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Sample records for alopecia

  1. Androgenetic alopecia.

    Science.gov (United States)

    Otberg, Nina; Finner, Andreas M; Shapiro, Jerry

    2007-06-01

    Androgenetic alopecia (AGA), or male pattern hair loss, affects approximately 50% of the male population. AGA is an androgen-related condition in genetically predisposed individuals. There is no treatment to completely reverse AGA in advanced stages, but with medical treatment (eg, finasteride, minoxidil, or a combination of both), the progression can be arrested and partly reversed in the majority of patients who have mild to moderate AGA. Combination with hair restoration surgery leads to best results in suitable candidates. Physicians who specialize in male health issues should be familiar with this common condition and all the available approved treatment options.

  2. Central centrifugal cicatricial alopecia

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    Collin Blattner

    2013-01-01

    Full Text Available Central centrifugal cicatricial alopecia is a common cause of progressive permanent apical alopecia. This unique form of alopecia includes entities previously know as "hot comb alopecia," "follicular degeneration syndrome," "pseudopelade" in African Americans and "central elliptical pseudopelade" in Caucasians. The etiology appears to be multifactorial and the condition occurs in all races.

  3. Living with Alopecia Areata

    Science.gov (United States)

    ... accept their alopecia areata, which may impact their self-esteem and social interaction. Learn more about the different ... Footer Contact Menu Partners Feedback Contact Social YouTube Facebook Twitter Copyright 2017 National Alopecia Areata Foundation | Privacy ...

  4. Alopecia caused by isoniazid

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    Ramakant Dixit

    2014-01-01

    Full Text Available Drug-induced alopecia is a known clinical entity and mainly seen with anti-mitotic drug therapy. Alopecia during anti-tuberculosis therapy is very uncommon and previously observed with isoniazid, thiacetazone, and ethionamide. Present communication describes an additional case of isoniazid-induced alopecia in a 10-year-old male child, which was reversible after isoniazid withdrawal. Possible mechanisms of drug-induced alopecia are also briefly discussed.

  5. [Feline paraneoplastic alopecia].

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    van der Luer, R; van den Ingh, T; van Hoe, N

    2008-03-01

    A 14-year-old neutered female cat was presented for a second opinion regarding hair loss, anorexia, and lethargy. Examination revealed alopecia of the ventral chest, abdomen, axilla, and groin. The footpads were encrusted. The liver was enlarged and nodular. Investigation revealed an enlarged liver with multiple nodules, and small and atrophic hair follicles. Paraneoplastic alopecia due to hepatocellular carcinoma was diagnosed and subsequently confirmed postmortem.

  6. Trichoscopy of Noncicatricial Pressure-induced Alopecia Resembling Alopecia Areata

    Science.gov (United States)

    Papaiordanou, Francine; da Silveira, Bruno Rebelo Lages; Piñeiro-Maceira, Juan; Pirmez, Rodrigo

    2016-01-01

    Pressure-induced alopecia is an unusual cause of hair loss, and reports of its trichoscopic features are scarce. In this paper, we describe a case of pressure-induced alopecia in which trichoscopic and histopathological findings overlap with those described for alopecia areata. PMID:27601865

  7. Alopecia areata update.

    Science.gov (United States)

    Hordinsky, Maria; Junqueira, Ana Lucia

    2015-06-01

    There is neither a cure for alopecia areata (AA) nor any universally proven therapy that induces and sustains remission in patients afflicted with this autoimmune disease. AA is characterized as a nonscarring alopecia which affects children and adults. It can be relatively easy to treat when the disease is patchy and limited; but when children and adults present with long standing extensive scalp and body hair loss, successful management can be challenging. Of the treatment choices available, physicians and midlevel providers usually select a cost-effective treatment approach based on disease duration, disease activity, age of the patient, and disease extent. In this manuscript, the clinical presentation, epidemiology, pathophysiology, plus current and evolving treatments for AA will be reviewed.

  8. Focal and generalized alopecia.

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    O'Dair, H A; Foster, A P

    1995-07-01

    Focal or generalized alopecia is defined as hair loss affecting the ventral, lateral, perineal, and dorsal aspects of the trunk of the cat, usually in a symmetric pattern. This may be attributable to failure of hair coat production, excess loss of hair due to self trauma, or excess shedding of whole hairs. Self trauma is the most common cause of hair loss and is associated particularly with flea allergy dermatitis. Other causes of hair loss are reviewed.

  9. Central centrifugal cicatricial alopecia.

    Science.gov (United States)

    Whiting, David A; Olsen, Elise A

    2008-01-01

    A progressive scarring alopecia of the central scalp is commonly seen in young to middle-aged females of African descent. It usually starts at the vertex or mid top of the scalp and gradually spreads centrifugally, hence, the unifying term of central centrifugal cicatricial alopecia. The clinical pattern is suggestive of female pattern alopecia, but a lack of follicular pores indicative of scarring is present. It can progress for years before slowly burning out. The etiology is unknown but genetic factors may be important. It is often associated with a history of traumatic hairstyling involving heat, traction, and chemicals. However, most patients of African descent without this disorder have similar styling habits. Nonetheless, avoidance of physical and chemical trauma to the scalp hair, the use of suitable shampoos and conditioners, and the encouragement of natural hairstyles may be helpful. Any infection should be treated. Topical or intralesional corticosteroids and systemic antibiotics may be useful and topical minoxidil should be tried with the hope of preventing further scarring and encouraging regrowth of recovering follicles. Current research into the etiology of this disorder will help to foster much-needed clinical trials of therapeutic agents.

  10. Psychosocial aspects of androgenetic alopecia

    NARCIS (Netherlands)

    A. van der Donk (Jos)

    1992-01-01

    textabstractThe main objective of the studies described in this thesis is to study the psychosocial problems of men and women with androgenetic alopecia who applied for treatment. In chapter 2, the psychological characteristics of 59 men with androgenetic alopecia from a sample of the general popula

  11. Relapsing Polychondritis Following Alopecia Areata

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    John C. Starr

    2010-01-01

    Full Text Available A case of alopecia areata followed by relapsing polychondritis is presented. Similar cases from the literature are reviewed and speculation about the relationship of these diseases is offered. Although the occurrence of these diseases together could be coincidental, an association seems immunologically plausible. Thus, relapsing polychondritis might be an unusual systemic manifestation of alopecia areata.

  12. Alopecia areata: An update

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    Kolalapudi Anjaneyulu Seetharam

    2013-01-01

    Full Text Available Alopecia areata (AA is a common form of non-scarring hair loss of scalp and/or body. Genetic predisposition, autoimmunity, and environmental factors play a major role in the etiopathogenesis of AA. Patchy AA is the most common form. Atopy and autoimmune thyroiditis are most common associated conditions. Peribulbar and intrabulbar lymphocytic inflammatory infiltrate resembling "swarm of bees" is characteristic on histopathology. Treatment is mainly focused to contain the disease activity. Corticosteroids are the preferred treatments in form of topical, intralesional, or systemic therapy. Camouflage in the form of wigs may be an alternative option in refractory cases.

  13. Central centrifugal cicatricial alopecia amalgamated with alopecia areata: immunologic findings

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    Ana Maria Abreu Velez

    2014-07-01

    Full Text Available Introduction: Both scarring and non-scarring alopecias exist; however, rare cases demonstrate features of both classes. Case Report: We describe an interesting alopecia case with amalgamated clinical, histologic and immunopathologic features of scarring and non-scarring alopecia. Specifically, the case displays combined features of alopecia areata (AA and of central centrifugal cicatricial alopecia (CCCA. A 36 year old female presented with symmetric, round, patchy hair loss on her scalp. Methods: Biopsies for hematoxylin and eosin (H&E examination, as well as for special stains, direct immunofluorescence (DIF and immunohistochemistry (IHC were performed. Results: The H&E biopsy revealed focally diminished hair follicular units, and sebaceous gland damage. Perifollicular concentric fibrosis was confirmed by Verhoeff elastin special staining. Antibodies to micelles were noted. Positive IHC staining for CD4, CD8, CD45 and multiple proteases and protease inhibitors was noted around selected follicular unit remnants. Conclusion: We present a rare alopecia, combining histologic features of CCCA with additional, selected immunologic features of AA.

  14. Plica neuropathica causing traction alopecia

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    Pavithran K

    1990-01-01

    Full Text Available A middle aged woman developed matting of the hairs of the scalp following use of a home made shampoo that contained leaves of Hibiscus rosasiensis. The entangled and matted hair mass in the occipital region pulled hairs of the vertex region of the scalp, resulting in a patch of traction alopecia. Release of tension on the hairs by cutting them with scissors prevented further extension of alopecia.

  15. Androgenetic alopecia in women.

    Science.gov (United States)

    Price, Vera H

    2003-06-01

    Androgenetic alopecia (AGA), also known in women as female pattern hair loss, is caused by androgens in genetically susceptible women and men. The thinning begins between ages 12 and 40 years, the inheritance pattern is polygenic, and the incidence is the same as in men. In susceptible hair follicles, dihydrotestosterone binds to the androgen receptor, and the hormone-receptor complex activates the genes responsible for the gradual transformation of large terminal follicles to miniaturized follicles. Both young women and young men with AGA have higher levels of 5alpha reductase and androgen receptor in frontal hair follicles compared to occipital follicles. At the same time, young women have much higher levels of cytochrome p-450 aromatase in frontal follicles than men who have minimal aromatase, and women have even higher aromatase levels in occipital follicles. The diagnosis of AGA in women is supported by early age of onset, the pattern of increased thinning over the frontal/parietal scalp with greater density over the occipital scalp, retention of the frontal hairline, and the presence of miniaturized hairs. Most women with AGA have normal menses and pregnancies. Extensive hormonal testing is usually not needed unless symptoms and signs of androgen excess are present such as hirsutism, severe unresponsive cystic acne, virilization, or galactorrhea. Topical minoxidil solution is the only drug available for promoting hair growth in women with AGA. Efficacy has been shown in double-blind studies using hair counts and hair weight.

  16. PHARMACOTHERAPY ALOPECIA ANDROGENETIC IN MEN

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    Riezky Januar Pramitha

    2013-03-01

    Full Text Available Androgenetic alopecia is hair thinning due to the stimulation of hair follicles to androgens. Incidence in men is higher than in women, it is because men have a degree higher 5? reductase. This condition can cause both physical and psychological effects to the patient. Physical effects due to baldness cause hair loss as a function of protection against heat, cold and trauma. While psychologically can affect self-esteem and self-perception of the patient. Androgenetic alopecia in men influenced by the androgen dihydrotestosterone and genetic predisposition, although the physiology remains unclear. Modality in the management of androgenetic alopecia in males patients including pharmacotherapy, hair transplants and cosmetic approach. According to the Food and Drug Administration (FDA, there are two main drugs are safe and effective in the long term given to men with androgenetic alopecia are minoxidil and finasteride. Although the mechanism of action and route of administration are different, but both drugs have similar effectiveness in stopping the progression of androgenetic alopecia in men.

  17. Alopecia areata in children : treatment with diphencyprone

    NARCIS (Netherlands)

    Schuttelaar, M L; Hamstra, J J; Plinck, E P; Peereboom-Wynia, J D; Vuzevski, V D; Mulder, P G; Oranje, A P

    1996-01-01

    We assessed the efficacy of diphencyprone (DPCP) treatment in a total of 26 children with alopecia areata (AA). Sixteen children had alopecia areata totalis (AAT) and 10 had alopecia areata localis (AAL). DPCP is an absolute contact sensitizer. Twenty-five children could be sensitized with a 2% DPCP

  18. Alopecia frontal fibrosante: relato de seis casos Frontal fibrosing alopecia: report of six cases

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    Fabiane Mulinari-Brenner

    2007-10-01

    Full Text Available Alopecia frontal fibrosante é forma progressiva de alopecia cicatricial. Os casos iniciais foram relatados a partir 1994, na Austrália, em pacientes do sexo feminino pós-menopausa. Desde então inúmeros casos foram descritos na literatura sugerindo que ela é mais prevalente do que inicialmente se supunha. Seu curso progressivo se assemelha ao da alopecia androgenética; histologicamente, entretanto, o infiltrado liquenóide é evidente. O artigo relata seis casos brasileiros e discute a alopecia frontal fibrosante dentro do grupo das alopecias cicatriciais, como variante do líquen plano pilar.Frontal fibrosing alopecia is a progressive cicatricial alopecia. The first cases were described in Australia in postmenopausal women, in 1994. Since then, numerous cases were reported, suggesting that frontal fibrosing alopecia is more prevalent than initially thought. Its progressive course in postmenopausal women, clinically resembles androgenetic alopecia; however, histologically, lichenoid infiltrate is evident. This article report six brazilian cases of frontal fibrosing alopecia and discusses them in the context of cicatricial alopecias, as a variant of lichen planopilaris.

  19. Psychiatric Symptoms in Patients with Alopecia Areata

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    Burak

    2011-12-01

    Full Text Available Background and Design: Alopecia areata is a chronic inflammatory disease characterized by sudden hair loss. Existing evidence suggests that alopecia areata may be associated with personality traits altering the susceptibility to stress and psychiatric conditions associated with stress. The aim of this study was to compare the intensity of depressive and anxiety symptoms and the level of alexithymia in patients with alopecia areata and healthy control subjects.Materials and methods: Fifty patients with the diagnosis of alopecia areata and 30 healthy volunteers were compared in terms of scores of Beck depression inventory, Beck anxiety inventory, and Toronto alexithymia scale.Results: There were no statistically significant differences between alopecia areata cases and healthy controls regarding intensity of anxiety and level of alexythimia (p=0.053 and p=0.120, respectively. The intensity of depressive symptoms exhibited by alopecia areata patients was found to be significantly higher than that in healthy controls (p=0.010 and there was no statistically significant relationship between intensity of depressive symptoms and duration of the current alopecia areata episode (p=0.873.Conclusion: It is suggested that psychiatric evaluation should also be performed in all alopecia areata cases during the clinical follow-up period. (Turk­derm 2011; 45: 203-5

  20. Female pattern alopecia: current perspectives

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    Levy LL

    2013-08-01

    Full Text Available Lauren L Levy, Jason J Emer Department of Dermatology, Mount Sinai School of Medicine, New York, NY, USA Abstract: Hair loss is a commonly encountered problem in clinical practice, with men presenting with a distinctive pattern involving hairline recession and vertex balding (Norwood-Hamilton classification and women exhibiting diffuse hair thinning over the crown (increased part width and sparing of the frontal hairline (Ludwig classification. Female pattern hair loss has a strikingly overwhelming psychological effect; thus, successful treatments are necessary. Difficulty lies in successful treatment interventions, as only two medications – minoxidil and finasteride – are approved for the treatment of androgenetic alopecia, and these medications offer mediocre results, lack of a permanent cure, and potential complications. Hair transplantation is the only current successful permanent option, and it requires surgical procedures. Several other medical options, such as antiandrogens (eg, spironolactone, oral contraceptives, cyproterone, flutamide, dutasteride, prostaglandin analogs (eg, bimatoprost, latanoprost, and ketoconazole are reported to be beneficial. Laser and light therapies have also become popular despite the lack of a profound benefit. Management of expectations is crucial, and the aim of therapy, given the current therapeutic options, is to slow or stop disease progression with contentment despite patient expectations of permanent hair regrowth. This article reviews current perspectives on therapeutic options for female pattern hair loss. Keywords: androgenetic alopecia, female pattern hair loss, minoxidil, finasteride, antiandrogens, spironolactone

  1. Neonatal occipital alopecia in a newborn

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    Anca Chiriac

    2014-07-01

    Full Text Available A newborn, male gender, born at term, APGAR 10, was addressed to us for occipital alopecia observed since birth (Fig. 1. Mother was a young health person of 25 years old, primipara and the birth was non-Caesarian delivery. Alopecia was confirmed in the occipital area, with no signs of inflammation or other dermatological problems on the whole body. A diagnosis of frictional/pressure occipital alopecia was admitted and the family was reassured of the absence of any inquiry.

  2. Vitiligo after Diphencyprone for Alopecia Areata

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    Pires, Mario Cezar; Martins, João Mauricio; Montealegre, F.; Gatti, Flávia Romero

    2010-01-01

    The topical immunotherapy is used to treat alopecia areata and recalcitrant warts since the 1970s. Diphencyprone is a contact sensitizer used to treat dermatological conditions resulting from as altered immunological state, such as extensive alopecia areata, being partially effective and safe. Side effects include local eczema with blistering, regional lymphadenopathy and contact urticaria. Rare adverse effects include an erythema multiforme-like reaction, hyperpigmenttion, hypopigmentation, and vitiligo. We report a 30-year-old, Brazilian male who developed vitiligo lesions following DPCP therapy for alopecia areata. PMID:20585597

  3. Vitiligo after Diphencyprone for Alopecia Areata

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    Mario Cezar Pires

    2010-01-01

    Full Text Available The topical immunotherapy is used to treat alopecia areata and recalcitrant warts since the 1970s. Diphencyprone is a contact sensitizer used to treat dermatological conditions resulting from as altered immunological state, such as extensive alopecia areata, being partially effective and safe. Side effects include local eczema with blistering, regional lymphadenopathy and contact urticaria. Rare adverse effects include an erythema multiforme-like reaction, hyperpigmenttion, hypopigmentation, and vitiligo. We report a 30-year-old, Brazilian male who developed vitiligo lesions following DPCP therapy for alopecia areata.

  4. Down syndrome, alopecia universalis, and trachyonychia.

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    Norton, S A; Demidovich, C W

    1993-06-01

    A 16-year-old boy with Down syndrome and alopecia universalis had dystrophy of all nails. A presumptive diagnosis of tinea unguium, common in persons with Down syndrome, had been made nine years earlier. Despite antifungal therapy, the condition of the nails worsened. We were unable to detect fungi, and believe that his nail changes are most consistent with alopecia-associated trachyonychia (formerly 20-nail dystrophy), a condition not previously reported in persons with Down syndrome.

  5. Atopy and alopecia areata in North Indians

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    Kaur Sukhjot

    2002-01-01

    Full Text Available The study was undertaken with the aim of evaluating the effect of associated atopy on severity and age at onset of alopecia areata in north Indians. Presence of atopy was elicited by detailed history, examination and intracutaneous tests. Chisquare test was carried out to evaluate statistical significance. One hundred patients (76 males and 24 females with alopecia areata were evaluated. Historical evidence of atopywas present in 50 including patients alone (23, patients and first degree relatives (11 and first degree relatives alone (16. Intracutaneous tests were positive in 23 out of 50 patients tested randomly. There was a trend towards increasing frequency of severe alopecia as evidence of atopy became stronger e.g. both patient and first degree relatives with atopy or positive intracutaneous test but the results did not attain statistical significance. Similarly the age at onset and duration of alopecia areata was not significantly related to the presence of atopy. It is concluded that in north Indians with alopecia areata, the presence of atopy is not significantly associated with severe alopecia or onset at younger age.

  6. Modified immunotherapy for alopecia areata.

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    Yoshimasu, Takashi; Furukawa, Fukumi

    2016-07-01

    Squaric acid dibutylester (SADBE) is a commonly used contact sensitizer in immunotherapy for alopecia areata (AA). Severe contact dermatitis is induced by the currently high recommended sensitization dose of 1%-2% SADBE, often decreasing patient compliance. We assessed a modified immunotherapy for AA using SADBE at a starting concentration of 0.01% without sensitization. After one or two weeks of initial 0.01% SADBE application, the concentration of SADBE was increased gradually to 0.025%, 0.05%, 0.1%, 0.25%, 0.5%, 1% and 2% until the patients felt itching or erythema at the AA lesion site. The modified immunotherapy showed a response rate of 69.4% (25/36), equivalent to conventional immunotherapy using SADBE starting at 1%-2% sensitization. Furthermore, we investigated the combination therapy of SADBE and multiple courses of steroid pulses for AA. The response rate for combination therapy was 73.7% (28/38); however, the group receiving combination therapy showed a significant prevalence of severe AA compared with the group receiving modified immunotherapy only. We reviewed the efficacy and safety of modified immunotherapy without initial sensitization and combination therapy with immunotherapy and multiple courses of pulses for AA.

  7. Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata - part II Desafio clínico e histológico no diagnóstico diferencial de alopecia difusa: alopecia androgenética, eflúvio telógeno e alopecia areata - parte II

    OpenAIRE

    2012-01-01

    Diffuse alopecia is mainly caused by telogen effluvium, diffuse androgenetic alopecia (femalepattern hair loss) and diffuse alopecia areata. Differential diagnosis between the three disorders may be difficult in several occasions. In this second part of our study, chronic telogen effluvium and diffuse alopecia areata are discussed in detail, including clinical, dermoscopic and histological aspects. A flowchart presents a practical and objective differential diagnostic approach to diffuse alop...

  8. Hair transplantation in alopecia due to radiation

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    Nordstroem, R.E.; Holsti, L.R.

    1983-10-01

    Two cases of alopecia due to radiation of the scalp are presented in which it has been possible to achieve a technically and cosmetically satisfactory reconstruction by punch hair grafting. This does not mean that every case is suitable, but it does mean that those without contraindications should at least be given a try.

  9. Central centrifugal cicatricial alopecia: challenges and solutions

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    Herskovitz I

    2016-08-01

    Full Text Available Ingrid Herskovitz, Mariya Miteva Department of Dermatology and Cutaneous Surgery, University of Miami L Miller School of Medicine, Miami, FL, USA Abstract: Central centrifugal cicatricial alopecia (CCCA is the most common scarring alopecia among African American women. Data about epidemiology, etiology, genetic inheritance, and management are scarce and come from individual reports or small series. CCCA has been associated with hot combing and traumatic hair styling for years; however, studies fail to confirm it as the sole etiologic factor. It has been shown in a small series that CCCA can be inherited in an autosomal dominant fashion, with a partial penetrance and a strong modifying effect of hairstyling and sex. CCCA presents clinically as a central area of progressive irreversible hair loss that expands to the periphery. A patchy form has also been described. Dermoscopy is helpful to identify the optimal site for the biopsy, which establishes the diagnosis. Well-designed randomized controlled trials are needed to discover the optimal management. At this point, patients are advised to avoid traction and chemical treatments; topical and intralesional steroids, calcineurin inhibitors, and minoxidil can be helpful in halting the progression. Keywords: hair loss, alopecia, dermatoscopy, dermoscopy, trichoscopy, black scalp, African American, scarring alopecia

  10. Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata - part II Desafio clínico e histológico no diagnóstico diferencial de alopecia difusa: alopecia androgenética, eflúvio telógeno e alopecia areata - parte II

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    Betina Werner

    2012-12-01

    Full Text Available Diffuse alopecia is mainly caused by telogen effluvium, diffuse androgenetic alopecia (femalepattern hair loss and diffuse alopecia areata. Differential diagnosis between the three disorders may be difficult in several occasions. In this second part of our study, chronic telogen effluvium and diffuse alopecia areata are discussed in detail, including clinical, dermoscopic and histological aspects. A flowchart presents a practical and objective differential diagnostic approach to diffuse alopecia.A alopecia difusa tem como principais causas eflúvio telógeno, alopecia androgenética difusa (alopecia androgenética de padrão feminino e alopecia areata difusa. Em muitas ocasiões o diagnóstico diferencial entre as três entidades é difícil. Na segunda parte deste artigo se discute em mais detalhes as características clínicas, dermatoscópicas e histológicas do eflúvio telógeno crônico e da alopecia areata difusa. Uma maneira prática e objetiva de abordagem diagnóstica da alopecia difusa é apresentada através de um fluxograma.

  11. A study of peripheral T-Lymphocytes in alopecia areata

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    Sharma R

    1995-01-01

    Full Text Available Estimation of peripheral T-lymphocytes (active and total was carried out in 100 cases of alopecia areata as per method described by Boyam (1977 and West et al (1978. Clinically patients were divided in two groups, alopecia areata circumscribed (group I and severe alopecia areata (group II. Thirty healthy subjects served as controls. Decrease in percentage of both active and total E-RFC was observed in 70% cases. The decrease was more significant in group II.

  12. Diffuse alopecia; nutritional factors and supplements

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    Güneş Gür Aksoy

    2014-06-01

    Full Text Available Hair is constantly produced and shed. The hair follicles producing the hair require calories, proteins, trace elements, and vitamins for this intense biosynthetic activity. Thus, hair growth quality and quantity are closely related to an individuals diet. The nutritional factors that are important for hair growth, and thus should be evaluated, and if deficient replaced in alopecias will be discussed in this review.

  13. Secondary cicatricial and other permanent alopecias.

    Science.gov (United States)

    Finner, Andreas M; Otberg, Nina; Shapiro, Jerry

    2008-01-01

    Various nonfollicular scalp conditions can cause secondary scarring or permanent alopecia. Possible causes are congenital defects, trauma, inflammatory conditions, infections, and neoplasms (rarely drugs). Associated signs and symptoms and other diagnostic procedures such as histopathology may aid in the diagnosis. Detection of the underlying disorder may be difficult in end-stage lesions. Treatment is specific for active conditions. Surgery and hair transplantation are options for localized scars.

  14. Alopecia Areata Associated with Abacavir Therapy

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    Kim, Hee-Sung; Shin, Hyoung-Shik

    2014-01-01

    Abacavir is a nucleoside reverse-transcriptase inhibitor that has been approved for use in combination with other retroviral agents in the treatment of HIV infection. Common adverse reactions include headache, fatigue, nausea, and rash. A fatal hypersensitivity reaction may occur in 5% of patients receiving abacavir; therefore, screening for HLA-B5701 should be performed before starting abacavir. Alopecia areata (AA) is infrequently reported in HIV-infected patients. Certain underlying condit...

  15. Radiation-Induced Alopecia after Endovascular Embolization under Fluoroscopy

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    Vipawee Ounsakul

    2016-01-01

    Full Text Available Radiation-induced alopecia after fluoroscopically guided procedures is becoming more common due to an increasing use of endovascular procedures. It is characterized by geometric shapes of nonscarring alopecia related to the area of radiation. We report a case of a 46-year-old man presenting with asymptomatic, sharply demarcated rectangular, nonscarring alopecic patch on the occipital scalp following cerebral angiography with fistula embolization under fluoroscopy. His presentations were compatible with radiation-induced alopecia. Herein, we also report a novel scalp dermoscopic finding of blue-grey dots in a target pattern around yellow dots and follicles, which we detected in the lesion of radiation-induced alopecia.

  16. Diphenylcyclopropenone-Induced Vitiligo in a Patient with Alopecia Universalis

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    Hassan Riad

    2013-08-01

    Full Text Available Alopecia areata and vitiligo are autoimmune diseases, both associated with multiple autoimmune comorbidities. Many studies show colocalization of these diseases at the same anatomical site. Here, we have a case where both disorders were reported to present in the same patient. Diphenylcyclopropenone (diphencyprone, DCP is used in the treatment of alopecia areata and may induce vitiligo in some patients. We report on one case of vitiligo that was induced by DCP during therapy for alopecia universalis. Alopecia areata and vitiligo share many susceptibility genes. Follicular melanocyte destruction may represent the link between the two diseases.

  17. Dermatoglyphics in Alopecia Areata - A Case Control Study

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    A. Bhakta

    2012-10-01

    Full Text Available Alopecia areata subjects are characterized by asymptomatic, circular or oval smooth patches of complete loss of hair on scalp, the beard or elsewhere. In the present study alopecia areata subjects were examined in terms of dermatoglyphic characteristics and compared with that of controls. Frequency of loops was decreased in alopecia areata but in case of whorls and arches (not in male subjects increased numbers are recorded than their counterpart. On palm, a-b ridge count (a-b RC was found to be increased in both sexes of alopecia areata(statistically significant increase in alopecia areata Female while atd angles were reduced in females. In male subjects of alopecia areata, true palmar pattern (TPP was increased in both hypothenar and left interdigital-2 (ID2 areas while in females, TPP were increased in both inter digital area-2 and 3 and left ID4 areas. TPP were reduced in left thenar (Lt. Th.,Lt. ID1, ID3, ID4, Rt. ID2, ID3 and ID4 areas of alopecia areata males and both right and left thenar and hypothenar and right ID4 areas of females. This study reveals deviation in the form of reduction of number of loops and increase in number of whorls and arches in alopecia subjects. Deviation is also observed in a-b ridge count and atd angle. These can be considered as quite useful as a supportive investigation and to some extent knowing the prediction for alopecia areata.

  18. Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata - part I Desafio clínico e histológico no diagnóstico diferencial de alopecia difusa: alopecia androgenética, eflúvio telógeno e alopecia areata - parte I

    OpenAIRE

    2012-01-01

    Diffuse androgenetic alopecia (female pattern hair loss), telogen effluvium, and diffuse alopecia areata may have similar clinical manifestations. Subtle details on physical examination and dermoscopy of the scalp may help to identify those disorders. The authors present a practical discussion on how to approach the patient with diffuse alopecia, considering clinical history, physical examination, and dermoscopic findings. If the diagnosis remains unclear after a careful analysis of the clini...

  19. Alopecia areata and narcolepsy: a tale of obscure autoimmunity.

    Science.gov (United States)

    Nigam, Gaurav; Pathak, Charu; Riaz, Muhammad

    2016-04-08

    Alopecia areata is an autoimmune dermatological disorder characterised by loss of hair in one or more discrete patches over the scalp. It has been linked to multiple disorders having an autoimmune origin. Like many autoimmune disorders it tends to be more common in females. To date, only five cases have been reported where alopecia has been associated with narcolepsy. Male gender is less commonly affected by alopecia areata. No case of alopecia areata in males has been associated with narcolepsy to the best of our knowledge. The current case represents the first ever-reported case of alopecia areata in a male patient with narcolepsy type 1. This coexistence is most likely the manifestation of a common underlying pathoimmunological mechanism that has not been completely understood, rather than a random association.

  20. Etiology of cicatricial alopecias: a basic science point of view.

    Science.gov (United States)

    McElwee, Kevin J

    2008-01-01

    This article presents a short summary of our current knowledge of cicatricial alopecia disease pathogenesis and the hypothetical disease mechanisms that may be involved in scarring alopecia development. Several forms of scarring alopecia likely involve targeted cytotoxic action against hair follicle cells mediated by a folliculocentric inflammation. However, the specific nature of the inflammatory interference in hair follicle growth is open to question. A popular hypothesis of lymphocyte-mediated scarring alopecia development involves autoimmune targeting of hair follicle-specific self-antigens, although there is no direct evidence in support of such a view. Alternative hypotheses focus on defects in sebaceous gland function, destruction of hair follicle stem cells, and interference in the communication between hair follicle mesenchyme and epithelium. Many questions arise from these hypotheses, and addressing them with a systematic research approach may enable significant advances in understanding cicatricial alopecia etiology.

  1. Central centrifugal cicatricial alopecia: challenges and solutions.

    Science.gov (United States)

    Herskovitz, Ingrid; Miteva, Mariya

    2016-01-01

    Central centrifugal cicatricial alopecia (CCCA) is the most common scarring alopecia among African American women. Data about epidemiology, etiology, genetic inheritance, and management are scarce and come from individual reports or small series. CCCA has been associated with hot combing and traumatic hair styling for years; however, studies fail to confirm it as the sole etiologic factor. It has been shown in a small series that CCCA can be inherited in an autosomal dominant fashion, with a partial penetrance and a strong modifying effect of hairstyling and sex. CCCA presents clinically as a central area of progressive irreversible hair loss that expands to the periphery. A patchy form has also been described. Dermoscopy is helpful to identify the optimal site for the biopsy, which establishes the diagnosis. Well-designed randomized controlled trials are needed to discover the optimal management. At this point, patients are advised to avoid traction and chemical treatments; topical and intralesional steroids, calcineurin inhibitors, and minoxidil can be helpful in halting the progression.

  2. Nail lichen planus in a patient with alopecia totalis.

    Science.gov (United States)

    Ginsberg, Brian A; Yost, John Montgomery; Lewin, Jesse; Hale, Christopher S; Meehan, Shane A; Carucci, John A; Ramachandran, Sarika

    2014-12-16

    A 67-year-old man with a three-year history of non-scarring alopecia that progressed to alopecia totalis despite intralesional glucocorticoid injections is presented. He developed 20-nail dystrophy that was recalcitrant to antifungal and anti-inflammatory treatments. Biopsy of the nail matrix showed histopathologic features of lichen planus. Alopecia totalis and isolated lichen planus of the nails are uncommon subtypes of common dermatologic disorders. Rarely reported concurrently, we provide a review of the literature of their association, which is most likely attributed to their autoimmune pathogeneses.

  3. Androgenic alopecia in women: an Indian perspective.

    Science.gov (United States)

    Sehgal, Virendra N; Srivastava, Govind; Aggarwal, Ashok K; Midha, Reshmi

    2013-01-01

    The authors sought to investigate androgenic alopecia (AA) utilizing clinical and investigative procedures to establish the pattern of AA in the Indian subcontinent. A total of 35 consecutive women presenting with AA were included. After obtaining informed consent, a detailed history/examination, hair pull test, trichogram, and a scalp biopsy were performed in patients. AA classification was attempted across Ludwig and Norwood guidelines. Of 35 women, 16 had grade I, 10 had grade II, and 1 had grade III Ludwig classification. In addition, 6 other women had Christmas tree baldness: 1 each of fronto-parietal and male pattern baldness. Several investigations including hormonal profile were inconclusive; however, hair pull test and trichogram may be helpful in understanding the sequence in AA in women. AA has infrequently been reported, particularly India and in Asia in general.

  4. Alopecia areata: pathogenesis and potential for therapy.

    Science.gov (United States)

    Lu, Wei; Shapiro, Jerry; Yu, Mei; Barekatain, Armin; Lo, Blanche; Finner, Andreas; McElwee, Kevin

    2006-06-20

    Although the complete picture for alopecia areata (AA) pathogenesis has yet to be determined, recent research has made much progress in our understanding of the disease mechanism. Numerous circumstantial evidence supports the notion that AA is fundamentally a disease mediated by inflammatory cells and may be autoimmune in nature. Recent research has shown the hair-loss phenotype is precipitated predominantly by CD8+ lymphocytes, but the disease mechanism is driven by CD4+ lymphocytes. Although genetic susceptibility is a key contributor to disease development, disease onset and phenotypic presentation are probably modified by complex environmental interplay. On the basis of our current understanding of AA disease pathogenesis, several experimental and theoretical therapeutic approaches might be possible. However, the pathogenetic disease mechanism is particularly robust and the development of a cure for AA will be a significant challenge.

  5. TINEA CAPITIS– SIGNIFICANCE OF TIMELY TREATMENT TO PREVENT SCARRING ALOPECIA

    Directory of Open Access Journals (Sweden)

    Sandrina Carvalho

    2016-09-01

    Conclusion: The treatment of tinea capitis is simple and effective. Timely identification and treatment are essential to prevent the formation of a cicatricial alopecia, often disturbing for the patient.

  6. Paraneoplastic alopecia associated with hepatocellular carcinoma in a cat.

    Science.gov (United States)

    Marconato, Laura; Albanese, Francesco; Viacava, Paolo; Marchetti, Veronica; Abramo, Francesca

    2007-08-01

    A 15-year-old spayed female domestic shorthair cat presented with alopecia associated with hepatocellular carcinoma. Clinical signs, which had commenced 6 months previously, included loss of appetite, loss of weight, and depression. As reported by the owner, the cat developed alopecia a week before referral. The hair loss was localized to the ventral aspect of the thorax and abdomen, medial aspect of front and hind limbs, and ventral aspect of the tail, and was associated with histological features consistent with paraneoplastic alopecia. At necropsy, multiple hepatic nodules were observed, and subsequent histopathological investigation showed cords and sheets of hepatocyte-like neoplastic cells positive for the hepatocyte marker (Hep Par 1), thereby demonstrating the hepatocellular origin of the tumour, which was diagnosed as a hepatocellular carcinoma. This is the first report of feline paraneoplastic alopecia associated with hepatocellular carcinoma confirmed by the Hep Par 1 marker.

  7. Frontal Fibrosing Alopecia: Role of Dermoscopy in Differential Diagnosis

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    P. Rubegni

    2010-04-01

    Full Text Available Frontal fibrosing alopecia (FFA is more common in postmenopausal women, but it can occur in younger women. Some authors consider FFA to be a distinct frontal variant of lichen planopilaris. From a clinical point of view, this relatively uncommon condition is characterized by progressive frontotemporal recession due to inflammatory destruction of hair follicles. Dermoscopy can be very useful, as the differential diagnosis between traction alopecia, alopecia areata, FFA and cicatricial marginal alopecia may be difficult. It is not clear whether or not treatment alters the natural history of the disease – the disease stabilized with time in most of the patients with or without continuing treatment. Here we report a case of a 50-year-old woman with FFA and discuss the relevance of dermoscopy in the differential diagnosis of this disease.

  8. Frontal Fibrosing Alopecia: Role of Dermoscopy in Differential Diagnosis

    Science.gov (United States)

    Rubegni, P.; Mandato, F.; Fimiani, M.

    2010-01-01

    Frontal fibrosing alopecia (FFA) is more common in postmenopausal women, but it can occur in younger women. Some authors consider FFA to be a distinct frontal variant of lichen planopilaris. From a clinical point of view, this relatively uncommon condition is characterized by progressive frontotemporal recession due to inflammatory destruction of hair follicles. Dermoscopy can be very useful, as the differential diagnosis between traction alopecia, alopecia areata, FFA and cicatricial marginal alopecia may be difficult. It is not clear whether or not treatment alters the natural history of the disease - the disease stabilized with time in most of the patients with or without continuing treatment. Here we report a case of a 50-year-old woman with FFA and discuss the relevance of dermoscopy in the differential diagnosis of this disease. PMID:21173926

  9. Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata - part I Desafio clínico e histológico no diagnóstico diferencial de alopecia difusa: alopecia androgenética, eflúvio telógeno e alopecia areata - parte I

    Directory of Open Access Journals (Sweden)

    Betina Werner

    2012-10-01

    Full Text Available Diffuse androgenetic alopecia (female pattern hair loss, telogen effluvium, and diffuse alopecia areata may have similar clinical manifestations. Subtle details on physical examination and dermoscopy of the scalp may help to identify those disorders. The authors present a practical discussion on how to approach the patient with diffuse alopecia, considering clinical history, physical examination, and dermoscopic findings. If the diagnosis remains unclear after a careful analysis of the clinical signs, a scalp biopsy may help to distinguish between the three diseases. In this first part of our study, an objective review of female androgenetic alopecia is presented and the most important histological changes are discussed.Alopecia androgenética difusa (alopecia de padrão feminino, eflúvio telógeno e alopecia areata difusa podem ter apresentações clínicas similares. Detalhes sutis no exame físico e na dermatoscopia do couro cabeludo podem ser úteis no diagnóstico diferencial e interferir na conduta e resultados terapêuticos. Os autores apresentam uma discussão prática de como abordar a paciente com alopecia difusa considerando dados da história clínica, exame físico e dermatoscópico. Quando a dúvida persistir após uma análise cuidadosa dos aspectos clínicos, uma biópsia de couro cabeludo pode permitir a distinção entre as três doenças. Nesta primeira parte, a alopecia androgenética de padrão feminino é abordada em maior detalhe e se faz uma revisão objetiva das principais alterações microscópicas observadas.

  10. Scalp psoriasis associated with central centrifugal cicatricial alopecia

    Directory of Open Access Journals (Sweden)

    Krista N. Larson

    2017-01-01

    Full Text Available Scalp psoriasis is a very common dermatological condition with a variety of presentations, but only rarely presents as severe alopecia. We present a case of a 50-year-old female with many years of recalcitrant hair loss that was thought to be secondary to central centrifugal cicatricial alopecia which was later diagnosed as psoriasis. This case highlights an interesting presentation and rare complication of a common disease.

  11. Psoriatic Alopecia in a Patient with Systemic Lupus Erythematosus

    OpenAIRE

    Wimolsiri Iamsumang; Tueboon Sriphojanart; Poonkiat Suchonwanit

    2017-01-01

    Psoriasis is a chronic, recurrent, and relatively common inflammatory dermatologic condition, which demonstrates various clinical manifestations including hair loss. It was once believed that alopecia was not a presentation of scalp psoriasis, but it is now widely accepted that psoriatic alopecia exists. Although the majority of patients get hair regrowth, it can potentially lead to permanent hair loss. Herein, we report a case of 26-year-old female patient with systemic lupus erythematosus w...

  12. Alopecia: Possible Causes and Treatments, Particularly in Captive Nonhuman Primates

    OpenAIRE

    2009-01-01

    Alopecia (hair loss) occurs in some nonhuman primates housed in captivity and is of concern to colony managers and veterinarians. Here we review the characteristics, potential causes, and treatments for this condition. Although we focus on nonhuman primates, relevant research on other mammalian species is discussed also, due to the relative paucity of studies on alopecia in the primate literature. We first discuss the cycle of hair growth and explain how this cycle can be disrupted to produce...

  13. Alopecia: possible causes and treatments, particularly in captive nonhuman primates.

    Science.gov (United States)

    Novak, Melinda A; Meyer, Jerrold S

    2009-02-01

    Alopecia (hair loss) occurs in some nonhuman primates housed in captivity and is of concern to colony managers and veterinarians. Here we review the characteristics, potential causes, and treatments for this condition. Although we focus on nonhuman primates, relevant research on other mammalian species is discussed also, due to the relative paucity of studies on alopecia in the primate literature. We first discuss the cycle of hair growth and explain how this cycle can be disrupted to produce alopecia. Numerous factors may be related to hair loss and range from naturally occurring processes (for example, seasonality, aging) to various biologic dysfunctions, including vitamin and mineral imbalances, endocrine disorders, immunologic diseases, and genetic mutations. We also address bacterial and fungal infections, infestation by parasites, and atopic dermatitis as possible causes of alopecia. Finally, we examine the role of psychogenic factors, such as stress. Depending on the presumed cause of the hair loss, various treatment strategies can be pursued. Alopecia in nonhuman primates is a multifaceted disorder with many potential sources. For this reason, appropriate testing for various disease conditions should be completed before alopecia is considered to be related to stress.

  14. Perifollicular fibrosis: pathogenetic role in androgenetic alopecia.

    Science.gov (United States)

    Yoo, Hyeon Gyeong; Kim, Jin Sook; Lee, Se Rah; Pyo, Hyun Keol; Moon, Hyung In; Lee, Jong Hee; Kwon, Oh Sang; Chung, Jin Ho; Kim, Kyu Han; Eun, Hee Chul; Cho, Kwang Hyun

    2006-06-01

    Androgenetic alopecia (AGA) is a dihydrotestosterone (DHT)-mediated process, characterized by continuous miniaturization of androgen reactive hair follicles and accompanied by perifollicular fibrosis of follicular units in histological examination. Testosterone (T: 10(-9)-10(-7) M) treatment increased the expression of type I procollagen at mRNA and protein level. Pretreatment of finasteride (10(-8) M) inhibited the T-induced type I procollagen expression at mRNA (40.2%) and protein levels (24.9%). T treatment increased the expression of transforming growth factor-beta 1 (TGF-beta1) at protein levels by 81.9% in the human scalp dermal fibroblasts (DFs). Pretreatment of finasteride decreased the expression of TGF-beta1 protein induced by an average of T (30.4%). The type I procollagen expression after pretreatment of neutralizing TGF-beta1 antibody (10 microg/ml) was inhibited by an average of 54.3%. Our findings suggest that T-induced TGF-beta1 and type I procollagen expression may contribute to the development of perifollicular fibrosis in the AGA, and the inhibitory effects on T-induced procollagen and TGF-beta1 expression may explain another possible mechanism how finasteride works in AGA.

  15. Alopecia areata associated with abacavir therapy.

    Science.gov (United States)

    Kim, Hee-Sung; Shin, Hyoung-Shik

    2014-06-01

    Abacavir is a nucleoside reverse-transcriptase inhibitor that has been approved for use in combination with other retroviral agents in the treatment of HIV infection. Common adverse reactions include headache, fatigue, nausea, and rash. A fatal hypersensitivity reaction may occur in 5% of patients receiving abacavir; therefore, screening for HLA-B5701 should be performed before starting abacavir. Alopecia areata (AA) is infrequently reported in HIV-infected patients. Certain underlying conditions have been associated with AA, including a decreased CD4:CD8 ratio related to the progression of HIV infection, some opportunistic infections, and syphilis. Several antiretroviral drugs, such as zidovudine, indinavir, indinavir/ritonavir, lopinavir/ritonavir, and atazanavir/ritonavir have been implicated in the development of AA. At present, the occurrence of AA has not been associated with abacavir use. We cannot exclude that the use of abacavir and the development of AA could be coincidental. Nevertheless, patients given abacavir should be monitored for hair loss and the drug discontinued promptly if such signs appear.

  16. Chemotherapy-induced alopecia: advice and support for hair loss.

    Science.gov (United States)

    Roe, Helen

    This article provides insight into the growth cycle of a hair follicle and the potential impact chemotherapy agents can have on this process, which often results in hair loss (alopecia). It explores the psychological consequences of chemotherapy-induced alopecia for an individual as a result of the perceptions of others as well as an individual's perception of his or her self-image. Despite the development of various forms of scalp cooling, chemotherapy-induced alopecia remains a major side effect for patients receiving chemotherapy; however, there have been improvements in wig provision and changing public opinion relating to baldness. Although chemotherapy-induced alopecia affects both males and females and all age groups, this article focuses on the potential impact for patients receiving chemotherapy as a form of treatment for breast cancer. As professionals we need to understand the social significance of hair in relation to a person's outward presentation and social interactions, along with the possible psychological implications of a person losing his or her bodily hair, and not just the head hair. We must aim to minimize the distress alopecia can cause by: ensuring we provide patients with up-to-date verbal and written information to enable them to prepare for losing their hair; helping them to preserve their self-image and minimize the psychological consequences of hair loss while receiving chemotherapy; and preparing them for their hair re-growth following completion of chemotherapy.

  17. EFECTIVITY MINOXIDIL AS A TREATMENT OF ALOPECIA AREATA

    Directory of Open Access Journals (Sweden)

    Wayan Evie Frida Yustin

    2014-01-01

    Full Text Available Alopecia areata is hair loss with patchy formation, the most common cause of alopecia nonscarring. Occurred in 1,7 % of Americans aged 50 years. Canoccurs in both sexes, all races and any age. Genetic and immunological factorsplay an important role as a cause of Alopecia areata. The clinical features alopecia areata are round or oval lesions, total baldness, smoothness on the scalpor other parts of the body that has hair. Minoxidil is one of the effective therapyfor Alopecia areata. Known for more than 30 years of minoxidil to stimulate hairgrowth. Minoxidil works on hair follicles, opening the potassium channels, andhave vascular effects that can increase blood flow to hair. Histological studiesshowed that minoxidil therapy may increase the proportion hair follicles in anagenphase and decrease hair follicles at telogen phase. Minoxidil through sulphatmetabolites can open potassium channels, the opening potassium channels canincrease the hair follicles growth. The study of the effects minoxidil on humanepidermal keratinocytes and hair follicles with different culture conditions andmarkers proliferation, found that minoxidil with micro molar concentration canstimulate proliferation both type of cells and all culture condition, whereasminoxidil with milimolar concentration will inhibit cell growth. In addition,several studies have also reported an association minoxidil to vascular effect andstimulating VEGF can promote the increase hair follicle

  18. Clinical features of primary cicatricial alopecia in Chinese patients

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    Shiling Qi

    2014-01-01

    Full Text Available Background: There have been few reports on primary cicatricial alopecias (PCR especially from Asia (PCA. Aims: To study the clinical, pathological and dermoscopic characteristics of PCA among Chinese patients. Methods: A retrospective analysis of the clinical data of 59 patients with PCA was conducted and the dermoscopic, pathological, treatment and prognosis characteristics analyzed. Fisher′s Chi-square exact test, Kruskal-Wallis and Spearman rank correlation test were performed. Results: The ratio of neutrophilic to lymphocytic cicatricial alopecias was about 1.3:1 in this group. The most frequent disorder was folliculitis decalvans. Follicular openings were absent on dermoscopy in all cases except alopecia mucinosa. Patulous follicular openings were characterisitc of alopecia mucinosa. After treatment, an increase in short vellus hairs was the earliest feature, while telangiectasia, epidermal scale, follicular hyperkeratosis, pustules and hair diameter diversity gradually decreased or even disappeared. Improvement in the areas of hair loss after treatment was seen more often in discoid lupus erythematosus, folliculitis decalvans and dissecting cellulitis than in patients with classic pseudopelade of Brocq. Nine patients (13.6% relapsed after cessation of therapy. Female patients needed longer treatment times. Long duration, large areas of hair loss and shorter treatment courses were the major factors in relapses. Conclusions: Dermatoscopy provides a rapid, practical and useful aid for the diagnosis of PCA and also to assess disease activity. Patulous follicular openings are a specific dermoscopic sign of alopecia mucinosa. Lichen planopilaris is less common in China than in the West.

  19. Feline paraneoplastic alopecia associated with metastasising intestinal carcinoma

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    Lisa-Maria Grandt

    2015-12-01

    Full Text Available Case summary A 10-year-old male neutered British Shorthair cat was presented with a 6 month history of lethargy, weight loss and alopecia. Clinical examination revealed widespread alopecia of the ventral abdomen and hindlimbs. The skin in these areas was smooth and shiny and hairs could be easily epilated. Spontaneous pruritus was observed. Cytological examination of superficial impression smears showed a severe Malassezia species dermatitis and pyoderma. Ectoparasites could not be detected and no sign of dermatophytosis was visible in trichograms and Wood’s lamp analysis. Abdominal ultrasound found a focally thickened wall of the large intestine and multiple nodules in the liver. Fine-needle aspirates from lymph nodes, liver and altered colonic wall were consistent with an undifferentiated malignant neoplasia. The cat was euthanased at the owners’ request, owing to potential neoplasia with metastatic spread. At necropsy a metastasising carcinoma of the colonic wall was found, as well as a paraneoplastic alopecia. Relevance and novel information Feline paraneoplastic alopecia has been reported in association with pancreatic carcinoma, bile duct carcinoma and hepatocellular carcinoma, as well as with neuroendocrine pancreatic carcinoma and hepatosplenic plasma cell tumour. This is the first reported case of feline paraneoplastic alopecia associated with a colon carcinoma.

  20. Bilateral Temporal Triangular Alopecia Associated with Phakomatosis Pigmentovascularis Type IV Successfully Treated with Follicular Unit Transplantation

    Directory of Open Access Journals (Sweden)

    Robin Unger

    2011-01-01

    Full Text Available Temporal triangular alopecia (TTA, also known as congenital triangular alopecia, is a nonscarring, noninflammatroy, circumscribed form of alopecia. TTA has been associated with several disorders, such as Phakomatosis Pigmentovascularis. Hair restoration surgery using follicular unit transplantation has been a successful treatment modality for TTA. Herein we report such a success that was sustained for over six years.

  1. Hereditary vitamin D-resistant rickets presenting as alopecia.

    Science.gov (United States)

    Casey, Genevieve; McPherson, Tess; Kini, Usha; Ryan, Fiona; Taibjee, Saleem M; Moss, Celia; Burge, Susan

    2014-01-01

    Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene. We report the case of an infant presenting with alopecia, growth failure, and gross motor developmental delay. Serum biochemistry and skeletal survey were consistent with rickets. After a poor response to standard treatment, genetic testing confirmed a c.147-2A>T novel mutation in the VDR gene consistent with HVDRR. It is important for dermatologists and pediatricians to recognize alopecia as a presenting sign of HVDRR because appropriate treatment leads to better growth and development of the child.

  2. Dr. Yu Wenqiu's Experience in Treating Seborrheic Alopecia

    Institute of Scientific and Technical Information of China (English)

    Ding Xiongfei

    2007-01-01

    @@ In China, the occurrence of seborrheic alopecia is on the rise. Chief physician Yu Wenqiu, by combining the rich experience obtained by physicians at all times with his own long-term clinical practice, has developed Shenying Yihao Shengfa Tang and Shenying Erhao Shengfa Tang(神应Ⅰ号生发汤Decoction for Hair Growth No.Ⅰand 神应Ⅱ号生发汤 Decoction for Hair Growth No. Ⅱ), which have yielded very good therapeutic effects for seborrheic alopecia. Following is an introduction to his experience in this aspect.

  3. Late-onset alopecia areata: descriptive analysis of 30 cases*

    Science.gov (United States)

    Lazzarini, Rosana; Oliari, Camila Bilac; Erthal, Ana Luisa Nasser

    2016-01-01

    Alopecia areata is an autoimmune disease characterized by non-scaring hair loss. The onset in over 50-year-old patients is rare and has barely been studied. Cases of this disease have been retrospectively analyzed – according to clinical forms, extension, and associated diseases – to assess alopecia areata characteristics in a group of patients whose disease onset was after the age of 50. 30 patients were studied; a few of them presented with autoimmune-related diseases or family history. The disease onset after the age of 50 seems to have different characteristics from those found in young people. PMID:28099618

  4. A case of lenflunomide-induced alopecia areata

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    Gürol Açıkgöz

    2015-03-01

    Full Text Available Leflunomide is an immunomodulatory drug widely used in the treatment of inflammatory arthritis especially in rheumatoid arthritis and psoriatic arthritis. The common side effects of leflunomide are hepatopathy, hypertension, various gastrointestinal complaints and transient hair loss, which were mild and reversible. Although leflunomide is associated with transient hair loss, leflunomide induced alopecia areata was reported previously only in one case. In this case report, we present a 38-year-old male patient who suffered from alopecia areata after leflunomide therapy.

  5. Reflectance confocal microscopy for scarring and non-scarring alopecia real-time assessment.

    Science.gov (United States)

    Ardigò, Marco; Agozzino, Marina; Franceschini, Chiara; Donadio, Carlo; Abraham, Leonardo Spagnol; Barbieri, Luca; Sperduti, Isabella; Berardesca, Enzo; González, Salvador

    2016-07-01

    Clinical management of alopecia represents one of the major issues in dermatology. Scalp biopsies are not easily accepted because of the high bleeding and sensitive anatomical area. Trichoscopy is routinely used for diagnosis of alopecia, but in several cases lack to provide sufficient information on the status of the disease. Recently, reflectance confocal microscopy demonstrated its usefulness for the evaluation of several inflammatory skin condition and preliminary reports about alopecia have been proposed in the literature. The aim was to identify the confocal features characterizing scarring and non-scarring alopecia. Reflectance confocal microscopy from 86 patients affected by scarring (28 lichen planopilaris and 9 lupus erythematosus) and non-scarring alopecia (30 androgenic alopecia and 19 alopecia areata), were retrospectively, blinded evaluated. Good concordance between different readers on the confocal criteria has been assessed. Statistical significant features, specific for scarring alopecia and non-scarring alopecia have been identified. In this study, data on reflectance confocal microscopy features useful for the differential diagnosis between scarring and non-scarring alopecia have been identified. Further studies focusing on the use of this non-invasive technique in the therapeutic follow-up and distinction of sub-entities of alopecia are still required.

  6. Guidelines on the use of finasteride in androgenetic alopecia

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    Venkataram Mysore

    2016-01-01

    Full Text Available Background: Finasteride is a widely used drug in dermatology for the treatment of androgenetic alopecia. There are many reports of associated sexual side effects. This article reviews the use of once-daily 1 mg finasteride in androgenetic alopecia and its associated sexual adverse effects. Methods: A literature search was performed to collect data on the use of finasteride in male pattern baldness. Relevant literature published till March 2014 was obtained from MEDLINE, EMBASE, CINAHL, Cochrane registers and LILACS. The keywords "finasteride", "male pattern baldness" and "androgenetic alopecia" were used for literature search. Similarly, a search was done for finasteride in female pattern hair loss with keywords "female pattern baldness", "finasteride" and "female pattern alopecia". All systematic reviews, meta-analyses, national guidelines, randomized controlled trials, prospective open label studies and retrospective case series in the English literature were reviewed. Results: Two hundred sixty two studies were evaluated, twelve of which fulfilled the inclusion criteria. Conclusions and Recommendations: Current evidence on the safety of finasteride indicates that it is safe but there is growing concern about its sexual side effects. In view of this, proper information should be provided to patients prior to starting treatment (Level of recommendation 1+, Grade of recommendation B. The reported sexual side effects are few and reverse with stoppage of the drug (Grade of recommendation B but further studies are required.

  7. Psychological effect, pathophysiology, and management of androgenetic alopecia in men.

    Science.gov (United States)

    Stough, Dow; Stenn, Kurt; Haber, Robert; Parsley, William M; Vogel, James E; Whiting, David A; Washenik, Ken

    2005-10-01

    Androgenetic alopecia In men, or male pattern baldness, is recognized increasingly as a physically and psychologically harmful medical condition that can be managed effectively by generalist clinicians. This article discusses the clinical manifestations, epidemiology, physical and psychosocial importance, pathophysiology, diagnosis, and management of androgenetic alopecia in men. Androgenetic alopecia affects at least half of white men by the age of 50 years. Although androgenetic alopecia does not appear to cause direct physical harm, hair loss can result in physical harm because hair protects against sunburn, cold, mechanical injury, and ultraviolet light. Hair loss also can psychologically affect the balding individual and can Influence others' perceptions of him. A progressive condition, male pattern baldness is known to depend on the presence of the androgen dihydrotestosterone and on a genetic predisposition for this condition, but its pathophysiology has not been elucidated fully. Pharmacotherapy, hair transplantation, and cosmetic aids have been used to manage male pattern baldness. Two US Food and Drug Administration-approved hair-loss pharmacotherapies-the potassium channel opener minoxidil and the dihydrotestosterone synthesis inhibitor finasteride--are safe and effective for controlling male pattern baldness with long-term daily use. Regardless of which treatment modality is chosen for male pattern baldness, defining and addressing the patient's expectations regarding therapy are paramount in determining outcome.

  8. HLA-DP antigens in patients with alopecia areata

    DEFF Research Database (Denmark)

    Ødum, Niels; Morling, N; Georgsen, J;

    1990-01-01

    The distribution of HLA-DP antigens were studied in 41 patients with alopecia areata (AA) and 188 ethnically matched controls. An increase of DR4 and possibly DR5 in 24 of these patients has previously been reported. HLA-DP typing for DPw1 through w6 and the local specificity, CDP HEI, was perfor...

  9. Alopecia: manifestação cutânea rara de sarcoidose Alopecia: an uncommon cutaneous manifestation of sarcoidosis

    Directory of Open Access Journals (Sweden)

    Fabiane Mulinari Brenner

    2008-10-01

    Full Text Available A sarcoidose é doença granulomatosa multissistêmica que geralmente compromete o trato respiratório e os linfonodos hilares. A pele é comumente afetada, mas raramente o couro cabeludo. Dois casos de sarcoidose com lesões no couro cabeludo são relatados: o primeiro, em paciente negra apresentando áreas de alopecia no couro cabeludo associada a outras lesões cutâneas; e o segundo, em paciente branca, portadora de sarcoidose pulmonar, com alopecia como manifestação cutânea isolada. A sarcoidose de couro cabeludo merece especial atenção, pois nos pacientes com essa forma de lesão cutânea existe alta incidência de acometimento sistêmico.Sarcoidosis is a multi-system granulomatous disease that generally affects the respiratory tract and hilar lymph nodes. The skin is also commonly involved, although cutaneous sarcoidosis on the scalp is rare. Two cases of scalp sarcoidosis are reported: the first presented with patchy alopecia, cutaneous sarcoidosis and also systemic disease in a black patient; the second case is related to an uncommon presentation with alopecia as the single cutaneous manifestation in a Caucasian patient with pulmonary sarcoidosis. Scalp sarcoidosis deserves special attention because there is a high incidence of other systemic lesions with this cutaneous manifestation, thus a careful investigation should be performed in these patients.

  10. A non-invasive study of alopecia in Japanese macaques Macaca fuscata

    Institute of Scientific and Technical Information of China (English)

    Peng ZHANG

    2011-01-01

    This article provides information on the phenomenon of alopecia in Japanese macaques, Macaca fuscata, in various environments and proposes a 3-step scoring system for a quantitative assessment of hair loss. Results suggest that alopecia is commonly observed in Japanese macaques, with 20.5% of individuals showing head alopecia and 4.7% showing back alopecia across eight study groups. Alopecia was more commonly observed in adult females (30.8% individuals showing head alopecia and 15.3% showing back alopecia) than in other age-sex classes. Seasonal variation of back alopecia was noted, in particular, individuals with patchy back hair were more frequently observed in winter than in summer. Seasonal variation was not observed in head hair. The distribution of alopecia was also different among study groups. The wild population generally had better hair condition than provisioned populations and captive populations. The present study used a non-invasive alopecia scoring system which can be a useful, rapid and non-invasive tool to monitor animal health and well-being at a population level.

  11. Linear non scarring alopecia of the scalp: A rare manifestation of lupus panniculitis

    Directory of Open Access Journals (Sweden)

    Sandhyarani Kshetrimayum

    2016-01-01

    Full Text Available Alopecia in a linear pattern is very rare with only a few cases reported in the medical literature. We report a case of linear non scarring alopecia involving the scalp in a 17-year-old boy with a histological diagnosis of lupus panniculitis. We report this case because of its rarity and also the inclusion of this entity as one of the rare differential of non scarring alopecia.

  12. Frontal fibrosing alopecia in association with Sjögren's syndrome: more than a simple coincidence*

    Science.gov (United States)

    Furlan, Karina Colossi; Kakizaki, Priscila; Chartuni, Juliana Cabral Nunes; Valente, Neusa Yuriko Sakai

    2016-01-01

    Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Since then the number of reported cases has increased significantly. Coexistence of frontal fibrosing alopecia and autoimmune disorders - such as discoid erythematosus lupus and Sjögren's syndrome - may suggest a common pathogenic background among the diseases.

  13. A clinical study of topical mucopolysaccharides & polydeoxyribonucleoprotein (Foltene) therapy in alopecia.

    OpenAIRE

    K.S. Lee; Myung, K. B.; Kook, H. I.

    1987-01-01

    We performed clinical trials to evaluate the therapeutic effects of Foltene in patients of the several types of hair fallings. Thirty patients with male pattern baldness, alopecia areata and seborrheic alopecia were included in this study. Foltene was applied every other day for 40 days, and followed by maintenance therapy of twice application a week. The duration of whole therapy was 6 months. We conclude that Foltene is an effective and agent for male pattern baldness, alopecia areata and s...

  14. Linear Non Scarring Alopecia of the Scalp: A Rare Manifestation of Lupus Panniculitis

    Science.gov (United States)

    Kshetrimayum, Sandhyarani; Thokchom, Nandakishore; Hmar, Vanlalhriatpuii

    2016-01-01

    Alopecia in a linear pattern is very rare with only a few cases reported in the medical literature. We report a case of linear non scarring alopecia involving the scalp in a 17-year-old boy with a histological diagnosis of lupus panniculitis. We report this case because of its rarity and also the inclusion of this entity as one of the rare differential of non scarring alopecia. PMID:27688465

  15. Frontal fibrosing alopecia and lichen planopilaris in HLA-identical mother and daughter

    Directory of Open Access Journals (Sweden)

    María Mercedes Otero Rivas

    2015-01-01

    Full Text Available Frontal fibrosing alopecia (FFA is a lymphocyte-mediated scarring alopecia thought to be a variant of lichen planopilaris (LPP. We present a 67-year-old woman with frontal fibrosing alopecia whose daughter was diagnosed to have lichen planopilaris. Both patients had identical human leukocyte antigen (HLA D types, supporting a phenotypical relationship between the two clinical entities. Interestingly, our patient also had of autoimmune chronic atrophic gastritis, a previously unreported association.

  16. Early-onset androgenetic alopecia and endocrine disruptors

    Directory of Open Access Journals (Sweden)

    M. Guarrera

    2011-01-01

    Full Text Available Androgenetic alopecia (AGA is the most common acquired non scarring alopecia in humans caused by androgen hormones in the setting of a genetic predisposition. Usually AGA starts after puberty, but recently it has been observed also in adolescents. Their mean age was 13 years with a slight prevalence in males. The premature AGA may be caused by environmental, alimentary (meat and milk or cosmetics overexposure to sexual hormones or to endocrine disrupters (EDs. EDs are "exogenous substances that interfere with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body causing adverse effects to human health" and they are able bind to the steroid hormone receptors. Early onset AGA may be linked to the well known phenomenon of early puberty caused in some cases by hormones contained in food or by environmental chemicals. Therefore it is likely that the EDs may play a role also in the pathogenesis of early-onset AGA.

  17. FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA

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    Ni Komang Tristiana Dewi

    2013-04-01

    Full Text Available Androgenetic alopecia (AGA is a type of alopecia non sikatrik that most often occur, especially in men. AGA is hereditary baldness and form distinctive patterns. Causes related to AGA estimated serum androgen levels, especially 5-?-dehydrotestosterone (DHT, which can lead to miniaturization of the hair follicle. Finasteride is one of drugs that proven effective in treating hair loss caused by AGA. Finasteride is a 4-azasteroid components that are competitive and specific inhibitor of the enzyme 5-?-reductase type II, an enzyme that converts testosteron into intracellular DHT. By inhibiting the enzyme 5-?-reductase type II, conversion of testosteron to DHT inhibited, thereby causing a significant decrease in serum and tissue DHT concentrations. The use of finasteride 1 mg per day proven to effectively treat AGA in men.  

  18. Effect of minoxidil on hair transplantation in alopecia androgenetica

    Directory of Open Access Journals (Sweden)

    Singh Gurinderjit

    1998-01-01

    Full Text Available Forty patients suffering from androgenetic alopecia were given 3 to 4 sittings of hair transplantation at an interval of 4 to 6 weeks each. Only patients of type III, type III(vertex and type IV baldness were operated. Twenty patients, six of type III, six of type III(vertex and eight of type IV baldness were advised to use minoxidil 2% locally at the recipient area in the dose of 1 ml applied twice daily. Twenty patients of similar types of baldness were advised to just shampoo their hair daily without using topical minoxidil. Percentage of response was compared between the two groups. Minoxidil did not play any role in the percentage of hair survival before and after transplantation in androgenetic alopecia. However in 60percent grafts of patients who had used topical minoxidil, there was no initial postoperative hair shedding.

  19. Molecular signatures define alopecia areata subtypes and transcriptional biomarkers

    Directory of Open Access Journals (Sweden)

    Ali Jabbari

    2016-05-01

    Full Text Available Alopecia areata (AA is an autoimmune disease typified by nonscarring hair loss with a variable clinical course. In this study, we conducted whole genome gene expression analysis of 96 human scalp skin biopsy specimens from AA or normal control subjects. Based on gene expression profiling, samples formed distinct clusters based on the presence or absence of disease as well as disease phenotype (patchy disease compared with alopecia totalis or universalis. Differential gene expression analysis allowed us to robustly demonstrate graded immune activity in samples of increasing phenotypic severity and generate a quantitative gene expression scoring system that classified samples based on interferon and cytotoxic T lymphocyte immune signatures critical for disease pathogenesis.

  20. DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms*

    Science.gov (United States)

    Gaspar, Neide Kalil

    2016-01-01

    The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a negative regulator of fibrotic events induced by TGFβ1. Dehydroepiandrosterone (DHEA) is an immunomodulatory hormone essential for PPAR functions, and is reduced in some processes characterized by fibrosis. Although scarring alopecia characteristically develops in the female biological period in which occurs decreased production of DHEA, there are no data in the literature relating its reduction to fibrogenic process of this condition. This article aims to review the fibrogenic activity of TGFβ1, its control by PPAR and its relation with DHEA in the frontal fibrosing alopecia. PMID:28099600

  1. [Hormonal assessment in a woman with acne and alopecia].

    Science.gov (United States)

    Faure, M; Drapier-Faure, E

    1992-06-01

    Acne, androgenogenetic alopecia, hyperseborrhea and hirsutism may result from hyperandrogenism in women. This may be peripheral "idiopathic" hyperandrogenism due to cutaneous metabolism of steroids, but in some cases hyperandrogenism is due to abnormal production or input of steroids with androgenic activity (hyperplasia, endocrine tumors, cysts, consumption of progestogens or other hormones with androgenic activity, menopause...). An assessment is useful only in cases of acne or alopecia if they are accompanied by other signs of peripheral hyperandrogenism and/or disturbed menstruation. The treatment is based on the administration of an anti-androgen (in France, usually cyproterone acetate), combined with other local or systemic treatments for the problem, depending on the age, dermatological signs and context.

  2. Alopecia areata: Clinical presentation, diagnosis, and unusual cases.

    Science.gov (United States)

    Finner, Andreas M

    2011-01-01

    Alopecia areata (AA) is a nonscarring hair loss disorder with a 2% lifetime risk. Most patients are below 30 years old. Clinical types include patchy AA, AA reticularis, diffuse AA, AA ophiasis, AA sisiapho, and perinevoid AA. Besides scalp and body hair, the eyebrows, eyelashes, and nails can be affected. The disorder may be circumscribed, total (scalp hair loss), and universal (loss of all hairs). Atopy, autoimmune thyroid disease, and vitiligo are more commonly associated. The course of the disease is unpredictable. However, early, long-lasting, and severe cases have a less favorable prognosis. The clinical diagnosis is made by the aspect of hairless patches with a normal skin and preserved follicular ostia. Exclamations mark hairs and a positive pull test signal activity. Dermoscopy may reveal yellow dots. White hairs may be spared; initial regrowth may also be nonpigmented. The differential diagnosis includes trichotillomania, scarring alopecia, and other nonscarring hair loss disorders such as tinea capitis and syphilis.

  3. Ichthyosis follicularis with alopecia and photophobia (IFAP syndrome

    Directory of Open Access Journals (Sweden)

    Rai Vandana

    2006-01-01

    Full Text Available A 12-year-old boy born of a nonconsanguineous marriage presented with dry rough skin and photophobia since birth. His growth and developmental milestones were normal and there was no history of any neurological problem, hearing deficit or scarring around the hair follicles. Cutaneous examination revealed diffuse thinning of scalp hair with loss of eyebrows and eyelashes and a sandpapery texture of the skin all over the body, suggestive of ichthyosis follicularis with alopecia and photophobia syndrome.

  4. Treatment of androgenic disorders in women: acne, hirsutism, and alopecia.

    Science.gov (United States)

    Redmond, G P; Bergfeld, W F

    1990-01-01

    Androgen excess disorders--acne, alopecia, and hirsutism--can be treated effectively with endocrine therapy such as androgen receptor blockers or antagonists, or with androgen suppression. Spironolactone, estrogen, and dexamethasone are considered the most effective approaches to treatment. Whatever the modality, careful planning is key to success, with recognition that response rates vary from patient to patient. A treatment regimen generally continues for at least 2 years.

  5. Alopecia following oral acyclovir for the treatment of herpes simplex keratitis

    Directory of Open Access Journals (Sweden)

    Ashok Sharma

    2014-01-01

    Full Text Available The authors report acyclovir-induced alopecia in a patient treated for herpetic keratouveitis. A 32-years-old female was diagnosed with herpetic keratouveitis. She was placed on prednisolone acetate (1% suspension four times a day, atropine sulfate (1% thrice a day, and oral acyclovir 400 mg twice-daily. Three weeks following oral acylovir, keratouveitis improved, but she developed alopecia without any drug eruptions. Oral acyclovir was discontinued. Three months later, alopecia completely resolved. Alopecia may be considered a possible complication following oral acyclovir.

  6. Alopecia following oral acyclovir for the treatment of herpes simplex keratitis.

    Science.gov (United States)

    Sharma, Ashok; Mohan, Kanwar; Sharma, Rajan; Nirankari, Verinder S

    2014-01-01

    The authors report acyclovir-induced alopecia in a patient treated for herpetic keratouveitis. A 32-years-old female was diagnosed with herpetic keratouveitis. She was placed on prednisolone acetate (1%) suspension four times a day, atropine sulfate (1%) thrice a day, and oral acyclovir 400 mg twice-daily. Three weeks following oral acylovir, keratouveitis improved, but she developed alopecia without any drug eruptions. Oral acyclovir was discontinued. Three months later, alopecia completely resolved. Alopecia may be considered a possible complication following oral acyclovir.

  7. Drug discovery for alopecia: gone today, hair tomorrow

    Science.gov (United States)

    Santos, Zenildo; Avci, Pinar; Hamblin, Michael R

    2015-01-01

    Introduction Hair loss or alopecia affects the majority of the population at some time in their life, and increasingly, sufferers are demanding treatment. Three main types of alopecia (androgenic [AGA], areata [AA] and chemotherapy-induced [CIA]) are very different, and have their own laboratory models and separate drug-discovery efforts. Areas covered In this article, the authors review the biology of hair, hair follicle (HF) cycling, stem cells and signaling pathways. AGA, due to dihydrotesterone, is treated by 5-α reductase inhibitors, androgen receptor blockers and ATP-sensitive potassium channel-openers. AA, which involves attack by CD8+NK group 2D-positive (NKG2D+) T cells, is treated with immunosuppressives, biologics and JAK inhibitors. Meanwhile, CIA is treated by apoptosis inhibitors, cytokines and topical immunotherapy. Expert opinion The desire to treat alopecia with an easy topical preparation is expected to grow with time, particularly with an increasing aging population. The discovery of epidermal stem cells in the HF has given new life to the search for a cure for baldness. Drug discovery efforts are being increasingly centered on these stem cells, boosting the hair cycle and reversing miniaturization of HF. Better understanding of the molecular mechanisms underlying the immune attack in AA will yield new drugs. New discoveries in HF neogenesis and low-level light therapy will undoubtedly have a role to play. PMID:25662177

  8. Alopecia mucinosa responding to antileprosy treatment: Are we missing something?

    Directory of Open Access Journals (Sweden)

    Rajiv Joshi

    2013-01-01

    Full Text Available Three cases with single lesion of Alopecia mucinosa (follicular mucinosis were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence on extended follow-up. Two children, a boy aged 14 years and a girl aged 12 years presented themselves, each, with a single hypopigmented, hypoesthetic patch on the face. Clinically leprosy was suspected, however, skin biopsy from both patients revealed follicular mucinosis as the only pathological finding, without any granulomas. Based on clinical suspicion both were started on multi drug therapy (MDT for leprosy with complete resolution of the lesions. The third case, male, aged 22 years presented with a single erythematous, hypoesthetic plaque on the forehead.This lesion had been diagnosed as follicular mucinosis with folliculo-tropic mycosis fungoides, in the USA. He too responded completely within 3 months with rifampicin, ofloxacin, minocycline (ROM treatment, which was given once monthly for a total of 6 months and remains free of disease since the past 1 year. Follicular mucinosis as the only pathology may be seen in facial lesions of clinically suspected leprosy in children and young adults. Based on histological findings these cannot be diagnosed as leprosy and will be considered as Alopecia mucinosa. These lesions, however, are always single and show rapid and complete response to antileprosy treatment. The authors suggest that in regions endemic for leprosy, such as India, single lesion Alopecia mucinosa on the face in children and young adults should be given antileprosy treatment.

  9. Ichthyosiform mycosis fungoides with alopecia and atypical membranous nephropathy

    Directory of Open Access Journals (Sweden)

    Qiang Zhou

    2011-01-01

    Full Text Available We describe here a rare case of variant of mycosis fungoides (MF: ichthyosiform MF with alopecia and atypical membranous nephropathy. The diagnosis was made based on the following findings: generalized ichthyosis-like eruption, alopecia, enlarged superficial lymph nodes, proteinuria, and hematuria, the histological features of the skin biopsy from both ichthyotic and alopecic lesions with immunohistochemical staining, and the renal biopsy examination with immunofluorescence. The histological examination of ichthyotic and alopecic lesions displayed a predominant infiltration of atypical lymphocytes in the upper dermis with the characteristics of epidermotropism and folliculotropism. Immunohistochemical studies demonstrated that most infiltrated atypical lymphocytes were CD3, CD4, and CD45RO positive, whereas negative for CD5, CD7, CD20, CD30, and CD56. A renal biopsy examination revealed atypical membranous nephropathy with deposition of immunoglobulin G (IgG, IgM, IgA, C1q, and C3. In this case atypical membranous nephropathy was involved, which is very uncommon and has never been presented in the literature to date. Although ichthyosiform MF usually features a relatively favorable course, diffuse alopecia and the renal involvement in this case might indicate aggressive disease and poor prognosis.

  10. Dermoscopic findings in female androgenetic alopecia Achados dermatoscópicos na alopecia androgenética feminina

    Directory of Open Access Journals (Sweden)

    Lya Duarte Ramos

    2012-10-01

    Full Text Available BACKGROUND: Androgenetic alopecia is the most common form of hair loss. It is a clinical entity of relevant interest and presents a significant psychosocial impact as it undermines self-esteem and quality of life in female patients due to the importance of the hair for people's facial balance. OBJECTIVE: The purpose of the present study is to evaluate dermoscopic signs in women clinically diagnosed with androgenetic alopecia. METHOD: Observational study with 34 women between 17 and 68 years old who were diagnosed with androgenetic alopecia. All of them underwent photographic sessions with a 10x magnification dermoscope and a digital camera zoom set to 20x magnification and 40x magnification on the scalp frontal midline. RESULTS: All patients showed miniaturization. A peripilar brown halo was found in 22 patients, honeycomb-like scalp pigmentation was found in 14 and yellow dots in only 1 patient. Recent studies show dermoscopy as the new tool for diagnosis assistance and treatment follow up in scalp disorders. Our study used an ordinary dermoscope and we evaluated several findings reported in the literature with significant clarity and easiness. CONCLUSION: The dermoscope, which is used by dermatologists on a daily basis, is an excellent tool to assist in early diagnosis and assessment of therapeutic response in androgenetic alopecia.FUNDAMENTOS: Alopecia androgenética é forma mais comum de queda de cabelo. Constitui entidade clínica de interesse relevante e acarreta grande impacto psicossocial por comprometer a auto-estima e a qualidade de vida das pacientes. OBJETIVO: Procurar os sinais dermatoscópicos comuns em mulheres com diagnóstico clínico de alopecia androgenética, visando diagnóstico precoce e melhor resposta terapêutica. MÉTODOS: Estudo observacional em 34 mulheres com idades entre 17 e 68 anos, com diagnóstico clínico de alopecia androgenética. Todas pacientes foram avaliadas e submetidas a registros fotográficos com o

  11. EFECTIVITY MINOXIDIL AS A TREATMENT OF ALOPECIA AREATA

    Directory of Open Access Journals (Sweden)

    Wayan Evie Frida Yustin

    2013-07-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE Alopecia areata is hair loss with patchy formation, the most common cause of alopecia nonscarring. Occurred in 1,7 % of Americans aged 50 years. Can occurs in both sexes, all races and any age. Genetic and immunological factors play an important role as a cause of Alopecia areata. The clinical features alopecia areata are round or oval lesions, total baldness, smoothness on the scalp or other parts of the body that has hair. Minoxidil is one of the effective therapy for Alopecia areata. Known for more than 30 years of minoxidil to stimulate hair growth. Minoxidil works on hair follicles, opening the potassium channels, and have vascular effects that can increase blood flow to hair. Histological studies showed that minoxidil therapy may increase the proportion hair follicles in anagen phase and decrease hair follicles at telogen phase. Minoxidil through sulphat metabolites can open potassium channels, the opening potassium channels can increase the hair follicles growth. The study of the effects minoxidil on human epidermal keratinocytes and hair follicles with different culture conditions and markers proliferation, found that minoxidil with micro molar concentration can stimulate proliferation both type of cells and all culture condition, whereas minoxidil with milimolar concentration will inhibit cell growth. In addition, several studies have also reported an association minoxidil to vascular effect and stimulating VEGF can promote the increase hair follicle /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso

  12. Genetics Home Reference: T-cell immunodeficiency, congenital alopecia, and nail dystrophy

    Science.gov (United States)

    ... alopecia, and nail dystrophy is a type of severe combined immunodeficiency (SCID), which is a group of disorders characterized ... Diseases Educational Resources (7 links) Boston Children's Hospital: Severe Combined Immunodeficiency Disease InfoSearch: T-cell immunodeficiency, congenital alopecia and ...

  13. A Case of Alopecia Areata Treated with Bee Venom and Carthami Flos Herbal Acupuncture

    Directory of Open Access Journals (Sweden)

    Kim Kyung-Woon

    2004-06-01

    Full Text Available Objective : Alopecia areata is a common disease and the difficulty of its medical management is well known. This study was designed to investigate the effect of bee venom and Carthami Flos herbal acupuncture. Methods : The patient was managed by bee venom, carthami-flos herbal acupuncture and General acupunture. Herbal acupuncture was injected subcutaneously into the lesion. We checked involvement in plaque, according to evaluation of the effect on alopecia areata. Result : After 5 month of treatment, the lesion had been replaced with new terminal hair. Evaluation of the effect on alopecia areata The score changed from 0 to 3 point. Conclusion : These result suggest that bee venom and Carthami Flos herbal acupuncture has good effect on alopecia areata. But further studies are required to concretely prove the effectiveness of bee venom and Carthami Flos herbal acupuncture for treating alopecia areata.

  14. Epidemiology and burden of alopecia areata: a systematic review

    Directory of Open Access Journals (Sweden)

    Villasante Fricke AC

    2015-07-01

    Full Text Available Alexandra C Villasante Fricke, Mariya MitevaDepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USABackground: Alopecia areata (AA is an autoimmune disorder characterized by patches of non-scarring alopecia affecting scalp and body hair that can be psychologically devastating. AA is clinically heterogenous, and its natural history is unpredictable. There is no preventative therapy or cure.Objective: The objective of this study is to provide an evidence-based systematic review on the epidemiology and the burden of AA.Methods and selection criteria: A search was conducted of the published, peer-reviewed literature via PubMed, Embase, and Web of Science. Studies published in English within the last 51 years that measured AA’s incidence, prevalence, distribution, disability-adjusted life years (DALYs, quality of life, and associated psychiatric and medical comorbidities were included. Two authors assessed studies and extracted the data.Results: The lifetime incidence of AA is approximately 2% worldwide. Both formal population studies found no sex predominance. First onset is most common in the third and fourth decades of life but may occur at any age. An earlier age of first onset corresponds with an increased lifetime risk of extensive disease. Global DALYs for AA were calculated at 1,332,800 in 2010. AA patients are at risk for depression and anxiety, atopy, vitiligo, thyroid disease, and other autoimmune conditions.Conclusion: AA is the most prevalent autoimmune disorder and the second most prevalent hair loss disorder after androgenetic alopecia, and the lifetime risk in the global population is approximately 2%. AA is associated with psychiatric and medical comorbidities including depression, anxiety, and several autoimmune disorders, and an increased global burden of disease.Keywords: hair loss, hair, prevalence, incidence, burden of disease

  15. Alopecia Areata: news on diagnosis, pathogenesis and treatment.

    Science.gov (United States)

    D'Ovidio, R

    2014-02-01

    This review focuses on recent changes in the clinical, pathogenetic and therapeutic developments with regards to Alopecia Areata. Some new clinical forms and some phenomena have been described for the first time in recent years. Several phenomena previously observed such as the Renbok, the Koebner and the possibility that an exclamation mark hair can resume its physiological growth have been confirmed. The pathogenetic role of cytotoxic cells is increasingly evident, as well as the deficit of cells and the factors regulating the autoimmune response. The concept of immune privilege of the hair follicle has had further confirmation and have been identified some of the molecular mechanisms such as the expression of the receptors for killer lymphocytes on the trichokeratinocytes of the Outer Root Sheat. There is a renewed interest on the possible role of mast cell as a key element in the acute and chronic phases of the disease. New therapies are focused on the inhibition of the killer cells directed against antigens not yet fully specified of the hair follicle and on the restoration of the immune privilege of this structure. Alopecia Areata is a disease with high emotional impact, able to reduce the quality of life of patients and their family entourage. It is often frustrating for those affected and for the therapists due to its evolution quite unpredictable and the mixed response to the few validated therapies. Investment in research originate almost exclusively from voluntary associations of patients, which need to be known and supported.

  16. Evaluation of the relationship between androgenetic alopecia and demodex infestation

    Directory of Open Access Journals (Sweden)

    Zari Javidi

    2008-01-01

    Full Text Available Introduction: Androgenetic alopecia (AGA is one of the most common dermatologic disorders with a multifactorial etiology. Inflammatory activators such as Demodex infestation may play a role in the pathogenesis of some cases of androgenetic alopecia that do not respond to common treatments such as minoxidil and finasteride. The goal of this study is to evaluate the relationship between Demodex infestation and AGA. Materials and Methods: In this case-control study, 41 patients with AGA referred to the Dermatology Clinic of Imam Reza Hospital and 33 healthy individuals were evaluated as control. All of them were between 20 and 40 years old men. In order to identify Demodex infestation they were referred to the Parasitology laboratory. Results: Demodex was detected in 19.5% of patients and 15.2% of controls; therefore, there was no significant relationship between them statistically ( P = 0.0787. Most of patients (85.4% had greasy hair. The most common pattern of baldness was II degree in Hamilton scale. Conclusion: There is no relation between AGA and Demodex.

  17. Serum Vitamin D in patients with alopecia areata

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    Ola Ahmed Bakry

    2016-01-01

    Full Text Available Background: Alopecia areata (AA is a common, recurrent, autoimmune hair disorder. It has been found that vitamin D deficiency is associated with many autoimmune diseases. Aims: The current study aimed to estimate serum levels of 25-hydroxy vitamin D in patients with AA. Materials and Methods: This case–control study included 60 patients with AA and 60 age, gender, skin phototype, and body mass index-matched healthy subjects as a control group. Levels of serum 25-hydroxy vitamin D were estimated using ELISA technique. Results: Serum 25-hydroxy vitamin D levels were significantly lower in AA cases when compared with healthy controls (P < 0.001. The least values were significantly associated with alopecia totalis/universalis compared with patchy AA (P< 0.001 and ophiasis (P = 0.04. Severe AA showed significantly the lowest vitamin D levels compared with cases with mild (P = 0.002 and moderate disease (P = 0.03. A significant inverse correlation was found between 25-hydroxy vitamin D levels and age of the patients (r = −0.38; P = 0.03. There was no significant association between serum 25-hydroxy vitamin D levels and gender, disease duration, disease recurrence, nail affection, duration of sun exposure/day, or positive family history of AA. Conclusion: AA patients have lower levels of 25-hydroxy vitamin D than healthy subjects. More studies are required to assess the value of vitamin D supplementation in the treatment of that disease.

  18. A study of immunoglobulins and complements (C3 &C4 in alopecia areata

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    Sharma R

    1995-01-01

    Full Text Available Estimation of serum Immunoglobulins (IgG, IgM and IgA and complements (C3 and C4 was carried out in 100 cases of alopecia areata as per method described by Mancini (1965.[1] Clinically patients were divided in two groups, alopecia areata circumscribed (group I and severe alopecia areata (group II. Significant decrease in levels of one or more Immunoglobulins were observed in most of the patients. However, Serum complements (C3 and C4 were within range of normal control values

  19. Frontal Fibrosing Alopecia Coexisting with Lupus Erythematosus: Poor Response to Hydroxychloroquine.

    Science.gov (United States)

    Contin, Letícia Arsie; Martins da Costa Marques, Elisa Raquel; Noriega, Leandro

    2017-01-01

    Lupus erythematosus, especially the discoid form, and lichen planopilaris may be associated and can occur in different topographies (coexistence) or in the same lesion (lupus eythematosus/lichen planus overlap syndrome). Frontal fibrosing alopecia is considered a variant form of lichen planopilaris and is characterized by frontotemporal hairline and eyebrow involvement. Of the association with lupus erythematosus we have only a few descriptions. Hydroxychloroquine and chloroquine diphosphate are antimalarial drugs described as viable treatment options for both diseases, due to an antilymphocytic effect. The association between frontal fibrosing alopecia and lupus erythematosus (discoid or systemic) is reported in this article, showing a progressive alopecia in the frontotemporal hairline despite treatment with hydroxychloroquine.

  20. Childhood alopecia areata: A study of 89 patients

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    Sibel Doğan

    2014-09-01

    Full Text Available Background and Design: Alopecia areata (AA is a frequent type of acquired hair loss with a sudden onset. The aim of this study was to investigate the epidemiological and clinical features of AA and diseases associated with AA in the Turkish pediatric population. Materials and Methods: We retrospectively evaluated the medical data of patients under 16 years of age who were admitted to the pediatric dermatology outpatient clinic at Hacettepe University Hospital between 2006 and 2011 with a diagnosis of AA, alopecia totalis (AT and alopecia universalis (AU. Results: A total of 89 patients (34 females and 55 males, were included in this study. The mean age of the subjects was 9.8±3.4 years (range: 18 months-16 years. 9% (n=8 patients had other autoimmune diseases: Hashimoto's thyroiditis in 5, vitiligo in 1, juvenile rheumatoid arthiritis (JRA in 1 and morphea in 1 patient. AA was located on the scalp in 86.5% (n=77 of the patients, 7.9% (n=7 of the patients had AA on the scalp together with eyelashes, eyebrows and the body. AT was noted in 1, AU was noted in 4 patients. Severity of hair loss was <25% in 94.3% (n=84 of the patients according to the involved area. Hashimoto's thyroiditis was diagnosed in 5 patients; these patients had normal thyroid function tests (TFT. TFT abnormalities were detected in 27% (n=24 of the patients. 24.7% (n=22 of these patients were diagnosed with clinically insignificant thyroid disorder, 2 patients had compansated hypothyroidism (n=2. Eight patients (9% patients were found to be positive for anti-thyroid peroxidase antibody (Anti-TPO ab. Antithyroglobulin antibody (Anti-TG Ab elevation was noted in 3.3% (n=3 and antinuclear antibody (ANA positivity was noted in 9% (n=8. Nail changes were detected in 12.3% (n=11 of the patients as leukonychia (n=2, longitudinal striation (n=2, trachyonychia (n=1, onychoschizia (n=1 and pitting (n=1. Conclusion: Childhood AA usually causes limited hair loss. TFT anomalies can

  1. Estudo do manejo do estresse em pacientes acometidos por alopecia areata Estudio del manejo del estrés en pacientes acometidos por alopecia areata A study of stress management in patients stricken by alopecia areata

    Directory of Open Access Journals (Sweden)

    Simone Maria Godinho

    2009-03-01

    Full Text Available Alopecia Areata é uma dermatose caracterizada pela perda repentina de pêlos em uma única ou em várias áreas, na forma de círculo. Normalmente a perda se inicia no couro cabeludo, podendo também ocorrer em outras partes do corpo. Fatores emocionais traumáticos são referidos como desencadeantes. Um grupo de 12 pacientes acometidos de alopecia areata foi avaliado por meio de entrevista psicológica e do método de Rorschach (Sistema Compreensivo por Exner, com vista a identificar as condições de personalidade dos pacientes no que se refere ao manejo do estresse. Todos os pacientes relataram episódios traumáticos em suas vidas que poderiam ser considerados como desencadeantes da doença, e nove apresentaram nítidas dificuldades no controle e manejo do estresse.Alopecia Areata es una dermatosis caracterizada por la pierda de pelos, de forma rápida y en áreas. La pierda ocurre normalmente en los cabellos, como también en partes del cuerpo. Factores emocionales traumáticos son referidos como desencadenantes. Un grupo de 12 pacientes acometidos de alopecia areata fue evaluado por medio de entrevista psicológica y método de Rorschach (Sistema Comprensivo por Exner, pretendiendo un estudio exploratorio de la dinámica emocional y de la influencia de los factores psicológicos en la etiología de la alopecia areata. Todos los pacientes relataron episodios traumáticos en sus vidas que podrían ser considerados como desencadenantes de la enfermedad, y nueve presentaron nítidas dificultades en el control y manejo del estrés.Alopecia areata is a common dermatological disorder characterized by the rapid loss of hair in single or multiple patches. Hair loss is often on the scalp, but can also occur in other areas of the body. Psychological traumas have often been cited as precipitating factors. An evaluation of a group of twelve patients diagnosed with alopecia areata was undertaken using psychological interviews and the Rorschach Test

  2. Primary cicatricial alopecias: a review of histopathologic findings in 38 patients from a clinical University Hospital in Sao Paulo, Brazil

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    Emanuella Rosyane Duarte Moure

    2008-01-01

    Full Text Available BACKGROUND: Scarring alopecias are classified into primary and secondary types according to the initial site of inflammation. In primary scarring alopecias, the hair follicle is the main target of destruction; the term secondary cicatricial alopecia implies that follicular destruction is not the primary pathologic event. AIMS: To review the histopathologic diagnoses of cases of cicatricial alopecia in order to classify them according to the North American Hair Research Society. PATIENTS AND METHODS: Patients with biopsy specimens diagnosed as cicatricial alopecia seen from 2000 to 2005 at the Dermatologic Department of Hospital das Clinicas, São Paulo University Medical School had hematoxylin and eosin, Periodic acid-Schiff and Weigert stained slides reevaluated and sub-typed into different primary cicatricial alopecias. RESULTS: Thirty-eight cases of primary cicatricial alopecias were reclassified as: chronic cutaneous lupus (17, lichen planus pilaris (4, pseudopelade of Brocq (12, folliculitis decalvans (3, dissecting folliculitis (1, and non-specific scarring alopecia (1. In our cases, the methods employed allowed an accurate diagnosis in 12 of 13 cases (92.3% previously classified as non-specific cicatricial alopecias. CONCLUSIONS: Even in the late, pauci or non-inflammatory phases, an approach with systematic evaluation of a constellation of criteria in routine hematoxylin and eosin stain, Periodic acid-Schiff and Weigert stain allowed for a more accurate diagnosis of cicatricial alopecias.

  3. Pressure alopecia%压力性脱发

    Institute of Scientific and Technical Information of China (English)

    杜旭峰; 曹蕾; 周映; 宋闯; 胡莉芳; 范卫新

    2014-01-01

    压力性脱发(pressure alopecia,PA)的病理生理过程与长期卧床所致的压力性溃疡相类似,常发生在枕部,患者在过去数周内曾有手术或较长时间在重症监护病房的持续静卧、头位固定史,有些患者脱发前曾有头皮压痛、肿胀、甚至溃疡的表现,但部分患者可能仅直接表现为脱发.该文总结已有文献对其作一综述.

  4. DNA polymorphism of HLA class II genes in alopecia areata

    DEFF Research Database (Denmark)

    Morling, N; Frentz, G; Fugger, L;

    1992-01-01

    of the serologically defined HLA-DQw7 specificity. Individuals who carried both DQA1*0501 and DQB1*0301 seemed to have a further increased risk of developing AA compared to individuals carrying only one of these HLA class II genes. Analysis of the combined presence of DQB1*0301 and DPA1*0103 in AA suggests......We investigated the DNA restriction polymorphism (RFLP) of the Major Histocompatibility Complex (MHC) class II genes: HLA-DQA, -DQB, -DPA, and -DPB in 20 Danish patients with alopecia areata (AA) and in healthy Danes. The frequency in AA of the DQB1*0301 and DQw7 associated DQB Bgl/II 4.2 kb...... that an additive risk effect (synergism or interaction) exists between the DQB1*0301 and DPA1*0103 alleles which are situated at different HLA class II loci....

  5. Diesel oil-induced alopecia in two cats.

    Science.gov (United States)

    Declercq, Jan; De Bosschere, Hendrik

    2009-04-01

    Two cats were presented for acute onset of rapidly progressive, bilaterally symmetrical hair loss of the ventrum and limbs. Alopecia occurred within 2 weeks after accidental skin exposure to diesel oil. The remaining hair epilated easily in affected areas. Denuded skin was strikingly dry and had adherent scale. Erythema and demarcation between affected and normal skin by a liquid-line were present in one case. Above this line, the hair could not be removed. The head and the footpads were not involved. Systemic signs were not observed. Both cats made a complete recovery without treatment. Histological examination in one cat revealed severe orthokeratotic hyperkeratosis, mild to moderate acanthosis, follicular keratosis, a moderate dermal infiltrate of mast cells and an almost complete absence of sebaceous glands. If skin contact with diesel oil occurs in a cat, thorough washing of skin and haircoat after soaking in prue vegetable oil is recommended.

  6. What can we learn from animal models of Alopecia areata?

    Science.gov (United States)

    McElwee, Kevin J; Yu, Mei; Park, Sung-Wook; Ross, Elizabeth K; Finner, Andreas; Shapiro, Jerry

    2005-01-01

    Alopecia areata (AA) is a hair loss disease marked by a focal inflammatory infiltrate of dystrophic anagen stage hair follicles by CD4+ and CD8+ lymphocytes. Although AA is thought to be an autoimmune disorder, definitive proof is lacking. Moreover, characterization of the primary pathogenic mechanisms by which hair loss is induced in AA is limited. In this context, animal models may provide a vital contribution to understanding AA. Recent research using animal models of AA has focused on providing evidence in support of a lymphocyte-mediated pathogenic mechanism consistent with AA as an autoimmune disease. In the future, research with both humans and animal models shall likely concentrate on identifying the primary antigenic epitopes involved in AA and the genetics of AA susceptibility. With a comprehensive understanding of the key elements in AA pathogenesis, new avenues for therapeutic research and intervention will be defined.

  7. Eosinophilic Esophagitis: Another Atopy-Related Alopecia Areata Trigger?

    Science.gov (United States)

    Ibrahim, Omer; Bergfeld, Wilma F; Piliang, Melissa

    2015-11-01

    Alopecia areata (AA) is associated with atopy in 10-22% of patients, twice the prevalence in the general population. Patients can present with concomitant atopic dermatitis, hay fever, asthma, and even allergies to dust mites. In many cases, severity and flares of these atopic diatheses correlate with severity of AA. Herein we present a patient with AA affected by contemporaneous eosinophilic esophagitis (EoE). EoE is a recently recognized allergic disorder, mediated by eosiniphils and histamine. It is characterized by esophageal dysfunction and intraepithelial microabscesses. We propose that EoE be considered as a condition falling within the realm of atopic diseases, and a potential trigger of AA in affected patients.

  8. Severe dermographism after topical therapy with diphenylcyclopropenone for alopecia universalis.

    Science.gov (United States)

    Skrebova, N; Nameda, Y; Takiwaki, H; Arase, S

    2000-04-01

    We describe here a 19-year-old Japanese man with an 11-year history of alopecia universalis, who, after the 1st application of a 0.003% diphenylcyclopropenone (DPCP) solution to the whole scalp, developed acute contact dermatitis at the test site, together with widespread severe dermographism. Every 3 weeks, persistence of the severe urticarial reaction and efficacy of treatment were monitored by constant pressure stimuli in a series of pressure tests, and subsequently evaluated by laser Doppler flowmetry (LDF). Although, on pressure tests, the urticarial response was found to significantly improve after starting treatment, erythematous responses continued to appear for nearly 3 months. The persistent course of these side-effects in our patient strongly suggests that precautions must currently be taken in the therapeutic use of potent sensitizers such as DPCP.

  9. The Frequency Distribution of Celiac Autoantibodies in Alopecia Areata

    Science.gov (United States)

    Mokhtari, Fatemeh; Panjehpour, Tayebeh; Naeini, Farahnaz Fatemi; Hosseini, Sayed Mohsen; Nilforoushzadeh, Mohammad Ali; Matin, Marzieh

    2016-01-01

    Background: Alopecia areata (AA) is a noncicatricial (nonscarring) alopecia. The association between AA and celiac disease (CD) is debatable. Several studies declare the relationship between AA and CD as measurement of celiac autoantibodies (anti-gliadin IgA and anti-gliadin IgG), but a few studies consider anti-tissue transglutaminase IgA. The aim of this study was to evaluate the frequency distribution of celiac autoantibodies (all of them) in patients with AA compared with controls. Methods: This study is a case–control study. Thirty-five patients entered in each group. Anti-gliadin IgA, anti-gliadin IgG, and anti-tissue transglutaminase IgA were tested in all patients. Samples were examined in ELISA method with binding site's kits, and the result was reported as positive/negative. Finally, the frequency distribution of autoantibodies was examined. Results: The age average did not show a significant difference between two groups (P = 0.62). In addition, there was no significant difference between the two groups based on gender (P = 0.15). The prevalence of antibody in case and control groups was 2.85% and 0%, respectively. There was no significant difference between the two groups (P = 0.31). Conclusions: There may be a relationship between CD and AA, but the absence of statistical association between AA and CD does not mean that there is no relationship between gluten and AA in certain patients. Thus, we have shown here that the biological tests to search for CD do not bring information and proof enough, and it is why we recommend another approach to disclose gluten intolerance in AA patients. PMID:27833723

  10. THE ROLE OF ESTROGEN IN WOMEN WITH ANDROGENETIC ALOPECIA

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    Putu Diah Pratiwi

    2013-07-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE Hair loss may accured in both male and female population. Hair loss usually accured in Telogenic phase, meanwhile in Anagenic phase hair loss due to chemotherapy or radiation. Female pattern hair loss (FPHL is regarded as hair fall type which is accured in women in common and known as female androgenetic alopecia. Almost 40%, 50 years old female shown hair fall sign, which is developed progressive fibrosing alopecia of central scalp, especially in frontal and parietal area. There are two common treatment for Female pattern Hair Loss are Minoxidil for topical use, and Fenesteride by oral. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs, in turn increase anagenic phase and represed telogenic phase. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

  11. Identification of Autoantigen Epitopes in Alopecia Areata.

    Science.gov (United States)

    Wang, Eddy H C; Yu, Mei; Breitkopf, Trisia; Akhoundsadegh, Noushin; Wang, Xiaojie; Shi, Feng-Tao; Leung, Gigi; Dutz, Jan P; Shapiro, Jerry; McElwee, Kevin J

    2016-08-01

    Alopecia areata (AA) is believed to be a cell-mediated autoimmune hair loss disease. Both CD4 and cytotoxic CD8 T cells (CTLs) are important for the onset and progression of AA. Hair follicle (HF) keratinocyte and/or melanocyte antigen epitopes are suspected potential targets of autoreactive CTLs, but the specific epitopes have not yet been identified. We investigated the potential for a panel of known epitopes, expressed by HF keratinocytes and melanocytes, to induce activation of CTL populations in peripheral blood mononuclear cells. Specific synthetic epitopes derived from HF antigens trichohyalin and tyrosinase-related protein-2 induced significantly higher frequencies of response in AA CTLs compared with healthy controls (IFN-gamma secretion). Apoptosis assays revealed conditioned media from AA peripheral blood mononuclear cells stimulated with trichohyalin peptides elevated the expression of apoptosis markers in primary HF keratinocytes. A cytokine array revealed higher expression of IL-13 and chemokine ligand 5 (CCL5, RANTES) from AA peripheral blood mononuclear cells stimulated with trichohyalin peptides compared with controls. The data indicate that AA affected subjects present with an increased frequency of CTLs responsive to epitopes originating from keratinocytes and melanocytes; the activated CTLs secreted soluble factors that induced apoptosis in HF keratinocytes. Potentially, CTL response to self-antigen epitopes, particularly trichohyalin epitopes, could be a prognostic marker for human AA.

  12. A comparative study of treatment modalities in female androgenetic alopecia

    Directory of Open Access Journals (Sweden)

    Mansuri Uzzaif U.

    2016-04-01

    Results: 70% (n=42 of patients were in the age group 18-30 years. 56.67% (n=34 had alopecia of Ludwig pattern type 2. Hypothyroidism was the major associated medical illness seen in 20% (n=20 of patients. Family history was seen in 46.66% (n=28. 73.33% (n=44 had stress in the range of 5-7 on a visual analogue scale (VAS of 10. Excellent improvement was observed in 33.33% of patients of Group A (Minoxidil only, and in 60% (n=36 of patients of Group B (Minoxidil + PRP. Pruritis was the most common side effect seen in 13.33% (n=8 patients. Conclusions: Non-invasive management for AGA is a safe, effective and promising tool for hair growth. It offers better patient compliance, less side effects and only topical anesthesia is required. Multimodality approach in the treatment of hair loss gives excellent response, which is seen in our study as combination therapy (2% minoxidil with PRP is more effective than topical minoxidil alone. [Int J Res Med Sci 2016; 4(4.000: 1229-1236

  13. Evaluation of clinical significance of dermoscopy in alopecia areata

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    Akhila Sai Guttikonda

    2016-01-01

    Full Text Available Background: Alopecia areata (AA is a common, chronic inflammatory disease characterized by nonscarring hair loss on the scalp or any hair-bearing area of the body. Recently, dermoscopy, a noninvasive diagnostic procedure, has been employed for the diagnosis of AA. Aim: To evaluate various dermoscopic patterns in AA and correlate these patterns with the disease activity and severity. Materials and Methods: Dermoscopy was performed on AA patients using DL1 dermoscope (magnification ×10 was used. The dermoscopic patterns recorded were analyzed to identify any correlation with the disease activity and severity. Results: A total of fifty patients of AA were recruited in the study. Female outnumbered males with the ratio being 1.173:1. Mean age of the patients was 25.06 years. Mean duration of disease was 14 months. The most common site involved was scalp (80% and type noted was patchy (84%. Various dermoscopic patterns noted were yellow dots (YD (88%, short vellus hair (66%, black dots (BD (58%, broken hairs (BHs (56%, tapering hair (TH (26%, Coudability hairs (14%, pigtail hair (14%, and Pohl-Pinkus constrictions (2%. Statistically significant correlation was observed between BD, BHs, THs, and disease activity. No significant correlation was found between severity and any of the dermoscopic features. Conclusion: The most common dermoscopic pattern in our study was YD. Presence of BDs, BHs, and THs indicate active disease. Dermoscopic patterns were not affected by severity of the disease.

  14. Doxorubicin-induced alopecia is associated with sebaceous gland degeneration.

    Science.gov (United States)

    Selleri, Silvia; Seltmann, Holger; Gariboldi, Silvia; Shirai, Yuri F; Balsari, Andrea; Zouboulis, Christos C; Rumio, Cristiano

    2006-04-01

    Alopecia, accompanied by skin dryness, is one of the distressing side effects often occurring in chemotherapy-treated cancer patients. Little is known of the effects of chemotherapy on sebaceous glands, despite their importance in hair follicle homeostasis. This study investigates sebaceous gland morphology and the response of SZ95 sebaceous gland cell line to doxorubicin (DXR) treatment. The morphology of sebaceous glands during intraperitoneal DXR treatment was investigated by optical and electron microscopy in a 7-day-old rat model and further confirmed in an adult mouse model. Moreover, in vitro studies using the SZ95 sebaceous gland cell line were performed to assess the response of sebocytes to DXR in terms of cell proliferation, apoptosis, and necrosis. DXR treatment induced sebaceous gland regression and occasionally caused their complete disappearance. This observed damage and disappearance preceded DXR-induced hair loss. In vitro experiments using the SZ95 sebaceous gland cell line indicated that DXR treatment induced a differentiation process leading to premature sebocytes apoptosis. Owing to the importance of the sebaceous gland in hair follicle homeostasis, DXR-induced involution of this gland might be related to subsequent hair loss.

  15. Increased Pathological Worry Levels in Patients with Alopecia Areata

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    Basak Sahin

    2017-01-01

    Full Text Available Aim: Alopecia Areata (AA is a type of hair loss that has been considered to have associations with various psychiatric disorders. In this study, we aimed to compare pathological worry levels between patients with AA and healthy controls (HC. Material and Method: Sixty-three patients with AA and 90 HCs were included in the present study after applying inclusion and exclusion criteria. The socio-demographic characteristics, some clinical characteristics, and the scores from the Penn State Worry Questionnaire (PSWQ were compared between groups. Results: The demographic characteristics were found to be similar between groups except for gender. The family history of AA was significantly higher in the AA group. The mean score of PSWQ in the AA group was 44.02 ± 11.59, compared to 39.71 ± 7.77 in the HC group. The mean score of PSWQ was significantly higher in the AA group (t=-3.27, p= 0.001.Discussion: The present study is the first to compare pathological worry between patients with AA and HCs. We suggest that pathological worry should be more thoroughly investigated in patients with AA to improve their quality of life. Also, this can be an effective approach to targeting the patients who may develop anxiety disorder.

  16. Alopecia areata of dental origin in a child.

    Science.gov (United States)

    Samuel, A Victor; Muthu, M S; Gurunathan, Deepa; Sharma, Aruna

    2012-01-01

    Alopecia areata (AA) is a chronic inflammatory disease that involves the hair follicle. Current evidence indicates that hair follicle inflammation in AA is caused by a T-cell-mediated autoimmune mechanism occurring in genetically predisposed individuals. AA has a reported incidence of 0.1%-0.2%, with a lifetime risk of 1.7%. It has also been found that AA accounts for roughly 2% of new dermatology outpatient cases in the US and the UK, 3.8% of cases in China and 6.7% of cases in Kuwait. Pediatric AA constitutes approximately 20% of all AA cases. AA affects males and females equally. The most common site to be affected is the scalp (90%). The face, eyebrows, eyelashes, beard, underarm hair, and pubic hair may be affected and, sometimes, even the entire body. AA requires combined therapy, involving topical or intralesional corticosteroids, immune therapy with diphenylcyclopropenone, and even psychotherapy. In some cases, treatment consists of simply eliminating the dental infectious process. This case report describes AA of dental origin in a 9-year-old girl, which resolved after management of the dental problem.

  17. Alopecia areata of dental origin in a child

    Directory of Open Access Journals (Sweden)

    A Victor Samuel

    2012-01-01

    Full Text Available Alopecia areata (AA is a chronic inflammatory disease that involves the hair follicle. Current evidence indicates that hair follicle inflammation in AA is caused by a T-cell-mediated autoimmune mechanism occurring in genetically predisposed individuals. AA has a reported incidence of 0.1%-0.2%, with a lifetime risk of 1.7%. It has also been found that AA accounts for roughly 2% of new dermatology outpatient cases in the US and the UK, 3.8% of cases in China and 6.7% of cases in Kuwait. Pediatric AA constitutes approximately 20% of all AA cases. AA affects males and females equally. The most common site to be affected is the scalp (90%. The face, eyebrows, eyelashes, beard, underarm hair, and pubic hair may be affected and, sometimes, even the entire body. AA requires combined therapy, involving topical or intralesional corticosteroids, immune therapy with diphenylcyclopropenone, and even psychotherapy. In some cases, treatment consists of simply eliminating the dental infectious process. This case report describes AA of dental origin in a 9-year-old girl, which resolved after management of the dental problem.

  18. Jet cryotherapy vs clobetasol proprionate lotion in alopecia areata.

    Science.gov (United States)

    Faghihi, Gita; Radan, Mohammadreza

    2014-01-01

    Alopecia areata (AA) is a common disease of hair follicles. Cryotherapy has been employed to stimulate hair regrowth. The current investigation evaluated the efficacy of this method in patchyAA. Forty patients older than 5 years and with 120 recalcitrant patches were enrolled in the study. AA covered less than 50% of the patients' scalps. In each individual, one lesion was treated with N2 jet cryotherapy once a week for a period of 12 weeks, while another lesion was treated with topical 0.05% clobetasol proprionate lotion. All patients were followed from weeks 2 to 16. Thirty-eight of 40 patients completed therapy. The overall response rate of patches was 80% in the cryotherapy group and 91.5% in the clobetasol group. Complete recovery (>95% terminal hair growth) was not obtained in any patient. Results from chi-square test showed no significant difference between improvements in AA in the two groups (reliability 95%). Pearson measurement showed a significant reverse relationship between diameter and duration of patches and the improvement rate in both groups. Liquid nitrogen jet cryotherapy can be a helpful modality in the treatment of AA.

  19. Quality of Life in Alopecia Areata: A Sample of Tunisian Patients

    Directory of Open Access Journals (Sweden)

    Jawaher Masmoudi

    2013-01-01

    Full Text Available Background. Alopecia areata (AA has a significant impact on the quality of life and social interaction of those suffering from it. Our aim was to assess the impact of AA on the quality of life. Methods. Fifty patients diagnosed with AA seen in the Department of Dermatology of Hedi Chaker University Hospital, between March 2010 and July 2010, were included. Quality of life was measured by SF 36; severity of AA was measured by SALT. Results. Eighty percent had patchy alopecia with less than 50% involvement, 12% had patchy alopecia with 50–99% involvement, and 8% had alopecia totalis. Compared with the general population, AA patients presented a significantly altered quality of life, found in the global score and in five subscores of the SF-36: mental health, role emotional, social functioning, vitality, and general health. Gender, age, marital status, and severity of alopecia areata had a significant influence on patients’ quality of life. Conclusions. This study indicates that patients with AA experience a poor quality of life, which impacts their overall health. We suggest screening for psychiatric distress. Studies of interventions such as counseling, psychoeducation, and psychotherapeutic interventions to reduce the impact of the disease may be warranted.

  20. Evaluation of serum homocysteine, high-sensitivity CRP, and RBC folate in patients with alopecia areata

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    Maryam Yousefi

    2014-01-01

    Full Text Available Introduction: Alopecia areata (AA is a common type of hair loss with an autoimmune basis. As the role of homocysteine (Hcys, folate, and CRP has been considered in some autoimmune diseases. Objectives: To evaluate homocysteine, folate and CRP level in AA. Methods: This study was performed on 29 patients who had AA for at least 6 months affecting more than 20% of scalp, and 32 healthy controls. Levels of serum Hcys, blood high-sensitivity CRP, and RBC folate were measured in all subjects. Results: The mean level of RBC folate was significantly lower in the patient group than that in controls (P < 0.001. Also, the level of RBC folate was significantly lower in patients with extensive forms of disease (alopecia totalis/alopecia universalis in comparison with more localized form (patchy hair loss (P < 0.05. Patients with higher "Severity of Alopecia Total" (SALT score had lower RBC folate, as well. Serum Hcys and blood high-sensitivity CRP levels did not show a significant difference in two groups. Conclusion: Patients with alopecia areata have lower level of RBC folate which is in negative correlation with both severity and extension of AA.

  1. Effect of petroleum ether and ethanol fractions of seeds of Abrus precatorius on androgenic alopecia

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    Sukirti Upadhyay

    2012-04-01

    Full Text Available Seeds of Abrus precatorius L., Fabaceae, are commonly used as purgative, emetic, aphrodisiac and in nervous disorder in traditional and folk medicines. In present study petroleum ether and ethanolic extracts of A. precatorius seeds are evaluated for reversal of androgen (testosterone by i.m route induced alopecia in male albino wistar rats and compared to topical administration of standard antiandrogenic drug finasteride for 21 days. The results were reflected from visual observation and histological study of several skin sections via various parameters as anagen to telogen ratio and follicle density/mm area of skin surface. The animal of group 1 who were treated with only testosterone became alopecic on visual observation. Animals of Group 2, 3 and 4 who were treated with finasteride, petroleum ether and ethanolic extract of seed respectively topically along with testosterone (i.m did not developed alopecia. To investigate the mechanism of observed activity, in vitro experiments were performed. Inhibition of 5α-reductase activity by extracts and finasteride suggest that they reversed androgen induced alopecia by inhibiting conversion of testosterone to dihydrotestosterone (potent androgen responsible for androgenic alopecia. So it may be concluded that petroleum ether and ethanolic extract of A. precatorius seed posses anti androgenic alopecia activity due to inhibition of 5α-reductase enzyme.

  2. INTRALESIONAL PLATELET RICH PLASMA vs INTRALESIONAL TRIAMCINOLONE IN THE TREATMENT OF ALOPECIA AREATA: A COMPARATIVE STUDY

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    Shumez H, Prasad PVS, Kaviarasan PK, Deepika R

    2015-01-01

    Full Text Available Background: Alopecia areata (AA is a chronic non-scarring alopecia that involves the scalp and/or body, and is characterized by patchy areas of hair loss without any signs of clinical inflammation. Various therapies have been proposed for their treatment.But none have been shown to alter the course of the disease. Platelet Rich Plasma (PRP is a volume of autologous plasma that has a high platelet concentration. Growth factors released from platelets may act on stem cells in the bulge area of the follicles, stimulating the development of new follicles and promoting neovascularization. Aim: To evaluate and compare the efficacy of intralesional injection of autologous platelet rich plasma with intralesional injection of triamcinolone acetonide (10mg/ml in the treatment of alopecia areata. Methodology: 74 patients with alopecia areata were allocated into 2 groups and treated with triamcinolone and PRP injections. Treatment outcome was measured by taking into account extent and density of regrowth of hair and was expressed as a percentage of overall growth. Results: Forty eight patients were treated with triamcinolone injections and 26 patients were treated with PRP injections. Patients treated with PRP had an earlier response at the end of 6weeks than patients treated with triamcinolone. However, this difference was statistically insignificant. The overall improvement at the end of 9 weeks was 100% for all patients in both groups. Conclusion: PRP is a safe, simple, biocompatible and effective procedure for the treatment of alopecia areata with efficacy comparable with triamcinolone.

  3. Comparing the demographic factors of patient with limited and diffuse type of alopecia areata

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    Mina Daliri

    2010-09-01

    Full Text Available Background: Alopecia areata is a chronic inflammatory disease that involves the hair follicle. Clinically, patients with alopecia areata may have patchy or confluent hair loss on the scalp or body so we conduct a study to compare the demographic aspects of patient with limited and diffuse type of alopecia areata.Materials and Method: We conducted a descriptive-analyzing study in which 306 patient were chosen. The patients were divided into two groups of diffuse and limited Alopecia. Demographic factors including age, gender, disease onset were compared in two groups. Results: Out of 306 patients, 58.8 % were male and 41.2 % were female. 247 patients (80.7% suffered from limited type and 59 patients (19.2% suffered from diffuse type. The mean age of the onset of involvement in limited group was 21.9±12 yr and 15.8±12 yr in diffuse group. The mean duration of involvement in limited group was 18.7 months and 71 months in diffuse group. Conclusion: Diffuse type alopecia areata starts at lower age and has longer duration. Our study results were similar to the others. Like other studies, thyroid disorders and atopic dermatitis are positively correlative to the severity of disease

  4. Alopecia induced by lopinavir plus ritonavir therapy in an HIV patient.

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    Chrysos, George; Mikros, Sotirios; Kokkoris, Stelios; Pastelli, Androula; Kontochristopoulos, George

    2007-07-01

    The most commonly reported side effects related to lopinavir/ritonavir are diarrhea, vomiting, headache, nausea, and increased serum triglycerides and cholesterol levels. About 4% of the patients prescribed lopinavir/ritonavir stop taking it because of side effects. Alopecia, generally involving the scalp, has been reported in patients with HIV infection treated with indinavir but not with lopinavir/ritonavir. We present a 62-year-old man with HIV infection, stage B2, who experienced alopecia totalis of his scalp, eyebrows, and eyelashes beginning 18 months after initiating antiretroviral treatment including lopinavir/ritonavir. No hair loss on the arms, legs, and pubic area was observed. Our patient's drug regimen consisted of lopinavir/ritonavir, efavirenz, and stavudine; in addition, the patient was receiving treatment for diabetes with glivenclamide and metformin for the last 3 years. These drugs have not been shown to cause alopecia. Alopecia reversed completely 2 months after substituting nelfinavir for lopinavir/ritonavir without any other change of treatment and his eyelashes and eyebrows grew back as well. To our knowledge, this is the second case of lopinavir/ritonavir-associated alopecia totalis reported in the international literature.

  5. Resolution of paraneoplastic alopecia following surgical removal of a pancreatic carcinoma in a cat.

    Science.gov (United States)

    Tasker, S; Griffon, D J; Nuttall, T J; Hill, P B

    1999-01-01

    A 13-year-old female neutered domestic longhaired cat was presented with a five-month history of progressive weight loss and bilaterally symmetrical alopecia of the ventrum, limbs and perineum. The alopecic skin had a shiny appearance and hair in the non-alopecic areas was easily epilated. Fine needle aspirate cytology of a palpable cranial abdominal mass revealed it to be of epithelial or glandular origin. A pancreatic mass was excised by left pancreatectomy during exploratory laparotomy, and histopathology and skin biopsies confirmed a diagnosis of pancreatic carcinoma with concurrent paraneoplastic alopecia. No evidence of metastases was found on liver and lymph node biopsies. At re-examination 10 weeks after surgery, the hair had fully regrown. Skin signs recurred after 18 weeks and metastatic spread of the tumour was confirmed on postmortem examination. This case confirms that paraneoplastic alopecia associated with internal malignancies is a potentially reversible process if the internal neoplasm is excised.

  6. A case of feline paraneoplastic alopecia with secondary Malassezia-associated dermatitis.

    Science.gov (United States)

    Godfrey, D R

    1998-08-01

    A 13-year-old neutered female domestic shorthaired cat had progressive ventral abdominal alopecia attributed initially to hyperthyroidism. Corrective treatment by unilateral thyroidectomy did not, however, resolve the dermatosis and the alopecia progressed to involve the whole ventral trunk, the lower limbs and the head. Pruritus of the lower limbs was a prominent feature and was associated with the finding of Malassezia on cytology; Malassezia-associated dermatitis was diagnosed. Resolution of pruritus was seen after treatment with oral ketoconazole and a cleansing shampoo to eliminate the yeast, but severe polyphagia, small intestinal diarrhoea and polydipsia developed subsequently and the cat was euthanased. Necropsy revealed an exocrine pancreatic adenocarcinoma with hepatic metastases. The pancreatic, hepatic and dermatological lesions were found to be typical of feline paraneoplastic alopecia (FPA). Malassezia-associated dermatitis can be associated with pruritus in cats with FPA.

  7. The effects of clomipramine hydrochloride in cats with psychogenic alopecia: a prospective study.

    Science.gov (United States)

    Mertens, Petra A; Torres, Sheila; Jessen, Carl

    2006-01-01

    A double-blind, placebo-controlled clinical trial was conducted to determine the efficacy of clomipramine hydrochloride in cats with psychogenic alopecia. Twenty-five cats were randomly assigned to receive clomipramine hydrochloride (0.5 mg/kg orally q 24 hours) or placebo for 56 days. Eleven cats in each group completed the trial. The results of this study showed that clomipramine hydrochloride failed to demonstrate significant changes in the number of grooming bouts, hair regrowth, and the area of alopecia in cats with psychogenic alopecia when compared to a placebo. It was uncertain whether these results reflected a lack of drug efficacy, insufficient treatment duration, or an insufficient number of cases enrolled.

  8. The case of ichthyosis follicularis, alopecia and photophobia syndrome with retinal detachment

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    Bengü Nisa Akay

    2014-06-01

    Full Text Available Ichtiyosis follicularis, alopecia and photophobia (IFAP syndrome is a rare congenital ectodermal syndrome with X-linked inheritance. It occurs as a result of missense mutation in chromosome Xp22.11-Xp22.13 locus of MBTPS2 gene. It usually affects men and family history is always negative. Ichtiyosis follicularis and alopecia starts with birth. Photophobia and eye symptoms begin in early infancy or childhood. Other manifestations of the syndrome include short stature, mental retardation and seizures. There are no spesific histopathological findings specific for ichtyosis follicularis. A 29 years old male patient was admitted to outpatient clinic. Dermatological examination revealed keratosis pilaris localized to scalp, extremities and anterolateral of the body. Patient had xerosis, diffuse alopecia and prominent folicular appereance. Eye examination revealed cataracts and vision loss. These findings led us to IFAP syndrome diagnosis. The patient is presented for the rarity of the syndrome in the literature.

  9. Trichotillomania: a case report with clinical and dermatoscopic differential diagnosis with alopecia areata*

    Science.gov (United States)

    Pinto, Ana Cecília Versiani Duarte; de Andrade, Tatiana Cristina Pedro Cordeiro; de Brito, Fernanda Freitas; da Silva, Gardênia Viana; Cavalcante, Maria Lopes Lamenha Lins; Martelli, Antonio Carlos Ceribelli

    2017-01-01

    Trichotillomania is a psychodermatologic disorder characterized by uncontrollable urge to pull one's own hair. Differential diagnoses include the most common forms of alopecia such as alopecia areata. It is usually associated with depression and obsessive-compulsive disorder. Trichotillomania treatment standardization is a gap in the medical literature. Recent studies demonstrated the efficacy of N-acetylcysteine (a glutamate modulator) for the treatment of the disease. We report the clinical case of a 12-year-old female patient who received the initial diagnosis of alopecia areata, but presented with clinical and dermoscopic features of trichotillomania. She was treated with the combination of psychotropic drugs and N-acetylcysteine with good clinical response. Due to the chronic and recurring nature of trichotillomania, more studies need to be conducted for the establishment of a formal treatment algorithm. PMID:28225970

  10. A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.

    Science.gov (United States)

    Lee, Seong Min; Goellner, Joseph J; O'Brien, Charles A; Pike, J Wesley

    2014-11-01

    The syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is a genetic disease of altered mineral homeostasis due to mutations in the vitamin D receptor (VDR) gene. It is frequently, but not always, accompanied by the presence of alopecia. Mouse models that recapitulate this syndrome have been prepared through genetic deletion of the Vdr gene and are characterized by the presence of rickets and alopecia. Subsequent studies have revealed that VDR expression in hair follicle keratinocytes protects against alopecia and that this activity is independent of the protein's ability to bind 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. In the present study, we introduced into VDR-null mice a human VDR (hVDR) bacterial artificial chromosome minigene containing a mutation that converts leucine to serine at amino acid 233 in the hVDR protein, which prevents 1,25(OH)2D3 binding. We then assessed whether this transgene recreated features of the HVDRR syndrome without alopecia. RT-PCR and Western blot analysis in one strain showed an appropriate level of mutant hVDR expression in all tissues examined including skin. The hVDR-L233S mutant failed to rescue the aberrant systemic and skeletal phenotype characteristic of the VDR null mouse due to the inability of the mutant receptor to activate transcription after treatment with 1,25(OH)2D3. Importantly, however, neither alopecia nor the dermal cysts characteristic of VDR-null mice were observed in the skin of these hVDR-L233S mutant mice. This study confirms that we have created a humanized mouse model of HVDRR without alopecia that will be useful in defining additional features of this syndrome and in identifying potential novel functions of the unoccupied VDR.

  11. Androgenetic alopecia and risk of coronary artery disease

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    Lata Sharma

    2013-01-01

    Full Text Available Background: Androgenetic alopecia (AGA or male pattern baldness (MPB has been found to be associated with the risk of coronary artery disease (CAD. The well-known risk factors are family history of CAD, hypertension, increased body mass index (BMI, central obesity, hyperglycemia, and dyslipidemia. The newer risk factors are serum lipoprotein-a (SL-a, serum homocysteine (SH, and serum adiponectin (SA. Aim : Identifying individuals at risk of CAD at an early age might help in preventing CAD and save life. Hence, a comparative study of CAD risk factors was planned in 100 males of AGA between the age of 25 and 40 years with equal number of age- and sex-matched controls. Materials and Methods : Patients of AGA grade II or more of Hamilton and Norwood (HN Scale and controls were examined clinically and advised blood test. The reports were available for fasting blood sugar (FBS, serum total serum cholesterol (SC in 64 cases, 64 controls; lipoproteins (high, low, very low density, HDL, LDL, VLDL, serum triglycerides (ST in 63 cases, 63 controls; SL-a in 63 cases, 74 controls; SH in 56 cases, 74 controls; and SA in 62 cases, 74 controls. Results : In these cases family history (FH of AGA and CAD was significantly high. The blood pressure (BP was also found to be significantly high in the cases. The difference of mean serum HDL, LDL, VLDL, ST, SH, and SL-a in cases and controls were statistically significant and with increasing grade of AGA, the risk factors also increased. Conclusion : Patients with AGA appear to be at an increased risk of developing CAD, therefore, clinical evaluation of cases with AGA of grade II and above may be of help in preventing CAD in future.

  12. Thyroid disorders associated with alopecia areata in Egyptian patients

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    Ola A Bakry

    2014-01-01

    Full Text Available Context: Alopecia areata (AA is a common form of localized, non-scarring hair loss. The etiopathogenesis of the disease is still unclear, but the role of autoimmunity is strongly suggested. AA is commonly associated with various autoimmune disorders; the most frequent among them is autoimmune thyroid disorders. Aim: To determine whether AA is associated with thyroid autoimmunity or thyroid function abnormalities in Egyptian patients. Materials and Methods: Fifty subjects with AA (37 males and 13 females without clinical evidence of thyroid disorders were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital, Menoufiya Governorate, Egypt, during the period from June 2009 to February 2010. They were divided into 3 groups according to severity of AA. Fifty age and sex-matched healthy volunteers (35 males and 15 females were selected as a control group. Every case and control were subjected to history taking, complete general and dermatological examination. Venous blood samples were taken from cases and controls after taking their consents for measurement of thyroid stimulating hormone (TSH, free T3, freeT4 and detection of Anti-thyroglobulin Antibody (Tg-Ab and Anti-thyroid Peroxidase Antibody (TPO-Ab. Results: Subclinical hypothyroidism was detected in 16% of cases. There were statistically significant differences between cases and controls regarding levels of TSH, free T3 and free T4. There were significant differences between cases and controls regarding the presence of Tg-Ab and TPO-Ab. Conclusions: Every patient with AA should be screened for thyroid functions and presence of thyroid autoantibodies even in absence of clinical manifestations suggestive of thyroid affection.

  13. What do Patients with Alopecia Areata Think About Their Diseases?

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    Müzeyyen Gönül

    2013-12-01

    Full Text Available Objective: Alopecia areata (AA is a non-scarring disorder characterized by sudden loss of hairs. There is only one study that investigated the concepts of AA patients about their diseases. In this study self concepts about the causes and course of their disorder and their learning sources were asked to AA patients. Methods: 51 AA patients were enrolled to the study. The causes and the exacerbating factors of their disorders, how they have been directed to dermatology section, their concepts about the course of the disease and information sources were asked to the patients. Results: 30 of AA patients were male 21 were female. The ages of the patients varied between 15 and 63 years. While 49% of the patients accused stress as the cause, 18% was worried that it was a possible sign of cancer. 63% patients thought that stress played a role in exacerbating their disease. 60% of the patients thought that AA might improve completely but 16% did not have hope of improvement. While 39% patients received information from dermatologist, 28% did not investigate their disorder. The patients' answers to the questionaire were not different according to sex, education status, family history of the patients, recurrence of the disorder and if there was associated diseases but it was found significant that as the ages of the patients increased they more frequently thought that stress might be the possible exacerbating factor. Conclusion: AA patients blamed stress as the inducing and exacerbating factor of the disorder. However, as about 1/5 patients had worry of cancer and important rate of them had inadequate information about their disorder, dermatologists should give more information to the patients. Also listening and reducing the concern of the patients may positively effect the treatment.

  14. Alopecia and dermatopathy of the lower back following pelvic fractures in three cats.

    Science.gov (United States)

    Declercq, Jan

    2004-02-01

    An alopecia and dermatopathy following pelvic fractures associated with vehicular trauma is reported in three cats. The animals presented 3-4 weeks post injury with acute hair loss, glistening appearance of the skin and erosions involving the lower back. Histological examination revealed atrophy of the hair follicles and adnexal structures and follicular telogenization, dermal fibroplasia and mild lymphocytic infiltrate, fibroplasia and inflammation in the panniculus. Vascular damage secondary to the external trauma to blood vessels supplying the skin over the lumbar region and subsequent ischaemia may represent the pathomechanism of this type of alopecia. Focal permanent hair loss can be expected.

  15. Central centrifugal cicatricial alopecia: what has been achieved, current clues for future research.

    Science.gov (United States)

    Ogunleye, Temitayo A; McMichael, Amy; Olsen, Elise A

    2014-04-01

    Central centrifugal cicatricial alopecia is an inflammatory type of central scalp hair loss seen primarily in women of African descent. The prevalence is unknown, but may vary from 2.7% to 5.7% and increases with age. This review outlines the history and current beliefs and identifies clues for future research for this enigmatic condition. Despite that the cause of central centrifugal cicatricial alopecia is unknown, research is ongoing. The role of cytokeratins, androgens, genetics, and various possible sources of chronic inflammation in disease pathogenesis remain to be elucidated.

  16. Intermediate Uveitis and Alopecia Areata : Is There a Relationship? Report of 3 Pediatric Cases

    NARCIS (Netherlands)

    Ayuso, Viera Kalinina; Pott, Jan Willem; de Boer, Joke Helena

    2011-01-01

    Three previously healthy children, aged 5, 8, and 15 years, with idiopathic intermediate uveitis (IU) and alopecia areata (AA) are described. These are the first 3 cases of which we are aware with this coexistence. The results of extensive diagnostic evaluations were negative in all 3 cases. AA prec

  17. Androgenic alopecia is not useful as an indicator of men at high risk of prostate cancer.

    NARCIS (Netherlands)

    Cremers, R.G.H.M.; Aben, K.K.H.; Vermeulen, S.; Heijer, M. den; Oort, I.M. van; Kiemeney, L.A.L.M.

    2010-01-01

    BACKGROUND: Androgens are assumed to play a central role in the pathophysiology of both prostate cancer (PC) and androgenic alopecia (AA). A correlation between the two phenotypes may be relevant for identification of men at high risk of PC. We evaluated the association between AA at different ages

  18. Quality of life and maladjustment associated with hair loss in women with alopecia androgenetica

    NARCIS (Netherlands)

    J. van der Donk (J.); J.A.M. Hunfeld (Joke); J. Passchier (Jan); K.J. Knegt-Junk (K.); C. Nieboer (C.)

    1994-01-01

    textabstractQuality of life and maladjustment related to hair loss were studied by means of a standardized interview in a group of 58 women with alopecia androgenetica who applied for treatment at the Department of Dermatology. The hair loss was found to have a negative influence on the quality of l

  19. Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus

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    Li Xuan

    2014-01-01

    Full Text Available A 26-year-old Chinese male consulted with the team regarding his alopecia areata and vitiligo for which previous treatment was ineffective. The patient, a homosexual man, denied having a history of drug abuse and of blood transfusion. No member of his family had vitiligo or alopecia. Laboratory studies revealed that the serum for anti-human immunodeficiency virus (HIV antibody was positive. The patient′s CD4 lymphocyte count and CD4/CD8 ratio were both strikingly low (20 cells/mL and 0.04, but no other complaints or opportunistic infections were reported. One month after antiretroviral therapy, the patient′s alopecia areata dramatically improved, but no evident improvement in his vitiligo was found. This case is a very rare case of alopecia areata and vitiligo associated with HIV infection that might be attributed to the generation and maintenance of self-reactive CD8+ T-cells due to chronic immune activation with progressive immune exhaustion in HIV infection.

  20. Acquired generalised neuromyotonia, cutaneous lupus erythematosus and alopecia areata in a patient with myasthenia gravis.

    LENUS (Irish Health Repository)

    O'Sullivan, S S

    2012-02-03

    We describe a patient with the diagnoses of acquired neuromyotonia, cutaneous lupus erythematosus and alopecia areata, occurring many years after a thymectomy for myasthenia gravis associated with a thymoma. We review the current literature on autoimmune conditions associated with myasthenia gravis and thymectomy. To our knowledge, this combination of multiple autoimmune conditions has not been reported previously.

  1. Cure of alopecia areata after eradication of Helicobacter pylori : A new association?

    Institute of Scientific and Technical Information of China (English)

    Germán Campuzano-Maya

    2011-01-01

    Alopecia areata is a disease of the hair follicles, with strong evidence supporting autoimmune etiology. Alopecia areata is frequently associated with immune-mediated diseases with skin manifestations such as psoriasis and lichen planus, or without skin manifestations such as autoimmune thyroiditis and idiopathic thrombocytopenic purpura. Helicobacter pylori (H. pylori ) infection is present in around 50% of the world's population and has been associated with a variety of immune-mediated extra-digestive disorders including autoimmune thyroiditis, idiopathic thrombocytopenic purpura, and psoriasis. A case of a 43-year old man with an 8-mo history of alopecia areata of the scalp and beard is presented. The patient was being treated by a dermatologist and had psychiatric support, without any improvement. He had a history of dyspepsia and the urea breath test confirmed H. pylori infection. The patient went into remission from alopecia areata after H. pylori eradication. If such an association is confirmed by epidemiological studies designed for this purpose, new therapeutic options could be available for these patients, especially in areas where infection with H. pylori is highly prevalent.

  2. UV laser-induced fluorescence spectroscopy and laser Doppler flowmetry in the diagnostics of alopecia

    Science.gov (United States)

    Skomorokha, Diana P.; Pigoreva, Yulia N.; Salmin, Vladimir V.

    2016-04-01

    Development of optical biopsy methods has a great interest for medical diagnostics. In clinical and experimental studies it is very important to analyze blood circulation quickly and accurately, thereby laser Doppler flowmetry (LDF) is widely used. UV laser-induced fluorescence spectroscopy (UV LIFS) is express highly sensitive and widely-spread method with no destructive impact, high excitation selectivity and the possibility to use in highly scattering media. The goal of this work was to assess a correlation of UV laser-induced fluorescence spectroscopy and laser Doppler flowmetry parameters, and a possibility to identify or to differentiate various types of pathological changes in tissues according to their autofluorescence spectra. Three groups of patients with diffuse (symptomatic) alopecia, androgenic alopecia, and focal alopecia have been tested. Each groups consisted of not less than 20 persons. The measurements have been done in the parietal and occipital regions of the sculls. We used the original automated spectrofluorimeter to record autofluorescence spectra, and standard laser Doppler flowmeter BLF-21 (Transonic Systems, Inc., USA) to analyze the basal levels of blood circulation. Our results show that UV LIFS accurately distinguishes the zones with different types of alopecia. We found high correlation of the basal levels of blood circulation and the integrated intensity of autofluorescence in the affected tissue.

  3. STUDY OF THERAPEUTIC COMPARISON OF TACROLIMUS 0.1% AND MINOXIDIL 2% IN ALOPECIA AREATA

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    Kallappa C. Herkal

    2013-07-01

    Full Text Available Introduction: Alopecia areata is a unique, idiopathic disease in which there is patchy hair loss. The variable and uncertain natural history of alopecia areata is accounting for the multiplicity of uncritical claims for a large variety of therapeutic procedures. Aim: to find the therapeutic comparison between tacrolimus 0.1% ointment and minoxidil 2% solution. Material and Methods: Patients attending skin out patient department in Navodaya medical college hospital and research centre, Raichur were screened and the consenting consecutive cases of Aopecia Areata (AA from December 2010 to November 2011 were chosen for study. There were 75 patients in the study. It is a randomized, single blind, intension to treat study. The eligible patients for the study were randomly allocated into two groups-Group A and Group B (38 in Group A and 37 in Group B. Patients in Group A were treated with 2% Minoxidi solution to be applied twice daily over the alopecia patch, where as Patients in Group B were treated with Tacrolimus 0.1% ointment applied twice daily. Patients were followed up at 2, 4, 6, 8, 10 and 12 weeks. Alopecia Grading Score (AGS was calculated at baseline and 12 weeks. Regrowth Score (RGS was calculated at 12 weeks. Results: Total 69 patients completed the study (35 in Group A and 34 in Group B. In our study RGS ≥ 3 was observed in 65.71% of patients treated with Tinoxidil 2% solution and 44.12% of patients treated with Tacrolimus 0.1% ointment. Conclusion: In our study Minoxidil 2% solution had better stimulatory effect on hair growth compared to Tacrolimus 0.1% ointment in the treatment of mild to moderate patchy alopecia areata. The combination treatment may yield a better clinical response than either of the agents used singly.

  4. Current status of treatments for alopecia areata%斑秃的治疗现状

    Institute of Scientific and Technical Information of China (English)

    马萍萍; 郭红卫; 史建强

    2014-01-01

    斑秃是一种累及生长期毛囊的免疫相关性疾病.斑秃的治疗主要是依据患者的年龄、疾病的严重程度及持续时间来选择合适的治疗方法,包括糖皮质激素、米诺地尔、免疫疗法、生物制剂及试验性治疗和疾病管理措施等,但至今尚无确切有效的治疗和预防的方法,有些疗法也没有系统的随机、对照试验证据,其治疗方面仍是一大挑战.目前认为,斑秃是一种毛囊免疫赦免破坏的自身免疫性疾病,免疫抑制可控制病情,进一步重建免疫状态成为斑秃治疗的理想观念.%Alopecia areata is a complex immune-mediated disease that targets anagen hair follicles.Treatment strategies are determined mainly according to patients' age,as well as the extent and duration of scalp involvement.Various therapeutic regimens have been described for alopecia areata,including corticosteroids,minoxidil,immunotherapy,biological agents,etc,but none of them is curative or preventive.Moreover,many of these therapeutic agents have not been subjected to randomized,controlled trials.The conquest of alopecia areata is still challenging.Now alopecia areata is considered to be an autoimmune disease with the loss of immune privilege in hair follicles.It is an ideal strategy to control alopecia areata through initial immunosuppression followed by reconstruction of the immune system.

  5. 斑秃的研究进展%Advances in alopecia areata

    Institute of Scientific and Technical Information of China (English)

    谭欢; 杨希川

    2014-01-01

    Alopecia areata is considered as a T-cell-mediated,hair follicle-targeted autoimmune disease.The gradual loss of protection provided by hair follicle immune privilege plays an important role in the pathogenesis of alopecia areata.It can be induced or triggered by psychiatric and psychological factors.Recently,at least eight domains have been identified to be associated with alopecia areata by a genome-wide association study (GWAS),which may provide a theoretical basis for the understanding of its pathogenesis and development of new therapeutic strategies.Now the pathogenesis of alopecia areata remains unclear,and available therapies are limited.To learn the epidemiology,etiology and treatment of alopecia areata may be beneficial to its management.%斑秃是一种由T淋巴细胞介导的针对毛囊的器官特异性自身免疫性疾病,正常毛囊的免疫赦免作用的破坏在其发病过程中起着重要作用.精神心理因素可使病情加重或反复.目前通过全基因组关联分析至少发现了8个与斑秃发病有关的基因区域,为更好地认识斑秃的发病机制和寻求新的治疗方法提供了遗传学的理论基础.斑秃的发病机制尚不完全清楚,了解斑秃的流行病学、病因及治疗方法对斑秃的处理有指导意义

  6. Frequency, severity and related factors of androgenetic alopecia in dermatology outpatient clinic: hospital-based cross-sectional study in Turkey*

    Science.gov (United States)

    Salman, Kubra Esen; Altunay, Ilknur Kivanc; Kucukunal, Nihal Asli; Cerman, Asli Aksu

    2017-01-01

    BACKGROUND Androgenetic alopecia (AGA) is a patterned hair loss occurring due to systemic androgen and genetic factors. It is the most common cause of hair loss in both genders. In recent years, many studies investigating the relation between systemic diseases and androgenetic alopecia presented controversial results. OBJECTIVES In this study we aimed to investigate the frequency of androgenetic alopecia, the presence of accompanying systemic diseases, the relation between body mass index and androgenetic alopecia severity and the association of hyperandrogenemia signs with androgenetic alopecia in patients who referred to our outpatient clinic. METHODS Patients who referred to our clinic between October 2013 and May 2014 were included in the study. Diagnosis of androgenetic alopecia was made upon clinical findings. Presence of seborrhea and acne in both genders, and hirsutism in women, were examined. Age, gender, smoking habit and alcohol consumption, age of onset of androgenetic alopecia, family history, accompanying systemic diseases and abnormalities of menstrual cycle were recorded. RESULTS 954 patients (535 women, 419 men) were included in the study. Androgenetic alopecia prevalence found was 67.1% in men and 23.9% in women. Androgenetic alopecia prevalence and severity were correlated with age in both genders (p=0,0001). Frequency of accompanying systemic diseases were not significantly different between patients with and without androgenetic alopecia (p=0,087), except for hypertension, which was significantly more frequent in men with androgenetic alopecia aged between 50 and 59 years. Study limitations: Despite the exclusion of other causes of alopecia, differentiation of Ludwig grade 1 AGA from telogen effluvium based on clinical features alone is difficult. CONCLUSIONS In our study the rate of androgenetic alopecia was found to be higher than the other studies made in Asian and Caucasian populations. PMID:28225954

  7. Study Of The Existence Of Neoantigens In Affected Hair Follicles Using Lymphocyte Transformation Test In Alopecia Areata And Healthy Persons

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    Saehi Nodeh A

    2004-07-01

    Full Text Available Background: Alopecia areata is a common, inflamatory and chronic disease of hair and nails, which in some cases result in growth inhibition and lose of hairs. Several factors such as genetic factors, autoimmunity, atopy, stress, fear etc, are known as effective factors in induction and severity of the disease, but the ethiology of this disease is not known exactly so far. Some evidences such as presence of an autoantibodies against hair follicules and infiltration of immunocompetent cells in affected areas of the disease lead that most investigators classify alopecia as autoimmune disease. In one investigation in immunology department of Tarbiat Modarres university concerning the humoral immunity in alopecia pathogenesis some evidences were found for the presences of a neoantigen in affected hair follicles. Since various studies indicates that cellular arm of the immune system is more important in alopecia areata pathogenesis, in this investigation we studied the existence of neoantigens in affected hair follicles using lymphocyte transformation test (LTT. Materials and Methods: The proliferation responses of peripheral blood mononuclear cells (MNC from alopecia patients and normal individuals were investigated against the follicular extracts of affected and normal hairs separately. Results: Our results indicate a non significant difference between proliferation responses of MNC’s from alopecia patients and normal controls against follicular extract of normal hairs. These responses were not significantly different against folliclar extracts of affected hairs as well. Regarding our results. Conclusion: We could not show the existence of a neoantigen in alopecia hair follicles, but the obtained results can not completely reject the role of a neoantigen in alopecia pathogenesis as well, because in LTT the responding cells are of memory type and these cells may be very low in peripheral blood. The immune response in this disease may be restricted

  8. Summary of traditional Chinese medicine in the treatment of alopecia areata%斑秃中医治法概要

    Institute of Scientific and Technical Information of China (English)

    陆熙铭; 陆文生

    2016-01-01

    This paper summarizes the clinical of traditional Chinese medicine for the treatment of alopecia areata, so as to provide reference for clinical treatment of alopecia areata.%本研究具体综述了中医药临床对于斑秃的治疗方法,以期为斑秃的临床治疗提供参考。

  9. Alopecia Areata: The Role of Stressful Events and an Estimate of Lifetime Risk in First-Degree Relatives

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    Khoshdel

    2016-02-01

    Full Text Available Background Alopecia areata (AA is a common disease in the military population; however, a few studies have calculated the lifetime risk of alopecia areata in first-degree relatives of patients as well as the impact of stress. Objectives The primary aim of this study was to calculate the lifetime risk of alopecia areata in first-degree relatives of index patients. The secondary aim of this study was to assess the role of stressful events in the onset/recurrence of disease. Patients and Methods One hundred and twenty-one patients with alopecia areata and their first-degree relatives, which included 597 subjects in addition to 119 controls, were studied. We considered a gender and age-matched control for each patient. They were investigated for the occurrence of stressful events within the previous six months before the onset/recurrence of the disease. Results More than twenty-six percent of patients had a positive family history, while 6.4 percent of first-degree relatives were affected by alopecia areata. Lifetime risks were estimated at 7.6% for parents, 9.9% for siblings, and 6.4% for children. Eighty-eight patients (73.9% experienced stressful events within six months prior to the onset or recurrences of alopecia areata, while 32 subjects (26.9% of the control group reported such events in the last six months (P value = 0.000. Conclusions Calculated lifetime risks can be used in genetic counseling. It appears that stressful events can be considered to be contributing factors in the development of alopecia areata. Also, according to our results, the role of stress in the recurrence of alopecia areata is more prominent than the primary development of the disease.

  10. Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men.

    Science.gov (United States)

    Blumeyer, Anja; Tosti, Antonella; Messenger, Andrew; Reygagne, Pascal; Del Marmol, Veronique; Spuls, Phyllis I; Trakatelli, Myrto; Finner, Andreas; Kiesewetter, Franklin; Trüeb, Ralph; Rzany, Berthold; Blume-Peytavi, Ulrike

    2011-10-01

    Androgenetic alopecia is the most common hair loss disorder, affecting both men and women. Initial signs of androgenetic alopecia usually develop during teenage years leading to progressive hair loss with a pattern distribution. Moreover, its frequency increases with age and affects up to 80 % Caucasian men and 42 % of women. Patients diagnosed with androgenetic alopecia may undergo significant impairment of quality of life. Despite the high prevalence and the variety of therapeutic options available, there have been no national or international evidence-based guidelines for the treatment of androgenetic alopecia in men and women so far. Therefore, the European Dermatology Forum (EDF) initiated a project to develop an evidence-based S3 guideline for the treatment of andro-genetic alopecia. Based on a systematic literature research the efficacy of the currently available therapeutic options was assessed and therapeutic recommendations were passed in a consensus conference. The purpose of the guideline is to provide dermatologists as well as general practitioners with an evidence-based tool for choosing an efficacious and safe therapy for patients with androgenetic alopecia.

  11. Comparison of androgenic alopecia distribution among type 2 diabetes and healthy women in Isfahan city: a brief report

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    Fariba Jafari

    2014-09-01

    Methods: This is a case-control study. Case and control groups were selected from type II diabetes and healthy women respectively that were refered to clinics of Alzahra, Noor and Amin Hospitals in Isfahan City, Iran in 2011. Participants were selected based on random sampling. Sample size was estimated 141 subjects in each group. Participants were visited by doctor and severity of androgenic alopecia was determined based on Ludwish criteria. Data were analyzed with SPSS software and 2 test. P<0.05 was considered as significant. Results: Mean age and body mass index were 58.96±12.8 year and 25.6±4.15 kg/m2 respectively in whole population. Findings not show any significant association between type II diabetes and androgenic alopecia (P<0.05. Comparison of distribution of alopecia severity according to Ludwish criteria separately showed similar result. In addition to, there was not any significant relationship between diabetes and alopecia after adjusting with body mass index as confounding factor (P<0.05. Conclusion: In the present study, there was not any significant relationship between type II diabetes and androgenic alopecia among diabetes and healthy women. However, more researches need to investigate this relationship in both gender and assess insulin resistant indices as homeostasis model assessment-estimated insulin resistance and androgenic alopecia.

  12. Incidental Syringomas of the Scalp in a Patient with Scarring Alopecia

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    Kristyn Deen

    2015-07-01

    Full Text Available Syringomas are benign adnexal neoplasms of eccrine lineage, which occur most commonly in the periorbital region in middle-aged females. These cutaneous lesions rarely occur on the scalp, are typically asymptomatic and are predominantly of cosmetic significance. Involvement of the scalp may be indistinguishable from that of scarring alopecia. We present an unusual case of clinically inapparent syringomas occurring on the scalp of a 56-year-old female with alopecia who was subsequently diagnosed with lichen planopilaris after repeated scalp biopsy. In patients with unexplained hair loss, or in cases that are refractive to treatment, clinicians should perform scalp biopsy to exclude the diagnosis of rare neoplastic lesions like syringomas and to diagnose associated conditions.

  13. Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle?

    Science.gov (United States)

    Haslam, Iain S; Pitre, Aaron; Schuetz, John D; Paus, Ralf

    2013-11-01

    Currently, efficacious treatments for chemotherapy-induced alopecia (hair loss) are lacking, and incidences of permanent hair loss following high-dose chemotherapy are on the increase. In this article, we describe mechanisms by which the pharmacological defense status of the hair follicle might be enhanced, thereby reducing the accumulation of cytotoxic cancer drugs and preventing or reducing hair loss and damage. We believe this could be achieved via the selective increase in ATP-binding cassette (ABC) transporter expression within the hair follicle epithelium, following application of topical agonists for regulatory nuclear receptors. Clinical application would require the development of hair follicle-targeted formulations, potentially utilizing nanoparticle technology. This novel approach has the potential to yield entirely new therapeutic options for the treatment and management of chemotherapy-induced alopecia, providing significant psychological and physical benefit to cancer patients.

  14. 脂溢性秃发的病因探讨%Aetiologic studies of alopecia seborrhoeica

    Institute of Scientific and Technical Information of China (English)

    张怡明; 张耀龙; 倪盛瑛

    2001-01-01

    目的探讨脂溢性秃发(脂秃)的病因。方法通过患者秃发区皮肤组织免疫组化定位染色法,进行性激素受体检测,同时测定血清中微量元素Fe、Cu、Zn及超氧化物歧化酶(SOD)、丙二醛(MDA),以及对问诊调查进行比较分析。结果脂秃患者秃发区雄激素受体(AR)表达明显高于正常人,但与家族史无关,约35 %脂秃患者秃发区头皮组织无AR阳性表达。脂秃患者血清中Fe元素及SOD的含量比正常人明显减少。100 %脂秃患者与两个以上相关因素有关。结论脂秃是一种多因素的疾病。%Objective  To investigate aetiology of alopecia seborrhoeica. Methods Immunocytochemical localization of androqenic receptor(AR) was performed in the skin with baldness, and serum Fe,Cu,Zn,SOD and MDA detected, together with an interrogation. Results  Expression of androgenic receptor in alopecia was higher than that in normal controls.There was no correlation between the positive expression of AR and familial history. No expression of AR was found in about 35 % of the patrents.More than two factors involved in the pathogenesis of alopecia seborrhoeia.. Conclusion  Alopecia seborrhoeica is a disease entity related to multple pathogenic factors.

  15. The effectiveness of finasteride and dutasteride used for 3 years in women with androgenetic alopecia

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    Ids H Boersma

    2014-01-01

    Full Text Available Background: The effectiveness of finasteride and dutasteride in women with androgenetic alopecia has been the subject of debate. Aim: To evaluate the effectiveness of finasteride and dutasteride on hair loss in women with androgenetic alopecia over a period of 3 years. Methods: From a database containing systematically retrieved data on 3500 women treated for androgenetic alopecia between 2002 and 2012 with finasteride 1.25 mg or dutasteride 0.15 mg, a random sample stratified for age and type of medication was taken to yield 30 women in two age categories: below and above 50 years, and for both medications. Hair thickness of the three thinnest hairs was measured from standardized microscopic images at three sites of the scalp at the start of the treatment and after 3 years of continuous medication intake. The macroscopic images were evaluated independently by three European dermatologists/hair experts. The diagnostic task was to identify the image displaying superior density of the hair. Results: Both age categories showed a statistically significant increase in hair thickness from baseline over the 3-year period for finasteride and dutasteride (signed rank test, P = 0.02. Hair thickness increase was observed in 49 (81.7% women in the finasteride group and in 50 (83.3% women in the dutasteride group. On average, the number of post-treatment images rated as displaying superior density was 124 (68.9% in the finasteride group, and 118 (65.6% in the dutasteride group. Dutasteride performed statistically significantly better than finasteride in the age category below 50 years at the central and vertex sites of the scalp. Conclusions: Finasteride 1.25 mg and dutasteride 0.15 mg given daily for 3 years effectively increased hair thickness and arrested further deterioration in women with androgenetic alopecia.

  16. CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice.

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    Lixin Wang

    Full Text Available Corticotropin-releasing factor (CRF signaling pathways are involved in the stress response, and there is growing evidence supporting hair growth inhibition of murine hair follicle in vivo upon stress exposure. We investigated whether the blockade of CRF receptors influences the development of hair loss in CRF over-expressing (OE-mice that display phenotypes of Cushing's syndrome and chronic stress, including alopecia. The non-selective CRF receptors antagonist, astressin-B (5 µg/mouse injected peripherally once a day for 5 days in 4-9 months old CRF-OE alopecic mice induced pigmentation and hair re-growth that was largely retained for over 4 months. In young CRF-OE mice, astressin-B prevented the development of alopecia that occurred in saline-treated mice. Histological examination indicated that alopecic CRF-OE mice had hair follicle atrophy and that astressin-B revived the hair follicle from the telogen to anagen phase. However, astressin-B did not show any effect on the elevated plasma corticosterone levels and the increased weights of adrenal glands and visceral fat in CRF-OE mice. The selective CRF₂ receptor antagonist, astressin₂-B had moderate effect on pigmentation, but not on hair re-growth. The commercial drug for alopecia, minoxidil only showed partial effect on hair re-growth. These data support the existence of a key molecular switching mechanism triggered by blocking peripheral CRF receptors with an antagonist to reset hair growth in a mouse model of alopecia associated with chronic stress.

  17. Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia

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    Hajheydari Zohreh

    2009-01-01

    Full Text Available Background: Finasteride, a type P-selective 5a-reductase inhibitor, as a causative agent of decreasing dihydroxy testestrone (DHT level, is effective in the treatment of male androgenic alopecia. Aim: We compared the local and oral finasteride in the treatment of androgenic alopecia. Method: This is a double blind, randomized clinical trial study of 45 male patients, who were referred with alopecia to the private clinics and departments in Boo-Ali Sina Hospital, in Sari. Patients with male androgenic alopecia were selected according to the history and physical examinations. The patients were randomly divided into two: topical finasteride (A and oral finasteride (B groups. Topical finasteride group (A received a topical gel of 1% finasteride and placebo tablets, while the oral finasteride group (B received finasteride tablets (1 mg and gel base (without drug as placebo for 6 months. The patients were followed by clinical observation and recording of side effects prior to the treatment and at the end of first week, and then by a monthly follow-up. The size of bald area, total hair count, and terminal hair were studied. Data were analyzed by descriptive and Chi-square statistical test. Results: The mean duration of hair loss was 18.8±23.10 months. Each month the terminal hair, size of bald area and hair count between the two groups were compared. There were no significant differences between the two groups as a viewpoint of hair thickness, hair counts and the size of bald area. Serial measurements indicated a significant increase in hair counts and terminal hair counts between the two groups. Conclusions: The results of this study showed that the therapeutic effects of both finasteride gel and finasteride tablet were relatively similar to each other.

  18. Evaluation of 25 hydroxy vitamin D3 levels in patients with alopecia areata

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    Atiye Oğrum

    2015-03-01

    Full Text Available Background and Design: Current studies link a possible relationship between vitamin D deficiency and many autoimmune diseases. Alopecia areata(AA is a frequent autoimmune dermatological disease. The aim of this study was to investigate the relationship between vitamin D levels and alopecia areata; a frequent autoimmune dermatological disease. Materials and Methods: The 25 hydroxyvitamin D (25 OH D levels of 40 patients with alopecia areata and age, gender and skin phototype matched healthy controls were evaluated. Serum 25 OH D was measured in all subjects, grouped as normal/sufficient (> 30 ng/ml, insufficient (15-30 ng/ml and deficient (0,05. In both groups 97,5% of patients had 25 OH D levels under normal range. Conclusion: Vitamin D levels of patients with AA was similar with the control group This similarity may suggest that a connection between vitamin D and AA does not exist. However, it may also indicate that the relationship between AA and Vitamin D is not via the level but receptor (number and / or structure of vitamin D.

  19. Use of body and beard donor hair in surgical treatment of androgenic alopecia

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    Arvind Poswal

    2013-01-01

    Full Text Available Objectives: Follicular unit transplant is a widely used surgical treatment for androgenic alopecia. However, for patients with extensive hair loss (Norwood 5 and above, scalp donor hair are not sufficient to cover all areas of baldness. This study aims to assess suitability of beard and body donor hair when transplanted to the scalp. Materials and Methods: In 35 male patients having varying degrees of androgenic alopecia, body and beard donor hair were extracted by follicular unit extraction method (under local anesthesia. They were transplanted in different locations of the scalp. Follow-up was carried out at various intervals (6 months to 2 years. The hairs were observed for colour, curl and calibre. Results: In all the patients, there was no change in the colour, curl or calibre of the transplanted body/beard hair. They maintained the same characteristics as in their original location. Conclusion: Body and beard hair can be used as additional donor resource for treating androgenic alopecia. These hairs, however, do not change their colour, curl, and shaft diameter (calibre. Thus, proper planning is a must when using the different types of donor hair for transplanting.

  20. EFFICACY OF LOW LEVEL LASER THERAPY IN THE TREATMENT OF ALOPECIA AREATA

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    Nermeen Mohamed Abdelhalim. PhD PT

    2014-04-01

    Full Text Available Background: Alopecia areata is a chronic inflammatory disease which affects the hair follicles and sometimes the nails. Purpose: The purpose of this study was to evaluate the efficacy of low level laser therapy in the treatment of alopecia areata of the scalp. Method: Twenty three patients (14 male and 9 female had 2 or more patches of the scalp, one patch was left for comparison as a control patches. The age ranged from 22 to 39 years with 30 ± 6.09 years mean. The study patches received12 sessions of low level laser therapy for 2 minutes/cm² of the affected patch with the dose of 1.5 J/cm². Each subject received 3 sessions per week for one month. Hair count, the hairs number within the one square centimeter space and Visual analog scale of hair loss were assessed pre-treatment, post-treatment and follow-up time (2 months. Results: showed significant improvement in the two outcomes of study patches (p 0.005. Conclusion: Using low level laser therapy was effective in the treatment of alopecia areata of the scalp.

  1. Health-Related Quality of Life (HRQoL) in alopecia areata patients-a secondary analysis of the National Alopecia Areata Registry Data.

    Science.gov (United States)

    Shi, Qiuling; Duvic, Madeleine; Osei, Joyce S; Hordinsky, Maria K; Norris, David A; Price, Vera H; Amos, Christopher I; Christiano, Angela M; Mendoza, Tito R

    2013-12-01

    Alopecia areata (AA) is a nonscarring and recurrent disease characterized by hair loss that may significantly affect patient health-related quality of life (HRQoL). Given the lack of reliable and accurate reporting of HRQoL status in patients with AA, we analyzed data from 532 AA patients from the National Alopecia Areata Registry whose registry record included HRQoL assessments using three validated instruments: Skindex-16, brief version of the Fear of Negative Evaluation Scale, and Dermatology Life Quality Index. The mean HRQoL scores were compared with previously reported HRQoL levels from healthy controls and patients with other skin diseases. Two-step cluster analysis of Skindex-16 scales divided patients into two groups: 481 (57%) with good HRQoL and 361 (43%) with poor HRQoL. Multivariate logistic regression modeling revealed a set of risk factors for poor HRQoL: age HRQoL status of AA patients and may guide patient care in the future.

  2. 系统性红斑狼疮脱发的研究进展%Alopecia in systemic lupus erythematosus

    Institute of Scientific and Technical Information of China (English)

    叶艳婷; 章星琪

    2011-01-01

    Alopecia is a common clinical presentation of systemic lupus erythematosus (SLE). There are various types of alopecia in SLE, such as lupus hair, non-scarring patchy alopecia, diffuse telogen effluvium and patchy scarring alopecia in discoid lupus erythematosus (DLE). These types of alopecia differ from each other in clinical and histopathological manifestations. Alopecia in patients with SLE may be correlated to the disease activity. The pathogenesis of alopecia in SLE is not fully understood, and may be associated with the changes in local microenvironment induced by autoimmune inflammation and vasculitis, hair nutrient deficiency and disturbances of hair follicle cycle.%脱发是SLE常见的临床表现之一。SLE脱发可表现为多种类型,如狼疮发、非瘢痕性斑状脱发、弥漫性休止期脱发、盘状红斑狼疮型脱发等,不同类型的脱发在临床表现和组织病理学方面有其各自的特点。SLE脱发与疾病活动性有一定的相关性。目前SLE脱发的发病机制尚未明确,自身免疫性炎症和血管炎造成的局部微环境的改变、毛发营养不良和毛囊周期失调均有可能参与其中。

  3. Advances in the treatment of alopecia areata%斑秃治疗进展

    Institute of Scientific and Technical Information of China (English)

    惠云; 王千秋; 张国毅

    2012-01-01

    Alopecia areata is a kind of common benign non-scarring hair loss severely affecting patient's appearance.Traditional therapies include topical or systemic corticosteroids as well as drugs promoting hair growth such as minoxidil.With new insights into the pathogenesis of alopecia areata,some novel treatment modalities,such as immunomodulators,biologics,308-excimer laser,photochemotherapy with psoralens and ultraviolet A (PUVA),and so on,have been gradually introduced into the treatment of alopecia areata.The clinical application of these new modalities is limited because of their side effects and the lack of evidences from large-scale randomized controlled trials,however,they have provided a useful clue for the treatment of alopecia areata.To target the pathogenesis and minimize adverse effects will be the focus of future research in alopecia areata treatment.%斑秃是一种皮肤科常见的良性、以非瘢痕性脱发为主要表现的疾病,严重影响美观.传统的治疗方法基于局部或系统应用糖皮质激素或米诺地尔等促毛发生长药物.随着对斑秃发病机制研究的不断深入,出现了一些新的尝试性的治疗方法,如免疫调节剂、新型生物制剂、308 nm准分子激光、PUVA 等,由于这些疗法缺乏大规模随机对照试验的证据支持并存在较多不良反应,因此在临床上的应用受到限制,但为以后开发新型治疗药物提供了有益的思路.今后斑秃治疗研究的热点将是针对发病机制的靶向治疗并最大限度减少不良反应.

  4. Prevalence of anti-gliadin antibody in patients with alopecia areata: a case-control study

    Directory of Open Access Journals (Sweden)

    Hallaji Z

    2011-03-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Alopecia areata, a non-cicatricial form of hair loss, is believed to be an immunologic response that targets hair follicles. Genetic background is important in the pathogenesis of this disorder, although some evidence point to the role of melanocytic antigens. There are some reports on the relationship between alopecia areata and celiac disease. The aim of the present study was to identify antigliadin antibodies in patients with alopecia areata. "n"nMethods: Fifty patients, aged 2.5-50 years, with alopecia areata presenting to the dermatology clinic of Razi Educational Hospital in Tehran, Iran, and fifty healthy individuals, aged 5-48 were matched and enrolled in the study. After signing an informed consent form, blood samples (10 ml clotted blood were obtained from the participants and sent to referral laboratory for the presence of antigliadin IgA and IgG antibodies. Concentrations of antibodies were measured by ELISA through a full automatic ELISA reader. The data were analyzed statistically."n"nResults: The study included 29(58% male and 21(42% female patients with a mean age of 24.6 years. The control group included 29(58% male and 21(42% female individuals with a mean age

  5. Padrão dermatoscópico das alopecias cicatriciais causadas por lúpus eritematoso discoide e líquen plano pilar Dermoscopy patterns of cicatricial alopecia resulting from discoid lupus erythematosus and lichen planopilaris

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    Bruna Duque Estrada

    2010-04-01

    Full Text Available FUNDAMENTOS: A dermatoscopia é método importante de diagnóstico de doenças melanocíticas benignas e malignas. Recentemente, o uso desse método tem demonstrado grande ajuda também no diagnóstico e acompanhamento das alopecias. OBJETIVO: Descrever e demonstrar os achados dermatoscópicos de pacientes com quadros clínicos e histopatológicos de alopecia cicatricial. MÉTODOS: Estudo transversal descritivo em que foram selecionados, pelos achados clínicos e histopatológicos do couro cabeludo, 14 pacientes com alopecia cicatricial, sendo quatro casos de líquen plano pilar clássico, cinco casos de alopecia fibrosante frontal e cinco com lúpus eritematoso discoide. Os pacientes foram avaliados com videodermatoscópio e dermatoscópio manual por três examinadores diferentes, de forma independente. Os aumentos variaram de 10 a 70 vezes. RESULTADOS: Foram achados predominantes no lúpus eritematoso discoide placas brancas, capilares arboriformes, tampões ceratósicos e áreas com diminuição dos óstios foliculares; no líquen plano pilar clássico, escamas perifoliculares, pontos brancos e diminuição de óstios foliculares; na alopecia fibrosante frontal, diminuição de óstios foliculares, escama e eritema perifolicular, além de capilares arboriformes. As estruturas azul-acinzentadas, demonstradas neste estudo, não foram descritas na literatura. CONCLUSÕES: O uso da dermatoscopia na avaliação clínica das alopecias ajudou a estabelecer elementos semióticos, melhorou a capacidade de diagnóstico em relação à simples inspeção e revelou novas características das alopecias cicatriciais.BACKGROUND: Dermoscopy is an important tool for the diagnosis of benign and malignant melanocytic diseases. Recently, this method has also been found to be extremely useful in the diagnosis and follow-up of alopecias. OBJECTIVE: The objective of this study was to describe dermoscopic findings in patients with clinical and histopathological

  6. Study of Th1/Th2 balance in peripheral blood mononuclear cells of patients with alopecia areata.

    Science.gov (United States)

    Sadeghi, Soha; Sanati, Mohammad Hossein; Taghizadeh, Morteza; Mansouri, Parvine; Jadali, Zohreh

    2015-09-01

    Alopecia areata represents an autoimmune pathological process driven primarily by cellular aberrations contained within the immune system, which activates various humoral and cellular elements of the immune response. The aim of this study was to determine the mRNA expression levels of T-bet and GATA-3 as potential inducers of T helper (Th)1 and Th2 differentiation, respectively, as well as Th1(IFN-γ) and Th2(IL-4) cytokine mRNA expression in patients with alopecia areata. Using real-time reverse transcriptase PCR (RT-PCR), the relative amounts of T-bet, GATA-3, IFN-γ, and IL-4 mRNA transcripts were determined in PBMCs from 20 Iranian patients with alopecia areata and compared with those of 20 healthy control subjects. In comparison with the normal group, T-bet and IFN-γ mRNA expression levels were significantly up-regulated in the alopecia areata patients, while GATA-3 and IL-4 mRNA expression levels were down-regulated. Notably, positive correlation (P < 0.05) was found between IFN-γ and T-bet levels in patients and controls. In addition, significant positive correlations existed between GATA-3 and IL-4 (P < 0.05). These results indicate that a Th1/Th2 imbalance exists in alopecia areata, and it may be implicated in the pathogenesis of disease.

  7. PUVA treatment of alopecia areata partialis, totalis and universalis: audit of 10 years` experience at St John`s Institute of Dermatology

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    Taylor, C.R.; Hawk, J.L.M. [St Thomas` Hospital, London (United Kingdom). St John`s Institute of Dermatology

    1995-12-01

    Our 10-year experience with PUVA treatment for alopecia areata, partialis, totalis and universalis was retrospectively reviewed using charts and follow-up questionnaires for 70 patients at St John`s Institute of Dermatology. In all cases, several previous therapies were judged to be unsatisfactory prior to starting PUVA, and many cases were already deemed clinically refractory prior to referral for PUVA. If cases of vellus hair growth are excluded, and those who lost their PUVA-induced regrowth rapidly on follow-up, the effective success rate was at best 6.3% for alopecia areata partialis, 12.5% for alopecia areata totalis and 13.3% for alopecia areata universalis. We affirm that PUVA is generally not an effective treatment for alopecia areata. (Author).

  8. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia

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    Shamma RN

    2014-11-01

    Full Text Available Rehab Nabil Shamma, Mona Hassan AburahmaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptAbstract: Spironolactone (SL is a US Food and Drug Administration-approved drug for the treatment of hypertension and various edematous conditions. SL has gained a lot of attention for treating androgenic alopecia due to its potent antiandrogenic properties. Recently, there has been growing interest for follicular targeting of drug molecules for treatment of hair and scalp disorders using nanocolloidal lipid-based delivery systems to minimize unnecessary systemic side effects associated with oral drug administration. Accordingly, the objective of this study is to improve SL efficiency and safety in treating alopecia through the preparation of colloidal nanostructured lipid carriers (NLCs for follicular drug delivery. SL-loaded NLCs were prepared by an emulsion solvent diffusion and evaporation method using 23 full factorial design. All of the prepared formulations were spherical in shape with nanometric size range (215.6–834.3 nm and entrapment efficiency >74%. Differential scanning calorimetry thermograms and X-ray diffractograms revealed that SL exists in amorphous form within the NLC matrices. The drug release behavior from the NLCs displayed an initial burst release phase followed by sustained release of SL. Confocal laser scanning microscopy confirmed the potential of delivering the fluorolabeled NLCs within the follicles, suggesting the possibility of using SL-loaded NLCs for localized delivery of SL into the scalp hair follicles.Keywords: spironolactone, androgenic alopecia, nanostructured lipid carriers, follicular targeting, confocal laser scanning microscopy

  9. Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.

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    Fabian Runkel

    Full Text Available BACKGROUND: Inositol 1,4,5trisphosphate (IP(3 and diacylglycerol (DAG are important intracellular signalling molecules in various tissues. They are generated by the phospholipase C family of enzymes, of which phospholipase C delta (PLCD forms one class. Studies with functional inactivation of Plcd isozyme encoding genes in mice have revealed that loss of both Plcd1 and Plcd3 causes early embryonic death. Inactivation of Plcd1 alone causes loss of hair (alopecia, whereas inactivation of Plcd3 alone has no apparent phenotypic effect. To investigate a possible synergy of Plcd1 and Plcd3 in postnatal mice, novel mutations of these genes compatible with life after birth need to be found. METHODOLOGY/PRINCIPAL FINDINGS: We characterise a novel mouse mutant with a spontaneously arisen mutation in Plcd3 (Plcd3(mNab that resulted from the insertion of an intracisternal A particle (IAP into intron 2 of the Plcd3 gene. This mutation leads to the predominant expression of a truncated PLCD3 protein lacking the N-terminal PH domain. C3H mice that carry one or two mutant Plcd3(mNab alleles are phenotypically normal. However, the presence of one Plcd3(mNab allele exacerbates the alopecia caused by the loss of functional Plcd1 in Del(9olt1Pas mutant mice with respect to the number of hair follicles affected and the body region involved. Mice double homozygous for both the Del(9olt1Pas and the Plcd3(mNab mutations survive for several weeks and exhibit total alopecia associated with fragile hair shafts showing altered expression of some structural genes and shortened phases of proliferation in hair follicle matrix cells. CONCLUSIONS/SIGNIFICANCE: The Plcd3(mNab mutation is a novel hypomorphic mutation of Plcd3. Our investigations suggest that Plcd1 and Plcd3 have synergistic effects on the murine hair follicle in specific regions of the body surface.

  10. A CLINICAL AND INVESTIGATORY STUDY OF ALOPECIA AREATA WITH SPECIAL REFERENCE TO SYSTEMIC ASSOCIATIONS IN 100 PATIENTS

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    Guruprasad

    2015-10-01

    Full Text Available BACKGROUND: Alopecia areata is an autoimmune condition with a worldwide occurrence. It usually presents as patchy, non - scarring hair loss. There is a paucity of clinical data in Indians. OBJECTIVES: To study the clinical profile and to know the association with vario us systemic and dermatological disorders. METHODS: A descriptive study was conducted on 100 cases of alopecia areata after taking informed consent, over a period of 16 months from December 2012 to April 2014. A detailed history of the patient regarding ass ociated systemic and dermatological disorders and various autoimmune disorders were documented, relevant investigations were done. RESULTS: Incidence of alopecia areata in patients attending dermatology out - patient department was 1.7%. There was slight mal e preponderance (51%. Most common age group involved was 20 - 40y rs. (47%. Alopecia areata was higher among low socioeconomic group (62%. Recurrences of AA was noted in 14% of cases. Stress acting as triggering factor in 12%. Pregnancy and pos tpartum accounted for 4% of cases. Atopic dermatitis was noted in 1%, seborrheic dermatitis was noted in 1%, lichen planus was noted in 2%, psoriasis noted in 1% cases. Average age of onset of alopecia areata in atopics was 7.9 years. Occiput was the most common site accounting for 39.3% of cases. Nail pitting was noted in 7% of cases. In 2 cases 20 nail dystrophy was noted. Patchy type was the most common type of alopecia seen in 73% of patients. As per IKEDAS classification - 71% cases belonged to common type, 18% to atopic type, 5% to pre hypertensive, 6% to autoimmune type. Bronchial asthma was noted in 3%, Diabetes mell itu s in 5%, hypothyroidism noted in 12% of cases.

  11. Topical adenosine increases the proportion of thick hair in Caucasian men with androgenetic alopecia.

    Science.gov (United States)

    Iwabuchi, Tokuro; Ideta, Ritsuro; Ehama, Ritsuko; Yamanishi, Haruyo; Iino, Masato; Nakazawa, Yosuke; Kobayashi, Takashi; Ohyama, Manabu; Kishimoto, Jiro

    2016-05-01

    Adenosine is an effective treatment for androgenetic alopecia (AGA) in Japanese men and women. Adenosine exerts its effects by significantly increasing the proportion of thick hair. In this study, we assessed the clinical outcome of adenosine treatment for 6 months in 38 Caucasian men. The change in proportion of thick hair (≥60 μm) compared with baseline in the adenosine group was significantly higher than that in the placebo group (P thick hair in Caucasian men with AGA as well as in Japanese men and women.

  12. Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata.

    Science.gov (United States)

    d'Ovidio, Roberto; Vessio, Margherita; d'Ovidio, Francesco Domenico

    2013-04-01

    Current observations link vitamin D deficiency to many autoimmune diseases. There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms. Our results demonstrate the presence of insufficiency of 25-hydroxyvitamin D (25OH-D) in many patients with various clinical forms, correlated with the expected increase of the values of Parathyroid Hormone (PTH). This could suggest the possible clinical use of vitamin D in the management of this frustrating disease.

  13. An ectodermal dysplasia syndrome of alopecia, onychodysplasia, hypohidrosis, hyperkeratosis, deafness and other manifestations.

    Science.gov (United States)

    Freire-Maia, N; Cat, I; Raponegaidzinski, R

    1977-01-01

    A girl is reported with a hitherto apparently undescribed ectodermal dysplasia syndrome. The main findings include: alopecia, onychodysplasia, hypohidrosis, sensorineural deafness, skin with a tan color and hyperkeratosis (involving also plams and soles), unusual facies (with slight auricle and nose abnormalities), pectus excavatum, severe hyperopia, EEG abnormalities, and retarded bone age. The patient also presents mongoloid palpebral slanting, narrow palpebral fissures, bilateral esotropia, photophobia and dermatoglyphics with extensive ridge dissociation. The etiology is unknown but presumed to be genetic, possibly due to the homozygous state of an autosomal recessive mutation.

  14. Androgenetic, diffuse and senescent alopecia in men: practical evaluation and management.

    Science.gov (United States)

    Torres, Fernanda

    2015-01-01

    Male baldness is the most common diagnosis in men that present with hair loss. It is a genetically determined condition that is clearly an androgen-dependent trait, mainly driven by dihydrotestosterone action on the hair follicles, leading to miniaturization. Although in general this condition is socially accepted as a natural process in a man's life, for some individuals it might significantly impact quality of life, reducing self-esteem and increasing stress. This chapter encompasses the most important aspects of the practical evaluation (clinical features, trichoscopy, trichogram, histopathology, relevant blood tests) and management of male baldness, diffuse baldness and senescent alopecia.

  15. S1 guideline for diagnostic evaluation in androgenetic alopecia in men, women and adolescents.

    Science.gov (United States)

    Blume-Peytavi, U; Blumeyer, A; Tosti, A; Finner, A; Marmol, V; Trakatelli, M; Reygagne, P; Messenger, A

    2011-01-01

    Androgenetic alopecia (AGA) is the most common hair loss disorder, affecting both men and women. Due to the frequency and the often significant impairment of life perceived by the affected patients, competent advice, diagnosis and treatment is particularly important. As evidence-based guidelines on hair disorders are rare, a European consensus group was constituted to develop guidelines for the diagnostic evaluation and treatment of AGA. This S1 guideline for diagnostic evaluation of AGA in men, women and adolescents reviews the definition of AGA and presents expert opinion-based recommendations for sex-dependent steps in the diagnostic procedure.

  16. Obliteration of alopecia by hair-lifting: a new concept and technique.

    Science.gov (United States)

    Blanchard, G; Blanchard, B

    1977-09-01

    A new concept and technique of treatment of male-pattern alopecia are described. The concept is to remove, in serial stages, segments of skin that measure about 3 cm by 7 to 10 cm from the bald area of an alopecic scalp, and to raise the remaining hairy portion into the previously bald area.The technique consists of undermining the skin in the normal plane of cleavage between the galea and the sub-aponeurotic loose connective tissue after each removal of bald skin and "lifting" of hairy skin into the operative defects as they are obliterated by primary closure. By this method, which we call hair-lifting, the patient benefits also from an associated partial face-lift. Whatever remains of baldness after as much hair-lifting as feasible has been performed, is filled with "punch" grafts or free or pedicled strips. Each stage of the procedure is done under local anesthesia. The entire procedure is particularly suitable for tonsure baldness in men and even in the skull-cap type of androgenic alopecia in women.

  17. Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia.

    Science.gov (United States)

    Gelfuso, Guilherme Martins; Gratieri, Tais; Delgado-Charro, M Begoña; Guy, Richard H; Vianna Lopez, Renata Fonseca

    2013-05-01

    Although minoxidil (MX) is a drug known to stimulate hair growth, the treatment of androgenic alopecia could be improved by delivery strategies that would favor drug accumulation into the hair follicles. This work investigated in vitro the potential of iontophoresis to achieve this objective using MX sulfate (MXS), a more water-soluble derivative of MX. Passive delivery of MXS was first determined from an ethanol-water solution and from a thermosensitive gel. The latter formulation resulted in greater accumulation of MXS in the stratum corneum (skin's outermost layer) and hair follicles and an overall decrease in absorption through the skin. Anodal iontophoresis of MXS from the same gel formulation was then investigated at pH 3.5 and pH 5.5. Compared with passive delivery, iontophoresis increased the amount of drug reaching the follicular infundibula from 120 to 600 ng per follicle. In addition, drug recovery from follicular casts was threefold higher following iontophoresis at pH 5.5 compared with that at pH 3.5. Preliminary in vivo experiments in rats confirmed that iontophoretic delivery of MXS facilitated drug accumulation in hair follicles. Overall, therefore, iontophoresis successfully and significantly enhanced follicular delivery of MX suggesting a useful opportunity for the improved treatment of alopecia.

  18. Psychiatric morbidity and quality of life in skin diseases: A comparison of alopecia areata and psoriasis

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    Sagar B Karia

    2015-01-01

    Full Text Available Background: Alopecia areata (AA and psoriasis are associated with various psychiatric comorbidities. Both greatly affect the quality of life (QOL of patients and psychiatric comorbidities can further worsen it. Thus there is need to recognise psychiatric comorbidities and treat them in these patients. Aims: To determine the psychiatric morbidity and the QOL in these patients to study the factors affecting them. Methodology: 50 patients each of psoriasis and AA were included. 50 people accompanying these patients served as control group. They were diagnosed for psychiatric disorders by clinical interview. Scales used were severity of alopecia tool for AA, psoriasis area and severity index for psoriasis, WHO-QOL scale, Hamilton Rating Scale for anxiety and depression. Results: 22% and 38% patients in AA and psoriasis group respectively suffered from psychiatric disorder, depression was present in 18% and 24% of patients and 4% and 12% had anxiety disorders in respective groups. The control group had only 6% of psychiatric comorbidities. QOL scores had negative correlation with Hamilton-A, Hamilton-D and severity of psoriasis scores and they were statistically significant but not with severity of AA. Conclusion: Thus AA and psoriasis patients had more prevalence of psychiatric comorbidities and it had bearing on their QOL.

  19. α1 -AR agonist induced piloerection protects against the development of traction alopecia.

    Science.gov (United States)

    Goren, Andy; Shapiro, Jerry; Sinclair, Rodney; Kovacevic, Maja; McCoy, John

    2016-05-01

    Traction alopecia is hair loss that occurs after persistent pulling (e.g., during cosmetic procedures) on the roots of hair over time. Unlike plucking, which is painful, persistent pulling may go unnoticed until a patient presents with either bald spots or diffuse telogen shedding. Each hair follicle in the scalp contains an arrector pili muscle that, when contracted, erects the hair. The smooth muscle in the arrector pili expresses α1 adrenergic receptors (α1 -AR). As such, we hypothesized that contraction of the arrector pili muscle via an α1 -AR agonist would increase the threshold of force required to pluck hair during cosmetic procedures. Female subjects, ages 18-40, were recruited to study the effect of topically applied phenylephrine, a selective α1 -AR agonist, on epilation force and hair shedding during cosmetic procedures. In our blinded study, 80% of subjects demonstrated reduced shedding on days using phenylephrine compared to days using a placebo solution. The average reduction in hair loss was approximately 42%. In addition, the force threshold required for epilation increased by approximately 172% following topical phenylephrine application. To our knowledge this is the first study demonstrating the utility of α1 -AR agonists in the treatment of traction alopecia and hair shedding during cosmetic procedures.

  20. The Frequency of Autoimmune Thyroid Disease in Alopecia Areata and Vitiligo Patients

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    Gulcan Saylam Kurtipek

    2015-01-01

    Full Text Available Aim. Many studies demonstrated that alopecia areata (AA and vitiligo are commonly associated with autoimmune thyroid diseases. We aimed to investigate the frequency of thyroid dysfunctions and autoimmunity related with vitiligo and AA. Material and Methods. 200 patients, 92 AA and 108 vitiligo diagnosed, were surveyed retrospectively. The control population was in reference range and from Konya, central Anatolian region of Turkey. Thyroid function tests (free T3, free T4, and TSH and serum thyroid autoantibody (anti-TG, anti-TPO levels were evaluated in all patients. Results. In vitiligo patients, 9 (8.3% had elevated anti-TG levels and 16 (14.8% had elevated anti-TPO, and in 17 patients (15.7% TSH levels were elevated and 3 (2.8% patients had elevated fT4 levels and 5 (4.6% had elevated fT3 levels. Within AA patients, 2 (2.2% had anti-TG elevation and 13 (14.1% had anti-TPO elevation, in 7 patients (7.6% TSH were elevated, and in 1 patient (1.1% fT4 were elevated and 5 (5.4% patients had elevated fT3 levels. Conclusion. In our study, impaired thyroid functions and thyroid autoantibodies in vitiligo and AA patients were identified at lower rates than the previous studies. According to results of this study there is no need for detailed examination in alopecia areata and vitiligo patients without clinical history.

  1. The prostamide-related glaucoma therapy, bimatoprost, offers a novel approach for treating scalp alopecias.

    Science.gov (United States)

    Khidhir, Karzan G; Woodward, David F; Farjo, Nilofer P; Farjo, Bessam K; Tang, Elaine S; Wang, Jenny W; Picksley, Steven M; Randall, Valerie A

    2013-02-01

    Balding causes widespread psychological distress but is poorly controlled. The commonest treatment, minoxidil, was originally an antihypertensive drug that promoted unwanted hair. We hypothesized that another serendipitous discovery, increased eyelash growth side-effects of prostamide F(2α)-related eyedrops for glaucoma, may be relevant for scalp alopecias. Eyelash hairs and follicles are highly specialized and remain unaffected by androgens that inhibit scalp follicles and stimulate many others. Therefore, we investigated whether non-eyelash follicles could respond to bimatoprost, a prostamide F(2α) analog recently licensed for eyelash hypotrichosis. Bimatoprost, at pharmacologically selective concentrations, increased hair synthesis in scalp follicle organ culture and advanced mouse pelage hair regrowth in vivo compared to vehicle alone. A prostamide receptor antagonist blocked isolated follicle growth, confirming a direct, receptor-mediated mechanism within follicles; RT-PCR analysis identified 3 relevant receptor genes in scalp follicles in vivo. Receptors were located in the key follicle regulator, the dermal papilla, by analyzing individual follicular structures and immunohistochemistry. Thus, bimatoprost stimulates human scalp follicles in culture and rodent pelage follicles in vivo, mirroring eyelash behavior, and scalp follicles contain bimatoprost-sensitive prostamide receptors in vivo. This highlights a new follicular signaling system and confirms that bimatoprost offers a novel, low-risk therapeutic approach for scalp alopecias.

  2. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia.

    Science.gov (United States)

    Shamma, Rehab Nabil; Aburahma, Mona Hassan

    2014-01-01

    Spironolactone (SL) is a US Food and Drug Administration-approved drug for the treatment of hypertension and various edematous conditions. SL has gained a lot of attention for treating androgenic alopecia due to its potent antiandrogenic properties. Recently, there has been growing interest for follicular targeting of drug molecules for treatment of hair and scalp disorders using nanocolloidal lipid-based delivery systems to minimize unnecessary systemic side effects associated with oral drug administration. Accordingly, the objective of this study is to improve SL efficiency and safety in treating alopecia through the preparation of colloidal nanostructured lipid carriers (NLCs) for follicular drug delivery. SL-loaded NLCs were prepared by an emulsion solvent diffusion and evaporation method using 23 full factorial design. All of the prepared formulations were spherical in shape with nanometric size range (215.6-834.3 nm) and entrapment efficiency >74%. Differential scanning calorimetry thermograms and X-ray diffractograms revealed that SL exists in amorphous form within the NLC matrices. The drug release behavior from the NLCs displayed an initial burst release phase followed by sustained release of SL. Confocal laser scanning microscopy confirmed the potential of delivering the fluorolabeled NLCs within the follicles, suggesting the possibility of using SL-loaded NLCs for localized delivery of SL into the scalp hair follicles.

  3. Clinical and molecular characterization of two patients with palmoplantar keratoderma-congenital alopecia syndrome type 2.

    Science.gov (United States)

    Castori, M; Morlino, S; Sana, M E; Paradisi, M; Tadini, G; Angioni, A; Malacarne, M; Grammatico, P; Iascone, M; Forzano, F

    2016-08-01

    Palmoplantar keratoderma-congenital alopecia (PPKCA) syndrome is a rare genodermatosis, with two clinically recognizable forms: dominant (Type 1) and recessive (Type 2). Reports of only 18 patients have been published to date, and the molecular basis of the condition is unknown. We describe two cases with PPKCA Type 2 (PPKCA2), comprising a novel patient, originally reported as an example of autosomal ichthyosis follicularis-atrichia-photophobia syndrome, and the 6-year follow-up of a previously published case. Extensive molecular studies of both patients excluded mutations in all the known genes associated with PPK and partially overlapping syndromes. The striking similarities between these two patients confirm PPKCA2 as a discrete genodermatosis, of which the main features are congenital and universal alopecia, diffuse keratosis pilaris, facial erythema, and a specific PPK with predominant involvement of the fingertips and borders of the hands and feet, with evolution of sclerodactyly, contractures and constrictions. Clinical follow-up of these patients has demonstrated progressive worsening of the hand involvement and attenuation of facial erythema.

  4. Chemical peeling with phenol : For the treatment of stable vitiligo and alopecia areata

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    Savant Satish

    1999-01-01

    Full Text Available Chemical peeling with 88% phenol was carried out on 142 sites of stable vitiligo (hairy-126, non hairy-16 and on 69 sites of alopecia areata (AA. After cleansing and defatting, phenol was applied on affected areas till a uniform frost appeared. On healing, all the lesions of vitiligo showed perifollicular pigmentation in hairy areas and perilesional repigmentation in non hairy areas. These were further treated with PUVA/PUVASOL. After the healing, 82.5% of hairy sites and 81.3% of non hairy sites showed repigmentation. In cases of AA, patients developed vellus hair. In AA, 72.5% had good regrowth and 27.5% had poor response. Side effects seen were hypopigmentation (58 AA, hyperpigmentation (11 AA, persistent erythema (42 vitiligo, 28 AA, demarcation lines (4 AA, secondary bacterial infection (2 vitiligo, 5 AA and superficial scarring (2 vitiligo, 7 AA. The wounding action of phenol is useful to repigment the vitiligo patches and for induction of regrwoth of hair in alopecia areata.

  5. Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology

    NARCIS (Netherlands)

    Heilmann, S.; Kiefer, A.K.; Fricker, N.; Drichel, D.; Hillmer, A.M.; Herold, C.; Tung, J.Y.; Eriksson, N.; Redler, S.; Betz, R.C.; Li, R.; Karason, A.; Nyholt, D.R.; Song, K.; Vermeulen, S.; Kanoni, S.; Dedoussis, G.; Martin, N.G.; Kiemeney, L.A.L.M.; Mooser, V.; Stefansson, K.; Richards, J.B.; Becker, T.; Brockschmidt, F.F.; Hinds, D.A.; Nothen, M.M.

    2013-01-01

    The pathogenesis of androgenetic alopecia (AGA, male-pattern baldness) is driven by androgens, and genetic predisposition is the major prerequisite. Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms (SNPs) at eight different genomic loci are associ

  6. Diaminodiphenyl Sulfone-Induced Hemolytic Anemia and Alopecia in a Case of Linear IgA Bullous Dermatosis.

    Science.gov (United States)

    Akasaka, Eijiro; Kayo, Sato-Jin; Nakano, Hajime; Ishii, Norito; Hashimoto, Takashi; Sawamura, Daisuke

    2015-01-01

    Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is an autoimmune mucocutaneous disease characterized by subepidermal blistering induced by IgA autoantibodies against several autoantigens in the basal membranous zone of the skin and mucosal tissue. Although diaminodiphenyl sulfone (DDS), also known as dapsone, is generally recognized as the first-line therapy for LABD, DDS can induce several severe side effects. We present a Japanese case of LABD with DDS-induced hemolytic anemia and alopecia. In the present case, the DDS-induced hemolytic anemia and hair loss made the DDS monotherapy difficult. When DDS is used in LABD patients with iron deficiency anemia (IDA), hemolytic anemia is concealed by IDA. It is thus necessary to carefully and frequently examine the laboratory data to find the signs of DDS-induced hemolytic anemia. Even though there is no literature on DDS-induced alopecia, alopecia was reported as one of the side effects of DDS in an FDA report, and, in our case, hair loss was improved after reducing its dosage. We have to recognize that alopecia is one of the side effects of DDS and that careful management is needed in order not to overlook the adverse side effects of DDS when treating LABD patients.

  7. Diaminodiphenyl Sulfone-Induced Hemolytic Anemia and Alopecia in a Case of Linear IgA Bullous Dermatosis

    Directory of Open Access Journals (Sweden)

    Eijiro Akasaka

    2015-07-01

    Full Text Available Linear immunoglobulin A (IgA bullous dermatosis (LABD is an autoimmune mucocutaneous disease characterized by subepidermal blistering induced by IgA autoantibodies against several autoantigens in the basal membranous zone of the skin and mucosal tissue. Although diaminodiphenyl sulfone (DDS, also known as dapsone, is generally recognized as the first-line therapy for LABD, DDS can induce several severe side effects. We present a Japanese case of LABD with DDS-induced hemolytic anemia and alopecia. In the present case, the DDS-induced hemolytic anemia and hair loss made the DDS monotherapy difficult. When DDS is used in LABD patients with iron deficiency anemia (IDA, hemolytic anemia is concealed by IDA. It is thus necessary to carefully and frequently examine the laboratory data to find the signs of DDS-induced hemolytic anemia. Even though there is no literature on DDS-induced alopecia, alopecia was reported as one of the side effects of DDS in an FDA report, and, in our case, hair loss was improved after reducing its dosage. We have to recognize that alopecia is one of the side effects of DDS and that careful management is needed in order not to overlook the adverse side effects of DDS when treating LABD patients.

  8. Twenty-nail dystrophy (trachyonychia) caused by lichen planus in a patient with alopecia universalis and ichthyosis vulgaris.

    Science.gov (United States)

    Taniguchi, S; Kutsuna, H; Tani, Y; Kawahira, K; Hamada, T

    1995-11-01

    A 7-year-old girl with alopecia universalis had dystrophy of all 20 nails. A nail biopsy specimen disclosed features of lichen planus. The patient also had ichthyosis vulgaris and hypogammaglobulinemia. We are not aware of any previous reports of these associations, which we believe to be noncoincidental.

  9. Prevalence and spatio-temporal variation of an alopecia syndrome in polar bears (Ursus maritimus) of the southern Beaufort Sea

    Science.gov (United States)

    Atwood, Todd C.; Peacock, Elizabeth; Burek, K.A.; Shearn-Bochsler, Valerie I.; Bodenstein, Barbara L.; Beckmen, Kimberlee B.; Durner, George M.

    2015-01-01

    Alopecia (hair loss) has been observed in several marine mammal species and has potential energetic consequences for sustaining a normal core body temperature, especially for Arctic marine mammals routinely exposed to harsh environmental conditions. Polar bears (Ursus maritimus) rely on a thick layer of adipose tissue and a dense pelage to ameliorate convective heat loss while moving between sea ice and open water. From 1998 to 2012, we observed an alopecia syndrome in polar bears from the southern Beaufort Sea of Alaska that presented as bilaterally asymmetrical loss of guard hairs and thinning of the undercoat around the head, neck, and shoulders, which, in severe cases, was accompanied by exudation and crusted skin lesions. Alopecia was observed in 49 (3.45%) of the bears sampled during 1,421 captures, and the apparent prevalence varied by years with peaks occurring in 1999 (16%) and 2012 (28%). The probability that a bear had alopecia was greatest for subadults and for bears captured in the Prudhoe Bay region, and alopecic individuals had a lower body condition score than unaffected individuals. The cause of the syndrome remains unknown and future work should focus on identifying the causative agent and potential effects on population vital rates.

  10. Reticulate Pigmentation Associated with Scarring Alopecia in an Elderly Woman: An Unusual Manifestation of Lichen Planus Pigmentosus

    Science.gov (United States)

    Sharma, Vinod Kumar; Bhari, Neetu; Subhadarshani, Sweta; Taneja, Neha; Deepak, Rakesh Kumar

    2016-01-01

    A 70-year-old woman presented with generalized reticulate pigmentation, scarring alopecia, and few discrete, violaceous plaques over the trunk and forearm. Dermoscopic evaluation of the reticulate plaque showed reticulate hyperpigmentation with multiple telangiectasias, and skin biopsy showed lichenoid interface dermatitis with marked pigment incontinence. Thus, a final diagnosis of poikiloderma due to lichen planus pigmentosus was considered. PMID:27904206

  11. Reticulate pigmentation associated with scarring alopecia in an elderly woman: An unusual manifestation of lichen planus pigmentosus

    Directory of Open Access Journals (Sweden)

    Vinod Kumar Sharma

    2016-01-01

    Full Text Available A 70-year-old woman presented with generalized reticulate pigmentation, scarring alopecia, and few discrete, violaceous plaques over the trunk and forearm. Dermoscopic evaluation of the reticulate plaque showed reticulate hyperpigmentation with multiple telangiectasias, and skin biopsy showed lichenoid interface dermatitis with marked pigment incontinence. Thus, a final diagnosis of poikiloderma due to lichen planus pigmentosus was considered.

  12. Positivity of autologous serum skin test in patients with alopecia areata and vitiligo and in healthy individuals

    Directory of Open Access Journals (Sweden)

    Münevver Güven

    2015-09-01

    Full Text Available Background and Design: Autologous serum skin test (ASST, the best in-vivo test displaying in vitro basophil histamin releasing activity, is used in the diagnosis of chronic autoimmune urticaria. Besides, it is cheap and is easy to perform. It has been found that in ASST-positive chronic urticaria patients, autoimmune thyroid disease especially and other autoimmune diseases were more common and the level of autoimmune markers were higher compared to others. Autoimmunity is accused in the pathogenesis of alopecia areata and vitiligo. In this study, we assessed ASST results in healthy controls and those with autoimmune diseases, and aimed to explore the effects of thyroid autoantibodies and other factors in ASST positivity. Materials and Methods: ASST was administered to 51 patients with alopecia areata, 53 patients with vitiligo and 51 healthy controls, and thyroid function tests and thyroid autoantibodies (anti-Tg, anti-TPO were assessed. Results: ASST was positive in 64.7% of patients with in alopecia areata, 64.2% of those with vitiligo and in 45.1% of controls. There was no statistically significant difference between the groups in terms of ASST positivity. We observed that ASST positivity had no relationship with age, anti-Tg, anti-TPO and the presence of one or both autoantibody positivity. It was seen that the frequency of ASST positivity was higher in females than in men in all groups, but it was statistically significant in alopecia areata group only. Among the all study groups, the frequency of ASST positivity was statistically significantly higher in females than in men. Conclusion: The high rates of ASST positivity in individuals with alopecia areata and vitiligo as well as in healthy control, indicate that ASST positivity does not solely exist in chronic urticaria patients. With logical regression analysis, it was shown that, having alopecia areata and being female significantly increase the risk of having ASST positivity. Therefore

  13. Lipid nanoparticles for topical and transdermal application for alopecia treatment: development, physicochemical characterization, and in vitro release and penetration studies

    Directory of Open Access Journals (Sweden)

    Gomes MJ

    2014-03-01

    Full Text Available Maria João Gomes,1 Susana Martins,2,3 Domingos Ferreira,2 Marcela A Segundo,1 Salette Reis1 1REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, 2Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; 3Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark Abstract: Alopecia is a dermatological disorder, commonly known as hair loss, which affects up to half of the Caucasian male population by middle age, and almost all (95% Caucasian men by old age. Considering that alopecia affects so many people and that there is currently no scientifically proven treatment with few side effects, new drug-delivery systems able to improve alopecia therapy are urgently required. With this purpose in mind, the present study aimed to develop lipid nanoparticles (nanostructured lipid carriers with the ability to incorporate and deliver anti-alopecia active compounds (minoxidil and finasteride into the dermis and hair follicles. Lipid nanoparticles, prepared by ultrasonication method, showed mean particle sizes around 200 nm, which is sufficient for reaching the dermis and hair follicles, and zeta potential values around -30 mV, which indicates good physical stability. Over 28 days of storage, no significant variations in these parameters were observed, which indicates that all nanoformulations are stable in storage over that period. Cryo-scanning electron microscope measurements showed that all the lipid nanoparticles exhibited a spherical shape and a smooth surface regardless of their composition. Differential scanning calorimetry studies allowed the determination of phase transition temperatures and confirmed the recrystallization of the lipid nanoparticles (recrystallization index between 11% and 86%. A high loading efficiency was achieved for finasteride (between 70% and 90%, while less than 30% was

  14. Advance of study on androgenic alopecia (a review)%雄激素源性秃发的研究进展

    Institute of Scientific and Technical Information of China (English)

    宋宁静

    2002-01-01

    @@ 1病名来源雄激素源性脱发(Androgenic Alopecia,简称AGA)是一种雄激素依赖性的遗传性毛发脱落病.过去又称寻常秃发(Common baldness)、早秃(Alopecia Prematura)或脂溢性脱发(Seborrheic Alopecia),以上病名沿用多年,直至1960年才由Orenlreich氏首先命名为AGA,因为本病的发生与遗传性素质和雄性激素有关[1].

  15. Low-level laser treatment accelerated hair regrowth in a rat model of chemotherapy-induced alopecia (CIA).

    Science.gov (United States)

    Wikramanayake, Tongyu Cao; Villasante, Alexandra C; Mauro, Lucia M; Nouri, Keyvan; Schachner, Lawrence A; Perez, Carmen I; Jimenez, Joaquin J

    2013-05-01

    Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects of antineoplastic chemotherapy for which there is no effective interventional approach. A low-level laser (LLL) device, the HairMax LaserComb®, has been cleared by the FDA to treat androgenetic alopecia. Its effects may be extended to other settings; we have demonstrated that LaserComb treatment induced hair regrowth in a mouse model for alopecia areata. In the current study, we tested whether LLL treatment could promote hair regrowth in a rat model for CIA. Chemotherapy agents cyclophosphamide, etoposide, or a combination of cyclophosphamide and doxorubicin were administered in young rats to induce alopecia, with or without LLL treatment. As expected, 7-10 days later, all the rats developed full body alopecia. However, rats receiving laser treatment regrew hair 5 days earlier than rats receiving chemotherapy alone or sham laser treatment (with the laser turned off). The accelerated hair regrowth in laser-treated rats was confirmed by histology. In addition, LLL treatment did not provide local protection to subcutaneously injected Shay chloroleukemic cells. Taken together, our results demonstrated that LLL treatment significantly accelerated hair regrowth after CIA without compromising the efficacy of chemotherapy in our rat model. Our results suggest that LLL should be explored for the treatment of CIA in clinical trials because LLL devices for home use (such as the HairMax LaserComb®) provide a user-friendly and noninvasive approach that could be translated to increased patient compliance and improved efficacy.

  16. Estudio dermatológico y psiquiátrico en pacientes con alopecia areata

    OpenAIRE

    Miranda Sivelo, Alberto

    2015-01-01

    Este estudio se engloba en el campo de la psicodermatología, disciplina que se ocupa de las enfermedades situadas en las áreas de contacto entre la dermatología y la psiquiatría. En esta investigación se pretende caracterizar los aspectos psicológicos de la alopecia areata ( AA ), evaluando su influencia en la génesis y/o evolución de la enfermedad así como las repercusiones psíquicas y su impacto psico-social. Se ha diseñado un protocolo socio-demográfico, dermatológico y psicopatol...

  17. Koebner phenomenon in alopecia areata: rapid appearance after trichogram. Implications for the pathogenesis and therapy.

    Science.gov (United States)

    D'Ovidio, R

    2013-04-01

    Anecdotical experiences indicate that Koebner phenomenon (KP) can also be observed in alopecia areata (AA). The present short report gives an account of what has been observed in some patients with remitting-relapsing AA in multiple patches, in whom the phenomenon was accidentally caused by perilesional Trichogram. The almost immediate appearance of relapses of the disease (1-7 days) and their evolution can be useful to understand the physiopathology of AA and and emphasize the compelling need for a rapid and appropriate diagnosis and treatment in the acute phase of AA, even with the active participation of the patient adequately trained. The method of trichogram should be reserved for cases in which non-invasive methods such as the Pull Test or Trichoscopy are not sufficient to verify the activity of the disease.

  18. Treatment of Alopecia Areata with Plum-blossom Needles plus Moxibustion: A Report of 53 Cases

    Institute of Scientific and Technical Information of China (English)

    ZHANG Qiao-ling; FU Xiao-hong; YING Xiao-jian; LI Li-ping

    2004-01-01

    用梅花针叩刺斑秃区,后用艾条在患处温灸,治疗斑秃患者53例,并以口服薄芝片为对照治疗54例.3个疗程后前者总有效率为96.2%,后者为70.4%,两组疗效差异有统计意义.%Fifty-three patients with alopecia areata were treated by plum-blossom needles tapping and mild moxibustion of the focus and 54 cases taking Bozhi tablets orally were considered as a control group. The total effective rates were 96.2% and 70.4 respectively after 3-course's treatment.

  19. [Pigmentation abnormalities in the course of topical immunotherapy of alopecia areata].

    Science.gov (United States)

    Valsecchi, R; Pansera, B; Rossi, A; Cainelli, T

    1989-01-01

    Pigmentation troubles have been associated in the past years with contact dermatitis and patch-testing. Contact allergy and increase of pigmentation has been associated with Tinopal; on the other hand contact allergy and depigmentation have been associated with many substances such as DNCB, squaric acid dibutylester (SADBE), carbyne, alstroemeria. Leukoderma can also be produced by irritant compound such as phenols, catechols and mercaptoamines. During 1978 and 1984 we have treated 132 patients suffering from alopecia areata with DNCB or SADBE: 51 patients have been treated by DNCB and 81 by SADBE. During the treatment 10 patients developed a leukoderma vitiligo-like localized to the areas of topical application of the allergens and to the flare-up site; one patient had an increase of pigmentation. Lesions vitiligo-like appeared 10-15 weeks after the onset of treatment. Among the patients who developed leukoderma, 4 had a personal history of vitiligo. The possible pathogenetic mechanisms are discussed.

  20. A Scandinavian case of skin fragility, alopecia and cardiomyopathy caused by DSP mutations.

    Science.gov (United States)

    Vahlquist, A; Virtanen, M; Hellström-Pigg, M; Dragomir, A; Ryberg, K; Wilson, N J; Östman--Smith, I; Lu, L; McGrath, J A; Smith, F J D

    2014-01-01

    Congenital skin fragility is a heterogeneous disorder with epidermolysis bullosa and various skin infections as the leading causes. However, even rare diseases must be considered in the differential diagnosis of neonatal skin blistering, including some genetic syndromes with extracutaneous involvement. One such syndrome is ectodermal dysplasia due to deficiency of desmoplakin, a desmosomal protein essential for cellular cohesion in both epithelia and cardiac tissues. Desmoplakin is encoded by the DSP gene, which is localized on chromosome 6p24. Both dominant and recessive mutations in this gene have been reported to cause skin fragility and keratinization defects. We report a child born with a fragile epidermis, alopecia, thick nails, and focal hyperkeratoses on the digits and knees. She was found to have a deficiency of desmoplakin caused by compound heterozygous DSP mutations. She has gradually developed signs of a left ventricular cardiomyopathy.

  1. Halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy.

    Science.gov (United States)

    Nadesalingam, Kavitha; Goodfield, Mark; Emery, Paul

    2016-08-01

    We present a follow-up case report of a 33-year-old lady with juvenile onset arthritis who developed halo naevi while on treatment with tocilizumab. This case report describes the development of halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy following infection with Methicillin-resistant Staphylococcus aureus (MRSA) and Panton-Valentine leukocidin positivity. This is the first case that describes these events and supports previous theories on cellular and humoral immunity as causative factors. The regression of melanocytes during treatment with tocilizumab could also implicate IL-6 and sIL-6R as future targets in the treatment of melanoma through its direct effect of melanocytic cytotoxicity, which supports previous studies.

  2. Psicoterapia de criança com alopecia areata universal: desenvolvendo a resiliência

    Directory of Open Access Journals (Sweden)

    Marina Menezes

    2010-08-01

    Full Text Available Este artigo apresenta um estudo de caso de uma criança portadora de alopecia areata universal, vitiligo e transtorno de ansiedade generalizada, atendida em clínica-escola de psicologia de 2002 a 2007. A abordagem terapêutica adotada foi a psicoterapia de orientação psicanalítica infantil e a orientação sistemática aos pais, objetivando a diminuição dos sintomas e o desenvolvimento de habilidades para o enfrentamento da doença crônica. No decorrer do processo, ao longo dos cinco anos de atendimento, a paciente adaptou-se positivamente à doença, ocorrendo a remissão dos sintomas de ansiedade e o desenvolvimento de comportamentos resilientes que indicaram a alta terapêutica.

  3. Meibomian gland dysfunction in a case of ichthyosis follicularis with alopecia and photophobia syndrome

    Directory of Open Access Journals (Sweden)

    Tarannum Fatima

    2014-01-01

    Full Text Available We are reporting an interesting case of ichthyosis follicularis with alopecia and photophobia syndrome in a daughter and father from the Indian subcontinent associated with Meibomian gland dysfunction. A three-year-old female child presented with pain, redness and severe photophobia in both eyes since one month. Cutaneous examination revealed ichthyosis, absence of hair all over the body including eyebrows, scalp and angular cheilosis. Ocular examination revealed bilateral severe meibomianitis, multiple superficial punctate keratitides in right eye and corneal epithelial defect in the left eye. Other systemic features were prominent high forehead and large ears. Her father had similar symptoms. Her symptoms improved after adequate treatment of meibomian gland dysfunction. She is asymptomatic at present.

  4. Identification and Treatment of Psychotropic Drug-induced Alopecia%精神药物致脱发的识别与处理

    Institute of Scientific and Technical Information of China (English)

    孙振晓; 于相芬

    2014-01-01

    多种精神药物可引起脱发,本文对脱发的概念、精神药物所致脱发的诊断、鉴别诊断、发病机制及处理等作一综述,以提高临床对精神药物所致脱发的认识。%A variety of psychotropic drugs can cause alopecia . In order to make a better understanding of psy-chotropic drug-induced alopecia , this article made a review on the definition of alopecia , diagnosis , differential diag-nosis , pathomechanism and the treatment of psychotropic drug-induced alopecia .

  5. Enhanced biological processes associated with alopecia in polar bears (Ursus maritimus)

    Science.gov (United States)

    Bowen, Lizabeth; Miles, A. Keith; Stott, Jeffrey L.; Waters, Shannon C.; Atwood, Todd C.

    2015-01-01

    Populations of wildlife species worldwide experience incidents of mass morbidity and mortality. Primary or secondary drivers of these events may escape classical detection methods for identifying microbial insults, toxin exposure, or additional stressors. In 2012, 28% of polar bears sampled in a study in the southern Beaufort Sea region of Alaska had varying degrees of alopecia that was concomitant with reduced body condition. Concurrently, elevated numbers of sick or dead ringed seals were detected in the southern Beaufort, Chukchi, and Bering seas in 2012, resulting in the declaration of an unusual mortality event (UME) by the National Oceanic and Atmospheric Administration (NOAA). The primary and possible ancillary causative stressors of these events are unknown, and related physiological changes within individual animals have been undetectable using classical diagnostic methods. Here we present an emerging technology as a potentially guiding investigative approach aimed at elucidating the circumstances responsible for the susceptibility of certain polar bears to observed conditions. Using transcriptomic analysis we identified enhanced biological processes including immune response, viral defense, and response to stress in polar bears with alopecia. Our results support an alternative mechanism of investigation into the causative agents that, when used proactively, could serve as an early indicator for populations and species at risk. We suggest that current or classical methods for investigation into events of unusual morbidity and mortality can be costly, sometimes unfocused, and often inconclusive. Advances in technology allow for implementation of a holistic system of surveillance and investigation that could provide early warning of health concerns in wildlife species important to humans.

  6. Evaluation of DNA variants associated with androgenetic alopecia and their potential to predict male pattern baldness.

    Science.gov (United States)

    Marcińska, Magdalena; Pośpiech, Ewelina; Abidi, Sarah; Andersen, Jeppe Dyrberg; van den Berge, Margreet; Carracedo, Ángel; Eduardoff, Mayra; Marczakiewicz-Lustig, Anna; Morling, Niels; Sijen, Titia; Skowron, Małgorzata; Söchtig, Jens; Syndercombe-Court, Denise; Weiler, Natalie; Schneider, Peter M; Ballard, David; Børsting, Claus; Parson, Walther; Phillips, Chris; Branicki, Wojciech

    2015-01-01

    Androgenetic alopecia, known in men as male pattern baldness (MPB), is a very conspicuous condition that is particularly frequent among European men and thus contributes markedly to variation in physical appearance traits amongst Europeans. Recent studies have revealed multiple genes and polymorphisms to be associated with susceptibility to MPB. In this study, 50 candidate SNPs for androgenetic alopecia were analyzed in order to verify their potential to predict MPB. Significant associations were confirmed for 29 SNPs from chromosomes X, 1, 5, 7, 18 and 20. A simple 5-SNP prediction model and an extended 20-SNP model were developed based on a discovery panel of 305 males from various European populations fitting one of two distinct phenotype categories. The first category consisted of men below 50 years of age with significant baldness and the second; men aged 50 years or older lacking baldness. The simple model comprised the five best predictors: rs5919324 near AR, rs1998076 in the 20p11 region, rs929626 in EBF1, rs12565727 in TARDBP and rs756853 in HDAC9. The extended prediction model added 15 SNPs from five genomic regions that improved overall prevalence-adjusted predictive accuracy measured by area under the receiver characteristic operating curve (AUC). Both models were evaluated for predictive accuracy using a test set of 300 males reflecting the general European population. Applying a 65% probability threshold, high prediction sensitivity of 87.1% but low specificity of 42.4% was obtained in men aged <50 years. In men aged ≥50, prediction sensitivity was slightly lower at 67.7% while specificity reached 90%. Overall, the AUC=0.761 calculated for men at or above 50 years of age indicates these SNPs offer considerable potential for the application of genetic tests to predict MPB patterns, adding a highly informative predictive system to the emerging field of forensic analysis of externally visible characteristics.

  7. Evaluation of DNA variants associated with androgenetic alopecia and their potential to predict male pattern baldness.

    Directory of Open Access Journals (Sweden)

    Magdalena Marcińska

    Full Text Available Androgenetic alopecia, known in men as male pattern baldness (MPB, is a very conspicuous condition that is particularly frequent among European men and thus contributes markedly to variation in physical appearance traits amongst Europeans. Recent studies have revealed multiple genes and polymorphisms to be associated with susceptibility to MPB. In this study, 50 candidate SNPs for androgenetic alopecia were analyzed in order to verify their potential to predict MPB. Significant associations were confirmed for 29 SNPs from chromosomes X, 1, 5, 7, 18 and 20. A simple 5-SNP prediction model and an extended 20-SNP model were developed based on a discovery panel of 305 males from various European populations fitting one of two distinct phenotype categories. The first category consisted of men below 50 years of age with significant baldness and the second; men aged 50 years or older lacking baldness. The simple model comprised the five best predictors: rs5919324 near AR, rs1998076 in the 20p11 region, rs929626 in EBF1, rs12565727 in TARDBP and rs756853 in HDAC9. The extended prediction model added 15 SNPs from five genomic regions that improved overall prevalence-adjusted predictive accuracy measured by area under the receiver characteristic operating curve (AUC. Both models were evaluated for predictive accuracy using a test set of 300 males reflecting the general European population. Applying a 65% probability threshold, high prediction sensitivity of 87.1% but low specificity of 42.4% was obtained in men aged <50 years. In men aged ≥50, prediction sensitivity was slightly lower at 67.7% while specificity reached 90%. Overall, the AUC=0.761 calculated for men at or above 50 years of age indicates these SNPs offer considerable potential for the application of genetic tests to predict MPB patterns, adding a highly informative predictive system to the emerging field of forensic analysis of externally visible characteristics.

  8. Assessing significant (>30%) alopecia as a possible biomarker for stress in captive rhesus monkeys (Macaca mulatta).

    Science.gov (United States)

    Novak, Melinda A; Menard, Mark T; El-Mallah, Saif N; Rosenberg, Kendra; Lutz, Corrine K; Worlein, Julie; Coleman, Kris; Meyer, Jerrold S

    2017-01-01

    Hair loss is common in macaque colonies. Very little is known about the relationship between psychological stress and hair loss. We initially examined alopecia and hair cortisol concentrations in 198 (89 male) rhesus macaques from three primate centers and demonstrated replicability of our previous finding that extensive alopecia (>30% hair loss) is associated with increased chronic cortisol concentrations and significantly affected by facility. A subset of these monkeys (142 of which 67 were males) were sampled twice approximately 8 months apart allowing us to examine the hypotheses that gaining hair should be associated with decreases in cortisol concentrations and vice versa. Hair loss was digitally scored using ImageJ software for the first sample. Then visual assessment was used to examine the second sample, resulting in three categories of coat condition: (i) monkeys that remained fully haired; (ii) monkeys that remained alopecic (with more than 30% hair loss); or (iii) monkeys that showed more than a 15% increase in hair. The sample size for the group that lost hair was too small to be analyzed. Consistent with our hypothesis, monkeys that gained hair showed a significant reduction in hair cortisol concentrations but this effect only held for females. Coat condition changed little across sampling periods with only 25 (11 male) monkeys showing a greater than 15% gain of hair. Twenty (7 male) monkeys remained alopecic, whereas 97 (49 males) remained fully haired. Hair cortisol was highly correlated across samples for the monkeys that retained their status (remained alopecic or retained their hair). Am. J. Primatol. 79:e22547, 2017. © 2016 Wiley Periodicals, Inc.

  9. Enhanced biological processes associated with alopecia in polar bears (Ursus maritimus).

    Science.gov (United States)

    Bowen, Lizabeth; Miles, A Keith; Stott, Jeffrey; Waters, Shannon; Atwood, Todd

    2015-10-01

    Populations of wildlife species worldwide experience incidents of mass morbidity and mortality. Primary or secondary drivers of these events may escape classical detection methods for identifying microbial insults, toxin exposure, or additional stressors. In 2012, 28% of polar bears sampled in a study in the southern Beaufort Sea region of Alaska had varying degrees of alopecia that was concomitant with reduced body condition. Concurrently, elevated numbers of sick or dead ringed seals were detected in the southern Beaufort, Chukchi, and Bering seas in 2012, resulting in the declaration of an unusual mortality event (UME) by the National Oceanic and Atmospheric Administration (NOAA). The primary and possible ancillary causative stressors of these events are unknown, and related physiological changes within individual animals have been undetectable using classical diagnostic methods. Here we present an emerging technology as a potentially guiding investigative approach aimed at elucidating the circumstances responsible for the susceptibility of certain polar bears to observed conditions. Using transcriptomic analysis we identified enhanced biological processes including immune response, viral defense, and response to stress in polar bears with alopecia. Our results support an alternative mechanism of investigation into the causative agents that, when used proactively, could serve as an early indicator for populations and species at risk. We suggest that current or classical methods for investigation into events of unusual morbidity and mortality can be costly, sometimes unfocused, and often inconclusive. Advances in technology allow for implementation of a holistic system of surveillance and investigation that could provide early warning of health concerns in wildlife species important to humans.

  10. 'My wig has been my journey's companion': perceived effects of an aesthetic care programme for Italian women suffering from chemotherapy-induced alopecia.

    Science.gov (United States)

    Zannini, L; Verderame, F; Cucchiara, G; Zinna, B; Alba, A; Ferrara, M

    2012-09-01

    This study explored the perceived effects of an aesthetic care/wig programme for Italian women suffering from chemotherapy-induced alopecia. Despite advances in the treatment of many side effects of chemotherapy, alopecia remains difficult to resolve. Literature suggests that patients' reactions to alopecia and camouflaging strategies depend on their gender, individual characteristics, social context, and culture. A qualitative study was designed involving 20 patients from Sicily (Italy), who participated in an aesthetic care programme. Data were collected through semi-structured interviews, and an Interpretative Phenomenological Analysis was conducted on transcriptions. Our findings showed that, even if expected, alopecia is experienced as a traumatic event that challenges a woman's femininity, as reported by many other enquiries. Diverging from other studies, the wig is perceived as very helpful, since it camouflages baldness and reduces the 'sick aspect' related to alopecia. Patients consider their wig to be a 'friend', and it appears that through the aesthetic care programme they received support they otherwise would not have sought. We conclude that aesthetic care/wig programmes can help women affected by alopecia to cope with cancer 'stigma', especially in those rural contexts where psychosocial programmes are not frequently embraced by patients due to environmental and cultural barriers.

  11. Apoptose, microinflamação e expressão de receptores de hidrocarboneto arílico nos folículos pilosos de pacientes com alopecia de padrão feminino

    OpenAIRE

    2013-01-01

    Female pattern alopecia, or female androgenetic alopecia, is the main cause of hair loss in adult women and causes major impact on patient´s quality of life. It evolves from the progressive miniaturization of follicles that lead to a subsequent decrease of the hair density, leading to a non-scarring diffuse alopecia, with characteristic clinical, dermoscopic and histological pattern. Despite the high frequency and relevance about the psychological impact, its pathogenesis is not yet fully und...

  12. Attitudes of dermatologists in the southeastern United States regarding treatment of alopecia areata: a cross-sectional survey study

    Directory of Open Access Journals (Sweden)

    Stewart Paul W

    2009-11-01

    Full Text Available Abstract Background Little evidence exists to guide treatment of alopecia areata (AA. The current practices in treatment of children compared to adults and of progressive stages of hair loss are unknown. The objective of this study was to examine the current practices of southeastern United States dermatologists for the treatment of AA. Methods Dermatologists were sent anonymous questionnaires regarding their treatment practices by mail. Respondents' frequencies of treatment in children compared to adults and in patchy hair loss compared to widespread hair loss were compared with Wilcoxon signed-ranks tests and Friedman tests. As a secondary source, the National Alopecia Areata Registry (NAAR database was analyzed for patients' treatment histories. Results Survey results suggested that dermatologists recommend treatment less frequently for children than adults and for more advanced hair loss. NAAR data confirmed that offering no treatment for AA is relatively common. Conclusion Dermatologists' treatment of AA is inconsistent. A stronger evidence base will provide more consistent treatment options.

  13. Anti-inflammatory and immunomodulating properties of the herbal preparation indicated for prevention and treatment of alopecia

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    Galkin AY

    2013-10-01

    Full Text Available Alexander Yu Galkin,1,2 Valentine F Solovjova,3 Alex M Dugan11Department of Industrial Biotechnology, Faculty of Biotechnology and Bioengineering, National Technical University of Ukraine "Kyiv Polytechnic Institute", Kyiv, Ukraine; 2Research and Development Department, PRO-PHARMA Company, LLC, Kyiv, Ukraine; 3Laboratory of Hygiene Expertise, Ukrainian Research Institute of Nutrition, Biotechnology and Pharmacy, Kyiv, UkraineBackground: Alopecia is a chronic inflammatory disease, in which the hair follicles become damaged. The etiology of the disease is still little known; the most common cause of alopecia is likely an autoimmune mechanism. Medicinal herbs (Arctium lappa roots, Sophora japonica fruits, Acorus calamus roots, Urtica dioica leaves, Humulus lupulus fruits are promising remedies for the prevention and treatment of alopecia.Methods: Anti-inflammatory properties of the phytopreparation were investigated using the following models: "rigid" inflammatory model and model of adrenalin pulmonary edema (anti-exudative activity, as well as the "cotton granuloma" model (influence on proliferative effects. Immunomodulatory properties were studied by analyzing the metabolic activity of macrophages exposed to herbal preparation as well as the secretion of monocyte-derived cytokines.Results: Intragastric administration of the herbal preparation reduced severity of the exudation phase of inflammation in the limbs of animals (37.3% and inhibited pulmonary edema (21.0%. It was demonstrated that the phytopreparation reduced the weight of the granulation-fibrous tissue by 50.6%. The phytopreparation activated macrophages (50–400 µg/mL, decreased the number of flattened cells, increased the number of rounded cells and increased the production of oxidative metabolites (by 26% compared with intact cells. The herbal drug (0–300 µg/mL increased cytokines secretion by human blood cells (interleukin-2 and interferon-γ.Conclusion: The phytopreparation

  14. A collection of rare anomalies: multiple digital glomuvenous malformations, epidermal naevus, temporal alopecia, heterochromia and abdominal lipoblastoma.

    Science.gov (United States)

    Hill, S; Rademaker, M

    2009-12-01

    Glomuvenous malformations are a subtype of venous malformations, which present in infancy or childhood. We describe a teenage girl who presented with multiple digital glomuvenous malformations from birth. In addition, she had an epidermal naevus on the upper lip, an area of congenital alopecia of the scalp, heterochromia irides and an abdominal lipoblastoma. We are unaware of any reports of the association of multiple glomuvenous malformations with the other uncommon developmental anomalies seen in our patient, and a common link eludes us.

  15. Alopecia universalis, hypothyroidism and pituitary hyperplasia: polyglandular autoimmune syndrome III in a patient in remission from treated Hodgkin lymphoma.

    LENUS (Irish Health Repository)

    Quintyne, K I

    2010-10-01

    We herein report a case of a 33-year-old man in remission from Hodgkin lymphoma, who presented with reduced potency and hair loss. Initial endocrine tests revealed autoimmune hypothyroidism. An MRI of his pituitary gland at onset revealed hyperplasia. He tolerated replacement endocrine therapy with good response, but with no improvement in his alopecia universalis. A repeat MRI, 6 months after his initial endocrine manipulation, showed resolution of his pituitary hyperplasia.

  16. Uso da fluoxetina no tratamento da tricotilomania felina Use of fluoxetine in the treatment of feline psycogenic alopecia

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    Marlos Gonçalves Sousa

    2004-06-01

    Full Text Available A tricotilomania ou alopecia psicogênica felina é uma dermatopatia de origem psicogênica, decorrente da lambedura compulsiva do pelame, realizada pelo gato em situações de estresse. Tal distúrbio decorre de alterações neuro-hormonais e pode associar-se à introdução de novos animais e/ou crianças no ambiente. Além de mudanças de manejo e atitude para com o animal, sugere-se o emprego de ansiolíticos no tratamento da doença. A fluoxetina foi utilizada no tratamento de cinco gatos domésticos com tricotilomania, apresentando inibição do comportamento de lambedura, com repilação após dois a três meses de terapia.Feline psycogenic alopecia occurs when cats lick their hair compulsively. Stress situations play a role in this disturbance, due to changes in neurohormone mechanisms. The introduction of a new animal or baby in the household can also be associated. Besides behavioral changes towards the animal, the use of anxiolytics is suggested to treat the disease. Fluoxetine was used in the treatment of 5 domestic cats with psycogenic alopecia, showing showing inhibition of licking attitude, with repilation within two to three months of use.

  17. Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability.

    Science.gov (United States)

    Ansar, Muhammad; Jan, Abid; Santos-Cortez, Regie Lyn P; Wang, Xin; Suliman, Muhammad; Acharya, Anushree; Habib, Rabia; Abbe, Izoduwa; Ali, Ghazanfar; Lee, Kwanghyuk; Smith, Joshua D; Nickerson, Deborah A; Shendure, Jay; Bamshad, Michael J; Ahmad, Wasim; Leal, Suzanne M

    2016-08-01

    Alopecia with mental retardation (APMR) is a very rare disorder. In this study, we report on a consanguineous Pakistani family (AP91) with mild-to-moderate intellectual disability, adolescent alopecia and dentogingival abnormalities. Using homozygosity mapping, linkage analysis and exome sequencing, we identified a novel rare missense variant c.898G>A (p.(Glu300Lys)) in ITGB6, which co-segregates with the phenotype within the family and is predicted to be deleterious. Structural modeling shows that Glu300 lies in the β-propeller domain, and is surrounded by several residues that are important for heterodimerization with α integrin. Previous studies showed that ITGB6 variants can cause amelogenesis imperfecta in humans, but patients from family AP91 who are homozygous for the c.898G>A variant present with neurological and dermatological features, indicating a role for ITGB6 beyond enamel formation. Our study demonstrates that a rare deleterious variant within ITGB6 causes not only dentogingival anomalies but also intellectual disability and alopecia.

  18. A CLINICO - INVESTIGATIVE STUDY OF ALOPECIA AREATA WITH SPECIAL REFERENCE TO ITS ASSOCIATION WITH VARIOUS SYSTEMIC AND DERMATOLOGICAL DISORDERS.

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    Gopal

    2013-11-01

    Full Text Available ABSTRACT: BACKGROUND: Alopecia areata is believed to be an autoimmune condition with a worldwide occurrence. It usually presents as patchy, non - scarring hair loss. There is a paucity of clinical data in Asians. OBJECTIVES: To descri be the demographic profile, clinical profile and histopathology of alopecia areata d out the association with various systemic and dermatological disorders. METHODS: 120 cases were included for the study, over a period of 18 months from January 2007 to Jun e 2008. A descriptive study with purposive sampling was done. Demographic data and a detailed history of the patient to rule out associated systemic and dermatological disorders and various autoimmune disorders were documented. RESULTS: 45 (37.5% out of 1 20 cases were in the age group of 21 - 30 years. Male:Female ratio was 2:1. 103 (85.8% patients were Hindus from urban background who were skilled workers. Parietal area was the commonest area involved over scalp, in 38 (31.67% patients. All these data are statistically significant. 7 (5.8% patients had seborrhoeic dermatitis of scalp, 2 (1.6% patients had lichen planus and Vitiligo. 1 (0.8% patient had psoriasis. Family history of alopecia areata was noted in 8 (6.7% patients. Pitting was noted in 14 ( 11.7% patients. 41 (93.2% patients in urban background had emotional stress

  19. A alopecia androgenética na consulta de tricologia do Hospital Geral de Santo António (cidade do Porto, Portugal entre 2004 e 2006: estudo descritivo com componente analítico Androgenetic alopecia in trichology consultation at the Hospital Geral de Santo António (Oporto - Portugal, 2004-2006: a descriptive study with an analytic component

    Directory of Open Access Journals (Sweden)

    Inês Lobo

    2008-06-01

    Full Text Available FUNDAMENTOS: A alopecia androgenética é a causa mais comum de perda progressiva de cabelo. Geralmente ocorre em doentes com predisposição hereditária para esse tipo de alopecia e com androgénios circulantes. OBJETIVO: Avaliar aspectos epidemiológicos e clínicos de pacientes com alopecia androgenética pertencentes ao sexo feminino. MÉTODOS: Realizou-se estudo clínico transversal e descritivo em grupo de mulheres com alopecia androgenética observadas na consulta de tricologia entre 2004 e 2006. Os dados foram analisados com base na estatística descritiva e no teste do qui-quadrado. RESULTADOS: Foram estudadas 200 mulheres com diagnóstico clínico de alopecia androgenética. Em 68% das pacientes foi detectada história familiar e, na maioria das mulheres, a alopecia era frontobiparietal. De acordo com os dados analíticos estudados, 17% delas tiveram níveis baixos de zinco e 9% de albumina e ferritina. Em 20% foi detectada alteração no estudo hormonal. CONCLUSÃO: A alteração analítica mais detectada nas mulheres estudadas com alopecia androgenética foi a alteração hormonal.BACKGROUND: Androgenetic alopecia is the most frequent cause of progressive hair loss. It usually affects individuals with genetic predisposition and sufficient circulating androgens. OBJECTIVE: To assess the clinical and epidemiology aspects of androgenetic alopecia in females. METHODS: A cross-sectional and descriptive study was performed. The sample comprised a group of women with androgenetic alopecia seen in trichology consultation from 2004 to 2006. The results were analyzed using descriptive statistics and the chi-square test. RESULTS: A total of 200 women with clinical diagnosis of androgenetic alopecia were studied. Family history was detected in 68% of patients, and the most common site was frontoparietal hairline. The laboratory tests showed that 17% of females had low zinc and 9% low albumin and ferritin levels. Twenty percent of patients

  20. Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia

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    Claudine Piérard-Franchimont

    2013-01-01

    Full Text Available Skin ageing and gender influences on the scalp have been seldom studied. We revisited the changes in the interfollicular scalp. The study was performed on a population of 650 volunteers (300 women and 350 men for over 7 years. Three age groups were selected in both genders, namely, subjects aged 20–35, 50–60, and 60–70 years. The hair status was further considered according to nonalopecic and alopecic patterns and severity (discrete, moderate, and severe. Biopsies from the parietal area were processed for immunohistochemistry. Stromal cells were distinguished according to the presence of vimentin, Factor XIIIa, CD117, and versican. Blood and lymphatic vessels were highlighted by Ulex europaeus agglutinin-1 and human podoplanin immunoreactivities, respectively. Actinic elastosis was identified by the lysozyme coating of elastic fibres. The epidermis was explored using the CD44 variant 3 and Ki67 immunolabellings. Biplot analyses were performed. Immunohistochemistry revealed a prominent gender effect in young adults. Both Factor XIIIa+ dermal dendrocytes and the microvasculature size decreased with scalp ageing. Alopecia changes mimicked stress-induced premature senescence.

  1. Experiences and coping behaviours of adolescents in Pakistan with alopecia areata: An interpretative phenomenological analysis

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    Rafia Rafique

    2015-01-01

    Full Text Available The study explored experiences of adolescents aged 15–19 with alopecia areata (AA and investigated their accounts of coping behaviours. Interpretative Phenomenological Analysis was used to provide an in-depth and holistic perspective of their accounts. Semi-structured interviews were undertaken with a volunteer sample of eight respondents diagnosed with AA. Four key themes were identified: loss (self/social, concerns (physical/future, negative (emotions/thoughts, and coping styles (adaptive/maladaptive. Females experienced greater feelings of loss, were more concerned about their looks and their future, and reported more negative thoughts and emotions. Females felt angry and blamed God for their fate; males blamed both their fate and luck. Action-oriented and practical coping styles were adopted by all of them. After the realization that initial coping behaviours were ineffective, self-distraction, acceptance, and humour were used. Psychological relief followed with the practice of religion and planning for treatments to be undertaken in the future. The findings here are similar to research conducted in the West, though with more emphasis on religion. Health care providers and student counsellors need to understand the negative psychosocial consequences for adolescents living with a visible disfigurement and provide appropriate psychological and social support.

  2. Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo.

    Science.gov (United States)

    Motofei, Ion G; Rowland, David L; Georgescu, Simona R; Tampa, Mircea; Paunica, Stana; Constantin, Vlad D; Balalau, Cristian; Manea, Mirela; Baleanu, Bogdan C; Sinescu, Ioanel

    2017-01-01

    Finasteride has proved to be relatively safe and effective in the therapeutic management of male androgenic alopecia. However, literature data report several endocrine imbalances inducing various adverse effects, which often persist after treatment cessation in the form of post-finasteride syndrome. Here we present the case of a 52-year-old man receiving finasteride (1 mg/day) who developed an uncommon adverse effect represented by generalized vitiligo 2 months after finasteride discontinuation. Associated adverse effects encountered were represented by mild sexual dysfunction (as determined by the International Index of Erectile Function, IIEF) and moderate depressive symptoms (according to DSM-V criteria), all of these manifestations aggregating within/as a possible post-finasteride syndrome. Further studies should develop and compare several therapeutic approaches, taking into account not only compounds that decrease the circulating dihydrotestosterone level but also those that could block the dihydrotestosterone receptors (if possible, compounds with selective tropism towards the skin). In addition, the possibility of predicting adverse effects of finasteride (according to hand preference and sexual orientation) should be taken into account.

  3. Hyperactivity and alopecia associated with ingestion of valproic acid in a cat.

    Science.gov (United States)

    Zoran, D L; Boeckh, A; Boothe, D M

    2001-05-15

    A 1-year-old castrated male cat was evaluated because of alopecia of approximately 4 to 5 months' duration as well as hyperactive behavior. It was later determined that the cat was ingesting valproic acid by eating food to which it had been added for daily administration to a child in the household who had cerebral palsy. The clinical signs slowly resolved after the source of valproic acid was removed. This emphasizes the sensitivity of cats to drugs that are commonly used in humans. It was not determined whether the clinical signs that developed in this cat were caused by an adverse reaction or from toxicosis as a result of prolonged hepatic elimination of valproic acid, which requires glucuronide metabolism for disposition. However, the cat recovered completely following removal of the drug and prevention of further exposure. This report emphasizes the importance of obtaining a careful and complete history from the owner regarding an animal and its environment. In the cat of this report, the owner had not considered the impact of the presence of the drug in the child's food.

  4. Experiences and coping behaviours of adolescents in Pakistan with alopecia areata: an interpretative phenomenological analysis.

    Science.gov (United States)

    Rafique, Rafia; Hunt, Nigel

    2015-01-01

    The study explored experiences of adolescents aged 15-19 with alopecia areata (AA) and investigated their accounts of coping behaviours. Interpretative Phenomenological Analysis was used to provide an in-depth and holistic perspective of their accounts. Semi-structured interviews were undertaken with a volunteer sample of eight respondents diagnosed with AA. Four key themes were identified: loss (self/social), concerns (physical/future), negative (emotions/thoughts), and coping styles (adaptive/maladaptive). Females experienced greater feelings of loss, were more concerned about their looks and their future, and reported more negative thoughts and emotions. Females felt angry and blamed God for their fate; males blamed both their fate and luck. Action-oriented and practical coping styles were adopted by all of them. After the realization that initial coping behaviours were ineffective, self-distraction, acceptance, and humour were used. Psychological relief followed with the practice of religion and planning for treatments to be undertaken in the future. The findings here are similar to research conducted in the West, though with more emphasis on religion. Health care providers and student counsellors need to understand the negative psychosocial consequences for adolescents living with a visible disfigurement and provide appropriate psychological and social support.

  5. Androgenetic alopecia as an indicator of metabolic syndrome and cardiovascular risk.

    Science.gov (United States)

    Ertas, Ragip; Orscelik, Ozcan; Kartal, Demet; Dogan, Ali; Ertas, Sule Ketenci; Aydogdu, Ebru Guler; Ascioglu, Ozcan; Borlu, Murat

    2016-06-01

    Numerous studies have investigated a probable association between androgenetic alopecia (AGA) and cardiovascular disease (CVD) by researching limited and dispersed parameters. We aimed to evaluate both traditional and non-traditional cardiovascular risk factors in male patients with early-onset AGA. This case-control study included 68 participants: 51 male patients with early-onset AGA and 17 healthy male controls. Patients with AGA were classified into three groups according to the Hamilton-Norwood scale and the presence of vertex hair loss. Traditional and non-traditional cardiovascular risk factors were examined in all study subjects. Metabolic syndrome was diagnosed in 25 patients with AGA and in two control subjects (p baldness and controls (p < 0.05). The pulse-wave velocity values were also found to be significantly higher in patients (p < 0.001). A limitation of this study was the small study population. In conclusion, vertex pattern AGA appears to be a marker for early atherosclerosis. This finding supports the hypothesis that early-onset AGA alone could be an independent risk factor for CVD and metabolic syndrome.

  6. Mutations in the Endothelin Receptor Type A Cause Mandibulofacial Dysostosis with Alopecia

    Science.gov (United States)

    Gordon, Christopher T.; Weaver, K. Nicole; Zechi-Ceide, Roseli Maria; Madsen, Erik C.; Tavares, Andre L.P.; Oufadem, Myriam; Kurihara, Yukiko; Adameyko, Igor; Picard, Arnaud; Breton, Sylvain; Pierrot, Sébastien; Biosse-Duplan, Martin; Voisin, Norine; Masson, Cécile; Bole-Feysot, Christine; Nitschké, Patrick; Delrue, Marie-Ange; Lacombe, Didier; Guion-Almeida, Maria Leine; Moura, Priscila Padilha; Garib, Daniela Gamba; Munnich, Arnold; Ernfors, Patrik; Hufnagel, Robert B.; Hopkin, Robert J.; Kurihara, Hiroki; Saal, Howard M.; Weaver, David D.; Katsanis, Nicholas; Lyonnet, Stanislas; Golzio, Christelle; Clouthier, David E.; Amiel, Jeanne

    2015-01-01

    The endothelin receptor type A (EDNRA) signaling pathway is essential for the establishment of mandibular identity during development of the first pharyngeal arch. We report four unrelated individuals with the syndrome mandibulofacial dysostosis with alopecia (MFDA) who have de novo missense variants in EDNRA. Three of the four individuals have the same substitution, p.Tyr129Phe. Tyr129 is known to determine the selective affinity of EDNRA for endothelin 1 (EDN1), its major physiological ligand, and the p.Tyr129Phe variant increases the affinity of the receptor for EDN3, its non-preferred ligand, by two orders of magnitude. The fourth individual has a somatic mosaic substitution, p.Glu303Lys, and was previously described as having Johnson-McMillin syndrome. The zygomatic arch of individuals with MFDA resembles that of mice in which EDNRA is ectopically activated in the maxillary prominence, resulting in a maxillary to mandibular transformation, suggesting that the p.Tyr129Phe variant causes an EDNRA gain of function in the developing upper jaw. Our in vitro and in vivo assays suggested complex, context-dependent effects of the EDNRA variants on downstream signaling. Our findings highlight the importance of finely tuned regulation of EDNRA signaling during human craniofacial development and suggest that modification of endothelin receptor-ligand specificity was a key step in the evolution of vertebrate jaws. PMID:25772936

  7. Association analysis of the HLA-C gene in Japanese alopecia areata.

    Science.gov (United States)

    Haida, Yuko; Ikeda, Shigaku; Takagi, Atsushi; Komiyama, Etsuko; Mabuchi, Tomotaka; Ozawa, Akira; Kulski, Jerzy K; Inoko, Hidetoshi; Oka, Akira

    2013-07-01

    Alopecia areata (AA) is an organ-specific and cell-mediated autoimmune disease involving hair loss, but its pathogenesis remains poorly understood. Many autoimmune diseases are genetically associated with alleles of the human leukocyte antigen (HLA) genes within the major histocompatibility complex. Associations between AA and HLA genes were previously observed in some different ethnic groups. However, the results were inconsistent, and a primary susceptibility HLA gene and/or region has not yet been assigned for AA. The aim of this study was to evaluate whether an allele of the HLA-C locus, HLA-C*07:04, which was strongly associated with AA in Chinese Hans, could be replicated in the Japanese population. The HLA-C locus was genotyped by the SSO method using 156 AA patients and 560 healthy controls. As a consequence, among the 17 alleles detected, only two alleles, C*04:01 (OR = 2.25, CI 95 % = 1.35-3.75, P = 1.84E-03) and C*15:02 (OR = 2.52, CI 95 % = 1.37-4.64, P = 2.90E-03), were significantly associated with AA after Bonferroni correction. Further, the stratification analysis suggested that C*04:01, C*07:02, and C*15:02 represented different AA genetic risk factors in each sub-phenotype.

  8. Role of platelet-rich plasma in chronic alopecia areata: Our centre experience

    Directory of Open Access Journals (Sweden)

    Sukhbir Singh

    2015-01-01

    Full Text Available Aim: The aim of the study was to evaluate the efficacy of platelet-rich plasma (PRP in the treatment of chronic alopecia areata (AA. Material and Methods: This is a prospective study that was conducted at Kamal Hospital, Kaushambi in which 20 patients who attended the outpatient department were enrolled for the study. All the patients had h/o patches and taken various line of treatments for a duration of 2 years. All the patients were biopsy-proven positive for AA disease. There was no randomisation done since all of them were healthy young adults. The patients′age ranged from 25 to 35 years, and none of them had any co-morbidities. Results: Of 20 patients, only one patient had a relapse. None of the patients had any side effects, and all of them tolerated the procedure well. Conclusion: We wish to conclude that PRP has a definite role in treating AA infections. However, still more long-term follow-up, studies are required for further validation of results and labelling it as a 100% cure for people suffering from AA with recurrences which are so common.

  9. Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia.

    Science.gov (United States)

    Upton, James H; Hannen, Rosalind F; Bahta, Adiam W; Farjo, Nilofer; Farjo, Bessam; Philpott, Michael P

    2015-05-01

    Dermal papilla cells (DPCs) taken from male androgenetic alopecia (AGA) patients undergo premature senescence in vitro in association with the expression of p16(INK4a), suggesting that DPCs from balding scalp are more sensitive to environmental stress than nonbalding cells. As one of the major triggers of senescence in vitro stems from the cell "culture shock" owing to oxidative stress, we have further investigated the effects of oxidative stress on balding and occipital scalp DPCs. Patient-matched DPCs from balding and occipital scalp were cultured at atmospheric (21%) or physiologically normal (2%) O2. At 21% O2, DPCs showed flattened morphology and a significant reduction in mobility, population doubling, increased levels of reactive oxygen species and senescence-associated β-Gal activity, and increased expression of p16(INK4a) and pRB. Balding DPCs secreted higher levels of the negative hair growth regulators transforming growth factor beta 1 and 2 in response to H2O2 but not cell culture-associated oxidative stress. Balding DPCs had higher levels of catalase and total glutathione but appear to be less able to handle oxidative stress compared with occipital DPCs. These in vitro findings suggest that there may be a role for oxidative stress in the pathogenesis of AGA both in relation to cell senescence and migration but also secretion of known hair follicle inhibitory factors.

  10. Clinical characteristics and HLA alleles of a family with simultaneously occurring alopecia areata.

    Science.gov (United States)

    Emre, Selma; Metin, Ahmet; Caykoylu, Ali; Akoglu, Gulsen; Ceylan, Gülay G; Oztekin, Aynure; Col, Esra S

    2016-06-01

    Alopecia areata (AA) is a T-cell-mediated autoimmune disease resulting in partial or total noncicatricial hair loss. HLA class II antigens are the most important markers that constitute genetic predisposition to AA. Various life events and intense psychological stress may play an important role in triggering AA attacks. We report an unusual case series of 4 family members who had simultaneously occurring active AA lesions. Our aim was to evaluate the clinical and psychiatric features of 4 cases of active AA lesions occurring simultaneously in a family and determine HLA alleles. The clinical and psychological features of all patients were examined. HLA antigen DNA typing was performed by polymerase chain reaction with sequence-specific primers. All patients had typical AA lesions over the scalp and/or beard area. Psychological examinations revealed obsessive-compulsive personality disorder in the proband's parents as well as anxiety and lack of self-confidence in both the proband and his sister. HLA antigen types were not commonly shared with family members. These findings suggest that AA presenting concurrently in members of the same family was not associated with genetic predisposition. Shared psychological disorders and stressful life events might be the major key points in the concurrent presentation of these familial AA cases and development of resistance against treatments.

  11. A Comparative Study of Oral Cyclosporine and Betamethasone Minipulse Therapy in the Treatment of Alopecia Areata

    Science.gov (United States)

    Jang, Yong Hyun; Kim, Sang Lim; Lee, Kyou Chae; Kim, Min Ji; Park, Kyung Hea; Lee, Weon Ju; Lee, Seok-Jong

    2016-01-01

    Background Various systemic agents have been assessed for the treatment of alopecia areata (AA); however, there is a paucity of comparative studies. Objective To assess and compare cyclosporine and betamethasone minipulse therapy as treatments for AA with regard to effectiveness and safety. Methods Data were collected from 88 patients who received at least 3 months of oral cyclosporine (n=51) or betamethasone minipulse therapy (n=37) for AA. Patients with ≥50% of terminal hair regrowth in the alopecic area were considered responders. Results The responder of the cyclosporine group was 54.9% and that of the betamethasone minipulse group was 37.8%. In the cyclosporine group, patients with mild AA were found to respond better to the treatment. Based on the patient self-assessments, 70.6% of patients in the cyclosporine group and 43.2% of patients in the betamethasone minipulse group rated their hair regrowth as excellent or good. Side effects were less frequent in the cyclosporine group. Conclusion Oral cyclosporine appeared to be superior to betamethasone minipulse therapy in terms of treatment effectiveness and safety. PMID:27746635

  12. Biomarkers of alopecia areata disease activity and response to corticosteroid treatment.

    Science.gov (United States)

    Fuentes-Duculan, Judilyn; Gulati, Nicholas; Bonifacio, Kathleen M; Kunjravia, Norma; Zheng, Xiuzhong; Suárez-Fariñas, Mayte; Shemer, Avner; Guttman-Yassky, Emma; Krueger, James G

    2016-04-01

    Alopecia areata (AA) is a common inflammatory disease targeting the anagen-stage hair follicle. Different cytokines have been implicated in the disease profile, but their pathogenic role is not yet fully determined. We studied biopsies of pretreatment lesional and non-lesional (NL) scalp and post-treatment (intra-lesional steroid injection) lesional scalp of 6 patchy patients with AA using immunohistochemistry and gene expression analysis. Immunohistochemistry showed increases in CD3(+) , CD8(+) T cells, CD11c(+) dendritic cells and CD1a(+) Langerhans cells within and around hair follicles of pretreatment lesional scalp, which decreased upon treatment. qRT-PCR showed in pretreatment lesional scalp (compared to NL) significant increases (P hair keratins in lesional scalp, with significant upregulation of KRT35, KRT75 and KRT86 in post-treatment lesional scalp. This study shows concurrent activation of Th1 and Th2 immune axes as well as IL-23 and IL-32 cytokine pathways in lesional AA scalp and defined a series of response biomarkers to corticosteroid injection. Clinical trials with selective antagonists coupled with cytokine-pathway biomarkers will be necessary to further dissect pathogenic immunity.

  13. 针药结合治疗斑秃研究现况%Research status on treating alopecia areata by acupuncture combined with medicine

    Institute of Scientific and Technical Information of China (English)

    刘倩

    2013-01-01

    Alopecia areata is one kind of sudden limitation alopecia on head. Systemic medication combined with local therapy was mainly used in modern medicine to treat alopecia areata. But the effect is not significant. TCM medicine has its own characteristics. The effect is more obvious than the modern medicine. Especially the combination of the acupuncture with medicine is worthy of clinical application.%斑秃一种突然发生的头部局限性脱发,西医在治疗斑秃方面多采用全身用药结合局部治疗为主,但疗效并不明显,中医在斑秃的治疗方法上有自己的特色,疗效也比西医明显,特别是针药结合治疗斑秃值得推广。

  14. 雄激素源性脱发的中医药研究进展%Chinese medicine treatment and research progress in androgenetic alopecia

    Institute of Scientific and Technical Information of China (English)

    杜雪萌; 孙世发

    2015-01-01

    通过收集国内近年来中医治疗雄激素源性脱发的研究文献,从中医理论的角度对雄激素源性脱发的病因病机、临床治疗、实验室研究方面进行归纳,旨在明确中医药治疗雄激素源性脱发的有效方法和药物。%Androgenetic alopecia is a common clinical disease. The pathogenesis of this disease is not clear, while TCM has achieved sound therapeutic effects on this disease by syndromes differentiation. By studying theory, the pathogenesis, clinical treatment and laboratory research of TCM treating the androgenetic alopecia in the past 10 years, we tried to provide reference for the treatment of androgenetic alopecia in Chinese medicine.

  15. Androgen dependence of hirsutism, acne, and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism.

    Science.gov (United States)

    Karrer-Voegeli, Sandra; Rey, François; Reymond, Marianne J; Meuwly, Jean-Yves; Gaillard, Rolf C; Gomez, Fulgencio

    2009-01-01

    Hirsutism, acne, alopecia, and oligo-amenorrhea are clinical expressions of hyperandrogenism, one of the most frequent endocrine disorders in women of reproductive age. Women referred to our endocrine clinics for skin symptoms of hyperandrogenism underwent a laboratory workup to evaluate hormone measurements and received antiandrogen therapy. We retrospectively analyzed the outcome of 228 consecutive patients investigated over 6 years.Patients with hirsutism had higher levels of androstenedione, dehydroepiandrosterone sulfate (DHEAS), and salivary testosterone; lower levels of sex hormone-binding globulin (SHBG); and a higher prevalence of oligo-amenorrhea than patients with alopecia, while patients with acne showed intermediate values. Hirsutism score correlated positively with androstenedione, DHEAS, and salivary testosterone, and correlated negatively with SHBG; salivary testosterone showed the highest correlation coefficient. Total testosterone was not significantly different among patients with hirsutism, alopecia, or acne, and did not significantly correlate with hirsutism score. Hirsutism and oligo-amenorrhea were the most sensitive symptoms of hyperandrogenism, and no androgenic parameter alone allowed us to identify all cases of hyperandrogenism.Patients of central European origin sought consultation with milder hirsutism scores than patients of southern European origin. There was, however, no difference in the clinical-biological correlation between these groups, arguing against differences in skin sensitivity to androgens.Polycystic ovary syndrome, defined as hyperandrogenism (hirsutism or elevated androgens) and oligo-amenorrhea, was diagnosed in 63 patients (27.6%), an underestimate compared with other reports that include systematic ovarian ultrasound studies. Neither pelvic ultrasound, used in a limited number of cases, nor the luteinizing hormone/follicle-stimulating hormone ratio helped to distinguish patients with polycystic ovary syndrome from

  16. Hair follicle stem cells in disorders characterized by alopecia%毛囊干细胞在脱发性疾病中的研究进展

    Institute of Scientific and Technical Information of China (English)

    管海宏; 李泓馨; 林麟

    2012-01-01

    Alopecia,as a common disease,is generally classified into two groups,cicatricial and noncicatricial alopecia,according to clinical presentations and regrowth capability of hairs,and each group includes various types of alopecia.The pathogenesis of alopecia remains poorly understood.Hair follicle stem cells are located in the bulge area,whose periodic proliferation and differentiation sustain the growth,shedding and regrowth of hairs.Recent research has indicated that the damage or deficiency of hair follicle stem cells may contribute to the pathogenesis of some types of alopecia,especially cicatricial alopecia.%脱发性疾病在临床比较常见,一般按临床表现和毛发是否可再生而将脱发分为瘢痕性脱发和非瘢痕性脱发,每种均包含了多种不同的脱发性疾病.目前脱发性疾病的发病机制仍不甚清楚.毛囊干细胞位于毛囊隆突区,其周期性地增殖和分化维持了毛发的正常生长、脱落与更替.研究表明,毛囊干细胞的损伤或缺失很可能参与了某些脱发性疾病尤其是瘢痕性脱发的发病过程.

  17. Serum levels of interleukin-1 (IL-1α, IL-1β in patients with alopecia areata

    Directory of Open Access Journals (Sweden)

    Emina Kasumagić-Halilovic

    2012-07-01

    Full Text Available Introduction: Alopecia areata (AA is disease characterized by focally, nonscarring hair loss on the scalp or other parts of the body. It affects 1-2% population of both genders and occurs at all age groups. The etiology is unknown, although most evidence supports the hypothesis that AA is a T-cell-mediated autoimmune disease of the hair follicle and that cytokines play an important role.Objective: The aim of our study was to evaluate serum concentrations of IL-1α and IL-1β in patients with AA and healthy subjects and also to asses a possible association between these cytokines and duration of the disease.Methods: Forty six patients with AA and 20 healthy controls were enrolled in the study. Serum concentrations of IL-1α and IL-1β were measured using enzyme-linked immunoassay techniques.Results: The serum level of IL-1α in patients with AA was significantly higher than that in the control group (4.34±0.86 pg/mL vs 3.66±0.35 pg/mL, respectively. IL-1β levels were greater in patients with AA than in controls (2.35±0.17 pg/mL vs 2.24±0.30, respectively but the difference was not significant (p>0.05. No correlations were found between duration of disease and the serum levels of IL-1α and IL-1β.Conclusion: Our results have demonstrated the importance of determining IL-1a concentration in serum in patients with AA. This research could contribute to the interpretation of insufficiently well known views of the pathogenesis role and significance of IL-1α in AA.

  18. 雄激素性秃发药物治疗进展%Advances in pharmacotherapy for androgenetic alopecia

    Institute of Scientific and Technical Information of China (English)

    王小珍; 刘政邑; 徐宏俊; 张建中

    2012-01-01

    雄激素性秃发(androgenetic alopecia AGA)是一种雄激素依赖的遗传性疾病,特征为头顶部毛发进行性减少.在药物治疗上主要是以口服非那雄胺和外用米诺地尔为主,近些年在治疗AGA 的药物上有新的发现,该文就近年来药物治疗雄激素性秃发作一综述.

  19. "Células-tronco foliculares na alopecia difusa não-cicatricial de pacientes HIV positivos"

    OpenAIRE

    2005-01-01

    A alopecia difusa não-cicatricial (ADNC) acomete 7% dos pacientes HIV positivos. O objetivo deste trabalho foi comparar os achados histológicos e imunohistoquímicos (citoqueratina 19/TUNEL e caspase 3 clivada) em cortes transversais de couro cabeludo de 15 pacientes HIV-1 positivos com ADNC e de 12 controles sadios. A apoptose de células tronco-foliculares e amplificadoras transitórias na protuberância folicular foi demonstrada pela dupla marcação TUNEL/CK19 em 80% dos casos e em 25% dos cont...

  20. Health-related quality of life (HRQoL) among patients with alopecia areata (AA): A systematic review.

    Science.gov (United States)

    Liu, Lucy Y; King, Brett A; Craiglow, Brittany G

    2016-10-01

    Alopecia areata (AA) is a common skin disease that is frequently emotionally devastating. Several studies have examined the effect of AA on health-related quality of life (HRQoL). We performed a systematic review of all published studies of HRQoL in patients with AA. Eleven studies met inclusion criteria, incorporating data from 1986 patients. Patients with AA consistently demonstrate poor HRQoL scores, with greater extent of scalp involvement associated with lower HRQoL. HRQoL experienced by patients with AA is similar to that seen in patients with other chronic skin diseases including atopic dermatitis and psoriasis.

  1. Four Diseases, Two Associations, One Patient: A Case of Frontal Fibrosing Alopecia, Lichen Planus Pigmentosus, Acne Rosacea, and Morbihan Disease.

    Science.gov (United States)

    Walker, Joanna L; Robinson-Bostom, Leslie; Landow, Shoshana

    2016-01-01

    A 77-year-old woman born in the Dominican Republic presented with fullness of the glabella and medial eyebrows for 1 year followed by alopecia of the lateral eyebrows and frontal hairline. She stated that although she had a high hairline at baseline, it had receded in the past year. She had also noted central scalp hair thinning that started 6 years earlier. She denied all styling practices that used traction or chemical processes, although she admitted to hair dye and blow dryer use. She reported "acne" in the central face for decades and darkening of the skin on the lateral face for several years. Her medical history included hypertension, hyperlipidemia, hypothyroidism, benign paroxysmal positional vertigo, and treated breast ductal hyperplasia. Her medications were metoprolol, amlodipine, aspirin, levothyroxine, omeprazole, pravastatin, and meclizine; she denied starting any new medications within the past 2 years. Her family history was notable for androgenic pattern alopecia in a brother and a high hairline in her father. Review of systems was negative except for knee arthralgias and seasonal allergic rhinitis.

  2. Alopecia areata ofiásia na infância: do diagnóstico ao tratamento

    Directory of Open Access Journals (Sweden)

    José Otávio Alquezar Gozzano

    2016-10-01

    Full Text Available Introdução: Entre as alopecias mais comuns na infância está a alopecia areata (AA, uma afecção crônica dos folículos pilosos, de etiologia auto-imune e genética. Apresenta-se pela queda de pelos, devido a interrupção de sua síntese, sem a atrofia dos folículos, por isso é reversível. AA afeta ambos os sexos e inicia- se em qualquer idade; porém, 60% dos primeiros episódios ocorrem entre 5 e 20 anos. AA manifesta-se por placas de alopecia assintomáticas, arredondadas, sem inflamação, podendo afetar qualquer área com folículos pilosos, frequentemente o couro cabeludo. Sinal de tração positivo, pelos cadavéricos e penugem branca no exame físico da fase aguda auxiliam o diagnóstico. AA é classificada como atípica e clássica, esta última pode ser: placa única, placas múltiplas, AA total, ou AA ofiásica (AAO. AAO consiste na perda de cabelos na linha de implantação temporooccipital, atingindo as bordas inferiores do couro cabeludo; seu diagnóstico é clinico devendo ser diferenciado de Tinha do couro cabeludo, pseudopelada de Brocq e tricotilomania. O tratamento para AAO é sintomático e não altera o prognóstico, sendo utilizados principalmente corticoides tópicos, infiltrações intralesionais, antralina e minoxidil. Objetivo: Relatar caso de AAO na infância. Relato do caso: Feminina, 13 anos, com perda de cabelos há 4 anos e piora há 6 meses. Ao exame: área extensa de alopecia em região temporoocciptal até margem inferior de implantação do couro cabeludo. Sinal de tração positivo na periferia da área de alopecia. Hipótese diagnóstica: AAO. Terapia: infiltração de corticoide. Metodologia: Paciente atendida em ambulatório e revisão de literatura. Conclusão: Por acometer sobretudo os cabelos, AA afeta a autoestima e os aspectos psicológicos, principalmente das crianças, que crescem em meio propício a julgamentos e rejeição social. Assim, é importante a intervenção terapêutica precoce

  3. Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.

    Science.gov (United States)

    Gilhar, Amos; Schrum, Adam G; Etzioni, Amos; Waldmann, Herman; Paus, Ralf

    2016-07-01

    One of the most common human autoimmune diseases, alopecia areata (AA), is characterized by sudden, often persisting and psychologically devastating hair loss. Animal models have helped greatly to elucidate critical cellular and molecular immune pathways in AA. The two most prominent ones are inbred C3H/HeJ mice which develop an AA-like hair phenotype spontaneously or after experimental induction, and healthy human scalp skin xenotransplanted onto SCID mice, in which a phenocopy of human AA is induced by injecting IL-2-stimulated PBMCs enriched for CD56+/NKG2D+ cells intradermally. The current review critically examines the pros and cons of the available AA animal models and how they have shaped our understanding of AA pathobiology, and the development of new therapeutic strategies. AA is thought to arise when the hair follicle's (HF) natural immune privilege (IP) collapses, inducing ectopic MHC class I expression in the HF epithelium and autoantigen presentation to autoreactive CD8+ T cells. In common with other autoimmune diseases, upregulation of IFN-γ and IL-15 is critically implicated in AA pathogenesis, as are NKG2D and its ligands, MICA, and ULBP3. The C3H/HeJ mouse model was used to identify key immune cell and molecular principles in murine AA, and proof-of-principle that Janus kinase (JAK) inhibitors are suitable agents for AA management in vivo, since both IFN-γ and IL-15 signal via the JAK pathway. Instead, the humanized mouse model of AA has been used to demonstrate the previously hypothesized key role of CD8+ T cells and NKG2D+ cells in AA pathogenesis and to discover human-specific pharmacologic targets like the potassium channel Kv1.3, and to show that the PDE4 inhibitor, apremilast, inhibits AA development in human skin. As such, AA provides a model disease, in which to contemplate general challenges, opportunities, and limitations one faces when selecting appropriate animal models in preclinical research for human autoimmune diseases.

  4. Comparative study of intralesional steroid injection and cryotherapy in alopecia areata

    Directory of Open Access Journals (Sweden)

    Mehdi Amirnia

    2015-01-01

    Full Text Available Background and Objectives: Alopecia areata (AA is a common, non-scarring type of hair loss, affecting approximately 2.1% of the population, many modality of treatment recommended like steroid injection, topical Immunotherapy and several systemic therapies. The aim of this study was to compare intralesional steroid injection and cryotherapyoutcomes in AA. Materials and Methods: In an analytical-descriptive study, 120 AA patients treated with intralesionalsteroid injection and 120 AA patients treated with cryotherapy were randomly selected. These two groups matched for location, duration and size of lesion and also matched for age and gender.From March 2011 to September 2013, the effect and complications of the therapies after 3, 6, 9 and 12 weeks were assessed and results were compared between the two groups. Results: Mean age of patients in steroid injection group was 30.2 ± 6.8 and in cryotherapy group was 31.8 ± 7.1. Sexual distribution in both groups was 56.7% and 43.3 % for male and female, respectively.Location of disease in 80% was in scalp and 20% was in face in both groups. The time of beginning response in steroid group was 4.13 ± 2.13 weeks and in cryotherapy group was 6.14 ± 0.29 weeks, difference between two groups was significant (P = 0.001. In term of clinical response at the end of study,in steroid group,20 patients (16.7% no response, 32 patients (26.7%, moderate response and68 patients (56.7% had a complete response, and also in cryotherapy group was, 52 patients (43.3% no response, 40 patients (33.3% moderate response and 28 patients (23.3% had a complete response. There was significant different in complete response rate and steroid injection was more effective than cryotherapy(P < 0.05. Conclusion: As the cryotherapy isa considerable treatment of AA, alsothis study proposes intralesional injection of corticosteroid,as a replacement of AA therapy; particularly the short-term complications are not significantly different.

  5. Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes.

    Science.gov (United States)

    Tang, Liren; Cao, Liping; Bernardo, Olga; Chen, Yongliang; Sundberg, John P; Lui, Harvey; Chung, Stephen; Shapiro, Jerry

    2003-03-01

    Alopecia areata is an autoimmune disease targeted at hair follicles with infiltrated T lymphocytes probably playing an important role in the pathogenesis. It was reported in 1985 that mechlorethamine was effective on alopecia areata patients. This has never been confirmed since. The aims of the study were to investigate the effects of mechlorethamine on balding C3H/HeJ mice affected with an alopecia-areata-like disease and to study the underlying mechanisms. Mice were treated on half of the dorsal skin with mechlorethamine and the contralateral side was treated with the vehicle ointment. After 10 wk of mechlorethamine therapy, a full pelage of hair covered the treated side in all the mice and was maintained during the study, whereas the vehicle-treated sides showed either no change or continued hair loss. Immunohistochemistry revealed that infiltrated CD4+ and CD8+ lymphocytes were eliminated from the treated side. In vitro cell viability assay showed that lymphocytes were much more sensitive to the cytotoxic effects of mechlorethamine than skin and hair follicular cells. RNase protection assay and real-time reverse transcription polymerase chain reaction showed that tumor necrosis factor alpha/beta, interleukin-12, and interferon-gamma were inhibited by mechlorethamine upon successful treatment. Our findings support that mechlorethamine restores follicular activity by selectively targeting infiltrated lymphocytes in vivo in alopecia-areata-affected mice.

  6. Total Glucosides of Paeony Capsule Plus Compound Glycyrrhizin Tablets for the Treatment of Severe Alopecia Areata in Children: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Dingquan Yang

    2013-01-01

    Full Text Available Total glucosides of paeony capsule (TGPC and compound glycyrrhizin tablets (CGT are plant extracts of glycosides. We conducted this study to examine the efficacy and safety of TGPC plus CGT for severe alopecia areata in children. 117 subjects were randomly allocated into TGPC plus CGT group or CGT group. For consecutive 12 months, subjects were given oral TGPC and CGT or oral CGT alone. The outcome measures included score of alopecia areata severity, effective rate, and adverse events observed in the 3rd, 6th, and 12th month. We found that the scores of alopecia areata severity of both groups were significantly reduced, and the scores of treatment group were lower than those of control group; for effective rate, there was no statistical difference between the two groups in the 3rd month, while in the 6th and 12th months the treatment group was superior compared with control group; the incidence rate of adverse events between the two groups was not statistically different, and no severe adverse events were observed. In conclusion, TGPC plus CGT appears effective and safe for severe alopecia areata in children.

  7. Estudio preliminar de prevención de la alopecia en las cejas mediante la administración de gel frío en pacientes con cáncer de mama sometidas a quimioterapia adyuvante/neoadyuvante

    OpenAIRE

    2015-01-01

    Introducción y objetivos La alopecia inducida por quimioterapia constituye uno de los efectos adversos más frecuentemente inducidos por el tratamiento en pacientes con Cáncer de Mama (CM). La alopecia de las cejas, produce un importante impacto en la autoimagen, no existiendo en la actualidad tratamientos eficaces que eviten su aparición. Basándonos en la evidencia sobre la prevención de la alopecia en cuero cabelludo mediante la administración de frío, se diseñó un estudio piloto de preve...

  8. Analysis on Blood Zinc Levels in 751 Children with Alopecia Areata%751例斑秃儿童血锌含量的分析

    Institute of Scientific and Technical Information of China (English)

    伊长英; 范美丽; 王玲

    2014-01-01

    Objective To explore the relationship between blood zinc level and alopecia areata in children. Methods 751 children with alopecia areata and 201 healthy controls were collected, and then blood zinc levels were tested by use of an automatic elemental analyzer in all subjects. Results Blood zinc level in alopecia areata group was (67.46±12.43)µmol/L, lower significantly than (76.03±9.23)µmol/L in control group (P<0.01). Conclusion Lower blood zinc level may be associated with alopecia areata in children, trace element zinc should be detected and supplemented in the diagnosis and treatment of alopecia areata in children.%目的:探讨儿童斑秃与血锌含量的关系。方法选取临床已确诊的斑秃751例为斑秃组,同时选取同期健康查体儿童201例为对照组,采用全血多元素分析仪进行血锌检测。结果斑秃组血锌含量为(67.46±12.43)µmol/L,显著低于对照组(76.03±9.23)µmol/L(P<0.01)。结论儿童斑秃可能与血锌降低有关,儿童斑秃的诊疗中应注意微量元素锌的检测和补充。

  9. 脱发发病机理与防治药物新进展%Advances in the pathology and pharmacology of alopecia

    Institute of Scientific and Technical Information of China (English)

    韩向晖; 李经才

    2001-01-01

    Being the progresses of biological medicine in recent years, it achieved the possibility to elucidate the pathogenesis and to develop new drugs of alopecia in cellular and molecular level. The traditional Chinese medicine, which attaches importance to the influence of environmental and psychical factor to alopecia, has promoted great achievement in prescription treatment for alopecia. This paper reviewed the progress in the recent study of the most common baldness-alopecia areata and androgenic alopecia on the pathogenesis and treatment by traditional Chinese medicine and western medicine respectively.%近年由于细胞分子生物学的发展,两类常见脱发病—斑秃和脂溢性脱发的病理病因和治疗药物有重大进展。斑秃的发病与免疫、细胞因子、神经内分泌有关,局部免疫治疗和应用免疫抑制剂FK506是治疗斑秃较为理想的方法。脂溢性脱发受遗传和雄激素双重影响,5-α还原酶抑制剂和米诺地尔是目前较好的治疗药物。中医从整体出发,分析脱发的病理病机,开发出一系列有效的治疗方剂。采用中西医结合治疗脱发具有广阔前景。

  10. Syndrome Differentiation and Treatment Experience of Alopecia Areata%审证求因治疗斑秃

    Institute of Scientific and Technical Information of China (English)

    周宝宽

    2011-01-01

    Objective:To summarize syndrome differentiation and treatment experience of alopecia areata in clinic. Methods : Discuss etiopathogenisis, pathogenesis, pattern of syndrome, method of treatment, formulas and medicinals based on medical records. Results: Etiopathogenisis and pathogenesis of alopecia areata include fire-syndrome resulting from depression, or peacetime calor internus, heat in blood wind generating wind result in blood heat wind-dryness syndrome; stagnation of QI due to depression of the liver, macronosia blood stasis, obstruction of collaterals by blood stasis result in syndrome of qi-stagnancy and blood stasis; spleen and stomach damage, macronosia result in deficiency of both QI and blood, blood not nurshing hairs result in syndrome of deficiency of both QI and blood; macronosia result in deficiency of liver and kidey, blood not nurshing hairs result in syndrome of deficiency of liver and kidey. Frequently used decoction is Liangxue Xiaofeng San, Tongqiao Huoxue Tang, Renshen Yangrong Tang, Qibao Meiran Dan. Conclusions : Syndrome differentiation and treatment shows a better therapeutic effect for alopecia areata.%目的:总结周宝宽主任医师辨证论治斑秃经验.方法:以医案形式阐述斑秃的病因病机、证型、治法、方药.结果:斑秃病因病机为抑郁化火,或素体内热,血热生风形成血热风燥证;肝郁气滞,或久病成瘀,瘀血阻络形成气滞血瘀证;脾胃损伤,或久病气血两虚,血不养发形成气血两虚证;病程日久,肝肾亏虚,血不养发形成肝肾不足证.常用方药为凉血消风散、通窍活血汤、人参养荣汤、七宝美髯丹.结论:辨证论治斑秃疗效显著.

  11. 斑秃发病机制的研究进展%Updates on the Pathogenesis of Alopecia Areata

    Institute of Scientific and Technical Information of China (English)

    杨淑霞

    2016-01-01

    斑秃(alopecia areata,AA)是一种常见的非瘢痕性脱发性疾病,发病率约为1% ~2%.AA的发病机理尚未完全明确,目前普遍认为这是一种因毛囊免疫豁免机制被破坏而引发的器官特异性的、T细胞介导的自身免疫病.在AA的发病中还涉及了多种遗传因素和环境因素的共同作用.文中综述概括了AA发病机制的研究进展.

  12. 雄激素源性脱发治疗进展%Treatment progress of androgenic alopecia

    Institute of Scientific and Technical Information of China (English)

    张大维; 陈前明

    2009-01-01

    @@ 雄激素源性脱发(androgenic alopecia,AGA)[1]又称早秃、男性型脱发,因往往伴有皮脂溢出,既往曾称之为脂溢性脱发,中医学称为油风、蛀发癣.男女均可发病,但以20~30岁的男性较为多见,表现为头部皮肤油腻、脱屑,可伴瘙痒,额颞区及顶部渐进性脱发,继而形成高额,而枕区较少累及.

  13. Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report

    Science.gov (United States)

    Ferreira, Sineida Berbert; Scheinberg, Morton; Steiner, Denise; Steiner, Tatiana; Bedin, Gustavo Longhi; Ferreira, Rachel Berbert

    2016-01-01

    Alopecia areata (AA) is a chronic, autoimmune disease. The main symptom is massive hair loss, localized or diffuse, in the scalp and the whole body. However, nails may also be involved, and brittleness, fragility and pitting can be signs of nail dystrophy in AA patients. Here, we report the case of a male patient with AA refractory to various treatments, including oral, topical and intralesional corticosteroids, immunosuppressants, cyclosporin and PUVA (oxoralen plus ultraviolet light), all interrupted due to side effects. The patient's nails had erythematous blotches (striated lunulae) with regular and superficial pitting as well as fragility (trachyonychia), and he could no longer play the guitar because of these symptoms. With patient consent, we introduced tofacitinib (5 mg twice daily), which resulted in remarkable improvements not only regarding hair regrowth but also nail changes, with function recovery within 10 months. PMID:28101018

  14. Mural folliculitis and alopecia caused by infection with goat-associated malignant catarrhal fever virus in two sika deer.

    Science.gov (United States)

    Crawford, Timothy B; Li, Hong; Rosenburg, Stuart R; Norhausen, Robert W; Garner, Michael M

    2002-09-15

    Two sika deer from a zoo in Florida were examined because of chronic hair loss and skin lesions. No common causes of alopecia were identified in either deer. One deer was treated with prednisone, but the condition worsened when the dosage was decreased. Both deer were euthanatized after several months because of continued disease. The predominant histologic lesion in skin specimens was granulomatous mural folliculitis. Serologic testing and sequencing of fragments produced with a consensus polymerase chain reaction assay indicated that both deer were infected with caprine herpesvirus-2, a newly recognized member of the malignant catarrhal fever group of viruses. Disease in these deer was substantially different from that typically seen following infection with ovine herpesvirus-2, the sheep-associated malignant catarrhal fever virus. Findings in these deer establish the pathogenicity of caprine herpesvirus-2 in sika deer and illustrate the ability of this group of complex herpesviruses to cause a wide variety of clinical abnormalities in diverse species.

  15. The role of cytokines and chemokines in the T-cell-mediated autoimmune process in alopecia areata.

    Science.gov (United States)

    Ito, Taisuke; Tokura, Yoshiki

    2014-11-01

    The aetiology of alopecia areata (AA) is still not fully understood. However, recent clinical and experimental studies have provided insights into the pathomechanisms of AA and revealed that it is an organ-specific and cell-mediated autoimmune disease. Some triggers, such as viral infections, trauma, hormones and emotional/physical stressors, may cause activation of autoreactive T cells that target hair follicle (HF) autoantigens. In these immunological responses, cytokines and chemokines are regarded as key players that mediate the autoimmune inflammation. This results in the collapse of HF immune privilege, which is central to the pathogenesis of AA. This essay will focus on how cytokines and chemokines contribute to the immunological aspects of AA. The management of AA often remains difficult in a number of cases. Our review suggests that novel therapies for AA may involve targeting cytokines and chemokines.

  16. Androgenic alopecia is associated with less dietary soy, lower [corrected] blood vanadium and rs1160312 1 polymorphism in Taiwanese communities.

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    Ching-Huang Lai

    Full Text Available Although the genetic basis of androgenic alopecia has been clearly established, little is known about its non-genetic causes, such as environmental and lifestyle factors.This study investigated blood and urine heavy metals concentrations, environmental exposure factors, personal behaviors, dietary intakes and the genotypes of related susceptibility genes in patients with androgenic alopecia (AGA.Age, AGA level, residence area, work hours, sleep patterns, cigarette usage, alcohol consumption, betel nut usage, hair treatments, eating habits, body heavy metals concentrations and rs1998076, rs913063, rs1160312 and rs201571 SNP genotype data were collected from 354 men. Logistic regression analysis was performed to examine whether any of the factors displayed odds ratios (ORs indicating association with moderate to severe AGA (≥ IV. Subsequently, Hosmer-Lemeshow, Nagelkerke R(2 and accuracy tests were conducted to help establish an optimal model.Moderate to severe AGA was associated with the AA genotype of rs1160312 (22.50, 95% CI 3.99-126.83, blood vanadium concentration (0.02, 95% CI 0.01-0.04, and regular consumption of soy bean drinks (0.23, 95% CI 0.06-0.85, after adjustment for age. The results were corroborated by the Hosmer-Lemeshow test (P = 0.73, Nagelkerke R(2 (0.59, accuracy test (0.816 and area under the curve (AUC; 0.90, 0.847-0.951 analysis.Blood vanadium and frequent soy bean drink consumption may provide protect effects against AGA. Accordingly, blood vanadium concentrations, the AA genotype of rs1160312 and frequent consumption of soy bean drinks are associated with AGA.

  17. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period

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    Maria-Angeliki Gkini

    2014-01-01

    Full Text Available Background: Platelet-rich plasma (PRP is defined as an autologous concentration of plasma with a greater count of platelets than that of whole blood. Its action depends on the released growth factors from platelets. It has been investigated and used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss. Aims: To evaluate the efficacy and safety of PRP injections in the scalp of patients with androgenetic alopecia. Settings and Design: Prospective cohort study. Materials and Methods: 20 patients, 18 males and 2 females, with androgenetic alopecia were enrolled in the study. PRP was prepared using a single spin method (Regenlab SA. Upon activation, it was injected in the androgen-related areas of scalp. Three treatment sessions were performed with an interval of 21 days and a booster session at 6 months following the onset of therapy. Statistical Analysis: Statistical analysis of the data was performed using the Statistical Package for the Social Sciences (SPSS, version 19.0 (IBM, NY, USA. Results: Hair loss reduced and at 3 months it reached normal levels. Hair density reached a peak at 3 months (170.70 ± 37.81, P < 0.001. At 6 months and at 1 year, it was significantly increased, 156.25 ± 37.75 (P < 0.001 and 153.70 ± 39.92 (P < 0.001 respectively, comparing to baseline. Patients were satisfied with a mean result rating of 7.1 on a scale of 1-10. No remarkable adverse effects were noted. Conclusions: Our data suggest that PRP injections may have a positive therapeutic effect on male and female pattern hair loss without remarkable major side effects. Further studies are needed to confirm its efficacy.

  18. Differences Between the Treatment For Men and Women Alopecia%脱发治疗之男女差异浅谈

    Institute of Scientific and Technical Information of China (English)

    孙成力; 陆文; 高建东; 肖静

    2012-01-01

    Treatment for alopecia is seldom effective. According to the physical differences between men and women, inspired by the clinical and review of the Medical literature, we focus on nourishing blood for women or eliminating dampness for men in the alopecia treatment, combined with invigorating the kidney, as well as diet recuperation and external washing method, and we achieved good effect.%脱发治疗往往收效甚缓.结合临床和文献复习,我们根据男女体质的差异,在治疗上分别侧重养血和祛湿等不同方面,佐以补肾,并配合饮食调养和外洗法,取得了较好疗效.

  19. Clinicopathological analysis of 53 cases of cicatricial alopecia%53例瘢痕性秃发的临床和病理特点分析

    Institute of Scientific and Technical Information of China (English)

    戚世玲; 赵莹; 张小婷; 张斌; 杨建; 章星琪

    2013-01-01

    目的 探讨瘢痕性脱发的临床、组织病理与皮肤镜特点,以及治疗和预后的特征.方法 回顾性分析53例瘢痕性脱发患者的临床资料,分析其组织病理、皮肤镜征象、治疗和预后的特点.结果 瘢痕性脱发以脱发、毛囊开口消失、毛囊皮脂腺单位数目减少或消失为共同特征.基底细胞局灶液化变性、毛囊角栓、毛细血管分支状扩张、免疫荧光阳性提示盘状红斑狼疮;界面皮炎提示毛发扁平苔藓;炎症和弹力纤维轻微破坏提示假性斑秃;毛囊间黏蛋白沉积及毛囊口下陷为黏蛋白性脱发的特点;脓疱可见于脱发性毛囊炎和分割性蜂窝织炎或毛囊炎,前者多伴有簇状发,窦道形成则仅见于后者.治疗对淋巴细胞性患者使用免疫抑制剂,对中性粒细胞性患者使用抗生素和维A酸.结论 组织病理检查对诊断起决定性作用.瘢痕性脱发造成不可逆的毛囊损害,治疗周期长.早期诊断及早期合理用药可控制疾病发展,减少永久性脱发损害.%Objective To investigate the clinical,histopathological and dermoscopic features as well as treatment and prognosis of cicatricial alopecia.Methods Clinical data on 53 patients with cicatricial alopecia were retrospectively collected and studied.Pathological and dermoscopic characteristics,as well as treatment modality and prognosis of cicatricial alopecia were analyzed.Results Cicatricial alopecia was characterized by alopecia,disappearance of follicular ostia,and absence or decrease in the number of polisebaceous gland units.Pathologically,focal liquefactive degeneration of basal cells,follicular keratotic plugs,arborising telangiectasia together with a positive immunofluorescence test were usually suggestive of discoid lupus erythematosus,interface dermatitis suggestive of lichen planopilaris,inflammation and mild disruption of elastic fibers suggestive of classic pseudopelade of Brocq.Mucin deposition between hair

  20. Androgenetic alopecia: new insights into the pathogenesis and mechanism of hair loss [v1; ref status: indexed, http://f1000r.es/5ar

    Directory of Open Access Journals (Sweden)

    Rodney Sinclair

    2015-08-01

    Full Text Available The hair follicle is a complete mini-organ that lends itself as a model for investigation of a variety of complex biological phenomena, including stem cell biology, organ regeneration and cloning.  The arrector pili muscle inserts into the hair follicle at the level of the bulge- the epithelial stem cell niche.  The arrector pili muscle has been previously thought to be merely a bystander and not to have an active role in hair disease. Computer generated 3D reconstructions of the arrector pili muscle have helped explain why women with androgenetic alopecia (AGA experience diffuse hair loss rather than the patterned baldness seen in men.  Loss of attachment between the bulge stem cell population and the arrector pili muscle also explains why miniaturization is irreversible in AGA but not alopecia areata. A new model for the progression of AGA is presented.

  1. 刘爱民教授治疗复发性斑秃的经验%Experience of Prof. LIU Ai-min for treating recurrent alopecia areate

    Institute of Scientific and Technical Information of China (English)

    李静; 刘爱民; 吴姣美; 张琳琳

    2014-01-01

    Prof. LIU is experienced in the treatment of recurrent alopecia areate and has uniquemethods. The clinical efficacy is satisfactory. The methods should be widely applied.%刘爱民教授治疗复发性斑秃经验丰富,选方用药有其独到之处,临床效果满意,值得推广应用。

  2. A novel locus for alopecia with mental retardation syndrome (APMR2) maps to chromosome 3q26.2-q26.31.

    Science.gov (United States)

    Wali, A; John, P; Gul, A; Lee, K; Chishti, M S; Ali, G; Hassan, M J; Leal, S M; Ahmad, W

    2006-09-01

    Congenital alopecia may occur either alone or in association with ectodermal and other abnormalities. On the bases of such associations, several different syndromes featuring congenital alopecia can be distinguished. Alopecia with mental retardation syndrome (APMR) is a rare autosomal recessive disorder, clinically characterized by total or partial hair loss and mental retardation. In the present study, a five-generation Pakistani family with multiple affected individuals with APMR was ascertained. Patients in this family exhibited typical features of APMR syndrome. The disease locus was mapped to chromosome 3q26.2-q26.31 by carrying out a genome scan followed by fine mapping. A maximum two-point logarithm of odds (LOD) score of 2.93 at theta=0.0 was obtained at markers D3S3053 and D3S2309. Multipoint linkage analysis resulted in a maximum LOD score of 4.57 with several markers, which supports the linkage. The disease locus was flanked by markers D3S1564 and D3S2427, which corresponds to 9.6-cM region according to the Rutgers combined linkage-physical map of the human genome (build 35) and contains 5.6 Mb. The linkage interval of the APMR locus identified here does not overlap with the one described previously; therefore, this locus has been designated as APMR2.

  3. Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial.

    Science.gov (United States)

    Choi, Jae-Suk; Park, Jae Beom; Moon, Woi-Sook; Moon, Jin-Nam; Son, Sang Wook; Kim, Mi-Ryung

    2015-01-01

    We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO2 extract (RB-SCE) in the treatment of androgenic alopecia. Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental group received a dermal application of 0.5% RB-SCE (8 mL/d) to the head skin for 16 weeks while the control group received a dermal application of placebo. Changes in hair count, diameter, and density were evaluated with a Folliscope(®). Patient satisfaction was evaluated via questionnaire and clinical photographs were rated by dermatologists. The results showed that RB-SCE significantly increased hair density and hair diameter in male subjects. Patient satisfaction and the evaluation of photographs by dermatologists also confirmed the effectiveness of RB-SCE in the treatment of alopecia. No adverse reactions related to RB-SCE were reported. Therefore, RB-SCE shows promise for use in functional cosmetics and pharmaceuticals.

  4. Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil in the treatment of female androgenetic alopecia.

    Science.gov (United States)

    Roberts, Janet; Desai, Nisha; McCoy, John; Goren, Andy

    2014-01-01

    Two percent topical minoxidil is the only US Food and Drug Administration-approved drug for the treatment of female androgenetic alopecia (AGA). Its success has been limited by the low percentage of responders. Meta-analysis of several studies reporting the number of responders to 2% minoxidil monotherapy indicates moderate hair regrowth in only 13-20% of female patients. Five percent minoxidil solution, when used off-label, may increase the percentage of responders to as much as 40%. As such, a biomarker for predicting treatment response would have significant clinical utility. In a previous study, Goren et al. reported an association between sulfotransferase activity in plucked hair follicles and minoxidil response in a mixed cohort of male and female patients. The aim of this study was to replicate these findings in a well-defined cohort of female patients with AGA treated with 5% minoxidil daily for a period of 6 months. Consistent with the prior study, we found that sulfotransferase activity in plucked hair follicles predicts treatment response with 93% sensitivity and 83% specificity. Our study further supports the importance of minoxidil sulfation in eliciting a therapeutic response and provides further insight into novel targets for increasing minoxidil efficacy.

  5. Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology.

    Science.gov (United States)

    Heilmann, Stefanie; Kiefer, Amy K; Fricker, Nadine; Drichel, Dmitriy; Hillmer, Axel M; Herold, Christine; Tung, Joyce Y; Eriksson, Nicholas; Redler, Silke; Betz, Regina C; Li, Rui; Kárason, Ari; Nyholt, Dale R; Song, Kijoung; Vermeulen, Sita H; Kanoni, Stavroula; Dedoussis, George; Martin, Nicholas G; Kiemeney, Lambertus A; Mooser, Vincent; Stefansson, Kari; Richards, J Brent; Becker, Tim; Brockschmidt, Felix F; Hinds, David A; Nöthen, Markus M

    2013-06-01

    The pathogenesis of androgenetic alopecia (AGA, male-pattern baldness) is driven by androgens, and genetic predisposition is the major prerequisite. Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms (SNPs) at eight different genomic loci are associated with AGA development. However, a significant fraction of the overall heritable risk still awaits identification. Furthermore, the understanding of the pathophysiology of AGA is incomplete, and each newly associated locus may provide novel insights into contributing biological pathways. The aim of this study was to identify unknown AGA risk loci by replicating SNPs at the 12 genomic loci that showed suggestive association (5 × 10(-8)

  6. Baldness and the androgen receptor: the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia.

    Science.gov (United States)

    Ellis, Justine A; Scurrah, Katrina J; Cobb, Joanna E; Zaloumis, Sophie G; Duncan, Anna E; Harrap, Stephen B

    2007-05-01

    Androgenetic alopecia, or male pattern baldness, is a complex condition with a strong heritable component. In 2001, we published the first significant evidence of a genetic association between baldness and a synonymous coding SNP (rs6152) in the androgen receptor gene, AR. Recently, this finding was replicated in three independent studies, confirming an important role for AR in the baldness phenotype. In one such replication study, it was claimed that the causative variant underlying the association was likely to be the polyglycine (GGN) repeat polymorphism, one of two apparently functional triplet repeat polymorphisms located in the exon 1 transactivating domain of the gene. Here, we extend our original association finding and present comprehensive evidence from approximately 1,200 fathers and sons drawn from 703 families of the Victorian Family Heart Study, a general population Caucasian cohort, that neither exon 1 triplet repeat polymorphism is causative in this condition. Seventy-eight percent of fathers (531/683) and 30% of sons (157/520) were affected to some degree with AGA. We utilised statistical methods appropriate for the categorical nature of the phenotype and familial structure of the cohort, and determined that whilst SNP rs6152 was strongly associated with baldness (P baldness, but also for the many other complex conditions that have thus far been linked to AR.

  7. 雄激素性秃发治疗进展%The therapeutic progress of androgenetic alopecia

    Institute of Scientific and Technical Information of China (English)

    郭金竹; 李邻峰

    2012-01-01

    雄激素性秃发是最常见的一种脱发,在基因易感的女性也同样常见.该文总结了针对男性和女性雄激素性秃发的内服药物(如非那雄胺、异维A酸、氟他胺、激素疗法等)、外用药物(如米诺地尔、非那雄胺凝胶等)、毛发移植和物理治疗(高压氧及激光)等治疗方法的原理、用法、不良反应等最新进展.%Androgenetic alopecia (AGA) is one of the most common causes of hair loss both in genetically susceptible women and men-Here, we review the different treatments of male and female pattern, such as medical treatment (finasteride, 13-cis-retinoic acid, flutamide, hormonotherapy, etc), topical treatment (minoxidil, finasteride gel, etc.), hair transplantation and physical treatment (hyperbaric oxygen and laser), including the progress of therapeutic mechanism, dosage and adverse reaction.

  8. Study of the international epidemiology of androgenetic alopecia in young caucasian men using photographs from the internet

    Directory of Open Access Journals (Sweden)

    Yaniv Shalom Avital

    2015-01-01

    Full Text Available Background: The epidemiological evaluation of androgenetic alopecia (AGA is based mainly on direct observation and questionnaires. The international epidemiology and environmental risk factors of AGA in young Caucasian men remain unknown. Aim: To use photographs and data from the Internet to evaluate severe AGA and generate greater understanding of the international epidemiology of the disorder in young Caucasian men. Materials and Methods: A population-based cross-sectional study design was used. The sample included 26,340 Caucasian men aged 30 to 40 years who had uploaded profiles to two dating websites. Their photographs were evaluated for AGA and graded as follows: severe AGA (Norwood type VI-VII, non-severe AGA, and unknown. Epidemiological data were collected from the sites. Logistic regression was used to analyze the effect of risk factors on the prevalence of severe AGA. Results : The overall success rate for identifying severe AGA by indirect evaluation of Internet photographs was 94%. The prevalence of severe AGA was 15.33% overall and varied significantly by geographical region. The risk of having severe AGA was increased by 1.092 for every year of age between 30 and 40 years. Severe AGA was more prevalent in subjects with higher body mass index. Conclusions: Photographs from the Internet can be used to evaluate severe AGA in epidemiological studies. The prevalence of severe AGA in young Caucasian men increases with age and varies by geographical region. Body mass index is an environmental risk factor for severe AGA.

  9. Efficacy and safety of superficial cryotherapy for alopecia areata: A retrospective, comprehensive review of 353 cases over 22 years.

    Science.gov (United States)

    Jun, Myungsoo; Lee, Noo Ri; Lee, Won-Soo

    2016-10-06

    Alopecia areata (AA) affects anagen hair follicles, resulting in non-scarring hair loss. Since introduced by Huang et al., superficial cryotherapy has been accepted as a considerable primary therapeutic modality for AA. The aim of this study was to objectively clarify the therapeutic efficacy and safety of superficial hypothermic cryotherapy for treatment of AA. Medical records of 353 patients from 1993 to 2014 were retrospectively analyzed. According to the response to the superficial cryotherapy, patients were categorized into four groups: "marked", "partial", "poor" and "no recovery". The marked and partial recovery groups were considered as responders. The proportions of the responders among patient subgroups which were defined by various patients, disease, and treatment factors were compared. Of the patients, 60.9% were classified as responders after 3 months of superficial hypothermic cryotherapy. The proportion of the responders were higher when the treatment interval was 2 weeks or less and in the incipient disease stage, with statistical significance. No severe side-effects other than mild pain and pruritus were reported. In conclusion, superficial cryotherapy is an effective and safe therapeutic modality for AA. Especially when the treatment interval is 2 weeks or less and in the first occurrence of the disease, the therapeutic outcome is superior.

  10. Sterol intermediates of cholesterol biosynthesis inhibit hair growth and trigger an innate immune response in cicatricial alopecia.

    Directory of Open Access Journals (Sweden)

    Sreejith P Panicker

    Full Text Available Primary cicatricial alopecia (PCA is a group of inflammatory hair disorders that cause scarring and permanent hair loss. Previous studies have implicated PPARγ, a transcription factor that integrates lipogenic and inflammatory signals, in the pathogenesis of PCA. However, it is unknown what triggers the inflammatory response in these disorders, whether the inflammation is a primary or secondary event in disease pathogenesis, and whether the inflammatory reaction reflects an autoimmune process. In this paper, we show that the cholesterol biosynthetic pathway is impaired in the skin and hair follicles of PCA patients. Treatment of hair follicle cells with BM15766, a cholesterol biosynthesis inhibitor, or 7-dehydrocholesterol (7-DHC, a sterol precursor, stimulates the expression of pro-inflammatory chemokine genes. Painting of mouse skin with 7-DHC or BM15766 inhibits hair growth, causes follicular plugging and induces the infiltration of inflammatory cells into the interfollicular dermis. Our results demonstrate that cholesterologenic changes within hair follicle cells trigger an innate immune response that is associated with the induction of toll-like receptor (TLR and interferon (IFN gene expression, and the recruitment of macrophages that surround the hair follicles and initiate their destruction. These findings reveal a previously unsuspected role for cholesterol precursors in PCA pathogenesis and identify a novel link between sterols and inflammation that may prove transformative in the diagnosis and treatment of these disorders.

  11. Alopecia en mujeres con obesidad severa y mórbida sometidas a cirugía bariátrica Alopecia in women with severe and morbid obesity who undergo bariatric surgery

    Directory of Open Access Journals (Sweden)

    P. Rojas

    2011-08-01

    Full Text Available Introducción: La cirugía bariátrica produce una reducción de peso significativa, pero se asocia a un mayor riesgo de presentar algunas deficiencias nutricionales. Una complicación frecuente, poco estudiada, que se ha relacionado principalmente con deficiencia de zinc, es la alopecia. Objetivos: comparar el estado nutricional de zinc, hierro, cobre, selenio y proteico-visceral en mujeres con distinto grado de caída del pelo al sexto mes post bypass gástrico o gastrectomía tubular. Métodos: Según el grado de caída de pelo las pacientes fueron divididas en dos grupos: grupo 1 o caída leve (n = 42 y grupo 2 o caída importante del pelo (n = 45. Se evaluó en el preoperatorio y al sexto mes postoperatorio la ingesta de zinc, hierro, cobre y selenio, además de indicadores del estado nutricional de zinc, hierro, cobre y proteico visceral. Resultados: En ambos grupos se produjo una reducción significativa del peso al sexto mes postoperatorio (-38,9 ± 16,4%. Las pacientes del grupo1 presentaron una ingesta significativamente mayor de zinc (20,6 ± 8,1 contra 17,1 ± 7,7 mg/d y de hierro (39,7 ± 35,9 contra 23,8 ± 21,3 mg/d., y un menor compromiso del estado nutricional de zinc y hierro que el grupo 2, pero las pacientes del grupo 2 presentaron un menor compromiso del estado nutricional de cobre. No hubo diferencias en las concentraciones plasmáticas de albúmina. Conclusiones: Las pacientes que presentan una menor caída del pelo hasta el sexto mes postoperatorio tienen una mayor ingesta de zinc y hierro, y un menor compromiso del estado nutricional de ambos minerales.Introduction: Bariatric surgery leads to a significant body weigh reduction although it is associated to a higher risk of presenting some nutritional deficiencies. A common complication, little studied and mainly related to zinc deficiency is alopecia. Objectives: To compare the nutritional status of zinc, iron, copper, selenium and protein-visceral in women with different

  12. A clinical analysis of 304 cases with alopecia areata in children%儿童斑秃304例临床回顾性分析

    Institute of Scientific and Technical Information of China (English)

    刘元香; 孙玉娟; 张霞; 燕丽; 马琳; 徐子刚

    2015-01-01

    ObjectiveTo investigate clinical and laboratory tests features of 304 pediatric patients with alopecia areata in Beijing Children’s Hospital.MethodsThe retrospective study included 304 pediatric patients with alopecia areata in Beijing Children’ s hospital from 2010 to 2014. Data about the clinical characteristics were analyzed.ResultsThe male to female ratio was 1.3:1. The peak age of the ifrst visit was three to seven years old. The mean age of onset was 3.98±3.06 years. The percentage of severe alopecia areata is 61.8%, and the mean age of severe alopecia areata and mild alopecia arata was 3.50±3.24 years and 5.15±3.32 years respectively. The most common season of the onset of the disease is spring(29%). 26.8% cases with nail involvement, of which pitted nail was seen in 29 children(10%). 13.82% of the patients with allergic diseases. 98/153(64.1%) of the patients with abnormal of trace elements in peripheral blood, and the reduction of zinc and iron were the most common. CD8+T decreased in 23 cases(12.9%). ConclusionThe peak age of the disease onset was pre-school age. The younger age of onset means the more severe of hair loss and a longer course of the disease. Allergic factors can not be ignored in children with alopecia areata.%目的:分析北京儿童医院皮肤科门诊304例斑秃患儿的疾病特点。方法以304例儿童斑秃患者为研究对象,对其临床特点、实验室检查进行回顾性分析和研究。结果男女之比为1.3:1;发病年龄为(4.13±3.36)岁。39.8%的患儿就诊年龄集中在3~7岁学龄前期;重症斑秃占61.8%,其发病年龄为(3.50±3.24)岁,轻症斑秃发病年龄(5.15±3.32)岁;29%患儿春季发病;26.8%患儿并发甲改变,以点状凹陷最常见;13.82%的患儿并发过敏性疾病;98例患儿(64.1%)微量元素监测异常,以血锌、血铁降低为主;外周血CD8+T淋巴细胞下降为主。结论儿童斑秃各年龄段均可发病,以

  13. 火针配合中药治疗斑秃疗效观察%Therapeutic Observation of Fire Needling plus Chinese Herbal Medicine for Alopecia Areata

    Institute of Scientific and Technical Information of China (English)

    麻秋雷; 梁冰洁; 李鹏; 赵烨; 孟凡征; 李平

    2015-01-01

    目的:观察火针配合中药治疗斑秃的临床疗效。方法将50例斑秃患者随机分为治疗组35例和对照组15例。治疗组采用火针配合中药治疗,对照组采用单纯口服中药治疗。治疗3个月后比较两组临床疗效。结果治疗组总有效率为97.1%,对照组为73.3%,两组比较差异具有统计学意义(P<0.05)。结论火针配合中药是一种治疗斑秃的有效方法。%Objective To observe the clinical efficacy of fire needling plus Chinese herbal medicine in treating alopecia areata. Method Fifty patients with alopecia areata were randomized into a treatment group of 35 cases and a control group of 15 cases. The treatment group was intervened by fire needling plus Chinese herbal medicine, while the control group was by oral administration of Chinese herbal medicine alone. The clinical efficacies were compared after 3-month treatment.Result The total effective rate was 97.1% in the treatment group versus 73.3% in the control group, and the difference was statistically significant (P<0.05).Conclusion Fire needling plus Chinese herbal medicine is an effective method in treating alopecia areata.

  14. Alopecia Areata Patients with Nail Lesions%斑秃患者合并甲病变及中医证型分析

    Institute of Scientific and Technical Information of China (English)

    李雪; 朱培成

    2012-01-01

    目的 探讨斑秃患者伴甲病变情况.方法 回顾分析2010年3月-11月所收集的197例斑秃患者病史资料.结果 合并甲病变者有70例,甲病变率为35.5%,其甲病变率较高的分别是重症斑秃(59.2%)、全秃(75.0%)、普秃(64.0%),而甲病变类型又以甲纵嵴、甲凹点及糙甲最为常见.结论 斑秃患者一旦出现甲损害可能是一种预后不良的指征.伴甲病变的斑秃患者的中医证型以肝肾不足型、气血两虚型最常见.%Objective To investigate patients with nail lesions of alopecia areata (AA). Methods 197 cases of AA patients, medical history information which were collected from March 2010 to November 2010 were reviewed. Results AA lesions in patients with a combined total of 70 cases, accounting for 35.5%. Common in alopecia totalis (75.0%), general bald (64.0%), severe alopecia areata (59.2%), the lesion to a longitudinal ridge, a hollow point and a rough-based. Conclusion We believe that AA patients with nail lesions may be an indicator of poor prognosis. We also find that liver and kidney deficiencies and deficiency of both qi and blood were the main syndromes types.

  15. General situation of TCM research in on sebrrheic alopecia%脂溢性脱发的中医研究概况

    Institute of Scientific and Technical Information of China (English)

    马倩; 王学岭

    2016-01-01

    Seborrheic alopecia is a common and frequently encountered disease in department of dermatology, it is also one of the refractory diseases. Its pathogenesis remains unclear in western medicine. Most modern TCM doctors hold that the pathogenesis of alopecia is related to three aspects: The Yin deficiency of liver and kidneys mingled with damp-heat or stasis toxin, the deficiency of Lung Qi and lung yin and the intermingled deficiency and excess, which engenders phlegm stagnation, caused by mental stress and improper diet. There are many methods of TCM clinical treatment on seborrheic alopecia, such as syndrome differentiation, prescriptions from classics of TCM or doctors’ experience, combination of TCM and western medicine, combination of internal and external treatment, which has achieved some progresses, however, it is undeniable that there are also some existing problems.%脂溢性脱发是皮肤科常见病、多发病,也是难治性疾病之一。西医对本病病因尚不清楚,现代多数中医学者认为脱发发病多与三个方面相关:肝肾阴虚与湿热或瘀毒夹杂、肺气与肺阴亏虚、精神紧张与饮食失衡导致虚实夹杂,并生痰瘀。中医临床治疗该病有多种方法,如分证论治、单方验方、中西药结合、内外合治,已经取得一定进展,但仍存在一些问题。

  16. HPLC法测定斑秃搽剂中米诺地尔含量%Determination of minoxidil content in liniment for alopecia areata by HPLC method

    Institute of Scientific and Technical Information of China (English)

    赵瑛; 谢军; 廖海燕

    2013-01-01

    Objective To establish the method for the detection of minoxidil content in alopecia areata liniment by HPLC. Methods The content of minoxidil in three batches of alopecia areata liniment supplied by a hospital were detected by SHMADZU VP - ODS chromatographic column with the mobile phase of methanol - water( 72:28 ),the detecting wavelength of 230 nm,and the column temperature of 35 °C . Results The linear equation of minoxidil reference substance was Y = 153. 31X -42. 33l( n = 6 ),r = 0. 9999. The sample average recovery rate was 101. 94% and RSD was 0. 6% ( n = 6 ). The precision was good, and RSD was 0. 9% ( n =5 ). Conclusion The method of HPLC can accurately detect the content of minoxidil in alopecia areata liniment,which can be used as the method for the quality control of this liniment.%目的 应用HPLC法建立斑秃搽剂中米诺地尔含量测定方法.方法对某医院提供的3批次斑秃搽剂,检测其中米诺地尔的含量.采用SHMADZU VP - ODS色谱柱,流动相:甲醇-水(72∶28),检测波长230 nm,柱温35 ℃.结果 米诺地尔对照品线性方程式为Y=153.37X-42.331(n=6),r=0.9999;样品平均回收率为101.94%,RSD=0.6%(n=6);精密度良好,RSD=0.9%(n=5).结论 HPLC法能准确测定出斑秃搽剂中米诺地尔含量,可作为该制剂的质量控制检测方法.

  17. 康复新液治疗斑秃的临床疗效观察%Clinical Observation of Rehabilitation New Liquid Treatment for Alopecia Areata

    Institute of Scientific and Technical Information of China (English)

    海日古力·克比尔

    2013-01-01

    目的:观察康复新液外搽治疗斑秃的临床疗效。方法将60例斑秃患者随机分成治疗组和对照组各30例。治疗组给予康复新液外搽患处,3次/d;对照组给予自制复方生发酊外搽患处,3次/d。30d后对比两组临床疗效。结果治疗组有效率80.0%,对照组有效率53.3%,两组有效率比较有统计学意义(P<0.05)。结论康复新液外搽治疗斑秃效果优于外搽自制复方生发酊患者。%Objective To observe the ef icacy of the alopecia areata topical treated by KangFuXinYe. Methods There are 60 alopecia areata patients which were devided in average into 2 groups:the control group and treatment group. The patients in treatment group use KangFuXinYe three times a day on the surface of the skin,while the control group use homemade compound germinal tincture three tinmes a day. Comparing the ef icacy of the two groups 30 days later. Results The ef icient of treatment group is 80%,while the control group is 53.3%,there was a significant dif erence. (P<0.05) Conclusion The ef icacy of KangFuXinYe topical treated on alopecia areata is bet er than homemade compound germinal tincture.

  18. Effects on Nursing Intervention for the Treatment of Seborrheic Alopecia%护理干预对脂溢性脱发治疗的影晌

    Institute of Scientific and Technical Information of China (English)

    邝瑞明; 黄春容

    2011-01-01

    目的:探讨护理干预对脂溢性脱发治疗的影响.方法:将80例脂溢性脱发患者随机分为2组.常规组(31例)予自拟脱发方治疗,干预组(49例)在脱发方治疗的基础上对患者的心理、饮食和生活进行护理干预,观察2组疗效的差异性.结果:干预组的治疗效果优于常规组(P<0.01).结论:护理干预对脂溢性脱发的治疗有着积极的作用,能够提高脂溢性脱发的疗效.%Objective:To explore the effects on nursing intervention for the treatment of seborrheic alopecia. Method:80 patients with seborrheic alopecia were randomly divided into 2 groups.Conventional group (31 cases) received self-made TuoFaFang of TCM. Intervention group (49 cases) received the nursing intervention of psychology, dietary and life on the basis of self-made TuoFaFang.The treatment differences were observed. ResultThe therapeutic effect in the intervention group is better than in the conventional treatment group (P<0.01).Conclusion:Nursing intervention had a positive effect and can improve treatment outcome for the treatment of seborrheic alopecia.

  19. Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population*

    Science.gov (United States)

    Barbosa, Ângela Marques; Prestes-Carneiro, Luiz Euribel; Sobral, Aldri Roberta Sodoschi; Sakiyama, Marcelo Jun; Lemos, Bruna Cerávolo; de Abreu, Marilda Aparecida Milanez Morgado; Martos, Luciana Leite Crivelin; Moliterno, Ricardo Alberto

    2016-01-01

    Background Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic. Studies linking Human Leukocyte Antigens (HLA) to AA have suggested that immunogenetic factors may play a role in the disease's onset/development. Objectives To investigate an association between AA and HLA class I/II in white Brazilians. Methods: Patients and control groups comprised 33 and 112 individuals, respectively. DNA extraction was performed by column method with BioPur kit. Allele's classification was undertaken using the PCR-SSO technique. HLA frequencies were obtained through direct counting and subjected to comparison by means of the chi-square test. Results Most patients were aged over 16, with no familial history, and developed partial AA, with no recurrent episodes. Patients showed a higher frequency of HLA-B*40, HLA-B*45, HLA-B*53 and HLA-C*04 compared with controls, although P was not significant after Bonferroni correction. Regarding HLA class II, only HLA-DRB1*07 revealed statistical significance; nevertheless, it featured more prominently in controls than patients (P=0.04; Pc=0.52; OR=0.29; 95%; CI=0.07 to 1.25). P was not significant after Bonferroni correction. Conclusions The development of AA does not seem to be associated with HLA in white Brazilians, nor with susceptibility or resistance. The studies were carried out in populations with little or no miscegenation, unlike the Brazilian population in general, which could explain the inconsistency found. PMID:27438193

  20. New Ideas of Alopecia Areata Pathogenesis and Treatment%斑秃发病机制研究和治疗的新理念

    Institute of Scientific and Technical Information of China (English)

    章星琪

    2010-01-01

    @@ 斑秃(Alopecia areata, AA)是一种非瘢痕性的炎症性脱发性疾病,常见的临床表现是头部出现边界清晰的圆形斑状脱发,大约半数病人病情反复发作,可迁延数年或数十年[1].少数病人病情严重,毛发脱落可累及整个头部的终毛(全秃),甚至累及全身的毳毛脱落(普秃)[2-3].

  1. Clinical study of androgenic alopecia in 148 patients%男性型脱发148例临床分析

    Institute of Scientific and Technical Information of China (English)

    谭凤明; 侯显曾; 张滨岳; 姚海峰; 程喜平

    2012-01-01

    目的 探讨男性型脱发的临床特征.方法 收集148例男性型脱发病例的临床资料,并对患者的发病年龄、家族史、临床分级、疗效、血清双氢睾酮(DHT)、轻拉试验进行分析.结果 发病年龄以 15~25岁占比例最大,家族史与发病年龄相关,家族史与临床分级相关,血清DHT水平升高占80.41%,非那雄胺治疗总有效率为88.98%,轻拉试验阳性占22.97%.结论 男性型脱发发病年龄偏早,发病与职业、精神神经因素有关,有家族史患者的发病年龄比无家族史患者的发病年龄更早,有家族史患者出现重型男性型脱发的可能性更大,疗效与疗程呈正相关,疗效与家族史无关,部分患者出现轻拉试验阳性.%Objective To investigate the clinical characteristics of androgenic alopecia. Methods The clinical information of 148 cases of androgenic alopecia during the last three years was collected. The age of onset, family history, clinical classification, therapeutic efficacy, plasma dihydrotestosterone ( DHT ), light hair - pull test of the patients were analyzed. Results Most diseases got onset at the age between 15 and 25. Significant correlations were revealed between the family history and onset age or clinical classification ( P <0. 05 ). Elevated DHT was also revealed in 80. 41% patients. The overall effective rate of fiansteride treatment and positive light hair-pull rates were 88. 98% and 22. 97% , respectively. Conclusion The onset age of androgenic alopecia is young. And it is correlated with occupational and psychiatric factors. Patients with family history suffer earlier onset age and higher probability of severe androgenic alopecia. However, the efficacy of treatment is correlated with the course of therapy but not with family history.

  2. 雄激素源性脱发的中医治疗进展%TCM Treatment Developments to Androgenetic Alopecia(AGA)

    Institute of Scientific and Technical Information of China (English)

    任芳; 魏跃钢

    2012-01-01

    AGA is the most common alopecia in clinic, showing gradual alopecia with thinner hairs on forehead and front top of the head, then to the top head, belonging to the androgen-depending autosome dominant heredity polytrope disease. TCM has advantages on it. The article sums up the treatment of the disease in recent years on therapy based on differentiation, special formula, outer therapy and acupuncture, etc.%雄激素源性脱发是临床上最常见的脱发类型,表现为前额及前顶部的毛发稀疏变细的渐进性脱发,继而形成高额,为雄激素依赖的常染色体显性遗传性多变性疾病,中医药治疗有明显的优势.本文分别从其辩证论治、经验专方、外治法、针灸疗法等方面就近年来的治疗进展加以综述.

  3. Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques.

    Science.gov (United States)

    Pan, H J; Wilding, G; Uno, H; Inui, S; Goldsmith, L; Messing, E; Chang, C

    1998-08-01

    The effect of androgen receptor transcriptional activation by RU58841, a nonsteroidal anti-androgen, was studied in the human prostate cancer PC3 cell line by cotransfection with wild-type androgen receptor (wt AR) and an androgen-responsive reporter (MMTV-ARE-CAT) construct. Anti-and rogens, hydroxyflutamide, and Casodex, and the antiestrogen, genistein, were studied in parallel for comparison with RU58841. The wt AR was activated only by the androgen dihydrotestosterone (DHT). Neither the anti-androgens nor antiestrogen can enhance AR transcriptional activity at 10(-11)-10(-7)M in PC3 cells. Hydroxyflutamide, RU58841, and Casodex, but not genistein, displayed competitively suppressive effects on DHT activation of wt AR. The potency of RU58841 was comparable to that of hydroxyflutamide. From this result, topical application of RU58841, which is considered to be a potential therapy for skin diseases, may induce systemic side effects. However, RU58841, on topical application, revealed a potent increase in density, thickening, and length of hair in the macaque model of androgenetic alopecia, whereas no systemic effects were detected. Together our results suggest that RU58841 may have potent antagonism to the wt AR and could be considered as a topically applied active anti-androgen for the treatment of androgen-dependent skin disorders, such as acne, androgenetic alopecia, and hirsutism.

  4. Coat condition of ringtailed lemurs, Lemur catta, at Berenty Reserve, Madagascar: II. Coat and tail alopecia associated with Leucaena leucocepahala, 2001-2006.

    Science.gov (United States)

    Jolly, Alison

    2009-03-01

    Fur condition in wild ringtailed lemurs, Lemur catta, was recorded during September-November birth seasons 2001-2006 at Berenty Reserve, Madagascar. Body coat condition was scored on a scale from BS 0: full, smooth coat with guard hairs, to BS5: half or more of back and limbs hairless. Tail condition was scored from TS 0: full, to TS 5: half or more hairless. Where troop core areas included stands of Leucaena leucocephala, alopecia was dramatically more frequent than in similar areas without leucaena, including many animals with score BS5 or TS5, "bald lemur syndrome." Females' coats were worse than males', possibly related to female dominance and access to this preferred food. Tails in non-leucaena-feeding females tend to remain full, even if coats deteriorate, but with leucaena-feeding female tails are highly correlated with coat condition and equally bare. Coat and tail condition in L. catta reflected not only the dietary toxin but individual differences as well as differences between adjacent troops that may result from territorially mediated access to the environment. Leucaena contains the non-protein amino acid mimosine, a known cause of alopecia, wasting, and organ damage in livestock, although the effects are usually reversible. This is the first case of its effect in wildlife. Leucaena is an agroforestry tree introduced throughout the tropics. In high dietary concentrations leucaena might potentially affect any browsing mammal.

  5. Alopecia areata por uso de leflunomida en una paciente con artritis reumatoide: reporte de caso y revisión de literatura

    Directory of Open Access Journals (Sweden)

    María Ignacia Molina Molina

    2016-03-01

    Full Text Available La artritis reumatoide es una enfermedad de tipo autoinmune. Por su carácter altamente invalidante, requiere de manejo farmacológico agresivo. Para ello, habitualmente se hace necesario el uso de drogas inmunomoduladoras agrupadas bajo el nombre de fármacos antirreumáticos modificadores de la enfermedad. Uno de los utilizados con mayor frecuencia es la leflunomida, la cual por su mecanismo de acción es capaz de suprimir ejes fundamentales en el proceso de la enfermedad. Sin embargo, su uso no se encuentra exento de efectos secundarios. Si bien existen series que reportan que los efectos adversos más prevalentes son diarrea, náuseas, exantema y alopecia, existen escasos reportes de casos de alopecia areata universal secundaria al uso de leflunomida. A propósito de un caso en el Hospital Regional de Talca, se realizó una revisión de la literatura acerca del tema.

  6. Pharmacological inhibition of DGAT1 induces sebaceous gland atrophy in mouse and dog skin while overt alopecia is restricted to the mouse.

    Science.gov (United States)

    Floettmann, Eike; Lees, David; Seeliger, Frank; Jones, Huw Bowen

    2015-04-01

    Diacylglycerol O-acyltransferase 1 (DGAT1) plays an important role in synthesizing lipids, and inhibitors of DGAT1 have been investigated as potential treatments for diabetes and metabolic diseases. DGAT1 knockout (-/-) mice are resistant to obesity, have increased sensitivity to insulin, and exhibit sebaceous gland atrophy and alopecia. Prolonged pharmacological inhibition of DGAT1 with AZD7687 in mice results in the same skin phenotype, including sebaceous gland atrophy and alopecia, as seen in the skin of DGAT1 (-/-) mice. AZD7687-mediated effects on the skin were dose- and time-dependent and reversible. They occurred only at substantial levels of continuous DGAT1 inhibition. Prolonged treatment of dogs with AZD7687 also resulted in sebaceous gland atrophy but did not result in the more adverse skin changes of hair loss and skin lesions. Our findings highlight a significant risk of generating the same lesions that were seen in mouse skin during clinical development of DGAT1 inhibitors in humans and also reveal a species difference in the effects on the skin, indicating that the mouse may be an especially sensitive species. Therefore, although human therapeutic doses may not have the same influence on skin morphology as seen in mice, monitoring of skin changes will be essential in clinical trials with DGAT1 inhibitors.

  7. 家族史对雄激素性秃发患者发病年龄和脱发类型的影响%Analysis the Differences of Onset Age and Hair Loss Types in Patients with Androgenetic Alopecia with or without Family History

    Institute of Scientific and Technical Information of China (English)

    罗丽芳; 王霞; 李凌; 杨阁; 叶倩如; 卢肖霞; 熊春萍

    2013-01-01

    目的分析有无家族史雄激素性秃发( AGA)患者发病年龄、脱发类型及脱发程度的异同。方法采用问卷调查方式对976例有家族史的雄激素性秃发患者和690例无家族史该病患者进行调查。结果有家族史雄激素性秃发患者与无家族史该病患者比较,发病年龄早(P<0.01),男性患者前额型发病频率低(P=0.044),脱发程度严重( P=0.020)。结论雄激素性秃发发病年龄、脱发类型和严重程度与家族史密切相关。%Objective To analysis the differences of onset age , alopecia type and alopecia level between androgenetic alopecia patients with or without family history .Methods A questionnaire investigation was con-ducted to investigate 976 androgenetic alopecia patients with family history and 690 androgenetic alopecia pa-tients without family history .Results Androgenetic alopecia patients with family history had an more earlier on-set (P<0.01), lower frequency of forehead hair loss in male (P=0.044) and more serious pattern(P=0. 020 ) compared to patients without family history .Conclusion The onset age , alopecia type and alopecia level of androgenetic alopecia are closely related with family history .

  8. Analysis report of bio-resonance technique adaptability screening of natural plant essential oil for alopecia areata%斑秃患者对27种植物精油适应性检测结果分析

    Institute of Scientific and Technical Information of China (English)

    陈正琴; 潘钰蔚; 刘倩; 张怀亮

    2012-01-01

    Objective To find the most adaptive natural plant essential oil for alopecia areata patients. Methods Meridian bio-resonance technique was adopted to screening adapted essential oil for alopecia areata patients through meridian points with MED Model, and control with standard samples. Results The adaptation percentage of 27 kind natural plant essential oil to 33 alopecia areata patients is 9.09%~27.27%, average 16.56%. Each kind of the essential oil had its corresponding adaptive patients. The top ten showed a good adaptability were sage, clove, fennel, lemon, fragrant cananga, tea plant, basil,rose,eucalyptus, angerine. Conclusion The detection with meridian bio-resonance technique screening 33 alopecia areata patients through meridian points with MED Model showed that some kinds of the natural plant essential oil have good adaptability to alopecia areata patients.%目的 寻找适宜于斑秃患者的最佳植物精油品种.方法 27种植物精油纯品,采用生物共振技术,对33例斑秃患者进行检测,统计适应性.结果27种植物精油对33例斑秃的适应百分率为9.09%~27.27%,平均为16.56%.所有的植物精油均有适应的患者,排列在前10位的植物精油分别是:鼠尾草、丁香、茴香、柠檬、依兰、茶树、罗勒、玫瑰、尤加利、红桔.结论 斑秃患者对部分植物精油的适应性较好.

  9. A Retrospective Analysis of Clinical Feature of Dermoscopy in 96 Cases with Alopecia Areata%96例斑秃皮肤镜临床表现分析

    Institute of Scientific and Technical Information of China (English)

    庄娘桥; 唐旭华; 李俊珊; 曹孙香; 章星琪

    2015-01-01

    Objective:To analyze dermoscopic findings of alopecia areata ( AA) that can be used as clinical indicators of disease diagnosis.Methods:The dermoscopic findings in 96 newly diagnosed AA patients and dermoscopic examination of areas of hair loss on the scalp were collect-ed.Results:Characteristic dermoscopic findings of AA included yellow dots, black dots, broken hairs, exclamation mark sample hair, and clustered short vellus hairs ( shorter than 10 mm) .The highest incidence appears in yellow dots which up to 69.8%,and can be regarded as a sensitive indicator in the diagnosis of alopecia areate.Exclamation mark sample hair(40.6%) , black dots (52.1%), broken hairs(48.9%) all were highest in the active phase, which were important sigh of alopecia areata.Conclusion:Dermoscopic signs are highly useful in diagnosis, evaluation for activity and therapeutic effect of AA.%目的:探讨皮肤镜下斑秃临床特征表现. 方法:分析2013 年12 月至2014 年11 月我科门诊确诊为斑秃的96例患者的临床资料、皮肤镜特征. 结果:斑秃患者脱发区域皮肤镜征象包括黄点征、黑点征、断发、感叹号样发、短毳毛(新生短发<10 mm). 其中黄点征发生率最高,达69.8%,是诊断斑秃的敏感指标;感叹号样发、黑点征、断发在活动期发生率高,分别是40.6%、52.1%、48.9%,是斑秃重要的皮肤镜征象. 结论:上述皮肤镜征象在斑秃的诊断、活动性评判及疗效评估上有较高的应用价值.

  10. DEVELOPMENT OF ALOPECIA DURING TREATMENT WITH A TUMOR NECROSIS FACTOR-ALPHA INHIBITOR IN A FEMALE PATIENT WITH PSORIATIC ARTHRITS: A CLINICAL CASE

    Directory of Open Access Journals (Sweden)

    R. G. Mukhina

    2016-01-01

    Full Text Available Objective: to describe a case of the total development of alopecia in a female patient with psoriatic arthritis during treatment with a tumor necrosis factor-αlpha (TNF-α inhibitor. Materials and methods. Patient I., aged 36 years has been followed up at the Kazan’ Center of Rheumatic Diseases and Osteoporosis since 1998. At approximately the same time, the patient noted the appearance of skin eruptions behind the ears, on the skin of the scalp. She was examined by a dermatologist who diagnosed psoriasis. In 2005, she was admitted to Kazan’ Rheumatology Center, City Clinical Hospital Seven, for the development of obvious synovitis of the knee joint and for the inefficiency of therapy with nonsteroidal anti-inflammatory drugs and diagnosed with psoriatic arthritis. During the prescribed therapy with methotrexate 10 mg/week, evident menstrual irregularities were observed in the patient who stopped using the drug herself. The second pregnancy occurred in 2008. Articular syndrome progression and eruptive psoriasis were recorded in the lactation period. After lactation cessation in 2009, she was hospitalized again. Her examination revealed high laboratory activity (erythrocyte sedimentation rate, as high as 40 mm/hr; magnetic resonance imaging of the knee joints showed the signs of bilateral synovitis; lumbar spine radiography exhibited grade II sacroiliitis. Leflunomide 20 mg/day was recommended as a basic drug. In 2012, the patient used leflunomide, her condition worsened; joint pain progressed; new joints were involved into the process, and cutaneous manifestations were aggravated. To verify a diagnosis and to choose therapy, the patient was referred to a consultation at the Moscow Research Institute of Rheumatology. Results. In connection with the high activity of the disease and with no response to the performed therapy, it was recommended to initiate therapy with biologics, such as infliximab, the drug of choice. Seven infliximab

  11. National Alopecia Areata Foundation

    Science.gov (United States)

    ... checkout and they’ll donate 10% of your purchase to NAAF. START SHOPPING Homepage 3 Column Row Follow us Created with Sketch. Youtube Facebook image/svg+xml Twitter What’s happening in your ...

  12. Cicatricial Alopecia Overview

    Science.gov (United States)

    ... evaluation of the hair bulbs—expansions at the base of the hair from which the shaft develops— ... may result from changes in the lipid and metabolism in the oil glands. Specifically, the loss of ...

  13. Hair Loss (Alopecia)

    Science.gov (United States)

    ... for public Dermatology World Dialogues in Dermatology JAAD Mohs AUC MyDermPath+ Psoriasis Patient education resources Practice Management ... on the top of the scalp. The U.S. Food and Drug Administration (FDA) has approved minoxidil to ...

  14. Hair Loss (Alopecia)

    Science.gov (United States)

    ... Genitals and Urinary Tract Glands & Growth Head Neck & Nervous System Heart Infections Learning Disabilities Obesity Orthopedic Prevention Sexually Transmitted Skin Tobacco Treatments Injuries & ...

  15. Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study

    Directory of Open Access Journals (Sweden)

    Sakr FM

    2013-05-01

    Full Text Available Farouk M Sakr,1 Ali MI Gado,2 Haseebur R Mohammed,2 Abdel Nasser Ismail Adam3 1Department of Pharmaceutics, 2Departments of Pharmacology and Pharmaceutical Chemistry, 3Department of Biology, College of Pharmacy, Riyadh Colleges of Dentistry and Pharmacy, Riyadh, Kingdom of Saudi Arabia Background: The variable success of topical minoxidil in the treatment of androgenic alopecia has led to the hypothesis that other pathways could mediate this form of hair loss, including infection and/or microinflammation of the hair follicles. In this study, we prepared a multimodal microemulsion comprising minoxidil (a dihydrotestosterone antagonist, diclofenac (a nonsteroidal anti-inflammatory agent, and tea tree oil (an anti-infective agent. We investigated the stability and physicochemical properties of this formulation, and its therapeutic efficacy compared with a formulation containing minoxidil alone in the treatment of androgenic alopecia. Methods: We developed a multimodal oil/water (o/w microemulsion, a formulation containing minoxidil alone, and another containing vehicle. A three-phase diagram was constructed to obtain the optimal concentrations of the selected oil, surfactant, and cosurfactant. Thirty-two men aged 18–30 years were randomized to apply 1 mL of microemulsion containing the multimodal formulation (formulation A, n = 11, minoxidil alone (formulation B, n = 11 or placebo (formulation C, n = 10 twice daily to the affected area for 32 weeks. Efficacy was evaluated by mean hair count, thickness, and weight on the targeted area of the scalp. Global photographs were taken, changes in the area of scalp coverage were assessed by patients and external investigators, and the benefits and safety of the study medications were evaluated. The physical stability of formula A was examined after a shelf storage period of 24 months. Results: Formulation A achieved a significantly superior response than formulations B and C in terms of mean hair count (P

  16. Progress in molecular genetics of hereditary alopecia/hypotrichosis%遗传性秃发/少毛症分子遗传学研究进展

    Institute of Scientific and Technical Information of China (English)

    刘灵花; 汪静文; 王培光; 杨森

    2012-01-01

    Hereditary alopecia/hypotrichosis is a large group of rare genetic disorders characterized by hair loss.Many causative genes and their corresponding chromosomal locations have been identified for several types of hereditary alopecia/hypotrichosis in recent years,including Marie-Unna hereditary hypotrichosis(U2HR,8p21.3),autosomal dominant hypotrichosis simplex(APCDD1,18p11.22;RPL21,13q12),autosomal recessive hypotrichosis simplex(DSG4,18q12.1;DSC3,18q21.1;LIPH,3q26-27;P2RY5,13q13-14;10q11.23-22,3;7p21.3-p22.3),autosomal recessive woolly hair/hypotrichosis(LIPH,3q26-27;P2RY5,13q13-14),autosomal dominant woolly hair/hypotrichosis(KRT74,12q12-14)and ichthyosis follicularis-alopecia-photophobia syndrome(MBTPS2,Xp22).These genes play critical roles in the regulation of hair follicle morphogenesis and growth cycles,and their pathogenic mutations may lead to abnormality in hair follicle morphogenesis and development,thus result in alopecia/hypotrichosis.%遗传性秃发/少毛症是一组临床少见的遗传性脱发性疾病.近年确定多种遗传性秃发/少毛症的致病基因及其染色体定位,包括Marie-Urna型遗传性少毛症(U2HR,8p21.3)、常染色体显性遗传性单纯性少毛症(APCDD1,18p11.22;RPL21,13q12)、常染色体隐性遗传性单纯性少毛症(DSG4,18q12.1;DSC3,18q21.1;LIPH,3q26-27;P2RY5,13q13-14;10q11.23-22.3;7p21.3-22.3)、常染色体隐性遗传性羊毛状发(LIPH,3q26-27;P2RY5,13q13-14)、常染色体显性遗传性羊毛状发(KRT74,12q12-14)和毛囊性鱼鳞病-秃发-畏光综合征(MBTPS2,Xp22).这些基因在毛囊发生和毛囊生长周期过程中具有重要的调控作用,各种致病性突变均可导致毛囊发生和生长异常,引起秃发/少毛症.

  17. Topical or systemic 16,16 dm prostaglandin E sub 2 or WR-2721 (WR-1065) protects mice from alopecia after fractionated irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Geng, L.; Malkinson, F.D. (Rush-Presbyterian-St. Luke' s Medical Center, Chicago, IL (United States)); Hanson, W.R. (Hines VA Medical Center, IL (United States))

    1992-04-01

    Previous studies in mice demonstrated that systemic or topical 16,16 dm PGE{sub 2} protected against single dose radiation-induced hair loss. The authors have now investigated prostaglandin, or WR-2721, protection against murine alopecia produced by varying doses and schedules of fractionated radiation. In some studies with the radioprotectors given systematically, WR-2721 afforded slightly greater radioprotection than 16,16 dm PGE{sub 2}. The two compounds were essentially equally radioprotective in the topical application studies. Since both systemic and topical applications of the agents tested enhanced hair regrowth following radiation, the authors conclude that clinical use of these compounds may provide some protection of hair follicles, and perhaps other tissues, lying within a radiation therapy field. (author).

  18. Androgenetic alopecia treated with finasteride (a review)%保法止(非那雄胺)治疗雄激素性脱发

    Institute of Scientific and Technical Information of China (English)

    虞瑞尧; 薛文昌

    2001-01-01

    @@ 良性前列腺肥大(BPH)是老年人中常见、多发病.默克公司(Merck & Co,Inc)研制、生产口服5α-还原酶抑制剂非那雄胺(finasteride),商品名保列治(proscar).每片5mg,连续服用1年至2年BPH可以逐渐缩小,使病人排尿畅通.在治疗过程中病人发现秃顶的头皮上又有毛发生长出来.默克公司确信口服非那雄胺对治疗男性的雄激素性脱发(androgenetic alopecia,AGA)也称男性型脱发(male parttern hair loss,MPHL)有效.

  19. 成人斑秃与甲状腺自身免疫的关系分析%Association analysis between alopecia areata and thyroid autoimmunity in adults

    Institute of Scientific and Technical Information of China (English)

    杨竹生; 杨秀敏; 金星姬; 李娅娣; 周晓谦

    2015-01-01

    目的 评估成人斑秃患者甲状腺功能异常及甲状腺自身抗体的发生率,分析成人斑秃与甲状腺自身免疫的关系.方法 按照预先设计的调查表收集斑秃患者人口学信息、病史、斑秃一级亲属家族史,并检测甲状腺功能和甲状腺过氧化物酶抗体(TPO-Ab).结果 共有209例患者入选,6.7%的患者伴发甲状腺疾病,20.6%的患者TPO-Ab阳性.与TPO-Ab阴性的患者比较,TPO-Ab阳性的患者斑秃首次发病年龄<18岁(P=0.025)、发生全秃和(或)普秃(AT/AU)的概率更大(P=0.006)、合并甲状腺疾病的概率更大(P=0.002)、有更多的一级直系亲属成员患有斑秃(P=0.001).结论 斑秃患者TPO-Ab阳性率较高,即使无甲状腺受累的临床表现,也需对斑秃患者进行甲状腺功能及甲状腺自身抗体检测.%Objective To estimate the prevalence of thyroid dysfunction and thyroid autoantibodies in adults with alopecia areata (AA), and to analyze the relationship between alopecia areata (AA) and thyroid autoimmunity in adults.Methods A predesigned questionnaire was used to collect data on demographic information, medical history,and family history of AA in first-degree relatives from patients with AA.Thyroid function was evaluated, and anti-thyroid peroxidase antibody (TPO-Ab) was screened in all the patieuts.Statistical analysis was carried out by the chi-square test and Fisher's exact test.Results Totally, 209 patients with AA were enrolled.Of these patients, 6.7% were complicated by thyroid diseases, 20.6% were positive for TPO-Ab.Compared with the patients without TPO-Ab, those with TPO-Ab showed a significant increase in the proportion of patients with early-onset (< 18 years) AA (x2 =5.589, P =0.025),prevalence rate of alopecia totalis/alopecia universalis (x2 =9.990, P=0.006) and thyroid diseases (x2 =12.279, P =0.002), and incidence rate of AA in first-degree relatives (x2 =14.426, P =0.001).Conclusions The positive rate of TPO-Ab is

  20. Mandibulofacial dysostosis, severe lower eyelid coloboma, cleft palate, and alopecia: A new distinct form of mandibulofacial dysostosis or a severe form of Johnson-McMillin syndrome?

    Science.gov (United States)

    Zechi-Ceide, Roseli Maria; Guion-Almeida, Maria Leine; Jehee, Fernanda Sarquis; Rocha, Katia; Passos-Bueno, Maria Rita Santos

    2010-07-01

    We describe a patient with a phenotype characterized by mandibulofacial dysostosis with severe lower eyelid coloboma, cleft palate, abnormal ears, alopecia, delayed eruption and crowded teeth, and sensorioneural hearing loss. The karyotype and the screening for mutations in the coding region of TCOF1 gene were normal. The clinical signs of our case overlap the new mandibulofacial dysostosis described by Stevenson et al. [2007] and the case with Johnson-McMillin syndrome described by Cushman et al. [2005]. The similar clinical signs, mainly, the severe facial involvement observed in these cases suggest that they can represent a new distinct form of mandibulofacial dysostosis or the end of the spectrum of Johnson-McMillin syndrome.

  1. The Pathogenesis of a Androgenetic Alopecia and Laser Therapy%雄激素性脱发的发病机制与激光治疗

    Institute of Scientific and Technical Information of China (English)

    李盛; 黄茜; 陈敏

    2016-01-01

    雄激素性脱发(androgenetic alopecia,AGA)是皮肤科的常见病与多发病,雄激素性脱发的药物综合治疗及手术治疗的部分患者取得了一定的效果,但都存在副作用大、患者依从性差等问题,有研究表明低功率激光能够促进动物毛发的生长,因而可能在改善雄激素性脱发的症状方面具有重要的应用前景。本文回顾近年来对雄激素性脱发的可能发病机制、治疗现状及激光治疗的研究情况和进展,旨在为雄激素性脱发的治疗奠定科学依据。%Androgenetic alopecia is a common and frequently-occurring disease in dermatology.It has a positive effects on some patients by the medical comprehensive treatment and surgical treatment.However,it has a negative effect on some other patients because it has a poor treatment compliance.Studies have shown that low power laser could promote the growth of animal hair,which may have crucial application perspective.The purpose of this paper is to review the studies of the progress of possible reasons and treatments on androgenetic alopecia and the progress of laser therapy in re-cent years,and to have a further study based on these.

  2. 毛囊干细胞在盘状红斑狼疮性脱发和斑秃中的变化及意义%The changes of hair follicle stem cells in alopecia caused by discoid lupus erythematosus and alopecia areata and their signiifcance

    Institute of Scientific and Technical Information of China (English)

    管海宏; 李泓馨; 林麟

    2013-01-01

    目的了解毛囊干细胞在常见瘢痕性脱发和非瘢痕性脱发中的变化及意义。方法采用SP免疫组化法检测毛囊干细胞常用标志分子CK15、CD200在常见瘢痕性脱发和非瘢痕性脱发即盘状红斑狼疮(DLE)和斑秃皮损中的表达。每组8例患者,以同等数量正常人头皮做对照。结果毛囊干细胞标志CK15、CD200在正常对照的阳性率均为100%,而在DLE患者头皮中的阳性率分别为37.5%和12.5%,同正常对照相比均明显减少(P<0.05);斑秃患者毛囊中CK15阳性表达率为100%,CD200阳性表达率为50%,CD200阳性表达率与正常对照相比明显减少(P<0.05)。结论毛囊干细胞在DLE患者中明显受损,可能与其永久性脱发有关;而在斑秃中毛囊干细胞无减少。CD200在毛囊表达减少可能与斑秃及DLE的发病相关。%Objective To investigate the changes of hair follicle stem cells and their signiifcance in the common scaring alopecia and non-scaring alopecia caused by discoid lupus erythematosus (DLE) and alopecia areata (AA). Methods Immunohistochemical method was performed to detect CK15 (cytokeratin 15) and CD200, two markers of hair follicle stem cells, in the alopecia lesions of 16 patients with DLE(8 cases) or AA(8 cases). Samples from healthy people after plastic surgery were as the controls. Results The positive expression of CK15 and CD200 in the follicles of DLE lesions was 37.5%and 12.5%respectively, signiifcantly diminished compared with that in healthy controls (both are 100%, P<0.05). The positive expression of CK15 in follicles of AA lesions was normal, while the positive expression of CD200 was 50%, signiifcantly diminished compared with that in healthy controls (P<0.05). Conclusion Hair follicle stem cells were signiifcantly damaged in scarring alopecia caused by DLE but not AA, meanwhile the expression of CD200 decreased in follicles of patients with AA. The damage of hair follicle stem cells may

  3. 补肝肾增发灵粉剂胶囊治疗肝肾不足型脱发的临床疗效观察%Clinical observation on treating alopecia with the Zengfa Ling capsule

    Institute of Scientific and Technical Information of China (English)

    陈本善

    2014-01-01

    To investigate clinical effects of Zengfa Ling capsule on alopecia. Methods:191 patients were given Zengfa Ling capsule for 3 months. Results:188 patients were better, while 3 patients were invalid. Conclusion:Zengfa Ling shows great effects on alopecia.%目的:通过临床实践交流补肝肾增发灵粉剂胶囊治疗肝肾不足型脱发的临床治疗效果。方法:选取191例肝肾不足型脱发患者服用补肝肾增发灵粉剂胶囊治疗3个月。结果:治疗观察191例患者,188例有治疗效果,3例无效。结论:增发丸治疗脱发临床效果显著。

  4. Presença de comorbidades como fator agravante de alopecia areata em crianças e adolescentes de 0 a 19 anos de idade no Hospital Universitário de Brasília

    OpenAIRE

    2011-01-01

    Alopecia areata é uma afecção crônica não cicatricial dos folículos pilosos, caracterizada por perda localizada ou difusa de cabelos ou pelos. Considerada doença autoimune mediada por células T, órgão-específica, onde uma infiltração linfocítica dos folículos pilosos resulta em ruptura de cabelos anágenos, ocasionando alopecia não inflamatória. Pode ocorrer em qualquer área corporal, sendo mais frequente em couro cabeludo e barba. Objetivos: O objetivo principal desta pesquisa foi investigar ...

  5. 斑秃患者生活质量评价方法的研究现状%Current Status of Studies on Evaluation of Quality of Life in Alopecia Areata

    Institute of Scientific and Technical Information of China (English)

    韩毓梅; 杨勤萍

    2011-01-01

    斑秃(alopecia areata)是一种快速发生的圆形或椭圆形片状脱发.受累范围小自一片头皮,大至整个头颅的全秃(alopecia totalis);甚至全身性脱发,称作普秃(alopecia universalis)[1].普通人群中,约0.2%的人群罹患斑秃[2],1.7%的人群在一生中会经历斑秃[3].斑秃这种迅速、突然、反复发作的特性,必然会对患者生活造成重大影响.临床上脱发程度的诊断,并不能很好地代表患者生活受损情况和内心感受[4],患者对疾病的想法可能与医师有很大的差异.生活质量(quality of life,QOL)与单纯的临床表现相比,是一种较好的测量标准,可以全面评价患病的严重性[ 5].

  6. Application of relay expansion for large cicatricial alopecia%接力扩张法在大面积瘢痕性秃发修复中的应用

    Institute of Scientific and Technical Information of China (English)

    刘烨; 朱飞; 宁金龙; 汪垠

    2012-01-01

    To investigate the clinical effect of relay expansion for large cicatricial alopecia. A single surgery was divided into two stages: In stage I , several soft tissue expanders were inserted in subgaleal plane, which would gradually spread the normal scalp organization; In stage II , the expanders were removed, and advanced expansion and rotation flaps were used to repair larger cicatricial alopecia. The surgery was relayed to repair the remaining large cicatricial alopecia with satisfactory result.%探讨应用接力扩张法修复大面积瘢痕性秃发的临床效果.手术分期进行:Ⅰ期按设计在头皮帽状腱膜下埋置扩张器,缓慢扩张正常头皮组织;Ⅱ期取出扩张器,推进或旋转扩张皮瓣修复部分瘢痕性秃发区,同时于头皮瓣下接力置放扩张器,待切口愈合良好后注水扩张;扩张过程完成后再次手术修复残余瘢痕秃发区.以此方法重复进行,直至瘢痕完全去除,效果满意.

  7. Progress on the pathologic mechanism and potential therapy of androgenic alopecia%脂溢性脱发的发生机制及治疗研究进展

    Institute of Scientific and Technical Information of China (English)

    巫珊; 张海州

    2012-01-01

    Pathologic mechanism and therapeutic methods of androgenic alopecia were discussed. Pathological representations, pathogenesis and therapeutically active ingredients of androgenic alopecia were introduced, and the relationship between cytokines and androgenic alopecia was disclosed. The active ingredients which may inhibit or stimulate related cytokines with traditional treatment for hairloss are presented and its application prospect is also discussed.%综述了脂溢性脱发的发生机制及活性物治疗研究进展。主要介绍了脂溢性脱发的病理表现、发生机制以及治疗活性物的研究现状。重点揭示了相关细胞因子对脂溢性脱发的影响。提出将具有相应细胞因子激励或抑制作用的活性物与常规的功能性成分联合应用在防脱发个人护理品中,将充分发挥其治疗效果,并对其应用前景进行了展望。

  8. Misdiagnosis of secondary syphilis with single complaints of alopecia:two cases report%仅表现为脱发的二期梅毒二例误诊报告

    Institute of Scientific and Technical Information of China (English)

    林挺

    2014-01-01

    Clinical symptoms of alopecia in secondary syphilis often misdiagnosed as other types of hair loss.Two cases of secondary syphilis with single complaints of alopecia are reported. The alopecia was presented as worm-biting like or diffused small patches. Diagnosis was made according to serologic tests or trep-onema pallidum examination.After treatment with benzathine penicillin,both patients recovered. Hair loss can provide clues to diagnosis of syphilis when it was the only manifestation.%仅表现为脱发症状的二期梅毒临床少见,常常误诊为其他类型的脱发。该文报道2例仅表现为脱发的二期梅毒患者,脱发表现为虫蚀状、弥漫性小片状,梅毒血清学试验阳性或梅毒螺旋体检查阳性。经苄星青霉素治疗后毛发再生。该文提示梅毒性脱发单独出现时,注意勿漏诊。

  9. The Evaluation of Efficacy and Safety of Topical Saw Palmetto and Trichogen Veg Complex for the Treatment of Androgenetic Alopecia in Men

    Directory of Open Access Journals (Sweden)

    Ercan Arca

    2014-12-01

    Full Text Available Objective: Androgenetic alopecia (AGA is a special type, characterized with the follicular miniaturization of the frontal and parietal areas of scalp. In this study, we intended to evaluate the efficacy and safety of a hair lotion including saw palmetto and 10% trichogen veg complex (TVC within male patients with AGA. Methods: Male patients, who treated with topical saw palmetto and TVC for four months between 2011-2012 were included to our study. Among the patient files, records of 25 patient were accepted available and taken into consideration according to the vertex photographs and tricoscan evaluations. Derived data were analyzed with SPSS program. Results: Total hair count was increased 11.9% compared with the pretreatment period. The final ratio of anagen/telogen hair was compared with the initials and the increase in ratio was 38%. According to the evaluation of vertex photographs, the observers declared that enhancement was noted in 48% of the patients and no difference was not noted in 36% of the patients. Conclusion: At the end of the study, topical saw palmetto and TVC were evaluated efficient and safe for the treatment of AGA. Randomized controlled trials among patient groups will reveal more conclusive data associated with topical saw palmetto and TVC.

  10. Avicequinone C Isolated from Avicennia marina Exhibits 5α-Reductase-Type 1 Inhibitory Activity Using an Androgenic Alopecia Relevant Cell-Based Assay System

    Directory of Open Access Journals (Sweden)

    Ruchy Jain

    2014-05-01

    Full Text Available Avicennia marina (AM exhibits various biological activities and has been traditionally used in Egypt to cure skin diseases. In this study, the methanolic heartwood extract of AM was evaluated for inhibitory activity against 5α-reductase (5α-R [E.C.1.3.99.5], the enzyme responsible for the over-production of 5α-dihydrotestosterone (5α-DHT causing androgenic alopecia (AGA. An AGA-relevant cell-based assay was developed using human hair dermal papilla cells (HHDPCs, the main regulator of hair growth and the only cells within the hair follicle that are the direct site of 5α-DHT action, combined with a non-radioactive thin layer chromatography (TLC detection technique. The results revealed that AM is a potent 5α-R type 1 (5α-R1 inhibitor, reducing the 5α-DHT production by 52% at the final concentration of 10 µg/mL. Activity-guided fractionation has led to the identification of avicequinone C, a furanonaphthaquinone, as a 5α-R1 inhibitor with an IC50 of 9.94 ± 0.33 µg/mL or 38.8 ± 1.29 µM. This paper is the first to report anti-androgenic activity through 5α-R1 inhibition of AM and avicequinone C.

  11. Epidemiological evidence of the association between lichen planus and two immune-related diseases. Alopecia areata and ulcerative colitis. Gruppo Italiano Studi Epidemiologici in Dermatologia.

    Science.gov (United States)

    1991-05-01

    Between September 1986 and February 1988, a case-control study involving 27 Italian dermatological centers collaborating in the Gruppo Italiano Studi Epidemiologici in Dermatologia was conducted, concerning the relationship between history of several medical conditions and exposures to drugs and the risk of lichen planus. The cases were all consecutive patients with a new diagnosis of lichen planus, and the controls were patients under dermatological care observed under the same conditions. A total of 711 cases and 1395 controls met the admission criteria and were interviewed by trained investigators. Patients with histories of alopecia areata were found to be at risk for lichen planus (relative risk = 2.7; 95% confidence interval, 1.1 to 6.5). Five patients (0.7%) in the group with lichen planus had a history of ulcerative colitis, while none of the controls had this disease. The risk of lichen planus was also increased in patients with a history of chronic active hepatitis, but this increase was not statistically significant (relative risk = 4.7; 95% confidence interval, 0.7 to 29.4).

  12. All hairstyles are not created equal: What the dermatologist needs to know about black hairstyling practices and the risk of traction alopecia (TA).

    Science.gov (United States)

    Haskin, Alessandra; Aguh, Crystal

    2016-09-01

    Prevalent among black women, traction alopecia (TA) is a type of hair loss that is often attributed to certain hairstyling practices. Although some of the hair care techniques common in the black community can promote ease of everyday hairstyling for black women, many of these practices have been implicated as risk factors for TA. Because of the limited literature on black hairstyling methods, hair loss in this patient population can present a diagnostic and therapeutic challenge for dermatologists. By increasing the knowledge and understanding of these practices and their risk of causing TA, clinicians can better manage this condition and stop the progression of hair loss before it becomes permanent. This information can be used to develop individualized recommendations for safer styling alternatives and improve patient education by identifying high-risk hairstyling habits. This review stratifies these hair care and styling practices into high-, moderate-, and low-risk categories, in addition to outlining a diagnostic approach for TA and detailed guidelines for conservative management.

  13. Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial

    Directory of Open Access Journals (Sweden)

    Young Hye Cho

    2014-01-01

    Full Text Available Pumpkin seed oil (PSO has been shown to block the action of 5-alpha reductase and to have antiandrogenic effects on rats. This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of PSO for treatment of hair growth in male patients with mild to moderate androgenetic alopecia (AGA. 76 male patients with AGA received 400 mg of PSO per day or a placebo for 24 weeks. Change over time in scalp hair growth was evaluated by four outcomes: assessment of standardized clinical photographs by a blinded investigator; patient self-assessment scores; scalp hair thickness; and scalp hair counts. Reports of adverse events were collected throughout the study. After 24 weeks of treatment, self-rated improvement score and self-rated satisfaction scores in the PSO-treated group were higher than in the placebo group (P = 0.013, 0.003. The PSO-treated group had more hair after treatment than at baseline, compared to the placebo group (P<0.001. Mean hair count increases of 40% were observed in PSO-treated men at 24 weeks, whereas increases of 10% were observed in placebo-treated men (P<0.001. Adverse effects were not different in the two groups.

  14. 高密度毛发移植术在瘢痕性脱发治疗中的应用%Application of high-density hair transplantation in treatment of cicatricial alopecia

    Institute of Scientific and Technical Information of China (English)

    张菊芳; 沈海燕; 韩蕾; 付丽; 郭晓波; 祝飞; 李金晟

    2011-01-01

    Objective To investigate the effect of high-density hair transplantation on the treatment of cicatricial alopecia and its features. Methods The units of transplanted hair follicle were counted according to the area of cicatricial alopecia and required hair density. Scalp strip from the occipital region ( donor site) was harvested, and then it was transplanted into the recipient sites ( cicatricial alopecia) after the taken scalp was made into hair follicle units with anatomic structure reservation by microscopic dissection. From January 2005 to December 2010 , totally 76 patients with cicatricial alopecia underwent the operation metioned above. Results After 6 ~ 18 months follow-up in 76 patients , excellent results ( complete cover) were achieved in 36 patients, good ( basic cover) in 24 patients, so-so (lower-density transplanted hair or part uncovered cicatricial alopecia ) in 16 patients. All cases were satisfied with the results except for 2 patients with epidermoid cysts which were healed with local treatments. Conclusion The high-density hair transplantation is a good method for treating cicatricial alopecia with such advantages as slight invasion, quick recovery , high transplanting density , high survival rate and satisfactory postoperative results. It is worth extending in clinic.%目的 探讨高密度毛发移植术在瘢痕性脱发修复中的疗效及其特点.方法 首先根据脱发区的面积及毛发的移植密度计算出移植毛囊的单位数;然后以患者的枕后部为供区,切取优势的头皮条,采用显微分割的方法将其制成保留正常解剖结构的毛囊单位后植入脱发区.自2005年1月至2010年12月,对76例瘢痕性脱发患者行高密度毛发移植术.结果 术后随访76例患者6~18个月,其中脱发区被完全覆盖者36例,为优;基本覆盖者24例,为良;毛发的密度较低,仍有部分脱发区外露者13例,为可;头皮瘢痕明显外露者3例,为差.移植后的

  15. GerminalPlum NeedleRing Detained for AcupunctureTreatment of Alopecia Areata%生发梅花针环压叩刺法治疗血瘀毛窍型斑秃的临床研究

    Institute of Scientific and Technical Information of China (English)

    高险峰; 徐百灵

    2013-01-01

    Purpose To describe the years application germinal plum needle ring detained for acupuncture treatment of alopecia areata .Methods The patients ran-domly divided into two groups,the treatment group with independent research and germinal plum needle ,take ring detained for acupuncture treatment;control group oral treatment of alopecia areata.Results Treatment group display efficiency of 90%;control group display efficiency 40%.Two sets of explicit efficiency comparison there are significant differences(p ﹤ 0.05).Conclusion Germinal plum needle is a new needle;central pressure for acupuncture treatment of alopecia areata is a new treatment efficacy.%目的介绍多年来应用生发梅花针环压叩刺法治疗血瘀毛窍型斑秃的临床研究。方法将患者随机分为两组,治疗组用自主研制的生发梅花针,采取环压叩刺法治疗;对照组用传统梅花针治疗。结果治疗组显效率90%;对照组显效率40%。两组显效率对比有显著差异( p﹤0.05)。结论生发梅花针是一种新型针具;环压叩刺法治疗血瘀毛窍型斑秃是一种疗效确切的新疗法。

  16. 旱地脂脱方联合梅花针叩刺治疗脂溢性脱发疗效观察%Observation of Han Di Zhi Tuo Fang Combined with Percussopunctator in Treating Alopecia Seborrhoeica

    Institute of Scientific and Technical Information of China (English)

    李恒

    2014-01-01

    目的:观察旱地脂脱方联合梅花针叩刺治疗脂溢性脱发的治疗效果。方法选择86例脂溢性脱发患者随机分为观察组和对照组各43例;对照组给予口服维生素B6片剂治疗,治疗组给予旱地脂脱方联合梅花针叩刺治疗。比较两组治疗效果。结果治疗组总有效率(88.37%)高于对照组(74.42%),差异有统计学意义(P<0.05)。结论旱地脂脱方联合梅花针叩刺治疗脂溢性脱发疗效显著,值得进一步推广。%ObjectTo analysis the effect of Han Di Zhi Tuo Fang combined with percussopunctator in treating alopecia seborrhoeica. Methods: 86 cases of alopecia seborrhoeica were divided into treatment group and control group with 43 cases. Control group were treated by Vitamin B6. Treatment group were treated with Han Di Zhi Tuo Fang combined with percussopunctator. The clinical effects of the two groups were observed. Results: The total effective rate in treatment group (88.37%) was significantly higher than control group (74.42%), the difference was statistical significance (p<0.05). Conclusion:The therapy of Han Di Zhi Tuo Fang combined with percussopunctator has a good effect in treating alopecia seborrhoeica, worth clinical promotion.

  17. Effect of Glycyrrhizin capsule and Yangxueshengfa on alopecia areata%复方甘草酸苷胶囊联合养血生发胶囊治疗斑秃临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    柳敏; 谢雪冰

    2012-01-01

    目的 观察复方甘草酸苷胶囊联合养血生发胶囊治疗斑秃的临床疗效.方法 将229例符合入选标准的患者随机分为两组,治疗组119例给予复方甘草酸苷胶囊和养血生发胶囊口服;对照组110例给予养血生发胶囊口服,疗程3个月,观察疗效.结果 治疗组有效率为98.3%,对照组有效率为80.0%,差异有显著性(x2=20.45,P<0.05).结论 复方甘草酸苷胶囊联合养血生发胶囊治疗斑秃,中西医结合,相辅相成,标本兼治,疗效确切,值得临床推广应用.%Objective To observe the effect of Glycyrrhizin capsule and Yangxueshengfa on alopecia areata. Method 229 patients with alopecia areata were randomly divided into two groups:Treatment group (119 cases) given glycyrrhizin capsules and oral Yangxueshengfa capsule and the control group (110 patients) given oral Yangxueshengfa capsule. Results The effective rate of treatment group and control group were 98. 3% and 80. 0% (Χ2 = 20. 45, P<0. 005). Conclusion It is effective to treat alopecia areata with glycyrrhizin capsule and Yangxueshengfa capsule.

  18. The investigation of helicobacter pylori infection and the serum level of vitamin D in thepatients with alopecia areata%斑秃患者血清维生素D水平及幽门螺杆菌感染情况的探讨

    Institute of Scientific and Technical Information of China (English)

    郑优优; 庄晓晟; 许嘉家; 胡莉芳; 孙蔚凌; 夏济平; 范卫新

    2013-01-01

    Objective: To investigate the infection of helicobacter pylori and the serum level of 25-hydroxy vitamin D in the patients with alopecia areata. Methods: The infection of helicobacter pylori in the gastrointestinal tract was measured with 13Carbon Urea Breath Test (13C-UBT) in the patients with alopecia areata and detected the serum level of 25-OH vitamin D in the patients with alopecia areata with the electrochemical luminescence assay respectively. Results; For the infection of the helicobacter pylori, no significant difference was found between the alopecia areata group and control group (P > 0.05). Same situation was also found in the illness stale, the course of disease and the disease severity within the alopecia areata patients group (P > 0.05). The detection of the vitamin D revealed that the serum level was distinctly lower in the patients with alopecia areata than that in the control group (P 0.05).同样,该感染与斑秃是否活动、患者的病程及斑秃的严重程度也都未发现明显相关性.血清25-(OH)-D检测发现,斑秃患者的水平明显低于健康对照组,而且,病程1年的患者.结论:Hp感染与斑秃的发病未发现明显相关性.维生素D的缺乏与斑秃有明显相关性.

  19. Diffuse alopecia areata is associated with intense inflammatory infiltration and CD8+ T cells in hair loss regions and an increase in serum IgE level

    Directory of Open Access Journals (Sweden)

    Ying Zhao

    2012-01-01

    Full Text Available Background: Mechanism leading to an abrupt hair loss in diffuse alopecia areata (AA remains unclear. Aims: To explore the characteristics of diffuse AA and possible factors involved in its pathogenesis. Methods: Clinical and laboratory data of 17 diffuse AA patients and 37 patchy AA patients were analyzed retrospectively. Serum IgE level was evaluated in all diffuse and patchy AA patients, as well as 27 healthy subjects without hair loss to serve as normal control. Univariate analysis was performed using Fisher′s exact test and Wilcoxon rank-sum test. Associations between inflammatory cell infiltration and laboratory values were analyzed using Spearman rank correlation test. Results: The mean age of patients with diffuse AA was 27 years with a mean disease duration of 1.77 months. All of them presented in spring or summer with an acute onset of diffuse hair loss preceded by higher incidence of scalp pruritus. Although no statistically significant difference on the incidence of atopic disease among three groups has been found, serum IgE level in diffuse AA was higher than that in healthy controls, but was comparable to that in patchy AA group. Histopathology of lesional scalp biopsies showed more intense infiltration comprising of mononuclear cells, eosinophils, CD3 + , and CD8 + T cells around hair bulbs in diffuse AA group than in patchy AA group. Moreover, IgE level in diffuse AA patients positively correlated with intensity of infiltration by mononuclear cells, eosinophils, and CD8 + T cells. Conclusions: Hypersensitivity may be involved in pathogenesis of diffuse AA. The acute onset of diffuse AA may be related to intense local inflammatory infiltration of hair loss region and an increase in serum IgE level.

  20. 多只扩张器超量扩张修复大面积瘢痕性秃发%Excessive expansion of scalp with multiple dilators to repair cicatricial alopecia in a large area

    Institute of Scientific and Technical Information of China (English)

    于仁义; 刘顺利; 陈铭锐; 刘本立; 卞东会; 武铠

    2014-01-01

    目的 探讨应用多只扩张器超量扩张头皮修复大面积瘢痕性秃发的临床效果.方法 Ⅰ期手术:根据秃发区的形状、面积大小,选择多只扩张器,在肿胀麻醉下,置于头部有发区帽状腱膜下,注射壶外置.超量扩张3~6个月,以获得额外有发头皮.Ⅱ期手术:将扩张器取出,切除瘢痕,将扩张后的有发头皮,采用滑行推进皮瓣、旋转皮瓣与易位皮瓣联合运用的手术方式,修复头皮秃发区.结果 23例患者术后秃发区修复效果良好,外观满意.结论 多只扩张器超量扩张可获得大量额外扩张头皮.合理设计皮瓣转移术,最大限度地提高了扩张皮肤的利用率,可修复大面积瘢痕性秃发,修复效果良好.%Objective To investigate the application of multiple dilators for excessive expansion of scalp with hair covering and integrated use of expanded flap to repair cicatricial alopecia in a large area.Methods stage Ⅰ surgery was performed as follows:multiple dilators were chosed and embedded below the galea aponeurotica of the scalp with hair covering according to the bald hair shape,size of the alopecia area.Excessive expansion was conducted for 3 to 6 months to get the extra hair scalp.Stage Ⅱ surgery was as follows:Dilators were removed and scar areas were resected,followed by combined use of sliding advancement flap,rotation flap and translocation flap to repair scalp alopecia.Resluts The postoperative effect of all patients was ideal with satisfied appearance.Conclusions Multiple dilator excessive expansion may obtain a large number of additional expansion scalp,combined by reasonable use of skin flap transfer technology,which can be used to repair the large scarring alopecia and get a good clinical effect.

  1. Deglutition of Shengfa Decoction Powder Combined with External Application of Drynaria in Treating 13 Cases of Alopecia Areata%吞服生发汤散剂合骨碎补外用治疗斑秃13例

    Institute of Scientific and Technical Information of China (English)

    陈志清; 叶明

    2013-01-01

    Objective:To observe the clinical therapeutic effect of deglutition of Shengfa decoction powder combined with external appli -cation of drynaria in treating alopecia areata. Methods:Thirteen patients suffered from alopecia areata patients received treatment of de -glutition of Shengfa decoction powder as well as external application of Drynaria soaked in rice vinegar . Patients were given 3 times of deglutition of Shengfa decoction , 3 to 6 grams each time. Besides, external application were given 3 to 4 times a day on the affected areas which were made from 50 grams of drynaria powder soaked in 250 ml of rice vinegar for 24 hours. Results: Among the 13 cases of alopecia areata patients, 11 cases was effective , and 2 were invalid with a total effective rate of 84. 6%. Conclusion: Deglutition of Shengfa decoction powder combined with external application of drynaria in treating alopecia areata shows satisfactory therapeutic effect , especially on those who cannot be applied with oral administration of decoctions . The therapy is convenient and economical , which is worth generalizing.%目的:观察吞服生发汤散剂合骨碎补外用治疗斑秃的临床疗效.方法:13例斑秃患者均采取吞服生发汤散剂合骨碎补浸泡米醋外用的方法,每日吞服生发汤散剂3次,每次3~6 g,外治以50g骨碎补粉浸泡于250 mL米醋中,24 h后取浸液擦患处,每日擦3~4次.结果:13例斑秃患者中有效11例,无效2例,总有效率为84.6%.结论:吞服生发汤散剂合骨碎补外用治疗斑秃疗效好,尤其适用于不能坚持服用汤药及不便应用汤剂的患者.该法应用方便,且极具药物经济学意义,值得推广.

  2. The Effect of Mental Stress on Alopecia Areata Incidence in C3H/HeJ Mice%精神压力对C3H/HeJ小鼠斑秃发病率的影响

    Institute of Scientific and Technical Information of China (English)

    汤球; 蔡丽萍; 江鹏亮

    2011-01-01

    Objective To study the effect of mental stress on the alopecia areata incidence in C3H/HeJ mice. Methods Eighty C3H/HeJ mice were selected and randomly divided into 4 groups: mental stress group, drug-induced group, mental stress and drug-induced group, and control group, each group including 20 mice. Follow-up a period and observe the incidence of alopecia areata after intervention, and compare the differences among groups. Results The alopecia areata incidence of mental stress group was 10%, the control group did not occur; the incidence of mental stress and drug-induced group was 90%, incidence of drug-induced group was 60%, the difference was statistically significant (P<0.05).Conclusion The mental stress significantly increased the alopecia areata incidence of C3H/HeJ mouse.%目的 研究精神压力对C3H/HeJ小鼠斑秃发病率的影响.方法 选取C3H/HeJ小鼠80只,随机分为4组,即精神压力组、药物诱导组、精神压力与药物诱导组和对照组,每组20只,干预后观察4个月,统计斑秃发病率,并比较各组差异.结果 精神压力组斑秃发病率为10%,对照组没有发生;精神压力与药物诱导组发病率为90%,药物诱导组发病率为60%,差异有统计学意义(P<0.05).结论 精神压力在药物诱导下显著提高C3H/HeJ小鼠斑秃发病率.

  3. 斑秃治疗的疗效观察以及免疫功能紊乱的研究%The treatment of alopecia areata and autoimmune disorders

    Institute of Scientific and Technical Information of China (English)

    张炜

    2014-01-01

    目的:观察卡介菌多糖核酸注射液(迪苏)联合5%米诺地尔酊(蔓迪)治疗斑秃疗效进行斑秃免疫功能紊乱的研究。方法:60例斑秃患者分为两组,分别采用卡介菌多糖核酸注射液联合5%米诺地尔酊治疗(联合治疗组)、单用卡介菌多糖核酸治疗(对照组)。同时对60例患者进行自身血清皮肤试验。结果:两组临床治疗效果差异有统计学意义,X2=4.1761,P=0.041;自身血清皮肤试验的阳性率为68.33%。结论:本研究提示自身免疫功能紊乱参与斑秃的发病,联合多途径治疗斑秃的方法在临床上值得推广。%Objective:To observe the clinical eficacy of BCG-polysaccharide nucleic acid with minoxidil in the treatment of alopecia areata and autoimmune disorders areata.Methods:60 cases of alopecia areata patients were randomLy divided into 2 groups.BCG-polysaccharide nucleic acid combined with minoxidil was used in group 1,BCG-polysaccharide nucleic acid alone was usedin group 2. At the same time, we determinated 60 cases of patients with autologous serum .Results:Clinical therapeutic effects of the two groups had significant difference,X2=4.1761,P=0.041;autologous serum skin test positivity rate was 68.33%.Conclusion:This study suggests that the autoimmune disorders in alopecia areata,. Multiple pathways of alopecia areata treatment method is valuable in clinical use.

  4. Clinical efficacy of 308 nm excimer laser in the treatment of 42 alopecia areata patients%308 nm准分子激光治疗斑秃42例疗效观察

    Institute of Scientific and Technical Information of China (English)

    梁俊琴; 彭艳玲; 普雄明

    2009-01-01

    目的 观察308 nm准分子激光治疗斑秃临床疗效及安全性.方法 :试验组用308 nm准分子激光对42例斑秃患者进行每周2~3次照射治疗并观察疗效.对照组:用浓度为5 mg/mL的曲安奈德液头部皮损内注射,沣射4~6周后观察疗效.结果 试验组与对照组差异具有统计学意义,试验组疗效好于对照组.试验组中有2例患者经过308 nm准分子激光5次后即有效,其余治疗有效患者中平均照射次数9.1次.结论 308 nm准分子激光治疗斑秃安全,有效,患者依从性较高.%Objective To observe the clinical efficacy and safety of 308 nm excimer laser treat alopecia areata patients.Methods 42 alopecia areata patients as test group are treated with 308 nm excimer laser 2-3 times a week and observe the effect of radiation treatment.30 alopecia aleata patients as Control group are treated by injectting the concentration of 5 mg/mL triamcinolone acetonideion fluid in the head lesions,4-6 weeks later observed effect.Results Test group and control group have statistically significant difference.Efficacy of the test group was better than the control group In test group two patients get Effective treatment after five times with 308 nm excimer laser treatment.The rest of the effective treatment of patients can get Effective treatment with an average of 9.1 times.Conclusion 308 nm excimer laser treat alopecia areata are more safe and effective,and patients have high compliance.

  5. 雄源遗传性脱发的病因研究及相关治疗进展%The related therapeutic and pathogeny study progress of androgenetic alopecia

    Institute of Scientific and Technical Information of China (English)

    雷鸣; 范金财

    2008-01-01

    雄源遗传性脱发(androgenetic alopecia,AGA)是一种雄激素依赖性的遗传性毛发脱落病。过去又称寻常秃发(Common baldness)、早秃(Alopecia Prematura)或脂溢性脱发(Seborrheic Alopecia)。AGA的发生和进展取决于内分泌因子和遗传易感性的相互作用。

  6. Estudio de la prevalencia de disfunción y autoinmunidad tiroidea en pacientes con urticaria crónica, vitíligo y alopecia areata en la comunidad autónoma de Cantabria

    OpenAIRE

    Díaz Angulo, Sara

    2015-01-01

    RESUMEN: Se comparó la prevalencia de autoinmunidad tiroidea (AT) en pacientes con urticaria crónica espontánea (UCE), alopecia areata (AA), vitíligo no segmentario (VNS) y controles. El trabajo consistió en un estudio de casos y controles que incluyó 343 pacientes con UCE, 54 con AA, 71 con VNS y 282 controles sanos emparejados por edad y sexo. La frecuencia de autoanticuerpos anti-tiroideos (ATA) fue de 26,8%, 31% y 24,1% en pacientes con UCE, VNS y AA, respectivamente, en comparación con 2...

  7. Using Soft Tissue Expander in the Treatment for Scar Alopecia%软组织扩张器治疗学龄前儿童瘢痕性秃发

    Institute of Scientific and Technical Information of China (English)

    王善昌; 陈方龙; 李金玉

    1990-01-01

    1989年我科采用国产乳胶硅胶软组织扩张器治疗5例学龄前儿童瘢痕性秃发.经我科在技术上改进后,瘢痕切除率均为100%,无严重并发症,平均治疗过程为25天.本方法具有快速、简便和有效等优点.%Scar alopecia of 5 pre school children vere treated with siliceous gel soft tissue expander in 1989. After expansion, the sear tissues were all resected without major complications. The average hospitalization was 25 days. Scar alopecia is a big mental burden to the patients and parents. Being improved by the authors, this procedure has become more simple, effective and convenient. The results of the conventional operations such as rotation flap and excision of scar by stages are not so satisfactory as this tissue expansion procedure.

  8. Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region.

    Science.gov (United States)

    Tazi-Ahnini, R; di Giovine, F S; McDonagh, A J; Messenger, A G; Amadou, C; Cox, A; Duff, G W; Cork, M J

    2000-06-01

    Alopecia areata (AA) is a chronic inflammatory disease characterised by patchy hair loss with T cell infiltration of hair follicles. AA occurs in approximately 0.1% of the general population, but this is increased to 9% in Down syndrome (DS). DS is associated with an additional copy (full or partial) of chromosome 21, and the DS region may potentially include genes involved in the pathogenesis of AA. MX1 is the gene encoding the interferon-induced p78 protein (MxA). MxA protein confers resistance to influenza viruses, and we have previously shown that MxA protein is strongly expressed in lesional anagen hair bulbs from patients with AA but not in normal follicles. We therefore studied the possible involvement of MX1 in the pathogenesis of AA. To establish markers in the MX1 region which could be screened by PCR-based methods, we defined the human MX1 exon/intron organisation and screened the exons and the introns by conformation-sensitive gel electrophoresis. We found that the MX1 gene contains 17 exons extending over 33 kb. The size and sequence of the region from exon 6 to exon 16 are highly conserved between human and mouse. Screening of 4747 bp within the MX1 gene revealed four single nucleotide polymorphisms in intron 6. These polymorphisms are concentrated within 147 bp and show strong linkage disequilibrium. In a case-control association study for the MX1 (+9959) polymorphism in 165 AA patients and 510 controls we found a significant association of this marker with AA (odds ratio 1.79, 95% CI 1.21-2.66, chi2 = 8.464, P = 0.0036). The risk of disease was greater for patchy AA (mild disease) and with early age at onset (odds ratio 2.34, 95% CI 1.24-4.43, P = 0.0072), providing new evidence of genetic heterogeneity in AA. Our demonstration of genetic association between the MX1 gene and disease supports the hypothesis that this is a new candidate gene in AA.

  9. Updates on Clinical Management of Primary Cicatricial Alopecia%原发性瘢痕性脱发的研究进展

    Institute of Scientific and Technical Information of China (English)

    章星琪

    2013-01-01

    原发性瘢痕性脱发是一组以毛囊为中心受到永久性和炎症性破坏为特征的脱发性疾病,病因不明.按病理特点分为淋巴细胞性(如盘状红斑狼疮脱发和毛囊扁平苔藓)、中性粒细胞性(如脱发性毛囊炎和分割性蜂窝织炎/毛囊炎)、混合性(如瘢痕疙瘩性毛囊炎/痤疮)和非特异性4类本病有不可复性,如不能及时而有效的接受治疗,进展到瘢痕晚期会导致永久脱发.治疗可阻止病变发展,但不能彻底根治,故本病易反复发作.本文对原发性瘢痕性脱发的诊断、治疗和发病机制等进展进行综述.%Primary cicatricial alopecia ( PCA ) include a group of disqrders characterized by permanent destruction of the hair follicle and irreversible hair loss caused by inflammatory infiltration, with unknown etiology. The commonly used classification of PCA is based on pathology findings and divided it into lymphocytic such as discoid lupus and lichen planopalaris, neutrophilic such as folliculitis decalvans, mixed such as folliculitis (acne) keloidalis and nonspecific. Because of its irreversibility, once diagnosed, effective management should be installed to prevent scarring stage. However, treatment is only to arrest the progress of the disease, but not to eradicate the disorder, because of the largely unknown cause and pathogenesis. Details of classification, diagnosis, options for management and etiology of PCA are now focus in international hair research field and it will be discussed in this review.

  10. 毛囊活检在雄性激素源性脱发中的临床意义%Clinical significance of hair follicle biopsy in androgenetic alopecia patients

    Institute of Scientific and Technical Information of China (English)

    梁皓; 赵云杰; 金磊; 涂艳; 陈波

    2014-01-01

    目的:探讨雄性激素源性脱发(androgenetic alopecia,AGA)患者毛囊活检的临床意义。方法采用毛囊活检方法获取雄性激素源性脱发患者顶部、枕部以及非脱发者顶部毛囊及周围组织标本,观察苏木精-伊红(hematoxylin-eosinstaining, HE)染色并用免疫组织化学法检测雄性激素受体(androgen receptor,AR)的表达。结果患者顶部毛囊及周围组织中HE染色可见单一核细胞浸润,AR表达率79.17%,明显强于枕部(20.83%)和非脱发者顶部(20%)(P0.05)。结论毛囊活检为AGA早期诊断和鉴别诊断提供了手段,也为雄性激素源性脱发患者早期防治提供了依据。%Objective To investigate the clinical significance of the hair follicle biopsy to androgenetic alopecia (AGA) pa-tients. Methods We used the hair follicle biopsy technique to obtain the top and the occipital hair follicles and the surrounding tissue of AGA patients and the top of non-alopecia as specimens,and observed the hematoxylin-eosinstaining (HE) staining,and immunohistochemical method was used to detect the androgen receptor (AR) expression. Results The mononuclear cells infiltra-tion were found in the top of AGA’hair follicles and the surrounding tissue by HE staining,the expression of AR was stronger than the occipital of AGA and the top of non-alopecia (P0.05). Conclusion Hair follicle biopsy provides a means for diagnosis and dif-ferential diagnosis of early AGA. It also provides the basis for early prevention of AGA.

  11. Hair transplantation in alopecia androgenetica

    Directory of Open Access Journals (Sweden)

    Singh Gurinderjit

    1992-01-01

    Full Text Available One hundred patients suffering from male pattern baldness were given 3 to 4 sittings of hair transplantation at an interval of about 4 to 6 weeks each. They included 46 patients of type III baldness, 23 patients of type III (vertex baldness, and 31 patients of type IV baldness. It needed 3 sittings in type III as well as type III (vertex patients, whereas type IV patients needed 4 sittings for cosmetically acceptable results. Sixty percent patients of type III (including type III vertex showed excellent results; whereas 24 percent patients showed good response. Thirty-four percent patients of type IV got excellent cosmetic appearance; whereas, good results could be obtained in 17 percent patients. The reasons for poor results in certain patients were poor density of hair at donor sites and poor growth of hair in some of the transplanted plugs.

  12. Genetic Underpinnings of Alopecia Areata

    Medline Plus

    Full Text Available ... navigation and go to main content of page. Portal en español | Asian Language Publications Enter Search Text '); ... Health Information | Research | Funding | News & Events | About Us | Portal en español | Asian-Language Publications Contact Us | Disclaimer | ...

  13. Genetics Home Reference: androgenetic alopecia

    Science.gov (United States)

    ... loss is associated with an increased risk of polycystic ovary syndrome (PCOS). PCOS is characterized by a hormonal imbalance that can lead to irregular menstruation, acne, excess hair elsewhere on the body (hirsutism), and ...

  14. Pharmacological and Experimental Study of Chinese Medicinal Herb in Treating Androgenetic Alopecia%中草药治疗雄激素性脱发的药理与实验研究概况

    Institute of Scientific and Technical Information of China (English)

    刘维; 陈达灿

    2003-01-01

    雄激素性脱发(androgenetie alopecia,AGA),又称男性型脱发(male pattern alopecia,MPA)、脂溢性脱发(sebrrheic alopecia,SA),是皮肤科临床的常见病、多发病。现代医学认为AGA是一种雄激素依赖的常染色体显性多基因遗传性秃发,其发病与雄激素代谢增多、毛囊单位的5α-还原酶水平增高等因素直接相关。目前采用中医药治疗AGA已取得了一定的临床疗效。

  15. Plastic surgical management of large cicatrical scalp alopecia%大面积瘢痕性秃发的外科手术治疗

    Institute of Scientific and Technical Information of China (English)

    范金财; 王继萍

    2009-01-01

    于颞顶区稳定性瘢痕性秃发的治疗.头皮组织扩张术适合于头皮各个区域瘢痕性秃发的治疗,其缺点是周期长、治疗过程复杂和切El遗留瘢痕影响外观等.对于秃发面积超过50%的患者,组织扩张术的疗效优于毛发单位移植术.%Objective To investigate the proper ways to manage a large cícatíical scalp alopeeia.Methodls Based on location,size and condition of scarring Iesiorm,218 patients with 20%-75%scarring alopecia were selected and treated with either dense-packing hair grafting technique(136 cases)or tissue expansion(82 cases).There were 209 in burn,5 in avulsed iniury and 4 in tumor excision.The lesions with tIIick.stable scars in the frontal or/and temporal areas underwent either hair grafting or tissue expansion process as desired by the patients.In addition,the alopecia in an unstable scar on the skull,with skull defect under the lesion and the lesion involved in the back of head was only treated with tissue expansion.The hair-grafting technique was carried out by harvesting a scalp strip from the back of head,then dividing it into a series of 1-3 hair grafts and finally implanting them into the prepared recipient holes of lesion with a desired hair direction.Ten areas with 1 cm2 size in 10 patients were randomly selected to examine the hair survival OVer 8 months post-operation.Tissue expansion was performed by firstly positioning a tissue expander in the subgaleal pocket of scalp and subsequently inflating it with normal saline in 5-7 days intervals for about 3 months. Thereafter, an expanded scalp flap was designed, with the combination of advancement and rotation flap transplantation principles, to be transferred to the recipient site after lesion removal. Results In patients with hair-grafting technique, hair density reached 60 -80 hairs/cm2 per session. Over an 8-month follow-up, the grafted hairs grew well with 98% hair survival. Forty-five patients with 20% -30% scalp hair loss achieved

  16. 骨碎补外用对环磷酰胺致小鼠斑秃模型的影响%Experimental effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in mice

    Institute of Scientific and Technical Information of China (English)

    黄云英; 张德芹; 沈丽; 王雪妮; 杜娟; 王元元

    2012-01-01

    [目的]考察骨碎补外用对环磷酰胺致C57BL/6小鼠斑秃模型的影响.[方法]采用环磷酰胺腹腔注射建立C57BL/6小鼠斑秃模型,观察骨碎补外用对小鼠毛囊组织学变化和血清细胞间黏附蛋白(ICAM-1)、内皮细胞-白细胞黏附分子-1(ELAM-1)水平的影响.[结果]骨碎补外用能使实验性斑秃模型小鼠血清ICAM-1和ELAM-1水平降低,毛囊数增多(P<0.05或P<0.01).[结论]骨碎补外用能够抑制毛囊进入退行期,对斑秃模型小鼠具有治疗作用.%[Objective] To investigate the effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in CS7BL/6 mice. [Methods] Severe alopecia was induced by cyclophosphamide in these mice. The hair growth and histological changes were observed in the back skin of them. The levels of ICAM-1 and ELAM-1 in the serum were determined by ELISA. [Results] The levels of ICAM-1 and ELAM-1 in herbal group were lower than that in the control group. The nutrition of hair follicles was also improved. [Conclusions] The extract from Drynaria fortunei has a promoting effect on the hair growth by its external application.

  17. Efficacy and tolerance of 2,3-diphenylcyclopropenone in propylene glycol versus 2,3-diphenylcyclopropenone in isopropanol – a novel formula designed for the treatment of alopecia areata

    Directory of Open Access Journals (Sweden)

    Tomasz Wasyłyszyn

    2017-01-01

    Full Text Available Introduction: Topical immunotherapy of alopecia areata (AA with contact allergens including 2,3-diphenylcyclopropenone (DCP have been used for few decades. Aim: The study introduces a new preparation of DCP in isopropanol for the purpose of the treatment of AA. The aim of the study was to compare new formula with the previously used DCP in propylene glycol. Two groups of twenty patients each, treated with new and old formula respectively were observed for one year. Treatment efficacy and tolerance was then measured and compared. Result: All but one patient responded to the study with partial or complete hair regrowth. Results show improvement after the treatment in both groups with 75% and 85% of patients with cosmetically acceptable hair amount (grades 1 and 2 in the hair loss scale in DCP in isopropanole and DCP in propylene glycol groups respectively. Complete hair regrowth was obtained in 35% and 25% of patients respectively. Differences in treatment’s efficacy between groups were not statistically important (p = 0.95. Tolerance was generally good but significantly better (p= 0.17 in a group treated with DCP in isopropanol. Discussion: DCP solutions in isopropanol may have potential in the treatment of alopecia areata. Treatment efficacy in both groups (DCP in propylene glycol and DCP in isopropanol was the same. Tolerance of the DCP in isopropanol was significantly better than DCP in propylene glycol. Despite better tolerance of DCP in isopropanol during the proper treatment, the sensitization with 3% DCP should be done with the solution in propylene glycol.

  18. Detection of interleukin-10 and transforming growth factor-β1 in the culture supernatant of CD4+CD25+ T cells from patients with alopecia areata%斑秃患者外周血CD4+CD25+T细胞培养上清液白介素10和转化生长因子β1检测

    Institute of Scientific and Technical Information of China (English)

    马新华; 邵文俊; 金宛宛; 高宇

    2014-01-01

    Objective To evaluate the potential association of CD4+CD25+ T cells with alopecia areata.Methods Totally,this study enrolled 23 patients with progressive alopecia areata,25 patients with stable alopecia areata,and 25 healthy controls.Peripheral blood was isolated from these subjects followed by isolation of CD4+ CD25+ regulatory T cells,which were then cuhured with the presence of anti-CD3 and-CD28 monoclonal antibodies for four days.Subsequently,enzyme-linked immunosorbent assay was performed to measure the levels of interleukin (IL)-10 and transforming growth factor (TGF)-β1 in the culture supematant of these T cells.Results The levels of IL-10 and TGF-β1 were (31.68 ± 6.78) pg/ml and (32.29 ± 6.8) pg/ml respectively in the culture supernatant of CD4+CD25+ regulatory T cells from patients with progressive alopecia areata,significantly lower than those from the healthy controls ((57.34 ± 14.15) pg/ml and (57.43 ± 15.16) pg/ml,both P < 0.05) and patients with stable alopecia areata ((52.56 ± 13.02) pg/ml and (61.75 ± 14.10) pg/ml,both P < 0.05).However,no significant difference was observed in the supernatant levels of IL-10 or TGF-β1 between the healthy controls and patients with stable alopecia areata.Conclusions The secretion of IL-10 and TGF-β1 by CD4+CD25+ T cells is decreased in patients with progressive alopecia areata,which may contribute to the pathogenesis of alopecia areata.%目的 探讨CD4+CD25+T细胞与斑秃发病之间的关系.方法 收集了3组研究对象,其中健康对照组25例、稳定期斑秃患者25例、进展期斑秃患者23例.抽取所有对象外周血,提取CD4+CD25+T细胞,培养4d,收集培养上清液,ELISA法检测上清液IL-10和TGF-β1水平.结果 进展期斑秃患者外周血CD4+CD25+T细胞培养的IL-10和TGF-β1分别为(31.68±6.78) pg/ml和(32.29±6.80) pg/ml,明显低于健康对照组(57.34±14.15) pg/ml、(57.43±15.16) pg/ml和稳定期斑秃患者(52.56±13.02) pg/ml和(61.75±14.10) pg

  19. Abnormal expression of VDR in the hair follicle of alopecia areata%维生素D受体在斑秃皮损处毛囊的异常表达

    Institute of Scientific and Technical Information of China (English)

    蔡泽明; 张斌; 赵莹; 西兰; 巩毓刚; 章星琪

    2011-01-01

    目的 观察维生素D受体(VDR)在斑秃患者及正常人毛囊中的表达情况.方法 分别通过荧光定量PCR及免疫组化法检测24例斑片型斑秃患者及12例正常人头皮生长期毛囊中维生素D受体的mRNA及蛋白表达水平,并比较斑秃患者不同脱发面积、发病年龄、病程与维生素D受体表达水平高低之间关系.结果 斑秃患者生长期毛囊VDR的mRNA及蛋白表达水平显著低于于正常人,但不同发病年龄、脱发面积、病程斑秃患者VDR表达水平差异无显著性.结论 维生素D受体在斑秃患者毛囊的表达低于正常人,可能在斑秃发病中起作用.%Objective To detect the expression of Vitamin D receptor ( VDR ) in the hair follicles of alopecia areata and healthy subjects. Methods Expression of VDR at both protein and mRNA levels in hair follicles of 12 controls and 24 alopecia areata ( AA ) patients were examined by immunohistochemistry and fluorescence quantitative PCR, respectively. VDR expression among AA patients with different onset age, disease course and hair loss area was analyzed. Results Compared with normal controls, the expression of VDR in hair follicle at protein and mRNA levels in AA were significantly reduced. However, there was no significant difference in VDR expression among AA patients with different onset age, disease course and hair loss area. Conclusion Low VDR protein and mRNA expression in the hair follicles of AA patients may play an important role in pathogenesis of AA.

  20. 肝肾不足型重型斑秃患者血皮质醇及糖皮质激素受体mRNA的表达状况%Serum cortisol and peripheral blood mononuclear cell glucocorticoid receptor mRNA expression in severe alopecia areata with liver-kidney deficiency syndrome

    Institute of Scientific and Technical Information of China (English)

    陈修漾; 陈达灿; 陈建宏; 危建安

    2012-01-01

    目的 探讨肝肾不足型重型斑秃患者血皮质醇、外周血单个核细胞(PBMC)中糖皮质激素受体mRNA(GRmRNA)表达状况与斑秃发病关系.方法 采用化学发光法检测23例肝肾不足型重型斑秃患者血皮质醇表达水平,并用逆转录-实时荧光定量聚合酶链反应分别检测该23例患者应用糖皮质激素(GC)治疗前后PBMC中GRmRNA表达水平,并与20例正常对照组相对比.结果 重型斑秃组与正常对照组两组血清皮质醇水平差异无统计学意义(P>0.05),重型斑秃组治疗前、后GRmRNA表达水平均低于正常对照组(P<0.05),并且治疗后GRmRNA表达水平比治疗前更低(P<0.01).结论 重型斑秃患者存在GC-GR紊乱,GRmRNA表达水平降低可能参与了重型斑秃的发病机制.肝肾不足型重型斑秃患者PBMC中GR mRNA表达水平显著低于正常对照组,这可能是重型斑秃肝肾不足证型在受体及基因水平上的病理变化,也可能是重型斑秃肝肾不足证型的微观本质之一.%Objective To investigate serum cortisol level and glucocorticoid receptors (GR) mRNA expression in peripheral blood mononuclear cells (PBMCs) in patients with severe alopecia areata and liver-kidney deficiency syndrome and their involvement in the pathogenesis of severe alopecia areata. Methods In 32 patients with severe alopecia areata, serum cortisol levels were measured by chemiluminescence assay and GR mRNA expression in the PBMCs was detected using reverse transcription real-time fluorescence quantitative PCR before and after treatment, with 20 normal subjects serving as the controls. Results Serum cortisol level showed no significant difference between the cases and the normal controls (P>0.05). The expression of GR mRNA in the PBMCs was significantly lower in the patients than in the normal controls (P<0.05). The expression of GR mRNA was even lower after treatments in patients with alopecia areata (P<0.01). Conclusion GC-GR disorder exists in

  1. 全身性苔藓样结节病伴秃发1例国内首报%The First Case of Generalized Lichenoid Sarcoidosis with Alopecia in China

    Institute of Scientific and Technical Information of China (English)

    李伯埙; 陈玉平; 耿松梅

    2011-01-01

    We reported the first case of generalized lichenoid sarcoidosis with alopecia in China. The patient was a 18-year-old young man who was affected by multiple papules in obdomen and nuchae in the beginning, which developed and spreaded to whole body during the following 11 years. Two years ago,the patient was found hair loss. Laboratory examination revcaled negative result to tuberculin reaction and normal chest X-ray. Skin biopsy from abdomen showed a non-caseating granu1oma infiltration of epitheloid cells in upper dermis. Silver staining found reticular fibers surround and permeate the epithelioid cell granuloma.%报告国内首例全身性苔藓样结节病1例.患者男,18岁,11年前腹部及项部出现数个绿豆大、肤色的丘疹,后皮损继续增多,并蔓延至全身.2年前出现脱发.胸部X线片正常,结核菌素试验阴性.腹部丘疹组织病理示:真皮上层呈非千酪坏死性上皮样细胞肉芽肿,染色示:网状纤维围绕并渗入上皮样肉芽肿.

  2. 皮肤针加外涂自配中药酊剂叩刺治疗斑秃的疗效观察%The Curative Effect Observation of Skin Needle and Chinese Medicine Tincture Tapping in the Treatment of Alopecia Areata

    Institute of Scientific and Technical Information of China (English)

    石俊

    2014-01-01

    To observe the curative effect of skin needled and chinese medicine with tincture from tapping in the treatment of alopecia areata.Method:51 patients with alopecia areata were divided into group A(26 cases)and group B,group A were cured by skin needle and chinese medicine tincture tapping ,and group B(25patients) were coated with 75%ethanol.Result:The effective rate of group A was 84.6%,and group B was 16.0%,there was significant difference(χ 2=24.01,P<0.01).Conclusion:Skin needle and chinese medicine with tincture from tapping can be used as an effective treatment for alopecia areata.%目的:观察皮肤针加外涂自配中药酊剂叩刺治疗斑秃的疗效。方法:选择51例斑秃患者,将其分为A组(26例),采用皮肤针加外涂自配中药酊剂叩刺治疗,B组(25例)外搽75%乙醇。结果:A组有效率为84.6%,B组为16.0%,两组比较差异有统计学意义(χ2=24.01,P<0.01)。结论:皮肤针加外涂自配中药酊剂叩刺可作为治疗斑秃的有效方法。

  3. Clinical Research of Lingdan Tablets and Wuling Capsules in the Treatment of Alopecia Areate%灵丹片联合乌灵胶囊治疗斑秃疗效观察

    Institute of Scientific and Technical Information of China (English)

    付昱; 杨静; 魏义花

    2015-01-01

    目的::探讨灵丹片联合乌灵胶囊内服治疗斑秃的临床疗效及安全性。方法:84例患者随机分为对照组和观察组各42例。两组均外用米诺地尔酊,对照组口服灵丹片0.9 g,tid;观察组在对照组基础上加用乌灵胶囊0.99 g,po,tid。两组疗程均为4个月。治疗前后比较患者脱发面积及部位、轻拉发试验及毛发生长情况评分变化,进行治疗前后采用匹兹堡睡眠质量指数(PSQI)评分。结果:观察组疗效优于对照组(P<0.05)。治疗后,两组主要症状、体征和PSQI评分均较治疗前下降(P<0.01);且观察组的主要症状、体征和PSQI评分明显低于对照组(P<0.01)。不良反应轻微。结论:灵丹片联合乌灵胶囊内服可以改善睡眠质量、促进头发的生长,提高临床疗效。%Objective:To analyze the clinical effect and safety of Lingdan tablets and Wuling capsules in the treatment of alopecia areate. Methods:Totally 84 patients with alopecia areate were divided into the observation group and the control group with 42 ones in each. Minoxidil tincture was used for external in the two groups. The control group were treated with 0. 9 g Lindan tablets, tid, for 4 months and the treatment group was additionally treated with 0. 99 g Wuling capsules,po,tid, for 4 months. The changes in the area and position of trichomadesis, light pull test, the tissue growth score and Pittsburgh Sleep Quality Index ( PSQI) score were compared before and after the treatment. Results:The efficacy of the observation group was better than that of the control group(P<0. 05). Af-ter the treatment, the evaluated indices in the two groups were lower than those before the treatment(P<0. 01), and the reduction of the observation group was more significant than that of the control group(P<0. 01) . There was no notable adverse reaction appeared in the observation group. Conclusion:Lingdan tablets and Wuling capsules can improve sleeping quality, promote the

  4. 应用FUT加FUE组合手术方法治疗大面积秃发%Treating large area of alopecia by Follicular Units Transplantation combined with Follicular Units Extraction

    Institute of Scientific and Technical Information of China (English)

    邹建红; 李兴东; 杨聪智; 马贵才; 闭陆祥

    2015-01-01

    目的:探讨应用FUT加FUE组合的手术方法,一次手术完成大面积秃发的植发问题。方法:笔者自2010年1月至2014年10月间应用FUT加FUE组合手术方法,对1179例大面积秃发患者行植发术予以治疗,其中男性996例,女性183例。结果:1179例大面积秃发者应用FUT加FUE组合手术方法,可以一次性完成大面积的植发问题,而且毛发成活率高,效果良好。结论:该方法比单纯FUT或FUE方法所取毛发的量大,从而解决了过去需2~3次手术才能完成的大面积植发问题,可有效解决大面积秃发难题。%Objective To investigate the application of FUT and FUE combination operation method on baldness patients.It can be a complete large bald hair transplant surgery. Results 1179 cases of large area baldness were applied FUT and FUE combination operation method.Large areas of hair transplant problem was completed.And hair survival rate was high,effect was good. Conclusion This method is suitable for large area alopecia.Than simple FUT or FUE method takes hair amount is large, resolved the large hair transplant problems that the need to 2-3 times in the past operation to complete.

  5. Traditional Chinese Medicine Treatment of The Model of Androgenetic Alopecia%中药生发擦剂治疗雄激素性脱发的实验研究

    Institute of Scientific and Technical Information of China (English)

    李荣群; 卜夏威; 景佐

    2013-01-01

    目的:观察所选中药擦剂对雄激素性脱发模型的治疗作用.方法:在所建立的大鼠脱发模型上用所选中药擦剂分高、低浓度剂量涂于背部患处,观察记录大鼠背部毛发生长情况,通过测定血清雄激素的含量以及皮肤HE染色切片,综合分析该中药擦剂对毛发生长和毛囊形态结构的影响.结果:与模型组相比,药物治疗组的毛发生长毛囊恢复生长,且高浓度组较低浓度效果更佳明显.结论:该中药擦剂具有治疗作用.%Objective: To observe the therapeutic effects of selected traditional Chinese medicine liniment on the model of androgenetic alopecia. Methods :On the basis of the established rat hair loss model, Take selected traditional Chinese medicine liniment, Divided into high and low concentration dose, and smear in the back surface of the skin. Observing, and recording the growth of hair in rats back. By measuring the content of serum androgens and Observing the skin HE dyeing slice, analyse the influence made on the hair growth and the morphological of hair follicle comprehensive. Results: Compared with model group, the hair and hair follicles of drug therapy group grow again and the effect of the treatment in high concentration is more significant than it in low concentration. Conclusion: he traditional Chinese medicine liniment has a therapeutic effect.

  6. Efficacy of local triamcinolone acetonide injection in combination with helium - neon laser irradiation in the treatment of alopecia areata%局部注射曲安奈德联合氦氖激光照射治疗斑秃的疗效观察

    Institute of Scientific and Technical Information of China (English)

    唐显华; 陈杏英; 梁敏仪

    2016-01-01

    目的:观察局部注射曲安奈德联合氦氖激光照射治疗斑秃的疗效。方法:将40例斑秃患者随机分成治疗组20例和对照组20例,治疗组局部注射曲安奈德基础上加用氦氖激光照射,对照组外涂糠酸莫米松软膏,两组治疗时间均为3个月。结果:治疗组总有效率85%,对照组总有效率40%,两组比较,差异有统计学意义(P <0.05)。结论:局部注射曲安奈德联合氦氖激光照射治疗斑秃有效率高,安全性好,值得临床推广。%Objective To observe the cilnical efficacy of local injection of triamcinolone acetonide in combination with helium - neon laser irradiation in the treatment of alopecia areata. Method 40 cases of alopecia areata patients were randomly di-vided into either a treatment group(20 cases)or a control group(20 cases). The treatment group were treated with helium - neon laser irradiation on the basis of local injection of triamcinolone acetonide while the control group were treated with mometasone fu-roate ointment. The course of treatment of the both groups for alopecia areata was three months. Results The total efficiency in the treatment group was 85% ,that was 40% in the other group. The difference between the two groups in effectiveness rate was statistically significant(P < 0. 05). Conclusion It is effective and safe for useing local injection of triamcinolone acetonide com-bined with irradiation of helium - neon laser to treat alopecia areata,which is worth for clinical promotion.

  7. Dermoscopic features of alopecia areata and their correlation with clinicopathological manifestations%斑秃皮损的皮肤镜影像及其与临床病理的关系

    Institute of Scientific and Technical Information of China (English)

    赵莹; 蔡泽明; 巩毓刚; 西兰; 杨建; 陈闻纳; 章星琪

    2011-01-01

    目的 探讨皮肤镜下斑秃皮损的微细改变及其与临床、病理相关性.方法 使用皮肤镜观察62例斑秃患者和44例其他类型脱发患者的皮损,收集患者临床及实验室资料,并对其中15例斑秃患者进行皮损部位组织病理活检,以了解皮肤镜的组织形态学基础.结果 皮肤镜下斑秃影像为黄点征、黑点征、断发、毳毛、新生短发和感叹号样毛发.黄点征发生率最高(83.9%),而诊断斑秃的特异性指标为感叹号样毛发、黑点和断发,且后三者发生率与斑秃的活动性及轻拉发试验阳性率呈显著正相关关系.甲状腺过氧化物酶抗体升高发生率与轻拉发实验阳性率及断发发生率呈显著正相关.黄点征发生率和病理下毛囊口角栓阳性率之间呈显著正相关关系,新生短发发生率和毛囊周围肥大细胞浸润发生率以及黑点发生率则与生长期与退行期毛囊之间比例减少均呈显著负相关关系.结论 可以用黄点征作为斑秃诊断的初筛指标,而感叹号样毛发、黑点和断发对于确诊斑秃的特异性较高,且提示患者病情仍处于活动期.斑秃患者皮肤镜影像与病理有一定相关性,可用于判断病情并指导治疗.%Objective To observe the microstructural changes in lesions of alopecia areata (AA) with dermoscopy and to evaluate their correlation with clinicopathological manifestations. Methods The area of alopecia of 62 patients with AA and 44 patients with other types of hair loss were observed by using a noncontact polarized dermoscope (Dermlite, USA). Clinical data on and laboratory findings from these patients were collected. Pathological examination was carried out with scalp biopsy specimens from the alopecia area of 15 AA patients. Results Characteristic dermoscopic signs of AA included yellow dots, black dots, broken hairs, exclamation mark hairs, short vellus hair and newly-grown short hairs. Among these signs, yellow dots showed the

  8. Clinical efficacy of low-level laser therapy for androgenetic alopecia%低能量激光治疗雄激素性秃发的临床疗效研究

    Institute of Scientific and Technical Information of China (English)

    程海艳; 禚风麟; 赵俊英

    2016-01-01

    Objective To evaluate the efficacy and safety of low⁃level laser therapy(LLLT)for androgenetic alopecia, and to compare the therapeutic effect of LLLT alone versus in combination with finasteride tablets. Methods Thirty⁃nine male patients were randomly divided into the LLLT group(n=21)and combination group(n=18)to be treated with LLLT alone or in combination with oral finasteride tablets(1 mg/d)for 6 months. LLLT was given twice a week, and each session lasted 30 minutes. All the patients were photographed and asked to fill a questionnaire about subjective symptoms, and hair density (the number of hairs per unit area on the scalp) was determined by using a dermatoscope to evaluate the grade of alopecia, before the treatment, and 3 and 6 months after the treatment. Results The hair density in the LLLT group was significantly higher after 6 months than after 3 months of treatment and before the treatment(184.59 ± 21.17 vs. 169.24 ± 29.21 and 166.67 ± 32.94 hairs/cm2, both P 0.05). The hair density in the combination group significantly increased after 6 and 3 months of treatment compared with that before the treatment(201.80 ± 16.55 and 186.39 ± 17.97 vs. 157.85 ± 27.97 hairs/cm2, both P 0.05), but the combination group showed increased hair density compared with the LLLT group after 3 and 6 months of treatment(both P 0.05). During the treatment, 24(62%)patients felt less greasy, and 22(56%)reported less hair loss, with no discomforts reported by the patients except local warm feeling. Conclusion LLLT is indeed effective for the treatment of androgenetic alopecia with no adverse reactions.%目的:评价低能量激光治疗雄激素性秃发的有效性及安全性,比较单纯低能量激光与低能量激光联合非那雄胺片治疗雄激素性秃发的疗效。方法39例男性雄激素性秃发患者随机分为低能量激光组和联合治疗组,治疗时间均为6个月。低能量激光组21例,单独使用低能量激光治疗,每周2

  9. 中西药综合治疗斑秃临床疗效观察%Clinical Efficacy of Combination of Traditional Chinese and Western Medicine on Treating Alopecia Areata

    Institute of Scientific and Technical Information of China (English)

    杜丹

    2012-01-01

    目的 观察中西药联合治疗斑秃的临床疗效.方法 将80例患者随机分为2组,治疗组40例采用口服胱氨酸片、复方甘草酸苷片、活力舒口服液及配合外擦中药复方当归生发酊;对照组40例,仅口服相同剂量的胱氨酸片、复方甘草酸苷片.治疗2个月后分析对比2组患者临床疗效 .结果 治疗组总有效率为95.0%,明显高于对照组的75.0%,2组比较差异有统计学意义(P<0.05).结论 中西药联合口服及外擦治疗斑秃比单纯的西药口服治疗效果好.%Objective To investigate the effect oi combination of traditional Chinese and western medicine on treating alopecia areata( AA ). Methods 80 AA patients were divided into two groups randomly. The patients in treatment group were treated by cystine tablet(50 mg tid p.o), compound of glycyrrbizic acid (75 ing tid p.o), vigor comfortable oral liquid ( 10 mL qn p.o), compound angelica breed-hair tincture (painted on the bald skin q4h/d) for two months. And patients in treatment group were treated with cystine tablet(50 mg tid p.o), compound of glycyrrhizic acid(75 mg tid p.o) for two months. Results The effective rate was 95.0% in the treatment group, and 75.0% in the control group. The difference between these two groups was significant (P<0.05 ). Conclusion The effect of combination of traditional Chinese and western medicine treatment of AA is better than taking western medicine only.

  10. 复方甘草酸苷对斑秃患者外周血单一核细胞中y干扰素、肿瘤坏死因子β表达的调节作用%Regulatory effect of glycyrrhizin on the expression of interferon (IFN)-γ and tumor necrosis factor (TNF)-β in peripheral blood mononuclear cells of patients with alopecia areata

    Institute of Scientific and Technical Information of China (English)

    秦小卫; 陈丽芳

    2011-01-01

    目的 探讨甘草酸苷对斑秃患者外周血单一核细胞(PBMC)γ干扰素(IFN-γ)、肿瘤坏死因子β(TNF-β)表达的调节作用.方法 轻度斑秃患者18例、重症斑秃患者24例及正常人20例为检测对象,用密度梯度离心法常规分离PBMC,用逆转录-聚合酶链反应检测PBMC经植物血凝素和复方甘草酸苷共同刺激后IFN-γ和TNF-β的表达水平.结果 重症斑秃组患者IFN-γ及TNF-β水平均明显高于轻度斑秃组及正常人对照组(P值均< 0.05),轻度斑秃组高于正常人对照组(P值均<0.05).甘草酸苷与植物血凝素共同刺激斑秃患者PBMC后可下调IFN--γ及TNF-β表达水平(P值均<0.05).结论 甘草酸苷可抑制斑秃患者Th1型细胞因子表达,逆转Th1型反应.%Objective To observe the regulatory effect of glycyrrhizin on the expression of IFN-γ and TNF-β in peripheral blood mononuclear cells (PBMCs) of patients with alopecia areata.Methods PBMCs were obtained from 18 patients with mild alopecia areata,24 patients with severe alopecia areata and 20 normal human controls,and cultured with phytohemagglutinin (PHA) or the combination of PHA and glycyrrhizin for 24 hours.Then,reverse transcription (RT)-PCR was conducted to detect the mRNA expression of IFN-γand TNF-β in these cells.Results The mRNA expression levels of IFN-γand TNF-β in PBMCs were significantly higher in patients with severe alopecia areata than in those with mild alopecia areata and normal human controls (all P < 0.05),and higher in patients with mild alopecia areata than in normal human controls (both P < 0.05).A significant decrease was observed in the mRNA expressions of IFN-γ and TNF-β in the PBMCs from patients with alopecia areata after stimulation with the combination of PHA and glycyrrhizin (both P <0.05).Conclusion Glycyrrhizin can inhibit the expression of Th1-type cytokines and reverse Th1-type immune response.

  11. Relationship between vitamin D receptor gene FokI polymorphism and alopecia areata in Inner Mon-golian Han population%内蒙古汉族人群维生素D受体FokI基因多态性与斑秃的关系

    Institute of Scientific and Technical Information of China (English)

    卓纳; 张满; 辛燕

    2015-01-01

    Objective:To determine the relationship between the polymorphism of vitamin D receptor gene FokI and alopecia areata in Inner Mongolia Han population. Methods:The polymorphism of vitamin D recep-tor Gene FokI sites in patients with alopecia areata (105 patients) and healthy controls (145 patients) were detected by PCR-RELP. Results:The genotype frequencies of FF, Ff and ff in patients were 0.324, 0.524, 0.152 and those in healthy controls were 0.297, 0.531, 0.172. There were no significant difference between the patients and the controls (P>0.05). Conclusion: There is no relationship between the polymorphism of vitamin D receptor FokI and alopecia areata in Inner Mongolia Han population.%目的::明确维生素D受体FokI基因多态性与内蒙古汉族人群斑秃的相关性。方法:运用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)技术,检测105例斑秃患者与145名健康对照的维生素D受体基因FokI酶切位点的多态性。结果:病例组维生素D受体FokI的3种基因型FF、Ff、ff频率分别为0.324、0.524、0.152,对照组分别为0.297、0.531、0.172,两组间比较无显著性差异( P>0.05)。结论:维生素D受体FokI基因多态性可能与内蒙古汉族人群斑秃的发病无关。

  12. Clinical effects of Meihua acupuncture plus the Huoxue Shengfa decoction on alopecia areata%梅花针叩击联合活血生发汤治疗气滞血瘀型斑秃的临床效果探究

    Institute of Scientific and Technical Information of China (English)

    程甘露

    2015-01-01

    Objective: To discuss clinical effects of Meihua acupuncture plus the Huoxie Shengfa decoction on alopecia areata. Methods:62 cases of outpatient with alopecia areata were randomly divided into the treatment group and the control group. The treated group received Meihua acupuncture plus the Huoxue Shengfa decoction. The control group received Meihua acupuncture plus Compound Glycyrrhizin. The efficacy and adverse reactions in two groups were observed. Results:The efficiency was 90.32%. The recurrence was 9.67%, adverse reactions in 1 cases. Two sets of efficacy and the adverse were compared, P<0.05. Conclusion:Meihua acupuncture plus the Huoxue Shengfa decoction for alopecia areata is safe and effective.%目的:探索梅花针叩击联合活血生发汤治疗气滞血瘀型斑秃的临床效果。方法:将皮肤科门诊62例斑秃患者随机分为治疗组和对照组,治疗组采用梅花针叩击联合活血生发汤(当归、丹参、郁金、赤芍、凌霄花、天麻、何首乌、乌梢蛇、甘草)治疗;对照组采用梅花针联合复方甘草酸苷片治疗,观察两组的疗效与不良反应。结果:治疗组治愈率为90.32%,复发率为9.68%,不良反应1例。对照组治愈率为67.74%,复发率为32.26%,不良反应6例。两组治愈率和不良反应比较,P<0.05。结论:采用梅花针点刺联合活血生发汤治疗斑秃安全有效。

  13. 复方甘草酸苷联合曲安奈德皮损内注射和液氮冷冻治疗斑秃的疗效%Efficacy observation on compound glycyrrhizin combined with intralesional injection with triamcinolone and cryotherapy with liquid nitrogen in the treatment of alopecia areata

    Institute of Scientific and Technical Information of China (English)

    梁国雄; 余嘉明; 王俊秀; 胡宝婵

    2012-01-01

    Objective To observe the clinical efficacy of compound glycyrrhizin combined with intralesional injection with triamcinolone and cryotherapy with liquid nitrogen in the treatment of alopecia areata. Methods 120 patients with alopecia areata were randomly divided into treatment group (n = 60) and control group (n = 60). All patients were accepted intralesional injection with triamcinolone suspension and cryotherapy with liquid nitrogen. The patients of treatment group were added to take compound glycyrrhizin orally. The total period of treatment was 8 weeks. The hair growth of lesions and adverse reaction was observed and recorded every 2 weeks, for 12 weeks in all. Results The cure rate(70.00%)and effective rate(90.00%)of treatment group was higher than that of control group. The effective rate of treatment group was continuously higher than that of control group after treating for 4 weeks. All the difference had statistical significance (P<0.05). Conclusion For treating alopecia areata, compound glycyrrhizin combined with intralesional injection with triamcinolone and cryotherapy with liquid nitrogen has the advantages of evident efficacy, short treating period and high safety. It is worthy of clinical popular application.%目的:观察复方甘草酸苷联合曲安奈德皮损内注射和液氮冷冻治疗斑秃的临床疗效.方法:将120例斑秃患者随机分为治疗组(n=60)和对照组(n=60),全部给予曲安奈德混悬液皮损内注射和液氮冷冻治疗,治疗组加口服复方甘草酸苷片.总疗程为8周,每2周观察和记录皮损内头发生长情况和不良反应,共观察12周.结果:治疗组的痊愈率(70.00%)和有效率(90.00%)均优于对照组,治疗4周后治疗组的有效率一直优于对照组,且差异都有统计学意义(P<0.05).结论:复方甘草酸苷联合曲安奈德皮损内注射和液氮冷冻治疗斑秃,疗效显著且疗程短,安全性高,值得临床推广应用.

  14. Causes of diffuse alopecia in women

    Directory of Open Access Journals (Sweden)

    Rustom Aziza

    1994-01-01

    Full Text Available Fifty female patients ranging in age between 14-45 years, complaining of a diffuse loss of hair for periods varying from 1-22 months were thoroughly interrogated to look for the factors leading to the hair loss. Laboratory investigations undertaken included a routine estimation of haemoglobin, ESR, urinalysis, examination of the stools, and any other test indicated by the history or examination. The hair loss was quantitated by asking the patient to collect all the fallen hairs during a 24 hours period for 7 consecutive days, and pack them into appropriately labelled polythene bags. Each collection was weighed to calculated the average daily loss. Such collections were repeated once a month for a period of 4-5 months to monitor the variations in the hair loss and study the effect for treatment. Ten hairs randomly picked from each collection were examined microscopically to look for any shaft abnormalities in addition to the examination of the root end and the distal end. The probable causes of hair loss in these patients were found to be psychologic stress in 21 cases, fever in 11 cases, child-birth/abortion in 5 cases, and a surgical operation in 3 cases. Some of these cases had more than one factor, while in 15 cases there was no clinical evidence of any of the known causes of hair loss. Routine laboratory investigations however revealed a haemoglobin level of less than 12 gm% in 25 cases, an ESR higher than 20 mm in 18 cases, asymptomatic urinary tract infection in 13 cases and gastro-intestinal parasites in stools in 12 cases. Thus every patient had at least one of the causative factors, while several patients had more than one factor which could be responsible for the hair loss. Almost all the cases in this group seemed to have telogen effluvium. Examination of the root end in most of the hairs showed a club hair, while the hair shaft revealed trichorrhexis in some of the hairs in 10 cases and trichoptilosis in 3 cases. Appropriate treatment normalised the hair loss which reflected in the collections of the fallen hair.

  15. Understanding and management of female pattern alopecia.

    Science.gov (United States)

    Leavitt, Matt

    2008-11-01

    Female pattern hair loss is devastating to many of the 21 million U.S. women who suffer from it. It is essential to differentiate female pattern hair loss from other types of hair loss to ensure appropriate treatment. Through use of follicular units, follicular families, and follicular pairing between existing hair follicles, natural-looking results can be achieved in women. Hair transplants create the benefit of increasing density and providing options for hair styling and can be combined with medications, devices, and styling aids such as minoxidil, low-level laser therapy, and topical powder makeup, respectively.

  16. Lipossomas de minoxidil para tratamento tópico da alopecia androgênica: desenvolvimento, caracterização e avaliação da permeação cutânea in vitro e in vivo

    OpenAIRE

    Barbosa, Círia Vieira

    2015-01-01

    A alopecia androgênica (AGA) é a mais comum das doenças crônicas dermatológicas e, entre os tratamentos utilizados para esta disfunção, o minoxidil (MNX) a 2% e 5% em soluções hidroalcoólicas tópicas apresenta sintomas relacionados à absorção sistêmica do fármaco, irritação do couro cabeludo devido ao álcool contido na formulação e retorno dos sintomas após interrupção do tratamento. O objetivo deste trabalho foi preparar, caracterizar e avaliar o perfil de liberação, a rete...

  17. Prevalence of androgenetic alopecia in a community of Shanghai: a survey%上海某社区雄激素源性秃发患病率调查

    Institute of Scientific and Technical Information of China (English)

    徐峰; 沈晔; 蔡伟俊; 蔡民强; 沈斌杰; 盛友渔; 楼玮; 周静; 任永涛; 齐思思; 杨勤萍; 王侠生; 付朝伟

    2008-01-01

    目的 了解上海地区雄激素源性秃发(AGA)的患病率、脱发类型.方法 采用整群抽样的方法.按照统一制定的表格,对上海市长宁区北新泾社区居民进行问卷调查,并由皮肤科医生进行诊断确认,对雄激素源性秃发患者采用Norwood-Hamilton和Ludwig标准分级.所有数据录入EpiData数据库,运用SPSS11.5软件进行统计学分析.结果 本次调查回收有效问卷7056份(男3519份,女3537份),应答率72.5%.确诊AGA患者809例,其中男701例,平均年龄(64.16±11.98)岁,年龄范围19~91岁,女108例,平均年龄(70.46±18.89)岁,年龄范围35~91岁.总标化患病率为9.47%,男性和女性标化患病率分别为15.73%和2.73%,两者间差异有统计学意义(χ2=356.00,P<0.001).52.7%的患者有AGA家族史,其中男为55.78%,女为32.41%.男性AGA患者70岁以上年龄脱发类型以Ⅵ级最多,而20~70岁年龄脱发类型以Ⅲv级最多.女性AGA脱发类型以Ⅰ级和Ⅱ级最多.结论 上海地区男性雄激素源性秃发患病率显著高于女性,男性和女性雄激素源性秃发的患病率随年龄增长而增加.%Objective To investigate the prevalence and pattern of androgenetic alopecia (AGA) in Shanghai through a community-based survey. Methods A cluster sampling survey was done among the residents in Beixinjing Community, Changning District, Shanghai. All the subjects were asked to fill a questionnaire to provide their general information, including sex, age, native place, physical status, life habit, family history, etc. The diagnosis of AGA was made by dermatologists. To determine the pattern of hair loss,Norwood-Hamilton classification system and Ludwig classification system were used for male AGA and female AGA, respectively. All the data were statistically analyzed by EpiData and SPSS11.5 software. Results Totally, 7056 subjects completed the questionnaire, including 3519 males and 3537 females, and the response rate was 72.5%. AGA was diagnosed in 809

  18. Clinical effect of Compound Betamethasone and Triamcinolone Acetonide Acetate in treating alopecia areata by local injection%局部注射复方倍他米松和醋酸曲安奈德治疗斑秃的疗效观察

    Institute of Scientific and Technical Information of China (English)

    尹伟欣; 李旭阳; 尹光文; 秦玉翰

    2012-01-01

    目的 比较局部注射复方倍他米松注射液和醋酸曲安奈德注射液治疗斑秃的临床疗效及不良反应.方法 182例斑秃患者随机分为治疗组和对照组各91例,治疗组采用复方倍他米松注射液1ml加2%利多卡因2ml,0.2ml/cm2局部注射,每4周1次,连续3次,对照组采用醋酸曲安奈德注射液1ml加2%利多卡因2ml,0.2ml/cm2局部注射,每周1次,连续3周,治疗组和对照组均同时口服维生素B6片(20mg,3次/d),谷维素片(20mg,3次/d),分别观察治疗后第4、8、12周的临床疗效及不良反应.结果 治疗第4周时治疗组和对照组有效率分别为17.58%和30.77%,P<0.05;第8周时治疗组和对照组有效率分别为46.15%和53.85%,P>0.05;第12周时治疗组和对照组有效率分别为83.52%和70.33%,P<0.05.结论 局部注射糖皮质激素治疗斑秃疗效确切,早期醋酸曲安奈德组疗效高于复方倍他米松组,但后期复方倍他米松组疗效高于醋酸曲安奈德组.%Objective To compare the clinical potency and untoward reactions of compound betamethasone and triamcinolone acetonide acetate in treating alopecia areata by local injection. Methods Totally 182 patients with alopecia areata were randomly divided into treatment group (n = 91) and control group ( n = 91) , using compound betamethasone ( 1 ml and 2ml of 2% lidocaine, 0.2ml/cm2) for treatment group by local injection, once per 4 weeks for 3 times directly. The control group were locally injected with triamcinolone acetonide acetate (1ml and 2ml of 2% lidocaine, 0. 2ml/cm2) , once a week for 3 times directly, then observed the clinical potency and untoward reactions at 4th.,8th., 12th weeks respectively. All the patients were received VitaminB6 20 mg and oryzanol 20 mg, po, tid. Results At the 4th week, the effective power of treatment group and control group was 17. 58% and 30.77% (P >0.05) , significant differences were found among the tow groups. At the 8th week, the effective

  19. The proliferation and apoptosis of hair follicle stem cells in hair follicle in male patients with androgentic alopecia%男性雄激素源性脱发患者毛囊干细胞增殖和凋亡的初步研究

    Institute of Scientific and Technical Information of China (English)

    董佳辉; 万苗坚; 冯智英; 李英; 李晓欣; 龚子鉴; 赖维; 计斌

    2012-01-01

    Objective To investigate the proliferation and apoptosis of hair follicle stem cells in male patients with AGA.Methods The follicle from different scalp areas (occipital of non-hair loss, hair loss transition and hair loss zone ) of 15AGA patients and 3 normal scalp. Using double immunofluorescence method to study the proliferation and apoptosis ofhair follicle stem cell in scalp different regions. Results In hair follicle bulge area of normal group and patients' occipitalarea,there is no significant difference between the percentage of PCNA-positive cells in CK15 positive cells (P>0.05),they both are higher than that of the hair loss area and the hair loss transition area (P <0.05). There are no TUNELpositivecells in the CK15-positive cells in each group, TUNEL-positive cells are mainly distributed in the inner hairfollicle root sheath, The rate of TUNEL -positive cells is no significant difference among the groups (P >0.05).Conclusion Decrease of the proliferation activity of the hair follicle stem cells may be involved in the pathogenesis ofmale patients with AGA.%目的:了解男性雄激素源性脱发(androgenetic alopecia,AGA)患者毛囊干细胞增殖和凋亡情况.方法:对来自15例男性AGA患者和3例正常人的头皮,采用双重免疫荧光的的方法检测毛囊干细胞增殖和凋亡.结果:CK15标记的毛囊干细胞中增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)阳性细胞率由高到低依次为:正常对照组、患者枕部、脱发过渡区和脱发区,除脱发过渡区与脱发区间比较无显著性差异(P>0.05)外,其它各组间比较,均有显著性差异(P<0.05).各组毛囊中CK15阳性的细胞中均无TUNEL阳性细胞,TUNEL阳性细胞主要分布于内毛根鞘,总的TUNEL阳性细胞率在各组间无明显差异(P均>0.05).结论:毛囊干细胞增殖活性下降可能参与男性AGA的脱发过程.

  20. 甘草酸苷联合卤米松乳膏和氦氖激光照射治疗斑秃对血清白三烯B4、白三烯C4、C反应蛋白和白介素-10的影响%The effect of serum leukotriene B4,leukotriene C4,C-reactive protein and interleukin-10 after treatment alopecia areata by glycyrrhizin combined with halometasone cream and He-Ne laser

    Institute of Scientific and Technical Information of China (English)

    张玉刚; 杨秀凤

    2015-01-01

    目的:研究甘草酸苷联合卤米松乳膏和氦氖激光照射治疗斑秃及治疗前后患者外周静脉血清白三烯B4、白三烯C4、C反应蛋白和白介素-10的变化,为临床有效治疗斑秃提供科学依据。方法:2013年2月-2014年8月,采用复方甘草酸苷片(日本米诺发源制药株式会社研制生产)联合卤米松乳膏(上海通用药业有限公司生产)局部涂抹和氦氖激光照射治疗斑秃。3个月后评价疗效并采用ELISA法检测患者血清白三烯B4、白三烯C4、C反应蛋白和白介素-10的水平。结果:卤米松乳膏组、卤米松乳膏激光组和联合治疗组有效率分别为70%、82.5%,97.5%。联合治疗组疗效优于卤米松乳膏组和卤米松乳膏激光组,三组间差异均有统计学意义(χ2分别为9.95和4.31,P<0.05)。联合治疗组白三烯B4、白三烯C4、C反应蛋白和白介素-10水平较卤米松乳膏组和卤米松激光组明显降低(P<0.05)。结论:复方甘草酸苷联合卤米松乳膏和局部激光照组射治疗斑秃,可以达到调节患者的自身免疫力,改善斑秃皮损部位血液微循环,增加毛囊的供血、供氧,有效提高斑秃的治愈率,并且无明显严重不良反应,是皮肤科临床治疗斑秃的有效手段之一,非常值得在基层医院皮肤科推广。%Objective Study on glycyrrhizic acid glycosides joint halide halometasone cream and He-Ne laser irradiation treatment of alopecia areata and before and after treatment in patients with peripheral venous serum leukotriene B4,leukotriene C4,C- reactive protein and the changes of interleukin- 10,provide scientific basis for clinical effective in the treatment of alopecia areata. Methods From February 2013 to August 2014,adopting compound glycyrrhizin glucoside piece (Japan mino originated,developed and produced by pharmaceutical Co.,LTD)joint halide halometasone cream (Shanghai general pharmaceutical Co

  1. Alopecia associated with unexpected leakage from electron cone

    Energy Technology Data Exchange (ETDEWEB)

    Wen, B.C.; Pennington, E.C.; Hussey, D.H.; Jani, S.K.

    1989-06-01

    Excessive irradiation due to unexpected leakage was found on a patient receiving electron beam therapy. The cause of this leakage was analyzed and the amount of leakage was measured for different electron beam energies. The highest leakage occurred with a 6 x 6 cm cone using a 12 MeV electron beam. The leakage dose measured along the side of the cone could be as great as 40%. Until the cones are modified or redesigned, it is advised that all patient setups be carefully reviewed to assure that no significant patient areas are in the side scatter region.

  2. The frequency distribution of celiac autoantibodies in alopecia areata

    Directory of Open Access Journals (Sweden)

    Fatemeh Mokhtari

    2016-01-01

    Conclusions: There may be a relationship between CD and AA, but the absence of statistical association between AA and CD does not mean that there is no relationship between gluten and AA in certain patients. Thus, we have shown here that the biological tests to search for CD do not bring information and proof enough, and it is why we recommend another approach to disclose gluten intolerance in AA patients.

  3. Selected Disorders of Skin Appendages--Acne, Alopecia, Hyperhidrosis.

    Science.gov (United States)

    Vary, Jay C

    2015-11-01

    This article reviewed some of the more common diseases of the skin appendages that are encountered in medicine: hyperhidrosis, acne, AA, FPHL, AGA, and TE. The pathophysiology behind the conditions and their treatments were discussed so that the clinician can make logical therapeutic choices for their affected patients.

  4. 斑秃皮损内朗格汉斯细胞及CD8+T细胞的数量及分布分析%Quantity and distribution of Langerhans cells and CD8 + T cells in lesions of alopecia areata

    Institute of Scientific and Technical Information of China (English)

    张小婷; 李水凤; 赵莹; 叶艳婷; 戚世玲; 杨雨清; 曹慧; 章星琪

    2014-01-01

    Objective To analyze the quantity and distribution of Langerhans cells in lesions of alopecia areata (AA),so as to investigate their role in the pathological process of AA as well as their relationship with T lymphocytes.Methods Tissue specimens were obtained from the scalp lesions of AA in 29 patients,including 16 in active phase and 13 in non-active phase.All the specimens were subjected to immunohistochemical staining for CD1a,and 17 specimens to immunohistochemical staining for CD4 and CD8.Fluorescence-based semi-quantitative reverse transcription (RT)-PCR was performed to determine the mRNA expressions of CD1a and granulocytemacrophage colony stimulating factor (GM-CSF) in the full-thickness skin specimens.Statistical analysis was done using Mann Whitney U test and Pearson correlation analysis.Results There was a significant increase in the quantity of CD1a+ Langerhans cells in the epidermis,perivascular and perifollicular areas in the upper and deep dermis of the AA patients compared with the healthy controls (Z =4.354,2.884,4.640,3.217,3.496,all P < 0.01),and in the epidermis,perivascular and perifollicular areas in the deep dermis of AA patients in active phase compared with those in non-active phase (Z =2.457,2.130,1.954,P < 0.05 or =0.05).The relative mRNA expression levels of CD1a and GM-CSF in the patients were similar to the healthy controls in the upper dermis,but significandy higher than the healthy controls in the deep dermis (Z =2.702,2.941,both P < 0.01).A positive correlation was observed between the quantity of perivascular Langerhans cells in the upper dermis and that of perifollicular CD8+ T lymphocytes in the deep dermis in patients with AA (r =0.618,P < 0.05) and in patients with active AA (r =0.795,P =0.01),but not in patients with inactive AA (r =0.304,P > 0.05).Conclusions The number of Langerhans cells is elevated in patients with AA,especially in patients with active AA.The quantity of perivascular Langerhans cells in the

  5. Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention.

    Science.gov (United States)

    Choi, Jae-Suk; Jung, Sung Kyu; Jeon, Min-Hee; Moon, Jin-Nam; Moon, Woi-Sook; Ji, Yi-Hwa; Choi, In Soon; Wook Son, Sang

    2013-01-01

    To evaluate the potential hair growth-promoting activity and the expression of cell growth factors of Lycopersicon esculentum extracts, each 3% (w/w) of ethyl acetate extract (EAE), and supercritical CO2 extract (SCE) of L. esculentum and isolated lycopene Tween 80 solution (LTS) and test hair tonic (THT) containing LTS were applied on the dorsal skin of C57BL/6 mice, once a day for 4 weeks. At week 4, LTS and THT exhibited hair growth-promoting potential similar to that of 3% minoxidil as a positive control (PC). Further, in the LTS group, a significant increase of mRNA expression of vascular endothelial growth factor (VEGF), keratinocyte growth factor, and insulin-like growth factor-1 (IGF-1) was observed than PC, as well as the negative control (NC). In the THT group, increases in IGF-1 and decrease in VEGF and transforming growth factor-β expression were significant over the NC. In a histological examination in the THT group, the induction of anagen stage of hair follicles was faster than that of NC. In the Draize skin irritation study for THT, no observable edema or erythema was observed on all four sectors in the back skin after exposure for 24 or 72 h for any rabbit. Therefore, this study provides reasonable evidence that L. esculentum extracts promote hair growth and suggests that applications could be found in hair loss treatments without skin irritation at moderate doses.

  6. Specific cutaneous histologic and immunologic features in a case of early lupus erythematosus scarring alopecia

    Directory of Open Access Journals (Sweden)

    Ana Maria Abreu Velez

    2013-04-01

    Full Text Available Introduction:Immunoreactants detected by direct immunofluorescence (DIF in the skin of patients with lupus erythematosus represent an important tool in the diagnosis of this disorder. Case report: A 46 year old African American female presented complaining of hair loss and scarring in her scalp.Methods: Biopsies for hematoxylin and eosin (H&E examination, as well as for direct immunofluorescence (DIF were performed.Results: The histologic features were representative of early lupus erythematosus. DIF demonstrated immune deposits of several immunoglobulins and complement, primarily around skin appendageal structures(hair follicles and sweat glands. Deposits of immunoglobulin D were seen in several areas of the epidermis.Conclusion: In lupus erythematosus, evaluation of immune reactions against cutaneous appendageal structures may be crucial in differentiating this disorder from other autoimmune and non-autoimmune diseases.

  7. Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness

    DEFF Research Database (Denmark)

    Marcińska, Magdalena; Pośpiech, Ewelina; Abidi, Sarah;

    2015-01-01

    and an extended 20-SNP model were developed based on a discovery panel of 305 males from various European populations fitting one of two distinct phenotype categories. The first category consisted of men below 50 years of age with significant baldness and the second; men aged 50 years or older lacking baldness...

  8. 汞中毒伴脱发1例报告%A case of mercury poisoning with alopecia

    Institute of Scientific and Technical Information of China (English)

    张海东; 温秀云

    2008-01-01

    @@ 1 病例介绍 患者,女,39岁,无业,因服用含汞"秘方"一个半月,头发全秃入院.该患间断皮肤瘙痒,偶伴红丘疹两月余,经人介绍服用治牛皮癣"秘方",一个月后头发成束脱落伴低热、头痛、恶心、腹泻、口腔溃疡,再服半月头发全秃,停药.医疗纠纷2个月经法律部门检验"秘方"为汞制剂(何种汞与量不详),不含铊,经介绍来我院治疗.患者既往健康,期间无服用其他药物史.

  9. Alopecia in association with lamotrigine use : an analysis of individual case safety reports in a global database

    NARCIS (Netherlands)

    Tengstrand, Maria; Star, Kristina; van Puijenbroek, Eugène P; Hill, Richard

    2010-01-01

    BACKGROUND: The WHO Programme for International Drug Monitoring, maintained by the Uppsala Monitoring Centre (UMC), has more than 90 member countries contributing individual case safety reports (ICSRs) from their existing national pharmacovigilance systems; these reports are stored in the WHO global

  10. Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia

    OpenAIRE

    Chen, Chih-Chiang; Chuong, Cheng Ming

    2012-01-01

    Stem cells are fascinating because of their potential in regenerative medicine. Stem cell homeostasis has been thought to be mainly regulated by signals from their adjacent micro-environment named the “stem cell niche”. However, recent studies reveal that there can be multiple layers of environmental controls. Here we review these environmental controls using the paradigm of hair stem cells, because to observe and analyze the growth of hair is easier due to their characteristic cyclic regener...

  11. Lipid nanoparticles for topical and transdermal application for alopecia treatment: development, physicochemical characterization, and in vitro release and penetration studies

    DEFF Research Database (Denmark)

    Gomes, M. J.; Martins, S.; Ferreira, D.

    2014-01-01

    less than 30% was achieved for minoxidil nanoparticles, over 28 days. Controlled release assays in physiological conditions demonstrated that nanoparticles loaded with minoxidil yielded a prolonged release, as desired. Penetration assays through pig ear skin demonstrated that nanoparticles loaded...... and finasteride) into the dermis and hair follicles. Lipid nanoparticles, prepared by ultrasonication method, showed mean particle sizes around 200 nm, which is sufficient for reaching the dermis and hair follicles, and zeta potential values around -30 mV, which indicates good physical stability. Over 28 days...... of storage, no significant variations in these parameters were observed, which indicates that all nanoformulations are stable in storage over that period. Cryo-scanning electron microscope measurements showed that all the lipid nanoparticles exhibited a spherical shape and a smooth surface regardless...

  12. Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia.

    Science.gov (United States)

    Chen, Chih-Chiang; Chuong, Cheng Ming

    2012-04-01

    Stem cells are fascinating because of their potential in regenerative medicine. Stem cell homeostasis has been thought to be mainly regulated by signals from their adjacent micro-environment named the "stem cell niche". However, recent studies reveal that there can be multiple layers of environmental controls. Here we review these environmental controls using the paradigm of hair stem cells, because to observe and analyze the growth of hair is easier due to their characteristic cyclic regeneration pattern. The length of hair fibers is regulated by the duration of the growth period. In the hair follicles, hair stem cells located in the follicle bulge interact with signals from the dermal papilla. Outside of the follicle, activation of hair stem cells has been shown to be modulated by molecules released from the intra-dermal adipose tissue as well as body hormone status, immune function, neural activities, and aging. The general physiological status of an individual is further influenced by circadian rhythms and changing seasons. The interactive networks of these environmental factors provide new understanding on how stem cell homeostasis is regulated, inspiring new insights for regenerative medicine. Therapies do not necessarily have to be achieved by using stem cells themselves which may constitute a higher risk but by modulating stem cell activity through targeting one or multiple layers of their micro- and macro-environments.

  13. Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency

    NARCIS (Netherlands)

    Lemoine, Roxane; Pachlopnik-Schmid, Jana; Farin, Henner F; Bigorgne, Amélie; Debré, Marianne; Sepulveda, Fernando; Héritier, Sébastien; Lemale, Julie; Talbotec, Cécile; Rieux-Laucat, Frédéric; Ruemmele, Frank; Morali, Alain; Cathebras, Pascal; Nitschke, Patrick; Bole-Feysot, Christine; Blanche, Stéphane; Brousse, Nicole; Picard, Capucine; Clevers, Hans; Fischer, Alain; de Saint Basile, Geneviève

    2014-01-01

    BACKGROUND: Inflammatory bowel disease (IBD) is one of the most common chronic gastrointestinal diseases, but the underlying molecular mechanisms remain largely unknown. Studies of monogenic diseases can provide insight into the pathogenesis of IBD. OBJECTIVE: We thought to determine the underlying

  14. [A Case of Dengue Fever and Subsequent Long-lasting Depression Accompanied by Alopecia in a Japanese Traveler Returning from Bali, Indonesia].

    Science.gov (United States)

    Hitani, Akihiro; Yamaya, Waka; To, Masako; Kano, Ichino; Honda-Hosono, Natsue; Takasaki, Tomohiko; Haruki, Kosuke

    2015-03-01

    Recovery from dengue fever is generally rapid and uneventful. However, recuperation is often prolonged and may be accompanied by noticeable depression. We present herein on a traveler to Indonesia who developed long-lasting depression after the classic symptoms of dengue fever such as fever, arthralgia, and macropapular rash had resolved. A previously healthy 42-year old japanese woman presented to the Travel Clinic of Seirei Yokohama Hospital with complaints of 4 days of fever, joint aches, bone pain, and a macropapular rash on her torso. She had returned from Bali 5 days previously. During her 1-week stay, one day was spent in rural, mountainous areas where she was exposed to several mosquito bites. The 1st serum sample collected 4 days after the disease onset gave positive result in the rapid dengue IgM antibody test and the rapid dengue NS1 antigen immunechromatographic test. The DENV-1 genome was detected with RT-PCR. Her 13-year old son, who had accompanied her, was also diagnosed as having dengue fever and he recovered without event. The Above-mentioned symptoms resolved within one week. However, the patient suffered from prolonged depression. She also noticed loss of hair 3 months after the disease onset Administration of a Serotonin-Noradrenalin Reuptake Inhibitor and a minor tranquillizer required to allow her requied to lead a normal life. Although she gradually felt better, it took approximately 2 years until she had recovered completely without taking any antidepressant and minor tranquillizer. It is a well-known fact in endemic countries that dengue fever could have an significant impact on the patients' mental well-being. However, it appears that physicians in non-endemic countries are not fully aware of the prolonged depression, which can occur subsequent to the acute illness. Follow-up consultations of returing travelers who have recoverd from dengu fever should be arranged to monitor their mental and emotional states closely.

  15. 脂溢性脱发的中西医研究进展%Progression of seborrheic alopecia studied with integrated traditional Chinese and western medicine method

    Institute of Scientific and Technical Information of China (English)

    黎伟珍; 魏跃钢

    2004-01-01

    脂溢性脱发(seobrrheic alopecia,SA)简称脂脱,又名男性型秃发、雄激素源性秃发,中医称之为“发蛀脱发”、“蛀发癣”,临床多表现为头发油腻、多屑、有明显瘙痒感、额颞区及顶部的渐进性脱发,继而形成高额。此病是皮肤科的常见病、多发病,也是难治性疾病之一。由于本病影响美观,常给患者带来很大的精神压力和心理负担,因此对SA的研究受到广泛的重视,现综述如下。

  16. 脂溢性脱发的治疗研究进展%Advances on the treatment study of sebrrheic alopecia

    Institute of Scientific and Technical Information of China (English)

    席建元; 禤国维; 陈达灿

    2005-01-01

    脂溢性脱发(sebrrheic alopecia,SA)又称男性型秃发、雄性激素性秃发、弥散型秃发,是皮肤科常见病、多发病,也是难治性疾病之一。多见于20~30岁男性,好发于头顶及前额两侧;本病病因尚未完全明确,目前尚无较好的治疗方法,特别是生发较为困难,由于本病影响美观,常给患者带来很大的精神压力和心理负担,而随着人民生活水平的提高,对本病治疗的要求更为迫切。

  17. Female pattern baldness

    Science.gov (United States)

    Alopecia in women; Baldness - female; Hair loss in women; Androgenetic alopecia in women; Hereditary balding or thinning in women ... in the skin called a follicle. In general, baldness occurs when the hair follicle shrinks over time, ...

  18. Male pattern baldness

    Science.gov (United States)

    Alopecia in men; Baldness - male; Hair loss in men; Androgenetic alopecia ... Male pattern baldness is related to your genes and male sex hormones. It usually follows a pattern of receding hairline and ...

  19. Disease: H00621 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00621 Alopecia neurologic defects and endocrinopathy syndrome (ANE syndrome) Alope...cia neurological defects and endocrinopathy syndrome (ANE syndrome) is an autosomal recessive disease that i... R, Bindereif A, Choder M, Shalev S, Sprecher E Alopecia, neurological defects, and endocrinopathy syndrome

  20. Disease: H00682 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00682 Woodhouse-Sakati syndrome; Hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrap...rder that encompasses alopecia, hypogonadism, diabetes mellitus, mental retardation, and extrapyramidal sign...ng a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyrami

  1. Disease: H00906 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00906 Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome Macrocephal...y, alopecia, cutis laxa, and scoliosis is an autosomal-recessive disorder related to the cutis laxa group of...val hypertrophy, retrognathia with abnormal skull morphology, and severe scoliosis...haly, alopecia, cutis laxa, and scoliosis: MACS syndrome. Am J Hum Genet 85:254-6

  2. Construction of alopecia areata dermal papilla cDNA substractive library%应用抑制性消减杂交方法构建斑秃毛乳头差异表达基因文库

    Institute of Scientific and Technical Information of China (English)

    杨希川; 郝飞; 程波; 宋志强; 杨卫兵; 向明明

    2002-01-01

    目的构建斑秃区与正常毛囊毛乳头细胞(DPC)差异表达的cDNA正向和反向消减杂交文库,为从中克隆鉴定出斑秃特异性表达和生长期DPC特异性表达的基因奠定基础.方法应用抑制性消减杂交技术,分别从斑秃区DPC及正常头皮DPC提取总mRNA;依次合成单链及双链cDNA,分别与2种不同的接头连接,再进行正向和反向的2次消减杂交及2次抑制性PCR;将产物与T/A载体连接构建cDNA消减文库.结果构建成功具有高消减效率的斑秃区及正常头皮DPC cDNA消减文库,文库扩增后得到120个阳性克隆,其中90个克隆含有100~500 bp插入片段.结论应用抑制性消减杂交技术所构建的斑秃区及正常头皮DPC cDNA消减文库,为进一步批量筛选、克隆斑秃区及正常头皮DPC特异性表达的基因奠定了基础.

  3. 单根毛囊改良分离法在疤痕性秃发毛囊移植中的临床研究%Clinical research of improved single hair follicle isolation in scarring alopecia hair transplant

    Institute of Scientific and Technical Information of China (English)

    黄胜华; 胡志奇; 颜玲; 郭栋; 罗艳香; 石颖

    2011-01-01

    目的 采用改良的单根毛囊分离法得到单根完整毛囊,用于毛发移植治疗头部及眉部的疤痕性秃发,探讨该法应用于疤痕植发的技术要点和临床效果,为毛发移植治疗提供一定的临床数据.方法 头部和眉部疤痕性秃发17例患者,使用改良法获得单根毛囊并植入疤痕秃发区域.统计供区所得完整单根毛囊数和受区毛囊成活数,并在术中取所得毛囊进行组织学检查.结果 17例患者随访3~12个月,生长外观自然,原有疤痕基本遮盖.供区毛囊提取率为54.87%~86.01%,受区毛囊成活率为70.27%~96.36%,组织学检查显示毛囊生发结构完整.结论 改良分离法获取的单根完整毛囊具生长活性,植入后天获得性的疤痕秃发区域内后生长良好,可改善疤痕区外观.%Objective Applying improved method to isolate and collect the complete single hair follicles, for hair transplant in hair deficiency in head or eyebrow scar.Investigate the main point and effectiveness of this new method.Methods 17 cases of hair deficiency in head or eyebrow scar were treated with hair transplant, applying the new method to isolate and collect the single hair follicles from donor area and then transplant into the scar area.The number of complete hair follicles acquired from donor area and the survival transplanted follicle in recipient area was counted, and histological examination was carried out for the follicle acquired in donor area.Results 17 cases were followed up for 3-12 months, scar areas were almost covered and got natural appearance.The follicle extraction percentage was 54.87%-86.01% and the follicle survival rate was 70.27%-96.36%.The hair follicles growth architecture was complete in histological examination.Conclusion The improved method can get live complete single hair follicles, and the single hair follicles can grow well in the scar area and give good appearances.

  4. 养血生发汤治疗斑秃疗效观察%THE EFFECTIVE STUDY OF THE NUTRITION-BLOOD AND CULTURING-HAIR DECOCTION TREATING ALOPECIA AREATE

    Institute of Scientific and Technical Information of China (English)

    曹素芬

    2001-01-01

    目的:观察中药汤剂治疗斑秃的治疗效果.方法:采用养血生发汤治疗斑秃患者40例,同时与胱氨酸、VitE等治疗38例比较.结果:养血生发汤组的痊愈率、有效率分别于67.5%、87.5%;对照组的痊愈率、有效率分别为42.1%和68.4%,两者有明显差异(P<0.05,P<0.05).结论:养血发生汤是治疗斑秃的一个有效组方.

  5. Effect and Mechanism of Topical Contacts Sensitizer Therapy on Severe Alopecia Areata%接触致敏剂治疗重型斑秃疗效及作用机制

    Institute of Scientific and Technical Information of China (English)

    赵莹; 晁青; 陈海莲

    2014-01-01

    目的 探讨外用接触致敏剂二苯基环丙烯酮治疗重型斑秃的疗效.方法 对15例重型斑秃患者进行二苯基环丙烯酮治疗,详细记录其临床资料、治疗反应、副作用.ELISA检测正常对照组及治疗前、治疗后3个月患者血清细胞因子IFN-γ、IL-5水平.结果 有效率为60%,疗效与年龄、发病年龄、病程、维持治疗浓度、脱发面积、甲改变等无明显相关性.与正常对照组相比,15例斑秃患者血清IFN-y水平显著增高,IL-5水平显著降低(P<0.05).经3个月治疗后,斑秃患者血清IFN-y水平显著减低(P<0.05),与正常对照组相对持平(P=0.342).血清IL-5水平显著增高,但仍低于正常对照组(P<0.05).结论 二苯基环丙烯酮作为一种接触致敏剂,可能是通过引发了迟发型变态反应,降低Th1型细胞因子表达,改变了局部免疫反应类型,而使毛囊周期进入生长期,达到治疗目的.

  6. 8 Cases of Alopecia Areata Treated by External Therapy with Chinese Herbs Wine%外用中药酒治疗斑秃8例临床观察

    Institute of Scientific and Technical Information of China (English)

    靳毅; 吴玉山; 温秀珍; 李堃

    2004-01-01

    斑秃,俗称“鬼剃头”,为一种头部突然发生的局限性斑状秃发,其病因尚不完全清楚,有学者认为斑秃是自身免疫性疾病,亦有持否定态度者。遗传也可能是病因之一,而精神因素常是诱发及促使病情加重的原因,但也有部分病例找不到明显原因。中医理论则认为发为血之余,为肾之外华,如果肝肾亏虚,血精不足,毛发失养,则毛窍开张,而毛发脱落;亦可因血虚气弱,腠理不固,风邪乘虚而入,损伤毛孔,引起脱发;或因情志内伤,气机紊乱,血行不畅,阻滞经络;或因血热生风,风盛血燥,由于燥热损伤,毛发失养而脱落。而我们采用外用中药酒治疗斑秃8例,疗效尚可,现报道如下。

  7. 脱发疾病患者的精神心理问题及治疗措施%Mental and Psychological Problems and Therapeutic Measure of Patients with Alopecia

    Institute of Scientific and Technical Information of China (English)

    章星琪

    2016-01-01

    脱发疾病多为慢性和难治性疾病,且影响美容,导致心理问题.脱发疾病涉及精神心理范畴的主要有原发性心理疾患导致脱发如拔毛癖,以及继发于毛发疾病的心理情感应激如抑郁、焦虑和社交障碍等.精神因素可以作为脱发的主要病因、或为加重脱发的诱因之一、或继发于脱发疾病.因此,脱发疾病的治疗中不仅要用药物治疗,还要用心理治疗.本文着重分析脱发疾病领域中精神心理疾患的临床表现和处理,后者包括心理咨询、建立病人小组活动、定期随访和指导病人建立良性的应对策略等.

  8. Marked Reduction of the Number and Individual Volume of Sebaceous Glands in Psoriatic Lesions

    DEFF Research Database (Denmark)

    Liakou, Aikaterini I; Nyengaard, Jens R; Bonovas, Stefanos;

    2016-01-01

    and psoriatic alopecia. OBJECTIVE: The aim of this study was to investigate possible changes of the sebaceous glands in patients with psoriatic plaques and especially psoriatic alopecia. METHODS: Histological and stereological analyses were performed in skin specimens from involved and healthy-looking skin...... gland may be a player and not an innocent bystander in the development of psoriatic lesions and especially of psoriatic alopecia....

  9. Trichoscopy

    Directory of Open Access Journals (Sweden)

    Özlem Dicle

    2015-06-01

    Full Text Available Trichoscopy (hair and scalp dermoscopy is a valuable in vivo tool for the differential diagnosis of clinically frequent hair diseases. It is based on evaluation of basic structures that may be visualized with a dermascope; follicular openings, hair shafts and perifollicular epidermis. This method is useful to diagnose early androgenetic alopecia, to distinguish androgenetic alopecia from telogen effluvium, to make differential diagnosis of patchy alopecias and differentiate scarring from nonscarring alopecias. This article summarizes the current knowledge in abnormal appearances of basic structural components on trichoscopy and characteristic trichoscopic features of the most common hair diseases.

  10. Yoga-Based Rehabilitation Program in Reducing Physical and Emotional Side Effects in Patients With Cancer

    Science.gov (United States)

    2017-01-23

    Alopecia; Anxiety; Breast Carcinoma; Cognitive Side Effects of Cancer Therapy; Colorectal Carcinoma; Depression; Fatigue; Lung Carcinoma; Nausea and Vomiting; Pain; Psychological Impact of Cancer; Sleep Disorder; Weight Change

  11. Biotinidase Deficiency Accompanying Hair Changes and Periorificial Lesions: A Case Report

    Directory of Open Access Journals (Sweden)

    Sema Aytekin

    2011-11-01

    Full Text Available Biotinidase deficiency is impairment of biotin metabolism characterized by various dermatological, ophthalmic and neurological symptoms. Autosomal recessive trait is a disorder. Skin findings such as alopecia, periorificial dermatitis and seborrhoeic dermatitis lesions are seen. Clinical signs improved dramatically with biotine treatment. We presented a 6-year-old male patient with periorificial lesions, alopecia and microscopic hair shaft defects.

  12. Frontal fibroserende alopeci er en variant af lichen planopilaris

    DEFF Research Database (Denmark)

    Gameza, Vitaly A; Deleuran, Mette

    2015-01-01

    Frontal fibrosing alopecia is a scarring alopecia which typically affects the frontotemporal region of the scalp. Loss of hair in the other areas of the skin is present in the majority of cases. The condition is overrepresented among postmenopausal women, but men and premenopausal women can...

  13. [Forum on tissue expansion. Expansion of the scalp. Surgical techniques and clinical applications].

    Science.gov (United States)

    Foyatier, J L; Delay, E; Comparin, J P; Latarjet, J; Masson, C L

    1993-02-01

    Repair of all forms of alopecia is one of the principal applications of scalp expansion. The authors have inserted 400 expansion prostheses, including 20 in the scalp. The surgical technique, choice of material and various types of flaps are described and illustrated by clinical cases of extensive alopecia.

  14. Hair Loss Observed in Women and Iron Deficiency

    Directory of Open Access Journals (Sweden)

    Özlem Dicle

    2010-03-01

    Full Text Available Being a common state in the society, iron deficiency might lead to an increase in the dermatological problems associated with it. Alopecia is an important finding among the patients referring to dermatology clinics but studies on different types of alopecia and their relationship with iron deficiency states are controversial and the present data are not sufficient to draw definite conclusions.

  15. Folliculotropic mycosis fungoides: clinical and histologic features in five patients

    Directory of Open Access Journals (Sweden)

    Amir Hooshang Ehsani

    2016-01-01

    Full Text Available Background: Alopecia can be a manifestation of mycosis fungoides (MF; however, the prevalence is unknown. Aims: We sought to describe the clinicopathologic presentation of alopecia in patients with diagnosis of MF. Methods: A retrospective analysis of patients with biopsy-proven MF, who were evaluated at our cancer center from 2002 to 2012, was performed to identify patients with alopecia. Results: Five patients with alopecia were identified from reviewing of 157 patients with MF. The male:female ratio was 3:2, and the mean age of patients was 42.8 years. Two of these patients showed patchy hair loss on scalp which was clinically identical to alopecia areata. In remaining three patients, hair loss was seen in areas of MF lesions, and epidermal changes consisted of patch- and plaque-type lesions of MF, tumors, and follicular lesions (follicular MF were also present. In two of these patients, lymphadenopathy without any visceral involvement was detected. Conclusions: Alopecia was observed in 5 (3.18% patients with MF, which makes it a rare finding, which included alopecia areata-like patchy loss in 2 and alopecia within MF lesions in 3.

  16. Frontal fibroserende alopeci er en variant af lichen planopilaris

    DEFF Research Database (Denmark)

    Gameza, Vitaly A; Deleuran, Mette

    2015-01-01

    Frontal fibrosing alopecia is a scarring alopecia which typically affects the frontotemporal region of the scalp. Loss of hair in the other areas of the skin is present in the majority of cases. The condition is overrepresented among postmenopausal women, but men and premenopausal women can be af...

  17. Hair care and dyeing.

    Science.gov (United States)

    Draelos, Zoe Diana

    2015-01-01

    Alopecia can be effectively camouflaged or worsened through the use of hair care techniques and dyeing. Proper hair care, involving hair styling and the use of mild shampoos and body-building conditioners, can amplify thinning scalp hair; however, chemical processing, including hair dyeing, permanent waving, and hair straightening, can encourage further hair loss through breakage. Many patients suffering from alopecia attempt to improve their hair through extensive manipulation, which only increases problems. Frequent haircuts to minimize split ends, accompanied by gentle handling of the fragile fibers, is best. This chapter offers the dermatologist insight into hair care recommendations for the alopecia patient.

  18. 斑秃464例临床资料分析

    Institute of Scientific and Technical Information of China (English)

    王博; 杨淑霞

    2011-01-01

    @@ 斑秃(alopeciaareata,AA)是一种非瘢痕性、自身免疫性、炎症性毛发脱失性疾病.可分为单灶性、多片性、全秃(alopecia totalis,AT)、普秃(alopecia universalis,AU)、急性弥漫性斑秃(acute diffuse and total alopecia,ADTA)等多种类型,其中,ADTA是较晚提出的一种亚型.

  19. Discovery of 7-methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): a potent and selective transforming growth factor-β type I receptor inhibitor as a topical drug for alopecia.

    Science.gov (United States)

    Amada, Hideaki; Asanuma, Hajime; Koami, Takeshi; Okada, Atsushi; Endo, Mayumi; Ueda, Yasuji; Naruse, Takumi; Ikeda, Akiko

    2013-01-01

    7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole 11 (TASP0382088) was synthesized and evaluated as transforming growth factor-β (TGF-β) type I receptor (also known as activin receptor-like kinase 5 or ALK5) inhibitor. Compound 11, a potent and selective ALK5 inhibitor, exhibited good enzyme inhibitory activity (IC50=4.8 nM) as well as inhibitory activity against TGF-β-induced Smad2/3 phosphorylation at a cellular level (IC50=17 nM). The introduction of a methoxy group to the benzothiazole ring in 1 and the break up of the planarity between the imidazole ring and the thiazole ring improved the solubility in the lotion base of 11. Furthermore, the topical application of 3% 11 lotion significantly inhibited Smad2 phosphorylation in mouse skin at 8 h after application (71% inhibition, compared with vehicle-treated animals).

  20. Investigation and Analysis on Correlational Factors and Constitution of Traditional Chinese Medicine of Androgenetic Alopecia%雄性激素源性脱发发病相关因素及其与中医体质关系的调查分析

    Institute of Scientific and Technical Information of China (English)

    李婧; 朱其杰

    2012-01-01

    Objective: Through the investigation on general conditions and correlational factors, we analyse epidemiologica] characteristics, and explore its relationship with constitution of Traditional Chinese Medicine. Methods : 76 palients with AGA and 72 cases of control group were enrolled in this questionnaire, analyzing by SPSS 17.0. Results: The time of shampoo, consumption fat, life-work pressure, mental labor were risk factors, sleep time each day and satisfaction of life were protective factors. To analyse constitution of prevalence group and normal control group, it appeared that gentleness type occupied the most part , among which, 55.3% in prevalence group, 65.3% in normal control group, pathological type occupied 44.7% and 34.7%. To analyse correlational factors of gentleness type and pathological type in two groups by multivariate logistic regiession , it showed that male sex was associated with the incidence of AGA, the time of shampoo, consumption fat, life-work pressure and mental labor were risk factors of gentleness type, the time of shampoo and mental labor were risk factors of pathological type, and sleep time each day was protective factor of gentleness type and pathological type. Conclusion : Constitutional classification of two groups have no difference, and constitution of two groups haven't regularity.The time of shampoo, consumption fat, life-work of pressure, mental labor and so on are associated with the incidence of AGA.%目的:通过本病患者一般情况及发病相关因素的调查,分析本病的流行病学特征,并探讨其与中医体质的关联性.方法:对76例患者,及72例正常对照组进行问卷调查,结果采用SPSS17.0对数据进行分析.结果:洗头次数、食用肥肉、生活工作压力、脑力劳动是发病危险因素,每日睡眠时间、生活满意程度是保护因素.患病组及正常对照组体质调查以平和质为主,分别占55.3%、65.3%,偏颇质分别为44.7%、34.7%.偏颇质中以湿热质为主,占42.9%、13.9%.对两组平和质、偏颇质相关因素进行多因素logistic回归分析统计,发现平和质男性性别与发病有关,洗头次数、食用肥肉、生活工作压力、脑力劳动是平和质发病危险因素;洗头次数、脑力劳动是偏颇质发病危险因素,每日睡眠时间是平和质和偏颇质发病的保护因素.结论:患病组与正常对照组中医体质分布无差异,未发现中医体质的规律性.洗头次数、食用肥肉、生活工作压力、脑力劳动等与雄性激素发病有一定相关性.

  1. Mutations in ANTXR1 Cause GAPO Syndrome

    NARCIS (Netherlands)

    Stranecky, V.; Hoischen, A.; Hartmannova, H.; Zaki, M.S.; Chaudhary, A.; Zudaire, E.; Noskova, L.; Baresova, V.; Pristoupilova, A.; Hodanova, K.; Sovova, J.; Hulkova, H.; Piherova, L.; Hehir-Kwa, J.Y.; Silva, D. De; Senanayake, M.P.; Farrag, S.; Zeman, J.; Martasek, P.; Baxova, A.; Afifi, H.H.; Croix, B. St.; Brunner, H.G.; Temtamy, S.; Kmoch, S.

    2013-01-01

    The genetic cause of GAPO syndrome, a condition characterized by growth retardation, alopecia, pseudoanodontia, and progressive visual impairment, has not previously been identified. We studied four ethnically unrelated affected individuals and identified homozygous nonsense mutations (c.262C>T [

  2. Disease: H00670 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available unusually deformed hair shaft and alopecia. It has been named for the beaded appearance of affected hairs. M...H00670 Monilethrix Monilethrix is a disease of the hair cortex characterized by an

  3. Keratosis Follicularis Spinulosa Decalvans Is Caused by Mutations in MBTPS2

    NARCIS (Netherlands)

    Aten, Emmelien; Brasz, Lisa C.; Bornholdt, Dorothea; Hooijkaas, Ingeborg B.; Porteous, Mary E.; Sybert, Virginia P.; Vermeer, Maarten H.; Vossen, Rolf H. A. M.; van der Wielen, Michiel J. R.; Bakker, Egbert; Breuning, Martijn H.; Grzeschik, Karl-Heinz; Oosterwijk, Jan C.; den Dunnen, Johan T.

    2010-01-01

    Keratosis Follicularis Spinulosa Decalvans (KFSD) is a rare genetic disorder characterized by development of hyperkeratotic follicular papules on the scalp followed by progressive alopecia of the scalp, eyelashes, and eyebrows. Associated eye findings include photophobia in childhood and corneal dys

  4. Hair loss

    Science.gov (United States)

    ... SA, Stough DB, Rogers NE. Hair restoration. In: Bolognia JL, Jorizzo JL, Schaffer JV, eds. Dermatology . 3rd ... Sinclair RD, El Shabrawi-Caelen L. Alopecias. In: Bolognia JL, Jorizzo JL, Schaffer JV, eds. Dermatology . 3rd ...

  5. Disease: H01181 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ll immunodeficiency congenital alopecia and nail dystrophy (TIDAND) is a severe combined immunodeficiency (S...ata C Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency ass

  6. Vitiligo

    Science.gov (United States)

    ... you trust, whether that's a family member, friend, teacher, counselor, or support group. There are plenty of people who love you just the way you ... Hair, and Nails Body Image and Self-Esteem Skin Biopsy Alopecia: Kayla's Story ...

  7. Disease: H00601 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available osclerosis can cause the death at an average age of 13.5...p micrognathia, alopecia, prominent scalp vein, and wrinkled, aged-looking skin within the first year of life. Severe premature ather

  8. Progeria

    Directory of Open Access Journals (Sweden)

    Kaur Charandeep

    2000-01-01

    Full Text Available A case of progeria is being reported in a 7-year old boy. He had characteristic facies, short stature, alopecia, high pitched voice, coxa valga and sclerodermatous changes in skin.

  9. Autoimmune diseases associated with neurofibromatosis type 1.

    Science.gov (United States)

    Nanda, Arti

    2008-01-01

    Associations of autoimmune diseases with neurofibromatosis type 1 have been rarely described. In the present report, we describe two patients of neurofibromatosis type 1 having an association with vitiligo in one, and alopecia areata and autoimmune thyroiditis in another. The associations of neurofibromatosis type 1 with vitiligo, alopecia areata, and autoimmune thyroiditis have not been reported earlier. Whether these associations reflect a causal relationship with neurofibromatosis type 1 or are coincidental needs to be settled.

  10. IMPORTANCE OF THE TRICHOSCOPY IN SCALP DYSESTHESIA

    Directory of Open Access Journals (Sweden)

    Maria Bibiana Leroux

    2013-10-01

    Full Text Available The trichoscopy has been incorporated as a first hand method in patients consulting for scalp problems. Magnifying glass or digital microscope that permit the direct visualization of the hair shaft and the perifolicullar skin are utilized to diagnose cicatricial and non-cicatricial alopecia. A female patient with an alopecia plaque associated with a scalp dysesthesia in which trichoscopy was very useful in its diagnosis is presented.

  11. Dermatopathia pigmentosa reticularis: A rare reticulate pigmentary disorder

    Directory of Open Access Journals (Sweden)

    Vinay Shanker

    2013-01-01

    Full Text Available Dermatopathia pigmentosa reticularis is a rare ectodermal dysplasia with a triad of generalized reticulate hyperpigmentation, noncicatricial alopecia, and onychodystrophy. We report a case of a 21 year old woman who had generalized reticulate pigmentation, diffuse noncicatricial alopecia and onychodystrophy of finger and toe nails. Along with this triad she had palmoplantar keratoderma and poorly developed dermatoglyphics. There was no evidence of involvement of other ectodermally derived organ.

  12. Queratose folicular espinulosa decalvante: relato de caso Keratosis follicularis spinulosa decalvans: case report

    Directory of Open Access Journals (Sweden)

    Alceu L. C. V. Berbert

    2010-08-01

    Full Text Available A queratose folicular espinulosa decalvante é afecção rara, de transmissão genética ligada ao X ou esporádica, caracterizada por hiperqueratose folicular e alopecia cicatricial. Inicia-se, geralmente, na primeira infância, exacerbando-se na adolescência. As terapias são pouco efetivas, com tratamento frustrante, quando já há alterações predominantemente cicatriciais. Relata-se caso de criança com quadro de alopecia cicatricial intensa, com alterações precoces (já ao nascimento e rápida evolução para alopecia difusa cicatricial do couro cabeludo, o que tornou o tratamento limitado e desapontador.Keratosis follicularis spinulosa decalvans is a rare disease, with genetic transmission either X-linked or sporadic, characterized by follicular hyperkeratosis and cicatricial alopecia. The disease usually begins in early childhood exacerbating throughout adolescence. The therapies are somewhat effective, with frustrating treatment when there are changes which are predominantly cicatricial. It is reported a case of child with intense cicatricial alopecia, with precocious changes (already present at birth that rapidly evolved to diffuse cicatricial alopecia on the scalp, which has limited the treatment, with disappointing results.

  13. Thallium and arsenic poisoning in a small midwestern town.

    Science.gov (United States)

    Rusyniak, Daniel E; Furbee, R Brent; Kirk, Mark A

    2002-03-01

    Thallium and arsenic have been used as a means of criminal poisoning. Although both manifest characteristically with peripheral neuropathies, thallium is associated with alopecia and arsenic with gastrointestinal symptoms. We describe the symptoms, physical findings, diagnostic test results, and outcomes in a group of men poisoned with thallium and arsenic. Seven patients had evidence of elevated thallium levels, and 2 patients had elevated arsenic and thallium levels. The most commonly reported symptoms included myalgias, arthralgias, paresthesias, and dysesthesias. Five patients developed alopecia. All patients with symptoms and peripheral neuropathies had characteristic blackening of their hair roots. Initially treated with dimercaptosuccinic acid, patients were switched to multiple-dose activated charcoal after testing revealed thallium poisoning. By 6 months, all patients' symptoms and peripheral neuropathies improved, but 5 patients had ongoing psychiatric problems. Thallium remains a means of criminal poisoning and should be considered in any patient with a rapidly progressing peripheral neuropathy with or without alopecia.

  14. Graham-Little Piccardi Lassueur Syndrome: case report Síndrome de Graham-Little Piccardi Lassueur: relato de caso

    Directory of Open Access Journals (Sweden)

    Raquel Bissacotti Steglich

    2012-10-01

    Full Text Available A 33-year-old woman presented with a 3-year history of progressive alopecia of the scalp. Past treatment with hydroxicloroquine did not show improvement. Physical examination revealed multiple areas of alopecia with atrophic aspect of the scalp, and axillary and pubic hypotrichosis. Dermoscopy showed hyperkeratosis and accentuation of follicular ostia. Anatomopathological examination revealed decrease in the number of hair follicles, upper perifollicular infiltrate and areas with fibrosis. The Piccardi-Lassueur-Graham-Little syndrome is a rare disorder, characterized by the triad of multifocal scarring alopecia of the scalp, keratotic follicular eruption and hypotrichosis of axillary and pubic regions. Management is a challenge and many medications tried have controversial results. We report a case of this rare syndrome which improved with corticoids.Mulher, 33 anos, apresenta quadro de alopecia progressiva do couro cabeludo há 3 anos. Tratamento com hidroxicloroquina há 12 meses, sem apresentar melhora. Ao exame físico exibe múltiplas áreas de alopecia cicatricial no couro cabeludo, além de hipotricose axilar e pubiana. A dermatoscopia evidencia hipercetose folicular e acentuação dos óstios foliculares. O exame anatomopatológico revela diminuição do número de folículos pilosos, infiltrado perifolicular e fibrose. A síndrome de Graham-Little Piccardi Lassueur é uma dermatose rara, caracterizada pela tríade de alopecia cicatricial multifocal do couro cabeludo, ceratose folicular disseminada e hipotricose das regiões axilares e pubianas. A terapêutica desta dermatose é um desafio, muitas medicações relatadas tem resultados controversos. Relatamos o caso desta síndrome rara que apresentou melhora com corticoterapia.

  15. Dermoscopic findings in scalp psoriasis and seborrheic dermatitis; Two new signs; Signet ring vessel and hidden hair

    Directory of Open Access Journals (Sweden)

    Melike Kibar

    2015-01-01

    Full Text Available Background: Psoriasis and seborrheic dermatitis are both chronic erythemato-squamous dermatoses that can involve the scalp. It may be difficult to differentiate these two diseases when there is isolated scalp involvement. Recently, trichoscopy is commonly used to differentiate noncicatricial alopecias including psoriasis and seborrheic dermatitis that can lead to telogen effluvium (TE. Objectives: The objective of this study is to evaluate the trichoscopic figures that may help to differentiate scalp psoriasis and seborrheic dermatitis. Materials and Methods: Thirty one with scalp psoriasis and 112 patients with seborrheic dermatitis were enrolled. Trichoscopic examinations were performed using a videodermatoscope (MoleMax 3 ® . Trichoscopic findings of scalp psoriasis and seborrheic dermatitis were compared with each other, with 100 healthy individuals and with other noncicatricial alopecias including female androgenetic alopecia (FAGA (n: 138, male androgenetic alopecia (n: 63, FAGA of male pattern (FAGA.M (n: 5, alopecia areata (39, TE (n: 22 and trichotillomania (n: 4. Results: Atypical red vessels, red dots and globules (RDG, signet ring vessels (SRV, structureless red areas and hidden hairs (HH were statistically more common in psoriasis while twisted red loops and comma vessels (CV in seborrheic dermatitis. RDG were considered as the characteristic videodermatoscopic figure for psoriasis and arborizing red lines and CV for seborrheic dermatitis. In comparison with previous reports, our study yielded two new trichoscopic structures supporting the diagnosis of psoriasis; HH and SRV. Besides, according to our study, CV were described for the first time in seborrheic dermatitis and considered to be specific for seborrheic dermatitis. Conclusion: This study confirmed that trichoscopy might be useful in differentiating scalp psoriasis and seborrheic dermatitis from each other and from other noncicatricial alopecia with three trichoscopic

  16. Pityriasis amiantacea.

    Science.gov (United States)

    Moon, C M; Schissel, D J

    1999-03-01

    Pityriasis amiantacea is an easily recognizable cutaneous disease that is characterized by scaling of the scalp and temporary alopecia. The scaling, described as thick and asbestos-like, binds down tufts of hair. The alopecia may be temporary or scarring. Despite a well-established clinical description, no definitive etiology has been uncovered. This disease may represent seborrheic dermatitis, superficial fungal or pyogenic infections, lichen planus, or psoriasis. Histologically, the disease is characterized by eczematous features. We report a case of pityriasis amiantacea in an 11-year-old girl with simultaneous findings of psoriasis as well as review the literature on the etiology of this disease.

  17. Atrichia with Papular Lesions

    OpenAIRE

    Bansal, Manish; Manchanda, Kajal; Lamba, Sachin; Pandey, SS

    2011-01-01

    Atrichia with papular lesions (APL) is a rare autosomal recessive form of irreversible alopecia with onset at few months of age with papular keratin cysts over the body. It is associated with mutation in the Zinc finger domain of the human hairless gene on chromosome region 8p12. An eleven-year-old male presented with extensive alopecia starting at six months of age refractory to the treatment along with keratotic papules on the face and trunk. Biopsy from a papule showed mid-dermal keratin c...

  18. Trichotillomania

    Directory of Open Access Journals (Sweden)

    Siddappa K

    2003-03-01

    Full Text Available Trichotillomania is one of the types of traumatic alopecia and is defined as the irresistible urge to pull out the hair, accompanied by a sense of relief after the hair has been plucked. In trichotillomania alopecia results from deliberate efforts of the patients who is under tension or is psychologically disturbed. The condition maybe episodic and the chronic type is difficult to treat. The prevalence of the condition appears to be more common than previously believed. The purpose of this article is to discuss the various aspects of the condition including the available treatments.

  19. Hair biology and its comprehensive sequence in female pattern baldness: diagnosis and treatment modalities--Part I.

    Science.gov (United States)

    Sehgal, Virendra N; Srivastava, Govind; Aggarwal, Ashok K; Midha, Rashmi

    2013-01-01

    Hair may be a source of concern for patients when there is a change in its texture, amount, or thickness. It can present in women as androgenic alopecia also called female pattern baldness, and in men as adrogenic alopecia, also called male pattern baldness. Thinning/rarefaction affecting the vertex is a progressive condition, and hair loss in women has been interpreted and classified differently from that in men. The Ludwig classification for women's hair loss seems to be the most accepted assessment, which will be outlined in this review, along with the hair growth cycle that encompasses anagen, catagen, telogen, exogen, and kenogen.

  20. Queratose folicular espinulosa decalvante: relato de caso

    OpenAIRE

    2010-01-01

    A queratose folicular espinulosa decalvante é afecção rara, de transmissão genética ligada ao X ou esporádica, caracterizada por hiperqueratose folicular e alopecia cicatricial. Inicia-se, geralmente, na primeira infância, exacerbando-se na adolescência. As terapias são pouco efetivas, com tratamento frustrante, quando já há alterações predominantemente cicatriciais. Relata-se caso de criança com quadro de alopecia cicatricial intensa, com alterações precoces (já ao nascimento) e rápida evolu...

  1. Queratose folicular espinulosa decalvante: relato de caso Keratosis follicularis spinulosa decalvans: case report

    OpenAIRE

    2010-01-01

    A queratose folicular espinulosa decalvante é afecção rara, de transmissão genética ligada ao X ou esporádica, caracterizada por hiperqueratose folicular e alopecia cicatricial. Inicia-se, geralmente, na primeira infância, exacerbando-se na adolescência. As terapias são pouco efetivas, com tratamento frustrante, quando já há alterações predominantemente cicatriciais. Relata-se caso de criança com quadro de alopecia cicatricial intensa, com alterações precoces (já ao nascimento) e rápida evolu...

  2. Utilización de plasma rico en plaquetas en la profilaxisdel daño cutáneo inducido por radioterapia: modelo experimental

    Directory of Open Access Journals (Sweden)

    Lucía D'Oliveira-Pazos

    Full Text Available Introducción y Objetivos. La radioterapia conlleva la aparición de complicaciones cutáneas que afectan a la calidad de vida del paciente y en algunos casos condicionan la reconstrucción. El plasma rico en plaquetas (PRP es una terapia emergente; se trata de una sustancia autóloga, biocompatible, segura y económica. Está descrito su uso en disminución de la inflamación local, de los tiempos de curación de las heridas, en el tratamiento de lesiones por radioterapia y últimamente en el campo de la Medicina Estética mejorando la calidad de la piel. Nuestro estudio analiza el uso del PRP en la profilaxis de las lesiones cutáneas inducidas por radioterapia evaluando un modelo experimental. Material y Método. Realizamos un ensayo clínico controlado, doble ciego, en animales: 12 ratas Wistar, 2 para la obtención del PRP y 10 para el análisis clínico e histológico. Resultados. Del análisis clínico destacamos que de los sectores sin PRP previo a la radioterapia: 8 ratas presentaron alopecia y 7 hipopigmentación. La alopecia fue total en un 60%, parcial en 20% y un 20% no presentó alopecia. En los sectores con PRP: 4 presentaron alopecia y 3 hipopigmentación. La alopecia fue parcial en un 40%, un 60% no presentó alopecia y no hubo casos de alopecia total. Los resultados del análisis histológico demostraron un 100% de atrofia leve-moderada para los sectores con PRP. Por contrapartida, los sectores sin PRP presentaron 80% de atrofia moderada-severa y un 20% de atrofia leve-moderada. Conclusiones. Existe un beneficio en el uso del PRP como profilaxis de la alopecia (p < 0.05 e hipopigmentación (p < 0.1 inducido por radioterapia en un modelo experimental.

  3. Aprocta cylindrica (Nematoda) infection in a European Robin (Erithacus rubecula) in Britain.

    Science.gov (United States)

    Beckmann, Katie M; Harris, Eileen; Pocknell, Ann M; John, Shinto K; Macgregor, Shaheed K; Cunningham, Andrew A; Lawson, Becki

    2014-10-01

    A European Robin (Erithacus rubecula) found dead in England had marked blepharitis and periocular alopecia associated with Aprocta cylindrica (Nematoda: Aproctidae) and concurrent mixed fungal infections. Aprocta cylindrica should be considered a differential diagnosis in periocular abnormalities of robins and other insectivorous, migratory passerines in Western Europe.

  4. Coexistence of congenital giant melanocytic nevus of the scalp with cranial defect, poliosis, and hair loss.

    Science.gov (United States)

    Lee, Woo J; Lee, Sang M; Won, Chong H; Chang, Sung E; Lee, Mi W; Choi, Jee H; Moon, Kee C

    2013-01-01

    Congenital melanocytic nevi (CMN) are pigmented lesions presenting on the skin in approximately 1% of all newborns at or shortly after birth. CMN have been described as being associated with several anomalies, including cranial bone hypertrophy, scoliosis, and spina bifida. This is the first report to describe a giant congenital melanocytic nevus on the scalp associated with cranial involvement, poliosis, and alopecia.

  5. Peginterferon plus ribavirin versus interferon plus ribavirin for chronic hepatitis C

    DEFF Research Database (Denmark)

    Hauser, Goran; Awad, Tahany; Brok, Jesper

    2014-01-01

    .96 to 1.07; 12 trials). No significant differences were reported between the two treatment groups regarding anaemia, headache, rigours, myalgia, pyrexia, weight loss, asthenia, depression, insomnia, irritability, alopecia, pruritus, skin rash, thyroid malfunction, decreased appetite, or diarrhoea. We were...

  6. The Use of Megestrol Acetate in Some Feline Dermatological Problems

    OpenAIRE

    Gosselin, Y.; Chalifoux, A.; Papageorges, M.

    1981-01-01

    Twenty-one cats were treated with megestrol acetate because they were showing clinical signs associated with one of the following problems: eosinophilic ulcer, eosinophilic plaque, neurodermatitis, endocrine alopecia and miliary dermatitis. The dosage schedule was 5 mg orally per day per cat for seven days, then 5 mg every three days for 21 days.

  7. Genetic dissection of two Pakistani families with consanguineous localized autosomal recessive hypotrichosis (LAH

    Directory of Open Access Journals (Sweden)

    Seyyedha Abbas

    2014-07-01

    Conclusion:Both families were tested for linkage by genotyping polymorphic microsatellite markers linked to known alopecia loci. Family A excluded all known diseased regions that is suggestive of some novel chromosomal disorder. However, sequencing of P2RY5 gene in family B showed no pathogenic mutation.

  8. The acyl-CoA binding protein is required for normal epidermal barrier function in mice

    DEFF Research Database (Denmark)

    Bloksgaard, Maria; Bek, Signe; Marcher, Ann-Britt;

    2012-01-01

    The acyl-CoA binding protein (ACBP) is a 10 kDa intracellular protein expressed in all eukaryotic species. Mice with targeted disruption of Acbp (ACBP(-/-) mice) are viable and fertile but present a visible skin and fur phenotype characterized by greasy fur and development of alopecia and scaling...

  9. GAPO syndrome : a new case of this rare syndrome and a review of the relative importance of different phenotypic features in diagnosis

    NARCIS (Netherlands)

    Bacon, W; Hall, RK; Roset, JP; Boukari, A; Tenenbaum, H; Walter, B

    1999-01-01

    The case of GAPO syndrome reported here is the 24th recorded case, 23 cases having been published previously. The 29-year-old male under discussion presents all the typical features of the syndrome, having short stature, dysmorphic craniofacial features. total alopecia and pseudoanodontia. Orally, t

  10. Combined doxorubicin and paclitaxel in advanced breast cancer

    DEFF Research Database (Denmark)

    Gehl, J; Boesgaard, M; Paaske, T;

    1996-01-01

    -550). The main toxicities were neutropenia, parestesia, nausea/vomiting, alopecia, myalgia and cardiotoxicity. Fifteen patients (50%) had reductions of left ventricular ejection fraction of below normal levels and 6 of these patients (20%) developed congestive heart failure. CONCLUSION: The combination...

  11. Repeated monthly epicutaneous challenges with diphenylcyclopropenone result in a clinically reproducible level of contact allergy in de novo sensitized individuals

    DEFF Research Database (Denmark)

    Mose, K F; Andersen, F; Skov, L;

    2016-01-01

    Diphenylcyclopropenone (DPCP) has been used as an experimental contact allergen in humans and for topical immunotherapy of patients with alopecia areata. However, the efficacy is mostly based on case series. Randomized controlled clinical trials are lacking(1) , as is detailed descriptions of how...

  12. A new amyloidosis caused by fibrillar aggregates of mutated corneodesmosin

    DEFF Research Database (Denmark)

    Caubet, Cécile; Bousset, Luc; Clemmensen, Ole;

    2010-01-01

    Heterozygous nonsense mutations in the CDSN gene encoding corneodesmosin (CDSN), an adhesive protein expressed in cornified epithelia and hair follicles, cause hypotrichosis simplex of the scalp (HSS), a nonsyndromic form of alopecia. Truncated mutants of CDSN ((mut)CDSN), which bear the N...

  13. Granulomatous mycosis fungoides presenting as an acquired ichthyosis.

    Science.gov (United States)

    Eisman, S; O'Toole, E A; Jones, A; Whittaker, S J

    2003-03-01

    We report a case of a 69-year-old gentleman who presented with a 3-month history of unexplained fevers and malaise who developed generalized pruritus, alopecia and an ichthyosiform erythematous eruption on his forearms, legs, chest and back. Skin histology, immunophenotyping and molecular features were consistent with granulomatous mycosis fungoides. He has been successfully treated with twice weekly PUVA photochemotherapy.

  14. Three cases of immune-mediated adnexal skin disease treated with cyclosporin.

    Science.gov (United States)

    Noli, Chiara; Toma, Stefano

    2006-02-01

    Cyclosporin is currently considered a new and interesting drug in veterinary dermatology for the treatment of immune-mediated skin diseases, and a safe and effective alternative to immunosuppressive therapy with glucocorticoids. The authors report a case of granulomatous folliculitis and furunculosis and of sebaceous adenitis in two cats and a case of alopecia areata in a dog, successfully controlled with cyclosporin.

  15. Clomipramine-induced urinary retention in a cat.

    Science.gov (United States)

    Pfeiffer, E; Guy, N; Cribb, A

    1999-04-01

    A 10-year-old, female, spayed shorthair with presumed psychogenic alopecia was treated with clomipramine (1 mg/kg body weight/day). The cat developed urinary retention within 2 days. Clomipramine was discontinued. Clinical signs resolved over the next 7 days. The urinary retention was attributed to the anticholinergic effects of clomipramine.

  16. Mammary hypertrophy in an ovariohysterectomized cat.

    Science.gov (United States)

    Pukay, B P; Stevenson, D A

    1983-05-01

    A four year old ovariohysterectomized domestic short-haired cat under treatment for behavioral urine spraying and idiopathic alopecia developed mammary gland hypertrophy following treatment with megestrol acetate. Withdrawal of the progestin and treatment with androgen failed to cause regression of the hypertrophy. The affected mammary gland was surgically excised and recovery was uneventful.

  17. Cutaneous lymphoid hyperplasia mimicking cutaneous lymphoma in a hyperthyroid cat.

    Science.gov (United States)

    Snead, Elisabeth; Kerr, Moira; Macdonald, Valerie

    2013-10-01

    A 12-year-old neutered male domestic shorthair cat presented for chronic, localized, swelling and crusting of the left upper lip, weight loss, sporadic vomiting, and focal alopecia between the scapulae was diagnosed with hyperthyroidism and regional eosinophilic lymphadenitis. Treatment with methimazole exacerbated an underlying hypersensitivity disorder leading to marked generalized lymphadenopathy that histologically mimicked lymphoma.

  18. Changing trends in hair restoration surgery

    Directory of Open Access Journals (Sweden)

    Venkataram Mysore

    2006-01-01

    Full Text Available Androgenetic alopecia is an important and common cause for baldness. Despite recent advances, the drug therapy of this condition remains unsatisfactory. Surgical hair restoration is the only permanent method of treating this condition. Introduction of recent techniques such as follicular unit transplantation have improved the cosmetic results and patient satisfaction. This article discusses the latest trends in hair restoration surgery.

  19. POLYCYSTIC OVARIES WITH STROMAL HYPERTHECOSIS: A RARE PRESENTATION

    Directory of Open Access Journals (Sweden)

    Shaila

    2016-05-01

    Full Text Available Presenting a 47-year-old peri-menopausal lady with hypomenorrhoea, temporal baldness, alopecia, hirsutism. The histopathology was polycystic ovaries with stromal hyperthecosis. Hughesdon described hyperthecosis as a severe form of PCOS. Hyperthecosis is rare in young women, with clinical features similar to PCOS. However, these women are usually more virilised.

  20. Disease: H00740 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available enital ichthyosis follicularis and noncicatricial universal alopecia. Photophobia is also present in early childhood. Other features...P) syndrome: report of a new family with additional features and review. Am J Med Genet A 124A:323-7 (2004)

  1. Progeria (Hutchison-Gilford syndrome) in siblings: in an autosomal recessive pattern of inheritance.

    Science.gov (United States)

    Raghu, T Y; Venkatesulu, G A; Kantharaj, G R; Suresh, T; Veeresh, V; Hanumanthappa, Y

    2001-01-01

    Progeria is an autosomal dominant, premature aging syndrome. Six and three year old female siblings had sclerodermatous changes over the extremities, alopecia, beaked nose, prominent veins and bird-like facies. Radiological features were consistent with features of progeria. The present case highlights rarity of progeria in siblings with a possible autosomal recessive pattern.

  2. Minoxidil induced hypertrichosis in a 2 year-old child [v1; ref status: indexed, http://f1000r.es/1vw

    Directory of Open Access Journals (Sweden)

    Ingrid Herskovitz

    2013-10-01

    Full Text Available We report a case of a 2 year-old male patient who developed generalized hypertrichosis after 2 months of treatment with 5% minoxidil foam for alopecia areata. This report highlights the danger of prescribing  topical minoxidil to young children and the need to correctly instruct caretakers about its administration.

  3. Disease: H00742 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00742 Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leu...kocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC) Neonatal ichthyosis-sclerosing cholangitis (N...henne X, Gilis A, Jacquemin E, Henrion Caude A, Girard M, Gonzales E, Revencu N, Reding R, Wanty C, Smets F, Sokal EM Neonatal

  4. Linear Lichen Planopilaris of the Face: Case Report and Review.

    Science.gov (United States)

    Asz-Sigall, Daniel; González-de-Cossio-Hernández, Ana Cecilia; Rodríguez-Lobato, Erika; Ortega-Springall, María Fernanda; Vega-Memije, María Elisa; Arenas Guzmán, Roberto

    2016-09-01

    We describe the case of a 45-year-old man who presented with a 5-month history of unilateral pruritic linear erythematous papules and atrophy on the chin and mandibular area. Dermoscopy showed areas of cicatricial alopecia with absence of follicular openings, perifollicular erythema and pigment. Lichen planopilaris of the face is a rare variant with only 13 cases reported in the literature.

  5. A role for b-cell-depleting agents in treating psoriatic skin lesions induced by tumor necrosis factor-alpha antagonists: A case report and literature review

    Directory of Open Access Journals (Sweden)

    Ancuta Codrina Mihaela

    2014-01-01

    Full Text Available Despite recent advances in understanding the pathological pathways, clinical pattern and management opportunities for new-onset psoriasis as a paradoxical adverse event in patients receiving TNF inhibitors for their immune-mediated disorder, there is a subset of patients who are either partial responders or non-responders, whatever the therapeutic scenario. We present the case of new-onset psoriasis and severe alopecia development in a case study of long-standing rheumatoid arthritis (RA treated with adalimumab (ADA and leflunomide. Since skin lesions and alopecia are resistant to the classic protocol (topical treatment, ADA discontinuation and RA becomes highly active, rituximab (RTX was started. Dramatic improvement in joint disease, total remission of alopecia and partial remission of pustular psoriasis were described after the first RTX cycle. Although B-cell-depleting agents result in controversial effects on psoriatic skin lesions, this is the first case of ADA-induced psoriasis and alopecia that improved under RTX, suggesting a possible role in treating such a patient population.

  6. Bad Hair Day: Testosterone and Wnts.

    Science.gov (United States)

    Nelson, Amanda M; Garza, Luis A

    2015-11-01

    Androgens have an important role in normal skin physiology, as well as in the pathogenesis of many skin conditions, such as acne vulgaris, hirsutism, and androgenic alopecia. Kretzchumar et al. (2015) investigate the relationship between androgen receptor (AR) signaling and β-catenin/Wnt signaling pathways in murine hair follicles.

  7. Bad Hair Day: Testosterone and Wnts

    OpenAIRE

    Nelson, Amanda M.; Garza, Luis A.

    2015-01-01

    Androgens have an important role in normal skin physiology, as well as in the pathogenesis of many skin conditions, such as acne vulgaris, hirsutism, and androgenic alopecia. Kretzchumar et al. (2015) investigate the relationship between androgen receptor (AR) signaling and β-catenin/Wnt signaling pathways in murine hair follicles.

  8. Clinical phenotype associations with various types of anti-dsDNA antibodies in patients with recent onset of rheumatic symptoms. Results from a multicentre observational study

    DEFF Research Database (Denmark)

    Compagno, Michele; Rekvig, Ole P; Bengtsson, Anders A

    2014-01-01

    showed that combined positivity of CLIFT and ELISA was also associated with lymphopenia. CONCLUSIONS: Our results show that different anti-dsDNA antibody specificities are associated with nephropathy, pleuritis, alopecia and lymphopenia, regardless of the diagnosis. It may challenge the importance...

  9. Steroid responsive mononeuritis multiplex in the Cronkhite-Canada syndrome

    Directory of Open Access Journals (Sweden)

    YL Lo

    2016-11-01

    Full Text Available The Cronkhite-Canada syndrome (CCS is a rare disorder of unknown origin characterized by generalized gastrointestinal polyposis, alopecia, hyperpigmentation and onychodystrophy. We report a case of CCS with concomitant presentation of mononeuritis multiplex. The electrophysiological findings and steroid responsiveness suggests presence of an autoimmune mechanism.

  10. The Use of High-Density SNP Array to Map Homozygosity in Consanguineous Families to Efficiently Identify Candidate Genes: Application to Woodhouse-Sakati Syndrome

    Directory of Open Access Journals (Sweden)

    Molly B. Sheridan

    2015-01-01

    Full Text Available Two consanguineous Qatari siblings presented for evaluation: a 17-4/12-year-old male with hypogonadotropic hypogonadism, alopecia, intellectual disability, and microcephaly and his 19-year-old sister with primary amenorrhea, alopecia, and normal cognition. Both required hormone treatment to produce secondary sex characteristics and pubertal development beyond Tanner 1. SNP array analysis of both probands was performed to detect shared regions of homozygosity which may harbor homozygous mutations in a gene causing their common features of abnormal pubertal development, alopecia, and variable cognitive delay. Our patients shared multiple homozygous genomic regions; ten shared regions were >1 Mb in length and constituted 0.99% of the genome. DCAF17, encoding a transmembrane nuclear protein of uncertain function, was the only gene identified in a homozygous region known to cause hypogonadotropic hypogonadism. DCAF17 mutations are associated with Woodhouse-Sakati syndrome, a rare disorder characterized by alopecia, hypogonadotropic hypogonadism, sensorineural hearing loss, diabetes mellitus, and extrapyramidal movements. Sequencing of the coding exons and flanking intronic regions of DCAF17 in the proband revealed homozygosity for a previously described founder mutation (c.436delC. Targeted DCAF17 sequencing of his affected sibling revealed the same homozygous mutation. This family illustrates the utility of SNP array testing in consanguineous families to efficiently and inexpensively identify regions of genomic homozygosity in which genetic candidates for recessive conditions can be identified.

  11. Systemic sarcoidosis with necrobiosis lipoidica-like scalp lesions

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner

    1977-01-01

    A 78-year-old woman is described, having systemic sarcoidosis for 15 years, involving the lungs, lymph nodes and the skin. Over the last 6 years she developed a progressive cicatricial alopecia with histologic changes of the granulomatous type of necrobiosis lipoidica surrounded by sarcoid...

  12. Goya and tinea favosa*

    Science.gov (United States)

    Vallarelli, Andrelou Fralete Ayres

    2014-01-01

    A case of a tinea favosa involving the scalp of a child represented in the painting "Boys climbing a tree" (Muchachos trepando a un árbol), by Francisco Goya y Lucientes, with pictorial representation of favic scutula and consequent alopecia. PMID:25387510

  13. Goya and tinea favosa.

    Science.gov (United States)

    Vallarelli, Andrelou Fralete Ayres

    2014-01-01

    A case of a tinea favosa involving the scalp of a child represented in the painting "Boys climbing a tree" (Muchachos trepando a un árbol), by Francisco Goya y Lucientes, with pictorial representation of favic scutula and consequent alopecia.

  14. Progeria (Hutchison - Gilford syndrome in siblings: In an autosomal recessive pattern of inheritance

    Directory of Open Access Journals (Sweden)

    Raghu Tanjore

    2001-09-01

    Full Text Available Progeria is an autosomal dominant, premature aging syndrome. Six and three year old female siblings had sclcrodermatous changes over the extremities, alopecia, beaked nose, prominent veins and bird-like facies. Radiological features were consistent with features of progeria. The present case highlights rarity of progeria in siblings with a possible autosomal recessive pattern.

  15. Safety and effectiveness of scalp cooling in cancer patients undergoing cytotoxic treatment

    NARCIS (Netherlands)

    Hurk, Corina Johanna Geertruida van den

    2013-01-01

    Various cytotoxics cause severe alopecia, it is estimated to affect more than 15.000 Dutch cancer patients per year. Hair loss has high impact on the majority of these patients, they describe it as stigmatizing and a constant reminder of cancer disease. Scalp cooling decreases hair loss and is well

  16. Phase II activity of belinostat (PXD-101), carboplatin, and paclitaxel in women with previously treated ovarian cancer

    DEFF Research Database (Denmark)

    Dizon, Don S; Damstrup, Lars; Finkler, Neil J;

    2012-01-01

    % confidence interval, 26%-61%). When stratified by primary platinum status, the ORR was 44% among resistant patients and 63% among sensitive patients. The most common drug-related adverse events related to BelCaP were nausea (83%), fatigue (74%), vomiting (63%), alopecia (57%), and diarrhea (37...

  17. Hair loss in hospital medicine: a practical guide.

    Science.gov (United States)

    Macbeth, Abby; Harries, Matthew

    2012-07-01

    Alopecia may indicate underlying systemic disease and is associated with significant impairment of quality of life. A thorough history and examination, including specialist techniques, can give vital clues to the aetiology. This article provides an overview of the common and important hair loss disorders for the busy clinician.

  18. Tryptophan-induced eosinophilia-myalgia syndrome.

    OpenAIRE

    Criswell, L A; Sack, K. E.

    1990-01-01

    Eight patients who became ill while taking tryptophan had myalgia, fatigue, rash, fever, edema, alopecia, arthralgias, diminished joint motion, skin tightening, muscle cramping, and distal paresthesias. Three had shortness of breath, and one had pulmonary hypertension. Laboratory abnormalities included peripheral eosinophilia, leukocytosis, thrombocytosis, raised erythrocyte sedimentation rate, and elevated serum levels of aldolase, lactate dehydrogenase, and liver enzymes. Of 4 chest radiogr...

  19. Polycystic ovary syndrome and acne.

    Science.gov (United States)

    Chuan, Sandy S; Chang, R Jeffrey

    2010-01-01

    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women. It is typically characterized by hyperandrogenism, chronic anovulation, and polycystic ovaries. Women with PCOS often experience dermatologic manifestations of hyperandrogenism, including hirsutism, acne vulgaris, and androgenic alopecia. This article will review the treatments for acne due to androgen excess in PCOS women.

  20. Correlation between the three kinds of common hair loss diseases, sleep quality and emotional factors%三种常见脱发性疾病与睡眠质量和情绪因素的相关性调查

    Institute of Scientific and Technical Information of China (English)

    王端; 徐巧瑜; 雷霞; 吴先林; 伍津津

    2013-01-01

    Objective To investigate the correlation between physiological alopecia, androgenetic alopecia, alopecia areata and sleep quality and emotional factors. Methods Patients from the outpatient dermatology of Daping Hospital from August 2011 to August 2012 diagnosed as physiological alopecia, androgenetic alopecia, alopecia areata and healthy collators were assessed by the pittsburgh sleep quality index (PSQI) and self rating anxiety scale (SAS). Results The total score of PSQI and SAS gradually increased with age in all the three kinds of hair loss and the normal control, which showed a statistically signiifcant difference between the different age groups (P45 years old) had differences (P<0.05). SAS score of alopecia areata and androgenetic alopecia in the youth group were higher than the national norm of China. Female patients had a greater inlfuence than male in PSQI and SAS. The pearson product moment related analysis (r=0.487, P=0.000) indicated that sleep quality and anxiety situation positively related. Conclusion Hair loss diseases, especially alopecia areata was affected by sleep quality and mental factors, so it is important to restore the good life habit and adjust emotion to prevent the onset of alopecia areata.%目的:调查和探讨生理性脱发、雄激素性脱发、斑秃与睡眠质量和情绪因素的相关性。方法采用匹兹堡睡眠质量指数(PSQI)及焦虑自评表(SAS),对我院皮肤科确诊为生理性脱发、雄激素性脱发、斑秃的患者及健康对照者进行调查和分析。结果3种脱发患者与健康对照者在青年组(15~29岁)、壮年组(30~44岁)、中老年组(>45岁)的PSQI及SAS得分逐渐增加,组间比较差异具有统计学意义(P<0.01)。斑秃患者PSQI总分>7分,有睡眠问题;在PSQI的7个指标中,青年组主要在睡眠质量、入睡时间、睡眠效率、睡眠障碍有差异(P<0.01);壮年组在睡眠质

  1. Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

    Directory of Open Access Journals (Sweden)

    Deren Özcan

    2015-12-01

    Full Text Available Background and Design: Lichen planopilaris (LPP is a type of cicatricial alopecia characterized by autoreactive lymphocytic destruction of the hair follicle. We aimed to evaluate the demographic, clinical and histopathological features, and treatment outcomes of patients with LPP. Materials and Methods: Medical reports of 25 patients, who have been diagnosed with LPP according to the clinical and histopathological findings between January 2006 and June 2012, were retrospectively reviewed. The transverse and vertical sections of scalp biopsy specimens were re-evaluated by a pathologist, and the findings were noted. Results: Of the 25 patients, 18 were female and 7 were male, the mean age was 49.8±12.4 years. Eighteen patients had been diagnosed with classic LPP and 7 patients with frontal fibrosing alopecia (FFA. The alopecia has begun in postmenopausal period in 5 patients with FFA. Alopecia was associated with pruritus, pain and/or burning in 19 patients. Extra-scalp involvement was observed in 11 patients. The most common clinical findings were follicular hyperkeratosis (92%, perifollicular erythema (48%, perifollicular lichenoid papules, and positive hair-pull test (44%. Dermatoscopic examination was performed in 14 patients, and most commonly, absence of follicular openings (100%, perifollicular scales (92.9% and perifollicular erythema (50% were noted. The most common diagnostic histopathological findingsmwere follicular vacuolar and lichenoid degeneration (88% and vacuolar and lichenoid interface changes (56%. Twenty-three patients who were started on treatment received topical, intramuscular and intralesional corticosteroids, topical minoxidil, oral tetracycline, cyclosporine A, and hydroxychloroquine either alone or in combination. Progression of alopecia was prevented and the symptoms and/or signs were reduced in 12 (75% of 16 patients whose follow-up data were available. Conclusion: LPP can be diagnosed accurately through a detailed

  2. Lymphocytic mural folliculitis and pancreatic carcinoma in a cat.

    Science.gov (United States)

    Lobetti, Remo

    2015-06-01

    A 9-year-old castrated domestic shorthair cat was presented with a 6 week history of progressive non-pruritic alopecia, polyphagia and weight loss. A diagnosis of lymphocytic mural folliculitis was made and the cat was treated with a combination of prednisolone and ciclosporin; this produced an improvement in the alopecia but no resolution. Sixteen months after the initial assessment and diagnosis, the cat was re-evaluated for intermittent vomiting and weight loss with normal appetite. On examination the dermatopathy was still evident and a mass involving the duodenum and pancreas was present, which was diagnosed as a pancreatic carcinoma. From this case it would appear that lymphocytic mural folliculitis might be an early dermatological manifestation of pancreatic neoplasia.

  3. Diffuse Hair Loss Induced by Sertraline Use

    Directory of Open Access Journals (Sweden)

    Yüksel Kıvrak

    2015-01-01

    Full Text Available Hair loss is a rare side effect of psychotropic drugs. The most related drug class with this side effect is the mood stabilizers. Studies reporting the sertraline-induced alopecia are limited in number. Sertraline is a potent antidepressant which inhibits the serotonin reuptake from the presynaptic terminals selectively. The reason for hair loss could not be elucidated completely. Psychotropic drugs are usually considered to lead to hair loss through influencing the telogen phase of hair follicle. This paper reports a 21-year-old male with diffuse hair loss induced by sertraline use and improved by quitting the drug. To the best of our knowledge, there are no other case reports on sertraline-induced alopecia within 2 weeks.

  4. 生发饮联合生发灵酊治疗雄激素源性脱发52例疗效观察

    Institute of Scientific and Technical Information of China (English)

    郑永平; 陈高飞; 王海棠

    2010-01-01

    @@ 雄激素源性脱发(premature alopecia,AGA),又名男性型秃发(male patterm alopecia, MP)A),属于中医"蛀发癣"范畴,严重影响了患者的容貌,给患者的社交及婚姻带来负性的影响.2006年1月~2009年5月,我们采用生发饮联合生发灵酊外涂局部皮损治疗雄激素源性脱发52例,取得了较好的疗效,并与50例外用5%米诺地尔(商品名:蔓迪,浙江万马制药)治疗比较,现将结果报道如下.

  5. Síndrome de Werner: Dos nuevos casos Werner´S Syndrome: Two New Cases

    Directory of Open Access Journals (Sweden)

    M Palombo

    2010-03-01

    Full Text Available Se comunican dos casos del síndrome de Werner, el primero es un hombre con canicie desde la tercera década de la vida y diabetes mellitus diagnosticada el año pasado. El segundo caso es un hombre con alopecia masculina desde los 30 años y cataratas. Ambos nos consultaron por úlceras muy dolorosas en piernas y tobillos. Se efectúa una revisión del síndrome de Werner.Two cases of Werner´s syndrome are reported. The first case is a man with grey hair since his 30s and diabetes mellitus diagnosed last year. The second case is a man with male alopecia since his 30s and cataracts, both consulted us for extremely painful ulcers in their legs and ankles. A review of the Werner´s syndrome is made.

  6. Science.gov (United States)

    De Quintana Sancho, A; Piris García, X; Valle García, J N; Hierro Cámara, M

    2016-12-30

    La alopecia frontal fibrosante (AFF) es un tipo de alopecia cicatricial cuya incidencia está aumentando de forma significativa en nuestro país. Se caracteriza por un retroceso en la línea de implantación del pelo a nivel frontotemporal que afecta mayoritariamente a mujeres postmenopaúsicas, con un impacto negativo en su calidad de vida. Se asocia a menopausia precoz en un 14% de los casos y a hipotiroidismo en un 15%. Con respecto al tratamiento, son los inhibidores de la 5α-reductasa, los fármacos que han demostrado mejoría de la enfermedad en un mayor número de casos. Presentamos un caso de AFF en una mujer de 77 años tratada con éxito con finasteride a dosis de 2,5mg/día.

  7. Chewing lice Trichodectes pinguis pinguis in Scandinavian brown bears (Ursus arctos

    Directory of Open Access Journals (Sweden)

    Núria Fandos Esteruelas

    2016-08-01

    Full Text Available In April 2014 and 2015, we noted localized alopecia (neck, forelimbs, and chest and hyperpigmentation on two adult brown bears (Ursus arctos captured in central-south Sweden for ecological studies under the Scandinavian Brown Bear Research Project. In spring 2015, a brown bear was shot because of human-wildlife conflict in the same region. This bear also had extensive alopecia and hyperpigmentation. Ectoparasites were collected from the affected skin areas in all three individuals and preserved in ethanol for identification. Based on morphological characteristics, the lice were identified as Trichodectes spp. and Trichodectes pinguis pinguis. To our knowledge, these are the first reported cases of chewing lice in free-ranging brown bears in Scandinavia.

  8. Dermal Titanium Dioxide Deposition Associated With Intralesional Triamcinolone Injection.

    Science.gov (United States)

    Cohen, Brandon E; Bashey, Sameer; Cole, Christine; Abraham, Jerrold L; Ragsdale, Bruce; Ngo, Binh

    2016-12-01

    Cutaneous discoloration secondary to dermal deposition of titanium dioxide (TiO2) particles is recognized but seldom reported in the literature. In this report, the authors describe the case of a 61-year-old gentleman, with a long history of alopecia areata, who presented with numerous, discrete dark blue macules on the scalp. Scanning electron microscopy with energy dispersive x-ray spectroscopy analysis ultimately identified the macules as deposits of TiO2. The patient had a history of intralesional triamcinolone injections for management of alopecia areata. A sample of generic 0.1% triamcinolone acetonide paste was analyzed and found to contain many TiO2 particles analogous to those seen in the patient's biopsy sample. To the authors' knowledge, this is the first reported case of TiO2 deposition in the dermis likely resulting from topical combined with intralesional triamcinolone injection.

  9. Vitamin D Dependent Rickets Type II: Late Onset of Disease and Response to High Doses of Vitamin D

    Directory of Open Access Journals (Sweden)

    Soni Sachin

    2008-01-01

    Full Text Available Vitamin D dependent rickets Type II is a rare autosomal recessive disorder. The disorder is characterized by end organ hyporesponsiveness to vitamin D. Common presentation of the disorder is total body alopecia and onset of rickets during the second half of the first year of life. Patients may display progressive rachitic bone changes, hypocalcemia and secondary hyper-parathyroidism. It is differentiated from vitamin D dependent rickets type I by virtue of response to physiological doses of exogenous vitamin D in the later. Target organ hyporesponsiveness can be overcome by higher doses of vitamin D or its analogues. We report a case of vitamin D dependent rickets type II with onset of rickets at the age of thirteen years without alopecia progressing to marked disability by twenty three years of age. She responded to massive doses of vitamin D with significant clinical improvement after six months of therapy.

  10. Dermatologic manifestation of hyperandrogenism: a retrospective chart review.

    Science.gov (United States)

    Clark, Charlotte M; Rudolph, Jennifer; Gerber, Donald A; Glick, Sharon; Shalita, Alan R; Lowenstein, Eve J

    2014-01-01

    Several studies have described a wide spectrum of hyperandrogenism diseases, many of which are difficult to distinguish from each other. In order to better understand diseases of hyperandrogenism, the authors performed a retrospective study of the cutaneous features and metabolic findings in women with hyperandrogenism. A retrospective chart analysis compiled by three dermatologists in both academic and private settings was performed, including patients presenting with > or = 2 manifestations of hyperandrogenism. Relevant dermatologic and associated manifestations and laboratory and imaging study findings were reviewed. Moderate to severe acne was the most common manifestation. Other common manifestations that patients first presented with include hirsutism, acanthosis nigricans, androgenic alopecia, and skin tags. Oligomenorrhea was the most common systemic presenting sign. Statistical analysis of various clinical markers revealed correlations with hyperandrogenemia. Acanthosis nigricans and hirsutism were found to be useful clinical markers for hyperandrogenism, whereas androgenic alopecia was not. This study provides some insights into the presentation and diverse manifestations seen in hyperandrogenism.

  11. Role of 5α-reductase inhibitors in androgen-stimulated skin disorders.

    Science.gov (United States)

    Azzouni, Faris; Zeitouni, Nathalie; Mohler, James

    2013-02-01

    5α-reductase (5α-R) isozymes are ubiquitously expressed in human tissues. This enzyme family is composed of 3 members that perform several important biologic functions. 5α-R isozymes play an important role in benign prostate hyperplasia, prostate cancer, and androgen-stimulated skin disorders, which include androgenic alopecia, acne, and hirsutism. Discovery of 5α-R type 2 deficiency in 1974 sparked interest in development of pharmaceutical agents to inhibit 5α-R isozymes, and 2 such inhibitors are currently available for clinical use: finasteride and dutasteride. 5α-R inhibitors are US Food and Drug Administration (FDA)-approved for the treatment of benign prostate hyperplasia. Only finasteride is FDA-approved for treatment of male androgenic alopecia. This article reviews the pathophysiology of androgen-stimulated skin disorders and the key clinical trials using 5α-R inhibitors in the treatment of androgen-stimulated skin disorders.

  12. Molecular genetic basis for the rhino mouse from Chinese KM subcolony

    Institute of Scientific and Technical Information of China (English)

    TIAN Ming; XIONG Yuliang; WANG Wanyu; ZHANG Yaping

    2004-01-01

    Both the rhino mouse and hairless mouse resulted from hairless gene mutation, but they show different phenotypes of skin physiology. The rhino mouse has more similar histological characters to human papular alopecia. Therefore rhino mouse is a good experimental animal model for human papular alopecia. This study reports a hairless mouse named rhino KIZ, arose from KM colony in Kunming Institue of Zoology, by systematic studies on morphology, skin histopathology, gene sequence, pedigree and protein domain analysis. The results demonstrate that a C-to-T transition in exon 11 of hr gene (The mutant gene has been applied for a Chinese patent (patent No. 03135280)) results in the rhino KIZ. The rhino KIZ with clear genetic mechanism will be a useful animal model.

  13. Graham Little-Lassueur Syndrome with Hypertrophic Lichen Planus in a Patient with Chronic Hepatitis C

    Directory of Open Access Journals (Sweden)

    Badea Mihail Alexandru

    2016-03-01

    Full Text Available Graham Little-Lassueur Syndrome (GLLS is considered a form of lichen planopilaris which associates follicular lichen planus, cicatricial alopecia of the scalp and noncicatricial alopecia of the axillary and/or pubic regions. We present the case of a 47 years old female patient, known for 5 years with chronic hepatitis C and a poor therapeutic control of the disease due to Interferon intolerance. She presented to our clinic for the occurrence on the shins of some well-defined, intensely pruritic erythematous plaques, covered with thick scales, with a verrucous appearance, accompanied by excoriations. The skin biopsy reveal hypertrophic lichen planus on the shins and lichen planopilaris on the scalp. The patient was treated with systemic antihystamines, topical corticosteroids and salicylic acid under occlusion, emollients, phototherapy UVB narrow band 4 sessions/week for 3 weeks, cryotherapy. From our knowledge this is the first case of GLLS associated with chronic viral hepatis C.

  14. Lysocellin, a metabolite of the novel drug 'alopestatin', induces G1 arrest and prevents cytotoxicity induced by etoposide.

    Science.gov (United States)

    Takahara, Yoshinori; Yogosawa, Shingo; Maruyama, Sakiko; Watanabe, Noriko; Yokoyama, Hirofumi; Fukasawa, Kazuteru; Sukenaga, Yoshikazu; Kamiyama, Jun; Izumi, Moriatsu; Wakada, Miki; Zhang, Helin; Yoshizawa, Kaname; Kawa, Shigeyuki; Nikaido, Toshio; Sakai, Toshiyuki

    2006-04-01

    We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21WAF1/Cip1 and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down-regulated by the proteasome-dependent signal pathway in MG63 cells. In drug combination studies, we found that lysocellin treatment weakened the cytotoxic activity of etoposide in MG63 cells using a colony-formation assay. To study the in vivo efficacy of lysocellin, we isolated a novel compound related to lysocellin from the same streptomycete, and found that the novel drug is converted to lysocellin in vivo and decreases etoposide-induced alopecia in a neonatal rat model. We raise the possibility that this novel drug, named 'alopestatin', may be a promising agent against alopecia.

  15. Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders

    Directory of Open Access Journals (Sweden)

    Yu Ri Woo

    2017-02-01

    Full Text Available Erythroid differentiation regulator 1 (Erdr1 is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss disorders and five control subjects were retrieved, in order to assess their expression levels of Erdr1. Results revealed that expression of Erdr1 was significantly downregulated in the epidermis and hair follicles of patients with hair loss disorders, when compared to that in the control group. In particular, the expression of Erdr1 was significantly decreased in patients with alopecia areata. We propose that Erdr1 downregulation might be involved in the pathogenesis of hair loss, and could be considered as a novel biomarker for hair loss disorders.

  16. Hormonal therapy for acne: why not as first line therapy? facts and controversies.

    Science.gov (United States)

    Katsambas, Andreas D; Dessinioti, Clio

    2010-01-01

    Standard systemic therapeutic agents used in acne include oral antimicrobials, isotretinoin, and hormonal agents. Appropriate patient selection is the key to decide when to use hormonal agents as first-line therapy as well as to achieve optimal results. Indications of hormonal therapy in acne in girls and women include proven ovarian or adrenal hyperandrogenism, recalcitrant acne, acne not responding to repeated courses of oral isotretinoin, acne tarda, polycystic ovary syndrome, or the presence of clinical signs of hyperandrogenism such as androgenic alopecia or the presence of the seborrhea, acne, hirsutism, alopecia syndrome. We describe the hormonal agents currently available for acne treatment, discuss their indications and contraindications, and address the question of whether they may be used as a first-line therapy in acne.

  17. Zinc-deficiency acrodermatitis in a patient with chronic alcoholism and gastric bypass: a case report

    Directory of Open Access Journals (Sweden)

    Dariush Shahsavari

    2014-07-01

    Full Text Available Acquired adult-onset zinc deficiency is occasionally reported in patients with malnutrition states, such as alcoholism, or malabsorptive states, such as post-bariatric surgery. The defining symptoms of hypozincemia include a classic triad of necrolytic dermatitis, diffuse alopecia, and diarrhea. We report a case of zinc deficiency in a 39-year-old man with history of gastric bypass surgery and alcoholism. For this patient, severe hypozincemia confirmed acrodermatitis, and zinc supplementation was met with gradual improvement.

  18. Persistent docetaxel-induced supravenous erythematous eruption*

    OpenAIRE

    Fernandes, Karina de Almeida Pinto; Felix, Paulo Antônio Oldani

    2015-01-01

    Taxanes are drugs used to treat many types of cancer, including breast and lung cancer. The most common side effects of these drugs are neutropenia and mucositis. Signs of skin toxicity are observed in about 65% of cases and include alopecia, hypersensitivity reactions, persistent supravenous erythematous eruption, nail changes, scleroderma reactions and others. We report two cases of skin reaction to docetaxel and warn that it is not necessary to interrupt the treatment in these cases.

  19. Dissecting cellulitis (Perifolliculitis Capitis Abscedens et Suffodiens): a comprehensive review focusing on new treatments and findings of the last decade with commentary comparing the therapies and causes of dissecting cellulitis to hidradenitis suppura

    OpenAIRE

    Scheinfeld, Noah

    2014-01-01

    Dissecting cellulitis (DC) also referred to as to as perifolliculitis capitis abscedens et suffodiens (Hoffman) manifests with perifollicular pustules, nodules, abscesses and sinuses that evolve into scarring alopecia. In the U.S., it predominantly occurs in African American men between 20-40 years of age.  DC also occurs in other races and women more rarely.  DC has been reported worldwide.  Older therapies reported effective include: low dose oral zinc, isotretinoin, minocycline, sulfa drug...

  20. Folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: Systemic antibiosis (Metronidazole Plus Clindamycin), dermatosurgical approach, and high-dose isotretinoin

    OpenAIRE

    Georgi Tchernev

    2011-01-01

    Folliculitis et perifolliculitis capitis abscedens et suffodiens is a rare disease of unknown etiology. It is a suppurative process that involves the scalp, eventually resulting in extensive scarring and irreversible alopecia. The condition is also known as ‘acne necrotica miliaris’ or ‘Proprionibacterium’ folliculitis. Most often the disease affects men of African-American or African-Caribbean descent between 20 and 40 years of age. The clinical picture is determined by fluctuating painful f...

  1. Pattern of skin diseases in paediatric age group and adolescents

    Directory of Open Access Journals (Sweden)

    Sayal S

    1998-01-01

    Full Text Available A total of 300 patients from first day of life to 17 years of age were analysed for pattern of skin disorders. School going children formed majority (41.3% of cases followed by preschool children (32%. Infections formed the commonest disorder (31 % followed by eczemas (24%, papulosquamous disorders (12%, infestation (8.6% and urticaria (5.3% while vitiligo, acne vulgaris, alopecia areata and genodermatoses were seen in 2.7% cases each.

  2. Detoxification of Abrus precatorius L. seeds by Ayurvedic Shodhana process and anti-inflammatory potential of the detoxified extract

    OpenAIRE

    Dhoble, Sagar B.; Majumdar, Anuradha S.

    2014-01-01

    Background: Abrus precatorius seeds traditionally used for the treatment of sciatica and alopecia contains the toxic protein, abrin, a Type II Ribosome Inactivating Protein. Ayurveda recommends the use of Abrus seeds after the Shodhana process (detoxification). Objective: The current study was aimed at performing the Shodhana process, swedana (boiling) of Abrus precatorius seeds using water as a medium and to evaluate the anti-inflammatory potential of seed extract post detoxification. Materi...

  3. Clinical characteristics and causes of pruritus in cats

    OpenAIRE

    S. Hobi

    2011-01-01

    Hypersensitivity dermatitides (HD) are often suspected in cats. Cats with HD are reported to present with one or more of the following patterns: miliary dermatitis, eosinophilic dermatitis, self-induced symmetrical alopecia or head and/or neck excoriations. Previous reports on feline HD included small numbers of animals, took place in geographically restricted areas or did not compare these conditions with other causes of pruritus. The goal of the present study was to analyse 7...

  4. Hereditary vitamin D rickets: a case series in a family.

    Science.gov (United States)

    Surender, Kumar; Kochar, I P S; Ahmad, Ayesha; Kapoor, Meenal

    2014-11-01

    Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder characterized by end-organ resistance to 1α,25-dihydroxyvitamin D3 (1,25D3). Clinically, the syndrome is recognized by severe early onset rickets with bowing of the lower extremities, short stature, and often alopecia. Here, we report a case series on three siblings who had HVDRR with varied clinical findings.

  5. Utilizing electromagnetic radiation for hair growth: a critical review of phototrichogenesis.

    Science.gov (United States)

    Kalia, Sunil; Lui, Harvey

    2013-01-01

    Hair loss has a high prevalence in the general population and can have significant medical and psychological sequelae. Pattern hair loss and alopecia areata represent the major reasons patients present to dermatologists in relation to hair loss. Because conventional treatment options are generally incompletely effective, novel methods for hair grown induction are being developed. The role of using electromagnetic radiation, including low-level laser therapy for the management of hair loss through phototrichogenesis, is reviewed in this article.

  6. Cronkhite-Canada syndrome: case description

    Directory of Open Access Journals (Sweden)

    Andrea Da Porto

    2014-02-01

    Full Text Available We present the case of an 80-year old woman affected by the Cronkhite-Canada syndrome. This rare disease was described for the first time in 1955. It is characterized by the growth of multiple polyps in the gastroenteric tract, leading to diarrhea, alopecia, dystrophy of nails and hyper-pigmented skin. In this article, we describe the patient’s clinical picture and report the results of laboratory tests and imaging assessments.

  7. Food hypersensitivity in a cat.

    Science.gov (United States)

    Medleau, L; Latimer, K S; Duncan, J R

    1986-09-15

    Food hypersensitivity was diagnosed in a 4-year-old Siamese cat. Clinical signs included intense erythema, with alopecia, excoriations, erosions, and crusts involving the ventral portion of the abdomen, inguinal region, medial aspect of each thigh, and cranial and lateral aspects of all 4 limbs. The cat was intensely pruritic. Histologically, there was cutaneous mast cell hyperplasia and diffuse infiltration of eosinophils in the dermis. Blood eosinophilia also was found. Clinical signs resolved after exclusive feeding of a hypoallergenic diet.

  8. Generalized dermatitis associated with Malassezia overgrowth in cats: A report of six cases in France.

    Science.gov (United States)

    Crosaz, Odile; Legras, Audrey; Vilaplana-Grosso, Federico; Debeaupuits, Julien; Chermette, René; Hubert, Blaise; Guillot, Jacques

    2013-02-13

    We recently observed six cases of generalized dermatitis associated with Malassezia overgrowth in cats presented to the Veterinary College of Alfort, France. Elevated numbers of yeasts were observed in lesional skin by cytology and culture. Skin lesions occurred on the face, ventral neck, abdomen and ear canals and were characterized by some degree of alopecia, erythema and crusting. In most cases, pruritus was intense. The species M. pachydermatis was systematically isolated.

  9. Food hypersensitivity to lamb in a cat.

    Science.gov (United States)

    Reedy, L M

    1994-04-01

    Severe facial pruritus in a cat was caused by food hypersensitivity to lamb. The cat had been fed an exclusive diet of lamb for 2 years after it had been diagnosed to have food hypersensitivity to fish. Signs, including erythema, alopecia, and excoriations of the head and neck, were poorly responsive to corticosteroid administration, but resolved within a few weeks after removal of the suspected allergen.

  10. Male-pattern baldness susceptibility locus at 20p11.

    NARCIS (Netherlands)

    Richards, J.B.; Yuan, X.; Geller, F.; Waterworth, D.; Bataille, V.; Glass, D.; Song, K.; Waeber, G.; Vollenweider, P.; Aben, K.K.H.; Kiemeney, L.A.L.M.; Walters, B.; Soranzo, N.; Thorsteinsdottir, U.; Kong, A.; Rafnar, T.; Deloukas, P.; Sulem, P.; Stefansson, H.; Stefansson, K.; Spector, T.D.; Mooser, V.

    2008-01-01

    We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p1

  11. Nail abnormalities in patients with vitiligo

    OpenAIRE

    Topal, Ilteris Oguz; Gungor, Sule; Kocaturk, Ozgur Emek; Duman, Hatice; Durmuscan, Mustafa

    2016-01-01

    Abstract: Background: Vitiligo is an acquired pigmentary skin disorder affecting 0.1-4% of the general population. The nails may be affected in patients with an autoimmune disease such as psoriasis, and in those with alopecia areata. It has been suggested that nail abnormalities should be apparent in vitiligo patients. Objective: We sought to document the frequency and clinical presentation of nail abnormalities in vitiligo patients compared to healthy volunteers. We also examined the corre...

  12. FOXN1 deficient nude severe combined immunodeficiency

    OpenAIRE

    Rota, Ioanna A.; Dhalla, Fatima

    2017-01-01

    Nude severe combined immunodeficiency is a rare inherited disease caused by autosomal recessive loss-of-function mutations in FOXN1. This gene encodes a transcription factor essential for the development of the thymus, the primary lymphoid organ that supports T-cell development and selection. To date nine cases have been reported presenting with the clinical triad of absent thymus resulting in severe T-cell immunodeficiency, congenital alopecia universalis and nail dystrophy. Diagnosis relies...

  13. Doença granulomatosa sistêmica em bovinos no estado de Santa Catarina associada ao pastoreio de ervilhaca peluda (Vicia villosa

    Directory of Open Access Journals (Sweden)

    R.E Mendes

    2011-10-01

    Full Text Available Spontaneous intoxication in three dairy cows grazing pasture contaminated with Vicia villosa in two different farms was reported. Hyperthermia, skin alopecia and pruritus were the main clinical signs. Macroscopically, gray to white up to 5cm nodules were detected, especially in kidney and lymph nodes, which correspond to mild to severe multifocal granulomatous infiltrate. This is the first report of systemic granulomatous disease due to consumption of hairy vetch in the State of Santa Catarina, Brazil.

  14. Doença granulomatosa sistêmica em bovinos no estado de Santa Catarina associada ao pastoreio de ervilhaca peluda (Vicia villosa)

    OpenAIRE

    R.E Mendes; V Surkamp; D.C. Machado; Pilati,C

    2011-01-01

    Spontaneous intoxication in three dairy cows grazing pasture contaminated with Vicia villosa in two different farms was reported. Hyperthermia, skin alopecia and pruritus were the main clinical signs. Macroscopically, gray to white up to 5cm nodules were detected, especially in kidney and lymph nodes, which correspond to mild to severe multifocal granulomatous infiltrate. This is the first report of systemic granulomatous disease due to consumption of hairy vetch in the State of Santa Catarin...

  15. Perda pilosa por líquen plano pilar após transplante capilar: relato de dois casos e revisão da literatura Hair loss due to lichen planopilaris after hair transplantation: a report of two cases and a literature review

    Directory of Open Access Journals (Sweden)

    Márcio Rocha Crisóstomo

    2011-04-01

    Full Text Available Alopecia androgenética é tratada com frequência por meio de microtransplante capilar, téc nica em que os fios transplantados geralmente não caem, pois mantêm características da área doadora, mais resistente. O líquen plano pilar é uma alopecia cicatricial com permanente destruição pilosa. Este artigo relata dois casos de lesões compatíveis com líquen plano pilar em áreas receptora e doadora póstransplante. A dominância da área doadora foi aparentemente sobrepujada pelo líquen plano pilar, que deve ter gerado a queda dos fios. Relatos semelhantes são raros. À suspeita de líquen plano pilar, devese biopsiar o couro cabeludo e evitar o transplante durante a atividade da doença.Androgenetic alopecia is often treated by follicular unit transplantation, a technique that involves minimal risk of hair loss because of the more resistant nature of the donor area. Lichen planopilaris is a cicatricial alopecia that causes permanent destruction of hair follicles. We report two cases of post-transplantation lesions compatible with lichen planopilaris in both recipient and donor areas. The quality of the hair follicles in the donor area was apparently compromised by lichen planopilaris, the probable cause of hair loss. Similar reports are rare. When lichen planopilaris is suspected, a biopsy of the scalp must be performed to avoid transplantation during disease activity.

  16. Rare Occurrence of Drug Induced Subacute Cutaneous Lupus Erythematosus with Leflunomide Therapy

    OpenAIRE

    Singh, Harpreet; Sukhija, Gagandeep; Tanwar, Vikram; Arora, Sameer; Bhutani, Jaikrit

    2016-01-01

    Leflunomide is an immunomodulatory drug exhibiting anti-inflammatory, anti-proliferative and immunosuppressive effects. It has been widely used for treatment of active rheumatoid arthritis. Despite its good safety profile cutaneous side effects like alopecia, eczema, pruritis and dry skin have been reported with Leflunomide use. Skin ucleration, vasculitis, lichenoid drug rash and Subacute Cutaneous Lupus Erythematosus (SCLE) have been rarely reported with its use. A rare case of Leflunomide ...

  17. Updates in the understanding and treatments of skin & hair disorders in women of color

    OpenAIRE

    Christina N. Lawson, MD; Jasmine Hollinger, MD; Sumit Sethi, MD; Ife Rodney, MD; Rashmi Sarkar, MD; Ncoza Dlova, MBChB, FCDerm (SA); Valerie D. Callender, MD

    2015-01-01

    Skin of color comprises a diverse and expanding population of individuals. In particular, women of color represent an increasing subset of patients who frequently seek dermatologic care. Acne, melasma, and alopecia are among the most common skin disorders seen in this patient population. Understanding the differences in the basic science of skin and hair is imperative in addressing their unique needs. Despite the paucity of conclusive data on racial and ethnic differences in skin of color, ce...

  18. [Clinical features and genetics of the ichthyosis vulgaris group].

    Science.gov (United States)

    Traupe, H; Happle, R

    1980-12-11

    Combined application of clinical, genetic and histological criteria in general allows a definite diagnosis of autosomal dominant ichthyosis vulgaris and of X-linked recessive ichthyosis. For differential diagnosis, the following rare syndromes should be considered: ichthyosis bullosa: Refsum syndrome; Jung-Vogel syndrome; ichthyosis with corneal opacity, pili torti and alopecia; ichthyosis with deafness, pili torti and dental anomalies; and ichthyosis with hepatosplenomegaly and cerebellar degeneration.

  19. Polycystic ovary syndrome and hirsutism

    OpenAIRE

    Evliyaoğlu, Olcay

    2011-01-01

    Polycystic ovary syndrome is a multi factorial heterogenous disorder characterized by chronic anovulation and hyperandrogenism Diagnosis is based on clinical or laboratory evidence of nbsp; hyperandrogenism nbsp; For diagnosis at least two of the three Rotterdam criteria oligo anovulation clinical or biochemical signs of hyperandrogenism polycystic ovaries nbsp; should be ensured Clinical symptoms usually begin around menarche nbsp; Oligomenorrhea amenorrhea hirsutism acne alopecia can be ass...

  20. Finasteride and male breast cancer: Does the MHRA report show a link?

    Directory of Open Access Journals (Sweden)

    Niraj K Shenoy

    2010-01-01

    Full Text Available Finasteride is an important drug for the management of androgenetic alopecia. However, there are concerns about the possible side effects of the drug such as impotence. Recently stray reports have appeared about the occurrence of male breast carcinoma in patients who received the drug. These have been looked in to by Medicines and Health care products Regulatory Agency (MHRA. This article summarizes the MHRA report.