maltooligosaccharides was 2--5 times that of maltose, with chains as long as 12 D-glucosyl residues formed by one amylase (from Asp. oryzae), which utilized alpha-maltosyl fluoride as a donor and as an acceptor at extremely high rates. These results indicate that alpha amylases have a substantial capacity for binding two molecules of this small substrate in a distinctive way, with the C--F glycosylic bond of one and the free C-4 hydroxyl group of the other located in the region of the enzyme's catalytic groups, therby favoring glycosylation of the suitably positioned acceptor over solvent water. Hydrolysis is assumed to prevail when only a single substrate molecule or segment binds to alpha amylase with a (1 linked to 4)-alpha-D-glucosidic linkage of glycosylic C--F bond positioned at the catalytic center. The present demonstration that glycosyl-transfer reactions can be dominantly expressed by alpha amylases, given an appropriate substrate, illustrates the inadequacy of the usual characterization of these enzymes as hydrolases that produce overwhelming hydrolysis of all substrates.

  3. Dark Energy from $\\alpha$-Attractors

    CERN Document Server

    Linder, Eric V

    2015-01-01

    A class of inflation theories called $\\alpha$-attractors has been investigated recently with interesting properties interpolating between quadratic potentials, the Starobinsky model, and an attractor limit. Here we examine their use for late time cosmic acceleration. We generalize the class and demonstrate how it can interpolate between thawing and freezing dark energy, and reduce the fine tuning of initial conditions, allowing $w\\approx-1$ for a prolonged period or as a de Sitter attractor.

  4. Heterodiffusion coefficients in alpha-iron

    Energy Technology Data Exchange (ETDEWEB)

    Katsika-Tsigourakou, Vassiliki, E-mail: vkatsik@phys.uoa.g [Department of Solid State Physics, Faculty of Physics, University of Athens, Panepistimiopolis Zografos, 15784 Athens (Greece); Skordas, Efthimios S. [Department of Solid State Physics, Faculty of Physics, University of Athens, Panepistimiopolis Zografos, 15784 Athens (Greece)

    2010-04-01

    The diffusion of tungsten in alpha-iron is important for the application of ferritic-iron alloys to thermal power plants. These data, over a wide temperature range across the Curie temperature, have been recently reported. We show that these diffusion coefficients can be satisfactory reproduced in terms of the bulk elastic and expansivity data by means of a thermodynamical model that interconnects point defects parameters with bulk qualities.

  5. Effects of internally deposited alpha emitters

    International Nuclear Information System (INIS)

    This study seeks to identify and quantify the human health effects of occupational exposures to radium, use the health effects data from the radium study to predict responses to other alpha-emitting and/or bone-seeking radionuclides at occupational exposure levels and above, and predict the effects of these radionuclides, specifically environmental radium and its daughters, at nonoccupational exposure levels. 14 refs

  6. Effect of Pilates Training on Alpha Rhythm

    OpenAIRE

    Zhijie Bian; Hongmin Sun; Chengbiao Lu; Li Yao; Shengyong Chen; Xiaoli Li

    2013-01-01

    In this study, the effect of Pilates training on the brain function was investigated through five case studies. Alpha rhythm changes during the Pilates training over the different regions and the whole brain were mainly analyzed, including power spectral density and global synchronization index (GSI). It was found that the neural network of the brain was more active, and the synchronization strength reduced in the frontal and temporal regions due to the Pilates training. These results support...

  7. Alpha particles energy straggling in noble gases

    International Nuclear Information System (INIS)

    The comparison of the calculated spectra by the Monte-Carlo simulation with the experimental alpha-particles spectra after their passage through noble gases target has good agreement for Ar, Kr, and Xe and significant deviation for He and Ne. These agreement or disagreement of the calculated and experimental spectra were ascribed to adequacy or inadequacy of the applied Bohr's charged particles energy loss formula for the specific medium. (author)

  8. Weather Radar Signals with Alpha Stable Distributions

    OpenAIRE

    Lagha, Mohand; Bensebti, Messaoud

    2007-01-01

    This work, treats about a modeling of the weather precipitation echoes detected by a weather pulse Doppler radar. The methods used for the simulation of the Doppler spectrum, and I & Q signals representing the precipitations radar echoes, is based on a macroscopic models, i.e. random processes with assigned spectra. We propose global model, with a power spectrum having a range of statistical distributions ranging between Cauchy and Gauss called alpha-stable model. The results obtained shows t...

  9. Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha.

    Science.gov (United States)

    Dietrich, Christoph G; Martin, Ina V; Porn, Anne C; Voigt, Sebastian; Gartung, Carsten; Trautwein, Christian; Geier, Andreas

    2007-09-01

    Fasting induces numerous adaptive changes in metabolism by several central signaling pathways, the most important represented by the HNF4alpha/PGC-1alpha-pathway. Because HNF4alpha has been identified as central regulator of basolateral bile acid transporters and a previous study reports increased basolateral bile acid uptake into the liver during fasting, we hypothesized that HNF4alpha is involved in fasting-induced bile acid uptake via upregulation of basolateral bile acid transporters. In rats, mRNA of Ntcp, Oatp1, and Oatp2 were significantly increased after 48 h of fasting. Protein expression as determined by Western blot showed significant increases for all three transporters 72 h after the onset of fasting. Whereas binding activity of HNF1alpha in electrophoretic mobility shift assays remained unchanged, HNF4alpha binding activity to the Ntcp promoter was increased significantly. In line with this result, we found significantly increased mRNA expression of HNF4alpha and PGC-1alpha. Functional studies in HepG2 cells revealed an increased endogenous NTCP mRNA expression upon cotransfection with either HNF4alpha, PGC-1alpha, or a combination of both. We conclude that upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway.

  10. Hypoxia inducible factor-1-alpha (HIF-1 alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis

    NARCIS (Netherlands)

    Brouwer, E.; Gouw, A. S. H.; Posthumus, M. D.; van Leeuwen, M. A.; Boerboom, A. L.; Bijzet, J.; Limburg, P. C.; Kallenberg, C. G. M.; Westra, J.; Bos, R

    2009-01-01

    Objectives Despite the important role of the transcription factor HIF-1 alpha in angiogenesis and inflammation, only a few studies on HIF-1 alpha expression have been performed in RA patients. The aim of the present study was to identify the layer in synovial tissue of RA patients where HIF1 alpha i

  11. Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha.

    Science.gov (United States)

    Dietrich, Christoph G; Martin, Ina V; Porn, Anne C; Voigt, Sebastian; Gartung, Carsten; Trautwein, Christian; Geier, Andreas

    2007-09-01

    Fasting induces numerous adaptive changes in metabolism by several central signaling pathways, the most important represented by the HNF4alpha/PGC-1alpha-pathway. Because HNF4alpha has been identified as central regulator of basolateral bile acid transporters and a previous study reports increased basolateral bile acid uptake into the liver during fasting, we hypothesized that HNF4alpha is involved in fasting-induced bile acid uptake via upregulation of basolateral bile acid transporters. In rats, mRNA of Ntcp, Oatp1, and Oatp2 were significantly increased after 48 h of fasting. Protein expression as determined by Western blot showed significant increases for all three transporters 72 h after the onset of fasting. Whereas binding activity of HNF1alpha in electrophoretic mobility shift assays remained unchanged, HNF4alpha binding activity to the Ntcp promoter was increased significantly. In line with this result, we found significantly increased mRNA expression of HNF4alpha and PGC-1alpha. Functional studies in HepG2 cells revealed an increased endogenous NTCP mRNA expression upon cotransfection with either HNF4alpha, PGC-1alpha, or a combination of both. We conclude that upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway. PMID:17640976

  12. Alpha effect and turbulent diffusion from convection

    CERN Document Server

    Käpylä, P J; Brandenburg, A

    2008-01-01

    (abridged) Aims: To study turbulent transport coefficients that describe the evolution of large-scale magnetic fields in turbulent convection. Methods: We use the test field method together with 3D numerical simulations of turbulent convection with shear and rotation to compute turbulent transport coefficients describing the evolution of large-scale magnetic fields in mean-field theory in the kinematic regime. 1D mean-field models are used with the derived turbulent transport coefficients to compare with direct simulations. Results: The alpha-effect increases monotonically as rotation increases. Turbulent diffusivity, eta_t, is proportional to the square of the turbulent vertical velocity. Whereas eta_t decreases approximately inversely proportional to the wavenumber of the field, the alpha-effect and turbulent pumping show a more complex behaviour. In the presence of shear and no rotation a small alpha-effect is induced which does not seem to show any consistent trend as a function of shear. If the shear is ...

  13. Lyman Alpha Mapping Project (LAMP) Brightness Maps

    Science.gov (United States)

    Retherford, Kurt D.; Gladstone, G.; Stern, S.; Egan, A. F.; Miles, P. F.; Parker, J. W.; Greathouse, T. K.; Davis, M. W.; Slater, D. C.; Kaufmann, D. E.; Versteeg, M. H.; Feldman, P. D.; Hurley, D. M.; Pryor, W. R.; Hendrix, A. R.

    2010-10-01

    The Lyman Alpha Mapping Project (LAMP) is an ultraviolet (UV) spectrograph on the Lunar Reconnaissance Orbiter (LRO) that is designed to map the lunar albedo at far-UV wavelengths. LAMP primarily measures interplanetary Hydrogen Lyman-alpha sky-glow and far-UV starlight reflected from the night-side lunar surface, including permanently shadowed regions (PSRs) near the poles. Dayside observations are also obtained. Brightness maps sorted by wavelength (including the Lyman-alpha wavelength of 121.6 nm) are reported for the polar regions, with a few regions of interest reported in more detail. LAMP's spectral range of 58 nm to 196 nm includes a water ice spectral feature near 160 nm, which provides a diagnostic tool for detecting water on the lunar surface that is complementary to recent discoveries using infrared and radio frequency techniques. Progress towards producing far-UV albedo maps and searching for water ice signatures will be reported. We'll discuss how LAMP data may address questions regarding how water is formed on the moon, transported through the lunar atmosphere, and deposited in the PSRs.

  14. Varying alpha from N-body Simulations

    CERN Document Server

    Li, Baojiu; Barrow, John D

    2010-01-01

    We have studied the Bekenstein-Sandvik-Barrow-Magueijo (BSBM) model for the spatial and temporal variations of the fine structure constant, alpha, with the aid of full N-body simulations which explicitly and self-consistently solve for the scalar field driving the alpha-evolution. We focus on the scalar field (or equivalently alpha) inside the dark matter halos and find that the profile of the scalar field is essentially independent of the BSBM model parameter. This means that given the density profile of an isolated halo and the background value of the scalar field, we can accurately determine the scalar field perturbation in that halo. We also derive an analytic expression for the scalar-field perturbation using the Navarro-Frenk-White halo profile, and show that it agrees well with numerical results, at least for isolated halos; for non-isolated halos this prediction differs from numerical result by a (nearly) constant offset which depends on the environment of the halo.

  15. Alpha Background Rejection in Bolometer Detectors

    Science.gov (United States)

    Deporzio, Nicholas; Cuore Collaboration

    This study presents the modification of bolometer detectors used in particle searches to veto or otherwise reject alpha radiation background and the statistical advantages of doing so. Several techniques are presented in detail - plastic film scintillator vetoes, metallic film ionization vetoes, and Cherenkov radiation vetoes. Plastic scintillator films are cooled to bolometer temperatures and bombarded with 1.4MeV to 6.0MeV alpha particles representative of documented detector background. Quantum dot based liquid scintillator is similarly bombarded to produce a background induced scintillation light. Photomultipliers detect this scintillation light and produce a veto signal. Layered metallic films of a primary metal, dielectric, and secondary metal, such as gold-polyethylene-gold films, are cooled to milli-kelvin temperatures and biased to produce a current signal veto when incident 1.4MeV to 6.0MeV alpha particles ionize conduction paths through the film. Calibration of veto signal to background energy is presented. These findings are extrapolated to quantify the statistical impact of such modifications to bolometer searches. Effects of these techniques on experiment duration and signal-background ratio are discussed.

  16. The Alpha Dynamo Effects in Laboratory Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Hantao Ji; Stewart C. Prager

    2001-10-16

    A concise review of observations of the alpha dynamo effect in laboratory plasmas is given. Unlike many astrophysical systems, the laboratory pinch plasmas are driven magnetically. When the system is overdriven, the resultant instabilities cause magnetic and flow fields to fluctuate, and their correlation induces electromotive forces along the mean magnetic field. This alpha-effect drives mean parallel electric current, which, in turn, modifies the initial background mean magnetic structure towards the stable regime. This drive-and-relax cycle, or the so-called self-organization process, happens in magnetized plasmas in a timescale much shorter than resistive diffusion time, thus it is a fast and unquenched dynamo process. The observed alpha-effect redistributes magnetic helicity (a measure of twistedness and knottedness of magnetic field lines) but conserves its total value. It can be shown that fast and unquenched dynamos are natural consequences of a driven system where fluctuations are statistically either not stationary in time or not homogeneous in space, or both. Implications to astrophysical phenomena will be discussed.

  17. $\\alpha$ Centauri A in the far infrared

    CERN Document Server

    Liseau, R; Olofsson, G; Bryden, G; Marshall, J P; Ardila, D; Aran, A Bayo; Danchi, W C; del Burgo, C; Eiroa, C; Ertel, S; Fridlund, M C W; Krivov, A V; Pilbratt, G L; Roberge, A; Thébault, P; Wiegert, J; White, G J

    2012-01-01

    Chromospheres and coronae are common phenomena on solar-type stars. Understanding the energy transfer to these heated atmospheric layers requires direct access to the relevant empirical data. Study of these structures has, by and large, been limited to the Sun thus far. The region of the temperature reversal can be directly observed only in the far infrared and submm. We aim at the determination of the characteristics of the atmosphere in the region of the temperature minimum of the solar sister star alpha Cen A. For the nearby binary system alpha Centauri, stellar parameters are known with high accuracy from measurements. For the basic model parameters Teff, log g and [Fe/H], we interpolate in the grid of GAIA/PHOENIX stellar model atmospheres and compute the corresponding model for the G2 V star alpha Cen A. Comparison with photometric measurements shows excellent agreement between observed photospheric data in the optical and infrared. For longer wavelengths, the modelled spectral energy distribution is co...

  18. Synthesis and reactivity of {alpha}-phenylseleno-{beta}-substituted styrenes: preparation of (Z)-allyl alcohols, (E)-{alpha}-phenyl-{alpha},{beta}-unsaturated aldehydes and {alpha}-aryl acetophenones

    Energy Technology Data Exchange (ETDEWEB)

    Lenardao, Eder J.; Jacob, Raquel G.; Silva, Thiago B. da [Universidade Federal de Pelotas, RS (Brazil). Dept. de Quimica Analitica e Inorganica]. E-mail: lenardao@ufpel.edu.br; Cella, Rodrigo [Santa Maria Univ., RS (Brazil). Dept. de Quimica; Perin, Gelson [Universidade Federal de Pelotas, RS (Brazil). Dept. de Quimica Organica

    2006-09-15

    A new and efficient method was developed to prepare {alpha}-phenylseleno-{beta}-substituted styrenes by reaction of diethyl {alpha}-phenylseleno benzylphosphonate with NaH and aldehydes. Selenium-lithium exchange by reaction with n-BuLi yielded the vinyl lithium species, which were captured with several electrophiles, like aldehydes and DMF, affording exclusively (Z)-allyl alcohols, and (E)-{alpha}-phenyl-{alpha}-{beta}-unsaturated aldehydes, respectively in good yields. The hydrolysis of the vinyl selenides in presence of TiCl{sub 4} allowed the corresponding {alpha}-aryl acetophenones. (author)

  19. Alpha Particle Physics Experiments in the Tokamak Fusion Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Budny, R.V.; Darrow, D.S.; Medley, S.S.; Nazikian, R.; Zweben, S.J.; et al.

    1998-12-14

    Alpha particle physics experiments were done on the Tokamak Fusion Test Reactor (TFTR) during its deuterium-tritium (DT) run from 1993-1997. These experiments utilized several new alpha particle diagnostics and hundreds of DT discharges to characterize the alpha particle confinement and wave-particle interactions. In general, the results from the alpha particle diagnostics agreed with the classical single-particle confinement model in magnetohydrodynamic (MHD) quiescent discharges. Also, the observed alpha particle interactions with sawteeth, toroidal Alfvén eigenmodes (TAE), and ion cyclotron resonant frequency (ICRF) waves were roughly consistent with theoretical modeling. This paper reviews what was learned and identifies what remains to be understood.

  20. The Alpha-1A Adrenergic Receptor in the Rabbit Heart

    OpenAIRE

    R Croft Thomas; Cowley, Patrick M.; Abhishek Singh; Bat-Erdene Myagmar; Swigart, Philip M.; Baker, Anthony J.; Simpson, Paul C.

    2016-01-01

    The alpha-1A-adrenergic receptor (AR) subtype is associated with cardioprotective signaling in the mouse and human heart. The rabbit is useful for cardiac disease modeling, but data on the alpha-1A in the rabbit heart are limited. Our objective was to test for expression and function of the alpha-1A in rabbit heart. By quantitative real-time reverse transcription PCR (qPCR) on mRNA from ventricular myocardium of adult male New Zealand White rabbits, the alpha-1B was 99% of total alpha-1-AR mR...