Sample records for alloy-ehi 432

  1. 7 CFR 58.432 - Catalase. (United States)


    ... Material § 58.432 Catalase. The catalase preparation shall be a stable, buffered solution, neutral in pH, having a potency of not less than 100 Keil units per milliliter. The source of the catalase, its... 7 Agriculture 3 2010-01-01 2010-01-01 false Catalase. 58.432 Section 58.432...

  2. 16 CFR 432.2 - Required disclosures. (United States)


    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Required disclosures. 432.2 Section 432.2... UTILIZED IN HOME ENTERTAINMENT PRODUCTS § 432.2 Required disclosures. (a) Whenever any direct or indirect... frequency response, in Hertz (Hz), for the rated power output required to be disclosed in paragraph (a)...

  3. 5 CFR 551.432 - Sleep time. (United States)


    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Sleep time. 551.432 Section 551.432... FAIR LABOR STANDARDS ACT Hours of Work Special Situations § 551.432 Sleep time. (a) Except as provided in paragraph (b) of this section, bona fide sleep time that fulfills the following conditions...

  4. Dicty_cDB: SHF432 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SH (Link to library) SHF432 (Link to dictyBase) - - - Contig-U15513-1 SHF432P (Link to Original site) SHF...432F 639 SHF432Z 648 SHF432P 1267 - - Show SHF432 Library SH (Link to library) Clone ID SHF...e URL Representative seq. ID SHF...432P (Link to Original site) Representative DNA sequence >SHF432 (SHF432Q) /CSM/SH/SHF4-B/SHF...GTDEDIIKLARDLTNTFGILLGDSDQPSQFSDVIFKVG DRKFFASKIMLVARSEYFKAMFTGSMKES--- ---iriywmkyyh*fvgki*isakhlnv*ii*klyqikkfqifldif*nqievkvshf

  5. 7 CFR 1980.432 - Environmental requirements. (United States)


    ... Environmental Information,” submitted by the borrower and the environmental impact assessment prepared by the... 7 Agriculture 14 2010-01-01 2009-01-01 true Environmental requirements. 1980.432 Section 1980.432 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL...

  6. Dicty_cDB: CHS432 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHS432 (Link to dictyBase) - - - Contig-U15902-1 CHS432P (Link to Original site) CHS4...32F 580 CHS432Z 768 CHS432P 1328 - - Show CHS432 Library CH (Link to library) Clone ID CHS4...e URL Representative seq. ID CHS4...32P (Link to Original site) Representative DNA sequence >CHS432 (CHS432Q) /CSM/CH/CHS4-B/CHS4...gymklffqtfmi*xyw ymkevxrnqfki*qk Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value CHS432 (CHS4

  7. Dicty_cDB: SLC432 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLC432 (Link to dictyBase) - - - Contig-U09715-1 | Contig-U16382-1 SLC...432P (Link to Original site) SLC432F 633 SLC432Z 188 SLC432P 821 - - Show SLC432 Library SL (Link to library) Clone ID SLC...15-1 | Contig-U16382-1 Original site URL Representative seq. ID SLC432P (Link to Original site) Representative DNA sequence >SLC432 (SLC...432Q) /CSM/SL/SLC4-B/SLC432Q.Seq.d/ ATTAAATTAAATAAAAAATAAAAATGGATGGTGAAGATGTTCAAGCTTTAGTTATTGATA

  8. Dicty_cDB: CHR432 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR432 (Link to dictyBase) - G21938 DDB0187836 Contig-U11942-1 CHR...432P (Link to Original site) CHR432F 688 CHR432Z 654 CHR432P 1322 - - Show CHR432 Library CH (Link to library) Clone ID CHR...Contig-U11942-1 Original site URL Representative seq. ID CHR432P (Link to Original site) Representative DNA sequence >CHR432 (CHR432Q) /CSM/CH/CHR...4-B/CHR432Q.Seq.d/ AATATTATAAAAATGGTTTTAACATTGAAAGAATTAATTAATAATATTTGTCAAACTAAA GATATAA

  9. 40 CFR 432.101 - Special definitions. (United States)


    ... animal and poultry trimmings, bones, meat scraps, dead animals, feathers and related usable by-products... 10 million pounds per year, produces meat meal, tankage, animal fats or oils, grease, and tallow, and... STANDARDS MEAT AND POULTRY PRODUCTS POINT SOURCE CATEGORY Renderers § 432.101 Special definitions. For...

  10. 7 CFR 28.432 - Middling Tinged Color. (United States)


    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Middling Tinged Color. 28.432 Section 28.432... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Standards Tinged Cotton § 28.432 Middling Tinged Color. Middling Tinged Color is color which is within the range represented by a set of samples in the custody...

  11. 47 CFR 24.432-24.444 - [Reserved (United States)


    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false 24.432-24.444 Section 24.432-24.444 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS SERVICES Interim Application, Licensing and Processing Rules for Narrowband PCS §§ 24.432-24.444...

  12. 46 CFR 154.432 - Expansion and contraction. (United States)


    ... 46 Shipping 5 2010-10-01 2010-10-01 false Expansion and contraction. 154.432 Section 154.432... Membrane Tanks § 154.432 Expansion and contraction. The support system of a membrane tank must allow for thermal and physical expansion and contraction of the tank. Semi-Membrane Tanks...

  13. 46 CFR 197.432 - Surface-supplied air diving. (United States)


    ... 46 Shipping 7 2010-10-01 2010-10-01 false Surface-supplied air diving. 197.432 Section 197.432... STANDARDS GENERAL PROVISIONS Commercial Diving Operations Specific Diving Mode Procedures § 197.432 Surface-supplied air diving. The diving supervisor shall insure that— (a) Surface-supplied air diving is...

  14. 14 CFR 43.2 - Records of overhaul and rebuilding. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Records of overhaul and rebuilding. 43.2 Section 43.2 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT MAINTENANCE, PREVENTIVE MAINTENANCE, REBUILDING, AND ALTERATION § 43.2 Records of overhaul and...

  15. 40 CFR 60.432 - Standard for volatile organic compounds. (United States)


    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standard for volatile organic compounds. 60.432 Section 60.432 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Graphic Arts Industry: Publication Rotogravure Printing § 60.432 Standard for volatile organic...

  16. 29 CFR 1926.432 - Environmental deterioration of equipment. (United States)


    ..., DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Electrical Safety-Related Maintenance and Environmental Considerations § 1926.432 Environmental deterioration of equipment....

  17. 20 CFR 410.432 - Cessation of disability. (United States)


    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Cessation of disability. 410.432 Section 410..., TITLE IV-BLACK LUNG BENEFITS (1969- ) Total Disability or Death Due to Pneumoconiosis § 410.432 Cessation of disability. (a) Where it has been determined that a miner is totally disabled under §...

  18. 40 CFR 52.432 - Significant deterioration of air quality. (United States)


    ... quality. 52.432 Section 52.432 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... deterioration of air quality. (a) The requirements of sections 160 through 165 of the Clean Air Act are not met... air quality. (b) Regulation for preventing significant deterioration of air quality. The provisions...

  19. 26 CFR 1.432-1.435 - [Reserved (United States)


    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false 1.432-1.435 Section 1.432-1.435 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Certain Stock Options §§...

  20. Uso de OK-432 em crianças com linfangioma OK-432 therapy for lymphangioma in children

    Directory of Open Access Journals (Sweden)

    Everaldo Ruiz Jr.


    Full Text Available OBJETIVO: Relatar a experiência no uso do OK-432 para tratamento de linfangiomas em crianças. MÉTODOS: Estudo retrospectivo de 19 crianças com linfangioma tratadas com OK-432 no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP, durante o período de 1999 a 2003. RESULTADOS: Todos os pacientes apresentaram alguma resposta ao OK-432, 12 pacientes apresentaram regressão total, sete apresentaram regressão parcial variando de 50% a 80%. Os pacientes apresentaram febre após a aplicação da droga com duração de 2 a 10 dias. Não se observaram cicatrizes após a aplicação do OK-432. CONCLUSÕES: A droga OK-432 é segura, eficaz e pode ser utilizada como primeira escolha no tratamento de pacientes com linfangiomas devido à excelente resposta, podendo tornar desnecessária a realização de cirurgia. Em pacientes com resposta parcial, podem ser realizadas novas aplicações de OK-432 ou cirurgia menos mutilante, devido à redução das dimensões da lesão.OBJECTIVE: To report the experience with OK-432 therapy for lymphangioma in children. METHODS: Retrospective study of 19 children with lymphangioma treated with OK-432 in Ribeirão Preto, state of São Paulo, Brazil, between 1999 and 2003. RESULTS: All patients presented response to OK-432, 12 had total shrinkage and seven had partial shrinkage varying from 50% to 80%. Patients had fever after injections of OK-432 for 2 to 10 days, no damage to the overlying skin was observed. CONCLUSION: OK-432 is safe, effective and can be used as primary choice of treatment of patients with lymphangiomas because of the excellent response. In these cases surgery should not be necessary. In patients with partial regression new injections of OK-432 must be used to shrink the lesion. Thereby safely surgery could be made.

  1. Linfangioma cervical: manejo terapéutico con OK-432 (Picibanil Cervical lymphangioma: therapeutic management with OK-432 (Picibanil

    Directory of Open Access Journals (Sweden)

    E. Valle Rodríguez


    Full Text Available Introducción: El linfangioma es una malformación del sistema linfático. El abordaje clásico ha sido la cirugía. El OK-432 (Picibanil tiene acción esclerosante y se está utilizando cómo primer escalón terapéutico. El objetivo es aportar un nuevo caso de linfangioma tratado con OK-432 y hacer una revisión de la literatura. Material y método: Aportamos un varón de 16 años con un linfangioma cervical macroquístico de 10 x 6 cm tratado con una dosis de OK-432. Resultados: A las 16 semanas del tratamiento, el tamaño del linfangioma era de 6 x 2 cm, siendo clínicamente inapreciable. Discusión: El tratamiento con OK-432 tiene una alta tasa de curación, con una baja tasa de recidiva y una fibrosis circunscrita a la lesión. En relación con la cirugía, se evitan cicatrices y posibles lesiones de estructuras vitales.Introduction: Lymphangioma is a malformation of the lymphatic system. The classic approach is surgery. OK-432 (Picibanil has sclerosing action and is being used as the first therapeutic step. The objective was to report a new case of lymphangioma treated with OK-432 and to review the literature. Material and method: We report the case of a 16-year-old man with a 10x6-cm macrocystic cervical lymphangioma treated with a dose of OK-432. Results: At 16 weeks of treatment, the size of the lymphangioma was 6x2 cm and it was clinically unappreciable. Discussion: OK-432 treatment has a high cure rate, low recurrence rate, and fibrosis circumscribed to the lesion. Compared to surgery, scars and possible harm to vital structures are avoided.

  2. Final data report for the instrumented fuel assembly (IFA)-432

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, E.R.; Cunningham, M.E.; Lanning, D.D.


    This report presents the in-reactor data collected during the irradiation of the six-rod instrumented fuel assembly (IFA)-432 in the Halden Boiling Water Reactor (HBWR) from June 1980 through June 1981. This Pacific Northwest Laboratory (PNL)-designed assembly was one of a series of US Nuclear Regulatory Commission (NRC)-sponsored tests to obtain data for the development and verification of steady-state fuel performance computer codes. IFA-432 operated from December 1975 until June 1981, when it was removed from the reactor. Two of the rods were removed for examination, and the assembly was reinserted in December 1981 to obtain additional data. Fuel centerline temperatures, cladding elongations, internal fuel rod pressures, and local powers at thermocouple positions were monitored during the irradiation of IFA-432; and the resulting data are presented in this report.

  3. 5 CFR 432.104 - Addressing unacceptable performance. (United States)


    ... PERFORMANCE BASED REDUCTION IN GRADE AND REMOVAL ACTIONS § 432.104 Addressing unacceptable performance. At any time during the performance appraisal cycle that an employee's performance is determined to be... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Addressing unacceptable performance....

  4. 48 CFR 432.703-3 - Contracts crossing fiscal years. (United States)


    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts crossing fiscal... GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 432.703-3 Contracts crossing fiscal... fiscal years so long as the total amount for such contracts is obligated in the year for which the...

  5. OK-432 sclerotherapy for benign cystic head and neck lesions

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chang Hyun; Rho, Myung Ho; Lee, Sang Wook [Masan Samsung Hospital, Masan (Korea, Republic of)


    To evaluate the efficacy of OK-432 solution for slerotheraphy of cystic lesions of the head and neck. Nineteen cystic lesions comprising ten plunging ranulas, three simple ranulas, three cystic lymphangiomas, one first branchial cleft cyst and two unknown supraclavicular cysts considered to be lymphangiomas were treated by sucking out as much liquid content as possible and then injecting the same volume of OK-432 solution under ultrasound guidance. Patients were followed up clinically and radiologically. Follow-up sonography or CT- performed after a mean interval of nine months showed total or near-total shrinkage of four plunging ranulas. However, six such lesions recurred in spite of more than one (mean, two) sclerotherapy sessions. In cases involving two simple ranulas at the floor of the mouth, failure resulted from extracystic leakage of OK-432 solution via the puncture site. Two unilocular cystic lymphangiomas completely regressed during the follow-up period (mean, seven months), but the multiocular type showed a 65% volume reduction after 12 months. A first branchial cleft cyst was markedly reduced in size, with only a small cystic portion remaining after eight months, follow-up. Two supraclavicular cysts with straw-color fluid did not respond to sclerotherapy. OK-432 sclerotherapy of macrocystic lymphangiomas is an effective and promising alternative to surgery. For other cysts, however, including plunging ranula, efficacy, varied, and 64% of such lesions recurred.

  6. 27 CFR 4.32a - Voluntary disclosure of major food allergens. (United States)


    ... major food allergens. 4.32a Section 4.32a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... Requirements for Wine § 4.32a Voluntary disclosure of major food allergens. (a) Definitions. For purposes of this section the following terms have the meanings indicated. (1) Major food allergen. Major...

  7. 48 CFR 432.006 - Reduction or suspension of contract payments upon finding of fraud. (United States)


    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Reduction or suspension of contract payments upon finding of fraud. 432.006 Section 432.006 Federal Acquisition Regulations System... of contract payments upon finding of fraud....

  8. 42 CFR 432.31 - Training and use of subprofessional staff. (United States)


    ... 42 Public Health 4 2010-10-01 2010-10-01 false Training and use of subprofessional staff. 432.31...; Subprofessional and Volunteer Programs § 432.31 Training and use of subprofessional staff. (a) State plan requirement. A State plan must provide for the training and effective use of subprofessional staff...

  9. Asiago eclipsing binaries program. I. V432 Aur

    CERN Document Server

    Siviero, A; Sordo, R; Dallaporta, S; Zwitter, T; Marrese, P M; Milone, E F


    The orbit and physical parameters of the previously unsolved eclipsing binary V432 Aur, discovered by Hipparcos, have been derived with errors better than 1% from extensive Echelle spectroscopy and B, V photometry. Synthetic spectral analysis of both components has been performed, yielding T_eff and log g in close agreement with the orbital solution, a metallicity [Z/Z_sun]=-0.6 and rotational synchronization for both components. Direct comparison on the theoretical L, T_eff plane with the Padova evolutionary tracks and isochrones for the masses of the two components (1.22 and 1.08 M_sun) provides a perfect match and a 3.75 Gyr age. The more massive and cooler component is approaching the base of the giant branch and displays a delta-Sct pulsation activity with an amplitude of Delta V = 0.075 mag and Delta rad.vel. = 1.5 km/sec. With a T_eff = 6080 K it is one of the coolest delta-Sct known, falling well to the red of the instability strip edge. Orbital modeling reveals a large and bright surface spot on it. ...

  10. Biodegradation of Mexel 432 By Bacteria From the Seine River; Biodegradation du Mexel 432 par des bacteries de la Seine

    Energy Technology Data Exchange (ETDEWEB)

    Allonier, A.S.; Khalanski, M.


    This report deals with a study of the biodegradation of a filmogenic organic product (Mexel 432) usable in the fight against corrosion, scale and fouling, presenting a certain interest in the research of processes enabling a functional and environmental efficiency for the cooling systems of thermal power stations. The study of the degradation of this product is followed by a global colorimetric method. It shows that the product is stable on the long-term in demineralized water. On the other hand, its rate of disappearance in river waters is significant (50 % in 2 or 3 days). In this phenomenon of disappearance, biodegradation seems to play a part. Some bacteria from the natural environment (river Seine) have been isolated. Two of them seem to play a significant part, since they can degrade the product in three weeks. During the degradation, the amines with long chains (more than six carbons) of the Mexel, measured by the colorimetric method, disappear. The other compounds generated by the biodegradation process are not identified. (authors). 16 refs.

  11. The CYP1B1 Leu432Val polymorphism and risk of urinary system cancers. (United States)

    Liu, Yi; Lin, Chang-sheng; Zhang, Ai-min; Song, Hua; Fan, Chang-chun


    The cytochrome P450 1B1 (CYP1B1) gene plays a key role in the metabolism of various carcinogens. The CYP1B1 Leu432Val polymorphism leads to leucine to valine substitution at codon 432. A lot of studies have shown that the CYP1B1 Leu432Val polymorphism was associated with urinary system cancers, especially prostate cancer. However, the results were still inconclusive. In this meta-analysis, by searching online databases and references of related reviews, we identified 17 eligible studies to assess the relationship between CYP1B1 Leu432Val polymorphism and urinary system cancers, including 7,783 cancer cases and 7,238 controls. By pooling all eligible studies, we found that the CYP1B1 Leu432Val polymorphism was not associated with overall urinary system cancers. However, in subgroup analyses, we found that the variant 432Val allele significantly increased the risk of prostate cancer (Val vs. Leu, odds ratio (OR) = 1.064, 95% confidence interval (CI) 0.981-1.154; Pheterogeneity = 0.002), while no association was found for bladder cancer (Val vs. Leu, OR = 0.942, 95% CI 0.853-1.041; Pheterogeneity = 0.504). No evidence of publication bias was found (Begg's test, P = 0.053; Egger's test, P = 0.073). In conclusion, based on 17 eligible studies, we found that the CYP1B1 Leu432Val polymorphism was associated with an increased risk of prostate cancer, while no association of bladder cancer was observed.

  12. Plunging ranula intruding into the parapharyngeal space treated with OK-432. (United States)

    Kinoshita, Makoto; Kida, Wataru; Nakahara, Haruka


    We report a very rare case of a plunging ranula extending into the parapharyngeal space, which was treated successfully with OK-432. A 27-year-old woman presented with a 4-month history of right submandibular swelling. Based on computed tomography and magnetic resonance imaging findings, we established a diagnosis of plunging ranula intruding into the parapharyngeal space. The patient was treated with an intracystic OK-432 injection that was administered under ultrasonographic guidance. At 6 weeks after the injection, computed tomography showed complete disappearance of the cystic mass. No recurrence was noted during the 10-month follow-up.

  13. Experimental intraperitoneal infusion of OK-432 in rats: Evaluation of peritoneal complications and pathology

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dong Wook [Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of); Kim, Hak Jin, E-mail: [Department of Radiology, Pusan National University Hospital, Pusan National University College of Medicine, Medical Research Institute, Busan (Korea, Republic of); Lee, Jun Woo [Department of Radiology, Pusan National University Hospital, Pusan National University College of Medicine, Medical Research Institute, Busan (Korea, Republic of)


    Purpose: OK-432 is known to be a potent sclerosant of cystic lesions. The purpose of this study was to evaluate both its safety and pathologic effects after the infusion of OK-432 into the peritoneal cavity of rats. Materials and methods: Twenty male rats were used in this study. Twelve rats were infused intraperitoneally with 0.2 Klinishe Einheit of OK-432 melted in 2 mL of normal saline (group 1: the treated group); four rats each were infused intraperitoneally with 0.5 mL of 99% ethanol (group 2) and normal saline (group 3), and served as the control groups. An abdominal ultrasonographic examination was performed both before and after the infusions in all rats. Three rats in group 1 and one rat in each of groups 2 and 3 were sacrificed each week following the infusion. Gross and microscopic evaluations of the peritoneum and abdominal cavity were performed on each rat. Results: In group 1, the abdomen was clear on gross inspection and the peritoneum was unremarkable on microscopic examination. In group 2, mild-to-moderate peritoneal adhesions were revealed grossly, and inflammation and fibrosis of the peritoneum were demonstrated microscopically. In group 3, no specific abnormalities were noted on gross or microscopic examinations. Conclusion: Leakage or abnormal infusion of OK-432 solution into the peritoneal cavity during sclerotherapy of intra-abdominal or retroperitoneal cystic lesions does not result in any significant complications.

  14. 432例药品不良反应报告分析%Analysis of 432 cases of adverse drug reactions

    Institute of Scientific and Technical Information of China (English)

    张笑颖; 叶银梅


    [AbstrAct]Objective:To investigate the characteristics and patterns of the adverse drug reactions (ADRs) in our hospital, and provide references for rational drug use.Methods:A total of 432 ADR reports in our hospital from 2014 to 2015 were collected retrospectively. The data in respect of age and gender of patients, categories of drugs, route of administration, systems and organs involved in ADR were analyzed statistically.results:The ADR occurred mostly in elderly patients and children. Among the 432 cases, 136 kinds of drugs were involved, 171 cases were induced by 32 anti-infective drugs; the ADR was mostly induced by intravenously administered drugs (289 cases) and manifested mainly as lesions of skin and its appendants, damage of digestive system and nervous system.conclusion: On the basis of the concept of patient-centered services and attention of leadership, the work of ADR monitoring was advancing all the time by taking several measures, for promoting patient's medication safety and effectiveness.%目的:探讨我院药品不良反应发生的特点及规律,为临床合理用药提供参考。方法:采用回顾性分析方法,收集我院2014–2015年432例ADR监测报告,对患者性别、年龄、药品种类、给药途径、累及系统/器官及主要临床表现等进行分析。结果:432例ADR中,老年人、儿童患者ADR发生率较高;引起ADR共涉及药物136种,其中抗感染药物32种,共引发ADR 171例次;引发ADR的给药途径以静脉给药为主,共计289例;ADR累及系统/器官方面,皮肤及其附件、消化系统、神经系统损害等发生率高。结论:我院ADR监测工作在以患者为中心的基础上,监管部门高度重视,多措并举,ADR监测水平逐步提高,促进了患者用药的安全、有效。

  15. OK432优化的内皮细胞疫苗抗小鼠乳腺癌作用研究%Anti-tumor effects of OK432 optimized umbilical vein endothelial cell vaccine in murine breast cancer

    Institute of Scientific and Technical Information of China (English)

    徐茂磊; 周玲; 杨小平


    目的:探讨 OK432优化的人脐静脉内皮细胞( HU-VECs)疫苗对小鼠EAC乳腺癌的生长抑制作用。方法体外培养HUVECs,与佐剂OK432混合,制备HUVECs-OK432疫苗,以小鼠 EAC 乳腺癌皮下移植瘤模型考查 HUVECs-OK432疫苗的抗肿瘤效应,并通过ELISA、脾细胞增殖及细胞毒性T淋巴细胞( CTL)杀伤实验检测疫苗免疫后体液及细胞免疫应答水平。结果在预防性免疫中, HUVECs-OK432疫苗可以明显抑制EAC乳腺癌生长;HUVECs-OK432疫苗诱导小鼠产生了高滴度的特异性 HUVEC 抗体;HU-VECs-OK432疫苗能有效刺激免疫小鼠脾淋巴细胞的增殖;HUVECs-OK432组小鼠脾细胞诱导产生了明显的靶向HU-VEC细胞的CTL杀伤作用。结论 HUVECs-OK432疫苗可以有效诱导机体产生靶向HUVEC的特异性体液及细胞免疫应答,从而有效抑制了小鼠EAC乳腺癌的生长。%Aim To investigate the anti-EAC breast cancer effects of viable human umbilical vein endothe-lial cells ( HUVECs) vaccine. Methods Subconflu-ent HUVECs were mixed with OK432 to prepare HU-VECs-OK432 vaccine, and the anti-tumor efficacy of HUVECs-OK432 was investigated using a subcutaneous tumor model of EAC breast cancer. ELISA, splenic lymphocyte proliferation assay and cytotoxic T lympho-cytes ( CTL ) killing assay were adopted to detect the humoral and cellular immune responses after HUVECs-OK432 immunization. Results HUVECs-OK432 im-munization significantly inhibited the growth of EAC tumor in mice in the prophylactic procedures. High ti-ter of anti-HUVEC antibody was elicited by HUVECs-OK432 immunization. The proliferation activity of splenocytes from mice immunized with HUVECs-OK432 was significantly increased. T lymphocytes iso-lated from HUVECs-OK432-immunized mice were dose dependently killing HUVECs in vitro. Conclusion Strong humoral and cellular immune responses targeting HUVEC are elicited by HUVECs-OK432 immuniza-tion, which results in a significant inhibition on the growth

  16. Fibrinogen variant B[beta]D432A has normal polymerization but does not bind knob 'B'

    Energy Technology Data Exchange (ETDEWEB)

    Bowley, Sheryl R.; Lord, Susan T.; (UNC)


    Fibrinogen residue B{beta}432Asp is part of hole 'b' that interacts with knob 'B,' whose sequence starts with Gly-His-Arg-Pro-amide (GHRP). Because previous studies showed B{beta}D432A has normal polymerization, we hypothesized that B{beta}432Asp is not critical for knob 'B' binding and that new knob-hole interactions would compensate for the loss of this Asp residue. To test this hypothesis, we solved the crystal structure of fragment D from B{beta}D432A. Surprisingly, the structure (rfD-B{beta}D432A+GH) showed the peptide GHRP was not bound to hole 'b.' We then re-evaluated the polymerization of this variant by examining clot turbidity, clot structure, and the rate of FXIIIa cross-linking. The turbidity and the rate of - dimer formation for B{beta}D432A were indistinguishable compared with normal fibrinogen. Scanning electron microscopy showed no significant differences between the clots of B{beta}D432A and normal, but the thrombin-derived clots had thicker fibers than clots obtained from batroxobin, suggesting that cleavage of FpB is more important than 'B:b' interactions. We conclude that hole 'b' and 'B:b' knob-hole binding per se have no influence on fibrin polymerization.

  17. An Analysis on the Sizing Device Structure and Sizing Quality of Sucker S432 Sizing Machine%祖克S432型浆纱机上浆装置结构及浆纱质量分析

    Institute of Scientific and Technical Information of China (English)

    李西侠; 沈艳琴



  18. OK432 (picibanil) efficacy in an adult with cystic cervical lymphangioma. A case report. (United States)

    Alonso, Juan; Barbier, Luis; Alvarez, Julio; Romo, Laura; Martín, Jesús C; Arteagoitia, Iciar; Santamaría, Joseba


    Cervical cystic lymphangioma (CCL) is a rare and benign tumour involving congenital and cystic abnormalities derived from lymphatic vessels. The most accepted treatment continues to be surgical excision. However, when this infiltrates vital neurovascular neck structures, complete excision is difficult and if only partial, the recurrence rate is very high. The most frequently used alternative treatment is to inject sclerosants into the lesion. The use of these techniques has reported good results in children; however, there are few references thereof with regard to adults. We are reporting on a cervical cystic lymphangioma in a male aged 22, treated with an intra-lesion injection of 20 cc with 0.01 mg/cc dilution of OK-432 (picibanil) in physiological serum. Sole complications were fever and local reaction where the solution was injected. One month after treatment the lymphangioma had totally remitted and sixteen months later continues in remittance.

  19. Application of VE432 system operation with Scorpion seismic recording system%VE432电控箱体如何与Scorpion地震仪器配套使用

    Institute of Scientific and Technical Information of China (English)



    为了实现VE432震源电控箱体与Scorpion地震勘探仪器的配套应用,本文对VE432 Standalone软件的安装,补丁的装载、设置及其与Scorpion仪器的联机、设置,都详细进行了说明,并对震源激发和数据采集的同步验证进行了理论分析,实现了Scorpion系统控制装有VE432箱体的震源进行野外施工的采集作业。%This paper describes the application of Sercel VE432 system operation with Inova Scorpion seismic system for exploration including the procedures of install software to parameters setting in detail. Theoretical analysis and practical verification of acquisition synchronization are also introduced in this paper.

  20. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics (United States)

    Wu, Ann C.; Himes, Blanca E.; Lasky-Su, Jessica; Litonjua, Augusto; Peters, Stephen P.; Lima, John; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Qiu, Weiliang; Weiss, Scott T.; Tantisira, Kelan


    Background Single nucleotide polymorphisms (SNPs) influence a patient's response to inhaled corticosteroids and β2-agonists, and the effect of treatment with inhaled corticosteroids is synergistic with the effect of β2-agonists. We hypothesized that use of inhaled corticosteroids could influence the effect of SNPs associated with bronchodilator response. Objective To assess whether, among asthma subjects, the association of SNPs with bronchodilator response is different between those treated with inhaled corticosteroids vs. those on placebo. Methods A genome-wide association analysis was conducted using 581 white subjects from the Childhood Asthma Management Program (CAMP). Using data for 449,540 SNPs, we conducted a gene by environment analysis in PLINK with inhaled corticosteroid treatment as the environmental exposure and bronchodilator response as the outcome measure. We attempted to replicate the top 12 SNPs in the Leukotriene Modifier Or Corticosteroid or Corticosteroid-Salmeterol (LOCCS) Trial. Results The combined P-value for the CAMP and LOCCS populations was 4.81E-08 for rs3752120, which is located in the zinc finger protein gene ZNF432, and has unknown function. Conclusions Inhaled corticosteroids appear to modulate the association of bronchodilator response with variant(s) in the ZNF432 gene among adults and children with asthma. Clinical Implications Clinicians who treat asthma patients with inhaled corticosteroids should be aware that the patient's genetic makeup likely influences response as measured in lung function. Capsule Summary Our study suggests that inhaled corticosteroids could influence the effect of multiple SNPs associated with bronchodilator response across the genome. PMID:24280104

  1. 11 CFR 105.1 - Place of filing; House candidates and their authorized committees (2 U.S.C. 432(g)(1)). (United States)


    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Place of filing; House candidates and their authorized committees (2 U.S.C. 432(g)(1)). 105.1 Section 105.1 Federal Elections FEDERAL ELECTION COMMISSION GENERAL DOCUMENT FILING (2 U.S.C. 432(g)) § 105.1 Place of filing; House candidates and their...

  2. GM338电台在VE432可控震源上的应用

    Institute of Scientific and Technical Information of China (English)



    VE432可控震源控制系统原配电台为GM300,因使用环境恶劣、使用年限长,电台性能下降,故障率上升。因此,决定用性能稳定、抗振动、耐高温的同系列的新型电台GM338代替GM300。但GM338电台直接代替GM300电台与VE432可控震源控制系统匹配使用,必须进行相应的改进。本文详细地分析了GM338电台的电路特点,介绍了具体的改进方法。%The original radio type for VE432 control system is GM300. The poor conditions and long service life resulted in increasing failure rates. Another new type radio, GM338 with stable performance and anti-vibration function as well as high working temperature, is often adopted to replace GM300. To match with VE432 well, some transfor- mation should be done to GM338 and GM300. This paper analyzes the circuit characteristics of GM338 radio and in- troduces the detailed method for transformation.

  3. 11 CFR 104.18 - Electronic filing of reports (2 U.S.C. 432(d) and 434(a)(11)). (United States)


    ... specifications and can be read by the Commission's computer system. Each report submitted in an electronic format... 11 Federal Elections 1 2010-01-01 2010-01-01 false Electronic filing of reports (2 U.S.C. 432(d) and 434(a)(11)). 104.18 Section 104.18 Federal Elections FEDERAL ELECTION COMMISSION GENERAL...

  4. 17 CFR 4.32 - Trading on a Registered Derivatives Transaction Execution Facility for Non-Institutional Customers. (United States)


    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Trading on a Registered... Securities Exchanges COMMODITY FUTURES TRADING COMMISSION COMMODITY POOL OPERATORS AND COMMODITY TRADING ADVISORS Commodity Trading Advisors § 4.32 Trading on a Registered Derivatives Transaction...

  5. Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery. (United States)

    West, Emma; Morgan, Ruth; Scott, Karen; Merrick, Alison; Lubenko, Anatole; Pawson, David; Selby, Peter; Hatfield, Paul; Prestwich, Robin; Fraser, Sheila; Eves, David; Anthoney, Alan; Twelves, Chris; Beirne, Debbie; Patel, Poulam; O'Donnell, Dearbhaile; Watt, Suzanne; Waller, Michael; Dietz, Allan; Robinson, Philip; Melcher, Alan


    Dendritic cells (DC) are under intense preclinical and early clinical evaluation for the immunotherapy of cancer. However, the optimal culture conditions and route of delivery for DC vaccination have not been established. Here we describe the first human application of DC matured with the bacterial agent OK432 (OK-DC), using a short-term serum-free culture protocol, which generates mature DC from CD14+ precursors after 5 days. These cells were prepared within the framework of a National Blood Service facility, demonstrating that DC represent a product which is potentially deliverable alongside current standardized cell therapies within the UK National Health Service. In vitro analysis confirmed that OK-DC were mature, secreted tumor necrosis factor-alpha, interleukin-6, and interleukin-12, and stimulated both T cell and natural killer cell function. To explore effective delivery of OK-DC to lymph nodes, we performed an initial clinical tracking study of radioactively labeled, unpulsed OK-DC after intralymphatic injection into the dorsum of the foot. We showed that injected DC rapidly localized to ipsilateral pelvic lymph nodes, but did not disseminate to more distant nodes over a 48-hour period. There was no significant toxicity associated with OK-DC delivery. These results show that OK-DC are suitable for clinical use, and that intralymphatic delivery is feasible for localizing cells to sites where optimal priming of innate and adaptive antitumor immunity is likely to occur.

  6. Gene polymorphism of CYP1B1 Leu 432 Val in Guangxi Zhuang population%广西壮族人群CYP1B1基因Leu432 Va1多态性分析

    Institute of Scientific and Technical Information of China (English)

    廖长秀; 李曙波; 唐卫东; 何昀; 黎为能


    Objective To investigate hereditary character of cytochrome P450 1B1 (CYP1B1) codon 432 among Guangxi Zhuang population. Methods Gene polymorphism of CYP1B1 codon 432 was detected by di-allele-specific-amplification with artificially modified primers (diASA-AMP) in 288 healthy Guangxi Zhuang people. The genotype frequencies of CYP1B1 codon 432 in the population were compared with other populations in China,other countries and regions. Results The frequency of allele C in CYP1B1 gene Leu 432 Val was high in both female(89. 1% ) and male population(9l.4%).The prevalence rates of CYP1B1 Leu 432 Val genotypes CC,CG,and GG were 78. 3% ,21.3%, and 0 in the female population,and those in male population were 83. 6% ,15. 6% ,and 0. 8% .respectively. There was no difference between female and male population in allele and genotype frequency of CYP1B1 Leu 432 Val in the population. The frequency of genotype distribution in the population had no obvious differences compared with Korea popoula-tion.but had significant differences compared with other populations in Jiangsu,Shanghai,Sichuan(P <0.05) ,Japan, India,Poland,Nigeria, and America(P < 0. 01). Conclusion Gene polymorphism of CYP1B1 in codon 432 has no gender difference in Guangxi Zhuang population,and the distributions of the gene polymorphism in the population are different from those in other regions of China and other countries.%目的 研究CYP1B1第432密码子在广西壮族人群中遗传特征,为进一步研究CYP1B1基因多态性与疾病的发生易感性奠定基础.方法 采用人工修饰双等位基因特异性引物扩增法(diASA-AMP)技术对288名广西壮族正常成人进行CYP1B1 Leu 432 Va1基因分型,探讨性别间差异及与国内外其他人群分布频率差异.结果 广西壮族女性和男性人群CYP1B1 Leu 432 Va1均以C等位基因为主,分别为89.1%和91.4%;CC野生纯合子型、CG杂合子型和GG突变纯合型在女性人群中分别为78.3%、21.3%和0,

  7. CYP1B1 Leu432Val polymorphism and colorectal cancer risk among Caucasians: a meta-analysis. (United States)

    Xie, Yong; Liu, Guo-Qing; Miao, Xiong-Ying; Liu, Yi; Zhou, Wei; Zhong, De-Wu


    Studies investigating the association between cytochrome P450 1B1 (CYP1B1) Leu432Val (432 C/G, rs1056836) polymorphism and colorectal cancer (CRC) risk report conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) for CYP1B1 polymorphism and CRC were calculated in a fixed-effects model and a random-effects model when appropriate. The pooled ORs were performed for co-dominant model (GG vs. CC, GC vs. CC), dominant model (GG + GC vs. CC), and recessive model (GG vs. GC + CC). This meta-analysis included ten case-control studies, which included 8,466 CRC cases and 9,301 controls. Overall, the variant genotypes (GG and GC) of the 432 C/G were not associated with CRC risk when compared with the wild-type CC homozygote (GG vs. CC, OR = 1.01, 95% CI = 0.93-1.10; GC vs. CC, OR = 0.97, 95% CI = 0.90-1.04), without any between-study heterogeneity. Similarly, no associations were found in the dominant and recessive models (dominant model, OR = 0.98, 95% CI = 0.92-1.05; recessive model, OR = 1.03, 95% CI = 0.96-1.11). Limiting the analysis to the studies within Hardy-Weinberg equilibrium, the results were persistent and robust. When stratifying for country, matched control and source of controls, no evidence of significant association was observed in any subgroup. No publication bias was found in the present study. No association is found between the CYP1B1 Leu432Val polymorphism and risk of CRC among Caucasians.

  8. OK-432 reduces mortality and bacterial translocation in irradiated and granulocyte-colony stimulating factor (G-CSF)-treated mice

    Energy Technology Data Exchange (ETDEWEB)

    Nose, Masako; Uzawa, Akiko; Ogyu, Toshiaki [National Inst. of Radiological Sciences, Chiba (Japan); Suzuki, Gen


    Acute radiation induces bacterial translocation from the gut, followed by systemic infection and sepsis. In order to reduce the mortality after acute whole body irradiation, it is essential to control bacterial translocation. In this study, we established a bacterial translocation assay as a sensitive method to detect minor mucosal injury by radiation. By utilizing this assay, we evaluated the adverse effects, if any, of hematopoietic reagents on the mucosal integrity in the respiratory and gastro-intestinal tracts. Bacterial translocation to the liver and spleen occurred after whole-body irradiation if the dose exceeded 6 Gy. The administration of G-CSF unexpectedly increased the bacterial translocation in 8 Gy-irradiated mice. The pharmaceutical preparation of low-virulent Streptococcus pyogenes, OK-432, significantly reduced the endotoxin levels in peripheral blood without any reduction of bacterial translocation. A combined treatment with G-CSF and OK-432 decreased bacterial translocation and prevented death. This result indicates that the early administration of G-CSF has an adverse effect on bacterial translocation, and that a combined treatment of G-CSF and OK-432 attenuates the adverse effect of G-CSF and improves the survival rate after acute irradiation. (author)

  9. Effect of OK-432 combined UFT in patients with stage III non-small cell lung cancer treated by radiotherapy. A randomized prospective study

    Energy Technology Data Exchange (ETDEWEB)

    Jingu, Kenichi [Fukuoka Univ. (Japan). School of Medicine; Ohmagari, Junichi; Masuda, Kouji [and others


    Distant metastasis and local recurrence are the causes of poor treatment results of unresectable non-small cell lung cancer patients. Inhibition of repair from radiation damage in tumors and distant metastases may improve the survival rate. Some authors of this paper previously reported that tegafur combined with OK-432 significantly improved the survival rate in these patients. We conducted a prospective randomized trial using UFT (mixed preparation of tegafur and uracil) with or without OK-432, after radiotherapy in these patients, to assess the effect of OK-432 on survival rate, the duration of continued response by previous treatment, and the effect on leucopenia due to UFT. However, unexpected results were obtained. OK-432 did not prolong response duration, did not improve the survival rate, and did not inhibit the leucopenia due to UFT. (author)

  10. GA308型与祖克S432型浆纱机操作特点对比%Comparison of Operation Features with GA308 and Sucker S432 Sizing Machine

    Institute of Scientific and Technical Information of China (English)




  11. The CYP1B1 Leu432Val polymorphism contributes to lung cancer risk: evidence from 6501 subjects. (United States)

    Chen, Bo; Qiu, Li-Xin; Li, Yan; Xu, Wei; Wang, Xue-Li; Zhao, Wei-Hong; Wu, Jian-Qing


    The polymorphism of cytochrome P4501B1 (CYP1B1) codon 432 (rs1056836, CYP1B1*3, or Leu432Val) is thought to have a significant effect on lung cancer risk, but the results are inconsistent. In this meta-analysis, we assessed 9 published studies involving 6501 subjects that investigated the association between the CYP1B1 codon 432 polymorphism and risk of lung cancer. Overall, the CYP1B1 Leu/Val and Val/Val-variant genotypes were associated with a significantly increased risk of lung cancer in different genetic models (heterozygote comparison: OR=1.22; 95% CI=1.02-1.45, P(heterogeneity)=0.068; homozygote comparison: OR=1.41; 95% CI=1.08-1.85, P(heterogeneity)=0.071; dominant model comparison: OR=1.26; 95% CI=1.04-1.51, P(heterogeneity)=0.019; and recessive model comparison: OR=1.17; 95% CI=1.02-1.34, P(heterogeneity)=0.429). In the stratified analysis by ethnicity, significantly increased risks were found among Caucasians for Leu/Val vs Leu/Leu (OR=1.30; 95% CI=1.03-1.64; P(heterogeneity)=0.092), and dominant model (OR=1.35; 95% CI=1.03-1.77; P(heterogeneity)=0.015). However, no significant associations were found in both Europeans and African-Americans for all genetic models. In the subgroup analyses by smoking status, a significantly increased risk of lung cancer was found among smokers (dominant model: OR=1.46; 95% CI=1.08-1.83; P(heterogeneity)=0.175). However, we did not find any statistically significant association by subgroup analyses of pathological type. This meta-analysis suggests that the CYP1B1 Val allele is a low-penetrant risk factor for developing lung cancer.

  12. O uso de Picibanil (OK-432 no tratamento do linfangioma de cabeça e pescoço

    Directory of Open Access Journals (Sweden)

    Mello-Filho Francisco V.


    Full Text Available Introdução e Objetivo: O Linfangioma Cérvico-Facial (LCF é geralmente um tumor volumoso, envolvendo estruturas importantes da face e do pescoço. A terapia habitualmente recomendada é a retirada cirúrgica, porém, esta é geralmente seguida de seqüelas importantes, causando deformidade da região. Com o objetivo de avaliarmos uma terapêutica alternativa, analisamos a eficiência do Picibanil (OK 432 no tratamento de LCF em crianças. Forma de Estudo: Clínico retrospectivo. Material e Método: Estudo retrospectivo de seis crianças com diagnóstico de LCF tratadas com OK-432 no HCFMRP-USP no período de 1997 a 2001. Foram analisadas as seguintes características dos LCF: dimensões, tipos de cistos e volume aspirado. Avaliamos, também, o número de aplicações de OK 432 com os respectivos intervalos de tempo utilizados, sua evolução, intercorrências e o resultado final do tratamento. Resultados: Os LCFs apresentavam de oito a 15cm em seu maior diâmetro, na ocasião da primeira consulta, sendo o tipo de cisto mais freqüentemente encontrado o tipo macro cisto. O volume de liquido aspirado variou de dois a 60 ml e o número de aplicações de uma a cinco vezes em intervalos variáveis de um mês a um ano. Em todos os pacientes ocorreu regressão da massa tumoral, sendo que em três houve o desaparecimento total do LCF. A única intercorrência observada foi febre em media de 38.2º C em todos pacientes. Conclusão: O OK 432 é uma droga segura, eficaz e que pode ser utilizada como medida de primeira escolha no tratamento do LCF.

  13. Characterization of leucocin B-KM432Bz from Leuconostoc pseudomesenteroides isolated from boza, and comparison of its efficiency to pediocin PA-1.

    Directory of Open Access Journals (Sweden)

    Kahina Maya Makhloufi

    Full Text Available A bacteriocin-producing bacterium was isolated from boza and identified as Leuconostoc pseudomesenteroides KM432Bz. The antimicrobial peptide was purified and shown to be identical to other class IIa bacteriocins: leucocin A from Leuconostoc gelidum UAL-187 and Leuconostoc pseudomesenteroides QU15 and leucocin B from Leuconostoc carnosum Ta11a. The bacteriocin was named leucocin B-KM432Bz. Leucocin B-KM432Bz gene cluster encodes the bacteriocin precursor (lcnB, the immunity protein (lcnI and the dedicated export machinery (lcnD and lcnE. A gene of unknown and non-essential function (lcnC, which is interrupted by an insertion sequence of the IS30 family, is localized between lcnB and lcnD. The activity of leucocin B-KM432Bz requires subunit C of the EII(t Man mannose permease, which is the receptor for entry into target cells. The determination of the minimum inhibitory concentrations revealed the lowest values for leucocin B-KM432Bz over Listeria strains, with 4 to 32 fold better efficiency than pediocin PA-1.

  14. The development of speaking fluency: The 4/3/2 technique for the EFL learners in China

    Directory of Open Access Journals (Sweden)

    Yingjie Ian Jack Yang


    Full Text Available EFL teaching is gradually changed from a traditional grammar-based model to a communicative language teaching approach in China. So, there is a variety of methodologies to help the Chinese EFL learners to practice their speaking skills. Lack of speaking fluency practice, sometimes, is not sufficient to maintain a communicative task in EFL class. This paper examines previous studies and researches in fluency development: to point out the importance of speaking fluency; to outline a 4/3/2 method adapting in the EFL class; to implement retrieval strategy to cultivate a long-term practice and to prove the fluency improvements in class will be beneficial in real-life conversation.

  15. Mature dendritic cells generated from patient-derived peripheral blood monocytes in one-step culture using streptococcal preparation OK-432 exert an enhanced antigen-presenting capacity. (United States)

    Naito, Kei; Ueda, Yuji; Itoh, Tsuyoshi; Fuji, Nobuaki; Shimizu, Keiji; Yano, Yutaro; Yamamoto, Yoshiki; Imura, Kenichiro; Kohara, Junji; Iwamoto, Arihiro; Shiozaki, Atsushi; Tamai, Hidemasa; Shimizu, Takeshi; Mazda, Osam; Yamagishi, Hisakazu


    Dendritic cells (DCs) have been shown to be potent in inducing cytotoxic T cell (CTL) response leading to the efficient anti-tumor effect in active immunotherapy. Myeloid DCs are conventionally generated from human peripheral blood monocytes in the presence of interleukin (IL)-4 and granulocyte/macrophage colony-stimulating factor (GM-CSF). Streptococcal preparation OK-432, which is known to be a multiple cytokine inducer, has been extensively studied as to its maturation effects on immature DCs using an in vitro culture system. The purpose of this study was to examine whether it could be possible to generate mature DCs directly from peripheral monocytes using OK-432. We specifically focused on the possibility that recombinant cytokines, which are considered to be essential for in vitro DC generation, could be substituted by OK-432. Human peripheral monocytes, which were obtained from patients with advanced cancer, were cultured with IL-4 and OK-432 for 7 days. Cultured cells were compared with DCs generated in the presence of IL-4 and GM-CSF with or without OK-432 with regard to the surface phenotype as well as the antigen-presenting capacity. As a result, the culture of monocytes in the presence of IL-4 followed by the addition of OK-432 on day 4 (IL-4/OK-DC) induced cells with a fully mature DC phenotype. Functional assays also demonstrated that IL-4/OK-DCs had a strong antigen-presenting capacity determined by their enhanced antigen-specific CTL response and exerted a Th1-type T cell response which is critical for the induction of anti-tumor response. In conclusion, human peripheral blood monocytes cultured in the presence of IL-4 and OK-432 without exogenous GM-CSF demonstrated a fully mature DC phenotype and strong antigen-presenting capacity. This one-step culture protocol allows us to generate fully mature DCs directly from monocytes in 7 days and thus, this protocol can be applicable for DC-based anti-tumor immunotherapy.

  16. No association between CYP1B1 Val432Leu polymorphism and breast cancer risk: a meta-analysis involving 40,303 subjects. (United States)

    Yao, Lei; Fang, Fang; Wu, Qi; Zhong, Yang; Yu, Long


    Breast cancer is the most common cancer in women. To date, many publications have evaluated the association between Cytochrome P450 1B1 (CYP1B1) Val432Leu polymorphism and breast cancer risk. However, the results remain inconclusive. In order to derive a more precise estimation of the association, a meta-analysis was performed in this study. By searching Medline, Pubmed, and ISI Web of Knowledge databases, 26 studies including 19,028 cases and 21,275 controls were collected for CYP1B1 Val432Leu polymorphism. Crude ORs with 95% CIs were used to assess the strength of association between CYP1B1 Val432Leu polymorphism and breast cancer risk. The pooled ORs were performed for codominant model, dominant model, and recessive model, respectively. Overall, no significant associations between CYP1B1 Val432Leu polymorphism and breast cancer susceptibility were found for Val/Val versus Leu/Leu (OR = 0.98; 95% CI: 0.90-1.06), Val/Leu versus Leu/Leu (OR = 1.01; 95% CI: 0.93-1.09), Val/Val + Val/Leu versus Leu/Leu (OR = 1.00; 95% CI: 0.93-1.08) and Val/Val versus Val/Leu + Leu/Leu (OR = 0.96; 95% CI: 0.91-1.01). In the stratified analysis by ethnicity, menopausal status and sources of controls, significant associations were still not observed in all genetic models. In conclusion, this meta-analysis provides strong evidence that CYP1B1 Val432Leu polymorphism is not associated with breast cancer risk.

  17. Anti-metastasis effect in mouse hepatocellular carcinoma model of vaccination with endothelial cells plus picibanil OK432 as adjuvant%以链球菌制剂OK432为佐剂的内皮细胞疫苗体内抗小鼠肝癌转移的作用

    Institute of Scientific and Technical Information of China (English)

    徐茂磊; 张艳丽; 周玲; 张静; 姚庆收; 杨小平


    目的 评估OK432作为佐剂制备的内皮细胞疫苗体内抗肿瘤转移的作用.方法 以OK432为佐剂,体外混合人脐静脉内皮细胞(HUVEC),制备HUVEC-OK432疫苗.雄性健康BALB/c小鼠尾静脉注射肝癌细胞5×105建立肝癌肺转移模型,皮下注射HUVEC-OK432疫苗,分别在预防性和治疗性免疫中评价HUVEC-OK432疫苗抗肿瘤转移活性;皮内注射5×104肝癌细胞建立皮内肿瘤血管模型,皮下注射HUVEC-OK432疫苗,评价HUVEC-OK432疫苗抑制肿瘤新生血管的活性;采用ELISA的方法测定小鼠免疫血清中HUVEC抗体水平;采用细胞毒T淋巴细胞(CTL)实验考察HUVEC-OK432疫苗诱导的细胞免疫应答水平.结果 肺转移模型结果显示,在预防性和治疗性免疫中,HUVEC-OK432免疫均能有效降低小鼠肺上的肿瘤转移灶数目(P<0.01);皮内肿瘤血管模型的结果显示,HUVEC-OK432免疫能显著降低肿瘤新生血管的数目(116.5±20.6 vs 45.0±8.9,P<0.01);ELISA测定抗体的结果显示,HUVEC-OK432初次免疫后1周小鼠即产生了高滴度的特异性HUVEC抗体,随免疫次数的增加抗体水平不断升高,且该抗体在体外可以显著抑制HUVEC细胞的增殖;CTL实验的结果表明,HUVEC-OK432免疫组淋巴细胞体外有明显的特异性杀伤HUVEC的作用.结论 HUVEC-OK432疫苗免疫可以有效诱导小鼠产生靶向内皮细胞的免疫应答,从而有效抑制小鼠肝癌细胞转移.

  18. A Case of Sublingual Ranula That Responded Successfully to Localized Injection Treatment with OK-432 after Healing from Drug Induced Hypersensitivity Syndrome

    Directory of Open Access Journals (Sweden)

    Kunio Yoshizawa


    Full Text Available A ranula is a mucus retention cyst or pseudocyst caused by leakage of mucus from the sublingual gland and generally occurs in the oral floor. In addition, drug induced hypersensitivity syndrome (DIHS is a rare but well-recognized serious adverse effect characterized by fever, skin rashes, generalized lymphadenopathy, hepatitis, and hepatosplenomegaly and oral stomatitis. This paper presents the first case of successfully treated sublingual ranula with localized injection of OK-432 after healing from drug induced hypersensitivity syndrome, which has previously been unreported in the literature. We present the case of a 38-year-old Japanese woman with sublingual ranula that responded successfully to localized injection treatment with OK-432 after healing from drug induced hypersensitivity syndrome. She was affected with cutaneous myositis and interstitial lung disease when she was 26 years old. At the age 34 years, she received additional oral treatment of diaminodiphenyl-sulfone due to deterioration of the cutaneous myositis, which resulted in drug induced hypersensitivity syndrome (DIHS with severe oral stomatitis. Local injection of OK-432 to the ranula may be a very safe and useful treatment method even if the patient has a history of drug allergy and has connective tissue disease such as cutaneous myositis.

  19. A Case of Sublingual Ranula That Responded Successfully to Localized Injection Treatment with OK-432 after Healing from Drug Induced Hypersensitivity Syndrome (United States)

    Yoshizawa, Kunio; Moroi, Akinori; Kawashiri, Shuichi; Ueki, Koichiro


    A ranula is a mucus retention cyst or pseudocyst caused by leakage of mucus from the sublingual gland and generally occurs in the oral floor. In addition, drug induced hypersensitivity syndrome (DIHS) is a rare but well-recognized serious adverse effect characterized by fever, skin rashes, generalized lymphadenopathy, hepatitis, and hepatosplenomegaly and oral stomatitis. This paper presents the first case of successfully treated sublingual ranula with localized injection of OK-432 after healing from drug induced hypersensitivity syndrome, which has previously been unreported in the literature. We present the case of a 38-year-old Japanese woman with sublingual ranula that responded successfully to localized injection treatment with OK-432 after healing from drug induced hypersensitivity syndrome. She was affected with cutaneous myositis and interstitial lung disease when she was 26 years old. At the age 34 years, she received additional oral treatment of diaminodiphenyl-sulfone due to deterioration of the cutaneous myositis, which resulted in drug induced hypersensitivity syndrome (DIHS) with severe oral stomatitis. Local injection of OK-432 to the ranula may be a very safe and useful treatment method even if the patient has a history of drug allergy and has connective tissue disease such as cutaneous myositis. PMID:27144039

  20. OK-432病变内注射后舌下腺囊肿囊液中IL-1α、TNF-β的变化及意义%The variation and significance of IL-1α、TNF-β in the cyst fluid of ranula before and after OK-432 intralesional injection

    Institute of Scientific and Technical Information of China (English)

    胡砚平; 刘冰; 苏彤; 赵怡芳


    目的 检测OK-432注射前后舌下腺囊肿囊液中IL-1α和TNF-β的含量变化,探讨OK-432治疗的机理.方法 11例舌下腺囊肿患者(单纯型5例,下陷型6例)接受病变内注射OK-432治疗,观察临床疗效,治疗前后抽取囊液分析IL-1α和TNF-β的含量.结果 11例中7例经过一次硬化治疗后囊肿完全消失,2例经过二次治疗后囊肿完全消失,治愈率达82%.患者治疗前后囊液中IL-1α的含量分别为21 pg/ml和765 pg/ml,TNF-β的含量分别为39 pg/ml和1146 pg/ml,有显著性差异.结论 病变内注射OK-432治疗舌下腺囊肿效果好,其机理可能与细胞因子的分泌有关.

  1. 432-μm laser's beam-waist measurement for the polarimeter / interferometer on the EAST Tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Z. X.; Liu, H. Q.; Jie, Y. X. [Chinese Academy of Sciences, Anhui (China); and others


    A far-infrared (FIR) polarimeter / interferometer (PI) system is under development for measurements of the current-density and the electron-density profiles in the EAST tokamak. The system will utilize three identical 432-μm CHCOOH lasers pumped by a CO{sub 2} laser. Measurements of the laser beam's waist size and position are basic works. This paper will introduce three methods with a beam profiler and several focusing optical elements. The beam profiler can be used to show the spatial energy distribution of the laser beam. The active area of the profiler is 12.4 x 12.4 mm{sup 2}. Some focusing optical elements are needed to focus the beam in order for the beam profiler to receive the entire laser beam. Two principles and three methods are used in the measurement. The first and the third methods are based on the same principle, and the second method adopts an other principle. Due to the fast and convenient measurement, although the first method is a special form of the third and it can only give the size of beam waist, it is essential to the development of the experiment and it can provide guidance for the choices of the sizes of the optical elements in the next step. A concave mirror, a high-density polyethylene (HDPE) lens and a polymethylpentene (TPX) lens are each used in the measurement process. The results of these methods are close enough for the design of PI system's optical path.

  2. Association of the CYP1B1 432C/G Gene Polymorphism with Susceptibility to Endometriosis%CYP1B1 432C/G基因多态性与子宫内膜异位症易感性的相关研究

    Institute of Scientific and Technical Information of China (English)

    陈茜; 王玉凤; 宗利丽


    Objective To investigate the association of cytoehrome P450 1B1 in exon 3 codon 432 (C→G) (rs1056836) single nucleotide polymorphism (SNP) with ihe genetic susceptibility to endometriosis (Ems) in south Han Chinese women. Methods A case-control study was performed in 432 Ems patients and 499 control women to evaluate the SNP of CYP1B1 432G/G by using a fluorescent quantitative PCR-based high resolution melting (HRM) method. Results The frequencies of genotypes CC, CG, GG and two alleles CG in controls (77.6%, 21.0% , 1.4% , 88.1% and 11.9%) were not significantly different from those in patients with endometriosis (80.6%, 18.8%, 0.7% , 89.8% and 10.1%). Conclusion There is no significant association between the SNP of CYP1B1 432C/G and genetic susceptibility to Ems in south Han Chinese women.%目的 探讨中国南方汉族妇女CYP1B1基因第3外显子432C/G (rs1056836)位点单核苷酸多态性(single nueleotide polymorphism,SNP)与子宫内膜异位症(endometriosis,Ems)遗传易感性的相关性.方法 收集经手术证实的432例Ems患者和499例对照人群外周血,采用荧光定量PCR为基础的高分辨率熔解曲线分析(high resolution melting,HRM)技术检测CYP1B1 432C/G基因SNP.结果 病例组和对照组妇女CYP1B1 432C/G位点CC、CG、GG基因型频率分别为80.6%、18.8%、0.7%以及77.6%、21.0%、1.4%,2组的基因频率分布差异无统计学意义(P>0.376);C和G等位基因分布为89.8%、10.1%以及88.1%、11.9%,2组差异无统计学意义(P>0.376).结论 中国南方汉族妇女CYP1B1 432C/G位点SNP与Ems遗传易感性无明显相关性.

  3. Association of the CYP1B1 Leu432Val polymorphism with the risk of prostate cancer: a meta-analysis. (United States)

    Cui, Lingling; Dillehay, Kelsey; Chen, Weimin; Shen, Deliang; Dong, Zhongyun; Li, Wenjie


    Cytochrome P450 1B1 (CYP1B1) is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates in endocrine-mediated tumors such as prostate cancer. The potential significance of nonsynonymous SNP Leu432Val (rs1056836) as a risk factor in prostate cancer has been extensively studied. The objective of this meta-analysis was to quantitatively summarize the association between CYP1B1 Leu432Val polymorphism and prostate cancer. All eligible studies were searched and acquired from the PubMed and ISI databases. Statistical analysis was performed by using the software STATA 11.0. Ten case-controlled studies from nine eligible publications were identified, which includes 6,668 subjects with 3,221 cases and 3,447 controls. Overall, no significant association was found between the CYP1B1 Leu432Val polymorphism and prostate cancer susceptibility for Val/Val vs Leu/Leu (OR = 1.07; 95% CI: 0.79-1.44; P = 0.67), Leu/Val vs Leu/Leu (OR = 1.05; 95% CI: 0.94-1.17; P = 0.42), Leu/Val + Val/Val vs Leu/Leu (OR = 1.07; 95% CI: 0.91-1.26; P = 0.40) and Val/Val vs Leu/Val + Leu/Leu (OR = 1.11; 95% CI: 0.86-1.44; P = 0.43). However, a higher risk was found among Asians in all genetic models (Val/Val vs Leu/Leu :OR = 2.48, 95% CI: 1.14-5.39, P = 0.02; Leu/Val vs Leu/Leu: OR = 1.40, 95% CI: 1.03-1.89, P = 0.03; Leu/Val + Val/Val vs Leu/Leu: OR = 1.51, 95% CI = 1.14-2.01, P = 0.004; Val/Val vs Leu/Val + Leu/Leu: OR = 2.50, 95% CI = 1.35-4.56, P = 0.004). We were not able to detect any association in the subgroup analysis by source of controls and genotyping method in all genetic models. In conclusion, this meta-analysis provides evidence that CYP1B1 Leu432Val polymorphism is not associated with prostate cancer risk overall with the exception in Asians.

  4. Ethanol production by a new pentose-fermenting yeast strain, Scheffersomyces stipitis UFMG-IMH 43.2, isolated from the Brazilian forest. (United States)

    Ferreira, Adriana D; Mussatto, Solange I; Cadete, Raquel M; Rosa, Carlos A; Silva, Silvio S


    The ability of a recently isolated Scheffersomyces stipitis strain (UFMG-IMH 43.2) to produce ethanol from xylose was evaluated. For the assays, a hemicellulosic hydrolysate produced by dilute acid hydrolysis of sugarcane bagasse was used as the fermentation medium. Initially, the necessity of adding nutrients (MgSO(4)·7H(2)O, yeast extract and/or urea) to this medium was verified, and the yeast extract supplementation favoured ethanol production by the yeast. Then, in a second stage, assays under different initial xylose and cell concentrations, supplemented or not with yeast extract, were performed. All these three variables showed significant (p UFMG-IMH 43.2 was demonstrated to be a yeast strain with potential for use in xylose conversion to ethanol. The establishment of the best fermentation conditions was also proved to be of great importance to increasing the product formation by this yeast strain. These findings open up new perspectives for the establishment of a feasible technology for ethanol production from hemicellulosic hydrolysates.

  5. Association of genetic polymorphism in CYP1B1 L432V with risk of sporadic endometrial carcinoma%CYP1B1基因L432V多态性与散发子宫内膜癌风险关系的研究

    Institute of Scientific and Technical Information of China (English)

    朱壮彦; 穆雅琴; 富晓敏; 李拴明; 赵富玺


    目的 探讨CYP1B1基因L432V多态性与子宫内膜癌发生危险性的关系.方法 用等位基因特异性PCR(AS-PCR)法,对72例子宫内膜癌患者和80例正常女性的CYP1B1 L432V多态位点进行检测,确定出多态性的3种基因型,即野生型C/C、杂合型C/G、突变型G/G;免疫组化S-P法进一步研究雌激素受体α(Erα)的表达是否受CYP1B1基因多态性的影响.结果 CYP1B1基因L432V多态性C/C、C/G、G/G三种基因型分布频率,子宫内膜患者组分别为47.2%、36.1%和16.7%,对照组分别为68.8%、23.8% 和7.5%;子宫内膜癌患者组C、G等位基因频率为65.3%,34.7%,对照组为80.6%,19.4%.CYP1B1 L432V多态性基因型及等位基因型在两组间分布频率的差异有统计学意义(P<0.05).基因型C/G与C/C比较,G/G与C/C比较OR值分别为2.214(95%CI 1.067~4.593) 倍和3.235(95%CI 1.111~9.425)倍;子宫内膜癌Erα表达检测发现,突变基因型G/G、C/G基因型者Erα阳性表达率高于C/C野生基因型(P<0.05).结论 CYP1B1 L432V多态位点3种基因型的分布与子宫内膜癌发病风险有一定关联,突变基因型增加了子宫内膜癌的发病风险,且与ER的表达相关.

  6. CYP1B1基因Leu432Val位点多态性与头颈癌易感性的Meta分析%Association between CYP1 B1 Leu432Val polymorphism and head and neck cancer risk: a Meta-analysis

    Institute of Scientific and Technical Information of China (English)

    陈睿; 徐晓明; 李娟; 牛玉明; 陈启林


    目的:运用Meta分析方法研究CYP1 B1基因Leu432Val位点多态性与头颈癌易感性的发生风险.方法:检索CNKI和PubMed数据库中有关CYP1 B1基因Leu432Val位点多态性与头颈癌易感性关联研究的文献.对符合纳入标准的文献进行资料提取后,以OR值和95%可信区间为效应指标,应用STATA 11.0软件进行Meta分析,并对发表偏倚进行检测.结果:纳入5个对照研究,共计1580例头颈癌患者和2076例正常对照人群.Meta分析结果显示,总人群中,CYP1 B1基因Leu432Val位点多态性与头颈癌易感性之间有显著关联(Val vs.Leu:OR=1.13,95% CI=1.03-1.25,P=0.014; Val/Val vs.Leu/Leu:OR=1.30,95% CI=1.06-1.60,P =0.013:Val/Val vs.Leu/Leu+ Leu/Val:OR=1.23,95% CI=1.05-1.46,P=0.13).在针对种族的亚组分析中,发现CYP1B1基因Leu432Val位点多态性可能会增加欧洲人群发生头颈癌的风险.结论:CYP1B1基因Leu432Val位点多态性可能是增加欧洲人群发生头颈癌易感性的危险因素.

  7. The Val432Leu polymorphism of the CYP1B1 gene is associated with differences in estrogen metabolism and bone density. (United States)

    Napoli, Nicola; Rini, Giovam Battista; Serber, Daniel; Giri, Tusar; Yarramaneni, Jayasree; Bucchieri, Salvatore; Camarda, Lawrence; Di Fede, Gaetana; Camarda, Marcello Rosolino; Jain, Sudahansu; Mumm, Steven; Armamento-Villareal, Reina


    Polymorphisms of the CYP450 genes that encode for the enzymes that metabolize estrogen are linked to hormone-related cancers. We investigated the impact of two polymorphisms of the CYP1B1 gene previously reported to be associated with hormone-related disorders on estrogen metabolism and bone mineral density (BMD), another hormone-dependent condition, in women from different ethnic backgrounds. Four hundred sixty-eight postmenopausal Caucasian women, 220 from St. Louis, MO, USA (mean age=63.5+/-0.53 years) and 248 from Palermo, Italy (mean age=72.9+/-0.44 years) participated in the study. Measurements of urinary estrogen metabolites by enzyme-linked immunoassay, serum estradiol by ultrasensitive radioimmnunoassay, and serum sex hormone-binding globulin by immunoradiometric assay were performed only in the American women, while BMD by dual energy X-ray absorptiometry and genotyping by pyrosequencing were performed in both American and Italian women. Differences in the levels of metabolites, free estradiol index and BMD were analyzed by analysis of covariance. Analysis among the American participants for the Valine432Leucine polymorphism showed that, compared to women with the Val/Val genotype, women with the Leu allele (Val/Leu and Leu/Leu) had significantly higher log-transformed values of total urinary estrogen metabolite (ng/mg-creatinine) levels (1.23+/-0.04, 1.35+/-0.02, and 1.34+/-0.03; p=0.03), and significantly lower BMD (gm/cm(2)) in the lumbar spine (1.009+/-0.02, 0.955+/-0.01 and 0.931+/-0.02; p=0.03) and the femoral neck (0.748+/-0.02, 0.717+/-0.01 and 0.693+/-001, p=0.03) for the Val/Val, Val/Leu and Leu/Leu genotypes respectively. There were no significant differences in the urinary metabolites and BMD in the different genotypes for the Alanine119Serine polymorphism among the American women. Meanwhile, a separate analysis among the Italian women revealed no significant differences in BMD among the different genotypes for the two polymorphisms

  8. 2011年桂林市432名噪声作业人员健康体检资料分析

    Institute of Scientific and Technical Information of China (English)



    目的 了解噪声作业工人听力损失情况,分析生产性噪声对听力的影响.方法 对2011年桂林市432名噪声作业工人健康体检资料进行分析.结果 检测432人,听力损失的163人,检出率为37.73%.听力损失检出率,18~24岁为28.36%,25~34岁为33.76%,35~44岁为41.87%,45~岁以上为57.41%(P<0.01);接触噪声工龄1~5年的为25.28%,6~10年的为34.21%,11~15年的为50.54%,16~年以上的为68.09%(P<0.01);使用防护用品的为29.11%,未使用的为72.94%(P<0.01).检测432名接触噪声作业工人的864只耳,3 000 Hz听力损失的占7.64%,4 000 Hz听力损失的占10.19%,6 000 Hz听力损失的占7.87%,语音损失的占3.24%.各部分听力损伤者所占比例均有随着接触噪声工龄的增高而而升高的趋势(P<0.01).结论 桂林市噪声作业工人听力损失检出率较高,工龄长、年龄大的听力损失程度严重.

  9. Clinical response, drug survival and predictors thereof in 432 patients with ankylosing spondylitis switching anti tumor necrosis factor α therapy: Results from the Danish nationwide Danbio registry

    DEFF Research Database (Denmark)

    Glintborg, Bente; Østergaard, Mikkel; Krogh, N.


    OBJECTIVE: To investigate frequencies and reasons for switching, treatment responses and drug survival in patients with ankylosing spondylitis (AS) switching tumour-necrosis-factor-α inhibitor (TNFi) treatment in routine clinical care. METHODS: AS patients were identified in the Danish nationwide......, 432 patients (30%) switched to a second and 137 (10%) to a third biological drug. Compared with non-switchers, switchers were more frequently women (33%/22%), had shorter disease duration (3 years/5 years) and higher BASDAI (62(52-76) mm/56(43-69) mm (median(interquartile-range))), Bath AS Functional...... Index (BASFI) (54(39-71) mm/47(31-65) mm) and visual-analogue-scale (VAS) global, pain and fatigue scores when they started the first TNFi (all p...

  10. Vaccination with NY-ESO-1 overlapping peptides mixed with Picibanil OK-432 and montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen. (United States)

    Wada, Hisashi; Isobe, Midori; Kakimi, Kazuhiro; Mizote, Yu; Eikawa, Shingo; Sato, Eiichi; Takigawa, Nagio; Kiura, Katsuyuki; Tsuji, Kazuhide; Iwatsuki, Keiji; Yamasaki, Makoto; Miyata, Hiroshi; Matsushita, Hirokazu; Udono, Heiichiro; Seto, Yasuyuki; Yamada, Kazuhiro; Nishikawa, Hiroyoshi; Pan, Linda; Venhaus, Ralph; Oka, Mikio; Doki, Yuichiro; Nakayama, Eiichi


    We conducted a clinical trial of an NY-ESO-1 cancer vaccine using 4 synthetic overlapping long peptides (OLP; peptides #1, 79-108; #2, 100-129; #3, 121-150; and #4, 142-173) that include a highly immunogenic region of the NY-ESO-1 molecule. Nine patients were immunized with 0.25 mg each of three 30-mer and a 32-mer long NY-ESO-1 OLP mixed with 0.2 KE Picibanil OK-432 and 1.25 mL Montanide ISA-51. The primary endpoints of this study were safety and NY-ESO-1 immune responses. Five to 18 injections of the NY-ESO-1 OLP vaccine were well tolerated. Vaccine-related adverse events observed were fever and injection site reaction (grade 1 and 2). Two patients showed stable disease after vaccination. An NY-ESO-1-specific humoral immune response was observed in all patients and an antibody against peptide #3 (121-150) was detected firstly and strongly after vaccination. NY-ESO-1 CD4 and CD8 T-cell responses were elicited in these patients and their epitopes were identified. Using a multifunctional cytokine assay, the number of single or double cytokine-producing cells was increased in NY-ESO-1-specific CD4 and CD8 T cells after vaccination. Multiple cytokine-producing cells were observed in PD-1 (-) and PD-1 (+) CD4 T cells. In conclusion, our study indicated that the NY-ESO-1 OLP vaccine mixed with Picibanil OK-432 and Montanide ISA-51 was well tolerated and elicited NY-ESO-1-specific humoral and CD4 and CD8 T-cell responses in immunized patients.

  11. CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism. (United States)

    Helmig, Simone; Wenzel, Sibylle; Maxeiner, Hagen; Schneider, Joachim


    Benzo(a)pyrene (BaP), a primary component of tobacco smoke, is activated by cytochrome P450 1B1 (CYP1B1). Smokers homozygous for the C-allele (*1/*1) at the CYP1B1 Leu432Val polymorphism have shown increased CYP1B1 expression, compared to smokers homozygous for the G-allele *3/*3. Since no difference has been shown in CYP1B1 expression between both genotypes in non-smokers, we assumed that the genetic impact is produced in combination with an exogenous induction (e.g. BaP). To confirm this theory and to quantify the effect, we induced human leucocytes with increasing BaP concentrations and determined CYP1B1 mRNA expression with real-time polymerase chain reaction (PCR). We incubated human leucocytes from 27 healthy donors with BaP concentrations ranging from 2.5 to 250 µM. We identified the CYP1B1 genotypes by melting curve analysis and assessed relative CYP1B1 mRNA expression using real-time PCR. Expression was related to β-2-microglobulin with the 2(-ΔΔCT) method. Inducibility of CYP1B1 mRNA by BaP was higher in leucocytes carrying the CYP1B1*1/*1 genotype than in leucocytes carrying the CYP1B1*3/*3 genotype (P = 0.012). We revealed significant differences, with BaP concentrations of 2.5 µM (P = 0.0094), 5 µM (P = 0.027), 10 µM (P = 0.0006), 25 µM (P = 0.0007) and 50 µM (P = 0.017). Homozygous carriers of the C-allele (*1/*1) at the CYP1B1 Leu432Val polymorphism show a higher response to environmental factors, such as carcinogenic BaP, than homozygous carriers of the G-allele *3/*3.

  12. Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432. (United States)

    Aoki, Masatoshi; Ueda, Shugo; Nishikawa, Hiroyoshi; Kitano, Shigehisa; Hirayama, Michiko; Ikeda, Hiroaki; Toyoda, Hideki; Tanaka, Kyosuke; Kanai, Michiyuki; Takabayashi, Arimichi; Imai, Hiroshi; Shiraishi, Taizo; Sato, Eiichi; Wada, Hisashi; Nakayama, Eiichi; Takei, Yoshiyuki; Katayama, Naoyuki; Shiku, Hiroshi; Kageyama, Shinichi


    Combination vaccines of the NY-ESO-1 protein complexed with cholesteryl pullulan (CHP), CHP-NY-ESO-1, and the truncated 146HER2 protein with CHP, CHP-HER2, were subcutaneously administered with the immuno-adjuvant OK-432 to eight esophageal cancer patients. Vaccination was well-tolerated. NY-ESO-1- and HER2-specific antibody responses were analyzed using the patients' sera and samples from previous single CHP-NY-ESO-1 or CHP-HER2 vaccine trial. The responses to NY-ESO-1 in the combination vaccine study were comparable to the single vaccine. For responses to HER2, there were fewer antibody responses in the combination vaccines. Although there were marked individual variations in the antibody responses to the NY-ESO-1 and HER2 antigens, the reaction patterns to these antigens were comparable within each patient. Antibodies to OK-432 were not augmented. Protein cancer vaccines targeting multiple antigens are feasible.

  13. Evidence of a broad structure at an invariant mass of 4.32 GeV/c2 in the reaction e+e- --> pi+pi-psi(2S) measured at BABAR. (United States)

    Aubert, B; Barate, R; Bona, M; Boutigny, D; Couderc, F; Karyotakis, Y; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Grauges, E; Palano, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; del Amo Sanchez, P; Barrett, M; Ford, K E; Harrison, T J; Hart, A J; Hawkes, C M; Morgan, S E; Watson, A T; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schroeder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Cuhadar-Donszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Sherwood, D J; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Best, D S; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Mommsen, R K; Roethel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dvoretskii, A; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Petzold, A; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Grenier, P; Latour, E; Thiebaux, Ch; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Nash, J A; Nikolich, M B; Panduro Vazquez, W; Behera, P K; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F; Lepeltier, V; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Cowan, G; Flaecher, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Staengle, H; Cowan, R; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; McLachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, G; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Rahimi, A M; Ter-Antonyan, R; Wong, Q K; Blount, N L; Brau, J; Frey, R; Igonkina, O; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Chauveau, J; Briand, H; David, P; Del Buono, L; de la Vaissière, Ch; Hamon, O; Hartfiel, B L; John, M J J; Leruste, Ph; Malclès, J; Ocariz, J; Roos, L; Therin, G; Gladney, L; Panetta, J; Biasini, M; Covarelli, R; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Rizzo, G; Walsh, J J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai Tehrani, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; De Groot, N; Franek, B; Olaiya, E O; Wilson, F F; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Legendre, M; Vasseur, G; Yèche, Ch; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Halyo, V; Hast, C; Hryn'ova, T; Innes, W R; Kelsey, M H; Kim, P; Leith, D W G S; Li, S; Luitz, S; Luth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Muller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Va'vra, J; van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Lanceri, L; Vitale, L; Azzolini, V; Martinez-Vidal, F; Banerjee, Sw; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Pappagallo, M; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Flood, K T; Hollar, J J; Kutter, P E; Mellado, B; Mihalyi, A; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Yu, Z; Neal, H


    We present a measurement of the cross section of the process e(+)e(-)-->pi(+)pi(-)psi(2S) from threshold up to 8 GeV center-of-mass energy using events containing initial-state radiation, produced at the SLAC PEP-II e(+)e(-) storage rings. The study is based on 298 fb(-1) of data recorded with the BABAR detector. A structure is observed in the cross section not far above threshold, near 4.32 GeV. We also investigate the compatibility of this structure with the Y(4260) previously reported by this experiment.

  14. Influence of the Cyp1B1 L432V gene polymorphism and exposure to tobacco smoke on Cyp1B1 mRNA expression in human leukocytes. (United States)

    Helmig, Simone; Hadzaad, Bahar; Döhrel, Juliane; Schneider, Joachim


    Cytochrome P450 1B1 (CYP1B1), a phase I enzyme, is involved in the activation of a broad spectrum of procarcinogens. An association of the Cyp1B1 L432V polymorphism with diverse types of cancer, as well as an impact on the catalytic activity of the enzyme, has been described. To show the functional impact of the allelic variant Cyp1B1*3, we investigated the quantitative Cyp1B1 mRNA expression in a population of smokers, nonsmokers, and ex-smokers and determined their genotypes. Detection of the L432V polymorphism in exon 3 of the Cyp1B1 gene was performed by rapid capillary polymerase chain reaction (PCR) with melting curve analysis. For quantitative comparison of Cyp1B1 mRNA levels, real-time PCR was performed using SYBR Green fluorescence in a LightCycler system. Calculations of expression were made with the 2(-DeltaDeltaCT) method. In comparing relative Cyp1B1 mRNA expression, highly significant differences between the two homozygote genotypes *1/*1 and *3/*3 (0.185 +/- 0.027, n = 118 versus 0.071 +/- 0.013, n = 56; p = 0.000), as well as between the heterozygote genotype *1/*3 and the homozygote genotype *3/*3 (0.178 +/- 0.025, n = 171 versus 0.071 +/- 0.013, n = 56; p = 0.000), were revealed. Significant differences between the genotypes were also detected within the subgroups of smokers, nonsmokers, and ex-smokers. No significant differences were determined in comparing the relative Cyp1B1 mRNA expression with regard to tobacco smoke exposure. Our results suggest that genotypes carrying the C allele (*1/*1 and *1/*3) at Cyp1B1 L432V polymorphism have a significantly higher Cyp1B1 mRNA expression compared with the genotype without the C allele (*3/*3). Gene expression of Cyp1B1 mRNA cannot be used as a biomarker for exposure of tobacco smoke.

  15. Identification of proteases produced by entomopathogenic fungi Beauveria bassiana (Bals Vuill. strain CG432 previously activated in coffee berry borer alive (Hypothenemus hampeiIdentificação de proteases produzidas pelo fungo entomopatogênico Beauveria bassiana (Bals Vuill. Cepa CG432 previamente ativada em insetos vivos de broca do café ((Hypothenemus hampei

    Directory of Open Access Journals (Sweden)

    Luiz Filipe Protásio Pereira


    Full Text Available Conídios de fungos entomopatogênicos atravessam o exoesqueleto do inseto pela ação mecânica do tubo germinativo e produção de múltiplas isoformas de proteases, quitinases e lipases em resposta à composição da cutícula do inseto. Desta forma o objetivo deste trabalho foi extrair, purificar e caracterizar a estrutura de proteases produzidas em cultivo submerso por Beauveria bassiana CG432 previamente ativada em adultos vivos de broca-do-café (Hypothenemus hampei. Uma suspensão contendo 106 conídios ativados/mL foi inoculada em meio de cultura líquido a 28ºC, 150 rpm por 3 dias. O extrato de proteases (EP foi obtido da centrifugação a 8000 g por 20 minutos, fracionado e concentrado por ultrafiltração em membrana de porosidade controlada 100 kDa e 3 kDa, respectivamente. A cromatografia de gel filtração em Sephadex G-100 separou um pico proteico (Pico II que apresentou 56% de resíduos do aminoácido ácido aspártico quando analisado por HPLC em coluna de fase reversa ODS-C18; atividade específica 43 vezes superior ao EP sobre soro albumina bovina; atividade de protease tipo-subtilisina e uma única banda proteica revelada por nitrato de prata e Coomassie Brilhant Blue em zimograma sobre gelatina por eletroforese PAGE em condições nativas. A homogeneidade do Pico II foi confirmada pela revelação de uma única banda durante a determinação do pH isoelétrico igual a 4,5, porém a determinação da massa molecular separou 2 bandas de 23 e 26 kDa por eletroforese PAGE-2D. As proteases foram caracterizadas como serino proteases com resíduo cisteína importante para a atividade, pois foram inibidas por fluoreto fenil-metil-sufonil e ácido p-cloromercúriobenzóico. As proteases do Pico II apresentaram Km 4x10-4 sobre substrato tipo-subtilisina.

  16. Observation of a Broad Structure at an Invariant Mass of 4.32 GeV/$c^2$ in the Reaction $e^+e^-\\to\\pi^+\\pi^-\\psi(2S)$ Measured at BaBar

    CERN Document Server

    Aubert, B; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, R; Allen, M T; Allison, J; Allmendinger, T; Altenburg, D D; Andreotti, M; Angelini, C; Anulli, F; Arnaud, N; Aston, D; Azzolini, V; Baak, M; Back, J J; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Barate, R; Bard, D J; Barlow, N R; Barlow, R J; Barrett, M; Bartoldus, R; Batignani, G; Battaglia, M; Bauer, J M; Bechtle, P; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Benelli, G; Berger, N; Bernard, D; Berryhill, J W; Best, D S; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bhuyan, B; Bianchi, F; Biasini, M; Biesiada, J; Blanc, F; Blaylock, G; Blinov, V E; Bloom, P C; Blount, N L; Bomben, M; Bondioli, M; Bonneaud, G R; Bosisio, L; Boutigny, D; Bowerman, D A; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, J E; Briand, H; Brown, C M; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Bugg, W; Bukin, A D; Bula, R; Burchat, P R; Burke, J P; Button-Shafer, J; Buzzo, A; Bóna, M; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Capra, R; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Cenci, R; Chai, X; Chaisanguanthum, K S; Chao, M; Charles, E; Charles, M J; Chauveau, J; Chavez, C A; Chen, A; Chen, C; Chen, E; Chen, J C; Chen, S; Chen, X; Chen, X R; Cheng, B; Cheng, C H; Chia, Y M; Cibinetto, G; Clark, P J; Claus, R; Cochran, J; Coleman, J P; Contri, R; Convery, M R; Cossutti, F; Cottingham, W N; Couderc, F; Covarelli, R; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L; Cristinziani, M; Cunha, A; Curry, S; Côté, D; D'Orazio, A; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, C L; De Nardo, Gallieno; De Sangro, R; De, N; Del Amo-Sánchez, P; Del Buono, L; Del Re, D; Della Ricca, G; Denig, A G; Di Lodovico, F; Di Marco, E; Dingfelder, J C; Dittongo, S; Dong, L; Dorfan, J; Druzhinin, V P; Dubitzky, R S; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Ebert, M; Eckhart, E A; Eckmann, R; Edgar, C L; Edwards, A J; Egede, U; Eigen, G; Eisner, A M; Elmer, P; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Eyges, V; Fabozzi, F; Faccini, R; Fang, F; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flacco, C J; Flack, R L; Flächer, H U; Flood, K T; Ford, K E; Ford, W T; Forster, I J; Forti, F; Fortin, D; Foulkes, S D; Franek, B; Frey, R; Fritsch, M; Fry, J R; Fulsom, B G; Gabathuler, E; Gaidot, A; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gary, J W; Gaspero, M; Gatto, C; Gaz, A; George, K A; Gill, M S; Giorgi, M A; Gladney, L; Glanzman, T; Godang, R; Golubev, V B; Gowdy, S J; Gradl, W; Graham, M T; Graugès-Pous, E; Grenier, P; Gritsan, A V; Groot; Grosdidier, G; Groysman, Y; Hadavand, H K; Haire, M; Halyo, V; Hamano, K; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, A J; Hartfiel, B L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hill, E J; Hirschauer, J F; Hitlin, D G; Hollar, J J; Hong, T M; Honscheid, K; Hopkins, D A; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Hutchcroft, D E; Höcker, A; Igonkina, O; Innes, W R; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jain, V; Jasper, H; Jawahery, A; Jessop, C P; John, M J J; Judd, D; Kadyk, J A; Kagan, H; Karyotakis, Yu; Kass, R; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Klose, V; Knecht, N S; Koch, H; Kolomensky, Yu G; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kreisel, A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; Kyberd, P; La Vaissière, C de; Lacker, H M; Lae, C K; Lafferty, G D; Lanceri, L; Lange, D J; Lankford, A J; Latham, T E; Latour, E; Lau, Y P; Lazzaro, A; Le Diberder, F R; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, S; Li, X; Lista, L; Liu, H; Lo Vetere, M; LoSecco, J M; Lockman, W S; Lombardo, V; Long, O; Lou, X C; Lu, M; Luitz, S; Lund, P; Luppi, E; Lusiani, A; Lutz, A M; Lynch, G; Lynch, H L; Lü, C; Lüth, V; MacFarlane, D B; Macri, M M; Mader, W F; Majewski, S A; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Marchiori, G; Margoni, M; Marks, J; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Mclachlin, S E; Meadows, B T; Mellado, B; Menges, W; Messner, R; Meyer, N T; Meyer, W T; Mihályi, A; Mir, L M; Mishra, K; Mohanty, G B; Mommsen, R K; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morgan, S E; Morganti, M; Morganti, S; Morii, M; Muheim, F; Müller, D R; Nagel, M; Naisbit, M T; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nesom, G; Nicholson, H; Nikolich, M B; Nogowski, R; Nugent, I M; O'Grady, C P; Ocariz, J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Oyanguren, A; Ozcan, V E; Paar, H P; Pacetti, S; Palano, A; Palombo, F; Pan, B; Pan, Y; Panduro-Vazquez, W; Panetta, J; Paolucci, P; Pappagallo, M; Park, W; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, I M; Peters, K; Petersen, B A; Petrella, A; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Piredda, G; Playfer, S; Poireau, V; Polci, F; Pompili, A; Porter, F C; Posocco, M; Prell, S; Prencipe, E; Prepost, R; Pripstein, M; Pruvot, S; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rahmat, R; Rama, M; Ratcliff, B N; Raven, G; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roat, C; Roberts, D A; Robertson, A I; Robertson, S H; Robutti, E; Rodier, S; Roe, N A; Ronan, M T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Roudeau, P; Rubin, A E; Ruddick, W O; Ryd, A; Röthel, W; Sacco, R; Saeed, M A; Safai-Tehrani, F; Saleem, M; Salnikov, A A; Salvatore, F; Samuel, A; Sanders, D A; Santroni, A; Saremi, S; Satpathy, A; Schalk, T; Schenk, S; Schilling, C J; Schindler, R H; Schofield, K C; Schott, G; Schröder, T; Schröder, H; Schubert, J; Schubert, K R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Sharma, V; Shen, B C; Sherwood, D J; Simard, M; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Y I; Smith, A J S; Smith, J G; Snoek, H L; Snyder, A; Sobie, R J; Soffer, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spitznagel, M; Spradlin, P; Steinke, M; Stelzer, J; Stocchi, A; Stoker, D P; Stroili, R; Strom, D; Strube, J; Stugu, B; Stängle, H; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; Suzuki, K; Swain, S K; Taras, P; Taylor, F; Telnov, A V; Teodorescu, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thompson, J M; Tisserand, V; Todyshev, Y K; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Ulmer, K A; Uwer, U; Van Bakel, N; Vasseur, G; Vavra, J; Verderi, M; Viaud, F B; Vitale, L; Voci, C; Voena, C; Volk, A; Wagner, S R; Wagoner, D E; Waldi, R; Walker, D; Walsh, J J; Wang, K; Wang, P; Wang, W F; Wappler, F R; Watson, A T; Weaver, M; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Wilson, F F; Wilson, J R; Wilson, M G; Wilson, R J; Winklmeier, F; Wisniewski, W J; Wittgen, M; Wong, Q K; Wormser, G; Wren, A C; Wright, D H; Wright, D M; Wu, J; Wu, S L; Xie, Y; Yamamoto, R K; Yarritu, A K; Ye, S; Yi, J I; Yi, K; Young, C C; Yu, Z; Yéche, C; Zain, S B; Zallo, A; Zeng, Q; Zghiche, A; Zhang, J; Zhang, L; Zhao, H W; Zhu, Y S; Ziegler, V; Zito, M; Çuhadar-Dönszelmann, T; al, et


    We measure the cross section for the process $e^+e^-\\to\\pi^+\\pi^-\\psi(2S)$ from threshold up to 8 GeV center-of-mass energy using events containing initial-state radiation, produced at the PEP-II $e^+e^-$ storage rings. The study is based on 298 fb$^{-1}$ of data recorded with the BaBar detector. A structure is observed in the cross-section not far above threshold, near 4.32 GeV. This structure is not compatible with the Y(4260) previously reported by this experiment. A single resonance is adequate to describe the cross-section in the low-energy region ($<$5.7 GeV).

  17. Radiofrequency Ablation of Liver Tumors in Combination with Local OK-432 Injection Prolongs Survival and Suppresses Distant Tumor Growth in the Rabbit Model with Intra- and Extrahepatic VX2 Tumors

    Energy Technology Data Exchange (ETDEWEB)

    Kageyama, Ken, E-mail:; Yamamoto, Akira, E-mail:; Okuma, Tomohisa, E-mail:; Hamamoto, Shinichi, E-mail:; Takeshita, Toru, E-mail:; Sakai, Yukimasa, E-mail:; Nishida, Norifumi, E-mail:; Matsuoka, Toshiyuki, E-mail:; Miki, Yukio, E-mail: [Osaka City University, Department of Radiology, Graduate School of Medicine (Japan)


    Purpose: To evaluate survival and distant tumor growth after radiofrequency ablation (RFA) and local OK-432 injection at a single tumor site in a rabbit model with intra- and extrahepatic VX2 tumors and to examine the effect of this combination therapy, which we termed immuno-radiofrequency ablation (immunoRFA), on systemic antitumor immunity in a rechallenge test. Methods: Our institutional animal care committee approved all experiments. VX2 tumors were implanted to three sites: two in the liver and one in the left ear. Rabbits were randomized into four groups of seven to receive control, RFA alone, OK-432 alone, and immunoRFA treatments at a single liver tumor at 1 week after implantation. Untreated liver and ear tumor volumes were measured after the treatment. As the rechallenge test, tumors were reimplanted into the right ear of rabbits, which survived the 35 weeks and were followed up without additional treatment. Statistical significance was examined by log-rank test for survival and Student's t test for tumor volume. Results: Survival was significantly prolonged in the immunoRFA group compared to the other three groups (P < 0.05). Untreated liver and ear tumor sizes became significantly smaller after immunoRFA compared to controls (P < 0.05). In the rechallenge test, the reimplanted tumors regressed without further therapy compared to the ear tumors of the control group (P < 0.05). Conclusion: ImmunoRFA led to improved survival and suppression of distant untreated tumor growth. Decreases in size of the distant untreated tumors and reimplanted tumors suggested that systemic antitumor immunity was enhanced by immunoRFA.

  18. A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen. (United States)

    Kakimi, Kazuhiro; Isobe, Midori; Uenaka, Akiko; Wada, Hisashi; Sato, Eiichi; Doki, Yuichiro; Nakajima, Jun; Seto, Yasuyuki; Yamatsuji, Tomoki; Naomoto, Yoshio; Shiraishi, Kenshiro; Takigawa, Nagio; Kiura, Katsuyuki; Tsuji, Kazuhide; Iwatsuki, Keiji; Oka, Mikio; Pan, Linda; Hoffman, Eric W; Old, Lloyd J; Nakayama, Eiichi


    We conducted a phase I clinical trial of a cancer vaccine using a 20-mer NY-ESO-1f peptide (NY-ESO-1 91-110) that includes multiple epitopes recognized by antibodies, and CD4 and CD8 T cells. Ten patients were immunized with 600 μg of NY-ESO-1f peptide mixed with 0.2 KE Picibanil OK-432 and 1.25 ml Montanide ISA-51. Primary end points of the study were safety and immune response. Subcutaneous injection of the NY-ESO-1f peptide vaccine was well tolerated. Vaccine-related adverse events observed were fever (Grade 1), injection-site reaction (Grade 1 or 2) and induration (Grade 2). Vaccination with the NY-ESO-1f peptide resulted in an increase or induction of NY-ESO-1 antibody responses in nine of ten patients. The sera reacted with recombinant NY-ESO-1 whole protein as well as the NY-ESO-1f peptide. An increase in CD4 and CD8 T cell responses was observed in nine of ten patients. Vaccine-induced CD4 and CD8 T cells responded to NY-ESO-1 91-108 in all patients with various HLA types with a less frequent response to neighboring peptides. The findings indicate that the 20-mer NY-ESO-1f peptide includes multiple epitopes recognized by CD4 and CD8 T cells with distinct specificity. Of ten patients, two with lung cancer and one with esophageal cancer showed stable disease. Our study shows that the NY-ESO-1f peptide vaccine was well tolerated and elicited humoral, CD4 and CD8 T cell responses in immunized patients.

  19. CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms and bladder cancer risk in a Turkish population. (United States)

    Berber, Ufuk; Yilmaz, Ismail; Yilmaz, Omer; Haholu, Aptullah; Kucukodaci, Zafer; Ates, Ferhat; Demirel, Dilaver


    We aimed to investigate bladder cancer risk with reference to polymorphic variants of cytochrome p450 (CYP) 1A1, CYP1B1, glutathione S-transferase (GST) M1, and GSTT1 genes in a case control study. Polymorphisms were examined in 114 bladder cancer patients and 114 age and sex-matched cancer-free subjects. Genotypes were determined using allele specific PCR for CYP1A1 and CYP1B1 genes, and by multiplex PCR and melting curve analysis for GSTM1 and GSTT1 genes. Our results revealed a statistically significant increased bladder cancer risk for GSTT1 null genotype carriers with an odds ratio of 3.06 (95% confidence interval=1.39-6.74, p=0.006). Differences of CYP1A1, CYP1B1 and GSTM1 genotype frequencies were not statistically significant between patients and controls. However, the specific combination of GSTM1 null, GSTT1 null, and CYP1B1 codon 119 risk allele carriers and specific combination of GSTM1 present, GSTT1 null, and CYP1B1 432 risk allele carriers exhibited increased cancer risk in the combined analysis. We did not observe any association between different genotype groups and prognostic tumor characteristics of bladder cancer. Our results indicate that inherited absence of GSTT1 gene may be associated with bladder cancer susceptibility, and specific combinations of GSTM1, GSTT1 and CYP1B1 gene polymorphisms may modify bladder cancer risk in the Turkish population, without any association being observed for CYP1A1 gene polymorphism and bladder cancer risk.

  20. 20 CFR 702.432 - Debarment process. (United States)


    ... care provider to remove authorization to render medical care or service under the Longshore and Harbor... WORKERS' COMPENSATION ACT AND RELATED STATUTES ADMINISTRATION AND PROCEDURE Medical Care and Supervision Debarment of Physicians and Other Providers of Medical Services and Suppliers and Claims...

  1. 40 CFR 432.1 - General Applicability. (United States)


    ... waters of the U.S. from facilities engaged in the slaughtering, dressing and packing of meat and poultry... meat scraps. Manufacturing activities which may be subject to this part are generally reported...

  2. QTL Information Table: 432 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available DHL CT9993-5-10-1-M IR62266-42-6-2 B CDO20 pha Nguyen, T.T., Klueva, N., Chamareck, V., Aarti, A., Magpanta...y, G., Millena, A.C., Pathan, M.S., and Nguyen, H.T. (2004). Saturation mapping of QTL regions and identific

  3. 40 CFR 432.2 - General definitions. (United States)


    ...) Fecal coliform means the bacterial count, as determined by approved methods of analysis for Parameter 1..., breaking, trimming, skinning, tenderizing, marinating, curing, pickling, extruding and/or linking. (f) LWK... quarter carcasses or small meat cuts. (l) The approved methods of analysis for the following...

  4. BDML Metadata: 432 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available Ce_AK BDML file for the result of computer simulation of male pronuclear migration C. elegans embryo the result of computer simulation of male pronuclear migration in C. elegans embryo (me

  5. Reference: 432 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available imitsune et al. 2006 Sep. Plant J. 47(5):751-60. In mammals, the electron transfer flavoprotein (ETF) is a h...east nine mitochondrial matrix flavoprotein dehydrogenases. Electrons accepted by ETF are further transfe...tial roles of the ETF/ETFQO electron transfer complex in the catabolism of leucine and involvement in the ch...lorophyll degradation pathway activated during dark-induced carbohydrate deprivation. The mitochondrial electron transfe...tended darkness. 5 751-60 16923016 2006 Sep The Plant journal Fernie Alisdair R|Graham Ian A|Ishizaki Kimitsune|Larson Tony R|Leaver Christopher J|Schauer Nicolas

  6. 5 CFR 432.102 - Coverage. (United States)


    ... accordance with 5 U.S.C. 3321(b); (2) The reduction in grade or removal of an employee in the competitive... grade or removal of an employee in the competitive service serving in an appointment that requires no... corporation; (2) The Central Intelligence Agency; (3) The Defense Intelligence Agency; (4) The...

  7. 42 CFR 432.2 - Definitions. (United States)


    ... duties are an integral part of the agency's responsibility for planning, administration, and for delivery..., unemployment compensation, health insurance, and similar expenses. Full-time training means training that... participate in a training program. Part-time training means training that allows employees to continue...

  8. Triangular oxalate clusters [W(3)(mu(3)-S)(mu(2)-S(2))(3)(C(2)O(4))(3)](2)(-) as building blocks for coordination polymers and nanosized complexes. (United States)

    Sokolov, Maxim N; Gushchin, Artem L; Kovalenko, Konstantin A; Peresypkina, Eugenia V; Virovets, Alexander V; Sanchiz, Joaquin; Fedin, Vladimir P


    The reaction of aqueous [W3S7(C2O4)3](2-) with Ln(3+) and Th(4+) in a 1:1 molar ratio leads to oxalate-bridged heteropolynuclear molecular complexes and coordination polymers. La(3+) and Ce(3+) give a layered structure with big (about 1.8 nm) honeycomb pores which are filled with water molecules and lanthanide ions, in {[Ln(H2O)6]3[W3S7(C2O4)3]4}Br x xH2O (Ia and Ib). The smaller Pr(3+), Nd(3+), Sm(3+), Eu(3+), and Gd(3+) ions give discrete nanomolecules [(W3S7(C2O4)3Ln(H2O)5)2(mu-C2O4)] (with a separation of about 3.2 nm between the most distant parts of the molecule), which are further united into zigzag chains by specific S2...Br- contacts to achieve the overall stoichiometry K[(W3S7(C2O4)3Ln(H2O)5)2(mu-C2O4)]Br.xH2O (IIa-IId). Th(4+) gives K2[(W3S7(C2O4)3)4Th2(OH)2(H2O)10] x 14.33H2O (III) with a nanosized discrete anion (with a separation of about 2.7 nm between the most distant parts of the molecule), in which two thorium atoms are bound via two hydroxide groups into the Th2(OH)2(6+) unit, and each Th is further coordinated by five water molecules and two monodentate [W3S7(C2O4)](2-) cluster ligands. All compounds were characterized by X-ray structure analysis and IR spectroscopy. Magnetic susceptibility measurements in the temperature range of 2-300 K show weak antiferromagnetic interactions between two lanthanides atoms for compounds IIa, IIb, and IId. The thermal decomposition of Ia, Ib, and IIb was studied by thermogravimetry.

  9. A Novel One-dimensional Reduced Molybdenum(Ⅴ) Decorated with Nickel Coordination Cations: Ni[Mo6O12(OH)3(PO4)(HPO4)3]2[Ni(H2O)2][Ni(H2O)(bipy)2]4·5H2O

    Institute of Scientific and Technical Information of China (English)

    GUO Hong-Xu; WANG Qing-Hua; CHEN Chen; LIANG Min; CHEN Ling


    A novel molybdenum(Ⅴ) phosphate decorated with nickel complex cations, Ni[Mo6O12(OH)3(PO4)(HPO4)3]2-[Ni(H2O)2][Ni(H2O)(bipy)2]4·5H2O (bipy=2,2'-bipyridyl), has been hydrothermally synthesized and characterized by IR, TGA and single-crystal X-ray diffraction. Two {Mo6P4} clusters are linked via one Ni cation to form a Ni[Mo6P4]2 dimer unit, which is further connected together by additional nickel coordination complex ions to give 1-D molybdenum(Ⅴ) phosphate chain-like structure. A probe reaction of the oxidation of benzaldehyde with H2O2 using the title compound as catalyst was carried out in a liquid-solid system, showing that the compound had high oxidative catalytic activity to the reaction.

  10. 42 CFR 432.50 - FFP: Staffing and training costs. (United States)


    ...) For skilled professional medical personnel and directly supporting staff of the Medicaid agency or of... medical personnel and directly supporting staff—(1) Medicaid agency personnel and staff. The rate of 75 percent FFP is available for skilled professional medical personnel and directly supporting staff of...

  11. 47 CFR 74.432 - Licensing requirements and procedures. (United States)


    ... stations may operate as automatic relay stations on the frequencies listed in § 74.402(b)(4) and (c)(1... unattended. Prior Commission authority shall be obtained for the installation of any transmitting antenna... at the control point of the station. (k) In case of permanent discontinuance of operations of...

  12. The 4-3-2 method for Kegel exercises. (United States)

    Bridgeman, Bruce; Roberts, Steven G


    Performing Kegel exercises following prostatectomy is helpful in restoring continence, but requires concentration to accomplish the required contractions consistently. Confusion and effort with executing the procedure can reduce compliance. A new method subdivides the exercises into segments that can be executed without counting. The patient performs four sets of contractions daily, each set consisting of three contractions lasting two natural breaths, separated by two natural breaths. Because each number is below the limit that can be apprehended by subitizing without counting, cognitive effort is minimized.

  13. EISA 432 Energy Audits Best Practices: Software Tools

    Energy Technology Data Exchange (ETDEWEB)

    Maryl Fisher


    Five whole building analysis software tools that can aid an energy manager with fulfilling energy audit and commissioning/retro-commissioning requirements were selected for review in this best practices study. A description of each software tool is provided as well as a discussion of the user interface and level of expertise required for each tool, a review of how to use the tool for analyzing energy conservation opportunities, the format and content of reports generated by the tool, and a discussion on the applicability of the tool for commissioning.

  14. Dicty_cDB: SFC432 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ia and immune antigen for suppressing growth of plasmodium. 76 5e-50 9 BD183625 |...BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 76 5e-50

  15. 42 CFR 432.55 - Reporting training and administrative costs. (United States)


    ... agency training activities directly related to the program: Use of space, postage, teaching supplies, and purchase or development of teaching materials and equipment, for example, books and audiovisual aids. (6..., clerical assistance, teaching materials and equipment such as books and audiovisual aids. (c)...

  16. Dicty_cDB: CHE432 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available quence. 64 5e-07 2 CA813481 |CA813481.1 CA48LN10IF-E8 Cabernet Sauvignon Leaf - C...A48LN Vitis vinifera cDNA clone CA48LN10IF-E8 5', mRNA sequence. 64 6e-07 2 CB341828 |CB341828.2 CA32EN0002_IIIbF_E01 Caberne

  17. The INTEL 432/670 and ADA Performance Benchmarks. (United States)


    a QUICK.MSE"); with text4-io,imtio~guicksort; use texto -io,intio,quicksort; package body OUICKSORT is procedure SORT(1eft~ri(3ht : in subimt; arg...time and ’fuss’, A knowledge of ADA is assumed, as is familiarity with VMS (e.g. the VMS editor ), Referring back to Figure(63 it can be seen that a

  18. 40 CFR 432.125 - New source performance standards (NSPS). (United States)


    ... 16 Fecal Coliform (2) (3) O&G (as HEM) 14 8.0 TSS 30 20 1 mg/L (ppm). 2 Maximum of 400 MPN or CFU per... (ppm). 2 Maximum of 400 MPN or CFU per 100 mL at any time. 3 No maximum monthly average limitation....

  19. 40 CFR 432.115 - New source performance standards (NSPS). (United States)


    ... ) O&G (as HEM) 14 8.0 TSS 30 20 1 mg/L (ppm). 2 Maximum of 400 MPN or CFU per 100 mL at any time. 3 No...&G (as HEM) 14 8.0 TSS 30 20 Total Nitrogen 147 103 1 mg/L (ppm). 2 Maximum of 400 MPN or CFU per...

  20. 42 CFR 417.432 - Conversion of enrollment. (United States)


    ...) Expedited submittal of information to CMS. The HMO or CMP must notify CMS, within the following time frames... necessary for CMS to include the enrollee in its records as a Medicare enrollee of the HMO or CMP: (1) At... her 25th month of entitlement to social security disability benefits under title II of the Act...

  1. Dicty_cDB: AFJ432 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 5067-2090751 strain AX4, complete sequence. 36 0.082 11 AY077834 |AY077834.1 Sheep...pox virus strain NISKHI, complete genome. 36 0.12 9 AY077832 |AY077832.1 Sheeppox virus strain TU-V02127, c...omplete genome. 36 0.12 9 AY077833 |AY077833.1 Sheeppox virus strain A, complete genome. 36 0.12 9 AC010669

  2. 9 CFR 93.432 - Cattle from the Republic of Ireland. (United States)


    ... days of the date of export; (i) Plate or Tube agglutination test conducted in dilutions to detect... Plate or Tube agglutination test, negative to the brucellosis card test and negative to the CF test as...) Cattle showing a serological titer more than 60 IU to the Plate or Tube agglutination test, or a...

  3. 42 CFR 412.432 - Method of payment under the inpatient psychiatric facility prospective payment system. (United States)


    ... submittal of bills to the intermediary beyond the normal billing cycle. (2) Approval of accelerated payment...-related costs for each inpatient stay following submission of a bill. (b) Periodic interim payments (PIP... payments are made based on the submission of a discharge bill and represents final payment subject to...

  4. 432 püksipaari Riia kongresside palee fassaadil / Lauri Kärk

    Index Scriptorium Estoniae

    Kärk, Lauri, 1954-


    Filmifestivalil "Arsenals" sai parima režissööri kujukese Mait Laas nukufilmi "Teekond Nirvaanasse" eest, teise koha preemia Valentin Kuigi mängufilm "Lurjus" ja Riho Undi nukufilm "Saamuel internetis". Peaauhinna andis loos shoti naisrežissööri Lynne Ramsay mängufilmile "Rotipüüdja" ("Ratcatcher")

  5. 40 CFR 432.3 - General limitation or standard for pH. (United States)


    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false General limitation or standard for pH... standard for pH. Any discharge subject to BPT, BCT, or NSPS limitations or standards in this part must remain within the pH range of 6 to 9....

  6. 维棉布经纱在S432型祖克浆纱机上的高压上浆%High Pressure Sizing of the Vinylon/Cotton Warp Yarns with S432 Type Sucker Sizing Machine

    Institute of Scientific and Technical Information of China (English)

    陈新祥; 余桂莲



  7. 11 CFR 103.3 - Deposit of receipts and disbursements (2 U.S.C. 432(h)(1)). (United States)


    ... receipts by a political committee shall be deposited in account(s) established pursuant to 11 CFR 103.2... the treasurer memorializing an oral communication explaining why the contribution is legal. If the... on new evidence not available to the political committee at the time of receipt and deposit,...

  8. 40 CFR 432.12 - Effluent limitations attainable by the application of the best practicable control technology... (United States)


    ... provided in 40 CFR 125.30 through 125.32, any existing point source subject to this subpart must achieve... daily 1 Maximum monthly avg. 1 BOD 5 0.24 0.12 Fecal Coliform (2) (3) O&G 4 0.12 0.06 TSS 0.40 0.20 1... Limitations Regulatedparameter Maximum daily 1 Maximum monthly avg. 1 BOD 5 0.04 0.02 TSS 0.08 0.04 1...

  9. 40 CFR 432.42 - Effluent limitations attainable by the application of the best practicable control technology... (United States)


    ... where the ratio of avg. wt. of processed meat products/avg. LWK is 0.55. Adjustments can be made for... the following ratio: lbs processed meat products/lbs LWK. 3 Maximum of 400 MPN or CFU per 100 mL...

  10. Critical Pedagogy, Physical Education and Urban Schooling. Counterpoints: Studies in the Postmodern Theory of Education. Volume 432 (United States)

    Fitzpatrick, Katie


    "Critical Pedagogy, Physical Education and Urban Schooling" is a critical ethnography of health, physical education and the schooling experiences of urban youth. The subjects of health and physical education are compulsory in most schools internationally, but many contemporary practices in these subjects reinforce rather than challenge the…

  11. Type-specific human papillomavirus distribution in invasive cervical carcinomas in Paraguay. A study of 432 cases. (United States)

    Kasamatsu, Elena; Cubilla, Antonio L; Alemany, Laia; Chaux, Alcides; Tous, Sara; Mendoza, Laura; Paez, Malvina; Klaustermeier, Jo Ellen; Quint, Wim; Lloveras, Belen; de Sanjose, Silvia; Muñoz, Nubia; Bosch, Francisco Xavier


    Cervical carcinoma is the most common malignant tumor among woman in Paraguay. Cytological screening programs have not been successful and a plan for human papillomavirus (HPV) based-screening program and/or vaccination is under evaluation. This study aimed to identify the contribution of HPV genotypes in invasive cervical cancer in Paraguay to provide essential background data to guide and assess the introduction and impact of new preventive strategies based on HPV. Four hundred thirty two histologically confirmed cases (1960-2004) were analyzed. HPV detection in paraffin blocks was performed at the Catalan Institute of Oncology using PCR with SPF-10 broad spectrum primers followed by DNA enzyme immunoassay and genotyping with a reverse hybridization line probe analysis. The majority of cases were squamous cell carcinoma (92.8%). Mean patients age was 48 years old. HPV DNA was detected in 73.1% of the cases and single infections were predominant (97.8%). The most common HPV single types were 16, 18, 45, 33, 31, 52, 35, and 39. 73.1% of HPV positive cases had an HPV 16, 18 as single infection. HPV16 was frequent in SCC whereas HPV 18 and 45 were prevalent in glandular tumors. Significant decrease of HPV 16 with age groups (P-trend = 0.022) and increase in other HPV types (P-trend > 0.001) were observed. The potential impact of HPV 16 and 18 for a vaccination program was 73.1%. The study provide a profile of the HPV situation in the country, with robust clinical, pathological and virological data which would permit a better cervical cancer screening and vaccination programs.

  12. SQL Server 2008 Administration Real World Skills for MCITP Certification and Beyond (Exams 70-432 and 40-450)

    CERN Document Server

    Carpenter, Tom


    The ideal on-the-job reference guide for SQL Server 2008 database administrators. If you manage and administer SQL Server 2008 in the real world, you need this detailed guide at your desk. From planning to disaster recovery, this practical book explores tasks and scenarios that a working SQL Server DBA faces regularly and shows you step by step how to handle them. Topics include installation and configuration, creating databases and tables, optimizing the database server, planning for high availability, and more. And, if you're preparing for MCTS or MCITP certification in SQL Server 2008 admin

  13. SU-E-T-432: Field Size Influence On the Electron and Photon Spectra Within Small MV Field Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Benmakhlouf, H; Andreo, P [Department of Medical Physics, Karolinska University Hospital, Stockholm and Department of Physics, Medical Radiation Physics, Stockholm University (Sweden)


    Purpose: To investigate the influence of photon field size on the electron and photon fluence spectra in the active volume of small field detectors. Methods: The PENELOPE MC system based usercode PenEasy was used to calculate the material influence on the spectra by scoring the differential fluence in inserts of silicon, carbon, phosphorus and aluminium having 3 mm diameter and height. The spectra were then calculated inside the active volume of eleven detectors (ion chambers and solid-state detectors) whose geometry was simulated with great detail. The inserts/detectors were placed at 10 cm depth in a 30 cm x 30 cm x 30 cm water phantom and irradiated with 2.5 MeV photons and Varian Clinac 6 MV beams of small, medium and large size. Results: For all configurations, photon spectra in the scoring volume were similar to that in a small water volume except for additional characteristic x-ray peaks resulting from the material itself and from the materials surrounding the detectors (i.e. high-Z shielding the silicon). Electron fluence calculated in the inserts were up to 60% larger than in water; the difference increased with material density and decreasing field size. MC-calculated doses were compared to analytically determined collision kerma and restricted cema (cut-off=15keV). For the inserts, with large and medium fields K-col agreed with MC-dose, but K-col overestimated the dose for small fields due to lack of lateral CPE. For the detectors, up to 15% differences between K-col and the MC-dose were found. For all configurations the C-delta and MC-dose agreed within ±2%. Conclusion: The most relevant findings were that shielding affects substantially the photon spectra and material conditions the electron spectra, their field size dependence varying with the geometry configuration. These affect the values of factors entering into relative dosimetry.

  14. 30 CFR 250.432 - How do I obtain a departure to diverter design and installation requirements? (United States)


    ... to: Then you must... (a) Use flexible hose for diverter lines instead of rigid pipe Use flexible hose that has integral end couplings. (b) Use only one spool outlet for your diverter system (1) Have...

  15. The incidence of apparent congenital urogenital anomalies in North Indian newborns: A study of 20,432 pregnancies

    Directory of Open Access Journals (Sweden)

    A. Bhat


    Conclusions: The incidence of apparent congenital urogenital anomalies was 3.91%. Infertility treatment, parity >2 and a maternal age >30 years were independently associated with an increased risk of congenital urogenital anomalies.

  16. 76 FR 432 - Airworthiness Directives; Airbus Model A330-201, -202, -203, -223, and -243 Airplanes; Airbus... (United States)


    ... October 1, 2010 (75 FR 60655). That NPRM proposed to correct an unsafe condition for the specified...'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have... definition review against explosion hazards. * * * * * Failure of the auxiliary power unit (APU) bleed...

  17. 32 CFR 644.432 - Assignment to Department of Health, Education, and Welfare (HEW) or successor agencies for health... (United States)


    ... the protection of public health, including research. The Secretary of HEW is authorized under section... Office simultaneously with notification to the District Engineer that the property has been determined... a determination of its probable suitability for uses authorized in section 203(k)(1) of the Act....

  18. 18 CFR 4.32 - Acceptance for filing or rejection; information to be made available to the public; requests for... (United States)


    ... study, its methodology and objectives, whether the recommended study methods are generally accepted in... available. In addition, in the case of a study request by a resource agency or Indian tribe that had failed... or rejection; information to be made available to the public; requests for additional studies....

  19. Wind sensitivity studies of a non-return wind tunnel, with a 216- by 432-mm (8.5- by 17.0-inch) test section, phase 1 (United States)

    Eckert, W. T.; Mort, K. W.; Piazza, J. E.


    The study to develop inlet and exit treatments which would minimize the effect of external wind on the test-section flow quality of a nonreturn wind tunnel is reported. The investigation was conducted in the Ames Research Center 40- by 80-Foot Wind Tunnel which served as the wind source. Several inlets and two exits were tested at wind directions ranging from 0 to 180 degrees and at wind-to-test-section velocity ratios between zero and one. For the best inlet configuration the flow quality was good, with a velocity deviation in each of the three directions generally less than 1/2 knot (0.26 m/sec) for wind velocities of 15 knots (7.7 m/sec) or less. The loss in total pressure due to the inlet treatment was low: about 0.03 of the test-section dynamic pressure.

  20. Wind sensitivity studies of a non-return wind tunnel with a 216- by 432-mm (8.5- by 17.0-inches) test section, phase 2 (United States)

    Eckert, W. T.; Mort, K. W.; Piazza, J. E.


    The refinement of inlet and exit treatments were studied which would minimize the effect of external wind on the test-section flow quality of a nonreturn wind tunnel. The investigation was conducted in the Ames Research Center 40- by 80-foot Wind Tunnel which served as the wind source. Several inlets and two exits were tested at wind directions ranging from 0 to 180 degrees and at wind-to-test-section velocity ratios from zero to somewhat greater than one. For the best inlet configuration the flow quality was good, with a velocity deviation in each of the three component directions generally less. The loss in total pressure due to the inlet treatment was low: about 0.035 of the test-section dynamic pressure for the no-wind case.

  1. 75 FR 15419 - Notice of Intent To Grant Exclusive License of U.S. Patent Application No. 12/432,842 Filed April... (United States)


    .... ADDRESSES: United States Army Engineer Research and Development Center, Waterways Experiment Station, Attn...-government inventors. The technology claimed in this patent application improves a soil's resistance to deformation, prevents complete rewetting of the soil which improves freeze-thaw resistance and durability,...

  2. Nuclear Regulatory Commission issuances: Opinions and decisions of the Nuclear Regulatory Commission with selected orders, July 1--December 31, 1996. Volume 44, Pages 1--432

    Energy Technology Data Exchange (ETDEWEB)



    The hardbound edition of the Nuclear Regulatory Commission Issuances is a final compilation of the monthly issuances. It includes all of the legal precedents for the agency within a six-month period. Any opinions, decisions, denials, memoranda and orders of the Commission inadvertently omitted from the monthly softbounds and any corrections submitted by the NRC legal staff to the printed softbound issuances are contained in the hardbound edition. Cross references in the text and indexes are to the NRCI page numbers which are the same as the page numbers in this publication. Issuances are referred to as follows: Commission--CLI, Atomic Safety and Licensing Boards--LBP, Administrative Law Judges--ALJ, Directors` Decisions--DD, and Decisions on Petitions for Rulemaking--DPRM.

  3. Is determination between complete and incomplete traumatic spinal cord injury clinically relevant? Validation of the ASIA sacral sparing criteria in a prospective cohort of 432 patients.

    NARCIS (Netherlands)

    Middendorp, J.J. van; Hosman, A.J.F.; Pouw, M.H.; Meent, H. van de


    STUDY DESIGN: Prospective multicenter longitudinal cohort study. OBJECTIVE: To validate the prognostic value of the acute phase sacral sparing measurements with regard to chronic phase-independent ambulation in patients with traumatic spinal cord injury (SCI). SETTING: European Multicenter Study of

  4. Geographic distribution of 119 alleles of the alpha and beta globin genes detected in 432 French Caucasian carriers of haemoglobin variant. (United States)

    Chami, B; Braconnier, F; Riou, J; Bardakdjian-Michau, J; Préhu, C; Blouquit, Y; Rosa, J; Wajcman, H; Galactéros, F


    The French population is the result of mixing of different peoples including the Celts, Saxons, Germans, Italians and Hispanics. Between 1981 and 1993 patients were selected during investigations in France for haematological disorders associated or otherwise with the presence of a haemoglobin (Hb) variant. Further carriers of abnormal Hb were identified by HPLC measurement of glycated Hb in diabetics and by neonatal screening. Four-hundred and thirty-two subjects were found to be heterozygous for one of the 119 different alpha and the beta gene alleles encountered. These variants were characterised by a combination of 6 electrophoretic methods and in some cases by protein structure determinations. Some mutants reflected the population movements in and into France. A few mutants are frequently described in the French Caucasian population: Hb Lepore Boston, Hb D Punjab, whereas others appear to be anthropological markers. Hb Winnipeg has only been found in the West of France (Normandy); Hb J Baltimore is mainly found in French subjects of Spanish origin. Several cases of sporadic and previously undescribed mutations of Hb were identified. The last immigration waves from Africa and Asia appear to have contributed to the evolution of the pattern of haemoglobinopathies in the French population (Hb S, Hb O Arab or Hb C).

  5. Beliefs, practices and attitudes of portuguese undergraduate youth (Crenças, práticas e atitudes da juventude universitária portuguesa. DOI: 10.5752/P.2175-5841.2012v10n26p432

    Directory of Open Access Journals (Sweden)

    José Pereira Coutinho


    Full Text Available Abstract This paper presents results of the author’s PhD research: Catholic beliefs and practices, attitudes toward marriage, life and sexuality. The empirical support is a survey made to a sample of 500 students from Lisbon public universities, using a non-random sampling in two phases, first a quota sampling and after a convenience one. There are some results that stand out. More than half of students of the sample call themselves Catholic and believe in the dogmatic representations about God, Jesus and Mary, though other dogmatic beliefs as hell, purgatory and resurrection are much lower. There is some spirituality among students, although the importance of God is less important. The frequencies of the Mass, prayer, Holy Communion, confession are all very low. The attitudes toward marriage, life and sexuality lie between ‘some’ and ‘very’, with abortion having the smallest rating and contraception the highest. In general, undergraduate youth is away from the norms of the Church. At the same time, these youngsters believe and belong more than they practice. Keywords: Beliefs. Practices. Attitudes. Portugal. Undergraduate students.   Resumo Este artigo apresenta resultados da tese de doutoramento do autor: crenças e práticas católicas, atitudes em relação ao casamento, à vida e à sexualidade. O suporte empírico é um inquérito aplicado a uma amostra de 500 estudantes das universidades públicas de Lisboa, usando uma amostragem não aleatória em duas fases, primeiro a amostragem por quotas e depois a amostragem por conveniência. Há alguns resultados que se destacam. Mais do que metade da amostra denomina-se católica e acredita nas representações dogmáticas de Deus, Jesus e Maria, embora outras crenças dogmáticas como inferno, purgatório e ressurreição sejam bastante mais baixas. Há alguma espiritualidade entre os estudantes, embora menos considerem que Deus seja importante. A frequência da Missa, oração, comunhão, confissão é muito baixa. As atitudes relativamente ao casamento, vida e sexualidade estão entre ‘alguma’ e ‘muita’, tendo o aborto o valor mais pequeno e a contracepção o valor maior. Na generalidade, a juventude universitária está afastada das normas da Igreja. Ao mesmo tempo, eles acreditam e pertencem mais do que praticam. Palavras-chave: Crenças. Práticas. Atitudes. Portugal. Estudantes niversitários.

  6. Comments on “Hepatic radioembolization with yttrium-90 glass microspheres for treatment of primary liver cancer" by Cao et al, Chin Med J 1999;112:430-432

    Institute of Scientific and Technical Information of China (English)


    @@Editors,   We would like to congratulate Cao and his colleagues on the extremely good mean survival rate of 19.5 months achieved in 17 patients with non-resectable liver cancer (16 primary and 1 metastatic).1 Because the results of their study sounds so promising, centres having access to glass yttrium-90 (90Y) microspheres may want to try their methods. It is therefore necessary to clarify some of the points mentioned in their report.

  7. Teacher's Guide for Computational Models of Animal Behavior: A Computer-Based Curriculum Unit to Accompany the Elementary Science Study Guide "Behavior of Mealworms." Artificial Intelligence Memo No. 432. (United States)

    Abelson, Hal; Goldenberg, Paul

    This experimental curriculum unit suggests how dramatic innovations in classroom content may be achieved through use of computers. The computational perspective is viewed as one which can enrich and transform traditional curricula, act as a focus for integrating insights from diverse disciplines, and enable learning to become more active and…

  8. Prostate cancer risk and aggressiveness associated with the CYP1B1 4326C/G (Leu432Val) polymorphism: a meta-analysis of 2788 cases and 2968 controls. (United States)

    Yang, Jie; Xu, Dong-Liang; Lu, Qiang; Han, Zhi-Jian; Tao, Jun; Lu, Pei; Wang, Chao; Di, Xiao-Ke; Gu, Min


    To derive a precise estimation of the associations between the cytochrome P450 1B1 (CYP1B1) 4326C/G variants and prostate cancer (PCa) risk or aggressiveness, a meta-analysis was performed using all eligible published studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association in seven literature studies with 2788 cases and 2968 controls. In the overall analysis, no significant association was found between the CYP1B1 4326C/G polymorphism and PCa risk, but ethnicity subgroup analyses and a case-source analysis revealed significant associations. The 4326G allele showed a significant association with increased PCa risk in Asians (OR=1.52, 95% CI: 1.20-1.92), and significant associations were also observed in a heterozygote comparison (OR=1.40, 95% CI: 1.03-1.89), a homozygote comparison (OR=2.38, 95% CI: 1.31-4.33) and in a dominant genetic model (OR=1.52, 95% CI: 1.14-2.01). Moreover, the 4326G allele was also significantly correlated with an increased risk of sporadic PCa (OR=1.13, 95% CI: 1.04-1.24), and significant associations were observed in a heterozygote comparison (OR=1.16, 95% CI: 1.02-1.33), a homozygote comparison (OR=1.24, 95% CI: 1.03-1.49) and a dominant genetic model (OR=1.19, 95% CI: 1.05-1.34). The overall analyses and all subgroup analyses showed no significant association between the 4326C/G polymorphism and PCa aggressiveness. Our meta-analysis showed that CYP1B1 4326G allele is significantly associated with an increased PCa risk in Asians and in sporadic PCa cases.

  9. Prostate cancer risk and aggressiveness associated with the CYP1B1 4326C/G (Leu432Val) polymorphism: a meta-analysis of 2788 cases and 2968 controls

    Institute of Scientific and Technical Information of China (English)

    Jie Yang; Dong-Liang Xu; Qiang Lu; Zhi-Jian Han; Jun Tao; Pei Lu; Chao Wang; Xiao-Ke Di; Min Gu


    To derive a precise estimation of the associations between the cytochmme P450 1B1 (CYP1B1) 4326C/G variants and prostate cancer (PCa) risk or aggressiveness,a meta-analysis was performed using all eligible published studies.Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association in seven literature studies with 2788 cases and 2968 controls.In the overall analysis,no significant association was found between the CYP1B1 4326C/G polymorphism and PCa risk,but ethnicity subgroup analyses and a case-source analysis revealed significant associations.The 4326G allele showed a significant association with increased PCa risk in Asians (OR=1.52,95% Cl:1.20-1.92),and significant associations were also observed in a heterozygote comparison (OR=1.40,95% Cl:1.03-1.89),a homozygote comparison (0R=2.38,95% Ch 1.31-4.33) and in a dominant genetic model (OR =1.52,95% Cl:1.14-2.01).Moreover,the 4326G allele was also significantly correlated with an increased risk of sporadic PCa (OR=1.13,95% Cl:1.04-1.24),and significant associations were observed in a heterozygote comparison (OR=1.16,95% CI:1.02-1.33),a homozygote comparison (0R=1.24,95% Cl:1.03-1.49) and a dominant genetic model (0R=1.19,95% Cl:1.05-1.34).The overall analyses and all subgroup analyses showed no significant association between the 4326C/G polymorphism and PCa aggressiveness.Our meta-analysis showed that CYP1B1 4326G allele is significantly associated with an increased PCa risk in Asians and in sporadic PCa cases.

  10. Dicty_cDB: Contig-U13560-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ), Expect = 0.0 Identities = 495/503 (98%) Strand = Plus / Plus Query: 13 atatggtttaccnacaangattttcagaccaggn...acaatntttagtnanacccaatttgg 72 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 13 atatggtttaccna...attggatngatgntcaacttaatttttc 372 Query: 373 aaataatccnttgtattttattaaacntttatttaaaaanaatgatcgtttcccnattgg 432... |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 373 aaataatccnttgtattttattaaacntttatttaaaaanaatgatcgtttcccna...ttgg 432 Query: 433 ttttcagtcaattaaaaatccnaaaactattaaagattta

  11. Correction: β-Sialon nanowires, nanobelts and hierarchical nanostructures: morphology control, growth mechanism and cathodoluminescence properties (United States)

    Huang, Juntong; Huang, Zhaohui; Liu, Yangai; Fang, Minghao; Chen, Kai; Huang, Yaoting; Huang, Saifang; Ji, Haipeng; Yang, Jingzhou; Wu, Xiaowen; Zhang, Shaowei


    Correction for `β-Sialon nanowires, nanobelts and hierarchical nanostructures: morphology control, growth mechanism and cathodoluminescence properties' by Juntong Huang, et al., Nanoscale, 2014, 6, 424-432.

  12. A High-Temperature Combinatorial Technique for the Thermal Analysis of Materials (United States)


    Thesis, Albert-Ludwigs University, Freiburg, Germany (2003) [13] B. Revaz, B.L. Zink, F. Hellman, Thermochimica Acta 432, 158 (2005) [14] A.A...Minakov, S.A. Adamovsky, C. Schick, Thermochimica Acta 432, 177 (2005) [15] P.F. Sullivan, G. Seidel, Phys. Rev. 173, 679 (1968) [16] S.F. Hsieh, S.K

  13. Dark fermentative hydrogen and ethanol production from biodiesel waste glycerol using a co-culture of Escherichia coli and Enterobacter sp.

    NARCIS (Netherlands)

    Maru, B.T.; López, F.; Kengen, S.W.M.; Constantí, M.; Medina, F.


    In previous comparative studies, Enterobacter spH1 was selected as the best hydrogen and ethanol producer (Knothe, 2010). Here, glycerol fermentation was compared between three other strains: Escherichia coli CECT432, Escherichia coli CECT434 and Enterobacter cloacae MCM2/1. E. coli CECT432 was f

  14. Drug: D00356 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00356 Drug Latanoprost (JAN/USAN/INN); Xalatan (TN) C26H40O5 432.2876 432.5928 D00356.gif Antiglaucoma...eceptor interaction map07035 Prostaglandins map07054 Antiglaucoma agents map07228

  15. 42 CFR 433.15 - Rates of FFP for administration. (United States)


    ...) Administration of family planning services: 90 percent. (Section 1903 (a)(5); 42 CFR 432.50(b)(5).) (3) Design.... (Section 1903(a)(3)(A)(i); 42 CFR part 433, subpart C, and § 432.50 (b)(3).) (4) Operation of mechanized claims processing and information retrieval systems: 75 percent. (Section 1903(a) (3)(B); 42 CFR part...

  16. Toxicity studies for indigenous Bacillus thuringiensis isolates from Malang city, East Java on Aedes aegypti larvae

    Directory of Open Access Journals (Sweden)

    Zulfaidah Penata Gama


    Conclusions: Six indigenous B. thuringiensis isolates among the 33 bacterial isolates found in the Sawojajar and Purwantoro sub-districts were toxic to the third instar larvae of Ae. aegypti. The PWR4-32 isolates were identical to the reference B. thuringiensis and had 88% phenotype similarity. The PWR4-32 isolates had the highest spore prevalence (52.44%, and the early stationary phase occurred at 36 h. The PWR4-32 isolates were the most effective at killing Ae. aegypti larvae (LC50–72 h=2.3×108 cells/mL.

  17. 2006 Volusia County Florida LiDAR (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is the lidar data for Volusia County, Florida, approximately 1,432 square miles, acquired in early March of 2006. A total of 143 flight lines of Lidar...

  18. 2006 Volusia County, Florida Lidar (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is the lidar data for Volusia County, Florida, approximately 1,432 square miles, acquired in early March of 2006. A total of 143 flight lines of Lidar...

  19. 76 FR 16417 - Product Cancellation Order for Certain Pesticide Registrations (United States)


    ... Piperonyl butoxide Permethrin Pyrethrins Pyriproxyfen 002596-00119 Hartz Rabon Flea Garadona (cis- and Tick... Life Sciences, 301 West Osborn Road, Phoenix, AZ 85013. 432 Bayer Environmental Science, 2 T....

  20. International Scientific Technology Exchanges in 2011

    Institute of Scientific and Technical Information of China (English)


    In 2012, CIAE sent 432 scholars abroad for taking part in international meeting, technical visiting, further studying and training. CIAE received more than 300 foreign scholars from about 30 countries, and some reports were given by foreign scholars as follows:

  1. Preparation of aluminium lakes by electrocoagulation


    Prapai Pradabkham


    Aluminium lakes have been prepared by electrocoagulation employing aluminium as electrodes. The electrocoagulation is conducted in an aqueous alcoholic solution and is completed within one hour. The dye content in the lake ranges approximately between 4-32%.

  2. 76 FR 35941 - Offer for Public Sale of Two High Speed Vessels (United States)


    ..., 1200 New Jersey Ave., SE., Room W23-432, Washington, DC 20590, Attention: Mr. Daniel Ladd, by 5 p.m. 30... Transit.. 11.67'. Passengers 836'. Ramp Stern Starboard Quartering. Vehicles Cars 282 (max.) Trucks...

  3. On the Development of Constitutive Relations for Plain and Reinforced Concrete. (United States)


    4.3.1 Variable Modulus Models ............ ... 183 4.3.2 Hypoelastic Models ..... ............. 185 4.3.3 Elastic Plastic Models . .......... .... 186...simplest structures. 4.3.2 Hypoelastic Models Coon and Evans (144 ) starting from the general representation of a hypoelastic material developed an...Recommendations Many models for plain concrete triaxial response have been developed. The variable modulus and hypoelastic theories are of no 194

  4. Association of CYP1B1 gene polymorphisms and the positive expression of estrogen alpha and estrogen beta with endometrial cancer risk. (United States)

    Zhu, Z Y; Mu, Y Q; Fu, X M; Li, S M; Zhao, F X


    To investigate the relationship between the CYP1B1 L432V polymorphism, ERalpha and ERbeta positivities and the incidence of endometrial cancer. The relationship between CYP1B1 L432V polymorphism, ERalpha and ERbeta positivities and endometrial cancer was investigated using the allele-specific polymerase chain reaction method to analyze gene polymorphism in exon 3 codon 432 (C-G) of CYP1B1. Our results are as follows: in endometrial cancer cases the prevalence rates of CYP1B1 L432V genotypes C/C, C/G, and G/G were 47.2%, 36.1%, and 16.7%, respectively, and 68.8%, 23.8% and 7.5% in the control group, respectively. The frequencies of CYP1B1 C and G alleles were 65.3% and 34.7% in endometrial cancer patients and 80.6% and 19.4% in the control group. A significant difference was found in the genotype distributions or allele frequencies of CYP1B1 L432V polymorphism between the two groups (p polymorphism of CYP1B1 L432V increases the risk of endometrial cancer and has a positive correlation with ERalpha expression.

  5. Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily

    Energy Technology Data Exchange (ETDEWEB)

    Gajewski, Stefan; Comeaux, Evan Q.; Jafari, Nauzanene; Bharatham, Nagakumar; Bashford, Donald; White, Stephen W.; van Waardenburg, Robert C.A.M. (UAB); (SJCH)


    Tyrosyl-DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3'-phospho-DNA adducts via two conserved catalytic histidines - one acting as the lead nucleophile and the second acting as a general acid/base. Substitution of the second histidine specifically to arginine contributes to the neurodegenerative disease spinocerebellar ataxia with axonal neuropathy (SCAN1). We investigated the catalytic role of this histidine in the yeast protein (His432) using a combination of X-ray crystallography, biochemistry, yeast genetics, and theoretical chemistry. The structures of wild-type Tdp1 and His432Arg both show a phosphorylated form of the nucleophilic histidine that is not observed in the structure of His432Asn. The phosphohistidine is stabilized in the His432Arg structure by the guanidinium group that also restricts the access of nucleophilic water molecule to the Tdp1-DNA intermediate. Biochemical analyses confirm that His432Arg forms an observable and unique Tdp1-DNA adduct during catalysis. Substitution of His432 by Lys does not affect catalytic activity or yeast phenotype, but substitutions with Asn, Gln, Leu, Ala, Ser, and Thr all result in severely compromised enzymes and DNA topoisomerase I-camptothecin dependent lethality. Surprisingly, His432Asn did not show a stable covalent Tdp1-DNA intermediate that suggests another catalytic defect. Theoretical calculations revealed that the defect resides in the nucleophilic histidine and that the pK{sub a} of this histidine is crucially dependent on the second histidine and on the incoming phosphate of the substrate. This represents a unique example of substrate-activated catalysis that applies to the entire phospholipase D superfamily.

  6. T4噬菌体32蛋白的表达、纯化及鉴定%Expression,Purification and Identification of T4 Bacteriophage 32 Protein

    Institute of Scientific and Technical Information of China (English)

    胡子有; 曾勇; 吴炳义


    Objective To construct the prokaryotic expression plasmid T4-32-pET28b containing T4 bacteriophage 32 protein and to express, purify, and identify the target protein. Methods The full length DNA fragment of 32 protein was amplified from T4 bacteriophage genomic DNA by PCR using high fidelity DNA polymerase. And the PCR product was inserted into the prokaryotic expression plasmid pET28b in oriented cloning. Then, T4-32-pET28b was transformed into BL21 ( DE3) and the expression of the target protein was induced with 1. 0 mmol/L IPTG at 37℃. T4-32 protein was purified from crude extracts using Ni immobilized metal ion affinity chromatography and desalted using Sephadex G-25. The purified T4-32 protein was detected by assays for contamination of bacterial genomic DNA and nucleases. The ability of T4-32 binding single strand DNA was also determined in agarose electrophoresis. Results Restriction enzyme digestion and sequencing showed that the sequence of T4-32 in T4-32-pET28b was correct. The T4-32 protein was successfully expressed in BL21 ( DE3) and highly purified. Conclusion The prokaryotic expression vector T4-32-pET28b, which could be used for expressing large amounts of purified T4-32 protein, was successfully constructed.%目的 构建T4噬菌体32蛋白的原核表达质粒T4-32-pET28b,并表达、纯化和鉴定重组目的 蛋白.方法以T4噬菌体DNA 基因组为模板,PCR扩增得到32蛋白基因片段,定向克隆到原核表达载体pET28b中,转化入大肠埃希菌BL21(DE3)中,用IPTG诱导表达目的 蛋白,然后进行镍柱纯化和G-25脱盐,获得纯化目的 蛋白,并进行核酸酶和细菌基因组污染检测及结合DNA单链能力检测.结果 构建的T4-32-pET28b质粒经酶切及测序鉴定正确,在BL21(DE3)成功表达了T4-32蛋白,经镍柱和脱盐纯化获得了高纯度的目的 蛋白.结论 成功构建了T4噬菌体32蛋白的原核表达载体T4- 32-pET28b,并实现高表达和纯化了目的 表达产物.

  7. Drug: D01619 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01619 Drug Hydrocortisone butyrate (JP16/USP); locoid (TN) C25H36O6 432.2512 432.5... A01AC Corticosteroids for local oral treatment A01AC03 Hydrocortisone D01619 Hydrocortison...TESTINAL ANTIINFLAMMATORY AGENTS A07EA Corticosteroids acting locally A07EA02 Hydrocortisone D01619 Hydrocortison...IDS AND ANAL FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA01 Hydrocortisone D01619 Hydrocortison...NS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone D01619 Hydrocortison

  8. CYP1B1 Polymorphism as a Risk Factor for Race-Related Prostate Cancer. Addendum (United States)


    119 and 432 are greater among Blacks (Pɘ.001) whereas the 453 variant is predominant in Whites (Pɘ.001). Within race, a case control study show the...the 432G-449C haplotype was observed to be a risk for PC (Pɘ.05). In a sampling of cases , no differences were observed between stages (<T2c vs >T2c...hypertrophy (BPH). Relevant clinico -pathologi c data (age, Gleason grade, and tum or-node- 6 metastasis stage) were collected from the patie nt files. The

  9. Genetic and bibliographic information: AIF1 [GenLibi

    Lifescience Database Archive (English)

    Full Text Available ion (MeSH) Digestive System Diseases (C06) > Gastrointestinal Diseases (C06.405) > Gastroenteritis (C06.405....205) > Inflammatory Bowel Diseases (C06.405.205.731) > Crohn Disease (C06.405.205.731.500) Digestive System Diseases... (C06) > Gastrointestinal Diseases (C06.405) > Intestinal Diseases (C06.4...05.469) > Inflammatory Bowel Diseases (C06.405.469.432) > Crohn Disease (C06.405.469.432.500) Cardiovascular Diseases...280.647.500) Cardiovascular Diseases (C14) > Vascular Diseases (C14.907) > Myocar

  10. New treatment of early fetal chylothorax

    DEFF Research Database (Denmark)

    Nygaard, Ulrikka; Sundberg, Karin; Nielsen, Henriette Svarre


    OBJECTIVE: To evaluate OK-432, a preparation of Streptococcus pyogenes, in the treatment of early fetal chylothorax. METHODS: A prospective study of all fetuses (n=7) with persistent early chylothorax (gestational ages 16-21 weeks) referred to the tertiary center of fetal medicine in Denmark in 2...... effusions, lung hypoplasia, or hydrops. CONCLUSION: Persistent early chylothorax is a condition with a high mortality rate and no established treatment option. Use of OK-432 is a promising therapy for selected fetuses with persistent chylothorax early in the second trimester....

  11. Власть и прибыль. Купец в средневековой Европе


    Смирнова, Е. Д.; Шабан, А.И.


    Рец. на кн.: P. Spufford. Power and Profit. The merchant in Medieval Europe. London: Thames & Hudson, 2002. 432 р. = П. Спаффорд . Власть и прибыль. Купец в средневековой Европе. Лондон, 2002. 432 с.

  12. Identification of Two Chlorpyrifos-degrading Strains and the Effect of Bacterial Fermentation on Seed Germination of Radish%两株毒死蜱降解细菌菌株鉴定及对萝卜种子萌发的影响

    Institute of Scientific and Technical Information of China (English)

    任艳; 张新建; 李红梅; 黄玉杰; 李纪顺; 杨合同


    鉴定两株有较强降解毒死蜱能力的菌株N16和N432,并初步探讨此两株细菌菌液对萝卜种子萌发的影响.通过对其形态、生理生化特征及16S rDNA的分析,进行初步鉴定;以不同浓度的菌液浸泡萝卜种,之后于25℃下培养,测定发芽势、发芽率、发芽指数、活力指数.通过形态特征及序列分析,这两株菌均为琼氏不动杆菌属(Acinetobacter junii).N16细菌原液对萝卜种子发芽率、发芽指数均高于对照组,N432作用完全相反.菌株N16对萝卜种子的萌发具有促进作用,这种促进作用随着培养液的稀释,呈现逐渐降低的趋势.而菌株N432则对种子的萌发具有抑制作用,并且这种抑制作用随着培养液的稀释呈现减弱趋势.%Two bacterial strains N16, N432 which could degrade chlorpyrifos were identified, and the effect of the fermentation liquid from the strains on sprout and seeding of radish was studied. The strains were identified based on the morphological, physiological, biochemical characteristic and 16S rDNA sequences. The radish seed treated with the fermentation liquid at 251 were cultures, and then germination energy, germination rate, germination index, vigor index were measured. It is showed that N16, N432 were identified as Acinetobacter junii according to the morphological characteristic and sequencing. Germination energy, germination rate, germination index, vigor index of radish seeds pretreated with pure bacteria liquid of N16 were higher than control, but they were inhibited by the N432. Germination rate and germination index were promoted by the liquid culture of N16, but they were inhibited by the liquid culture of N432. And the effects including inhibition of N432 and enhancement of N16 would be weakened when their liquid cultures were diluted.

  13. NIF PEPC Mechanical Test Stand Safety Note

    Energy Technology Data Exchange (ETDEWEB)

    Trent, J W


    The NIF PEPC Mechanical Test Stand is to be used in the building 432. Building 432 is being used to test components and processes for NIF. The test stand is to be bolted to the floor. The test stand provides a platform from which the PEPC kinematic repeatability and vibrational characteristics of the PEPC LRU can be tested. The test stand will allow user access to the LRU to install instrumentation and to make adjustments to the kinematics. The mechanical test stand is designed to hold the 1700 lb. PEPC LRU.

  14. AcEST: DK949432 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 5. 5' end sequence. DK949432 CL2Contig2 Show DK949432 Clone id TST38A01NGRL0005_P15 Library TST38 Length 698... Definition Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0005_P15. 5' end sequence. Accession DK949432...ein database search programs, Nucleic Acids Res. 25:3389-3402. Query= DK949432|Ad...IGSVYREHFHGSGYYDGRYWVMWKLPMFGCQDAAAVL 432 ++K++D+++R W PC+EF+ + G VYREH H GYYDGRYW MWKLPMFGC D+A V+ Sbjct: 8...WPPFGNPKFETLSYLPTLTE 74 Query: 253 EQIAKQVDFMVRKGWTPCIEFDKIGSVYREHFHGSGYYDGRYWVMWKLPMFGCQDAAAVL 432 EQ+ K+V+

  15. Military Specification, Modules, Standard Electronic Memory Array, 128K Dynamic Random Access Module, Key Code JEJ (United States)


    applicable. PSFC «= power supply filter capacitance. PSTA = power supply transient amplitude. Vic = input clamp diode voltage. Vih = input high...3.46 W (typical) 16 MIL-M-28787/432 6.3.1 Input pa ran eters. Signal Vic min (V) Vil max (V) Vih min (V) lil min (mA) lih max (mA...MEM ADRS B 1 -1.2 0.4 2.4 -1.2 0.04 0.2 75 17 MIL-M-28787/432 6.3.1 Input parameters - continued. Signal Vic min (V) Vil max (V) Vih

  16. In-building Unlicensed WiFi Band OFDM Signal Distribution over MMF&BIF Using VCSEL

    DEFF Research Database (Denmark)

    Deng, Lei; Jensen, Jesper Bevensee; Yu, Xianbin


    For in-building applications, an OFDM-VCSEL RoF system operating in unlicensed WiFi band is experimentally tested using MMF and bend insensitive fiber (BIF). A spectral efficiency of 4.32 bit/s/Hz with 0.9 Gbps data rate is achieved.......For in-building applications, an OFDM-VCSEL RoF system operating in unlicensed WiFi band is experimentally tested using MMF and bend insensitive fiber (BIF). A spectral efficiency of 4.32 bit/s/Hz with 0.9 Gbps data rate is achieved....

  17. A 657-nm narrow bandwidth interference filter-stabilized diode laser

    Institute of Scientific and Technical Information of China (English)

    Zhengbo Wang; Xiaokai Lü; Jingbiao Chen


    We present a 657-nm external cavity diode laser (ECDL) system, where the output frequency is stabilized by a narrow-band high transmission interference filter. This novel diode laser system emits laser with an instantaneous linewidth of 7 kHz and a broadened linewidth of 432 kHz.%@@ We present a 657-nm external cavity diode laser (ECDL) system, where the output frequency is stabilized by a narrow-band high transmission interference filter.This novel diode laser system emits laser with an instantaneous linewidth of 7 kHz and a broadened linewidth of 432 kHz.

  18. Integrated Biological Warfare Technology Platform (IBWTP). Intelligent Software Supporting Situation Awareness, Response, and Operations (United States)


    21 4.3.1. Existing Biosurveillance Systems .............................................................. 22 4.3.2. Automatic Integration...Expert Team Risk Assessment Emergency Plans Command Centers IPE – Intelligent Portal - IPE Interactive Knowledge Wall Presentation Collaboration...such as existing biosurveillance systems, information produced via technological approaches can be incorporated into IBWTP in a fairly transparent

  19. What Sexual Harassment Experiences Lead Respondents to Acknowledge Being Sexually Harassed? A Secondary Analysis of a University Survey. (United States)

    Stockdale, Margaret S.; Vaux, Alan


    According to survey responses from 933 of 1,807 undergraduates, 227 of 1,006 graduate students, and 432 of 1,372 faculty/staff, experience of sexual seduction, coercion, or imposition increased the probability of acknowledgment of having been harassed. Probability of acknowledgment was not related to gender or form of harassment. (SK)

  20. 色度学理论

    Institute of Scientific and Technical Information of China (English)


    O432.3 2000042274符合人眼视觉特性的颜色亮度模型=A color brightnessmodel fitting characteristics of human vision[刊,中]/刘伟奇,冯睿,周丰昆(中科院长春光机所应用光学国家重点实验室.吉林,长春(130022))//光

  1. Dietary fat intake and subsequent weight change in adults: results from the European Prospective Investigation into Cancer and Nutrition cohorts

    DEFF Research Database (Denmark)

    Forouhi, Nita G; Sharp, Stephen J; Du, Huaidong;


    weight divided by duration of follow-up). DESIGN: We analyzed data from 89,432 men and women from 6 cohorts of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Using country-specific food-frequency questionnaires, we examined the association between baseline fat intake...

  2. Farmer Perceptions of Soil and Water Conservation Issues: Implications to Agricultural and Extension Education. (United States)

    Bruening, Thomas; Martin, Robert A.


    A survey of 731 Iowa farmers received 432 responses indicating that (1) groundwater and water quality were of greater concern than soil conservation; (2) field demonstrations and county meetings were useful information sources on these issues; and (3) government agencies such as cooperative extension and state universities were useful sources of…

  3. 77 FR 29753 - CaterParrott Railnet, L.L.C.-Sublease and Operation Exemption-Georgia & Florida Railway, L.L.C. (United States)


    ...] CaterParrott Railnet, L.L.C.--Sublease and Operation Exemption-- Georgia & Florida Railway, L.L.C. CaterParrott Railnet, L.L.C. (CPR), a noncarrier, has filed a verified notice of exemption under 49 CFR 1150.31 to sublease from Georgia & Florida Railway, L.L.C. (GRF) and operate approximately 43.2 miles of...

  4. Distinguishing Internet-facing ICS Devices Using PLC Programming Information (United States)


    automated by use of web - scraping techniques. These techniques make an HTTP GET request for the Diagnostic Web Page and search the web page source code...devices . . . . . . . . . . . . . . . 73 4.3.2 Collecting Diagnostic Web Page Data . . . . . . . . . . . . . . . . 75 4.3.3 Collecting PLC Code...EtherNet/IP Architecture [25]. . . . . . . . . . . . . . . . . . . 15 2.7 EtherNet/IP Module Web Server

  5. 78 FR 64260 - Public Hearing (United States)


    .../2009-02%20Access%20to%20Records%20Policy%209-10-09.PDF . Opportunity To Appear and Comment Interested... groundwater withdrawal of up to 0.432 mgd (30-day average) from Mifflinville Well 3 (Docket No. 19960902). 2... of groundwater withdrawal of up to 0.115 mgd (30-day average) from Well 6 (Docket No. 20000203)....

  6. Public Attitudes toward Reporting Partner Violence against Women and Reporting Behavior (United States)

    Gracia, Enrique; Herrero, Juan


    Drawing from attitude-behavior research tradition, this study used a national probabilistic sample of the Spanish adult population (N = 2,432) to test hypotheses regarding correlates of public attitudes toward reporting partner violence against women, and the relationship between attitudes toward reporting and actual reporting behavior. Results…

  7. Dicty_cDB: Contig-U14921-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available A4 alpha... 514 e-144 DQ980509_1( DQ980509 |pid:none) Thaumatomonas sp. TMT002 alpha tub... 514 e-144 EF432...1 e-140 DQ980507_1( DQ980507 |pid:none) Synura sphagnicola clone sptua3 al... 501 e-140 EF455794_1( EF455794 |pid:none) Thaumatomo

  8. Prevalence of hemoprotozoan diseases in cattle population of chittagong division, Bangladesh

    DEFF Research Database (Denmark)

    Alim, Md. Abdul; Das, Shubhagata; Roy, Krisna;


    A one year (2009-10) prevalence study on hemoprotozoan diseases was conducted in crossbred and indigenous cattle, Chittagong, Bangladesh. Blood samples were collected randomly from 216 crossbred and 432 indigenous cattle of four representative areas in three consecutive seasons. Samples were...

  9. Compilation of Abstracts of Theses Submitted by Candidates for Degrees. (United States)


    Trend by the Civilian Sector Towards 40 Foot Containers Norton, J.A. Excellence Within the Navy 308 LT, USN Health Care System XXX ~Page MANAGEMENT...Engineer Allocation 432 CPT, USA Model Kiziltan, M. Cognitive Performance Degrada- 433 LTJG, Turkish Navy tion on Sonar Operator and Tor- pedo Data

  10. Genital forekomst af Chlamydia trachomatis hos abortsøgende--korrelerer med ung alder og nulliparitet, men ikke tidligere underlivsbetoendelse

    DEFF Research Database (Denmark)

    Sørensen, Jette Led; Thranov, I R; Hoff, G E


    Out of 432 women applying for termination of pregnancy, 7.9% (34/428) had cervical Chlamydia trachomatis and 0.7% (3/431) genital Neisseria gonorrhoeae. The prevalence of Chlamydia was 19.2% among the women applying for termination who were under 20 years and 12.8% among those aged 21-25 years...

  11. Fruit and vegetable intakes and subsequent changes in body weight in European populations: results from the project on Diet, Obesity, and Genes (DiOGenes)

    DEFF Research Database (Denmark)

    Buijsse, Brian; Feskens, Edith J M; Schulze, Matthias B;


    : The data used were from 89,432 men and women from 5 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). The association between fruit and vegetable intake and weight change after a mean follow-up of 6.5 y was assessed by linear regression. Polytomous logistic...

  12. Explosives Detection in a Lasing Plasmon Nanocavity (United States)


    2014; published online 20 July 2014 References 1. Peng, G. et al. Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nature Nanotech . 4...Zhu, J., Kim, W. & Yang, L. Detecting single viruses and nanoparticles using whispering gallery microlasers. Nature Nanotech . 6, 428–432 (2011). 22

  13. Competencies of Nigerian Graduate Teachers: The Insiders' Perspectives (United States)

    Wodi, Iniye Irene; Oluwatayo, Gbenga Kayode; Onyima, Nonye Blessing


    The study was carried out to establish the competencies of graduate teachers who graduated from teacher education programs between the year 2005 and 2010. Multi-stage sampling was used in selecting 432 respondents comprising educational administrators and graduate teachers working in the three levels of education across two states of Southern…

  14. Disease: H00464 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ndrome; Ear-patella-short statute syndrome Patella dysplasias are a group of disorders that include aplasia/hypoplasia...oplasia: a rare constituent of congenital syndromes. Acta Orthop Belg 69:29-34 (200... the nail-patella syndrome. Pediatr Radiol. 27:432-5 (1997) PMID:12666288 (description) Sferopoulos NK, Tsitouridis I Ischiopubic hyp

  15. Dicty_cDB: Contig-U04690-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available from Patent WO02070737. 44 5.8 1 ( AC004028 ) Homo sapiens PAC clone RP4-800B9 from 7, complete... 44 5.8 1 ( AC153098 ) Carol...lia perspicillata clone 432B2, WORKING DRAFT... 44 5.8 1 ( AC152359 ) Carol

  16. Conducting SEI (Software Engineering Institute)-Assisted Software Process Assessments (United States)


    4.1. Executive-Level Briefing 13 4.2. The Assessment Agreement 13 4.3. Assessment Team 14 4.3.1. Assessment Team Roles 14 4.3.2. Criteria for Selecting...assessment team members. 4.3.1. Assessment Team Roles In an SEI-assisted assessment, the assessment team consists of an assessment team leader, an SEI

  17. 色度学理论

    Institute of Scientific and Technical Information of China (English)


    O432.3 2004031627 一种计算色度学三刺激值加权表的新方法=A simplemethod for computing optimum weighting table for colorimetric tristimulus integration[刊,中]/李长军(中科院沈阳自动化研究所.辽宁.沈阳(110015)),崔桂华…∥光

  18. 34 CFR 685.402 - Criteria for schools to originate loans. (United States)


    ..., not be on the reimbursement system of payment. (iii) In the opinion of the Secretary, have had no... IV program needs. (vii) Have no material findings in any of the annual financial audits submitted for... proposed or final limitation, suspension, or termination action under sections 428(b)(1)(T), 432(h), or...

  19. Strategic Leaders: It’s Time to Meet the Press (United States)


    December 2001), 40. 72 Richard Parker, "The Future of Global Television on Economic Perspectives," Political Communication , 12 (October-December 1995...34 Political Communication , 12 (October-December 1995), 432. In Gary S. Patton, "Public Affairs and Information Operations: Integral or Incompatible

  20. Runoff Responses to Forest Thinning at Plot and Catchment Scales in a Headwater Catchment Draining Japanese Cypress Forest (United States)

    We examined the effect of forest thinning on runoff generation at plot and catchment scales in headwater basins draining a Japanese cypress (Chamaecyparis obtusa) forest. We removed 58.3% of the stems (corresponding to 43.2% of the basal area) in the treated headwater basin (catc...

  1. Repeating a Monologue under Increasing Time Pressure: Effects on Fluency, Complexity, and Accuracy (United States)

    Thai, Chau; Boers, Frank


    Studies have shown that learners' task performance improves when they have the opportunity to repeat the task. Conditions for task repetition vary, however. In the 4/3/2 activity, learners repeat a monologue under increasing time pressure. The purpose is to foster fluency, but it has been suggested in the literature that it also benefits other…

  2. The Royal Aircraft Establishment - 100 Years of Research. (United States)


    OF RESIARCH.(U) OCT 61 A J SMITH UNCLASSIFIED RAE-TN-FS-432 DRIC-BR-80894 NLslomommmmoimco IE-E,,.IuENE 1111U1IIIjj -. ’ jI2 MICROCOPY RESOLUTION TESI ...Aircraft Estpblishment - 100 years of research 7a. (For Translations ) .Title in Foreign Language 7b. (For Conference Papers) Title, Place and Date of

  3. Copper Soldiers: Forging New Roles for the Chilean Military (United States)


    Desierto: Una Memoria diplomatica," Hispanic American Historical Review, 81 (May 2001): 431-432. 93 Commander Luis de la Fuente, Argentine Navy...Internet; accessed 21 June 2005. William F. Sater, “Engima de la Laguna del Desierto: Una Memoria diplomatica, Hispanic American Historical Review

  4. Heritage, Image and Identity: The Evolution of USAF Leadership (United States)


    USAF ramped up production of RPA and associated Intelligence , Surveillance and Reconnaissance (ISR) infrastructure. 27 Colonel Pete Gersten, the 432...This organizational condition leans towards myopia and monistic thinking, often manifested in a consuming focus on a purpose or mission that favors

  5. Corporal Punishment and Child Behavioural and Cognitive Outcomes through 5?Years of Age: Evidence from a Contemporary Urban Birth Cohort Study (United States)

    MacKenzie, Michael J.; Nicklas, Eric; Waldfogel, Jane; Brooks-Gunn, Jeanne


    This study examined the prevalence and determinants of spanking of children at 3?years of age and the associations between spanking and externalizing behaviour and receptive verbal ability at age 5?years. Overall, we find maternal spanking rates of 55.2% and paternal rates of 43.2% at age 3?years. Mothers facing greater stress and those who…

  6. Danish surgeons' views on minimally invasive surgery

    DEFF Research Database (Denmark)

    Edwards, Hellen; Jørgensen, Lars Nannestad


    that the risk was equal to traditional laparoscopy (3%). The fraction of surgeons willing to learn SILS and NOTES was 44.6% and 32.7%, respectively. The desire to learn was higher among less experienced and surgically active surgeons. Of the responders, 68.8% considered SILS and 43.2% considered NOTES would...

  7. Can New Inflammatory Markers Improve the Diagnosis of Acute Appendicitis?

    DEFF Research Database (Denmark)

    Andersson, Manne; Rubér, Marie; Ekerfelt, Christina;


    , and myeloperoxidase [MPO]) were compared with traditional diagnostic variables included in the Appendicitis Inflammatory Response (AIR) score (right iliac fossa pain, vomiting, rebound tenderness, guarding, white blood cell [WBC] count, proportion neutrophils, C-reactive protein and body temperature) in 432 patients...

  8. Architectural Survey of Laramie Armory, Wyoming Army National Guard (United States)


    reports published by ERDC, visit the ERDC online library at Cover Photo: Laramie Armory, looking east toward...Maintenance Shop was built in 1961. This survey satisfies Section 110 of the National Historic Preservation Act of 1966 as amended, and it was used to...32 4.3.2 Field Maintenance Shop

  9. Variation in the Helical Structure of Native Collagen (United States)


    Hongo C, Noguchi K (2006) Helical twists of collagen model peptides. Biopolymers 84: 421–432. 39. Kramer R, Bella J, Mayville P, Brodsky B, Berman H...Iguchi M, Noguchi K (2006) Revision of collagen molecular structure. Biopolymers 84: 181–191. 43. Shoulders MD, Raines RT (2009) Collagen structure

  10. A case with Lichen planus in the lines of Blaschko

    Directory of Open Access Journals (Sweden)

    Metehan Gençoğlu


    Full Text Available Lichen planus is an inflammatory disorder that may involveskin and mucous membranes. Linear lichen planusis a rare disorder occurring in approximately 0.2% of patientswith lichen planus. We report a case of linear lichenplanus on the upper extremity which lesions followed thelines of Blaschko. J Clin Exp Invest 2011; 2 (4: 430-432

  11. AcEST: DK960142 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 0.092 sp|Q9P278|FNIP2_HUMAN Folliculin-interacting protein 2 OS=Homo s... 33 1.3 sp|Q11HB8|SYR_MESSB Arginyl...DFRKVSGLLEGSI 432 L V RC + GPGL +N+ D +K + EG I Sbjct: 847 GPVLEPVAPRCVQRGPGLVAGANIPCGDDNKKANFRTEGDI 887 >sp|Q11HB8|SYR_MESSB

  12. The Effects of Slip Character and Crack Closure on the Growth of Small Fatigue Cracks in Titanium-Aluminium Alloys (United States)


    sure they were "puzzled" by my approach. Finally, I would like to thank, gratefully, my wife Elizabeth , who never wavered in her patience and...American Society for Metals, Metals Park, OH, 1974, pp. 409-432. 232 N. E. Paton, J. C. Williams, and G. P. Rauscher . "The Deformation of Alpha-Phase

  13. Does a Claims Diagnosis of Autism Mean a True Case? (United States)

    Burke, James P.; Jain, Anjali; Yang, Wenya; Kelly, Jonathan P.; Kaiser, Marygrace; Becker, Laura; Lawer, Lindsay; Newschaffer, Craig J.


    The purpose of this study was to validate autism spectrum disorder cases identified through claims-based case identification algorithms against a clinical review of medical charts. Charts were reviewed for 432 children who fell into one of the three following groups: (a) more than or equal to two claims with an autism spectrum disorder diagnosis…

  14. Final Environmental Assessment (EA) for Replacement of the Wastewater Lift Station (Building 510) (United States)


    approximately 432 square feet and contains two pumps, various valves , and electrical equipment necessary to pump wastewater from a lower to higher elevation... Butterfly Plant, or either of these species’ associated habitats. It is our understanding that this satisfies our responsibilities under Section ?(c) of

  15. Environmental Assessment (EA) for Replacement of the Wastewater Lift Station (Building 510) (United States)


    approximately 432 square feet and contains two pumps, various valves , and electrical equipment necessary to pump wastewater from a lower to higher elevation... Butterfly Plant, or either of these species’ associated habitats. It is our understanding that this satisfies our responsibilities under Section ?(c) of

  16. Linking Dynamics of the Near-surface Flow to Deeper Boundary Layer Forcing in the Nocturnal Boundary Layer (United States)


    Giancoli , 2000, pgs 432-435) is Vr = c 2 ( 1− fs fe ) (3.7) where fe is the emitted frequency and c is the speed of sound. In the case of a SODAR system...Crescenti, G. H., 1998: The degradation of doppler sodar performance due to noise: A review. Atmos. Environ., 32, 1499–1509. Giancoli , D., 2000

  17. EST Table: NM_001142927 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available NM_001142927 Kynu 10/09/29 100 %/426 aa ref|NP_001136399.1| kynureninase [Bombyx mori] dbj|BAH03383.1| kynur...eninase [Bombyx mori] 10/09/13 n.h 10/08/29 32 %/432 aa C15H9.7#CE06835#WBGene00015802#kynure

  18. Data of evolutionary structure change: 1B38A-1WBSA [Confc[Archive

    Lifescience Database Archive (English)


  19. Vivenciar a com-paixão: a missão na América Latina diante o século 21 [resenha

    Directory of Open Access Journals (Sweden)

    Helmut Renders


    Full Text Available Book review of ZWETSCH, Roberto E. Missão como com-paixão: para uma teologia da missão em perspectiva latino-americana. São Leopoldo / Quito: Sinodal / CLAI, 2008. 432p. [Translation: Mission as com-passion: towards a Theology of Mission in Latin American perspective].

  20. 78 FR 25438 - Product Cancellation Order for Certain Pesticide Registrations (United States)


    ... Brand 2% Propoxur Bait. 000499-00532 TC 277 Piperonyl butoxide, Pyrethrins (No Inert Use). 007173-00283..., Philadelphia, PA 19103. 432 Bayer Environmental Science, 2 T.W. Alexander Dr., P.O. Box 12014, Research Triangle Park, NC 27709. 499 Whitmore Micro-Gen Research Laboratories, Inc., Agent: BASF Corporation...

  1. Clinton, Trump In A Tie. (United States)


    Forty-seven percent of the 432 respondents to our online survey said they plan to vote for Clinton, and the exact same percentage said they intend to vote for Trump. Most respondents thought Trump would do a better job making the system more efficient. A clear majority said that Clinton would do better job limiting cost shifting to consumers.


    Institute of Scientific and Technical Information of China (English)


    <正>20071077 An Zuoxiang(Petroleum Industry Press,Beijing 100011,China);Ma Ji On Bo- real-Style Petroliferous Domain(Xinjiang Petroleum Geology,ISSN1001-3873,CN65 -1107/TE,26(4),2005,p.432-436,4 illus.,9 refs.,with English abstract) Key words:oil and gas fields

  3. Temporal issues in e-learning research: A literature review

    NARCIS (Netherlands)

    Barbera, Elena; Gros, Begona; Kirschner, Paul A.


    Barbera, E., Gros, B., & Kirschner, P. A. (2012). Temporal issues in e-learning research: A literature review. British Journal of Educational Technology, 43(2), E53-E55. doi:10.1111/j.1467-8535.2011.01255.x.

  4. Electrochemical and spectroscopic investigations of the K2SO4-V2O5 molten electrolyte

    DEFF Research Database (Denmark)

    Schmidt, Douglas S.; Winnick, Jack; Boghosian, Soghomon;


    . Most reductions and oxidations did not conform to diffusion-limited theory, and indicated the presence of shipping reactions. By Raman spectroscopy V(V) polymers were identified in the melt consisting predominantly of VO2(SO4)(3)(2-) and VO3- units, while VO2SO4- units were also detected. By reduction...

  5. Efficacy of the Social Skills Improvement System Classwide Intervention Program (SSIS-CIP) Primary Version (United States)

    DiPerna, James Clyde; Lei, Puiwa; Bellinger, Jillian; Cheng, Weiyi


    A multisite cluster randomized trial was conducted to examine the effects of the Social Skills Improvement System Classwide Intervention Program (SSIS-CIP; Elliott & Gresham, 2007) on students' classroom social behavior. The final sample included 432 students across 38 second grade classrooms. Social skills and problem behaviors were measured…

  6. The United States Air Force Academy’s First Twenty-Five Years, Some Perceptions. (United States)


    263 (Introduction to Life Science), Life Sci 431-432 ( Microbiology I & II), and Life Sci 461-462 (Developmental Anatomy I & II). II Lt Col John R...The Ecuador -Peru Dispute; and (with Robin Higham) A Short History of Warfare. .-. ? 170 Dean of the Faculty sponsored by the National Archives to

  7. A New In Vitro Model of Breast Cancer Metastasis to Bone (United States)


    2008) 27:41–55 70. Scott, L. J., Clarke, N.W., George, N. J., Shanks, J. H., Testa , N. G., & Lang, S. H. (2001). Interactions of human prostatic...structural alterations of bones in heparin-induced osteoporosis. Clin Rheumatol, 22, 432-6. 23 38. Moreno- Reyes , R., Egrise, D., Neve, J., Pasteels

  8. Reliability and Validity of a Measure of Preschool Teachers' Attributions for Disruptive Behavior (United States)

    Carter, Lauren M.; Williford, Amanda P.; LoCasale-Crouch, Jennifer


    Research Findings: This study examined the quality of teacher attributions for child disruptive behavior using a new measure, the Preschool Teaching Attributions measure. A sample of 153 early childhood teachers and 432 children participated. All teachers completed the behavior attributions measure, as well as measures regarding demographics,…

  9. Preparation of aluminium lakes by electrocoagulation

    Directory of Open Access Journals (Sweden)

    Prapai Pradabkham


    Full Text Available Aluminium lakes have been prepared by electrocoagulation employing aluminium as electrodes. The electrocoagulation is conducted in an aqueous alcoholic solution and is completed within one hour. The dye content in the lake ranges approximately between 4-32%.

  10. 7 CFR 1767.23 - Interest charges. (United States)


    ... Companies 431Other Interest Expense 432Allowance for Borrowed Funds Used During Construction—Credit Interest... amortization of unamortized debt discount and expense on outstanding long-term debt. Amounts charged to this... Reacquired Debt A. This account shall include the amortization of the losses on reacquisition of...

  11. Dicty_cDB: AFL694 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 188 2e-43 1 ( AU051937 ) Dictyostelium discoideum slug cDNA, clone SSC432. 62 2e-27 4 ( DD010735 ) Diagnosis of known genetic Parame...ters within the ... 38 0.014 2 ( AX344550 ) Sequence 1 f

  12. Chicagoland Single-Family Housing Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Spanier, J.; Scheu, R.; Brand, L.; Yang, J.


    In this report, the PARR team identifies housing characteristics and energy use for fifteen housing types (groups) in the Chicagoland (Cook County, Illinois) region and specifies measure packages that provide an optimum level of energy savings based on a BEopt analysis. The analysis is based on assessor data and actual energy consumption data on 432,605 houses representing approximately 30% of the population.

  13. Chicagoland Single-Family Housing Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Spanier, J. [Partnership for Advanced Residential Retrofit (PARR), Des Plaines, IL (United States); Scheu, R. [Partnership for Advanced Residential Retrofit (PARR), Des Plaines, IL (United States); Brand, L. [Partnership for Advanced Residential Retrofit (PARR), Des Plaines, IL (United States); Yang, J. [Partnership for Advanced Residential Retrofit (PARR), Des Plaines, IL (United States)


    In this report, the PARR team identifies housing characteristics and energy use for fifteen housing types in the Chicagoland (Cook County, Illinois) region and specifies measure packages that provide an optimum level of energy savings based on a BEopt analysis. The analysis is based on assessor data and actual energy consumption data on 432,605 houses representing approximately 30% of the population.

  14. Intergrated dental care in nursing homes

    NARCIS (Netherlands)

    Gerritsen, P.F.M.


    The thesis deals with integrated dental care in nursing homes. First, the dental treatment needs were ascertained of 432 residents in three Dutch nursing homes that offer integrated dental care. Dentist researchers intra-orally examined the residents and found that 72% required dental treatment. How

  15. Prevalence of Autism Spectrum Disorders in Guanajuato, Mexico: The Leon Survey (United States)

    Fombonne, Eric; Marcin, Carlos; Manero, Ana Cecilia; Bruno, Ruth; Diaz, Christian; Villalobos, Michele; Ramsay, Katrina; Nealy, Benjamin


    There are no epidemiological data on autism for Mexico. This study was conducted to generate a first estimate of ASD prevalence in Mexico. We surveyed children age eight in Leon (Guanajuato). The sample was stratified in two strata: (1) children having special education and medical records (SEMR; N = 432) and (2) children attending regular schools…

  16. File list: DNS.Oth.20.DNase-Seq.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Oth.20.DNase-Seq.AllCell hg19 DNase-seq DNase-Seq Others SRX201256,SRX040399,SR...432 ...

  17. Ultra High Quality Factor Microtoroid for Chemical and Biomedical Sensing Applications (United States)


    The parasites 61 utilize host-hemoglobin and release free- heme (Fe2+-protoporphyrin IX) which is subsequently converted into insoluble...pp. 428-432, 2011. [65] S. Pagola, P. W. Stephens, D. S. Bohle, A. D. Kosar, and S. K. Madsen, "The structure of malaria pigment beta-haematin

  18. Beaked Whale Strandings and Naval Exercises (United States)


    e del Museo Civico di Storia Naturale di Milano, 129(4), 411-432. Centro Studi Cetacei. (1995). Cetacei spiaggiati lungo de coste Italiane. VII...Rendiconto 1992. Atti della Società Italiana di Scienze Naturali e del Museo Civico di Storia Naturale di Milano, 134(2), 285-298. Cote, O. R. (2000

  19. Domain Modeling: NP_663613.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available 25-hydroxycholesterol c1zhxa_ chr11/NP_663613.1/NP_663613.1_holo_292-709.pdb swppa 316L,319V,321L,325V,331F,334K,338Y,372K,376I,377K,378K,379P,432I,438F,447L,471C,479M,481L HC3 0 ...


    Institute of Scientific and Technical Information of China (English)


    2004001 Renal dysfunction in workers exposed to arsenic and cadmium. HONG Feng (洪峰), et al. Dept Occup Health & Toxicol, Public Health Sch, Fudan Univ, Shanghai 200032. Chin J Ind Hyg Occup Dis 2003;21(6) : 432-436.Objective: To examine the nephrotoxicity induced by


    NARCIS (Netherlands)



    In addition to the static cubic lattice model for photon migration in turbid biological media by Bonner et al. [J. Opt. Soc. Am. A 4, 423-432 (1987)], a dynamic method is presented to calculate the average absolute Doppler shift as a function of the distance between the point of injection of photons

  2. A Review of Marine Growth Protection System (MGPS) Options for the Royal Australian Navy (United States)


    DSTO-TR-2631 2.5.2 Protection or remediation  Mexel® 432 is a “ molecular level” filming agent of proprietary formulation which is marketed as...Salinity and temperature tolerances of the green and brown mussels, Perna viridis and Perna perna (Bivalvia: Mytilidae). Revista de Biologia Tropical

  3. Reseñas

    Directory of Open Access Journals (Sweden)

    Eduardo Sáenz Rovner


    Full Text Available María Eugenia Rojas de Moreno, Rojas Pinllla mi padre, Panamericana Formas e Impresos, Bogotá, 2000, 500 pp. /  Jorge Serpa Erazo, Rojas Pinilla. Una historia del siglo XX, Planeta Colombiana, Bogotá, 1999, 537 pp. / Antonio Montaña, Los dias del miedo, Intermedio Editores, Bogotá, 2000, 432 pp.

  4. The Stability and Reliability of a Modified Work Components Study Questionnaire in the Educational Organization. (United States)

    Miskel, Cecil; Heller, Leonard E.

    The investigation attempted to establish the factorial validity and reliability of an industrial selection device based on Herzberg's theory of work motivation related to the school organization. The questionnaire was reworded to reflect an educational work situation; and a random sample of 197 students, 118 administrators, and 432 teachers was…

  5. 11 CFR 114.6 - Twice yearly solicitations. (United States)


    ..., and may not participate in the decision making process whereby the separate segregated fund makes... organizations making the combined mailing. (2 U.S.C. 431(8)(B)(iii), 432(c)(3), 438(8)(a)) ... Federal Elections FEDERAL ELECTION COMMISSION GENERAL CORPORATE AND LABOR ORGANIZATION ACTIVITY §...

  6. Personal news

    NARCIS (Netherlands)



    Dr. J.A.R. Anderson, former conservator of Forests, Kuching, now consultant forester and ecologist, new address: 30 Greenhill Gardens, Edinburgh EH10 4BP, U.K. His Far East address: c/o Room 432, 4th floor, Katong Shopping Centre, Singapore 15. Dr. P.S. Ashton of Aberdeen spent months in Kuala Lumpu

  7. Analytical Method Details (MS): SE2_MS3 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available 00.0-1500.0); 2: ITMS + c norm !corona !pi Dep MS/MS Most intense ion from (1)., Rejected mass=284.2000;300.2000;328.2000;344.2000;372.2000;388.2000;416.3000;432.3000;460.0000. ...

  8. Afløbsinstallationer - systemer og dimensionering

    DEFF Research Database (Denmark)

    Brandt, Erik; Faldager, Inge

    SBi-anvisning 255 beskriver afløbssystemer og retningslinjer for dimensionering af afløbssystemer i henhold til Bygningsreglementet og derigennem DS 432:2009. Anvisningen henvender sig til projekterende og udførende af afløbsinstallationer i nybyggeri eller eksisterende byggeri, eller som skal...

  9. Computer Generated Holography as a Three-Dimensional Display Medium (United States)


    series of two dimensional images are reflected on an object screen resulting in an autostereoscopic , or true three dimensional, images. The advantages attractive target to optimize. Jack Ritter has suggested a fast approximation to 3D Euclidean distance calculations (10:432). His methid uses no

  10. Blaschko çizgileri dağılımlı lineer liken planus olgusu


    Uçmak, Derya; Yeşilova, Yavuz; Gençoğlu, Metehan


    Lichen planus is an inflammatory disorder that may involve skin and mucous membranes. Linear lichen planus is a rare disorder occurring in approximately 0.2% of patients with lichen planus. We report a case of linear lichen planus on the upper extremity which lesions followed the lines of Blaschko. J Clin Exp Invest 2011; 2 (4): 430-432

  11. Scientific Research Program for Power, Energy, and Thermal Technologies. Task Order 0001: Energy, Power, and Thermal Technologies and Processes Experimental Research. Subtask: Thermal Management of Electromechanical Actuation System for Aircraft Primary Flight Control Surfaces (United States)


    operate on a power- on-demand basis, reducing energy consumption typically required by hydraulic systems to maintain hydraulic pressure. Additionally...6 3.3 Heat Sink ..................................................................................................................7 3.4...26 4.3.1 Electromechanical Actuator ..............................................................26 4.3.2 Hydraulic Press

  12. Establishing Normative Reference Values for Handgrip among Hungarian Youth (United States)

    Saint-Maurice, Pedro F.; Laurson, Kelly R.; Karsai, István; Kaj, Mónika; Csányi, Tamás


    Purpose: The purpose of this study was to examine age- and sex-related variation in handgrip strength and to determine reference values for the Hungarian population. Method: A sample of 1,086 Hungary youth (aged 11-18 years old; 654 boys and 432 girls) completed a handgrip strength assessment using a handheld dynamometer. Quantile regression was…

  13. Prepubertal unilateral gynecomastia and the presence of 47,XXY mosaicism in breast epithelial cells

    DEFF Research Database (Denmark)

    Andersen, Peter Stemann; Petersen, Bodil Laub; Juul, Anders


    , and sclerotherapy with Picibanil (OK-432) was attempted without any detectable effect on size. The mass was later excised. The pathological examination revealed mammary gland tissue suggestive of idiopathic gynecomastia. FISH revealed 47, XXY mosaicism in the abnormal breast epithelial cells, but not in peripheral...

  14. Dollar Summary of Federal Supply Classification and Service Category by Company, FY84, Part 5 (6630-7530). (United States)



  15. Gender Divide and Acceptance of Collaborative Web 2.0 Applications for Learning in Higher Education (United States)

    Huang, Wen-Hao David; Hood, Denice Ward; Yoo, Sun Joo


    Situated in the gender digital divide framework, this survey study investigated the role of computer anxiety in influencing female college students' perceptions toward Web 2.0 applications for learning. Based on 432 college students' "Web 2.0 for learning" perception ratings collected by relevant categories of "Unified Theory of Acceptance and Use…

  16. Construction of an Americn mink Bacterial Artificial Chromosome (BAC) library and sequencing candidate genes important for the fur industry

    DEFF Research Database (Denmark)

    Anistoroaei, Razvan Marian; Hallers, Boudewijn ten; Nefedov, Michael;


    consisting of 18,432 clones spotted in duplicate, have been produced for hybridization screening and are publicly available. Overgo probes derived from expressed sequence tags (ESTs), representing 21 candidate genes for traits important for the mink industry, were used to screen the BAC library...

  17. Experiment list: SRX1388769 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available SRX1388769 ce10 Histone H3K9me3 Adult Young adult NA 3183642,96.9,6.1,432 GSM191965...5: WT 23C G2 rep2 H3K9me3ChIP; Caenorhabditis elegans; ChIP-Seq source_name=Young adult whole animal || geno

  18. Parenting Styles and Health-Related Behavior in Childhood and Early Adolescence: Results of a Longitudinal Study (United States)

    Lohaus, Arnold; Vierhaus, Marc; Ball, Juliane


    This study addresses the development of health-related behavior during childhood and adolescence and the protective influence of an authoritative parenting style. The study is based on two samples followed from Grades 2 through 5 and from Grades 4 through 7. The first sample consisted of 432 second graders with a mean age of 7.9 years at the…

  19. Prepotent response inhibition and interference control in autism spectrum disorders: two meta-analyses

    NARCIS (Netherlands)

    Geurts, H.M.; van den Bergh, S.F.W.M.; Ruzzano, L.


    Search String Advanced > Saved Searches > ARTICLE TOOLS Get PDF (432K) Save to My Profile E-mail Link to this Article Export Citation for this Article Get Citation Alerts Request Permissions More Sharing ServicesShare|Share on citeulikeShare on facebookShare on deliciousShare on www.mendeley.comShar

  20. Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk

    NARCIS (Netherlands)

    Lacko, M.; Voogd, A.C.; Roelofs, H.M.J.; Morsche, R.H.M. te; Ophuis, M.B.; Peters, W.H.M.; Manni, J.J.


    BACKGROUND: Combinations of genetic polymorphisms in biotransformation enzymes might modify the individual risk for head and neck cancer. METHODS: Blood from 432 patients with head and neck cancer and 437 controls was investigated for genetic polymorphisms in 9 different phase I and II biotransforma

  1. 75 FR 70023 - Outer Continental Shelf (OCS), Western and Central Planning Areas, Gulf of Mexico (GOM) Oil and... (United States)


    ... Security Act (Pub. L. 109-432, December 20, 2006) required BOEMRE to offer approximately 5.8 million acres.... Input is requested on additional measures (e.g., technology or water depth limitations) that would..., Houston, Texas 77032, 1 p.m. CST. Thursday, November 18, 2010, Mobile, Alabama, The Battle...

  2. Final Programmatic Environmental Assessment for Base-Wide Military Construction Planning at Kirtland Air Force Base, New Mexico (United States)


    whiptail lizard (Aspidoscelis inornata), short- horned lizard (Phrynosoma douglassi), lesser earless lizard (Holbrookia maculata), bull snake (Pituophis...Peterson Field Guide to Western Birds. Houghton Mifflin Pub: Boston. pp. 432. Reid, F.A. 2006. Mammals of North America . Houghton Mifflin...ASSESSMENT FOR BASE-WIDE MILITARY CONSTRUCTION PLANNING AT KIRTLAND AIR FORCE BASE, NEW MEXICO Introduction : In accordance with the National

  3. Development and validation of a taxonomy of adverse handover events in hospital settings

    DEFF Research Database (Denmark)

    Andersen, Henning Boje; Siemsen, Inger Margrete D.; Petersen, Lene Funck


    -rater reliability and distribution of types of handover failures and causal factors. The taxonomy contains five types of failures and seven types of main causal factors. The taxonomy was validated against 432 adverse handover event descriptions contained in incident reports (stratified random sample from the Danish...

  4. QTL Information Table: 723 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available 5 RM432 pha Jiang, L., Xu, J., Wei, X., Wang, S., Tang, J., Zhai, H., and Wan, J. (2007). The inheritance of early heading in the rice variety USSR5. J Genet Genomics 34, 46-55. ...

  5. Current evidence on the relationship between CYP1B1 polymorphisms and lung cancer risk: a meta-analysis. (United States)

    Xu, Wenhuan; Zhou, Yunhai; Hang, Xiaosheng; Shen, Di


    The association between single-nucleotide polymorphisms (SNPs) of the CYP1B1 gene and lung cancer risk is still ambiguous. In this meta analysis, we assessed 10 case-control studies included 7,067 cases and 9,374 controls of the association between CYP1B1 SNPs of Leu432Val (rs1056836, 432C>G), Asn453Ser (rs1800440, 453A>G), Ala119Ser (rs1056827, 119G>T), Arg48Gly (rs10012, 48C>G) and the risk of lung cancer. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of association between the polymorphism and lung cancer risk under codominant model, dominant model and additive model respectively. Although there were limitations, this meta analysis indicated that individuals with 432GG genotype had a 39.7% higher risk of having lung cancer than those with the 432CC genotype, and individuals with the 432G allele had a 26.3% increased risk as well. An increased risk of lung cancer of 2.13 fold was observed in individuals with 119TT genotype. For Arg48Gly, individuals with 48GG genotype had a significantly increased risk of lung cancer compared with individuals with 48CC (OR 3.859; 95% CI 2.536-5.87). Elevated risk of lung cancer were observed in dominant model (OR 2.115; 95% CI 1.653-2.705) as well. The risk of lung cancer was elevated as the frequency of G allele increased in additive model (P = 0.000). For individuals with the polymorphism at codon 453, no evidence of such association was observed. Furthermore, a possible association between the CYP1B1 polymorphism at codon 432 and the lung cancer could be detected in individuals of Caucasian origin, while a negative association was suggested in Asians and African-Americans. An increased lung cancer risk was also found in women with polymorphism at codon 453. These results are supportive for the hypothesis that the CYP1B1 432GG, 119TT and 48GG genotypes are low-penetrance risk factors for developing lung cancer, and further studies are needed to validate these associations.

  6. Association between gene polymorphism of CYP1B1 and susceptibility to ovarian cancer%CYP1B1基因多态性与卵巢癌易感性的研究

    Institute of Scientific and Technical Information of China (English)

    朱壮彦; 糜若然; 刘静



  7. Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration

    Institute of Scientific and Technical Information of China (English)

    Leandros Lazaros; Ioannis Georgiou; Nectaria Xita; Elissavet Hatzi; Apostolos Kaponis; Georgios Makrydimas; Atsushi Takenaka; Nikolaos Sofikitis; Theodoros Stefos; Konstantinos Zikopoulos


    Choline is a crucial factor in the regulation of sperm membrane structure and fluidity,and this nutrient plays an important role in the maturation and fertilizing capacity of spermatozoa.Transcripts of phosphatidylethanolamine N-methyltransferase (PEMT) and choline dehydrogenase (CHDH),two basic enzymes of choline metabolism,have been observed in the human testis,demonstrating their gene expression in this tissue.In the present study,we explored the contribution of the PEMTand CHDHgene variants to sperm parameters.Two hundred oligospermic and 250 normozoospermic men were recruited.DNA was extracted from the spermatozoa,and the PEMT -774G>C and CHDH +432G>T polymorphisms were genotyped.The genotype distribution of the PEMT -774G>C polymorphism did not differ between oligospermic and normozoospermic men.In contrast,in the case of the CHDH +432G>T polymorphism,oligospermic men presented the CHDH432G/G genotype more frequently than normozoospermic men (62% vs.42%,P<0.001).The PEMT774G/G genotype was associated with a higher sperm concentration compared to the PEMT774G/C and 774C/C genotypes in oligospermic men (12.5±5.6×106 spermatozoa ml-1 vs.8.3±5.2×106 spermatozoa ml-1,P<0.002) and normozoospermic men (81.5±55.6×106 vs.68.1±44.5× 106 spermatozoa ml-1,P<0.006).In addition,the CHDH432G/G genotype was associated with higher sperm concentration compared to CHDH432G/T and 432T/T genotypes in oligospermic (11.8± 5.1 × 106 VS.7.8±5.3 × 106spermatozoa ml-1,P<0.003)and normozoospermic men(98.6±62.2×106vs.58.8±33.6×106 spermatozoa ml-1,p<0.001).In our series,the PEMT-774G>C and CHDH +432G>T polymorphisms were associated with sperm concentration.This finding suggests a possible influence of these genes on sperm quality.

  8. Cytochrome P450 1B1 gene polymorphisms as predictors of anticancer drug activity: studies with in vitro models. (United States)

    Laroche-Clary, Audrey; Le Morvan, Valérie; Yamori, Takao; Robert, Jacques


    Cytochrome P450 1B1 (CYP1B1) is found in tumor tissue and is suspected to play a role in oncogenesis and drug resistance. CYP1B1 gene polymorphisms have been associated with the risk of developing lung and other cancers. They may be associated with tumor response to anticancer drugs. We have determined 4 frequent nonsynonymous gene polymorphisms of CYP1B1 in the human tumor cell lines panels of the National Cancer Institute (NCI) and the Japanese Foundation for Cancer Research (JFCR): rs10012 (R48G), rs1056827 (A119S), rs1056836 (L432V), and rs1800440 (N453S). Numerous anticancer drugs have been tested against these panels that offer the opportunity to detect associations between gene polymorphisms and drug sensitivity. CYP1B1 single nucleotide polymorphisms were in marked linkage disequilibrium. The L432V allelic variants were significantly associated with reduced sensitivity to DNA-interacting anticancer agents, alkylators, camptothecins, topoisomerase II inhibitors, and some antimetabolites. For instance, in the NCI panel, cell lines homozygous for the V432 allele were globally 2-fold resistant to alkylating agents (P = 5 × 10(-10)) and 4.5-fold to camptothecins (P = 6.6 × 10(-9)) than cell lines homozygous for the L432 allele. Similar features were exhibited by the JFCR panel. Cell lines homozygous for the V432 allele were globally less sensitive to DNA-interfering drugs than cell lines having at least 1 common allele. There was no significant association between mRNA expression of CYP1B1 and CYP1B1 genotype, and no significant association between CYP1B1 mRNA expression and drug cytotoxicity. These observations open the way to clinical studies exploring the role of CYP1B1 gene polymorphisms for predicting tumor sensitivity to chemotherapy.

  9. Association between CYP1A2 and CYP1B1 polymorphisms and colorectal cancer risk: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Xiao-Feng He

    Full Text Available BACKGROUND: The previous published data on the association between CYP1A2*F (rs762551, CYP1B1 Leu432Val (rs1056836, Asn453Ser (rs180040, and Arg48Gly (rs10012 polymorphisms and colorectal cancer risk remained controversial. METHODOLOGY/PRINCIPAL FINDINGS: The purpose of this study is to evaluate the role of CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly genotypes in colorectal cancer susceptibility. We performed a meta-analysis on all the eligible studies that provided 5,817 cases and 6,544 controls for CYP1A2*F (from 13 studies, 9219 cases and 10406 controls for CYP1B1 Leu432Val (from 12 studies, 6840 cases and 7761 controls for CYP1B1 Asn453Ser (from 8 studies, and 4302 cases and 4791 controls for CYP1B1Arg48Gly (from 6 studies. Overall, no significant association was found between CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly and colorectal cancer risk when all the eligible studies were pooled into the meta-analysis. And in the subgroup by ethnicity and source of controls, no evidence of significant association was observed in any subgroup analysis. CONCLUSIONS/SIGNIFICANCE: In summary, this meta-analysis indicates that CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly polymorphisms do not support an association with colorectal cancer, and further studies are needed to investigate the association. In addition, our work also points out the importance of new studies for CYP1A2*F polymorphism in Asians, because high heterogeneity was found (dominant model: I(2  = 81.3%; heterozygote model: I(2  = 79.0.

  10. Toxicity studies for indigenous Bacillus thuringiensis isolates from Malang city, East Java on Aedes aegypti larvae

    Institute of Scientific and Technical Information of China (English)

    Zulfaidah Penata Gama; Nobukazu Nakagoshi; Suharjono; Faridah Setyowati


    Objective: To investigate the toxicity of indigenous Bacillus thuringiensis (B. thuringiensis) isolates from Malang City for controlling Aedes aegypti (Ae. aegypti) larvae. Methods: Soil samples were taken from Purwantoro and Sawojajar sub-districts. Bacterial isolation was performed using B. thuringiensis selective media. Phenotypic characteristics of the isolates were obtained with the simple matching method. The growth and prevalence of spores were determined by the Total Plate Count method, and toxicity tests were also performed on the third instar larval stage of Ae. aegypti. The percentage of larval mortality was analysed using probit regression. The LC50 was analysed by ANOVA, and the Tukey HSD interval was 95%. Results:Among the 33 selected bacterial isolates, six were obtained (PWR4-31, PWR4-32, SWJ4-2b, SWJ4-4b, SWJ-4k and SWJ5-1) that had a similar phenotype to reference B. thuringiensis. Based on the dendrogram, all of the bacterial isolates were 71%similar. Three isolates that had a higher prevalence of reference B. thuringiensis were PWR4-32, SWJ4-4b and SW5-1, of which the spore prevalence was 52.44%, 23.59%, 34.46%, respectively. These three indigenous isolates from Malang City successfully killed Ae. aegypti larvae. The PWR4-32 isolates were the most effective at killing the larvae. Conclusions:Six indigenous B. thuringiensis isolates among the 33 bacterial isolates found in the Sawojajar and Purwantoro sub-districts were toxic to the third instar larvae of Ae. aegypti. The PWR4-32 isolates were identical to the reference B. thuringiensis and had 88%phenotype similarity. The PWR4-32 isolates had the highest spore prevalence (52.44%), and the early stationary phase occurred at 36 h. The PWR4-32 isolates were the most effective at killing Ae. aegypti larvae (LC50-72 h=2.3í108 cells/mL).

  11. Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase

    Energy Technology Data Exchange (ETDEWEB)

    Pattanayek, Rekha; Mori, Tetsuya; Xu, Yao; Pattanayek, Sabuj; Johnson, Carl H.; Egli, Martin; (Vanderbilt)


    The circadian clock of the cyanobacterium Synechococcus elongatus can be reconstituted in vitro by three proteins, KaiA, KaiB and KaiC. Homo-hexameric KaiC displays kinase, phosphatase and ATPase activities; KaiA enhances KaiC phosphorylation and KaiB antagonizes KaiA. Phosphorylation and dephosphorylation of the two known sites in the C-terminal half of KaiC subunits, T432 and S431, follow a strict order (TS {yields} pTS {yields} pTpS {yields} TpS {yields} TS) over the daily cycle, the origin of which is not understood. To address this void and to analyze the roles of KaiC active site residues, in particular T426, we determined structures of single and double P-site mutants of S. elongatus KaiC. The conformations of the loop region harboring P-site residues T432 and S431 in the crystal structures of six KaiC mutant proteins exhibit subtle differences that result in various distances between Thr (or Ala/Asn/Glu) and Ser (or Ala/Asp) residues and the ATP {gamma}-phosphate. T432 is phosphorylated first because it lies consistently closer to P{gamma}. The structures of the S431A and T432E/S431A mutants reveal phosphorylation at T426. The environments of the latter residue in the structures and functional data for T426 mutants in vitro and in vivo imply a role in dephosphorylation. We provide evidence for a third phosphorylation site in KaiC at T426. T426 and S431 are closely spaced and a KaiC subunit cannot carry phosphates at both sites simultaneously. Fewer subunits are phosphorylated at T426 in the two KaiC mutants compared to phosphorylated T432 and/or S431 residues in the structures of wt and other mutant KaiCs, suggesting that T426 phosphorylation may be labile. The structures combined with functional data for a host of KaiC mutant proteins help rationalize why S431 trails T432 in the loss of its phosphate and shed light on the mechanisms of the KaiC kinase, ATPase and phosphatase activities.

  12. No more than conjectures: Popper and the ethics of scientific enterprise. (United States)

    Doria, Nilson Guimarães


    Karl Popper dealt with both problems Yurevich (Integrative Psychological and Behavioral Science, 43(2), 2009, doi: 10.1007/s12124-008-9082-7 ) deals: the crisis in Psychology and in the discourse about the nature of science. Although he failed to provide a complete response for both problems, his proposals can yet be fruitful to the reflection on these matters in the context of the present discussion. He offers some tentative answers to what could be considered a healthy epistemic activity, something Yurevich does not provide. More interestingly, some of the Popper proposals seem to fit, and in some extent correct, the quest for "collaborative work" proposed by Zittoun et al. (Integrative Psychological and Behavioral Science, 43(2), 2009, doi: 10.1007/s12124-008-9082-7 ) as a way of transforming crisis in development.

  13. Acute Kidney Injury Classification in Neuro-ICU Patient Group

    Directory of Open Access Journals (Sweden)

    Canan Akıncı


    Full Text Available Objective: To investigate the role of acute kidney injury (AKI classification system for kidney injury outcome in neuro-Intensive care unit (ICU patients. Material and Method: Total 432 patients who admitted to ICU between 2005 and 2009 evaluated in this study. All patients’ AKI stage, Acute Physiology and Chronic Health Evaluation (APACHE-II, Sequential Organ Failure Assessment Score (SOFA, Glasgow Coma Score (GCS, Glasgow Outcome Score (GOS, mortality rate, length of ICU stay, need for intubation, and mechanical ventilation were recorded. Results: AKI was found in 24 of all 432 patents’ (5.5%. We found that, patients with AKI had higher APHACE-II score, SOFA score and mortality rates; longer ICU stay, duration of mechanical ventilation and intubation and lower GCS and GOS than without AKI group. Conclusion: Length of ICU stay and mortality rate were higher in AKI positive group.

  14. Powder metallurgy processing of high strength turbine disk alloys (United States)

    Evans, D. J.


    Using vacuum-atomized AF2-1DA and Mar-M432 powders, full-scale gas turbine engine disks were fabricated by hot isostatically pressing (HIP) billets which were then isothermally forged using the Pratt & Whitney Aircraft GATORIZING forging process. While a sound forging was produced in the AF2-1DA, a container leak had occurred in the Mar-M432 billet during HIP. This resulted in billet cracking during forging. In-process control procedures were developed to identify such leaks. The AF2-1DA forging was heat treated and metallographic and mechanical property evaluation was performed. Mechanical properties exceeded those of Astroloy, one of the highest temperature capability turbine disk alloys presently used.

  15. Simultaneous circulation of all four dengue serotypes in Manaus, State of Amazonas, Brazil in 2011

    Directory of Open Access Journals (Sweden)

    Michele de Souza Bastos


    Full Text Available INTRODUCTION: Manaus, the capital city of the state of Amazon with nearly 2 million inhabitants, is located in the middle of the Amazon rain forest and has suffered dengue outbreaks since 1998. METHODS: In this study, blood samples were investigated using reverse transcriptase-polymerase chain reaction (RT-PCR, aimed at identifying dengue virus serotypes. RESULTS: Acute phase sera from 432 patients were tested for the presence of dengue virus. Out of the 432 patients, 137 (31.3% were found to be positive. All the four dengue virus serotypes were observed. CONCLUSIONS: The simultaneous circulation of the four dengue serotypes is described for the first time in Manaus and in Brazil.

  16. AcEST: BP912033 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000012_C06 432 Adiantum capillus-veneris mRNA. clone: YMU001_000012_C06. BP9120...33 CL389Contig1 Show BP912033 Clone id YMU001_000012_C06 Library YMU01 Length 432 Definition Adiantum cap...illus-veneris mRNA. clone: YMU001_000012_C06. Accession BP912033 Tissue type prothallium Developmental stage...), Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Res. 25:3389-3402. Query= BP9120... search programs, Nucleic Acids Res. 25:3389-3402. Query= BP912033|Adiantum capillus-veneris mRNA, clone: YM

  17. Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate

    Directory of Open Access Journals (Sweden)

    Eduardo GONÇALVES


    Full Text Available The aim of this study was to determine the frequency of leukemia in parents of patients with nonsyndromic cleft lip and/or cleft palate (NSCL/P. This case-control study evaluated first-degree family members of 358 patients with NSCL/P and 1,432 subjects without craniofacial alterations or syndromes. Statistical analysis was carried out using Fisher’s test. From the 358 subjects with NSCL/P, 3 first-degree parents had history of leukemia, while 2 out of 1,432 subjects from the unaffected group had a family history of leukemia. The frequency of positive family history of leukemia was not significantly increased in first-degree relatives of patients with NSCL/P.

  18. Research and Development of Methods for Estimating Physicochemical Properties of Organic Compounds of Environmental Concern. Part 1. (United States)


    Inc 4-32 i ____________________________ 42. Stevenson , P.M., "Organic Matter Reactions Involving Pesticides in Soil," in Bound and Conjugated compounds includes such naturally occur- ring substances as humus and lignin, as well as such anthropogenic substances as some of the...microbiology. Wood, E.J.F. [170] - Textbook on marine and estuarine micro- biology. Rodina, R.G. (138] - Textbook on aquatic microbiology. Stevenson , L.H. and

  19. Status and performance of the CDF Run II silicon detector

    Energy Technology Data Exchange (ETDEWEB)

    Maki, Tuula; /Helsinki Inst. of Phys.


    The CDF silicon detector is one of the largest silicon detectors in operation. It has a total of 722,432 electronic channels, and it covers a sensor surface area of 6 m{sup 2}. The detector has been operating reliably for five years, and it has recorded 1.5 fb{sup -1} of data. This article discusses experiences of operating such a large, complex system as well as the longevity of the detector.

  20. Dental caries and dental fluorosis in 7-12-year-old schoolchildren in Catalão, Goiás, Brazil


    Bardal, Priscila Ariede Petinuci; OLYMPIO, Kelly Polido Kaneshiro; Buzalaf, Marília Afonso Rabelo; BASTOS, José Roberto Magalhães


    INTRODUCTION: Over the last two decades, the prevalence of dental caries in children has decreased and the prevalence of dental fluorosis has increased. Knowledge on the epidemiologic conditions of a population is fundamental for the planning of health programs. OBJECTIVES: To determine the prevalence of dental caries and dental fluorosis among schoolchildren, in Catalão, Goiás, Brazil. METHODS: A random sample of 432 schoolchildren aged 7-12-years old was obtained. WHO (1997) criteria for de...

  1. Effects of Saint John’s Wort and Vitamin E on Breast Cancer Chemotherapeutic Agents (United States)


    oxidative stress in human cells. Biochem . J. 348:425-432. 23 LEGENDS TO FIGURES 1. Nadir WBC counts measured 4 days after treatment of rats with docetaxel...fibrosis, and cisplatin- induced neuropathy and nephrotoxicity , antioxidants have been used to reduce or prevent these side effects (24 and reviewed in...drop in white count after cyclophosphamide in rats . Neither vitamin E nor St. John’s wort supplementation modified rodent hepatic mitochondrial DNA

  2. Medical Research Publications: A Bibliography of Walter Reed Army Medical Center Staff, 1986-1992. Volume 2 (United States)


    Reynolds PC, Hahn MB. Early diagnosis of a spinal epidural abscess . RegAnesth 1991 Jan;16(1):57-8. Surgery. Anesthesia. 1407. Rich GF, Lubanski RE... epidural abscess . Reg Anesth 1991 Jan;16(1):57-8. Surgery. Anesthesia. 513 433. Rich GF, Lubanski RE, McLoughlin TM. Differences between aortic and radial...somatosensory evoked potentials. Anesth Analg 1991 Nov;73(5):653-6. Surgery. Anesthesia. 432. Reynolds PC, Hahn MB. Early diagnosis of a spinal

  3. The Relationship of PTSD and Communication with Intimate Partners in a Sample of Vietnam Veterans (United States)


    traumatic stress disorder. Clinical Psychology Review , 9, 243-257. Litz, B. T., Schlenger, W. E., Weathers, F. W., Caddell, J. M., Fairbank, J. A...intimate relationships: From description to theory-driven research and intervention development. Clinical Psychology Review . Montemayor, R., Eberly, M... Psychology Review , 12, 417-432. Litz, B. T., & Keane, T. M. (1989). Information processing in anxiety disorders: Application to the understanding of post

  4. stand a chance后可以跟to do sth.吗?

    Institute of Scientific and Technical Information of China (English)



    [432]2000年12月大学英语四级考试作文How to Succeed in a Job Interview的范文中(见《大学英语四六级考试全真题集详解》,王怀刚等主编,航空工业出版社,2001.8.P.163),有以下一句。

  5. Analysis of Archaeological, Geological and Historical Artifacts and Documents Pertaining to the Midden Excavation at ’Woodville’ - Unit 4, James G. Fulton, Flood Protection Project, Chartiers Creek, Pennsylvania, (United States)


    Ferguson 1938:25; Felton 1932:15; Downes 1969:183). Although John Neville reappeared in the Pittsburgh area in September of 1775, there are indications...Represented: 2 shakers, salt and pepper : base diameter is 3.5 cm. Comments: N/A. Pattern: 358 Paste: Porcelain. No. of Specimens: 11 Figure: 358. Decorative...personal items. Tableware is futher seen in a set of six butterpats (432), salt and pepper shakers (237), and several serving dishes and platters

  6. Sequential Quadratic Programming Algorithms for Optimization (United States)


    order KKT point for NLP, (4.3.2) comploting 1e proof. U Descent properties As (,Xplaiid in (’iapter 3, we need to impose some condition on the...For the step along d, note that a < nOing + 3 szH + i3. ninA A a K f~Iz,;nd and from Id1 _< ,,, we must have that for some /3 ,np, 11P11 < dn"p. 5.2

  7. The long range distributed fiber raman photon temperature sensor

    Institute of Scientific and Technical Information of China (English)


    A 31 km long range distributed optical fiber Raman photon temperature sensor (DOFRPTS) system have been developed based on temperature effect of the amplified spontaneous Raman scattering in fiber, and using fiber laser as a pumped source. The results show that temperature measuring uncertainty is ±2 ℃, temperature resolution is 0.1 ℃, measurement time is 432 s, spatial resolution is less than 4 m.

  8. Relations Among Student Attention Behaviors, Teacher Practices, and Beginning Word Reading Skill



    The role of student attention for predicting kindergarten word reading was investigated among 432 students. Using SWAN behavior rating scores, we conducted an exploratory factor analysis, which yielded three distinct factors that reflected selective attention. In this study, we focused on the role of one of these factors, which we labeled attention-memory behaviors, for predicting reading performance. Teacher ratings of attention predicted word reading above and beyond the contribution of pho...

  9. U.S. Army Corps of Engineers Recreation Study. A Plan Prepared for the Assistant Secretary of the Army (Civil Works). Volume 2. Appendices (United States)


    of new recreation facilities could impact the resource base as presently undeveloped buffer or natural areas would be converted to intensively...volunteers and remove restrictions 50.0 16.6 IVF Reduce the frequency of in-house inspections 45.9 10.8 IVG Monitor facility use level 43.2 0.0 IVS...IVS EFFY aggregates options that involve minor efficiency-related actions. Includes responses to the following questions: IVC, IVF , IVH, IVL, IVM

  10. Thraustochytrid protists degrade hydrocarbons

    Digital Repository Service at National Institute of Oceanography (India)

    Raikar, M.T.; Raghukumar, S.; Vani, V.; David, J.J.; Chandramohan, D.

    Rev, 54 (1990) 305-315. 12 Fedorak P M & Westlake D W S, Microbial degradation of aromatics and saturates in Prudhoe Bay crude oil as determined by glass capillary gas chromatography, Can J Microbiol, (1981) 432-443. 13 Atlas R M, Microbial... degradation of petroleum hydrocarbons: An environmental perspective, Microbiol Rev, 45 (1981) 180-209. 14 Atlas R M, Microbial hydrocarbon degradation- Bioremediation of oil spills, J Chem Tech Biotechnol, 52 (1991) 149-156 15 Venkateswaran K, Iwabuchi T...

  11. Algebraic Techniques in Systolic Array Design. (United States)


    a heuristic algorithm which finds graphs I with small diameter, and implemented it on a computer. The program is written in the C-language. We have...problem consist of the construction of a heuristic algorithm (see Section 4.2.2), and some specific constructions derived from 17 group theory (see...the graphs rl are usually quite large, the time spent computing invariants is of primary importance. 4.3.2 A Heuristic Algorithm . A "hill-climbing

  12. Combat Veterans with PTSD after Mild TBI Exhibit Greater ERPs from Posterior-medial Cortical Areas While Appraising Facial Features (United States)


    within the past 30 days; (2) life- time history of bipolar disorder , attention deficit hyperactivity disorder , or psychotic disorder ; or (3) acute medical...Arbisi, P.A., Thuras, P., 2011. Longitudinal effects of mild traumatic brain injury and posttraumatic stress disorder comorbidity on postdeployment...The effects of temporal unpredictability in anticipation of negative events in combat veterans with PTSD. J. Affect. Disord . 146, 426–432. Simmons, A.N

  13. Antidepressant drugs: evaluation of price variation

    Directory of Open Access Journals (Sweden)

    Bhumika Jayantilal Patel


    Conclusion: Price variation was wide for antidepressant drugs. Generic drug prescribing can decrease the expenditure of patient on the drug. Prescribers should be provided updated knowledge of the cost of different drugs. Modifications in pharmaceutical policy are required, and prices of the drug should be controlled in effective way for all the drugs. [Int J Basic Clin Pharmacol 2015; 4(3.000: 432-437

  14. Individual, Family, and Culture Level Contributions to Child Physical Abuse and Neglect: A Longitudinal Study in Nine Countries


    Lansford, Jennifer E.; Godwin, Jennifer; Uribe Tirado, Liliana Maria; Zelli, Arnaldo; Al-Hassan, Suha M.; Bacchini, Dario; Bombi, Anna Silvia; Bornstein, Marc H.; Chang, Lei; Deater-Deckard, Kirby; Di Giunta, Laura; Dodge, Kenneth A.; Malone, Patrick S.; Oburu, Paul; Pastorelli, Concetta


    This study advances understanding of predictors of child abuse and neglect at multiple levels of influence. Mothers, fathers, and children (N = 1,432 families, M age of children = 8.29 years) were interviewed annually in three waves in 13 cultural groups in nine countries (China, Colombia, Italy, Jordan, Kenya, Philippines, Sweden, Thailand, and the United States). Multilevel models were estimated to examine predictors of (a) within-family differences across the three time points, (b) between...

  15. 光度、色度计量与装置

    Institute of Scientific and Technical Information of China (English)


    O432.3 99031415基于神经网络的数字式CRT色度控制方法=DigitalCRT color control by artificial neural networks[刊,中]/廖宁放,石俊生,余鸿飞,王月芳(云南师范大学.云南,昆明(650092)),高稚允(北京理工大学.北京(100081))//兵工学报.—1998,19(1).-46-50

  16. High-spin states in the sup 9 sup 7 Tc nucleus

    CERN Document Server

    Bucurescu, D; Cata-Danil, I; Ivascu, M; Marginean, N; Rusu, C; Stroe, L; Ur, C A; Gadea, A


    High-spin states in the sup 9 sup 7 Tc nucleus have been studied by in-beam gamma-ray spectroscopy with the reaction sup 8 sup 2 Se( sup 1 sup 9 F,4n gamma) at 68 MeV incident energy. Excited states have been observed up to about 8 MeV excitation and spin 43/2 Planck constant. The observed level scheme is compared with results of shell model calculations. (orig.)

  17. High-spin states in the {sup 97}Tc nucleus

    Energy Technology Data Exchange (ETDEWEB)

    Bucurescu, D.; Cata-Danil, G.; Cata-Danil, I.; Ivascu, M.; Marginean, N.; Rusu, C.; Stroe, L.; Ur, C.A. [National Institute of Physics and Nuclear Engineering, P.O. Box MG-6, Bucharest 76900 (Romania); Gadea, A. [INFN, Laboratori Nazionali di Legnaro, Legnaro (Italy)


    High-spin states in the {sup 97}Tc nucleus have been studied by in-beam {gamma}-ray spectroscopy with the reaction {sup 82}Se({sup 19}F,4n{gamma}) at 68 MeV incident energy. Excited states have been observed up to about 8 MeV excitation and spin 43/2{Dirac_h}. The observed level scheme is compared with results of shell model calculations. (orig.)

  18. Prevalence of Overweight/Obesity and Its Associated Factors among University Students from 22 Countries


    Karl Peltzer; Supa Pengpid; T Alafia Samuels; Neslihan Keser Özcan; Carolina Mantilla; Onja H. Rahamefy; Mee Lian Wong; Alexander Gasparishvili


    Obesity among young people increases lifetime cardiovascular risk. This study assesses the prevalence of overweight/obesity and its associated factors among a random sample of university students from 22 universities in 22 low, middle income and emerging economy countries. This cross-sectional survey comprised of a self-administered questionnaire and collected anthropometric measurements. The study population was 6773 (43.2%) males and 8913 (56.8%) females, aged 16 to 30 years (mean 20.8 year...

  19. Contingent Weighting in Judgment and Choice. (United States)


    Review, 94, 236-254. Grether, D. M., & Plott, C. R. (1979). Economic theory of choice and the preference rever- sal phenomenon. American Economic Review , 69...805-824. Loomes, G., & Sugden, R. (1983). A rationale for preference reversal. American Economic Review , 73, 428-432. Payne, J. W. (1982). Contingent...Lichtenstein, S. (1983). Preference reversals: A broader perspective. American Economic Review , 73, 596-605. Slovic, P., Lichtenstein, S

  20. Fiber Optic Based Signal Processing (United States)


    Bundle * ?* * FIR Phase Mod. Tap * * FIR Recirc. Delay L ?* IIR Non Rec. ID Latt * FIR Rec. 1D Latt * * * * IIR Mixed lD Latt IIR Non Rec. 2D Latt FIR Rec...Appl. No.: 326,657 cslFlw.- Appl. Pby Lert. vol. 43(2). p. 149.,1933. 12.2] Fik& td 21, 198 P E.-a iu -Wiliamn L S~kes Az~naAr Ezw ~unrr-obn Ngo [51) ImL

  1. Impact d'un programme d'éducation thérapeutique du patient à l'activité physique chez des patients en phase subaiguë d'accident vasculaire cérébral


    Kammoun, Benjamin


    In France, we estimate at 150,000 the number of cerebral vascular accident per year. With a cost of 8.3 billion euros, it has become a public health issue. The expenses are, among others, related to legacy, as 43.2% leave hospital being physically dependent.These effects will aftereffect will cause limitations, causing a vicious cycle of inactivity and deconditioning bringing. To fight against this deconditioning, it seems appropriate to follow the recommendations of learned societies in term...

  2. Implementing the LifeSkills Training drug prevention program: factors related to implementation fidelity


    Fagan Abigail A; Mihalic Sharon F; Argamaso Susanne


    Abstract Background Widespread replication of effective prevention programs is unlikely to affect the incidence of adolescent delinquency, violent crime, and substance use until the quality of implementation of these programs by community-based organizations can be assured. Methods This paper presents the results of a process evaluation employing qualitative and quantitative methods to assess the extent to which 432 schools in 105 sites implemented the LifeSkills Training (LST) drug preventio...

  3. Targeting the Prostate Cancer Microenvironment to Improve Therapeutic Outcomes (United States)


    Sun, Ph.D. CONTRACTING ORGANIZATION: Seattle Institute for Biomedical and Clinical Research Seattle, WA 98108-1532 REPORT DATE: August 2015 TYPE OF...NUMBERSeattle Institute for Biomedical and Clinical Research 1660 S Columbian Way, S-151F Seattle, WA 98108-1532 9. SPONSORING / MONITORING AGENCY NAME(S) AND...Phosphatidylinositol-3-Kinase/Akt Regulates Bleomycin-Induced Fibroblast Proliferation and Collagen Production. Am J Respir Cell Mol Biol. 42: 432

  4. Development of an Accelerated Hydrogen Embrittlement Test for Manganese Phosphated Steels (United States)


    Testing Systems) and lot (HT/ HTP ) were used. See Appendix B for the certifications for lots HT/ HTP . Note: lot HTP is...long as 432 hrs., and testing after furnace bakeout. The majority of testing was performed on the same lot of material (RSL Lot HT/ HTP ) and coated by...slower ISL tests were performed. Figure 14. ISL  test  specimen RSL  HTP  #089  tested

  5. Missile Defense: Opportunity to Refocus on Strengthening Acquisition Management (United States)


    defense operations, see the battle develop, and manage networked sensors and weapon systems. Ground-based Midcourse Defense (GMD) A ground-based...However, this retest also failed in December 2010 due to the effects of vibration on the kill vehicle’s guidance system. As a result of these...the life cycle— research and development, procurement, military construction, GAO-13-432. 15Pub. L. No. 110-181, § 223(g), repealed by Pub. L. No

  6. 辐射测量及仪器

    Institute of Scientific and Technical Information of China (English)


    O432.1 98031425雪面辐射温度预测模型=A model to predict theradiative temperature of snow surface[刊,中]/张建奇,方小平,张海兴,杨威(西安电子科技大学物理系.陕西,西安(710071)),朱长纯(西安交通大学电信

  7. Synthesis and Characterization of Liquid Crystalline Epoxy Resins (United States)


    4.3.2 Sample Preparation The epoxy monomer was placed in a beaker and heated in an oil bath. Once the monomer was completely melted, the curing...83-91. [9] Carfagna C, Acierno D, Di Palma V, Amendola E, and Giamberini M. Macromolecular Chemistry and Physics 2000;201(18):2631-2638. 89...preheated to 150 ºC before the tube was inserted. Unoriented LCERs samples were prepared in the same manner, but were cured in an oil bath for

  8. Population Structure Analysis of Bull Genomes of European and Western Ancestry


    Neo Christopher Chung; Joanna Szyda; Magdalena Frąszczak


    Since domestication, population bottlenecks, breed formation, and selective breeding have radically shaped the genealogy and genetics of Bos taurus. In turn, characterization of population structure among diverse bull (males of Bos taurus) genomes enables detailed assessment of genetic resources and origins. By analyzing 432 unrelated bull genomes from 13 breeds and 16 countries, we demonstrate genetic diversity and structural complexity among the European/Western cattle population. Important...

  9. 《认知语言学:内在动力与跨学科互动》介绍%Francisco J. Ruiz de Mendoza Ibá(n)ez & M. Sandra Pe(n)a Cervel(eds.).2005.Cognitive Linguistics: Internal Dynamics and Interdisciplinary Interaction

    Institute of Scientific and Technical Information of China (English)



    1.内容概览《认知语言学:内在动力与跨学科互动》一书由Francisco J.Ruiz de Mendoza Ibánez和M.Sandra Pena Cervel编辑,2005年由Moutonde Gruyter出版公司出版。全书432页,11篇论文,分为四个部分。

  10. Inhibition of Matriptase Activity Results in Decreased Intestinal Epithelial Monolayer Integrity In Vitro.

    Directory of Open Access Journals (Sweden)

    E Pászti-Gere

    Full Text Available Barrier dysfunction in inflammatory bowel diseases implies enhanced paracellular flux and lowered transepithelial electrical resistance (TER causing effective invasion of enteropathogens or altered intestinal absorption of toxins and drug compounds. To elucidate the role of matriptase-driven cell surface proteolysis in the maintenance of intestinal barrier function, the 3-amidinophenylalanine-derived matriptase inhibitor, MI-432 was used on porcine IPEC-J2 cell monolayer. Studies with two fluorescent probes revealed that short (2 h treatment with MI-432 caused an altered distribution of oxidative species between intracellular and extracellular spaces in IPEC-J2 cells. This perturbation was partially compensated when administration of inhibitor continued for up to 48 h. Significant decrease in TER between apical and basolateral compartments of MI-432-treated IPEC-J2 cell monolayers proved that matriptase is one of the key effectors in the maintenance of barrier integrity. Changes in staining pattern of matriptase and in localization of the junctional protein occludin were observed suggesting that inhibition of matriptase by MI-432 can also exert an effect on paracellular gate opening via modulation of tight junctional protein assembly. This study confirms that non-tumorigenic IPEC-J2 cells can be used as an appropriate small intestinal model for the in vitro characterization of matriptase-related effects on intestinal epithelium. These findings demonstrate indirectly that matriptase plays a pivotal role in the development of barrier integrity; thus matriptase dysfunction can facilitate the occurence of leaky gut syndrome observed in intestinal inflammatory diseases.

  11. Image Understanding Workshop. Proceedings of a Workshop Held in Los Angeles, California on 23-25 February 1987. Volume 1 (United States)


    432 "The CMU Navigational Architecture", Anthony Stntz, Yoshimasa Goto; Carnegie- Mellon University ............................ 440...hour on a SUN-3. References (1] Annaratone, M., Bitz, F., Deutch, J., Harney, L., Kung, 6. The Calibrated Imaging Laboratory H. T., Maulik, P., Ribas ...knowledge-based fra.iework within RIBA to achieve the 12. E. Davis, Representing and Acquiring Geographic required performance which is beyond what

  12. PetroChina and Sinopec Raises Oil Ex-refinery Prices

    Institute of Scientific and Technical Information of China (English)


    @@ Sinopec and PetroChina have raised ex-refinery prices for gasoline and diesel to boost sagging margins as it faces soaring crude prices. The Chinese refiners increased 90-octane gasoline price by 100 yuan (US$12) a ton to about 3,580 yuan (US$432) a ton, and that of diesel by 40 yuan (US$4.80) a ton to 3,602 yuan (US$435),effective September 17.

  13. Data of evolutionary structure change: 1TUXA-2Q8XB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available line> ATOM 800 CA LEU A 104 5.685 -6.148 30.982 1.00 6.75 C -map> ....81 THR CA 3.86 LEU CA -map> VAL CA 350 -map> LEU VAL ASP ARG SER V...47 3.82 VAL CA 3.81 LEU CA -map> ATOM 1101 CA GLN A 141 -0.646 -15.830 21.432 1.00 14.03 C -map>

  14. Profile of American Youth: Demographic Influences on ASVAB (Armed Services Vocational Aptitude Battery) Test Performance (United States)


    Jeficient educati-nal achievement, there was no con- sensus on the factors contributing to school failure , how they were mediated by social class and...assessed pri- marily in terms of school failure rate. School failure was defined as either having to repeat grades or placement in clauses for slow...learners. The school failure observed for the adopted children was 4/32, for their half-siblings 16/32, for children of unskilled workers in general 16.5

  15. Domain Modeling: NP_115754.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_115754.2 chr8 Crystal structure of an 8 repeat consensus TPR superhelix (trigona...l crystal form) p2hyza_ chr8/NP_115754.2/NP_115754.2_apo_4-171.pdb p2fo7a_ chr8/NP_115754.2/NP_115754.2_holo_4-171.pdb psi-blast 381K,382F,383K,431S,432G,443H _CD 1 ...

  16. Prevalence and Characteristics of Pregnant Syphilis among Women Attending Antenatal Clinics in Shenzhen (China) in 2003

    Institute of Scientific and Technical Information of China (English)

    Yang Fan(杨帆); Zhou Hua(周华); Hong Fuchang(洪福昌); Luo Bin(罗斌); Cai Yumao(蔡于茂); Wen Lizhang(文立章); Zhang Chunlai(张春来)


    Abstract Background: The Nnewly reported cases of congenital syphilis have been increaseding substantially over the past few years. To control the epidemic, a municipal program aimed at preventing mother-to-child transmission of syphilis was introduced in July, 2001,which was designed aimed to screen all pregnant women for syphilis at their first visit to antenatal clinics or at admission to hospitals in Shenzhen.Objectives: The aim of the study is tTo determine the prevalence of syphilis among women attending antenatal clinics and other medical institutions in Shenzhen and identifies its patterns of infection.Methods: Upon giving informed consent, w Women who attended antenatal care centers in Shenzhen from January to December 2003 were included in this study subject to obtaining informed consent. A blood sample was harvested for syphilis screened for syphilising by using rapid plasma reagent test (RPR) and confirmed by TPHA for those who were RPR positive. The women with pregnant syphilispositive serology were systematically interviewed to obtain. During the interview, their demographic detailsinformation, patterns of risk behaviors and other data. Data were collected andwere analyzed retrospectively.Results: Among Of 118,235 pregnant women surveyed,555 pregnant women were confirmed to have syphilis (prevalence of 4.69%), with a incidence of 4.69‰. 123women were excluded from the analysis because of incomplete medical records. Of 432 infected subjects with complete medical records, the average age was 26.8, with a range of 19 to 41. 7.41% (32/432) of them suffered from primary syphilis, 3.24% (14/432) were ofhad secondary syphilis, and 89.35%(386/432) had latent syphilis. Without any conspicuous clinical signs and symptoms. Conclusions: The prevalence of syphilis among the pregnant women in our series was high an most of them were asymptomatic. Screening for syphilis among pregnant women in Shenzhen is of importantce for the prevention of mother

  17. Domain Modeling: NP_001017973.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001017973.1 chr5 Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex w...ith a biologically active inhibitor p2hbta_ chr5/NP_001017973.1/NP_001017973.1_holo_319-533.pdb swppa 382S,416L,418V,427Y,430H,432D,453L,455Y,466V,484W,499H,509K,511V,515W FE2,UN9 0 ...

  18. Disease: H00917 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00917 Congenital dyserythropoietic anemias (CDAs) Congenital dyserythropoietic ane...olascon A, Russo R, Delaunay J Congenital dyserythropoietic anemias. Curr Opin Hematol 18:146-51 (2011) PMID...:21251457 (description, comment) Iolascon A, Russo R, Esposito MR, Piscopo C, Asci R, De Falco L, Di Noce F Congenital...(2011) PMID:20820969 (description) Kamiya T, Manabe A Congenital dyserythropoietic anemia. Int J Hematol 92:432-8 (2010) ...

  19. Association of single nucleotide polymorphisms in CYP1B1 and COMT genes with breast cancer susceptibility in Indian women. (United States)

    Yadav, Sharawan; Singhal, Naveen Kumar; Singh, Virendra; Rastogi, Neeraj; Srivastava, Pramod Kumar; Singh, Mahendra Pratap


    Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) enzymes play critical roles in estrogen metabolism. Alterations in the catalytic activity of CYP1B1 and COMT enzymes have been found associated with altered breast cancer risk in postmenopausal women in many populations. The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT. The present study was performed to evaluate the associations of CYP1B1 Leu(432)Val and/or COMT Val(158)Met polymorphisms with total, premenopausal and postmenopausal breast cancer risks in Indian women. COMT and CYP1B1 polymorphisms in controls and breast cancer patients were analyzed employing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) followed by gel electrophoresis. Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast cancer risks when analyzed individually, COMT wild type (Val(158)Val) in combination with CYP1B1 heterozygous variant (Leu(432)Val) [OR: 0.21; 95% CI (0.05-0.82), p value; 0.021] and COMT heterozygous variant (Val(158)Met) in combination with CYP1B1 wild type (Leu(432)Leu) [OR: 0.29; 95% CI (0.08-0.96), p value; 0.042] showed significant protective association with premenopausal breast cancer risk. The results demonstrate that CYP1B1 wild type in combination with COMT heterozygous or their inverse combination offer protection against breast cancer in premenopausal Indian women.

  20. Association of Single Nucleotide Polymorphisms in CYP1B1 and COMT Genes with Breast Cancer Susceptibility in Indian Women

    Directory of Open Access Journals (Sweden)

    Sharawan Yadav


    Full Text Available Cytochrome P450 1B1 (CYP1B1 and catechol-$O$-methyltransferase (COMT enzymes play critical roles in estrogen metabolism. Alterations in the catalytic activity of CYP1B1 and COMT enzymes have been found associated with altered breast cancer risk in postmenopausal women in many populations. The substitution of leucine (Leu to valine (Val at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met at codon 158 decreases the catalytic activity of COMT. The present study was performed to evaluate the associations of CYP1B1 Leu432Val and/or COMT Val158Met polymorphisms with total, premenopausal and postmenopausal breast cancer risks in Indian women. COMT and CYP1B1 polymorphisms in controls and breast cancer patients were analyzed employing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP followed by gel electrophoresis. Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast cancer risks when analyzed individually, COMT wild type (Val158Val in combination with CYP1B1 heterozygous variant (Leu432Val [OR: 0.21; 95% CI (0.05–0.82, p value; 0.021] and COMT heterozygous variant (Val158Met in combination with CYP1B1 wild type (Leu432Leu [OR: 0.29; 95% CI (0.08–0.96, p value; 0.042] showed significant protective association with premenopausal breast cancer risk. The results demonstrate that CYP1B1 wild type in combination with COMT heterozygous or their inverse combination offer protection against breast cancer in premenopausal Indian women.

  1. Real-Time, Polyphase-FFT, 640-MHz Spectrum Analyzer (United States)

    Zimmerman, George A.; Garyantes, Michael F.; Grimm, Michael J.; Charny, Bentsian; Brown, Randy D.; Wilck, Helmut C.


    Real-time polyphase-fast-Fourier-transform, polyphase-FFT, spectrum analyzer designed to aid in detection of multigigahertz radio signals in two 320-MHz-wide polarization channels. Spectrum analyzer divides total spectrum of 640 MHz into 33,554,432 frequency channels of about 20 Hz each. Size and cost of polyphase-coefficient memory substantially reduced and much of processing loss of windowed FFTs eliminated.

  2. Activating Mutations of the TRPML1 Channel Revealed by Proline-scanning Mutagenesis*



    The mucolipin TRP (TRPML) proteins are a family of endolysosomal cation channels with genetically established importance in humans and rodent. Mutations of human TRPML1 cause type IV mucolipidosis, a devastating pediatric neurodegenerative disease. Our recent electrophysiological studies revealed that, although a TRPML1-mediated current can only be recorded in late endosome and lysosome (LEL) using the lysosome patch clamp technique, a proline substitution in TRPML1 (TRPML1V432P) results in a...

  3. AcEST: BP921400 [AcEST

    Lifescience Database Archive (English)

    Full Text Available OS=Vitis... 80 1e-16 tr|Q4PS97|Q4PS97_SOLLC Hexokinase OS=Solanum lycopersicum GN=HXK... 77 2e-15 tr|A3A1E3...AELLGE 3 Y F++YL E + E+LGE Sbjct: 415 YTMFKEYLHEALCEILGE 432 >tr|Q4PS97|Q4PS97_SOLLC Hexokinase OS=Solanum l

  4. Hospitalidade em festivais: avaliação comparada das Oktoberfest de Munique (RFA) e Blumenau (SC/Brasil)


    Sérgio Luiz do Amaral Moretti; Cícera Carla Bezerra da Silva; Rita de Cássia Pinotti; Fabrícia Durieux Zucco


    The study of hospitality allows the understanding of the human relationships at the time of receiving the other and has become important concept to understand the perception of quality and customer satisfaction. Increased interest in festivals has led organizers to devote more attention to it. This article seeks to examine the subject and to this end we applied a survey in Oktoberfest Munich (Germany) with 285 inquiries and, of Blumenau (S / C, Brazil) with 432 inquiries based on SERVQUAL usi...

  5. Hypertension in Mexican adults: results from the National Health and Nutrition Survey 2006 Hipertensión en adultos mexicanos: resultados de la Encuesta Nacional de Nutrición y Salud 2006


    Simón Barquera; Ismael Campos-Nonato; Lucía Hernández-Barrera; Salvador Villalpando; César Rodríguez-Gilabert; Ramón Durazo-Arvizú; Aguilar-Salinas, Carlos A.


    OBJECTIVE: To describe the prevalence of hypertension among Mexican adults, and to compare to that observed among Mexican-Americans living in the US. MATERIAL AND METHOD: The primary data source came from adults (>20 years) sampled (n=33366) in the Mexican National Health and Nutrition Survey 2006 (ENSANUT 2006). Hypertension was defined when systolic blood pressure was >140 and/or diastolic was >90 or patients previously diagnosed. RESULTS: A total of 43.2% of participants were classified as...

  6. Sex-induced cystitis: An epidemiological study in female populations of three district of rural Thebes, Greece


    Georgakopoulos G; Stamatiou K; Ilias G; Karanasiou V; Christakis M; Matsagoura M; Papadimitriou V; Heretis J; Daskalopoulos G


    The aim of our study was to examine the frequency and characteristics of recurrent lower urinary tract infections (LUTIs) due to sexual intercourse (sex-induced cystitis - SIC) in female population of three districts of the rural Thebes targeted to investigate the influence of age and culture on its epidemiology. We examined 432 women between 15 and 65 years of age in female populations of three district of the rural areas of Thebes between May 2006 and January 2007 with symptoms of recurrent...

  7. Risk of resistance related to antibiotic use before admission in patients with community-acquired bacteraemia

    DEFF Research Database (Denmark)

    Pedersen, Gitte; Schønheyder, Henrik Carl; Steffensen, Flemming Hald


    %), Streptococcus pneumoniae (23%) Staphylococcus aureus (10%). Of the 575 isolates of E. coli, 425 (74%), 432 (75%) and 518 (90%) were susceptible to ampicillin, sulphonamides and trimethoprim, respectively. Previous antibiotic prescriptions were strongly associated with resistance to ampicillin, sulphonamides...... admission and to 37% during the 6 months. The most frequently prescribed antibiotics within 30 days were ampicillin (28%), penicillin G (27%), sulphonamides and/or trimethoprim (16%) and macrolides (14%). The most frequent blood isolates were Escherichia coli (33%), other Enterobacteriaceae 8...

  8. The Musculoskeletal Readiness Screening Tool-Injury Predictor for United States Military Academy Preparatory Cadets (United States)


    future injury, 430 logistic regression models were performed . Predictor variables were determined by 431 analyzing individual component scores on the...MRST, the composite MRST score, 432 past history of injury, and personal concern for injury. Data analysis was performed 433 using R Core Team...PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION

  9. Attlee, the Chiefs of Staff and the Restructuring of ’Commonwealth Defence’ between VJ Day and the Outbreak of the Korean War. (United States)


    19 February 1947, T.O.P., Vol IX, No. 432, pp. 766. - 105- =... India, objected that Wavell had already been authorized to tell Nehru and Jinnah of...between Pakistan and India. I have also mentioned this to Jinnah who was equally pleased. 12 1 In his report after the meeting of the JDC he reported...recommendation in due course. The violence that followed partition shunted any plans for immediate defence negotiations with the new dominions, at least for the

  10. Shari’a Compliant Finance: The Overlooked Element for Developing an Effective Financial System in Afghanistan (United States)


    oversight, retail banking, small and medium enterprise finance, and microfinance . USAID also provided advice on how to implement on-site examinations of... microfinance market assessment in Syria and found that 43.2 percent of the population only wanted to use SCF because they perceived conventional...4CFC-8D5B-1 090 18D30895113298/BPSESJatengenglish.pdf (accessed 28 September 20 11 ), 21. 90 Grameen-Jameel Pan-Arab Microfinance Limited and the

  11. Modelling Agent-Environment Interaction in Multi-Agent Simulations with Affordances (United States)


    RI, USA, 2004. AIAA. 14. Carole Bernon, Massimo Cossentino, and Juan Pavi. An overview of current trends in European AOSE research. Informatica , 29(5...Abdelkader Gouaich and Fabien Michel. Towards a unified view of the environment(s) within multi-agent systems. Informatica , 29(4):423–432, November 2005. 59...coordination in mas. Informatica , 29(4):433–443, November 2005. 128. Michael A. Riley and Marie-Vee Santana. Mutuality relations, observations, and

  12. Hábitos alimentarios de Mustelus lunulatus y M. henlei (Pisces: Triakidae) colectados en el Parque Nacional Natural Gorgona, Pacífico colombiano


    Gómez, G.O.; Zapata, L. A.; Franke A., R.; Ramos, G.E.


    From June 1988 to July 1992, non-continuous samples of two species of cartilaginous fish of the family Triakidae were taken in the National Natural Park Gorgona. Stomach contents of 139 individuals of Mustelus lunulatus and 51 individuals of M. henlei were analyzed. These species predate on crustaceans (93,06%), mainly Portunus iridiscens, Squilla panamensis and Hipoconcha panamensis, secondly on mollusks of the family Loliginidae (4,32%) and fishes (2,28%) in a smaller proportion; the remain...

  13. Organization of the Optical Society of America Photonic Science Topical Meeting Series. Volume 14. Photorefractive Materials Effects, and Devices Held in Beverly, Massachusetts on 29-31 July 1991 (United States)


    Laboratories Peter Gunter Swiss Federal Institute of Technology, Switzerland Tom Pollak Sanders Associates Daniel Rytz Sandoz Optoelectronique , Switzerland...photorefractive quantum MJlA, NEW MATERIALS well structures, Q. N. Wang, D. D. Nolte, M. R. Melloch, Pur- Daniel Rytz, Sandoz Optoelectronique , Switzerland...are presented and discussed. (p. 432) xiv New Materials MA 8:30am-10:00am Academic Center Auditorium Daniel Rytz, Presider Sandoz Optoelectronique

  14. Design and Evaluation of NUSC’s Flow Loop Facility. (United States)


    Layer," Journal of Fluid Mechanics, vol. 5, 1959. 2. J.L. Lumley and J.F. McMahon, "Reducing Water Tunnel Turbulence by Means of a Honeycomb," Journal of...18 tr% W U%12.. INITIAL DISTRIBUTION LIST Addressee No. of Copies CUR COUR-432, R. Whitehead, M. Reischman) 2 NAVSEA CSEA -05R32, J. DeCorpo; 6 S&A

  15. Fledgling Psychopathy in the Classroom: ADHD Subtypes Psychopathy, and Reading Comprehension in a Community Sample of Adolescents


    DeLisi, Matt; Vaughn, Michael; Beaver, Kevin M.; Wexler, Jade; Barth, Amy E.; Fletcher, Jack M.


    The current study explores characteristics that are associated with fledgling psychopathy and educational outcomes relating to reading comprehension performance in a community sample of 432 middle school students. Latent class analysis (LCA) produced a four-class solution. Class 1 was a large (71.5% of sample) ‘‘control’’ group of youths with no attention/hyperactivity deficits and the highest reading comprehension scores. Class 2 was 11.6% of the sample and was consistent with traits associa...

  16. Development of Behavioral Toxicology Methodology for Interactive Exposure Regimens. (United States)


    include forest fires, terpene oxidation, and the oceans (National Academy of Science, 1977). The principal anthropogenic source is the incomplete...Carboxyhemoglobin in Blood 1. Principle of the Method Absorbance measurements are made in the Soret region at a blood .dilution of approximately 1:1000. The...thus providing the two component system COHb-Hb for absorbance measurements -at 420 and 432 nm. At 420 nm. the absorbance of COHb is about double

  17. The Vibrio cholerae Mrp system: cation/proton antiport properties and enhancement of bile salt resistance in a heterologous host. (United States)

    Dzioba-Winogrodzki, Judith; Winogrodzki, Olga; Krulwich, Terry A; Boin, Markus A; Häse, Claudia C; Dibrov, Pavel


    The mrp operon from Vibrio cholerae encoding a putative multisubunit Na(+)/H(+) antiporter was cloned and functionally expressed in the antiporter-deficient strain of Escherichia coli EP432. Cells of EP432 expressing Vc-Mrp exhibited resistance to Na(+) and Li(+) as well as to natural bile salts such as sodium cholate and taurocholate. When assayed in everted membrane vesicles of the E. coli EP432 host, Vc-Mrp had sufficiently high antiport activity to facilitate the first extensive analysis of Mrp system from a Gram-negative bacterium encoded by a group 2 mrp operon. Vc-Mrp was found to exchange protons for Li(+), Na(+), and K(+) ions in pH-dependent manner with maximal activity at pH 9.0-9.5. Exchange was electrogenic (more than one H(+) translocated per cation moved in opposite direction). The apparent K(m) at pH 9.0 was 1.08, 1.30, and 68.5 mM for Li(+), Na(+), and K(+), respectively. Kinetic analyses suggested that Vc-Mrp operates in a binding exchange mode with all cations and protons competing for binding to the antiporter. The robust ion antiport activity of Vc-Mrp in sub-bacterial vesicles and its effect on bile resistance of the heterologous host make Vc-Mrp an attractive experimental model for the further studies of biochemistry and physiology of Mrp systems.

  18. Circadian KaiC phosphorylation: a multi-layer network.

    Directory of Open Access Journals (Sweden)

    Congxin Li


    Full Text Available Circadian KaiC phosphorylation in cyanobacteria reconstituted in vitro recently initiates a series of studies experimentally and theoretically to explore its mechanism. In this paper, we report a dynamic diversity in hexameric KaiC phosphoforms using a multi-layer reaction network based on the nonequivalence of the dual phosphorylation sites (S431 and T432 in each KaiC subunit. These diverse oscillatory profiles can generate a kaleidoscopic phase modulation pattern probably responsible for the genome-wide transcription rhythms directly and/or indirectly in cyanobacteria. Particularly, our model reveals that a single KaiC hexamer is an energy-based, phosphorylation-dependent and self-regulated circadian oscillator modulated by KaiA and KaiB. We suggest that T432 is the main regulator for the oscillation amplitude, while S431 is the major phase regulator. S431 and T432 coordinately control the phosphorylation period. Robustness of the Kai network was examined by mixing samples in different phases, and varying protein concentrations and temperature. Similar results were obtained regardless of the deterministic or stochastic method employed. Therefore, the dynamic diversities and robustness of Kai oscillator make it a qualified core pacemaker that controls the cellular processes in cyanobacteria pervasively and accurately.

  19. Association of CYP1B1 Polymorphisms with Breast Cancer: A Case-Control Study in the Han Population in Ningxia Hui Autonomous Region, P. R. China

    Directory of Open Access Journals (Sweden)

    Haiyan Jiao


    Full Text Available Studies investigating possible associations between cytochrome P4501B1 (CYP1B1 polymorphisms and breast cancer risk have been inconsistent. We set out to ascertain whether there might be an association between polymorphisms in exon 2 (codon 119, G→T and exon 3 (codon 432, G→C of CYP1B1 and breast cancer in a Chinese Han population in the rural region of Ningxia. Using an allele-specific polymerase chain reaction method and direct DNA sequencing, the presence or absence of the two CYP1B1 polymorphisms was investigated. Genotype and allele frequencies were analyzed in breast cancer cases (n = 152 and healthy age-matched controls (n = 156. The odds ratio (OR of 119G→T or 432G→C in breast cancer cases and controls was 3.3 (95% CI: 1.28 to 8.28 and 2.8 (95% CI: 1.04 to 7.51, respectively. In addition, the OR for people with both polymorphisms (119T and 432C was 4.69 (95% CI: 1.97 to 11.19. Our results suggest that certain polymorphisms in the CYP1B1 gene might increase risk for breast cancer among Han Chinese, perhaps because they influence the efficiency of CYP1B1 bio-transformation of oestrogens or pro-carcinogens into DNA- reactive electrophiles that may act as cancer-initiating agents.

  20. Association between the CYP1B1 polymorphisms and risk of cancer: a meta-analysis. (United States)

    Liu, Jie-Ying; Yang, Yu; Liu, Zhi-Zhong; Xie, Jian-Jun; Du, Ya-Ping; Wang, Wei


    The previous, published data on the association between CYP1B1 polymorphisms and cancer risk remained controversial. To derive a more precise estimation of the association between the CYP1B1 polymorphisms and cancer risk, we performed a meta-analysis to investigate the association between cancer susceptibility and CYP1B1 Leu432Val, Asn453Ser, Arg48Gly, and Ala119Ser polymorphisms. For Asn453Ser and Arg48Gly polymorphisms, significantly decreased endometrial cancer was observed among Caucasians. For Ala119Ser polymorphism, we found that individuals with the minor variant genotypes had a high risk of prostate cancer. For Leu432Val polymorphism, we found that individuals with the minor variant genotypes had a higher risk of endometrial cancer and lung cancer and had a lower risk of ovarian cancer. In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians. In addition, our work also points out the importance of new studies for Ala119Ser polymorphism in endometrial cancer, because high heterogeneity was observed (I (2) > 75 %).

  1. Leu/Val SNP polymorphism of CYP1B1 and risk of uterine leiomyoma in a Black population. (United States)

    Bideau, Virgil S; Alleyne, Angela T


    Uterine leiomyoma (UL) is the most commonly occurring benign tumor that affects women of reproductive ages. Studies strongly suggest that ULs are hormonally dependent and that genes acting in estrogen metabolism might be involved in their development. The focus of this case-control study was to determine whether the Leucine432Valine single-nucleotide polymorphism (SNP) in the gene encoding cytochrome P450 1B1 (CYP1B1) was associated with an increased risk of UL in Black Barbadian women. The investigation comprised 37 women clinically diagnosed with UL and 52 controls. The CYP1B1 Leu432Val polymorphism (Leu/Val) was analyzed using the polymerase chain reaction-restriction fragment length polymorphism method. The homozygous Valine432 variant (Val/Val) was predominant in both cases and controls for this population (89 and 83 %, respectively). The odds ratio for risk of developing the disease was 1.33, but this was not statistically significant. We discuss a possible protective function for CYP1B1 based on the high prevalence of this mutant SNP and its lack of association with UL.

  2. Assessing the sound quality of a grand piano for different tuning standards (United States)

    Fastl, Hugo


    Grand pianos are tuned to a standard frequency of 440 Hz for a4. Eighty years ago, the tuning standard was lower, around 432 Hz. In Germany, a group of music lovers insists that the sound quality of a grand piano when tuned to 432 Hz is much superior to that of the same instrument when tuned to 440 Hz. Therefore, well-controlled psychoacoustic experiments were performed to check the validity of that argument. Using a Welte-Steinway reproduction grand piano of the Deutsches Museum Muenchen, with the exception of the tuning, all other features of the pieces of music used as stimuli could be kept the same. The advantage of using the Welte-Steinway lies in the fact that reproductions of the music of famous (deceased) artists are available, who at their time performed at a lower tuning standard. Recordings of the music played at 432 vs 440 Hz were made on DAT and presented to the subjects via headphones for sound quality evaluation. Psychophysical procedures like semantic differential or preference scaling by ``random access'' that have proven successful for the assessment of sound quality in the context of car interior sounds were used in the experiments.

  3. [Immunohistochemical study using a double fluorescent staining on the regional lymph nodes of gastric cancers]. (United States)

    Chono, S


    For the purpose to investigate the immunological anti-tumor function of lymphocytes in the regional lymph nodes of gastric cancer, a double staining procedure using several monoclonal antibodies against the surface membranes of T and NK cells with fluorescent antibody technique was conducted. The number of CD11b+ cells out of CD8+ cells was small with almost all being CD11b- belonging to cytotoxic T cells. Leu8+ cells and Leu8- cells out of CD4+ cells were recognized in equal numbers and were reciprocal. The ratio of CD4+ Leu8-/CD4+ demonstrated an increase in the group injected with OK-432. The ratio of OKT9+ or OKIa1+ occupied in CD8+ or CD4+ cells was only several percent, and few in number. An increase for the ratio of CD4+ OKT9+/CD4+ was observed in the group injected with IL-2. Similar increases for the ratio of CD4+ OKIa1+/CD4+ were obtained in the group injected with OK-432 and in the metastatic group, respectively. The Leu7+ CD16+ cells were not observed. The Leu7- CD16+ cells were observed in a part where metastases were focused. These results indicated that lymphocytes in regional lymphocyte of gastric cancer might hold the hidden anti-tumor effect, but did not display the full function without preoperative intratumor injection of BRM such as IL-2 or OK-432.

  4. Cytochrome P1B1 (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis. (United States)

    Gajjar, Ketan; Owens, Gemma; Sperrin, Matthew; Martin-Hirsch, Pierre L; Martin, Francis L


    CYP1B1 is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates and plays a key role in hormone-induced carcinogenesis. Risk factors for ovarian cancer are related to hormonal exposure and reproduction, and polymorphisms within genes involved in metabolism of oestrogen and certain xenobiotics may influence the risk of developing ovarian cancer. Current meta-analysis evaluated four CYP1B1 polymorphisms (Leu432Val, Arg48Gly, Ala119Ser and Asn453Ser) for their association with ovarian cancer risk. A search of the MEDLINE bibliographic database for the period up to April 2012 identified five relevant studies. With regards to Leu432Val polymorphism, all of the five studies were eligible (1199 cases and 2596 controls) for analysis, while for Arg48Gly (799 cases and 1169 controls), Ala119Ser (799 cases and 1172 controls) and Asn453Ser (361cases and 1577 controls) only two studies were eligible for analysis. Fixed-effect models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (95% CI) and chi-square based Q-test was used to test for heterogeneity. The pooled OR (95% CI) for CYP1B1_Leu432Val polymorphism were 1.1 (0.84-1.31) for heterozygous subjects and 0.82 (0.57-1.17) for homozygous Val subjects. In a recessive model, homozygous carriers of Leu432Val showed a weak trend towards reduced risk as compared to 'wild type' and heterozygous carriers (OR 0.8, 95% CI; 0.66-0.99); however, this association was of limited significance. Regarding Arg48Gly, the pooled OR (95% CI) were 1.06 (0.89-1.27) for heterozygous and 0.98 (1.72-1.33) for homozygous Gly subjects. With respect to Ala119Ser and Asn453Ser, the pooled OR were 1.06 (0.87-1.29) and 1.24 (0.94-1.63) for heterozygous and 1.1 (0.8-1.52) and 1.09 (0.5-2.34) for homozygous respectively. In conclusion, this meta-analysis suggests that CYP1B1 polymorphisms are not associated with ovarian cancer risk. Studies evaluating CYP1B1_Leu432Val polymorphism are required to

  5. Association between gene polymorphism of CYP1B1 and susceptibility to endometrial cancer%CYP1B1基因多态性与子宫内膜癌易感性的关系

    Institute of Scientific and Technical Information of China (English)

    张丹; 卢爱妮; 廖予妹


    目的 研究CYP1B1基因外显子3密码子432(C-G)多态性与子宫内膜癌易感性的关系.方法 应用聚合酶链反应-限制性片断长度多态性分析(PCR-RFLP)技术检测76例子宫内膜癌患者和83例对照者的CYP1B1基因密码子432(C-G)位点多态性,并分析CYP1B1基因多态性与子宫内膜癌易感性的相关性.结果 CYP1B1基因密码子432中等位基因C、G在子宫内膜癌组和对照组分布的差异有统计学意义(P<0.05),其中等位基因G使子宫内膜癌发病风险增加2.24倍.CYP1B1基因密码子432C/G各基因型分布两组间差异有统计学意义(P<0.05),纯合突变(G/G)基因型、杂合突变(C/G)基因型与野生(C/C)基因型相比,患子宫内膜癌的危险度分别提高了5.62倍和2.04倍.结论 CYP1B1基因Leu432Val多态性与子宫内膜癌的发生有一定的关系,突变基因型增加子宫内膜癌的发病风险.

  6. CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population. (United States)

    Sillanpää, Pia; Heikinheimo, Liisa; Kataja, Vesa; Eskelinen, Matti; Kosma, Veli-Matti; Uusitupa, Matti; Vainio, Harri; Metsola, Katja; Hirvonen, Ari


    We investigated the associations between two CYP1A1 polymorphisms (Ile462Val and Thr461Asn) and one CYP1B1 polymorphism (Leu432Val) and breast cancer risk. The study population consisted of 483 breast cancer patients and 482 healthy population controls, all of homogenous Finnish origin. No statistically significant overall associations were found between the CYP1A1 and CYP1B1 genotypes and breast cancer risk. However, a significant increase in the breast cancer risk was seen for women who had smoked 1-9 cigarettes/day and carried the CYP1B1 432Val allele; the OR was 2.6 (95% CI 1.07-6.46) for women carrying the Leu/Val genotype and 5.1 (95% CI 1.30-19.89, P for trend 0.005) for women with the Val/Val genotype compared to similarly smoking women homozygous for the 432Leu allele. Furthermore, when CYP1B1 genotypes were combined with the previously analyzed N-acetyl transferase (NAT2) genotypes, a significant increase in breast cancer risk was found among women who had at least one CYP1B1 432Val allele together with the NAT2 slow acetylator genotype (OR 1.52; 95% CI 1.03-2.24) compared to women carrying a combination of CYP1B1 Leu/Leu and NAT2 rapid acetylator genotypes. This risk was seen to be confined to ever smokers; the OR was 2.46 (95% CI 1.11-5.45) for ever smokers carrying at least one CYP1B1 432Val allele together with the NAT2 slow acetylator genotype compared to ever smokers with the CYP1B1 Leu/Leu and NAT2 rapid acetylator genotype combination. Our results suggest that the CYP1B1 polymorphism may be an important modifier of breast cancer risk in Finnish Caucasian women who have been exposed to tobacco smoke and/or carry the NAT2 slow acetylator genotype.

  7. Cytochrome P450 1B1 polymorphisms and risk of renal cell carcinoma in men. (United States)

    Chang, Inik; Fukuhara, Shinichiro; Wong, Darryn K; Gill, Ankurpreet; Mitsui, Yozo; Majid, Shahana; Saini, Sharanjot; Yamamura, Soichiro; Chiyomaru, Takeshi; Hirata, Hiroshi; Ueno, Koji; Arora, Sumit; Shahryari, Varahram; Deng, Guoren; Tabatabai, Z Laura; Greene, Kirsten L; Shin, Dong Min; Enokida, Hideki; Shiina, Hiroaki; Nonomura, Norio; Dahiya, Rajvir; Tanaka, Yuichiro


    The cytochrome P450 1B1 (CYP1B1) enzyme activates xenobiotics to reactive forms as well as convert estradiol to 4-hydroxy-estradiol that has been shown to play a role in the carcinogenesis process of the kidney in male but not female animals. Prior reports show polymorphic variants of CYP1B1 to alter catalytic activity, and thus, we hypothesize that polymorphisms of the CYP1B1 gene are involved in the malignant transformation of the renal cell in men. The genetic distributions of five CYP1B1 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism in 480 normal healthy subjects and 403 sporadic renal cell carcinoma cases. All subjects were Caucasian men. The sites evaluated were codons 48 (C → G, Arg → Gly, rs10012), 119 (G → T, Ala → Ser, rs1056827), 432 (C → G, Leu → Val, rs1056836), 449 (C → T, Asp, rs1056837), and 453 (A → G, Asn → Ser, rs1800440). A trend was demonstrated for the 432 Val/Val (χ2, P = 0.06) and 449 T/T (χ2, P = 0.1) genotypes to play a protective role against renal cancer. Odds ratio (95 % confidence interval) for Val/Val compared to Leu/Leu at codon 432 was 0.65 (0.44-0.95) and T/T compared to C/C at codon 449 was 0.67 (0.45-0.99). Codons 432 and 449 were observed to be linked (D = 0.24), and haplotype involving 432 Val and 449 T was significantly reduced in cancer cases (P = 0.04). No association was found, however, when analyzing polymorphic sites with clinical stage of cancer. These results demonstrate polymorphisms of CYP1B1 to be associated with renal carcinogenesis and are of importance in understanding their role in the pathogenesis of renal cell carcinoma.

  8. 术后妊娠对年轻乳腺癌患者预后的影响%Effect of postoperative pregnancy upon prognosis of young breast cancer patients

    Institute of Scientific and Technical Information of China (English)

    吴佳毅; 沈坤炜; 邵志敏; 沈镇宙; 陈灿铭; 张家新; 侯意枫; 胡震; 柳光宇; 狄根红; 吴炅; 陆劲松


    目的 评估术后妊娠对中国年轻女性乳腺癌患者预后的影响.方法 对1989年3月至2007年7月于我院治疗的432例年轻(≤35岁)单侧乳腺癌患者进行回顾性研究,分析术后妊娠对预后的影响,用Kaplan-Meier法进行生存分析,Log Rank法比较不同患者的生存差异,用Cox回归分析对患者进行多因素回归分析.结果 432例年轻乳腺癌患者中共有18例术后妊娠,其中5例足月产,13例流产,最早妊娠的时间为术后17个月.中位随访62个月(6~237个月),432例患者的无病生存率(DFS)为72.5%(313/432),总体生存率(OS)为88.7%(383/432).Cox回归多因素分析发现术后妊娠、临床分期及病理腋窝淋巴结转移数对患者的DFS有显著影响,只有淋巴结转移数对患者的OS有显著影响.由于术后妊娠的患者中并未出现死亡,Cox回归分析中术后妊娠对预后并无显著影响.结论 年轻乳腺癌患者手术后妊娠对预后无不良影响.%Objective To examine the effect of postoperative pregnancy upon the prognosis of young Chinese breast cancer patients. Methods Four hundred and thirty-two female unilateral breast cancer patients aged 35 or younger were retrospectively reviewed. Kaplan-Meier analysis and Log Rank test were used for univariate analysis of factors predictive of disease-free survival (DFS) and overall survival (OS). Multivariate analysis was carried out using the Cox proportional hazards model. Results Eighteen patients were identified to have postoperative pregnancy, including 5 full-term pregnancy and 13 abortions with the earliest pregnancy taking place at Month 17 post-operation. After a median follow-up of 62 months (6-237 months), the DFS and OS rates were 72. 5% (313/432) and 88. 7% (383/432) respectively. On multivariate analysis, postoperative pregnancy, clinical stage and number of pathologically involved axillary lymph node were significantly associated with DFS. And the axillary lymph node status was also

  9. Relationship between polymorphisms of CYP1A1, CYP1B1 genes and susceptibility to recurrent abortion%CYP1A1和CYP1B1基因多态性与RPL易感性

    Institute of Scientific and Technical Information of China (English)

    朱壮彦; 赵富玺; 富晓敏; 穆雅琴; 畅学艳


    Objective To investigate the relationship between polymorphisms of CYP1A1 and CYP lBlgenes and the susceptibility to recurrent pregnancy loss(RPL). Methods The Mspl polymorphism of CYP1A1 and the polymorphism in exon 3 codon 432(C-G of CYP1B1) were detected with the methods of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele specific-PCR (AS-PCR) in a case-control study including 81 cases of RPL and 98 healthy controls. Results There was no significant correlation between Mspl polymorphism and RPL susceptibility (x2 =0. 335 ,P =0. 846). There were significant differences in the genotype distributions or allele frequencies of CYP1B1 L432V polymorphism between the two groups (x2 = 7. 467 , P = 0. 024;x2 = 9. 129, P = 0. 003). Compared with wild-type C/C,the susceptibility of recurrent abortion with the genotypes of homozygotic mutation G/G and heterozygotic mutation C/G were increased by 2. 620 and 1. 954 times,respectively. Compared with allele C,the risk of recurrent abortion with allele G was increased by 2. 038. Conclusion The gene polymorphism of CYP1B1 in exon 3 condon 432 (C-G) might be a genetic risk factor of RPL and the allelic polymorphism of CYP1B1 L432V increases the risk of recurrent abortion. The results do not show that polymorphism of Mspl is associated with the susceptibility of RPL.%目的 探讨CYP1A1、CYP1B1基因多态性与复发性流产(RPL)遗传易感性关系,为预防和治疗该病提供新靶点.方法 本研究采用等位基因特异性PCR (As-PCR)和聚合酶链反应-限制性片断长度多态性(PCRRFLP)方法,针对CYP1A1基因MspI酶切位点和CYP1B1 L432V多态位点,检测81例患有原因不明RPL病例组和98名有生育史健康女性对照组之间差异.结果 RPL组和对照组CYP1A1 MspI位点3种基因型m1/m1、m1/m2、m2/m2分布频率差异无统计学意义(x2=0.335,P>0.05);CYP1B1 L432V多态位点3种基因型C/C、C/G、G/G在病例组和对照组分

  10. CYP1B1基因多态性与食管鳞状细胞癌易感性及预后关系的研究%Association of CYP1B1 gene polymorphism with prognosis of esophageal squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    刘月平; 张玲玲; 王顺平; 李洁; 安景辉; 王小玲


    目的 探讨CYP1B1基因C432G及A453G两个多态性住点分布频率特征与食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)之间的相关性;分析其与临床病理指标及预后的关系.方法 以河北医科大学第四医院2004年间120例有完整随访资料的ESCC患者术后石蜡包埋组织为研究对象,以120例内镜检查的食管正常组织标本作为对照组,酚氯仿法抽提基因组DNA,PCR-SSP法检测CYP1B1基因C432G及A453G两个多态性位点基因型分布频率,分析各基因型与ESCC患者临床病理特征及其发病风险的相关性.COX回归模型进行多因素生存分析,Kaplan-Meier生存曲线进行单因素生存分析,Log-Rank法比较各基因型5年生存率的差别.结果 CYP1B1 A453G位点不具多态性;CYP1B1 C432G基因CC、CG、GG基因型在ESCC患者组与对照组的分布频率分别为67.50%、18.33%、14.17%和74.17%、17.50%、8.33%,无明显统计学差异(P>0.05).G等位基因携带者患病风险是CC基因型.的1.477倍(OR=1.477,95% CI=0.942~2.317).临床病理特征分析结果显示CYP1B1 C432G基因CG、GG基因型在有淋巴结转移组和临床分期较晚组分布频率较高.Kaplan-Meier单变量分析结果表明CG+GG基因型患者5年生存率明显低于CC基因型患者.而COX模型多因素生存分析结果提示CYP1B1 C432G基因多态性与ESCC5年生存率无关. 结论 食管癌组和对照组CYP1B1 A453G等位基因多态性均为AA基因型,中国河北汉族人群此位点可能不存在多态性.C432G等位基因具有多态性.CYP1B1 C432G基因多态性可能与增加ESCC的易感性无关联,但与ESCC患者是否有淋巴结转移和临床分期相关,CG+GG基因型可能是预测ESCC患者不良预后的辅助指标.

  11. Physical, Chemicals and Flavors of Some Varieties of Arabica Coffee

    Directory of Open Access Journals (Sweden)

    Yusianto .


    Full Text Available Export of Arabica coffee was 28,100 tons/year or 8.28% total export of Indonesian coffee, most of them are specialty coffee. Beside their origin, variety and determine the of physical, chemical and flavors characters. The promising clones or varieties i.e. BP 416A, BP 418A, BP 430A, BP 431A, BP 432A, BP 507A, BP 508A, BP 509A, BP 511A, BP 513A, BP 516A, BP 517A and BP 518A still not be determined their quality This research was conducted to analyze their physicals, chemicals and flavors during 2 periods of harvesting (2004 and 2005, using AS 1, S 795 and USDA 762 as the control. Mature coffee berry was harvested, sorted manually, and depulped, cleaned manually and then fermented in plastic sacks during 36 hours. The fermented parchment was washed, and then sun dried, dehulled to get green coffee. Observations wre conducted on green coffee yield, husk content, color of green coffee, distribution of size, bulk density of green and roasted coffee, roasting characters, color of roasted beans, and pH, acidity and flavors. The results showed (a The lowest content of husk was BP 432A and the highest was USDA 762. The control varieties of AS 1, S 795 and USDA 762, showed husk content >15%, while those potential varieties were < 15% except BP 416A. (b Beans size >6,5 mm and more than 80% were BP 416A, BP 430A, BP 432A, BP 509A, P 88 and S 795. Green coffee of BP 430A, BP 432A and BP 509A were uniform, but S 795 was not uniform. AS 1 and BP 416A and P 88 was one group; S 795 was one group with BP 542A; BP 509 was a group with BP 432A; but BP4 30A and USDA 762 were the other groups. (c Green coffee of USDA 762 was the palest color, but BP 542A was the darkest color. AS 1 and S 795 were a group with all potential varieties, except BP 542A. (d Roasted coffee of USDA 762 was the palest color and AS 1 was the darkest. In this case, AS 1 was a group with BP 430A, BP 509A and P 88, while S 795 was a group with BP 416A and BP 432A, but USDA 762 and BP 542A were

  12. Anti-Tumor Effects of B16F10 Tumor Cell Lysate Vaccine in Mouse Melanoma%肿瘤细胞裂解物抗小鼠B16F10黑色素瘤的作用研究

    Institute of Scientific and Technical Information of China (English)

    路蕾; 刘景晶; 陈科; 刘彬; 王泽宇; 葛驰宇; 侯景; 金亮; 邢芸; 曹荣月


    反复冻融B16F10肿瘤细胞制备裂解物,以白喉毒素(Diphtheria toxin,DT)为载体,OK432和来源于结核分枝杆菌( Mycobacterium tuberculosis)热休克蛋白70(HSP70)第407-426( mHSP70407-426,M)的两段串联重复序列M2为佐剂,制备了肿瘤细胞疫苗B16F10-DT-M2-OK432(BDTMOK),探讨其能否抑制小鼠B16黑色素瘤,并且对其抗肿瘤的作用机理进行部分探讨.以制备的BDTMOK免疫C57BL/6小鼠,分别检测体液免疫应答和细胞免疫应答.通过ELISA法,从血清中检测到高滴度的抗B16肿瘤细胞裂解物(B16 tumor cell lysate,B16TCL)类抗体.淋巴细胞增殖实验的结果显示,BDTMOK的免疫能够有效的刺激脾淋巴细胞的增殖.预防结合治疗性实验的结果显示,BDTMOK激发的免疫应答对于B16肿瘤攻击起到有效的保护作用,与PBS阴性对照组比较,皮下注射BDTMOK可以延长皮下移植瘤发生的潜伏期(P<0.05),并且平均瘤重显著降低(P<0.05);抑制了小鼠皮内肿瘤模型中的血管新生(P<0.01).疫苗BDTMOK能有效的抑制小鼠B16黑色素瘤的生长.%To make tumor vaccine B16F10-DT-M2-OK432,the freeze-thaw method was adopted to obtain B16F10 tumor cell lysate. Diphtheria toxin( DT) ,OK432 or M2 which was two tandem repeats of sequence 407-426 of microbial HSP70 were selected as carrier and adjuvants respectively. The C57BL/6 mice were immunized with B16F10-DT-M2-OK432 in order to explore whether the tumor cell vaccine can effectively inhibit B16F10 melanoma in tumor-bearing mice and to study the mechanism of B16F10-DT-M2-OK432. After the last immunization, humoral immune and cellular immune response were detected. High tiler of anti-B16F10 tumor cell lysate antibody was detected in immunized mice sera by ELISA. Splenic lymophocyte proliferation assay results showed that the proliferation activity of splenocytes from mice immunized with B16F10-DT-M2-OK432 vaccine was significantly higher. The results of prophylactic/ therapeutic experiment

  13. 分散固相萃取-超高压液相色谱-串联质谱法测定黄瓜中的嗪胺灵%Determination of triforine in cucumber by dispersive solid phase extraction-ultra perssure liquid chromatography-electrospray ionization tandem mass spectrometry

    Institute of Scientific and Technical Information of China (English)

    陈武瑛; 张德咏; 李宗云; 何明远; 罗香文; 刘建宇; 刘绍文; 刘勇


    目的:建立黄瓜中嗪胺灵残留的液质串联快速分析检测方法。方法样品中的嗪胺灵经乙腈提取用 N-丙基乙二胺(PSA)和石墨化碳黑(GCB)净化,利用超高压液相色谱-串联质谱(UPLC-MS/MS)在多反应监测模式下进行检测。结果以碎片离子对432.8>212.9、432.8>82.9定性、离子对432.8>97.8进行外标法定量。仪器在0.01~1.00 mg/kg范围内,具有良好线性关系。在0.02~1.00 mg/kg添加水平范围内,嗪胺灵在黄瓜中的平均回收率为85.3%~92.2%,其相对标准偏差为2.8%~7.5%。该方法的检出限(LOD)为2.0μg/kg,定量限为(LOQ)为20μg/kg。结论本方法简便、快速、准确,能满足国内外法规的要求,可用于黄瓜样品中嗪胺灵的农药残留确证检测。%Objective A rapid method has been developed for the determination of germicide triforine re-sidues in cucumber. Methods The triforine from cucumber sample, which was extracted by acetonitrile and cleaned up by primary secondary amine (PSA) and graphitized carbon black (GCB), was determined by ultra perssure liquid chromatography-mass spectrometry under multiple reaction monitoring mode, then quantified by matrix-match standard solution. Results The qualitative results were obtained based on retention time, the precursor ion and three daughter ions, and the quantitation results were on the characteristic 432.8>212.9 ion, 432.8>82.9 ion and 432.8>97.8 ion. Average recoveries of triforine in cucumber samples were found in the range of 85.3%~92.2% at four spiking levels from 0.02 mg/kg to 1.0 mg/kg with relative standard deviations of 2.8%~7.5%. Limit of detections of triforine were 2.0 μg/kg, while limit of quantifications were 20 μg/kg, respectively. Conclusion The method is simple, rapid, and accurate, and it can meet the requirements of the domestic and international legislation. The method adapts to confirm residues of triforine pesticides in cu-cumber samples.

  14. Detection of Relationship between Polymorphisms of CYP1B1 and Susceptibility to Lung Cancer in Jiangsu Population by di-Allele-Specific-Amplification with Artificially Modified Primers%人工修饰双等位基因特异性引物扩增法检测CYP1B1多态性与肺癌易感性的关系

    Institute of Scientific and Technical Information of China (English)

    梁戈玉; 浦跃朴; 尹立红; 卜莹; 周国华


    [目的] 应用一种新的快速检测单核苷酸多态性(SNP)方法--人工修饰双等位基因特异性引物扩增(diASA-AMP)法研究CYP1B1基因Leu432Val位点多态性与江苏汉族人群肺癌易感性的关系.[方法] 采用配对病例-对照研究,收集江苏汉族人群原发性肺癌患者227例为病例组,同时按1∶1配对选择非肿瘤、非呼吸道疾病患者227例为对照组.应用diASA-AMP方法检测了病例组与对照组CYP1B1基因Leu432 Val位点多态性,分析Leu432 Val位点突变与肺癌易感性之间的关系.并应用测序法验证diASA-AMP法的特异性.[结果] CYP1B1基因Leu432Val位点突变C和G的基因频率在对照组和病例组的分布差异无显著性(χ2=0.201,P>0.05),单纯CYP1B1基因Leu432Val位点突变与肺癌危险性也不存在明显的相关关系(OR=1.085,95%CI=0.730~1.615),但该位点突变与吸烟可能有一定协同作用,携带G等位基因的基因型可增加吸烟者患肺癌的危险性(OR=2.057,95%CI=1.162~3.642).对照组的CYP1B1 C和G等位基因频率与现有的中国汉族人群资料结果相近,测序结果与diASA-AMP结果相符.[结论] CYP1B1 Leu432Val多态性可能是江苏汉族人群吸烟者肺癌发生的易感因素.diASA-AMP法可用于单核苷酸多态性的快速测定,特异性高,便于推广使用.


    Institute of Scientific and Technical Information of China (English)

    赵景颇; 韩硕; 马红


    [目的]探讨近年成人社区获得性尿路感染(CA-UTI)细菌病原学特点.[方法]采用法国Bio Merieux VITEK 2型全自动微生物仪对CA-UTI患者432株细菌进行菌种鉴定(ID卡)及药物敏感试验(AST卡),用WHONET5软件统计出细菌构成比与耐药率.[结果]检测标本的细菌分离率为39.1%(402/1027),检出细菌中革兰阴性菌占77.8%(336/432),其中大肠埃希菌占51.4%(222/432).革兰阴性菌对新型β-内酰胺类最敏感,其次为阿米卡星及第三代头孢菌素,对氨苄西林、头孢唑啉、磺胺等高度抗药.革兰阳性菌对左氧氟沙星、氨苄西林/舒巴坦及利福平等较敏感.[结论]成人CA-UTI病原菌构成在发生变迁,细菌的耐药性也在发生改变,做好各地各时期感染性疾病病原检测及耐药性监测,可提高病原学诊断水平和用药选择水平,提高医疗质量.

  16. Genome-scale metabolic analysis of Clostridium thermocellum for bioethanol production

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    Brooks J Paul


    Full Text Available Abstract Background Microorganisms possess diverse metabolic capabilities that can potentially be leveraged for efficient production of biofuels. Clostridium thermocellum (ATCC 27405 is a thermophilic anaerobe that is both cellulolytic and ethanologenic, meaning that it can directly use the plant sugar, cellulose, and biochemically convert it to ethanol. A major challenge in using microorganisms for chemical production is the need to modify the organism to increase production efficiency. The process of properly engineering an organism is typically arduous. Results Here we present a genome-scale model of C. thermocellum metabolism, iSR432, for the purpose of establishing a computational tool to study the metabolic network of C. thermocellum and facilitate efforts to engineer C. thermocellum for biofuel production. The model consists of 577 reactions involving 525 intracellular metabolites, 432 genes, and a proteomic-based representation of a cellulosome. The process of constructing this metabolic model led to suggested annotation refinements for 27 genes and identification of areas of metabolism requiring further study. The accuracy of the iSR432 model was tested using experimental growth and by-product secretion data for growth on cellobiose and fructose. Analysis using this model captures the relationship between the reduction-oxidation state of the cell and ethanol secretion and allowed for prediction of gene deletions and environmental conditions that would increase ethanol production. Conclusions By incorporating genomic sequence data, network topology, and experimental measurements of enzyme activities and metabolite fluxes, we have generated a model that is reasonably accurate at predicting the cellular phenotype of C. thermocellum and establish a strong foundation for rational strain design. In addition, we are able to draw some important conclusions regarding the underlying metabolic mechanisms for observed behaviors of C. thermocellum

  17. Cytochrome 450 1B1 (CYP1B1 polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC patients

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    Price Douglas K


    Full Text Available Abstract Background The selection of patients according to key genetic characteristics may help to tailor chemotherapy and optimize the treatment in Castration-Resistant Prostate Cancer (CRPC patients. Functional polymorphisms within the cytochrome P450 1B1 (CYP1B1 gene have been associated with alterations in enzymatic expression and activity and may change sensitivity to the widely used docetaxel regimen. Methods CYP1B1 genotyping was performed on blood samples of 60 CRPC patients treated with docetaxel, using TaqMan probes-based assays. Association between CYP1B1-142C>G (leading to the 48ArgGly transition, 4326C>G (432LeuVal, and 4390A>G (453AsnSer polymorphisms and treatment response, progression-free-survival (PFS and overall-survival (OS was estimated using Pearson χ2 test, Kaplan-Meier curves and Log-rank test. Results Patients carrying the CYP1B1-432ValVal genotype experienced a significantly lower response-rate (P = 0.014, shorter progression-free-survival (P = 0.032 and overall-survival (P Conclusions CYP1B1-4326C>G (432LeuVal polymorphism emerged as possible predictive marker of response and clinical outcome to docetaxel in CRPC patients and may represent a potential new tool for treatment optimization. Larger prospective trials are warranted to validate these findings, which might be applied to the future practice of CRPC treatment.

  18. [The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients]. (United States)

    Korytina, G F; Akhmadishina, L Z; Viktorova, T V


    Chronic obstructive pulmonary disease is a multifactorial respiratory disorder. Members of the cytochrome P450 family catalyze the oxidative metabolism of exogenous chemicals and activate their substrates into reactive intermediates that may initiate lung injury. The aim of this study was to learn interethnic variation in frequency distribution patterns of CYP1B1 and CYP2F1 genes polymorphic markers and to analyse its association withchronic obstructive pulmonary disease. The polymorphic markers Leu432Val(CYP1B1) and c.14_15insC(CYP2F1) were studied at chronic obstructive pulmonary disease patients (Russian (N=169), Tatar (N=137)) and cases of healthy individuals (Russian (N=191), Tatar (N=198) and Bashkir (N=78)), residents of Bashkortostan by PCR-RFLP method. It was shown that the CYP2F1 gene genotype frequency distribution patterns differed between three ethnic groups (chi2 = 21.29, df=4, P = 0.0001), because of high frequency of c.14_15insC/c.14_15insC genotype in Tatars (6.38%). On the other hand, high frequency (39.74%) of normal/ c.14_15insC genotype was appeared in Bashkirs. Association analysis of CYP2F1 geneinsertion variant with chronic obstructive pulmonary disease have shown high frequency (87.5%) of normal allele in Tatars patients with very severe stage and manifestation of chronic obstructive pulmonary disease after 55 years (chi2 = 3.964, df=1, P = 0.046; OR = = 2.268). It was shown that allele and genotype frequency distribution of Leu432ValCYP1B1 gene not differed between Russian, Tatar and Bashkir ethnic groups. We did not find any association of Leu432Val CYP1B1 gene with chronic obstructive pulmonary disease.

  19. Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk. (United States)

    Shen, Ming; Hu, Yuan-Yuan; Hu, Yu-Kun; Xie, Long-Chuan; Xu, Xiao-Ming; Wu, Ming-Yue; Niu, Yu-Ming


    The associations between CYP1B1 polymorphisms and head and neck squamous cell carcinoma (HNSCC) risk have been conflicting. We therefore performed a meta-analysis to derive a more precise relationship. Six published case-control studies were collected; odds ratios (ORs) with 95% confidence interval (CI) were used to assess the association between CYP1B1 Leu432Val, Asn453Ser polymorphisms, and HNSCC risk. The Sensitivity analysis and publication bias also were performed to guarantee the statistical power. Overall, the pooled OR with 95% CIs indicated that CYP1B1 Leu432Val polymorphism was significantly related with HNSCC risk (for Val vs. Leu: OR = 1.13, 95% CI = 1.03-1.25, P = 0.014, P(heterogeneity) = 0.141; for Val/Val vs. Leu/Leu: OR = 1.30, 95% CI = 1.06-1.60, P = 0.013, P heterogeneity = 0.253; for Val/Val vs. Leu/Leu + Leu/Val: OR = 1.23, 95% CI = 1.05-1.46, P = 0.013, P(heterogeneity) = 0.456). The similar results were also been found in succeeding analysis of HWE and stratified analysis of Caucasian population. Furthermore, no significant association between CYP1B1 Asn453Ser polymorphism and HNSCC risk was found in this meta-analysis. In conclusion, our meta-analysis demonstrates that CYP1B1 Leu432Val polymorphism may be a risk factor for developing HNSCC.

  20. Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. (United States)

    Yamaguchi, Soichiro; Jha, Archana; Li, Qin; Soyombo, Abigail A; Dickinson, George D; Churamani, Dev; Brailoiu, Eugen; Patel, Sandip; Muallem, Shmuel


    NAADP is a potent second messenger that mobilizes Ca(2+) from acidic organelles such as endosomes and lysosomes. The molecular basis for Ca(2+) release by NAADP, however, is uncertain. TRP mucolipins (TRPMLs) and two-pore channels (TPCs) are Ca(2+)-permeable ion channels present within the endolysosomal system. Both have been proposed as targets for NAADP. In the present study, we probed possible physical and functional association of these ion channels. Exogenously expressed TRPML1 showed near complete colocalization with TPC2 and partial colocalization with TPC1. TRPML3 overlap with TPC2 was more modest. TRPML1 and to some extent TRPML3 co-immunoprecipitated with TPC2 but less so with TPC1. Current recording, however, showed that TPC1 and TPC2 did not affect the activity of wild-type TRPML1 or constitutively active TRPML1(V432P). N-terminally truncated TPC2 (TPC2delN), which is targeted to the plasma membrane, also failed to affect TRPML1 and TRPML1(V432P) channel function or TRPML1(V432P)-mediated Ca(2+) influx. Whereas overexpression of TPCs enhanced NAADP-mediated Ca(2+) signals, overexpression of TRPML1 did not, and the dominant negative TRPML1(D471K) was without affect on endogenous NAADP-mediated Ca(2+) signals. Furthermore, the single channel properties of NAADP-activated TPC2delN were not affected by TRPML1. Finally, NAADP-evoked Ca(2+) oscillations in pancreatic acinar cells were identical in wild-type and TRPML1(-/-) cells. We conclude that although TRPML1 and TPCs are present in the same complex, they function as two independent organellar ion channels and that TPCs, not TRPMLs, are the targets for NAADP.

  1. A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia. (United States)

    Sun, Xin-yang; Zhang, Jin; Niu, Wei; Guo, Wei; Song, Hong-tao; Li, Heng-yu; Fan, Hui-min; Zhao, Lin; Zhong, Ai-fang; Dai, Yun-hua; Guo, Zhong-min; Zhang, Li-yi; Lu, Jim; Zhang, Qiao-li


    MicroRNAs (miRNA, miR) have been implicated as promising blood-based biomarkers for schizophrenia patients. This study aimed to clinically validate miRNA as potential schizophrenia biomarkers. Plasma levels of 10 miRNAs were analyzed using qPCR in a cohort of 61 schizophrenia patients and 62 normal controls, as well as 25 patients particularly selected for a six-week antipsychotic treatment course. Positive And Negative Syndrome Scale (PANSS), Global Assessment Scale (GAS) and Clinical Global Impression (CGI) were administered to assess the clinical symptoms. The results demonstrated that a panel of miRNAs consisting of miR-30e, miR-181b, miR-34a, miR-346 and miR-7 had significantly increased expression levels with significant combined diagnostic value (AUC:0.713; sensitivity:35.5%; specificity:90.2%). In response to pharmacological treatment, expression levels of miR-132, miR-181b, miR-432 and miR-30e were significantly decreased. In addition, the improvement of clinical symptomatology was significantly correlated with the changes of miR-132, miR-181b, miR-212 and miR-30e expression levels. Furthermore, the decreases of plasma levels of miR-132 and miR-432 were significantly greater in high-effect subgroup than those in low-effect subgroup after six-week treatment course. We conclude that miR-30e, miR-181b, miR-34a, miR-346 and miR-7 combined as a panel are potentially useful non-invasive biomarkers for schizophrenia diagnosis. Markers miR-132, miR-181b, miR-30e and miR-432 are potential indicators for symptomatology improvements, treatment responses and prognosis for schizophrenia patients.

  2. Revised $\\alpha^4$ term of lepton $g-2$ from the Feynman diagrams containing an internal light-by-light scattering subdiagram

    CERN Document Server

    Kinoshita, T


    The $\\alpha^4$ contribution to the lepton $g-2$ from a gauge-invariant set of 18 Feynman diagrams containing a light-by-light scattering subdiagram internally has been reevaluated by a method independent of the previous approach. Comparison of two methods revealed a program error in the first version. Correcting this error, the contributions of these 18 diagrams become -0.990 72 (10)$(\\alpha/\\pi)^4$ and -4.432 43 (58)$(\\alpha/\\pi)^4$ for the electron and muon $g-2$, respectively.

  3. Research and Development in Natural Language Understanding as Part of the Strategic Computing Program. Volume 3. A Guide to IRUS-II Application Development. Revision. (United States)


    Section 26 4.2.1 Variable Binding List 26 4.2.2 [Rule Body 27 4.2.3 IRule Examples 28 4.3 Creating !Rules 30 4.3.1 Using IRACQ 30 4.3.2 An IRACQ session...representing a user’s input) i; addition contains fields for the parse tree, WML, discourse entities, and anaphor resolution information for that input...more than one possible referent is found for an anaphor , the options are presented to the user, who indicates which to use. 2.2 IRUS-II Capabilities

  4. Domain Modeling: NP_055507.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_055507.1 chr16 CRAL/TRIO domain d1olme3 chr16/NP_055507.1/NP_055507.1_holo_306-497.pdb blast 314Y,331L,...333L,336M,338T,341L,354V,383L,385L,388L,392H,393L,397G,398V,400A,401L,404M,408V,416L,419L,428F,431L,432W,435I,439I,443T,447F VTQ 0 ...

  5. Domain Modeling: NP_002994.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_002994.2 chr17 CRAL/TRIO domain d1olme3 chr17/NP_002994.2/NP_002994.2_holo_319-506.pdb blast 327Y,344L,...346L,349M,351T,363L,367V,396V,398L,401L,405H,406L,410G,411V,413A,414L,417I,418I,421V,429L,432L,441F,444L,445W,448V,452I,456T,460F VTQ 0 ...

  6. Management of Contaminants Stored in Low Permeability Zones - A State of the Science Review (United States)


    66   4.3.2       Microbial  Presence  and  Contaminant   Biodegradation  in  Low  k  Units  ............................  67...implied heterogeneity • Real time data • Functions well in low k zones • Applicable to multiple NAPL types (assuming PAH present as co...Presence  and  Contaminant   Biodegradation  in  Low  k  Units   In general, groundwater samples should not be expected to be

  7. Enhancement of the superconducting critical temperature in Nb/Py/Nb trilayers

    Energy Technology Data Exchange (ETDEWEB)

    Ilyina, E.A., E-mail: [CNR-SPIN Salerno, Dipartimento di Fisica ' E.R. Caianiello' , Universita degli Studi di Salerno, Via Ponte don Melillo, Fisciano I-84084 (Italy); Hernandez, J.M.; Garcia-Santiago, A. [Departament de Fisica Fonamental, Facultat de Fisica, Universitat de Barcelona, Avinguda Diagonal 645, ES-08028 Barcelona (Spain); Institut de Nanociencia i Nanotecnologia IN2UB, Universitat de Barcelona, c. Marti i Franques 1, ES-08028 Barcelona (Spain); Cirillo, C.; Attanasio, C. [CNR-SPIN Salerno, Dipartimento di Fisica ' E.R. Caianiello' , Universita degli Studi di Salerno, Via Ponte don Melillo, Fisciano I-84084 (Italy)


    Superconducting critical temperature, T{sub c}, have been measured in a series of Nb/Py/Nb (here Py = Ni{sub 80}Fe{sub 20}) trilayers having constant Py thickness, d{sub Py} = 432 nm, and variable Nb thickness, d{sub Nb}, in the range 20-30 nm. We have observed that, for d{sub Nb} between 23 and 27 nm, resistive transitions shift towards higher temperature if stripe domains are present in the Py layer. We relate those observations to the non-homogeneous magnetization in the Py layer due to the presence of stripe domain structures.

  8. Controle de plantas daninhas na cultura do milho (Zea mays L. por meio de herbicidas Weed control in maize (Zea mays L. with herbicides

    Directory of Open Access Journals (Sweden)

    C. A. L. dos Santos


    Full Text Available Com o objetivo de se verificar a ação do butylate, aplicado isoladamente e em mistura com atrazine, no controle de plantas daninhas da cultura do milho, foi instalado um experimento de campo em solo fino areno-argiloso. Foram utilizados os seguintes tratamentos: butylate a 2,80; 3,60 e 4,32 kg/ha (p.p.i.; butylate + atrazine a 3,24 + 0,80; 3,24 + 1,20 e 3,60 + 0,96 kg/ha (p.p.i.; atrazine a 3,00 kg/ha e atrazine + metolachlor a 1,40 + 2,10 kg/ha, ambos aplicados em pré-emergência e empregados como herbicidas padrão para a cultura. As plantas daninhas encontradas foram: tiririca - Cyperus rotundus L., carurú comum - .:maranthus viridis L., capim de colchão - Digitaria sanguinalis (L. Scop. e capim pé-de-galinha Eleusine indica (L. Gaertn. Butylate nas três doses apresentou-se bem contra C. rotundus e E. indica; nas doses de 3,60 e 4,32 kg foram obtidos bons resultados sobre D. sanguinalis. Butylate + atrazine controlou, nas três doses, todas as espécies incidentes, o mesmo ocorrendo com a mistura atrazine + metolachlor. Atrazine foi mais eficiente para A. viridis e E. indica. Nas condições em que foi conduzido o experimento nenhum dos herbicidas foi prejudicial para a cultura.Butylate at 2.80; 3.60 and 4.32 kg/ha and butylate + atrazine at. 3.24 + 0.80; 3.24 + 1.20 and 3.60 + 0.96 kg, were applied in preplant incorporated; atrazine at 3.00 kg and atrazine + metolachlor at 1.40 + 2.10 kg were applied in preemergence on corn. The weeds were represented by Cyperus rotundus L., Amaranthus viridis L., Digitaria sanguinalis (L. Scop. and Eleusine indica (L. Gaertn. Butylate + atrazine, in all rates, atrazine + metolachlor and atrazine gave good control of the weeds in general. Butylate, in the three rates, controlled C. rotundus and E. indica; at 3.60 and 4.32 kg/ha controlled well D. sanguinalis. The herbicides did not cause injuries to the crop.

  9. Morvan syndrome: After scrotal sac drainage and chemical instillation in hydrocele

    Directory of Open Access Journals (Sweden)

    Sanjay Sharma


    Full Text Available We have described the occurrence of Morvan syndrome (MoS after scrotal tap and injection of sclerosing agent for the treatment of hydrocele in 5 male. The mean age was 43.2 years, and the gap between the procedure and development of clinical features suggestive of MoS was 1.5-3 months. The neurophysiology studies demonstrated hyper excitability of peripheral nerves. In addition, autonomic dysfunction, severe insomnia, and neuropsychiatric features were observed. Significant VGKC-complex/CASPR-2 antibodies titer were present in all cases. Symptoms resolved spontaneously within 6 months of onset.

  10. Platelet-Derived Growth Factor-BB Stimulates Fibronectin Gene Expression in Fibroblasts Isolated from Rat Thoracic Aorta (United States)


    immunoreactive binding proteins for IGF-I in human amniotic fluid: Relationship to fetal maturity. J. Clin. Endocrino !. Metab. 65(3): 423-43 I. Baxter... Endocrino !. Metab. 65: 432-440. Berk, B.C., Alexander, R.W., Brock, T,A., Gilbone, RC., and Webb, RC. (1986) Vasoconstriction a new activity of... Endocrino !. 2(5): 401-411. Liau, G., and Chan, L.M. (1989) Regulation of extracellular matrix RNA levels in cultured smooth muscle ceUs. Relationship to

  11. Long-term follow-up of cognitive outcome after breech presentation at birth

    DEFF Research Database (Denmark)

    Sørensen, Henrik Toft; Steffensen, Flemming Hald; Olsen, Jørn;


    with the Boerge Prien IQ test. A total of 164 conscripts were born in breech presentation and 70 (42.7%) of these were delivered after Caesarean section. The mean Boerge Prien test score was 43.2 among men born in cephalic presentation and 39.9 among those born in breech presentation for a difference of 3.3 (95......% confidence interval = 1.8-4.7). The negative association between breech presentation and cognitive outcome persisted after stratifying by Caesarean section and after adjustment for confounders. It also persisted when we restricted the analyses to term singleton pregnancies....

  12. Sea-Water Magnetohydrodynamic Propulsion for Next-Generation Undersea Vehicles (United States)


    1961. 2 J. B. Friauf, "Electromagnetic Ship Propulsion ," J. of Amer. Soc. of Naval Engrs., Feb., 1961, pp 139-142. 3 0. M. Phillips, "The Prospects for...Magnetohydrodynamic Ship Propulsion ," J. of Ship Research, March, 1962, pp 43-51. 4 R. A. Doragh, "Magnetohydrodynamic Ship Propulsion using...Paper # 67-432. I A. P. Baranov, "Future of Magnetohydrodynamic Ship Propulsion ," Sudostroyeniye, No. 12, 1966, pp 3-6. 8 A. Iwata, Y. Saji and S. Sato

  13. The fatty acid and cholesterol composition of enriched egg yolk lipids obtained by modifying hens’ diets with fish oil and flaxseed

    Directory of Open Access Journals (Sweden)

    Yalçyn, Hasan


    Full Text Available The effects of fish oil and flaxseed in the diets of laying hens on the cholesterol and fatty acid composition of egg lipids were studied. Isa-White laying hens and five experimental diets were used. The first diet was used as the control. Fish oil (1.5%, flaxseed (4.32% and 8.64 or both of them (1.5% fish oil and 4.32% flaxseed were added to the others and hens were fed for 30 and 60 days. The cholesterol and fatty acid composition of the yolks were determined. No significant difference (pSe han estudiado los efectos producidos por la presencia de aceite de pescado y linaza, en la dieta de gallinas ponedoras, sobre la composición en colesterol y ácidos grasos de los lípidos del huevo. Se han utilizado gallinas ponedoras Isa-White y cinco tipos de dietas experimentales. La primera dieta fue usada como control. Se añadió aceite de pescado (1.5%, linaza (4.32% y 8.64 o ambos (1.5% aceite de pescado y 4.32% linaza a las otras dietas y se alimentó a las gallinas durante 30 y 60 días, determinándose la composición en colesterol y ácidos grasos de las yemas. No se encontró diferencia significativa (p<0.05 debida a las dietas en el contenido de colesterol de las yemas excepto en la que contenía 8.64% de linaza. El contenido total de ácidos grasos saturados disminuyó en todas las dietas en comparación con la dieta control. El contenido total de ácidos grasos n-3 fue significativamente mayor en todas las dietas. El cambio predominante en las dietas que contenían linaza se encontró en el contenido de ácido linolénico. El contenido de los ácidos eicosapentaenoico, docosapentaenoico y docosahexaenoico de todas las dietas fue significativamente mayor.

  14. VizieR Online Data Catalog: Berkeley supernova Ia program. II. (Silverman+, 2012) (United States)

    Silverman, J. M.; Kong, J. J.; Filippenko, A. V.


    In this second paper in a series, we present measurements of spectral features of 432 low-redshift (zSilverman et al. (J/MNRAS/425/1789). We describe in detail our method of automated, robust spectral feature definition and measurement which expands upon similar previous studies. Using this procedure, we attempt to measure expansion velocities, pseudo-equivalent widths (pEWs), spectral feature depths and fluxes at the centre and endpoints of each of nine major spectral feature complexes. (10 data files).

  15. Design of a Film Cooling Experiment for Rocket Engines (United States)


    Mar It) Date iv AFIT/GAE...line was tested Coolant Hole Diameters Co ola nt Ho le Dia me ter s 1 2 3 4 5 6 7 8 9 10 11 12 13 14 1 2 3 4 5 6 438 440 442 444 446 448 450 452...Coolant Hole Diameters Co ola nt Ho le Di am ete rs 1 2 3 4 5 6 7 8 9 10 11 12 13 14 1 2 3 4 5 428 430 432 434 436 438 440 442 444 446 448 450

  16. Acidentes de trabalho afetando a coluna vertebral: um estudo realizado com trabalhadores de enfermagem de um hospital universitário Los accidentes de trabajo que afectan la columna vertebral: un estudio realizado con trabajadores de enfermeria de un hospital universitario Occupational accidents affecting the spinal vertebrae: a study among nursing workers of a university hospital


    Neusa Maria Costa Alexandre; Maria Cecília Cardoso Benatti


    Com o objetivo de avaliar determinadas características da ocorrência de acidentes do trabalho afetando a coluna vertebral em trabalhadores de enfermagem de um hospital universitário, entrevistou-se todos os funcionários que sofreram esse tipo de acidente em um período de seis meses. Esses trabalhadores eram basicamente do sexo feminino e tinham uma idade média de 43,2 anos. Não houve uma diferença estatística significante que demonstrasse um predomínio de acidentes entre os turnos de trabalho...

  17. Angular Momentum Population in Projectile Fragmentation (United States)

    Podolyák, Zs.; Gladnishki, K. A.; Gerl, J.; Hellström, M.; Kopatch, Y.; Mandal, S.; Górska, M.; Regan, P. H.; Wollersheim, H. J.; Schmidt, K.-H.; Gsi-Isomer Collaboration


    Isomeric states in neutron-deficient nuclei around A ≈190 have been identified following the projectile fragmentation of a relativistic energy 238U beam. The deduced isomeric ratios are compared with a model based on the abrasion-ablation description. The experimental isomeric ratios are lower by a factor of ≈2 than the calculated ones assuming the `sharp cutoff' approximation. The observation of the previously reported isomeric Iπ=43/2- state in 215Ra represents the current record for the highest discrete spin state observed following a projectile fragmentation reaction.

  18. Quantitative correlation of aflatoxin biomarker with dietary intake of aflatoxin in Tanzanian children. (United States)

    Routledge, Michael N; Kimanya, Martin E; Shirima, Candida P; Wild, Christopher P; Gong, Yun Yun


    The association between aflatoxin intake from maize-based weaning food and aflatoxin albumin adducts (AF-alb) was investigated in 148 Tanzanian children aged between 12 and 22 months, at 2 visits 6 months apart. At the first visit (storage season) there was a significant correlation at the individual level between AF-alb (geometric mean 43.2 pg/mg albumin) and aflatoxin intake (geometric mean 81.7 ng/kg b.w./d) through maize-based weaning food (r = 0.51, p aflatoxin intake from maize in weaning food. Exposure levels suggest children may be at risk from aflatoxin associated health effects.

  19. 黑色风暴——三星SE-S164外置DVD刻录机

    Institute of Scientific and Technical Information of China (English)




  20. Study of Curing Processing of Epoxy Resin in VARTM%VARTM用环氧树脂固化工艺的研究

    Institute of Scientific and Technical Information of China (English)



    对3种配方的真空辅助传递模塑(vARTM)工艺用环氧树脂,采用动态升温DSC实验,升温速率分别为5、10和15℃/min,引入Kissinger理论,确定了树脂体系的表观活化能分别为4.32kJ/mol、5.57 kJ/mol和3.49 kJ/mol;利用外推法,确定了参考固化工艺温度.




    A study was conducted on level of adoption and constraints of backyard poultry rearing practices in rural tribal areas of Sikkim. The data were collected from 125 respondents of Dzongu area, North Sikkim through personal interview with the help of questionnaire. From the present study it was found that 64.8% respondents were medium level adopters followed by high level (19.2%) and low level (16%) adopters. Housing (43.2%) were highly adopted followed by feeding and watering (41.6%), marketing...

  2. Isolation of polymorphic microsatellite loci for the marine invader Microcosmus squamiger (Ascidiacea). (United States)

    Rius, Marc; Turon, Xavier; Pascual, Marta


    The ascidian Microcosmus squamiger is native to Australia and has recently spread worldwide. It has become a pest in some littoral communities within its introduced range. An enriched genomic library of M. squamiger resulted in a total of eight polymorphic loci that were genotyped in 20 individuals from a population within its introduced range, and 20 individuals more from a native population. The mean number of alleles per locus was 5.33 and mean observed heterozygosity was 0.432. No significant linkage disequilibrium was found among loci pairs. Significant genetic differentiation was observed between populations.

  3. Integrating Methodologists into Teams of Substantive Experts (United States)


    Press, 199i) 59 Expert Teams actuarial predictions, for example, they tend to score as well as the statistical model if they use the sta tistical...Model of Man A Rationale, Plus some Evidence, for a Method of improving on clinical tnfereoc Cs,� Pssr.holag,eal Bulletin, Vol 73, 1970. pp 422-432...behavioi�. One hope is that neither c� xpert treats the data set as an anomaly. that both repcii�t it as significant. Another hope is that each expert�s

  4. Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females

    DEFF Research Database (Denmark)

    Laska, Magdalena Janina; Troldborg, Anne; Hansen, Bettina;


    and to determine the expression of various TLRs in peripheral blood mononuclear cells (PBMCs) of patients with SLE. METHODS: The TLR polymorphisms in a cohort of 143 Danish lupus patients and 432 healthy Danish blood donors were analysed. Groups were age matched. Genotyping for the TLR single......: These results obtained from a female lupus population of Danish ancestry suggest that variations in TLR3, TLR8 and TLR9 genes are implicated in the pathogenesis of the disease. If these polymorphisms are associated with innate immune dysfunction they may add to the growing field of theoretically well founded...

  5. IEEE Life Cycle Standards and the CMMI(Trademark) - Implementation Considerations (United States)


    Maloney CH 1l43{) R. N. Haddad M5-689 D. C. Marvin M I-003 L. F. Halle CHI-530 L. S. Marvin M6-2W4 P. Hantos Ml-1 12 J. F. McNeil MI-178 FINAL...M4-021 R. P. Sena M5-688 H. M. Shao M8-691 B. E. Shaw M5-564 I. S. Shrater M3-432 F. J. Sisti M8-018 D. M. Speckamn M 1-003 B . Springsteen CH 1-402

  6. AcEST: BP915568 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ... 32 1.8 sp|Q4ADK7|CFDP1_CAMDR Craniofacial development protein 1 OS=Came... 30 5.2 sp|P70390|SHOX2_MOUSE ...B2_ORYSJ Glutelin type-B 2 OS=Oryza sativa subsp. j... 30 8.8 sp|Q60FC2|CFDP1_TRAJA Craniofacial... 239 RSS + +RE+I Sbjct: 428 ----RSSSLSKIRESI 439 >sp|Q4ADK7|CFDP1_CAMDR Craniofacial...IS+E + + H A Sbjct: 432 HLAGKNSVFRALPVDVVANAYRISREQARSIKNNRGEEHGA 472 >sp|Q60FC2|CFDP1_TRAJA Craniofacial de

  7. Comparison of pain, kinesiophobia and quality of life in patients with low back and neck pain


    Uluğ, Naime; Yakut, Yavuz; Alemdaroğlu, İpek; Yılmaz, Öznur


    [Purpose] The purpose of this study was to compare patients with low back and neck pain with respect to kinesiophobia, pain, and quality of life. [Subjects and Methods] Three-hundred patients with low back (mean age 43.2±11 years) and 300 with neck pain (mean age 42.8±10.2 years) were included in this study. Pain severity was evaluated by using the Short-Form McGill Pain Questionnaire, which includes a Visual Analogue Scale, quality of life by the Nottingham Health Profile, and kinesiophobia ...

  8. Crosstalk between mTORC1 and cAMP Signaling (United States)


    Leucine and Glutamine. Science 347, 194-198. 4. Jewell, J.L., Flores, F., and Guan, K-L. (2015) Micro ( RNA ) managing by mTORC1. Mol. Cell 57, 575-6. 5...Glycoholics anonymous: Cancer sobers up with mTORC1. Cancer Cell 29, 432-434. 8. Jewell, J.L., Flores, F., and Guan, K-L. (2015) Micro ( RNA ) managing by...Rapamycin or were depleted of the mTORC1 subunit Raptor with short hairpin RNA (shRNA) (fig. S3). Thus, mTORC1 is active in the absence of RagA and

  9. Fortune Cookie Sand Dunes (United States)


    MGS MOC Release No. MOC2-432, 25 July 2003This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a field of small barchan sand dunes in the north polar region near 71.7oN, 51.3oW. Some of them are shaped like fortune cookies. The message these dunes provide: winds blow through this region from the lower right toward the upper left. The steep slip face slopes of these dunes, which point toward the upper left, indicate the wind direction. The scene is illuminated by sunlight from the upper right. The image is 3 km (1.9 mi) wide.

  10. 76 FR 36486 - Preliminary Theft Data; Motor Vehicle Theft Prevention Standard (United States)


    ... FORD MOTOR CO SHELBY GT 5 581 8.6059 3 BMW M5 2 264 7.5758 4 CHRYSLER DODGE CHARGER 432 66,856 6.4616 5.......... 53 20,526 2.5821 22 NISSAN PATHFINDER 13 5,076 2.5611 23 BMW M6 1 397 2.5189 24 CHRYSLER DODGE NITRO............ CHEVROLET TRAILBLAZER.. 22 13,022 1.6894 54 TOYOTA 4RUNNER 13 7,803 1.6660 55 BMW 6 4 2,420 1.6529...

  11. Network Science Experimentation Vision (United States)


    Experimentation Ecosystem 3 2.1 Multi-thread Campaign of Experimentation 4 2.1.1 Need for a CAMPX 4 2.1.2 CAMPX Overview 5 2.1.3 Conceptual Model ...Collaborative Research Alliance (CS CRA) and Applied Research and Experimentation Partner (AREP) Programs 19 3.3 Researcher Empowerment and...Productivity 20 4. Composite Network CAMPX 21 4.1 Military Relevance 21 iv 4.2 Goals 22 4.3 Conceptual Model 23 4.3.1 Endeavor Space 23 4.3.2 Single

  12. 兰州多普勒雷达功率测量

    Institute of Scientific and Technical Information of China (English)



    一、引言为促进对多普勒天气雷达的认识和了解,加强对多普勒天气雷达的维护,本文就Agilent E4416A单通道峰值功率计和HP432A单通道平均功率计,对兰州DWSR2500C多普勒天气雷达的功率进行分析与测试。

  13. Experiencia en hernioplastía inguinal con anestesia local.


    Aliaga Chávez, Noél


    Objetivo: Evaluar la utilidad de la cirugía ambulatoria con anestesia local en pacientes con patología herniaria inguinal. Material y métodos: Se realizó un estudio descriptivo tipo serie de casos, entre abril de 1996 y marzo de 1999, en el Servicio de Cirugía de la Clínica Fiori. Se intervinieron 1,167 pacientes por patología de pared abdominal, de las cuales 432 correspondieron a pacientes intervenidos por patología herniaria inguinal, de ellos 372 fueron operados con anestesia local, los c...

  14. The Power to Raise and Support Armies: The Homosexual Exclusion Policy in Perspective (United States)


    Living Center, 473 U.S. 432, 440-41 (1985); Massachussetts Bd. of Retirement v. Murgia, 427 U.S. 307, 313 (1976); San Antonio School Dist. v. Rodriguez ...Antonio Indep. School Dist. v. Rodriguez , 411 U.S. 1 (1973). In Rodriguez , 204 the Court found that even if some quantum of education was...e.g., Johnson v. San Jacinto Jr. College, 498 F. Supp. 555, 575 (S.D. Tex. 1980) and Wilson v. Swing, 463 F. Supp. 555 (M.D.N.C. 1978) (extra-marital

  15. Interaction of different irrigation strategies and soil textures on the nitrogen uptake of field grown potatoes

    DEFF Research Database (Denmark)

    Ahmadi, S.H.; Andersen, M.N.; Lærke, P.E.;


    Nitrogen (N) uptake (kg ha-1) of field-grown potatoes was measured in 4.32 m2 lysimeters that were filled with coarse sand, loamy sand, and sandy loam and subjected to full (FI), deficit (DI), and partial root-zone drying (PRD) irrigation strategies. PRD and DI as water-saving irrigation treatments...... received 65% of FI after tuber bulking and lasted for six weeks until final harvest. Results showed that the irrigation treatments were not significantly different in terms of N uptake in the tubers, shoot, and whole crop. However, there was a statistical difference between the soil textures where plants...

  16. Effects of irrigation strategies and soils on field grown potatoes

    DEFF Research Database (Denmark)

    Ahmadi, Seyed Hamid; Plauborg, Finn; Andersen, Mathias Neumann;


    Root distribution of field grown potatoes (cv. Folva) was studied in 4.32m2 lysimeters and subjected to full (FI), deficit (DI), and partial root-zone drying (PRD) irrigation strategies. Drip irrigation was applied for all irrigations. Irrigations were run in three different soils: coarse sand......, loamy sand, and sandy loam. Irrigation treatments started after tuber bulking and lasted until final harvest with PRD and DI receiving 65% of FI. Potatoes irrigated with water-saving irrigation techniques (PRD and DI) did not show statistically different dry root mass and root length density (RLD, cm...... in practice for efficient use of water and nutrients in the field....

  17. Designer-Driven Topology Optimization for Pipelined Analog to Digital Converters

    CERN Document Server

    Chien, Yu-Tsun; Lou, Jea-Hong; Ma, Gin-Kou; Rutenbar, Rob A; Mukherjee, Tamal


    This paper suggests a practical "hybrid" synthesis methodology which integrates designer-derived analytical models for system-level description with simulation-based models at the circuit level. We show how to optimize stage-resolution to minimize the power in a pipelined ADC. Exploration (via detailed synthesis) of several ADC configurations is used to show that a 4-3-2... resolution distribution uses the least power for a 13-bit 40 MSPS converter in a 0.25 $\\mu$m CMOS process.

  18. Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism.


    Inhorn, R C; Bansal, V S; Majerus, P W


    We prepared [3H]inositol-,3-[32P]phosphate-and 4-[32P]phosphate-labeled inositol phosphate substrates to investigate the metabolism of inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. In crude extracts of calf brain, inositol 1,3,4-trisphosphate is first converted to inositol 3,4-bisphosphate, then the inositol 3,4-bisphosphate intermediate is further converted to inositol 3-phosphate. Similarly, inositol 1,4-bisphosphate is converted to inositol 4-phosphate, and no inositol 1-phos...

  19. Optimization of engineered production of the glucoraphanin precursor dihomomethionine in Nicotiana benthamiana

    DEFF Research Database (Denmark)

    Crocoll, Christoph; Mirza, Nadia Muhammad Akram; Reichelt, Michael;


    of the large subunit (LSU1) of the heterodimeric isopropylmalate isomerase and (2) coexpression of BAT5 transporter for efficient transfer of intermediates across the chloroplast membrane. We succeeded in raising dihomomethionine (DHM) levels to a maximum of 432 nmol g(-1) fresh weight that is equivalent...... to a ninefold increase compared to the highest production of this intermediate, as previously reported (Mikkelsen et al., 2010). The increased DHM production without increasing leucine-derived side-product levels provides new metabolic engineering strategies for improved glucoraphanin production...

  20. 气相色谱-质谱法检测桑叶中的农药残留

    Institute of Scientific and Technical Information of China (English)

    秦曙; 乔雄梧; 王霞; 周华


    pesticide residues in mulberry leaf that can lead to silkworm poisoning, was analysed. The mulberry leaf was extracted with acetone, cleaned up by gel permeation chromatography and a small silica gel column, and finally detected by gas chrornatography-mass spectrometry (GC/MS) and GC/ECD. There was 0. 432mg/kg eypermethrin in mulberry leaf(dry weight), and 2.14% cypermethrin in a formulation of dichlorvos 80EC used by the insect pest control of mulberry tree. The results gives a satisfactory explaination of the case silkworm poisoning, as cypermethrin is high toxic to silkworm and is banned pesticide in pest control by mulberry tree.

  1. Antizyme 1 Gene is Associated with Loin Muscle Area and Marbling in Landrace × Lantang F2 Resource Population

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hao; WU Xue-yan; LIU De-wu; WU Zhen-fang; WANG Chong; CHEN Yao-sheng; LI Jia-qi


    The expression level of antizyme 1 (AZ1) gene in Longissimus dorsi muscle of Landrace pigs is significantly higher than that of Lantang pigs based on our previous studies. The AZ1 is a key regulator of the concentration of polyamines in cells. It is a good candidate gene for pig's performance because polyamines regulate the growth and development of cells. Four PCR-RFLPs were selected to study the relation between AZ1 genotypes and porcine performance. Results showed that the loci of-713 C/T, -584 A/C, and +2 432 G/A had significant or highly significant opposite effects on loin muscle area and marbling.

  2. When Adolescents with High Self-Concept Lose their Engagement in School


    Veiga, Feliciano; García, Fernando; Reeve, Johnmarshall; Wentzel, Kathryn; García, Óscar


    La motivación escolar y el autoconcepto son dos constructos claves del ajuste académico. Para entender cómo la motivación escolar cambia durante la adolescencia, se analizó la motivación académica de adolescentes tempranos y medios (cognitiva, afectiva, conductual e implicación personal) y su autoconcepto. La muestra fue de 685 adolescentes, 296 hombres (43,2%) y 389 mujeres de 11 a 17 años. Los adolescentes tempranos con alto autoconcepto siempre indicaron mayor motivación cognit...

  3. Control Coordination of Large Scale Hereditary Systems. (United States)


    SIAM J. Contr. Opt., 16 (1978), 599-645. [8] A. N. Michel , On the status of stability of interconnected systems, IEEE Trans. Automat. Contr. AC-28...Salamon, On controllability and observability of time delay systems, IEEE Trans Automat. Contr., AC-29 (1984), 432-438. [14] N. R. Sandell , P. Varaiya...John Wiley and Sons, New York, hi(T)-b I and h2 (T)-b 2 with limited information 1980." exchanged between components. (2) N. R. Sandell , P. Varaiya, M

  4. Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair. (United States)

    Harth, Volker; Schafer, Martin; Abel, Josef; Maintz, Laura; Neuhaus, Thomas; Besuden, Mette; Primke, Robert; Wilkesmann, Anja; Thier, Ricarda; Vetter, Hans; Ko, Yon-Dschun; Bruning, Thomas; Bolt, Hermann M; Ickstadt, Katja


    Tobacco smoking, alcohol drinking, and occupational exposures to polycyclic aromatic hydrocarbons are the major proven risk factors for human head and neck squamous-cell cancer (HNSCC). Major research focus on gene-environment interactions concerning HNSCC has been on genes encoding enzymes of metabolism for tobacco smoke constituents and repair enzymes. To investigate the role of genetically determined individual predispositions in enzymes of xenobiotic metabolism and in repair enzymes under the exogenous risk factor tobacco smoke in the carcinogenesis of HNSCC, we conducted a case-control study on 312 cases and 300 noncancer controls. We focused on the impact of 22 sequence variations in CYP1A1, CYP1B1, CYP2E1, ERCC2/XPD, GSTM1, GSTP1, GSTT1, NAT2, NQO1, and XRCC1. To assess relevant main and interactive effects of polymorphic genes on the susceptibility to HNSCC we used statistical models such as logic regression and a Bayesian version of logic regression. In subgroup analysis of nonsmokers, main effects in ERCC2 (Lys751Gln) C/C genotype and combined ERCC2 (Arg156Arg) C/A and A/A genotypes were predominant. When stratifying for smokers, the data revealed main effects on combined CYP1B1 (Leu432Val) C/G and G/G genotypes, followed by CYP1B1 (Leu432Val) G/G genotype and CYP2E1 (-70G>T) G/T genotype. When fitting logistic regression models including relevant main effects and interactions in smokers, we found relevant associations of CYP1B1 (Leu432Val) C/G genotype and CYP2E1 (-70G>T) G/T genotype (OR, 10.84; 95% CI, 1.64-71.53) as well as CYP1B1 (Leu432Val) G/G genotype and GSTM1 null/null genotype (OR, 11.79; 95% CI, 2.18-63.77) with HNSCC. The findings underline the relevance of genotypes of polymorphic CYP1B1 combined with exposures to tobacco smoke.

  5. Ageing studies on CuInS2/In2S3 junction (2.5×2cm2) deposited using automated spray machine (United States)

    Santhosh, M. V.; Kartha, C. Sudha; Vijayakumar, K. P.


    CuInS2/In2S3 heterojunction photovoltaic device was realized in an area of 2.5 × 2 cm2 using automated spray pyrolysis machine which shows an open-circuit voltage of 432mV, short circuit current density of 6.33mA/cm2, fill factor of 34% and efficiency of 0.94%. Performance of the device was monitored up to 100 days and it was working quite well without the application of any protective coatings. The device maintains a fill factor of around 32% up to 80 days but other photovoltaic parameters had slight decrease.

  6. Nondestructive Evaluation (NDE) Technology Initiatives (NTIP). Delivery Order 0039: Statistical Comparison of Competing Material Models (United States)


    Siddhartha Chib, “Bayesian Model Choice via Markov Chain Monte Carlo Methods,” Journal of the Royal Society B Vol. 57, No. 3 pp 173-484, 1995 11) Carlin...34Explaining the Gibbs Sampler," The American Statistician, 46, 167-174, 1992 Appendix I Page 54 of 57 13) Chib, Siddhartha , “Marginal Likelihood...from the Gibbs Output” Journal of the American Statistical Association, Vol. 90, No. 432. (Dec., 1995), pp. 1313-1321. 14) Chib, Siddhartha , “Bayesian

  7. A high-throughput method for genotyping S-RNase alleles in apple

    DEFF Research Database (Denmark)

    Larsen, Bjarne; Ørgaard, Marian; Toldam-Andersen, Torben Bo


    We present a new efficient screening tool for detection of S-alleles in apple. The protocol using general and multiplexed primers for PCR reaction and fragment detection on an automatized capillary DNA sequencer exposed a higher number of alleles than any previous studies. Analysis of alleles...... is made on basis of three individual fragment sizes making the allele interpretation highly accurate. The method was employed to genotype 432 Malus accessions and exposed 25 different S-alleles in a selection of Malus domestica cultivars of mainly Danish origin (402 accessions) as well as a selection...

  8. Summarizing sugar cane test demonstrating by using aminophenol complex fertilizer%甘蔗施用氨基酸复合肥试验示范总结

    Institute of Scientific and Technical Information of China (English)

    张成家; 冯奕玺; 吴诗



  9. Phylogenetic characterization of bovine parainfluenza 3 from contaminated cell cultures and field isolates from Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo de Almeida Vaucher


    Full Text Available Genomic fragments of the HN and L genes from Brazilian bovine parainfluenza 3 virus (bPIV-3 isolated as contaminants from cell cultures and clinical specimens were amplified by reverse transcription-polymerase chain reaction (RT-PCR, sequenced using specific degenerate primers and analyzed by phylogenetic comparison with reference strains of bPI3V. The Brazilian isolates revealed a high degree of genomic when compared to SF4/32 prototype strain, within the recently proposed genotype A of bPIV-3.

  10. [Prevalence of dental diseases among Moscow students and need of dentistry]. (United States)

    Makeeva, I M; Doroshina, V Iu; Protsenko, A S


    A clinical epidemiologic study was made among 432 Moscow students and as a part of it was found the high prevalence rate of pathologies of dentition and variety of nosologic forms. The most common cases were: caries, periodontal disease, deformity and anomalies of tooth position. These findings were necessary to estimate the need of all types of dentistry for Moscow students. It was specified that 43% of students were in need of filling and dental restoration, 35% were in need of crowns of tooth, 22% were in need of dental restoration by means of orthopedic constructions. Endodontic dentistry was necessary for 31% of students, surgical removal - for 8%, periodontal dentistry - for 37%.

  11. [Screening of phagocyte activators in plants; enhancement of TNF production by flavonoids]. (United States)

    Kunizane, H; Ueda, H; Yamazaki, M


    The tumor necrosis factor (TNF) was first discovered as a substance that induced necrosis of transplanted tumors. Recently, TNF has been recognized as an important and endogenous mediator in host defense mechanisms. To prove the fact that plant foods contain substances which activate the host defense mechanisms, we first examined if the administration of flavonoids could induce TNF production in mice. Some selected flavonoids such as naringin, apiin, poncirin and rutin were shown to amplify TNF release from murine macrophages in vivo in response to OK-432 as a second stimulus. However, their aglycone forms were not effective. The differences in the saccharide-chain of flavonoids induced the variety of TNF production.

  12. Hyperextension of the elbow joint

    DEFF Research Database (Denmark)

    Tyrdal, Stein; Olsen, Bo Sanderhoff


    According to an epidemiologic study (Scand J Med Sci 1996/ 6: 297-302) the mechanism of "handball goalie's elbow" may be forced hyperextension. The pathomechanics of hyperextension were studied in nine macroscopically normal male cadaver elbow joints. The mean age of the donors was 43.2 years...... of the medial collateral ligament; (3) occasional incomplete rupture of the lateral collateral ligament; and (4) small fragments of cartilage near the posterior edge of the ulna in one of the specimens. One or more of these lesions may be responsible for the symptoms in "handball goalie's elbow."...

  13. Prokaryote phylogeny meets taxonomy: An exhaustive comparison of composition vector trees with systematic bacteriology

    Institute of Scientific and Technical Information of China (English)

    GAO; Lei; QI; Ji; SUN; JianDong; HAO; BaiLin


    We perform an exhaustive, taxon by taxon, comparison of the branchings in the composition vector trees (CVTrees) inferred from 432 prokaryotic genomes available on 31 December 2006, with the bacteriologists' taxonomy-primarily the latest online Outline of the Bergey's Manual of Systematic Bacteriology. The CVTree phylogeny agrees very well with the Bergey's taxonomy in majority of fine branchings and overall structures. At the same time most of the differences between the trees and the Manual have been known to biologists to some extent and may hint at taxonomic revisions. Instead of demonstrating the overwhelming agreement this paper puts emphasis on the biological implications of the differences.


    Institute of Scientific and Technical Information of China (English)


    <正>20071446 Kazue Tazaki(Graduate School of Natural Science and Technology,Kanazawa University,Kakuma,Kanazawa,Ishikawa 920-1192,Japan);Hiroaki Watanabe Hy- drocarbon-Degrading Bacteria and Paraffin from Polluted Seashores 9 Years after the Nakhodka Oil Spill in the Sea of Japan(Acta Geologica Sinica(English Edition)——Jour- nal of the Geological Society of China,ISSN 1000-9515,CN11-2001/P,80(3),2006, p.432-440,6 illus.,54 refs.,with English abstract)

  15. The co-occurrence of PTSD and dissociation: differentiating severe PTSD from dissociative-PTSD

    DEFF Research Database (Denmark)

    Armour, C.; Karstoft, K. I.; Richardson, J. D.


    -PTSD. The current study investigated the existence of a dissociative-PTSD subtype and explored whether a number of trauma and clinical covariates could differentiate between severe PTSD alone and dissociative-PTSD. The current study utilized a sample of 432 treatment seeking Canadian military veterans. Participants...... constituted a severe PTSD group (30.5 %), and one of which constituted a dissociative-PTSD group (13.7 %). None of the included, demographic, trauma, or clinical covariates were significantly predictive of membership in the dissociative-PTSD group compared to the severe PTSD group. In conclusion...

  16. Nonuniform Shear Strains in Torsional Kolsky Bar Tests on Soft Specimens (United States)


    for the ramp-up portion of the loading pulse (see [ Fitzpatrick and Scheidler 2013]): H5(x)= 10x3− 15x4+ 6x5, 0≤ x ≤ 1. (B-1) This function increases...from 0 at x = 0 to 1 at x = 1 and has zero first and second derivatives at both of these end points. Following [ Fitzpatrick and Scheidler 2013], one can...B. R. Donnelly and J. Medige, “Shear properties of human brain tissue”, J. Biomech. Eng. (ASME) 119:4 (1997), 423–432. [ Fitzpatrick and Scheidler

  17. Effects of L-NAME on morphometric parameters of stomach parietal cells in pregnant rats

    Directory of Open Access Journals (Sweden)

    Seyed Mohammad Hossein Noori Mugahi


    Results: Results of this study after analysis showed the significant changes in parietal cells count (mean 61.3±4.32 and its diameters (mean 16.12±1.18 µm in L-NAME group in comparison to control and the sham groups in pregnant rats (P≤0.05. Conclusion: Results of this study showed L-NAME with effects on NO synthesis can reduce the count of parietal cells and increase its diameter in pregnant rats and has destructive effects on structure of stomach parietal cells in pregnancy rats.

  18. Association of CYP1B1 Polymorphisms with Breast Cancer: A Case-Control Study in the Han Population in Ningxia Hui Autonomous Region, P. R. China


    Haiyan Jiao; Chunlian Liu; Weidong Guo; Liang Peng; Yintao Chen; Martin, Francis L.


    Studies investigating possible associations between cytochrome P4501B1 (CYP1B1) polymorphisms and breast cancer risk have been inconsistent. We set out to ascertain whether there might be an association between polymorphisms in exon 2 (codon 119, G→T) and exon 3 (codon 432, G→C) of CYP1B1 and breast cancer in a Chinese Han population in the rural region of Ningxia. Using an allele-specific polymerase chain reaction method and direct DNA sequencing, the presence or absence of the two CYP1B1 po...

  19. Association of Single Nucleotide Polymorphisms in CYP1B1 and COMT Genes with Breast Cancer Susceptibility in Indian Women


    Sharawan Yadav; Naveen Kumar Singhal; Virendra Singh; Neeraj Rastogi; Pramod Kumar Srivastava; Mahendra Pratap Singh


    Cytochrome P450 1B1 (CYP1B1) and catechol-$O$-methyltransferase (COMT) enzymes play critical roles in estrogen metabolism. Alterations in the catalytic activity of CYP1B1 and COMT enzymes have been found associated with altered breast cancer risk in postmenopausal women in many populations. The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of ...

  20. CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population.


    Sillanpaa, Pia; Heikinheimo, Liisa; Kataja, Vesa; Eskelinen, Matti; Kosma, Veli-Matti; Uusitupa, Matti; Vainio, Harri; Metsola, Katja; Hirvonen, Ari


    We investigated the associations between two CYP1A1 polymorphisms (Ile462Val and Thr461Asn) and one CYP1B1 polymorphism (Leu432Val) and breast cancer risk. The study population consisted of 483 breast cancer patients and 482 healthy population controls, all of homogenous Finnish origin. No statistically significant overall associations were found between the CYP1A1 and CYP1B1 genotypes and breast cancer risk. However, a significant increase in the breast cancer risk was seen for women who had...

  1. Energy and Water Conservation Assessment of the Radiochemical Processing Laboratory (RPL) at Pacific Northwest National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Stephanie R.; Koehler, Theresa M.; Boyd, Brian K.


    This report summarizes the results of an energy and water conservation assessment of the Radiochemical Processing Laboratory (RPL) at Pacific Northwest National Laboratory (PNNL). The assessment was performed in October 2013 by engineers from the PNNL Building Performance Team with the support of the dedicated RPL staff and several Facilities and Operations (F&O) department engineers. The assessment was completed for the Facilities and Operations (F&O) department at PNNL in support of the requirements within Section 432 of the Energy Independence and Security Act (EISA) of 2007.

  2. AcEST: BP914323 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000057_F04 535 Adiantum capillus-veneris mRNA. clone: YMU001_000057_F04. BP91432...3 CL2361Contig1 Show BP914323 Clone id YMU001_000057_F04 Library YMU01 Length 535 Definition Adiantum ca...pillus-veneris mRNA. clone: YMU001_000057_F04. Accession BP914323 Tissue type prothallium Developmental stag...atabase search programs, Nucleic Acids Res. 25:3389-3402. Query= BP914323|Adiantum capillus-veneris mRNA, cl...IEKGKCAFTLGNEEVGPKNGVT----SVAMSPDGRLVAA 432 Query: 182 GDSSGSTQFWDGKQGTLLQAHRGHTADVLALAAAPSHRSVFAAGADGLVVQYQ

  3. AcEST: DK959432 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 9. 5' end sequence. DK959432 - Show DK959432 Clone id TST39A01NGRL0004_K19 Library TST39 Length 659 Definiti...on Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0004_K19. 5' end sequence. Accession DK959432 Tissue t...: a new generation of protein database search programs, Nucleic Acids Res. 25:3389-3402. Query= DK959432|Adi...ST: a new generation of protein database search programs, Nucleic Acids Res. 25:3389-3402. Query= DK959432|A...H S IF +VG D LY++SEA+DVV+ Sbjct: 374 -KAEVSESPGERSTAQAQSEKGLEIIEVYKSSIHNSAIFASVGEDKGNLYTASEATDVVF 432 Query:

  4. Musik og Planter


    Jensen, Asger Lindhardt; Bro, Jonas Andersen; Bruun, Nanna Olivia Lerke; Jensen, Kasper Sternberg Brogaard; Wozniak, Martin Moltke; Larsen, Alex Nygaard


    I denne rapport undersøger vi, hvordan musik kan have en effekt på planters vækst. Rapporten indeholder teorier om processer, der er vigtige for en plantes vækst, samt to hypoteser om, hvorledes nogle af disse processer kan påvirkes. Hypoteserne bliver præsenteret og sammenlignet med anerkendte teorier. Vi har foretaget et forsøg, hvor vi spiller Vivaldis La Primavera for karse (Lepidium sativum) ved henholdsvis 432 og 440 hertz. Vi har ikke kunne påvise hvilke processer der bliver påvirke...

  5. A Uniform CO Survey of the Molecular Clouds in Orion and Monoceros

    CERN Document Server

    Wilson, B A; Masheder, M R W; Thaddeus, P


    We report the results of a new large scale survey of the Orion-Monoceros complex of molecular clouds made in the J = 1->0 line of CO with the Harvard-Smithsonian 1.2m millimetre-wave telescope. The survey consists of 52,288 uniformly spaced spectra that cover an area of 432 square degrees on the sky and is the most sensitive large-scale survey of the region to date. Distances to the constituent molecular clouds of the complex, estimated from an analysis of foreground and background stars, have provided information on the three dimensional structure of the entire complex.

  6. Results of measuring internal Ca absorption and Ca kinetics with /sup 47/Ca in patients suffering from chronically recurrent urolithiasis

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, L.; Esther, G.; Serfling, D.; Bast, R. (Rostock Univ. (German Democratic Republic). Radiologische Klinik)


    47 patients with chronically recurrent calcium lithiasis (with between 3 and over 100 stone episodes) and an average age of 43.2 years have been examined. The Ca absorption lay between 42.7% and 90.0% of the dose, the average was 59.3% with a standard deviation of +- 12.9. This is higher than in persons with healthy kidneys. The Ca absorption is significantly lower in patients with renal insufficiency. Studies on Ca kinetics revealed turnover rates and pool sizes within the normal range.

  7. The Danish National Cohort Study (DANCOS)

    DEFF Research Database (Denmark)

    Helweg-Larsen, Karin; Kjøller, Mette; Davidsen, Michael;


    This article gives an overview of a nationally representive public health research database in Denmark, the Danish National Cohort Study (DANCOS). DANCOS combines baseline data from health interview surveys with both pre- and post-baseline data from national health registries with date from a re...... Service Register recorded 980,043 contacts with general practitioners and specialist physicians. For 1943-1996, the Danish cancer Registry contained information about one or more cancer diseases among 1,432 people. A total of 4,334 people in the 1994 cohort were re-interview in 2000. DANCOS allows...

  8. 盐度对梭鱼卵和初孵仔鱼的作用

    Institute of Scientific and Technical Information of China (English)

    葛国昌; 宋卫红


    This paper deals with the ef ects of salinity on the eggs and newlyhatched larvae of Mugil so-iuy. It was found that all the fertilized eggs were hatched out within the range of salinity 5‰-40‰, and the normal hatching rate was the highest at 35.6%. Moreover, the larvae hatched at salinity 35.6%0 were able to survive within the range of salinity 5.1‰-43.2‰. And the effect of salinity, on the length of the newly-hatched larvae was discussed.

  9. Comparing the harmful effects of nontuberculous mycobacteria and Gram negative bacteria on lung function in patients with cystic fibrosis

    DEFF Research Database (Denmark)

    Qvist, Tavs; Taylor-Robinson, David; Waldmann, Elisabeth


    BACKGROUND: To better understand the relative effects of infection with nontuberculous mycobacteria and Gram negative bacteria on lung function decline in cystic fibrosis, we assessed the impact of each infection in a Danish setting. METHODS: Longitudinal registry study of 432 patients with cystic...... fibrosis contributing 53,771 lung function measures between 1974 and 2014. We used a mixed effects model with longitudinally structured correlation, while adjusting for clinically important covariates. RESULTS: Infections with a significant impact on rate of decline in %FEV1 were Mycobacterium abscessus...

  10. The Influence of Calcined Clay Pozzolan, Low-Cao Steel Slag and Granite Dust On the Alkali-Silica Reaction in Concrete


    James Sarfo-Ansah; Eugene Atiemo


    The influence of low CaO steel slag, calcined clay and granite dust on the alkali-silica reaction was investigated over a period of 35 days under accelerated curing conditions. The mineral admixtures were used to replace varying portions of high alkali Portland limestone cement up to an admixture content of 25% in order to study their effect on the alkali-silica reaction (ASR). Portland limestone cement used for the study had a total Na2Oeq of 4.32. XRD analysis of hydrated mortar...

  11. The Representation of Older People in East Asian Television Advertisements. (United States)

    Prieler, Michael; Ivanov, Alex; Hagiwara, Shigeru


    In this study, 432 television advertisements from Hong Kong, Japan, and South Korea were analyzed to determine their representations of older people. Findings demonstrate that in East Asian advertisements, older people are highly underrepresented, appear in major roles, mostly alongside younger people, and older men clearly outnumber older women. The other variables investigated (i.e., setting and product categories) led to no conclusive findings for the three societies. In short, our study, employing ethnolinguistic vitality theory to analyze television advertisements, demonstrates how East Asian societies greatly marginalize older people. Potential effects of such representations are discussed using social cognitive theory and cultivation theory.

  12. BAE公司获得“斗牛犬”装甲车升级合同

    Institute of Scientific and Technical Information of China (English)


    英国《简氏防务周刊》报道,英国BAE地面系统公司已赢得一项价值1.401亿美元的后继合同,把另外400辆FV432系列装甲人员输送车及其变型车升级至增强型“斗牛犬”(Bulldog)Mk 3标准配置。

  13. Using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to analyze differentially expressed brain polypeptides in scrapie strain 22L-infected BALB/c mice

    Institute of Scientific and Technical Information of China (English)

    Xiangyu Liao; Chuanjing Ju; Jiayu Wan; Wensen Liu; Xin Tang; Wufei Zhu; Na Xu; Jing Xu; Nan Li; Yaping Chang


    Differentially expressed polypeptides in the brain of a BALB/c mouse model infected with scrapie strain 22L were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The results showed that 21 peptides were down-regulated, with peptides of mass-to-charge ratio 758.772 5 and mass-to-charge ratio 5 432.206 9, demonstrating the most significant decreases. These finding suggest that these peptides are candidate biomarkers and may play an important role in the pathogenesis of prion disease.

  14. Review of Ship Structural Details (United States)


    8 4.3 Knee and Beam Brackets 4-11 4.3.1 Brackets for Girders and Deep Webs 4-11 4.3.2 Brackets Connecting Rolled Sections 4-15 4.4 Tripping...are shell stringers penetrating deep web frames and longitudinal girders penetrating deep transverses. This is not a common detail. If double...34. 3-76 ^"SECTION ’’.’(-K PLAJ iNG * S v *^ 4Fb^:TH»r.KNF.^ SAME AS FLAMGE ► BULKHFADQR DEEP WEB SS- 9 Detail Type: STANCHION END

  15. 长焦悍将OLYMPUS SP-510UZ

    Institute of Scientific and Technical Information of China (English)



  16. High pressure synthesis of marcasite-type rhodium pernitride. (United States)

    Niwa, Ken; Dzivenko, Dmytro; Suzuki, Kentaro; Riedel, Ralf; Troyan, Ivan; Eremets, Mikhail; Hasegawa, Masashi


    Marcasite-type rhodium nitride was successfully synthesized in a direct chemical reaction between a rhodium metal and molecular nitrogen at 43.2 GPa using a laser-heated diamond-anvil cell. This material shows a low zero-pressure bulk modulus of K0 = 235(13) GPa, which is much lower than those of other platinum group nitrides. This finding is due to the weaker bonding interaction between metal atoms and quasi-molecular dinitrogen units in the marcasite-type structure, as proposed by theoretical studies.

  17. 微型相转移超声催化合成扁桃酸%Microscale Synthesis of Mandelic Acid by PhaseTransfer Catalysis and Ultasonic Technique

    Institute of Scientific and Technical Information of China (English)

    殷立国; 何锐刚; 李增春


    回流合成苄基三乙基氯化胺(TEBA),并以之为相转移催化剂,采用超声波技术在微型仪器中合成了扁桃酸.与常量合成方法进行比较,微型的药品用量是常量的22%,反应时间比常量少0.5 h,微型收率(43.2%)比常量收率(58.3%)有所减少.

  18. Projected life expectancy of people with HIV according to timing of diagnosis

    DEFF Research Database (Denmark)

    Nakagawa, Fumiyo; Lodwick, Rebecca K; Smith, Colette J;


    and healthcare, and to assess the effect of late diagnosis on life expectancy. Methods: A stochastic computer simulation model of HIV infection and the effect of ART was used to estimate life expectancy and determine the distribution of potential lifetime outcomes of an MSM, aged 30 years, who becomes HIV...... positive in 2010. The effect of altering the diagnosis rate was investigated. Results: Assuming a high rate of HIV diagnosis (median CD4 cell count at diagnosis, 432¿cells/µl), projected median age at death (life expectancy) was 75.0 years. This implies 7.0 years of life were lost on average due to HIV...... in HIV diagnosis...

  19. Psykologisk svangreprofylakse. Et tvaerfagligt netvaerk i sygehusregi

    DEFF Research Database (Denmark)

    Knop, J; Østerberg-Larsen, B


    AND DISCUSSION: Anxiety and crisis reactions owing to previous PBC, family problems, and concerns about the fetus were the predominant reasons for referral. A total of 87% met the ICD-10 criteria for adjustment disorder (F 43.2), whereas psychotic disorders were infrequent. In 52%, 1-4 sessions were sufficient...... to stabilise the condition. The frequency of PBC in the 106 women was significantly higher when compared to the background sample (n = about 15,000). The establishment of an effective network is recommended for pregnant women suffering from mental distress in order to prepare her for the approaching delivery...

  20. Hypoxia: Exposure Time Until Significant Performance Effects (United States)


    and self-reported symptoms. Additionally, the PowerLab computer system interfaced with the gas analyzer to measure levels of carbon dioxide (CO2) and...processing by hypoxia. Ergonomics , 36(6), 727-35. 4. Fowler, B., Elcombe, D.D., Kelso, B., & Porlier, G. (1987). The threshold for hypoxia effects on... Ergonomics , 25(3), 189-201. 9. Gold, R.E. & Kulak, L.L. (1972). Effect of hypoxia on aircraft pilot performance. Aerospace Medicine, 43(2), 180-3

  1. Autogenic training as a therapy for adjustment disorder in adults


    Jojić Boris R.; Leposavić Ljubica M.


    Introduction. Autogenic training is a widely recognised psychotherapy technique. The British School of Autogenic Training cites a large list of disorders, states, and changes, where autogenic training may prove to be of help. We wanted to explore the application of autogenic training as a therapy for adjustment disorder in adults. Our sample consisted of a homogeneous group of 35 individuals, with an average age of 39.3±1.6 years, who were diagnosed with adjustment disorder, F 43.2, in accord...

  2. Autogenic training as a therapy for adjustment disorder in adolescents


    Jojić Boris R.; Leposavić Ljubica M.


    INTRODUCTION Autogenic training is a widespread technique used in psychotherapy. The British school of autogenic training cites a large list of diseases, health states, and life changes, in which autogenic training can be of help. We wanted to explore the application of autogenic training as a therapy for adjustment disorder in adolescents. The sample consisted of a homogeneous group of 31 individuals, with an average age of 17.3±0.2 years, who were diagnosed with adjustment disorder, F 43.2,...

  3. Engineering Design Handbook. Discontinuous Fiberglass Reinforced Thermoplastics (United States)


    2.4.7 Dryers 4-14 4-2.4.8 Mold Temperature Regulators 4-14 4-2,5 Injection MoldingParameters 4-14 4-2.5.1 General Purpose Glass-Reinforced Resins...Definition 4-32 4-5.2 Materials 4-33 4-5.3 Equipment 4-33 4-5.3.1 Dryers ...called dry coloring, can be accomplished by tumbling in a drum. The drum apparatus is relatively inex- pensive. Color concentrates are also used

  4. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls


    Craddock, Nick; Matthew E. Hurles; Cardin, Niall; Pearson, Richard D.; Plagnol, Vincent; Robson, Samuel; Vukcevic, Damjan; Barnes, Chris; Conrad, Donald F.; Giannoulatou, Eleni; Holmes, Chris; Marchini, Jonathan L.; Stirrups, Kathy; Tobin, Martin D.; Wain, Louise V.


    Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed 19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated 50% of all common CNVs larger than 500 base pa...

  5. Detection of Microcracks in Trunnion Rods Using Ultrasonic Guided Waves (United States)


    image (Figure 1), a blue arrow has been drawn to indicate the fracture origin with white arrows drawn to indicate the crack propagating direction...The green ellipse encircles an area that appears to have been a pre-existing crack, which is more heavily oxidized than the rest of the fracture ... Tungsten 5200 19.4 101.0 Gallium 2740 5.9 16.3 Field’s metal 2617 7.8 20.6 4.3.2 Low melting point metals for ultrasonic coupling In searching for

  6. An Overview of Cirrhosis in Children. (United States)

    Cordova, Jonathan; Jericho, Hilary; Azzam, Ruba K


    Cirrhosis is the end result of nearly all forms of progressive liver disease. The diffuse hepatic process can be characterized as a state of inflammation progressing to fibrosis and resulting in nodular regeneration, ultimately leading to disorganized liver architecture and function. The underlying etiology of cirrhosis in children may often differ from adults owing to specific disease processes that manifest in childhood, including biliary atresia, galactosemia, and neonatal hepatitis. Although basic management strategies in children are similar to those in adults, the care given to children with cirrhosis must keep the child's growth and development of paramount importance. [Pediatr Ann. 2016;45(12):e427-e432.].

  7. Differential Global Positioning System (DGPS) for Flight Testing (Global Positioning System Differentiel (DGPS) pour les Essais en vol) (United States)


    φ < 80° – 4.5 dB 80°≤ φ < 85° – 7.5 dB φ = 90° @ Horizon Weight: 3 oz. Thickness: 0.404 in. Diameter: 3.5 in. Material: Aluminium ... 6061 – T61 / Plastic Cover Connector: TNC Temperature: – 67 °F ÷ 185 °F Vibrations: 10 Gs Height: 55000 ft 4.3.2 Aviation Products...installed on an aluminium -alloy plate. The telemetry antennas were placed at distances of 70 cm and 27 cm respectively from the GPS antenna, in order to

  8. Correction of Phase Distortion by Nonlinear Optical Techniques (United States)


    ward wave oscillators and distributed feedback lasers, occur even in the presence of pump attenuation. It is obvious that pump depletion effects...a*. Efl v* Z* ^iCVb^^f-V VEfl> (4-3-2) Ik -VE +^ V,2 E - n— p p 2k T p 2nc W {M[(I +1 )En - (E -E*) t...offset techniques. (1) Since the pumps may be arranged to be non-counterpropagating with angle offset techniques, feedback of the pump into the

  9. The Design and Analysis of Electrically Large Custom-Shaped Reflector Antennas (United States)


    harmonic non -homogeneous vector wave 16 equation in Equation (2.18) can be done using the FSGF. The assumption that any vector from the surface of the... non -uniform grids, 3-Dimensional grids, and off-axis angles of incidence can be used [14] [24]. In this research, off-axis results are generated to...Transactions on Antennas and Propagation, vol. AP-11, pp. 428–432, July 1963. [21] A. J. Terzuoli, “Class notes, eeng-625, em waves - maxwellian theory

  10. A Fatal Case of Metformin-associated Lactic Acidosis. (United States)

    Ozeki, Toshikazu; Kawato, Rui; Watanabe, Mitsuru; Minatoguchi, Shun; Murai, Yukari; Ryuge, Akihiro; Takasugi, Koji; Hamada, Takuya; Oyama, Yukako; Nomura, Atsushi; Tomino, Tatsuhito; Shimizu, Hideaki; Fujita, Yoshiro


    A 72-year-old woman with a history of type 2 diabetes mellitus was brought to the ER with metformin-associated lactic acidosis. She received continuous hemofiltration and hemodialysis, but the laboratory analyses showed no improvement. She died 11 hours after admission. Metformin is minimally bound to proteins and is readily dialyzable, but a prolonged period of dialysis is required, because metformin has a very large distribution volume and is distributed to multiple compartments. The peak blood metformin level was 432 mg/L in this case, which is one of the highest metformin concentrations ever reported, and eight hours of hemodialysis were not sufficient to reduce the serum level.

  11. The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis. (United States)

    Lu, Ming; Zhang, Jianzhong; Li, Ming; Ge, Xiaoxu; Dai, Xu; Zhao, Jiao; Fu, Mingzhou; Wang, Tao; Fang, Xiyao; Li, Can; Zhang, Rong; Zhao, Weijing; Zheng, Taishan; Wang, Feng; Yu, Ming; Lei, Tao; Wang, Niansong; Bao, Yuqian; Liu, Limei; Liu, Yanjun; Jia, Weiping


    Whether the DD genotype of the angiotensin-I converting enzyme (ACE) I/D variation contributes to end-stage renal disease (ESRD) risk in type 2 diabetes mellitus (T2DM) remains controversial. Differences in study design, case and control definition, sample size and ethnicity may contribute to the discrepancies reported in association studies. We performed a case-control study to evaluate the association of the ACE I/D variation with ESRD risk in Chinese patients with T2DM receiving hemodialysis and analyzed the genotype-phenotype interaction. Unrelated Chinese patients (n = 432) were classified into the non-diabetic nephropathy (DN) control group (n = 222, duration of diabetes >10 years, no signs of renal involvement) and the DN-ESRD group (n = 210; ESRD due to T2DM, receiving hemodialysis). Polymerase chain reaction was used to genotype ACE I/D for all 432 subjects. The frequencies of the ID + DD genotypes were higher in the DN-ESRD group than non-DN control group (65.2 vs. 50.9 %; adjusted OR 1.98 (95 % CI, 1.31-3.00; P = 0.001). In the DN-ESRD group, the DD genotypic subgroup had significantly elevated HbA1c and diastolic blood pressure (DBP) compared to the II subgroup (both P hemodialysis.

  12. Lymphatic malformations: a proposed management algorithm.

    LENUS (Irish Health Repository)

    Oosthuizen, J C


    OBJECTIVE: The aim of this study was to develop a management algorithm for cervicofacial lymphatic malformations, based on the authors\\' experience in managing these lesions as well as current literature on the subject. STUDY DESIGN AND METHODS: A retrospective medical record review of all the patients treated for lymphatic malformations at our institution during a 10-year period (1998-2008) was performed. DATA COLLECTED: age at diagnosis, location and type of lesion, radiologic investigation performed, presenting symptoms, treatment modality used, complications and results achieved. RESULTS: 14 patients were identified. Eight (57%) male and six (43%) female. There was an equal distribution between the left and right sides. The majority (71%) of cases were diagnosed within the first year of life. The majority of lesions were located in the suprahyoid region. The predominant reason for referral was an asymptomatic mass in 7 cases (50%) followed by airway compromise (36%) and dysphagia (14%). Management options employed included: observation, OK-432 injection, surgical excision and laser therapy. In 5 cases (36%) a combination of these were used. CONCLUSION: Historically surgical excision has been the management option of choice for lymphatic malformations. However due to the morbidity and high complication rate associated this is increasingly being questioned. Recent advances in sclerotherapy e.g. OK-432 injection have also shown significant promise. Based on experience in managing these lesions as well as current literature the authors of this paper have developed an algorithm for the management of cervicofacial lymphatic malformations.

  13. A Note on the Skew Energy of Digraphs%有向图反能量的一个注记

    Institute of Scientific and Technical Information of China (English)

    崔淑玉; 田贵贤


    有向图的反能量是指有向图的反邻接矩阵的能量.本文利用有向图的运算构造出了几类有向图,它们中的每一个都满足有向图的反能量等于其底图的能量.部分回答了Adiga等人在文[The skew energy of a digraph,Linear Algebra Appl.,2010,432:1825 1835]中提出的一个公开问题.%The skew energy (&)s (D) of a digraph D is defined as the energy of its skewadjacency matrix.In this paper,employing many operations of digraphs,we construct several classes of digraphs,each one of which satisfies its skew energy is the same as the energy of its underlying graph.This work partly answers a problem proposed by Adiga et al.[The skew energy of a digraph,Linear Algebra Appl.,2010,432:1825-1835].


    Directory of Open Access Journals (Sweden)

    Rakesh K


    Full Text Available : INTRODUCTION: Mesh inguinal hernioplasty is one of the most commonly performed surgery by general surgeons. One of the significant problems following hernia repair is recurrence. Prosthetic materials like polypropylene mesh has been used for inguinal hernia repair and has many advantages like low recurrence rates, less postoperative pain, decreased hospital stay and fewer complications. MATERIALS AND METHODS: In this prospective study, 432 open Lichenstein tension-free inguinal mesh hernioplasty was performed between June 2004 and May 2014. Various parameters regarding postoperative complications were studied. RESULTS: In 432 cases, inguinal hernia was indirect in 59.03% of cases (255 cases, direct in 36.57% (158 cases and of the pantaloon (mixed type in 4.39% (18 cases. Mean age of patients was 50.8 years (range 19–92. The median follow-up period was 2.1 years (range 1 month–5 years. Seroma and hematoma formation requiring drainage was observed in 9 and 11 patients, respectively, while transient testicular swelling occurred in 28 patients. We have not observed acute infection or abscess formation related to the presence of the foreign body (mesh. There was one recurrence of the hernia. Residual neuralgia was observed in 3 patients. CONCLUSION: Lichtenstein Tension-free mesh hernioplasty has many advantages of being simple, effective, low recurrence rate, early return to daily activities and good patient compliance and satisfaction. This technique is preferable for hernia repair in our setting.

  15. Isolation and characterization of novel S-equol-producing bacteria from brines of stinky tofu, a traditional fermented soy food in Taiwan. (United States)

    Abiru, Yasuhiro; Ueno, Tomomi; Uchiyama, Shigeto


    Six strains capable of transforming daidzein to S-equol were isolated from the fermented brines of stinky tofu purchased in Taiwan. Daidzein was completely converted into S-equol within 24h of incubation in five strains. All the strains were gram-positive, rod-shaped, obligately anaerobic, non-motile, and non-spore-forming. In a phylogenetic analysis based on 16S rRNA gene sequences, the strains distributed into three groups in the family Coriobacteriaceae. SNR40-432 (Group I) showed 98.6% 16S rRNA gene similarity and 48-49% DNA-DNA relatedness with Paraeggerthella hongkongensis HKU10(T), suggesting the possibility that SNR40-432 represents a new species in the genus Paraeggerthella. SNR48-44 (Group II) and SNR44-10, SNR45-571, SNR46-41, SNR48-350 (Group III) showed a maximum of 92.2 and 92.1% 16S rRNA gene similarities with Eggerthella sinensis HKU14(T) and Eggerthella lenta JCM9979(T), respectively, which denotes that each group may represent a novel genus and species in the family Coriobacteriaceae. This is the first report isolating equol-producing bacteria from food.

  16. Transarterial chemoembolization alone and in combination with other therapies: a comparative study in an animal HCC model

    Energy Technology Data Exchange (ETDEWEB)

    Maataoui, A.; Qian, J.; Vossoughi, D.; Khan, M.F.; Vogl, T.J. [Johann Wolfgang Goethe University, Institute for Diagnostic and Interventional Radiology, Frankfurt/Main (Germany); Oppermann, E.; Bechstein, W.O. [Johann Wolfgang Goethe University, Department of Visceral Surgery, Frankfurt/Main (Germany)


    The purpose of this study is to compare transarterial chemoembolization (TACE) alone and in combination with other therapies in an animal model. Subcapsular implantation of a solid Morris hepatoma 3924A in the liver was carried out in 50 male ACI rats (day 0). Tumor volume (V1) was measured by MRI (day 13). After laparotomy and retrograde placement of a catheter into the gastroduodenal artery (day 14), the following protocols of the interventional procedure were applied: TACE (mitomycin C + lipiodol) + immunotherapy (group A: TNF{alpha} + IL-2, group B: OK-432 + IL-2); TACE + antiangiogenesis therapy (group C: TNP-470, group D: endostatin); TACE alone in group E (control group). Tumor volume (V2) was assessed by MRI and the mean ratio of x(V2/V1) was calculated. Data were analyzed using Dunnett's ttest (comparing therapeutic groups with the control group) and the Student-Newman-Keuls test (comparing significant therapeutic groups). Multivariate analysis showed a significant reduction in the tumor growth rate (P<0.05) in groups B (x=6.53) and C (x=4.01) compared to the mean ratio of the control group E (x=9.14). Significant results were observed in group C (P<0.05) in comparison with the other therapeutic groups. TACE combined with immunotherapy (OK-432) and antiangiogenesis therapy (TNP-470) retards tumor growth compared with TACE alone in an HCC animal model. (orig.)

  17. HPLC法测定14个地区山楂中羽扇豆醇的含量%Determination of lupeol in Fructus Crataegi from 14 different areas by HPLC

    Institute of Scientific and Technical Information of China (English)

    高婷; 曹阳; 贾凌云; 丁宏; 孙启时


    目的 建立测定山楂中羽扇豆醇含量的方法.方法 采用HPLC法.色谱柱为Diamonsil C18柱(200 mm×4.6 mm,5 μm),流动相为甲醇-水(体积比60:40),流速为1.0 mL·min-1,检测波长为205 nm,柱温为25℃,进样量为10 μL.结果 羽扇豆醇质量浓度在0.4324.32 mg·L-1内与峰面积呈良好的线性关系,r=0.999 8(n=5),平均回收率为95.5%(RSD=3.2%,n=9).结论 该方法简便,准确,重现性好,可用于山楂药材的质量评价.

  18. Effect of Ultra High Pressure on Microbes and Lycopene in Tomato Sauce%超高压对番茄酱中微生物及番茄红素的影响

    Institute of Scientific and Technical Information of China (English)

    纵伟; 曹益恒; 敬思群; 时慧; 赵光远


    In order to study the effect of ultra high pressure (UHP) treatment on microbes and lyco pene in tomato sauce,the effects of ultra high pressure,treatment time and temperature on microbes and lycopene are studied.The results show that when tomato sauce is treated at 500 MPa,50 ℃for 10 min,the microbes in tomato sauce can be killed.The cis-lycopene in tomato sauce is 43.2%.UHP has sterilization and cis-trans isomerization effect on lycopene.%为研究超高压处理对番茄酱中微生物及番茄红素的影响,将番茄酱在超高压下进行处理,考察了超高压压力、处理时间和温度对菌落总教和番茄红素的影响.结果表明:50℃下经500 MPa,10 min处理,番茄酱中微生物全部被杀灭,番茄酱顺式番茄红素比例达到43.2%,超高压处理不仅可起到杀菌作用,还具有对番茄红素顺反异构转化的作用.

  19. Astrometry of Pluto from 1930-1951 observations: The Lampland plate collection

    Energy Technology Data Exchange (ETDEWEB)

    Buie, Marc W. [Southwest Research Institute, 1050 Walnut St., Suite 300, Boulder, CO 80302 (United States); Folkner, William M., E-mail:, E-mail: [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Dr., Pasadena, CA 91109-8099 (United States)


    We present a new analysis of 843 photographic plates of Pluto taken by Carl Lampland at Lowell Observatory from 1930–1951. This large collection of plates contains useful astrometric information that improves our knowledge of Pluto's orbit. This improvement provides critical support to the impending flyby of Pluto by New Horizons. New Horizons can do inbound navigation of the system to improve its targeting. This navigation is capable of nearly eliminating the sky-plane errors but can do little to constrain the time of closest approach. Thus the focus on this work was to better determine Pluto's heliocentric distance and to determine the uncertainty on that distance with a particular eye to eliminating systematic errors that might have been previously unrecognized. This work adds 596 new astrometric measurements based on the USNO CCD Astrograph Catalog 4. With the addition of these data the uncertainty of the estimated heliocentric position of Pluto in Developmental Ephemerides 432 (DE432) is at the level of 1000 km. This new analysis gives us more confidence that these estimations are accurate and are sufficient to support a successful flyby of Pluto by New Horizons.

  20. 丙酮肟氧化偶联合成2,3-二甲基-2,3-二硝基丁烷反应的研究%Synthesis of 2,3-Dimethyl-2,3-dinitrobutane by Oxidative Coupling of Acetone Oxime

    Institute of Scientific and Technical Information of China (English)

    张胜建; 赵迎宪; 张洪


    2,3-Dimethyl-2,3-dinitrobutane (DMNB) was prepared by oxidative coupling of acetone oxime with H2O2 over the modified TS-1 catalyst. In one-pot operation, the ammoximation of acetone followed by catalytic oxidative coupling over TS-1 produced the DMNB with yield of 43.2%. The operation is simple and safe. The structures of products were identified by 1H NMR and 13C NMR spectra.%以丙酮肟为原料,在改性TS-1(钛硅分子筛)催化剂催化下,可用H2O2氧化偶联合成2,3-二甲基-2,3-二硝基丁烷(DMNB).在此基础上以丙酮为原料,在改性TS-1催化剂催化下,一锅法进行丙酮氨肟化和氧化偶联反应可制备收率43.2%的DMNB.该方法简便易操作,操作安全.产物结构经1H NMR,13C NMR表征.

  1. Portal vein stenting as a signiifcant risk factor for biliary stricture in adult living donor liver transplantation

    Institute of Scientific and Technical Information of China (English)

    Min-Ho Shin; Gil-Chun Park; Young-In Yun; Wan-Jun Kim; Woo-Hyoung Kang; Seok-Hwan Kim; Gi-Young Ko; Deok-Bog Moon; Sung-Gyu Lee; Shin Hwang; Ki-Hun Kim; Chul-Soo Ahn; Tae-Yong Ha; Gi-Won Song; Dong-Hwan Jung


    BACKGROUND: Although perioperative portal vein (PV) stent implantation is an effective treatment for steno-occlusive disease in adult living donor liver transplantation (LDLT) re-cipients, we experienced high incidence of biliary anastomotic strictures (BAS) after PV stenting. In this study, we sought to clarify the relation between BAS and PV stenting and to suggest the possible mechanism of BAS and measures to reduce its in-cidence. METHODS: We retrospectively analyzed 44 LDLT recipients who underwent PV stent implantation across the line of PV anastomosis regardless of the location of steno-occlusion (stent group) and their matched controls (non-stented LDLT recipients, n=131). RESULTS: The incidence of BAS was higher in patients in the stent group than that in the control group (43.2% vs 17.6%, P=0.001). Cumulative 6-month and 1-, 2- and 5-year BAS rates were 31.8%, 34.1%, 41.4% and 43.2%, respectively, in the stent group and 13.0%, 13.8%, 16.1% and 17.8%, respectively, in the control group (P=0.001). Multivariate analysis revealed that PV stenting was an independent risk factor for BAS. CONCLUSIONS: Although PV stent implantation is a reliable treatment modality for steno-occlusive PV in adult LDLT recipients, innovative methods to prevent the PV stent from crossing the line of PV anastomosis may be necessary to reduce the incidence of postoperative BAS.

  2. Tics and Tourette syndrome: clinical evaluation of 44 cases

    Directory of Open Access Journals (Sweden)

    Teive Hélio A.G.


    Full Text Available We evaluated 44 patients with tics and Tourette's syndrome (TS emphasising the age of onset of symptoms, sex, classification and localization of tics, associated symptoms and signs and comorbidities. Thirty-three patients (75.2% had TS defined criteria whereas 10 (22.7% had chronic motor and/or vocal tics. Simple motor tics were found in 43 cases (97.7%, mainly affecting the eyes (43.2%, mouth (43.2%, face (34.1%. Simple vocal tics occurred in 33 (75%. Coprolalia was found in just 6 cases (13.6% and copropraxia in just 2 (4.5%. Obsessive compulsive disorder and/or symptoms were found in 26 cases (59.1% and attention deficit in 17 (38.6%. Eighteen patients (40.9% had other disorders, such as alcoholism, tabagism, drug abuse, affective disorders, anxiety, sleep and learning disorders. The data obtained are similar to those found by other authors. We highlight the low frequency of coprolalia, as well as the associated neuropsychiatric disorders.

  3. Performance of MC2 and the ECMWF IFS Forecast Model on the Fujitsu VPP700 and NEC SX-4M

    Directory of Open Access Journals (Sweden)

    Michel Desgagné


    Full Text Available The NEC SX-4M cluster and Fujitsu VPP700 supercomputers are both based on custom vector processors using low-power CMOS technology. Their basic architectures and programming models are however somewhat different. A multi-node SX-4M cluster contains up to 32 processors per shared memory node, with a maximum of 16 nodes connected via the proprietary NEC IXS fibre channel crossbar network. A hybrid combination of inter-node MPI message-passing with intra-node tasking or threads is possible. The Fujitsu VPP700 is a fully distributed-memory vector machine with a crossbar interconnect which also supports MPI. The parallel performance of the MC2 model for high-resolution mesoscale forecasting over large domains and of the IFS RAPS 4.0 benchmark are presented for several different machine configurations. These include an SX-4/32, an SX-4/32M cluster and up to 100 PE's of the VPP700. Our results indicate that performance degradation for both models on a single SX-4 node is primarily due to memory contention within the internal crossbar switch. Multinode SX-4 performance is slightly better than single node. Longer vector lengths and SDRAM memory on the VPP700 result in lower per processor execution rates. Both models achieve close to ideal scaling on the VPP700.

  4. Expression analysis of a Na~+/H~+ antiporter gene PeNHX1 from Populus euphratica

    Institute of Scientific and Technical Information of China (English)


    Na+/H+ antiporters play an important role in the salt tolerance of a wide variety of plants.Using the rapid amplification of cDNA ends method,a Na+/H+ antiporter gene (PeNHX1) was isolated from Populus euphratica.The deduced amino acid sequence contained 528 amino acid residues with a conserved amiloride-binding domain (77LFFIYLLPPI86) and shared more than 68% identity with that of AtNHX1 from Arabidopsis thaliana.PeNHX1 can confer resistance to Na+,as well as Li+,to (EP432) an Escherichia coli strain deficient in both nhaA and nhaB,thus proving that it is a functional Na+/H+ antiporter.PeNHX1 expression profile in EP432 reflected pH independent manner.PeNHX1 expression was regulated by salt at the transcriptional level.Meanwhile,results demonstrated that transcripts of PeNHX1 in P.euphratica calli showed a salt dependent response,and thus provide a valuable tool for studying signaling and biochemical pathways involved in salt recognition and response in P.euphratica.

  5. Microstructures and mechanical properties of Mg–Zn–Zr–Dy wrought magnesium alloys

    Indian Academy of Sciences (India)

    Z H Huang; W J Qi; K H Zheng; X M Zhang; M Liu; Z M Yu; J Xu


    Microstructures and phase compositions of as-cast and extruded ZK60–Dy ( = 0–5) alloys were analysed by optical microscope, scanning electron microscope, X-ray diffraction and differential scanning calorimetry. Meanwhile, the tensile mechanical property was tested.With increasing Dy content, Mg–Zn–Dy new phase increases gradually, while MgZn2 phase decreases gradually to disappear. As-cast microstructure is refined gradually; meanwhile extruded one is refined further with decreasing average grain size to 1 m for ZK60–4.32Dy alloy. Second phase, tending to distribute along grain boundary by continuous network in as-cast state, breaks and distributes dispersedly in extrusion state. As-cast tensile mechanical property remains almost unchanged at ambient temperature; however, extruded ones are enhanced significantly at ambient and elevated temperatures, respectively. Tensile strength at 298 and 473 K increases gradually from 355 and 120 MPa for ZK60 alloy to 395 and 171 MPa for ZK60–4.32Dy alloy, respectively. Extruded tensile fractures exhibit a typical character of ductile fracture.

  6. 高产耐热脂肪酶嗜热脂肪地芽孢杆菌的选育%Breeding of Geobacillus stearothermophilus for high producing thermostable lipase

    Institute of Scientific and Technical Information of China (English)

    戚薇; 冯艳蕊; 王海宽; 王建玲; 邵静


    采用氮离子注入技术对耐热脂肪酶产生菌嗜热脂肪地芽孢杆菌( Geobacillus stearother mophilus )L4进行诱变,筛选获得酶活力有较大提高且传代稳定的正突变菌株L4-3;再对 L4-3进行紫外线诱变,得到脂肪酶活力提高的正突变菌株L4-3-2,其脂肪酶活力达25.71 U/ mL,较原始菌株L4提高511.9%.高产突变株L4-3-2所产脂肪酶的最适作用温度为50℃,70 ℃保温60min的剩余酶活为82%,最适作用pH为7.0~8.0,为一种耐热碱性脂肪酶.外诱变参考文献胡朝阳, 韦晗宁, 李春苑, 等. 产脂肪酶菌株的筛选及酶学特性研究.

  7. Evaluation of powder metallurgy superalloy disk materials (United States)

    Evans, D. J.


    A program was conducted to develop nickel-base superalloy disk material using prealloyed powder metallurgy techniques. The program included fabrication of test specimens and subscale turbine disks from four different prealloyed powders (NASA-TRW-VIA, AF2-1DA, Mar-M-432 and MERL 80). Based on evaluation of these specimens and disks, two alloys (AF2-1DA and Mar-M-432) were selected for scale-up evaluation. Using fabricating experience gained in the subscale turbine disk effort, test specimens and full scale turbine disks were formed from the selected alloys. These specimens and disks were then subjected to a rigorous test program to evaluate their physical properties and determine their suitability for use in advanced performance turbine engines. A major objective of the program was to develop processes which would yield alloy properties that would be repeatable in producing jet engine disks from the same powder metallurgy alloys. The feasibility of manufacturing full scale gas turbine engine disks by thermomechanical processing of pre-alloyed metal powders was demonstrated. AF2-1DA was shown to possess tensile and creep-rupture properties in excess of those of Astroloy, one of the highest temperature capability disk alloys now in production. It was determined that metallographic evaluation after post-HIP elevated temperature exposure should be used to verify the effectiveness of consolidation of hot isostatically pressed billets.

  8. Personal, social and environmental predictors of daily fruit and vegetable intake in 11-year-old children in nine European countries

    DEFF Research Database (Denmark)

    De Bourdeaudhuij, I; Te Velde, S; Brug, J;


    Objective:To investigate potential personal, social and physical environmental predictors of daily fruit intake and daily vegetable intake in 11-year-old boys and girls in nine European countries.Subjects:The total sample size was 13 305 (90.4% participation rate).Results:Overall, 43.2% of the ch......Objective:To investigate potential personal, social and physical environmental predictors of daily fruit intake and daily vegetable intake in 11-year-old boys and girls in nine European countries.Subjects:The total sample size was 13 305 (90.4% participation rate).Results:Overall, 43.......2% of the children reported to eat fruit every day, 46.1% reported to eat vegetables every day. Daily fruit intake and daily vegetable intake was mainly associated with knowledge of the national recommendations, positive self-efficacy, positive liking and preference, parental modeling and demand and bringing fruit...... to school (odds ratio between 1.40 and 2.42, P

  9. Potassium and magnesium succinatouranilates - Synthesis and crystal structure (United States)

    Novikov, S. A.; Grigoriev, M. S.; Serezhkina, L. B.; Serezhkin, V. N.


    Single crystal X-ray diffraction has been applied to determine the structures of two new uranyl coordination polymers: K2[(UO2)2(C4H4O4)3] (1) and [Mg(H2O)6] [(UO2)2(C4H4O4)3]·2H2O (2), where C4H4O42- is succinate anion. Crystals of 1 and 2 contain polymeric complex anions [(UO2)2(C4H4O4)3]2- with the same A2Q023 crystallochemical formula (A=UO22+, Q02=C4O4H42-), and have layered (1) or chain (2) structure. It has been found, that conformation of succinate ions is one of the factors, which affects the structure of [(UO2)2(C4H4O4)3]2- anions. IR spectra of these new compounds are in good agreement with crystallographic data. Topological analysis of the uranium dicarboxylates with A2Q023 crystallochemical formula has shown the presence of five isomers which differ from each other in coordination sequences and / or dimensionality.

  10. Prediction of Extrusion Pressure And Product Deflection Of Using Artificial Neural Network

    Directory of Open Access Journals (Sweden)

    D.T. GUNDU


    Full Text Available - In this paper artificial neural network was used as a modeling tool for simulation and prediction of extrusion pressure and product deflection of extrudes of lead alloys. An extensive experimental program was undertaken to extrude a lead (Pb alloy on ELE Compact-1500 compression machine. The neural model of extrusion pressure and product deflection was developed based on groups of experiments carried out as samples, Eight (8 die bearing parameters (die bearing length, radius of curvature, slip angle, die angle, die ratio ram displacement, pocket depth and die diameter were used as inputs into the network architecture of 8 [4-3]2 2 in predicting the extrusion pressure and product deflection. After series of network architectures were trained using different training algorithms such as Levenberg-Marquardt, Bayesian Regulation, Resilient Backpropagation using MATLAB 7.9.0 (R20096, the LM8 [4-3]2 2 was selected as the most appropriate model. Prediction of the neural model exhibited reasonable correlation with the experimental extrusion pressure and product deflection. The predicted extrusion pressure and product deflection gave reasonable errors and higher correlation coefficients indicating that the model is robust for predicting extrusion pressure and product deflection.

  11. Initial Operation Results of the KOMAC 100MeV Proton Linac

    Energy Technology Data Exchange (ETDEWEB)

    Seol, Kyungtae; Kwon, Hyeokjung; Kim, Hansung; Kim, Daeil; Song, Younggi; Cho, Yongsub [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    The Korea multi-purpose accelerator complex (KOMAC) accelerator facility has a 100-MeV proton linac, five beam lines for 20-MeV beam utilization, and another five beam lines for 100-MeV beam utilization. The 100-MeV linac consists of a 50-keV proton injector based on a microwave ion source, a 3-MeV RFQ with a four-vane structure, and a 100-MeV DTL. The KOMAC started to provide a proton beam to users on July 2013. A 20-MeV beam line and a 100-MeV beam line have been operated for beam service during the first year. In 2013, the proton linac had been operated for more than 2200 hours and beam service time was 432 hours approximately. The accumulated downtime during the first year in 2013 is 94.7 hours and there were some faults at utilities, high voltage modulators, and RF components. The KOMAC started to provide a proton beam to users on July 2013. The proton linac had been operated for more than 2200 hours and beam service time was 432 hours approximately. Accumulated downtime was 94.7 hours and availability was 82 %. The plan for beam power and operation time in 2014 is 10 kW and 2500 hours respectively.

  12. The effects of enhanced ultraviolet-B radiation on the biology of green and brown morphs of Sitobion avenae (Hemiptera: Aphididae). (United States)

    Hu, Zu-Qing; Zhao, Hui-Yan; Thieme, Thomas


    The effects of enhanced UV-B radiation on the biology of green and brown morphs of Sitobion avenae (F.) (Hemiptera: Aphididae) were tested under laboratory conditions. The two S. avenae morphs were exposed directly to different doses (0, 216, 432, and 864 kJ/m(2)) of artificial UV-B. Under low doses of UV-B (216 kJ/m(2)), the nymphal development period was significantly shorter, whereas mean relative growth, total fecundity, and gross reproductive rate were significantly higher for both aphid morphs compared with those morphs under control treatments (0 kJ/m(2)). Under high doses of UV-B (432 kJ/m(2) and/or 864 kJ/m(2)), the nymphal development period was significantly longer, whereas the reproductive period, postreproductive period, difference in weight, mean relative growth, and life table parameters were significantly reduced for both aphid morphs. Moreover, the nymphal development period was significantly shorter and the differences in weight, mean relative growth, total fecundity, and life table parameters were significantly higher for the brown morph under high doses of UV-B compared with the green morph. The results showed that enhanced UV-B affects the performance of the green and brown S. avenae morphs from positively to negatively. The brown morph exhibited stronger adaptability than the green morph at high doses of UV-B.

  13. CYP1B1基因多态性与妊娠期肝内胆汁淤积症易感性的关系%Association of Gene Polymorphisms of CYP1B1 with Intrahepatic Cholestasis of Pregnancy

    Institute of Scientific and Technical Information of China (English)

    王晓莉; 谭欣; 张力; 欧容清; 颜爱华; 陈强; 邹海


    目的 研究CYP1B1基因外显子2密码子119(G-T)和外显子3密码子432(C-G)多态性与妊娠期肝内胆汁淤积症(ICP)发病的关系.方法 分别应用等位基因特异性PCR(AS-PCR)技术和人工修饰双等位基因特异性引物扩增(diASA-AMP)法,对100例ICP患者和100例正常对照孕妇CYP1B1基因外显子2密码子119(G-T)和外显子3密码子432(C-G)多态性进行分析.结果 ①CYP1B1基因密码子119多态分析表明ICP组T等位基因频率高于对照组(P0.05).结论 CYP1B1基因外显子2密码子119多态性可能与成都地区ICP易感性有关.

  14. Career pressure of psychiatric nurses and the solution%精神科护士职业压力与解决工作压力的对策和办法

    Institute of Scientific and Technical Information of China (English)



    目的:探讨精神科护士职业压力的原因,为精神病护士管理者预防和解决精神病护士职业压力问题提供依据。方法通过问卷调查与口头交流的方式,对432名精神科护士展开调查,并进行分析统计。结果新的管理办法使拥有消极倦怠情绪的护士比例大幅下降。结论使用新的护理管理模式,可以有效缓解护士心理压力,并对提高其工作热情具有一定的指导意义。%Objective to discuss the career pressue of psychiatric nurses, then provide basis for the psychiatric nurses’ managers to prevent and solve the career pressue of psychiatric nurses. Methods Using questionnaire investigation and oral communication to investigate 432 nurses. Results new management method largely reduce the ratio of nurses who are in negative mood. Conclusions new nursing managemengt model can release the mental pressue of nurses effciently, and this model is significant to motivate nurses’ working passion.

  15. Ectoparasitic species from Felis catus domesticus (Linnaeus, 1758 in João Pessoa city, Paraíba state, Brazil

    Directory of Open Access Journals (Sweden)

    Débora Rochelly Alves Ferreira


    Full Text Available The goal of this research was to analyze the ectoparasitic species from domestic cats in João Pessoa city, Paraíba state, Brazil. A total of 432 cats of various breeds and ages, of both genders, were included. All animals were submitted to physical and parasitological examination through skin inspection and an otoscopic exam was realized. Parasites were collected in vials containing 70% alcohol for subsequent mounting and identifi cation according to specific keys. The results showed that 62.7% (271/432 of animals were parasitized by one or more species. The ectoparasitic species observed were Ctenocephalides felis (27.3%, Lynxacarus radovskyi (26.2%, Otodectes cynotis (17.4%, Felicola subrostratus (9.7%, Notoedres cati (2.1% and Rhipicephalus sanguineus (1.6%. The results showed that ectoparasites are a common and important skin disease in cats, and variables such breed, age, and sex did not show any influence on parasitism.

  16. The pore-forming toxin proaerolysin is activated by furin. (United States)

    Abrami, L; Fivaz, M; Decroly, E; Seidah, N G; Jean, F; Thomas, G; Leppla, S H; Buckley, J T; van der Goot, F G


    Aerolysin is secreted as an inactive dimeric precursor by the bacterium Aeromonas hydrophila. Proteolytic cleavage within a mobile loop near the C terminus of the protoxin is required for oligomerization and channel formation. This loop contains the sequence KVRRAR432, which should be recognized by mammalian proprotein convertases such as furin, PACE4, and PC5/6A. Here we show that these three proteases cleave proaerolysin after Arg-432 in vitro, yielding active toxin. We also investigated the potential role of these enzymes in the in vivo activation of the protoxin. We found that Chinese hamster ovary cells were able to convert the protoxin to aerolysin in the absence of exogenous proteases and that activation did not require internalization of the toxin. The furin inhibitor alpha1-antitrypsin Portland reduced the rate of proaerolysin activation in vivo, and proaerolysin processing was even further reduced in furin-deficient FD11 Chinese hamster ovary cells. The cells were also less sensitive to proaerolysin than wild type cells; however, transient transfection of FD11 cells with the cDNA encoding furin conferred normal sensitivity to the protoxin. Together these findings argue that furin catalyzes the cell-surface activation of proaerolysin in vivo.

  17. Infusion sclerotherapy of microcystic lymphatic malformation: Clinico-radiological mid-term results

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Min; Lee, Seok Jong; Chung, Ho Yun; Huh, Seung; Kim, Hyung Kee [Dept. of urgery, Kyungpook National University Hospital, Daegu (Korea, Republic of)


    A new sclerotherapy technique by slow mechanical infusion of sclerosant was validated for treatment of microcystic lymphatic malformation (mLM). Seventeen consecutive patients with mLM in extremities, cervicofacial area, and trunk were included (21.8 ± 21.5 years old, male:female = 5:12). All patients diagnosed as mLM were included. A total 4-32 mL 20-38% OK-432 solution was mechanically infused at the rate of 10 mL/hour into the mLM lesions. The treatment effect was estimated clinic-radiologically at the 4-month follow-up. Repeated sclerotherapy followed in the 6th month, if required. The therapeutic effect was evaluated using quantitative ultrasonographic examination including soft tissue thickness, cyst size and number. In 17 patients, total 31 infusion sclerotherapy sessions were performed and monitored for 425 ± 266 days. Fifteen patients (88%) showed improvement in all symptoms, signs, and ultrasonographic findings. In all cases, at least one finding presented improvement. The maximal number of cysts per ultrasonographic window and maximal diameter of the largest cyst decreased by 57 ± 57% and 51 ± 67%, respectively (p = 0.102, 0.004). The soft tissue thickness decreased by 18 ± 15% (p < 0.01). No significant complications such as distal lymphedema or skin necrosis occurred. Infusion sclerotherapy is a safe and effective treatment technique for microcystic LM, with improved outcome.

  18. Crystallization and X-ray data analysis of the 10 kDa C-terminal lid subdomain from Caenorhabditis elegans Hsp70

    Energy Technology Data Exchange (ETDEWEB)

    Worrall, Liam; Walkinshaw, Malcolm D., E-mail: [School of Biological Sciences, University of Edinburgh, The King’s Buildings, Mayfield Road, Edinburgh EH9 3JR,Scotland (United Kingdom)


    Crystals of the C-terminal 10 kDa lid subdomain from the C. elegans chaperone Hsp70 have been obtained that diffract X-rays to ∼3.5 Å and belong to space group I2{sub 1}2{sub 1}2{sub 1}. Analysis of X-ray data and initial heavy-atom phasing reveals 24 monomers in the asymmetric unit related by 432 non-crystallographic symmetry. Hsp70 is an important molecular chaperone involved in the regulation of protein folding. Crystals of the C-terminal 10 kDa helical lid domain (residues 542–640) from a Caenorhabditis elegans Hsp70 homologue have been produced that diffract X-rays to ∼3.4 Å. Crystals belong to space group I2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = b = 197, c = 200 Å. The Matthews coefficient, self-rotation function and Patterson map indicate 24 monomers in the asymmetric unit, showing non-crystallographic 432 symmetry. Molecular-replacement studies using the corresponding domain from rat, the only eukaryotic homologue with a known structure, failed and a mercury derivative was obtained. Preliminary MAD phasing using SHELXD and SHARP for location and refinement of the heavy-atom substructure and SOLOMON for density modification produced interpretable maps with a clear protein–solvent boundary. Further density-modification, model-building and refinement are currently under way.

  19. Enterobacteria identification and detection of diarrheagenic Escherichia coli in a Port Complex

    Directory of Open Access Journals (Sweden)

    Clarissa Frota Macatrão Costa


    Full Text Available The Port Complex of Maranhão (PCM is the second largest port complex in Brazil, receiving ships with large volumes of ballast water. To evaluate the microbiological quality of its waters, physicochemical parameters (pH and salinity, the number of coliforms (thermotolerants and totals, and the presence of enterobacterias and diarrheagenic Escherichia coli strains were analyzed. In order to identify the presence of E. coli virulence genes target regions of the stx, elt, est, aggR, CVD432, ipaH and eae nucleotide sequences were studied. The presence of totals and thermotolerants coliforms were positive. Analyzing the salinity parameter, a significant increase in total coliforms was observed during the rainy season. We identified the species Escherichia coli, Proteus mirabilis, Citrobacter freundii, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella ozaenae, Morganella morganii, Enterobacter cloacae and Edwardsiella tarda. Out of the 51 E. coli isolated, two were positive for the elt gene and one was positive for the CVD432 sequence, features of enterotoxigenic and enteroaggregative strains, respectively. This study reveals that the PCM is contaminated by enterobacteria and diarrheagenic E.coli thus providing evidence regarding the risk of these bacteria being carried by ships to other countries, and draws attention to the input of fecal bacteria brought by ships in the port waters of Maranhão.

  20. Construction of the BAC Library of Small Abalone (Haliotis diversicolor) for Gene Screening and Genome Characterization. (United States)

    Jiang, Likun; You, Weiwei; Zhang, Xiaojun; Xu, Jian; Jiang, Yanliang; Wang, Kai; Zhao, Zixia; Chen, Baohua; Zhao, Yunfeng; Mahboob, Shahid; Al-Ghanim, Khalid A; Ke, Caihuan; Xu, Peng


    The small abalone (Haliotis diversicolor) is one of the most important aquaculture species in East Asia. To facilitate gene cloning and characterization, genome analysis, and genetic breeding of it, we constructed a large-insert bacterial artificial chromosome (BAC) library, which is an important genetic tool for advanced genetics and genomics research. The small abalone BAC library includes 92,610 clones with an average insert size of 120 Kb, equivalent to approximately 7.6× of the small abalone genome. We set up three-dimensional pools and super pools of 18,432 BAC clones for target gene screening using PCR method. To assess the approach, we screened 12 target genes in these 18,432 BAC clones and identified 16 positive BAC clones. Eight positive BAC clones were then sequenced and assembled with the next generation sequencing platform. The assembled contigs representing these 8 BAC clones spanned 928 Kb of the small abalone genome, providing the first batch of genome sequences for genome evaluation and characterization. The average GC content of small abalone genome was estimated as 40.33%. A total of 21 protein-coding genes, including 7 target genes, were annotated into the 8 BACs, which proved the feasibility of PCR screening approach with three-dimensional pools in small abalone BAC library. One hundred fifty microsatellite loci were also identified from the sequences for marker development in the future. The BAC library and clone pools provided valuable resources and tools for genetic breeding and conservation of H. diversicolor.

  1. Guidance for the Implementation and Follow-up of Identified Energy and Water Efficiency Measures in Covered Facilities

    Energy Technology Data Exchange (ETDEWEB)



    This document provides specific guidance to agencies on the implementation and follow-up of energy and water efficiency measures identified and undertaken per Section 432 of the Energy Independence and Security Act of 2007 (EISA) (42 U.S.C. 8253(f)(4) and (5)) This guidance also provides context for how these activities fit into the comprehensive approach to facility energy and water management outlined by the statute and incorporates by reference previous DOE guidance released for Section 432 of EISA and other related documents. 42 U.S.C. 8253(f)(7)(A) specifies that facility energy managers shall certify compliance for each covered facility with the 42 U.S.C. 8253(f)(2)-(5) requirements via a web-based tracking system and make it publicly available. This document also describes the role of the tracking system that has been developed for the collection and reporting of data needed for the demonstration of compliance and progress toward meeting all energy and water efficiency requirements outlined in the statute.

  2. 舌下腺切除术的并发症及处理的临床回顾分析%A retrospective study on complications and management of ranulas with the sublingual gland excision.

    Institute of Scientific and Technical Information of China (English)

    丁晓勇; 周杰; 陈仙芝; 蔡贤忠


    目的:分析舌下腺切除术治疗舌下腺囊肿的并发症及处理方法.方法:回顾分析682例舌下腺切除术治疗舌下腺囊肿病例,分析总结其并发症的种类、发生率、发生原因及处理结果,提示术中术后的注意点.结果:术后出血、舌神经损伤、感染发生较少,颌下腺导管损伤发生率最高,为1.9 1%;其次为术后复发,复发率为1.76%,其中有1例7次手术仍复发病例,5例复发者经OK-432囊内注射愈痊.结论:舌下腺切除术术中术后的规范处理可有效防止严重并发症的发生,可作为舌下腺囊肿的基础治疗方法,低复发率仍为其优点,与OK-432囊内注射结合,可有效防止术后的复发.

  3. 大棚菜农腰痛危险因素的结构方程模型分析

    Institute of Scientific and Technical Information of China (English)

    董红运; 杨曦伟; 于素芳



  4. Development of a dense SNP-based linkage map of an apple rootstock progeny using the Malus Infinium whole genome genotyping array

    Directory of Open Access Journals (Sweden)

    Antanaviciute Laima


    Full Text Available Abstract Background A whole-genome genotyping array has previously been developed for Malus using SNP data from 28 Malus genotypes. This array offers the prospect of high throughput genotyping and linkage map development for any given Malus progeny. To test the applicability of the array for mapping in diverse Malus genotypes, we applied the array to the construction of a SNP-based linkage map of an apple rootstock progeny. Results Of the 7,867 Malus SNP markers on the array, 1,823 (23.2% were heterozygous in one of the two parents of the progeny, 1,007 (12.8% were heterozygous in both parental genotypes, whilst just 2.8% of the 921 Pyrus SNPs were heterozygous. A linkage map spanning 1,282.2 cM was produced comprising 2,272 SNP markers, 306 SSR markers and the S-locus. The length of the M432 linkage map was increased by 52.7 cM with the addition of the SNP markers, whilst marker density increased from 3.8 cM/marker to 0.5 cM/marker. Just three regions in excess of 10 cM remain where no markers were mapped. We compared the positions of the mapped SNP markers on the M432 map with their predicted positions on the ‘Golden Delicious’ genome sequence. A total of 311 markers (13.7% of all mapped markers mapped to positions that conflicted with their predicted positions on the ‘Golden Delicious’ pseudo-chromosomes, indicating the presence of paralogous genomic regions or mis-assignments of genome sequence contigs during the assembly and anchoring of the genome sequence. Conclusions We incorporated data for the 2,272 SNP markers onto the map of the M432 progeny and have presented the most complete and saturated map of the full 17 linkage groups of M. pumila to date. The data were generated rapidly in a high-throughput semi-automated pipeline, permitting significant savings in time and cost over linkage map construction using microsatellites. The application of the array will permit linkage maps to be developed for QTL analyses in a

  5. 中国闭角型青光眼病一家系MYOC和CYP1B1基因两突变分析%Two variants in MYOC and CYP1B1 genes in a Chinese family with primary angle-closure glaucoma

    Institute of Scientific and Technical Information of China (English)

    代小华; 聂尚武; 柯铁; 刘剑萍; 王擎; 刘木根


    Objective To describe the clinical and genetic characteristics of a Chinese family with primary an gle-closure glaucoma (PACG). Methods Linkage analysis and DNA sequencing as well as single strand conformtion polymorphism (SSCP) analysis were performed to identity the disease-causing mutations. Results The Arg46Stop mu tation in MYOC gene and Leu432Val in CYP1B1 gene were identified in all patients. The digenic alterations have not been identified in any same Chinese control individuals. Conclusion Author identified digenic mutations, Arg46Stop in MYOC gene and Leu432Val in CYP1B1 gene, in a Chinese PACG family. Author's studies suggest a possible role of MYOC and CYP1B1 in the development of PACG and support the hypothesis that PAOG and PACG may have common origin across multiple glaucoma phenotypes.%目的 对一个中国闭角型青光眼病家系进行分子遗传学研究.方法 对家系进行连锁分析,通过测序和单链构象多态性方法鉴定致病基因突变.结果 在家系患者中均发现MYOC基因的一个无义突变(Arg46Stop)以及CYP1B1基因的一个氨基酸改变(Leu432Val).而在无亲缘关系的健康中国汉族人群中没有检测到同时存在上述突变.结论 在一个闭角型青光眼病家系内鉴定了MYOC基因突变以及CYP1B1基因多态.该研究结果提示闭角型青光眼病的发病机制可能是二者协同作用的结果,并支持开角和闭角型青光眼病可能存在相同的发病机理的假说.

  6. Association of CYP1B1 gene polymorphisms with susceptibility to endometrial cancer: a meta-analysis. (United States)

    Wang, Fang; Zou, Yan-Feng; Sun, Guo-Ping; Su, Hong; Huang, Fen


    The objective of this meta-analysis was to quantitatively summarize the association of CYP1B1 gene polymorphisms and endometrial cancer risk. Data were collected from the following electronic databases: PubMed,Elsevier Science Direct, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure and Wanfang, with the last report up to June 2010. Meta-analysis was conducted in a fixed/random effect model. Out of the 715 papers retrieved 12 studies (3605 cases and 5692 controls) on the association of CYP1B1 gene polymorphisms with endometrial cancer risk in different ethnic groups were identified. Meta-analysis was performed for CYP1B1 gene polymorphisms: R48G (C/G, five studies), L432V (C/G, 12 studies), N453S (A/G, four studies), and A119S (G/T, five studies). We did not detect any association of CYP1B1 gene A119S polymorphism with endometrial cancer. An association of CYP1B1 gene R48G polymorphism with endometrial cancer was found [GG vs. GC+CC: odds ratio (OR)=0.55, 95% confidence interval (CI): 0.42-0.73, PCYP1B1 gene L432V polymorphism was associated with a significantly increased risk of endometrial cancer (G vs. C: OR=1.23, 95% CI: 1.06-1.43, P=0.007; GC+GG vs. CC:OR=1.24, 95% CI: 1.08-1.43, P=0.003; GC vs. CC: OR=1.16, 95% CI: 1.04-1.29, P=0.009). Moreover, we detected the association of CYP1B1 gene N453S polymorphism with endometrial cancer (G vs. A: OR=0.82,95% CI: 0.72-0.94, P=0.005; GA vs. AA: OR=0.81, 95% CI: 0.69-0.95, P=0.01). In conclusion, this meta-analysis provides strong evidence that CYP1B1 gene R48G, L432V, and N453S polymorphisms are associated with endometrial cancer risk, but not A119S.

  7. Brain cancer and pesticide relationship in orchard farmers of Kashmir

    Directory of Open Access Journals (Sweden)

    Bhat Abdul


    Full Text Available Background: The increasing trend in the incidence of primary malignant brain tumors in orchard farmers and their families in Kashmir. Aim: To determine the relationship between the patients of primary malignant brain tumors and their occupation. Materials and Methods: Retrospectively, case files along with death certificates of 432 patients of primary malignant brain tumors and 457 controls (non-tumor neurologic diseases, admitted for treatment simultaneously over a period of 4 years from January 2005 to December 2008, to the Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences (SKIMS, Kashmir, were studied. Follow-up and family interaction was established. Results: Analysis revealed that 90.04% (389 out of 432 patients were orchard farm workers, orchard residents and orchard playing children exposed to the high levels of multiple types of neurotoxic and carcinogenic (chlorpyriphos, dimethoate, mancozeb and captan chemicals for more than 10 years [relative risk (RR = 10.6; odds ratio (OR = >10; 95% confidence interval (CI = >25-40]. The 9.96% (43 out of 432 patients were not exposed to pesticides. On the other hand, only 19 patients out of 457 controls had recorded history of pesticide exposure and 438 were unrelated to pesticides. Out of 389 patients, 71.7% (279 out of 389 were males and 28.3% (110 out of 389, including six members of three families, were females (one male child. Conclusion: All orchard-related 389 patients had high-grade tumors as compared to the non-pesticide tumors. Mortality in pesticide-exposed tumors was 12%. The higher or upper-normal levels of serum cholinesterase (AChE were observed in 54.7% (213 out of 389 patients and decreased levels were found in only 45.3% (176 out of 389 orchard-related patients (RR = 19.4; OR = >5; 95% CI = >1-10. Although serum AChE levels were a routine investigation in malignant brain tumors, this was not a routine in other neurological conditions (hospitalized controls. The familial

  8. Effects of antipsychotics on microRNA expression of peripheral blood in schizophrenia patients

    Directory of Open Access Journals (Sweden)

    Xin-yang SUN


    Full Text Available Objective To observe the changes in microRNA (miRNA expression levels in peripheral blood of schizophrenia patients before and after treatment with antipsychotics. Methods Sixty-one consecutive patients with schizophrenia (case group and 62 normal controls (control group hospitalized to the 102nd Hospital of PLA from July 2012 to May 2013 were involved in this study. The relative expression levels of 9 miRNAs (miR-181b, miR-195, miR-132, miR-212, miR-30e, miR-346, miR-34a, miR-432, miR-7 in the peripheral blood plasma of patients in two groups were determined by real-time fluorescence quantitative PCR. Twenty-five schizophrenia patients with total score of Positive and Negative Syndrome Scale (PANSS >70 were selected to determine the miRNA expression levels before and 3 and 6 weeks after antipsychotics (including olanzapine, quetiapine, ziprasidone and risperidone treatment, and the clinical symptoms and treatment effect in different stages of therapy were assessed by PANSS, Global Assessment Scale (GAS, and Clinical Global Impression scale (CGI. Results The expression levels of miR-181b, miR-30e, miR-346, miR-34a and miR-7 in case group were significantly higher than those in control group (P70, the expression level of miR-132 lowered 3 weeks after treatment (P0.05. The expression of miR-132, miR-195, miR-30e and miR-432 were significantly correlated with the PANSS total score and GAS score along with the treatment course (P<0.05. Conclusion The miR-181b, miR-132, miR-30e and miR-432 may be used as biological markers for the prediction of the prognosis of patients with schizophrenia. DOI: 10.11855/j.issn.0577-7402.2014.12.09

  9. Four Highly Luminous Massive Star Forming Regions in the Norma Spiral Arm II. Deep NIR imaging

    CERN Document Server

    Chavarria, L; Garay, G; Escala, A; Bronfman, L; Lizano, S


    We present sensitive NIR (J, H and K) imaging observations toward four luminous massive star forming regions in the Norma Spiral Arm: G324.201+0.119, G328.307+0.432, G329.337+0.147 and G330.949-0.174. We identify three clusters of young stellar objects (YSO) based on surface density diagnostics. We also find that sources detected only in the H and K-bands and with colors corresponding to spectral types earlier than B2, are likely YSOs. We analyze the spatial distribution of stars of different masses and find signatures in two clusters of primordial mass segregation which can't be explained as due to incompleteness effects. We show that dynamic interactions of cluster members with the dense gas from the parent core can explain the observed mass segregation, indicating that the gas plays an important role in the dynamics of young clusters.

  10. Estrategias educativas para fomentar habitos, actitudes y normas referidas a la alimentación en educación infantil


    Fernández Bennàssar, María del Carmen; Pastor Homs, María Inmaculada


    La Constitución Española reconoce como uno de los derechos fundamentales la protección de la salud de los ciudadanos (Art. 43) y establece que compete a los poderes públicos organizar y tutelar la salud pública a través de medidas preventivas y de las prestaciones y servicios necesarios (Art. 43.2), a la vez que fomentarán la educación sanitaria, la educación física y e deporte así como la adecuada utilización del ocio (Art. 43.3). Resulta evidente que existe una relación entre cambio soci...

  11. Domain Modeling: NP_004130.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available .2/NP_004130.2_holo_27-478.pdb blast 34I,38G,39L,41Y,42A,43A,45E,46G,47L,49A,50L,93L,101L,103L,142L,144L,152P,204S,205V,208D,209L,...212Y,213L,216L,223D,232L,236P,243L,245V,277V,279F,286F,289A,290S,293Y,298Y,299L,300N,301F,343V,347P,356L,...360P,361Y,362M,383V,384A,385T,389A,391L,398I,399T,400G,402L,43...2I,436F,439K,440F,443K,444L,448F,450L,451P,452L,455R,456V,458L,476V,478Y PC1 0 ...

  12. Domain Modeling: NP_777592.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available .1/NP_777592.1_holo_26-479.pdb blast 34I,38A,39L,41Y,42G,43V,45A,46G,47M,49M,50I,95L,105A,146L,154P,156L,206E,207V,210L,213N,214L,...217L,224D,237P,244L,246L,278L,280I,287F,290A,291S,294H,299V,300F,301N,302V,341I,343A,347P,349I,356F,358L,...360I,361P,362A,383F,384V,385A,389V,390G,391L,398L,399V,400C,402L,404L,432L,436V,437L,...439L,440A,443K,444L,448F,450L,451S,452N,453P,456F,458F,476L,478Y PC1 0 ...

  13. Reseñas de libros


    Pasado y memoria


    Reseñas: ALONSO, Gregorio, La nación en capilla. Ciudadanía católica y cuestión religiosa en España (1793-1874), Granada, Comares Historia, 2014, 376 pp. / Alicia Mira Abad; COLETES BLANCO, Agustín; LASPRA RODRÍGUEZ, Alicia, (eds. y trads.), Libertad frente a Tiranía: Poesía inglesa de la Guerra de la Independencia (1808-1814). Antología Bilingüe, Madrid y Barcelona, Espasa Libros, 2013, 432 pp. / Ignacio Gracia Noriega; BARBASTRO GIL, Luis, El episcopado español y el alto clero en la Guerra ...

  14. Interaction of different irrigation strategies and soil textures on the nitrogen uptake of field grown potatoes

    DEFF Research Database (Denmark)

    Ahmadi, S.H.; Andersen, Mathias Neumann; Lærke, Poul Erik;


    in the loamy sand had the highest amount of N uptake. The interaction between irrigation treatments and soil textures was significant, and implied that under non-limiting water conditions, loamy sand is the suitable soil for potato production because plants can take up sufficient amounts of N and it could......Nitrogen (N) uptake (kg ha-1) of field-grown potatoes was measured in 4.32 m2 lysimeters that were filled with coarse sand, loamy sand, and sandy loam and subjected to full (FI), deficit (DI), and partial root-zone drying (PRD) irrigation strategies. PRD and DI as water-saving irrigation treatments...... received 65% of FI after tuber bulking and lasted for six weeks until final harvest. Results showed that the irrigation treatments were not significantly different in terms of N uptake in the tubers, shoot, and whole crop. However, there was a statistical difference between the soil textures where plants...

  15. Varieties of Quest and the Religious Openness Hypothesis within Religious Fundamentalist and Biblical Foundationalist Ideological Surrounds

    Directory of Open Access Journals (Sweden)

    P. J. Watson


    Full Text Available According to the Religious Openness Hypothesis, the religious and psychological openness of American Christians is obscured by a defensive ghettoization of thought associated with a Religious Fundamentalist Ideological Surround and can be discovered instead within a Biblical Foundationalist Ideological Surround. A test of this claim examined Religious Fundamentalism, Biblical Foundationalism, Quest, and Multidimensional Quest Scales in 432 undergraduates. Christian Religious Reflection, Religious Schema, and Religious Orientation measures clarified these two ideological surrounds. Partial correlations controlling for Biblical Foundationalism described a Religious Fundamentalist Ideological Surround that more strongly rejected Quest and that more generally displayed a failure to integrate faith with intellect. Partial correlations controlling for Religious Fundamentalism revealed a Biblical Foundationalist Ideological Surround that was more open to Quest and that offered numerous demonstrations of an ability to unite faith with intellect. These data supplemented previous investigations in demonstrating that Christianity and other traditional religions have ideological resources for promoting a faithful intellect.

  16. A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study

    Directory of Open Access Journals (Sweden)

    V. P. Diego


    D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (P≈.00001. In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM. We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM. Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.

  17. Fish consumption does not prevent increase in waist circumference in European women and men

    DEFF Research Database (Denmark)

    Jakobsen, Marianne U; Due, Karen M; Dethlefsen, Claus


    fish consumption and subsequent change in waist circumference. Sex, age and waist circumference at enrolment were considered as potential effect modifiers. Women and men (n 89 432) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 5......·5 years. Mixed-effect linear regression was used to investigate the associations between fish consumption and subsequent change in waist circumference. Among all participants, the average annual change in waist circumference was - 0·01 cm/10 g higher total fish consumption per d (95 % CI - 0·01, 0......·00) and - 0·01 cm/10 g higher fatty fish consumption per d (95 % CI - 0·02, - 0·01), after adjustment for potential confounders. Lean fish consumption was not associated with change in waist circumference. Adjustment for potential over- or underestimation of fish consumption measurements did...

  18. Studies on the chemical constituents of essential oil from Zanthoxylum bungeanum Maxim rowing in Hancheng, Shanxi%陕西韩城大红袍花椒挥发油化学成分的研究

    Institute of Scientific and Technical Information of China (English)

    王利平; 李占杰



  19. Supramolecular structures constructed from three novel rare earth metal complexes

    Indian Academy of Sciences (India)

    Huaze Dong; Xiaojun Feng; Xia Liu; BiN Zheng; Jianhong Bi; Yan Xue; Shaohua Gou; Yanping Wang


    Three rare earth metal supramolecular complexes, {[Tb(2)4](ClO4)3·2H2O(1), [Eu(2)2(H2O)5] (ClO4)3(2) and [Gd(NO3)3(2)2]·2CH3CH2OH(3) ( 2 = 3-Dimethylamino-1-pyridin-2-yl-propenone), have been synthesized and characterized by elemental analysis, IR and single crystal X-ray diffraction. The crystal structure analysis reveals that the coordination numbers of three complexes (1–3) are 8, 9 and 10, respectively. Three complexes assembled into 3D frameworks based on C-H⋯O, O-H⋯O hydrogen bond linkages.

  20. Synthesis and Characterization of a Novel Cyclomatrix Phosphazene Polymer

    Institute of Scientific and Technical Information of China (English)

    Zhang Teng; Cai Qing; Wu Zhanpeng; Jin Riguang


    Novel phosphazene cyclomatrix network polymers were synthesized via the nucleophilic displacement of activated nitro groups of tri(4-nitrophenoxy)tri(phenoxy)cyclotriphosphazene and hexa(p-nitrophenoxy)cyclotriphosphazene with hydroxyls of bisphenol A.Both monomers and polymers were characterized by Fourier transform infrared spectroscopy,1H nuclear magnetic resonance,and elemental analysis measurements,and their structures were identified.Thermal properties of polymers were investigated using dynamic thermogravimetric analysis in air.The results demonstrated that both cyclomatrix phosphazene polymers 4 and 6 were of excellent thermal stability,and their char yields in air at 800℃ were 45.1 and 43.2%,respectively.According to combustion phenomenon,polymer 4 was supposed to be processed with a good flameretardant property because of its excellent crosslinked structure during pyrolysis or combustion.However,polymer 6 yielded the opposite result.

  1. The diurnal activity, movement and trypanosome infection rates of Glossina fuscipes fuscipes (Diptera: Glossinidae)in Buvuma Island, Lake Victoria, Uganda

    Institute of Scientific and Technical Information of China (English)



    The diurnal activity patterns, trypanosome infection rates and movement of Glossina fuscipes fuscipes(Diptera: Glossinidae) were investigated in Buvuma Island, Lake Victoria, Uganda. Hourly trapping of tsetse flies was undertaken to determine their activity rhythm while a capture-mark-release-recapture method was conducted to assess the movement and dispersal of tsetse flies between lakeshore, hinterland and further inland sites along a transected area. Dissection of tsetse flies was also undertaken to determine the trypanosome infection rates in salivary glands, proboscis and mid-gut. Results indicated a bimodal diurnal activity profile for G. f. fuscipes on the Island, both on the lakeshore and in the hinterland.Movement and dispersal of G. f. fuscipes tsetse flies occurred between lakeshore, hinterland and further inland sites with a greater tendency of flies to move to the lakeshore. Trypanosome infection rates of 4.32% for Trypasoma vivax and 1.15% for T. congolense were found in G. f. fuscipes.

  2. 肠聚集大肠埃希菌在瑞士腹泻和无腹泻儿童中的流行

    Institute of Scientific and Technical Information of China (English)

    张健; 侯天文


    @@ 引起腹泻的大肠埃希菌可分为6种,包括肠聚集大肠埃希菌(enteroadherent escherichia coli,EAEC)、肠出血性大肠埃希菌(EHEC)、肠致病性大肠埃希菌(enterophathogenic escherichia coli,EPEC)、肠产毒性大肠埃希菌(enterotoxin of escherichia coli,ETEC)、肠侵袭性大肠埃希菌(enteroinvasive escherichia coli,EIEC)和弥散性粘附大肠埃希菌.EAEC作为儿童腹泻源的重要性仍有争论,本文采用PCR方法检测EAEC的质粒pCVD432,从而判定EAEC在瑞士腹泻儿童中的重要性.

  3. Group Theory of Circular-Polarization Effects in Chiral Photonic Crystals with Four-Fold Rotation Axes, Applied to the Eight-Fold Intergrowth of Gyroid Nets

    CERN Document Server

    Saba, Matthias; Mecke, Klaus; Gu, Min; Schröder-Turk, Gerd E


    We use group or representation theory and scattering matrix calculations to derive analytical results for the band structure topology and the scattering parameters, applicable to any chiral photonic crystal with body-centered cubic symmetry I432 for circularly-polarised incident light. We demonstrate in particular that all bands along the cubic [100] direction can be identi?ed with the irreducible representations E+/-,A and B of the C4 point group. E+ and E- modes represent the only transmission channels for plane waves with wave vector along the ? line, and can be identi?ed as non-interacting transmission channels for right- (E-) and left-circularly polarised light (E+), respectively. Scattering matrix calculations provide explicit relationships for the transmission and reflectance amplitudes through a ?nite slab which guarantee equal transmission rates for both polarisations and vanishing ellipticity below a critical frequency, yet allowing for ?nite rotation of the polarisation plane. All results are veri?...

  4. Comparing Canadian and American normative scores on the Wechsler Adult Intelligence Scale-Fourth Edition. (United States)

    Harrison, Allyson G; Armstrong, Irene T; Harrison, Laura E; Lange, Rael T; Iverson, Grant L


    Psychologists practicing in Canada must decide which set of normative data to use for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV). The purpose of this study was to compare the interpretive effects of applying American versus Canadian normative systems in a sample of 432 Canadian postsecondary-level students who were administered the WAIS-IV as part of an evaluation for a learning disability, attention-deficit hyperactivity disorder, or other mental health problems. Employing the Canadian normative system yielded IQ, Index, and subtest scores that were systematically lower than those obtained using the American norms. Furthermore, the percentage agreement in normative classifications, defined as American and Canadian index scores within five points or within the same classification range, was between 49% and 76%. Substantial differences are present between the American and Canadian WAIS-IV norms. Clinicians should consider carefully the implications regarding which normative system is most appropriate for specific types of evaluations.

  5. Synthesis and Crystal Structure of N-Methyl-9-(3,4-dimethoxylphenyl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10- decahydroacridine under Microwave Irradiation

    Institute of Scientific and Technical Information of China (English)

    章晓镜; 屠树江; 朱晓彤; 张金鹏; 徐佳宁; 王倩


    The crystal structure of the title compound (C26H33NO4 (C25.68H32.04No.68O4.32, Mr = 419.35)) has been determined by single-crystal X-ray diffraction. The crystal is of triclinic, space P21/c with a = 7.519(2), b = 28.933(5), c = 10.654(3) (A), β = 91.78(2)°, V= 2316.7(7) (A)3, Z = 4, Dc = 1.202 g/cm3,μ = 0.081 mm-1, F(000) = 902, Mr = 423, the final R = 0.0424 and wR = 0.0911. In the structure, the pyridine ring adopts a boat conformation.

  6. LaZn12.37 (1, a zinc-deficient variant of the NaZn13 structure type

    Directory of Open Access Journals (Sweden)

    Igor Oshchapovsky


    Full Text Available The title compound (lanthanum dodecazinc, LaZn12.37 (1, is confirmed to be a nonstoichiometric (zinc-deficient modification of the NaZn13 structure type, in which one Zn atom (Wyckoff site 8b, site symmetry moverline{3} has a fractional site occupancy of 0.372 (11. The other Zn atom (96i, m and the La atom (8a, 432 are fully occupied. The coordination polyhedra of the Zn atoms are distorted icosahedra, whereas the La atoms are surrounded by 24 Zn atoms, forming pseudo-Frank–Kasper polyhedra. Electronic structure calculations indicate that Zn—Zn bonding is much stronger than La—Zn bonding.

  7. Self-Assembly of Two Chiral Supramolecules with Three-Dimensional Porous Host Frameworks: (Delta){[Fe(II)(phen)(3)][Fe(III)Na(C(2)O(4))(3)]}(n)() and Its Enantiomer. (United States)

    Li, Pei-zhou; Lu, Xiao-ming; Liu, Bo; Wang, Shuo; Wang, Xiao-jun


    Two chiral supramolecules with enantiomeric three-dimensional porous host frameworks, (Delta){[Fe(II)(phen)(3)][Fe(III)Na(C(2)O(4))(3)]}(n) (1) and (Lambda){[Fe(II)(phen)(3)][Fe(III)Na(C(2)O(4))(3)]}(n) (2) (phen = 1,10-phenanthroline), have been synthesized, and their crystal structures have been determined. The structural analysis shows that compounds 1 and 2 are a pair of enantiomers, both consisting of a three-dimensional porous skeleton formed by (Delta)/(Lambda){[Fe(III)Na(C(2)O(4))(3)](2-)}(n) and guest (Delta)/(Lambda)[Fe(phen)(3)](2+) units. The circular dichroism spectrum measurements confirmed the optical activity and the enantiomeric nature of complexes 1 and 2.

  8. Dicty_cDB: VSD141 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VS (Link to library) VSD141 (Link to dictyBase) - - - Contig-U12568-1 VSD141P (Link to Original site) VSD1...41F 203 VSD141Z 229 VSD141P 432 - - Show VSD141 Library VS (Link to library) Clone ID VSD1... URL Representative seq. ID VSD1...41P (Link to Original site) Representative DNA sequence >VSD141 (VSD141Q) /CSM/VS/VSD1-B/VSD1...kfsgkhvifiaq Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value VSD141 (VSD141Q) /CSM/VS/VSD1

  9. Radon levels and doses in dwellings in two villages in Kosovo, affected by depleted uranium. (United States)

    Nafezi, G; Gregoric, A; Vaupotic, J; Bahtijari, M; Kuqali, M


    The radon ((222)Rn) activity concentration in 15 dwellings in the Planej village and 10 dwellings in the Gorozhup village has been measured with the aim to complement the national radon survey and to compare the results of two different measurement techniques. The radon concentration has been measured in winter and spring using alpha scintillation cells and in winter, spring and summer by exposing solid-state nuclear track detectors. Both methods gave similar results. Radon concentrations in both villages were similar, ranging from 82 to 432 Bq m(-3); the value of 400 Bq m(-3) was exceeded only in two dwellings. The resulting annual effective doses ranged from 1.78 to 6.40 mSv, with the average values of 3.28 mSv in the Planej village and 3.87 mSv in the Gorozhup village.

  10. Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet

    DEFF Research Database (Denmark)

    Krogholm, Kirstine Suszkiewicz; Bredsdorff, Lea; Knuthsen, Pia


    The bioavailability and urinary excretion of three dietary flavonoids, quercetin, hesperetin and naringenin, were investigated. Ten healthy men were asked to consume a 'juice mix' containing equal amounts of the three flavonoids, and their urine and plasma samples were collected. The resulting mean...... plasma area under the curve (AUC)(0-48h) and C-max values for quercetin and hesperetin were similar, whereas the AUC(0-48h) of naringenin and, thus, the relative bioavailability were higher after consumption of the same dose. The study consolidates a significantly lower urinary excretion of quercetin (1.......5 +/- 1%) compared with hesperetin (14.2 +/- 9.1%) and naringenin (22.6 +/- 11.5%) and shows that this is not due to a lower bioavailability of quercetin, but rather reflects different clearance mechanisms. European Journal of Clinical Nutrition (2010) 64, 432-435; doi: 10.1038/ejcn.2010.6; published...

  11. 垂体泌乳素腺瘤组织中相关microRNA的表达%Differential expression analysis of prolactinoma-related microRNAs

    Institute of Scientific and Technical Information of China (English)

    陈云祥; 李强; 王成德; 苏志鹏; 李伟强; 陈贤斌; 吴哲褒


    Objective To explore the relationship between the prolactinoma-related microRNAs (miRNA) and the development,growth and hormone secretion of prolactinoma.Methods The technique of Solexa sequencing was employed to analyze the differential expressions of prolactinoma and normal anterior pituitary gland samples. And the stem-loop real-time polymerase chain reaction (PCR) was utilized for confirmation.Results According to the differentially expressed profiles of miRNAs,4 miRNAs were downregulated (miR-130a,miR-199b-3p,miR-200b,miR-125b,P<0.05) and6 miRNAs up-regulated (miR-342-3p,miR-432,miR-23b,miR-493,miR-493 *,miR-664 *,P < 0.05).The expression levels of miR-493 * and miR-432 had a significant positive correlation with the serum level of prolactin ( r =0.47,P <0.05 ; r =0.528,P < 0.01 ) while miR-342-3p a significantly positive correlation with the invasiveness ( r =0.402,P < 0.05 ).Conclusion miRNAs are differentially expressed between normal anterior pituitary gland and prolactinomas,between invasive and localized prolactinomas and among different hormone secretion levels. It suggests that miRNAs may be involved in the physiological process of development,growth and hormone secretion of prolactinoma.%目的 探讨垂体泌乳素(PRL)腺瘤组织中的microRNA(miRNA)表达与腺瘤形成、生长及激素分泌的关系.方法 利用Slexa测序技术分析miRNA在PRL腺瘤和正常垂体前叶组织中的差异表达,并用茎环引物(stem-loop) RT-PCR技术在27例PRL腺瘤和5例正常垂体前叶中加以验证.结果 通过Solexa测序对比PRL腺瘤与正常垂体前叶组织,发现39个丰度较高的miRNA存在差异性表达.进一步通过stem-loop RT-PCR验证,发现4个miRNA下调(miR-130a,miR-199b-3p,miR-200b,miR-125b,P<0.05);6个miRNA上调(miR-342-3p,miR-432,miR-23b,miR-493,miR-493*,miR-664*,P<0.05).其中miR-493*,miR-432表达与泌乳素水平呈显著正相关(r=0.47,P<0.05;r=0.528,P<0.01);miR-342-3p表达与

  12. Treatment with intravenous thrombolysis in acute ischemic stroke is associated with reduced bed day use

    DEFF Research Database (Denmark)

    Terkelsen, Thorkild; Schmitz, Marie Louise; Simonsen, Claus Z.;


    for hospital admissions during follow-up. Methods: We conducted a register-based nationwide propensity score-matched follow-up study among ischemic stroke patients in Denmark (2004-2011). IV-tPA-treated patients were propensity-score matched with IV-tPA eligible but non-treated ischemic stroke patients from...... follow-up time of at least one year and was compared between groups by a paired t-test after logarithmic transformation. Results: We identified 1896 IV-tPA-treated and 1896 corresponding propensity-score matched non-treated patients surviving the initial stroke admission. A total of 43.2% of the patients...

  13. Analisis Perbedaan Efektivitas Organisasi ditinjau dari Kesesuaian, Kekuatan, dan Tipe Budaya

    Directory of Open Access Journals (Sweden)

    Retno hartati


    Full Text Available Abstract This study aims to identify and analyze how much influence the effectiveness of the organization’s culture is viewed from the standpoint of suitability, strength and type of culture in Higher Education institutions. Respondents in this study were 150 structural officials from 40 universities in Indonesia, which is taken by using purposive sampling method. The analysis shows that the three cultural variables have different influence on the effectiveness. Variable types of culture (especially Adhocracy culture is seen to have the highest impact on the effectiveness of variables (scores F: 52 577, sign 0.000, compared with the strength of the cultural variables (scores F: 37 197, sign 0.000, and the variables that influence the cultural appropriateness minimum (no effect on the effectiveness (scores F: .620, .432 sign

  14. A psychometric analysis of the Trait Emotional Intelligence Questionnaire-Short Form (TEIQue-SF) using item response theory. (United States)

    Cooper, Andrew; Petrides, K V


    Trait emotional intelligence refers to a constellation of emotional self-perceptions located at the lower levels of personality hierarchies. In 2 studies, we sought to examine the psychometric properties of the Trait Emotional Intelligence Questionnaire-Short Form (TEIQue-SF; Petrides, 2009) using item response theory (IRT). Study 1 (N= 1,119, 455 men) showed that most items had good discrimination and threshold parameters and high item information values. At the global level, the TEIQue-SF showed very good precision across most of the latent trait range. Study 2 (N= 866, 432 men) used similar IRT techniques in a new sample based on the latest version of the TEIQue-SF (version 1.50). Results replicated Study 1, with the instrument showing good psychometric properties at the item and global level. Overall, the 2 studies suggest the TEIQue-SF can be recommended when a rapid assessment of trait emotional intelligence is required.

  15. La enfermedad del siglo XXI y la calidad de vida en adultos mayores de Tarapoto

    Directory of Open Access Journals (Sweden)

    Renzo Carranza

    Full Text Available Every day is interesting to observe that the aging of the global population is increasing and this has led to interest in learning more about the emotions as well as the quality of life of older people. The aim of this study was to determine to what extent are related depression and quality of life in older adults Huayco Health Center - Tarapoto. We used a non-experimental, descriptive correlational. Instruments: Beck Depression Inventory (BDI-II consists of 21 items and Comprehensive Evaluation Form Senior Ministry of Health (Quality of Life section, consisting of 33 items. The psychometric properties of the instruments indicated that are valid and reliable. The results show that there is a highly significant negative relationshipbetween depression and quality of life (r = - 0.432, p <.01. This means that, how much more can be the depression then quality of life will be affected

  16. Algogenic substances and metabolic status in work-related Trapezius Myalgia

    DEFF Research Database (Denmark)

    Gerdle, Björn; Kristiansen, Jesper; Larsson, Britt


    BACKGROUND: This study compares the levels of algesic substances between subjects with trapezius myalgia (TM) and healthy controls (CON) and explores the multivariate correlation pattern between these substances, pain, and metabolic status together with relative blood flow changes reported in our......, metabolite accumulation, oxygenation, and pain development and sensitivity. RESULTS: Substance P was significantly elevated in TM (p=0.0068). No significant differences were found in the classical algesic substances (p: 0.432-0.926). The multivariate analysis showed that blood flow related variables...... (LDH), substance P, and N-terminal propeptide of procollagen type I (PINP) in the trapezius muscle at rest and during repetitive/stressful work. These data were also used in multivariate analyses together with previously presented data (Eur J Appl Physiol 108:657-669, 2010): trapezius muscle blood flow...

  17. Dicty_cDB: SFC551 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SF (Link to library) SFC551 (Link to dictyBase) - - - Contig-U10682-1 SFC551P (Link to Original site) SFC...551F 432 SFC551Z 493 SFC551P 925 - - Show SFC551 Library SF (Link to library) Clone ID SFC... URL Representative seq. ID SFC...551P (Link to Original site) Representative DNA sequence >SFC551 (SFC551Q) /CSM/SF/SFC5-C/SFC5...yg*ridg*--- ---igyhhf*ivkw*npirw**skydf*knh*lyk*nkfsilff*scn*fnskiitsrsi keirckwc**s*ktsil*wskle*nlfsrifdiqaknrk*i*fqlff*krkc*knsfc


    Institute of Scientific and Technical Information of China (English)

    Yi Xiao; Xu Zhong; Rong Huang


    Objective To evaluate the feasibility of pulse transit time ( PIT) arousals as an index of sleep fragmentation in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Individuals referred for evaluation of possible OSAHS underwent overnight polysomnography (PSG). Three conventional indices of sleep fragmentation [ electroencephalography (EEG) arousals, apnea/hypopnea index (AMI), oxygen desaturation index (ODI) ], PTT arousals, and Epworth sleepiness scale (ESS) were compared.Results PTT arousals were positively correlated with EEG arousals (r = 0.746, P<0. 001), AHI (r = 0.786, P< 0. 001) , and ODI (r = 0. 665, P<0. 001), respectively. But, both PTT arousals and EEG arousals had no correlation with ESS O= 0.432, P=0.201; r= 0.196, P=0.59l, respectively).Conclusion PTT arousals are correlated well with other standard measures estimating severity of OSAHS and potentially a non-invasive marker with which to measure the sleep fragmentation in patients with OSAHS.

  19. High harmonic phase in molecular nitrogen

    Energy Technology Data Exchange (ETDEWEB)

    McFarland, Brian K.


    Electronic structure in atoms and molecules modulates the amplitude and phase of high harmonic generation (HHG). We report measurements of the high harmonic spectral amplitude and phase in N{sub 2}. The phase is measured interferometrically by beating the N{sub 2} harmonics with those of an Ar reference oscillator in a gas mixture. A rapid phase shift of 0.2{pi} is observed in the vicinity of the HHG spectral minimum, where a shift of {pi} had been presumed [J. Itatani et al., Nature 432, 867 (2004)]. We compare the phase measurements to a simulation of the HHG recombination step in N{sub 2} that is based on a simple interference model. The results of the simulation suggest that modifications beyond the simple interference model are needed to explain HHG spectra in molecules.

  20. Investigating the energy harvesting capabilities of a hybrid ZnO nanowires/carbon fiber polymer composite beam. (United States)

    Masghouni, N; Burton, J; Philen, M K; Al-Haik, M


    Hybrid piezoelectric composite structures that are able to convert mechanical energy into electricity have gained growing attention in the past few years. In this work, an energy harvesting composite beam is developed by growing piezoelectric zinc oxide nanowires on the surface of carbon fiber prior to forming structural composites. The piezoelectric behavior of the composite beam was demonstrated under different vibration sources such as water bath sonicator and permanent magnet vibration shaker. The beam was excited at its fundamental natural frequency (43.2 Hz) and the open circuit voltage and the short circuit current were measured to be 3.1 mV and 23 nA, respectively. Upon connecting an optimal resistor (1.2 kΩ) in series with the beam a maximum power output 2.5 nW was achieved.