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Sample records for allostery limit performance

  1. Piezoelectric allostery of protein

    Science.gov (United States)

    Ohnuki, Jun; Sato, Takato; Takano, Mitsunori

    2016-07-01

    Allostery is indispensable for a protein to work, where a locally applied stimulus is transmitted to a distant part of the molecule. While the allostery due to chemical stimuli such as ligand binding has long been studied, the growing interest in mechanobiology prompts the study of the mechanically stimulated allostery, the physical mechanism of which has not been established. By molecular dynamics simulation of a motor protein myosin, we found that a locally applied mechanical stimulus induces electrostatic potential change at distant regions, just like the piezoelectricity. This novel allosteric mechanism, "piezoelectric allostery", should be of particularly high value for mechanosensor/transducer proteins.

  2. Allostery: An Overview of Its History, Concepts, Methods, and Applications.

    Directory of Open Access Journals (Sweden)

    Jin Liu

    2016-06-01

    Full Text Available The concept of allostery has evolved in the past century. In this Editorial, we briefly overview the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect (1904 to the birth of allostery by Monod and Jacob (1961. We describe the evolution of the allostery concept, from a conformational change in a two-state model (1965, 1966 to dynamic allostery in the ensemble model (1999; from multi-subunit (1965 proteins to all proteins (2004. We highlight the current available methods to study allostery and their applications in studies of conformational mechanisms, disease, and allosteric drug discovery. We outline the challenges and future directions that we foresee. Altogether, this Editorial narrates the history of this fundamental concept in the life sciences, its significance, methodologies to detect and predict it, and its application in a broad range of living systems.

  3. A unified view of "how allostery works".

    Directory of Open Access Journals (Sweden)

    Chung-Jung Tsai

    2014-02-01

    Full Text Available The question of how allostery works was posed almost 50 years ago. Since then it has been the focus of much effort. This is for two reasons: first, the intellectual curiosity of basic science and the desire to understand fundamental phenomena, and second, its vast practical importance. Allostery is at play in all processes in the living cell, and increasingly in drug discovery. Many models have been successfully formulated, and are able to describe allostery even in the absence of a detailed structural mechanism. However, conceptual schemes designed to qualitatively explain allosteric mechanisms usually lack a quantitative mathematical model, and are unable to link its thermodynamic and structural foundations. This hampers insight into oncogenic mutations in cancer progression and biased agonists' actions. Here, we describe how allostery works from three different standpoints: thermodynamics, free energy landscape of population shift, and structure; all with exactly the same allosteric descriptors. This results in a unified view which not only clarifies the elusive allosteric mechanism but also provides structural grasp of agonist-mediated signaling pathways, and guides allosteric drug discovery. Of note, the unified view reasons that allosteric coupling (or communication does not determine the allosteric efficacy; however, a communication channel is what makes potential binding sites allosteric.

  4. Chromatin fiber allostery and the epigenetic code

    Science.gov (United States)

    Lesne, Annick; Foray, Nicolas; Cathala, Guy; Forné, Thierry; Wong, Hua; Victor, Jean-Marc

    2015-02-01

    The notion of allostery introduced for proteins about fifty years ago has been extended since then to DNA allostery, where a locally triggered DNA structural transition remotely controls other DNA-binding events. We further extend this notion and propose that chromatin fiber allosteric transitions, induced by histone-tail covalent modifications, may play a key role in transcriptional regulation. We present an integrated scenario articulating allosteric mechanisms at different scales: allosteric transitions of the condensed chromatin fiber induced by histone-tail acetylation modify the mechanical constraints experienced by the embedded DNA, thus possibly controlling DNA-binding of allosteric transcription factors or further allosteric mechanisms at the linker DNA level. At a higher scale, different epigenetic constraints delineate different statistically dominant subsets of accessible chromatin fiber conformations, which each favors the assembly of dedicated regulatory complexes, as detailed on the emblematic example of the mouse Igf2-H19 gene locus and its parental imprinting. This physical view offers a mechanistic and spatially structured explanation of the observed correlation between transcriptional activity and histone modifications. The evolutionary origin of allosteric control supports to speak of an ‘epigenetic code’, by which events involved in transcriptional regulation are encoded in histone modifications in a context-dependent way.

  5. Allostery through protein-induced DNA bubbles.

    Science.gov (United States)

    Traverso, Joseph J; Manoranjan, Valipuram S; Bishop, A R; Rasmussen, Kim Ø; Voulgarakis, Nikolaos K

    2015-01-01

    Allostery through DNA is increasingly recognized as an important modulator of DNA functions. Here, we show that the coalescence of protein-induced DNA bubbles can mediate allosteric interactions that drive protein aggregation. We propose that such allostery may regulate DNA's flexibility and the assembly of the transcription machinery. Mitochondrial transcription factor A (TFAM), a dual-function protein involved in mitochondrial DNA (mtDNA) packaging and transcription initiation, is an ideal candidate to test such a hypothesis owing to its ability to locally unwind the double helix. Numerical simulations demonstrate that the coalescence of TFAM-induced bubbles can explain experimentally observed TFAM oligomerization. The resulting melted DNA segment, approximately 10 base pairs long, around the joints of the oligomers act as flexible hinges, which explains the efficiency of TFAM in compacting DNA. Since mitochondrial polymerase (mitoRNAP) is involved in melting the transcription bubble, TFAM may use the same allosteric interaction to both recruit mitoRNAP and initiate transcription.

  6. Allostery through protein-induced DNA bubbles

    Science.gov (United States)

    Traverso, Joseph J.; Manoranjan, Valipuram S.; Bishop, A. R.; Rasmussen, Kim Ø.; Voulgarakis, Nikolaos K.

    2015-03-01

    Allostery through DNA is increasingly recognized as an important modulator of DNA functions. Here, we show that the coalescence of protein-induced DNA bubbles can mediate allosteric interactions that drive protein aggregation. We propose that such allostery may regulate DNA's flexibility and the assembly of the transcription machinery. Mitochondrial transcription factor A (TFAM), a dual-function protein involved in mitochondrial DNA (mtDNA) packaging and transcription initiation, is an ideal candidate to test such a hypothesis owing to its ability to locally unwind the double helix. Numerical simulations demonstrate that the coalescence of TFAM-induced bubbles can explain experimentally observed TFAM oligomerization. The resulting melted DNA segment, approximately 10 base pairs long, around the joints of the oligomers act as flexible hinges, which explains the efficiency of TFAM in compacting DNA. Since mitochondrial polymerase (mitoRNAP) is involved in melting the transcription bubble, TFAM may use the same allosteric interaction to both recruit mitoRNAP and initiate transcription.

  7. Allostery in BAX protein activation.

    Science.gov (United States)

    Jiang, Zhenyan; Zhang, Hansi; Böckmann, Rainer A

    2016-11-01

    BAX is a member of the proapoptotic BCL-2 family of proteins, which is involved in the regulation of the intrinsic pathway of apoptosis. In the process of apoptosis, BH3-only molecules activate cytosolic BAX. Activated BAX molecules insert into the mitochondrial outer membrane with their [Formula: see text]-helix and form oligomers that lead to membrane poration, resulting in the release of apoptogenic factors including cytochrome c. Recently, a novel interaction site for the binding of the BIM SAHB ligand to BAX was reported. BIM SAHB binding was shown to invoke the exposure of the 6A7 epitope (amino acids 13-19) and of the BH3 domain of BAX, followed by mobilization of the BAX [Formula: see text]-helix. However, the intramolecular pathway for signal transmission in BAX, from BIM SAHB binding to mobilization of the [Formula: see text]-helix largely remained elusive. For a molecular understanding of the activation of BAX, and thus the first steps in apoptosis, we performed microsecond atomistic molecular dynamics simulations both of the BAX protein and of the BAX:BIM SAHB complex in aqueous solution. In agreement with experiment, the 6A7 and BH3 domains adopt a more solvent-exposed conformation within the BAX:BIM SAHB complex. BIM SAHB binding was found to stabilize the secondary structure of the [Formula: see text]9-helix. A force distribution analysis revealed a force network of residue-residue interactions responsible for signal transmission from the BIM SAHB binding site predominantly via the [Formula: see text]4- and [Formula: see text]6-helices to the [Formula: see text]9-helix on the opposite site of the protein.

  8. The limits of human performance.

    Science.gov (United States)

    Beneke, Ralph; Böning, Dieter

    2008-01-01

    Human performance, defined by mechanical resistance and distance per time, includes human, task and environmental factors, all interrelated. It requires metabolic energy provided by anaerobic and aerobic metabolic energy sources. These sources have specific limitations in the capacity and rate to provide re-phosphorylation energy, which determines individual ratios of aerobic and anaerobic metabolic power and their sustainability. In healthy athletes, limits to provide and utilize metabolic energy are multifactorial, carefully matched and include a safety margin imposed in order to protect the integrity of the human organism under maximal effort. Perception of afferent input associated with effort leads to conscious or unconscious decisions to modulate or terminate performance; however, the underlying mechanisms of cerebral control are not fully understood. The idea to move borders of performance with the help of biochemicals is two millennia old. Biochemical findings resulted in highly effective substances widely used to increase performance in daily life, during preparation for sport events and during competition, but many of them must be considered as doping and therefore illegal. Supplements and food have ergogenic potential; however, numerous concepts are controversially discussed with respect to legality and particularly evidence in terms of usefulness and risks. The effect of evidence-based nutritional strategies on adaptations in terms of gene and protein expression that occur in skeletal muscle during and after exercise training sessions is widely unknown. Biochemical research is essential for better understanding of the basic mechanisms causing fatigue and the regulation of the dynamic adaptation to physical and mental training.

  9. Performance limits of heliostat fields

    Energy Technology Data Exchange (ETDEWEB)

    Kribus, A.; Krupkin, V.; Yogev, A. [Weizmann Inst. of Science, Rehovot (Israel). Environmental Sciences and Energy Research Dept.; Spirkl, W. [Ludwig-Maximilians-Univ. Muenchen (Germany). Sektion Physik

    1998-11-01

    Geometric and thermodynamic arguments are used to derive upper limits on the performance of a solar energy collection system, consisting of an axisymmetric heliostat field, a solar tower, secondary optics and a black receiver. Performance limits on collected power, concentration, and work output are presented. Performance of tower systems with several secondary optics options is compared: tower-top Compound Parabolic Concentrator (CPC), Tailored Edge-Ray Concentrator (TERC) approximated by a cone, and Cassegrainian with ground-level CPC or Compound Elliptic Concentrator (CEC). Optimized ray tracing is used to generate the design parameters of the secondary concentrators that yield the highest optical efficiency. The results show that the tower-top Cone provides the best performance regarding both concentration and efficiency, except for very large fields. The Cassegrainian designs come in second, but become equal and even better than the Cone for large fields. The results for the Cassegrainian are sensitive to the value of the reflectivity, due to the additional reflections incurred. The choice of a CEC is better than a CPC for the terminal concentration in a Cassegrainian system, but the difference is small. The suitability of the different design options for high-temperature solar applications is discussed. The recommendations regarding optical configuration depend on field size, as well as on application-specific constraints.

  10. The allostery landscape: quantifying thermodynamic couplings in biomolecular systems

    CERN Document Server

    Cuendet, Michel A; LeVine, Michael V

    2016-01-01

    Allostery plays a fundament role in most biological processes. However, little theory is available to describe it outside of two-state models. Here we use a statistical mechanical approach to show that the allosteric coupling between two collective variables is not a single number, but instead a two-dimensional thermodynamic coupling function that is directly related to the mutual information from information theory and the copula density function from probability theory. On this basis, we demonstrate how to quantify the contribution of specific energy terms to this thermodynamic coupling function, enabling a decomposition that reveals the mechanism of allostery. We illustrate the thermodynamic coupling function and its use by showing how allosteric coupling in the alanine dipeptide molecule contributes to the overall shape of the {\\Phi}/{\\Psi} free energy surface, and by identifying the interactions that are necessary for this coupling.

  11. Performance limitations of relay neurons.

    Directory of Open Access Journals (Sweden)

    Rahul Agarwal

    Full Text Available Relay cells are prevalent throughout sensory systems and receive two types of inputs: driving and modulating. The driving input contains receptive field properties that must be transmitted while the modulating input alters the specifics of transmission. For example, the visual thalamus contains relay neurons that receive driving inputs from the retina that encode a visual image, and modulating inputs from reticular activating system and layer 6 of visual cortex that control what aspects of the image will be relayed back to visual cortex for perception. What gets relayed depends on several factors such as attentional demands and a subject's goals. In this paper, we analyze a biophysical based model of a relay cell and use systems theoretic tools to construct analytic bounds on how well the cell transmits a driving input as a function of the neuron's electrophysiological properties, the modulating input, and the driving signal parameters. We assume that the modulating input belongs to a class of sinusoidal signals and that the driving input is an irregular train of pulses with inter-pulse intervals obeying an exponential distribution. Our analysis applies to any [Formula: see text] order model as long as the neuron does not spike without a driving input pulse and exhibits a refractory period. Our bounds on relay reliability contain performance obtained through simulation of a second and third order model, and suggest, for instance, that if the frequency of the modulating input increases or the DC offset decreases, then relay increases. Our analysis also shows, for the first time, how the biophysical properties of the neuron (e.g. ion channel dynamics define the oscillatory patterns needed in the modulating input for appropriately timed relay of sensory information. In our discussion, we describe how our bounds predict experimentally observed neural activity in the basal ganglia in (i health, (ii in Parkinson's disease (PD, and (iii in PD during

  12. The limits of human athletic performance.

    Science.gov (United States)

    Maughan, R J

    2005-01-01

    For each individual, there is a limit to the capacity to perform exercise. The limitation, however, depends on the nature of the task and is also influenced by a number of other factors. Muscle strength is determined largely by muscle mass, specifically muscle cross-sectional area, but is also influenced by neural drive and biomechanical factors. Endurance performance depends on both cardiovascular capacity and the metabolic characteristics of the skeletal muscles. These factors are determined in part by genetic endowment: the elite sprinter has a high proportion of Type 2 muscle fibres while the leg muscles of the successful marathon runner are composes mainly of Type 1 fibres. Whatever the genetic potential, expression of this depends on the intensity, duration and frequency of the applied training stimulus, diet and other factors. The limitation may also depend on environmental factors, such as altitude and temperature.

  13. Relaxation dispersion NMR spectroscopy for the study of protein allostery.

    Science.gov (United States)

    Farber, Patrick J; Mittermaier, Anthony

    2015-06-01

    Allosteric transmission of information between distant sites in biological macromolecules often involves collective transitions between active and inactive conformations. Nuclear magnetic resonance (NMR) spectroscopy can yield detailed information on these dynamics. In particular, relaxation dispersion techniques provide structural, dynamic, and mechanistic information on conformational transitions occurring on the millisecond to microsecond timescales. In this review, we provide an overview of the theory and analysis of Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion NMR experiments and briefly describe their application to the study of allosteric dynamics in the homeodomain from the PBX transcription factor (PBX-HD). CPMG NMR data show that local folding (helix/coil) transitions in one part of PBX-HD help to communicate information between two distant binding sites. Furthermore, the combination of CPMG and other spin relaxation data show that this region can also undergo local misfolding, reminiscent of conformational ensemble models of allostery.

  14. Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations.

    Directory of Open Access Journals (Sweden)

    Samuel Hertig

    2016-06-01

    Full Text Available Molecular dynamics (MD simulations have become a powerful and popular method for the study of protein allostery, the widespread phenomenon in which a stimulus at one site on a protein influences the properties of another site on the protein. By capturing the motions of a protein's constituent atoms, simulations can enable the discovery of allosteric binding sites and the determination of the mechanistic basis for allostery. These results can provide a foundation for applications including rational drug design and protein engineering. Here, we provide an introduction to the investigation of protein allostery using molecular dynamics simulation. We emphasize the importance of designing simulations that include appropriate perturbations to the molecular system, such as the addition or removal of ligands or the application of mechanical force. We also demonstrate how the bidirectional nature of allostery-the fact that the two sites involved influence one another in a symmetrical manner-can facilitate such investigations. Through a series of case studies, we illustrate how these concepts have been used to reveal the structural basis for allostery in several proteins and protein complexes of biological and pharmaceutical interest.

  15. Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations.

    Science.gov (United States)

    Hertig, Samuel; Latorraca, Naomi R; Dror, Ron O

    2016-06-01

    Molecular dynamics (MD) simulations have become a powerful and popular method for the study of protein allostery, the widespread phenomenon in which a stimulus at one site on a protein influences the properties of another site on the protein. By capturing the motions of a protein's constituent atoms, simulations can enable the discovery of allosteric binding sites and the determination of the mechanistic basis for allostery. These results can provide a foundation for applications including rational drug design and protein engineering. Here, we provide an introduction to the investigation of protein allostery using molecular dynamics simulation. We emphasize the importance of designing simulations that include appropriate perturbations to the molecular system, such as the addition or removal of ligands or the application of mechanical force. We also demonstrate how the bidirectional nature of allostery-the fact that the two sites involved influence one another in a symmetrical manner-can facilitate such investigations. Through a series of case studies, we illustrate how these concepts have been used to reveal the structural basis for allostery in several proteins and protein complexes of biological and pharmaceutical interest.

  16. Designing allostery-inspired response in mechanical networks

    Science.gov (United States)

    Rocks, Jason W.; Pashine, Nidhi; Bischofberger, Irmgard; Goodrich, Carl P.; Liu, Andrea J.; Nagel, Sidney R.

    2017-01-01

    Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of networks. With nearly complete success, we are able to produce a strain between any two target nodes in a network in response to an applied source strain on any other pair of nodes by removing only ∼1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic 2D and 3D systems that exhibit these responses. This work is inspired by the long-range coupled conformational changes that constitute allosteric function in proteins. The fact that allostery is a common means for regulation in biological molecules suggests that it is a relatively easy property to develop through evolution. In analogy, our results show that long-range coupled mechanical responses are similarly easy to achieve in disordered networks. PMID:28223534

  17. Metabolic factors limiting performance in marathon runners.

    Directory of Open Access Journals (Sweden)

    Benjamin I Rapoport

    Full Text Available Each year in the past three decades has seen hundreds of thousands of runners register to run a major marathon. Of those who attempt to race over the marathon distance of 26 miles and 385 yards (42.195 kilometers, more than two-fifths experience severe and performance-limiting depletion of physiologic carbohydrate reserves (a phenomenon known as 'hitting the wall', and thousands drop out before reaching the finish lines (approximately 1-2% of those who start. Analyses of endurance physiology have often either used coarse approximations to suggest that human glycogen reserves are insufficient to fuel a marathon (making 'hitting the wall' seem inevitable, or implied that maximal glycogen loading is required in order to complete a marathon without 'hitting the wall.' The present computational study demonstrates that the energetic constraints on endurance runners are more subtle, and depend on several physiologic variables including the muscle mass distribution, liver and muscle glycogen densities, and running speed (exercise intensity as a fraction of aerobic capacity of individual runners, in personalized but nevertheless quantifiable and predictable ways. The analytic approach presented here is used to estimate the distance at which runners will exhaust their glycogen stores as a function of running intensity. In so doing it also provides a basis for guidelines ensuring the safety and optimizing the performance of endurance runners, both by setting personally appropriate paces and by prescribing midrace fueling requirements for avoiding 'the wall.' The present analysis also sheds physiologically principled light on important standards in marathon running that until now have remained empirically defined: The qualifying times for the Boston Marathon.

  18. Metamaterial polarization converter analysis: limits of performance

    DEFF Research Database (Denmark)

    Markovich, Dmitry L.; Andryieuski, Andrei; Zalkovskij, Maksim;

    2013-01-01

    In this paper, we analyze the theoretical limits of a metamaterial-based converter with orthogonal linear eigenpolarizations that allow linear-to-elliptical polarization transformation with any desired ellipticity and ellipse orientation. We employ the transmission line approach providing a needed...... and a single layer with a ground plane can have 100 % polarization conversion efficiency. We tested our conclusions numerically reaching the designated limits of efficiency using a simple metamaterial design. Our general analysis provides useful guidelines for the metamaterial polarization converter design...

  19. Order-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase.

    Directory of Open Access Journals (Sweden)

    Mioara Larion

    Full Text Available Glucokinase (GCK catalyzes the rate-limiting step of glucose catabolism in the pancreas, where it functions as the body's principal glucose sensor. GCK dysfunction leads to several potentially fatal diseases including maturity-onset diabetes of the young type II (MODY-II and persistent hypoglycemic hyperinsulinemia of infancy (PHHI. GCK maintains glucose homeostasis by displaying a sigmoidal kinetic response to increasing blood glucose levels. This positive cooperativity is unique because the enzyme functions exclusively as a monomer and possesses only a single glucose binding site. Despite nearly a half century of research, the mechanistic basis for GCK's homotropic allostery remains unresolved. Here we explain GCK cooperativity in terms of large-scale, glucose-mediated disorder-order transitions using 17 isotopically labeled isoleucine methyl groups and three tryptophan side chains as sensitive nuclear magnetic resonance (NMR probes. We find that the small domain of unliganded GCK is intrinsically disordered and samples a broad conformational ensemble. We also demonstrate that small-molecule diabetes therapeutic agents and hyperinsulinemia-associated GCK mutations share a strikingly similar activation mechanism, characterized by a population shift toward a more narrow, well-ordered ensemble resembling the glucose-bound conformation. Our results support a model in which GCK generates its cooperative kinetic response at low glucose concentrations by using a millisecond disorder-order cycle of the small domain as a "time-delay loop," which is bypassed at high glucose concentrations, providing a unique mechanism to allosterically regulate the activity of human GCK under physiological conditions.

  20. The Uses and Limits of Performance Assessment.

    Science.gov (United States)

    Eisner, Elliot W.

    1999-01-01

    Performance assessment can help educators develop ways to reveal individual students' distinctive features and secure information about learning. These opportunities will be wasted unless the public's attitudes and expectations toward schooling are changed. Attitudes cannot change without revising policies inhibiting school children's educational…

  1. The interplay between effector binding and allostery in an engineered protein switch.

    Science.gov (United States)

    Choi, Jay H; Xiong, Tina; Ostermeier, Marc

    2016-09-01

    The protein design rules for engineering allosteric regulation are not well understood. A fundamental understanding of the determinants of ligand binding in an allosteric context could facilitate the design and construction of versatile protein switches and biosensors. Here, we conducted extensive in vitro and in vivo characterization of the effects of 285 unique point mutations at 15 residues in the maltose-binding pocket of the maltose-activated β-lactamase MBP317-347. MBP317-347 is an allosteric enzyme formed by the insertion of TEM-1 β-lactamase into the E. coli maltose binding protein (MBP). We find that the maltose-dependent resistance to ampicillin conferred to the cells by the MBP317-347 switch gene (the switch phenotype) is very robust to mutations, with most mutations slightly improving the switch phenotype. We identified 15 mutations that improved switch performance from twofold to 22-fold, primarily by decreasing the catalytic activity in the absence of maltose, perhaps by disrupting interactions that cause a small fraction of MBP in solution to exist in a partially closed state in the absence of maltose. Other notable mutations include K15D and K15H that increased maltose affinity 30-fold and Y155K and Y155R that compromised switching by diminishing the ability of maltose to increase catalytic activity. The data also provided insights into normal MBP physiology, as select mutations at D14, W62, and F156 retained high maltose affinity but abolished the switch's ability to substitute for MBP in the transport of maltose into the cell. The results reveal the complex relationship between ligand binding and allostery in this engineered switch.

  2. Performance Limits of Communication with Energy Harvesting

    KAUST Repository

    Znaidi, Mohamed Ridha

    2016-04-01

    In energy harvesting communications, the transmitters have to adapt transmission to the availability of energy harvested during communication. The performance of the transmission depends on the channel conditions which vary randomly due to mobility and environmental changes. During this work, we consider the problem of power allocation taking into account the energy arrivals over time and the quality of channel state information (CSI) available at the transmitter, in order to maximize the throughput. Differently from previous work, the CSI at the transmitter is not perfect and may include estimation errors. We solve this problem with respect to the energy harvesting constraints. Assuming a perfect knowledge of the CSI at the receiver, we determine the optimal power policy for different models of the energy arrival process (offline and online model). Indeed, we obtain the power allocation scheme when the transmitter has either perfect CSI or no CSI. We also investigate of utmost interest the case of fading channels with imperfect CSI. Moreover, a study of the asymptotic behavior of the communication system is proposed. Specifically, we analyze of the average throughput in a system where the average recharge rate goes asymptotically to zero and when it is very high.

  3. Testing catalysts for production performance and runaway limits

    Energy Technology Data Exchange (ETDEWEB)

    Berty, I.J.; Berty, J.M.; Brinkeroff, P.T.; Chovan, T. (Berty Reaction Engineers, Ltd., Akron, OH (US))

    1989-11-01

    The results of laboratory catalyst tests, conducted in recycle reactors under fixed conditions of feed rate and composition and otherwise at average production conditions, permit the evaluation of catalyst performance for production reactors. These tests are performed in short steady-state runs at stepwise increasing temperatures until a specified product concentration is reached. From these results, in addition to performance evaluation, the thermal stability criteria of the reaction can also be calculated. This information is needed to maximize production within the thermal runaway limit. Since the thermal runaway limit, estimated from the catalyst test, does not contain assumptions on kinetics, the experimentally evaluated runaway limit can be used as a benchmark to help discriminate between kinetic models that were developed from other data sets. The evaluation of the performance as well as the thermal runaway limit is shown on actual experimental measurements made for the production of ethylene oxide by oxidation of ethylene.

  4. Doublet III limiter performance and implications for mechanical design and material selection for future limiters

    Energy Technology Data Exchange (ETDEWEB)

    Sabado, M.M.; Marcus, F.B.; Trester, P.W.; Wesley, J.C.

    1979-10-01

    The plasma limiter system for Doublet III is described. Initially, high-Z materials, Ta-10W for the primary limiter and Mo for the backup limiters, were selected as the most attractive metallic candidates from the standpoint of thermal and structural properties. For the purpose of evaluating the effect of material Z on plasma performance, the nonmagnetic, Ni-base alloy Inconel X-750 was selected for a medium-Z limiter material. Graphite, a low-Z material, will likely be the next limiter material for evaluation. Design and material selection criteria for the different Z ranges are presented. The performance of the high-Z limiters in Doublet III is reviewed for an operation period that included approximately 5000 plasma shots. Changes in surface appearance and metallurgical changes are characterized. Discussion is presented on how and to what extent the high-Z elements affected the performance of the plasma based on theory and measurements in Doublet III. The fabrication processes for the Inconel X-750 limiters are summarized, and, last, observations on early performance of the Inconel limiters are described. (MOW)

  5. Modulation of allostery of pyruvate kinase by shifting of an ensemble of microstates

    Institute of Scientific and Technical Information of China (English)

    J.Ching Lee

    2008-01-01

    Since the introduction of the concepts of allostery about four decades ago,much advancement has been made in elucidating the structure-function correlation in allostery.However,there are still a number of issues that remain unresolved.In this review we used mammalian pyruvate kinase (PK) as a model system to understand the role of protein dynamics in modulating cooperativity.PK has a triosephosphate isomerase (TIM) (α/β)8 barrel structural motif.PK is an ideal system to address basic questions regarding regulatory mechanismsabout this common(α/β)8 structural motif.The simplest model accounting for all of the solution thermodynamic and kinetic data on iigand-enzyme interactions involves two conformational states,inactive ET and active ER.These conformational states are represented by domain movements.Further studies provide the first evidence for a differential effect of ligand binding on the dynamics of the structural elements,not major secondary structural changes.These data are consistent with our model that allosteric regulation of PK is the consequence of perturbation of the distribution of an ensemble of states in which the inactive ET and active ER represent the two extreme end states.Sequence differences and ligands can modulate the distribution of states leading to alterations of functions.The future work includes:defining the network of functionally connected residues;elucidating the chemical principles governing the sequence differences which affect functions;and probing the nature of mutations on the stability of the secondary structural elements,which in turn modulate allostery.

  6. Modulation of allostery of pyruvate kinase by shifting of an ensemble of microstates.

    Science.gov (United States)

    Lee, J Ching

    2008-07-01

    Since the introduction of the concepts of allostery about four decades ago, much advancement has been made in elucidating the structure-function correlation in allostery. However, there are still a number of issues that remain unresolved. In this review we used mammalian pyruvate kinase (PK) as a model system to understand the role of protein dynamics in modulating cooperativity. PK has a triosephosphate isomerase (TIM) (alpha/beta)(8) barrel structural motif. PK is an ideal system to address basic questions regarding regulatory mechanisms about this common (alpha/beta)(8) structural motif. The simplest model accounting for all of the solution thermodynamic and kinetic data on ligand-enzyme interactions involves two conformational states, inactive E(T) and active E(R). These conformational states are represented by domain movements. Further studies provide the first evidence for a differential effect of ligand binding on the dynamics of the structural elements, not major secondary structural changes. These data are consistent with our model that allosteric regulation of PK is the consequence of perturbation of the distribution of an ensemble of states in which the inactive E(T) and active E(R) represent the two extreme end states. Sequence differences and ligands can modulate the distribution of states leading to alterations of functions. The future work includes: defining the network of functionally connected residues; elucidating the chemical principles governing the sequence differences which affect functions; and probing the nature of mutations on the stability of the secondary structural elements, which in turn modulate allostery.

  7. Operational limitations of light water reactors relating to fuel performance

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, H S

    1976-07-01

    General aspects of fuel performance for typical Boiling and Pressurized Water Reactors are presented. Emphasis is placed on fuel failures in order to make clear important operational limitations. A discussion of fuel element designs is first given to provide the background information for the subsequent discussion of several fuel failure modes that have been identified. Fuel failure experiences through December 31, 1974, are summarized. The operational limitations that are required to mitigate the effects of fuel failures are discussed.

  8. Operational limitations of light water reactors relating to fuel performance

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, H S

    1976-07-01

    General aspects of fuel performance for typical Boiling and Pressurized Water Reactors are presented. Emphasis is placed on fuel failures in order to make clear important operational limitations. A discussion of fuel element designs is first given to provide the background information for the subsequent discussion of several fuel failure modes that have been identified. Fuel failure experiences through December 31, 1974, are summarized. The operational limitations that are required to mitigate the effects of fuel failures are discussed.

  9. Performance limits for maritime Inverse Synthetic Aperture Radar (ISAR).

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin Walter

    2013-11-01

    The performance of an Inverse Synthetic Aperture Radar (ISAR) system depends on a variety of factors, many which are interdependent in some manner. In this report we specifically examine ISAR as applied to maritime targets (e.g. ships). It is often difficult to get your arms around the problem of ascertaining achievable performance limits, and yet those limits exist and are dictated by physics. This report identifies and explores those limits, and how they depend on hardware system parameters and environmental conditions. Ultimately, this leads to a characterization of parameters that offer optimum performance for the overall ISAR system. While the information herein is not new to the literature, its collection into a single report hopes to offer some value in reducing the seek time.

  10. Dynamic allostery in the methionine repressor revealed by force distribution analysis.

    Directory of Open Access Journals (Sweden)

    Wolfram Stacklies

    2009-11-01

    Full Text Available Many fundamental cellular processes such as gene expression are tightly regulated by protein allostery. Allosteric signal propagation from the regulatory to the active site requires long-range communication, the molecular mechanism of which remains a matter of debate. A classical example for long-range allostery is the activation of the methionine repressor MetJ, a transcription factor. Binding of its co-repressor SAM increases its affinity for DNA several-fold, but has no visible conformational effect on its DNA binding interface. Our molecular dynamics simulations indicate correlated domain motions within MetJ, and quenching of these dynamics upon SAM binding entropically favors DNA binding. From monitoring conformational fluctuations alone, it is not obvious how the presence of SAM is communicated through the largely rigid core of MetJ and how SAM thereby is able to regulate MetJ dynamics. We here directly monitored the propagation of internal forces through the MetJ structure, instead of relying on conformational changes as conventionally done. Our force distribution analysis successfully revealed the molecular network for strain propagation, which connects collective domain motions through the protein core. Parts of the network are directly affected by SAM binding, giving rise to the observed quenching of fluctuations. Our results are in good agreement with experimental data. The force distribution analysis suggests itself as a valuable tool to gain insight into the molecular function of a whole class of allosteric proteins.

  11. Advanced binary geothermal power plants: Limits of performance

    Science.gov (United States)

    Bliem, C. J.; Mines, G. L.

    1991-01-01

    The Heat Cycle Research Program is investigating potential improvements to power cycles utilizing moderate temperature geothermal resources to produce electrical power. Investigations have specifically examined Rankine cycle binary power systems. Binary Rankine cycles are more efficient than the flash steam cycles at moderate resource temperature, achieving a higher net brine effectiveness. At resource conditions similar to those at the Heber binary plant, it has been shown that mixtures of saturated hydrocarbons (alkanes) or halogenated hydrocarbons operating in a supercritical Rankine cycle gave improved performance over Rankine cycles with the pure working fluids executing single or dual boiling cycles or supercritical cycles. Recently, other types of cycles have been proposed for binary geothermal service. The feasible limits on efficiency of a plant given practical limits on equipment performance is explored and the methods used in these advanced concept plants to achieve the maximum possible efficiency are discussed. (Here feasible is intended to mean reasonably achievable and not cost effective.) No direct economic analysis was made because of the sensitivity of economic results to site specific input. The limit of performance of three advanced plants were considered. The performance predictions were taken from the developers of each concept. The advanced plants considered appear to be approaching the feasible limit of performance. Ultimately, the plant designer must weigh the advantages and disadvantages of the the different cycles to find the best plant for a given service. In addition, a standard is presented of comparison of the work which has been done in the Heat Cycle Research Program and in the industrial sector by Exergy, Inc. and Polythermal Technologies.

  12. Extending the range performance of diffraction limited imagers

    Science.gov (United States)

    Vollmerhausen, Richard; Driggers, Ronald

    2017-05-01

    Even the best thermal imagers available today achieve only a fraction of the range performance that is theoretically possible with a given objective lens. Diffraction from the finite aperture of a thermal camera reduces the contrast of high spatial frequencies as well as limiting the maximum spatial frequency in the image. Reclaiming the high frequency contrast can substantially extend range over what is normally thought of as diffraction limited performance. As explained in this paper, the requirements for achieving extended range are 1) small pitch large format focal planes, 2) deep charge well capacities, and 3) intensive deconvolution processing. We will call this combination PWP for pitch, well capacity, and processing which can theoretically increase range performance by a factor of 1.7 for an increase of 70%. In this paper, we also estimate the improved range performance that results from increasing the electron well capacity of long wave infrared cameras. The three technologies needed for a significant advance in thermal imaging are all available today: these include small pixel high density focal planes, deep wells or digital read outs, and digital processors. We hope this paper excites interest in combining those technologies to provide a significant advance in thermal imager performance.

  13. Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

    Directory of Open Access Journals (Sweden)

    Nikita Chopra

    2016-03-01

    Full Text Available Bruton's tyrosine kinase (Btk is a Tec family non-receptor tyrosine kinase that plays a critical role in immune signaling and is associated with the immunological disorder X-linked agammaglobulinemia (XLA. Our previous findings showed that the Tec kinases are allosterically activated by the adjacent N-terminal linker. A single tryptophan residue in the N-terminal 17-residue linker mediates allosteric activation, and its mutation to alanine leads to the complete loss of activity. Guided by hydrogen/deuterium exchange mass spectrometry results, we have employed Molecular Dynamics simulations, Principal Component Analysis, Community Analysis and measures of node centrality to understand the details of how a single tryptophan mediates allostery in Btk. A specific tryptophan side chain rotamer promotes the functional dynamic allostery by inducing coordinated motions that spread across the kinase domain. Either a shift in the rotamer population, or a loss of the tryptophan side chain by mutation, drastically changes the coordinated motions and dynamically isolates catalytically important regions of the kinase domain. This work also identifies a new set of residues in the Btk kinase domain with high node centrality values indicating their importance in transmission of dynamics essential for kinase activation. Structurally, these node residues appear in both lobes of the kinase domain. In the N-lobe, high centrality residues wrap around the ATP binding pocket connecting previously described Catalytic-spine residues. In the C-lobe, two high centrality node residues connect the base of the R- and C-spines on the αF-helix. We suggest that the bridging residues that connect the catalytic and regulatory architecture within the kinase domain may be a crucial element in transmitting information about regulatory spine assembly to the catalytic machinery of the catalytic spine and active site.

  14. Sum of Roots Characterization for H2 Control Performance Limitations

    Science.gov (United States)

    Hara, Shinji; Kanno, Masaaki

    This paper provides new expressions of H2 control performance limits achievable by feedback for SISO continuous-time systems. The result for the regulation problem is expressed in a simple manner in terms of two sums of roots obtained from the plant and the associated polynomial spectral factorization. We show that it can connect the two existing solutions, namely the Riccati solution and the analytical expression with an integral form. The similar result for the tracking problem is also derived using the reciprocal transform. Finally parametric optimization making use of the derived expression by means of symbolic computation is demonstrated to confirm the validity of the sum of roots characterization.

  15. LEP2 Present and Future Performance and Limitations

    CERN Document Server

    Myers, S

    1998-01-01

    The LEP collider was operated during 1996 for the first time at beam energies beyond the W pair threshold. In the first period, lasting about six weeks, operation was possible at 80.5GeV per beam by powering all of the 144 superconducting cavities (sc) as well as the original 120 room temperature cavities. After the summer shutdown, when an additional 32 sc cavities were installed, operation for physics was performed at 86GeV per beam for about four weeks. The integrated luminosity at high energy, delivered to the detectors, was 25pb-1 in the two fairly short running periods. The maximum integrated luminosity over a 24 hour period exceeded 1.1pb-1. The present performance and limitations of the machine are reviewed as well as some of the crucial technical systems.

  16. Cooling performance test of the superconducting fault current limiter

    Energy Technology Data Exchange (ETDEWEB)

    Yeom, H.; Hong, Y. J.; Ko, J.; In, S.; Kim, H. B.; Park, S. J. [Korea Institute ofMachinery and Materials, Daejeon (Korea, Republic of); Kim, H.; Kim, H. R. [Korea Electric Power Corporation Research Institute, Daejeon (Korea, Republic of)

    2014-12-15

    The superconducting fault current limiter (SFCL) is an electrical power system device that detects the fault current automatically and limits the magnitude of the current below a certain safety level. The SFCL module does not have any electrical resistance below the critical temperature, which facilitates lossless power transmission in the electric power system. Once given the fault current, however, the superconducting conductor exhibits extremely high electrical resistance, and the magnitude of the current is accordingly limited to a low value. Therefore, SFCL should be maintained at a temperature below the critical temperature, which justifies the cryogenic cooling system as a mandatory component. This report is a study which reported on the cooling system for the 154 kV-class hybrid SFCL owned by Korea Electric Power Corporation (KEPCO). Using the cryocooler, the temperature of liquid nitrogen (LN2) was lowered to 71 K. The cryostat was pressurized to 5 bars to improve the dielectric strength of nitrogen and suppress nitrogen bubble foaming during operation of SFCL. The SFCL module was immersed in the liquid nitrogen of the cryostat to maintain the superconducting state. The performance test results of the key components such as cryocooler, LN2 circulation pump, cold box, and pressure builder are shown in this paper.

  17. Effects of intermediate load on performance limitations in excitation control

    Directory of Open Access Journals (Sweden)

    Pichai Aree

    2008-05-01

    Full Text Available The stability of excitation control systems is of great concern in power system operations. In this paper, the effects of intermediate load on performance limitation in excitation control are studied. The results reveal that the open-loop characteristic of synchronous machine’s flux linkage can be changed from minimum to non-minimum phase at a high level of intermediate load. This change leads to instability of synchronous machines under manual excitation control. A particular emphasis is also given to investigate the fundamental limitations in excitation control, imposed by non-minimum phases with regard to the open-loop right-half-plane (ORHP pole. The study demonstrates the difficulties of excitation control tuning to achieve the desired performance and robustness under the ORHP pole occurrence. Moreover, this paper shows the conditional stability in excitation control loop, where either an increase or decrease of the exciter gain causes a destabilization of the system’s stability. Frequency response techniques are used for these investigations.

  18. Fundamental limits of target detection performance in passive polarization imaging.

    Science.gov (United States)

    Goudail, François; Boffety, Matthieu

    2017-04-01

    We quantitatively determine the target detection performance of different passive polarization imaging architectures perturbed by signal-independent detection noise or signal-dependent Poisson shot noise. We compare the fully adaptive polarimetric imager and the best channel of a static polarimetric imager, and in each case, we compare the use of a polarizer and a polarizing beam splitter as the polarization analyzing device. For all these configurations, we derive a closed-form expression of the target/background separability and quantify the performance gain brought by polarization imaging compared to standard intensity imaging. We show in particular that all the considered polarimetric imaging configurations but one require a minimum value of the polarimetric contrast in order to outperform intensity imaging. The only configuration that always performs better than intensity imaging uses a polarizing beam splitter in the presence of background shot noise. These results are useful in evaluating the fundamental limits of the gain brought by polarization imaging and determining, in practice, which type of imaging architecture is preferable for a given application.

  19. Performance limits of plasmon-enhanced organic photovoltaics

    Energy Technology Data Exchange (ETDEWEB)

    Karatay, Durmus U.; Ginger, David S., E-mail: ginger@chem.washington.edu [Department of Physics, University of Washington, Seattle, Washington 98195 (United States); Department of Chemistry, University of Washington, Seattle, Washington 98195 (United States); Salvador, Michael [Department of Chemistry, University of Washington, Seattle, Washington 98195 (United States); Yao, Kai [Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195 (United States); Jen, Alex K.-Y. [Department of Chemistry, University of Washington, Seattle, Washington 98195 (United States); Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195 (United States)

    2014-07-21

    We use a combination of experiment and modeling to explore the promise and limitations of using plasmon-resonant metal nanoparticles to enhance the device performance of organic photovoltaics (OPVs). We focus on optical properties typical of the current generation of low-bandgap donor polymers blended with the fullerene (6,6)-phenyl C{sub 71}-butyric acid methyl ester (PC{sub 71}BM) and use the polymer poly(indacenodithiophene-co-phenanthro[9,10-b]quinoxaline) (PIDT-PhanQ) as our test case. We model the optical properties and performance of these devices both in the presence and absence of a variety of colloidal silver nanoparticles. We show that for these materials, device performance is sensitive to the relative z-position and the density of nanoparticles inside the active layer. Using conservative estimates of the internal quantum efficiency for the PIDT-PhanQ/PC{sub 71}BM blend, we calculate that optimally placed silver nanoparticles could yield an enhancement in short-circuit current density of over 31% when used with ∼ 80-nm-thick active layers, resulting in an absolute increase in power conversion efficiency of up to ∼2% for the device based on optical engineering.

  20. Performance limits of plasmon-enhanced organic photovoltaics

    Science.gov (United States)

    Karatay, Durmus U.; Salvador, Michael; Yao, Kai; Jen, Alex K.-Y.; Ginger, David S.

    2014-07-01

    We use a combination of experiment and modeling to explore the promise and limitations of using plasmon-resonant metal nanoparticles to enhance the device performance of organic photovoltaics (OPVs). We focus on optical properties typical of the current generation of low-bandgap donor polymers blended with the fullerene (6,6)-phenyl C71-butyric acid methyl ester (PC71BM) and use the polymer poly(indacenodithiophene-co-phenanthro[9,10-b]quinoxaline) (PIDT-PhanQ) as our test case. We model the optical properties and performance of these devices both in the presence and absence of a variety of colloidal silver nanoparticles. We show that for these materials, device performance is sensitive to the relative z-position and the density of nanoparticles inside the active layer. Using conservative estimates of the internal quantum efficiency for the PIDT-PhanQ/PC71BM blend, we calculate that optimally placed silver nanoparticles could yield an enhancement in short-circuit current density of over 31% when used with ˜ 80-nm-thick active layers, resulting in an absolute increase in power conversion efficiency of up to ˜2% for the device based on optical engineering.

  1. Limiting Performance of Helmets for the Prevention of Head Injury

    Directory of Open Access Journals (Sweden)

    Z.Q. Cheng

    1999-01-01

    Full Text Available This is a study of the theoretical optimal (limiting performance of helmets for the prevention of head injury. A rigid head injury model and a two-mass translational head injury model are employed. Several head injury criteria are utilized, including head acceleration, the head injury criterion (HIC, the energy imparted to the brain which is related to brain injury, and the power developed in the skull that is associated with skull fracture. A helmeted head hitting a rigid surface and a helmeted head hit by a moving object such as a ball are considered. The optimal characteristics of helmets and the impact responses of the helmeted head are investigated computationally. An experiment is conducted on an ensemble of bicycle helmets. Computational results are compared with the experimental results.

  2. Born to run. Studying the limits of human performance

    Directory of Open Access Journals (Sweden)

    Murray Andrew

    2012-07-01

    Full Text Available Abstract It is recognised that regular physical activity and a high level of fitness are powerful predictors of positive health outcomes. There is a long and rich history of significant feats of human endurance with some, for example, the death of the first marathon runner, Pheidippides, associated with negative health outcomes. Early studies on endurance running used X-ray and interview techniques to evaluate competitors and comment on performance. Since then, comparatively few studies have looked at runners competing in distances longer than a marathon. Those that have, tend to show significant musculoskeletal injuries and a remarkable level of adaptation to this endurance load. The TransEurope Footrace Project followed ultra-endurance runners aiming to complete 4,500 Km of running in 64 days across Europe. This pioneering study will assess the impact of extreme endurance on human physiology; analysing musculoskeletal and other tissue/organ injuries, and the body's potential ability to adapt to extreme physiological stress. The results will be of interest not only to endurance runners, but to anyone interested in the limits of human performance. Please see related article: http://www.biomedcentral.com/1741-7015/10/78

  3. Performance limiting effects in X-band accelerators

    Directory of Open Access Journals (Sweden)

    Faya Wang

    2011-01-01

    Full Text Available Acceleration gradient is a critical parameter for the design of future TeV-scale linear colliders. The major obstacle to higher gradient in room-temperature accelerators is rf breakdown, which is still a very mysterious phenomenon that depends on the geometry and material of the accelerator as well as the input power and operating frequency. Pulsed heating has been associated with breakdown for many years; however, there have been no experiments that clearly separate field and heating effects on the breakdown rate. Recently, such experiments have been performed at SLAC with both standing-wave and traveling-wave structures. These experiments have demonstrated that pulsed heating is limiting the gradient. Nevertheless the X-band structures breakdown studies show damage to the iris surfaces in locations of high electric field rather than of high magnetic field after thousands of breakdowns. It is not yet clear how the relative roles of electric field, magnetic field, and heating factor into the damage caused by rf breakdown. Thus, a dual-moded cavity has been designed to better study the electric field, magnetic field, and pulsed heating effects on breakdown damage.

  4. Evolution of sparsity and modularity in a model of protein allostery

    Science.gov (United States)

    Hemery, Mathieu; Rivoire, Olivier

    2015-04-01

    The sequence of a protein is not only constrained by its physical and biochemical properties under current selection, but also by features of its past evolutionary history. Understanding the extent and the form that these evolutionary constraints may take is important to interpret the information in protein sequences. To study this problem, we introduce a simple but physical model of protein evolution where selection targets allostery, the functional coupling of distal sites on protein surfaces. This model shows how the geometrical organization of couplings between amino acids within a protein structure can depend crucially on its evolutionary history. In particular, two scenarios are found to generate a spatial concentration of functional constraints: high mutation rates and fluctuating selective pressures. This second scenario offers a plausible explanation for the high tolerance of natural proteins to mutations and for the spatial organization of their least tolerant amino acids, as revealed by sequence analysis and mutagenesis experiments. It also implies a faculty to adapt to new selective pressures that is consistent with observations. The model illustrates how several independent functional modules may emerge within the same protein structure, depending on the nature of past environmental fluctuations. Our model thus relates the evolutionary history of proteins to the geometry of their functional constraints, with implications for decoding and engineering protein sequences.

  5. New open conformation of SMYD3 implicates conformational selection and allostery

    Directory of Open Access Journals (Sweden)

    Nicholas Spellmon

    2016-12-01

    Full Text Available SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly “closed” substrate-binding site and poor in vitro H3K4 methyltransferase activity have obscured further understanding of this oncogenically related protein. Here we reveal that SMYD3 can adopt an “open” conformation using molecular dynamics simulation and small-angle X-ray scattering. This ligand-binding-capable open state is related to the crystal structure-like closed state by a striking clamshell-like inter-lobe dynamics. The two states are characterized by many distinct structural and dynamical differences and the conformational transition pathway is mediated by a reversible twisting motion of the C-terminal domain (CTD. The spontaneous transition from the closed to open states suggests two possible, mutually non-exclusive models for SMYD3 functional regulation and the conformational selection mechanism and allostery may regulate the catalytic or ligand binding competence of SMYD3. This study provides an immediate clue to the puzzling role of SMYD3 in epigenetic gene regulation.

  6. Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery.

    Science.gov (United States)

    Carter, Wendy J; Myles, Timothy; Gibbs, Craig S; Leung, Lawrence L; Huntington, James A

    2004-06-18

    Thrombin is the ultimate protease of the blood clotting cascade and plays a major role in its own regulation. The ability of thrombin to exhibit both pro- and anti-coagulant properties has spawned efforts to turn thrombin into an anticoagulant for therapeutic purposes. This quest culminated in the identification of the E217K variant through scanning and saturation mutagenesis. The antithrombotic properties of E217K thrombin are derived from its inability to convert fibrinogen to a fibrin clot while maintaining its thrombomodulin-dependent ability to activate the anticoagulant protein C pathway. Here we describe the 2.5-A crystal structure of human E217K thrombin, which displays a dramatic restructuring of the geometry of the active site. Of particular interest is the repositioning of Glu-192, which hydrogen bonds to the catalytic Ser-195 and which results in the complete occlusion of the active site and the destruction of the oxyanion hole. Substrate binding pockets are further blocked by residues previously implicated in thrombin allostery. We have concluded that the E217K mutation causes the allosteric inactivation of thrombin by destabilizing the Na(+) binding site and that the structure thus may represent the Na(+)-free, catalytically inert "slow" form.

  7. Thermal performance of back-up current-limiting fuses

    Energy Technology Data Exchange (ETDEWEB)

    Torres, E.; Mazon, A.J.; Fernandez, E.; Zamora, I. [Department of Electrical Engineering, University of the Basque Country (UPV/EHU), Alameda de Urquijo, s/n, Bilbao 48013, Bizkaia (Spain); Perez, J.C. [MESA - Schneider Electric, Gatica 48110 (Spain)

    2010-12-15

    The design and development of current-limiting power fuses requires considerable time and expense on testing to verify that the maximum temperature limits under the rated current established in international standards are not exceeded. This paper presents a new methodology that reproduces the thermal behaviour of high voltage current-limiting fuses under currents up to the rated value and so, it reduces the need for testing as prototypes, more similar to the final design, can be obtained. Firstly, the methodology solves the transient heating process of the fuse to obtain the values of the power dissipated and the heat transfer coefficient, corresponding to the steady state condition. Once these values have been calculated, the temperature distribution at the surface of the complete fuse is obtained. The validity of the method proposed has been verified by comparison of the numerical values calculated with those obtained by testing real fuses. (author)

  8. Performance and Lifetime Limiting Effects in Li-ion Batteries

    DEFF Research Database (Denmark)

    Scipioni, Roberto

    Lithium-ion batteries (LIBs) find widespread use for electricity storage, from portable devices such as smart phones to electric vehicles (EV), because of their high energy density and design flexibility. However, limited lifetime is still a challenge for several LIB materials. Specifically...

  9. Limiting factors of exercise performance 1 year after lung transplantation

    NARCIS (Netherlands)

    Reinsma, G. D.; ten Hacken, N. H. T.; Grevink, R. G.; van der Bij, W.; Koer, G. H.; van Weert, E.

    2006-01-01

    Background: After lung transplantation (LTx). exercise capacity frequently remains limited, despite significantly improved pulmonary function. The aim of this study was to evaluate maximal exercise capacity and peripheral muscle force before and 1 year after LTx, and to determine whether peripheral

  10. Performance limitations for networked control systems with plant uncertainty

    Science.gov (United States)

    Chi, Ming; Guan, Zhi-Hong; Cheng, Xin-Ming; Yuan, Fu-Shun

    2016-04-01

    There has recently been significant interest in performance study for networked control systems with communication constraints. But the existing work mainly assumes that the plant has an exact model. The goal of this paper is to investigate the optimal tracking performance for networked control system in the presence of plant uncertainty. The plant under consideration is assumed to be non-minimum phase and unstable, while the two-parameter controller is employed and the integral square criterion is adopted to measure the tracking error. And we formulate the uncertainty by utilising stochastic embedding. The explicit expression of the tracking performance has been obtained. The results show that the network communication noise and the model uncertainty, as well as the unstable poles and non-minimum phase zeros, can worsen the tracking performance.

  11. Limiter

    Science.gov (United States)

    Cohen, S.A.; Hosea, J.C.; Timberlake, J.R.

    1984-10-19

    A limiter with a specially contoured front face is provided. The front face of the limiter (the plasma-side face) is flat with a central indentation. In addition, the limiter shape is cylindrically symmetric so that the limiter can be rotated for greater heat distribution. This limiter shape accommodates the various power scrape-off distances lambda p, which depend on the parallel velocity, V/sub parallel/, of the impacting particles.

  12. RESURF power semiconductor devices - Performance and operating limits

    NARCIS (Netherlands)

    Ferrara, A.

    2016-01-01

    Power transmission is the transfer of energy from a generating source to a load which uses the energy to perform useful work. Since the end of the 19th century, electrical power transmission has replaced mechanical power transmission in all long distance applications. The alternating current (AC)

  13. RESURF power semiconductor devices: performance and operating limits

    NARCIS (Netherlands)

    Ferrara, A.

    2016-01-01

    Power transmission is the transfer of energy from a generating source to a load which uses the energy to perform useful work. Since the end of the 19th century, electrical power transmission has replaced mechanical power transmission in all long distance applications. The alternating current (AC)

  14. RESURF power semiconductor devices: performance and operating limits

    NARCIS (Netherlands)

    Ferrara, Alessandro

    2016-01-01

    Power transmission is the transfer of energy from a generating source to a load which uses the energy to perform useful work. Since the end of the 19th century, electrical power transmission has replaced mechanical power transmission in all long distance applications. The alternating current (AC) ge

  15. Limited motor performance and minor neurological dysfunction at school age

    NARCIS (Netherlands)

    Peters, Lieke H. J.; Maathuis, Carel G. B.; Hadders-Algra, Mijna

    2011-01-01

    Aim: To investigate the relationship between motor performance and minor neurological dysfunction (MND) at school age. Methods: Two hundred and fifty-three children (158 boys, 95 girls; mean age 8 years and 7 months) of whom 167 children received mainstream education and 86 children special educatio

  16. A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force

    Directory of Open Access Journals (Sweden)

    Florencia Rosetti

    2015-03-01

    Full Text Available Leukocyte CD18 integrins increase their affinity for ligand by transmitting allosteric signals to and from their ligand-binding αI domain. Mechanical forces induce allosteric changes that paradoxically slow dissociation by increasing the integrin/ligand bond lifetimes, referred to as catch bonds. Mac-1 formed catch bonds with its ligands. However, a Mac-1 gene (ITGAM coding variant (rs1143679, R77H, which is located in the β-propeller domain and is significantly associated with systemic lupus erythematosus risk, exhibits a marked impairment in 2D ligand affinity and affinity maturation under mechanical force. Targeted mutations and activating antibodies reveal that the failure in Mac-1 R77H allostery is rescued by induction of cytoplasmic tail separation and full integrin extension. These findings demonstrate roles for R77, and the β-propeller in which it resides, in force-induced allostery relay and integrin bond stabilization. Defects in these processes may have pathological consequences, as the Mac-1 R77H variant is associated with increased susceptibility to lupus.

  17. Contribution of the CR domain to P-selectin lectin domain allostery by regulating the orientation of the EGF domain.

    Science.gov (United States)

    Lü, Shouqin; Chen, Shenbao; Mao, Debin; Zhang, Yan; Long, Mian

    2015-01-01

    The allostery of P-selectin has been studied extensively with a focus on the Lec and EGF domains, whereas the contribution of the CR domain remains unclear. Here, molecular dynamics simulations (MDS) combined with homology modeling were preformed to investigate the impact of the CR domain on P-selectin allostery. The results indicated that the CR domain plays a role in the allosteric dynamics of P-selectin in two ways. First, the CR1 domain tends to stabilize the low affinity of P-selectin during the equilibration processes with the transition inhibition from the S1 to S1' state by restraining the extension of the bent EGF orientation, or with the relaxation acceleration of the S2 state by promoting the bending of the extended EGF orientation. Second, the existence of CR domain increases intramolecular extension prior to complex separation, increasing the time available for the allosteric shift during forced dissociation with a prolonged bond duration. These findings further our understanding of the structure-function relationship of P-selectin with the enriched micro-structural bases of the CR domain.

  18. Application of FPGA technology to performance limitations in radiation therapy

    Science.gov (United States)

    DeMarco, John J.; Smathers, J. B.; Solberg, Tim D.; Casselman, Steve

    1996-10-01

    The field programmable gate array (FPGA) is a promising technology for increasing computation performance by providing for the design of custom chips through programmable logic blocks. This technology was used to implement and test a hardware random number generator (RNG) versus four software algorithms. The custom hardware consists of a sun SBus-based board (EVC) which has been designed around a Xilinx FPGA. A timing analysis indicates the Sun/EVC hardware generator computes 1 multiplied by 106 random numbers approximately 50 times faster than the multiplicative congruential algorithm. The hardware and software RNGs were also compare using a Monte Carlo photon transport algorithm. For this comparison the Sun/EVC generator produces a performance increase of approximately 2.0 versus the software generators. This comparison is based upon 1 multiplied by 105 photon histories.

  19. Capacitor performance limitations in high power converter applications

    DEFF Research Database (Denmark)

    El-Khatib, Walid Ziad; Holbøll, Joachim; Rasmussen, Tonny Wederberg

    2013-01-01

    High voltage low inductance capacitors are used in converters as HVDC-links, snubber circuits and sub model (MMC) capacitances. They facilitate the possibility of large peak currents under high frequent or transient voltage applications. On the other hand, using capacitors with larger equivalent...... series inductances include the risk of transient overvoltages, with a negative effect on life time and reliability of the capacitors. These allowable limits of such current and voltage peaks are decided by the ability of the converter components, including the capacitors, to withstand them over...... the expected life time. In this paper results are described from investigations on the electrical environment of these capacitors, including all the conditions they would be exposed to, thereby trying to find the tradeoffs needed to find a suitable capacitor. Different types of capacitors with the same voltage...

  20. Performance Limits of Non-Line-of-Sight Optical Communications

    Science.gov (United States)

    2015-05-01

    Universal Software Radio Peripheral (USRP) into UV communication system and employ GPS as synchronized signal to get better communication performance...ultraviolet wireless networks, the 14th ACM international conference. 30-OCT-11, Miami, Florida, USA. : , H. Ding, G. Chen, A. K. Majumdar, B. M. Sadler, Z...funded by your agreement who graduated during this period and will receive scholarships or fellowships for further studies in science, mathematics

  1. Performance limits of multilevel and multipartite quantum heat machines

    Science.gov (United States)

    Niedenzu, Wolfgang; Gelbwaser-Klimovsky, David; Kurizki, Gershon

    2015-10-01

    We present the general theory of a quantum heat machine based on an N -level system (working medium) whose N -1 excited levels are degenerate, a prerequisite for steady-state interlevel coherence. Our goal is to find out the extent to which coherence in the working medium is an asset for heat machines. The performance bounds of such a machine are common to (reciprocating) cycles that consist of consecutive strokes and continuous cycles wherein the periodically driven system is constantly coupled to cold and hot heat baths. Intriguingly, we find that the machine's performance strongly depends on the relative orientations of the transition-dipole vectors in the system. Perfectly aligned (parallel) transition dipoles allow for steady-state coherence effects, but also give rise to dark states, which hinder steady-state thermalization and thus reduce the machine's performance. Similar thermodynamic properties hold for N two-level atoms conforming to the Dicke model. We conclude that level degeneracy, but not necessarily coherence, is a thermodynamic resource, equally enhancing the heat currents and the power output of the heat machine. By contrast, the efficiency remains unaltered by this degeneracy and adheres to the Carnot bound.

  2. Are There Ethical Limitations for Improving Physical Performance in Soldiers?

    Science.gov (United States)

    2009-10-01

    un emploi, en terme de capacités individuelles, physiques et/ou cognitives. Pour être efficace, cette approche nécessite cependant que le recrutement ...agissant sur des processus de régulation centrale. Le maintien de la stabilité émotionnelle par la prise d’alcool, de -bloquants ou d’autres...et médecins. 2.1 Notions générales Pour ces différentes professions impliquées dans un processus général d’amélioration des performances, les

  3. Limitations imposed by wearing armour on Medieval soldiers' locomotor performance.

    Science.gov (United States)

    Askew, Graham N; Formenti, Federico; Minetti, Alberto E

    2012-02-22

    In Medieval Europe, soldiers wore steel plate armour for protection during warfare. Armour design reflected a trade-off between protection and mobility it offered the wearer. By the fifteenth century, a typical suit of field armour weighed between 30 and 50 kg and was distributed over the entire body. How much wearing armour affected Medieval soldiers' locomotor energetics and biomechanics is unknown. We investigated the mechanics and the energetic cost of locomotion in armour, and determined the effects on physical performance. We found that the net cost of locomotion (C(met)) during armoured walking and running is much more energetically expensive than unloaded locomotion. C(met) for locomotion in armour was 2.1-2.3 times higher for walking, and 1.9 times higher for running when compared with C(met) for unloaded locomotion at the same speed. An important component of the increased energy use results from the extra force that must be generated to support the additional mass. However, the energetic cost of locomotion in armour was also much higher than equivalent trunk loading. This additional cost is mostly explained by the increased energy required to swing the limbs and impaired breathing. Our findings can predict age-associated decline in Medieval soldiers' physical performance, and have potential implications in understanding the outcomes of past European military battles.

  4. Performance limits of a single photon counting pixel system

    Energy Technology Data Exchange (ETDEWEB)

    Chmeissani, M.; Mikulec, B. E-mail: bettina.mikulec@cern.ch

    2001-03-11

    X-ray imaging using hybrid pixel detectors in single photon counting mode is a relatively recent and exciting development. The photon counting mode implies that each pixel has a threshold in energy above which a hit is recorded. Sharing of charge between adjacent pixels would therefore lead to a loss of registered hits and for medical imaging applications to a higher patient dose. This explains why the demand for high spatial resolution and consequently small pixel sizes (<100 {mu}m) motivates the Medipix2 collaboration to study the effects of charge sharing between pixels on system performance. Two different simulation codes are used to simulate the energy loss inside the detector and the charge transport towards the pixel electrodes. The largest contribution to the lateral spreading of charge comes from diffusion and can result in a considerable loss of detection efficiency in photon counting systems for small pixel sizes.

  5. Limitation of the ECRIS performance by kinetic plasma instabilities (invited)

    Energy Technology Data Exchange (ETDEWEB)

    Tarvainen, O., E-mail: olli.tarvainen@jyu.fi; Kalvas, T.; Koivisto, H.; Komppula, J.; Kronholm, R.; Laulainen, J. [Department of Physics, University of Jyväskylä, 40500 Jyväskylä (Finland); Izotov, I.; Mansfeld, D. [Institute of Applied Physics, RAS, 46 Ul’yanova St., 603950 Nizhny Novgorod (Russian Federation); Skalyga, V. [Institute of Applied Physics, RAS, 46 Ul’yanova St., 603950 Nizhny Novgorod (Russian Federation); Lobachevsky State University of Nizhny Novgorod (UNN), 23 Gagarina St., 603950 Nizhny Novgorod (Russian Federation); Toivanen, V. [European Organization for Nuclear Research (CERN), 1211 Geneva 23 (Switzerland); Machicoane, G. [National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824 (United States)

    2016-02-15

    Electron cyclotron resonance ion source (ECRIS) plasmas are prone to kinetic instabilities due to anisotropic electron velocity distribution. The instabilities are associated with strong microwave emission and periodic bursts of energetic electrons escaping the magnetic confinement. The instabilities explain the periodic ms-scale oscillation of the extracted beam current observed with several high performance ECRISs and restrict the parameter space available for the optimization of extracted beam currents of highly charged ions. Experiments with the JYFL 14 GHz ECRIS have demonstrated that due to the instabilities the optimum B{sub min}-field is less than 0.8B{sub ECR}, which is the value suggested by the semiempirical scaling laws guiding the design of ECRISs.

  6. Performance limits of a single photon counting pixel system

    Science.gov (United States)

    Chmeissani, M.; Mikulec, B.

    2001-03-01

    X-ray imaging using hybrid pixel detectors in single photon counting mode is a relatively recent and exciting development. The photon counting mode implies that each pixel has a threshold in energy above which a hit is recorded. Sharing of charge between adjacent pixels would therefore lead to a loss of registered hits and for medical imaging applications to a higher patient dose. This explains why the demand for high spatial resolution and consequently small pixel sizes (<100 μm) motivates the Medipix2 collaboration to study the effects of charge sharing between pixels on system performance. Two different simulation codes are used to simulate the energy loss inside the detector and the charge transport towards the pixel electrodes. The largest contribution to the lateral spreading of charge comes from diffusion and can result in a considerable loss of detection efficiency in photon counting systems for small pixel sizes. The Medipix2 collaboration consists of groups from Barcelona, Cagliari, CEA/Leti DEIN, CERN, Freiburg, Glasgow, Mitthögskolan, Napoli, NIKHEF, MRC lab Cambridge, Pisa, Prague and Sassari.

  7. Effects of limited peripheral vision on shuttle sprint performance of soccer players

    NARCIS (Netherlands)

    Lemmink, KAPM; Dijkstra, B; Visscher, C

    2005-01-01

    This study examined the effect of limited peripheral vision oil the shuttle sprint performance of soccer players. Participants were 14 male soccer players of a student soccer club (M age = 22.1 yr., SD = 1.3 yr.). They performed a repeated shuttle sprint with full and limited peripheral vision. Mean

  8. Towards integrating control and information theories from information-theoretic measures to control performance limitations

    CERN Document Server

    Fang, Song; Ishii, Hideaki

    2017-01-01

    This book investigates the performance limitation issues in networked feedback systems. The fact that networked feedback systems consist of control and communication devices and systems calls for the integration of control theory and information theory. The primary contributions of this book lie in two aspects: the newly-proposed information-theoretic measures and the newly-discovered control performance limitations. We first propose a number of information notions to facilitate the analysis. Using those notions, classes of performance limitations of networked feedback systems, as well as state estimation systems, are then investigated. In general, the book presents a unique, cohesive treatment of performance limitation issues of networked feedback systems via an information-theoretic approach. This book is believed to be the first to treat the aforementioned subjects systematically and in a unified manner, offering a unique perspective differing from existing books.

  9. Modeling the performance limits of novel microcantilever heaters for volatile organic compound detection

    Science.gov (United States)

    Jahangir, Ifat; Koley, Goutam

    2017-01-01

    We present a theoretical model estimating the performance limits of novel AlGaN/GaN heterostructure based microcantilever heater sensors to perform advanced volatile organic compound (VOC) detection and mixture analysis. Operating without any specific surface functionalization or treatment; these devices utilize the strong surface polarization of AlGaN as well as the unique device geometries, to perform selective detection of analytes based on their latent heat of evaporation and molecular dipole moment over a wide concentration range. The presented model incorporates heat transfer, Joule heating, thermal expansion and evaporative heat loss mechanisms, to predict device behaviors such as temperature profiles and sensing performance limits under various steady-state and transient test conditions. In addition, the versatility of the proposed model enables us to successfully predict the capability of the device to perform mixture analysis, and provides guidelines to further optimize the device properties to achieve a limit of detection in sub-ppm concentration.

  10. Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.

    Science.gov (United States)

    Rueegg, Corina S; Michel, Gisela; Wengenroth, Laura; von der Weid, Nicolas X; Bergstraesser, Eva; Kuehni, Claudia E

    2012-01-01

    This study investigates physical performance limitations for sports and daily activities in recently diagnosed childhood cancer survivors and siblings. The Swiss Childhood Cancer Survivor Study sent a questionnaire to all survivors (≥ 16 years) registered in the Swiss Childhood Cancer Registry, who survived >5 years and were diagnosed 1976-2003 aged sports; 2) limitations in daily activities (using SF-36 physical function score). We compared results between survivors diagnosed before and after 1990 and determined predictors for both types of limitations by multivariable logistic regression. The sample included 1038 survivors and 534 siblings. Overall, 96 survivors (9.5%) and 7 siblings (1.1%) reported a limitation in sports (Odds ratio 5.5, 95%CI 2.9-10.4, pcancer, even those diagnosed recently and treated with modern protocols, remain at high risk for physical performance limitations. Treatment and follow-up care should include tailored interventions to mitigate these late effects in high-risk patients.

  11. Home and Community Environmental Features, Activity Performance, and Community Participation among Older Adults with Functional Limitations

    Directory of Open Access Journals (Sweden)

    Hsiang-Yu Yang

    2012-01-01

    Full Text Available This paper describes relationships among home and community environmental features, activity performance in the home, and community participation potential to support aging in place. A subset of data on older adults with functional limitations (=122, sixty three (63 with mobility and 59 with other limitations, were utilized in this study from a larger project's subject pool. Results showed significant and positive correlations between environmental barriers, activity dependence and difficulty at home, and less community participation in the mobility limitation group. While kitchen and bathroom features were most limiting to home performance, bathtub or shower was the only home feature, and destination social environment was the only community feature, that explained community participation. Compared to environmental features, home performance explained much more community participation. Study results provide detailed information about environmental features as well as types of home activities that can be prioritized as interventions for aging in place.

  12. Home and Community Environmental Features, Activity Performance, and Community Participation among Older Adults with Functional Limitations.

    Science.gov (United States)

    Yang, Hsiang-Yu; Sanford, Jon A

    2012-01-01

    This paper describes relationships among home and community environmental features, activity performance in the home, and community participation potential to support aging in place. A subset of data on older adults with functional limitations (N = 122), sixty three (63) with mobility and 59 with other limitations, were utilized in this study from a larger project's subject pool. Results showed significant and positive correlations between environmental barriers, activity dependence and difficulty at home, and less community participation in the mobility limitation group. While kitchen and bathroom features were most limiting to home performance, bathtub or shower was the only home feature, and destination social environment was the only community feature, that explained community participation. Compared to environmental features, home performance explained much more community participation. Study results provide detailed information about environmental features as well as types of home activities that can be prioritized as interventions for aging in place.

  13. Universality, limits and predictability of winners' performances at the Olympic Games

    CERN Document Server

    Radicchi, Filippo

    2012-01-01

    Inspired by the legendary Games held in ancient Greece, modern Olympics represent the world's largest pageant of athletic skill and competitive spirit. Athletes' performances at the Olympic Games mirror, since more than a century, human potentialities in sports, and thus provide an optimal source of information for studying the evolution of sport achievements and predicting the limits that athletes can reach. Unfortunately, the models introduced so far for the description of athletes' performances are either sophisticated or unrealistic, and more importantly, do not provide a unified theory for sport performances. Here, we address this issue by showing that relative performance improvements of medal winners at the Olympics are normally distributed, implying that the evolution of performance values can be simply described as an exponential approach to an a priori unknown limiting performance value. This law holds for all specialties in athletics - including running, jumping and throwing - and swimming. We pres...

  14. Universality, limits and predictability of gold-medal performances at the olympic games.

    Science.gov (United States)

    Radicchi, Filippo

    2012-01-01

    Inspired by the Games held in ancient Greece, modern Olympics represent the world's largest pageant of athletic skill and competitive spirit. Performances of athletes at the Olympic Games mirror, since 1896, human potentialities in sports, and thus provide an optimal source of information for studying the evolution of sport achievements and predicting the limits that athletes can reach. Unfortunately, the models introduced so far for the description of athlete performances at the Olympics are either sophisticated or unrealistic, and more importantly, do not provide a unified theory for sport performances. Here, we address this issue by showing that relative performance improvements of medal winners at the Olympics are normally distributed, implying that the evolution of performance values can be described in good approximation as an exponential approach to an a priori unknown limiting performance value. This law holds for all specialties in athletics-including running, jumping, and throwing-and swimming. We present a self-consistent method, based on normality hypothesis testing, able to predict limiting performance values in all specialties. We further quantify the most likely years in which athletes will breach challenging performance walls in running, jumping, throwing, and swimming events, as well as the probability that new world records will be established at the next edition of the Olympic Games.

  15. Universality, limits and predictability of gold-medal performances at the olympic games.

    Directory of Open Access Journals (Sweden)

    Filippo Radicchi

    Full Text Available Inspired by the Games held in ancient Greece, modern Olympics represent the world's largest pageant of athletic skill and competitive spirit. Performances of athletes at the Olympic Games mirror, since 1896, human potentialities in sports, and thus provide an optimal source of information for studying the evolution of sport achievements and predicting the limits that athletes can reach. Unfortunately, the models introduced so far for the description of athlete performances at the Olympics are either sophisticated or unrealistic, and more importantly, do not provide a unified theory for sport performances. Here, we address this issue by showing that relative performance improvements of medal winners at the Olympics are normally distributed, implying that the evolution of performance values can be described in good approximation as an exponential approach to an a priori unknown limiting performance value. This law holds for all specialties in athletics-including running, jumping, and throwing-and swimming. We present a self-consistent method, based on normality hypothesis testing, able to predict limiting performance values in all specialties. We further quantify the most likely years in which athletes will breach challenging performance walls in running, jumping, throwing, and swimming events, as well as the probability that new world records will be established at the next edition of the Olympic Games.

  16. How to Achieve the Best SRF Performance: (Practical) Limitations and Possible Solutions

    CERN Document Server

    Antoine, Claire Z.

    2014-07-17

    This chapter presents in the first part the requirement for the surface preparation of RF Niobium cavities and its justification in term s of physical origin of limitation (e.g. cleanliness and field emission, influence of the surface treatments, morphology and surface damage, etc.). In the second part we discuss the different models describing the ultimate limits of SRF cavities, and we present one of the possible ways to overcome Niobium monopoly toward higher performances.

  17. Home and Community Environmental Features, Activity Performance, and Community Participation among Older Adults with Functional Limitations

    OpenAIRE

    2012-01-01

    This paper describes relationships among home and community environmental features, activity performance in the home, and community participation potential to support aging in place. A subset of data on older adults with functional limitations ( = 1 2 2 ), sixty three (63) with mobility and 59 with other limitations, were utilized in this study from a larger project's subject pool. Results showed significant and positive correlations between environmental barriers, activity dependence and d...

  18. Performance limits for exo-clutter Ground Moving Target Indicator (GMTI) radar.

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin Walter

    2010-09-01

    The performance of a Ground Moving Target Indicator (GMTI) radar system depends on a variety of factors, many which are interdependent in some manner. It is often difficult to 'get your arms around' the problem of ascertaining achievable performance limits, and yet those limits exist and are dictated by physics. This report identifies and explores those limits, and how they depend on hardware system parameters and environmental conditions. Ultimately, this leads to a characterization of parameters that offer optimum performance for the overall GMTI radar system. While the information herein is not new to the literature, its collection into a single report hopes to offer some value in reducing the 'seek time'.

  19. Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.

    Directory of Open Access Journals (Sweden)

    Corina S Rueegg

    Full Text Available PURPOSE: This study investigates physical performance limitations for sports and daily activities in recently diagnosed childhood cancer survivors and siblings. METHODS: The Swiss Childhood Cancer Survivor Study sent a questionnaire to all survivors (≥ 16 years registered in the Swiss Childhood Cancer Registry, who survived >5 years and were diagnosed 1976-2003 aged <16 years. Siblings received similar questionnaires. We assessed two types of physical performance limitations: 1 limitations in sports; 2 limitations in daily activities (using SF-36 physical function score. We compared results between survivors diagnosed before and after 1990 and determined predictors for both types of limitations by multivariable logistic regression. RESULTS: The sample included 1038 survivors and 534 siblings. Overall, 96 survivors (9.5% and 7 siblings (1.1% reported a limitation in sports (Odds ratio 5.5, 95%CI 2.9-10.4, p<0.001, mainly caused by musculoskeletal and neurological problems. Findings were even more pronounced for children diagnosed more recently (OR 4.8, CI 2.4-9.6 and 8.3, CI 3.7-18.8 for those diagnosed <1990 and ≥ 1990, respectively; p=0.025. Mean physical function score for limitations in daily activities was 49.6 (CI 48.9-50.4 in survivors and 53.1 (CI 52.5-53.7 in siblings (p<0.001. Again, differences tended to be larger in children diagnosed more recently. Survivors of bone tumors, CNS tumors and retinoblastoma and children treated with radiotherapy were most strongly affected. CONCLUSION: Survivors of childhood cancer, even those diagnosed recently and treated with modern protocols, remain at high risk for physical performance limitations. Treatment and follow-up care should include tailored interventions to mitigate these late effects in high-risk patients.

  20. Improving the Mass-Limited Performance of Routine NMR Probes using Coupled Coils

    Science.gov (United States)

    Marsden, Brian; Lim, Victor; Taber, Bob; Zens, Albert

    2016-07-01

    We report a method to convert, on demand, a general use dual-broadband probe to a high performance mass-limited probe for both high band and low band nuclei. This technology uses magnetic coupling of inductors to achieve this capability. The method offers a cost effective way of increasing the performance of routine NMR probes without having to change probes or increase the overall foot print of the spectrometer.

  1. Universality, limits and predictability of gold-medal performances at the Olympic Games

    OpenAIRE

    Filippo Radicchi

    2012-01-01

    Inspired by the Games held in ancient Greece, modern Olympics represent the world's largest pageant of athletic skill and competitive spirit. Performances of athletes at the Olympic Games mirror, since 1896, human potentialities in sports, and thus provide an optimal source of information for studying the evolution of sport achievements and predicting the limits that athletes can reach. Unfortunately, the models introduced so far for the description of athlete performances at the Olympics are...

  2. Performance limiting effects in power generation from salinity gradients by pressure retarded osmosis.

    Science.gov (United States)

    Yip, Ngai Yin; Elimelech, Menachem

    2011-12-01

    Pressure retarded osmosis has the potential to utilize the free energy of mixing when fresh river water flows into the sea for clean and renewable power generation. Here, we present a systematic investigation of the performance limiting phenomena in pressure retarded osmosis--external concentration polarization, internal concentration polarization, and reverse draw salt flux--and offer insights on the design criteria of a high performance pressure retarded osmosis power generation system. Thin-film composite polyamide membranes were chemically modified to produce a range of membrane transport properties, and the water and salt permeabilities were characterized to determine the underlying permeability-selectivity trade-off relationship. We show that power density is constrained by the trade-off between permeability and selectivity of the membrane active layer. This behavior is attributed to the opposing influence of the beneficial effect of membrane water permeability and the detrimental impact of reverse salt flux coupled with internal concentration polarization. Our analysis reveals the intricate influence of active and support layer properties on power density and demonstrates that membrane performance is maximized by tailoring the water and salt permeabilities to the structural parameters. An analytical parameter that quantifies the relative influence of each performance limiting phenomena is employed to identify the dominant effect restricting productivity. External concentration polarization is shown to be the main factor limiting performance at high power densities. Enhancement of the hydrodynamic flow conditions in the membrane feed channel reduces external concentration polarization and thus, yields improved power density. However, doing so will also incur additional operating costs due to the accompanying hydraulic pressure loss. This study demonstrates that by thoughtful selection of the membrane properties and hydrodynamic conditions, the detrimental

  3. Performance Limiting Effects in Power Generation from Salinity Gradients by Pressure Retarded Osmosis

    KAUST Repository

    Yip, Ngai Yin

    2011-12-01

    Pressure retarded osmosis has the potential to utilize the free energy of mixing when fresh river water flows into the sea for clean and renewable power generation. Here, we present a systematic investigation of the performance limiting phenomena in pressure retarded osmosis-external concentration polarization, internal concentration polarization, and reverse draw salt flux-and offer insights on the design criteria of a high performance pressure retarded osmosis power generation system. Thin-film composite polyamide membranes were chemically modified to produce a range of membrane transport properties, and the water and salt permeabilities were characterized to determine the underlying permeability-selectivity trade-off relationship. We show that power density is constrained by the trade-off between permeability and selectivity of the membrane active layer. This behavior is attributed to the opposing influence of the beneficial effect of membrane water permeability and the detrimental impact of reverse salt flux coupled with internal concentration polarization. Our analysis reveals the intricate influence of active and support layer properties on power density and demonstrates that membrane performance is maximized by tailoring the water and salt permeabilities to the structural parameters. An analytical parameter that quantifies the relative influence of each performance limiting phenomena is employed to identify the dominant effect restricting productivity. External concentration polarization is shown to be the main factor limiting performance at high power densities. Enhancement of the hydrodynamic flow conditions in the membrane feed channel reduces external concentration polarization and thus, yields improved power density. However, doing so will also incur additional operating costs due to the accompanying hydraulic pressure loss. This study demonstrates that by thoughtful selection of the membrane properties and hydrodynamic conditions, the detrimental

  4. Follow-up skeletal surveys for nonaccidental trauma: can a more limited survey be performed?

    Energy Technology Data Exchange (ETDEWEB)

    Harlan, Susan R. [University of Utah School of Medicine, Department of Radiology, Salt Lake City, UT (United States); Nixon, G.W.; Prince, Jeffrey S. [Primary Children' s Medical Center, Department of Medical Imaging, Salt Lake City, UT (United States); Campbell, Kristine A.; Hansen, Karen [University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, UT (United States)

    2009-09-15

    Studies have demonstrated the value of the follow-up skeletal survey in identifying additional fractures, clarifying indeterminate findings, and improving dating of skeletal injuries in victims of physical abuse. To determine whether a more limited follow-up survey could yield the same radiologic data as a full follow-up survey. The study cohort comprised 101 children who had follow-up surveys that met our inclusion criteria. Consensus readings of both original and follow-up surveys were performed by two pediatric radiologists. These results were compared to determine additional findings from the follow-up surveys. Limited skeletal survey protocols were evaluated to determine whether they would detect the same fractures seen with a complete osseous survey. In the 101 children 244 fractures were identified on the initial osseous survey. Follow-up surveys demonstrated new information in 38 children (37.6%). A 15-view limited follow-up survey identified all additional information seen on the complete follow-up survey. Our data demonstrate that a 15-view limited follow-up skeletal survey could be performed without missing clinically significant new fractures and still allow proper identification of confirmed fractures or normal findings. A limited survey would decrease radiation dose in children. (orig.)

  5. Seismic fragility analysis of highway bridges considering multi-dimensional performance limit state

    Science.gov (United States)

    Wang, Qi'ang; Wu, Ziyan; Liu, Shukui

    2012-03-01

    Fragility analysis for highway bridges has become increasingly important in the risk assessment of highway transportation networks exposed to seismic hazards. This study introduces a methodology to calculate fragility that considers multi-dimensional performance limit state parameters and makes a first attempt to develop fragility curves for a multispan continuous (MSC) concrete girder bridge considering two performance limit state parameters: column ductility and transverse deformation in the abutments. The main purpose of this paper is to show that the performance limit states, which are compared with the seismic response parameters in the calculation of fragility, should be properly modeled as randomly interdependent variables instead of deterministic quantities. The sensitivity of fragility curves is also investigated when the dependency between the limit states is different. The results indicate that the proposed method can be used to describe the vulnerable behavior of bridges which are sensitive to multiple response parameters and that the fragility information generated by this method will be more reliable and likely to be implemented into transportation network loss estimation.

  6. What Limits Cardiac Performance during Exercise in Normal Subjects and in Healthy Fontan Patients?

    Directory of Open Access Journals (Sweden)

    André La Gerche

    2010-01-01

    Full Text Available Exercise is an important determinant of health but is significantly reduced in the patient with a univentricular circulation. Normal exercise physiology mandates an increase in pulmonary artery pressures which places an increased work demand on the right ventricle (RV. In a biventricular circulation with pathological increases in pulmonary vascular resistance and/or reductions in RV function, exercise-induced augmentation of cardiac output is limited. Left ventricular preload reserve is dependent upon flow through the pulmonary circulation and this requires adequate RV performance. In the Fontan patient, the reasons for exercise intolerance are complex. In those patients with myocardial dysfunction or other pathologies of the circulatory components, it is likely that these abnormalities serve as a limitation to cardiac performance during exercise. However, in the healthy Fontan patient, it may be the absence of a sub-pulmonary pump which limits normal increases in pulmonary pressures, trans-pulmonary flow requirements and cardiac output. If so, performance will be exquisitely dependent on pulmonary vascular resistance. This provides a potential explanation as to why pulmonary vasodilators may improve exercise tolerance. As has recently been demonstrated, these agents may offer an important new treatment strategy which directly addresses the physiological limitations in the Fontan patient.

  7. Design of coated standing nanowire array solar cell performing beyond the planar efficiency limits

    Science.gov (United States)

    Zeng, Yang; Ye, Qinghao; Shen, Wenzhong

    2016-05-01

    The single standing nanowire (SNW) solar cells have been proven to perform beyond the planar efficiency limits in both open-circuit voltage and internal quantum efficiency due to the built-in concentration and the shifting of the absorption front. However, the expandability of these nano-scale units to a macro-scale photovoltaic device remains unsolved. The main difficulty lies in the simultaneous preservation of an effective built-in concentration in each unit cell and a broadband high absorption capability of their array. Here, we have provided a detailed theoretical guideline for realizing a macro-scale solar cell that performs furthest beyond the planar limits. The key lies in a complementary design between the light-trapping of the single SNWs and that of the photonic crystal slab formed by the array. By tuning the hybrid HE modes of the SNWs through the thickness of a coaxial dielectric coating, the optimized coated SNW array can sustain an absorption rate over 97.5% for a period as large as 425 nm, which, together with the inherited carrier extraction advantage, leads to a cell efficiency increment of 30% over the planar limit. This work has demonstrated the viability of a large-size solar cell that performs beyond the planar limits.

  8. Thermocapillary Phenomena and Performance Limitations of a Wickless Heat Pipe in Microgravity

    Science.gov (United States)

    Kundan, Akshay; Plawsky, Joel L.; Wayner, Peter C.; Chao, David F.; Sicker, Ronald J.; Motil, Brian J.; Lorik, Tibor; Chestney, Louis; Eustace, John; Zoldak, John

    2015-04-01

    A counterintuitive, thermocapillary-induced limit to heat- pipe performance was observed that is not predicted by current thermal-fluid models. Heat pipes operate under a number of physical constraints including the capillary, boiling, sonic, and entrainment limits that fundamentally affect their performance. Temperature gradients near the heated end may be high enough to generate significant Marangoni forces that oppose the return flow of liquid from the cold end. These forces are believed to exacerbate dry out conditions and force the capillary limit to be reached prematurely. Using a combination of image and thermal data from experiments conducted on the International Space Station with a transparent heat pipe, we show that in the presence of significant Marangoni forces, dry out is not the initial mechanism limiting performance, but that the physical cause is exactly the opposite behavior: flooding of the hot end with liquid. The observed effect is a consequence of the competition between capillary and Marangoni-induced forces. The temperature signature of flooding is virtually identical to dry out, making diagnosis difficult without direct visual observation of the vapor-liquid interface.

  9. Performance evaluation of multiple relays cooperative GBn-ARQ with limited retransmission

    Institute of Scientific and Technical Information of China (English)

    Suoping Li; Yongqiang Zhou; Xijuan Yang; Zufang Dou

    2015-01-01

    We investigate the performance of multiple relays coop-erative go back n automatic repeat request (MRC-GBn-ARQ) pro-tocol with limited retransmission. An N+2-state Markov transition model is constructed for analyzing arbitrary packet transmission process with limited retransmission. Then the system’s steady-state distribution is derived by using the Kolmogorov equations. Further, the mean packet transmission delay and startup delay are obtained respectively; the channel utilization is derived based on discrete-time Geom/G/1 queue model with startup. Also, we get the energy efficiency of the MRC-GBn-ARQ based on energy analytical model. Especial y, the presented models are contrary to the classical ARQ protocols of always al owing infinite retransmis-sion, and our analysis of the MRC-GBn-ARQ protocol with limited retransmission provides theoretical results for reducing the sys-tem’s delay and energy consumption. Final y, analysis is validated through some numerical simulations.

  10. Performance Limits of Nanoelectromechanical Switches (NEMS-Based Adiabatic Logic Circuits

    Directory of Open Access Journals (Sweden)

    Samer Houri

    2013-12-01

    Full Text Available This paper qualitatively explores the performance limits, i.e., energy vs. frequency, of adiabatic logic circuits based on nanoelectromechanical (NEM switches. It is shown that the contact resistance and the electro-mechanical switching behavior of the NEM switches dictate the performance of such circuits. Simplified analytical expressions are derived based on a 1-dimensional reduced order model (ROM of the switch; the results given by this simplified model are compared to classical CMOS-based, and sub-threshold CMOS-based adiabatic logic circuits. NEMS-based circuits and CMOS-based circuits show different optimum operating conditions, depending on the device parameters and circuit operating frequency.

  11. Continuous-time performance limitations for overshoot and resulted tracking measures

    CERN Document Server

    wenczel, rob

    2011-01-01

    A dual formulation for the problem of determining absolute performance limitations on overshoot, undershoot, maximum amplitude and fluctuation minimization for continuous-time feedback systems is constructed. Determining, for example, the minimum possible overshoot attainable by all possible stabilizing controllers is an optimization task that cannot be expressed as a minimum-norm problem. It is this fact, coupled with the continuous-time rather than discrete-time formulation, that makes these problems challenging. We extend previous results to include more general reference functions, and derive new results (in continuous time) on the influence of pole/zero locations on achievable time-domain performance.

  12. A New Approach for Performance Evaluation of TCP over Interference-Limited Wireless Channels

    Institute of Scientific and Technical Information of China (English)

    LUO Rui; FAN Pingzhi

    2003-01-01

    A new metric for performance evaluation of transport control protocol(TCP) over wireless channels based on the interference-limited characteristics of code division multiple address(CDMA) system is proposed. According to the new metric, the performance of TCP over CDMA correlated channel for different protocol parameters and different versions is investigated. The results show that appropriate selection of protocol parameters and packet error rate(PER) operation point can improve significantly the capacity of packet-switched CDMA-based network.

  13. The limits of low-temperature performance of Li-ion cells

    Science.gov (United States)

    Huang, C.; Sakamoto, J.; Wolfenstine, J.; Surampudi, S.

    2000-01-01

    The results of electrode and electrolyte studies reveal that the poor low-temperature (Li-ion cells is mainly caused by the carbon electrodes and not the organic electrolytes and solid electrolyte interphase, as previously suggested. It is suggested that the main causes for the poor performance in the carbon electrodes are (i) the low value and concentration depedence of the Li diffusivity and (ii) limited Li capacity.

  14. Performance limits of binary annular phase masks codesigned for depth-of-field extension

    Science.gov (United States)

    Falcón, Rafael; Goudail, François; Kulcsár, Caroline; Sauer, Hervé

    2017-06-01

    We investigate the performance limits of hybrid imaging systems including annular binary phase masks optimized for depth-of-field (DoF) extension, as a function of the number of rings and the desired DoF range. The mask parameters are optimized taking into account deconvolution of the acquired raw image in the expression of the global performance of the imaging system. We prove that masks with a limited number of rings are sufficient to obtain near-optimal performance. Moreover, the best achievable image quality decreases as the required DoF range increases, so that for a given required image quality, the DoF extension reachable with binary phase masks is bounded. Finally, these conclusions are shown to be robust against different optical system aberrations and models of scene power spectral density. These results are important in practice to decide if annular binary phase masks are the relevant solution for a given imaging problem and for mask manufacturing, since the number and thickness of the rings reachable at affordable cost by technology are generally limited.

  15. Effects of vehicle-pedestrian interaction and speed limit on traffic performance of intersections

    Science.gov (United States)

    Li, Xiang; Sun, Jian-Qiao

    2016-10-01

    The intersection model consisting of vehicle model, pedestrian model, pedestrian-vehicle interaction model and intersection rules has been presented in this paper. The well-established vehicle and pedestrian movement models in the literature are combined and applied to the intersection system with additional rules. Extensive numerical simulations with different scenarios are carried out. The effects of road speed limit, vehicle arrival rate, pedestrian regularity rate and vehicle rational rate on the intersection performance are quantitatively investigated. Three measures of the traffic performance are studied including transportation efficiency, energy economy and traffic safety. We have found that the energy economy can be achieved with the high transportation efficiency, and that the traffic safety is in conflict with the efficiency. Furthermore, we have found that the pedestrian interference makes the intersection performance worse, resulting in lower transportation efficiency, more energy consumptions and higher safety risk.

  16. Performance of the ARPA-SMR limited-area ensemble prediction system: two flood cases

    Directory of Open Access Journals (Sweden)

    A. Montani

    2001-01-01

    Full Text Available The performance of the ARPA-SMR Limited-area Ensemble Prediction System (LEPS, generated by nesting a limited-area model on selected members of the ECMWF targeted ensemble, is evaluated for two flood events that occurred during September 1992. The predictability of the events is studied for forecast times ranging from 2 to 4 days. The extent to which floods localised in time and space can be forecast at high resolution in probabilistic terms was investigated. Rainfall probability maps generated by both LEPS and ECMWF targeted ensembles are compared for different precipitation thresholds in order to assess the impact of enhanced resolution. At all considered forecast ranges, LEPS performs better, providing a more accurate description of the event with respect to the spatio-temporal location, as well as its intensity. In both flood cases, LEPS probability maps turn out to be a very valuable tool to assist forecasters to issue flood alerts at different forecast ranges. It is also shown that at the shortest forecast range, the deterministic prediction provided by the limited area model, when run in a higher-resolution configuration, provides a very accurate rainfall pattern and a good quantitative estimate of the total rainfall deployed in the flooded regions.

  17. Critical transport rates that limit the performance of microbial electrochemistry technologies.

    Science.gov (United States)

    Popat, Sudeep C; Torres, César I

    2016-09-01

    Microbial electrochemistry technologies (METs) take advantage of the connection of microorganisms with electrodes. In the classic case of a microbial anode, the maximization of current density produced is often the goal. But, current production is dependent on many transport processes occurring, which can be rate-limiting. These include the fluxes of electron donor and acceptor, the ionic flux, the acidity and alkalinity fluxes at anode and cathode respectively, the electron transport flux at the biofilm, and the reactant/product crossover flux. Associated with these fluxes are inherent concentration gradients that can affect performance. This critical review provides an analysis on how these transport processes have hindered the development of METs, and how MET designs have evolved as more knowledge of these transport limitations is gained. Finally, suggestions are provided on how to design MET systems taking into consideration critical transport processes that are intimately linked to the current produced.

  18. Optimizing the performance and structure of the D0 Collie confidence limit evaluator

    Energy Technology Data Exchange (ETDEWEB)

    Fishchler, Mark; /Fermilab

    2010-07-01

    D0 Collie is a program used to perform limit calculations based on ensembles of pseudo-experiments ('PEs'). Since the application of this program to the crucial Higgs mass limit is quite CPU intensive, it has been deemed important to carefully review this program, with an eye toward identifying and implementing potential performance improvements. At the same time, we identify any coding errors or opportunities for potential structural (or algorithm) improvement discovered in the course of gaining sufficient understanding of the workings of Collie to sensibly explore for optimizations. Based on a careful analysis of the program, a series of code changes with potential for improving performance has been identified. The implementation and evaluation of the most important parts of this series has been done, with gratifying speedup results. The bottom line: We have identified and implemented changes leading to a factor of 2.19 speedup in the example program provided, and expected to translate to a factor of roughly 4 speedup in typical realistic usage.

  19. Prospects and performance limitations for Cu-Zn-Sn-S-Se photovoltaic technology.

    Science.gov (United States)

    Mitzi, David B; Gunawan, Oki; Todorov, Teodor K; Barkhouse, D Aaron R

    2013-08-13

    While cadmium telluride and copper-indium-gallium-sulfide-selenide (CIGSSe) solar cells have either already surpassed (for CdTe) or reached (for CIGSSe) the 1 GW yr⁻¹ production level, highlighting the promise of these rapidly growing thin-film technologies, reliance on the heavy metal cadmium and scarce elements indium and tellurium has prompted concern about scalability towards the terawatt level. Despite recent advances in structurally related copper-zinc-tin-sulfide-selenide (CZTSSe) absorbers, in which indium from CIGSSe is replaced with more plentiful and lower cost zinc and tin, there is still a sizeable performance gap between the kesterite CZTSSe and the more mature CdTe and CIGSSe technologies. This review will discuss recent progress in the CZTSSe field, especially focusing on a direct comparison with analogous higher performing CIGSSe to probe the performance bottlenecks in Earth-abundant kesterite devices. Key limitations in the current generation of CZTSSe devices include a shortfall in open circuit voltage relative to the absorber band gap and secondarily a high series resistance, which contributes to a lower device fill factor. Understanding and addressing these performance issues should yield closer performance parity between CZTSSe and CdTe/CIGSSe absorbers and hopefully facilitate a successful launch of commercialization for the kesterite-based technology.

  20. Adaptive Transmitter Optimization in Multiuser Multiantenna Systems: Theoretical Limits, Effect of Delays, and Performance Enhancements

    Directory of Open Access Journals (Sweden)

    Samardzija Dragan

    2005-01-01

    Full Text Available The advances in programmable and reconfigurable radios have rendered feasible transmitter optimization schemes that can greatly improve the performance of multiple-antenna multiuser systems. Reconfigurable radio platforms are particularly suitable for implementation of transmitter optimization at the base station. We consider the downlink of a wireless system with multiple transmit antennas at the base station and a number of mobile terminals (i.e., users each with a single receive antenna. Under an average transmit power constraint, we consider the maximum achievable sum data rates in the case of (1 zero-forcing (ZF spatial prefilter, (2 modified zero-forcing (MZF spatial prefilter, and (3 triangularization spatial prefilter coupled with dirty-paper coding (DPC transmission scheme. We show that the triangularization with DPC approaches the closed-loop MIMO rates (upper bound for higher SNRs. Further, the MZF solution performs very well for lower SNRs, while for higher SNRs, the rates for the ZF solution converge to the MZF rates. An important impediment that degrades the performance of such transmitter optimization schemes is the delay in channel state information (CSI. We characterize the fundamental limits of performance in the presence of delayed CSI and then propose performance enhancements using a linear MMSE predictor of the CSI that can be used in conjunction with transmitter optimization in multiple-antenna multiuser systems.

  1. Cathode limited charge transport and performance of thin-film rechargeable lithium batteries

    Energy Technology Data Exchange (ETDEWEB)

    Bates, J.B.; Hart, F.X.; Lubben, D.; Kwak, B.S.; van Zomeren, A.

    1994-11-01

    Several types of thin-film rechargeable batteries based on lithium metal anodes and amorphous V{sub 2}O{sub 5} (aV{sub 2}O{sub 5}), LiMn{sub 2}O{sub 4}, and LiCoO{sub 2} cathodes have been investigated in this laboratory. In all cases, the current density of these cells is limited by lithium ion transport in the cathodes. This paper, discusses sources of this impedance in Li-aV{sub 2}O{sub 5} and Li-LiMn{sub 2}O{sub 4} thin-film cells and their effect on cell performance.

  2. [Optical limiting cycling performance and photostability of vanadyl phthalocyanines and naphthalocyanines].

    Science.gov (United States)

    Feng, Miao; Zhen, Xiao; Zheng, Chan; Huang, Juan; Zhan, Hong-Bing

    2008-01-01

    Optical limiting (OL) cycling performance and photostability of vanadyl phthalocyanines (VOPcs) and naphthalocyanines (VONcs) were studied. The results show that although vanadyl 2,11,20,29-tetra-tert-butyl-2,3-naphthalocyanine has the most pronounced OL effect originally, it is not a promising OL material due to its poor photostability. Meanwhile, vanadyl 2,9, 16,23-etraphenoxy-29H, 31H-phthalocyanine is considered to be a potential OL material, owing to its considerable OL effect and good photostability. A possible photochemical mechanism behind the reverse saturable absorption (RSA) and photolysis process of the studied species is proposed.

  3. Grip and limb force limits to turning performance in competition horses

    Science.gov (United States)

    Tan, Huiling; Wilson, Alan M.

    2011-01-01

    Manoeuverability is a key requirement for successful terrestrial locomotion, especially on variable terrain, and is a deciding factor in predator–prey interaction. Compared with straight-line running, bend running requires additional leg force to generate centripetal acceleration. In humans, this results in a reduction in maximum speed during bend running and a published model assuming maximum limb force as a constraint accurately predicts how much a sprinter must slow down on a bend given his maximum straight-line speed. In contrast, greyhounds do not slow down or change stride parameters during bend running, which suggests that their limbs can apply the additional force for this manoeuvre. We collected horizontal speed and angular velocity of heading of horses while they turned in different scenarios during competitive polo and horse racing. The data were used to evaluate the limits of turning performance. During high-speed turns of large radius horizontal speed was lower on the bend, as would be predicted from a model assuming a limb force limit to running speed. During small radius turns the angular velocity of heading decreased with increasing speed in a manner consistent with the coefficient of friction of the hoof–surface interaction setting the limit to centripetal force to avoid slipping. PMID:21147799

  4. Performance limitations of label-free sensors in molecular diagnosis using complex samples

    Science.gov (United States)

    Varma, Manoj

    2016-03-01

    Label-free biosensors promised a paradigm involving direct detection of biomarkers from complex samples such as serum without requiring multistep sample processing typical of labelled methods such as ELISA or immunofluorescence assays. Label-free sensors have witnessed decades of development with a veritable zoo of techniques available today exploiting a multitude of physical effects. It is appropriate now to critically assess whether label-free technologies have succeeded in delivering their promise with respect to diagnostic applications, particularly, ambitious goals such as early cancer detection using serum biomarkers, which require low limits of detection (LoD). Comparison of nearly 120 limits of detection (LoD) values reported by labelled and label-free sensing approaches over a wide range of detection techniques and target molecules in serum revealed that labeled techniques achieve 2-3 orders of magnitude better LoDs. Data from experiments where labelled and label-free assays were performed simultaneously using the same assay parameters also confirm that the LoD achieved by labelled techniques is 2 to 3 orders of magnitude better than that by label-free techniques. Furthermore, label-free techniques required significant signal amplification, for e.g. using nanoparticle conjugated secondary antibodies, to achieve LoDs comparable to labelled methods substantially deviating from the original "direct detection" paradigm. This finding has important implications on the practical limits of applying label-free detection methods for molecular diagnosis.

  5. Grip and limb force limits to turning performance in competition horses.

    Science.gov (United States)

    Tan, Huiling; Wilson, Alan M

    2011-07-22

    Manoeuverability is a key requirement for successful terrestrial locomotion, especially on variable terrain, and is a deciding factor in predator-prey interaction. Compared with straight-line running, bend running requires additional leg force to generate centripetal acceleration. In humans, this results in a reduction in maximum speed during bend running and a published model assuming maximum limb force as a constraint accurately predicts how much a sprinter must slow down on a bend given his maximum straight-line speed. In contrast, greyhounds do not slow down or change stride parameters during bend running, which suggests that their limbs can apply the additional force for this manoeuvre. We collected horizontal speed and angular velocity of heading of horses while they turned in different scenarios during competitive polo and horse racing. The data were used to evaluate the limits of turning performance. During high-speed turns of large radius horizontal speed was lower on the bend, as would be predicted from a model assuming a limb force limit to running speed. During small radius turns the angular velocity of heading decreased with increasing speed in a manner consistent with the coefficient of friction of the hoof-surface interaction setting the limit to centripetal force to avoid slipping.

  6. Performance limitations and practical considerations associated with resistive emitter array nonuniformity correction (NUC)

    Science.gov (United States)

    Moore, Douglas K.; Stanek, Clay J.; Peterson, Curt

    1997-07-01

    Resistive array technology is finding increasing application in representing synthetic infrared targets and backgrounds. Pixel-to-pixel radiance nonuniformity is the prominent noise source from resistive arrays and must be compensated or otherwise mitigated for high-fidelity testing of infrared imaging sensors. Any imaging method for measuring and correcting nonuniformity noise is subject to theoretical performance limitations due to sensor measurement noise, geometrical resolution, background offset, and optical resolution. We derive general performance bounds as functions of sensor parameters, which are equally applicable to staring and scanning nonuniformity correction (NUC) sensors. A thorough understanding of the theoretical limitations of the process allows intelligent specification of the NUC sensor, procedures, algorithms, and processing power required for any scene projection application. We describe the NUC approach developed for the US Army's Dynamic Infrared Scene Projector (DIRSP). We also exhibit the features of our software package, which calculates emitter calibration curves from automatically collected laboratory data. We show how the code deals with practical considerations such as detector fill factor, incorrect magnification, rotation between emitter array and NUC sensor, optics anisoplanity, dead pixels, data overload, and automatic detection of emitter signals. The paper concludes by showing a glimpse of procedures, algorithms, and sensor to be used in the DIRSP.

  7. Performance test of the cryogenic cooling system for the superconducting fault current limiter

    Science.gov (United States)

    Hong, Yong-Ju; In, Sehwan; Yeom, Han-Kil; Kim, Heesun; Kim, Hye-Rim

    2015-12-01

    A Superconducting Fault Current Limiter is an electric power device which limits the fault current immediately in a power grid. The SFCL must be cooled to below the critical temperature of high temperature superconductor modules. In general, they are submerged in sub-cooled liquid nitrogen for their stable thermal characteristics. To cool and maintain the target temperature and pressure of the sub-cooled liquid nitrogen, the cryogenic cooling system should be designed well with a cryocooler and coolant circulation devices. The pressure of the cryostat for the SFCL should be pressurized to suppress the generation of nitrogen bubbles in quench mode of the SFCL. In this study, we tested the performance of the cooling system for the prototype 154 kV SFCL, which consist of a Stirling cryocooler, a subcooling cryostat, a pressure builder and a main cryostat for the SFCL module, to verify the design of the cooling system and the electric performance of the SFCL. The normal operation condition of the main cryostat is 71 K and 500 kPa. This paper presents tests results of the overall cooling system.

  8. Ultrasonic oil-film thickness measurement: an angular spectrum approach to assess performance limits.

    Science.gov (United States)

    Zhang, Jie; Drinkwater, Bruce W; Dwyer-Joyce, Rob S

    2007-05-01

    The performance of ultrasonic oil-film thickness measurement in a ball bearing is quantified. A range of different viscosity oils (Shell T68, VG15, and VG5) are used to explore the lowest reflection coefficient and hence the thinnest oil-film thickness that the system can measure. The results show a minimum reflection coefficient of 0.07 for both oil VG15 and VG5 and 0.09 for oil T68 at 50 MHz. This corresponds to an oil-film thickness of 0.4 microm for T68 oil. An angular spectrum (or Fourier decomposition) approach is used to analyze the performance of this configuration. This models the interaction of component plane waves with the measurement system and quantifies the effect of the key parameters (transducer aperture, focal length, and center frequency). The simulation shows that for a focused transducer the reflection coefficient tends to a limiting value at small oil-film thickness. For the transducer used in this paper it is shown that the limiting reflection coefficient is 0.05 and the oil-film measurement errors increase as the reflection coefficient approaches this value. The implications for improved measurement systems are then discussed.

  9. Performance of Airborne Precision Spacing Under Realistic Wind Conditions and Limited Surveillance Range

    Science.gov (United States)

    Wieland, Frederick; Santos, Michel; Krueger, William; Houston, Vincent E.

    2011-01-01

    With the expected worldwide increase of air traffic during the coming decade, both the Federal Aviation Administration's (FAA's) Next Generation Air Transportation System (NextGen), as well as Eurocontrol's Single European Sky ATM Research (SESAR) program have, as part of their plans, air traffic management (ATM) solutions that can increase performance without requiring time-consuming and expensive infrastructure changes. One such solution involves the ability of both controllers and flight crews to deliver aircraft to the runway with greater accuracy than they can today. Previous research has shown that time-based spacing techniques, wherein the controller assigns a time spacing to each pair of arriving aircraft, can achieve this goal by providing greater runway delivery accuracy and producing a concomitant increase in system-wide performance. The research described herein focuses on one specific application of time-based spacing, called Airborne Precision Spacing (APS), which has evolved over the past ten years. This research furthers APS understanding by studying its performance with realistic wind conditions obtained from atmospheric sounding data and with realistic wind forecasts obtained from the Rapid Update Cycle (RUC) short-range weather forecast. In addition, this study investigates APS performance with limited surveillance range, as provided by the Automatic Dependent Surveillance-Broadcast (ADS-B) system, and with an algorithm designed to improve APS performance when ADS-B surveillance data is unavailable. The results presented herein quantify the runway threshold delivery accuracy of APS under these conditions, and also quantify resulting workload metrics such as the number of speed changes required to maintain spacing.

  10. Nanocomposites of graphene oxide and upconversion rare-earth nanocrystals with superior optical limiting performance

    KAUST Repository

    Wei, Wei

    2012-04-20

    Upconversion rare-earth nanomaterials (URENs) possess highly efficient near-infrared (NIR), e.g., 980 nm, laser absorption and unique energy upconversion capabilities. On the other hand, graphene and its derivatives, such as graphene oxide (GO), show excellent performance in optical limiting (OL); however, the wavelengths of currently used lasers for OL studies mainly focus on either 532 or 1064 nm. To design new-generation OL materials working at other optical regions, such as the NIR, a novel nanocomposites, GO-URENs, which combines the advantages of both its components, is synthesized by a one-step chemical reaction. Transmission electron microscopy, X-ray diffraction, infrared spectroscopy, and fluorescence studies prove that the α-phase URENs uniformly attach on the GO surface via covalent chemical bonding, which assures highly efficient energy transfer between URENs and GO, and also accounts for the significantly improved OL performance compared to either GO or URENs. The superior OL effect is also observed in the proof-of-concept thin-film product, suggesting immediate applications in making high-performance laser-protecting products and optoelectronic devices. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Effect of Inclination Angle on Performance Limit of a Closed-End Oscillating Heat Pipe

    Directory of Open Access Journals (Sweden)

    T. Hudakorn

    2008-01-01

    Full Text Available This study presents the effect of inclination angle on the performance limit of a Closed-End Oscillating Heat Pipe (CEOHP. The study was divided into 2 corresponding parts. The first part was visual study. The CEOHP was made of Pyrex glass tube with the inner diameter of 1.0 mm, evaporator length of 50 mm and had 10 meandering turns. The lengths of the condenser, adiabatic and evaporator sections were equal. The working fluid was R123 with filling ratio at 50% of total volume of the tube. It was found from the experiment that the performance limit at the horizontal orientation was the initial dry-out because the insufficient condensed liquid film was supplied the evaporator section. At the range of inclination angle of 5-90°, the cause of performance limit was dry-out due to the flooding phenomena at the entrance of the evaporator section. The second part was quantitative study. The CEOHPs were made of copper tubes with 0.66, 1.06 and 2.03 mm inner diameters. The evaporator lengths of CEOHPs were 50, 100 and 150 mm and the number of meandering turns was 10. For each CEOHP, the lengths of evaporator, adiabatic and condenser sections were equal. The working fluids were R123, ethanol and water at a filling ratio of 50% of total volume of the tube. The experiments were conducted at the inclination angles of 0-90° with 10° increments. With the controlled vapor temperature of 60±5°C, it was found from the quantitative results that the critical heat flux decreases as the evaporator length increases and the critical heat flux increases with an increase in the inner diameter for all inclination angles. Moreover, this study establishes the correlation to predict the ratio of the critical heat flux at the inclination angle range of 10-90° and that at vertical position. The Standard Deviation (STD is ±13.8%.

  12. Performance Limitations Analysis of Imperfect Attenuators for Adaptive Self-Interference Cancellation System

    Directory of Open Access Journals (Sweden)

    J. Liu

    2016-09-01

    Full Text Available Radio frequency (RF adaptive self-interference cancellation system (RFAICS is extensively used to suppress the self-interference of radios operating in the same platform, such as military command vehicles, airplanes and navy vessels. RFAICS is generally consisted of couplers, attenuators, delay units, amplifiers, and filters and so on. However, RFAICS usually suffers severely from the imperfect attenuators. This paper firstly explores the RFAICS operation process in theory, and then thoroughly investigates and analyzes the negative effects of non-ideal attenuators on performance of RFAICS. The closed-form expressions fully describing the influences of attenuation bias and response-time respectively on the interference cancellation ratio (ICR and system convergence time (SCT are developed with this aim. Simulations are provided for the validity of the limitation analysis and obtained expressions. Results of simulations are in agreement with theoretical analysis, which is significant for component configuration in taking RFAICS into practice.

  13. Spatial noise limited NETD performance of a HgCdTe hybrid focal plane array

    Science.gov (United States)

    Gopal, Vishnu

    1996-04-01

    This paper presents a model for theoretically estimating the residual spatial noise in a direct injection readout hybrid focal plane array (FPA) consisting of photovoltaic detectors. The procedure consists of computing the response of the pixels after taking into account the nonlinearity induced by the transfer function in the hybrid configuration and the estimated r.m.s. response nonuniformity from the known input parameters of the detector and readout arrays. A linear two point nonuniformity compensation algorithm is applied to the computed pixel responses to calculate the residual spatial noise. Signal-to-spatial noise ratio is then used to estimate the spatial noise limited NETD performance of MWIR and LWIR Hg 1- x Cd x Te hybrid FPAs.

  14. [Policies and innovation in mental healthcare: limits to decoupling from the performance of the SUS].

    Science.gov (United States)

    Ribeiro, José Mendes; Inglez-Dias, Aline

    2011-12-01

    We studied Brazilian policies on mental health with respect to normative, supply and demand and financing aspects. We concluded that the sustainability of innovations in psychiatric reform depends on enhanced financing and integration with primary care community services, on the overall performance of SUS and the reduction of autonomous and exclusive services in primary care. There is high and rising pressure in demand for services measured in DALY and the incidence of disease. The reduction observed in psychiatric beds was accompanied by the systemic reduction, though with selective reduction for psychiatric hospitalizations. CAPS services have institutional limits due to the model adopted of direct public administration and local government capacity. Secondary data available show that: (i) SUS has a virtual monopoly on general outpatient and hospital services; (ii) mental health specialists belong mostly to SUS; (iii) most mental health services are outpatient services; (iv) few CAPS have day-bed services available; and (v) there is reduced federal financing for these innovations.

  15. Performance of the MACRO limited streamer tubes for estimates of muon energy

    CERN Document Server

    Giorgini, M

    2002-01-01

    The MACRO limited streamer tubes can be operated in drift mode by using the TDCs included in the QTP system. In this way a considerable improvement in the space resolution is obtained, allowing the analysis of muon tracks in terms of multiple scattering effects and the energy estimates of muons crossing the detector. We present the results of two dedicated tests, performed with the CERN PS-T9 and SPS-X7 beams, to provide a full check of the electronics and to exploit the feasibility of the analysis. Using a neural network, we are able to estimate the muon energies up to E/sub mu / approximately = 40 GeV. The test beam data provide then an absolute energy calibration, which allows to apply the method to the MACRO data. (5 refs).

  16. Improved optical limiting performance of laser-ablation-generated metal nanoparticles due to silica-microsphere-induced local field enhancement

    OpenAIRE

    Zheren Du; Lianwei Chen; Tsung-Sheng Kao; Mengxue Wu; Minghui Hong

    2015-01-01

    For practical application, optical limiting materials must exhibit a fast response and a low threshold in order to be used for the protection of the human eye and electro-optical sensors against intense light. Many nanomaterials have been found to exhibit optical limiting properties. Laser ablation offers the possibility of fabricating nanoparticles from a wide range of target materials. For practical use of these materials, their optical limiting performance, including optical limiting thres...

  17. Performance of eddy-covariance measurements in fetch-limited applications

    Science.gov (United States)

    Nicolini, G.; Fratini, G.; Avilov, V.; Kurbatova, J. A.; Vasenev, I.; Valentini, R.

    2017-02-01

    When estimating gas fluxes by means of the eddy covariance (EC) technique, measurement representativeness is ensured by the availability of an adequate fetch. In applications over spatially limited fetches, it is possible to constrain the sensed source area by shortening the measurement height, but this comes at the cost of potentially violating some fundamental assumptions of the method or introducing significant measurement errors. In addition, reliability of footprint models when applied to measurements close to the surface is still debatable. In this manuscript, we investigate whether it is possible to use the EC method for determining the surface-atmosphere exchange over spatially limited ecosystems on horizontal scales of about 100 m. The objectives are (1) to determine the adequate positioning of the instruments in the atmospheric boundary layer, (2) to assess the quality of measurement in search of potential biases, (3) establish whether the source area is sufficiently constrained, (4) and evaluate the performances of some popular footprint models in such conditions. Most notably, we carried out an experiment to assess the footprint of two low EC systems and to evaluate the prediction of the selected footprint models against empirical data.

  18. Above- and belowground competition from longleaf pine plantations limits performance of reintroduced herbaceous species.

    Energy Technology Data Exchange (ETDEWEB)

    T.B. Harrington; C.M. Dagley; M.B. Edwards.

    2003-10-01

    Although overstory trees limit the abundance and species richness of herbaceous vegetation in longleaf pine (Pinus palustris Mill.) plantations, the responsible mechanisms are poorly understood because of confounding among limiting factors. In fall 1998, research was initiated to determine the separate effects of above- and belowground competition and needlefall from overstory pines on understory plant performance. Three 13- to 15-yr-old plantations near Aiken, SC, were thinned to 0, 25, 50, or 100% of nonthinned basal area (19.5 m2 ha-1). Combinations of trenching (to eliminate root competition) and needlefall were applied to areas within each plot, and containerized seedlings of 14 perennial herbaceous species and longleaf pine were planted within each. Overstory crown closure ranged from 0 to 81%, and soil water and available nitrogen varied consistently with pine stocking, trenching, or their combination. Cover of planted species decreased an average of 16.5 and 14.1% as a result of above- and below-ground competition, respectively. Depending on species, needlefall effects were positive, negative, or negligible. Results indicate that understory restoration will be most successful when herbaceous species are established within canopy openings (0.1-0.2 ha) managed to minimize negative effects from above- and belowground competition and needlefall.

  19. Repeated-sprint performance and vastus lateralis oxygenation: effect of limited O₂ availability.

    Science.gov (United States)

    Billaut, F; Buchheit, M

    2013-06-01

    This study examined the influence of muscle deoxygenation and reoxygenation on repeated-sprint performance via manipulation of O2 delivery. Fourteen team-sport players performed 10 10-s sprints (30-s recovery) under normoxic (NM: FI O2 0.21) and acute hypoxic (HY: FI O2 0.13) conditions in a randomized, single-blind fashion and crossover design. Mechanical work was calculated and arterial O2 saturation (Sp O2 ) was estimated via pulse oximetry for every sprint. Muscle deoxyhemoglobin concentration ([HHb]) was monitored continuously by near-infrared spectroscopy. Differences between NM and HY data were analyzed for practical significance using magnitude-based inferences. HY reduced Sp O2 (-10.7 ± 1.9%, with chances to observe a higher/similar/lower value in HY of 0/0/100%) and mechanical work (-8.2 ± 2.1%; 0/0/100%). Muscle deoxygenation increased during sprints in both environments, but was almost certainly higher in HY (12.5 ± 3.1%, 100/0/0%). Between-sprint muscle reoxygenation was likely more attenuated in HY (-11.1 ± 11.9%; 2/7/91%). The impairment in mechanical work in HY was very largely correlated with HY-induced attenuation in muscle reoxygenation (r = 0.78, 90% confidence limits: 0.49; 0.91). Repeated-sprint performance is related, in part, to muscle reoxygenation capacity during recovery periods. These results extend previous findings that muscle O2 availability is important for prolonged repeated-sprint performance, in particular when the exercise is taken in hypoxia.

  20. Dual Purpose Simulation: New Data Link Test and Performance Limit Testing of Currently Deployed Data Link

    Science.gov (United States)

    Robinson, Daryl C.

    2002-01-01

    While the results of this paper are similar to those of [I], in this paper technical difficulties present in [I] are eliminated, producing better results, enabling one to more readily see the benefits of Prioritized CSMA (PCSMA). A new analysis section also helps to generalize this research so that it is not limited to exploration of the new concept of PCSMA. Commercially available network simulation software, OPNET version 7.0, simulations are presented involving an important application of the Aeronautical Telecommunications Network (ATN), Controller Pilot Data Link Communications (CPDLC) over the Very High Frequency Data Link Mode 2 (VDL-2). Communication is modeled for essentially all incoming and outgoing nonstop air-traffic for just three United States cities: Cleveland, Cincinnati, and Detroit. The simulation involves 111 Air Traffic Control (ATC) ground stations, 32 airports distributed throughout the U.S., which are either sources or destinations for the air traffic landing or departing from the three cities, and also 1,235 equally equipped aircraft-taking off, flying realistic free-flight trajectories, and landing in a 24-hr period. Collision-less PCSMA is successfully tested and compared with the traditional CSMA typically associated with VDL-2. The performance measures include latency, throughput, and packet loss. As expected, PCSMA is much quicker and more efficient than traditional CSMA. These simulation results show the potency of PCSMA for implementing low latency, high throughput and efficient connectivity. Moreover, since PCSMA outperforms traditional CSMA, by simulating with it, we can determine the limits of performance beyond which traditional CSMA may not pass. So we have the tools to determine the traffic-loading conditions where traditional CSMA will fail, and we are testing a new and better data link that could replace it with relative ease. Work is currently being done to drastically expand the number of flights to make the simulation more

  1. Alveolar-membrane diffusing capacity limits performance in Boston marathon qualifiers.

    Directory of Open Access Journals (Sweden)

    Kaleen M Lavin

    Full Text Available PURPOSE: (1 to examine the relation between pulmonary diffusing capacity and marathon finishing time, and (2, to evaluate the accuracy of pulmonary diffusing capacity for nitric oxide (DLNO in predicting marathon finishing time relative to that of pulmonary diffusing capacity for carbon monoxide (DLCO. METHODS: 28 runners [18 males, age = 37 (SD 9 years, body mass = 70 (13 kg, height = 173 (9 cm, percent body fat = 17 (7 %] completed a test battery consisting of measurement of DLNO and DLCO at rest, and a graded exercise test to determine running economy and aerobic capacity prior to the 2011 Steamtown Marathon (Scranton, PA. One to three weeks later, all runners completed the marathon (range: 2:22:38 to 4:48:55. Linear regressions determined the relation between finishing time and a variety of anthropometric characteristics, resting lung function variables, and exercise parameters. RESULTS: In runners meeting Boston Marathon qualification standards, 74% of the variance in marathon finishing time was accounted for by differences in DLNO relative to body surface area (BSA (SEE = 11.8 min, p<0.01; however, the relation between DLNO or DLCO to finishing time was non-significant in the non-qualifiers (p = 0.14 to 0.46. Whereas both DLCO and DLNO were predictive of finishing time for all finishers, DLNO showed a stronger relation (r(2 = 0.30, SEE = 33.4 min, p<0.01 compared to DLCO when considering BSA. CONCLUSION: DLNO is a performance-limiting factor in only Boston qualifiers. This suggests that alveolar-capillary membrane conductance is a limitation to performance in faster marathoners. Additionally, DLNO/BSA predicts marathon finishing time and aerobic capacity more accurately than DLCO.

  2. Performance of Statistical Control Charts with Bilateral Limits of Probability to Monitor Processes Weibull in Maintenance

    Directory of Open Access Journals (Sweden)

    Quintana Alicia Esther

    2015-01-01

    Full Text Available Manufacturing with optimal quality standards is underpinned to the high reliability of its equipment and systems, among other essential pillars. Maintenance Engineering is responsible for planning control and continuous improvement of its critical equipment by any approach, such as Six Sigma. This is nourished by numerous statistical tools highlighting, among them, statistical process control charts. While their first applications were in production, other designs have emerged to adapt to new needs as monitoring equipment and systems in the manufacturing environment. The time between failures usually fits an exponential or Weibull model. The t chart and adjusted t chart, with probabilistic control limits, are suitable alternatives to monitor the mean time between failures. Unfortunately, it is difficult to find publications of them applied to the models Weibull, very useful in contexts such as maintenance. In addition, literature limits the study of their performance to the analysis of the standard metric average run length, thus giving a partial view. The aim of this paper is to explore the performance of the t chart and adjusted t chart using three metrics, two unconventional. To do this, it incorporates the concept of lateral variability, in their forms left and right variability. Major precisions of the behavior of these charts allow to understand the conditions under which are suitable: if the main objective of monitoring lies in detecting deterioration, the t chart with adjustment is recommended. On the other hand, when the priority is to detect improvements, the t chart without adjustment is the best choice. However, the response speed of both charts is very variable from run to run.

  3. Optimal performance of periodically driven, stochastic heat engines under limited control

    Science.gov (United States)

    Bauer, Michael; Brandner, Kay; Seifert, Udo

    2016-04-01

    We consider the performance of periodically driven stochastic heat engines in the linear response regime. Reaching the theoretical bounds for efficiency and efficiency at maximum power typically requires full control over the design and the driving of the system. We develop a framework which allows us to quantify the role that limited control over the system has on the performance. Specifically, we show that optimizing the driving entering the work extraction for a given temperature protocol leads to a universal, one-parameter dependence for both maximum efficiency and maximum power as a function of efficiency. In particular, we show that reaching Carnot efficiency (and, hence, Curzon-Ahlborn efficiency at maximum power) requires to have control over the amplitude of the full Hamiltonian of the system. Since the kinetic energy cannot be controlled by an external parameter, heat engines based on underdamped dynamics can typically not reach Carnot efficiency. We illustrate our general theory with a paradigmatic case study of a heat engine consisting of an underdamped charged particle in a modulated two-dimensional harmonic trap in the presence of a magnetic field.

  4. Optimal performance of periodically driven, stochastic heat engines under limited control.

    Science.gov (United States)

    Bauer, Michael; Brandner, Kay; Seifert, Udo

    2016-04-01

    We consider the performance of periodically driven stochastic heat engines in the linear response regime. Reaching the theoretical bounds for efficiency and efficiency at maximum power typically requires full control over the design and the driving of the system. We develop a framework which allows us to quantify the role that limited control over the system has on the performance. Specifically, we show that optimizing the driving entering the work extraction for a given temperature protocol leads to a universal, one-parameter dependence for both maximum efficiency and maximum power as a function of efficiency. In particular, we show that reaching Carnot efficiency (and, hence, Curzon-Ahlborn efficiency at maximum power) requires to have control over the amplitude of the full Hamiltonian of the system. Since the kinetic energy cannot be controlled by an external parameter, heat engines based on underdamped dynamics can typically not reach Carnot efficiency. We illustrate our general theory with a paradigmatic case study of a heat engine consisting of an underdamped charged particle in a modulated two-dimensional harmonic trap in the presence of a magnetic field.

  5. Investigating the performance limits of silicon-nanowire and carbon-nanotube FETs

    Science.gov (United States)

    Marchi, A.; Gnani, E.; Reggiani, S.; Rudan, M.; Baccarani, G.

    2006-01-01

    In this work we investigate and compare the electrostatics of fully depleted cylindrical silicon-nanowire (SiCNW) FETs, four-gate rectangular nanowire (4G RNW) FETs, tri-gate rectangular nanowire (3G RNW) FETs and gate-all-around carbon-nanotube (GAA-CNT) FETs at advanced miniaturization limits. In doing so, we rigorously solve the coupled Schrödinger-Poisson equations within the device cross-sections and fully account for quantum-mechanical effects. The investigation, carried out for the 65 and 45 nm technology nodes, leads to the unexpected conclusion that, for an assigned threshold voltage, the gate-all-around CNT-FET offers only a slightly better performance with respect to the SiCNW and the 4G RNW-FETs. This is due to the compensation of two different mechanisms, namely a higher gate effectiveness and a lower density of states. The 3G RNW yields instead an electron density within the channel which is about 25% lower than the SiCNW and 4G RNW-FETs at a given gate voltage. Such a reduced performance is due to its inherent asymmetry, which negatively affects the gate control on the channel charge.

  6. Fast and robust control of nanopositioning systems: Performance limits enabled by field programmable analog arrays

    Science.gov (United States)

    Baranwal, Mayank; Gorugantu, Ram S.; Salapaka, Srinivasa M.

    2015-08-01

    This paper aims at control design and its implementation for robust high-bandwidth precision (nanoscale) positioning systems. Even though modern model-based control theoretic designs for robust broadband high-resolution positioning have enabled orders of magnitude improvement in performance over existing model independent designs, their scope is severely limited by the inefficacies of digital implementation of the control designs. High-order control laws that result from model-based designs typically have to be approximated with reduced-order systems to facilitate digital implementation. Digital systems, even those that have very high sampling frequencies, provide low effective control bandwidth when implementing high-order systems. In this context, field programmable analog arrays (FPAAs) provide a good alternative to the use of digital-logic based processors since they enable very high implementation speeds, moreover with cheaper resources. The superior flexibility of digital systems in terms of the implementable mathematical and logical functions does not give significant edge over FPAAs when implementing linear dynamic control laws. In this paper, we pose the control design objectives for positioning systems in different configurations as optimal control problems and demonstrate significant improvements in performance when the resulting control laws are applied using FPAAs as opposed to their digital counterparts. An improvement of over 200% in positioning bandwidth is achieved over an earlier digital signal processor (DSP) based implementation for the same system and same control design, even when for the DSP-based system, the sampling frequency is about 100 times the desired positioning bandwidth.

  7. Limiting Performance Analysis of Underwater Shock Isolation of a System with Biodynamic Response Using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Z. Zong

    2000-01-01

    Full Text Available Biodynamic response of shipboard crew to underwater shock is of a major concern to navies. An underwater shock can produce very high accelerations, resulting in severe human injuries aboard a battleship. Protection of human bodies from underwater shock is implemented by installing onboard isolators. In this paper, the optimal underwater shock isolation to protect human bodies is studied. A simple shock-structure-isolator-human interaction model is first constructed. The model incorporates the effect of fluid-structure interaction, biodynamic response of human body, isolator influence. Based on this model, the optimum shock isolation is then formulated. The performance index and restriction are defined. Thirdly, GA (genetic algorithm is employed to solve the formulated optimization problem. GA is a powerful evolutionary optimization scheme suitable for large-scale and multi-variable optimization problems that are otherwise hard to be solved by conventional methods. A brief introduction to GA is given in the paper. Finally, the method is applied to an example problem and the limiting performance characteristic is obtained.

  8. Performance assessments of nuclear waste repositories--A dialogue on their value and limitations

    Science.gov (United States)

    Ewing, Rodney C.; Tierney, Martin S.; Konikowe, Leonard F.; Rechard, Rob P.

    1999-01-01

    Performance Assessment (PA) is the use of mathematical models to simulate the long-term behavior of engineered and geologic barriers in a nuclear waste repository; methods of uncertainty analysis are used to assess effects of parametric and conceptual uncertainties associated with the model system upon the uncertainty in outcomes of the simulation. PA is required by the U.S. Environmental Protection Agency as part of its certification process for geologic repositories for nuclear waste. This paper is a dialogue to explore the value and limitations of PA. Two “skeptics” acknowledge the utility of PA in organizing the scientific investigations that are necessary for confident siting and licensing of a repository; however, they maintain that the PA process, at least as it is currently implemented, is an essentially unscientific process with shortcomings that may provide results of limited use in evaluating actual effects on public health and safety. Conceptual uncertainties in a PA analysis can be so great that results can be confidently applied only over short time ranges, the antithesis of the purpose behind long-term, geologic disposal. Two “proponents” of PA agree that performance assessment is unscientific, but only in the sense that PA is an engineering analysis that uses existing scientific knowledge to support public policy decisions, rather than an investigation intended to increase fundamental knowledge of nature; PA has different goals and constraints than a typical scientific study. The “proponents” describe an ideal, sixstep process for conducting generalized PA, here called probabilistic systems analysis (PSA); they note that virtually all scientific content of a PA is introduced during the model-building steps of a PSA, they contend that a PA based on simple but scientifically acceptable mathematical models can provide useful and objective input to regulatory decision makers. The value of the results of any PA must lie between these two

  9. Physiological performance of warm-adapted marine ectotherms: Thermal limits of mitochondrial energy transduction efficiency.

    Science.gov (United States)

    Martinez, Eloy; Hendricks, Eric; Menze, Michael A; Torres, Joseph J

    2016-01-01

    Thermal regimes in aquatic systems have profound implications for the physiology of ectotherms. In particular, the effect of elevated temperatures on mitochondrial energy transduction in tropical and subtropical teleosts may have profound consequences on organismal performance and population viability. Upper and lower whole-organism critical temperatures for teleosts suggest that subtropical and tropical species are not susceptible to the warming trends associated with climate change, but sub-lethal effects on energy transduction efficiency and population dynamics remain unclear. The goal of the present study was to compare the thermal sensitivity of processes associated with mitochondrial energy transduction in liver mitochondria from the striped mojarra (Eugerres plumieri), the whitemouth croaker (Micropogonias furnieri) and the palometa (Trachinotus goodei), to those of the subtropical pinfish (Lagodon rhomboides) and the blue runner (Caranx crysos). Mitochondrial function was assayed at temperatures ranging from 10 to 40°C and results obtained for both tropical and subtropical species showed a reduction in the energy transduction efficiency of the oxidative phosphorylation (OXPHOS) system in most species studied at temperatures below whole-organism critical temperature thresholds. Our results show a loss of coupling between O2 consumption and ATP production before the onset of the critical thermal maxima, indicating that elevated temperature may severely impact the yield of ATP production per carbon unit oxidized. As warming trends are projected for tropical regions, increasing water temperatures in tropical estuaries and coral reefs could impact long-term growth and reproductive performance in tropical organisms, which are already close to their upper thermal limit.

  10. Air quality indicators from the Environmental Performance Index: potential use and limitations in South Africa

    Directory of Open Access Journals (Sweden)

    Rebecca M. Garland

    2017-06-01

    Full Text Available In responding to deteriorating air quality, many countries, including South Africa, have implemented national programmes that aim to manage and regulate ambient air quality, and the emissions of air pollutants. One aspect within these management strategies is effective communication to stakeholders, including the general public, with regard to the state and trend of ambient air quality in South Africa. Currently, information on ambient air quality is communicated through ambient mass concentration values, as well as number of exceedances of South African National Ambient Standards. However, these do not directly communicate the potential impact on human health and the ecosystem. To this end, the use of air quality indicators is seen as a potential way to achieve communication to stakeholders in a simplified, yet scientifically defensible manner. Air quality indicators and their source data from the Environmental Performance Index (EPI were interrogated to understand their potential use in South Africa. An assessment of four air quality indicators, together with their source data, showed improvements in air quality over the time period studied, though the input data do have uncertainties. The source data for the PM indicators, which came from a global dataset, underestimated the annual PM2.5 concentrations in the Highveld Priority Area and Vaal Triangle Airshed Priority Area over the time period studied (2009-2014 by ~3.7 times. This highlights a key limitation of national-scale indicators and input data, that while the data used by the EPI are a well-thought out estimate of a country’s air quality profile, they remain a generalised estimate. The assumptions and uncertainty inherent in such an ambitious global-wide attempt make the estimates inaccurate for countries without proper emissions tracking and accounting and few monitoring stations, such as South Africa. Thus, the inputs and resultant indicators should be used with caution until such

  11. Study on Recovery Performance of High Tc Superconducting Tapes for Resistive Type Superconducting Fault Current Limiter Applications

    Science.gov (United States)

    kar, Soumen; Kulkarni, Sandeep; Dixit, Manglesh; Singh, Kuwar Pal; Gupta, Alok; Balasubramanyam, P. V.; Sarangi, S. K.; Rao, V. V.

    Recent advances in reliable production of long length high temperature superconducting (HTS) tapes have resulted in commercial application of superconducting fault current limiters (SFCLs) in electrical utility networks. SFCL gives excellent technical performance when compared to conventional fault current limiters. The fast self-recovery from normal state to superconducting state immediately after the fault removal is an essential criterion for resistive type SFCL operation. In this paper, results on AC over-current testing of 1st generation (1G) Bi2223 tapes and 2nd generation (2G) YBCO coated conductors operating at 77 K are reported. From these results, the recovery time is estimated for different available HTS tapes in the market. The current limiting tests have also been performed to study the effective current limitation. Further, the recovery characteristics after the current limitation are quantitatively discussed for repetitive faults for different time intervals in the range of 100 ms to few seconds.

  12. Synthesis of N-acetamide C60 nitride and its performance of optical limiting

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    N-acetamide C60 nitride (N-acetamide-1,2-dihydro-1,2-aza-fullerene[60]) has been synthesized by the reaction of C60 and azidoacetamide and initially characterized. Its mechanism was that the objective product is formed through intermediate triazoline. The computational study shows that N-nitride structure is thermodynamically more stable by using the semi-empirical AM1 SCF-MO method. The properties of optical limiting were tested by using double frequency Nd∶YAG pulse laser system and showed that the optical limiting mechanism is reverse saturation absorption. A wavelength of 532 nm, compared with optical limiting for ns pulse, this new material has good optical limiting character for ps pulse. At wavelength of 707 nm, the capacity of optical limiting of the derivative is prior to C60.

  13. Limitations in intense exercise performance of athletes - effect of speed endurance training on ion handling and fatigue development

    DEFF Research Database (Denmark)

    Hostrup, Morten; Bangsbo, Jens

    2016-01-01

    Mechanisms underlying fatigue development and limitations for performance during intense exercise have been intensively studied during the past couple of decades. Fatigue development may involve several interacting factors and depends on type of exercise undertaken and training level...... and power output during intense exercise. Regular speed endurance training (SET), i.e. exercise performed at intensities above that corresponding to maximum oxygen consumption (VO2max ), enhances intense exercise performance. However, most of the studies that have provided mechanistic insight...

  14. Animal performance and stress: responses and tolerance limits at different levels of biological organisation.

    Science.gov (United States)

    Kassahn, Karin S; Crozier, Ross H; Pörtner, Hans O; Caley, M Julian

    2009-05-01

    Recent advances in molecular biology and the use of DNA microarrays for gene expression profiling are providing new insights into the animal stress response, particularly the effects of stress on gene regulation. However, interpretation of the complex transcriptional changes that occur during stress still poses many challenges because the relationship between changes at the transcriptional level and other levels of biological organisation is not well understood. To confront these challenges, a conceptual model linking physiological and transcriptional responses to stress would be helpful. Here, we provide the basis for one such model by synthesising data from organismal, endocrine, cellular, molecular, and genomic studies. We show using available examples from ectothermic vertebrates that reduced oxygen levels and oxidative stress are common to many stress conditions and that the responses to different types of stress, such as environmental, handling and confinement stress, often converge at the challenge of dealing with oxygen imbalance and oxidative stress. As a result, a common set of stress responses exists that is largely independent of the type of stressor applied. These common responses include the repair of DNA and protein damage, cell cycle arrest or apoptosis, changes in cellular metabolism that reflect the transition from a state of cellular growth to one of cellular repair, the release of stress hormones, changes in mitochondrial densities and properties, changes in oxygen transport capacities and changes in cardio-respiratory function. Changes at the transcriptional level recapitulate these common responses, with many stress-responsive genes functioning in cell cycle control, regulation of transcription, protein turnover, metabolism, and cellular repair. These common transcriptional responses to stress appear coordinated by only a limited number of stress-inducible and redox-sensitive transcription factors and signal transduction pathways, such as the

  15. Effects of Supply Chain Risk Management on Organization Performance: Case of Andy Forwarders Services Limited

    OpenAIRE

    Caroline Wanjiru Munyuko

    2015-01-01

    The purpose of the research was to determine the effects of Supply chain risk management on organization performance. Previous studies have focused on risk management within the general context of an organization but little attention has been focused on how supply chain risk affect organization performance in terms of its bottom line profits and overall organization objectives. Particular attention was paid to the effects of supply chain risk management variables to the performance of the org...

  16. Transmission upper limit of band-pass double-layer FSS and method of transmission performance improvement

    Institute of Scientific and Technical Information of China (English)

    Minjie Huang; Zhijun Meng

    2015-01-01

    The transmission upper limit of a double-layer frequency selective surface (FSS) with two infinitely thin metal arrays is pre-sented based on the study of the general equivalent transmission line model of a double-layer FSS. Results of theoretical analyses, numerical simulations and experiments show that this transmis-sion upper limit is independent of the array and the element, which indicates that it is impossible to achieve a transmission upper limit higher than this one under a given incident and dielectric-supporting condition by the design of the periodic array. Both the applicable condition and the possible application of the transmis-sion upper limit are discussed. The results show that the transmis-sion upper limit not only has a good reachability, but also provides a key to effectively improve the transmission performance of a double-layer FSS or more complex frequency selective structures.

  17. RETRACTED: Optical limiting performance of Ag nanoclusters synthesized by ion implantation

    Science.gov (United States)

    Wang, Y. H.; Wei, L.; Yuan, J.; Wang, R. W.; Lu, J. D.; Ji, L. L.

    2013-01-01

    Metal nanoparticles synthesized by 200 keV Ag ions into silica with dose of 2×1017 ions/cm2 has been studied. Third-order nonlinear optical properties of the nanoparticles were measured at 1064 nm excitations using the Z-scan technique. Results of the investigation of nonlinear refraction by the single beam Z-scan configuration are presented and the mechanisms responsible for the nonlinear response were discussed. Curve fitting analysis, based on MATLAB features for Ag nanoparticle optical limiting experiment, is used. The results show that Ag nanoparticles display a refractive optical limiting effect at 1064 nm.

  18. Effects of Removing the Time Limit on First and Second Language Intelligence Test Performance.

    Science.gov (United States)

    Mullane, Jennifer; McKelvie, Stuart J.

    2001-01-01

    Canadian postsecondary students (n=133) with moderate second-language competence took the Wonderlic Personnel Test with or without the standard time limit in English or French. Findings suggest that time accommodation can be applied to clients who are taking an intelligence test in their second language. (SLD)

  19. Performance of Ad Hoc Networks with Two-Hop Relay Routing and Limited Packet Lifetime

    NARCIS (Netherlands)

    Al Hanbali, Ahmad; Nain, Philippe; Altman, Eitan

    2006-01-01

    Considered is a mobile ad hoc network consisting of three types of nodes (source, destination and relay nodes) and using the two-hop relay routing protocol. Packets at relay nodes are assumed to have a limited lifetime in the network. All nodes are moving inside a bounded region according to some ra

  20. Effect of limit feeding and genomic residual feed intake on bred dairy heifer performance

    Science.gov (United States)

    The objective of this study was to evaluate growth, intake, and feed efficiency of dairy heifers with different predicted genomic residual feed intakes as lactating cows (RFI) offered diets for ad-libitum intake or limit-fed. Post-bred Holstein heifers (128, ages 14-20 months), were blocked by initi...

  1. Alkali Metal-O2 Batteries. Performance and Lifetime Limiting Effects

    DEFF Research Database (Denmark)

    Knudsen, Kristian Bastholm

    transport through Li2O2 gives further evidence that hole transport dominates charge-transfer through Li2O2. Electrochemical impedance spectroscopy was also used to conduct detailed investigations of surface capacitance, ion transport, and chargetransfer reactions in the cathode of the Li-O2 cell...... systems, the mechanisms controlling each type of battery are quite different. The discharge and charge processes of the non-aqueous Na-O2 battery were studied in this thesis. On discharge, the deposition mechanism of NaO2 was shown to be highly dependent on the current density and cell limitations could......The rechargeable Na-O2 and Li-O2 batteries are attractive battery technologies as they potentially are very cheap and as they theoretically possess about 3 and 10 times higher energy density than the current Li-ion technologies. This PhD thesis is dedicated to studying the effects that limit cell...

  2. Physical Mechanism and Fundamental Performance Limits on Graphene Non-Volatile Memory Technologies

    OpenAIRE

    Song, Emil Beom

    2012-01-01

    Non–volatile memory (NVM) constitutes a vital portion in electronics to retain information for both archiving and data processing. Limitations encountered in flash technology upon increasing density and reducing cost by scaling necessitates alternative memory structures beyond complementary–metal–oxide–semiconductor (CMOS). The single atomic two–dimensional profile and the superior physical properties of graphene allow advancements in a variety of memory metrics ...

  3. Perceptions and Performance of King Saud University Students' about Concept and Finding Limit of Functions Graphical and Symbolic

    Science.gov (United States)

    El-khateeb, Mahmoud M. A.

    2015-01-01

    The purpose of this study was to investigate the misperceptions and performance of king Saud University students' about concept and finding the limit of same partial functions given in the form of both graphical and symbolic. In the collection of the data, the researcher employed the open-ended question test consisted of four items. Firstly,…

  4. Performance limitations in the tracking and regulation problem for discrete-time systems.

    Science.gov (United States)

    Jiang, Xiao-Wei; Guan, Zhi-Hong; Yuan, Fu-Shun; Zhang, Xian-He

    2014-03-01

    In this paper, the optimal tracking and regulation performance of discrete-time, multi-input multi-output, linear time-invariant systems is investigated. The control signal is influenced by the external disturbance, and the output feedback is subjected to an additive white Gaussian noise (AWGN) corruption. The tracking error with channel input power constraint and the output regulation with control energy constraint are adopted as the measure of tracking and regulation performance respectively, which can be obtained by searching through all stabilizing two-parameter controllers. Both results demonstrate that the performance is closely related to locations and directions of the nonminimum phase zeros, unstable poles of the plant and may be badly degraded by external disturbance and AWGN.

  5. Probing the kinetic performance limits for ion chromatography. II. Gradient conditions for small ions.

    Science.gov (United States)

    Causon, Tim J; Hilder, Emily F; Shellie, Robert A; Haddad, Paul R

    2010-07-30

    A gradient kinetic plot method is used for theoretical characterisation of the performance of polymeric particulate anion exchange columns for gradient separations of small inorganic anions. The method employed requires only information obtained from a series of isocratic column performance measurements and in silico predictions of retention time and peak width under gradient conditions. Results obtained under practically constrained conditions provide parameters for the generation of high peak capacities and rapid peak production for fast analysis to be determined. Using this prediction method, a maximum theoretical peak capacity of 84 could be used to achieve separation of 26 components using a 120min gradient (R(s)>1). This approach provides a highly convenient tool for development of both mono- and multidimensional ion chromatography (IC) methodologies as it yields comprehensive understanding of the influence of gradient slope, analysis time, column length and temperature upon kinetically optimised gradient performance.

  6. Physical limitations and fundamental factors affecting performance of liquid crystal tunable lenses with concentric electrode rings.

    Science.gov (United States)

    Li, Liwei; Bryant, Doug; van Heugten, Tony; Bos, Philip J

    2013-03-20

    A comprehensive analysis of fundamental factors and their effects on the performance of liquid crystal (LC)-based lenses is given. The analysis adopts numerical LC director and electric field simulation, as well as scalar diffraction theory for calculating the lens performance considering different variable factors. A high-efficiency LC lens with concentric electrode rings is fabricated for verifying and enriching the analysis. The measurement results are in close agreement with the analysis, and a summary of key factors is given with their quantitative contributions to the efficiency.

  7. English Value-Added Measures: Examining the Limitations of School Performance Measurement

    Science.gov (United States)

    Perry, Thomas

    2016-01-01

    Value-added "Progress" measures are to be introduced for all English schools in 2016 as "headline" measures of school performance. This move comes despite research highlighting high levels of instability in value-added measures and concerns about the omission of contextual variables in the planned measure. This article studies…

  8. Discrete tyre model application for evaluation of vehicle limit handling performance

    Science.gov (United States)

    Siramdasu, Y.; Taheri, S.

    2016-11-01

    The goal of this study is twofold, first, to understand the transient and nonlinear effects of anti-lock braking systems (ABS), road undulations and driving dynamics on lateral performance of tyre and second, to develop objective handling manoeuvres and respective metrics to characterise these effects on vehicle behaviour. For studying the transient and nonlinear handling performance of the vehicle, the variations of relaxation length of tyre and tyre inertial properties play significant roles [Pacejka HB. Tire and vehicle dynamics. 3rd ed. Butterworth-Heinemann; 2012]. To accurately simulate these nonlinear effects during high-frequency vehicle dynamic manoeuvres, requires a high-frequency dynamic tyre model (? Hz). A 6 DOF dynamic tyre model integrated with enveloping model is developed and validated using fixed axle high-speed oblique cleat experimental data. Commercially available vehicle dynamics software CarSim® is used for vehicle simulation. The vehicle model was validated by comparing simulation results with experimental sinusoidal steering tests. The validated tyre model is then integrated with vehicle model and a commercial grade rule-based ABS model to perform various objective simulations. Two test scenarios of ABS braking in turn on a smooth road and accelerating in a turn on uneven and smooth roads are considered. Both test cases reiterated that while the tyre is operating in the nonlinear region of slip or slip angle, any road disturbance or high-frequency brake torque input variations can excite the inertial belt vibrations of the tyre. It is shown that these inertial vibrations can directly affect the developed performance metrics and potentially degrade the handling performance of the vehicle.

  9. Improved optical limiting performance of laser-ablation-generated metal nanoparticles due to silica-microsphere-induced local field enhancement.

    Science.gov (United States)

    Du, Zheren; Chen, Lianwei; Kao, Tsung-Sheng; Wu, Mengxue; Hong, Minghui

    2015-01-01

    For practical application, optical limiting materials must exhibit a fast response and a low threshold in order to be used for the protection of the human eye and electro-optical sensors against intense light. Many nanomaterials have been found to exhibit optical limiting properties. Laser ablation offers the possibility of fabricating nanoparticles from a wide range of target materials. For practical use of these materials, their optical limiting performance, including optical limiting threshold and the ability to efficiently attenuate high intensity light, needs to be improved. In this paper, we fabricate nanoparticles of different metals by laser ablation in liquid. We study the optical nonlinear properties of the laser-generated nanoparticle dispersion. Silica microspheres are used to enhance the optical limiting performance of the nanoparticle dispersion. The change in the optical nonlinear properties of the laser-generated nanoparticle dispersion caused by silica microspheres is studied. It is found that the incident laser beam is locally focused by the microspheres, leading to an increased optical nonlinearity of the nanoparticle dispersion.

  10. Improved optical limiting performance of laser-ablation-generated metal nanoparticles due to silica-microsphere-induced local field enhancement

    Directory of Open Access Journals (Sweden)

    Zheren Du

    2015-05-01

    Full Text Available For practical application, optical limiting materials must exhibit a fast response and a low threshold in order to be used for the protection of the human eye and electro-optical sensors against intense light. Many nanomaterials have been found to exhibit optical limiting properties. Laser ablation offers the possibility of fabricating nanoparticles from a wide range of target materials. For practical use of these materials, their optical limiting performance, including optical limiting threshold and the ability to efficiently attenuate high intensity light, needs to be improved. In this paper, we fabricate nanoparticles of different metals by laser ablation in liquid. We study the optical nonlinear properties of the laser-generated nanoparticle dispersion. Silica microspheres are used to enhance the optical limiting performance of the nanoparticle dispersion. The change in the optical nonlinear properties of the laser-generated nanoparticle dispersion caused by silica microspheres is studied. It is found that the incident laser beam is locally focused by the microspheres, leading to an increased optical nonlinearity of the nanoparticle dispersion.

  11. Microlens performance limits in sub-2mum pixel CMOS image sensors.

    Science.gov (United States)

    Huo, Yijie; Fesenmaier, Christian C; Catrysse, Peter B

    2010-03-15

    CMOS image sensors with smaller pixels are expected to enable digital imaging systems with better resolution. When pixel size scales below 2 mum, however, diffraction affects the optical performance of the pixel and its microlens, in particular. We present a first-principles electromagnetic analysis of microlens behavior during the lateral scaling of CMOS image sensor pixels. We establish for a three-metal-layer pixel that diffraction prevents the microlens from acting as a focusing element when pixels become smaller than 1.4 microm. This severely degrades performance for on and off-axis pixels in red, green and blue color channels. We predict that one-metal-layer or backside-illuminated pixels are required to extend the functionality of microlenses beyond the 1.4 microm pixel node.

  12. Performances and limits of a parallel oscillator for electrochemical quartz crystal microbalances.

    Science.gov (United States)

    Ehahoun, Hervé; Gabrielli, Claude; Keddam, Michel; Perrot, Hubert; Rousseau, Philippe

    2002-03-01

    This paper describes a driving circuit for an electrochemical quartz crystal microbalance (EQCM) adapted to a wide range of applications. The oscillator is a Miller-type parallel oscillator using an operational transconductance amplifier (OTA). A theoretical study of the oscillating circuit led to the analytical expression of the microbalance frequency as well as to an overestimation of the error on the mass measurement. The reliability of the EQCM was then experimentally verified through electrochemical copper deposition and dissolution. The limit of operation of the EQCM was also investigated, both analytically and experimentally. This work shows that parallel oscillators using few electronic components allow a very reliable EQCM to be obtained for mass measurements on metallic films, even if they are highly damped.

  13. Performance Limiting Flow Processes in High-State Loading High-Mach Number Compressors

    Science.gov (United States)

    2008-03-13

    stage matching, and thus the performance of such machines. As such, the understanding, empiricism , and guidelines which apply well to machines of lower...discrete vortex with opposite circulation to the previous one is shed. A vortex street which is " locked " to the rotor passing is thus formed downstream of...255-6802 x231 (email: [)ouglas.Rabc,(wpatb.af.rnil) Dr. John Adamczyk, retired scientist from NASA GRC, has also contributed much to the research 18. 0

  14. Thermal Performance and Operation Limit of Heat Pipe Containing Neutron Absorber

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyung Mo; Jeong, Yeong Shin; Kim, In Guk; Bang, In Choel [UNIST, Ulsan (Korea, Republic of)

    2015-05-15

    Recently, passive safety systems are under development to ensure the core cooling in accidents involving impossible depressurization such as station blackout (SBO). Hydraulic control rod drive mechanisms, passive auxiliary feedwater system (PAFS), Passive autocatalystic recombiner (PAR), and so on are types of passive safety systems to enhance the safety of nuclear power plants. Heat pipe is used in various engineering fields due to its advantages in terms of easy fabrication, high heat transfer rate, and passive heat transfer. Also, the various concepts associated with safety system and heat transfer using the heat pipe were developed in nuclear engineering field.. Thus, our group suggested the hybrid control rod which combines the functions of existing control rod and heat pipe. If there is significant temperature difference between active core and condenser, the hybrid control rod can shutdown the nuclear fission reaction and remove the decay heat from the core to ultimate heat sink. The unique characteristic of the hybrid control rod is the presence of neutron absorber inside the heat pipe. Many previous researchers studied the effect of parameters on the thermal performance of heat pipe. However, the effect of neutron absorber on the thermal performance of heat pipe has not been investigated. Thus, the annular heat pipe which contains B{sub 4}C pellet in the normal heat pipe was prepared and the thermal performance of the annular heat pipe was studied in this study. Hybrid control rod concept was developed as a passive safety system of nuclear power plant to ensure the safety of the reactor at accident condition. The hybrid control rod must contain the neutron absorber for the function as a control rod. So, the effect of neutron absorber on the thermal performance of heat pipe was experimentally investigated in this study. Temperature distributions at evaporator section of annular heat pipe were lower than normal heat pipe due to the larger volume occupied by

  15. Performance Analysis of a Power Limited Spectrum Sharing System with TAS/MRC

    KAUST Repository

    Khan, Fahd Ahmed

    2014-02-01

    Capacity of the cognitive radio network degrades due to the interference constraint from the primary network. The secondary network capacity can be enhanced in a cost effective way by means of spatial diversity, that can be achieved by adding multiple antennas on the secondary network terminals and performing antenna selection. In this paper, the performance of a multiple-input multiple-output (MIMO) secondary link with transmit antenna selection (TAS) at the transmitter and maximum ratio combining (MRC) at the receiver is analyzed. A peak transmit power constraint at the secondary transmitter is considered in addition to the interference power constraint and two scenarios are considered; 1) the MIMO cognitive system with TAS/MRC (MCS-TM) does not experience interference from the primary network (denote by MCS-TM-NI), and 2) MCS-TM does experience interference from the primary network (denote by MCS-TM-WI). The performance of both MCS-TM-NI and MCS-TM-WI is analyzed and, for a Rayleigh faded channel, closed-form expression for the outage probability is derived. In addition, closed-form expressions of the moment generating function, the symbol error rate and the ergodic capacity are obtained for the MCS-TM-NI. Asymptotic performance analysis of the MCS-TM-NI reveals that TAS/MRC in a MIMO cognitive system achieves a generalized diversity gain equal to the product of the number of transmit and receive antennas. Numerical results are also presented to corroborate the derived analytical results. © 1991-2012 IEEE.

  16. Using Mason number to predict MR damper performance from limited test data

    Science.gov (United States)

    Becnel, Andrew C.; Wereley, Norman M.

    2017-05-01

    The Mason number can be used to produce a single master curve which relates MR fluid stress versus strain rate behavior across a wide range of shear rates, temperatures, and applied magnetic fields. As applications of MR fluid energy absorbers expand to a variety of industries and operating environments, Mason number analysis offers a path to designing devices with desired performance from a minimal set of preliminary test data. Temperature strongly affects the off-state viscosity of the fluid, as the passive viscous force drops considerably at higher temperatures. Yield stress is not similarly affected, and stays relatively constant with changing temperature. In this study, a small model-scale MR fluid rotary energy absorber is used to measure the temperature correction factor of a commercially-available MR fluid from LORD Corporation. This temperature correction factor is identified from shear stress vs. shear rate data collected at four different temperatures. Measurements of the MR fluid yield stress are also obtained and related to a standard empirical formula. From these two MR fluid properties - temperature-dependent viscosity and yield stress - the temperature-corrected Mason number is shown to predict the force vs. velocity performance of a full-scale rotary MR fluid energy absorber. This analysis technique expands the design space of MR devices to high shear rates and allows for comprehensive predictions of overall performance across a wide range of operating conditions from knowledge only of the yield stress vs. applied magnetic field and a temperature-dependent viscosity correction factor.

  17. Nectar resource limitation affects butterfly flight performance and metabolism differently in intensive and extensive agricultural landscapes.

    Science.gov (United States)

    Lebeau, Julie; Wesselingh, Renate A; Van Dyck, Hans

    2016-05-11

    Flight is an essential biological ability of many insects, but is energetically costly. Environments under rapid human-induced change are characterized by habitat fragmentation and may impose constraints on the energy income budget of organisms. This may, in turn, affect locomotor performance and willingness to fly. We tested flight performance and metabolic rates in meadow brown butterflies (Maniola jurtina) of two contrasted agricultural landscapes: intensively managed, nectar-poor (IL) versus extensively managed, nectar-rich landscapes (EL). Young female adults were submitted to four nectar treatments (i.e. nectar quality and quantity) in outdoor flight cages. IL individuals had better flight capacities in a flight mill and had lower resting metabolic rates (RMR) than EL individuals, except under the severest treatment. Under this treatment, RMR increased in IL individuals, but decreased in EL individuals; flight performance was maintained by IL individuals, but dropped by a factor 2.5 in EL individuals. IL individuals had more canalized (i.e. less plastic) responses relative to the nectar treatments than EL individuals. Our results show significant intraspecific variation in the locomotor and metabolic response of a butterfly to different energy income regimes relative to the landscape of origin. Ecophysiological studies help to improve our mechanistic understanding of the eco-evolutionary impact of anthropogenic environments on rare and widespread species. © 2016 The Author(s).

  18. Compact Differential Evolution Light: High Performance Despite Limited Memory Requirement and Modest Computational Overhead

    Institute of Scientific and Technical Information of China (English)

    Giovanni Iacca; Fabio Caraffini; Ferrante Neri

    2012-01-01

    Compact algorithms are Estimation of Distribution Algorithms which mimic the behavior of population-based algorithms by means of a probabilistic representation of the population of candidate solutions.These algorithms have a similar behaviour with respect to population-based algorithms but require a much smaller memory.This feature is crucially important in some engineering applications,especially in robotics.A high performance compact algorithm is the compact Differential Evolution (cDE) algorithm.This paper proposes a novel implementation of cDE,namely compact Differential Evolution light (cDElight),to address not only the memory saving necessities but also real-time requirements.cDElight employs two novel algorithmic modifications for employing a smaller computational overhead without a performance loss,with respect to cDE.Numerical results,carried out on a broad set of test problems,show that cDElight,despite its minimal hardware requirements,does not deteriorate the performance of cDE and thus is competitive with other memory saving and population-based algorithms.An application in the field of mobile robotics highlights the usability and advantages of the proposed approach.

  19. Rule of 100: An inherent limitation or performance measure in oxidative coupling of methane?

    Institute of Scientific and Technical Information of China (English)

    Saeed Sahebdelfar; Maryam Takht Ravanchi; Mahtab Gharibi; Marzieh Hamidzadeh

    2012-01-01

    The oxidative coupling of methane over La2O3/CaO type-catalyst in a fixed-bed reactor is studied under a wide range of operating conditions (973<T< 1103 K,55< Ptotal <220 kPa,and 3.7< mcat/VSTP <50 kg·s/m3).A ten-step kinetic model incorporating all main products was used to predict the behavior of the system.Methane conversions and C2 selectivities were calculated by varying methane to oxygen ratios in the feed under different operating conditions which were also compared with the rule of 100.The results show that deviation from this rule depends on the operating conditions.Within the range studied,an increase in pressure,temperature and contact time results in smaller deviation from the rule.This rule is best approximated when the catalyst operates near its optimal performance.For negative deviations,common to the most catalysts,it is found that the optimal performance should occur at methane conversion levels lower than 50%.A plot of selectivity versus conversion for high-yield reported performance data of a large variety of catalysts shows that data points concentrated roughly in 20%-50% methane conversion region,confirning the generality and prediction of modeling.

  20. Extending the Performance of Hybrid NoCs beyond the Limitations of Network Heterogeneity

    Directory of Open Access Journals (Sweden)

    Michael Opoku Agyeman

    2017-04-01

    Full Text Available To meet the performance and scalability demands of the fast-paced technological growth towards exascale and big data processing with the performance bottleneck of conventional metal-based interconnects (wireline, alternative interconnect fabrics, such as inhomogeneous three-dimensional integrated network-on-chip (3D NoC and hybrid wired-wireless network-on-chip (WiNoC, have emanated as a cost-effective solution for emerging system-on-chip (SoC design. However, these interconnects trade off optimized performance for cost by restricting the number of area and power hungry 3D routers and wireless nodes. Moreover, the non-uniform distributed traffic in a chip multiprocessor (CMP demands an on-chip communication infrastructure that can avoid congestion under high traffic conditions while possessing minimal pipeline delay at low-load conditions. To this end, in this paper, we propose a low-latency adaptive router with a low-complexity single-cycle bypassing mechanism to alleviate the performance degradation due to the slow 2D routers in such emerging hybrid NoCs. The proposed router transmits a flit using dimension-ordered routing (DoR in the bypass datapath at low-loads. When the output port required for intra-dimension bypassing is not available, the packet is routed adaptively to avoid congestion. The router also has a simplified virtual channel allocation (VA scheme that yields a non-speculative low-latency pipeline. By combining the low-complexity bypassing technique with adaptive routing, the proposed router is able to balance the traffic in hybrid NoCs to achieve low-latency communication under various traffic loads. Simulation shows that the proposed router can reduce applications’ execution time by an average of 16.9% compared to low-latency routers, such as SWIFT. By reducing the latency between 2D routers (or wired nodes and 3D routers (or wireless nodes, the proposed router can improve the performance efficiency in terms of average

  1. Funnel plot control limits to identify poorly performing healthcare providers when there is uncertainty in the value of the benchmark.

    Science.gov (United States)

    Manktelow, Bradley N; Seaton, Sarah E; Evans, T Alun

    2014-04-17

    There is an increasing use of statistical methods, such as funnel plots, to identify poorly performing healthcare providers. Funnel plots comprise the construction of control limits around a benchmark and providers with outcomes falling outside the limits are investigated as potential outliers. The benchmark is usually estimated from observed data but uncertainty in this estimate is usually ignored when constructing control limits. In this paper, the use of funnel plots in the presence of uncertainty in the value of the benchmark is reviewed for outcomes from a Binomial distribution. Two methods to derive the control limits are shown: (i) prediction intervals; (ii) tolerance intervals. Tolerance intervals formally include the uncertainty in the value of the benchmark while prediction intervals do not. The probability properties of 95% control limits derived using each method were investigated through hypothesised scenarios. Neither prediction intervals nor tolerance intervals produce funnel plot control limits that satisfy the nominal probability characteristics when there is uncertainty in the value of the benchmark. This is not necessarily to say that funnel plots have no role to play in healthcare, but that without the development of intervals satisfying the nominal probability characteristics they must be interpreted with care.

  2. Using Mason number to predict MR damper performance from limited test data

    Directory of Open Access Journals (Sweden)

    Andrew C. Becnel

    2017-05-01

    Full Text Available The Mason number can be used to produce a single master curve which relates MR fluid stress versus strain rate behavior across a wide range of shear rates, temperatures, and applied magnetic fields. As applications of MR fluid energy absorbers expand to a variety of industries and operating environments, Mason number analysis offers a path to designing devices with desired performance from a minimal set of preliminary test data. Temperature strongly affects the off-state viscosity of the fluid, as the passive viscous force drops considerably at higher temperatures. Yield stress is not similarly affected, and stays relatively constant with changing temperature. In this study, a small model-scale MR fluid rotary energy absorber is used to measure the temperature correction factor of a commercially-available MR fluid from LORD Corporation. This temperature correction factor is identified from shear stress vs. shear rate data collected at four different temperatures. Measurements of the MR fluid yield stress are also obtained and related to a standard empirical formula. From these two MR fluid properties – temperature-dependent viscosity and yield stress – the temperature-corrected Mason number is shown to predict the force vs. velocity performance of a full-scale rotary MR fluid energy absorber. This analysis technique expands the design space of MR devices to high shear rates and allows for comprehensive predictions of overall performance across a wide range of operating conditions from knowledge only of the yield stress vs. applied magnetic field and a temperature-dependent viscosity correction factor.

  3. On the performance limiting behavior of defect clusters in commercial silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Sopori, B.L.; Chen, W.; Jones, K. [National Renewable Energy Lab., Golden, CO (United States); Gee, J. [Sandia National Labs., Albuquerque, NM (United States)

    1998-09-01

    The authors report the observation of defect clusters in high-quality, commercial silicon solar cell substrates. The nature of the defect clusters, their mechanism of formation, and precipitation of metallic impurities at the defect clusters are discussed. This defect configuration influences the device performance in a unique way--by primarily degrading the voltage-related parameters. Network modeling is used to show that, in an N/P junction device, these regions act as shunts that dissipate power generated within the cell.

  4. Winter temperatures decrease swimming performance and limit distributions of tropical damselfishes.

    Science.gov (United States)

    Johansen, Jacob L; Steffensen, John F; Jones, Geoffrey P

    2015-01-01

    Coral reefs within 10° of the equator generally experience ≤3°C seasonal variation in water temperature. Ectotherms that have evolved in these conditions are therefore expected to exhibit narrow thermal optima and be very sensitive to the greater thermal variability (>6°C) experienced at higher latitudes (≥10°N/S). The impact of increased thermal variability on the fitness and distribution of thermally sensitive reef ectotherms is currently unknown. Here, we examine site-attached planktivorous coral reef damselfishes that rely on their physiological capacity to swim and forage in the water column year round. We focus on 10 species spanning four evolutionarily distinct genera from a region of the Great Barrier Reef that experiences ≥6°C difference between seasons. Four ecologically important indicators showed reduced performance during the winter low (23°C) compared with the summer peak (29°C), with effect sizes varying among species and genera, as follows: (i) the energy available for activity (aerobic scope) was reduced by 35-45% in five species and three genera; (ii) the energetically most efficient swimming speed was reduced by 17% across all species; and (iii) the maximal critical swimming speed and (iv) the gait transition speed (the swimming mode predominantly used for foraging) were reduced by 16-42% in six species spanning all four genera. Comparisons with field surveys within and across latitudes showed that species-specific distributions were strongly correlated with these performance indicators. Species occupy habitats where they can swim faster than prevailing habitat currents year round, and >95% of individuals were observed only in habitats where the gait transition speed can be maintained at or above habitat currents. Thermal fluctuation at higher latitudes appears to reduce performance as well as the possible distribution of species and genera within and among coral reef habitats. Ultimately, thermal variability across latitudes may

  5. Ultrasonic oil-film thickness measurement: An angular spectrum approach to assess performance limits

    OpenAIRE

    Zhang, J.; Drinkwater, B.W.; Dwyer-Joyce, R.S.

    2007-01-01

    The performance of ultrasonic oil-film thickness measurement in a ball bearing is quantified. A range of different viscosity oils (Shell T68, VG15, and VG5) are used to explore the lowest reflection coefficient and hence the thinnest oil-film thickness that the system can measure. The results show a minimum reflection coefficient of 0.07 for both oil VG15 and VG5 and 0.09 for oil T68 at 50 MHz. This corresponds to an oil-film thickness of 0.4 μm for T68 oil. An angular spectrum (or Fourier d...

  6. Focal-plane optimization for detector noise limited performance in cryogenic Fourier transform spectrometer /FTS/ sensors

    Science.gov (United States)

    Mcguirk, M.; Logan, L.

    1980-01-01

    A study was performed to determine the optimum focal plane configuration including optics, filters and detector-preamplifier selection. The configuration was optimized particularly with respect to minimizing the noise level, but fabrication considerations for a cryogenic environment were also taken into account. The noise terms from source, background, detector electronics and charged particle radiation were quantitatively evaluated. It appears that noise equivalent spectral radiance less than 10 to the -11th W/sq cm per sr per kayser can be achieved between 2.5 and 20 microns.

  7. Experimental study on the performance limitation of micro heat pipes of non circular cross-sections

    Directory of Open Access Journals (Sweden)

    Mahmood Lutful Sakib

    2008-01-01

    Full Text Available An experimental study of three different cross-sections (circular, semicircular and rectangular of micro heat pipes having same hydraulic diameter (D= 3mm is carried out at three different inclination angles (0°, 45°, 90° using water as the working fluid. Evaporator section of the pipe is heated by an electric heater and the condenser section is cooled by water circulation in an annular space between the condenser section and the water jacket. Temperatures at different locations of the pipe are measured using five calibrated K type thermocouples. Heat supply is varied using a voltage regulator which is measured by a precision ammeter and a voltmeter. It is found that thermal performance tends to deteriorate as the micro heat pipe is flattened. Thus among all cross-sections of the pipes circular cross-section exhibits the best thermal performance followed by semicircular and rectangular cross-sections. Moreover maximum heat transfer capability of the pipes also decreases with decreasing of its inclination angle. A correlation is developed using all the gathered data of the present study to predict the heat transfer coefficient of micro heat pipes of different cross-sections placed at different inclination angles.

  8. Experimental determination of detection limits for performing neutron activation analysis for gold in the field

    Energy Technology Data Exchange (ETDEWEB)

    Jarzemba, M.S.; Weldy, J.; Pearcy, E.; Prikryl, J.; Pickett, D.

    1999-11-01

    Measurements are presented of gold concentration in rock/soil samples by delayed neutron activation analysis using a device and method that are potentially field portable. The device consists of a polyethylene moderator and {sup 252}Cf as the source of neutrons for activating the samples and a high-purity germanium detector to measure the 412-keV gamma-ray emissions from activated gold. This information is used to extract the gold concentration in the sample. Two types of samples were investigated: (1) pure SiO{sub 2} doped with a known amount of gold chloride and (2) US Geological Survey standards. The former types were used to evaluate optimum device performance and to calibrate the device and method. The latter types were used to show typical system performance for the intended application (field exploration for gold deposits). It was found that the device was capable of determining gold concentrations to {approximately}10 ppb with a turnaround time (the sum of irradiation, decay, and counting times) of {approximately}10 days. For samples where the gold concentration was much higher (i.e., gold ore), turnaround times are {approximately}2 days and could be shortened further by sacrificing accuracy (e.g., lessening irradiation, decay, and counting times) or by augmenting source strength.

  9. Material properties limiting the performance of CZT gamma-ray detectors

    Energy Technology Data Exchange (ETDEWEB)

    Bolotnikov,A.E.; Babalola, S.; Camarda, G. S.; Cui, Y.; Egarievwe, S. U.; Hossain, A.; Yang, G.; James, R. B.

    2009-03-16

    CdZnTe (CZT) nuclear radiation detectors are advanced sensors that utilize innovative technologies developed for wide band-gap semiconductor industry and microelectronics. They open opportunities for new types of room-temperature operating, field deployable instruments that provide accurate identification of potential radiological threats and timely awareness for both the civilian and military communities. Room-temperature radiation detectors are an emerging technology that relies on the use of high-quality CZT crystals whose availability is currently limited by material non-uniformities and the presence of extended defects. To address these issues, which are most critical to CZT sensor developments, we developed X-ray mapping and IR transmission microscopy systems to characterize both CZT crystals and devices. Since a customized system is required for such X-ray measurements, we use synchrotron radiation beams available at BNL's National Synchrotron Light Source. A highly-collimated and high-intensity X-ray beam supports measurements of areas as small as 10 x 10 {micro}m{sup 2}, and allowed us to see fluctuations in collected charge over the entire area of the detector in a reasonable time. The IR microscopy system allows for 3D visualization of Te inclusions and other extended defects. In this paper, we describe the experimental techniques used in our measurements and typical results obtained from CZT samples produced by different suppliers.

  10. Update of a thermodynamic database for radionuclides to assist solubility limits calculation for performance assessment

    Energy Technology Data Exchange (ETDEWEB)

    Duro, L.; Grive, M.; Cera, E.; Domenech, C.; Bruno, J. (Enviros Spain S.L., Barcelona (ES))

    2006-12-15

    This report presents and documents the thermodynamic database used in the assessment of the radionuclide solubility limits within the SR-Can Exercise. It is a supporting report to the solubility assessment. Thermodynamic data are reviewed for 20 radioelements from Groups A and B, lanthanides and actinides. The development of this database is partially based on the one prepared by PSI and NAGRA. Several changes, updates and checks for internal consistency and completeness to the reference NAGRA-PSI 01/01 database have been conducted when needed. These modifications are mainly related to the information from the various experimental programmes and scientific literature available until the end of 2003. Some of the discussions also refer to a previous database selection conducted by Enviros Spain on behalf of ANDRA, where the reader can find additional information. When possible, in order to optimize the robustness of the database, the description of the solubility of the different radionuclides calculated by using the reported thermodynamic database is tested in front of experimental data available in the open scientific literature. When necessary, different procedures to estimate gaps in the database have been followed, especially accounting for temperature corrections. All the methodologies followed are discussed in the main text

  11. Performance and limitations of high granularity single photon processing X-ray imaging detectors

    CERN Document Server

    Tlustos, L

    2005-01-01

    Progress in CMOS technology and in fine pitch bump bonding has made possible the development of single photon counting detectors for X-ray imaging with pixel pitches on the order of 50 µm giving a spatial resolution which is comparable to conventional CCD and flat panel detectors. This thesis studies the interaction of X-ray photons in the energy range of 5 keV to 70 keV with various sensor materials as well as the response of the Medipix2 readout system to both monochromatic and wide spectrum X-ray sources. Single photon processing offers the potential for spectroscopic imaging. However, this thesis demonstrates using simulations and measurements that the charge deposition and collection within the semiconductor sensor impose fundamental limits on the achievable energy resolution. In particular the discussion of charge during collection in the sensor and the generation of fluorescence photons in heavier sensor materials contribute to the appearance of a low energy tail on the detected spectrum of an incomin...

  12. On Varying Topology of Complex Networks and Performance Limitations of Community Detection Algorithms

    CERN Document Server

    Pasta, Muhammad Qasim; Melançon, Guy

    2016-01-01

    One of the most widely studied problem in mining and analysis of complex networks is the detection of community structures. The problem has been extensively studied by researchers due to its high utility and numerous applications in various domains. Many algorithmic solutions have been proposed for the community detection problem but the quest to find the best algorithm is still on. More often than not, researchers focus on developing fast and accurate algorithms that can be generically applied to networks from a variety of domains without taking into consideration the structural and topological variations in these networks. In this paper, we evaluate the performance of different clustering algorithms as a function of varying network topology. Along with the well known LFR model to generate benchmark networks with communities,we also propose a new model named Naive Scale Free Model to study the behavior of community detection algorithms with respect to different topological features. More specifically, we are...

  13. Probing the kinetic performance limits for ion chromatography. I. Isocratic conditions for small ions.

    Science.gov (United States)

    Causon, Tim J; Hilder, Emily F; Shellie, Robert A; Haddad, Paul R

    2010-07-30

    The first use of the kinetic plot method to characterise the performance of ion-exchange columns for separations of small inorganic anions is reported. The influence of analyte type (mono- and divalent), particle size (5 and 9microm), temperature (30 and 60 degrees C) and maximum pressure drop upon theoretical extrapolations was investigated using data collected from anion-exchange polymeric particulate columns. The quality of extrapolations was found to depend upon the choice of analyte, but could be verified by coupling a series of columns to demonstrate some practical solutions for ion chromatography separations requiring relatively high efficiency. Separations of small anions yielding 25-40,000 theoretical plates using five serially connected columns (9microm particles) were obtained and yielded deviations of columns (t(0)column operated at optimum linear velocity (t(0)>10min).

  14. Performance limits of energy harvesting communications under imperfect channel state information

    KAUST Repository

    Zenaidi, Mohamed Ridha

    2016-07-26

    In energy harvesting communications, the transmitters have to adapt transmission to availability of energy harvested during the course of communication. The performance of the transmission depends on the channel conditions which vary randomly due to mobility and environmental changes. In this paper, we consider the problem of power allocation taking into account the energy arrivals over time and the degree of channel state information (CSI) available at the transmitter, in order to maximize the throughput. Differently from previous work, the CSI at the transmitter is not perfect and may include estimation errors. We solve this problem with respect to the causality and energy storage constraints. We determine the optimal offline policy in the case where the channel is assumed to be perfectly known at the receiver. Also, we obtain the power policy when the transmitter has no CSI. Furthermore, we analyze the asymptotic average throughput in a system where the average recharge rate goes asymptotically to zero. © 2016 IEEE.

  15. Associating optical measurements and estimating orbits of geocentric objects with a Genetic Algorithm: performance limitations.

    Science.gov (United States)

    Zittersteijn, Michiel; Schildknecht, Thomas; Vananti, Alessandro; Dolado Perez, Juan Carlos; Martinot, Vincent

    2016-07-01

    Currently several thousands of objects are being tracked in the MEO and GEO regions through optical means. With the advent of improved sensors and a heightened interest in the problem of space debris, it is expected that the number of tracked objects will grow by an order of magnitude in the near future. This research aims to provide a method that can treat the correlation and orbit determination problems simultaneously, and is able to efficiently process large data sets with minimal manual intervention. This problem is also known as the Multiple Target Tracking (MTT) problem. The complexity of the MTT problem is defined by its dimension S. Current research tends to focus on the S = 2 MTT problem. The reason for this is that for S = 2 the problem has a P-complexity. However, with S = 2 the decision to associate a set of observations is based on the minimum amount of information, in ambiguous situations (e.g. satellite clusters) this will lead to incorrect associations. The S > 2 MTT problem is an NP-hard combinatorial optimization problem. In previous work an Elitist Genetic Algorithm (EGA) was proposed as a method to approximately solve this problem. It was shown that the EGA is able to find a good approximate solution with a polynomial time complexity. The EGA relies on solving the Lambert problem in order to perform the necessary orbit determinations. This means that the algorithm is restricted to orbits that are described by Keplerian motion. The work presented in this paper focuses on the impact that this restriction has on the algorithm performance.

  16. 3D MODELING OF INDUSTRIAL HERITAGE BUILDING USING COTSs SYSTEM: TEST, LIMITS AND PERFORMANCES

    Directory of Open Access Journals (Sweden)

    M. Piras

    2017-08-01

    Full Text Available The role of UAV systems in applied geomatics is continuously increasing in several applications as inspection, surveying and geospatial data. This evolution is mainly due to two factors: new technologies and new algorithms for data processing. About technologies, from some years ago there is a very wide use of commercial UAV even COTSs (Commercial On-The-Shelf systems. Moreover, these UAVs allow to easily acquire oblique images, giving the possibility to overcome the limitations of the nadir approach related to the field of view and occlusions. In order to test potential and issue of COTSs systems, the Italian Society of Photogrammetry and Topography (SIFET has organised the SBM2017, which is a benchmark where all people can participate in a shared experience. This benchmark, called “Photogrammetry with oblique images from UAV: potentialities and challenges”, permits to collect considerations from the users, highlight the potential of these systems, define the critical aspects and the technological challenges and compare distinct approaches and software. The case study is the “Fornace Penna” in Scicli (Ragusa, Italy, an inaccessible monument of industrial architecture from the early 1900s. The datasets (images and video have been acquired from three different UAVs system: Parrot Bebop 2, DJI Phantom 4 and Flytop Flynovex. The aim of this benchmark is to generate the 3D model of the “Fornace Penna”, making an analysis considering different software, imaging geometry and processing strategies. This paper describes the surveying strategies, the methodologies and five different photogrammetric obtained results (sensor calibration, external orientation, dense point cloud and two orthophotos, using separately – the single images and the frames extracted from the video – acquired with the DJI system.

  17. Effect of mass transfer limitations on catalyst performance during reduction and carburization of iron based Fischer-Tropsch synthesis catalysts

    Institute of Scientific and Technical Information of China (English)

    Akbar; Zamaniyan; Yadollah; Mortazavi; Abbas; Ali; Khodadadi; Ali; Nakhaei; Pour

    2013-01-01

    Existence of intraparticle mass transfer limitations under typical Fischer-Tropsch synthesis has been reported previously,but there is no suitable study on the existence of intraparticle diffusion limitations under pretreatment steps (reduction and activation) and their effect on catalytic performance for iron based catalysts.In this study,Fe-Cu-La-SiO2 catalysts were prepared by co-precipitation method.To investigate the intraparticle mass transfer limitation under reduction,activation and reaction steps,and its effect on catalytic performance,catalyst pellets with different sizes of 6,3,1 and 0.5 mm have been prepared.All catalysts were calcined,pretreated and tested under similar conditions.The catalysts were activated in hydrogen (5%H2in N2) at 450℃ for 3 h and exposed to syngas (H2/CO=1) at 270℃ and atmospheric pressure for 40 h.Afterwards,FTS reaction tests were performed for approximately 120 h to reach steady state conditions at 290℃,17 bar and a feed flow (syngas H2/CO=1) rate of 3 L/h (STP).Using small pellets resulted in higher CO conversion,FT reaction rate and C5+ productivity as compared with larger pellets.The small pellets reached steady state conditions just 20 h after starting the reaction.Whereas for larger pellets,CO conversion,FT reaction rate and C5+ productivity increased gradually,and reached steady state and maximum values after 120 h of operation.The results illustrate that mass transfer limitations exist not only for FTS reaction but also for the reduction and carburization steps which lead to various phase formation through catalyst activation.Also the results indicate that some effects of mass transfer limitations in activation step,can be compensated in the reaction step.The results can be used for better design of iron based catalyst to improve the process economy.

  18. Assessing control of postural stability in community-living older adults using performance-based limits of stability

    DEFF Research Database (Denmark)

    Jbabdi, Myriam; Boissy, Patrice; Hamel, Mathieu

    2008-01-01

    . Results showed that a motor learning effect was present as the participants optimized their weight-shifting strategy through the first three trials of each task using the visual biofeedback provided on their COP. Reliable measures of control of postural stability at performance-based LOS can be obtained...... during weight-shifting postural tasks with real time visual feedback of the COP displacement to assess postural stability of community-living older adults. In order to obtain reliable results, a learning phase allowing subjects to learn how to control their COP displacement is needed.......BACKGROUND: Balance disability measurements routinely used to identify fall risks in frail populations have limited value in the early detection of postural stability deficits in community-living older adults. The objectives of the study were to 1) measure performance-based limits of stability (LOS...

  19. [Aviation and high-altitude medicine for anaesthetists. Part 4: human performance limitations and crew resource management].

    Science.gov (United States)

    Egerth, Martin; Pump, Stefan; Graf, Jürgen

    2013-06-01

    For pilots and doctors, as well as a variety of other professions the knowledge of human performance limitations is essential, especially in critical situations. Crew resource management was developed in the 1980s in the aviation industry in order to ensure systematic training and support in such instances. Just recently, the value is recognized not only in other high reliability organizations but also in medicine. © Georg Thieme Verlag Stuttgart · New York.

  20. Multiple Antennas Systems and Full Duplex Relay Systems with Hardware Impairments: New Performance Limits

    KAUST Repository

    Javed, Sidrah

    2016-12-01

    Next generation of wireless communication mostly relies on multiple-input multipleoutput (MIMO) configuration and full-duplex relaying to improve data-rates, spectrale efficiency, spatial-multiplexing, quality-of-service and energy-efficiency etc. However, multiple radio frequency (RF) transceivers in MIMO system and multi-hops in relay networks, accumulate transceiver impairments, rendering an unacceptable system performance. Majority of the technical contributions either assume ideal hardware or inappropriately model hardware impairments which often induce misleading results especially for high data-rate communication systems. We propose statistical mathematical modeling of various hardware impairment (HWI) to characterize their deteriorating effects on the information signal. In addition, we model the aggregate HWI as improper Gaussian signaling (IGS), to fully characterize their asymmetric properties and the self-interfering signal attribute under I/Q imbalance. The proposed model encourages to adopt asymmetric transmission scheme, as opposed to traditional symmetric signaling. First, we present statistical baseband equivalent mathematical models for general MIMO system and two special scenarios of receive and transmit diversity systems under HWI. Then, we express their achievable rate under PGS and IGS transmit schemes. Moreover, we tune the IGS statistical characteristics to maximize the achievable rate. We also present optimal beam-forming/pre-coding and receive combiner vector for multiple-input single-output (MISO) and single-input multiple output (SIMO) systems, which lead to SDNR maximization. Moreover, we propose an adaptive scheme to switch between maximal IGS (MIGS) and PGS transmission based on the described conditions to reduce computational overhead. Subsequently, two case studies are presented. 1) Outage analysis has been carried out for SIMO, under transceiver distortion noise, for two diversity combining schemes 2) The benefits of employing IGS

  1. Performance Limits of Energy Harvesting Communications under Imperfect Channel State Information

    KAUST Repository

    Zenaidi, Mohamed Ridah

    2015-01-07

    In energy harvesting communications, the transmitters have to adapt transmission to availability of energy harvested during the course of communication. The performance of the transmission depends on the channel conditions which vary randomly due to mobility and environmental changes. In this work, we consider the problem of power allocation taking into account the energy arrivals over time and the degree of channel state information (CSI) available at the transmitter, in order to maximize the throughput. In this work, the CSI at the transmitter is not perfect and may include estimation errors. We solve this problem with respect to the causality and energy storage constraints. We determine the optimal offline policy in the case where the channel is assumed to be perfectly known at the receiver. Different cases of CSI availability are studied for the transmitter. We obtain the power policy when the transmitter has either perfect CSI or no CSI. We also investigate of utmost interest the case of fading channels with imperfect CSI. Furthermore, we analyze the asymptotic average throughput in a system where the average recharge rate goes asymptotically to zero and when it is very high.

  2. Performance Limits of Online Energy Harvesting Communications with Noisy Channel State Information at the Transmitter

    KAUST Repository

    Zenaidi, Mohamed Ridha

    2017-03-01

    In energy harvesting communications, the transceivers have to adjust the data transmission to the energy scavenged during the course of communication. The performance of the transmission depends on the channel conditions which vary randomly due to mobility and environmental changes. In this paper, we consider the problem of power allocation taking into account the energy arrivals over time and the quality of channel state information (CSI) measured at the transmitter, in order to maximize the throughput. Differently from previous work, we focus on energy harvesting communications where the CSI at the transmitter is not perfect and may include estimation errors. In the present paper, we introduce a Markov process that models the energy arrival process. Indeed, we solve the throughput maximization problem with respect to energy harvesting constraints. We show that the optimal online power policy can be found using dynamic programming. Furthermore, we study the asymptotic behavior of the communication system at low and high average recharge rate (ARR) regime. Selected numerical results are provided to support our analysis.

  3. Elucidating the Performance Limitations of Lithium-ion Batteries due to Species and Charge Transport through Five Characteristic Parameters

    Science.gov (United States)

    Jiang, Fangming; Peng, Peng

    2016-01-01

    Underutilization due to performance limitations imposed by species and charge transports is one of the key issues that persist with various lithium-ion batteries. To elucidate the relevant mechanisms, two groups of characteristic parameters were proposed. The first group contains three characteristic time parameters, namely: (1) te, which characterizes the Li-ion transport rate in the electrolyte phase, (2) ts, characterizing the lithium diffusion rate in the solid active materials, and (3) tc, describing the local Li-ion depletion rate in electrolyte phase at the electrolyte/electrode interface due to electrochemical reactions. The second group contains two electric resistance parameters: Re and Rs, which represent respectively, the equivalent ionic transport resistance and the effective electronic transport resistance in the electrode. Electrochemical modeling and simulations to the discharge process of LiCoO2 cells reveal that: (1) if te, ts and tc are on the same order of magnitude, the species transports may not cause any performance limitations to the battery; (2) the underlying mechanisms of performance limitations due to thick electrode, high-rate operation, and large-sized active material particles as well as effects of charge transports are revealed. The findings may be used as quantitative guidelines in the development and design of more advanced Li-ion batteries. PMID:27599870

  4. Wireless Physical Layer Security: On the Performance Limit of Secret-Key Agreement

    KAUST Repository

    Zorgui, Marwen

    2015-05-01

    Physical layer security (PLS) is a new paradigm aiming at securing communications between legitimate parties at the physical layer. Conventionally, achieving confidentiality in communication networks relies on cryptographic techniques such as public-key cryptography, secret-key distribution and symmetric encryption. Such techniques are deemed secure based on the assumption of limited computational abilities of a wiretapper. Given the relentless progress in computational capacities and the dynamic topology and proliferation of modern wireless networks, the relevance of the previous techniques in securing communications is more and more questionable and less and less reliable. In contrast to this paradigm, PLS does not assume a specific computational power at any eavesdropper, its premise to guarantee provable security via employing channel coding techniques at the physical layer exploiting the inherent randomness in most communication systems. In this dissertation, we investigate a particular aspect of PLS, which is secret-key agreement, also known as secret-sharing. In this setup, two legitimate parties try to distill a secret-key via the observation of correlated signals through a noisy wireless channel, in the presence of an eavesdropper who must be kept ignorant of the secret-key. Additionally, a noiseless public channel is made available to the legitimate parties to exchange public messages that are also accessible to the eavesdropper. Recall that key agreement is an important aspect toward realizing secure communications in the sense that the key can be used in a one-time pad scheme to send the confidential message. In the first part, our focus is on secret-sharing over Rayleigh fading quasi-static channels. We study the fundamental relationship relating the probability of error and a given target secret-key rate in the high power regime. This is characterized through the diversity multiplexing tradeoff (DMT) concept, that we define for our model and then

  5. Performance limitation and the role of core temperature when wearing light-weight workwear under moderate thermal conditions.

    Science.gov (United States)

    Kofler, Philipp; Burtscher, Martin; Heinrich, Dieter; Bottoni, Giuliamarta; Caven, Barnaby; Bechtold, Thomas; Teresa Herten, Anne; Hasler, Michael; Faulhaber, Martin; Nachbauer, Werner

    2015-01-01

    The objective of this investigation was to achieve an understanding about the relationship between heat stress and performance limitation when wearing a two-layerfire-resistant light-weight workwear (full-clothed ensemble) compared to an one-layer short sports gear (semi-clothed ensemble) in an exhaustive, stressful situation under moderate thermal condition (25°C). Ten well trained male subjects performed a strenuous walking protocol with both clothing ensembles until exhaustion occurred in a climatic chamber. Wearing workwear reduced the endurance performance by 10% (p=0.007) and the evaporation by 21% (p=0.003), caused a more pronounced rise in core temperature during submaximal walking (0.7±0.3 vs. 1.2±0.4°C; p≤0.001) and from start till exhaustion (1.4±0.3 vs. 1.8±0.5°C; p=0.008), accelerated sweat loss (13±2 vs. 15±3gmin(-1); p=0.007), and led to a significant higher heart rate at the end of cool down (103±6 vs. 111±7bpm; p=0.004). Correlation analysis revealed that core temperature development during submaximal walking and evaporation may play important roles for endurance performance. However, a critical core temperature of 40°C, which is stated to be a crucial factor for central fatigue and performance limitation, was not reached either with the semi-clothed or the full-clothed ensemble (38.3±0.4 vs. 38.4±0.5°C). Additionally, perceived exertion did not increase to a higher extent parallel with the rising core temperature with workwear which would substantiate the critical core temperature theory. In conclusion, increased heat stress led to cardiovascular exercise limitation rather than central fatigue. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Kinetic performance limits of constant pressure versus constant flow rate gradient elution separations. Part I: theory.

    Science.gov (United States)

    Broeckhoven, K; Verstraeten, M; Choikhet, K; Dittmann, M; Witt, K; Desmet, G

    2011-02-25

    We report on a general theoretical assessment of the potential kinetic advantages of running LC gradient elution separations in the constant-pressure mode instead of in the customarily used constant-flow rate mode. Analytical calculations as well as numerical simulation results are presented. It is shown that, provided both modes are run with the same volume-based gradient program, the constant-pressure mode can potentially offer an identical separation selectivity (except from some small differences induced by the difference in pressure and viscous heating trajectory), but in a significantly shorter time. For a gradient running between 5 and 95% of organic modifier, the decrease in analysis time can be expected to be of the order of some 20% for both water-methanol and water-acetonitrile gradients, and only weakly depending on the value of V(G)/V₀ (or equivalently t(G)/t₀). Obviously, the gain will be smaller when the start and end composition lie closer to the viscosity maximum of the considered water-organic modifier system. The assumptions underlying the obtained results (no effects of pressure and temperature on the viscosity or retention coefficient) are critically reviewed, and can be inferred to only have a small effect on the general conclusions. It is also shown that, under the adopted assumptions, the kinetic plot theory also holds for operations where the flow rate varies with the time, as is the case for constant-pressure operation. Comparing both operation modes in a kinetic plot representing the maximal peak capacity versus time, it is theoretically predicted here that both modes can be expected to perform equally well in the fully C-term dominated regime (where H varies linearly with the flow rate), while the constant pressure mode is advantageous for all lower flow rates. Near the optimal flow rate, and for linear gradients running from 5 to 95% organic modifier, time gains of the order of some 20% can be expected (or 25-30% when accounting for

  7. Modeling and Validation of Performance Limitations for the Optimal Design of Interferometric and Intensity-Modulated Fiber Optic Displacement Sensors

    Energy Technology Data Exchange (ETDEWEB)

    Moro, Erik A. [Los Alamos National Laboratory

    2012-06-07

    -modulated interferometric sensor depends on an appropriate performance function (e.g., desired displacement range, accuracy, robustness, etc.). In this dissertation, the performance limitations of a bundled differential intensity-modulated displacement sensor are analyzed, where the bundling configuration has been designed to optimize performance. The performance limitations of a white light Fabry-Perot displacement sensor are also analyzed. Both these sensors are non-contacting, but they have access to different regions of the performance-space. Further, both these sensors have different degrees of sensitivity to experimental uncertainty. Made in conjunction with careful analysis, the decision of which sensor to deploy need not be an uninformed one.

  8. BER Performance Simulation of Generalized MC DS-CDMA System with Time-Limited Blackman Chip Waveform

    Directory of Open Access Journals (Sweden)

    I. Develi

    2010-09-01

    Full Text Available Multiple access interference encountered in multicarrier direct sequence-code division multiple access (MC DS-CDMA is the most important difficulty that depends mainly on the correlation properties of the spreading sequences as well as the shape of the chip waveforms employed. In this paper, bit error rate (BER performance of the generalized MC DS-CDMA system that employs time-limited Blackman chip waveform is presented for Nakagami-m fading channels. Simulation results show that the use of Blackman chip waveform can improve the BER performance of the generalized MC DS-CDMA system, as compared to the performances achieved by using timelimited chip waveforms in the literature.

  9. Between Action and Act: On the 9-N in Catalonia’s and the Limits of Performativity

    Directory of Open Access Journals (Sweden)

    Begonya Sáez Tajafuerce

    2017-07-01

    Full Text Available By referring to Michel Foucault’s and Jacques Lacan’s works, and also taking as reference the popular consultation which took place in Cataluña on november 9th 2014, the purpose of this article is to draw the limits of Judith Butler’s theory of performativity with respect to the subject of the political and its agency. Those limits are made manifest by the distinction between political action and act or between subversion, understood as a transgression of the norm which gives place to the reconfiguration of the socio-symbolic order, and interruption, understood as a transgression of the norm which constitutes an event of a radically different order.

  10. MASS TRANSFER LIMITATION IN DIFFERENT ANODE ELECTRODE SURFACE AREAS ON THE PERFORMANCE OF DUAL CHAMBER MICROBIAL FUEL CELL

    Directory of Open Access Journals (Sweden)

    Majid Sadeqzadeh

    2012-01-01

    Full Text Available In this study, the effect of different electrode surface areas on the performance of dual chamber Microbial Fuel Cells (MFC was investigated. Four different electrodes with 12, 16, 20 and 24 cm2 surface areas were tested in an MFC system. The 20 cm2 electrode generated an output power of 76.5 mW/m2 was found to be the highest among all the electrodes tested. This might be due to better interactions with microorganism and less mass transfer limitation. In addition, this indicates that the chances for attachment of bacteria and generation of electricity in larger electrode surface areas might be limited by mass transport and by higher surface area. The output power generation was then followed by the 16, 12 and 24 cm2 electrodes which generated 69.6, 64.7 and 61.25 mW/m2 electricity, respectively.

  11. Performance evaluation of multilevel modulation formats using partial response for capacity upgrade in access network with limited electronic bandwidth

    DEFF Research Database (Denmark)

    Madsen, Peter; Suhr, Lau Frejstrup; Rodríguez Páez, Juan Sebastián

    2016-01-01

    We present a successful experimental evaluation of 4 level Pulse Amplitude Modulation (4-PAM) and Duobinary modulation. An experimental performance evaluation is presented for Duobinary 4 PAM and other modulation formats. All modulation formants used, may be considered to be implemented in future...... Passive Optical Network (PON) class access networks with limited electrical bandwidth. We compared NRZ, Duobinary, 4-PAM and Duobinary 4-PAM operating at 9 Gbaud over 20 km single mode fiber. The results provides an insight and guidelines on the utilization of these advanced modulation formats....

  12. Performance evaluation of multilevel modulation formats using partial response for capacity upgrade in access network with limited electronic bandwidth

    Science.gov (United States)

    Madsen, Peter; Frejstrup Suhr, Lau; Sebastian Rodriguez, Juan; Tafur Monroy, Idelfonso; Vegas Olmos, Juan José

    2016-09-01

    We present a successful experimental evaluation of 4 level Pulse Amplitude Modulation (4-PAM) and Duobinary modulation. An experimental performance evaluation is presented for Duobinary 4 PAM and other modulation formats. All modulation formants used, may be considered to be implemented in future Passive Optical Network (PON) class access networks with limited electrical bandwidth. We compared NRZ, Duobinary, 4-PAM and Duobinary 4-PAM operating at 9 Gbaud over 20 km single mode fiber. The results provides an insight and guidelines on the utilization of these advanced modulation formats.

  13. Modeling the Performance Limitations and Prospects of Perovskite/Si Tandem Solar Cells under Realistic Operating Conditions.

    Science.gov (United States)

    Futscher, Moritz H; Ehrler, Bruno

    2017-09-08

    Perovskite/Si tandem solar cells have the potential to considerably out-perform conventional solar cells. Under standard test conditions, perovskite/Si tandem solar cells already outperform the Si single junction. Under realistic conditions, however, as we show, tandem solar cells made from current record cells are hardly more efficient than the Si cell alone. We model the performance of realistic perovskite/Si tandem solar cells under real-world climate conditions, by incorporating parasitic cell resistances, nonradiative recombination, and optical losses into the detailed-balance limit. We show quantitatively that when optimizing these parameters in the perovskite top cell, perovskite/Si tandem solar cells could reach efficiencies above 38% under realistic conditions, even while leaving the Si cell untouched. Despite the rapid efficiency increase of perovskite solar cells, our results emphasize the need for further material development, careful device design, and light management strategies, all necessary for highly efficient perovskite/Si tandem solar cells.

  14. Analytical performance, reference values and decision limits. A need to differentiate between reference intervals and decision limits and to define analytical quality specifications.

    Science.gov (United States)

    Petersen, Per Hyltoft; Jensen, Esther A; Brandslund, Ivan

    2011-12-23

    With the increasing use of decision limits (action limits, cut-off points) specified for a number of analytical components in diagnosis and for action in critical situations, formulated in national or international recommendations, the traditional interpretation of reference intervals has been uncertain, and sometimes the two concepts are being mixed up by incorporating risk calculations in the reference intervals. There is, therefore, a need to clarify the two concepts and to keep them definitely separated. Reference intervals are the 95% limits for the descriptions of the distributions of the values of analytical components measured on reference samples from reference individuals. Decision limits are based on guidelines from national and international expert groups defining specific concentrations of certain components as limits for decision about diagnosis or well-defined specific actions. Analytical quality specifications for reference intervals have been defined for bias since the 1990s, but in the recommendations specified in the clinical guidelines analytical quality specifications are only scarcely defined. The demands for negligible biases are, however, even more essential for decision limits, as the choice is no longer left to the clinician, but emerge directly from the concentration. Even a small bias will change the number of diseased individuals, so the demands for negligible biases are obvious. A view over the analytical quality as published gives a variable picture of bias for many components, but with many examples of considerable bias which must be critical--yet no specifications have been stipulated until now.

  15. A minimal limit-cycle model to profile movement patterns of individuals during agility drill performance: Effects of skill level.

    Science.gov (United States)

    Mehdizadeh, Sina; Arshi, Ahmed Reza; Davids, Keith

    2015-06-01

    Identification of control strategies during agility performance is significant in understanding movement behavior. This study aimed at providing a fundamental mathematical model for describing the motion of participants during an agility drill and to determine whether skill level constrained model components. Motion patterns of two groups of skilled and unskilled participants (n=8 in each) during performance of a forward/backward agility drill modeled as limit-cycles. Participant movements were recorded by motion capture of a reflective marker attached to the sacrum of each individual. Graphical and regression analyses of movement kinematics in Hooke's plane, phase plane and velocity profile were performed to determine components of the models. Results showed that the models of both skilled and unskilled groups had terms from Duffing stiffness as well as Van der Pol damping oscillators. Data also indicated that the proposed models captured on average 97% of the variance for both skilled and unskilled groups. Findings from this study revealed the movement patterning associated with skilled and unskilled performance in a typical forward/backward agility drill which might be helpful for trainers and physiotherapists in enhancing agility.

  16. Application of a modified flux-coupling type superconducting fault current limiter to transient performance enhancement of micro-grid

    Science.gov (United States)

    Chen, Lei; Zheng, Feng; Deng, Changhong; Li, Shichun; Li, Miao; Liu, Hui; Zhu, Lin; Guo, Fang

    2015-11-01

    Concerning the application and development of a micro-grid system which is designed to accommodate high penetration of intermittent renewable resources, one of the main issues is related to an increase in the fault-current level. It is crucial to ensure the micro-grid's operational stability and service reliability when a fault occurs in the main network. In this paper, our research group suggests a modified flux-coupling type superconducting fault current limiter (SFCL) to enhance the transient performance of a typical micro-grid system. The SFCL is installed at the point of common coupling (PCC) between the main network and the micro-grid, and it is expected to actively improve the micro-grid's fault ride-through capability. And for some specific faults, the micro-grid should disconnect from the main network, and the SFCL's contribution is to make the micro-grid carry out a smooth transition between its grid-connected and islanded modes. Related theory derivation, technical discussion and simulation analysis are performed. From the demonstrated results, applying the SFCL can effectively limit the fault current, maintain the power balance, and enhance the voltage and frequency stability of the micro-grid.

  17. Revisiting Pocos de Caldas. Application of the co-precipitation approach to establish realistic solubility limits for performance assessment

    Energy Technology Data Exchange (ETDEWEB)

    Bruno, J.; Duro, L.; Jordana, S.; Cera, E. [QuantiSci, Barcelona (Spain)

    1996-02-01

    Solubility limits constitute a critical parameter for the determination of the mobility of radionuclides in the near field and the geosphere, and consequently for the performance assessment of nuclear waste repositories. Mounting evidence from natural system studies indicate that trace elements, and consequently radionuclides, are associated to the dynamic cycling of major geochemical components. We have recently developed a thermodynamic approach to take into consideration the co-precipitation and co-dissolution processes that mainly control this linkage. The approach has been tested in various natural system studies with encouraging results. The Pocos de Caldas natural analogue was one of the sites where a full testing of our predictive geochemical modelling capabilities were done during the analogue project. We have revisited the Pocos de Caldas data and expanded the trace element solubility calculations by considering the documented trace metal/major ion interactions. This has been done by using the co-precipitation/co-dissolution approach. The outcome is as follows: A satisfactory modelling of the behaviour of U, Zn and REEs is achieved by assuming co-precipitation with ferrihydrite. Strontium concentrations are apparently controlled by its co-dissolution from Sr-rich fluorites. From the performance assessment point of view, the present work indicates that calculated solubility limits using the co-precipitation approach are in close agreement with the actual trace element concentrations. Furthermore, the calculated radionuclide concentrations are 2-4 orders of magnitude lower than conservative solubility limits calculated by assuming equilibrium with individual trace element phases. 34 refs, 18 figs, 13 tabs.

  18. Analytical performance, reference values and decision limits. A need to differentiate between reference intervals and decision limits and to define analytical quality specifications

    DEFF Research Database (Denmark)

    Petersen, Per Hyltoft; Jensen, Esther A; Brandslund, Ivan

    2012-01-01

    With the increasing use of decision limits (action limits, cut-off points) specified for a number of analytical components in diagnosis and for action in critical situations, formulated in national or international recommendations, the traditional interpretation of reference intervals has been....... Analytical quality specifications for reference intervals have been defined for bias since the 1990s, but in the recommendations specified in the clinical guidelines analytical quality specifications are only scarcely defined. The demands for negligible biases are, however, even more essential for decision...

  19. Application of a modified flux-coupling type superconducting fault current limiter to transient performance enhancement of micro-grid

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lei, E-mail: stclchen1982@163.com [School of Electrical Engineering, Wuhan University, Wuhan 430072 (China); Zheng, Feng; Deng, Changhong; Li, Shichun; Li, Miao; Liu, Hui [School of Electrical Engineering, Wuhan University, Wuhan 430072 (China); Zhu, Lin [Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville 37996 (United States); Guo, Fang [Department of Substation, Guang Dong Electric Power Design Institute, Guangzhou 510663 (China)

    2015-11-15

    Highlights: • A modified flux-coupling type SFCL is suggested to enhance the transient performance of a micro-grid. • The SFCL’s main contribution is to improve the micro-grid’s fault ride-through capability. • The SFCL also can make the micro-grid carry out a smooth transition between its grid-connected and islanded modes. • The simulations show that the SFCL can availably strengthen the micro-grid’s voltage and frequency stability. - Abstract: Concerning the application and development of a micro-grid system which is designed to accommodate high penetration of intermittent renewable resources, one of the main issues is related to an increase in the fault-current level. It is crucial to ensure the micro-grid’s operational stability and service reliability when a fault occurs in the main network. In this paper, our research group suggests a modified flux-coupling type superconducting fault current limiter (SFCL) to enhance the transient performance of a typical micro-grid system. The SFCL is installed at the point of common coupling (PCC) between the main network and the micro-grid, and it is expected to actively improve the micro-grid’s fault ride-through capability. And for some specific faults, the micro-grid should disconnect from the main network, and the SFCL’s contribution is to make the micro-grid carry out a smooth transition between its grid-connected and islanded modes. Related theory derivation, technical discussion and simulation analysis are performed. From the demonstrated results, applying the SFCL can effectively limit the fault current, maintain the power balance, and enhance the voltage and frequency stability of the micro-grid.

  20. THE CHALLENGES OF CORPORATE GOVERNANCE AND AUDIT IN RELATION TO FINANCIAL PERFORMANCE – TRENDS, LIMITATIONS AND DIRECTIONS TO FOLLOW

    Directory of Open Access Journals (Sweden)

    Alexandra Narcisa CIOBAN (LUCAN

    2016-12-01

    Full Text Available Through this paper we propose to identify and present the latest trends in valuing the corporate governance and audit features in relation to the company performance, measured in financial terms. Our research is qualitative, as it covers a wide range of approache from the perspective of academics and practitioners in the field. In this regard, we consulted the most important resources in the world scientific electronic documentation, such as: Thomson Reuters Web of Science, SpringerLink platform, PROQUEST Central, Oxford Journals, Emerald Journals and other research platforms. The contribution of this research it is valuable both for researchers in the area of financial accounting and practitioners, and aims to identify the recent challenges of the corporate governance and audit in influencing the financial performance of major companies around the world. We analyzed a variety of scientific publications on this subject, more than 70 empirical studies conducted in the US, China, Russia, Japan, India, Malaysia, the Arab countries, UK, Germany, Spain, Romania, etc. After having conducted the research, we carried out a platform with representative variables for corporate governance, audit and financial performance which will serve for future studies in the field. This will facilitate the researchers’ choice for building econometric analysis models since we also surprised existing limitations.

  1. Breaking the speed limit--comparative sprinting performance of brook trout (Salvelinus fontinalis) and brown trout (Salmo trutta)

    Science.gov (United States)

    Castro-Santos, Theodore; Sanz-Ronda, Francisco Javier; Ruiz-Legazpi, Jorge

    2013-01-01

    Sprinting behavior of free-ranging fish has long been thought to exceed that of captive fish. Here we present data from wild-caught brook trout (Salvelinus fontinalis) and brown trout (Salmo trutta), volitionally entering and sprinting against high-velocity flows in an open-channel flume. Performance of the two species was nearly identical, with the species attaining absolute speeds > 25 body lengths·s−1. These speeds far exceed previously published observations for any salmonid species and contribute to the mounting evidence that commonly accepted estimates of swimming performance are low. Brook trout demonstrated two distinct modes in the relationship between swim speed and fatigue time, similar to the shift from prolonged to sprint mode described by other authors, but in this case occurring at speeds > 19 body lengths·s−1. This is the first demonstration of multiple modes of sprint swimming at such high swim speeds. Neither species optimized for distance maximization, however, indicating that physiological limits alone are poor predictors of swimming performance. By combining distributions of volitional swim speeds with endurance, we were able to account for >80% of the variation in distance traversed by both species.

  2. Analysis of Performance Limitations in Fiber Bragg Grating Based Optical Add-Drop Multiplexer due to Crosstalk

    Directory of Open Access Journals (Sweden)

    Md. Mahiuddin

    2012-03-01

    Full Text Available Abstract— Wavelength  division  multiplexing  (WDM optical networks  are  attracting  more  and  more attention because of their ability to provide  increased capacity and  flexibility. Optical add-drop multiplexer (OADM  becomes  a  key  component  to  add  or  drop wavelengths  in  high  bit  rate  optical  networks. Crosstalk  in OADM  often degrades  the performance of WDM  system  drastically.  In  this  article,  we  have developed  analytical model  for  low  crosstalk  of  fiber Bragg  grating  based  OADM  with  isolator. We  have also  derived  analytical  expressions  for  relative intensity noise (RIN, bit error rate (BER and power penalty to evaluate the performance limitations of this OADM. Results show that crosstalk, RIN and BER of the  proposed  OADM  are significantly  lower  and provide better performance than the existing OADMs.

  3. Growth performance and carcass characteristics of korean native ducks fed diets with varying levels of limiting amino acids.

    Science.gov (United States)

    Choo, Y K; Kwon, H J; Oh, S T; Kang, C W; Kim, H K; Hong, E C; Heo, K N; Lee, S K; An, B K

    2014-04-01

    There are multiple experiments conducted with male Korean native ducks (KND) to evaluate the optimal levels of limiting amino acids (AA). In Exp. 1, a total of 450 one-d-old male KNDs were divided into five groups with six replicates and fed experimental diets with varying levels of lysine, total sulfur amino acids (TSAA) and threonine (T1, 0.90/0.74/0.70%; T2, 1.00/0.82/0.77%; T3, 1.10/0.90/0.85%; T4, 1.20/0.98/0.93%; T5, 1.30/1.07/1.01%) to 21 d of age. In Exp. 2, one-d-old male KND were received and fed commercial starter diet from hatching to 21 d of age, and then divided into five groups with six replicates and fed one of five diets varying levels of lysine, TSAA, and threonine (T1, 0.73/0.62/0.54%; T2, 0.80/0.68/0.60%; T3, 0.87/0.74/0.65%; T4, 0.94/0.80/0.70%; T5, 1.01/0.86/0.75%) during 22 to 56 d of age, respectively. The BW gain was linearly increased as dietary limiting AA levels increased to 1.20% lysine, 0.98% TSAA and 0.93% threonine. There were no significant differences in feed intake, gain:feed and uniformity among groups. In Exp. 2, the BW gain and gain:feed were not affected by dietary limiting AA levels. There were no significant differences in carcass characteristics and meat quality among groups. The growth performance and carcass characteristics did not show the significant response to increasing dietary limiting AA levels in KND during 22 to 56 d of age. In conclusion, the levels of lysine, TSAA and threonine necessary to maximize growth for starter phase were at least 1.20%, 0.98%, and 0.93%, respectively. On the other hands, KND require relatively low levels of limiting AA for late growth and carcass yield. The dietary levels of 0.73% lysine, 0.62% TSAA and 0.54% threonine appear to be adequate during growing phase.

  4. Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.

    Science.gov (United States)

    Lyman, Kyle A; Han, Ye; Heuermann, Robert J; Cheng, Xiangying; Kurz, Jonathan E; Lyman, Reagan E; Van Veldhoven, Paul P; Chetkovich, Dane M

    2017-09-08

    Tetratricopeptide repeat (TPR) domains are ubiquitous structural motifs that mediate protein-protein interactions. For example, the TPR domains in the peroxisomal import receptor PEX5 enable binding to a range of type 1 peroxisomal targeting signal (PTS1) motifs. A homolog of PEX5, tetratricopeptide repeat-containing Rab8b interacting protein (TRIP8b), binds to and functions as an auxiliary subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Given the similarity between TRIP8b and PEX5, this difference in function raises the question of what mechanism accounts for their binding specificity. In this report, we found that the cyclic nucleotide-binding domain (CNBD) and the C-terminus of the HCN channel are critical for conferring specificity to TRIP8b binding. We show that TRIP8b binds the HCN CNBD through a 37-residue domain and the HCN C-terminus through the TPR domains. Using a combination of fluorescence polarization and co-immunoprecipitation based assays, we establish that binding at either site increases affinity at the other. Thus, allosteric coupling of the TRIP8b TPR domains both promotes binding to HCN channels and limits binding to PTS1 substrates. These results raise the possibility that other TPR domains may similarly be influenced by allosteric mechanisms as a general feature of protein-protein interactions. Copyright © 2017, The American Society for Biochemistry and Molecular Biology.

  5. Performance limit of a multi-frequency probe based coherent optical time domain reflectometry caused by nonlinear effects

    Institute of Scientific and Technical Information of China (English)

    Lidong Lü; Yuejiang Song; Fan Zhu; Xuping Zhang

    2012-01-01

    The nonlinear effects that limit the performance of the multi-frequency probe (MFP) based coherent optical time domain reflectometry (C-OTDR) are investigated.Based on theoretical analysis and experimental results,compared with conventional C-OTDR,when the probe pulse has power gradient within the pulse width,self-phase modulation (SPM) and cross-phase modulation (XPM) are strengthened in the new COTDR scheme.The generation of four-wave mixing (FWM) is dependent on SPM and XPM,and with modulation frequency of phase modulator higher than 40 MHz,the stimulated Brillouin scattering (SBS) threshold can be enhanced by more than 5 dB,which benefits the maximum dynamic range of the MFP C-OTDR.

  6. Predicting classifier performance with limited training data: applications to computer-aided diagnosis in breast and prostate cancer.

    Directory of Open Access Journals (Sweden)

    Ajay Basavanhally

    Full Text Available Clinical trials increasingly employ medical imaging data in conjunction with supervised classifiers, where the latter require large amounts of training data to accurately model the system. Yet, a classifier selected at the start of the trial based on smaller and more accessible datasets may yield inaccurate and unstable classification performance. In this paper, we aim to address two common concerns in classifier selection for clinical trials: (1 predicting expected classifier performance for large datasets based on error rates calculated from smaller datasets and (2 the selection of appropriate classifiers based on expected performance for larger datasets. We present a framework for comparative evaluation of classifiers using only limited amounts of training data by using random repeated sampling (RRS in conjunction with a cross-validation sampling strategy. Extrapolated error rates are subsequently validated via comparison with leave-one-out cross-validation performed on a larger dataset. The ability to predict error rates as dataset size increases is demonstrated on both synthetic data as well as three different computational imaging tasks: detecting cancerous image regions in prostate histopathology, differentiating high and low grade cancer in breast histopathology, and detecting cancerous metavoxels in prostate magnetic resonance spectroscopy. For each task, the relationships between 3 distinct classifiers (k-nearest neighbor, naive Bayes, Support Vector Machine are explored. Further quantitative evaluation in terms of interquartile range (IQR suggests that our approach consistently yields error rates with lower variability (mean IQRs of 0.0070, 0.0127, and 0.0140 than a traditional RRS approach (mean IQRs of 0.0297, 0.0779, and 0.305 that does not employ cross-validation sampling for all three datasets.

  7. Impact of quantum confinement on transport and the electrostatic driven performance of silicon nanowire transistors at the scaling limit

    Science.gov (United States)

    Al-Ameri, Talib; Georgiev, Vihar P.; Sadi, Toufik; Wang, Yijiao; Adamu-Lema, Fikru; Wang, Xingsheng; Amoroso, Salvatore M.; Towie, Ewan; Brown, Andrew; Asenov, Asen

    2017-03-01

    In this work we investigate the impact of quantum mechanical effects on the device performance of n-type silicon nanowire transistors (NWT) for possible future CMOS applications at the scaling limit. For the purpose of this paper, we created Si NWTs with two channel crystallographic orientations and and six different cross-section profiles. In the first part, we study the impact of quantum corrections on the gate capacitance and mobile charge in the channel. The mobile charge to gate capacitance ratio, which is an indicator of the intrinsic performance of the NWTs, is also investigated. The influence of the rotating of the NWTs cross-sectional geometry by 90° on charge distribution in the channel is also studied. We compare the correlation between the charge profile in the channel and cross-sectional dimension for circular transistor with four different cross-sections diameters: 5 nm, 6 nm, 7 nm and 8 nm. In the second part of this paper, we expand the computational study by including different gate lengths for some of the Si NWTs. As a result, we establish a correlation between the mobile charge distribution in the channel and the gate capacitance, drain-induced barrier lowering (DIBL) and the subthreshold slope (SS). All calculations are based on a quantum mechanical description of the mobile charge distribution in the channel. This description is based on the solution of the Schrödinger equation in NWT cross sections along the current path, which is mandatory for nanowires with such ultra-scale dimensions.

  8. 有限关注与股票市场表现%Limited Attention and Stock Market Performance

    Institute of Scientific and Technical Information of China (English)

    汤祥凤

    2016-01-01

    本文选取股票代码日百度指数作为投资者关注度的衡量指标,实证分析了投资者有限关注与个股市场表现之间的关系。结果显示:投资者的关注会对个股交易量、换手率等市场交易指标带来正的影响;进一步,投资者的关注会造成股票当期收益的溢价,其滞后期则出现反转效应。%Selecting stock code-baidu index as a measure of investors’ attention, the author empirical analyzed the relationship between the investors’ limited attention and individual stock performance. The results showed that investors’ attention to stock market indexes such as volume, turnover rate brings positive effect; Furthermore, investors ’ attention will cause current stock earnings premium while its lag period generated reversal effect.

  9. 'The engine just started coughing!' - Limits of physical performance, aging and career continuity in elite endurance sports.

    Science.gov (United States)

    Ronkainen, Noora J; Ryba, Tatiana V; Nesti, Mark S

    2013-12-01

    This research examines male endurance athletes' experience of aging and/or reaching the perceived limits of physical performance. More specifically, the current study aimed to explore how existential meanings attached to these experiences are connected with athletes' decision-making concerning career continuity and retirement. Life story interviews were conducted with 10 Finnish runners and/or orienteers aged between 25 and 62 and the data was analyzed with an existential-narrative framework. Four major storylines related to aging were identified: The end of an era, putting things in perspective, the attitude has to change and winning was never the only motive. Our results suggest that endurance athletes possess diverse ways of bringing meaning to the experience of aging, both confirming and resisting the dominant cultural narrative of decline. While three athletes' stories confirmed the normativity of retirement when unable to improve their results anymore, other athletes demonstrated career continuity and positive aspects in the late career years, such as lack of competitive anxiety, finding perspective and increased enjoyment in running. We suggest that through awareness of alternative narratives, sport psychology consultants may be able to help their clients to explore new meanings in the potentially challenging and beneficial experiences of aging and athletic retirement. © 2013.

  10. Dynamical properties of liquid water from ab initio molecular dynamics performed in the complete basis set limit

    Science.gov (United States)

    Lee, Hee-Seung; Tuckerman, Mark E.

    2007-04-01

    Dynamical properties of liquid water were studied using Car-Parrinello [Phys. Rev. Lett. 55, 2471 (1985)] ab initio molecular dynamics (AIMD) simulations within the Kohn-Sham (KS) density functional theory employing the Becke-Lee-Yang-Parr exchange-correlation functional for the electronic structure. The KS orbitals were expanded in a discrete variable representation basis set, wherein the complete basis set limit can be easily reached and which, therefore, provides complete convergence of ionic forces. In order to minimize possible nonergodic behavior of the simulated water system in a constant energy (NVE) ensemble, a long equilibration run (30ps) preceded a 60ps long production run. The temperature drift during the entire 60ps trajectory was found to be minimal. The diffusion coefficient [0.055Å2/ps] obtained from the present work for 32 D2O molecules is a factor of 4 smaller than the most up to date experimental value, but significantly larger than those of other recent AIMD studies. Adjusting the experimental result so as to match the finite-sized system used in the present study brings the comparison between theory and experiment to within a factor of 3. More importantly, the system is not observed to become "glassy" as has been reported in previous AIMD studies. The computed infrared spectrum is in good agreement with experimental data, especially in the low frequency regime where the translational and librational motions of water are manifested. The long simulation length also made it possible to perform detailed studies of hydrogen bond dynamics. The relaxation dynamics of hydrogen bonds observed in the present AIMD simulation is slower than those of popular force fields, such as the TIP4P potential, but comparable to that of the TIP5P potential.

  11. Factors limiting performance in a multitone intensity-discrimination task: disentangling non-optimal decision weights and increased internal noise.

    Directory of Open Access Journals (Sweden)

    Daniel Oberfeld

    Full Text Available To identify factors limiting performance in multitone intensity discrimination, we presented sequences of five pure tones alternating in level between loud (85 dB SPL and soft (30, 55, or 80 dB SPL. In the "overall-intensity task", listeners detected a level increment on all of the five tones. In the "masking task", the level increment was imposed only on the soft tones, rendering the soft tones targets and loud tones task-irrelevant maskers. Decision weights quantifying the importance of the five tone levels for the decision were estimated using methods of molecular psychophysics. Compatible with previous studies, listeners placed higher weights on the loud tones than on the soft tones in the overall-intensity condition. In the masking task, the decisions were systematically influenced by the to-be-ignored loud tones (maskers. Using a maximum-likelihood technique, we estimated the internal noise variance and tested whether the internal noise was higher in the alternating-level five-tone sequences than in sequences presenting only the soft or only the loud tones. For the overall-intensity task, we found no evidence for increased internal noise, but listeners applied suboptimal decision weights. These results are compatible with the hypothesis that the presence of the loud tones does not impair the precision of the representation of the intensity of the soft tones available at the decision stage, but that this information is not used in an optimal fashion due to a difficulty in attending to the soft tones. For the masking task, in some cases our data indicated an increase in internal noise. Additionally, listeners applied suboptimal decision weights. The maximum-likelihood analyses we developed should also be useful for other tasks or other sensory modalities.

  12. Advantages and Limitations of Androgen Receptor-Based Methods for Detecting Anabolic Androgenic Steroid Abuse as Performance Enhancing Drugs.

    Science.gov (United States)

    Bailey, Kathy; Yazdi, Tahmineh; Masharani, Umesh; Tyrrell, Blake; Butch, Anthony; Schaufele, Fred

    2016-01-01

    Testosterone (T) and related androgens are performance enhancing drugs (PEDs) abused by some athletes to gain competitive advantage. To monitor unauthorized androgen abuse, doping control programs use mass spectrometry (MS) to detect androgens, synthetic anabolic-androgenic steroids (AASs) and their metabolites in an athlete's urine. AASs of unknown composition will not be detected by these procedures. Since AASs achieve their anabolic effects by activating the Androgen Receptor (AR), cell-based bioassays that measure the effect of a urine sample on AR activity are under investigation as complementary, pan-androgen detection methods. We evaluated an AR BioAssay as a monitor for androgen activity in urine pre-treated with glucuronidase, which releases T from the inactive T-glucuronide that predominates in urine. AR BioAssay activity levels were expressed as 'T-equivalent' concentrations by comparison to a T dose response curve. The T-equivalent concentrations of androgens in the urine of hypogonadal participants supplemented with T (in whom all androgenic activity should arise from T) were quantitatively identical to the T measurements conducted by MS at the UCLA Olympic Analytical Laboratory (0.96 ± 0.22). All 17 AASs studied were active in the AR BioAssay; other steroids were inactive. 12 metabolites of 10 commonly abused AASs, which are used for MS monitoring of AAS doping because of their prolonged presence in urine, had reduced or no AR BioAssay activity. Thus, the AR BioAssay can accurately and inexpensively monitor T, but its ability to monitor urinary AASs will be limited to a period immediately following doping in which the active AASs remain intact.

  13. 25 CFR 12.55 - Are there any limits on how much force an officer can use when performing law enforcement duties?

    Science.gov (United States)

    2010-04-01

    ... when performing law enforcement duties? 12.55 Section 12.55 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY LAW ENFORCEMENT Conduct § 12.55 Are there any limits on how much force an officer can use when performing law enforcement duties? The Director will...

  14. Is math anxiety in the secondary classroom limiting physics mastery? A study of math anxiety and physics performance

    Science.gov (United States)

    Mercer, Gary J.

    This quantitative study examined the relationship between secondary students with math anxiety and physics performance in an inquiry-based constructivist classroom. The Revised Math Anxiety Rating Scale was used to evaluate math anxiety levels. The results were then compared to the performance on a physics standardized final examination. A simple correlation was performed, followed by a multivariate regression analysis to examine effects based on gender and prior math background. The correlation showed statistical significance between math anxiety and physics performance. The regression analysis showed statistical significance for math anxiety, physics performance, and prior math background, but did not show statistical significance for math anxiety, physics performance, and gender.

  15. Prediction of Mobility Limitations after Hospitalization in Older Medical Patients by Simple Measures of Physical Performance Obtained at Admission to the Emergency Department

    DEFF Research Database (Denmark)

    Bodilsen, Ann Christine; Hedegaard Klausen, Henrik; Petersen, Janne

    2016-01-01

    of four physical performance measures administered at hospital admission to identify older medical patients who manifest mobility limitations 30 days after discharge. Design: Prospective cohort study of patients (≥65 years) admitted to the emergency department for acute medical illness. During the first...... included. Of those, 128 (40%) patients had mobility limitations at follow-up. Univariate analyzes showed that each of the physical performance measures was strongly associated with mobility limitations at follow-up (handgrip strength(women), OR 0.86 (0.81–0.91), handgrip strength(men), OR 0.90 (0...... medical illness, and the Charlson Comorbidity Index. Based on prespecified cut-offs the prognostic accuracy of the four measures for mobility limitation at follow-up was calculated. The sensitivity and specificity were: handgrip strength(women), 56.8 (45.8–67.3), 75.7 (66.8–83.2), handgrip strength...

  16. On performance limitations and property correlations of Al-doped ZnO deposited by radio-frequency sputtering

    Science.gov (United States)

    Crovetto, Andrea; Sand Ottsen, Tobias; Stamate, Eugen; Kjær, Daniel; Schou, Jørgen; Hansen, Ole

    2016-07-01

    The electrical properties of RF-sputtered Al-doped ZnO are often spatially inhomogeneous and strongly dependent on deposition parameters. In this work, we study the mechanisms that limit the minimum resistivity achievable under different deposition regimes. In a low- and intermediate-pressure regime, we find a generalized dependence of the electrical properties, grain size, texture, and Al content on compressive stress, regardless of sputtering pressure or position on the substrate. In a high-pressure regime, a porous microstructure limits the achievable resistivity and causes it to increase over time as well. The primary cause of inhomogeneity in the electrical properties is identified as energetic particle bombardment. Inhomogeneity in oxygen content is also observed, but its effect on the electrical properties is small and limited to the carrier mobility.

  17. On performance limitations and property correlations of Al-doped ZnO deposited by radio-frequency sputtering

    DEFF Research Database (Denmark)

    Crovetto, Andrea; Ottsen, Tobias Sand; Stamate, Eugen

    2016-01-01

    The electrical properties of RF-sputtered Al-doped ZnO are often spatially inhomogeneous and strongly dependent on deposition parameters. In this work, we study the mechanisms that limit the minimum resistivity achievable under different deposition regimes. In a low- and intermediate...

  18. Diagnostic performance of CT colonography with limited cathartic preparation in colorectal cancer screening; comparison with conventional colonoscopy

    Directory of Open Access Journals (Sweden)

    Mohammed Farghally Amin

    2015-09-01

    Conclusion: This study proved that CTC with limited cathartic bowel preparation and iodinated agents for fecal tagging can obtain high sensitivity and PPV values results for <5 mm polyps comparable to those obtained with conventional preparation with laxatives. Furthermore, this method could really improve the acceptance of CTC for colorectal cancer screening.

  19. Modelling, development and optimization of integrated power LDMOS transistor. Performance limits in terms of energy; Modelisation, conception et optimisation de composant de puissance lateral DMOS integre. Etude des limites de performance en energie

    Energy Technology Data Exchange (ETDEWEB)

    Farenc, D.

    1997-12-16

    Technologies for Smart Power Integrated Circuits combine into a single chip Bipolar and CMOS transistors, plus power with lateral or vertical DMOS transistors. Complexity which has been increasing dramatically since the mid-80`s has allowed to integrate, into a single monolithic solution, entire systems. This thesis deals with the modelling, conception and test of the power integrated LDMOS transistor. The power LDMOS transistor is used as a switching device. It is characterized by two parameters which are the Specific On-resistance R{sub sp} and the breakdown voltage BV{sub DSS}. The LDMOS transistor developed for the new Smart Power technology exhibits a Specific On-resistance of 200 m{Omega}{sup *}mm{sup 2} and a breakdown voltage of 60 V. This device is dedicated to automotive applications. A reduction of the power device which is achieved with a low Specific On-resistance puts forward new issues such as the maximum Energy capability. When the power device is switched-off on an inductive load, a certain amount of energy is dissipated; if it is beyond a certain limit, the device is destroyed. Our goal is to determine the energy limits which are associated with our new Power integrated LDMOS transistor. (author) 28 refs.

  20. Monitoring cholinergic activity during attentional performance in mice heterozygous for the choline transporter: a model of cholinergic capacity limits.

    Science.gov (United States)

    Paolone, Giovanna; Mallory, Caitlin S; Koshy Cherian, Ajeesh; Miller, Thomas R; Blakely, Randy D; Sarter, Martin

    2013-12-01

    Reductions in the capacity of the human choline transporter (SLC5A7, CHT) have been hypothesized to diminish cortical cholinergic neurotransmission, leading to risk for cognitive and mood disorders. To determine the acetylcholine (ACh) release capacity of cortical cholinergic projections in a mouse model of cholinergic hypofunction, the CHT+/- mouse, we assessed extracellular ACh levels while mice performed an operant sustained attention task (SAT). We found that whereas SAT-performance-associated increases in extracellular ACh levels of CHT+/- mice were significantly attenuated relative to wildtype littermates, performance on the SAT was normal. Tetrodotoxin-induced blockade of neuronal excitability reduced both dialysate ACh levels and SAT performance similarly in both genotypes. Likewise, lesions of cholinergic neurons abolished SAT performance in both genotypes. However, cholinergic activation remained more vulnerable to the reverse-dialyzed muscarinic antagonist atropine in CHT+/- mice. Additionally, CHT+/- mice displayed greater SAT-disrupting effects of reverse dialysis of the nAChR antagonist mecamylamine. Receptor binding assays revealed a higher density of α4β2* nAChRs in the cortex of CHT+/- mice compared to controls. These findings reveal compensatory mechanisms that, in the context of moderate cognitive challenges, can overcome the performance deficits expected from the significantly reduced ACh capacity of CHT+/- cholinergic terminals. Further analyses of molecular and functional compensations in the CHT+/- model may provide insights into both risk and resiliency factors involved in cognitive and mood disorders.

  1. Association of measured physical performance and demographic and health characteristics with self-reported physical function: implications for the interpretation of self-reported limitations

    Directory of Open Access Journals (Sweden)

    Louie Grant H

    2010-08-01

    Full Text Available Abstract Background Self-reported limitations in physical function often have only weak associations with measured performance on physical tests, suggesting that factors other than performance commonly influence self-reports. We tested if personal or health characteristics influenced self-reported limitations in three tasks, controlling for measured performance on these tasks. Methods We used cross-sectional data on adults aged ≥ 60 years (N = 5396 from the Third National Health and Nutrition Examination Survey to examine the association between the repeated chair rise test and self-reported difficulty rising from a chair. We then tested if personal characteristics, health indicators, body composition, and performance on unrelated tasks were associated with self-reported limitations in this task. We used the same approach to examine associations between personal and health characteristics and self-reported difficulty walking between rooms, controlling for timed 8-foot walk, and self-reported difficulty getting out of bed, controlling for repeated chair rise test results. Results In multivariate analyses, participants who performed worse on the repeated chair rise test were more likely to report difficulty with chair rise. However, older age, lower education level, lower serum albumin, comorbidities, knee pain, and being underweight were also significantly associated with self-reported limitations with chair rise. Results were similar for difficulty walking between rooms and getting out of bed. Conclusions Self-reports of limitations in physical function are influenced by personal and health characteristics that reflect frailty, and should not be interpreted solely as measured difficulty performing the task.

  2. Evaluation of impact limiter performance during end-on and slapdown drop tests of a one-third scale model storage/transport cask system

    Energy Technology Data Exchange (ETDEWEB)

    Yoshimura, H.R.; Bronowski, D.R.; Uncapher, W.L.; Attaway, S.W.; Bateman, V.I.; Carne, T.G.; Gregory, D.L. (Sandia National Labs., Albuquerque, NM (USA)); Huerta, M. (Southwest Engineering Associates, El Paso, TX (USA))

    1990-12-01

    This report describes drop testing of a one-third scale model shipping cask system. Two casks were designed and fabricated by Transnuclear, Inc., to ship spent fuel from the former Nuclear Fuel Services West Valley reprocessing facility in New York to the Idaho National Engineering Laboratory for a long-term spent fuel dry storage demonstration project. As part of the NRC's regulatory certification process, one-third scale model tests were performed to obtain experimental data on impact limiter performance during impact testing. The objectives of the testing program were to (1) obtain deceleration and displacement information for the cask and impact limiter system, (2) obtain dynamic force-displacement data for the impact limiters, (3) verify the integrity of the impact limiter retention system, and (4) examine the crush behavior of the limiters. Two 30-ft (9-m) drop tests were conducted on a mass model of the cask body and scaled balsa and redwood-filled impact limiters. This report describes the results of both tests in terms of measured decelerations, posttest deformation measurements, and the general structural response of the system. 3 refs., 32 figs.

  3. Summary of the half-day internal review of LHC performance limitations (linked to transverse collective effects) during run II (CERN, 29/11/2016)

    CERN Document Server

    Metral, Elias; Biancacci, Nicolo; Buffat, Xavier; Carver, Lee Robert; Iadarola, Giovanni; Li, Kevin Shing Bruce; Persson, Tobias Hakan Bjorn; Romano, Annalisa; Schenk, Michael; Tambasco, Claudia; CERN. Geneva. ATS Department

    2017-01-01

    In this note the half-day internal review of LHC performance limitations (linked to transverse collective effects) during run II (2015-2016), which took place at CERN on 29/11/2016 (https://indico.cern.ch/event/589625/), is summarised and the next steps are discussed.

  4. ‘The engine just started coughing!’ — Limits of physical performance, aging and career continuity in elite endurance sports

    DEFF Research Database (Denmark)

    Ronkainen, Noora; Ryba, Tatiana; Nesti, Mark

    2013-01-01

    This research examines male endurance athletes' experience of aging and/or reaching the perceived limits of physical performance. More specifically, the current study aimed to explore how existential meanings attached to these experiences are connected with athletes' decision-making concerning ca...

  5. On limits of Wireless Communications in a Fading Environment: a General Parameterization Quantifying Performance in Fading Channel

    Directory of Open Access Journals (Sweden)

    Amit Grover

    2014-08-01

    Full Text Available The reliable services along with high throughput can be achieved by using wireless communication systems. These systems also provides a wide coverage because of their features, no doubt MIMO Communication System [1] is one among them. Features provided by these systems ensure the improved system coverage and increased data transmission rate by considering multiple numbers of transmitter and receiver antennas. In this article, the concept of equalization has been considered and finally the performance of the MIMO Systems in Rician flat fading [5] channel is compared with the Rayleigh flat fading channel. It has also been observed that the performance of these Systems in Rician Flat Fading Channel is the best as compare to the Rayleigh Flat Fading Channel [10]. It has been concluded that the successive interference methods provide better performance as compare to others, but their complexity is high. Simulation results shows that ML provides the better performance in comparison to other equalizers but Sphere decoder provides the best performance.

  6. "Acceptance of the Limits of Knowability in Oneself and Others": Performative Politics and Relational Ethics in the Primary School Classroom

    Science.gov (United States)

    Teague, Laura

    2015-01-01

    This paper takes up Judith Butler's calls to suspend the desire to completely know the other, and discusses these in relation to the pedagogic relationship in the classroom. It draws upon existing accounts of performative reinscription as a politics to disrupt exclusionary schooling practices and discusses these alongside Butler's theories of…

  7. Performance limits of high-rate space-to-ground optical communications through the turbulent atmospheric channel

    Science.gov (United States)

    Kaufmann, John E.

    1995-04-01

    Atmospheric turbulence corrupts both the amplitude and phase of an optical field propagating from space to an earth-based receiver. While aperture averaging can mitigate amplitude scintillation effects, the performance of single spatial-mode receiver systems such as coherent detection or preamplified direction detection can be significantly degraded by the corrupted phase when the ratio of aperture diameter D to atmospheric coherence length r0 exceeds unity. Although adaptive optics may be employed to correct the wavefront, in practice the correction is imperfect and the residual phase errors induce a communications performance loss. That loss is quantified here by Monte Carlo simulation techniques. Single-mode-receiver fade statistics for imperfect phase correction are calculated in terms of the atmospheric Greenwood frequency fg, the adaptive optic servo loop cutoff frequency fc, and the ratio D/r0. From these statistics, link bit-error rate (BER) performance is calculated. The results reveal that conventional performance measures such as Strehl ratio or mean signal-to- noise ratio loss can significantly underestimate receiver BER losses. Only when the ratio fg/fc is 0.1 or less will communications losses be small (about 0.5 dB) over a wide range of D/r0.

  8. Beyond Capacity Limitations: Determinants of Word Recall Performance on Verbal Working Memory Span Tasks in Children with SLI

    Science.gov (United States)

    Mainela-Arnold, Elina; Evans, Julia L.

    2005-01-01

    Reduced verbal working memory capacity has been proposed as a possible account of language impairments in specific language impairment (SLI). Studies have shown, however, that differences in strength of linguistic representations in the form of word frequency affect list recall and performance on verbal working memory tasks. This suggests that…

  9. Budget-limited thermal biology: Design, construction and performance of a large, walk-in style temperature-controlled chamber.

    Science.gov (United States)

    Martinez, Eloy; Agosta, Salvatore J

    2016-05-01

    We describe a partial redesign of the conventional air-conditioning system and apply it to the construction of a relatively large (1.87m(3) air mass), walk-in style temperature-controlled chamber (TCC) using parts easily obtained in most countries. We conducted several tests to demonstrate the performance of the TCC. Across the physiologically relevant range of 5-37°C, the TCC took 26.5-50.0min to reach the desired set point temperature. Once at set point, temperature inside the chamber was controlled with an accuracy of ±1.0°C. User-entry effects on deviations from and return times to set point temperature were minimal. Overall, performance of the TCC was sufficient to make precise physiological measurements of insect metabolic rate while controlling assay temperature. Major advantages of the TCC include its simplicity, flexibility, and low cost.

  10. Wideband noise characteristics of a lead-salt diode laser: possibility of quantum noise limited TDLAS performance.

    Science.gov (United States)

    Werle, P; Slemr, F; Gehrtz, M; Bräuchle, C

    1989-05-01

    The wideband noise characteristics of a PbEuSe molecular beam epitaxy diode laser have been measured up to 500 MHz. The cutoff of the frequency dependent (1/f type) laser noise contribution was found to be 170 MHz for this particular laser. Above this cutoff frequency the photon shot noise dominates, as was demonstrated. A noise reduction of more than 2 orders of magnitude was observed in the shot noise limited domain when compared with the 1/f noise dominated region below 1 MHz. This finding indicates that a similar 2 orders of magnitude sensitivity improvement can be achieved in tunable diode laser absorption spectroscopy when frequency modulation techniques are applied instead of the more conventional derivative modulation below 1 MHz.

  11. Phonon scattering limited performance of monolayer MoS{sub 2} and WSe{sub 2} n-MOSFET

    Energy Technology Data Exchange (ETDEWEB)

    Sengupta, Amretashis, E-mail: a.sengupta@vlsi.iiests.ac.in [School of VLSI Technology, Indian Institute of Engineering Science and Technology, Shibpur, Howrah-711103 (India); Chanana, Anuja; Mahapatra, Santanu [Nano-Scale Device Research Laboratory, Department of Electronic Systems Engineering, Indian Institute of Science, Bangalore-560012 (India)

    2015-02-15

    In this paper we show the effect of electron-phonon scattering on the performance of monolayer (1L) MoS{sub 2} and WSe{sub 2} channel based n-MOSFETs. Electronic properties of the channel materials are evaluated using the local density approximation (LDA) in density functional theory (DFT). For phonon dispersion we employ the small displacement / frozen phonon calculations in DFT. Thereafter using the non-equilibrium Green’s function (NEGF) formalism, we study the effect of electron-phonon scattering and the contribution of various phonon modes on the performance of such devices. It is found that the performance of the WSe{sub 2} device is less impacted by phonon scattering, showing a ballisticity of 83% for 1L-WSe{sub 2} FET for channel length of 10 nm. Though 1L-MoS{sub 2} FET of similar dimension shows a lesser ballisticity of 75%. Also in the presence of scattering there exist a a 21–36% increase in the intrinsic delay time (τ) and a 10–18% reduction in peak transconductance (g{sub m}) for WSe{sub 2} and MoS{sub 2} devices respectively.

  12. Performance, Expectation, Interaction and Intimacy: On the Opportunities and Limitations of Arena Stand-up Comedy for Comedians and Audiences

    OpenAIRE

    Lockyer, S

    2015-01-01

    Live stand-up comedy has become increasingly popular over the last few years. A significant trend related to this heightened interest in stand-up comedy is the diversification of stand-up comedy venues. In addition to small rooms in pubs and small/medium-sized designated comedy clubs, stand-up comedy is now often performed in large arenas with audience capacities of 10,000 plus. Through a series of semi-structured interviews with stand-up comedians and stand-up comedy audiences this explorato...

  13. Influence of grain boundary modification on limited performance of wide bandgap Cu(In,Ga)Se2 solar cells

    Science.gov (United States)

    Raghuwanshi, M.; Cadel, E.; Pareige, P.; Duguay, S.; Couzinie-Devy, F.; Arzel, L.; Barreau, N.

    2014-07-01

    The reason why so-called wide-bandgap CuIn1-xGaxSe2 (CIGSe with x > 0.4) based solar cells show hindered performance compared with theoretical expectations is still a matter of debate. In the present Letter, atom probe tomography studies of CuIn1-xGaxSe2 polycrystalline thin films with x varying from 0 to 1 are reported. These investigations confirm that the grain boundaries (GBs) of low gallium containing (x CIGSe layers are Cu-depleted compared with grains interior (GI). In contrast, it is observed that the GBs of widest band gap CIGSe films (x > 0.8) are Cu-enriched compared with GI. For intermediate gallium contents (0.4 < x < 0.8), both types of GBs are detected. This threshold value of 0.4 surprisingly coincides with solar cells output voltage deviation from theoretical expectations, which suggests modifications of GBs properties could participate in the loss of photovoltaic performance.

  14. Influence of grain boundary modification on limited performance of wide bandgap Cu(In,Ga)Se{sub 2} solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Raghuwanshi, M., E-mail: mohit.raghuwanshi@etu.univ-rouen.fr; Cadel, E.; Pareige, P.; Duguay, S. [Groupe de Physique des Materiaux (GPM), UMR 6634 CNRS, Université et INSA de Rouen, Avenue de l' Universite BP 12, 76801 Saint Etienne du Rouvray (France); Couzinie-Devy, F.; Arzel, L.; Barreau, N. [Institut des Materiaux Jean Rouxel (IMN), UMR 6502 CNRS, Université de Nantes, 2 rue de la Houssiniere BP 32229, 44322 Nantes cedex 3 (France)

    2014-07-07

    The reason why so-called wide-bandgap CuIn{sub 1−x}Ga{sub x}Se{sub 2} (CIGSe with x > 0.4) based solar cells show hindered performance compared with theoretical expectations is still a matter of debate. In the present Letter, atom probe tomography studies of CuIn{sub 1−x}Ga{sub x}Se{sub 2} polycrystalline thin films with x varying from 0 to 1 are reported. These investigations confirm that the grain boundaries (GBs) of low gallium containing (x < 0.4) CIGSe layers are Cu-depleted compared with grains interior (GI). In contrast, it is observed that the GBs of widest band gap CIGSe films (x > 0.8) are Cu-enriched compared with GI. For intermediate gallium contents (0.4 < x < 0.8), both types of GBs are detected. This threshold value of 0.4 surprisingly coincides with solar cells output voltage deviation from theoretical expectations, which suggests modifications of GBs properties could participate in the loss of photovoltaic performance.

  15. Endovascular treatment of acute ischemic stroke may be safely performed with no time window limit in appropriately selected patients.

    Science.gov (United States)

    Abou-Chebl, Alex

    2010-09-01

    The traditional time window for acute ischemic stroke intra-arterial therapy (IAT) is stroke duration. Thrombolytics were minimized after 6 hours in favor of mechanical embolectomy or angioplasty+/-stenting. Outcomes (National Institutes of Health Stroke Scale, modified Rankin Scale) were assessed by independent examiners. A multivariate analysis was performed to compare those treated 6 hours (late). Fifty-five patients (mean National Institutes of Health Stroke Scale=19.7+/-5.7) were treated, 34 early and 21 late, with mean time-to-intervention of 3.4+/-1.6 hours and 18.6+/-16.0 hours, respectively. Thrombolysis In Myocardial Ischemia 2 or 3 recanalization was achieved in 82.8% early and 85.7% late patients (P=1.0). Intracerebral hemorrhage occurred in 25.5% overall, but symptomatic intracerebral hemorrhage occurred in 8.8% of the early and 9.5% of the late patients (P=1.0). Thirty-day mortality was similar (29.4% versus 23.8%, P=0.650). At 3 months, 41.2% and 42.9%, respectively, achieved a modified Rankin Scale Stroke Scale was a predictor of modified Rankin Scale acute ischemic stroke can be performed safely regardless of stroke duration. The concept of an acute ischemic stroke treatment window for IAT should be re-evaluated with a clinical trial selecting patients with perfusion mismatch.

  16. The limits of human endurance: what is the greatest endurance performance of all time? Which factors regulate performance at extreme altitude?

    Science.gov (United States)

    Noakes, Timothy David

    2007-01-01

    Humans evolved as an athletic species able to run in the midday heat, to throw with exquisite accuracy and to strike powerfully despite relatively weak upper arms compared to those of the great apes. The true extent to which humans could run long distances was first tested in a unique series of 6-day foot races contested between 1874 and 1888 by professional athletes from England and the United States. These athletes typically would have expended approximately 60,000 kcal (24.12 MJ) of energy during these races. The discovery of the bicycle soon caused the replacement of these races by 6-day cycling races which, in turn, led to the modern day Tour de France, the cycling race across America (RaAM) and two running races across the width of the United States in 1928 and 1929. The total energy expenditures during these different events can be estimated at approximately 168,000, 180,000 and 340,000 kcal respectively. But, in terms of the total energy expenditure, all these performances pale somewhat when compared to that of Robert Falcon Scott's Polar party during the 1911/12 British Antarctic Expedition. For most of 159 consecutive days, Scott's team man-hauled for 10 hours a day to the South Pole and back covering a distance of 2500 km. Their predicted total energy expenditure per individual would have been about 1 million kcal, making theirs, by some margin, the greatest sustained endurance athletic performance of all time. Interestingly, the dogs that provided the pulling power for Norwegian Roald Amundsen's team that was the first to reach the South Pole, 35 days before Scott's party, would have expended about 500,000 kcal in their 97 day trip, making theirs the greatest animal "sporting" performance on record. By contrast, mountain climbers expend only approximately 4000 kcal/day when climbing at extreme altitudes (above 4000 m). This relatively low rate of energy expenditure results from the low exercise intensities that can be sustained at extreme altitude. Here

  17. Performance and limits of KNN-based positioning methods for GSM networks over leaky feeder in underground tunnels

    CERN Document Server

    Pereira, Fernando; Moreira, Adriano; Ricardo, Manuel

    2012-01-01

    Localisation techniques have long been of major importance for safety systems and a lot of research has been conducted in the distributed computing field regarding its functionality and reliability. In the specific scenario of long yet narrow tunnels existing at CERN, localisation methods will enable a number of applications and processes to substantially reduce human intervention. In this article, we evaluate the use of fingerprinting techniques with GSM signal available throughout the LHC tunnel via a radiating cable and compare some methods to estimate the location. In the tests, 16 variants of the K-Nearest Neighbour algorithm, employing different distance weighting methods and fingerprint grouping functions, are taken into consideration and their performance is assessed with a specific rating algorithm. The existing GSM infrastructure and tunnel conditions seem to be favourable to the adoption of these fingerprinting methods. Nevertheless, significant variations in the signal have been observed which mig...

  18. An improved low-voltage ride-through performance of DFIG based wind plant using stator dynamic composite fault current limiter.

    Science.gov (United States)

    Gayen, P K; Chatterjee, D; Goswami, S K

    2016-05-01

    In this paper, an enhanced low-voltage ride-through (LVRT) performance of a grid connected doubly fed induction generator (DFIG) has been presented with the usage of stator dynamic composite fault current limiter (SDCFCL). This protection circuit comprises of a suitable series resistor-inductor combination and parallel bidirectional semiconductor switch. The SDCFCL facilitates double benefits such as reduction of rotor induced open circuit voltage due to increased value of stator total inductance and concurrent increase of rotor impedance. Both effects will limit rotor circuit over current and over voltage situation more secured way in comparison to the conventional scheme like the dynamic rotor current limiter (RCL) during any type of fault situation. The proposed concept is validated through the simulation study of the grid integrated 2.0MW DFIG.

  19. Self-regulatory strength depletion and muscle-endurance performance: a test of the limited-strength model in older adults.

    Science.gov (United States)

    Bray, Steven R; Martin Ginis, Kathleen A; Woodgate, Jennifer

    2011-07-01

    Self-regulation consumes a form of strength or energy. The authors investigated aftereffects of self-regulation depletion on muscle-endurance performance in older adults. Participants (N = 61, mean age = 71) were randomized to a self-regulation-depletion or control group and completed 2 muscle-endurance performance tasks involving isometric handgrip squeezing that were separated by a cognitive-depletion task. The depletion group showed greater deterioration of muscle-endurance performance than controls, F(1, 59) = 7.31, p = .009. Results are comparable to those of younger adults in a similar study and support Baumeister et al.'s limited-strength model. Self-regulation may contribute to central-nervous-system fatigue; however, biological processes may allow aging muscle to offset depletion of self-regulatory resources affecting muscle-endurance performance.

  20. The dynamic limits of hop height: Biological actuator capabilities and mechanical requirements of task produce incongruity between one- and two-legged performance.

    Science.gov (United States)

    Gutmann, Anne K; Bertram, John Ea

    2016-03-01

    The maximum hop height attainable for a given hop frequency falls well below the theoretical limit dictated by gravity, h = g/8f(2). However, maximum hop height is proportional to 1/f(2), suggesting that ground reaction force and, hence, force production capabilities of the leg muscles limit human hopping performance. Curiously, during one-legged hopping, subjects were able to produce substantially more than 50% the ground reaction force produced during two-legged maximum height hopping-66% on average and as much as 90% the total force produced during two-legged hopping. This implies that two legs together should be able to produce an average of 1.32 times and as much as 1.8 times the force actually measured during two-legged maximum height hopping. Why were our subjects unable to access this extra force capacity when hopping on two legs? Here, we show that this apparent bilateral deficit and other features of maximum height hopping can be explained by the interaction of the mechanical requirements of hopping with the force-velocity and force-length relationships that dictate the force production capacity of the leg muscles. Identifying the factors that limit performance in hopping provides an opportunity to understand how functional limits are determined in more complex activities such as running and jumping.

  1. Power Control and Performance Analysis of Outage-Limited Cellular Network with MUD-SIC and Macro-Diversity

    CERN Document Server

    Ng, Derrick Wing Kwan

    2010-01-01

    In this paper, we analyze the uplink goodput (bits/sec/Hz successfully decoded) and per-user packet outage in a cellular network using multi-user detection with successive interference cancellation (MUD-SIC). We consider non-ergodic fading channels where microscopic fading channel information is not available at the transmitters. As a result, packet outage occurs whenever the data rate of packet transmissions exceeds the instantaneous mutual information even if powerful channel coding is applied for protection. We are interested to study the role of macro-diversity (MDiv) between multiple base stations on the MUD-SIC performance where the effect of potential error-propagation during the SIC processing is taken into account. While the jointly optimal power and decoding order in the MUD-SIC are NP hard problem, we derive a simple on/off power control and asymptotically optimal decoding order with respect to the transmit power. Based on the information theoretical framework, we derive the closed-form expressions...

  2. Growth performance, health and behavioural characteristics of Brown Swiss calves fed a limited amount of acidified whole milk

    Directory of Open Access Journals (Sweden)

    Jale Metin

    2010-01-01

    Full Text Available The purpose of this study was to compare performances of 27 Brown Swiss calves (13 male, 14 female fed acidified whole milk (AM or sweet whole milk (SM at 8% of birth weight during 35 days. Daily body weight gains of calves that consumed AM were similar to those for calves fed SM. Overall feed efficiency ratio of AM-fed calves was also similar to those of SM-fed calves. Calf faecal consistency score and percent days with scours (P<0.01 of calves that consumed AM were significantly lower than those offered SM. Some of the behavioural traits such as frequency of daily meals of milk and total time spent consuming milk of calves consuming AM were significantly (P<0.05 higher than those of calves fed SM. On the other hand, number of days that assistance was needed to drink milk from open pail for AM-fed calves was higher (P<0.01 than that of calves that consumed SM. The results obtained in this study suggested that feeding AM decreased incidence of scours in young Brown Swiss calves without decreasing growth and feed efficiency.

  3. Fatigue as a long-term risk factor for limitations in instrumental activities of daily living and/or mobility performance in older adults after 10 years

    Science.gov (United States)

    Mueller-Schotte, Sigrid; Bleijenberg, Nienke; van der Schouw, Yvonne T; Schuurmans, Marieke J

    2016-01-01

    Objectives Decline in the performance of instrumental activities of daily living (IADL) and mobility may be preceded by symptoms the patient experiences, such as fatigue. The aim of this study is to investigate whether self-reported non-task-specific fatigue is a long-term risk factor for IADL-limitations and/or mobility performance in older adults after 10 years. Methods A prospective study from two previously conducted cross-sectional studies with 10-year follow-up was conducted among 285 males and 249 females aged 40–79 years at baseline. Fatigue was measured by asking “Did you feel tired within the past 4 weeks?” (males) and “Do you feel tired?” (females). Self-reported IADLs were assessed at baseline and follow-up. Mobility was assessed by the 6-minute walk test. Gender-specific associations between fatigue and IADL-limitations and mobility were estimated by multivariable logistic and linear regression models. Results A total of 18.6% of males and 28.1% of females were fatigued. After adjustment, the odds ratio for fatigued versus non-fatigued males affected by IADL-limitations was 3.3 (P=0.023). In females, the association was weaker and not statistically significant, with odds ratio being 1.7 (P=0.154). Fatigued males walked 39.1 m shorter distance than those non-fatigued (P=0.048). For fatigued females, the distance was 17.5 m shorter compared to those non-fatigued (P=0.479). Conclusion Our data suggest that self-reported fatigue may be a long-term risk factor for IADL-limitations and mobility performance in middle-aged and elderly males but possibly not in females. PMID:27877027

  4. Corrida em piscina funda: limites e possibilidades para o alto desempenho Velocidad en piscina de profundidad: límites y posibilidades para un alto desempeño Deep water running: limits and possibilities for high performance

    Directory of Open Access Journals (Sweden)

    Leonardo Alexandre Peyré-Tartaruga

    2006-10-01

    Full Text Available O objetivo deste estudo foi analisar os limites e possibilidades da utilização da corrida em piscina funda no treinamento de corredores de rendimento. Além disso, são discutidas as respostas agudas submáximas, máximas e crônicas, do ponto de vista fisiológico e biomecânico entre a corrida em terra e em piscina funda. As respostas máximas de freqüência cardíaca e consumo de oxigênio são menores no exercício aquático do que na corrida terrestre. Dados experimentais sugerem o uso do treinamento de corrida em piscina funda para corredores de rendimento; contudo, essas evidências são limitadas para treinamentos de até 10 semanas.El objetivo de este estudio ha sido el de analizar los límites y posibilidades de la utilización de carreras de velocidad en piscina de profundidad durante el entrenamiento de velocista de rendimiento. Además de esto, son discutidas las respuestas agudas submáximas, máximas y crónicas, bajo el punto de vista fisiológico y biomecánico entre la carrera en tierra y en piscina profunda. Las respuestas máximas de frecuencia cardíaca y consumo de oxígeno son menores en el ejercicio acuático que en la de tierra. Datos experimentales sugieren el uso de entrenamiento de carrera en piscina profunda para velocistas de rendimiento, sin embargo estas evidencias son limitadas a entrenamientos de hasta 10 semanas.The purpose of this study was to analyze the limits and possibilities of deep water running on training of performance runners. Besides, it has been discussed the submaximal acute, maximal acute and chronical responses, following physiological and biomechanical aspects between running on land and deep water running. Heart rate and oxygen uptake's maximal responses are lower in aquatic exercise than in running on land. Experimental evidences suggest the deep water running training for performance athletes, but these studies are limited in training program until ten weeks.

  5. Resonant excitation of precursor molecules in improving the particle crystallinity, growth rate and optical limiting performance of carbon nano-onions

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Y; Zhou, Y S; Park, J B; Wang, H; He, X N; Lu, Y F [Department of Electrical Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0511 (United States); Luo, H F; Jiang, L, E-mail: ylu2@unl.edu [Department of Mechanical and Automation Engineering, Beijing Institute of Technology, Beijing 10008 (China)

    2011-04-22

    A catalyst-free and highly efficient synthetic method for growing carbon nano-onions (CNOs) in open air has been developed through the laser resonant excitation of a precursor molecule, ethylene, in a combustion process. Highly concentric CNO particles with improved crystallinity were obtained at a laser wavelength of 10.532 {mu}m through the resonant excitation of the CH{sub 2} wagging mode of the ethylene molecules. A higher growth rate up to 2.1 g h{sup -1} was obtained, compared with that without a laser (1.3 g h{sup -1}). Formation of the CNOs with ordered graphitic shells is ascribed to the decomposition of polycyclic aromatic hydrocarbons (PAHs) into C{sub 2} species. The optical limiting performances of the CNOs grown by the combustion processes were investigated. CNOs grown at 10.532 {mu}m laser excitation demonstrated improved optical limiting properties due to the improved crystallinity.

  6. Evaluation of limiting factors affecting photovoltaic performance of low-temperature-processed TiO₂ films in dye-sensitized solar cells.

    Science.gov (United States)

    Lee, Taek-Yong; Kim, Hui-Seon; Park, Nam-Gyu

    2014-04-14

    Limiting factors affecting photovoltaic performance of dye-sensitized solar cell employing low-temperature-processed TiO2 films were investigated. TiO2 films were prepared at a low temperature of 200 °C using the normal alcohol-containing binder-free TiO2 paste (LT200). Their photovoltaic performance was compared to a high-temperature (550 °C) annealed TiO2 film prepared using a polymer binder containing TiO2 paste (HT550). Compared to the proportional increase in conversion efficiency with TiO2 film thickness upto 14 μm for HT550, the increase in efficiency was terminated at relatively smaller thickness of about 8 μm for LT200 mainly due to unaugmented photocurrent. From the transient photocurrent-voltage studies, the electron transport rate was found to be almost identical, while charge recombination was one order of magnitude faster for LT200. Consequently, the electron diffusion length was more than 2-3 times shorter for LT200 than for HT550. Electron diffusion length and electron life time obtained from electrochemical impedance analysis were well consistent with those observed from transient measurement. Density of states (DOS) was evaluated to be shallow and narrow in LT200, which was responsible for limiting photovoltaic performance in the low-temperature processed TiO2 film.

  7. Knock-Limited Performance of Triptane and 28-R Fuel Blends as Affected by Changes in Compression Ratio and in Engine Operating Variables

    Science.gov (United States)

    Brun, Rinaldo J.; Feder, Melvin S.; Fisher, William F.

    1947-01-01

    A knock-limited performance investigation was conducted on blends of triptane and 28-P fuel with a 12-cylinder, V-type, liquid-cooled aircraft engine of 1710-cubic-inch displacement at three compression ratios: 6.65, 7.93, and 9.68. At each compression ratio, the effect of changes in temperature of the inlet air to the auxiliary-stage supercharger and in fuel-air ratio were investigated at engine speeds of 2280 and. 3000 rpm. The results show that knock-limited engine performance, as improved by the use of triptane, allowed operation at both take-off and cruising power at a compression ratio of 9.68. At an inlet-air temperature of 60 deg F, an engine speed of 3000 rpm ; and a fuel-air ratio of 0,095 (approximately take-off conditions), a knock-limited engine output of 1500 brake horsepower was possible with 100-percent 28-R fuel at a compression ratio of 6.65; 20-percent triptane was required for the same power output at a compression ratio of 7.93, and 75 percent at a compression ratio of 9.68 allowed an output of 1480 brake horsepower. Knock-limited power output was more sensitive to changes in fuel-air ratio as the engine speed was increased from 2280 to 3000 rpm, as the compression ratio is raised from 6.65 to 9.68, or as the inlet-air temperature is raised from 0 deg to 120 deg F.

  8. The occurrence of core muscle fatigue during high-intensity running exercise and its limitation to performance: the role of respiratory work.

    Science.gov (United States)

    Tong, Tomas K; Wu, Shing; Nie, Jinlei; Baker, Julien S; Lin, Hua

    2014-05-01

    This study investigated the occurrence of core muscle fatigue during high-intensity running exercise and its limitation to exercise performance. A secondary aim was to investigate whether respiratory muscle work performed during intense running periods, would contribute to core muscle fatigue. Nine male recreational runners were recruited for two reasons; (1) to perform a continuous treadmill run at 85% VO2max with and without core muscle fatigue in the CR_F and CR trials, respectively; and (2) to mimic the treadmill run-induced respiratory response recorded in the CR trial while subjects were free of whole-body exercise (Mimic trial). The changes in global core muscle function with fatigue in this study were evaluated by performing a sport-specific endurance plank test (SEPT), and the associated influence on running performance was examined by comparing the time to exhaustion during the treadmill run between the CR and CR_F trials. Subsequent to the treadmill run in the CR trial, SEPT (255.7 ± 85.3 vs 177.3 ± 80.6 s) was reduced from baseline in all runners. The reduction correlated (r = 0.67) with the concomitant decline in inspiratory muscle function revealed by maximal inspiratory mouth pressure (PImax: 151.3 ± 18.2 vs 133.3 ± 17.2 cmH2O, p core muscle workout in the CR_F trial, the running capacity was impaired significantly (10.7 ± 4.5 vs 6.5 ± 2.0 min, p core muscle fatigue in runners. The core muscle fatigue, which may be partly attributed to the corresponding respiratory work, may limit their running endurance. Inspiratory muscle function appears to be essential for core stabilization during the intense running. Key pointsA high-intensity maximum run may induce core muscle fatigue in runners. The core muscle fatigue, which may be partly attributed to the corresponding respiratory work, may limit their running endurance.In support of previous notion, inspiratory muscles may share the work of core stabilization during intense exercise, while

  9. The influence of high-octane fuel blends on the performance of a two-stroke SI engine with knock-limited-compression ratio

    Science.gov (United States)

    Poola, Ramesh B.; Bhasker, T.; Nagalingam, B.; Gopalakrishnan, K. V.

    The use of alcohol-gasoline blends enables the favorable features of alcohols to be utilized in spark ignition (SI) engines while avoiding the shortcomings of their application as straight fuels. Eucalyptus and orange oils possess high octane values and are also good potential alternative fuels for SI engines. The high octane value of these fuels can enhance the octane value of the fuel when it is blended with low-octane gasoline. In the present work, 20 percent by volume of orange oil, eucalyptus oil, methanol and ethanol were blended separately with gasoline, and the performance, combustion and exhaust emission characteristics were evaluated at two different compression ratios. The phase separation problems arising from the alcohol-gasoline blends were minimized by adding eucalyptus oil as a cosolvent. Test results indicate that the compression ratio can be raised from 7.4 to 9 without any detrimental effect, due to the higher octane rating of the fuel blends. Knock-limited maximum brake output also increases due to extension of the knock limit. The knock limit is extended by methanol-eucalyptus-ethanol-orange oil blends, in descending order.

  10. Fatigue as a long-term risk factor for limitations in instrumental activities of daily living and/or mobility performance in older adults after 10 years

    Directory of Open Access Journals (Sweden)

    Mueller-Schotte S

    2016-11-01

    Full Text Available Sigrid Mueller-Schotte,1–3 Nienke Bleijenberg,1,2,4 Yvonne T van der Schouw,1 Marieke J Schuurmans2,4 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands; 2Department for the Chronically Ill, University of Applied Sciences Utrecht, the Netherlands; 3Department of Optometry and Orthoptics, University of Applied Sciences Utrecht, the Netherlands; 4Department of Rehabilitation, Nursing Science and Sports, University Medical Center Utrecht, the Netherlands Objectives: Decline in the performance of instrumental activities of daily living (IADL and mobility may be preceded by symptoms the patient experiences, such as fatigue. The aim of this study is to investigate whether self-reported non-task-specific fatigue is a long-term risk factor for IADL-limitations and/or mobility performance in older adults after 10 years. Methods: A prospective study from two previously conducted cross-sectional studies with 10-year follow-up was conducted among 285 males and 249 females aged 40–79 years at baseline. Fatigue was measured by asking “Did you feel tired within the past 4 weeks?” (males and “Do you feel tired?” (females. Self-reported IADLs were assessed at baseline and follow-up. Mobility was assessed by the 6-minute walk test. Gender-specific associations between fatigue and IADL-limitations and mobility were estimated by multivariable logistic and linear regression models. Results: A total of 18.6% of males and 28.1% of females were fatigued. After adjustment, the odds ratio for fatigued versus non-fatigued males affected by IADL-limitations was 3.3 (P=0.023. In females, the association was weaker and not statistically significant, with odds ratio being 1.7 (P=0.154. Fatigued males walked 39.1 m shorter distance than those non-fatigued (P=0.048. For fatigued females, the distance was 17.5 m shorter compared to those non-fatigued (P=0.479. Conclusion: Our data suggest that self-reported fatigue

  11. Functioning Without Cartilage: Older People With Radiographic Knee Osteoarthritis Who Self-Report No Functional Limitations Do Score Lower on a Performance Battery.

    Science.gov (United States)

    van Leeuwen, Daniël M; van de Bunt, Fabian; de Ruiter, Cornelis J; van Schoor, Natasja M; Deeg, Dorly J H; Emanuel, Kaj S

    2017-09-18

    The majority of the older population shows signs of radiographic knee osteoarthritis. However, many remain without functional complaints for a long period. This study aims to find early functional changes associated with stages of radiographic knee osteoarthritis. A group of older people without self-reported complaints was divided in two groups: knee osteoarthritis (K&L = 2-4, N = 29) and control (K&L = 0-1, N = 31). Muscle function was assessed with voluntary and electrically-stimulated isometric knee contractions, including a fatigue test. Physical functioning was assessed with a 6-min walk test (6MWT), a stair climb test (SCT), and a short performance battery. There were no differences in muscle function parameters, 6MWT, and SCT between groups. A clinically relevant lower score on the performance battery was found in participants with knee osteoarthritis. In conclusion, even when older people indicate to have no functional limitations, a decline in functional outcome can be measured with a physical performance battery.

  12. Limitations of experiments performed in artificially made OECD standard soils for predicting cadmium, lead and zinc toxicity towards organisms living in natural soils

    DEFF Research Database (Denmark)

    Sydow, Mateusz; Chrzanowski, Lukasz; Cedergreen, Nina

    2017-01-01

    Development of comparative toxicity potentials of cationic metals in soils for applications in hazard ranking and toxic impact assessment is currently jeopardized by the availability of experimental effect data. To compensate for this deficiency, data retrieved from experiments carried out...... in standardized artificial soils, like OECD soils, could potentially be tapped as a source of effect data. It is, however, unknown whether such data are applicable to natural soils where the variability in pore water concentrations of dissolved base cations is large, and where mass transfer limitations of metal...... uptake can occur. Here, free ion activity models (FIAM) and empirical regression models (ERM, with pH as a predictor) were derived from total metal EC50 values (concentration with effects in 50% of individuals) using speciation for experiments performed in artificial OECD soils measuring ecotoxicological...

  13. Fuel and Core Design Options to Overcome the Heavy Metal Loading Limit and Improve Performance and Safety of Liquid Salt Cooled Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Petrovic, Bojan [Georgia Inst. of Technology, Atlanta, GA (United States); Maldonado, Ivan [Univ. of Tennessee, Knoxville, TN (United States)

    2016-04-14

    The research performed in this project addressed the issue of low heavy metal loading and the resulting reduced cycle length with increased refueling frequency, inherent to all FHR designs with solid, non-movable fuel based on TRISO particles. Studies performed here focused on AHTR type of reactor design with plate (“plank”) fuel. Proposal to FY12 NEUP entitled “Fuel and Core Design Options to Overcome the Heavy Metal Loading Limit and Improve Performance and Safety of Liquid Salt Cooled Reactors” was selected for award, and the 3-year project started in August 2012. A 4-month NCE was granted and the project completed on December 31, 2015. The project was performed by Georgia Tech (Prof. Bojan Petrovic, PI) and University of Tennessee (Prof. Ivan Maldonado, Co-PI), with a total funding of $758,000 over 3 years. In addition to two Co-PIs, the project directly engaged 6 graduate students (at doctoral or MS level) and 2 postdoctoral researchers. Additionally, through senior design projects and graduate advanced design projects, another 23 undergraduate and 12 graduate students were exposed to and trained in the salt reactor technology. We see this as one of the important indicators of the project’s success and effectiveness. In the process, 1 journal article was published (with 3 journal articles in preparation), together with 8 peer-reviewed full conference papers, 8 peer-reviewed extended abstracts, as well as 1 doctoral dissertation and 2 master theses. The work included both development of models and methodologies needed to adequately analyze this type of reactor, fuel, and its fuel cycle, as well as extensive analyses and optimization of the fuel and core design.

  14. Performance limitations in thieno[3,4-c]pyrrole-4,6-dione-based polymer:ITIC solar cells

    KAUST Repository

    Yang, Fan

    2017-08-15

    We report a systematic study of the efficiency limitations of non-fullerene organic solar cells that exhibit a small energy loss (Eloss) between the polymer donor and the non-fullerene acceptor. To clarify the impact of Eloss on the performance of the solar cells, three thieno[3,4-c]pyrrole-4,6-dione-based conjugated polymers (PTPD3T, PTPD2T, and PTPDBDT) are employed as the electron donor, which all have complementary absorption spectra compared with the ITIC acceptor. The corresponding photovoltaic devices show that low Eloss (0.54 eV) in PTPDBDT:ITIC leads to a high open-circuit voltage (Voc) of 1.05 V, but also to a small quantum efficiency, and in turn photocurrent. The high Voc or small energy loss in the PTPDBDT-based solar cells is a consequence of less non-radiative recombination, whereas the low quantum efficiency is attributed to the unfavorable micro-phase separation, as confirmed by the steady-state and time-resolved photoluminescence experiments, grazing-incidence wide-angle X-ray scattering, and resonant soft X-ray scattering (R-SoXS) measurements. We conclude that to achieve high performance non-fullerene solar cells, it is essential to realize a large Voc with small Eloss while simultaneously maintaining a high quantum efficiency by manipulating the molecular interaction in the bulk-heterojunction.

  15. Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry.

    Science.gov (United States)

    Song, Hongjian; Olsen, Ole H; Persson, Egon; Rand, Kasper D

    2014-12-19

    Factor VIIa (FVIIa) is a trypsin-like protease that plays an important role in initiating blood coagulation. Very limited structural information is available for the free, inactive form of FVIIa that circulates in the blood prior to vascular injury and the molecular details of its activity enhancement remain elusive. Here we have applied hydrogen/deuterium exchange mass spectrometry coupled to electron transfer dissociation to pinpoint individual residues in the heavy chain of FVIIa whose conformation and/or local interaction pattern changes when the enzyme transitions to the active form, as induced either by its cofactor tissue factor or a covalent active site inhibitor. Identified regulatory residues are situated at key sites across one continuous surface of the protease domain spanning the TF-binding helix across the activation pocket to the calcium binding site and are embedded in elements of secondary structure and at the base of flexible loops. Thus these residues are optimally positioned to mediate crosstalk between functional sites in FVIIa, particularly the cofactor binding site and the active site. Our results unambiguously show that the conformational allosteric activation signal extends to the EGF1 domain in the light chain of FVIIa, underscoring a remarkable intra- and interdomain allosteric regulation of this trypsin-like protease. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  16. Knock-Limited Performance of Triptane and Xylidines Blended with 28-R Aviation Fuel at High Compression Ratios and Maximum-Economy Spark Setting

    Science.gov (United States)

    Held, Louis F.; Pritchard, Ernest I.

    1946-01-01

    An investigation was conducted to evaluate the possibilities of utilizing the high-performance characteristics of triptane and xylidines blended with 28-R fuel in order to increase fuel economy by the use of high compression ratios and maximum-economy spark setting. Full-scale single-cylinder knock tests were run with 20 deg B.T.C. and maximum-economy spark settings at compression ratios of 6.9, 8.0, and 10.0, and with two inlet-air temperatures. The fuels tested consisted of triptane, four triptane and one xylidines blend with 28-R, and 28-R fuel alone. Indicated specific fuel consumption at lean mixtures was decreased approximately 17 percent at a compression ratio of 10.0 and maximum-economy spark setting, as compared to that obtained with a compression ratio of 6.9 and normal spark setting. When compression ratio was increased from 6.9 to 10.0 at an inlet-air temperature of 150 F, normal spark setting, and a fuel-air ratio of 0.065, 55-percent triptane was required with 28-R fuel to maintain the knock-limited brake power level obtained with 28-R fuel at a compression ratio of 6.9. Brake specific fuel consumption was decreased 17.5 percent at a compression ratio of 10.0 relative to that obtained at a compression ratio of 6.9. Approximately similar results were noted at an inlet-air temperature of 250 F. For concentrations up through at least 20 percent, triptane can be more efficiently used at normal than at maximum-economy spark setting to maintain a constant knock-limited power output over the range of compression ratios tested.

  17. Insights into the Performance Limits of the Li7P3S11 Superionic Conductor: A Combined First-Principles and Experimental Study.

    Science.gov (United States)

    Chu, Iek-Heng; Nguyen, Han; Hy, Sunny; Lin, Yuh-Chieh; Wang, Zhenbin; Xu, Zihan; Deng, Zhi; Meng, Ying Shirley; Ong, Shyue Ping

    2016-03-01

    The Li7P3S11 glass-ceramic is a promising superionic conductor electrolyte (SCE) with an extremely high Li(+) conductivity that exceeds that of even traditional organic electrolytes. In this work, we present a combined computational and experimental investigation of the material performance limitations in terms of its phase and electrochemical stability, and Li(+) conductivity. We find that Li7P3S11 is metastable at 0 K but becomes stable at above 630 K (∼360 °C) when vibrational entropy contributions are accounted for, in agreement with differential scanning calorimetry measurements. Both scanning electron microscopy and the calculated Wulff shape show that Li7P3S11 tends to form relatively isotropic crystals. In terms of electrochemical stability, first-principles calculations predict that, unlike the LiCoO2 cathode, the olivine LiFePO4 and spinel LiMn2O4 cathodes are likely to form stable passivation interfaces with the Li7P3S11 SCE. This finding underscores the importance of considering multicomponent integration in developing an all-solid-state architecture. To probe the fundamental limit of its bulk Li(+) conductivity, a comparison of conventional cold-press sintered versus spark-plasma sintering (SPS) Li7P3S11 was done in conjunction with ab initio molecular dynamics (AIMD) simulations. Though the measured diffusion activation barriers are in excellent agreement, the AIMD-predicted room-temperature Li(+) conductivity of 57 mS cm(-1) is much higher than the experimental values. The optimized SPS sample exhibits a room-temperature Li(+) conductivity of 11.6 mS cm(-1), significantly higher than that of the cold-pressed sample (1.3 mS cm(-1)) due to the reduction of grain boundary resistance by densification. We conclude that grain boundary conductivity is limiting the overall Li(+) conductivity in Li7P3S11, and further optimization of overall conductivities should be possible. Finally, we show that Li(+) motions in this material are highly collective, and

  18. Performance of a limiting-antigen avidity enzyme immunoassay for cross-sectional estimation of HIV incidence in the United States.

    Directory of Open Access Journals (Sweden)

    Jacob Konikoff

    Full Text Available A limiting antigen avidity enzyme immunoassay (HIV-1 LAg-Avidity assay was recently developed for cross-sectional HIV incidence estimation. We evaluated the performance of the LAg-Avidity assay alone and in multi-assay algorithms (MAAs that included other biomarkers.Performance of testing algorithms was evaluated using 2,282 samples from individuals in the United States collected 1 month to >8 years after HIV seroconversion. The capacity of selected testing algorithms to accurately estimate incidence was evaluated in three longitudinal cohorts. When used in a single-assay format, the LAg-Avidity assay classified some individuals infected >5 years as assay positive and failed to provide reliable incidence estimates in cohorts that included individuals with long-term infections. We evaluated >500,000 testing algorithms, that included the LAg-Avidity assay alone and MAAs with other biomarkers (BED capture immunoassay [BED-CEIA], BioRad-Avidity assay, HIV viral load, CD4 cell count, varying the assays and assay cutoffs. We identified an optimized 2-assay MAA that included the LAg-Avidity and BioRad-Avidity assays, and an optimized 4-assay MAA that included those assays, as well as HIV viral load and CD4 cell count. The two optimized MAAs classified all 845 samples from individuals infected >5 years as MAA negative and estimated incidence within a year of sample collection. These two MAAs produced incidence estimates that were consistent with those from longitudinal follow-up of cohorts. A comparison of the laboratory assay costs of the MAAs was also performed, and we found that the costs associated with the optimal two assay MAA were substantially less than with the four assay MAA.The LAg-Avidity assay did not perform well in a single-assay format, regardless of the assay cutoff. MAAs that include the LAg-Avidity and BioRad-Avidity assays, with or without viral load and CD4 cell count, provide accurate incidence estimates.

  19. Coordinated Control of Superconducting Fault Current Limiter and Superconducting Magnetic Energy Storage for Transient Performance Enhancement of Grid-Connected Photovoltaic Generation System

    Directory of Open Access Journals (Sweden)

    Lei Chen

    2017-01-01

    Full Text Available In regard to the rapid development of renewable energy sources, more and more photovoltaic (PV generation systems have been connected to main power networks, and it is critical to enhance their transient performance under short-circuit faults conditions. This paper proposes and studies the coordinated control of a flux-coupling-type superconducting fault current limiter (SFCL and a superconducting magnetic energy storage (SMES, to improve the fault ride through (FRT capability and smooth the power fluctuation of a grid-connected PV generation system. Theoretical analyses of the device structure, operating principle and control strategy are conducted, and a detailed simulation model of 100 kW class PV generation system is built in MATLAB/SIMULINK. During the simulations of the symmetrical and asymmetrical faults, the maximum power point tracking (MPPT control is disabled, and four different cases including without auxiliary, with SFCL, with SMES, and with SFCL-SMES, are compared. From the demonstrated results, the combination of without MPPT and with SFCL-SMES can more efficiently improve the point of common coupling (PCC voltage sag, inhibit the DC-link overvoltage and alleviate the power fluctuation. Finally, a preliminary parameter optimization method is suggested for the SFCL and the SMES, and it is helpful to promote their future application in the real PV projects.

  20. Computer controlled performance mapping of thermionic converters: effect of collector, guard-ring potential imbalances on the observed collector current-density, voltage characteristics and limited range performance map of an etched-rhenium, niobium planar converter

    Science.gov (United States)

    Manista, E. J.

    1972-01-01

    The effect of collector, guard-ring potential imbalance on the observed collector-current-density J, collector-to-emitter voltage V characteristic was evaluated in a planar, fixed-space, guard-ringed thermionic converter. The J,V characteristic was swept in a period of 15 msec by a variable load. A computerized data acquisition system recorded test parameters. The results indicate minimal distortion of the J,V curve in the power output quadrant for the nominal guard-ring circuit configuration. Considerable distortion, along with a lowering of the ignited-mode striking voltage, was observed for the configuration with the emitter shorted to the guard ring. A limited-range performance map of an etched-rhenium, niobium, planar converter was obtained by using an improved computer program for the data acquisition system.

  1. Current limiters

    Energy Technology Data Exchange (ETDEWEB)

    Loescher, D.H. [Sandia National Labs., Albuquerque, NM (United States). Systems Surety Assessment Dept.; Noren, K. [Univ. of Idaho, Moscow, ID (United States). Dept. of Electrical Engineering

    1996-09-01

    The current that flows between the electrical test equipment and the nuclear explosive must be limited to safe levels during electrical tests conducted on nuclear explosives at the DOE Pantex facility. The safest way to limit the current is to use batteries that can provide only acceptably low current into a short circuit; unfortunately this is not always possible. When it is not possible, current limiters, along with other design features, are used to limit the current. Three types of current limiters, the fuse blower, the resistor limiter, and the MOSFET-pass-transistor limiters, are used extensively in Pantex test equipment. Detailed failure mode and effects analyses were conducted on these limiters. Two other types of limiters were also analyzed. It was found that there is no best type of limiter that should be used in all applications. The fuse blower has advantages when many circuits must be monitored, a low insertion voltage drop is important, and size and weight must be kept low. However, this limiter has many failure modes that can lead to the loss of over current protection. The resistor limiter is simple and inexpensive, but is normally usable only on circuits for which the nominal current is less than a few tens of milliamperes. The MOSFET limiter can be used on high current circuits, but it has a number of single point failure modes that can lead to a loss of protective action. Because bad component placement or poor wire routing can defeat any limiter, placement and routing must be designed carefully and documented thoroughly.

  2. Effect of Phytase Superdoses and Citric Acid on Growth Performance, Plasma Phosphorus and Tibia Ash in Broilers Fed Canola Meal-Based Diets Severely Limited in Available Phosphorus

    Directory of Open Access Journals (Sweden)

    Taheri HR

    2015-06-01

    Full Text Available This experiment was conducted to investigate the effect of phytase superdoses alone or in combination with citric acid (CA in canola meal-based diets severely limited in available phosphorus (Pa on growth performance, plasma phosphorus (P, and tibia ash (TA in broilers from 22 to 42 d of age. Two hundreds and eighty 21-d-old male broilers were used in 28 pens of 10 birds per each. The experimental diets consisted of a positive control (PC diet and six negative control (NC diets which consisted of two levels of CA (0 and 20 g/Kg and three levels of phytase (0, 1000 and 4000 U/Kg in a 2 × 3 factorial arrangement. The PC diet contained 4.3 g/Kg Pa, but all NC diets contained 1.5 g/Kg Pa. Results indicated that the birds fed the PC diet had a significantly higher average daily gain (ADG, plasma P and TA, but a lower feed conversion ratio (FCR than those fed the NC diet. The ADG, FCR and plasma P values in birds fed NC diets supplemented with 4000 U/Kg phytase enzyme (with or without CA significantly reached those of birds fed the PC diet. But, addition of phytase enzyme at 1000 U/Kg only plus CA to the NC diet could significantly improve FCR and plasma P. A significant interaction was observed between phytase and CA for FCR and plasma P. Although TA values in NC + 1000 U/Kg phytase treatments (with or without CA were similar to the PC treatment, TA values of NC + 4000 U/Kg phytase treatments (with or without CA was greater than that of the PC treatment. Results of this study showed that, in severely limited Pa corn-canola meal-based diets, supplementing 4000 U/Kg phytase or also 1000 U/Kg phytase plus CA will be sufficient to obtain the comparable feed efficiency in broilers to those fed the adequate Pa diet.

  3. Criblage et performances agronomiques de 45 génotypes de pois chiche (Cicer arietinum L. soumis à un régime hydrique limité

    Directory of Open Access Journals (Sweden)

    Ben Mbarek K.

    2009-01-01

    Full Text Available Screening and agronomic performances of 45 chickpea genotypes (Cicer arietinum L. submitted to a limited hydrous pattern. In Tunisia, chickpea (Cicer arietinum L. is one of the most important legume grain crops. It is conducted during two periods of the year either as winter crop or as spring crop. The last type has the advantage to occupy the soil in a short period of time (February to June. However, it exposes plants to water stress. Consequently, vegetative development and grain yield are negatively affected in quantity and quality. In order to study plant reactions to drought conditions, 45 genotypes of chickpea (C. arietinum were tested in delayed spring culture under a water stressed treatment. A field trial was carried out in the region of Chott Mariem belonging to the semi-arid superior. The drought stress is established at the beginning of flowering stage and was accentuated during the grain filling and the seed maturity phases. To evaluate the chickpea genotypes stress tolerance, parameters related to the vegetative development, the seed yield, the water use efficiency and the thermal duration were measured. The analysis of the grain yield and its components revealed that there is a biological diversity among the genotypes tested. The 45 accessions can be divided into three groups. The first one is composed of ‘Kabuli’ chickpea genotypes which are sensitive to drought stress. They are not appropriate for spring crop in semi-arid regions. The second group is composed of genotypes, of which two are of ‘Dési’ type, that are tolerant to drought stress and can be recommended for a spring crop in the superior semi-arid zones. The last group of genotypes is moderately sensitive to drought stress. They can be led as spring crop in the semi-arid superior zones with complementary irrigations.

  4. Evaluation of suitability of AMT single crystal for optical limiting applications by performing structural, dielectric, mechanical, optical and third order nonlinearity characterization studies

    Science.gov (United States)

    Elavarasu, N.; Sathya, P.; Pugazhendhi, S.; Vijayan, N.; Maurya, K. K.; Gopalakrishnan, R.

    2016-10-01

    Ammonium D,L-Tartrate (AMT) single crystal for optical and photonic device application was analyzed with different characterization studies. The AMT crystal was grown by low cost conventional solution growth technique. The unit cell parameters were obtained from single crystal XRD analysis and the crystal system is confirmed to be orthorhombic with noncentrosymmetric space group P212121. The crystalline perfection evaluated by high resolution X-ray diffractometry (HRXRD) enumerates the quality of the crystal is good. The optical transparency window of AMT crystal has 78% transmittance from 234 nm to 1100 nm region and has lower cut-off wavelength of 234 nm was analyzed by UV-visible spectral studies. The hardness number (Hv), yield strength (σy) and elastic stiffness constant (C11) were evaluated from the hardness data using Vickers hardness tester. Dielectric study indicates the moderate dielectric constant and low dielectric loss of AMT crystal which are required properties to develop optoelectronic devices. The laser damage threshold value of AMT is 0.238 GW/cm2 and photoconductivity study reveals the positive photoconductivity nature of the AMT crystal. The particle size dependent SHG studies were performed using Nd:YAG laser. The SHG efficiency of AMT is found to be 1.3 times greater than the standard KDP crystal. Third order nonlinear susceptibility χ(3) of AMT was assessed using an open aperture and closed aperture Z-scan technique and the value is 6.71×10-6 esu. AMT crystal is found to exhibit good optical power limiting. The present work indicates that AMT is a potential material for optoelectronic and nonlinear optical devices.

  5. Recovery Efficiency, False Negative Rate, and Limit of Detection Performance of a Validated Macrofoam-Swab Sampling Method with Low Surface Concentrations of Two Bacillus anthracis Surrogates

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hutchison, Janine R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Deatherage Kaiser, Brooke L [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Amidan, Brett G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sydor, Michael A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Barrett, Christopher A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-03-31

    The performance of a macrofoam-swab sampling method was evaluated using Bacillus anthracis Sterne (BAS) and Bacillus atrophaeus Nakamura (BG) spores applied at nine low target amounts (2-500 spores) to positive-control plates and test coupons (2 in. × 2 in.) of four surface materials (glass, stainless steel, vinyl tile, and plastic). Test results from cultured samples were used to evaluate the effects of surrogate, surface concentration, and surface material on recovery efficiency (RE), false negative rate (FNR), and limit of detection. For RE, surrogate and surface material had statistically significant effects, but concentration did not. Mean REs were the lowest for vinyl tile (50.8% with BAS, 40.2% with BG) and the highest for glass (92.8% with BAS, 71.4% with BG). FNR values ranged from 0 to 0.833 for BAS and 0 to 0.806 for BG, with values increasing as concentration decreased in the range tested (0.078 to 19.375 CFU/cm2, where CFU denotes ‘colony forming units’). Surface material also had a statistically significant effect. A FNR-concentration curve was fit for each combination of surrogate and surface material. For both surrogates, the FNR curves tended to be the lowest for glass and highest for vinyl title. The FNR curves for BG tended to be higher than for BAS at lower concentrations, especially for glass. Results using a modified Rapid Viability-Polymerase Chain Reaction (mRV-PCR) analysis method were also obtained. The mRV-PCR results and comparisons to the culture results will be discussed in a subsequent report.

  6. Hemoglobin allostery: new views on old players.

    Science.gov (United States)

    Miele, Adriana Erica; Bellelli, Andrea; Brunori, Maurizio

    2013-05-13

    Proteins are dynamic molecular machines whose structure and function are modulated by environmental perturbations and natural selection. Allosteric regulation, discovered in 1963 as a novel molecular mechanism of enzymatic adaptation [Monod, Changeux & Jacob (1963). J. Mol. Biol.6, 306-329], seems to be the leit motiv of enzymes and metabolic pathways, enabling fine and quick responses toward external perturbations. Hemoglobin (Hb), the oxygen transporter of all vertebrates, has been for decades the paradigmatic system to test the validity of the conformational selection mechanism, the conceptual innovation introduced by Monod, Wyman and Changeux. We present hereby the results of a comparative analysis of structure, function and thermodynamics of two extensively investigated hemoglobins: human HbA and trout HbI. They represent a unique and challenging comparison to test the general validity of the stereochemical model proposed by Perutz. Indeed both proteins are ideal for the purpose being very similar yet very different. In fact, T-HbI is a low-ligand-affinity cooperative tetrameric Hb, insensitive to all allosteric effectors. This remarkable feature, besides being physiologically sound, supports the stereochemical model, given that the six residues identified in HbA as responsible for the Bohr and the 2,3-di-phosphoglycerate effects are all mutated. Comparison of the three-dimensional structures of HbA and T-HbI allows unveiling the molecular mechanism whereby the latter has a lower O2 affinity. Moreover, the energetic balance sheet shows that the salt bridges breaking upon allosteric quaternary transition are important yet insufficient to account for the free energy of heme-heme interactions in both hemoglobins.

  7. Ack1: activation and regulation by allostery.

    Directory of Open Access Journals (Sweden)

    Ketan S Gajiwala

    Full Text Available The non-receptor tyrosine kinase Ack1 belongs to a unique multi-domain protein kinase family, Ack. Ack is the only family of SH3 domain containing kinases to have an SH3 domain following the kinase domain; others have their SH3 domains preceding the kinase domain. Previous reports have suggested that Ack1 does not require phosphorylation for activation and the enzyme activity of the isolated kinase domain is low relative to other kinases. It has been shown to dimerize in the cellular environment, which augments its enzyme activity. The molecular mechanism of activation, however, remains unknown. Here we present structural and biochemical data on Ack1 kinase domain, and kinase domain+SH3 domain that suggest that Ack1 in its monomeric state is autoinhibited, like EGFR and CDK. The activation of the kinase domain may require N-lobe mediated symmetric dimerization, which may be facilitated by the N-terminal SAM domain. Results presented here show that SH3 domain, unlike in Src family tyrosine kinases, does not directly control the activation state of the enzyme. Instead we speculate that the SH3 domain may play a regulatory role by facilitating binding of the MIG6 homologous region to the kinase domain. We postulate that features of Ack1 activation and regulation parallel those of receptor tyrosine kinase EGFR with some interesting differences.

  8. Limited Neutrality

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul

    2006-01-01

    Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."......Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."...

  9. Limiting Skepticism

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella; Symons, John

    2011-01-01

    Skeptics argue that the acquisition of knowledge is impossible given the standing possibility of error. We present the limiting convergence strategy for responding to skepticism and discuss the relationship between conceivable error and an agent’s knowledge in the limit. We argue that the skeptic...

  10. Limited Neutrality

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul

    2006-01-01

    Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."......Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."...

  11. PERFORMANCE

    Directory of Open Access Journals (Sweden)

    M Cilli

    2014-10-01

    Full Text Available This study aimed to investigate the kinematic and kinetic changes when resistance is applied in horizontal and vertical directions, produced by using different percentages of body weight, caused by jumping movements during a dynamic warm-up. The group of subjects consisted of 35 voluntary male athletes (19 basketball and 16 volleyball players; age: 23.4 ± 1.4 years, training experience: 9.6 ± 2.7 years; height: 177.2 ± 5.7 cm, body weight: 69.9 ± 6.9 kg studying Physical Education, who had a jump training background and who were training for 2 hours, on 4 days in a week. A dynamic warm-up protocol containing seven specific resistance movements with specific resistance corresponding to different percentages of body weight (2%, 4%, 6%, 8%, 10% was applied randomly on non consecutive days. Effects of different warm-up protocols were assessed by pre-/post- exercise changes in jump height in the countermovement jump (CMJ and the squat jump (SJ measured using a force platform and changes in hip and knee joint angles at the end of the eccentric phase measured using a video camera. A significant increase in jump height was observed in the dynamic resistance warm-up conducted with different percentages of body weight (p 0.05. In jump movements before and after the warm-up, while no significant difference between the vertical ground reaction forces applied by athletes was observed (p>0.05, in some cases of resistance, a significant reduction was observed in hip and knee joint angles (p<0.05. The dynamic resistance warm-up method was found to cause changes in the kinematics of jumping movements, as well as an increase in jump height values. As a result, dynamic warm-up exercises could be applicable in cases of resistance corresponding to 6-10% of body weight applied in horizontal and vertical directions in order to increase the jump performance acutely.

  12. Effect of high-dose phytase and citric acid, alone or in combination, on growth performance of broilers given diets severely limited in available phosphorus.

    Science.gov (United States)

    Taheri, H R; Jabbari, Z; Adibnia, S; Shahir, M H; Hosseini, S A

    2015-01-01

    1. Two trials were conducted to evaluate the effect of high-dose phytase alone or in combination with citric acid (CA) in the diet severely limited in available phosphorus (P) on performance, plasma P and plasma Ca of broilers from 22 to 42 d of age. 2. In Trial 1, 297 21-d-old female chicks were placed into 27 pens and allocated to 9 maize-soybean meal-based dietary treatments, which were a positive control [PC, 4.23 g/kg non-phytate P (NPP)] and 8 negative control (NC, 1.35 g/kg NPP) groups consisting of two concentrations of CA (0 and 20 g/kg) and 4 concentrations of phytase (0, 1000, 2000 and 4000 U/kg) in a 2 × 4 factorial arrangement. In Trial 2, 192 21-d-old male chicks were placed into 24 pens and allocated to 6 wheat-canola meal-based dietary treatments, which were a PC (4.2 g/kg NPP), a NC (1.68 g/kg NPP) and 4 NC groups consisting of two concentrations of CA (0 and 20 g/kg) and two concentrations of phytase (2000 and 4000 U/kg) in a 2 × 2 factorial arrangement. 3. In both trials, birds fed on the PC had significantly higher average daily gain (ADG), average daily feed intake (ADFI), plasma P and lower feed conversion ratio (FCR) and plasma Ca than those of birds fed on the NC. CA supplementation significantly increased ADG and ADFI. There was a significant interaction between CA and phytase on plasma P where CA improved the effect of phytase on plasma P. In Trial 1, phytase addition improved ADG, ADFI, FCR and plasma Ca linearly. 4. Briefly, this research showed the interaction effect between CA and phytase on plasma P when broilers were fed on diets based on maize-soybean meal or wheat-canola meal. The results showed that CA supplementation lowered the concentration of phytase that is needed in low NPP diets to increase plasma P.

  13. Inverse Limits

    CERN Document Server

    Ingram, WT

    2012-01-01

    Inverse limits provide a powerful tool for constructing complicated spaces from simple ones. They also turn the study of a dynamical system consisting of a space and a self-map into a study of a (likely more complicated) space and a self-homeomorphism. In four chapters along with an appendix containing background material the authors develop the theory of inverse limits. The book begins with an introduction through inverse limits on [0,1] before moving to a general treatment of the subject. Special topics in continuum theory complete the book. Although it is not a book on dynamics, the influen

  14. Two Decades of WRF/CMAQ simulations over the continental United States: New approaches for performing dynamic model evaluation and determining confidence limits for ozone exceedances

    Science.gov (United States)

    Confidence in the application of models for forecasting and regulatory assessments is furthered by conducting four types of model evaluation: operational, dynamic, diagnostic, and probabilistic. Operational model evaluation alone does not reveal the confidence limits that can be ...

  15. Effect of nitrite, limited reactive settler and plant design configuration on the predicted performance of simultaneous C/N/P removal WWTPs.

    Science.gov (United States)

    Guerrero, Javier; Flores-Alsina, Xavier; Guisasola, Albert; Baeza, Juan A; Gernaey, Krist V

    2013-05-01

    This paper describes a modelling study where five new benchmark plant design configurations for biological nutrient removal (A(2)/O, UCT, JHB, MUCT and BDP-5 stage) are simulated and evaluated under different model assumptions. The ASM2d including electron dependent decay rates is used as the reference model (A1). The second case (A2) adds nitrite as a new state variable, describing nitrification and denitrification as two-step processes. The third set of models (A3 and A4) considers different reactive settlers types (diffusion-limited/non limited). This study analyses the importance of these new model extensions to correctly describe the nitrification behaviour and the carbon source competition between ordinary heterotrophic organisms (OHO) and polyphosphate accumulating organisms (PAO) under certain operation conditions. The economic and environmental aspects when meeting the P discharge limits by adding an external carbon source are also studied.

  16. Limits on $\

    CERN Document Server

    Perego, D L

    2002-01-01

    A limit on the tau neutrino mass is obtained using all the $Z^{0} \\to \\tau^{+} \\tau^{-}$ data collected at LEP by the DELPHI detector between 1992 and 1995. In this analysis events in which one of the taus decays into one charged particle, while the second $\\tau$ decays into f{}ive charged pions (1-5 topology) have been used. The neutrino mass is determined from a bidimensional \\fit ~on the invariant mass $m^{*}_{5 \\pi}$ and on the energy $E_{5 \\pi}$ of the f{}ive $\\pi^{\\pm}$ system. The result found is $m_{\

  17. Fatigue as a long-term risk factor for limitations in instrumental activities of daily living and/or mobility performance in older adults after 10 years

    NARCIS (Netherlands)

    Mueller-Schotte, Sigrid; Bleijenberg, Nienke; van der Schouw, Yvonne T.; Schuurmans, Marieke J.

    2016-01-01

    Objectives: Decline in the performance of instrumental activities of daily living (IADL) and mobility may be preceded by symptoms the patient experiences, such as fatigue. The aim of this study is to investigate whether self-reported non-task-specific fatigue is a long-term risk factor for IADL-limi

  18. Growth performance and total tract nutrient digestion for Holstein heifers limit-fed diets high in distillers grains with different forage particle size

    Science.gov (United States)

    This study evaluated dairy heifer growth performance and total tract nutrient digestion when fed diets high in dried distillers grains with solubles (DDGS) with different forage particle size. An 8-wk randomized complete block design study was conducted utilizing twenty-two Holstein heifers (123 ±...

  19. 40 CFR 63.3167 - How do I establish the add-on control device operating limits during the performance test?

    Science.gov (United States)

    2010-07-01

    ... three test runs. You must monitor the temperature in the firebox of the thermal oxidizer or immediately... April 26, 2007, for the thermal oxidizer at your facility contains recordkeeping and reporting... the average combustion temperature during the performance test of that thermal oxidizer. If you do...

  20. Limit of detection studies for application to natural product identification using high performance liquid chromatography coupled to nuclear magnetic resonance spectroscopy.

    Science.gov (United States)

    Brkljača, Robert; Urban, Sylvia

    2015-01-02

    In the pursuit of new natural products, the demand to rapidly identify compounds present, in ever decreasing amounts, in complex crude extracts has become a limiting factor. Despite improvements in HPLC-NMR hardware and pulse sequences, no extensive limit of detection (LOD) investigations have been reported for the acquisition of 2D NMR spectroscopic experiments acquired through HPLC-NMR. In this study the LOD for five key 1D and 2D NMR spectroscopic experiments have been established, using two reference compounds, including the on-flow (WET 1D proton), stop-flow (WET1D proton), gCOSY, HSQCAD and gHMBCAD NMR experiments. The LOD for all of the NMR experiments were within the range of 700ng to 1mg for the set of fixed experimental parameters implemented. For principle components in a complex multi-component mixture, this would allow for in situ compound identification. HPLC-NMR analysis was employed to investigate the principle components present in a marine brown alga crude extract, Cystophora subfarcinata.

  1. Influence of temporal noise on the skin blood flow measurements performed by cooled thermal imaging camera: limit possibilities within each physiological frequency range

    Science.gov (United States)

    Sagaidachnyi, A. A.; Volkov, I. U.; Fomin, A. V.

    2016-04-01

    This paper describes limit possibilities of modern cooled thermal imaging cameras as a tool for estimation of blood flow oscillations at the surface of living body. Skin temperature oscillations, as we assumed, are a consequence of the blood flow oscillations. We considered the temperature sensitivity 0.01-0.02 °C as a typical for the most of modern cooled long wave thermal imaging cameras. Fourier filter used to investigate the temperature signal separately within endothelial, neurogenic, myogenic, respiratory and cardiac frequency ranges. The level of temporal noise has been estimated during measurements of no living body with stabilized temperature ~ 24°C. The level of temperature oscillations has been calculated for the group of healthy subjects within each frequency range. Thus, we were able to determine signal-to-noise ratio within frequency band [0.001, 1] Hz. As a result, we determine that skin temperature oscillations measured by thermal imaging camera with sensitivity 0.02°C have the upper frequency limit ~ 0.2 Hz. In other words, within the respiratory and cardiac frequency ranges of blood flow oscillations the noise level exceeds signal one, and temperature measurements at the skin surface are practically useless. The endothelial, neurogenic and myogenic components of the temperature oscillations contain ~98% of the total spectral power of the signal. We have plot the empirical extrapolated curve of sensitivity of thermal imaging camera vs. frequency of the temperature oscillations. The data analysis shows that measurements of skin temperature oscillations within respiratory and cardiac ranges require the temperature sensitivity at least ~ 0.01°C and 0.001°C, respectively.

  2. End-point limiting-dilution real-time PCR assay for evaluation of hepatitis C virus quasispecies in serum: performance under optimal and suboptimal conditions.

    Science.gov (United States)

    Ramachandran, Sumathi; Xia, Guo-Liang; Ganova-Raeva, Lilia M; Nainan, Omana V; Khudyakov, Yury

    2008-08-01

    An approach for determination of hepatitis C virus (HCV) quasispecies by end-point limiting-dilution real-time PCR (EPLD-PCR) is described. It involves isolation of individual coexisting sequence variants of the hypervariable region 1 (HVR1) of the HCV genome from serum specimens using a limiting-dilution protocol. EPLD-PCR applied to an HCV outbreak study provided insights into the epidemiological relationships between incident and chronic cases. When applied to samples from a longitudinal study of infected patients, HVR1 sequences from each sampling time-point were observed to group as distinct phylogenetic clusters. Melting peak analysis conducted on EPLD-PCR products generated from these patients could be used for evaluation of HVR1 sequence heterogeneity without recourse to clonal sequencing. Further, to better understand the mechanism of single-molecule PCR, experiments were conducted under optimal and suboptimal annealing temperatures. Under all temperature conditions tested, HVR1 variants from the major phylogenetic clusters of quasispecies could be amplified, revealing that successful HVR1 quasispecies analysis is not contingent to dilution of starting cDNA preparations to a single-molecule state. It was found that EPLD-PCR conducted at suboptimal annealing temperatures generated distributions of unique-sequence variants slightly different from the distribution obtained by PCR conducted at the optimal temperature. Hence, EPLD-PCR conditions can be manipulated to access different subpopulations of HCV HVR1 quasispecies, thus, improving the range of the quasispecies detection. Although EPLD-PCR conducted at different conditions detect slightly different quasispecies populations, as was shown in this study, the resulted samples of quasispecies are completely suitable for molecular epidemiological investigation in different clinical and epidemiological settings.

  3. Task failure during exercise to exhaustion in normoxia and hypoxia is due to reduced muscle activation caused by central mechanisms while muscle metaboreflex does not limit performance

    Directory of Open Access Journals (Sweden)

    Rafael eTorres-Peralta

    2016-01-01

    Full Text Available To determine whether task failure during incremental exercise to exhaustion (IE is principally due to reduced neural drive and increased metaboreflex activation eleven men (22±2 years performed a 10s control isokinetic sprint (IS; 80 rpm after a short warm-up. This was immediately followed by an IE in normoxia (Nx, PIO2:143 mmHg and hypoxia (Hyp, PIO2:73 mmHg in random order, separated by a 120 min resting period. At exhaustion, the circulation of both legs was occluded instantaneously (300 mmHg during 10 or 60s to impede recovery and increase metaboreflex activation. This was immediately followed by an IS with open circulation. Electromyographic recordings were obtained from the vastus medialis and lateralis. Muscle biopsies and blood gases were obtained in separate experiments. During the last 10s of the IE, pulmonary ventilation, VO2, power output and muscle activation were lower in hypoxia than in normoxia, while pedaling rate was similar. Compared to the control sprint, performance (IS-Wpeak was reduced to a greater extent after the IE-Nx (11% lower P<0.05 than IE-Hyp. The root mean square (EMGRMS was reduced by 38 and 27% during IS performed after IE-Nx and IE-Hyp, respectively (Nx vs. Hyp: P<0.05. Post-ischemia IS-EMGRMS values were higher than during the last 10s of IE. Sprint exercise mean (IS-MPF and median (IS-MdPF power frequencies, and burst duration, were more reduced after IE-Nx than IE-Hyp (P<0.05. Despite increased muscle lactate accumulation, acidification, and metaboreflex activation from 10 to 60s of ischemia, IS-Wmean (+23% and burst duration (+10% increased, while IS-EMGRMS decreased (-24%, P<0.05, with IS-MPF and IS-MdPF remaining unchanged. In conclusion, close to task failure, muscle activation is lower in hypoxia than in normoxia. Task failure is predominantly caused by central mechanisms, which recover to great extent within one minute even when the legs remain ischemic. There is dissociation between the recovery of

  4. Effect of limit feeding high- and low-concentrate diets with Saccharomyces cerevisiae on digestibility and on dairy heifer growth and first-lactation performance.

    Science.gov (United States)

    Lascano, G J; Zanton, G I; Suarez-Mena, F X; Heinrichs, A J

    2009-10-01

    Growth and digestibility were examined for heifers limit fed high- (HC; 60%) and low-concentrate (LC; 20%) diets with or without yeast culture (YC) addition in 2 experiments. A third experiment was undertaken to monitor first-lactation production of heifers limit fed HC or LC diets. In experiment 1, 32 Holstein heifers were individually fed at controlled intakes for 133 d to maintain a targeted average daily gain of 0.80 kg/d for all 4 treatments [HC; LC with and without Saccharomyces cerevisiae; Yea-Sacc(1026) (Alltech Inc., Nicholasville, KY), 1 g/kg as fed]. Targeted average daily gain was achieved for all treatments during the individual feeding period (0.80 +/- 0.01 kg/d). Average dry matter intake needed to maintain constant gain was slightly reduced for HC and YC treatments. Reduced dry matter intake and similar targeted average daily gain resulted in a tendency for improved feed efficiency of HC-fed heifers. Skeletal measurements and targeted average daily gain were not affected by concentrate level or YC. The objective of experiment 2 was to elucidate effects of concentrate level and YC on nutrient digestibility. Four young (284.35 +/- 4.51 d) and 4 older (410.28 +/- 2.14 d) heifers were allocated to the 4 treatments used in experiment 1. Heifers fed the HC diet had increased dry matter digestibility (75.67 vs.72.96 +/- 0.72%), and YC addition increased dry matter digestibility (74.97 vs. 73.65 +/- 0.71%). Intake of N and apparent N digestibility were similar for all treatments. High-concentrate diets and YC addition decreased wet and dry matter output of feces. Urine excretion was not different; therefore, total manure output was lower for HC-fed heifers as compared with LC-fed heifers. Results suggest that HC diets can improve feed efficiency without affecting growth when limit fed to dairy heifers. Yeast culture increased dry matter digestibility in HC- and LC-fed heifers; HC diets were more digestible and reduced fecal output, with YC enhancing this

  5. Limited potential of genetic predisposition scores to predict muscle mass and strength performance in Flemish Caucasians between 19-73 years of age.

    Science.gov (United States)

    Charlier, Ruben; Caspers, Maarten; Knaeps, Sara; Mertens, Evelien; Lambrechts, Diether; Lefevre, Johan; Thomis, Martine

    2016-12-30

    Since both muscle mass and strength performance are polygenic in nature, the current study compared four Genetic Predisposition Scores (GPS) in their ability to predict these phenotypes. Data were gathered within the framework of the first generation Flemish Policy Research Centre 'Sport, Physical Activity and Health' (2002-2004). Results are based on muscle characteristics data of 565 Flemish Caucasians (19-73 yr, 365 men). Skeletal muscle mass (SMM) was determined using bioelectrical impedance. The Biodex dynamometer was used to measure isometric (PTstatic120°) and isokinetic strength (PTdynamic60° and PTdynamic240°), ballistic movement speed (S20%) and muscular endurance (Work) of the knee extensors. Genotyping was done for 153 gene variants selected based on a literature search and the expression Quantitative Trait Loci of selected genes. Four GPS were designed: a total GPS (based on the sum of all 153 variants, each favorable allele = score 1), a data-driven and weighted GPS (respectively the sum of favorable alleles of those variants with significant b-coefficients in stepwise regression (GPSdd) and the sum of these variants weighted with their respective partial r² (GPSw)) and an elastic net GPS (based on the variants that were selected by an elastic net regularization; GPSen). It was found that four different models for a GPS were able to significantly predict up to ~7% of the variance in strength performance. GPSen made the best prediction of SMM and Work. However, this was not the case for the remaining strength performance parameters, where best predictions were made by GPSdd and GPSw.

  6. Performance of optimal hierarchical type 2 fuzzy controller for load–frequency system with production rate limitation and governor dead band

    Directory of Open Access Journals (Sweden)

    Mohsen Ebrahimian Baydokhty

    2016-03-01

    It would be useful to make use of the type 2 fuzzy in modeling of uncertainties in systems which are uncertain. In the present article, first, the simplified 4-block type-2 fuzzy has been used for modeling the fuzzy system. Then, fuzzy system regulations are reduced by 33% with the help of hierarchy fuzzy structure. The simplified type-2 fuzzy controller is optimized using the Cuckoo algorithm. Eventually, the performance of the proposed controller is compared to the Mamdani fuzzy controller in terms of the ISE, ITSE, and RMS criteria.

  7. Creativity and working memory capacity in sports: working memory capacity is not a limiting factor in creative decision making amongst skilled performers

    Science.gov (United States)

    Furley, Philip; Memmert, Daniel

    2015-01-01

    The goal of the study was to investigate the relationship between domain-general working memory capacity and domain-specific creativity amongst experienced soccer players. We administered the automated operation span task in combination with a domain-specific soccer creativity task to a group of 61 experienced soccer players to address the question whether an athlete’s domain-specific creativity is restricted by their domain-general cognitive abilities (i.e., working memory capacity). Given that previous studies have either found a positive correlation, a negative correlation, or no correlation between working memory capacity and creativity, we analyzed the data in an exploratory manner by following recent recommendations to report effect-size estimations and their precision in form of 95% confidence intervals. The pattern of results provided evidence that domain-general working memory capacity is not associated with creativity in a soccer-specific creativity task. This pattern of results suggests that future research and theorizing on the role of working memory in everyday creative performance needs to distinguish between different types of creative performance while also taking the role of domain-specific experience into account. PMID:25713552

  8. Creativity and Working Memory Capacity in Sports: Working Memory Capacity Is not a Limiting Factor in Creative Decision Making amongst Skilled Performers

    Directory of Open Access Journals (Sweden)

    Philip eFurley

    2015-02-01

    Full Text Available The goal of the study was to investigate the relationship between domain-general working memory capacity and domain-specific creativity amongst experienced soccer players. We administered the automated operation span task in combination with a domain-specific soccer creativity task to a group of 61 experienced soccer players to address the question whether an athlete’s domain-specific creativity is restricted by their domain-general cognitive abilities (i.e. working memory capacity. Given that previous studies have either found a positive correlation, a negative correlation, or no correlation between working memory capacity and creativity, we analyzed the data in an exploratory manner by following recent recommendations to report effect-size estimations and their precision in form of 95% confidence intervals. The pattern of results provided evidence that domain-general working memory capacity is not associated with creativity in a soccer-specific creativity task. This pattern of results suggests that future research and theorizing on the role of working memory in everyday creative performance needs to distinguish between different types of creative performance while also taking the role of domain-specific experience into account.

  9. Age Limits.

    Science.gov (United States)

    Antfolk, Jan

    2017-03-01

    Whereas women of all ages prefer slightly older sexual partners, men-regardless of their age-have a preference for women in their 20s. Earlier research has suggested that this difference between the sexes' age preferences is resolved according to women's preferences. This research has not, however, sufficiently considered that the age range of considered partners might change over the life span. Here we investigated the age limits (youngest and oldest) of considered and actual sex partners in a population-based sample of 2,655 adults (aged 18-50 years). Over the investigated age span, women reported a narrower age range than men and women tended to prefer slightly older men. We also show that men's age range widens as they get older: While they continue to consider sex with young women, men also consider sex with women their own age or older. Contrary to earlier suggestions, men's sexual activity thus reflects also their own age range, although their potential interest in younger women is not likely converted into sexual activity. Compared to homosexual men, bisexual and heterosexual men were more unlikely to convert young preferences into actual behavior, supporting female-choice theory.

  10. Multiplex real-time quantitative PCR, microscopy and rapid diagnostic immuno-chromatographic tests for the detection of Plasmodium spp: performance, limit of detection analysis and quality assurance

    Directory of Open Access Journals (Sweden)

    Ralevski Filip

    2009-12-01

    Full Text Available Abstract Background Accurate laboratory diagnosis of malaria species in returning travelers is paramount in the treatment of this potentially fatal infectious disease. Materials and methods A total of 466 blood specimens from returning travelers to Africa, Asia, and South/Central America with suspected malaria infection were collected between 2007 and 2009 at the reference public health laboratory. These specimens were assessed by reference microscopy, multipex real-time quantitative polymerase chain reaction (QPCR, and two rapid diagnostic immuno-chromatographic tests (ICT in a blinded manner. Key clinical laboratory parameters such as limit of detection (LOD analysis on clinical specimens by parasite stage, inter-reader variability of ICTs, staffing implications, quality assurance and cost analysis were evaluated. Results QPCR is the most analytically sensitive method (sensitivity 99.41%, followed by CARESTART (sensitivity 88.24%, and BINAXNOW (sensitivity 86.47% for the diagnosis of malaria in returning travelers when compared to reference microscopy. However, microscopy was unable to specifically identify Plasmodia spp. in 18 out of 170 positive samples by QPCR. Moreover, the 17 samples that were negative by microscopy and positive by QPCR were also positive by ICTs. Quality assurance was achieved for QPCR by exchanging a blinded proficiency panel with another reference laboratory. The Kappa value of inter-reader variability among three readers for BINAXNOW and CARESTART was calculated to be 0.872 and 0.898 respectively. Serial dilution studies demonstrated that the QPCR cycle threshold correlates linearly with parasitemia (R2 = 0.9746 in a clinically relevant dynamic range and retains a LOD of 11 rDNA copies/μl for P. falciparum, which was several log lower than reference microscopy and ICTs. LOD for QPCR is affected not only by parasitemia but the parasite stage distribution of each clinical specimen. QPCR was approximately 6-fold more

  11. Limiting Concentrate during Growing Period Affect Performance and Gene Expression of Hepatic Gluconeogenic Enzymes and Visfatin in Korean Native Beef Calves

    Directory of Open Access Journals (Sweden)

    S. S. Chang

    2013-02-01

    Full Text Available This study elucidated the effects of limited concentrate feeding on growth, plasma profile, and gene expression of gluconeogenic enzymes and visfatin in the liver of Hanwoo beef calves. The purpose of this study was to test that reducing the amount of concentrate would partially be compensated by increasing the intake of forage and by altering the metabolic status. The study utilized 20 Korean native beef calves (Hanwoo; 60 to 70 d of age divided into two groups of 10 calves each for 158 d. Control group calves received the amount of concentrate as per the established Korean feeding standards for Hanwoo, whereas calves in the restricted group only received half the amount of concentrate as per standard requirements. Good quality forage (Timothy hay was available for ad libitum consumption to both groups. Since calves were with their dam until 4 months of age in breeding pens before weaning, the intake of milk before weaning was not recorded, however, the concentrate and forage intakes were recorded daily. Body weights (BW were recorded at start and on 10 d interval. Blood samples were collected at start and at 50 d interval. On the final day of the experiment, liver biopsies were collected from all animals in each group. The BW was not different between the groups at all times, but tended to be higher (p = 0.061 only at final BW in control than restricted group. Total BW gain in the control group was 116.2 kg as opposed to 84.1 kg in restricted group that led to average BW gain of 736 g/d and 532 g/d in respective groups, and the differences were significant (p<0.01. As planned, the calves in the control group had higher concentrate and lower forage intake than the restricted group. The plasma variables like total protein and urea were higher (p<0.05 in control than restricted group. The mRNA expressions for the gluconeogenic enzymes such as cytosolic phosphoenol pyruvate carboxykinase (EC 4.1.1.32 and pyruvate carboxylase (EC 6.4.1.1, and

  12. Efficacy of an Exercise and Nutritional Supplement Program on Physical Performance and Nutritional Status in Older Adults With Mobility Limitations Residing at Senior Living Facilities.

    Science.gov (United States)

    Corcoran, Michael P; Nelson, Miriam E; Sacheck, Jennifer M; Reid, Kieran F; Kirn, Dylan; Fielding, Roger A; Chui, Kenneth K H; Folta, Sara C

    2017-01-17

    This cluster-randomized trial was designed to determine the efficacy of a 6-month exercise-nutritional supplement program (ENP) on physical function and nutritional status for older adults and the feasibility of implementing this program in a senior living setting. Twenty senior living facilities were randomized to either a three day per week group-based ENP led by a trained facility staff member or a health education program (SAP). Participants (N=121) completed a short physical performance battery, 400 meter walk, handgrip strength test, and mini-nutrition assessment. 25-hydroxyvitamin D [25(OH)D], Insulin-like growth-factor 1 (IGF-1) and activity level were also measured. The ENP did not significantly improve physical function or nutritional status compared with the SAP. Compared with baseline, participants in the ENP engaged in 39 minutes less physical activity per week at 6-months. Several facility characteristics hindered implementation of the ENP. This study highlights the complexity of implementing an evidence-based program in a field setting.

  13. Outdoor passive air monitoring of semi volatile organic compounds (SVOCs): a critical evaluation of performance and limitations of polyurethane foam (PUF) disks.

    Science.gov (United States)

    Bohlin, P; Audy, O; Škrdlíková, L; Kukučka, P; Přibylová, P; Prokeš, R; Vojta, Š; Klánová, J

    2014-03-01

    The most commonly used passive air sampler (PAS) (i.e. polyurethane foam (PUF) disk) is cheap, versatile, and capable of accumulating compounds present both in gas and particle phases. Its performance for particle associated compounds is however disputable. In this study, twelve sets of triplicate PUF-PAS were deployed outdoors for exposure periods of 1-12 weeks together with continuously operated active samplers, to characterize sampling efficiency and derive sampling rates (RS) for compounds belonging to 7 SVOC classes (including particle associated compounds). PUF-PAS efficiently and consistently sampled polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polycyclic aromatic hydrocarbons (PAHs), and eight novel brominated flame retardant (nBFR) compounds. Low accuracy and lack of sensitivity was observed for most polychlorinated dibenzo-p-dioxins/furans PCDD/Fs and polybrominated diphenyl ethers (PBDEs) (under the conditions of this study), with the exception of some congeners which may be used as qualitative markers for their respective classes. Application of compound specific RS was found crucial for all compounds except PCBs. Sampling efficiency of the particle associated compounds was often low.

  14. The Limits of Exercise Physiology

    DEFF Research Database (Denmark)

    Gabriel, Brendan M; Zierath, Juleen R

    2017-01-01

    Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have...

  15. [What are the tools for post-occupational follow-up, how should they be performed and what are their performance, limits and benefit/risk ratio? Chest X-Ray and CT scan].

    Science.gov (United States)

    Ferretti, G

    2011-06-01

    Chest radiography and computed tomography (CT) are the two radiological techniques used for the follow-up of people exposed to asbestos. Since the last conference of consensus (1999), the scientific literature has primarily covered high-resolution CT and high-resolution volume CT (HR-VCT). We consider in turn the contribution of digital thoracic radiography, recommendations for the performance of HR-VCT to ensure the quality of examination while controlling the delivered radiation dose, and the need to refer to the "CT atlas of benign diseases related to asbestos exposure", published by a group of French experts in 2007, for interpretation. The results of the published studies concerning radiography or CT are then reviewed. We note the great interobserver variability in the recognition of pleural plaques and asbestosis, indicating the need for adequate training of radiologists, and the importance of defining standardized, quantified criteria for CT abnormalities. The very low agreement between thoracic and general radiologists must be taken into account. The reading of CT scans in cases of occupational exposure to asbestos should be entrusted to thoracic radiologists or to general radiologists having validated specific training. A double interpretation of CT could be considered in medicosocial requests. CT is more sensitive than chest radiography in the detection of bronchial carcinoma but generates a great number of false positive results (96 to 99%). No scientific data are available to assess the role of imaging by either CT or chest radiography in the early detection of mesothelioma.

  16. Quantum-limit spectroscopy

    CERN Document Server

    Ficek, Zbigniew

    2017-01-01

    This book covers the main ideas, methods, and recent developments of quantum-limit optical spectroscopy and applications to quantum information, resolution spectroscopy, measurements beyond quantum limits, measurement of decoherence, and entanglement. Quantum-limit spectroscopy lies at the frontier of current experimental and theoretical techniques, and is one of the areas of atomic spectroscopy where the quantization of the field is essential to predict and interpret the existing experimental results. Currently, there is an increasing interest in quantum and precision spectroscopy both theoretically and experimentally, due to significant progress in trapping and cooling of single atoms and ions. This progress allows one to explore in the most intimate detail the ways in which light interacts with atoms and to measure spectral properties and quantum effects with high precision. Moreover, it allows one to perform subtle tests of quantum mechanics on the single atom and single photon scale which were hardly eve...

  17. Interference and memory capacity limitations.

    Science.gov (United States)

    Endress, Ansgar D; Szabó, Szilárd

    2017-10-01

    Working memory (WM) is thought to have a fixed and limited capacity. However, the origins of these capacity limitations are debated, and generally attributed to active, attentional processes. Here, we show that the existence of interference among items in memory mathematically guarantees fixed and limited capacity limits under very general conditions, irrespective of any processing assumptions. Assuming that interference (a) increases with the number of interfering items and (b) brings memory performance to chance levels for large numbers of interfering items, capacity limits are a simple function of the relative influence of memorization and interference. In contrast, we show that time-based memory limitations do not lead to fixed memory capacity limitations that are independent of the timing properties of an experiment. We show that interference can mimic both slot-like and continuous resource-like memory limitations, suggesting that these types of memory performance might not be as different as commonly believed. We speculate that slot-like WM limitations might arise from crowding-like phenomena in memory when participants have to retrieve items. Further, based on earlier research on parallel attention and enumeration, we suggest that crowding-like phenomena might be a common reason for the 3 major cognitive capacity limitations. As suggested by Miller (1956) and Cowan (2001), these capacity limitations might arise because of a common reason, even though they likely rely on distinct processes. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  18. Array Antenna Limitations

    CERN Document Server

    Jonsson, B L G; Hussain, N

    2013-01-01

    This letter defines a physical bound based array figure of merit that provides a tool to compare the performance of both single and multi-band array antennas with respect to return-loss, thickness of the array over the ground-plane, and scan-range. The result is based on a sum-rule result of Rozanov-type for linear polarization. For single-band antennas it extends an existing limit for a given fixed scan-angle to include the whole scan-range of the array, as well as the unit-cell structure in the bound. The letter ends with an investigation of the array figure of merit for some wideband and/or wide-scan antennas with linear polarization. We find arrays with a figure of merit >0.6 that empirically defines high-performance antennas with respect to this measure.

  19. HOME Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — HOME Income Limits are calculated using the same methodology that HUD uses for calculating the income limits for the Section 8 program. These limits are based on HUD...

  20. Fundamental Limits of Ultrathin Metasurfaces

    CERN Document Server

    Arbabi, Amir

    2014-01-01

    We present universal theoretical limits on the operation and performance of non-magnetic passive ultrathin metasurfaces. In particular, we prove that their local transmission, reflection, and polarization conversion coefficients are confined to limited regions of the complex plane. As a result, full control over the phase of the light transmitted through such metasurfaces cannot be achieved if the polarization of the light is not to be affected at the same time. We also establish fundamental limits on the maximum polarization conversion efficiency of these metasurfaces, and show that they cannot achieve more than 25% polarization conversion efficiency in transmission.

  1. False-negative rate, limit of detection and recovery efficiency performance of a validated macrofoam-swab sampling method for low surface concentrations of Bacillus anthracis Sterne and Bacillus atrophaeus spores

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, G. F. [Applied Statistics and Computational Sciences, Pacific Northwest National Laboratory, Richland WA USA; Deatherage Kaiser, B. L. [Chemical and Biological Signature Science Group, Pacific Northwest National Laboratory, Richland WA USA; Amidan, B. G. [Applied Statistics and Computational Sciences, Pacific Northwest National Laboratory, Richland WA USA; Sydor, M. A. [Chemical and Biological Signature Science Group, Pacific Northwest National Laboratory, Richland WA USA; Barrett, C. A. [Analytical Chemistry of Nuclear Materials, Pacific Northwest National Laboratory, Richland WA USA; Hutchison, J. R. [Chemical and Biological Signature Science Group, Pacific Northwest National Laboratory, Richland WA USA

    2016-05-06

    The performance of a macrofoam-swab sampling method was evaluated using Bacillus anthracis Sterne (BAS) and Bacillus atrophaeus Nakamura (BG) spores applied at nine low target amounts (2-500 spores) to positive-control plates and test coupons (2 in × 2 in) of four surface materials (glass, stainless steel, vinyl tile, and plastic). Test results from cultured samples were used to evaluate the effects of surrogate, surface concentration, and surface material on recovery efficiency (RE), false negative rate (FNR), and limit of detection. For RE, surrogate and surface material had statistically significant effects, but concentration did not. Mean REs were the lowest for vinyl tile (50.8% with BAS and 40.2% with BG) and the highest for glass (92.8% with BAS and 71.4% with BG). FNR values ranged from 0 to 0.833 for BAS and 0 to 0.806 for BG; values increased as concentration decreased in the range tested (0.078 to 19.375 CFU/cm2). Surface material also had a statistically significant effect. A FNR-concentration curve was fit for each combination of surrogate and surface material. For both surrogates, the FNR curves tended to be the lowest for glass and highest for vinyl title. The FNR curves for BG tended to be higher than for BAS at lower concentrations, especially for glass. Results using a modified Rapid Viability-Polymerase Chain Reaction (mRV-PCR) analysis method were also obtained. The mRV-PCR results and comparisons to the culture results will be discussed in a subsequent article.

  2. Passive immitance limiters

    OpenAIRE

    Filinyuk N. A.; Lischinskaya L. B.; Chekhmestruk R. Yu.

    2015-01-01

    The paper presents quadripole R, L, C immittance limiters, in which output immittance to the certain value depends on the input immittance. A classification of immittance limiters is given. Basic parameters are considered: low and high levels of output immittance limiters; low and high values of input immittance, corresponding to low and high levels of limitation, accordingly; range of possible values of output immittance; steepness of immittance limiters; time of wearing-out (or delay); high...

  3. Research Progress and the Limiting Factors that Affect Performance of the Lithium Air Batteries%锂-空气电池性能的影响因素及研究进展

    Institute of Scientific and Technical Information of China (English)

    顾大明; 张传明; 顾硕; 张音; 王余; 强亮生

    2012-01-01

    锂-空气电池理论比能量高达3622 Wh·kg^-1(设阴极还原产物为Li2O2), 远超过目前已有的任何电池, 有希望成为新一代的二次电池。 然而, 目前其实用化研究还处于探索阶段, 在其商用之前还有许多工作要做。 对影响锂-空气电池性能的因素以及近期的研究进展进行综述, 总结了阴极材料的组成和微观结构、电解质的种类及组成、阴极疏水膜、电池结构设计、电池的组装及充、放电的工艺过程等对电池比能量、比容量以及循环性能等的影响, 概述了锂-空气电池的表征手段, 并对锂-空气电池的应用前景进行了展望。%Lithium air battery has attracted extensive attention due to its potential in achieving much higher practical specific energy than existing batteries, and it may become one of the most promising next generation battery technologies. Lithium air battery has the compelling advantage of theoretical specific energy, i.e. 3622 Wh·kg^-1 (assuming Li2O2 is the product), which is attributed to the use of a lithium metal anode and the ready availability of the cathode oxidant, i.e. oxygen, from the surrounding air. Other advantages include stable potentials, high safety, low cost, friendly to environment. However, before Lithium air batteries can be commercialized, the following challenges still need to be overcome: optimization of the cathode materials structure and the electrolyte composition, enhancement of the actual discharge special capacity, and improvement of the cycle performance and elucidating the reaction mechanism that occurs during charge and discharge. In this paper, we presented the current research progress and the limiting factors that affect performance of the batteries, such as microcomposition and microstructure of the cathode materials, constitution of the electrolytes, oxygen selective membranes, the structure design for the lithium air batteries, charge and discharge mechanism; compared

  4. Políticas e inovação em atenção à saúde mental: limites ao descolamento do desempenho do SUS Policies and innovation in mental healthcare: limits to decoupling from the performance of the SUS

    Directory of Open Access Journals (Sweden)

    José Mendes Ribeiro

    2011-12-01

    Full Text Available Analisamos a política brasileira de saúde mental quanto aos aspectos normativos, de demanda, de oferta e de financiamento. Concluímos que a sustentabilidade das inovações da reforma psiquiátrica depende de melhor financiamento e de integração dos serviços comunitários à rede de atenção primária, do desempenho geral do SUS e da redução de serviços exclusivos e autônomos na atenção primária. Existe elevada e crescente pressão de demanda medida em DALY e carga de doença. A redução dos leitos psiquiátricos observada acompanhou a redução sistêmica, porém com redução seletiva para as internações psiquiátricas. Os CAPS apresentam limites institucionais devido ao modelo adotado de administração pública direta e da capacidade de governo municipais. Dados secundários disponíveis revelam que: (i o SUS tem poder quase monopsônico em serviços ambulatoriais e hospitalares em geral; (ii os profissionais de saúde mental são predominantemente vinculados ao SUS; (iii os serviços de saúde mental têm característica predominantemente extra-hospitalar; (iv um número residual de CAPS dispõem de leitos diários; e (v o financiamento federal para estas inovações é reduzido.We studied Brazilian policies on mental health with respect to normative, supply and demand and financing aspects. We concluded that the sustainability of innovations in psychiatric reform depends on enhanced financing and integration with primary care community services, on the overall performance of SUS and the reduction of autonomous and exclusive services in primary care. There is high and rising pressure in demand for services measured in DALY and the incidence of disease. The reduction observed in psychiatric beds was accompanied by the systemic reduction, though with selective reduction for psychiatric hospitalizations. CAPS services have institutional limits due to the model adopted of direct public administration and local government

  5. Summary of Dissolved Concentration Limits

    Energy Technology Data Exchange (ETDEWEB)

    Yueting Chen

    2001-06-11

    According to the Technical Work Plan titled Technical Work Plan for Waste Form Degradation Process Model Report for SR (CRWMS M&O 2000a), the purpose of this study is to perform abstractions on solubility limits of radioactive elements based on the process-level information and thermodynamic databases provided by Natural Environment Program Operations (NEPO) and Waste Package Operations (WPO). The scope of this analysis is to produce solubility limits as functions, distributions, or constants for all transported radioactive elements identified by the Performance Assessment Operations (PAO) radioisotope screening. Results from an expert elicitation for solubility limits of most radioactive elements were used in the previous Total System Performance Assessments (TSPAs). However, the elicitation conducted in 1993 does not meet the criteria set forth by the U.S. Nuclear Regulatory Commission (NRC) due to lack of documentation and traceability (Kotra et al. 1996, Section 3). Therefore, at the Waste Form Abstraction Workshop held on February 2-4, 1999, at Albuquerque, New Mexico, the Yucca Mountain Site Characterization Project (YMP) decided to develop geochemical models to study solubility for the proposed Monitored Geologic Repository. WPO/NEPO is to develop process-level solubility models, including review and compilation of relevant thermodynamic data. PAO's responsibility is to perform abstractions based on the process models and chemical conditions and to produce solubility distributions or response surfaces applicable to the proposed repository. The results of this analysis and conceptual model will feed the performance assessment for Total System Performance Assessment--Site Recommendation (TSPA-SR) and Total System Performance Assessment--License Application (TSPA-LA), and to the Waste Form Degradation Process Model Report section on concentration limits.

  6. Limitation and buffering performance analysis of swaying fender in float-over installation for offshore platform%海洋平台浮托安装中横荡护舷限位和缓冲性能分析

    Institute of Scientific and Technical Information of China (English)

    刘利壮; 王树青; 潘沈浩

    2016-01-01

    浮托安装法,是相对于传统吊装法的一种新型海洋平台安装方法,具有起重能力大、作业周期短、安装费用低、适用范围广、操作安全方便等优点,解决了海上大型平台组块的安装问题。为了研究横荡护舷对浮托安装的影响,首先对海洋平台浮托安装中的护舷装置进行了介绍,然后针对某工程实例应用AQWA软件进行了数值模拟,并进行了模型验证。从时域方面对就位状态下的浮托模型进行了耦合动力分析,研究了横荡护舷参数对驳船运动和撞击力的影响规律。研究表明,横荡护舷可以有效地减小驳船运动和撞击力,其限位和缓冲作用与护舷尺寸及护舷刚度均有关。研究结果可为实际浮托安装工程提供重要的参考。%Float-over is a new offshore installation method compared with traditional lifting methods, with the advantages of large lifting capacity, short operation time, low installation cost, wide application, safe and convenient operation, etc. It solves the problem of installation of large offshore platform. In order to study the influence of the swaying fender on the float-over, the fender devices of float-over installation for offshore platform are first introduced. Then, a float-over installation numerical simulation is demonstrated using AQWA based on a practical engineering installation, and the model test results are used to verify the numerical results. The coupled dynamic analysis of float-over model is performed in the time domain under docking situation. Particular attention is paid to the impact of different swaying fenders parameters on the motion and impact force of barge. The results show that the swaying fender can reduce the motion and impact force of barge effectively, and its limitation and buffering performance are related to its size and stiffness. The research results can provide an important reference value for practical float-over projects.

  7. VT Limited Access Highways

    Data.gov (United States)

    Vermont Center for Geographic Information — A limited-access road, known by various terms worldwide, including limited-access highway, dual carriageway, expressway, and partial controlled access highway, is a...

  8. Robust test limits

    NARCIS (Netherlands)

    Albers, Willem/Wim; Kallenberg, W.C.M.; Otten, G.D.

    1997-01-01

    Because of inaccuracies of the measurement process inspection of manufactured parts requires test limits which are more strict than the given specification limits. Test limits derived under the assumption of normality for product characteristics turn out to violate the prescribed bound on the

  9. Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases

    Energy Technology Data Exchange (ETDEWEB)

    Laughlin, J. D.; Nwachukwu, J. C.; Figuera-Losada, M.; Cherry, L.; Nettles, K. W.; LoGrasso, P. V.

    2012-12-05

    c-Jun N-terminal (JNK) family kinases have a common peptide-docking site used by upstream activating kinases, substrates, scaffold proteins, and phosphatases, where the ensemble of bound proteins determines signaling output. Although there are many JNK structures, little is known about mechanisms of allosteric regulation between the catalytic and peptide-binding sites, and the activation loop, whose phosphorylation is required for catalytic activity. Here, we compare three structures of unliganded JNK3 bound to different peptides. These were compared as a class to structures that differ in binding of peptide, small molecule ligand, or conformation of the kinase activation loop. Peptide binding induced an inhibitory interlobe conformer that was reversed by alterations in the activation loop. Structure class analysis revealed the subtle structural mechanisms for allosteric signaling between the peptide-binding site and activation loop. Biochemical data from isothermal calorimetry, fluorescence energy transfer, and enzyme inhibition demonstrated affinity differences among the three peptides that were consistent with structural observations.

  10. Allostery in trypsin-like proteases suggests new therapeutic strategies.

    Science.gov (United States)

    Gohara, David W; Di Cera, Enrico

    2011-11-01

    Trypsin-like proteases (TLPs) are a large family of enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis and immunity. A current paradigm posits that the irreversible transition from an inactive zymogen to the active protease form enables productive interaction with substrate and catalysis. Analysis of the entire structural database reveals two distinct conformations of the active site: one fully accessible to substrate (E) and the other occluded by the collapse of a specific segment (E*). The allosteric E*-E equilibrium provides a reversible mechanism for activity and regulation in addition to the irreversible zymogen to protease conversion and points to new therapeutic strategies aimed at inhibiting or activating the enzyme. In this review, we discuss relevant examples, with emphasis on the rational engineering of anticoagulant thrombin mutants.

  11. CYP2E1 Metabolism of Styrene Involves Allostery

    OpenAIRE

    2012-01-01

    We are the first to report allosterism during styrene oxidation by recombinant CYP2E1 and human liver microsomes. At low styrene concentrations, oxidation is inefficient because of weak binding to CYP2E1 (Ks = 830 μM). A second styrene molecule then binds CYP2E1 with higher affinity (Kss = 110 μM) and significantly improves oxidation to achieve a kcat of 6.3 nmol · min−1 · nmol CYP2E1−1. The transition between these metabolic cycles coincides with reported styrene concentrations in blood from...

  12. CYP2E1 Metabolism of Styrene Involves Allostery

    Science.gov (United States)

    Hartman, Jessica H.; Boysen, Gunnar

    2012-01-01

    We are the first to report allosterism during styrene oxidation by recombinant CYP2E1 and human liver microsomes. At low styrene concentrations, oxidation is inefficient because of weak binding to CYP2E1 (Ks = 830 μM). A second styrene molecule then binds CYP2E1 with higher affinity (Kss = 110 μM) and significantly improves oxidation to achieve a kcat of 6.3 nmol · min−1 · nmol CYP2E1−1. The transition between these metabolic cycles coincides with reported styrene concentrations in blood from exposed workers; thus, this CYP2E1 mechanism may be relevant in vivo. Scaled modeling of the in vitro-positive allosteric mechanism for styrene metabolism to its in vivo clearance led to significant deviations from the traditional model based on Michaelis-Menten kinetics. Low styrene levels were notably much less toxic than generally assumed. We interrogated the allosteric mechanism using the CYP2E1-specific inhibitor and drug 4-methylpyrazole, which we have shown binds two CYP2E1 sites. From the current studies, styrene was a positive allosteric effector on 4-methylpyrazole binding, based on a 10-fold increase in 4-methylpyrazole binding affinity from Ki 0.51 to Ksi 0.043 μM. The inhibitor was a negative allosteric effector on styrene oxidation, because kcat decreased 6-fold to 0.98 nmol · min−1 · nmol CYP2E1−1. Consequently, mixtures of styrene and other molecules can induce allosteric effects on binding and metabolism by CYP2E1 and thus mitigate the efficiency of their metabolism and corresponding effects on human health. Taken together, our elucidation of mechanisms for these allosteric reactions provides a powerful tool for further investigating the complexities of CYP2E1 metabolism of drugs and pollutants. PMID:22807108

  13. Competition and allostery govern substrate selectivity of cyclooxygenase-2

    Science.gov (United States)

    Mitchener, Michelle M.; Hermanson, Daniel J.; Shockley, Erin M.; Brown, H. Alex; Lindsley, Craig W.; Reese, Jeff; Rouzer, Carol A.; Lopez, Carlos F.; Marnett, Lawrence J.

    2015-01-01

    Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidonoylglycerol (2-AG), to prostaglandins (PGs) and prostaglandin glyceryl esters (PG-Gs), respectively. Although the efficiency of oxygenation of these substrates by COX-2 in vitro is similar, cellular biosynthesis of PGs far exceeds that of PG-Gs. Evidence that the COX enzymes are functional heterodimers suggests that competitive interaction of AA and 2-AG at the allosteric site of COX-2 might result in differential regulation of the oxygenation of the two substrates when both are present. Modulation of AA levels in RAW264.7 macrophages uncovered an inverse correlation between cellular AA levels and PG-G biosynthesis. In vitro kinetic analysis using purified protein demonstrated that the inhibition of 2-AG oxygenation by high concentrations of AA far exceeded the inhibition of AA oxygenation by high concentrations of 2-AG. An unbiased systems-based mechanistic model of the kinetic data revealed that binding of AA or 2-AG at the allosteric site of COX-2 results in a decreased catalytic efficiency of the enzyme toward 2-AG, whereas 2-AG binding at the allosteric site increases COX-2’s efficiency toward AA. The results suggest that substrates interact with COX-2 via multiple potential complexes involving binding to both the catalytic and allosteric sites. Competition between AA and 2-AG for these sites, combined with differential allosteric modulation, gives rise to a complex interplay between the substrates, leading to preferential oxygenation of AA. PMID:26392530

  14. Allostery and conformational dynamics in cAMP-binding acyltransferases.

    Science.gov (United States)

    Podobnik, Marjetka; Siddiqui, Nida; Rebolj, Katja; Nambi, Subhalaxmi; Merzel, Franci; Visweswariah, Sandhya S

    2014-06-06

    Mycobacteria harbor unique proteins that regulate protein lysine acylation in a cAMP-regulated manner. These lysine acyltransferases from Mycobacterium smegmatis (KATms) and Mycobacterium tuberculosis (KATmt) show distinctive biochemical properties in terms of cAMP binding affinity to the N-terminal cyclic nucleotide binding domain and allosteric activation of the C-terminal acyltransferase domain. Here we provide evidence for structural features in KATms that account for high affinity cAMP binding and elevated acyltransferase activity in the absence of cAMP. Structure-guided mutational analysis converted KATms from a cAMP-regulated to a cAMP-dependent acyltransferase and identified a unique asparagine residue in the acyltransferase domain of KATms that assists in the enzymatic reaction in the absence of a highly conserved glutamate residue seen in Gcn5-related N-acetyltransferase-like acyltransferases. Thus, we have identified mechanisms by which properties of similar proteins have diverged in two species of mycobacteria by modifications in amino acid sequence, which can dramatically alter the abundance of conformational states adopted by a protein.

  15. Atomic resolution probe for allostery in the regulatory thin filament

    Science.gov (United States)

    Williams, Michael R.; Lehman, Sarah J.; Tardiff, Jil C.; Schwartz, Steven D.

    2016-01-01

    Calcium binding and dissociation within the cardiac thin filament (CTF) is a fundamental regulator of normal contraction and relaxation. Although the disruption of this complex, allosterically mediated process has long been implicated in human disease, the precise atomic-level mechanisms remain opaque, greatly hampering the development of novel targeted therapies. To address this question, we used a fully atomistic CTF model to test both Ca2+ binding strength and the energy required to remove Ca2+ from the N-lobe binding site in WT and mutant troponin complexes that have been linked to genetic cardiomyopathies. This computational approach is combined with measurements of in vitro Ca2+ dissociation rates in fully reconstituted WT and cardiac troponin T R92L and R92W thin filaments. These human disease mutations represent known substitutions at the same residue, reside at a significant distance from the calcium binding site in cardiac troponin C, and do not affect either the binding pocket affinity or EF-hand structure of the binding domain. Both have been shown to have significantly different effects on cardiac function in vivo. We now show that these mutations independently alter the interaction between the Ca2+ ion and cardiac troponin I subunit. This interaction is a previously unidentified mechanism, in which mutations in one protein of a complex indirectly affect a third via structural and dynamic changes in a second to yield a pathogenic change in thin filament function that results in mutation-specific disease states. We can now provide atom-level insight that is potentially highly actionable in drug design. PMID:26957598

  16. Passive immitance limiters

    Directory of Open Access Journals (Sweden)

    Filinyuk N. A.

    2015-06-01

    Full Text Available The paper presents quadripole R, L, C immittance limiters, in which output immittance to the certain value depends on the input immittance. A classification of immittance limiters is given. Basic parameters are considered: low and high levels of output immittance limiters; low and high values of input immittance, corresponding to low and high levels of limitation, accordingly; range of possible values of output immittance; steepness of immittance limiters; time of wearing-out (or delay; high and low cutoff frequencies; central working frequency; frequency band; relative range of working frequencies; non-linearity coefficient. The authors have designed passive R-, L-, C-limiters with possibility of limitation from above and from below. The influence of the input parasitic immittances on the immittance transfer characteristic is evaluated. In most cases parasite immittance does not influence the considered devices, including R-limiters «from above» with the input quality factor of QR(Linp=0,1…0,2 and L-limiters «from above» with high-quality input circuits with QL(Rinp>2. The analysis also shows that high-qualitiy circuits with QN(RinpN>3 should be used in C-limiters with input parasitic immittances, while at parasitic immittance of the limiting element low-quality circuits with QN(RiN>0,2 should be selected.

  17. Limitations on quantum key repeaters.

    Science.gov (United States)

    Bäuml, Stefan; Christandl, Matthias; Horodecki, Karol; Winter, Andreas

    2015-04-23

    A major application of quantum communication is the distribution of entangled particles for use in quantum key distribution. Owing to noise in the communication line, quantum key distribution is, in practice, limited to a distance of a few hundred kilometres, and can only be extended to longer distances by use of a quantum repeater, a device that performs entanglement distillation and quantum teleportation. The existence of noisy entangled states that are undistillable but nevertheless useful for quantum key distribution raises the question of the feasibility of a quantum key repeater, which would work beyond the limits of entanglement distillation, hence possibly tolerating higher noise levels than existing protocols. Here we exhibit fundamental limits on such a device in the form of bounds on the rate at which it may extract secure key. As a consequence, we give examples of states suitable for quantum key distribution but unsuitable for the most general quantum key repeater protocol.

  18. Limitations to sharing entanglement

    CERN Document Server

    Kim, Jeong San; Sanders, Barry C

    2011-01-01

    We discuss limitations to sharing entanglement known as monogamy of entanglement. Our pedagogical approach commences with simple examples of limited entanglement sharing for pure three-qubit states and progresses to the more general case of mixed-state monogamy relations with multiple qudits.

  19. Limits to Inclusion

    Science.gov (United States)

    Hansen, Janne Hedegaard

    2012-01-01

    In this article, I will argue that a theoretical identification of the limit to inclusion is needed in the conceptual identification of inclusion. On the one hand, inclusion is formulated as a vision that is, in principle, limitless. On the other hand, there seems to be an agreement that inclusion has a limit in the pedagogical practice. However,…

  20. Limits to Inclusion

    Science.gov (United States)

    Hansen, Janne Hedegaard

    2012-01-01

    In this article, I will argue that a theoretical identification of the limit to inclusion is needed in the conceptual identification of inclusion. On the one hand, inclusion is formulated as a vision that is, in principle, limitless. On the other hand, there seems to be an agreement that inclusion has a limit in the pedagogical practice. However,…

  1. Numerical Limit Analysis:

    DEFF Research Database (Denmark)

    Damkilde, Lars

    2007-01-01

    Limit State analysis has a long history and many prominent researchers have contributed. The theoretical foundation is based on the upper- and lower-bound theorems which give a very comprehensive and elegant formulation on complicated physical problems. In the pre-computer age Limit State analysis...

  2. Numerical Limit Analysis:

    DEFF Research Database (Denmark)

    Damkilde, Lars

    2007-01-01

    Limit State analysis has a long history and many prominent researchers have contributed. The theoretical foundation is based on the upper- and lower-bound theorems which give a very comprehensive and elegant formulation on complicated physical problems. In the pre-computer age Limit State analysis...... also enabled engineers to solve practical problems within reinforced concrete, steel structures and geotechnics....

  3. Modeling Complex Time Limits

    Directory of Open Access Journals (Sweden)

    Oleg Svatos

    2013-01-01

    Full Text Available In this paper we analyze complexity of time limits we can find especially in regulated processes of public administration. First we review the most popular process modeling languages. There is defined an example scenario based on the current Czech legislature which is then captured in discussed process modeling languages. Analysis shows that the contemporary process modeling languages support capturing of the time limit only partially. This causes troubles to analysts and unnecessary complexity of the models. Upon unsatisfying results of the contemporary process modeling languages we analyze the complexity of the time limits in greater detail and outline lifecycles of a time limit using the multiple dynamic generalizations pattern. As an alternative to the popular process modeling languages there is presented PSD process modeling language, which supports the defined lifecycles of a time limit natively and therefore allows keeping the models simple and easy to understand.

  4. The Hugoniot Elastic Limit Decay Limit

    Science.gov (United States)

    Billingsley, J. P.

    1997-07-01

    The Hugoniot Elastic Limit(HEL) precursor decay in shock loaded solids has been the subject of considerable experimental and theoretical investigation. Comparative evidence is presented to show that the elastic precursor wave particle velocity, UPHEL, for certain materials decays asymptotically with propagation distance to the DeBroglie velocity, V1, level. This is demonstrated for the following materials: iron, aluminum alloy 6061-T6, plexiglas(PMMA), nickel alloy(MAR-M200), and lithium flouride(LiF). The DeBroglie velocity, V1, equals h/2md, where h is Planck's Constant, m is the mass of one atom, and d is the closest distance between atoms. Thus a relationship has been established between a microscopically derived velocity, V1, and a macroscopically observed velocity, UPHEL.

  5. ACA Federal Upper Limits

    Data.gov (United States)

    U.S. Department of Health & Human Services — Affordable Care Act Federal Upper Limits (FUL) based on the weighted average of the most recently reported monthly average manufacturer price (AMP) for...

  6. HUD Program Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — Income limits used to determine the income eligibility of applicants for assistance under three programs authorized by the National Housing Act. These programs are...

  7. Limit experiments of GARCH

    CERN Document Server

    Buchmann, Boris; 10.3150/10-BEJ328

    2012-01-01

    GARCH is one of the most prominent nonlinear time series models, both widely applied and thoroughly studied. Recently, it has been shown that the COGARCH model (which was introduced a few years ago by Kl\\"{u}ppelberg, Lindner and Maller) and Nelson's diffusion limit are the only functional continuous-time limits of GARCH in distribution. In contrast to Nelson's diffusion limit, COGARCH reproduces most of the stylized facts of financial time series. Since it has been proven that Nelson's diffusion is not asymptotically equivalent to GARCH in deficiency, in the present paper, we investigate the relation between GARCH and COGARCH in Le Cam's framework of statistical equivalence. We show that GARCH converges generically to COGARCH, even in deficiency, provided that the volatility processes are observed. Hence, from a theoretical point of view, COGARCH can indeed be considered as a continuous-time equivalent to GARCH. Otherwise, when the observations are incomplete, GARCH still has a limiting experiment, which we ...

  8. Limited Denial of Participation

    Data.gov (United States)

    Department of Housing and Urban Development — A Limited Denial of Participation (LDP) is an action taken by a HUD Field Office or the Deputy Assistant Secretary for Single Family (DASSF) or Multifamily (DASMF)...

  9. HOME Rent Limits

    Data.gov (United States)

    Department of Housing and Urban Development — In accordance with 24 CFR Part 92.252, HUD provides maximum HOME rent limits. The maximum HOME rents are the lesser of: The fair market rent for existing housing for...

  10. PLT rotating pumped limiter

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, S.A.; Budny, R.V.; Corso, V.; Boychuck, J.; Grisham, L.; Heifetz, D.; Hosea, J.; Luyber, S.; Loprest, P.; Manos, D.

    1984-07-01

    A limiter with a specially contoured front face and the ability to rotate during tokamak discharges has been installed in a PLT pump duct. These features have been selected to handle the unique particle removal and heat load requirements of ICRF heating and lower-hybrid current-drive experiments. The limiter has been conditioned and commissioned in an ion-beam test stand by irradiation with 1 MW power, 200 ms duration beams of 40 keV hydrogen ions. Operation in PLT during ohmic discharges has proven the ability of the limiter to reduce localized heating caused by energetic electron bombardment and to remove about 2% of the ions lost to the PLT walls and limiters.

  11. Limited Income and Resources

    Data.gov (United States)

    U.S. Department of Health & Human Services — Information for those with limited income and resources (those who may qualify for or already have the Low Income Subsidy to lower their prescription drug coverage...

  12. Limited Angle Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ho Kyung; Cho, Min Kook; Kim, Seong Sik [Pusan National University, Busan (Korea, Republic of)

    2007-07-01

    In computed tomography (CT), many situations are restricted to obtain enough number of projections or views to avoid artifacts such as streaking and geometrical distortion in the reconstructed images. Speed of motion of an object to be imaged can limit the number of views. Cardiovascular imaging is a representative example. Size of an object can also limit the complete traverse motion or geometrical complexity can obscure to be imaged at certain range of angles. These situations are frequently met in industrial nondestructive testing and evaluation. Dental CT also suffers from similar situation because cervical spine causes less x-ray penetration from some directions such that the available information is not sufficient for standard reconstruction algorithms. The limited angle tomography is now greatly paid attention as a new genre in medical and industrial imaging, popularly known as digital tomosynthesis. In this study, we introduce a modified filtered backprojection method in limited angle tomography and demonstrate its application for the dental imaging.

  13. SIS - Annual Catch Limit

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Annual Catch Limit (ACL) dataset within the Species Information System (SIS) contains information and data related to management reference points and catch data.

  14. Altruism and Reproductive Limitations

    Directory of Open Access Journals (Sweden)

    Carey J. Fitzgerald

    2009-04-01

    Full Text Available We examined how different types of reproductive limitations — functional (schizoid personality disorder and schizophrenia, physical (malnutrition, and sexual (bisexuality and homosexuality — influenced altruistic intentions toward hypothetical target individuals of differing degrees of relatedness (r = 0, .25, and .50. Participants were 312 undergraduate students who completed a questionnaire on altruism toward hypothetical friends, half-siblings, and siblings with these different types of reproductive limitations. Genetic relatedness and reproductive limitations did not influence altruistic decision-making when the cost of altruism was low but did as the cost of altruism increased, with participants being more likely to help a sibling over a half-sibling and a half-sibling over a friend. Participants also indicated they were more likely to help a healthy (control person over people with a reproductive limitation. Of the three types of reproductive limitations, functional limitations had the strongest effect on altruistic decision-making, indicating that people were less likely to help those who exhibit abnormal social behavior.

  15. Aluminum honeycomb impact limiter study

    Energy Technology Data Exchange (ETDEWEB)

    Yaksh, M.C.; Thompson, T.C. (Nuclear Assurance Corp., Norcross, GA (United States)); Nickell, R.E. (Applied Science and Technology, Inc., Poway, CA (United States))

    1991-07-01

    Design requirements for a cask transporting radioactive materials must include the condition of the 30-foot free fall of the cask onto an unyielding surface. To reduce the deceleration loads to a tolerable level for all the components of the cask, a component (impact limiter) is designed to absorb the kinetic energy. The material, shape, and method of attachment of the impact limiter to the cask body comprises the design of the impact limiter. The impact limiter material of interest is honeycomb aluminum, and the particular design examined was for the NAC Legal Weight Truck cask (NAC-LWT) for spent fuel from light water reactors. The NAC-LWT has a design weight of 52,000 pounds, and it has a nominal length of 200 inches. The report describes the numerical calculations embodied in the FADE program to determine the accelerations and crush strain resulting from an arbitrary height and angle of orientation. Since the program serves as a design tool, static tests are performed to assess the effect of the shell containing the honeycomb aluminum. The static tests and their results are contained in the study. The static tests are used to demonstrate for licensing purposes the level of accelerations imposed on the cask during a 30-foot drop. 3 refs., 41 figs., 15 tabs.

  16. 32 CFR 169a.19 - Study limits.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Study limits. 169a.19 Section 169a.19 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.19 Study limits. No DoD funds shall be available to perform any...

  17. Fundamental Limits of Cooperation

    CERN Document Server

    Lozano, Angel; Andrews, Jeffrey G

    2012-01-01

    Cooperation is viewed as a key ingredient for interference management in wireless systems. This paper shows that cooperation has fundamental limitations. The main result is that even full cooperation between transmitters cannot in general change an interference-limited network to a noise-limited network. The key idea is that there exists a spectral efficiency upper bound that is independent of the transmit power. First, a spectral efficiency upper bound is established for systems that rely on pilot-assisted channel estimation; in this framework, cooperation is shown to be possible only within clusters of limited size, which are subject to out-of-cluster interference whose power scales with that of the in-cluster signals. Second, an upper bound is also shown to exist when cooperation is through noncoherent communication; thus, the spectral efficiency limitation is not a by-product of the reliance on pilot-assisted channel estimation. Consequently, existing literature that routinely assumes the high-power spect...

  18. The quantum geometric limit

    CERN Document Server

    Lloyd, Seth

    2012-01-01

    This letter analyzes the limits that quantum mechanics imposes on the accuracy to which spacetime geometry can be measured. By applying the fundamental physical bounds to measurement accuracy to ensembles of clocks and signals moving in curved spacetime -- e.g., the global positioning system -- I derive a covariant version of the quantum geometric limit: the total number of ticks of clocks and clicks of detectors that can be contained in a four volume of spacetime of radius r and temporal extent t is less than or equal to rt/\\pi x_P t_P, where x_P, t_P are the Planck length and time. The quantum geometric limit bounds the number of events or `ops' that can take place in a four-volume of spacetime: each event is associated with a Planck-scale area. Conversely, I show that if each quantum event is associated with such an area, then Einstein's equations must hold. The quantum geometric limit is consistent with and complementary to the holographic bound which limits the number of bits that can exist within a spat...

  19. Swimming as a limit cycle

    CERN Document Server

    Jacobs, Henry O

    2012-01-01

    Steady swimming can be characterized as both periodic and stable. These characteristics are the very definition of limit cycles, and so we ask "Can we view swimming as a limit cycle?" In this paper we will find that the answer is "yes". We will define a class of dissipative systems which correspond to the passive dynamics of a body immersed in a Navier-Stokes fluid (i.e. the dynamics of a dead fish). Upon performing reduction by symmetry we will find a hyperbolically stable fixed point which corresponds to the stability of a dead fish in stagnant water. Given a periodic force on the shape of the body we will invoke the persistence theorem to assert the existence of a loop which approximately satisfies the exact equations of motion. If we lift this loop with a phase reconstruction formula we will find that the lifted loops are not loops, but stable trajectories which represent regular periodic motion reminiscent of swimming.

  20. Load limiting parachute inflation control

    Energy Technology Data Exchange (ETDEWEB)

    Redmond, J.; Hinnerichs, T.; Parker, G.

    1994-01-01

    Excessive deceleration forces experienced during high speed deployment of parachute systems can cause damage to the payload and the canopy fabric. Conventional reefing lines offer limited relief by temporarily restricting canopy inflation and limiting the peak deceleration load. However, the open-loop control provided by existing reefing devices restrict their use to a specific set of deployment conditions. In this paper, the sensing, processing, and actuation that are characteristic of adaptive structures form the basis of three concepts for active control of parachute inflation. These active control concepts are incorporated into a computer simulation of parachute inflation. Initial investigations indicate that these concepts promise enhanced performance as compared to conventional techniques for a nominal release. Furthermore, the ability of each controller to adapt to off-nominal release conditions is examined.

  1. FANCM limits meiotic crossovers.

    Science.gov (United States)

    Crismani, Wayne; Girard, Chloé; Froger, Nicole; Pradillo, Mónica; Santos, Juan Luis; Chelysheva, Liudmila; Copenhaver, Gregory P; Horlow, Christine; Mercier, Raphaël

    2012-06-22

    The number of meiotic crossovers (COs) is tightly regulated within a narrow range, despite a large excess of molecular precursors. The factors that limit COs remain largely unknown. Here, using a genetic screen in Arabidopsis thaliana, we identified the highly conserved FANCM helicase, which is required for genome stability in humans and yeasts, as a major factor limiting meiotic CO formation. The fancm mutant has a threefold-increased CO frequency as compared to the wild type. These extra COs arise not from the pathway that accounts for most of the COs in wild type, but from an alternate, normally minor pathway. Thus, FANCM is a key factor imposing an upper limit on the number of meiotic COs, and its manipulation holds much promise for plant breeding.

  2. Quantum-Limited Spectroscopy

    CERN Document Server

    Truong, Gar-Wing; May, Eric F; Stace, Thomas M; Luiten, Andre N

    2015-01-01

    Spectroscopy has an illustrious history delivering serendipitous discoveries and providing a stringent testbed for new physical predictions, including applications from trace materials detection, to understanding the atmospheres of stars and planets, and even constraining cosmological models. Reaching fundamental-noise limits permits optimal extraction of spectroscopic information from an absorption measurement. Here we demonstrate a quantum-limited spectrometer that delivers high-precision measurements of the absorption lineshape. These measurements yield a ten-fold improvement in the accuracy of the excited-state (6P$_{1/2}$) hyperfine splitting in Cs, and reveals a breakdown in the well-known Voigt spectral profile. We develop a theoretical model that accounts for this breakdown, explaining the observations to within the shot-noise limit. Our model enables us to infer the thermal velocity-dispersion of the Cs vapour with an uncertainty of 35ppm within an hour. This allows us to determine a value for Boltzm...

  3. Limits of Lubrication in

    DEFF Research Database (Denmark)

    Olsson, David Dam

    by strategic surfaces in comparison to normal stainless steel surfaces implying a larger extent of bi-axial stretching. Numerical simulations have been applied in order to evaluate limits of lubrication in the simulative strip reduction based on predictions of critical parameters appearing in terms...... of temperature and contact pressure. The numerical models have been calibrated regarding friction and thermal contact resistance based on experimental results from actual testing conditions. It has been found that predictions of limits of lubrication are possible by numerical means and that the FE...

  4. The Limits of CD Metrology

    Science.gov (United States)

    Rice, Bryan J.; Cao, Heidi; Grumski, Michael; Roberts, Jeanette

    2005-09-01

    One of the many technology decisions facing the semiconductor industry for the 32 nm node (and beyond) is the selection of the best critical dimension (CD) metrology equipment to meet the needs of process equipment suppliers and semiconductor manufacturers. Over the past three years Intel ® has fabricated a variety of test structures and performed a number of technology evaluations aimed at determining the limits of today's CD metrology. In this paper we discuss the capability of those technologies to measure structures having dimensions representative of the 45 nm, 32 nm, and 22 nm nodes.

  5. Limits to responsible innovation

    NARCIS (Netherlands)

    de Hoop, E.; Pols, Auke; Romijn, Henny

    2016-01-01

    Responsible Innovation (RI) is a young field of research that has nevertheless had remarkable successes in dissemination within academic and political circles. However, there is relatively little awareness of its limits, blind spots and situations in which it cannot be used for actual innovation tra

  6. The Limits of Laughter.

    Science.gov (United States)

    Mindess, Harvey

    1983-01-01

    Three incidents which elucidate the limits of laughter are described. Most persons enjoy humor as comic relief, but when humor strikes a blow at something they hold dear, they find it very hard to laugh. People are upset by an irreverent attitude toward things they hold in esteem. (RM)

  7. Pushing the Photon Limit

    NARCIS (Netherlands)

    Wientjes, Emilie; Renger, Jan; Cogdell, Richard; Hulst, van Niek F.

    2016-01-01

    Nanoantennas are well-known for their effective role in fluorescence enhancement, both in excitation and emission. Enhancements of 3-4 orders of magnitude have been reported. Yet in practice, the photon emission is limited by saturation due to the time that a molecule spends in singlet and especi

  8. Tightening Home Purchase Limits

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    More Chinese cities will limit home purchase to cool the red-hot real estate market In June 2011,the average house price in 100 Chinese cities was 8,856 yuan ($1,373)per square meter.Of these cities,house prices in 75 of them increased

  9. Limitation of Auditors' Liability

    DEFF Research Database (Denmark)

    Werlauff, Erik; Foged-Ladefoged, Lise Kolding

    2014-01-01

    The article examines the question of whether rules on the limitation of auditors’ liability within the perspective of EU law are needed, and if so, which rules can provide an appropriate balance between the potential injured party’s interests and those of the auditing sector, including with respect...

  10. Limits of Software Reuse

    NARCIS (Netherlands)

    Holenderski, L.

    2006-01-01

    Software reuse is considered one of the main techniques to increasesoftware productivity. We present two simple mathematical argumentsthat show some theoretical limits of reuse. It turns out that the increase of productivity due to internal reuse is at most linear, farfrom the needed exponential gr

  11. Phenotypic variation in metabolism and morphology correlating with animal swimming activity in the wild: relevance for the OCLTT (oxygen- and capacity-limitation of thermal tolerance), allocation and performance models

    DEFF Research Database (Denmark)

    Baktoft, Henrik; Jacobsen, Lene; Skov, Christian

    2016-01-01

    individual in situ activity levels. Metabolic rates were measured using intermittent flow respirometry, whereas the activity assay involved high-resolution telemetry providing positions every 30 s over 12 days. We found no correlation between individual metabolic traits and activity, whereas individual...... fineness ratio correlated with activity. Independent of body length, and consistent with physics theory, slender fish maintained faster mean and maximal swimming speeds, but this variation did not result in a larger area (in square metres) explored per 24 h. Testing assumptions and predictions of recent......H in the aquatic environment. The hypothesis remains controversial, however, and has been questioned in several studies. A positive relationship between aerobic metabolic scope and animal activity would be consistent with the OCLTT but has rarely been tested. Moreover, the performance model and the allocation...

  12. Petite motorisation et exploitations maraîchères de taille limitée du Sahel tunisien Partie 2: Evaluation sur le terrain des performances et des coûts de préparation du sol

    Directory of Open Access Journals (Sweden)

    Chehaibi, S.

    2003-01-01

    Full Text Available Low Power Mechanisation and Small-scale Vegetable Production in the Tunisian Sahel Region. Part 2: On the Field Evaluation of Performances and of Soil Preparation Costs. In this study, it was investigated to what extent low power mechanisation could be introduced in vegetable production in the Tunisian Sahel region by evaluating its performance (labour input and field efficiency by means of field experiments in which different traction equipment was used for carrying out several cultivation operations. Furthermore, costs per unit area for soil preparation in both sandy clay and clayish sand were calculated for four different power classes and for small fields. The results showed that two wheel tractors had a real labour input for scuffling between plant rows ranging from 11.3 h/ha to 18.7 h/ha. These inputs ranged from 5.5 h/ha to 6.7 h/ha for tied crops. For mowing, the two wheel tractor had labour inputs of 17.3 and 14.2 h/ha for the first and the second cut, respectively, while for potato digging, the first and the second passage of secondary tillage these values were 11.5, 14.3 and 10.4 h/ha, respectively. Superficial soil preparation by means of a four wheel tractor gave rise to values between 2.7 and 3.5 h/ha. With respect to the cost estimation for soil preparation, the lowest costs were obtained by means of the low power mechanisation. Similar conclusions were drawn for the field efficiencies for the operations investigated. In general, these efficiencies were above 70%.

  13. 基于有限反馈的非可信中继系统的物理层安全性能分析%Performance Analysis of Physical Layer Security of Untrusted Relay System Based on Limited Feedback

    Institute of Scientific and Technical Information of China (English)

    吴亚峰; 赵睿; 贺玉成; 谢维波

    2015-01-01

    在基于有限反馈获得部分信道状态信息的条件下,研究了放大转发非可信中继系统的物理层安全传输技术。通过目的节点发送人工噪声干扰信息,使系统获得了正安全容量。推导了安全中断概率和传输中断概率的闭合表达式,分析了反馈比特数对系统安全性和可靠性的影响,进而提出了能同时兼顾系统安全性和可靠性的最优反馈比特数的自适应选择方案。%Under the condition of partial channel state information that is obtained from limited feedback,a physical layer se-curity transmission technique is investigated for amplify-and-forward untrusted relay systems,where the positive secrecy capacity is obtained through the artificial noise interference information transmitted by the destination node.Closedform expressions for security outage probability and transmission outage probability are derived,and the impacts of the number of feedback bits on security and reliability are analyzed.Furthermore,an adaptive selection scheme for the optimal number of feedback bits is proposed in order to si-multaneously satisfy both required security and reliability.

  14. Optimal Disturbance Accommodation with Limited Model Information

    CERN Document Server

    Farokhi, F; Johansson, K H

    2011-01-01

    The design of optimal dynamic disturbance-accommodation controller with limited model information is considered. We adapt the family of limited model information control design strategies, defined earlier by the authors, to handle dynamic-controllers. This family of limited model information design strategies construct subcontrollers distributively by accessing only local plant model information. The closed-loop performance of the dynamic-controllers that they can produce are studied using a performance metric called the competitive ratio which is the worst case ratio of the cost a control design strategy to the cost of the optimal control design with full model information.

  15. The applicability and limitations of the geochemical models and tools used in simulating radionuclide behaviour in natural waters. Lessons learned from the Blind Predictive Modelling exercises performed in conjunction with Natural Analogue studies

    Energy Technology Data Exchange (ETDEWEB)

    Bruno, J.; Duro, L.; Grive, M. [QuantiSci SL, Parc Tecnologic del Valles (Spain)

    2001-07-01

    One of the key applications of Natural Analogue studies to the Performance Assessment (PA) of nuclear waste disposal has been the possibility to test the geochemical models and tools to be used in describing the migration of radionuclides in a future radioactive waste repository system. To this end, several geochemical modelling testing exercises (commonly denoted as Blind Predictive Modelling), have formed an integral part of Natural Analogue Studies over the last decade. Consequently, we thought that this is a timely occasion to make an evaluation of the experience gained and lessons learnt. We have reviewed, discussed and compared the results obtained from the Blind Prediction Modelling (BPM) exercises carried out within 7 Natural Analogue Studies: Oman, Pocos de Caldas, Cigar Lake, Maqarin, El Berrocal, Oklo and Palmottu. To make this comparison meaningful, we present the main geochemical characteristics of each site in order to highlight the most relevant mineralogical and hydrochemical differences. From the complete list of elements studied at all the investigated sites we have made a selection based on the relevance of a given element from a PA viewpoint and on the frequency this element has been included in the BPM exercises. The elements selected for discussion are: Sr, Ba, Sn, Pb, Se, Ni, Zn, REEs, Th and U. We have based our discussion on the results obtained from the speciation as well as solubility calculations. From the comparison of the results it is concluded that we can differentiate between three element categories: 1. Elements whose geochemical behaviour can be fairly well described by assuming solubility control exerted by pure solid phases of the given element (i.e. Th, U under reducing conditions and U in some sites under oxidising conditions); 2. Elements for which the association to major geochemical components of the system must be considered in order to explain their concentrations in groundwaters (i.e. Sr, Ba, Zn, Se, REEs and U under

  16. HEDIS Limited Data Set

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Healthcare Effectiveness Data and Information Set (HEDIS) is a tool used by more than 90 percent of Americas health plans to measure performance on important...

  17. Age Limit of Pediatrics.

    Science.gov (United States)

    Hardin, Amy Peykoff; Hackell, Jesse M

    2017-09-01

    Pediatrics is a multifaceted specialty that encompasses children's physical, psychosocial, developmental, and mental health. Pediatric care may begin periconceptionally and continues through gestation, infancy, childhood, adolescence, and young adulthood. Although adolescence and young adulthood are recognizable phases of life, an upper age limit is not easily demarcated and varies depending on the individual patient. The establishment of arbitrary age limits on pediatric care by health care providers should be discouraged. The decision to continue care with a pediatrician or pediatric medical or surgical subspecialist should be made solely by the patient (and family, when appropriate) and the physician and must take into account the physical and psychosocial needs of the patient and the abilities of the pediatric provider to meet these needs. Copyright © 2017 by the American Academy of Pediatrics.

  18. Limitations Of Infrared Thermography

    Science.gov (United States)

    Schott, John R.

    1983-03-01

    The state of the art of quantitative infrared thermography is addressed. We are asking more and more of thermography in the field of energy conservation. An energy and dollar conscious public wants to know how much heat is being lost and how much money can be saved by retrofit. Many mission oriented approaches have been developed to address these questions. However, many fundamental questions about how thermography works and how far its capabilities can be pushed have not been addressed. In addition, the theoretical and practical limits of doing benefit cost studies with thermography have not been seriously addressed. This paper discusses the limitations of the current technology and describes many unanswered but important questions facing the future use of thermography for quantitative heat loss analysis.

  19. Telescopic limiting magnitudes

    Science.gov (United States)

    Schaefer, Bradley E.

    1990-01-01

    The prediction of the magnitude of the faintest star visible through a telescope by a visual observer is a difficult problem in physiology. Many prediction formulas have been advanced over the years, but most do not even consider the magnification used. Here, the prediction algorithm problem is attacked with two complimentary approaches: (1) First, a theoretical algorithm was developed based on physiological data for the sensitivity of the eye. This algorithm also accounts for the transmission of the atmosphere and the telescope, the brightness of the sky, the color of the star, the age of the observer, the aperture, and the magnification. (2) Second, 314 observed values for the limiting magnitude were collected as a test of the formula. It is found that the formula does accurately predict the average observed limiting magnitudes under all conditions.

  20. Current limiter circuit system

    Energy Technology Data Exchange (ETDEWEB)

    Witcher, Joseph Brandon; Bredemann, Michael V.

    2017-09-05

    An apparatus comprising a steady state sensing circuit, a switching circuit, and a detection circuit. The steady state sensing circuit is connected to a first, a second and a third node. The first node is connected to a first device, the second node is connected to a second device, and the steady state sensing circuit causes a scaled current to flow at the third node. The scaled current is proportional to a voltage difference between the first and second node. The switching circuit limits an amount of current that flows between the first and second device. The detection circuit is connected to the third node and the switching circuit. The detection circuit monitors the scaled current at the third node and controls the switching circuit to limit the amount of the current that flows between the first and second device when the scaled current is greater than a desired level.

  1. Limiting Temperatures in Multifragmentation

    CERN Document Server

    Trautmann, W

    2008-01-01

    The systematic data set on isotopic effects in spectator fragmentation collected recently at the GSI laboratory permits the investigation of the N/Z dependence of the nuclear caloric curve which is of interest in several respects. In particular, new light is shed on the proposed interpretation of chemical breakup temperatures as a manifestation of the limiting temperatures predicted by the Hartree-Fock model. The obtained results are discussed within the general context of temperature measurements in multifragmentation reactions.

  2. Limits of Nuclear Stability

    CERN Document Server

    Nerlo-Pomorska, B; Kleban, M

    2003-01-01

    The modern version of the liquid-drop model (LSD) is compared with the macroscopic part of the binding energy evaluated within the Hartree-Fock- Bogoliubov procedure with the Gogny force and the relativistic mean field theory. The parameters of a liquid-drop like mass formula which approximate on the average the self-consistent results are compared with other models. The limits of nuclear stability predicted by these models are discussed.

  3. Limits of proton conductivity.

    Science.gov (United States)

    Kreuer, Klaus-Dieter; Wohlfarth, Andreas

    2012-10-15

    Parasitic current seems to be the cause for the "highest proton conductivity" of a material reported to date. Kreuer and Wohlfarth verify this hypothesis by measuring the conductivity of the same materials after preparing them in a different way. They further explain the limits of proton conductivity and comment on the problems of determining the conductivity of small objects (e.g., whiskers, see picture).

  4. Elastic limit of silicane.

    Science.gov (United States)

    Peng, Qing; De, Suvranu

    2014-10-21

    Silicane is a fully hydrogenated silicene-a counterpart of graphene-having promising applications in hydrogen storage with capacities larger than 6 wt%. Knowledge of its elastic limit is critical in its applications as well as tailoring its electronic properties by strain. Here we investigate the mechanical response of silicane to various strains using first-principles calculations based on density functional theory. We illustrate that non-linear elastic behavior is prominent in two-dimensional nanomaterials as opposed to bulk materials. The elastic limits defined by ultimate tensile strains are 0.22, 0.28, and 0.25 along armchair, zigzag, and biaxial directions, respectively, an increase of 29%, 33%, and 24% respectively in reference to silicene. The in-plane stiffness and Poisson ratio are reduced by a factor of 16% and 26%, respectively. However, hydrogenation/dehydrogenation has little effect on its ultimate tensile strengths. We obtained high order elastic constants for a rigorous continuum description of the nonlinear elastic response. The limitation of second, third, fourth, and fifth order elastic constants are in the strain range of 0.02, 0.08, and 0.13, and 0.21, respectively. The pressure effect on the second order elastic constants and Poisson's ratio were predicted from the third order elastic constants. Our results could provide a safe guide for promising applications and strain-engineering the functions and properties of silicane monolayers.

  5. Limits to growth reconsidered.

    Science.gov (United States)

    Hagen, E E

    1972-01-01

    In their book, ''The Limits of Growth,'' the authors conclude that through pollution, exhaustion of natural resources, and limits to the food supply, the world faces a catastrophic fall in population and in living standards by the middle of the 21st century. The authors fail to state, however, 1 centrally important assumption underlying their results, but which is present through their omission of the contrary assumption. In their model the continuing technical progress that has been a primary feature of the material world for the past 200 years suddenly ceases. The assumptions of the model presented in ''Limits of Growth'' are not the assumptions other analysts make - these are strangely unrealistic. These assumptions require closer examination. The assumption concerning population assumes that the sole determinants of birthrates are the level of industrialization and the food supply. This is not good demography, for demographers have long recognized that it may have been the decrease in death rates, not industrialization or the rise in income, that caused the decrease in birthrates. Furthermore, their theory that many of the natural resources are irreplacable is like the belief that the sun revolves around the earth. It is obvious and false. It neglects that part of technical process which includes invention of new natural resources. Technical advance is needed and the following are some of the problems that technical advance must overcome: 1) a need to discover how to increase food production progressively while preventing the runoff of chemical fertilizers from the soil into waterways, 2) the ''natural'' minerals on which until recently all have depended are ''biodegradable,'' 3) there is a similar problem with radioactive nuclear wastes; 4) energy must dissipate into heat; and 5) there is a need to hasten the decline in birthrates throughout the world. In conclusion, indefinitely continuing growth is not regarded as desirable only as possible.

  6. Limits of Lubrication in

    DEFF Research Database (Denmark)

    Olsson, David Dam

    of different lubricants indicate that both commercial and prototype, environmental friendly lubricants do not perform as well as hazardous lubricants such as chlorinated paraffin oils. Dry-in lubricants and polymer-coated sheets have been found to perform very poorly in punching and blanking due to shearing......-models corresponds well to experimental results in terms of lubricant film breakdown and subsequently pick-up development. Punching and blanking have been investigated regarding tribological conditions in case of using stainless steel workpiece materials. However, this has called for development of a new test method...

  7. Orind Refractories Limited

    Institute of Scientific and Technical Information of China (English)

    Mr R. Mishra; Group Manging Director

    2005-01-01

    @@ "Sight can be acquired, Vision cannot". Orind Refractories Limited (ORIND), China was formed with this rare vision. At a time when the world was testing the tepid waters of China; Mr. Ravin Jhunjhunwala, Chairman of ORIND and the management of ORIND India had looked over the Great Wall to begin a journey of success. Incorported on 18th August 1994 with an initial investment of USD 5 million, ORL caters to the ever-demanding needs of the steel industry and beyond. Incidentally ORIND was the first wholly owned India company to set up base in China. Pesently, ORIND China has a 616 strong work force including 23 expatriates.

  8. Drinking to the Limit

    DEFF Research Database (Denmark)

    Järvinen, Margaretha; Ellersgaard, Christoph Houman; Larsen, Anton Grau

    2014-01-01

    The aim of this article is to analyse social status differences in alcohol norms and practices seen from the perspective of ‘health governance’. Survey data on 1442 employees in a middle-sized, Danish firm are used to construct a Bourdieu-inspired social space, tied to four forms of capital: econ...... by the Danish National Health Board. Rather, this article identifies a relatively large group of high-positioned respondents balancing at the limits of risky drinking – or transgressing them, if measured by international standards....

  9. Limitations in forensic odontology

    Directory of Open Access Journals (Sweden)

    B Kavitha

    2009-01-01

    Full Text Available The concept of using dental evidence in forensic investigation has kindled so much interest in the recent past that forensic odontology is even suggested as the single positive identification method to solve certain forensic cases. In this process, the shortcomings in forensic odontology though few are overlooked. These discrepancies associated with various methods are to be weighed cautiously to make forensic odontology a more accurate, reliable, and reproducible investigatory science. In this paper, we present our understanding of the limitations in various methods employed in forensic odontology.

  10. Marketing with limited budget

    OpenAIRE

    Smirnova, Daria

    2017-01-01

    The purpose of this research-based thesis was to get an idea how managers of two small resembling hotels of a specific region deal with marketing process with a limited budget. In addition, the aim of the thesis was to examine if hotel managers who were interviewed perceive marketing only in the way of ‘promotion’ rather than marketing research, marketing mix and marketing environment theories. It was also found out if hotel managers of those hotels consider marketing as a key to successful h...

  11. Quasineutral limit of a standard drift diffusion model for semiconductors

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The limit of vanishing Debye length (charge neutral limit ) in a nonlinear bipolar drift-diffusion model for semiconductors without pn-junction (i.e. without a bipolar background charge ) is studied. The quasineutral limit (zero-Debye-length limit) is performed rigorously by using the weak compactness argument and the so-called entropy functional which yields appropriate uniform estimates.

  12. Limits to biofuels

    Directory of Open Access Journals (Sweden)

    Johansson S.

    2013-06-01

    Full Text Available Biofuel production is dependent upon agriculture and forestry systems, and the expectations of future biofuel potential are high. A study of the global food production and biofuel production from edible crops implies that biofuel produced from edible parts of crops lead to a global deficit of food. This is rather well known, which is why there is a strong urge to develop biofuel systems that make use of residues or products from forest to eliminate competition with food production. However, biofuel from agro-residues still depend upon the crop production system, and there are many parameters to deal with in order to investigate the sustainability of biofuel production. There is a theoretical limit to how much biofuel can be achieved globally from agro-residues and this amounts to approximately one third of todays’ use of fossil fuels in the transport sector. In reality this theoretical potential may be eliminated by the energy use in the biomass-conversion technologies and production systems, depending on what type of assessment method is used. By surveying existing studies on biofuel conversion the theoretical limit of biofuels from 2010 years’ agricultural production was found to be either non-existent due to energy consumption in the conversion process, or up to 2–6000TWh (biogas from residues and waste and ethanol from woody biomass in the more optimistic cases.

  13. Smoothness of limit functors

    Indian Academy of Sciences (India)

    Benedictus Margaux

    2015-05-01

    Let be a scheme. Assume that we are given an action of the one dimensional split torus $\\mathbb{G}_{m,S}$ on a smooth affine -scheme $\\mathfrak{X}$. We consider the limit (also called attractor) subfunctor $\\mathfrak{X}_{}$ consisting of points whose orbit under the given action `admits a limit at 0’. We show that $\\mathfrak{X}_{}$ is representable by a smooth closed subscheme of $\\mathfrak{X}$. This result generalizes a theorem of Conrad et al. (Pseudo-reductive groups (2010) Cambridge Univ. Press) where the case when $\\mathfrak{X}$ is an affine smooth group and $\\mathbb{G}_{m,S}$ acts as a group automorphisms of $\\mathfrak{X}$ is considered. It also occurs as a special case of a recent result by Drinfeld on the action of $\\mathbb{G}_{m,S}$ on algebraic spaces (Proposition 1.4.20 of Drinfeld V, On algebraic spaces with an action of $\\mathfrak{G}_{m}$, preprint 2013) in case is of finite type over a field.

  14. Limitations of inclusive fitness.

    Science.gov (United States)

    Allen, Benjamin; Nowak, Martin A; Wilson, Edward O

    2013-12-10

    Until recently, inclusive fitness has been widely accepted as a general method to explain the evolution of social behavior. Affirming and expanding earlier criticism, we demonstrate that inclusive fitness is instead a limited concept, which exists only for a small subset of evolutionary processes. Inclusive fitness assumes that personal fitness is the sum of additive components caused by individual actions. This assumption does not hold for the majority of evolutionary processes or scenarios. To sidestep this limitation, inclusive fitness theorists have proposed a method using linear regression. On the basis of this method, it is claimed that inclusive fitness theory (i) predicts the direction of allele frequency changes, (ii) reveals the reasons for these changes, (iii) is as general as natural selection, and (iv) provides a universal design principle for evolution. In this paper we evaluate these claims, and show that all of them are unfounded. If the objective is to analyze whether mutations that modify social behavior are favored or opposed by natural selection, then no aspect of inclusive fitness theory is needed.

  15. (Limiting the greenhouse effect)

    Energy Technology Data Exchange (ETDEWEB)

    Rayner, S.

    1991-01-07

    Traveler attended the Dahlem Research Conference organized by the Freien Universitat, Berlin. The subject of the conference was Limiting the Greenhouse Effect: Options for Controlling Atmospheric CO{sub 2} Accumulation. Like all Dahlem workshops, this was a meeting of scientific experts, although the disciplines represented were broader than usual, ranging across anthropology, economics, international relations, forestry, engineering, and atmospheric chemistry. Participation by scientists from developing countries was limited. The conference was divided into four multidisciplinary working groups. Traveler acted as moderator for Group 3 which examined the question What knowledge is required to tackle the principal social and institutional barriers to reducing CO{sub 2} emissions'' The working rapporteur was Jesse Ausubel of Rockefeller University. Other working groups examined the economic costs, benefits, and technical feasibility of options to reduce emissions per unit of energy service; the options for reducing energy use per unit of GNP; and the significant of linkage between strategies to reduce CO{sub 2} emissions and other goals. Draft reports of the working groups are appended. Overall, the conference identified a number of important research needs in all four areas. It may prove particularly important in bringing the social and institutional research needs relevant to climate change closer to the forefront of the scientific and policy communities than hitherto.

  16. Personal Freedom beyond Limits

    Directory of Open Access Journals (Sweden)

    Juan Fernando Sellés

    2013-07-01

    Full Text Available In this work we distinguish between freedom in the human manifestations (intelligence, will,actions and personal freedom in the personal intimacy. This second is beyond the freedom reached bythe classic and modern thought, since it takes root in the personnel act of being. Because of it, it is not possible to characterize this freedom like the classic description as ‘domain over the own acts’, becauseit is a description of ‘categorial’ order; neither like present day ‘autonomy’ or ‘independence’, becausethe existence of one person alone is impossible, since ‘person’ means relation, personal free openingto other persons, description of the ‘transcendental’ order and, therefore, to the margin of limits.

  17. Universal Limit on Communication

    CERN Document Server

    Bousso, Raphael

    2016-01-01

    I derive a universal upper bound on the capacity of any communication channel between two distant systems. The Holevo quantity, and hence the mutual information, is at most of order $E \\Delta t / \\hbar$, where $E$ the average energy of the signal, and $\\Delta t$ is the amount of time for which detectors operate. The bound does not depend on the size or mass of the emitting and receiving systems, nor on the nature of the signal. No restrictions on preparing and processing the signal are imposed. As an example, I consider the encoding of information in the transverse or angular position of a signal emitted and received by systems of arbitrarily large cross-section. In the limit of a large message space, quantum effects become important even if individual signals are classical, and the bound is upheld.

  18. Clinical limitations of Invisalign.

    Science.gov (United States)

    Phan, Xiem; Ling, Paul H

    2007-04-01

    Adult patients seeking orthodontic treatment are increasingly motivated by esthetic considerations. The majority of these patients reject wearing labial fixed appliances and are looking instead to more esthetic treatment options, including lingual orthodontics and Invisalign appliances. Since Align Technology introduced the Invisalign appliance in 1999 in an extensive public campaign, the appliance has gained tremendous attention from adult patients and dental professionals. The transparency of the Invisalign appliance enhances its esthetic appeal for those adult patients who are averse to wearing conventional labial fixed orthodontic appliances. Although guidelines about the types of malocclusions that this technique can treat exist, few clinical studies have assessed the effectiveness of the appliance. A few recent studies have outlined some of the limitations associated with this technique that clinicians should recognize early before choosing treatment options.

  19. The Limits to Relevance

    Science.gov (United States)

    Averill, M.; Briggle, A.

    2006-12-01

    Science policy and knowledge production lately have taken a pragmatic turn. Funding agencies increasingly are requiring scientists to explain the relevance of their work to society. This stems in part from mounting critiques of the "linear model" of knowledge production in which scientists operating according to their own interests or disciplinary standards are presumed to automatically produce knowledge that is of relevance outside of their narrow communities. Many contend that funded scientific research should be linked more directly to societal goals, which implies a shift in the kind of research that will be funded. While both authors support the concept of useful science, we question the exact meaning of "relevance" and the wisdom of allowing it to control research agendas. We hope to contribute to the conversation by thinking more critically about the meaning and limits of the term "relevance" and the trade-offs implicit in a narrow utilitarian approach. The paper will consider which interests tend to be privileged by an emphasis on relevance and address issues such as whose goals ought to be pursued and why, and who gets to decide. We will consider how relevance, narrowly construed, may actually limit the ultimate utility of scientific research. The paper also will reflect on the worthiness of research goals themselves and their relationship to a broader view of what it means to be human and to live in society. Just as there is more to being human than the pragmatic demands of daily life, there is more at issue with knowledge production than finding the most efficient ways to satisfy consumer preferences or fix near-term policy problems. We will conclude by calling for a balanced approach to funding research that addresses society's most pressing needs but also supports innovative research with less immediately apparent application.

  20. Performing Performance Design Anglonationally

    DEFF Research Database (Denmark)

    2016-01-01

    Video recording of pecha kucha style bricolage aural enactment of an international version of performance design......Video recording of pecha kucha style bricolage aural enactment of an international version of performance design...

  1. Performing Performance Design Anglonationally

    DEFF Research Database (Denmark)

    2016-01-01

    Video recording of pecha kucha style bricolage aural enactment of an international version of performance design......Video recording of pecha kucha style bricolage aural enactment of an international version of performance design...

  2. Pure Phase Solubility Limits: LANL

    Energy Technology Data Exchange (ETDEWEB)

    C. Stockman

    2001-01-26

    The natural and engineered system at Yucca Mountain (YM) defines the site-specific conditions under which one must determine to what extent the engineered and the natural geochemical barriers will prevent the release of radioactive material from the repository. Most important mechanisms for retention or enhancement of radionuclide transport include precipitation or co-precipitation of radionuclide-bearing solid phases (solubility limits), complexation in solution, sorption onto surfaces, colloid formation, and diffusion. There may be many scenarios that could affect the near-field environment, creating chemical conditions more aggressive than the conditions presented by the unperturbed system (such as pH changes beyond the range of 6 to 9 or significant changes in the ionic strength of infiltrated waters). For an extended period of time, the near-field water composition may be quite different and more extreme in pH, ionic strength, and CO{sub 2} partial pressure (or carbonate concentration) than waters at some distance from the repository. Reducing conditions, high pH (up to 11), and low carbonate concentration may be present in the near-field after reaction of infiltrating groundwater with engineered barrier systems, such as cementitious materials. In the far-field, conditions are controlled by the rock-mass buffer providing a near-neutral, oxidizing, low-ionic-strength environment that controls radionuclide solubility limits and sorption capacities. There is the need for characterization of variable chemical conditions that affect solubility, speciation, and sorption reactions. Modeling of the groundwater chemistry is required and leads to an understanding of solubility and speciation of the important radionuclides. Because experimental studies cannot be performed under the numerous potential chemical conditions, solubility limitations must rely on geochemical modeling of the radionuclide's chemistry. Fundamental thermodynamic properties, such as solubility

  3. Performance benefits and limitations of a camera network

    Science.gov (United States)

    Carr, Peter; Thomas, Paul J.; Hornsey, Richard

    2005-06-01

    Visual information is of vital significance to both animals and artificial systems. The majority of mammals rely on two images, each with a resolution of 107-108 'pixels' per image. At the other extreme are insect eyes where the field of view is segmented into 103-105 images, each comprising effectively one pixel/image. The great majority of artificial imaging systems lie nearer to the mammalian characteristics in this parameter space, although electronic compound eyes have been developed in this laboratory and elsewhere. If the definition of a vision system is expanded to include networks or swarms of sensor elements, then schools of fish, flocks of birds and ant or termite colonies occupy a region where the number of images and the pixels/image may be comparable. A useful system might then have 105 imagers, each with about 104-105 pixels. Artificial analogs to these situations include sensor webs, smart dust and co-ordinated robot clusters. As an extreme example, we might consider the collective vision system represented by the imminent existence of ~109 cellular telephones, each with a one-megapixel camera. Unoccupied regions in this resolution-segmentation parameter space suggest opportunities for innovative artificial sensor network systems. Essential for the full exploitation of these opportunities is the availability of custom CMOS image sensor chips whose characteristics can be tailored to the application. Key attributes of such a chip set might include integrated image processing and control, low cost, and low power. This paper compares selected experimentally determined system specifications for an inward-looking array of 12 cameras with the aid of a camera-network model developed to explore the tradeoff between camera resolution and the number of cameras.

  4. Ion Trap Quantum Computers: Performance Limits and Experimental Progress

    Science.gov (United States)

    Hughes, Richard

    1998-03-01

    In a quantum computer information would be represented by the quantum mechanical states of suitable atomic-scale systems. (A single bit of information represented by a two-level quantum system is known as a qubit.) This notion leads to the possibility of computing with quantum mechanical superpositions of numbers ("quantum parallelism"), which for certain problems would make Quantum/quantum.html>quantum computation very much more efficient than classical computation. The possibility of rapidly factoring the large integers used in public-key cryptography is an important example. (Public key cryptosystems derive their security from the difficuty of factoring, and similar problems, with conventional computers.) Quantum computational hardware development is in its infancy, but an experimental study of quantum computation with laser-cooled trapped calcium ions that is under way at Los Alamos will be described. One of the pricipal obstacles to practical quantum computation is the inevitable loss of quantum coherence of the complex quantum states involved. The results of a theoretical analysis showing that quantum factoring of small integers should be possible with trapped ions will be presented. The prospects for larger-scale computations will be discussed.

  5. Fundamental electronic mechanisms limiting the performance of solar cells

    Science.gov (United States)

    Lindholm, F. A.; Sah, C.-T.

    1977-01-01

    Attention is focused on distortion in the energy band, and carrier recombination and generation rates (lifetimes), as the two dominant mechanisms. Spatial dependences associated with these two mechanisms, in the direction normal to the surface illuminated by the sun and in the direction tangential to that surface, are also emphasized as crucial factors in governing the efficiency of solar cells. Electronic parameters for the set of differential equations characterizing transport, recombination, and generation of carriers, and interband and band-bound transition rates, are studied.

  6. What limits the performance of current invasive Brain Machine Interfaces?

    Directory of Open Access Journals (Sweden)

    Gytis eBaranauskas

    2014-04-01

    Full Text Available The concept of a brain-machine interface (BMI or a computer-brain interface is simple: BMI creates a communication pathway for a direct control by brain of an external device. In reality BMIs are very complex devices and only recently the increase in computing power of microprocessors enabled a boom in BMI research that continues almost unabated to this date, the high point being the insertion of electrode arrays into the brains of 5 human patients in a clinical trial run by Cyberkinetics with few other clinical tests still in progress. Meanwhile several EEG-based BMI devices (non-invasive BMIs were launched commercially. Modern electronics and dry electrode technology made possible to drive the cost of some of these devices below few hundred dollars. However, the initial excitement of the direct control by brain waves of a computer or other equipment is dampened by large efforts required for learning, high error rates and slow response speed. All these problems are directly related to low information transfer rates typical for such EEG-based BMIs. In invasive BMIs employing multiple electrodes inserted into the brain one may expect much higher information transfer rates than in EEG-based BMIs because, in theory, each electrode provides an independent information channel. However, although invasive BMIs require more expensive equipment and have ethical problems related to the need to insert electrodes in the live brain, such financial and ethical costs are often not offset by a dramatic improvement in the information transfer rate. Thus the main topic of this review is why in invasive BMIs an apparently much larger information content obtained with multiple extracellular electrodes does not translate into much higher rates of information transfer? This paper explores possible answers to this question by concluding that more research on what movement parameters are encoded by neurons in motor cortex is needed before we can enjoy the next generation BMIs.

  7. Performance Limits of Pulse Tube Cryocoolers Using 3HE

    Science.gov (United States)

    Kittel, P.

    2008-03-01

    The enthalpy, entropy, and exergy flows resulting from the real gas effects of 3He in ideal pulse tube cryocoolers are described. The discussion follows a previous description of the real gas effects of 4He in ideal pulse tube cryocoolers and makes use of a recently developed model of the thermophysical properties of 3He. This model is used to describe how the thermodynamic flows are affected by real gas phenomena of 3He and compares these effects to similar effects for 4He. The analysis was done over the pressure range 0.3-2 MPa and temperatures down to 1 K. At 2 MPa there is almost no difference in the cooling power between 3He and 4He. At lower pressures, using 3He is advantageous. There is a 1-2 K reduction in the 3He cooling power vs. temperature curves compared to those for 4He in the 0.3-1 MPa range.

  8. What limits the performance of current invasive brain machine interfaces?

    Science.gov (United States)

    Baranauskas, Gytis

    2014-01-01

    The concept of a brain-machine interface (BMI) or a computer-brain interface is simple: BMI creates a communication pathway for a direct control by brain of an external device. In reality BMIs are very complex devices and only recently the increase in computing power of microprocessors enabled a boom in BMI research that continues almost unabated to this date, the high point being the insertion of electrode arrays into the brains of 5 human patients in a clinical trial run by Cyberkinetics with few other clinical tests still in progress. Meanwhile several EEG-based BMI devices (non-invasive BMIs) were launched commercially. Modern electronics and dry electrode technology made possible to drive the cost of some of these devices below few hundred dollars. However, the initial excitement of the direct control by brain waves of a computer or other equipment is dampened by large efforts required for learning, high error rates and slow response speed. All these problems are directly related to low information transfer rates typical for such EEG-based BMIs. In invasive BMIs employing multiple electrodes inserted into the brain one may expect much higher information transfer rates than in EEG-based BMIs because, in theory, each electrode provides an independent information channel. However, although invasive BMIs require more expensive equipment and have ethical problems related to the need to insert electrodes in the live brain, such financial and ethical costs are often not offset by a dramatic improvement in the information transfer rate. Thus the main topic of this review is why in invasive BMIs an apparently much larger information content obtained with multiple extracellular electrodes does not translate into much higher rates of information transfer? This paper explores possible answers to this question by concluding that more research on what movement parameters are encoded by neurons in motor cortex is needed before we can enjoy the next generation BMIs.

  9. Limits to Nonlinear Inversion

    DEFF Research Database (Denmark)

    Mosegaard, Klaus

    2012-01-01

    For non-linear inverse problems, the mathematical structure of the mapping from model parameters to data is usually unknown or partly unknown. Absence of information about the mathematical structure of this function prevents us from presenting an analytical solution, so our solution depends on our......-heuristics are inefficient for large-scale, non-linear inverse problems, and that the 'no-free-lunch' theorem holds. We discuss typical objections to the relevance of this theorem. A consequence of the no-free-lunch theorem is that algorithms adapted to the mathematical structure of the problem perform more efficiently than...

  10. Kyphoplasty: Chances and limits

    Directory of Open Access Journals (Sweden)

    Mueller Christian

    2005-01-01

    Full Text Available Kyphoplasty provides a minimal-invasive surgical technique for the cement augmentation of vertebral bodies following osteoprotic compression fractures or malignant processes. Kyphoplasty has been developed as an advancement of vertebroplasty. Both procedures feature high-success rates in terms of reliable and lasting reduction of pain. Advantages of kyphoplasty over vertebroplasty are to be seen in the possibility of deformity correction as well as in a decreased risk of cement leakage, which represents the most important source for clinical complications. Long-term experiences with the effect of cementing vertebral bodies are sparse. Thus indications and possibilities have to be judged realistically. Conditions, which have to be considered before performing kyphoplasty or vertebroplasty include age of the patient, age of the fracture, degree of deformation and additional degenerative changes of the spine. This article summarizes the present research and literature as well as indications and contraindications and is thought to provide guidelines for the aforementioned decision-making processes.

  11. The limits of subfunctionalization

    Directory of Open Access Journals (Sweden)

    Bergman Aviv

    2007-11-01

    Full Text Available Abstract Background The duplication-degeneration-complementation (DDC model has been proposed as an explanation for the unexpectedly high retention of duplicate genes. The hypothesis proposes that, following gene duplication, the two gene copies degenerate to perform complementary functions that jointly match that of the single ancestral gene, a process also known as subfunctionalization. We distinguish between subfunctionalization at the regulatory level and at the product level (e.g within temporal or spatial expression domains. Results In contrast to what is expected under the DDC model, we use in silico modeling to show that regulatory subfunctionalization is expected to peak and then decrease significantly. At the same time, neofunctionalization (recruitment of novel interactions increases monotonically, eventually affecting the regulatory elements of the majority of genes. Furthermore, since this process occurs under conditions of stabilizing selection, there is no need to invoke positive selection. At the product level, the frequency of subfunctionalization is no higher than would be expected by chance, a finding that was corroborated using yeast microarray time-course data. We also find that product subfunctionalization is not necessarily caused by regulatory subfunctionalization. Conclusion Our results suggest a more complex picture of post-duplication evolution in which subfunctionalization plays only a partial role in conjunction with redundancy and neofunctionalization. We argue that this behavior is a consequence of the high evolutionary plasticity in gene networks.

  12. Limits of Executive Control

    Science.gov (United States)

    Verbruggen, Frederick; McAndrew, Amy; Weidemann, Gabrielle; Stevens, Tobias; McLaren, Ian P. L.

    2016-01-01

    Cognitive-control theories attribute action control to executive processes that modulate behavior on the basis of expectancy or task rules. In the current study, we examined corticospinal excitability and behavioral performance in a go/no-go task. Go and no-go trials were presented in runs of five, and go and no-go runs alternated predictably. At the beginning of each trial, subjects indicated whether they expected a go trial or a no-go trial. Analyses revealed that subjects immediately adjusted their expectancy ratings when a new run started. However, motor excitability was primarily associated with the properties of the previous trial, rather than the predicted properties of the current trial. We also observed a large latency cost at the beginning of a go run (i.e., reaction times were longer for the first trial in a go run than for the second trial). These findings indicate that actions in predictable environments are substantially influenced by previous events, even if this influence conflicts with conscious expectancies about upcoming events. PMID:27000177

  13. Food Cravings Consume Limited Cognitive Resources

    Science.gov (United States)

    Kemps, Eva; Tiggemann, Marika; Grigg, Megan

    2008-01-01

    Using Tiffany's (1990) cognitive model of drug use and craving as a theoretical basis, the present experiments investigated whether cravings for food expend limited cognitive resources. Cognitive performance was assessed by simple reaction time (Experiment 1) and an established measure of working memory capacity, the operation span task…

  14. Mass limit for the lightest neutralino

    CERN Document Server

    Buskulic, Damir; Décamp, D; Ghez, P; Goy, C; Lees, J P; Lucotte, A; Minard, M N; Nief, J Y; Odier, P; Pietrzyk, B; Casado, M P; Chmeissani, M; Crespo, J M; Delfino, M C; Efthymiopoulos, I; Fernández, E; Fernández-Bosman, M; Garrido, L; Juste, A; Martínez, M; Orteu, S; Padilla, C; Park, I C; Pascual, A; Perlas, J A; Riu, I; Sánchez, F; Teubert, F; Colaleo, A; Creanza, D; De Palma, M; Gelao, G; Girone, M; Iaselli, Giuseppe; Maggi, G; Maggi, M; Marinelli, N; Nuzzo, S; Ranieri, A; Raso, G; Ruggieri, F; Selvaggi, G; Silvestris, L; Tempesta, P; Zito, G; Huang, X; Lin, J; Ouyang, Q; Wang, T; Xie, Y; Xu, R; Xue, S; Zhang, J; Zhang, L; Zhao, W; Alemany, R; Bazarko, A O; Bright-Thomas, P G; Cattaneo, M; Comas, P; Coyle, P; Drevermann, H; Forty, Roger W; Frank, M; Hagelberg, R; Harvey, J; Janot, P; Jost, B; Kneringer, E; Knobloch, J; Lehraus, Ivan; Lutters, G; Martin, E B; Mato, P; Minten, Adolf G; Miquel, R; Mir, L M; Moneta, L; Oest, T; Pacheco, A; Pusztaszeri, J F; Ranjard, F; Rensing, P E; Rolandi, Luigi; Schlatter, W D; Schmelling, M; Schmitt, M; Schneider, O; Tejessy, W; Tomalin, I R; Venturi, A; Wachsmuth, H W; Wagner, A; Ajaltouni, Ziad J; Barrès, A; Boyer, C; Falvard, A; Gay, P; Guicheney, C; Henrard, P; Jousset, J; Michel, B; Monteil, S; Montret, J C; Pallin, D; Perret, P; Podlyski, F; Proriol, J; Rosnet, P; Rossignol, J M; Fearnley, Tom; Hansen, J B; Hansen, J D; Hansen, J R; Hansen, P H; Nilsson, B S; Rensch, B; Wäänänen, A; Kyriakis, A; Markou, C; Simopoulou, Errietta; Vayaki, Anna; Zachariadou, K; Blondel, A; Brient, J C; Rougé, A; Rumpf, M; Valassi, Andrea; Videau, H L; Focardi, E; Parrini, G; Corden, M; Georgiopoulos, C H; Jaffe, D E; Antonelli, A; Bencivenni, G; Bologna, G; Bossi, F; Campana, P; Capon, G; Casper, David William; Chiarella, V; Felici, G; Laurelli, P; Mannocchi, G; Murtas, F; Murtas, G P; Passalacqua, L; Pepé-Altarelli, M; Curtis, L; Dorris, S J; Halley, A W; Knowles, I G; Lynch, J G; O'Shea, V; Raine, C; Reeves, P; Scarr, J M; Smith, K; Teixeira-Dias, P; Thompson, A S; Thomson, F; Thorn, S; Turnbull, R M; Becker, U; Geweniger, C; Graefe, G; Hanke, P; Hansper, G; Hepp, V; Kluge, E E; Putzer, A; Schmidt, M; Sommer, J; Tittel, K; Werner, S; Wunsch, M; Abbaneo, D; Beuselinck, R; Binnie, David M; Cameron, W; Dornan, Peter J; Morawitz, P; Moutoussi, A; Nash, J; Sedgbeer, J K; Stacey, A M; Williams, M D; Dissertori, G; Girtler, P; Kuhn, D; Rudolph, G; Betteridge, A P; Bowdery, C K; Colrain, P; Crawford, G; Finch, A J; Foster, F; Hughes, G; Sloan, Terence; Whelan, E P; Williams, M I; Galla, A; Greene, A M; Hoffmann, C; Jacobs, K; Kleinknecht, K; Quast, G; Renk, B; Rohne, E; Sander, H G; Van Gemmeren, P; Zeitnitz, C; Aubert, Jean-Jacques; Bencheikh, A M; Benchouk, C; Bonissent, A; Bujosa, G; Calvet, D; Carr, J; Diaconu, C A; Konstantinidis, N P; Payre, P; Rousseau, D; Talby, M; Sadouki, A; Thulasidas, M; Tilquin, A; Trabelsi, K; Aleppo, M; Ragusa, F; Bauer, C; Berlich, R; Blum, Walter; Büscher, V; Dietl, H; Dydak, Friedrich; Ganis, G; Gotzhein, C; Kroha, H; Lütjens, G; Lutz, Gerhard; Männer, W; Moser, H G; Richter, R H; Rosado-Schlosser, A; Schael, S; Settles, Ronald; Seywerd, H C J; Saint-Denis, R; Stenzel, H; Wiedenmann, W; Wolf, G; Boucrot, J; Callot, O; Cordier, A; Davier, M; Duflot, L; Grivaz, J F; Höcker, A; Jacholkowska, A; Jacquet, M; Kim, D W; Le Diberder, F R; Lefrançois, J; Lutz, A M; Nikolic, I A; Park, H J; Schune, M H; Simion, S; Veillet, J J; Videau, I; Zerwas, D; Azzurri, P; Bagliesi, G; Batignani, G; Bettarini, S; Bozzi, C; Calderini, G; Carpinelli, M; Ciocci, M A; Ciulli, V; Dell'Orso, R; Fantechi, R; Ferrante, I; Giassi, A; Gregorio, A; Ligabue, F; Lusiani, A; Marrocchesi, P S; Messineo, A; Palla, Fabrizio; Rizzo, G; Sanguinetti, G; Sciabà, A; Spagnolo, P; Steinberger, Jack; Tenchini, Roberto; Tonelli, G; Vannini, C; Verdini, P G; Walsh, J; Blair, G A; Bryant, L M; Cerutti, F; Chambers, J T; Gao, Y; Green, M G; Medcalf, T; Perrodo, P; Strong, J A; Von Wimmersperg-Töller, J H; Botterill, David R; Clifft, R W; Edgecock, T R; Haywood, S; Maley, P; Norton, P R; Thompson, J C; Wright, A E; Bloch-Devaux, B; Colas, P; Emery, S; Kozanecki, Witold; Lançon, E; Lemaire, M C; Locci, E; Marx, B; Pérez, P; Rander, J; Renardy, J F; Roussarie, A; Schuller, J P; Schwindling, J; Trabelsi, A; Vallage, B; Black, S N; Dann, J H; Johnson, R P; Kim, H Y; Litke, A M; McNeil, M A; Taylor, G; Booth, C N; Boswell, R; Brew, C A J; Cartwright, S L; Combley, F; Köksal, A; Lehto, M H; Newton, W M; Reeve, J; Thompson, L F; Böhrer, A; Brandt, S; Cowan, G D; Grupen, Claus; Saraiva, P; Smolik, L; Stephan, F; Apollonio, M; Bosisio, L; Della Marina, R; Giannini, G; Gobbo, B; Musolino, G; Pütz, J; Rothberg, J E; Wasserbaech, S R; Williams, R W; Armstrong, S R; Elmer, P; Feng, Z; Ferguson, D P S; Gao, Y S; González, S; Grahl, J; Greening, T C; Hayes, O J; Hu, H; McNamara, P A; Nachtman, J M; Orejudos, W; Pan, Y B; Saadi, Y; Scott, I J; Walsh, A M; Wu Sau Lan; Wu, X; Yamartino, J M; Zheng, M; Zobernig, G

    1996-01-01

    Indirect limits on the mass of the lightest neutralino are derived from the results of searches for charginos, neutralinos, and sleptons performed with data taken by the ALEPH Collaboration at centre-of-mass energies near the Z peak and at 130 and 136 GeV. Within the context of the Minimal Supersymmetric Standard Model and when $M_{\\tilde\

  15. Sensitivity Limitations for Multivariable Linear Filtering

    Directory of Open Access Journals (Sweden)

    Steven R. Weller

    2007-01-01

    Full Text Available This paper examines fundamental limitations in performance which apply to linear filtering problems associated with multivariable systems having as many inputs as outputs. The results of this paper quantify unavoidable limitations in the sensitivity of state estimates to process and measurement disturbances, as represented by the maximum singular values of the relevant transfer matrices. These limitations result from interpolation constraints imposed by open right half-plane poles and zeros in the transfer matrices linking process noise and output noise with state estimates. Using the Poisson integral inequality, this paper shows how sensitivity limitations and tradeoffs in multivariable filtering problems are intimately related to the directionality properties of the open right half-plane poles and zeros in these transfer matrices.

  16. The limits on trypanosomatid morphological diversity.

    Directory of Open Access Journals (Sweden)

    Richard John Wheeler

    Full Text Available Cell shape is one, often overlooked, way in which protozoan parasites have adapted to a variety of host and vector environments and directional transmissions between these environments. Consequently, different parasite life cycle stages have characteristic morphologies. Trypanosomatid parasites are an excellent example of this in which large morphological variations between species and life cycle stage occur, despite sharing well-conserved cytoskeletal and membranous structures. Here, using previously published reports in the literature of the morphology of 248 isolates of trypanosomatid species from different hosts, we perform a meta-analysis of the occurrence and limits on morphological diversity of different classes of trypanosomatid morphology (trypomastigote, promastigote, etc. in the vertebrate bloodstream and invertebrate gut environments. We identified several limits on cell body length, cell body width and flagellum length diversity which can be interpreted as biomechanical limits on the capacity of the cell to attain particular dimensions. These limits differed for morphologies with and without a laterally attached flagellum which we suggest represent two morphological superclasses, the 'juxtaform' and 'liberform' superclasses. Further limits were identified consistent with a selective pressure from the mechanical properties of the vertebrate bloodstream environment; trypanosomatid size showed limits relative to host erythrocyte dimensions. This is the first comprehensive analysis of the limits of morphological diversity in any protozoan parasite, revealing the morphogenetic constraints and extrinsic selection pressures associated with the full diversity of trypanosomatid morphology.

  17. CFO of CNOOC Limited Changed

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ CNOOC Limited announced on December 24 that Yang Hua, Senior Vice President of CNOOC Limited and President of CNOOC International Limied will succeed Dr.Mark Qiu as Chief Financial Officer effective on January 1,2005.

  18. Charter Halibut Limited Access Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This limited access system limits the number of charter vessels that may participate in the guided sport fishery for halibut in area 2C and 3A. NMFS issues a charter...

  19. The Value of Time Limits on Internet Quizzes

    Science.gov (United States)

    Brothen, Thomas; Wambach, Cathrine

    2004-01-01

    This study evaluated 15-min time limits on 10-item multiple-choice quizzes delivered over the Internet. Students in a computer-assisted course in human development spent less time on quizzes and performed better on exams when they had time limits on their quizzes. We conclude that time limits are associated with better learning and exam…

  20. Performance prediction and flow-field analysis of rotors in hover using a coupled Euler/boundary layer method; Previsions des performances et de l`ecoulement pour des rotors en vol stationnaire par une methode couplee Euler/couche limite

    Energy Technology Data Exchange (ETDEWEB)

    Beaumier, P. [ONERA, 92 - Chatillon (France); Castellin, C.; Arnaud, G. [Eurocopter France, 13 - Marignane (France)

    1998-12-31

    The performance prediction of helicopter in hover is of key importance for manufacturers because hover is a design configuration for the definition of a rotor-craft. A lot of efforts have been made for more than 10 years all over the world in order to develop and validate numerical methods based on CFD. An Euler method (WAVES) developed by ONERA and coupled with a boundary layer code (MI3DI) is presented, validated and applied to compute the total performance of rotors with different tip shapes. A new boundary condition for the Euler code has been tested and enables better calculation by eliminating `numerical` recirculation. The code has demonstrated its ability to rank two rotors with different planforms in good agreement with experiment. Under industrial requirements new grid strategies have been studied and should allow to reduce CPU time consumption. It is shown that WAVES/MI3DI can be efficiently used in the aerodynamic design process of a new rotor. (authors) 7 refs.

  1. Guidelines for setting speed limits

    CSIR Research Space (South Africa)

    Wium, DJW

    1986-02-01

    Full Text Available A method is described for setting the speed limit for a particular road section. Several speed limits based on different criteria are described for each of nine traffic and road factors. The most appropriate speed limit for each relevant factor...

  2. Pure Phase Solubility Limits: LANL

    Energy Technology Data Exchange (ETDEWEB)

    C. Stockman

    2001-01-26

    The natural and engineered system at Yucca Mountain (YM) defines the site-specific conditions under which one must determine to what extent the engineered and the natural geochemical barriers will prevent the release of radioactive material from the repository. Most important mechanisms for retention or enhancement of radionuclide transport include precipitation or co-precipitation of radionuclide-bearing solid phases (solubility limits), complexation in solution, sorption onto surfaces, colloid formation, and diffusion. There may be many scenarios that could affect the near-field environment, creating chemical conditions more aggressive than the conditions presented by the unperturbed system (such as pH changes beyond the range of 6 to 9 or significant changes in the ionic strength of infiltrated waters). For an extended period of time, the near-field water composition may be quite different and more extreme in pH, ionic strength, and CO{sub 2} partial pressure (or carbonate concentration) than waters at some distance from the repository. Reducing conditions, high pH (up to 11), and low carbonate concentration may be present in the near-field after reaction of infiltrating groundwater with engineered barrier systems, such as cementitious materials. In the far-field, conditions are controlled by the rock-mass buffer providing a near-neutral, oxidizing, low-ionic-strength environment that controls radionuclide solubility limits and sorption capacities. There is the need for characterization of variable chemical conditions that affect solubility, speciation, and sorption reactions. Modeling of the groundwater chemistry is required and leads to an understanding of solubility and speciation of the important radionuclides. Because experimental studies cannot be performed under the numerous potential chemical conditions, solubility limitations must rely on geochemical modeling of the radionuclide's chemistry. Fundamental thermodynamic properties, such as solubility

  3. Limits to Drift Chamber Resolution

    CERN Document Server

    Riegler, Werner

    1998-01-01

    ATLAS (A Large Toroidal LHC Apparatus) will be a general-purpose experiment at the Large Hadron Collider that will be operational at CERN in the year 2004. The ATLAS muon spectrometer aims for a momentum resolution of 10% for a transverse momentum of pT=1TeV. The precision tracking devices in the muon system will be high pressure drift tubes (MDTs) with a single wire resolution of 1100 chambers covering an area of ≈ 2500m2. The high counting rates in the spectrometer as well as the aim for excellent spatial resolution and high efficiency put severe constraints on the MDT operating parameters. This work describes a detailed study of all the resolution limiting factors in the ATLAS environment. A ’full chain’ simulation of the MDT response to photons and charged particles as well as quantitative comparisons with measurements was performed. The good agreement between simulation and measurements resulted in a profound understanding of the drift chamber processes and the individual contributions to the spat...

  4. Shear wall ultimate drift limits

    Energy Technology Data Exchange (ETDEWEB)

    Duffey, T.A. [Duffy, (T.A.) Tijeras, NM (United States); Goldman, A. [Goldman, (A.), Sandia, Los Alamos, NM (United States); Farrar, C.R. [Los Alamos National Lab., NM (United States)

    1994-04-01

    Drift limits for reinforced-concrete shear walls are investigated by reviewing the open literature for appropriate experimental data. Drift values at ultimate are determined for walls with aspect ratios ranging up to a maximum of 3.53 and undergoing different types of lateral loading (cyclic static, monotonic static, and dynamic). Based on the geometry of actual nuclear power plant structures exclusive of containments and concerns regarding their response during seismic (i.e.,cyclic) loading, data are obtained from pertinent references for which the wall aspect ratio is less than or equal to approximately 1, and for which testing is cyclic in nature (typically displacement controlled). In particular, lateral deflections at ultimate load, and at points in the softening region beyond ultimate for which the load has dropped to 90, 80, 70, 60, and 50 percent of its ultimate value, are obtained and converted to drift information. The statistical nature of the data is also investigated. These data are shown to be lognormally distributed, and an analysis of variance is performed. The use of statistics to estimate Probability of Failure for a shear wall structure is illustrated.

  5. Characteristic limits of two dosimetric systems used in individual monitoring; Limites caracteristicos de dois sistemas dosimetricos utilizados em monitoracao individual

    Energy Technology Data Exchange (ETDEWEB)

    Meireles, L.S.; Meira-Belo, L.C.; Lacerda, M.A.S., E-mail: masl@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Oliveira, P.M.C. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (Brazil)

    2014-07-01

    The characteristic limits: Decision Threshold (y⁎*), Detection Limit (y⧣) and Limits of the Confidence Interval ( y ⊲ and y⊳), were determined for two TLD-100 dosimetric systems, used for individual monitoring. We perform a critical analysis of the suitability of utilizing a dosimetric system for low dose range applications, based on these characteristic values. (author)

  6. Material limitations on the detection limit in refractometry.

    Science.gov (United States)

    Skafte-Pedersen, Peder; Nunes, Pedro S; Xiao, Sanshui; Mortensen, Niels Asger

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η, with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window (λ ≳ 1100 nm) of silicon the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because the silicon absorbs strongly.

  7. Material Limitations on the Detection Limit in Refractometry

    CERN Document Server

    Skafte-Pedersen, Peder; Xiao, Sanshui; Mortensen, Niels Asger; 10.3390/s91108382

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min{Dn} > eta with n+i*eta being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window of silicon the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because silicon absorbs strongly.

  8. Material Limitations on the Detection Limit in Refractometry

    Directory of Open Access Journals (Sweden)

    Niels Asger Mortensen

    2009-10-01

    Full Text Available We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window (λ ≳ 1100 nm of silicon the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because the silicon absorbs strongly.

  9. Material limitations on the detection limit in refractometry

    DEFF Research Database (Denmark)

    Skafte-Pedersen, Peder; Nunes, Pedro; Xiao, Sanshui

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors...... and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window (λ ≳ 1100 nm) of silicon...... the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because the silicon absorbs strongly....

  10. Astronomical Limiting Magnitude at Langkawi Observatory

    Science.gov (United States)

    Zainuddin, Mohd. Zambri; Loon, Chin Wei; Harun, Saedah

    2010-07-01

    Astronomical limiting magnitude is an indicator for astronomer to conduct astronomical measurement at a particular site. It gives an idea to astronomer of that site what magnitude of celestial object can be measured. Langkawi National Observatory (LNO) is situated at Bukit Malut with latitude 6°18' 25'' North and longitude 99°46' 52'' East in Langkawi Island. Sky brightness measurement has been performed at this site using the standard astronomical technique. The value of the limiting magnitude measured is V = 18.6+/-1.0 magnitude. This will indicate that astronomical measurement at Langkawi observatory can only be done for celestial objects having magnitude less than V = 18.6 magnitudes.

  11. Controlled Limiter in the Synchronous Detection Circuit

    Directory of Open Access Journals (Sweden)

    Yauheni Bialetski

    2017-07-01

    Full Text Available This variant of construction of the electrical circuit is aimed at reducing the effects of impulse noise. The measuring channels of the primary transducers are subject to interference of various types. In the case of a small ratio between a useful signal and noise level, synchronous detection is used. Impulse noise leaves a big mark even after using synchronous detection. To improve the performance of such measuring devices, it is proposed to use a controlled amplitude limiter at the input. Comparative analysis of solutions with controlled limiters is carried out in the article and conditions for its optimal operation are determined.

  12. Material Limitations on the Detection Limit in Refractometry

    OpenAIRE

    Niels Asger Mortensen; Sanshui Xiao; Peder Skafte-Pedersen; Nunes, Pedro S.

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η, with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in ...

  13. Limited data speaker identification

    Indian Academy of Sciences (India)

    H S Jayanna; S R Mahadeva Prasanna

    2010-10-01

    In this paper, the task of identifying the speaker using limited training and testing data is addressed. Speaker identification system is viewed as four stages namely, analysis, feature extraction, modelling and testing. The speaker identification performance depends on the techniques employed in these stages. As demonstrated by different experiments, in case of limited training and testing data condition, owing to less data, existing techniques in each stage will not provide good performance. This work demonstrates the following: multiple frame size and rate (MFSR) analysis provides improvement in the analysis stage, combination of mel frequency cepstral coefficients (MFCC), its temporal derivatives $(\\Delta,\\Delta \\Delta)$, linear prediction residual (LPR) and linear prediction residual phase (LPRP) features provides improvement in the feature extraction stage and combination of learning vector quantization (LVQ) and gaussian mixture model – universal background model (GMM–UBM) provides improvement in the modelling stage. The performance is further improved by integrating the proposed techniques at the respective stages and combining the evidences from them at the testing stage. To achieve this, we propose strength voting (SV), weighted borda count (WBC) and supporting systems (SS) as combining methods at the abstract, rank and measurement levels, respectively. Finally, the proposed hierarchical combination (HC) method integrating these three methods provides significant improvement in the performance. Based on these explorations, this work proposes a scheme for speaker identification under limited training and testing data.

  14. Determination of the Limiting Magnitude

    Science.gov (United States)

    Kingery, Aaron; Blaauw, Rhiannon

    2017-01-01

    The limiting magnitude of an optical camera system is an important property to understand since it is used to find the completeness limit of observations. Limiting magnitude depends on the hardware and software of the system, current weather conditions, and the angular speed of the objects observed. If an object exhibits a substantial angular rate during the exposure, its light spreads out over more pixels than the stationary stars. This spreading causes the limiting magnitude to be brighter when compared to the stellar limiting magnitude. The effect, which begins to become important when the object moves a full width at half max during a single exposure or video frame. For targets with high angular speeds or camera systems with narrow field of view or long exposures, this correction can be significant, up to several magnitudes. The stars in an image are often used to measure the limiting magnitude since they are stationary, have known brightness, and are present in large numbers, making the determination of the limiting magnitude fairly simple. In order to transform stellar limiting magnitude to object limiting magnitude, a correction must be applied accounting for the angular velocity. This technique is adopted in meteor and other fast-moving object observations, as the lack of a statistically significant sample of targets makes it virtually impossible to determine the limiting magnitude before the weather conditions change. While the weather is the dominant factor in observing satellites, the limiting magnitude for meteors also changes throughout the night due to the motion of a meteor shower or sporadic source radiant across the sky. This paper presents methods for determining the limiting stellar magnitude and the conversion to the target limiting magnitude.

  15. Performance, Performance System, and High Performance System

    Science.gov (United States)

    Jang, Hwan Young

    2009-01-01

    This article proposes needed transitions in the field of human performance technology. The following three transitions are discussed: transitioning from training to performance, transitioning from performance to performance system, and transitioning from learning organization to high performance system. A proposed framework that comprises…

  16. DISCUSSION ON DECISION LIMIT AND DETECTION LIMIT IN SPECTROSCOPY

    Institute of Scientific and Technical Information of China (English)

    郑仁圻; 余君岳; 等

    1995-01-01

    Based on fundamental arguments,the expressions for the decision limit and the detection limit both in the count domain and in the cout rate domain are derive4d.These expressions are found to be different from those shown in the existing literature.

  17. Welfare Dynamics under Time Limits

    OpenAIRE

    Jeff Grogger; Charles Michalopoulos

    2003-01-01

    Among the most important changes brought about by the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA) is the imposition of time limits. In this paper, we analyze a simple model in which a potential welfare recipient chooses how to allocate her time-limited endowment of benefits so as to maximize her expected lifetime utility. Not surprisingly, the model reveals that time limits provide an incentive for the consumer to conserve, or bank, her benefits. More inte...

  18. Optimum shapes for pump limiters

    Energy Technology Data Exchange (ETDEWEB)

    Ulrickson, M.

    1982-05-01

    The design of a pump limiter depends strongly on the details of the plasma scrapeoff zone. A model has been developed which allows the transport coefficients in the scrapeoff to be functions of n and t. This model has been used to predict scrapeoff profiles for FED/INTOR. The profiles are used to find and analyze limiter profiles. The results suggest the use of limiter shapes which curve toward the plasma.

  19. Internal polarization limits coronagraph contrast

    Science.gov (United States)

    Breckinridge, James Bernard; Lam, Wai Sze T.; Chipman, Russell A.

    2015-08-01

    The performance of exoplanet imaging coronagraphs is limited by internal polarization. The point spread function (PSF) of these systems is determined by the details of the opto-mechanical layout selected to package the system and by the highly reflective metal thin films needed to maintain high optical system transmittance. To obtain the high contrast levels needed for terrestrial exoplanet science requires a comprehensive understanding of the vector electromagnetic wave from the source through the system. The literature contains many studies of polarization transmissivity of telescopes and instruments for the purpose of photo-polarimetry. Here we report for the first time the effects of polarization on high-performance image quality.We modeled a typical 2.4-meter Cassegrain telescope system with one 90-degree fold mirror and analyzed the system for polarization aberrations.We find: 1. The image plane irradiance distribution is the linear superposition of four PSF images: One for each of the two orthogonal polarizations and one for each of two cross-product polarization terms. 2. The PSF image is brighter by 9% for one polarization component compared to its orthogonal state. 3. The image of the PSF for orthogonal components are shifted across the focal plane with respect to each other, causing the PSF image for astronomical sources (polarized or unpolarized) to become slightly elongated (elliptical) with a centroid separation of about 0.6 masec. 4. The orthogonally polarized components of unpolarized sources contain different wavefront aberrations, which are separated by approximately 32 milliwaves. This implies that a wavefront correction system cannot optimally correct the aberrations for all polarizations simultaneously. 5. The polarization aberrations couple small parts (~1E-5) of each polarization component of the light into the orthogonal polarization to create highly distorted secondary, or “ghost” PSF image.. The radius of the spatial extent of the 90

  20. The Augmented Performer and the Performative Augmentation

    DEFF Research Database (Denmark)

    Kallionpaa, Maria; Gasselseder, Hans-Peter

    2016-01-01

    Composers, performers, and listeners usually regard musical compositions as unchangeable entities, which limits the composition techniques and decreases the originality of performers ́ interpretations, thus leading to a stagnation of classical music culture. The significance and possibilities of ...... help to widen the horizons of classical music. Developing new innovative tools and methodologies would also benefit game designers and music educators.......Composers, performers, and listeners usually regard musical compositions as unchangeable entities, which limits the composition techniques and decreases the originality of performers ́ interpretations, thus leading to a stagnation of classical music culture. The significance and possibilities...... of interactive music systems have been widely recognised in the context of modern computer games. The concept of procedural music challenges the idea of a composition as a fixed formula. Similar to a computer game, a music score based on such techniques can take a plethora of unpredictable turns depending...

  1. Limit cycles in quantum systems

    Energy Technology Data Exchange (ETDEWEB)

    Niemann, Patrick

    2015-04-27

    In this thesis we investigate Limit Cycles in Quantum Systems. Limit cycles are a renormalization group (RG) topology. When degrees of freedom are integrated out, the coupling constants flow periodically in a closed curve. The presence of limit cycles is restricted by the necessary condition of discrete scale invariance. A signature of discrete scale invariance and limit cycles is log-periodic behavior. The first part of this thesis is concerned with the study of limit cycles with the similarity renormalization group (SRG). Limit cycles are mainly investigated within conventional renormalization group frameworks, where degrees of freedom, which are larger than a given cutoff, are integrated out. In contrast, in the SRG potentials are unitarily transformed and thereby obtain a band-diagonal structure. The width of the band structure can be regarded as an effective cutoff. We investigate the appearance of limit cycles in the SRG evolution. Our aim is to extract signatures as well as the scaling factor of the limit cycle. We consider the 1/R{sup 2}-potential in a two-body system and a three-body system with large scattering lengths. Both systems display a limit cycle. Besides the frequently used kinetic energy generator we apply the exponential and the inverse generator. In the second part of this thesis, Limit Cycles at Finite Density, we examine the pole structure of the scattering amplitude for distinguishable fermions at zero temperature in the medium. Unequal masses and a filled Fermi sphere for each fermion species are considered. We focus on negative scattering lengths and the unitary limit. The properties of the three-body spectrum in the medium and implications for the phase structure of ultracold Fermi gases are discussed.

  2. Performing Nation, Performing Difference

    DEFF Research Database (Denmark)

    Jensen, Lars

    , or nation building, on the one side and the stark historical realism of the stolen generations + the backdrop of the second world war bombing of Darwin by the Japanese collectively creates a number of interwoven narratives in the tapestry that forms Australian cultural history.......Baz Luhrmann's Australia is simultaneously a film made for an Australian and an international audience. One of the interesting question this raises is how Luhrmann performs the nation for the national and the international audience. The film's juxtaposition of the national epic of pioneering...

  3. Chunk Limits and Length Limits in Immediate Recall: A Reconciliation

    Science.gov (United States)

    Chen, Zhijian; Cowan, Nelson

    2008-01-01

    Whereas some research on immediate recall of verbal lists has suggested that it is limited by the number of chunks that can be recalled (e.g., Tulving & Patkau, 1962; Cowan, Chen, & Rouder, 2004), other research has suggested that it is limited by the length of the material to be recalled (e.g., Baddeley, Thomson, & Buchanan, 1975). We investigated this question by teaching new paired associations between words to create two-word chunks. The results suggest that both chunk capacity limits and length limits come into play. For the free recall of 12-word lists, 6 pre-learned pairs could be recalled about as well as 6 pre-exposed singletons, suggesting a chunk limit. However, for the serially-ordered recall of 8-word lists, 4 pre-learned pairs could be recalled about as well as 8 pre-exposed singletons, suggesting a length limit. Other conditions yielded intermediate results suggesting that sometimes both limits may operate together. PMID:16393043

  4. Selection by pairwise comparisons with limited resources

    Science.gov (United States)

    Laureti, Paolo; Mathiesen, Joachim; Zhang, Yi-Cheng

    2004-07-01

    We analyze different methods of sorting and selecting a set of objects by their intrinsic value, via pairwise comparisons whose outcome is uncertain. After discussing the limits of repeated Round Robins, two new methods are presented: The ran-fil requires no previous knowledge on the set under consideration, yet displaying good performances even in the least favorable case. The min-ent method sets a benchmark for optimal dynamic tournaments design.

  5. Resolution-limited statistical image classification

    Science.gov (United States)

    Elbaum, Marek; Syrkin, Mark

    1993-09-01

    We have examined the performance of a one-layer Perceptron for the detection and classification of small (resolution-limited) targets from their images, which are stochastic realizations of random processes. The processes are governed by non-Gaussian, non-white distributions. Our results show the potential of the Perceptron classifier as an Ideal Observer and suggest image detection and classification problems for which neural networks may be more reliable than human observers.

  6. Method for Predicting Hypergolic Mixture Flammability Limits

    Science.gov (United States)

    2017-02-01

    AFRL-AFOSR-UK-TR-2017-0003 Method for Predicting Hypergolic Mixture Flammability Limits Laurent Catoire Ecole Nat Sup De Techniques Avancees Final...TASK NUMBER 5f.  WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Ecole Nat Sup De Techniques Avancees 828, Boulevard Des Marechaux...provides a mitigation strategy to reduce the risk of failure for the insertion of IL fuel technology into the small satellite market as AFRL/RQRP

  7. LimitS - A system for limit state analysis and optimal material layout

    DEFF Research Database (Denmark)

    Damkilde, Lars; Krenk, Steen

    1997-01-01

    A system LimitS for limit state analysis and material optimization has been developed and implemented in a PC environment. The program is formulated in a general finite element format with stress-based elements. The solution method is based on the lower-bound theorem, where an optimal stress...... the statics and kinematics of the collapse mode are determined via the dual variables of the LP-problem. In LimitS the following element types are implemented: two- and three-dimensional beam elements; truss elements; triangular slab elements; and shear and stringer elements for plates with in-plane loading....... Examples of all three problem types are given including both limit state analysis and material optimization....

  8. LimitS - A system for limit state analysis and optimal material layout

    DEFF Research Database (Denmark)

    Damkilde, Lars; Krenk, Steen

    1997-01-01

    A system LimitS for limit state analysis and material optimization has been developed and implemented in a PC environment. The program is formulated in a general finite element format with stress-based elements. The solution method is based on the lower-bound theorem, where an optimal stress...... the statics and kinematics of the collapse mode are determined via the dual variables of the LP-problem. In LimitS the following element types are implemented: two- and three-dimensional beam elements; truss elements; triangular slab elements; and shear and stringer elements for plates with in-plane loading....... Examples of all three problem types are given including both limit state analysis and material optimization....

  9. Solubility limits on radionuclide dissolution

    Energy Technology Data Exchange (ETDEWEB)

    Kerrisk, J.F.

    1984-12-31

    This paper examines the effects of solubility in limiting dissolution rates of a number of important radionuclides from spent fuel and high-level waste. Two simple dissolution models were used for calculations that would be characteristics of a Yucca Mountain repository. A saturation-limited dissolution model, in which the water flowing through the repository is assumed to be saturated with each waste element, is very conservative in that it overestimates dissolution rates. A diffusion-limited dissolution model, in which element-dissolution rates are limited by diffusion of waste elements into water flowing past the waste, is more realistic, but it is subject to some uncertainty at this time. Dissolution rates of some elements (Pu, Am, Sn, Th, Zr, Sm) are always limited by solubility. Dissolution rates of other elements (Cs, Tc, Np, Sr, C, I) are never solubility limited; their release would be limited by dissolution of the bulk waste form. Still other elements (U, Cm, Ni, Ra) show solubility-limited dissolution under some conditions. 9 references, 3 tables.

  10. Delving into Limits of Sequences

    Science.gov (United States)

    Cory, Beth; Smith, Ken W.

    2011-01-01

    Limits are foundational to the central concepts of calculus. However, the authors' experiences with students and educational research abound with examples of students' misconceptions about limits and infinity. The authors wanted calculus students to understand, appreciate, and enjoy their first introduction to advanced mathematical thought. Thus,…

  11. Delving into Limits of Sequences

    Science.gov (United States)

    Cory, Beth; Smith, Ken W.

    2011-01-01

    Limits are foundational to the central concepts of calculus. However, the authors' experiences with students and educational research abound with examples of students' misconceptions about limits and infinity. The authors wanted calculus students to understand, appreciate, and enjoy their first introduction to advanced mathematical thought. Thus,…

  12. Beam-limiting and radiation-limiting interlocks

    Energy Technology Data Exchange (ETDEWEB)

    Macek, R.J.

    1996-04-01

    This paper reviews several aspects of beam-limiting and radiation- limiting interlocks used for personnel protection at high-intensity accelerators. It is based heavily on the experience at the Los Alamos Neutron Science Center (LANSCE) where instrumentation-based protection is used extensively. Topics include the need for ``active`` protection systems, system requirements, design criteria, and means of achieving and assessing acceptable reliability. The experience with several specific devices (ion chamber-based beam loss interlock, beam current limiter interlock, and neutron radiation interlock) designed and/or deployed to these requirements and criteria is evaluated.

  13. Force Limited Vibration Testing Monograph

    Science.gov (United States)

    Scharton, Terry D.

    1997-01-01

    The practice of limiting the shaker force in vibration tests was investigated at the NASA Jet Propulsion Laboratory (JPL) in 1990 after the mechanical failure of an aerospace component during a vibration test. Now force limiting is used in almost every major vibration test at JPL and in many vibration tests at NASA Goddard Space Flight Center (GSFC) and at many aerospace contractors. The basic ideas behind force limiting have been in the literature for several decades, but the piezo-electric force transducers necessary to conveniently implement force limiting have been available only in the last decade. In 1993, funding was obtained from the NASA headquarters Office of Chief Engineer to develop and document the technology needed to establish force limited vibration testing as a standard approach available to all NASA centers and aerospace contractors. This monograph is the final report on that effort and discusses the history, theory, and applications of the method in some detail.

  14. Performance Poolsheet

    Data.gov (United States)

    US Agency for International Development — The Performance Poolsheet is an MS Access database that captures performance appraisal data for employees eligible for performance awards. Microsoft Access database...

  15. Chunk Limits and Length Limits in Immediate Recall: A Reconciliation

    Science.gov (United States)

    Chen, Zhijian; Cowan, Nelson

    2005-01-01

    Whereas some research on immediate recall of verbal lists has suggested that it is limited by the number of chunks that can be recalled (e.g., N. Cowan, Z. Chen, & J. N. Rouder, 2004; E. Tulving & J. E. Patkau, 1962), other research has suggested that it is limited by the length of the material to be recalled (e.g., A. D. Baddeley, N. Thomson, &…

  16. Physical limits in semiconductor electronics.

    Science.gov (United States)

    Keyes, R W

    1977-03-18

    Although the limitations of the methods of lithography in use at a particular time are easily recognized and attract substantial attention, experience shows that technological ingenuity keeps pushing them to ever-smaller dimensions. There seems to be no fundamental reason to expect that lithographic limits will not continue to recede. The limits to the advance of miniaturization are to be found in the ability of materials to withstand high electric fields and in the ability of packaging technology to remove heat from active components and provide for power distribution, signal interconnection, and flexible mechanical assembly.

  17. The Limits to Giving Back

    Directory of Open Access Journals (Sweden)

    Jade S. Sasser

    2014-07-01

    Full Text Available In this thematic section, authors consider the limitations on giving back that they faced in field research, or saw others face. For some authors, their attempts at giving back were severely limited by the scope of their projects, or their understandings of local cultures or histories. For others, very specific circumstances and historical interventions of foreigners in certain places can limit how and to what extent a researcher is able to have a reciprocal relationship with the participating community. Some authors, by virtue of their lesser positions of power relative to those that they were studying, simply decided not to give back to those communities. In each article it becomes apparent that how and in what ways people give back is unique (and limited both to their personal values and the contexts in which they do research.

  18. OECD Maximum Residue Limit Calculator

    Science.gov (United States)

    With the goal of harmonizing the calculation of maximum residue limits (MRLs) across the Organisation for Economic Cooperation and Development, the OECD has developed an MRL Calculator. View the calculator.

  19. Multifamily Tax Subsidy Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — Multifamily Tax Subsidy Projects (MTSP) Income Limits were developed to meet the requirements established by the Housing and Economic Recovery Act of 2008 (Public...

  20. Limits of Kansei - Kansei unlimited

    OpenAIRE

    BONGARD-BLANCHY, Kerstin; Bouchard, Carole; AOUSSAT, Améziane

    2013-01-01

    International audience; This article discusses momentary limitations of the Kansei Engineering methods. There are for example the focus on the evaluation of colour and form factors, as well as the highly time consuming creation of the questionnaires. To overcome these limits we firstly suggest the integration of word lists from related research fields, like sociology and cognitive psychology on product emotions in the Kansei questionnaires. Thereafter we present a study on the wide range of K...

  1. Limit cycle vibrations in turbomachinery

    Science.gov (United States)

    Ryan, S. G.

    1991-01-01

    The focus is on an examination of rotordynamic systems which are simultaneously susceptible to limit cycle instability and subharmonic response. Characteristics of each phenomenon are determined as well as their interrelationship. A normalized, single mass rotor model is examined as well as a complex model of the high pressure fuel turbopump and the Space Shuttle Main Engine. Entrainment of limit cycle instability by subharmonic response is demonstrated for both models. The nonuniqueness of the solution is also demonstrated.

  2. Fundamental limits of positron emission mammography

    Energy Technology Data Exchange (ETDEWEB)

    Moses, William W.; Qi, Jinyi

    2001-06-01

    We explore the causes of performance limitation in positron emission mammography cameras. We compare two basic camera geometries containing the same volume of 511 keV photon detectors, one with a parallel plane geometry and another with a rectangular geometry. We find that both geometries have similar performance for the phantom imaged (in Monte Carlo simulation), even though the solid angle coverage of the rectangular camera is about 50 percent higher than the parallel plane camera. The reconstruction algorithm used significantly affects the resulting image; iterative methods significantly outperform the commonly used focal plane tomography. Finally, the characteristics of the tumor itself, specifically the absolute amount of radiotracer taken up by the tumor, will significantly affect the imaging performance.

  3. Optimal Control Design with Limited Model Information

    CERN Document Server

    Farokhi, F; Johansson, K H

    2011-01-01

    We introduce the family of limited model information control design methods, which construct controllers by accessing the plant's model in a constrained way, according to a given design graph. We investigate the achievable closed-loop performance of discrete-time linear time-invariant plants under a separable quadratic cost performance measure with structured static state-feedback controllers. We find the optimal control design strategy (in terms of the competitive ratio and domination metrics) when the control designer has access to the local model information and the global interconnection structure of the plant-to-be-controlled. At last, we study the trade-off between the amount of model information exploited by a control design method and the best closed-loop performance (in terms of the competitive ratio) of controllers it can produce.

  4. Error analysis of flux limiter schemes at extrema

    Science.gov (United States)

    Kriel, A. J.

    2017-01-01

    Total variation diminishing (TVD) schemes have been an invaluable tool for the solution of hyperbolic conservation laws. One of the major shortcomings of commonly used TVD methods is the loss of accuracy near extrema. Although large amounts of anti-diffusion usually benefit the resolution of discontinuities, a balanced limiter such as Van Leer's performs better at extrema. Reliable criteria, however, for the performance of a limiter near extrema are not readily apparent. This work provides theoretical quantitative estimates for the local truncation errors of flux limiter schemes at extrema for a uniform grid. Moreover, the component of the error attributed to the flux limiter was obtained. This component is independent of the problem and grid spacing, and may be considered a property of the limiter that reflects the performance at extrema. Numerical test problems validate the results.

  5. Approaching the Landauer limit via nanomechanical resonators

    Science.gov (United States)

    Wenzler, Josef-Stefan

    According to the von Neumann-Landauer principle (VNL) for every bit of information lost during a computation, kT In 2 amount of heat is dissipated into the environment. Irreversible logic, the basis of modern computing, inevitably leads to loss of information and is thus fundamentally bound by the VNL principle. However, its validity has been challenged since its inception and the case concerning its legitimacy is still open. Due to the tiny energy scales involved, this debate has been entirely academic in nature and an experimental test of the VNL principle is highly desired by both proponents and skeptics. Such a test would entail contrasting the energy dissipation of irreversible and reversible logic. In particular, we need to perform a non trivial logic both reversibly and irreversibly based on identical technology, testing whether or not energy dissipation for the reversible computation can be less than VNL limit while the irreversible computation is limited by the VNL limit Reversible logic does not entail information loss, and hence is not bound by the VNL limit. It offers the potential for indefinite performance improvements of digital electronics. Bennett's Turing machine first proved that any computation can be performed reversibly and, in the proper limit, without energy cost. This promise of computing for free has spurred Fredkin, Toffoli, Wilczek, Feynman and others to propose reversible logic gates, though very few experimentally- realized reversible logic gates have since been reported. Here, we experimentally demonstrate for the first time the core of a logically reversible, CMOS-compatible, scalable nanoelectromechanical Fredkin gate, a universal logic gate from which any reversible computation can be built. In addition to demonstrating the truth table, we show that the nanomechanical Fredkin gate can be operated as a reversible AND-, OR-, NOT- and FANOUT gate. We find that this device exhibits ultra-low energy cost per logic operation, on the

  6. Comparison among tomographic reconstruction with limited data

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Eric F.; Dantas, Carlos C.; Vasconcelos, Daniel A.A.; Cadiz, Luis F., E-mail: ccd@ufpe.br [Department of Nuclear Energy (DEN). Federal University of Pernambuco (UFPE), Recife, PE (Brazil); Melo, Silvio B., E-mail: sbm@cin.ufpe.br [Informatic Center (CIN), Federal University of Pernambuco (UFPE), Recife, PE (Brazil)

    2011-07-01

    Nowadays there is a continuing interest in applying computed tomography (CT) techniques in non-destructive testing and inspection of many industrial products. These applications of CT usually require a differentiated analysis when there are strong limitations in acquiring a sufficiently large amount of projection data. The use of a low number of tomographic data normally degrades the quality of the reconstructed image, highlighting the formation of artifacts and noise. This work investigates the reconstruction methods most commonly used (FBP, ART, SIRT, MART, SMART) and shows the performance of each one in this limited scenario. For this purpose, all methods were implemented and tested with a phantom of uniform density with well-known distribution, with measures of transmission of gamma radiation in a first generation CT scanner. The phantom is a concentric stainless steel tube coupled with a half - cylinder of aluminum. The measurements were made with an highest root mean square error, with the formation of visible artifacts. The artifacts are diminished but still visible in the ART and SIRT techniques, and the best performance was observed with the techniques MART and SMART. The technical superiority of these multiplicative methods is clearly seen in the reconstructed image quality, endorsing their application to situations of limited input data. (author)

  7. Time-limited optimal dynamics beyond the Quantum Speed Limit

    DEFF Research Database (Denmark)

    Gajdacz, Miroslav; Das, Kunal K.; Arlt, Jan

    2015-01-01

    -off expressed in terms of the direct Hilbert velocity provides a robust prediction of the quantum speed limit and allows to adapt the control optimization such that it yields a predefined fidelity. The results are verified numerically in a multilevel system with a constrained Hamiltonian, and a classification......The quantum speed limit sets the minimum time required to transfer a quantum system completely into a given target state. At shorter times the higher operation speed has to be paid with a loss of fidelity. Here we quantify the trade-off between the fidelity and the duration in a system driven...

  8. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    NA

    2004-11-22

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this modeling activity is to predict dissolved concentrations or solubility limits for 14 elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) important to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are in the form of tabulated functions with pH and log (line integral) CO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. The output data from this report are fundamental inputs for Total System Performance Assessment for the License Application (TSPA-LA) to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for all of the actinides. These models cover broad ranges of environmental conditions so that they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or otherwise addressed.

  9. Photosynthesis limitations in three fern species.

    Science.gov (United States)

    Gago, Jorge; Coopman, Rafael E; Cabrera, Hernán Marino; Hermida, Carmen; Molins, Arántzazu; Conesa, Miquel À; Galmés, Jeroni; Ribas-Carbó, Miquel; Flexas, Jaume

    2013-12-01

    Maximum photosynthesis rates in ferns are generally lower than those of seed plants, but little is known about the limiting factors, which are crucial to understand the evolution of photosynthesis in land plants. To address this issue, a gas exchange/chlorophyll fluorescence analysis was performed in three fern species spanning high phylogenetic range within Polypodiopsida (Osmunda regalis, Blechnum gibbum and Nephrolepis exaltata) to determine their maximum net photosynthesis (AN ), stomatal (gs ) and mesophyll (gm ) conductances to CO2 , and the maximum velocity of carboxylation (Vc,max ). The in vitro Rubisco specificity factor (SC /O ) was also determined. All three species had values for SC /O similar to those typical of seed plants, but values of AN , gs , gm and Vc,max were within the lowest range of those observed in seed plants. In addition, gs was unresponsive to light and CO2 , as already described in other fern species. On the contrary, gm varied with changes CO2 . A quantitative photosynthesis limitation analysis suggested that early land plants (ferns) presented not only stomatal limitations-which were less adjustable to the environment-but also restricted gm and Vc,max , resulting in limited maximum photosynthesis rates.

  10. Practical roadmap and limits to nanostructured photovoltaics.

    Science.gov (United States)

    Lunt, Richard R; Osedach, Timothy P; Brown, Patrick R; Rowehl, Jill A; Bulović, Vladimir

    2011-12-22

    The significant research interest in the engineering of photovoltaic (PV) structures at the nanoscale is directed toward enabling reductions in PV module fabrication and installation costs as well as improving cell power conversion efficiency (PCE). With the emergence of a multitude of nanostructured photovoltaic (nano-PV) device architectures, the question has arisen of where both the practical and the fundamental limits of performance reside in these new systems. Here, the former is addressed a posteriori. The specific challenges associated with improving the electrical power conversion efficiency of various nano-PV technologies are discussed and several approaches to reduce their thermal losses beyond the single bandgap limit are reviewed. Critical considerations related to the module lifetime and cost that are unique to nano-PV architectures are also addressed. The analysis suggests that a practical single-junction laboratory power conversion efficiency limit of 17% and a two-cell tandem power conversion efficiency limit of 24% are possible for nano-PVs, which, when combined with operating lifetimes of 10 to 15 years, could position them as a transformational technology for solar energy markets.

  11. The ODELIA Study on Noise Limits for Outdoor Machinery

    NARCIS (Netherlands)

    Dittrich, M.G.; Carletti, E.; Spellerberg, G.

    2016-01-01

    In the ODELIA study for the European Commission an assessment of the outdoor equipment noise directive 2000/14/EC and its amendment 2005/88/EC has been performed. The directive requires noise marking for 57 types of equipment used outdoors, and sets noise limits for 22 of these. Since the limits

  12. Generalized Geometric Quantum Speed Limits

    Science.gov (United States)

    Pires, Diego Paiva; Cianciaruso, Marco; Céleri, Lucas C.; Adesso, Gerardo; Soares-Pinto, Diogo O.

    2016-04-01

    The attempt to gain a theoretical understanding of the concept of time in quantum mechanics has triggered significant progress towards the search for faster and more efficient quantum technologies. One of such advances consists in the interpretation of the time-energy uncertainty relations as lower bounds for the minimal evolution time between two distinguishable states of a quantum system, also known as quantum speed limits. We investigate how the nonuniqueness of a bona fide measure of distinguishability defined on the quantum-state space affects the quantum speed limits and can be exploited in order to derive improved bounds. Specifically, we establish an infinite family of quantum speed limits valid for unitary and nonunitary evolutions, based on an elegant information geometric formalism. Our work unifies and generalizes existing results on quantum speed limits and provides instances of novel bounds that are tighter than any established one based on the conventional quantum Fisher information. We illustrate our findings with relevant examples, demonstrating the importance of choosing different information metrics for open system dynamics, as well as clarifying the roles of classical populations versus quantum coherences, in the determination and saturation of the speed limits. Our results can find applications in the optimization and control of quantum technologies such as quantum computation and metrology, and might provide new insights in fundamental investigations of quantum thermodynamics.

  13. Generalized Geometric Quantum Speed Limits

    Directory of Open Access Journals (Sweden)

    Diego Paiva Pires

    2016-06-01

    Full Text Available The attempt to gain a theoretical understanding of the concept of time in quantum mechanics has triggered significant progress towards the search for faster and more efficient quantum technologies. One of such advances consists in the interpretation of the time-energy uncertainty relations as lower bounds for the minimal evolution time between two distinguishable states of a quantum system, also known as quantum speed limits. We investigate how the nonuniqueness of a bona fide measure of distinguishability defined on the quantum-state space affects the quantum speed limits and can be exploited in order to derive improved bounds. Specifically, we establish an infinite family of quantum speed limits valid for unitary and nonunitary evolutions, based on an elegant information geometric formalism. Our work unifies and generalizes existing results on quantum speed limits and provides instances of novel bounds that are tighter than any established one based on the conventional quantum Fisher information. We illustrate our findings with relevant examples, demonstrating the importance of choosing different information metrics for open system dynamics, as well as clarifying the roles of classical populations versus quantum coherences, in the determination and saturation of the speed limits. Our results can find applications in the optimization and control of quantum technologies such as quantum computation and metrology, and might provide new insights in fundamental investigations of quantum thermodynamics.

  14. Why Property Tax Limitations Won't Limit Everyone's Taxes.

    Science.gov (United States)

    Picus, Larry

    Property tax limitation measures passed in 1978 by voters in California and Idaho contain provisions that apparently will reduce the equity of the property tax system in both states. Changes in assessment practices mandated by the new laws will shift the property tax burden away from business and commercial property and toward residential property…

  15. An Experiment on the Limits of Quantum Electro-dynamics

    Science.gov (United States)

    Barber, W. C.; Richter, B.; Panofsky, W. K. H.; O'Neill, G. K.; Gittelman, B.

    1959-06-01

    The limitations of previously performed or suggested electrodynamic cutoff experiments are reviewed, and an electron-electron scattering experiment to be performed with storage rings to investigate further the limits of the validity of quantum electrodynamics is described. The foreseen experimental problems are discussed, and the results of the associated calculations are given. The parameters and status of the equipment are summarized. (D.C.W.)

  16. Limited Feedback Precoding for Massive MIMO

    Directory of Open Access Journals (Sweden)

    Xin Su

    2013-01-01

    Full Text Available The large-scale array antenna system with numerous low-power antennas deployed at the base station, also known as massive multiple-input multiple-output (MIMO, can provide a plethora of advantages over the classical array antenna system. Precoding is important to exploit massive MIMO performance, and codebook design is crucial due to the limited feedback channel. In this paper, we propose a new avenue of codebook design based on a Kronecker-type approximation of the array correlation structure for the uniform rectangular antenna array, which is preferable for the antenna deployment of massive MIMO. Although the feedback overhead is quite limited, the codebook design can provide an effective solution to support multiple users in different scenarios. Simulation results demonstrate that our proposed codebook outperforms the previously known codebooks remarkably.

  17. Sparse regularization in limited angle tomography

    CERN Document Server

    Frikel, Jürgen

    2011-01-01

    We investigate the reconstruction problem of limited angle tomography. Such problems arise naturally in applications like digital breast tomosynthesis, dental tomography, electron microscopy etc. Since the acquired tomographic data is highly incomplete, the reconstruction problem is severely ill-posed and the traditional reconstruction methods, such as filtered backprojection (FBP), do not perform well in such situations. To stabilize the reconstruction procedure additional prior knowledge about the unknown object has to be integrated into the reconstruction process. In this work, we propose the use of the sparse regularization technique in combination with curvelets. We argue that this technique gives rise to an edge-preserving reconstruction. Moreover, we show that the dimension of the problem can be significantly reduced in the curvelet domain. To this end, we give a characterization of the kernel of limited angle Radon transform in terms of curvelets and derive a characterization of solutions obtained thr...

  18. Intercell Interference Coordination through Limited Feedback

    Directory of Open Access Journals (Sweden)

    Lingjia Liu

    2010-01-01

    Full Text Available We consider the applications of multicell transmission schemes to the downlink of future wireless communication networks. A multicell multiple-input multiple output-(MIMOs based scheme with limited coordination among neighboring base stations (BSs is proposed to effectively combat the intercell interference by taking advantage of the degreesoffreedom in the spatial domain. In this scheme, mobile users are required to feedback channel-related information to both serving base station and interfering base station. Furthermore, a chordal distance-based compression scheme is introduced to reduce the feedback overhead. The performance of the proposed scheme is investigated through theoretical analysis as well as system level simulations. Both results suggest that the so-called “intercell interference coordination through limited feedback” scheme is a very good candidate for improving the cell-edge user throughput as well as the average cell throughput of the future wireless communication networks.

  19. Synchronized flux limiting for gas dynamics variables

    Science.gov (United States)

    Lohmann, Christoph; Kuzmin, Dmitri

    2016-12-01

    This work addresses the design of failsafe flux limiters for systems of conserved quantities and derived variables in numerical schemes for the equations of gas dynamics. Building on Zalesak's multidimensional flux-corrected transport (FCT) algorithm, we construct a new positivity-preserving limiter for the density, total energy, and pressure. The bounds for the underlying inequality constraints are designed to enforce local maximum principles in regions of strong density variations and become less restrictive in smooth regions. The proposed approach leads to closed-form expressions for the synchronized correction factors without the need to solve inequality-constrained optimization problems. A numerical study is performed for the compressible Euler equations discretized using a finite element based FCT scheme.

  20. Ultimate physical limits to computation

    CERN Document Server

    Lloyd, S

    1999-01-01

    Computers are physical systems: what they can and cannot do is dictated by the laws of physics. In particular, the speed with which a physical device can process information is limited by its energy, and the amount of information that it can process is limited by the number of degrees of freedom it possesses. The way in which it processes information is determined by the forces of nature that the computer has at its disposal. This paper explores the fundamental physical limits of computation as determined by the speed of light c, the quantum scale as given by Planck's constant h, and the gravitational constant G. As an example, quantitative bounds are put to the computational power of an `ultimate laptop' with a mass of one kilogram confined to a volume of one liter.

  1. Derived limits for surface contamination

    CERN Document Server

    Wrixon, A D; Linsley, G S; White, D F

    1979-01-01

    Derived limits (DLs) for surface contamination were first established for use in the nuclear energy industry where a wide variety of radionuclides is encountered. They were later used in factories, hospitals, and universities, where the radionuclides used are normally fewer in number, either known or readily identifiable, and often of low toxicity. In these situations the current limits are frequently over-restrictive. This report describes a reassessment of the values in the light of more recent information on the possible pathways of exposure and the dose equivalent limits given in ICRP Publication 26. The reassessment is prompted also by the introduction of SI units. The results of the reassessment are used to produce a classification of DLs for all radionuclides for active and inactive area surfaces and for skin.

  2. On Setting Limits for Supersymmetry

    Science.gov (United States)

    Simeon, Paul; Toback, David

    2004-10-01

    When searching for new particles two separate production mechanisms from the same theory may produce the same final state. For example, in gauge mediated supersymmetry breaking with \\chi^0_1arrow γ tildeG at least two production mechanisms, \\chi^0_1\\chi^±1 and \\chi^0_2\\chi^±_1, can cascade to produce events with two photons and missing transverse energy. If there is no discovery one wants to set the best possible limits. While it seems obvious that the goal is to find the lowest possible cross section limit, one should be careful and focus on excluding the largest amount of parameter space for a theory. We show that the combined cross section limit from both (or all) production mechanisms that produce the same final state is the most sensitive way to attempt to exclude a theory.

  3. The Newtonian Limit of Geometrostatics

    CERN Document Server

    Cederbaum, Carla

    2012-01-01

    This thesis discusses the Newtonian limit of General Relativity for static isolated systems with compactly supported matter. We call these systems "geometrostatic" to underline their geometric nature. We introduce new quasi-local notions of mass and center of mass that can be read off locally in the vicinity of the matter/black holes. We prove that these notions asymptotically coincide with ADM-mass and the Huisken-Yau CMC-center of mass. Moreover, we prove that they converge to Newtonian mass and center of mass in the Newtonian limit. The Newtonian limit is discussed in the language of Ehlers' frame theory. Furthermore, we prove several uniqueness claims in geometrostatics as well as other geometric and physical properties of these systems. We analyze equipotential sets, provide a pseudo-Newtonian reformulation of geometrostatics, and prove uniqueness of static photon spheres.

  4. Environmental Performance

    DEFF Research Database (Denmark)

    Svabo, Connie; Lindelof, Anja Mølle

    from the perspective of time and liveness as experienced in art on environmental performance discussing how environmental performances frame the temporality of the world. The paper engages with contemporary examples of environmental performances from various disciplines (sound, video, television...

  5. Performance Appraisal.

    Science.gov (United States)

    Holloway, Mary Louise

    1988-01-01

    Reviews general facets of performance appraisal pointing out the similarities and differences in methods and instruments used to assess the performance of administrative, academic, and nonacademic personnel. Relates the concepts of merit pay and tenure to performance appraisal. (DMM)

  6. 40 CFR 60.2145 - How do I demonstrate continuous compliance with the emission limitations and the operating limits?

    Science.gov (United States)

    2010-07-01

    ... NEW STATIONARY SOURCES Standards of Performance for Commercial and Industrial Solid Waste Incineration... tests. (c) You must only burn the same types of waste used to establish operating limits during the...

  7. Reconnectable Network with Limited Resources

    Institute of Scientific and Technical Information of China (English)

    史维更

    1991-01-01

    The reachability of a strongly connected network may be destroyed after link damage.Since many networks are directed or equivalent directed,connected by directed links with the potential for reversal.Therefore the reachability can be restored by reversing the direction of links.[1] has studied this matter under unlimited resources (transmitter and receiver) condition.In this paper the reconnectability of a network with limited number of receivers and transmitters is discussed.Also a linear time algorithm is given to find a reconnected reversal for limited receivers and transmitters.

  8. Paradox of simple limiter control.

    Science.gov (United States)

    Hilker, Frank M; Westerhoff, Frank H

    2006-05-01

    Chaos control by simple limiters is an easy-to-implement and effective method of stabilizing irregular fluctuations. Here we show that applying limiter control to a state variable can significantly shift its mean value. In many situations, this is a countereffective as well as unexpected result, when the aim of control is also to restrict the dynamics. We discuss this effect on the basis of a model of population dynamics and conclude that it can have severe implications for the management of pest species and epidemic spread.

  9. Designs of LiMIT as a Limiter in the EAST Tokamak

    Science.gov (United States)

    Szott, Matthew; Christenson, Michael; Kalathiparambil, Kishor; Ruzic, David

    2016-10-01

    Liquid metal plasma facing components (PFCs) provide a constantly refreshing, self-healing surface that can reduce erosion and thermal stress damage to prolong device lifetime, and additionally decrease edge recycling, reduce impurities, and enhance plasma performance. The Liquid Metal Infused Trench (LiMIT) system, developed at UIUC, has demonstrated thermoelectric magnetohydrodynamic (TEMHD) driven flow of liquid lithium through series of solid trenches. This TEMHD effect drives liquid lithium in fusion systems using the plasma heat flux and the toroidal magnetic field, and the surface tension of the liquid lithium maintains a fresh surface on top of the solid trenches. LiMIT has been successfully tested at UIUC as well as HT-7 and Magnum PSI at heat fluxes up to 3 MW/m2. The next step is demonstrating system viability in full-scale fusion-relevant conditions. In collaboration with a team in Hefei, design and testing has begun for a large scale LiMIT system that will act as a limiter in EAST. The designs improve upon previous versions of LiMIT tested at Illinois and incorporate lessons learned from earlier tests of liquid metal PFCs at EAST. Existing infrastructure is used to load and supply lithium to the system, and the LiMIT trenches will help maintain a smooth, fresh surface as well as aid in propelling the lithium out of direct plasma flux to improve heat transfer. Supported by DOE/ALPS DE-FG02-99ER54515.

  10. MHD stability limits in the TCV Tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Reimerdes, H. [Ecole Polytechnique Federale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), CH-1015 Lausanne (Switzerland)

    2001-07-01

    Magnetohydrodynamic (MHD) instabilities can limit the performance and degrade the confinement of tokamak plasmas. The Tokamak a Configuration Variable (TCV), unique for its capability to produce a variety of poloidal plasma shapes, has been used to analyse various instabilities and compare their behaviour with theoretical predictions. These instabilities are perturbations of the magnetic field, which usually extend to the plasma edge where they can be detected with magnetic pick-up coils as magnetic fluctuations. A spatially dense set of magnetic probes, installed inside the TCV vacuum vessel, allows for a fast observation of these fluctuations. The structure and temporal evolution of coherent modes is extracted using several numerical methods. In addition to the setup of the magnetic diagnostic and the implementation of analysis methods, the subject matter of this thesis focuses on four instabilities, which impose local and global stability limits. All of these instabilities are relevant for the operation of a fusion reactor and a profound understanding of their behaviour is required in order to optimise the performance of such a reactor. Sawteeth, which are central relaxation oscillations common to most standard tokamak scenarios, have a significant effect on central plasma parameters. In TCV, systematic scans of the plasma shape have revealed a strong dependence of their behaviour on elongation {kappa} and triangularity {delta}, with high {kappa}, and low {delta} leading to shorter sawteeth with smaller crashes. This shape dependence is increased by applying central electron cyclotron heating. The response to additional heating power is determined by the role of ideal or resistive MHD in triggering the sawtooth crash. For plasma shapes where additional heating and consequently, a faster increase of the central pressure shortens the sawteeth, the low experimental limit of the pressure gradient within the q = 1 surface is consistent with ideal MHD predictions. The

  11. Cost allocation with limited information

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Tind, Jørgen

    all activities have been performed, for example by finishing all outputs. Here the allocation is made progressively with suggestions for activities. I other words cost allocation is performed in parallel for example with a production planning process. This development does not require detailed...

  12. Concepts and limits of cosmetic medicine

    Directory of Open Access Journals (Sweden)

    Francisco Cabello

    2012-07-01

    Full Text Available Cosmetic medicine is becoming increasingly important in the doctor's daily practice, ranging from plastic surgery to areas such as neurology. Therefore, it is important to attempt to understand its concept and limits. If we define cosmetic medicine as "a set of actions performed by a physician with the purpose of improving patient appearance or some other aspect which, although not outside the normal, is expected to be enhanced by request", we should analyze whether these actions fall within the scope of what we currently consider medical practice. We must also consider if such actions are futile or not, and if they are aligned with what we know as modern medicine.

  13. Embracing the quantum limit in silicon computing.

    Science.gov (United States)

    Morton, John J L; McCamey, Dane R; Eriksson, Mark A; Lyon, Stephen A

    2011-11-16

    Quantum computers hold the promise of massive performance enhancements across a range of applications, from cryptography and databases to revolutionary scientific simulation tools. Such computers would make use of the same quantum mechanical phenomena that pose limitations on the continued shrinking of conventional information processing devices. Many of the key requirements for quantum computing differ markedly from those of conventional computers. However, silicon, which plays a central part in conventional information processing, has many properties that make it a superb platform around which to build a quantum computer.

  14. Immunizing complex networks with limited budget

    Science.gov (United States)

    Mirzasoleiman, Baharan; Babaei, Mahmoudreza; Jalili, Mahdi

    2012-05-01

    In this letter we studied the epidemic spreading on scale-free networks assuming a limited budget for immunization. We proposed a general model in which the immunity of an individual against the disease depends on its immunized friends in the network. Furthermore, we considered the possibility that each individual might be eager to pay a price to buy the vaccine and become immune against the disease. Under these assumptions we proposed an algorithm for improving the performance of all previous immunization algorithms. We also introduced a heuristic extension of the algorithm, which works well in scale-free networks.

  15. 77 FR 76841 - Lending Limits

    Science.gov (United States)

    2012-12-31

    ... surplus if the loan is fully secured. Section 5(u)(1) of the Home Owners' Loan Act (HOLA), 12 U.S.C. 1464...) of HOLA, 12 U.S.C. 1464(u)(2), includes exceptions to the lending limits for certain loans made by savings associations. These HOLA provisions apply to both Federal and state-chartered savings...

  16. Corporate Architecture and Limited Liability

    NARCIS (Netherlands)

    Couwenberg, Oscar

    2007-01-01

    Abstract This paper studies the effect of limited liability on corporate architecture. Corporate architecture refers to the use of governance instruments within the firm to control the behavior of employees. Four general instruments are defined that form the basis of the firm as a governance arrange

  17. Historical Drawbacks of Limited Liability

    Directory of Open Access Journals (Sweden)

    Denis Boyle

    2016-07-01

    Full Text Available Limited liability is a human invention which has facilitated enormous economic growth around the world, particularly since the time of its general application in advanced countries during the nineteenth century. The individual legal identity of companies, coupled with the limited liability of their owners, has provided protection for investors from the risks associated with their investments. It has thus contributed to increase the sources of capital available to finance projects which might otherwise have been considered unviable. However, the legal protection offered to investors has negative consequences for other participants in economies. Speculation in stock markets often damages society. It is very important to study the drawbacks of limited liability and to suggest modifications to achieve a more stable, less volatile, economic growth in the world. Although this article goes to some lengths to recognise the work of authors who emphasise the positive historical economic contribution of limited lability, its main objective is to provoke a reflection around texts which point out the drawbacks and propose solutions.

  18. Certifying Equality With Limited Interaction

    DEFF Research Database (Denmark)

    Brody, Joshua Eric; Chakrabarti, Amit; McGregor, Andrew

    2012-01-01

    by focusing on two subtle aspects. The first is to consider the {\\em expected} communication cost (at a worst-case input) for a protocol that uses limited interaction---i.e., a bounded number of rounds of communication---and whose error probability is zero or close to it. The second is to consider the {\\em...

  19. Limits to Scale and Scope

    DEFF Research Database (Denmark)

    Pedersen, Kurt; Sørensen, Peter

    2007-01-01

    slaughterhouse merger in 1890/91 between the established private slaughterhouses and the rising co-operative ones. The article deals with the question of the relevance of Chandler's concepts to the negotiation process and with that of the limits to the explanatory power of the framework. In order to answer...

  20. Explosion limits for combustible gases

    Institute of Scientific and Technical Information of China (English)

    TONG Min-ming; WU Guo-qing; HAO Ji-fei; DAI Xin-lian

    2009-01-01

    Combustible gases in coal mines are composed of methane, hydrogen, some multi-carbon alkane gases and other gases. Based on a numerical calculation, the explosion limits of combustible gases were studied, showing that these limits are related to the concentrations of different components in the mixture. With an increase of C4H10 and C6H14, the Lower ExplosionLimit (LEL) and Upper Explosion-Limit (UEL) of a combustible gas mixture will decrease clearly. For every 0.1% increase in C4H10 and C6H14, the LEL decreases by about 0.19% and the UEL by about 0.3%. The results also prove that, by increasing the amount of H2, the UEL of a combustible gas mixture will increase considerably. If the level of H2 increases by 0.1%, the UEL will increase by about 0.3%. However, H2 has only a small effect on the LEL of the combustible gas mixture. Our study provides a theoretical foundation for judging the explosion risk of an explosive gas mixture in mines.

  1. Landscape genetics and limiting factors

    Science.gov (United States)

    Samuel A. Cushman; Andrew J. Shirk; Erin L. Landguth

    2013-01-01

    Population connectivity is mediated by the movement of organisms or propagules through landscapes. However, little is known about how variation in the pattern of landscape mosaics affects the detectability of landscape genetic relationships. The goal of this paper is to explore the impacts of limiting factors on landscape genetic processes using simulation...

  2. Environmental risk limits for zinc

    NARCIS (Netherlands)

    Bodar CWM; SEC

    2007-01-01

    Environmental Riks Limits (ERLs) were derived for zinc. ERLs serve as advisory values to set environmental quality standards in the Netherlands. The ERLs for zinc closely follow the outcomes of earlier discussions on zinc within the Water Framework Directive and EC Regulation 793/93. The ERLs refer

  3. Environmental risk limits for zinc

    NARCIS (Netherlands)

    Bodar CWM; SEC

    2007-01-01

    Environmental Riks Limits (ERLs) were derived for zinc. ERLs serve as advisory values to set environmental quality standards in the Netherlands. The ERLs for zinc closely follow the outcomes of earlier discussions on zinc within the Water Framework Directive and EC Regulation 793/93. The ERLs ref

  4. The Limits of Collaborative Evaluation.

    Science.gov (United States)

    Lewkowicz, Jo A.; Nunan, David

    1999-01-01

    Describes the development of a collaborative evaluation model and its application to a curricular innovation project within a secondary school system in Hong Kong. Focuses on the limits of collaboration in long-term evaluation projects with multiple stakeholders. (Author/VWL)

  5. The Limits of Collaborative Evaluation.

    Science.gov (United States)

    Lewkowicz, Jo A.; Nunan, David

    1999-01-01

    Describes the development of a collaborative evaluation model and its application to a curricular innovation project within a secondary school system in Hong Kong. Focuses on the limits of collaboration in long-term evaluation projects with multiple stakeholders. (Author/VWL)

  6. Active inrush-current limiter

    Science.gov (United States)

    Kichak, R. A.

    1977-01-01

    By stretching turn-on time from approximately 1 to 200 ms, effects of inrush current (and of associated large current spikes) and current rate of rise (dl/dt) are made potentially less severe. Limiter arrangement consists of time-variable impedance connected in series between input dc power source return and power circuit of converter.

  7. Setting time limits on tests

    NARCIS (Netherlands)

    Linden, van der Wim J.

    2011-01-01

    It is shown how the time limit on a test can be set to control the probability of a test taker running out of time before completing it. The probability is derived from the item parameters in the lognormal model for response times. Examples of curves representing the probability of running out of ti

  8. LIMITS OF THE EARTH BIOSPHERE

    Directory of Open Access Journals (Sweden)

    Karel KUDRNA

    2011-01-01

    Full Text Available Evaluation of the state of CO2 accumulation in the atmosphere demands knowledge on possibilities of the biosphere – its photosynthetizing apparatus, conditions and limits of absorption. A decisive precondition is to determine relation of CO2 accumulation by photosynthesis in dependence on the water balance, especially on its control quantity – transpiration, which is stabilized by supporting of underground waters.

  9. Limits of time in cosmology

    CERN Document Server

    Rugh, Svend E

    2016-01-01

    We provide a discussion of some main ideas in our project about the physical foundation of the time concept in cosmology. It is standard to point to the Planck scale (located at $\\sim 10^{-43}$ seconds after a fictitious "Big Bang" point) as a limit for how far back we may extrapolate the standard cosmological model. In our work we have suggested that there are several other (physically motivated) interesting limits -- located at least thirty orders of magnitude before the Planck time -- where the physical basis of the cosmological model and its time concept is progressively weakened. Some of these limits are connected to phase transitions in the early universe which gradually undermine the notion of 'standard clocks' widely employed in cosmology. Such considerations lead to a 'scale problem' for time which becomes particularly acute above the electroweak phase transition (before $\\sim 10^{-11}$ seconds). Other limits are due to problems of building up a cosmological reference frame, or even contemplating a s...

  10. Time-limited optimal dynamics beyond the Quantum Speed Limit

    DEFF Research Database (Denmark)

    Gajdacz, Miroslav; Das, Kunal K.; Arlt, Jan

    2015-01-01

    The quantum speed limit sets the minimum time required to transfer a quantum system completely into a given target state. At shorter times the higher operation speed has to be paid with a loss of fidelity. Here we quantify the trade-off between the fidelity and the duration in a system driven...... by a time-varying control. The problem is addressed in the framework of Hilbert space geometry offering an intuitive interpretation of optimal control algorithms. This approach leads to a necessary criterion for control optimality applicable as a measure of algorithm convergence. The time fidelity trade......-off expressed in terms of the direct Hilbert velocity provides a robust prediction of the quantum speed limit and allows to adapt the control optimization such that it yields a predefined fidelity. The results are verified numerically in a multilevel system with a constrained Hamiltonian, and a classification...

  11. Diffusion-Limited Aggregation with Polygon Particles

    Institute of Scientific and Technical Information of China (English)

    邓礼; 王延颋; 欧阳钟灿

    2012-01-01

    Diffusion-limited aggregation (DLA) assumes that particles perform pure random walk at a finite tem- perature and aggregate when they come close enough and stick together. Although it is well known that DLA in two dimensions results in a ramified fractal structure, how the particle shape influences the formed morphology is still un- clear. In this work, we perform the off-lattice two-dimensional DLA simulations with different particle shapes of triangle, quadrangle, pentagon, hexagon, and octagon, respectively, and compare with the results for circular particles. Our results indicate that different particle shapes only change the local structure, but have no effects on the global structure of the formed fractal duster. The local compactness decreases as the number of polygon edges increases.

  12. 40 CFR 161.175 - Certified limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Certified limits. 161.175 Section 161... Certified limits. The applicant must propose certified limits for the ingredients in the product. Certified limits become legally binding limits upon approval of the application. Certified limits will apply to...

  13. BENEFITS AND LIMITATIONS TO PREHYDRATION

    Institute of Scientific and Technical Information of China (English)

    David R. Lamb; Adel Helmy Shehata

    1999-01-01

    @@ Key Points ■ Athletes and others who begin exercise with a less than normal volume of body water are likely to experience adverse effects on cardiovascular function, temperature reuglation, and exercise performance.

  14. Limitation and life in space

    Science.gov (United States)

    Israel, Marvin; Smith, T. Scott

    1986-08-01

    ``The Earth is the very quintescence of the human condition...,'' says Hannah Arendt. Georg Simmel writes: ``The stranger is by nature no `owner of soil'—soil not only in the physical, but also in the figurative sense of a life-substance which is fixed, if not in a point in space, at least in an ideal point of social environment.'' How will no longer being Earthbound affect persons' experience of themselves and of others? Space colonization offers an opportunity for new self-definition by the alteration of existing limits. Thus ``limitation'' is a useful concept for exploring the physical, social and psychological significance of the colonization of space. Will people seek the security of routine, of convention, of hierarchy as in the military model governing our present-day astronauts? or will they seek to maximize the freedom inherent in extraordinary living conditions—as bohemians, deviants, travelers?

  15. Surfactants at the Design Limit.

    Science.gov (United States)

    Czajka, Adam; Hazell, Gavin; Eastoe, Julian

    2015-08-04

    This article analyzes how the individual structural elements of surfactant molecules affect surface properties, in particular, the point of reference defined by the limiting surface tension at the aqueous cmc, γcmc. Particular emphasis is given to how the chemical nature and structure of the hydrophobic tails influence γcmc. By comparing the three different classes of surfactants, fluorocarbon, silicone, and hydrocarbon, a generalized surface packing index is introduced which is independent of the chemical nature of the surfactants. This parameter ϕcmc represents the volume fraction of surfactant chain fragments in a surface film at the aqueous cmc. It is shown that ϕcmc is a useful index for understanding the limiting surface tension of surfactants and can be useful for designing new superefficient surfactants.

  16. Nuclear Structure at the Limits

    Energy Technology Data Exchange (ETDEWEB)

    Nazarewicz, W.

    1998-01-12

    One of the frontiers of today�s nuclear science is the �journey to the limits� of atomic charge and nuclear mass, of neutron-to-proton ratio, and of angular momentum. The tour to the limits is not only a quest for new, exciting phenomena, but the new data are expected, as well, to bring qualitatively new information about the fundamental properties of the nucleonic many-body system, the nature of the nuclear interaction, and nucleonic correlations at various energy-distance scales. In this series of lectures, current developments in nuclear structure at the limits are discussed from a theoretical perspective, mainly concentrating on medium-mass and heavy nuclei.

  17. Penrose Limits and Spacetime Singularities

    CERN Document Server

    Blau, Matthias; O'Loughlin, M; Papadopoulos, G; Blau, Matthias; Borunda, Monica; Loughlin, Martin O'; Papadopoulos, George

    2003-01-01

    We give a covariant characterisation of the Penrose plane wave limit: the plane wave profile matrix $A(u)$ is the restriction of the null geodesic deviation matrix (curvature tensor) of the original spacetime metric to the null geodesic, evaluated in a comoving frame. We also consider the Penrose limits of spacetime singularities and show that for a large class of black hole, cosmological and null singularities (of Szekeres-Iyers ``power-law type''), including those of the FRW and Schwarzschild metrics, the result is a singular homogeneous plane wave with profile $A(u)\\sim u^{-2}$, the scale invariance of the latter reflecting the power-law behaviour of the singularities.

  18. Assessing Possibilities & Limits for Solar Cells

    CERN Document Server

    Nayak, Pabitra K; Cahen, David

    2011-01-01

    What are the solar cell efficiencies that we can strive towards? We show here that several simple criteria, based on cell and module performance data, serve to evaluate and compare all types of today's solar cells. Analyzing these data allows to gauge in how far significant progress can be expected for the various cell types and, most importantly from both the science and technology points of view, if basic bounds, beyond those known today, may exist, that can limit such progress. This is important, because half a century after Shockley and Queisser (SQ) presented limits, based on detailed balance calculations for single absorber solar cells, those are still held to be the only ones, we need to consider; most efforts to go beyond SQ are directed towards attempts to circumvent them, primarily via smart optics, or optoelectronics. After formulating the criteria and analyzing known loss mechanisms, use of such criteria suggests - additional limits for newer types of cells, Organic and Dye-Sensitized ones, and th...

  19. Limit on the electric charge of antihydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Capra, A., E-mail: acapra@triumf.ca; Amole, C. [York University, Department of Physics and Astronomy (Canada); Ashkezari, M. D. [Simon Fraser University, Department of Physics (Canada); Baquero-Ruiz, M. [University of California at Berkeley, Department of Physics (United States); Bertsche, W. [University of Manchester, School of Physics and Astronomy (United Kingdom); Butler, E. [Imperial College, Centre for Cold Matter (United Kingdom); Cesar, C. L. [Universidade Federal do Rio de Janeiro, Instituto de Física (Brazil); Charlton, M.; Eriksson, S. [Swansea University, Department of Physics, College of Science (United Kingdom); Fajans, J. [University of California at Berkeley, Department of Physics (United States); Friesen, T. [University of Calgary, Department of Physics and Astronomy (Canada); Fujiwara, M. C.; Gill, D. R. [TRIUMF (Canada); Gutierrez, A. [University of British Columbia, Department of Physics and Astronomy (Canada); Hangst, J. S. [CERN, Physics Department (Switzerland); Hardy, W. N. [University of British Columbia, Department of Physics and Astronomy (Canada); Hayden, M. E. [Simon Fraser University, Department of Physics (Canada); Isaac, C. A. [Swansea University, Department of Physics, College of Science (United Kingdom); Jonsell, S. [Stockholm University, Department of Physics (Sweden); Kurchaninov, L. [TRIUMF (Canada); and others

    2017-11-15

    The ALPHA collaboration has successfully demonstrated the production and the confinement of cold antihydrogen, H̅. An analysis of trapping data allowed a stringent limit to be placed on the electric charge of the simplest antiatom. Charge neutrality of matter is known to a very high precision, hence a neutrality limit of H̅ provides a test of CPT invariance. The experimental technique is based on the measurement of the deflection of putatively charged H̅ in an electric field. The tendency for trapped H̅ atoms to be displaced by electrostatic fields is measured and compared to the results of a detailed simulation of H̅ dynamics in the trap. An extensive survey of the systematic errors was performed, and this work focuses on those due to the silicon vertex detector, which is the device used to determine the H̅ annihilation position. The limit obtained on the charge of the H̅ atom is Q = (−1.3 ± 1.8 ± 0.4) × 10{sup −8}, representing the first precision measurement with H̅ [1].

  20. Finding Horndeski theories with Einstein gravity limits

    Science.gov (United States)

    McManus, Ryan; Lombriser, Lucas; Peñarrubia, Jorge

    2016-11-01

    The Horndeski action is the most general scalar-tensor theory with at most second-order derivatives in the equations of motion, thus evading Ostrogradsky instabilities and making it of interest when modifying gravity at large scales. To pass local tests of gravity, these modifications predominantly rely on nonlinear screening mechanisms that recover Einstein's Theory of General Relativity in regions of high density. We derive a set of conditions on the four free functions of the Horndeski action that examine whether a specific model embedded in the action possesses an Einstein gravity limit or not. For this purpose, we develop a new and surprisingly simple scaling method that identifies dominant terms in the equations of motion by considering formal limits of the couplings that enter through the new terms in the modified action. This enables us to find regimes where nonlinear terms dominate and Einstein's field equations are recovered to leading order. Together with an efficient approximation of the scalar field profile, one can then further evaluate whether these limits can be attributed to a genuine screening effect. For illustration, we apply the analysis to both a cubic galileon and a chameleon model as well as to Brans-Dicke theory. Finally, we emphasise that the scaling method also provides a natural approach for performing post-Newtonian expansions in screened regimes.