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Sample records for alicyclic mono di

  1. Some transition metal complexes derived from mono- and di-ethynyl perfluorobenzenes

    NARCIS (Netherlands)

    Armitt, D.J.; Bruce, M.I.; Gaudio, M.; Zaitseva, N.N.; Skelton, B.W.; White, A.H.; Le Guennic, B.; Halet, J.-F.; Fox, M.A.; Roberts, R.L.; Hartl, F.; Low, P.J.

    2008-01-01

    Transition metal alkynyl complexes containing perfluoroaryl groups have been prepared directly from trimethylsilyl-protected mono- and di-ethynyl perfluoroarenes by simple desilylation/metallation reaction sequences. Reactions between Me3SiC CC6F5 and RuCl(dppe)Cp'[Cp' = Cp, Cp*] in the presence of

  2. Mono-, di-and tetranuclear rhodium (I) complexes of morpholine and ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 123; Issue 6. Mono-, di- and tetranuclear rhodium(I) complexes of morpholine and -methylpiperazine functionalized cyclodiphosph(III)azanes, cis-[(tBuN-)2(PNC4H8X)2] (X = O, NMe). Maravanji S Balakrishna D Suresh Joel T Mague. Volume 123 Issue 6 ...

  3. Mono-, di- and tetranuclear rhodium(I) complexes of morpholine and ...

    Indian Academy of Sciences (India)

    123, No. 6, November 2011, pp. 861–868. c Indian Academy of Sciences. Mono-, di- and tetranuclear rhodium(I) complexes of morpholine and N-methylpiperazine functionalized cyclodiphosph(III)azanes, cis-[( t. BuN-μ)2(PNC4H8X)2] (X = O, NMe). MARAVANJI S BALAKRISHNAa,∗, D SURESHa and JOEL T MAGUEb.

  4. Mono-, Di-, or Trimorphism in Black Sea Ammonia sp.

    Science.gov (United States)

    Altenbach, Alexander V.; Bassler, Barbara

    2014-05-01

    For the genus Ammonia, the size of proloculi was considered one of the valuable taxonomic landmarks, although it may split in first alternating generations. We analysed 140 living (stained) tests of Ammonia sp. from the outer shelf of the Black Sea, collected from 5 stations on a depth gradient (138 to 206 m water depth). Samples were treated by standard technologies, such as live staining, wet sieving, volume detection, counts, and measures by light microscopy. The size of the proloculi was detected, extended by biometric characterisations of 11 measures, 5 qualitative characters, and 4 numerical ratios. Surprisingly, the multitude of test parameters allows the definition of either one highly variable taxon, or several species, or either di- or trimorphism, exclusively resulting from the definition of 'decisive' or 'neglectable' parameters, or parameter subsets. We followed the general taxonomic definition for the species of the genera, and applied, discussed and rejected published criteria considered as taxonomically important. Surprisingly, in result none of the species described hitherto fully correlates with the morphological roundup observed. It is a new species. This conclusion mainly results from the balance of all morphologies, and not from the selection of an ultimate subset.

  5. Biological significance of lysine mono-, di- and trimethylation on histone and non-histone proteins

    International Nuclear Information System (INIS)

    Perez-Burgos, L.

    2006-01-01

    Histones are the proteins that compact DNA into the repeating unit of chromatin known as the nucleosome. The N-termini of histones are subject to a series of post-translational modifications, one of which is methylation. This modification is termed 'epigenetic' because it extends the information encoded in the genome. Lysines can be mono-, di- or tri-methylated at different positions on histones H1, H3 and H4. In order to study the biological role of histone lysine methylation, antibodies were generated against mono-, di- and trimethylated H3-K9 and H3-27. Indeed, different chromatin domains in the mouse nucleus are enriched in distinct forms of histone lysine methylation, such as pericentric heterochromatin and the inactive X chromosome. Interestingly, heterochromatin in Arabidopsis thaliana is enriched in the mono- and di-, but not the trimethylated form of H3-K9. Furthermore, there exists a hierarchy of epigenetic modifications in which H3-K9 trimethylation is found to be upstream of DNA methylation on mouse major satellites. Histone lysine methylation is also involved in gene regulation upon development. One example is the chicken 61538;-globin locus, a region of facultative chromatin that undergoes a loss of di- and trimethylated H3-K27 in mature red blood cells, concomitant with expression of the 61538;-globin genes. SET-domain proteins are enzymes that methylate histones, but some of them are also able to methylate non-histone substrates. In particular, p53 is methylated by Set9 on lysine 372, G9a and Glp-1 on lysine 373 and by Smyd2 on lysine 370. Smyd2 transcript levels are greatly increased upon irradiation and dimethylated p53-370 specifically binds to 53BP1, a protein involved in recognizing DNA double-stranded breaks upon ionizing radiation. These results argue for a novel role of p53-K370 methylation in the biology of DNA damage. In summary, lysine methylation is a post-translational modification that can occur both on histone and non-histone proteins

  6. Separation of mono- and di-PEGylate of exenatide and resolution of positional isomers of mono-PEGylates by preparative ion exchange chromatography.

    Science.gov (United States)

    Nguyen, Ngoc-Thanh Thi; Lee, Jae Sun; Yun, Soi; Lee, E K

    2016-07-29

    Exenatide is a synthetic version of the 39-mer peptide of Exendin-4, which is an FDA-approved therapeutic against Type II diabetes mellitus. However, exenatide has a very short in-serum half-life and PEGylation have been performed to improve its in-serum stability. PEGylation often yields multivalent binding to non-specific residues, and the desired species should be carefully separated by chromatographies. In this study, we first devised an aqueous-phase, two-step PEGylation process. This consists of thiolation of Lys 12 and 27 residues followed by attachment of PEG-maleimide (10kD) to thiol groups. This process yields various species: mono-PEGylates with positional isomers, di-PEGylate, and other higher MW substances. A prep-grade cationic exchange chromatography (HiTrap SP) at pH 3.0 partially separated mono- and di-PEGylates based on the molar ratio of conjugated PEG and peptide and thus molecular weight of the conjugates. To further investigate the chromatographic separation of positional isomers of mono-PEGylates, we prepared two kinds of exenatide analogs by point mutation; K12C and K27C. Each analog was mono-PEGylated with very high yield (>95%). When a mixture of the two positional isomers of mono-PEGylates was applied to HiTrap SP chromatography, K12C-PEGylate and K27C-PEGylate eluted separately at 0.22M and 0.33M NaCl, respectively. When the proportions of acid and its conjugate base of the amino acid residues adjacent to the PEGylation site at pH 3.0 were analyzed, K27C-PEGylate shows stronger positive charge than K12C-PEGylate, and we propose the residence time difference between the two mono-PEGylates could be due to the charge difference. ELISA result shows that the immuno-binding activity of both analogs and their mono-PEGylates are well maintained. Furthermore, both mono-PEGylates of the analogs show higher than 50-fold improved anti-trypsin stability. We expect that mono-PEGylates of the exenatide analogs are alternatives to the conventional C40

  7. MONO, DI and TRI SSRs data extraction & storage from 1403 virus genomes with next generation retrieval mechanism

    Directory of Open Access Journals (Sweden)

    K.V.S.S.R. Murthy

    2017-08-01

    Full Text Available Now a day׳s SSRs occupy the dominant role in different areas of bio-informatics like new virus identification, DNA finger printing, paternity & maternity identification, disease identification, future disease expectations and possibilities etc., Due to their wide applications in various fields and their significance, SSRs have been the area of interest for many researchers. In the SSRs extraction, retrieval algorithms are used; if retrieval algorithms quality is improved then automatically SSRs extraction system will achieve the most relevant results. For this retrieval purpose in this paper a new retrieval mechanism is proposed which will extracted the MONO, DI and TRI patterns. To extract the MONO, DI and TRI patterns using proposed retrieval mechanism in this paper, DNA sequence of 1403 virus genome data sets are considered and different MONO, DI and TRI patterns are searched in the data genome sequence file. The proposed Next Generation Sequencing (NGS retrieval mechanism extracted the MONO, DI and TRI patterns without missing anything. It is observed that the retrieval mechanism reduces the unnecessary comparisons. Finally the extracted SSRs provide the useful, single view and useful resource to researchers.

  8. MONO, DI and TRI SSRs data extraction & storage from 1403 virus genomes with next generation retrieval mechanism.

    Science.gov (United States)

    Murthy, K V S S R; Satyanarayana, K V V

    2017-08-01

    Now a day׳s SSRs occupy the dominant role in different areas of bio-informatics like new virus identification, DNA finger printing, paternity & maternity identification, disease identification, future disease expectations and possibilities etc., Due to their wide applications in various fields and their significance, SSRs have been the area of interest for many researchers. In the SSRs extraction, retrieval algorithms are used; if retrieval algorithms quality is improved then automatically SSRs extraction system will achieve the most relevant results. For this retrieval purpose in this paper a new retrieval mechanism is proposed which will extracted the MONO, DI and TRI patterns. To extract the MONO, DI and TRI patterns using proposed retrieval mechanism in this paper, DNA sequence of 1403 virus genome data sets are considered and different MONO, DI and TRI patterns are searched in the data genome sequence file. The proposed Next Generation Sequencing (NGS) retrieval mechanism extracted the MONO, DI and TRI patterns without missing anything. It is observed that the retrieval mechanism reduces the unnecessary comparisons. Finally the extracted SSRs provide the useful, single view and useful resource to researchers.

  9. Synthesis of the mono- and di(4-(1,1,3,3-tetramethylbutyl)) phosphoric acids

    International Nuclear Information System (INIS)

    Elias, H.; Zaoui, A.; Attou, M.; Hadj Bachir, D.; Bouzidi, N.; Didi, M.

    1995-09-01

    This work is related to the synthesis of organophosphorus extracting agents used in purification of heavy metals such as uranium. The mono- and di (4-(1,1,3,3- tetramethylbutyl)) phenyl phosphoric acids, respectively MOPPA and DOPPA, are synthesizd by reaction of phosphorus pentoxid with 4(1,1,3,3-tetramethylbuthyl)) phenol. the separation of MOPPA from DOPPA is realised by liquid-liquid extraction. The Characterization, carried out by infrared uv-visible spectrophotometries, ph-metry and mass spectrometry, has confirmed the identity of the synthesized products. This study also showed that the products proportions are comporable to those of the homologous products obtained with 2-ethylbexanol in the same synthesis conditions

  10. Mechanism of manganese (mono and di) telluride thin-film formation and properties

    Science.gov (United States)

    Sharma, Raj Kishore; Singh, Gurmeet; Shul, Yong Gun; Kim, Hansung

    2007-03-01

    Mechanistic studies on the electrocrystallization of manganese telluride (MnTe) thin film are reported using aqueous acidic solution containing MnSO 4 and TeO 2. Tartaric acid was used for the inhibition of hydrated manganese oxide anodic growth at counter electrode. A detailed study on the mechanistic aspect of electrochemical growth of MnTe using cyclic voltametry is carried out. Conditions for electrochemical growth of manganese mono and di telluride thin films have been reported using cyclic voltammetric scans for Mn 2+, Te 4+ and combined Mn 2+ and Te 4+. X-ray diffraction showed the formation of polycrystalline MnTe films with cubic, hexagonal and orthorhombic mixed phases. MnTe film morphology was studied using scanning electron microscope. Susceptibility and electrical characterization supports the anti-ferromagnetic behavior of the as-deposited MnTe thin film.

  11. Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet

    DEFF Research Database (Denmark)

    Pedersen, Natalia; Vegh, Zsuzsanna; Burisch, Johan

    2014-01-01

    .ibs.constant-care.dk). During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention. Thereafter, low fermentable oligo-, di-, mono-saccharides and polyols (FODMAP) diet (LFD) was introduced for the next 6 wk while continuing...... the LFD period, median: 67 (37-120), P diet reduced IBS-SSS to

  12. Mono-, di- and trinuclear dioxo complexes of uranium containing hydrazonato and azomethine ligands

    International Nuclear Information System (INIS)

    Gatto, C.C.; Schulz Lang, E.

    2004-01-01

    Mono-, di or trinuclear dioxouranium complexes with benzoylhydrazonato or azomethine ligands were prepared by reactions of common dioxouranium precursors such as UO 2 (NO 3 ) 2 . 6 H 2 O or [NBu 4 ] 2 [UO 2 Cl 4 ] with vanillin benzoylhydrazone (H 2 L 4 ), salicylaldehyde benzoylhydrazone (H 2 L 5 ), 2-hydroxyacetylbenzene salicylhydrazone (H 3 L 6 ) or N-(2-ethoxycarbonyl-3-oxo-but-1-en(1)yl)-2-aminophenol (H 2 L 7 ). Spectroscopic and X-ray crystallographic studies on the complexes [NBu 4 ] 2 [UO 2 Cl 4 ] . 2 H 2 L 4 , [UO 2 (HL 5 )(H 2 L 5 ) 2 ](NO 3 ), [HNEt 3 ] 2 [{UO 2 (L 6 )} 2 ] and [HNEt 3 ] 2 [{UO 2 (L 7 } 3 O)] confirm that the individual donor atom constellation, the size of the potential chelate rings and the acidity of the OH and NH functionalities of the proligands have a strong influence on the structure of the products. (Abstract Copyright [2004], Wiley Periodicals, Inc.) [de

  13. Biodegradation of mono-, di- and trifluoroacetate by microbial cultures with different origins.

    Science.gov (United States)

    Alexandrino, Diogo A M; Ribeiro, Inês; Pinto, Luís M; Cambra, Rafael; Oliveira, Rui S; Pereira, Filipe; Carvalho, Maria F

    2017-08-26

    This work focused on the biodegradation of three structurally related fluoroacetates (FAs), mono- (MFA), di- (DFA) and trifluoroacetate (TFA), using as microbial inocula samples collected from a site with a long history of industrial contamination and activated sludge obtained from a municipal wastewater treatment plant. Biodegradation experiments were carried out under different modes of substrate supplementation, which included (i) FAs fed as sole carbon sources; (ii) FAs (only for DFA and TFA) fed in co-metabolism with sodium acetate; and (iii) mixtures of MFA with DFA or TFA. Biodegradation of the target compounds was assessed through fluoride ion release. Defluorination was obtained in the cultures fed with MFA, while DFA and TFA were recalcitrant in all tested conditions. When present in mixture, DFA was shown to inhibit biodegradation of MFA, while TFA had no effect. A total of 13 bacterial isolates obtained from MFA degrading cultures were found to degrade 20mgL -1 of this compound, as single strains, when supplemented as a sole carbon source. Sequencing of the 16S rRNA gene indicated that among these degrading bacteria only Delftia acidovorans had been previously reported to be able to degrade MFA. This work shows that, despite their similar chemical structures, biodegradation of the three tested FAs is very distinct and draws attention to the unknown impacts that the accumulation of DFA and TFA may have in the environment as a result of their high recalcitrance. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Spectroscopic properties of neuroleptics: IR and Raman spectra of Risperidone (Risperdal) and of its mono- and di-protonated forms

    Science.gov (United States)

    Alparone, Andrea

    2011-10-01

    Structures and IR and Raman spectra of Risperidone in its neutral, mono- and di-protonated forms were calculated in gas phase by DFT-B3LYP/6-31G* level. Mono-protonation occurs at the nitrogen atom of the piperidine ring, while nitrogen atom of the pyrimidine ring is the preferred site for the second protonation. The lowest-energy structure of the mono-protonated Risperidone is characterized by formation of a strong seven-membered O(pyrimidine ring)⋯ +H-N(piperidine ring) intramolecular hydrogen-bonded cycle. In the high-energy spectral region (3500-2500 cm -1), the bands of the N-H + stretches and the changes in wavenumbers and IR intensities of the C-H stretches near to the piperidine nitrogen atom (Bohlmann effect) are potentially useful to discriminate conformations and protonation states. Di-protonated structures can be identified by the presence of an isolated absorption peak located in the low-energy IR region (660-690 cm -1), attributed to the out-of-plane N-H +(pyrimidine ring) bending deformation. The most intense Raman band of neutral Risperidone placed at ca. 1500 cm -1, assigned to C dbnd C(pyrimidine ring) stretch + C dbnd N(pyrimidine ring) stretch, can be a useful vibrational marker to distinguish the neutral from the protonated forms.

  15. New particle formation from sulfuric acid and amines: Similarities and differences between mono-, di-, and trimethylamines

    Science.gov (United States)

    Olenius, Tinja; Halonen, Roope; Kurtén, Theo; Henschel, Henning; Kupiainen-Määttä, Oona; Ortega, Ismael K.; Vehkamäki, Hanna; Riipinen, Ilona

    2017-04-01

    Amines are organic base species that are emitted to the atmosphere from both anthropogenic and natural sources. Both theoretical and laboratory studies suggest that mono-, di-, and trimethylamines (MMA, DMA, and TMA, respectively) are capable of enhancing the initial steps of sulfuric acid-driven aerosol particle formation much more strongly than ammonia (Kurtén et al., 2008; Jen et al., 2014). Despite the potential importance for atmospheric new particle formation, quantitative estimates on the emissions and thermochemical properties of amines remain relatively uncertain. Because of this and also due to computational reasons, recent large-scale modeling studies have treated sulfuric acid-amine nucleation by introducing a single surrogate amine species, the total emissions of which combine together MMA, DMA and TMA but which resembles DMA or TMA in its various properties (e.g. Bergman et al., 2015). On the other hand, there are likely to be differences in the potentials of the three amines to enhance particle formation, causing uncertainties to the lumping approach. Systematic comparisons are needed to evaluate how to treat these species in atmospheric models and to assess what level of simplification is justifiable. In this work, we study the differences and similarities of MMA, DMA and TMA by modeling nanoparticle formation from sulfuric acid, water, and each of the three amines. We simulate molecular cluster concentrations and formation rates at boundary layer conditions with a dynamic cluster population model using quantum chemistry-based cluster evaporation rates, and study the dependence of particle formation rate on precursor vapor concentrations, temperature and relative humidity. The results suggest that for the three amines, there are differences in the nucleation mechanism and hygroscopicity of molecular clusters. However, for DMA and TMA, formation of nanometer-sized particles and its dependence on ambient conditions is roughly similar: both

  16. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

    Science.gov (United States)

    Lee, Ji-Eun; Wang, Chaochen; Xu, Shiliyang; Cho, Young-Wook; Wang, Lifeng; Feng, Xuesong; Baldridge, Anne; Sartorelli, Vittorio; Zhuang, Lenan; Peng, Weiqun; Ge, Kai

    2013-01-01

    Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for H3K4me1/2 on enhancers remain elusive. Furthermore, how these enzymes function on enhancers to regulate cell-type-specific gene expression is unclear. In this study, we identify MLL4 (KMT2D) as a major mammalian H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C). Using adipogenesis and myogenesis as model systems, we show that MLL4 exhibits cell-type- and differentiation-stage-specific genomic binding and is predominantly localized on enhancers. MLL4 co-localizes with lineage-determining transcription factors (TFs) on active enhancers during differentiation. Deletion of Mll4 markedly decreases H3K4me1/2, H3K27ac, Mediator and Polymerase II levels on enhancers and leads to severe defects in cell-type-specific gene expression and cell differentiation. Together, these findings identify MLL4 as a major mammalian H3K4 mono- and di-methyltransferase essential for enhancer activation during cell differentiation. DOI: http://dx.doi.org/10.7554/eLife.01503.001 PMID:24368734

  17. Effect of Mono and Di-rhamnolipids on Biofilms Pre-formed by Bacillus subtilis BBK006.

    Science.gov (United States)

    De Rienzo, Mayri A Díaz; Martin, Peter J

    2016-08-01

    Different microbial inhibition strategies based on the planktonic bacterial physiology have been known to have limited efficacy on the growth of biofilms communities. This problem can be exacerbated by the emergence of increasingly resistant clinical strains. Biosurfactants have merited renewed interest in both clinical and hygienic sectors due to their potential to disperse microbial biofilms. In this work, we explore the aspects of Bacillus subtilis BBK006 biofilms and examine the contribution of biologically derived surface-active agents (rhamnolipids) to the disruption or inhibition of microbial biofilms produced by Bacillus subtilis BBK006. The ability of mono-rhamnolipids (Rha-C10-C10) produced by Pseudomonas aeruginosa ATCC 9027 and the di-rhamnolipids (Rha-Rha-C14-C14) produced by Burkholderia thailandensis E264, and phosphate-buffered saline to disrupt biofilm of Bacillus subtilis BBK006 was evaluated. The biofilm produced by Bacillus subtilis BBK006 was more sensitive to the di-rhamnolipids (0.4 g/L) produced by Burkholderia thailandensis than the mono-rhamnolipids (0.4 g/L) produced by Pseudomonas aeruginosa ATCC 9027. Rhamnolipids are biologically produced compounds safe for human use. This makes them ideal candidates for use in new generations of bacterial dispersal agents and useful for use as adjuvants for existing microbial suppression or eradication strategies.

  18. Isomeric mono-, di-, and tri-bromobenzo-1H-triazoles as inhibitors of human protein kinase CK2α.

    Directory of Open Access Journals (Sweden)

    Romualda Wąsik

    Full Text Available To further clarify the role of the individual bromine atoms of 4,5,6,7-tetrabromotriazole (TBBt, a relatively selective inhibitor of protein kinase CK2, we have examined the inhibition (IC(50 of human CK2α by the two mono-, the four di-, and the two tri- bromobenzotriazoles relative to that of TBBt. Halogenation of the central vicinal C(5/C(6 atoms proved to be a key factor in enhancing inhibitory activity, in that 5,6-di-Br(2Bt and 4,5,6-Br(3Bt were almost as effective inhibitors as TBBt, notwithstanding their marked differences in pK(a for dissociation of the triazole proton. The decrease in pK(a on halogenation of the peripheral C(4/C(7 atoms virtually nullifies the gain due to hydrophobic interactions, and does not lead to a decrease in IC(50. Molecular modeling of structures of complexes of the ligands with the enzyme, as well as QSAR analysis, pointed to a balance of hydrophobic and electrostatic interactions as a discriminator of inhibitory activity. The role of halogen bonding remains debatable, as originally noted for the crystal structure of TBBt with CK2α (pdb1j91. Finally we direct attention to the promising applicability of our series of well-defined halogenated benzotriazoles to studies on inhibition of kinases other than CK2.

  19. Mono- and Di-Alkylation Processes of DNA Bases by Nitrogen Mustard Mechlorethamine.

    Science.gov (United States)

    Larrañaga, Olatz; de Cózar, Abel; Cossío, Fernando P

    2017-12-06

    The reactivity of nitrogen mustard mechlorethamine (mec) with purine bases towards formation of mono- (G-mec and A-mec) and dialkylated (AA-mec, GG-mec and AG-mec) adducts has been studied using density functional theory (DFT). To gain a complete overview of DNA-alkylation processes, direct chloride substitution and formation through activated aziridinium species were considered as possible reaction paths for adduct formation. Our results confirm that DNA alkylation by mec occurs via aziridine intermediates instead of direct substitution. Consideration of explicit water molecules in conjunction with polarizable continuum model (PCM) was shown as an adequate computational method for a proper representation of the system. Moreover, Runge-Kutta numerical kinetic simulations including the possible bisadducts have been performed. These simulations predicted a product ratio of 83:17 of GG-mec and AG-mec diadducts, respectively. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. From Di-Nucleus to Mono-Nucleus - Neck Evolution in Fusion of Massive Systems -

    OpenAIRE

    Abe, Y.; Shen, Caiwan; Boilley, D.; Giraud, B.G.

    2009-01-01

    6 pages, 3 figures, Proceedings of the Japanese French Symposium - New paradigms in Nuclear Physics, Paris, 29th September - 2nd October, to be published in Int. J. of Modern Physics E; International audience; Dynamics of the neck degree of freedom during fusioning process between heavy ions is studied. Time scales of the three degrees of freedom (the relative distance, the neck and the mass-asymmetry) are studied, showing an early equilibration of the neck. This means that a di-nucleus forme...

  1. Isomeric separation and quantitation of di-(2-ethylhexyl) trimellitates and mono-(2-ethylhexyl) trimellitates in blood by LC-MS/MS.

    Science.gov (United States)

    Höllerer, Christine; Müller, Johannes; Göen, Thomas; Eckert, Elisabeth

    2017-09-01

    A new and fast HPLC-method for the simultaneous determination of tri-(2-ethylhexyl) trimellitate (TOTM or TEHTM), its diesters 2,4-di-(2-ethylhexyl) trimellitate (2,4-DEHTM), 1,4-di-(2-ethylhexyl) trimellitate (1,4-DEHTM), 1,2-di-(2-ethylhexyl) trimellitate (1,2-DEHTM) and monoesters 1-mono-(2-ethylhexyl) trimellitate (1-MEHTM), 2-mono-(2-ethylhexyl) trimellitate (2-MEHTM) and 4-mono-(2-ethylhexyl) trimellitate (4-MEHTM) together with di-(2-ethylhexyl) phthalate (DEHP) and its primary metabolite mono-(2-ethylhexyl) phthalate (MEHP) in blood was developed and validated. The analytes are extracted from blood using liquid-liquid extraction and are chromatographically separated by reversed-phase HPLC using core shell material. Quantitative assessment was performed by ESI-tandem mass spectrometry in negative ionization mode using stable isotope dilution. In less than 30min six postulated primary metabolites of TOTM along with the DEHP metabolite MEHP can be selectively and sensitively quantified. Additionally, the method enables the determination of the parent plasticizers TOTM and DEHP. The detection limits in blood were found to range between 0.7-5.5μg/L for all TOTM analytes. Precision and repeatability of the method were proven by relative standard deviations between 0.9% and 8.7%. TOTM, an alternative plasticizer to DEHP, is already increasingly used for medical devices. Nevertheless, data about the human metabolism of TOTM are still limited. The presented method is the first one enabling the simultaneous determination of the parent plasticizers TOTM and DEHP together with their primary degradation products (DEHTM, MEHTM, MEHP) and can thus be applied manifold including the investigation of the human metabolism of TOTM. Copyright © 2017. Published by Elsevier B.V.

  2. Equilibrium binding studies of mono, di and triisocyanide ligands on Au powder surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Ontko, Alyn [Iowa State Univ., Ames, IA (United States)

    1997-10-08

    The author`s group has previously shown that isocyanides are readily adsorbed from solutions to Au powder and bind to the Au surface in an end-on fashion through the terminal carbon. Later work demonstrated that the equilibrium constants for the reversible adsorption of electronically inequivalent isocyanides could be obtained using the Langmuir isotherm technique. This dissertation describes two projects completed which complement the initial findings of this group. Initially, several alkylisocyanides were synthesized to examine the effect of tail length on Au powder adsorption. It was observed that the length of the alkyl chain affected not only the Au surface binding affinity, but also the rate of surface saturation and saturation coverage values. Direct competition studies were also studied using a 13C-labeled isocyanide. These studies demonstrated the stabilization afforded by substrate-substrate packing forces in SAM`s formed by the longer chain isocyanides. In a second study, di and triisocyanides were synthesized to determine the effect that the length of the connecting link and the number of isocyanide groups (as points of attachment) have on Au adsorption stability. The work in this area describes the binding modes, relative binding affinities and surface coverage values for a series of flexible alkyl and xylyldiisocyanides on Au powder surfaces. This report contains only the introductory material, and general summary. Two chapters have been processed separately. 56 refs.

  3. Dysprosium complexes with mono-/di-carboxylate ligands—From simple dimers to 2D and 3D frameworks

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yingjie, E-mail: yzx@ansto.gov.au [Australian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW 2232 (Australia); Bhadbhade, Mohan [Mark Wainwright Analytical Centre, University of New South Wales, Kensington, NSW 2052 (Australia); Scales, Nicholas; Karatchevtseva, Inna [Australian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW 2232 (Australia); Price, Jason R. [Australian Synchrotron, 800 Blackburn Road, Clayton, VIC 3168 (Australia); Lu, Kim; Lumpkin, Gregory R. [Australian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW 2232 (Australia)

    2014-11-15

    Four dysprosium (Dy) single carboxylates, a formate, a propionate, a butyrate and an oxalate have been synthesized and structurally characterized. The structure of Dy(HCO{sub 2}){sub 3} (1) contains nine-fold coordinated Dy polyhedra in perfect tricapped trigonal prisms. They are linked through trigonal O atoms forming 1D pillars which are further linked together through tricapped O atoms into a 3D pillared metal organic framework. The network structure is stable up to 360 °C. The structure of [Dy{sub 2}(C{sub 2}O{sub 4}){sub 3}(H{sub 2}O){sub 6}]·2.5H{sub 2}O (2) contains nine-fold coordinated Dy polyhedra linking together through μ{sub 2}-bridging oxalate anions into a 2D hexagonal layered structure. Both [Dy{sub 2}(Pr){sub 6}(H{sub 2}O){sub 4}]·(HPr){sub 0.5} (3) [Pr=(C{sub 2}H{sub 5}CO{sub 2}){sup −1}] and [Dy{sub 2}(Bu){sub 6}(H{sub 2}O){sub 4}] (4) [Bu=(C{sub 3}H{sub 7}CO{sub 2}){sup −1}] have similar di-nuclear structures. The Raman vibration modes of the complexes have been investigated. - Graphical abstract: Four dysprosium (Dy) complexes with formate, propionate, butyrate and oxalate ligands have been synthesized and characterized. The Dy formato complex has a 3D pillared metal organic framework and the structure is stable up to 360 °C whilst the complexes with longer alkyl chained mono-carboxylates possess similar di-nuclear structures. The Dy oxalato complex has a 2D hexagonal (honeycomb-type) structure. Their Raman vibration modes have been investigated. - Highlights: • New Dysprosium complexes with formate, propionate, butyrate and oxalate ligands. • Crystal structures range from dimers to two and three dimensional frameworks. • Vibrational modes have been investigated and correlated to the structures. • The complexes are thermal robust and stable to over 300 °C.

  4. Stepwise synthesis, structures, and reactivity of mono-, di-, and trimetallic metal complexes with a 6pi + 6pi quinonoid zwitterion.

    Science.gov (United States)

    Taquet, Jean-Philippe; Siri, Olivier; Braunstein, Pierre; Welter, Richard

    2004-11-01

    The benzoquinonemonoimine N,N'-dineopentyl-2-amino-5-alcoholate-1,4-benzoquinonemonoiminium [C(6)H(2)(NHCH(2)t-Bu)(2)(O)(2)] 6, which is a rare example of an organic zwitterion being more stable than its canonical form, is best described as constituted of two chemically connected but electronically not conjugated 6pi electron subunits. The two successive acidities of 6 allow the preparation of mono-, di-, and trimetallic complexes in which the control of the pi-system delocalization becomes possible. Reaction of 6 with NaOt-Bu results in monodeprotonation of one N-H function, and the isolated sodium salt 9, which is stable under N(2), reacts with chloride-bridged Pd(II) homodimetallic complexes, [AuCl(PPh(3))] or trans-[NiCl(Ph)(PPh(3))(2)], to afford the monometallic complexes 10-15 in which the pi-system is localized. A second in situ deprotonation of the remaining N-H amino function of 10 with NaH followed by reaction with [Pd(8-mq)(mu-Cl)](2) (8-mq = orthometalated 8-methylquinoline) affords the homodimetallic complex 17 in which the pi-system of the quinonoid ligand is delocalized between the two metal centers. Deprotonation of both N-H amino functions of the square-planar complex trans-[Ni(N,O)(2)] 15 with NaH and reaction with [Pd(8-mq)(mu-Cl)](2) affords the heterotrimetallic (Pd, Ni, Pd) complex 18 in which the pi-system of the two quinonoid ligands is delocalized between the three metal centers. The crystal structures of the monometallic complexes 10 and 13 and of the dipalladium complex 17 are reported and consequences of metal coordination discussed. Complex 15 was tested in catalytic ethylene oligomerization with AlEtCl(2) as cocatalyst.

  5. Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro

    International Nuclear Information System (INIS)

    Gupta, Rupesh K.; Singh, Jeffery M.; Leslie, Tracie C.; Meachum, Sharon; Flaws, Jodi A.; Yao, Humphrey H-C

    2010-01-01

    Any insult that affects survival of ovarian antral follicles can cause abnormal estradiol production and fertility problems. Phthalate esters (PEs) are plasticizers used in a wide range of consumer and industrial products. Exposure to these chemicals has been linked to reduced fertility in humans and animal models. Di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) decrease serum estradiol levels and aromatase (Arom) expression, prolong estrous cycles, and cause anovulation in animal and culture models. These observations suggest PEs directly target antral follicles. We therefore tested the hypothesis that DEHP (1-100 μg/ml) and MEHP (0.1-10 μg/ml) directly inhibit antral follicular growth and estradiol production. Antral follicles from adult mice were cultured with DEHP or MEHP, and/or estradiol for 96 h. During culture, follicle size was measured every 24 h as a measurement of follicle growth. After culture, media were collected for measurement of estradiol levels and follicles were subjected to measurement of cylin-D-2 (Ccnd2), cyclin-dependant-kinase-4 (Cdk4), and Arom. We found that DEHP and MEHP inhibited growth of follicles and decreased estradiol production compared to controls at the highest doses. DEHP and MEHP also decreased mRNA expression of Ccnd2, Cdk4, and Arom at the highest dose. Addition of estradiol to the culture medium prevented the follicles from DEHP- and MEHP-induced inhibition of growth, reduction in estradiol levels, and decreased Ccnd2 and Cdk4 expression. Collectively, our results indicate that DEHP and MEHP may directly inhibit antral follicle growth via a mechanism that partially includes reduction in levels of estradiol production and decreased expression of cell cycle regulators.

  6. What's Mono?

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español What's Mono? KidsHealth / For Kids / What's Mono? What's in this ... and illnesses like chickenpox . How Do Kids Get Mono? Most people who get mono are between the ...

  7. A low fermentable oligo-di-mono-saccharides and polyols (FODMAP) diet is a balanced therapy for fibromyalgia with nutritional and symptomatic benefits

    Science.gov (United States)

    Marum, Ana Paula; Moreira, Cátia; Tomas-Carus, Pablo; Saraiva, Fernando; Guerreiro, Catarina Sousa

    2017-06-05

    Fibromyalgia is a chronic rheumatic disease producing widespread pain, associated to a major comorbidity -irritable bowel syndrome. Low FODMAPS diet (low fermentable oligo-di-mono-saccharides and polyols diet) has been effective in controlling irritable bowel syndrome symptoms. Overweight is an aggravating factor for fibromyalgia. We studied effects of low fermentable oligo-di-mono-saccharides and polyols diets on fibromyalgia symptoms and weight status. A longitudinal study was performed on 38 fibromyalgia patients using a four-week, repeated assessment as follow: M1 = first assessments/presentation of individual low fermentable oligo-di-mono-saccharides and polyols diet; M2 = second assessments/reintroduction of FODMAPs; M3 = final assessments/nutritional counselling. The assessment instruments applied were: Fibromyalgia Survey Questionnaire (FSQ); Severity Score System (IBS-SSS); visual analogic scale (VAS). Body mass-index/composition and waist circumference (WC) were also measured. Daily macro-micronutrients and FODMAP intake were quantified at each moment of the study. The studied cohort was 37% overweight, 34% obese (average body mass-index 27.4 ± 4.6; excess fat mass 39.4 ± 7%). Weight, body mass-index and waist circumference decreased significantly (p diet, but no significant effect on body composition was observed. All fibromyalgiasymptoms, including somatic pain, declined significantly post-LFD (p Diet adherence" (85%). "Satisfaction with improvement of symptoms" (76%), showed correlating with "diet adherence" (r = 0.65; p diets as a nutritionally balanced approach, contributing to weight loss and reducing the severity of FM fibromyalgiasymptoms.

  8. Consumption of a low fermentable Oligo-, Di-, Mono-saccharides, and polyols diet and irritable bowel syndrome: A systematic review

    Directory of Open Access Journals (Sweden)

    Helia Pourmand

    2017-01-01

    Full Text Available Consumption of low dietary fermentable carbohydrates, including fermentable oligo-, di-, mono-saccharides, and polyols (FODMAP has been hypothesized to improve symptoms of irritable bowel syndrome (IBS. This study was done to summarize findings from earlier evidence on the effect of a low FODMAP diet (LFD on the symptoms of IBS. We searched in ISI Web of Knowledge, PubMed, Scopus, and Google Scholar using the following keywords: “FODMAP” OR “oligosaccharides” OR “disaccharides” OR “Monosaccharaides” in combination with “irritable bowel syndrome” or “IBS” or “Gastrointestinal Disease.” The reference lists of the relevant papers were also examined to avoid missing any publication. No time and language restrictions were applied. The relevant studies were selected through an independent search by two investigators. Overall, 778 relevant articles were found in our initial search. After reviewing title and abstracts, 763 papers were excluded from this review and 15 studies were included. All published studies were interventional studies in which patients with IBS had been recommended or randomized to receive a LFD. Three studies had quasi-experimental design, 9 were parallel randomized clinical trial and 3 studies were of randomized cross-over trials. These studies were conducted between 2009 and 2016. Nine studies were done in Europe, 2 in US, 3 in Australia, and one in Asia. Sample sizes of these studies were varied from 12 to 182. All studies had been conducted on both sexes, with the majority of participants as women (>70%. The age range was between 11 and 74 years in different studies. One study was performed on children, 9 on adults, and 5 others were in young-to-middle age groups. Duration of intervention was varied from 2 days to 16 months (2 studies with <1 week, and others with more than 2 weeks. Eight studies had suggested a significant effect of LFD on the improvement of all IBS symptoms, and 1 study had

  9. Capillary electrophoresis coupled to mass spectrometry employing hexafluoro-2-propanol for the determination of nucleosides and nucleotide mono-, di- and tri-phosphates in baby foods.

    Science.gov (United States)

    Mateos-Vivas, María; Domínguez-Álvarez, Javier; Rodríguez-Gonzalo, Encarnación; Carabias-Martínez, Rita

    2017-10-15

    The present work describes a method for the simultaneous determination of unmodified nucleosides and nucleotide mono-, di- and tri-phosphates by capillary electrophoresis coupled to mass spectrometry (CE-MS). The use of hexafluoro-2-propanol (HFIP) in the separation medium, and as an additive to the sheath liquid of the electrospray interface (ESI), generated a highly efficient and sensitive method. Instrumental limits of detection in the range of 14-53ngmL -1 for nucleosides and 7-23, 20-49 and 64-124ngmL -1 for nucleotide mono-, di-, and tri-phosphates, respectively, were found. Sample treatment involved diluting an aliquot of baby food with ultra-high quality water and applying centrifugation-assisted ultrafiltration (CUF). The proposed method was validated and used to analyse a variety of baby food samples (16 in total) such as fish, meat, fruits, and baby dairy desserts that may endogenously contain these analytes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Mono-, di-, and trichlorinated biphenyls (PCB 1-PCB 39) in the indoor air of office rooms and their relevance on human blood burden.

    Science.gov (United States)

    Kraft, M; Sievering, S; Grün, L; Rauchfuss, K

    2017-12-29

    Exposure to polychlorinated biphenyls (PCBs) from indoor air can lead to a significant increase in lower chlorinated congeners in human blood. Lower chlorinated congeners with short biological half-lives can exhibit an indirect genotoxic potential via their highly reactive metabolites. However, little is known about their occurrence in indoor air and, therefore, about the effects of possible exposure to these congeners. We analyzed all mono-, di-, and trichlorinated biphenyls in the indoor air of 35 contaminated offices, as well as in the blood of the 35 individuals worked in these offices for a minimum of 2 years. The median concentration of total PCB in the indoor air was 479 ng/m 3 . The most prevalent PCBs in the indoor air samples were the trichlorinated congeners PCB 31, PCB 18, and PCB 28, with median levels of 39, 31, and 26 ng/m 3 , respectively. PCB 8 was the most prevalent dichlorinated congener (median: 9.1 ng/m 3 ). Monochlorinated biphenyls were not detected in relevant concentrations. In the blood samples, the most abundant congener was PCB 28; nearly 90% of all mono-, di-, and trichlorinated congeners were attributed to this congener (median: 12 ng/g blood lipid). © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Bromine Incorporation in Regulated and Emerging DBPs and the Relative Predominance of Mono, Di and Trihalogenated DBPs - SLIDES

    Science.gov (United States)

    Examination of bromine incorporation in emerging DBPs vs that of regulated DBPs Study of predominance of di- vs trihalogenated species in different DBP classes Better understand and characterize exposure to DBPs of health concern

  12. Pseudo-four component synthesis of mono- and di-benzylated-1,2,3-triazoles derived from aniline.

    Science.gov (United States)

    Mendoza-Espinosa, Daniel; Negron-Silva, Guillermo E; Lomas-Romero, Leticia; Gutierrez-Carrillo, Atilano; Santillán, Rosa

    2013-12-20

    The pseudo-four component click synthesis of dibenzylated 1,2,3-triazoles derived from aniline is reported. The cycloaddition of sodium azide to N-(prop-2-ynyl)-benzenamine (I) in the presence of equimolar amounts of p-substituted benzyl derivatives, yields a mixture of mono- and dibenzylated 1,2,3-triazoles. When two equivalents of the benzyl derivative are added to the multicomponent reaction, the selective preparation of the dibenzylated compounds is achieved. The reactivity of the aniline N-H bond in monobenzylated 1,2,3-triazoles was tested by treatment with one equivalent of a p-substituted benzyl chloride at 40 °C, rendering the dibenzylated derivatives quantitatively.

  13. Criss-cross Cycloadditions on Ketazines Derived from Alicyclic Ketones

    Directory of Open Access Journals (Sweden)

    Milan Potacek

    2006-01-01

    Full Text Available The reactivity of alicyclic ketazines in criss-cross cycloadditions was investigated. They react with potassium cyanate and ammonium thiocyanate in the presence of acetic acid to form spirocyclic perhydro[1,2,4]triazolo[1,2-a][1,2,4]triazole-1,5-diones and perhydro[1,2,4]triazolo[1,2-a][1,2,4]triazole-1,5-dithiones, respectively, in relatively high yields.

  14. Biologically relevant mono- and di-nuclear manganese II/III/IV complexes of mononegative pentadentate ligands

    DEFF Research Database (Denmark)

    Baffert, Carole; Collomb, Marie-Nöelle; Deronzier, Alain

    2003-01-01

    ,2-diamine) have been prepared. The crystal structure of the Mn(II)-aqua complex of 1, shows it to be dimeric via (mu-kappaO)-bridging through one carboxylate oxygen atom of each of the two ligands. The non-coordinated carboxylate oxygen atoms are H-bonded to the water ligands on the adjacent Mn ion......Manganese(II) complexes of mononegative pentadentate N4O ligands [Mn2(mgbpen)(2)(H2O)(2)](ClO4)(2) (1), (mgbpen(-) = N-methyl-N'-glycyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine) and [Mn-2(bzgbpen)(2)(H2O)(2)](ClO4)(2) ( 2), (bzgbpen(-)=N-benzyl-N'-glycyl-N,N'-bis(2-pyridylmethyl)ethane-1......-bridged dimanganese(III) and di-mu-oxo-dimanganese(II) complexes, depending on solvent. The [Mn(III)-OR](+), R = H or CH3 complexes are generated in water or methanol, respectively, and are potentially useful spectroscopic models for active Mn-lipoxygenases. In acetonitrile, di-mu-oxo-dimanganese(II) complexes...

  15. Impact of exercise training on endothelial function and body composition in young people: a study of mono- and di-zygotic twins.

    Science.gov (United States)

    Hopkins, N D; Stratton, G; Cable, N T; Tinken, T M; Graves, L E F; Green, D J

    2012-02-01

    Flow mediated dilation (FMD) is a surrogate marker of arterial function which can be improved by exercise training. To date, no study has assessed the magnitude of FMD changes in response to exercise training between groups of mono- (MZ) and di-zygotic (DZ) twins. The purpose of this study was therefore to compare FMD in MZ- and DZ twins before and after identical exercise training interventions. At baseline, FMD was assessed using high resolution Duplex ultrasound in 12 twin pairs (6 MZ pairs 13.5 ± 0.8 years, 6 DZ pairs 13.4 ± 0.8 years). Twins completed 8 weeks of exercise training (65-85% HR(max)), consisting of three 45-min sessions per week. Change (Δ) scores were entered into twin versus twin intraclass correlation analyses by group. Change in %body fat (r = 0.63, P = 0.05) was significantly correlated in the MZ, but not the DZ group (r = 0.31, P = 0.23). Change in FMD was also highly correlated in MZ (r = 0.74, P = 0.02) but not in the DZ group (r = 0.37, P = 0.18). Heritability of ΔFMD was estimated at 0.74. Exercise induced changes in FMD were similar within sets of monozygotic twins but not dizygotic twins. These data suggest that a significant portion of the arterial function response to exercise training may be genetically determined.

  16. Enhanced microemulsion formation in lipid-based drug delivery systems by combining mono-esters of mediumchain fatty acids with di- or tri-esters

    Directory of Open Access Journals (Sweden)

    Darshil P. Patel

    2012-06-01

    Full Text Available To develop strategies for selecting appropriate lipids from mono-, di- and tri-esters of medium-chain fatty acids for the development of lipid-based drug delivery systems, ternary phase diagrams of propylene glycol (PG monocaprylate (Capryol® 90; HLB~7, PG dicaprylocaprate (Labrafac™ PG; HLB~2 and glycerol tricaprylocaprate (Labrafac™ Lipophile WL1349; HLB~2 were determined in combination with a common surfactant, PEG-35 castor oil (Cremophor® EL, HLB~13, and water. Particle size and viscosity in different regions of the phase diagrams were measured, solubility of a model drug, danazol, in different lipid-surfactant mixtures was determined, and dispersion testing by diluting selected preconcentrates with 250 ml 0.01 NHCl was performed. Further, phase diagrams were constructed using binary mixtures of lipids (monoester with diester, or monoester with triester in place of single lipids. The phase diagrams of PG dicaprylocaprate and glycerol tricaprylocaprate were similar, while it was distinctly different for PG monocaprylate. The microemulsion regions in phase diagrams were rather limited for individual lipids, and additionally, the diand tri-esters showed pronounced gel regions in the phase diagrams, which could influence drug release from preconcentrates. The mixing of PG monocaprylate (monoester with PG dicaprylocaprate (diester or glycerol tricaprylocaprate (triester had dramatic effects on the performance of lipids as evidenced by the greatly reduced gel phases, much larger microemulsion regions, faster dispersion of the preconcentrates in an aqueous medium, and smaller particle size of the microemulsions subsequently formed.

  17. Mono-, di- and trimethylated homologues of isoprenoid tetraether lipid cores in archaea and environmental samples: mass spectrometric identification and significance.

    Science.gov (United States)

    Knappy, Chris; Barillà, Daniela; Chong, James; Hodgson, Dominic; Morgan, Hugh; Suleman, Muhammad; Tan, Christine; Yao, Peng; Keely, Brendan

    2015-12-01

    Higher homologues of widely reported C(86) isoprenoid diglycerol tetraether lipid cores, containing 0-6 cyclopentyl rings, have been identified in (hyper)thermophilic archaea, representing up to 21% of total tetraether lipids in the cells. Liquid chromatography-tandem mass spectrometry confirms that the additional carbon atoms in the C(87-88) homologues are located in the etherified chains. Structures identified include dialkyl and monoalkyl ('H-shaped') tetraethers containing C(40-42) or C(81-82) hydrocarbons, respectively, many representing novel compounds. Gas chromatography-mass spectrometric analysis of hydrocarbons released from the lipid cores by ether cleavage suggests that the C(40) chains are biphytanes and the C(41) chains 13-methylbiphytanes. Multiple isomers, having different chain combinations, were recognised among the dialkyl lipids. Methylated tetraethers are produced by Methanothermobacter thermautotrophicus in varying proportions depending on growth conditions, suggesting that methylation may be an adaptive mechanism to regulate cellular function. The detection of methylated lipids in Pyrobaculum sp. AQ1.S2 and Sulfolobus acidocaldarius represents the first reported occurrences in Crenarchaeota. Soils and aquatic sediments from geographically distinct mesotemperate environments that were screened for homologues contained monomethylated tetraethers, with di- and trimethylated structures being detected occasionally. The structural diversity and range of occurrences of the C(87-89) tetraethers highlight their potential as complementary biomarkers for archaea in natural environments. Copyright © 2015 John Wiley & Sons, Ltd.

  18. Chemical activity-based environmental risk analysis of the plasticizer di-ethylhexyl phthalate and its main metabolite mono-ethylhexyl phthalate.

    Science.gov (United States)

    Gobas, Frank A P C; Otton, S Victoria; Tupper-Ring, Laura F; Crawford, Meara A; Clark, Kathryn E; Ikonomou, Michael G

    2017-06-01

    The present study applies a chemical activity-based approach to: 1) evaluate environmental concentrations of di-ethylhexyl phthalate (DEHP; n = 23 651) and its metabolite mono-ethylhexyl phthalate (MEHP; n = 1232) in 16 environmental media from 1174 studies in the United States, Canada, Europe, and Asia, and in vivo toxicity data from 934 studies in 20 species, as well as in vitro biological activity data from the US Environmental Protection Agency's Toxicity Forecaster and other sources; and 2) conduct a comprehensive environmental risk analysis. The results show that the mean chemical activities of DEHP and MEHP in abiotic environmental samples from locations around the globe are 0.001 and 10 -8 , respectively. This indicates that DEHP has reached on average 0.1% of saturation in the abiotic environment. The mean chemical activity of DEHP in biological samples is on average 100-fold lower than that in abiotic samples, likely because of biotransformation of DEHP in biota. Biological responses in both in vivo and in vitro tests occur at chemical activities between 0.01 to 1 for DEHP and between approximately 10 -6 and 10 -2 for MEHP, suggesting a greater potency of MEHP compared with DEHP. Chemical activities of both DEHP and MEHP in biota samples were less than those causing biological responses in the in vitro bioassays, without exception. A small fraction of chemical activities of DEHP in abiotic environmental samples (i.e., 4-8%) and none (0%) for MEHP were within the range of chemical activities associated with observed toxicological responses in the in vivo tests. The present study illustrates the chemical activity approach for conducting risk analyses. Environ Toxicol Chem 2017;36:1483-1492. © 2016 SETAC. © 2016 SETAC.

  19. Comparative pharmacokinetics and tissue distribution study of mono-, and di-caffeoylquinic acids isomers of Ainsliaea fragrans Champ by a fast UHPLC-MS/MS method.

    Science.gov (United States)

    Su, Dan; Huang, Jun; Song, Yonggui; Feng, Yulin

    2014-12-01

    Ainsliaea fragrans Champ, as a well-known herb in Traditional Chinese Medicine, was often used in the treatment of gynecological diseases. Caffeoylquinic acids (CQAs) were the bioactive constituents of this plant medicine which primarily contains mono-CQAs (MCQA) and di-CQAs (DCQA). The biosynthesis showed that MCQAs were the precursor of DCQAs. Recent literatures manifested some particular features of DCQAs, different from MCQAs. Therefore it is apparent that a complete and scientific assessment of DCQAs and MCQAs should include not only the DCQAs' pharmacokinetics and distribution but also its degradation products. So an efficient, sensitive rapid resolution liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous determination of the active ingredients in rat plasma and different tissues had been developed and validated. Mass spectrometric detection was performed by selected reaction monitoring mode (MRM) via an electrospray ionization source operating in negative ionization mode. The method was validated in plasma and tissue samples, which showed good linearity over a wide concentration range (r(2)>0.99), and obtained lower limit of quantification (LLOQ) was 2.34 ng·mL(-1) for the analytes in biological samples. The intra- and inter-day assay variability was less than 15%, and the accuracy was between -8.8% and 5.7%. This study provided the pharmacokinetic profiles and the tissue regional distribution of MCQAs, DCQAs and caffeic acid. The results indicated that the DCQAs isomers were absorbed quickly after oral administration and degradation products MCQAs were mostly found in tissues, not in plasma. Besides, 1,5-DCQA was the prior configuration for the isomerization phenomenon. The small intestine was the main absorption site for DCQAs. Interestingly, the content of the DCQA and MCQA isomers was all high in the ovary and uterus, and some could pass through the barrier between the blood and brain obviously. Copyright © 2014

  20. Determination of nucleoside analog mono-, di-, and tri-phosphates in cellular matrix by solid phase extraction and ultra-sensitive LC-MS/MS detection

    Science.gov (United States)

    Bushman, Lane R.; Kiser, Jennifer J.; Rower, Joseph E.; Klein, Brandon; Zheng, Jia-Hua; Ray, Michelle L.; Anderson, Peter L.

    2011-01-01

    An ultra-sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) assay was developed and validated to facilitate the assessment of clinical pharmacokinetics of nucleotide analogs from lysed intracellular matrix. The method utilized a strong anion exchange isolation of mono-(MP), di-(DP), and tri-phosphates (TP) from intracellular matrix. Each fraction was then dephosphorylated to the parent moiety yielding a molar equivalent to the original nucleotide analog intracellular concentration. The analytical portion of the methodology was optimized in specific nucleoside analog centric modes (i.e. tenofovir (TFV) centric, zidovudine (ZDV) centric), which included desalting/concentration by solid phase extraction and detection by LC-MS/MS. Nucleoside analog MP-, DP-, and TP- determined on the TFV centric mode of analysis include TFV, lamivudine (3TC), and emtricitibine (FTC). The quantifiable linear range for TFV was 2.50 to 2000 fmol/sample, and that for 3TC/FTC was 0.10 to 200 pmol/sample. Nucleoside analog MP-, DP-, and TP- determined on the ZDV centric mode of analysis included 3TC and ZDV. The quantifiable linear range for 3TC was 0.10 to 100 pmol/sample, and 5.00 to 2000 fmol/sample for ZDV. Stable labeled isotopic internal standards facilitated accuracy and precision in alternative cell matrices, which supported the intended use of the method for MP, DP, and TP determinations in various cell types. The method was successfully applied to clinical research samples generating novel intracellular information for TFV, FTC, ZDV, and 3TC nucleotides. This document outlines method development, validation, and application to clinical research. PMID:21715120

  1. Mini Black Holes at the LHC: Discovery Through Di-Jet Suppression, Mono-Jet Emission and a Supersonic Boom in the Quark-Gluon Plasma in ALICE, ATLAS and CMS

    CERN Document Server

    Betz, B; Harbach, U; Humanic, T; Koch, B; Stöcker, H

    2006-01-01

    We examine experimental signatures of TeV-mass black hole formation in heavy ion collisions at the LHC. We find that the black hole production results in a complete disappearance of all very high $p_T$ ({$> 500$} GeV) back-to-back correlated di-jets of total mass {$M > M_f \\sim 1$}TeV. We show that the subsequent Hawking-decay produces multiple hard mono-jets and discuss their detection. We study the possibility of cold black hole remnant (BHR) formation of mass $\\sim M_f$ and the experimental distinguishability of scenarios with BHRs and those with complete black hole decay. Finally we point out that a Heckler-Kapusta-Hawking plasma may form from the emitted mono-jets. In this context we present new simulation data of Mach shocks and of the evolution of initial conditions until the freeze-out.

  2. How Is Mono Spread?

    Science.gov (United States)

    ... Videos for Educators Search English Español How Is Mono Spread? KidsHealth / For Teens / How Is Mono Spread? Print My sister has mononucleosis. I drank ... had it. Does this mean that I have mono now? – Kyle* Mono, or mononucleosis, is spread through ...

  3. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 08, Revision 5 (FGE.08Rev5): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since the publi......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since...... the publication of the last revision of this FGE, the EFSA has been requested to evaluate additional toxicological data submitted for two flavouring substances, one on supporting substance 2,5-dihydroxy-2,5-dimethyl-1,4-dithiane [FL-no: 15.006], which support the evaluation of the candidate substance 2...... approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that 59 substances do not give rise to safety concerns at their levels of dietary intake, estimated...

  4. EFSA ; Scientific Opinion on Flavouring Group Evaluation 91, Revision 1 (FGE.91Rev1): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    of two additional substances compared to previous version. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...

  5. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since...... the publication of the last revision of this FGE, the EFSA has been requested to evaluate 10 additional substances, which have been included in the present revision of FGE.08. For the substances methyl methanethiosulphonate [FL-no: 12.159], 2-methylbutane-2-thiol [FL-no: 12.172], 2-methylpropane-2- thiol [FL.......116, 12.120, 12.164, 12.167, 12.199, 15.007, 15.102 and 15.125 and 15.134], evaluated through the Procedure, no appropriate NOAEL was available and additional data are required. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also been...

  6. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 70 flavouring substances in the Flavouring Group Evaluation 08, Revision 3, using the Procedure in Commission Regulation (EC) No 1565...... substances [FL-no: 12.120, 12.093, 12.094, 12.097, 12.100, 12.112, 12.116, 12.164, 12.167, 12.199, 15.007, 15.102 and 15.125 and 15.134] evaluated through the Procedure, no appropriate NOAEL was available and additional data are required. Besides the safety assessment of these flavouring substances...

  7. African swine fever virus encodes for an E2-ubiquitin conjugating enzyme that is mono- and di-ubiquitinated and required for viral replication cycle.

    Science.gov (United States)

    Freitas, Ferdinando B; Frouco, Gonçalo; Martins, Carlos; Ferreira, Fernando

    2018-02-22

    African swine fever virus is the etiological agent of a contagious and fatal acute haemorrhagic viral disease for which there are no vaccines or therapeutic options. The ASFV encodes for a putative E2 ubiquitin conjugating enzyme (ORF I215L) that shows sequence homology with eukaryotic counterparts. In the present study, we showed that pI215L acts as an E2-ubiquitin like enzyme in a large range of pH values and temperatures, after short incubation times. Further experiments revealed that pI215L is polyubiquitinated instead of multi-mono-ubiquitinated and Cys85 residue plays an essential role in the transthioesterification reaction. In infected cells, I215L gene is transcribed from 2 hours post infection and immunoblot analysis confirmed that pI215L is expressed from 4 hpi. Immunofluorescence studies revealed that pI215L is recruited to viral factories from 8 hpi and a diffuse distribution pattern throughout the nucleus and cytoplasm. siRNA studies suggested that pI215L plays a critical role in the transcription of late viral genes and viral DNA replication. Altogether, our results emphasize the potential use of this enzyme as target for drug and vaccine development against ASF.

  8. Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors

    DEFF Research Database (Denmark)

    Larsen, Anja Probst; Francotte, Pierre; Frydenvang, Karla

    2016-01-01

    of a series of mono-, di-, or trialkyl-substituted 7-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides, comprising in total 16 new modulators. The trisubstituted compounds 7b, 7d, and 7e revealed potent activity (EC2× = 2.7-4.3 μM; concentration of compound responsible for a 2-fold increase...... the cyclopropyl group constitutes the best choice of substituent. 7b was subjected to X-ray structural analysis in complex with the GluA2 ligand-binding domain. We propose an explanation of the unexpected structure-activity relationship of this new series of mono-, di-, and trialkyl-substituted 1......, whereas introduction of a 4-cyclopropyl group does not enhance potency of 2,3,4-alkyl-substituted BTDs. A hydrogen bond donor in the 2-position of the BTD is not necessary for modulator potency....

  9. Langmuir-Blodgett mono- and multilayers of (di)alkoxy-substituted poly(p-phenylenevinylene) precursor polymers. 1. Langmuir monolayers of homo- and copolymers of (di)alkoxy-substituted precursor PPVs

    NARCIS (Netherlands)

    Hagting, J.G.; Vos, R.E.T.P. de; Sinkovics, K.; Vorenkamp, E.J.; Schouten, A.J.

    1999-01-01

    The Langmuir monolayer behavior of (di)alkoxy-substituted precursor poly(p-phenylenevinylenes) (PPVs) with a methoxy-leaving group was studied. The average orientation of the aromatic ring and the ether groups at the air-water interface was elucidated by external F-T-infrared reflection spectroscopy

  10. Synthesis of Mono- and Di-Glucosides of Zearalenone and α-/β-Zearalenol by Recombinant Barley Glucosyltransferase HvUGT14077.

    Science.gov (United States)

    Michlmayr, Herbert; Varga, Elisabeth; Lupi, Francesca; Malachová, Alexandra; Hametner, Christian; Berthiller, Franz; Adam, Gerhard

    2017-02-09

    Zearalenone (ZEN) is an estrogenic mycotoxin occurring in Fusarium -infected cereals. Glucosylation is an important plant defense mechanism and generally reduces the acute toxicity of mycotoxins to humans and animals. Toxicological information about ZEN-glucosides is limited due to the unavailability of larger amounts required for animal studies. Hv UGT14077, a recently-validated ZEN-conjugating barley UDP-glucosyltransferase was expressed in Escherichia coli , affinity purified, and characterized. Hv UGT14077 possesses high affinity ( K m = 3 µM) and catalytic efficiency ( k cat / K m = 190 s -1 ·mM -1 ) with ZEN. It also efficiently glucosylates the phase-I ZEN-metabolites α-zearalenol and β-zearalenol, with k cat / K m of 40 and 74 s -1 ·mM -1 , respectively. Hv UGT14077 catalyzes O -glucosylation at C-14 and C-16 with preference of 14-glucoside synthesis. Furthermore, relatively slow consecutive formation of 14,16-di-glucosides was observed; their structures were tentatively identified by mass spectrometry and for ZEN-14,16-di-glucoside confirmed by nuclear magnetic resonance spectroscopy. Recombinant Hv UGT14077 allowed efficient preparative synthesis of ZEN-glucosides, yielding about 90% ZEN-14-glucoside and 10% ZEN-16-glucoside. The yield of ZEN-16-glucoside could be increased to 85% by co-incubation with a β-glucosidase highly selective for ZEN-14-glucoside. Depletion of the co-substrate UDP-glucose was counteracted by a sucrose synthase based regeneration system. This strategy could also be of interest to increase the yield of minor glucosides synthesized by other glucosyltransferases.

  11. Synthesis of Mono- and Di-Glucosides of Zearalenone and α-/β-Zearalenol by Recombinant Barley Glucosyltransferase HvUGT14077

    Directory of Open Access Journals (Sweden)

    Herbert Michlmayr

    2017-02-01

    Full Text Available Zearalenone (ZEN is an estrogenic mycotoxin occurring in Fusarium-infected cereals. Glucosylation is an important plant defense mechanism and generally reduces the acute toxicity of mycotoxins to humans and animals. Toxicological information about ZEN-glucosides is limited due to the unavailability of larger amounts required for animal studies. HvUGT14077, a recently-validated ZEN-conjugating barley UDP-glucosyltransferase was expressed in Escherichia coli, affinity purified, and characterized. HvUGT14077 possesses high affinity (Km = 3 µM and catalytic efficiency (kcat/Km = 190 s−1·mM−1 with ZEN. It also efficiently glucosylates the phase-I ZEN-metabolites α-zearalenol and β-zearalenol, with kcat/Km of 40 and 74 s−1·mM−1, respectively. HvUGT14077 catalyzes O-glucosylation at C-14 and C-16 with preference of 14-glucoside synthesis. Furthermore, relatively slow consecutive formation of 14,16-di-glucosides was observed; their structures were tentatively identified by mass spectrometry and for ZEN-14,16-di-glucoside confirmed by nuclear magnetic resonance spectroscopy. Recombinant HvUGT14077 allowed efficient preparative synthesis of ZEN-glucosides, yielding about 90% ZEN-14-glucoside and 10% ZEN-16-glucoside. The yield of ZEN-16-glucoside could be increased to 85% by co-incubation with a β-glucosidase highly selective for ZEN-14-glucoside. Depletion of the co-substrate UDP-glucose was counteracted by a sucrose synthase based regeneration system. This strategy could also be of interest to increase the yield of minor glucosides synthesized by other glucosyltransferases.

  12. Spectral studies of lanthanide-nucleic acid component interaction: complexes of adenine, adenosine, adenosine 5'-mono-, adenosine 5'-di- and adenosine 5' tri-phosphates with praseodymium(III)

    International Nuclear Information System (INIS)

    Joseph, George; Anjaiah, K.; Misra, S.N.

    1990-01-01

    The interactions of adenine, adenosine, adenosine 5'-mono-, adenosine 5'-di-and adenosine 5'-tri-phosphates with praseodymium(III) have been studied in different stoichiometries and at varying hydrogen ion concentrations by absorption spectral studies. The sharp bands in the spectra have been individually analysed by Gaussian curve analysis, and various spectral parameters have been computed using partial and multiple regression methods on an HP-1000/45 computer. The changes in and the magnitudes of these parameters have been correlated with the degrees of outer- and inner-sphere coordination around praseodymium(III). Crystalline complexes of the type: Pr(nucleotide) 2 (H 2 O) 2 (where nucleotide = AMP, ADP and ATP) have been characterized on the basis of analytical, IR and 1 H NMR spectral data. These studies indicate that the binding of the nucleotide is through phosphoric oxygen. These complexes in aqueous medium show significant ionization which supports the observed weak 4f-4f bands, lower values of nephelauxetic effect and the parameters derived from coulombic and spin-orbit interactions. (author). 3 t abs., 28 refs

  13. Electro-optical and physic-mechanical properties of colored alicyclic polyimide

    Science.gov (United States)

    Kravtsova, V.; Umerzakova, M.; Korobova, N.; Timoshenkov, S.; Timoshenkov, V.; Orlov, S.; Iskakov, R.; Prikhodko, O.

    2016-09-01

    Main optical, thermal and mechanical properties of new compositions based on alicyclic polyimide and active bright red 6C synthetic dye have been studied. It was shown that the transmission ratio of the new material in the region of 400-900 nm and 2.0 wt.% dye concentration was around 60-70%. Thermal, mechanical and electrical properties of new colored compositions were comparable with the properties of original polyimide.

  14. Palladium-catalysed transannular C-H functionalization of alicyclic amines

    Science.gov (United States)

    Topczewski, Joseph J.; Cabrera, Pablo J.; Saper, Noam I.; Sanford, Melanie S.

    2016-03-01

    Discovering pharmaceutical candidates is a resource-intensive enterprise that frequently requires the parallel synthesis of hundreds or even thousands of molecules. C-H bonds are present in almost all pharmaceutical agents. Consequently, the development of selective, rapid and efficient methods for converting these bonds into new chemical entities has the potential to streamline pharmaceutical development. Saturated nitrogen-containing heterocycles (alicyclic amines) feature prominently in pharmaceuticals, such as treatments for depression (paroxetine, amitifadine), diabetes (gliclazide), leukaemia (alvocidib), schizophrenia (risperidone, belaperidone), malaria (mefloquine) and nicotine addiction (cytisine, varenicline). However, existing methods for the C-H functionalization of saturated nitrogen heterocycles, particularly at sites remote to nitrogen, remain extremely limited. Here we report a transannular approach to selectively manipulate the C-H bonds of alicyclic amines at sites remote to nitrogen. Our reaction uses the boat conformation of the substrates to achieve palladium-catalysed amine-directed conversion of C-H bonds to C-C bonds on various alicyclic amine scaffolds. We demonstrate this approach by synthesizing new derivatives of several bioactive molecules, including varenicline.

  15. Cruces genéticos mono y di-híbridos. Una herramienta para establecer ideas previas y propiciar aprendizajes significativos en los estudiantes de grado octavo de la Institución Educativa Santa Rosa de Lima del municipio de Suarez-Tolima

    OpenAIRE

    Barrero Ramirez, Flor Alba

    2011-01-01

    Este trabajo presenta una propuesta didáctica sobre la enseñanza de los cruces genéticos mono y di-híbridos a partir de las ideas previas de los educandos, ideas que fueron detectadas a través de una encuesta, la cual permite seleccionar, secuenciar y presentar a los estudiantes los contenidos relacionados con división celular, conceptos genéticos y leyes de Mendel. Además de tener en cuenta los saberes previos, busca favorecer el aprendizaje de los alumnos del grado octavo de la Institución ...

  16. The formation of quasi-alicyclic rings in alkyl-aromatic compounds

    Science.gov (United States)

    Straka, Pavel; Buryan, Petr; Bičáková, Olga

    2018-02-01

    The alkyl side chains of n-alkyl phenols, n-alkyl benzenes and n-alkyl naphthalenes are cyclised, as demonstrated by GC measurements, FTIR spectroscopy and molecular mechanics calculations. Cyclisation occurs due to the intramolecular interaction between an aromatic ring (-δ) and a hydrogen of the terminal methyl group (+δ) of an alkyl chain. In fact, conventional molecules are not aliphatic-aromatic, but quasi-alicyclic-aromatic. With the aromatic molecules formed with a quasi-alicyclic ring, the effect of van der Waals attractive forces increases not only intramolecularly but also intermolecularly. This effect is strong in molecules with propyl and higher alkyl substituents. The increase of intermolecular van der Waals attractive forces results in bi-linearity in the GC retention time of the compounds in question, observed in the dependence of the logarithm of the relative retention time on the number of carbons in a molecule in both polar and nonpolar stationary phases with both capillary and packed columns. The role of van der Waals forces has been demonstrated using the potential energies of covalent and noncovalent interactions for 2-n-alkyl phenols, n-alkyl benzenes and 1-n-alkyl- and 2-n-alkyl naphthalenes.

  17. Polymer composites on the aryl alicyclic polyimide base with another polymers

    International Nuclear Information System (INIS)

    Zhubanov, B.; Kudajkulova, S.; Musapirova, Z.

    2003-01-01

    Optimal conditions for synthesis of polymer composites on the base of aryl alicyclic polyimide (PI) with thermo stable polymers - polycarbonate (PC) and polysulfone (PS) - were selected. It was found 2 ways for obtain polymer-polymer composites: 1) mechanical mixing in m-cresol the polymers at different ratio of PI/PC and PI/PS equal to 90/10, 80/20,70/30; 2) reaction mixing of solution of PC or PS in m-cresol with monomers for syntheses of polyimide - tree cyclo decen tetra carbonic acid and oxydianiline. Physico-chemical properties and structure of the composites were studied by methods of UR-, X-ray-spectroscopy, optical microscopy and viscosimeter. X-ray phase spectroscopy possess to determine structure of polymers and their changes, phase transformations and conformation of macromolecules under different kinds of influence. It was shown that new modern materials with nano structure can be synthesised by suggested method

  18. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 74, Revision 3 (FGE.74Rev3): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally, related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or wi thout Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08Rev5 (2012)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... approach. For 10 candidate substances in FGE.74Rev3 [FL-no: 12.009, 12.013, 12.020, 12.023, 12.045, 12.074, 12.155, 12.169, 12.241 and 12.280] evaluated through the Procedure, the Panel concluded that additional toxicity data are required....

  19. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 91, Re vision 2 (FGE.91Rev2): Consid eration of simple aliphatic and aromatic sulphides and thiols evaluated by the JECFA (53rd and 68th meetings, ) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev5 (2012)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...

  20. Experimental and theoretical studies on extraction of actinides and lanthanides by alicyclic H-phosphonates

    Energy Technology Data Exchange (ETDEWEB)

    Annam, Suresh; Sivaramakrishna, Akella; Vijayakrishna, Kari [VIT Univ., Tamil Nadu (India). Dept. of Chemistry; Gopakumar, Gopinadhanpillai; Rao, C.V.S. Brahmmananda; Sivaraman, N. [Indira Gandhi Centre for Atomic Research (IGCAR), Tamil Nadu (India). Chemistry Group

    2017-06-01

    Three different alicyclic substituents H-phosphonates, namely, dicyclopentyl H-phosphonate, dicyclohexyl H-phosphonate and dimenthyl H-phosphonate were synthesized and used for liquid-liquid extraction of actinide elements (U, Am and Th) and lanthanide (Gd) in n-dodecane from nitric acid medium. The physicochemical properties of the extractants, such as density, viscosity, solubility were determined. At lower acidities, these H-phosphonates exhibit higher distribution values and the extraction following cation exchange mechanism through P-OH group of tri-coordinated phosphite form. At higher acidities (2N), the extraction is primarily via solvation mechanism through P=O group of penta-coordinated phosphonate form. Amongst the three H-phosphonates, examined dimenthyl H-phosphonate showed the best results for the actinide extraction. Density functional theory (DFT) calculations were applied to understand the electronic structure of the ligands and the metal complexes. The calculated large complexation energy of UO{sub 2}(NO{sub 3}){sub 2}.@2DMnHP is in agreement with the observed trend in experimental distribution ratio data.

  1. Reaction kinetics and modeling of photoinitiated cationic polymerization of an alicyclic based diglycidyl ether

    International Nuclear Information System (INIS)

    Harikrishna, R.; Ponrathnam, S.; Tambe, S.S.

    2014-01-01

    Highlights: • Photocationic polymerization of alicyclic based diglycidyl ether was carried out. • Kinetic parameters were influenced by gelation and diffusional restrictions. • Applicability of autocatalytic model was established by nonlinear regression. • System showed higher activation energy than cycloaliphatic and aromatic diepoxides. -- Abstract: Photoinitiated cationic polymerization of cycloaliphatic diepoxides had received tremendous attention, while studies with lesser polymerizable diglycidyl ethers are comparatively less reported. The present work deals with the photoinitiated cationic polymerization of cyclohexane dimethanol diglycidyl ether followed by estimation of kinetic parameters. The effects of concentration of photoinitiator and temperature on curing performance were studied using photo differential scanning calorimeter or photo DSC with polychromatic radiation. It was observed that the rate of polymerization as well as ultimate conversion increased with increasing concentration of photoinitiator and temperature. The influences of gelation as well as diffusional restrictions have remarkable effect on cure performance. The kinetic parameters as per autocatalytic kinetic model were studied by Levenberg–Marquardt nonlinear regression method instead of conventional linear method for obtaining more accurate values of apparent rate constant. It was observed that the model fits with data from initial stages to almost towards the end of the reaction. The activation energy was found to be higher than the values reported for more reactive cycloaliphatic diepoxides. The value of pre-exponential factor increased with increase in activation energy showing influence of gelation at early stages of reaction

  2. Effect of Ring Size in ω-Alicyclic Fatty Acids on the Structural and Dynamical Properties Associated with Fluidity in Lipid Bilayers.

    Science.gov (United States)

    Poger, David; Mark, Alan E

    2015-10-27

    Fatty acids containing a terminal cyclic group such as cyclohexyl and cycloheptyl are commonly found in prokaryotic membranes, especially in those of thermo-acidophilic bacteria. These so-called ω-alicyclic fatty acids have been proposed to stabilize the membranes of bacteria by reducing the fluidity in membranes and increasing lipid packing and lipid chain order. In this article, molecular dynamics simulations are used to examine the effect of 3- to 7-membered cycloalkyl saturated and unsaturated (cyclopent-2-enyl and phenyl) rings in ω-alicyclic fatty acyl chains on the structure (lipid packing, lipid chain order, and fraction of gauche defects in the chains) and dynamics (lateral lipid diffusion) of a model lipid bilayer. It was found that ω-alicyclic chains in which the ring was saturated reduced lipid condensation and lowered chain order which would be associated with enhanced fluidity. However, this effect was limited. The lateral diffusion of the lipids diminished as the ring size increased. In particular, ω-cyclohexyl and ω-cycloheptyl acyl tails led to a decrease in lipid diffusion. In contrast, ω-alicyclic acyl chains that contain an unsaturated ring promoted membrane fluidity both in terms of changes in membrane structure and lipid diffusion. This may indicate that saturated and unsaturated terminal rings in ω-alicyclic fatty acids fulfill alternative functions within membranes. Overall, the simulations suggest that ω-alicyclic fatty acids in which the terminal ring is saturated might protect the membrane of thermo-acidophilic bacteria from high-temperature and low-pH conditions through a "dynamical barrier" that would limit lipid diffusion and transmembrane diffusion of undesired ions and molecules.

  3. Mono-X, dijet, and long-lived particle searches at the LHC

    CERN Document Server

    McDonald, Emily; The ATLAS collaboration

    2016-01-01

    This document presents a summary of the most recent Run II searches and results in the mono-X (photon, Z/W/H), mono-/di-jet, and long-lived particle channels for the ATLAS and CMS experiments. Limits on Simplified Models of dark matter and Effective Field Theories in each channel are also presented where relevant as a complement to the SUSY, BSM Higgs, and Invisible Higgs results which are to be covered in a separate presentation.

  4. Separation of polychlorinated dibenzo-p-dioxins/furans, non-ortho/mono/di/tri/tetra-ortho-polychlorinated biphenyls, and polybrominated diphenyl ethers groups of compounds prior to their determination with large volume injection gas chromatography-Quadrupole ion storage tandem mass spectrometry.

    Science.gov (United States)

    Roszko, Marek; Szymczyk, Krystyna; Jędrzejczak, Renata

    2013-10-17

    Polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are important environmental contaminants. Their maximum legally allowable levels in food and environment are in the low pg g(-1) range. Therefore some highly selective and sensitive analytical methods must be used to determine them. Prior to final determination by GC/MS the cleaned-up samples have to be split into some fractions in view of large differences in concentrations of various analytes and existence of numerous chromatographic co-elutions (which in any case cannot be fully avoided). The aim of this study was to: (i) develop a robust, time-saving analytical method to isolate, clean-up and fractionate PCBs, PBDEs and PCDD/Fs prior to their determination with gas chromatography/ion trap mass spectrometry; (ii) assess method performance using laboratory validation data and some certified reference materials; (iii) use the developed method to assess PCB/PBDE/PCDD/F levels in samples of commercially available food. A combination of alumina, florisil, modified silica gel and two carbon columns were used for sample cleanup and fractionation. Separate fractions containing dioxins/furans, PBDE, non-ortho, mono-ortho and di-/tri-/tetra-ortho PCBs were obtained. The method statistical parameters were compatible with 1883/2006 EC Regulation (80-120%, RSD below 15%). The method performance was successfully used to evaluation of some real life food samples. Copyright © 2013 Elsevier B.V. All rights reserved.

  5. Mono pile foundation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lyngesen, S.; Brendstrup, C.

    1997-02-01

    The use of mono piles as foundations for maritime structures has been developed during the last decades. The installation requirements within the offshore sector have resulted in equipment enabling driving of piles up to 3-4 m to large penetration depths. The availability of this equipment has made the use of large mono piles feasible as foundations for structures like wind turbines. The mono pile foundations consists of three parts; the bare pile, a conical transition and a boat landing. All parts are prefitted at the yard in order to minimise the installation work that has to be carried out offshore. The study of a mono pile foundations for a 1.5 MW wind turbine has been conducted for two locations, Horns Rev and Roedsand. Three different water depths: 5, 8 and 11 m have been investigated in the study. The on-site welding between pile and conical transition is performed by an automatic welding machine. Final testing and eventually repair of the weld are conducted at least 16 hours after welding. This is followed by final installation of J-tube, tie-in to subsea cables and installation of the impressed current system for corrosive protection of the mono pile. The total cost for procurement and installation of the mono pile using the welded connection is estimated. The price does not include procurement and installation of access platform and boat landing. These costs are estimated to 250.000 DKK. Depending on water depth the cost of the pile ranges from 2,2 to 2,7 million DKK. Procurement and fabrication of the pile are approx. 75% of the total costs. The remaining 25% are due to installation. The total costs are very sensitive to the unit price of pile steel. During the project it became obvious that ice load has a very large influence on the dimensions of the mono pile. (EG)

  6. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2016. Scientific Opinion on Flavouring Group Evaluation 51, Revision 2 (FGE.51Rev2): Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by the JECFA (59th meeting, ) structurally related to alicyclic ketones secondary alcohols and related esters in FGE.09Rev6 (2015b)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    on metabolism and toxicity. The present consideration concerns a group of 24 alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting in 2002 and 63rd meeting in 2004). This revision is made due to inclusion of four additional substances cleared for genotoxicity concern...

  7. EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 51, Revision 1: Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by the JECFA (59th meeting) structurally related to alicyclic, ketones secondary alcohols and related esters in FGE.09Rev3 (2011)

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 20 alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting) in 2002. This revision is made due to inclusion of seven additional substances...

  8. Biochemical Properties of a New Cold-Active Mono- and Diacylglycerol Lipase from Marine Member Janibacter sp. Strain HTCC2649

    Directory of Open Access Journals (Sweden)

    Dongjuan Yuan

    2014-06-01

    Full Text Available Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1 from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1, Penicillium camembertii lipase U-150 (PCL, and Aspergillus oryzae lipase (AOL. Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity.

  9. Preparation of mono- and diacetyl 4,4′-dimethylbiphenyl and their corresponding carboxylic acids

    DEFF Research Database (Denmark)

    Titinchi, Salam J.J.; Kamounah, Fadhil S.; Abbo, Hanna S.

    2007-01-01

    Shape selective acetylation of 4,4′-dimethylbiphenyl using anhydrous aluminum chloride as catalyst is an effective route for the production of mono- and di-acetyl-4,4′-dimethylbiphenyl. Preparations, characterization and a catalytic study of the Friedel-Crafts acetylation of 4,4′-dimethylbiphenyl......, involving use of the Perrier addition procedure are carried out in a range of solvents and under a variety of experimental conditions. The obtained ketones are isolated and identified by various physico-chemical techniques. Mono acetylation of 4,4′-dimethylbiphenyl afforded a mixture of two isomeric acetyl...... dimethylbiphenyls. In chloroalkane or carbon disulfide solvent, the yields of isomers were in the order: 2 -> 3-; in nitromethane 3-isomer predominated. On the other hand diacetylation of the hydrocarbon gave only the 2,3′-diacetyl isomer. The mono- and di-ketones are converted to the corresponding carboxylic acids...

  10. Festival nimega Mono / Ivar Sakk

    Index Scriptorium Estoniae

    Sakk, Ivar, 1962-

    2015-01-01

    Haapsalu graafilise disaini festival Haapsalu Linnagaleriis: sisaldab ülevaate- ja teemanäitust ning väikest sümpoosioni. Temaatilise aastanäituse motiiv on "MONO". Plakateid on ka välismaa tegijatelt. Kuraator Marko Kekishev

  11. Searches with mono-leptons

    Energy Technology Data Exchange (ETDEWEB)

    Bai, Yang; Tait, Tim M. P.

    2013-06-01

    We explore the implications of the mono-lepton plus missing transverse energy signature at the LHC, and point out its significance on understanding how dark matter interacts with quarks, where the signature arises from dark matter pair production together with a leptonically decaying W boson radiated from the initial state quarks. We derive limits using the existing W' searches at the LHC, and find an interesting interference between the contributions from dark matter couplings to up-type and down-type quarks. Mono-leptons can actually furnish the strongest current bound on dark matter interactions for axial-vector (spin-dependent) interactions and iso-spin violating couplings. Should a signal of dark matter production be observed, this process can also help disentangle the dark matter couplings to up- and down-type quarks.

  12. Scientific Opinion on the safety and efficacy of aliphatic and alicyclic ethers (chemical group 16) when used as flavourings for all animal species

    OpenAIRE

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

    2012-01-01

    Chemical group 16 consists of aliphatic and alicyclic ethers, of which four are currently authorised for use as flavours in food. The FEEDAP Panel was unable to perform an assessment of 1,5,5,9-tetramethyl-13-oxatricyclo[8.3.0.0.(4.9)]tridecane and theaspirane because of issues related to the purity of the compounds. The FEEDAP Panel concludes that: i)1,8-cineole is safe at the high use level proposed by the applicant (5 mg/kg complete feed) for all animal species with a margin of safety of 5...

  13. Synthesis of Enantiopure Alicyclic Ethers and Their Activity on the Chemosensory Organ of the Ectoparasite of Honey Bees, Varroa destructor.

    Science.gov (United States)

    Pinnelli, Govardhana R; Singh, Nitin K; Soroker, Victoria; Plettner, Erika

    2016-11-16

    The preparation of enantiopure conformationally restricted alicyclic ethers and their inhibitory activities on the chemosensory organ of the Varroa destructor, a parasite of honey bees, are reported in this article. We tested the effect of enantiopure ethers of cis-5-(2'-hydroxyethyl)cyclopent-2-en-1-ol on the Varroa chemosensory organ by electrophysiology, for their ability to inhibit the responses to two honey bee-produced odors that are important for the mite to locate its host: nurse bee head space odor and (E)-β-ocimene, a honey bee brood pheromone. Previous work with the racemic compounds showed that they suppress the mite's olfactory response to its bee host, which led to incorrect host choice. Based on a structure-activity relationship, we predicted that the two most active compounds-cis-1-butoxy-5-(2'-methoxyethyl)cyclopent-2-ene, cy{4,1}, and (cis-1-ethoxy-5-(2'ethoxyethyl)cyclopent-2-ene, cy{2,2}-could have opposite active enantiomers. Here we studied the enantiomers of both ethers, whose preparation involved enzymatic resolution of racemic diol cis-5-(2'-hydroxyethyl)cyclopent-2-en-1-ol using Lipase AK with vinyl acetate. The racemic diol was prepared from commercially available 2,5-norbornadiene. We observed that the responses of the chemosensory organ to honey bee head space volatiles were significantly decreased by both enantiomers of cy{4,1} and cy{2,2}, but that responses to (E)-β-ocimene were decreased significantly only by (+)-cy{4,1} (1R,5S) and (-)-cy{2,2} (1S,5R) and not by their respective enantiomers. The importance of this result is that the racemates could be used to inhibit olfactory detection of bee odors by mites, without a loss in activity relative to the more expensive enantiopure compounds.

  14. Simultaneous determination of mono- and disubstituted polyfluoroalkyl phosphates in drinking water by liquid chromatography-electrospray tandem mass spectrometry.

    Science.gov (United States)

    Ding, Huanhuan; Peng, Hui; Yang, Min; Hu, Jianying

    2012-03-02

    A sensitive liquid chromatography-electrospray tandem mass spectrometry method was established for the simultaneous determination of five monosubstituted polyfluoroalkyl phosphates (monoPAPs) and eight disubstituted polyfluoroalkyl phosphates (diPAPs) in drinking water. Complete separation and good retention for 13 polyfluoroalkyls phosphates (PAPs) were achieved with a Waters ACUITY UPLC BEH C8 column using a mixture of methanol/water containing 0.1% NH₄OH as the mobile phases. Extraction of drinking water samples was performed on weak anion exchange (WAX) cartridges, and the recoveries of target compounds were from 65 to 110%. The limits of quantization (LOQs) for 13 analytes were in the range of 0.4-40 ng/L. This method was applied to analyze the PAPs in drinking water samples from three cities in China. Of the 13 PAPs, six PAPs including 6:2 monoPAP (13.0 ng/L), 8:2 monoPAP (3.6 ng/L), 10:1 monoPAP (4.3-70.3 ng/L), 10:2 monoPAP (1.4-5.6 ng/L), 8:2 diPAP (0.10 ng/L), and 10:1 diPAP (0.8-3.8 ng/L) were detected. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Cycling of marine dissolved organic carbon: New insights from radiocarbon distribution within carboxylic-rich alicyclic molecules and acylated heteropolysaccharides

    Science.gov (United States)

    Zigah, P.; Beaupre, S. R.; Repeta, D.; McNichol, A. P.; Xu, L.; Aluwihare, L.

    2016-02-01

    Dissolved organic carbon (DOC) is the largest reservoir of reduced carbon in the ocean with a carbon inventory similar to that of the atmosphere. Natural-abundance radiocarbon (14C) and stable carbon (13C) isotopic measurements have been used to constrain DOC biogeochemistry. However, most of these measurements were performed on bulk-, ultrafiltered-, or hydrophobic DOC and represent the average isotopic composition of all respective DOC constituents. There is, however, good evidence that the constituent molecules span a large range of 14C and 13C values [1, 2, 3], and accordingly cycle on a variety of timescales. In this study, we used a detailed size and chemical fractionation approach to comprehensively examine the isotopic distribution of carboxylic-rich alicyclic molecules (CRAM) and acylated heteropolysaccharides (APS) within marine DOC. Seawater samples from the North Central Pacific ocean (22o 45'N, 158oW) were separated into APS and CRAM by ultrafiltration and solid phase extraction. We used a thermal serial oxidation approach to link the isotopic diversity of DOC to its major structural components. Our data revealed isotopic heterogeneity in the DOC pool, with radiocarbon-enriched APS (1000 14C yr to modern) mixed with relatively radiocarbon-depleted CRAM (ca. 1000 - 2500 14C yr) in surface waters of the North Central Pacific ocean. In the deep ocean, a major component of APS had a radiocarbon value similar to that of ambient dissolved inorganic carbon (DIC) indicating conservative transport, or perhaps, a chemosynthetic origin. In contrast, deep ocean CRAM ( 3000-8000 years) was much older than ambient DIC and the APS fraction (2000 - 3500 years), but also exhibited considerable isotopic diversity in its constituent organic compounds. Our data constrain the minimum age distribution of the majority of DOC, and allows for better modeling of DOC in the marine carbon cycle. Cited work: [1] Beaupre et al. 2007. Limnology and Oceanography: Methods 5: 174

  16. Two new coordination polymers with flexible alicyclic carboxylate and bipyridyl co-ligands bearing trinuclear [Ni3(COO)6] SBUs: Synthesis, crystal structures, and magnetic properties

    Science.gov (United States)

    Zhu, Xian-Dong; Li, Yong; Gao, Jian-Gang; Wang, Fen-Hua; Li, Qing-Hai; Yang, Hong-Xun; Chen, Lei

    2017-02-01

    Two new coordination polymers generally formulated as [Ni3(Hchda)2(chda)2(bpy)2(H2O)2]n (1) and [Ni3(Hchda)2(chda)2(bpp)2(H2O)2]n (2) [H2chda = 1,1'-cyclohexanediacetic acid, bpy = 4,4'-bipyridine and bpp = 1,3-bis(4-pyridyl)propane], have been successfully assembled through mixed-ligands synthetic strategy with flexible alicyclic carboxylate and bipyridyl ligands. There structures feature trinuclear nickel secondary building units connected via the bridging bipyridyl spacers to form two-dimensional (4,4) grid layer. The nature of the different N-donor auxiliary ligands leads to the discrepancy in supramolecular structure of the two compounds. Magnetic studies indicate the ferromagnetic intra-complex magnetic interaction in the molecule for 1 and 2.

  17. 21 CFR 172.834 - Ethoxylated mono- and diglycerides.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Ethoxylated mono- and diglycerides. 172.834 Section... HUMAN CONSUMPTION Multipurpose Additives § 172.834 Ethoxylated mono- and diglycerides. The food additive ethoxylated mono-and diglycerides (polyoxyethylene (20) mono- and diglycerides of fatty acids) (polyglycerate...

  18. 21 CFR 184.1505 - Mono- and diglycerides.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Mono- and diglycerides. 184.1505 Section 184.1505... Listing of Specific Substances Affirmed as GRAS § 184.1505 Mono- and diglycerides. (a) Mono- and diglycerides consist of a mixture of glyceryl mono- and diesters, and minor amounts of triesters, that are...

  19. Componentes voláteis do café torrado. Parte II. Compostos alifáticos, alicíclicos e aromáticos Volatile components in roasted coffee. Part II. Aliphatic, alicyclic and aromatic compounds

    Directory of Open Access Journals (Sweden)

    Ricardo Felipe Alves Moreira

    2000-04-01

    Full Text Available This review is about the aliphatic, alicyclic and aromatic compounds (non-heterocyclic compounds that are present in the volatile fractions of roasted coffees. Herein, the contents, aroma precursors and the sensorial properties of volatile phenols, aldehydes, ketones, alcohols, ethers, hydrocarbons, carboxylic acids, anhydrides, esters, lactones, amines and sulphur compounds are discussed. Special attention is given to the compounds of these groups that are actually important to the final aroma of roasted coffees.

  20. Tubes, Mono Jets, Squeeze Out and CME

    Energy Technology Data Exchange (ETDEWEB)

    Longacre, R. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-10-23

    Glasma Flux Tubes, Mono Jets with squeeze out flow around them plus the Chiral Magnetic Effect(CME) are physical phenomenon that generate two particle correlation with respect to the reaction plane in mid-central 20% to 30% Au-Au collision √sNN = 200.0 GeV measured at RHIC.

  1. 40 CFR 721.3486 - Polyglycerin mono(4-nonylphenyl) ether.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Polyglycerin mono(4-nonylphenyl) ether... Substances § 721.3486 Polyglycerin mono(4-nonylphenyl) ether. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a polyglycerin mono(4...

  2. Improved methods for thermal rearrangement of alicyclic α-hydroxyimines to α-aminoketones: synthesis of ketamine analogues as antisepsis candidates.

    Science.gov (United States)

    Elhawi, Hagit; Eini, Hadar; Douvdevani, Amos; Byk, Gerardo

    2012-06-04

    Ketamine is an analgesic/anesthetic drug, which, in combination with other drugs, has been used as anesthetic for over 40 years. Ketamine induces its analgesic activities by blocking the N-methyl-D-aspartate (NMDA) receptor in the central nervous system (CNS). We have reported that low doses of ketamine administrated to patients before incision significantly reduced post-operative inflammation as reflected by reduced interleukin-6 (IL-6) sera-levels. Our data demonstrated in a rat model of Gram-negative bacterial-sepsis that if we inject a low dose of ketamine following bacterial inoculation we reduce mortality from approximately 75% to 25%. Similar to what we have observed in operated patients, the levels of TNF-α and IL-6 in ketamine-treated rats were significantly lower than in septic animals not treated with ketamine. On the base of these results, we have designed and synthesized series of new analogues of ketamine applying a thermal rearrangement of alicyclic α-hydroxyimines to a-aminoketones in parallel arrays. One of the analogues (compound 6e) displayed high activity in down-regulating the levels of IL-6 and TNF-α in vivo as compared to ketamine.

  3. Improved Methods for Thermal Rearrangement of Alicyclic α-Hydroxyimines to α-Aminoketones: Synthesis of Ketamine Analogues as Antisepsis Candidates

    Directory of Open Access Journals (Sweden)

    Gerardo Byk

    2012-06-01

    Full Text Available Ketamine is an analgesic/anesthetic drug, which, in combination with other drugs, has been used as anesthetic for over 40 years. Ketamine induces its analgesic activities by blocking the N-methyl-D-aspartate (NMDA receptor in the central nervous system (CNS. We have reported that low doses of ketamine administrated to patients before incision significantly reduced post-operative inflammation as reflected by reduced interleukin-6 (IL-6 sera-levels. Our data demonstrated in a rat model of Gram-negative bacterial-sepsis that if we inject a low dose of ketamine following bacterial inoculation we reduce mortality from approximately 75% to 25%. Similar to what we have observed in operated patients, the levels of TNF-α and IL-6 in ketamine-treated rats were significantly lower than in septic animals not treated with ketamine. On the base of these results, we have designed and synthesized series of new analogues of ketamine applying a thermal rearrangement of alicyclic α-hydroxyimines to a-aminoketones in parallel arrays. One of the analogues (compound 6e displayed high activity in down-regulating the levels of IL-6 and TNF-α in vivo as compared to ketamine.

  4. Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase

    Science.gov (United States)

    Watschinger, Katrin; Fuchs, Julian E.; Yarov-Yarovoy, Vladimir; Keller, Markus A.; Golderer, Georg; Hermetter, Albin; Werner-Felmayer, Gabriele; Hulo, Nicolas; Werner, Ernst R.

    2012-01-01

    Alkylglycerol mono-oxygenase (EC 1.14.16.5) forms a third, distinct, class among tetrahydrobiopterin-dependent enzymes in addition to aromatic amino acid hydroxylases and nitric oxide synthases. Its protein sequence contains the fatty acid hydroxylase motif, a signature indicative of a di-iron centre, which contains eight conserved histidine residues. Membrane enzymes containing this motif, including alkylglycerol mono-oxygenase, are especially labile and so far have not been purified to homogeneity in active form. To obtain a first insight into structure–function relationships of this enzyme, we performed site-directed mutagenesis of 26 selected amino acid residues and expressed wild-type and mutant proteins containing a C-terminal Myc tag together with fatty aldehyde dehydrogenase in Chinese-hamster ovary cells. Among all of the acidic residues within the eight-histidine motif, only mutation of Glu137 to alanine led to an 18-fold increase in the Michaelis–Menten constant for tetrahydrobiopterin, suggesting a role in tetrahydrobiopterin interaction. A ninth additional histidine residue essential for activity was also identified. Nine membrane domains were predicted by four programs: ESKW, TMHMM, MEMSAT and Phobius. Prediction of a part of the structure using the Rosetta membrane ab initio method led to a plausible suggestion for a structure of the catalytic site of alkylglycerol mono-oxygenase. PMID:22220568

  5. Plasma etching on large-area mono-, multi- and quasi-mono crystalline silicon

    DEFF Research Database (Denmark)

    Davidsen, Rasmus Schmidt; Schmidt, Michael Stenbæk; Boisen, Anja

    2013-01-01

    for their 16.8% efficient black Si cell using a metal-assisted, chemical etching method on FZ mono-crystalline Si substrates. Yoo et al. [4] use RIE similar to this work on large-area, multi-crystalline Si cells and achieve a 16.1% efficiency despite a relatively high reflectance of 13.3%. Despite several...... using maskless RIE in a O2 and SF6 plasma, and the surface topology was optimized for solar cell applications by varying gas flows, pressure, power and process time. The starting substrates were 156x156 mm p-type, CZ mono-, multi- and quasi-mono crystalline Si wafers, respectively, with a thickness...... of 200 μm. Reflectance measurements of the RIE-textured mono-, multi and quasi-mono Si surfaces were performed using a broadband lightsource (Mikropack DH-2000), an integrating sphere (Mikropack ISP-30-6-R), and a spectrometer (Ocean Optics QE65000, 280-1000 nm). The reference solar spectral irradiance...

  6. Lezioni di fisica teorica

    CERN Document Server

    Caldirola, Piero

    Richiami di meccanica analitica ; richiami di termodinamica ; richiami di elettromagnetismo ; appunti sulla teoria della relatività ; la non validità delle teorie classiche nel mondo microscopico ; la meccanica atomica di Bohr e Sommerfeld ; I fondamenti della meccanica quantistica ; applicazioni nell'equazione di Schroedinger ; meccanica quantistica dei sistemi l'atomo di idrogeno ; particella in un campo elettrico e magnetico ; il calcolo delle perturbazioni nella teoria quantistica ; teoria dell'emissione e dell'assorbimento della luce ; sistemi di particelle identiche ; il legame chimico omopolare nella molecola di idrogeno ; la teoria di Dirac.

  7. Scour properties of mono bucket foundation

    DEFF Research Database (Denmark)

    Stroescu, Ionut Emanuel; Frigaard, Peter Bak

    2016-01-01

    Field experience proved that the Mono Bucket Foundations (MBFs) have good response against scour development. Moreover, the ratio between large diameter (bucket lid) and the small diameter (shaft tower) is the driving parameter for the process of erosion/backfill, like scour protection diameter...... tidal flow. Three structural models have been tested in several tidal cycles with a variation of the current intensity. Three levels of alignment with seabed are taken: one flushing and two more with different levels of misalignment. Field results for installation stage have been collected from...

  8. Di-nucleus dynamics towards fusion of heavy nuclei

    OpenAIRE

    Abe, Y.; Shen, Caiwan; Kosenko, G.; Boilley, D.; Giraud, B.G.

    2008-01-01

    International audience; The Two-Step Model for fusion of massive systems is briefly recapitulated, which clar- ifies the mechanism of so-called fusion hindrance. Since the neck changes the potential landscape, especially the height of the conditional saddle point, time evolution of the neck degree of freedom plays a crucial role in fusion. We analytically solve time-evolution of nuclear shape of the composite system from di-nucleus to mono-nucleus. The time- dependent distribution function of...

  9. On mono-W signatures in spin-1 simplified models

    Directory of Open Access Journals (Sweden)

    Ulrich Haisch

    2016-09-01

    Full Text Available The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artifact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  10. On Mono-W Signatures in Spin-1 Simplified Models

    CERN Document Server

    Haisch, Ulrich; Tait, Tim M. P.

    2016-09-10

    The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artefact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  11. Fondamenti di fisica dei plasmi

    CERN Document Server

    Golant, V E; Sacharov, I E

    1983-01-01

    Introduzione ; collisioni del plasma ; equazioni cinetiche per particelle cariche ; plasmi in equilibrio termodinamico ; funzione di distribuzione di particelle cariche in un campo elettrico ; equazioni dei momenti della funzione di distribuzione ; processi di trasporto nel plasma in assenza di campi magnetici ; moto di particelle cariche nel plasma in presenza di campi magnetici ; processi di trasporto in campo magnetico ; confinamento del plasma mediante campi magnetici.

  12. Temperature dependences of the retention indices of mono- and polyethylene glycol acetals and ethers on stationary phase DB-1 and enthalpies of their sorption from the gas phase

    Science.gov (United States)

    Zhabina, A. A.; Krasnykh, E. L.

    2017-12-01

    Gas chromatography is used to study the sorption characteristics and retention of a series of mono-, di-, and triethylene glycol ethers on nonpolar phase DB-1 in the temperature range of 70-180°C. Temperature dependences of the retention indices of the compounds are obtained and their linear character in the investigated range of temperatures is demonstrated. The enthalpies of sorption of the investigated compounds are calculated and analyzed, based on the temperature dependences of the retention factors.

  13. Tecniche di indagine in materia di mafia

    Directory of Open Access Journals (Sweden)

    Giovanni Falcone

    2015-07-01

    Full Text Available Si ripubblica qui il testo della Relazione che Giovanni Falcone e Giuliano Turone, uno giudice palermitano, l’altro giudice milanese, entrambi impegnati contro la criminalità mafiosa, tennero in un convegno a Castel Gandolfo nel giugno del 1982, tra l’assassinio di Pio La Torre e quello di Carlo Alberto dalla Chiesa. Si tratta di una relazione storica, che ha orientato più generazione di studiosi, soprattutto per la distinzione proposta sui tre livelli dei delitti di mafia.

  14. High pressure behaviour of uranium mono pnictides

    International Nuclear Information System (INIS)

    Pagare, Gitanjali; Ojha, Poonam; Sanyal, S.P.; Aynyas, Mahendra

    2006-01-01

    The pressure induced structural phase transition of three actinide mono pnictides AX (A=U and X=As, Sb, Bi), have been studied theoretically using two body interionic potential with necessary modifications to include the effect of Coulomb screening by the delocalized 5f electrons of the actinide (uranium) ion. The peculiar properties of these compounds have been interpreted in terms of the hybridization of f electrons with the conduction band. The calculated compression curves are compared with the experimental results. These compounds exhibits first order crystallographic phase transition from their NaCl (B 1 ) phase to CsCl (B 2 ) phase at 17GPa, 9.5GPa and 5.3 GPa respectively. The NaCl phase possesses lower energy than CsCl phase and stable at ambient pressure. (author)

  15. Esercizi di analisi infinitesimale

    CERN Document Server

    Sbrana, Francesco

    1948-01-01

    Esercizi di ricapitolazione ; integrali delle funzioni di una variabile ; derivate e differenziali delle funzioni di più variabili ; integrali dipendenti da un parametro ; integrali curvilinei ; integrali doppi ; integrali multipli ; applicazioni geometriche varie ; equazioni differenziali ; alcuni esercizi sulle serie di Fourier ; cenni sul calcolo delle variazioni ; alcune funzioni analitiche.

  16. Plasma etching on large-area mono-, multi- and quasi-mono crystalline silicon

    DEFF Research Database (Denmark)

    Davidsen, Rasmus Schmidt; Schmidt, Michael Stenbæk; Boisen, Anja

    2013-01-01

    using maskless RIE in a O2 and SF6 plasma, and the surface topology was optimized for solar cell applications by varying gas flows, pressure, power and process time. The starting substrates were 156x156 mm p-type, CZ mono-, multi- and quasi-mono crystalline Si wafers, respectively, with a thickness...... for AM 1.5 was used to calculate the weighted average reflectance in the wavelength range from 280-1000 nm. Our mask-less, scalable RIE nanostructuring of the Si surface is shown to reduce the AM1.5-weighted average reflectance to a level below 1 % in a fully optimized RIE texturing, and thus holds...

  17. Triangolo di pensieri

    CERN Document Server

    Connes, Alain; Schützenberger, Marcel Paul

    2001-01-01

    Le grandi scoperte scientifiche del XX secolo, come la relatività generale, la meccanica quantistica o il teorema di Godel, modificano profondamente la nostra percezione della realtà. Questo libro intende offrire a un pubblico largo, ma colto, la possibilità di superare il divario crescente fra le sottigliezze di queste modificazioni, apprezzate dai soli specialisti, e l'immagine spesso deformata che ne danno i media o le opere di divulgazione. Il libro cerca di dare delle risposte attraverso uno scambio di idee fra tre studiosi, ciascuno dei quali rappresenta un vertice del 'triangolo di pensieri'.

  18. Lezioni di Cosmologia Teorica

    CERN Document Server

    Gasperini, Maurizio

    2012-01-01

    Il libro è basato sulle lezioni attualmente tenute dall'autore presso l’Università di Bari, ed è progettato in modo da rappresentare un testo di riferimento il più possibile moderno, completo e autosufficiente per i corsi semestrale di Cosmologia, Astrofisica o Fisica Astroparticellare che compaiono nel piano di studi della Laurea Magistrale in Fisica e in Astronomia. Contiene gli elementi di base della cosmologia relativistica, del modello cosmologico standard e del suo completamento inflazionario. E' organizzato per servire da traccia ad un corso di cosmologia di stampo teorico, ma cerca di non perdere mai di vista il confronto con i principali risultati osservativi: molta attenzione viene infatti dedicata alla fenomenologia dei fondi cosmici, e in particolare alla  radiazione gravitazionale fossile perché la sua rivelazione, diretta o indiretta, potrebbe dare indicazioni  cruciali sulla scelta del corretto modello per l'Universo primordiale. Non mancano infine alcuni accenni ad argomenti di inter...

  19. Intercultural Interactions of Mono-Cultural, Mono-Lingual Local Students in Small Group Learning Activities: A Bourdieusian Analysis

    Science.gov (United States)

    Colvin, Cassandra; Fozdar, Farida; Volet, Simone

    2015-01-01

    This research examines the understandings and experiences of mono-cultural, mono-lingual local students in relation to intercultural interactions within small group learning activities at university. Bourdieu's concepts of field, habitus and capital are employed to illuminate a number of barriers to intercultural interaction. Using qualitative…

  20. Testa di Pinocchio

    OpenAIRE

    Moro, Liliana

    2017-01-01

    Testa di Pinocchio è il progetto proposto da Liliana Moro in occasione della mostra itinerante Playgrounds and Toys, organizzata dall’associazione con sede a Ginevra Art for the World e curata da Adelina von Fürstenberg, con l’intento di sensibilizzare il pubblico sul gioco come diritto fondamentale, spesso negato, di ogni bambino. In particolare la rassegna invitava artisti, architetti e designer di tutto il mondo a proporre progetti di parchi giochi e giocattoli destinati a bambini costrett...

  1. Sintesi stereoselettiva di piridilammine

    OpenAIRE

    Chelucci, Giorgio Adolfo; Baldino, Salvatore; Pinna, Gérard Aimé; Soccolini, Francesco

    2006-01-01

    Ammino piridine chirali hanno dimostrato la loro validità come leganti per la formazione di complessi metallici utilizzati nella catalisi asimmetrica. Tra i possibili approcci alla sintesi di questi composti noi abbiamo investigato la riduzione diastereoselettiva di N-sostituite (p-totil e tert-butil) piridil chetimmine con una serie di agenti riducenti (NaBH4, L-Selectride, DIBAL, 9-BBN) in diverse condizioni di reazione.

  2. Studio del danneggiamento mediante tomografia in luce del sincrotrone: impatto di un cono d’ombra sulla qualità finale delle ricostruzioni

    Directory of Open Access Journals (Sweden)

    Andrea Bernasconi

    2010-07-01

    Full Text Available Un’accurata osservazione della geometria tridimensionale di cricche e difetti è necessaria per lo studio dei meccanismi alla base del processo di danneggiamento. I metodi convenzionali utilizzati a questo scopo sono distruttivi o non possiedono una sufficiente risoluzione. Le tecniche di imaging che utilizzano la luce di sincrotrone, ed in particolare la microtomografia (micro-CT a raggi X, invece, uniscono i vantaggi di una tecnica non distruttiva ad un’elevata risoluzione spaziale e risultano quindi particolarmente interessanti. Un limite all’applicazione di questa tecnica è costituito dalla propensione della cricca a richiudersi una volta rimosso il carico che ha provocato il danneggiamento, superabile attraverso l’impiego di un dispositivo in grado di esercitare un carico di trazione durante l’acquisizione dei dati. Facendo riferimento al set-up sperimentale della linea SYRMEP di Elettra, il sincrotrone di Trieste, e tralasciando per il momento i vincoli legati a pesi e ingombri, è possibile pensare di inserire tra camera di ionizzazione e CCD una macchina per prove di trazione mono-colonna commerciale, in grado di mantenere aperto il difetto per tutta la durata della tomografia. In questo lavoro viene valutato l’impatto di questo vincolo sulla qualità finale delle ricostruzioni.

  3. Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

    Directory of Open Access Journals (Sweden)

    Stefano D'Errico

    2014-07-01

    Full Text Available The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyladenosine or a 1,6-di(adenosin-N6-yl-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamineplatinum(II, is reported. The chemistry exploits the high affinity of the charged platinum centres towards the N7 position of the adenosine base system and a primary amine of an alkyl chain installed on the C6 position of the purine. The cytotoxic behaviour of the synthesized complexes has been studied in A549 adenocarcinomic human alveolar basal epithelial and MCF7 human breast adenocarcinomic cancer cell lines, in order to investigate their effects on cell viability and proliferation.

  4. Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases

    Directory of Open Access Journals (Sweden)

    Andrea Bistrović

    2017-11-01

    Full Text Available A series of mono-pyrrolo[2,3-d]pyrimidines 4a–4k, unsymmetrical bis-purine isosteres 5a–5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolylphenyl linker were synthesized by click chemistry. Whereas mono- 4g and bis-pseudopurine 5e showed selective inhibitory activities on cervical carcinoma (HeLa cells, bis-pyrrolo[2,3-d]pyrimidine 6b exhibited potent and selective anti-proliferative effect in the nanomolar range on pancreatic carcinoma (CFPAC-1 cells. Among these, compound 6b induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma and p38 MAP (mitogen-activated protein kinases. Our findings encourage further development of novel structurally related analog of 6b to obtain more selective anticancer agent for treating pancreatic cancer.

  5. Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

    Science.gov (United States)

    Rosenthal, Florian; Feijs, Karla L H; Frugier, Emilie; Bonalli, Mario; Forst, Alexandra H; Imhof, Ralph; Winkler, Hans C; Fischer, David; Caflisch, Amedeo; Hassa, Paul O; Lüscher, Bernhard; Hottiger, Michael O

    2013-04-01

    ADP-ribosylation is an important post-translational protein modification (PTM) that regulates diverse biological processes. ADP-ribosyltransferase diphtheria toxin-like 10 (ARTD10, also known as PARP10) mono-ADP-ribosylates acidic side chains and is one of eighteen ADP-ribosyltransferases that catalyze mono- or poly-ADP-ribosylation of target proteins. Currently, no enzyme is known that reverses ARTD10-catalyzed mono-ADP-ribosylation. Here we report that ARTD10-modified targets are substrates for the macrodomain proteins MacroD1, MacroD2 and C6orf130 from Homo sapiens as well as for the macrodomain protein Af1521 from archaebacteria. Structural modeling and mutagenesis of MacroD1 and MacroD2 revealed a common core structure with Asp102 and His106 of MacroD2 implicated in the hydrolytic reaction. Notably, MacroD2 reversed the ARTD10-catalyzed, mono-ADP-ribose-mediated inhibition of glycogen synthase kinase 3β (GSK3β) in vitro and in cells, thus underlining the physiological and regulatory importance of mono-ADP-ribosylhydrolase activity. Our results establish macrodomain-containing proteins as mono-ADP-ribosylhydrolases and define a class of enzymes that renders mono-ADP-ribosylation a reversible modification.

  6. Professional Android Programming with Mono for Android and NETC#

    CERN Document Server

    McClure, Wallace B; Croft, John J; Dick, Jonathan; Hardy, Chris

    2012-01-01

    A one-of-a-kind book on Android application development with Mono for Android The wait is over! For the millions of .NET/C# developers who have been eagerly awaiting the book that will guide them through the white-hot field of Android application programming, this is the book. As the first guide to focus on Mono for Android, this must-have resource dives into writing applications against Mono with C# and compiling executables that run on the Android family of devices. Putting the proven Wrox Professional format into practice, the authors provide you with the knowledge you need to become a succ

  7. MONO FOR CROSS-PLATFORM CONTROL SYSTEM ENVIRONMENT

    International Nuclear Information System (INIS)

    Nishimura, Hiroshi; Timossi, Chris

    2006-01-01

    Mono is an independent implementation of the .NET Framework by Novell that runs on multiple operating systems (including Windows, Linux and Macintosh) and allows any .NET compatible application to run unmodified. For instance Mono can run programs with graphical user interfaces (GUI) developed with the C(number s ign) language on Windows with Visual Studio (a full port of WinForm for Mono is in progress). We present the results of tests we performed to evaluate the portability of our controls system .NET applications from MS Windows to Linux

  8. Travertine Hot Springs, Mono County, California

    Energy Technology Data Exchange (ETDEWEB)

    Chesterman, C.W.; Kleinhampl, F.J.

    1991-08-01

    This article is an abridgement of Special Report 172, Travertine Hot Springs at Bridgeport, Mono County, California, in preparation at the California Division of Mines and Geology. The Travertine Hot Springs area is on the northern edge of what many consider to be one of the most tectonically active areas in the United States. There is abundant geothermal and seismic activity. The landscape is dotted with volcanic features- cones, craters, domes, flows, fumaroles and hot springs-indicators of unrest in the present as well as reminders of activity in the past. Travertine, also known as calcareous sinter, is limestone formed by chemical precipitation of calcium carbonate (CaCO{sub 3}) from ground or surface waters. It forms stalactites and stalagmites in caves, fills some veins and spring conduits and can also be found at the mouths of springs, especially hot springs. The less compact variety is called tufa and the dense, banded variety is known as Mexican onyx, or onyx marble. True onyx, however, is a banded silicate.

  9. Elementi di teoria delle funzioni e di analisi funzionale

    CERN Document Server

    Kolmogorov, Andrej N

    1980-01-01

    Elementi di teoria degli insiemi ; spazi metrici e topologici ; spazi lineari topologici e normati ; funzionali e operatori lineari ; misura, funzioni misurabili, integrale ; integrale indefinito di Lesbegue, teoria della derivazione ; spazi di funzioni sommabili ; serie trigonometriche, trasformata di Fourier ; equazioni integrali lineari ; elementi di calcolo differenziale negli spazi lineari ; algebre di Banach.

  10. Bepaling van dapson, mono- en diacetyldapson in runderbloedplasma

    NARCIS (Netherlands)

    Reuver, de M.J.B.; Aerts, M.M.L.; Kuiper, H.A.

    1985-01-01

    Doel van dit onderzoek is: het testen van de bepalingsmetheden voor dapson, mono- en diacetyldapson in bloedplasma van melkgevende runderen en het vaststellen van het kinetisch profiel van genoemde stoffen na orale en intramusculaire toediening. Tevens wordt deglucuronidering en eiwitbinding

  11. Selective mono-alkylation of N-methoxybenzamides.

    Science.gov (United States)

    Chen, Zenghua; Hu, Le'an; Zeng, Fanyun; Zhu, Ranran; Zheng, Shasha; Yu, Qingzhen; Huang, Jianhui

    2017-04-11

    We report our latest discovery of norbornene derivative modulated highly mono-selective ortho-C-H activation alkylation reactions on arenes bearing simple mono-dentate coordinating groups. The reaction features the use of readily available benzamides and alkyl halides. During the study, we prepared 30 mono-alkylated aryl amides in good yields with good mono-selectivity. We have also demonstrated that structurally rigid alkenes such as norbornene and its derivatives are a good class of ligand and could be used for future direct C-H functionalizations. The utilization of norbornene type ligands for assistance in C-H activation processes has opened a new window for future molecular design using direct C-H functionalization strategies.

  12. Il maxiprocesso di Palermo

    Directory of Open Access Journals (Sweden)

    A cura di Sarah Mazzenzana

    2016-04-01

    La Torre. La “Rivista” ripubblica qui alcuni stralci dell’ordinanza di rinvio a giudizio, alla quale Giovanni Falcone e Paolo Borsellino attesero, per ragioni di sicurezza, rifugiati nell’isola dell’Asinara. Viene ricostruita la realtà disvelata dai racconti di Leonardo Vitale, di Giuseppe Di Cristina e soprattutto di Tommaso Buscetta e Salvatore Contorno. Sono brani che, anche riletti oggi, mantengono una propria potenza narrativa, perfino una certa solennità. Il Maxiprocesso si sarebbe chiuso dopo alterne vicende, il 30 gennaio del 1992, con la condanna all’ergastolo in Cassazione della cosiddetta Cupola di Cosa nostra. Per la prima volta in centotrent’anni di storia nazionale i boss mafiosi avrebbero conosciuto la condanna a vita in via definitiva. Dopo pochi mesi avrebbero risposto con le stragi, uccidendo platealmente i due principali estensori dell’ordinanza.

  13. Fatigue Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

    In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...... of the natural period, damping ratio, current, stress Spectrum and parameters describing the fatigue strength. Further, soil damping is shown to be significant for the Mono-tower....

  14. Testimonianze di vittime degli anni di piombo

    DEFF Research Database (Denmark)

    Cecchini, Leonardo

    Testimonianze di vittime degli anni di piombo In un articolo pubblicato nel 2008 sulla webzine Nazione indiana Christian Raimo criticava quello che poi Giovanni De Luna qualche anno dopo nel suo libro La Repubblica del dolore (2011) ha chiamato “paradigma vittimario”; cioè la presenza predominante...

  15. Nella stanza di Asperger...

    OpenAIRE

    Alessandra Gilardini

    2011-01-01

    Gli studi sulla struttura del cervello di persone con Asperger avrebbero mostrato una diversa conformazione del lobo parietale (deputato all’elaborazione di soluzioni ai problemi), del lobo temporale mediale (sede della memoria a lungo termine) e del cervelletto (coordinatore del movimento corporeo). Queste differenze possono spiegare le capacità a volte geniali di questi bambini e di questi adulti, oltre alla caratteristica ritualità nei gesti che li accompagna nel quotidiano.

  16. 21 CFR 184.1521 - Monosodium phosphate derivatives of mono- and diglycerides.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Monosodium phosphate derivatives of mono- and... derivatives of mono- and diglycerides. (a) Monosodium phophate derivatives of mono- and diglycerides are composed of glyceride derivatives formed by reacting mono- and diglycerides that are derived from edible...

  17. 21 CFR 184.1101 - Diacetyl tartaric acid esters of mono- and diglycerides.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Diacetyl tartaric acid esters of mono- and... acid esters of mono- and diglycerides. (a) Diacetyl tartaric acid esters of mono- and diglycerides... prepared by the reaction of diacetyl tartaric anhydride with mono- and diglycerides that are derived from...

  18. Problemi di Fisica

    CERN Document Server

    Fazio, Michelangelo

    2008-01-01

    L’introduzione delle lauree triennali ha in molti casi costretto i docenti a ridurre drasticamente il numero di ore di insegnamento e quindi l’estensione dei programmi dei corsi di Fisica. In questo volumetto l'autore si è proposto di esporre sinteticamente ma con il massimo rigore possibile il corso di Fisica Generale I evitando le dimostrazioni delle leggi fisiche, ma dando la priorità alle applicazioni di tali leggi e allo svolgimento di esercizi che in genere viene trascurato in molti corsi. Ha cercato pertanto di presentare i fenomeni fisici sottolineando, dove possibile, la loro presenza nella vita quotidiana e le loro più semplici e immediate applicazioni, consentendo in tal modo agli studenti di vedere la Fisica non più come una interminabile serie di formule ma come un nuovo modo di interpretare e di capire i fenomeni naturali inanimati (del resto non dobbiamo dimenticare che il termine greco da cui deriva il suo nome è fisis, fisis, ovvero natura). Il contenuto è completo, comprendendo anc...

  19. Il Cratilo di Platone

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2015-06-01

    Full Text Available La guida ipertestuale alla lettura del Cratilo di Platone composta per gli studenti della facoltà di Scienze politiche dell’università di Pisa è ora visibile a tutti qui. L’ipertesto ha tratto vantaggio dall’Introduzione alla linguistica generale del professor Manuel Barbera dell’università...

  20. Electron transfer reactions in the alkene mono-oxygenase complex from Nocardia corallina B-276.

    Science.gov (United States)

    Gallagher, S C; Cammack, R; Dalton, H

    1999-04-01

    Nocardia corallina B-276 possesses a multi-component enzyme, alkene mono-oxygenase (AMO), that catalyses the stereoselective epoxygenation of alkenes. The reductase component of this system has been shown by EPR and fluorescence spectroscopy to contain two prosthetic groups, an FAD centre and a [2Fe-2S] cluster. The role of these centres in the epoxygenation reaction was determined by midpoint potential measurements and electron transfer kinetics. The order of potentials of the prosthetic groups of the reductase were FAD/FAD.=-216 mV, [2Fe-2S]/[2Fe-2S].=-160 mV and FAD./FAD.=-134 mV. Combined, these data implied that the reductase component supplied the energy required for the epoxygenation reaction and allowed a prediction of the mechanism of electron transfer within the AMO complex. The FAD moiety was reduced by bound NADH in a two-electron reaction. The electrons were then transported to the [2Fe-2S] centre one at a time, which in turn reduced the di-iron centre of the epoxygenase. Reduction of the di-iron centre is required for oxygen binding and substrate oxidation.

  1. Searching for Dark Matter in the Mono-Jet and Mono-Photon Channels with the ATLAS Detector

    CERN Document Server

    Ratti, Maria Giulia; Carminati, Leonardo

    This work presents searches for dark matter particles in the mono-jet and mono-photon final states using the data collected by the ATLAS experiment during 2015 and 2016. The thesis starts with an introduction to the basic concepts of the Standard Model, followed by a discussion of the dark matter problem and the WIMP hypothesis. The focus then shifts to the description of the experimental facilities to collect the data and reconstruct the collision events. Particular focus is put on the reconstruction and performance of the missing transverse momentum. After characterizing a few theoretical models predicting dark matter particles in the mono-photon and mono-jet final states, the searches in these two signatures are thoroughly discussed, with particular focus on the background estimation techniques. While no significant deviations from the Standard Model predictions are found, the results obtained by these searches further restrict the phase-space where the dark matter particles can lie.

  2. Analisi di un campione significativo di Learning Objects.

    Directory of Open Access Journals (Sweden)

    Luigi Guerra

    2006-01-01

    Full Text Available Il lavoro analizza sul piano pedagogico e didattico il concetto di Learning Object (LO a partire dalla rilevazione diretta dei modelli formativi sottostanti, in forma esplicita o implicita, un campione significativo di Learning Objects identificato all’interno di rilevanti esperienze di e-learning universitarie e non universitarie prodotte in diverse nazioni, allo scopo di giungere alla messa a punto di una modellistica problematica di tipo didattico dei Learning Objects, funzionale alla costruzione di algoritmi differenziati di progettazione, realizzazione, erogazione e valutazione di LO, anche nella prospettiva dei Learning Artifacts.

  3. Influence of structure on electrochemical reduction of isomeric mono- and di-, nitro- or nitrosocalix[4]arenes

    Czech Academy of Sciences Publication Activity Database

    Liška, Alan; Flídrová, K.; Lhoták, P.; Ludvík, Jiří

    2015-01-01

    Roč. 146, č. 5 (2015), s. 857-862 ISSN 0026-9247 R&D Projects: GA ČR GA13-21704S Institutional support: RVO:61388955 Keywords : Electrochemical reduction * Nitrocalix[4]arenes * Nitrosocalix[4]arenes Subject RIV: CG - Electrochemistry Impact factor: 1.131, year: 2015

  4. Geometric and electronic structures of mono- and di-vacancies in phosphorene.

    Science.gov (United States)

    Hu, Ting; Dong, Jinming

    2015-02-13

    The geometric structures, stabilities and diffusions of the monovacancy (MV) and divacancy (DV) in two-dimensional phosphorene, as well as their influences on their vibrational and electronic properties have been studied by first-principles calculations. Two possible MVs and 14 possible DVs have been found in phosphorene, in which the MV-(5|9) with a pair of pentagon-nonagon is the ground state of MVs, and the DV-(5|8|5) with a pentagon-octagon-pentagon structure is the most stable DV. All 14 DVs could be divided into four basic types based upon their topological structures and transform between different configurations via bond rotations. The diffusion of MV-(5|9) is found to exhibit an anisotropic character, preferring to migrate along the zigzag direction in the same half-layer. The introduction of MV and DV in phosphorene influences its vibrational properties, inducing the localized defect modes, which could be used to distinguish different vacancy structures. The MVs and DVs also have a significant influence on the electronic properties of phosphorene. It is found that the phosphorene with MV-(5|9) is a ferromagnetic semiconductor with the magnetic moment of 1.0 μB and a band gap of about 0.211 eV, while the DV induces a direct-indirect band gap transition. Our calculation results on the MV and DV in phosphorene are important for the promising application of the phosphorene in the nanoelectronics.

  5. Synthesis and cell imaging applications of fluorescent mono/di/tri-heterocyclyl-2,6-dicyanoanilines.

    Science.gov (United States)

    Pisal, Mahesh M; Annadate, Ritesh A; Athalye, Meghana C; Kumar, Deepak; Chavan, Subhash P; Sarkar, Dhiman; Borate, Hanumant B

    2017-02-15

    Synthesis of 3,4,5-triheterocyclyl-2,6-dicyanoanilines, starting from heterocyclic aldehydes and 1,2-diheterocycle-substituted ethanones, is described. 2,6-Dicyanoanilines with one or two heterocyclic substituents have also been synthesized. It was found that some of these molecules have selective cell-staining properties useful for cell imaging applications. The compounds 1g, 10f and 11 were found to stain cytoplasm of the cells in contact but not the nucleus while the compound 12 showed affinity to apoptotic cells resulting in blue fluorescence. The cell imaging results with compound 12 were similar to Annexin V-FITC, a known reagent containing recombinant Annexin V conjugated to green-fluorescent FITC dye, used for detection of apoptotic cells. These compounds were found to be non-cytotoxic and have potential application as cell imaging agents. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Effect of Mono-and Di-hydration on the Intramolecular Proton ...

    Indian Academy of Sciences (India)

    Structural and thermodynamic properties of 10 isomers of cyanuric acid were studied in aqueous and gas phases, employing B3LYP/6-311++G(d,p) method. The aromaticities of these isomers were evaluated using nucleus-independent chemical shift (NICS) index. The calculations showed that as the number of the ...

  7. Electron impact single ionization of mono- and di-positive ions

    Indian Academy of Sciences (India)

    difficult to apply in many cases, the present MBED model, with its inherent sim- plicity, can generate sufficiently accurate data for various applications, and is a prudent alternative for rapid calculations of the EII cross-sections. References. [1] M A Uddin, A K Basak, A K M A Islam and F B Malik, J. Phys. B37, 1909 (2004).

  8. Mono-, di-, and trimetallic methacrylate-substituted metal oxide clusters derived from hafnium butoxide

    International Nuclear Information System (INIS)

    Gross, Silvia; Kickelbick, Guido; Puchberger, Michael; Schubert, Ulrich

    2003-01-01

    The methacrylate-substituted clusters Hf 4 O 2 (OMc) 12 , Hf 6 O 4 (OH) 4 (OMc) 12 (BuOH), Ti 4 Hf 4 O 6 (OBu) 4 (OMc) 16 , andTi 2 Zr 5 HfO 6 (OMc) 20 (OMc = methacrylate) were prepared by reacting Hf(OBu) 4 , or Hf(OBu) 4 /Ti(OBu) 4 and Hf(OBu) 4 /Zr(OBu) 4 /Ti(OBu) 4 mixtures, respectively, with methacrylic acid. All clusters were characterized by x-ray structure analyses and are basically isostructural, although not in each case isomorphous, with the corresponding oxozirconium clusters. Low-temperature NMR studies revealed that the methacrylate ligands of Hf 4 O 2 (OMc) 12 are highly dynamic even at - 80 o C. Refs. 10 (author)

  9. Performance of selected microbial pectinases on synthetic mono-methylesterified di- and trigalacturonates

    NARCIS (Netherlands)

    Kester, H.C.M.; Magaud, D.; Roy, C.; Anker, D.; Doutheau, A.; Shevchik, V.; Hugouvieux-Cotte-Pattat, N.; Benen, J.A.E.; Visser, J.

    1999-01-01

    Two monomethyl esters of -(1-4)-linked D-galacturonic dimers and three monomethyl esters of -(1-4)-linked D-galacturonic acid trimers were synthesized chemically and further used as substrates in order to establish the substrate specificity of six different endopolygalacturonases from Aspergillus

  10. Autobiografia di un fisico

    CERN Document Server

    Born, Max

    1980-01-01

    Questa non è solo un'autobiografia scientifica. Il ritratto che Max Born ci offre di se stesso va oltre il profilo dell'uomo di scienza, che pure è stato tra i maggiori del nostro secolo. Di lui veniamo a sapere tutto ciò che occorre per accostarsi alle teorie che gli valsero il premio Nobel, ma anche i tratti di una normale vita borghese nella quale si intrecciavano le influenze dell'ambiente intellettuale e commerciale. Il tono è quello di una rievocazione piana e distesa che ci accompagna per le varie fasi della carriera dello studente, del docente, dello scienziato, nelle università tedesche e inglesi, negli anni delle persecuzioni naziste, alle quali l'ebreo Max Born ebbe la fortuna di sopravvivere, e nel dopoguerra, quando egli tornò in Germania e seppe dare un contributo di idee e di iniziative ai movimenti pacifisti. E' la lunga e operosa vita di un uomo di genio, del quale si ricorda la profonda umanità, la vastità degli interessi culturali, l'acutezza dei giudizi sulle persone, sulle vicend...

  11. Esercizi scelti di algebra

    CERN Document Server

    Chirivì, Rocco; Dvornicich, Roberto

    2017-01-01

    Questo libro – primo di due volumi -  presenta oltre 250 esercizi scelti di algebra ricavati dai compiti d'esame dei corsi di Aritmetica tenuti dagli autori all'Università di Pisa. Ogni esercizio viene presentato con una o più soluzioni accuratamente redatte con linguaggio e notazioni uniformi. Caratteristica distintiva del libro è che gli esercizi proposti sono tutti diversi uno dall'altro e le soluzioni richiedono sempre una piccola idea originale; ciò rende il libro unico nel genere. Gli argomenti di questo primo volume sono: principio d'induzione, combinatoria, congruenze, gruppi abeliani, anelli commutativi, polinomi, estensioni di campi, campi finiti. Il libro contiene inoltre una dettagliata sezione di richiami teorici e può essere usato come libro di riferimento per lo studio. Una serie di esercizi preliminari introduce le tecniche principali da usare per confrontarsi con i testi d'esame proposti. Il volume è rivolto a tutti gli studenti del primo anno dei corsi di laur ea in Matematica e Inf...

  12. Introduzione alle teorie di gauge

    CERN Document Server

    Cabibbo, Nicola; Benhar, Omar

    2016-01-01

    "Introduzione alle Teorie di Gauge" completa la serie di tre volumi basati sulle lezioni dei corsi di Meccanica Quantistica Relativistica, Interazioni Elettrodeboli e Teorie di Gauge, impartite dagli autori agli studenti delle Lauree Magistrali in Fisica e Astronomia & Astrofisica dell'Universita "La Sapienza" di Roma, nell'arco di qualche decennio. L'obiettivo principale del volume è di introdurre i concetti di base della rinormalizzazione nella teoria quantistica dei campi e i fondamenti delle moderne teorie di Gauge. Anche se collegato ai volumi precedenti, il libro si presta ad una lettura indipendente, che presume solo conoscenze generali di relativita speciale, della seconda quantizzazione e della fenomenologia delle interazioni elettrodeboli. Lo strumento di base è l'integrale sui cammini di Feynman, introdotto nei capitoli iniziali e sistematicamente impiegato nel seguito. L'esposizione segue un percorso pedagogico, che parte dal caso semplice dell'ampiezza di transizione in meccanica quantistic...

  13. Transient Monotonic and Cyclic Load Effects on Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Nielsen, Søren Dam

    Today, 80 % of all European offshore wind turbines are installed on monopiles. A cost-effective alternative to the monopile is the mono bucket foundation. For an offshore wind turbine foundation in open seas, the dominant load is often coming from waves. During storms, large waves are formed...... and when hitting the foundation they induce high impact loads with a short duration. It is important that the foundation is able to resists these huge loads. Fortunately, the conducted research showed that the capacity of the mono bucket foundation is high to impact loads. When exposed to a huge wave load...... accumulating for each wave impact. The presented research has shown indications that only the first waves contribute to the permanent rotation. These indications are seen in small-scale laboratory tests and on a full-scale mono bucket foundation....

  14. Cost-Effective Mass Production of Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Gres, Szymon; Nielsen, Søren Andreas; Fejerskov, Morten

    2015-01-01

    No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution for inno......No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution...... for innovative and cost-effective design of Mono Bucket foundations. Established approach merges wind and wave load models, soil/structure interaction topics, structural optimization and installation/fabrication aspects, into software package with ability to perform optimal design of the individual foundations...

  15. Mono- and co-substrate utilization kinetics using mono- and co-culture of Clostridium beijerinckii and Clostridium saccharoperbutylacetonicum.

    Science.gov (United States)

    Nasr, Noha; Gupta, Medhavi; Hafez, Hisham; El Naggar, M Hesham; Nakhla, George

    2017-10-01

    The effect of co-culturing C. beijerinckii and C. saccharoperbutylacetonicum for H 2 production using mono- and co-substrates of glucose, starch, and cellulose was assessed. Monod kinetic parameters (K, maximum specific substrate utilization rate; and K s , half-saturation constant) of the C. beijerinckii, C. saccharoperbutylacetonicum, and the co-culture were determined. Co-cultures utilizing glucose competed for the substrate, but showed enhancement for utilizing starch. The maximum values for K on glucose and starch were 0.48g substrate/gVSS.h achieved by C. saccharoperbutylacetonicum mono-culture and 0.39g substrate/gVSS.h achieved by the co-culture, respectively. The average K s for all mono- and co-culture experiments was 0.93±0.03g/L. Acetate, butyrate, and propionate were the main fermentation products for all experiments. Maximum H 2 production yields on glucose (2.69mol/mol glucose ) and starch (1.07mol/mol hexose ) were achieved by C. beijerinckii and C. saccharoperbutylacetonicum mono-cultures, respectively; however, neither culture was able to degrade cellulose as a mono-substrate. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Effect of Mono- and Poly-CH/P Exchange(s on the Aromaticity of the Tropylium Ion

    Directory of Open Access Journals (Sweden)

    Ankita Puri

    2016-08-01

    Full Text Available In view of the fact that the phosphorus atom in its low co-ordination state (coordination numbers 1 and 2 has been termed as the carbon copy, there have been attempts to investigate, theoretically as well as experimentally, the effect of the exchange(s of CH- moiety with phosphorus atom(s (CH/P on the structural and other aspects of the classical carbocyclic and heterocyclic systems. Tropylium ion is a well-known non-benzenoid aromatic system and has been studied extensively for its aromatic character. We have now investigated the effect of mono- and poly-CH/P exchange(s on the aromaticity of the tropylium ion. For this purpose, the parameters based on the geometry and magnetic properties, namely bond equalization, aromatic stabilization energies (ASE, Nucleus-Independent Chemical Shift (NICS values, (NICS(0, NICS(1, NICS(1zz, proton nucleus magnetic resonance (1H-NMR chemical shifts, magnetic susceptibility exaltation and magnetic anisotropic values of mono-, di-, tri- and tetra-phosphatropylium ions have been determined at the Density Functional Theory (DFT (B3LYP/6-31+G(d level. Geometry optimization reveals bond length equalization. ASEs range from −46.3 kcal/mol to −6.2 kcal/mol in mono- and diphospha-analogues which are planar. However, the ions having three and four phosphorus atoms lose planarity and their ASE values approach the values typical for non-aromatic structures. Of the three NICS values, the NICS(1zz is consistently negative showing aromatic character of all the systems studied. It is also supported by the magnetic susceptibility exaltations and magnetic anisotropic values. Furthermore, 1H-NMR chemical shifts also fall in the aromatic region. The conclusion that mono-, di-, tri- and tetra-phosphatropylium ions are aromatic in nature has been further corroborated by determining the energy gap between the Highest Occupied Molecular Orbital (HOMO and Lowest Unoccupied Molecular Orbital (LUMO (HOMO − LUMO gap, which falls in

  17. Effect of Mono- and Poly-CH/P Exchange(s) on the Aromaticity of the Tropylium Ion.

    Science.gov (United States)

    Puri, Ankita; Gupta, Raakhi

    2016-08-20

    In view of the fact that the phosphorus atom in its low co-ordination state (coordination numbers 1 and 2) has been termed as the carbon copy, there have been attempts to investigate, theoretically as well as experimentally, the effect of the exchange(s) of CH- moiety with phosphorus atom(s) (CH/P) on the structural and other aspects of the classical carbocyclic and heterocyclic systems. Tropylium ion is a well-known non-benzenoid aromatic system and has been studied extensively for its aromatic character. We have now investigated the effect of mono- and poly-CH/P exchange(s) on the aromaticity of the tropylium ion. For this purpose, the parameters based on the geometry and magnetic properties, namely bond equalization, aromatic stabilization energies (ASE), Nucleus-Independent Chemical Shift (NICS) values, (NICS(0), NICS(1), NICS(1)zz), proton nucleus magnetic resonance (¹H-NMR) chemical shifts, magnetic susceptibility exaltation and magnetic anisotropic values of mono-, di-, tri- and tetra-phosphatropylium ions have been determined at the Density Functional Theory (DFT) (B3LYP/6-31+G(d)) level. Geometry optimization reveals bond length equalization. ASEs range from -46.3 kcal/mol to -6.2 kcal/mol in mono- and diphospha-analogues which are planar. However, the ions having three and four phosphorus atoms lose planarity and their ASE values approach the values typical for non-aromatic structures. Of the three NICS values, the NICS(1)zz is consistently negative showing aromatic character of all the systems studied. It is also supported by the magnetic susceptibility exaltations and magnetic anisotropic values. Furthermore, ¹H-NMR chemical shifts also fall in the aromatic region. The conclusion that mono-, di-, tri- and tetra-phosphatropylium ions are aromatic in nature has been further corroborated by determining the energy gap between the Highest Occupied Molecular Orbital (HOMO) and Lowest Unoccupied Molecular Orbital (LUMO) (HOMO - LUMO gap), which falls in the

  18. RICERCHE DI STATISTICA METEOROLOGICA

    Directory of Open Access Journals (Sweden)

    EZIO ROSINI

    1956-06-01

    Full Text Available statistica
    non ha goduto di buona stampa nel passato anche recente; particolarmente
    poco apprezzata è stata la statistica meteorologica e climatologica.
    Occorre riconoscere che tale atteggiamento era almeno in
    parte frutto di un preconcetto errato sul significato della statistica, ma
    che d'altra parte la natura dei lavori di tal genere che venivano alla
    luce sembrava a volte confermare la giustezza del preconcetto. Il fatto
    è che una parte degli studiosi di meteorologia avvertiva più di altri,
    probabilmente per la propria stessa costituzione mentale, l'astrattezza
    dei metodi fisico-matematici applicati alla grandiosa e al tempo stesso
    minuta complessità dei fenomeni meteorologici, sentendo dunque maggiormente
    la necessità di far costante ricorso alla realtà delle osservazioni
    effettivamente eseguite.

  19. La flotta di Classe

    OpenAIRE

    Gnoli, Tommaso

    2003-01-01

    Testo di una conferenza tenuta a Ravenna il 17 gennaio 2003. La flotta imperiale romana di Classe è presentata nel suo contesto storico e istituzionale. Inquadramento della condizione dei classiarii nell'ambito più generale dell'esercito romano. Ipotesi e problemi sullo sviluppo dell'area ravennate in età imperiale in rapporto all'installazione di questa grande unità militare.

  20. Synthesis and spectroscopic study of nitroxide mono- and bi- radicals

    International Nuclear Information System (INIS)

    Michon, Pierre

    1970-01-01

    Synthesis and study of nitroxide mono- and bi- radicals derived from oxazolidine: - The first part is the synthesis of amines and radicals, and the I.R. U.V., E.P.R. spectroscopy study. - Conformational analysis of two biradicals has been carried out by measurement of dipolar interaction, on the E.P.R. spectra in the second part. - The final part is an application of N.M.R. study to the determination of the sign and magnitude of nuclear-electron spin-spin couplings and conformations analysis in five mono-radicals. (author) [fr

  1. Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Enevoldsen, I.; Sørensen, John Dalsgaard

    In this paper a reliability analysis of a Mono-tower platform is presented. The failure modes, considered, are yelding in the tube cross-sections, and fatigue failure in the butt welds. The fatigue failure mode is investigated with a fatigue model, where the fatigue strength is expressed through SN...... for the fatigue limit state is a significant failure mode for the Mono.tower platform. Further, it is shown for the fatigue failure mode the the largest contributions to the overall uncertainty are due to the damping ratio, the inertia coefficient, the stress concentration factor, the model uncertainties...

  2. Structural characterization and surface-active properties of a new glycolipid biosurfactant, mono-acylated mannosylerythritol lipid, produced from glucose by Pseudozyma antarctica.

    Science.gov (United States)

    Fukuoka, Tokuma; Morita, Tomotake; Konishi, Masaaki; Imura, Tomohiro; Sakai, Hideki; Kitamoto, Dai

    2007-09-01

    Mannosylerythritol lipids (MELs), which are glycolipid biosurfactants produced by Pseudozyma yeasts, show not only excellent interfacial properties but also versatile biochemical actions. In the course of MEL production from glucose as the sole carbon source, P. antarctica was found to produce unknown glycolipids more hydrophilic than conventional "di-acylated MELs," which have two fatty acyl esters on the mannose moiety. Based on a detailed characterization, the most hydrophilic one was identified as 4-O-(3'-O-alka(e)noyl-beta-D: -mannopyranosyl)-D: -erythritol namely, "mono-acylated MEL." The mono-acylated MEL reduced the surface tension of water to 33.8 mN/m at a critical micelle concentration (CMC) of 3.6 x 10(-4) M, and its hydrophilic-lipophilic balance was tentatively calculated to be 12.15. The observed CMC was 100-fold higher than that of the MELs hitherto reported. Interestingly, of the yeast strains of the genus Pseudozyma, only P. antarctica and P. parantarctica gave the mono-acylated MEL from glucose, despite a great diversity of di-acylated MEL producers in the genus. These strains produced MELs including the mono-acylated one at a rate of 20-25%. From these results, the new MEL is likely to have great potential for use in oil-in-water-type emulsifiers and washing detergents because of its higher water solubility compared to conventional MELs and will thus contribute to facilitating a broad range of applications for the environmentally advanced surfactants.

  3. Progetto QUADIS (Qualit di Servizio)

    CERN Document Server

    Ferrari, T; Vistoli, C

    1999-01-01

    Le applicazioni distribuite di nuova generazione richiedono servizi di rete garantiti. La rete Internet fornisce tuttora un servizio di tipo ³best effort² e perciò non adatto a soddisfare le nuove esigenze che provengono dalle $9 applicazioni. E' necessario studiare nuove architetture che facciano interagire applicazioni e rete in modo più stretto per ottenere più garanzie di affidabilit ed efficienza.Questo documento introduce i concetti base della qualit di $9 servizio sulla rete e i meccanismi in fase di studio o di sperimentazione finora esistenti. Definisce inoltre un programma di lavoro che prevede l'analisi di alcune applicazioni specifiche dell'INFN e la sperimentazione di servizi di $9 rete QoS adatti all'applicazione in esame.Questo documento è allegato al progetto "QUAdiS" di Gruppo V.

  4. Reti di città, mobilità e ambiente: il Preliminare di PTCP di Avellino

    Directory of Open Access Journals (Sweden)

    Carmela Gargiulo

    2010-02-01

    Full Text Available  L’articolo propone la lettura dei contenuti del Preliminare del PTCP di Avellino, un piano per molti aspetti innovativo, soprattutto per aver coniugato pianificazione di area vasta di tipo tradizionale e logica “strategica”. In particolare, l’articolo descrive idee guida, contenuti e strategie del piano orientate, prevalentemente, a stimolare lo sviluppo sostenibile di un’area in ritardo di sviluppo come la provincia irpina, attraverso la salvaguardia e valorizzazione delle risorse naturali e storico-culturali, la costruzione di reti di medie e piccole città e reti di mobilità alle diverse scale, da quella urbana a quella internazionale, e interventi sul sistema della mobilità. Nel 2004, ormai più di cinque anni fa, è stato adottato, a maggioranza assoluta (solo due gli astenuti, il Preliminare di Piano Territoriale di Coordinamento della Provincia di Avellino, dopo un lavoro di oltre due anni che ha visto impegnati gli uffici provinciali con due dipartimenti universitari. Il lavoro, che va ben oltre il significato e la valenza di un preliminare e che coniuga due pratiche di piano diverse (quella tradizionale e quella strategica ruota attorno a tre idee di fondo, tra loro strettamente interrelate, che costituiscono i criteri guida che finora ha inteso seguire la provincia di Avellino nell’attività di governo delle trasformazioni. Tali idee, quindi, costituiscono le fondamenta su cui è stato costruito il Preliminare e sono la griglia di specificazione delle strategie e degli obiettivi di piano. Esse sono alla base delle scelte elaborate per lo sviluppo compatibile del territorio, e sono riferibili alle azioni operative di trasformazione del territorio che gli Enti locali, cui è demandato tale compito, nel prossimo futuro dovranno affrontare. Le tre idee forza del Preliminare, descritte nel seguito, sono riferibili ai sistemi di risorse principali della provincia di Avellino, oggetto di una indagine analitico

  5. Risperidone Mono - Therapy as Prophylaxis in Bipolar Affective Disorders

    OpenAIRE

    Trivedi, Mohit; Pinto, Denzil; Safeekh, A.T.

    2004-01-01

    Risperidone has been found to be useful in the treatment of acute bipolar disorders. This is a case report where risperidone mono therapy has been found to be effective in prophylaxis of bipolar affective disorder. The pharmacological and clinical implications of risperidone in the management of BPAD are discussed

  6. Synthesis and Characterization of Some Mono Chloro-S- Triazine ...

    African Journals Online (AJOL)

    A series of ten bifunctional mono-chloro-s-triazine vinyl sulphone reactive dyes were synthesized based on Hacid with varied substituents coded as (BRD). These dyes were characterized by IR spectroscopy. The results revealed an incorporation of various substituents. The visible absorption spectra of these dyes were ...

  7. Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Enevoldsen, I.; Sørensen, John Dalsgaard

    1990-01-01

    In this paper, a reliability analysis of a Mono-tower platform is presented. Te failure modes considered are yielding in the tube cross sections and fatigue failure in the butts welds. The fatigue failrue mode is investigated with a fatigue model, where the fatigue strength is expressed through SN...

  8. Production of mono sugar from acid hydrolysis of seaweed | Jang ...

    African Journals Online (AJOL)

    The purpose of this work was to optimize the process conditions for the saccharification of macroalgae (seaweed) into mono sugar using the following parameters such as: Amount of biomass, catalyst concentration, temperature and reaction time. The major component of Ulva pertusa (green seaweed), Laminaria japonica ...

  9. Air quality in bedded mono-slope beef barns

    Science.gov (United States)

    Bedded mono-slope barns are becoming more common in the upper Midwest. Because these are new facilities, little research has been published regarding environmental quality, building management and animal performance in these facilities. A team of researchers from South Dakota State University, USDA ...

  10. Mono-fermentation of shea waste in anaerobic digesters - laboratory ...

    African Journals Online (AJOL)

    For the purpose of understanding the characteristics in performance of the shea waste and to provide the necessary input parameters towards the design of biogas plants, mono-fermentation as an option in anaerobic digestion for energy (methane) generation was investigated. Six horizontal reactors with a liquid volume of ...

  11. Mono Drama: Categorization and Theoretical Scaffolds in the ...

    African Journals Online (AJOL)

    It is against this background that this study attempts to investigate very vital issues concerning mono drama, which include: the concept of Solo drama in creative and performance contexts, taxonomy of solo/monodrama as well as the deployment of appropriate theories that should be applied by both solo drama writers and ...

  12. Reversible mono-ADP-ribosylation of DNA breaks.

    Science.gov (United States)

    Munnur, Deeksha; Ahel, Ivan

    2017-12-01

    Adenosine diphosphate (ADP)-ribosylation is a chemical modification of macromolecules that plays an important role in regulation of quintessential biological processes such as DNA repair, transcription, chromatin remodelling, stress response, apoptosis, bacterial metabolism and many others. ADP-ribosylation is carried out by ADP-ribosyltransferase proteins, such as poly (ADP-ribose) polymerases (PARPs) that transfer either monomer or polymers of ADP-ribose onto the molecular targets by using nicotinamide adenine dinucleotide (NAD + ) as a cofactor. Traditionally, proteins have been described as primary targets of ADP-ribosylation; however, there has been growing evidence that DNA may be a common target as well. Here, we show using biochemical studies that PARP3, a DNA damage-activated ADP-ribosyltransferase, can mono-ADP-ribosylate double-stranded DNA ends. ADP-ribosylation of DNA mediated by PARP3 attaches a single mono-ADP-ribose moiety to the phosphate group at the terminal ends of DNA. We further show that mono ADP-ribosylation at DNA ends can be efficiently reversed by several cellular hydrolases (PARG, MACROD2, TARG1 and ARH3). This suggests that mono ADP-ribosylated DNA adducts can be efficiently removed in cells by several mechanisms. © 2017 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

  13. Spin, Charge, and Bonding in Transition Metal Mono Silicides

    NARCIS (Netherlands)

    Marel, D. van der; Damascelli, A.; Schulte, K.; Menovsky, A. A.

    1997-01-01

    Published in: Physica B 244 (1998) 138-147 citations recorded in [Science Citation Index] Abstract: We review some of the relevant physical properties of the transition metal mono-silicides with the FeSi structure (CrSi, MnSi, FeSi, CoSi, NiSi, etc) and explore the relation between their structural

  14. A mono harvest of California black oak acorns

    Science.gov (United States)

    Jonathan W. Long; Ron W. Goode

    2017-01-01

    In about 1925 or 1926, Margaret Baty, a tribal member of Big Sandy Rancheria, displayed a collection of acorns from California black oak (Quercus kelloggii, wi-yap' in Mono) and an acorn cooking basket. This photograph, taken by George Holt and courtesy of the Flegal Collection of the Jesse Peter Museum at Santa Rosa Junior College,...

  15. IRIS Toxicological Review of Ethylene Glycol Mono Butyl ...

    Science.gov (United States)

    EPA has finalized the Toxicological Review of Ethylene Glycol Mono Butyl Ether: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health. N/A

  16. Mono- and binuclear complexes of low-valent zirconium

    NARCIS (Netherlands)

    Wielstra, IJtsen

    1990-01-01

    This thesis is a study on the synthesis and reactivity of low-valent zirconium. The investigation can be divided in two parts: the first describes the chemistry of mono-cyclopentadienyl Zr (II) complexes (Chapter II, III and IV), and the second describes some synthetic pathways successfully used for

  17. Convenient Regioselective mono-2-O-Sulfonation of Cyclomaltooctaose.

    Science.gov (United States)

    Teranishi, K; Tanabe, S; Hisamatsu, M; Yamada, T

    1998-01-01

    Regioselective mono-2-O-sulfonation of cyclomaltooctaose was conveniently achieved by using the combination of sulfonyl imidazole and molecular sieves in DMF. In this reaction, no 3-O- or 6-O-sulfonation products were produced. The reactions do not require strict anhydrous or basic conditions, or specific sulfonyl groups.

  18. Cost-Effective Mass Production of Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Gres, Szymon; Nielsen, Søren Andreas; Fejerskov, Morten

    2015-01-01

    No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution...

  19. Lezioni di meccanica razionale con elementi di statica grafica

    CERN Document Server

    Sbrana, Francesco

    1950-01-01

    Elementi di calcolo vettoriale ; riduzione di un sistema qualunque di vettori applicati ; trattazione analitica dei sistemi di vettori applicati ; uso dei poligni funicolari per la composizione di più vettori applicati complanari ; vettori variabili ; cinematica del punto ; studio del moto di un punto in un piano in coordinate polari ; cinematica de sistemi rigidi ; moto di un sistema rigido con un punto fisso (moto rigido sferico) ; moto relativo ; sistemi di punti in general, vincoli ; concetti e postulati fondamentali della meccanica ; unità mecchaniche, omogeneità, modelli ; equilibrio di un punto e di un sistema di punti materiali ; statica dei solidi indeformabili (sistemi rigidi) ; sistemi deformabili, travature reticolari ; equilibrio dei poligoni funicolari e delle curve funicolari ; nozioni sull'attrito ; integrazione grafica ; baricentri ; momenti d'inerzia ; calcolo grafico dei momenti statici e dei momenti d'inerzia dei sistemi piani ; dinamica del punto libero ; dinamica del punto vincolato ;...

  20. Elaborazione didattica di Learning Objects.

    Directory of Open Access Journals (Sweden)

    Luigi Guerra

    2006-01-01

    Full Text Available L’idea di un modello didattico problematico per la realizzazione di Learning Objects riprende i temi del problematicismo pedagogico e si impegna a definire un’ipotesi formativa complessa capace di valorizzare la possibile positiva compresenza integrata di strategie didattiche diverse (finanche antitetiche ma componibili in una logica appunto di matrice problematicista. Il punto di partenza del modello proposto è rappresentato dalla opportunità di definire tre tipologie fondamentali di Learning Objects, rispettivamente centrati sull’oggetto, sul processo e sul soggetto dell’apprendimento.

  1. Elementi di chimica fisica

    CERN Document Server

    Atkins, Peter W

    1994-01-01

    Elementi di chimica physica mira a presentare i concetti e le tecniche basilari della materia. I primi trovano utilizzazione in molte altre branche della chimica - la biochimica, l'ingegneria chimica, e (sempre di più) le scienze biologiche e mediche - mentre la materia in sé mette a disposizione procedimenti idonei ad esprimere idee qualitative in forma quantitativa e verificabile.

  2. Elementi di fisica teorica

    CERN Document Server

    Cini, Michele

    2006-01-01

    Le idee e le tecniche della Fisica Teorica del XX secolo (meccanica analitica, meccanica statistica, relatività e meccanica quantistica non relativistica) non sono più appannaggio esclusivo dei fisici. Ormai, specialmente con la recente introduzione di nuovi corsi di laurea, le conoscenze di base rientrano nel bagaglio culturale comune ai laureati in materie scientifiche e tecnologiche affini alla Fisica e alle sue applicazioni. Un laureato in queste materie non può non conoscere l’equazione E=mc2 e la media di Gibbs; inoltre deve avere i concetti e i metodi fondamentali della meccanica quantistica che ha cambiato la concezione del mondo ed è alla base della rivoluzione tecnologica in corso. Eppure quelle idee rimangono distanti dal comune modo di pensare e richiedono molto studio e un insegnamento ben mirato. La trattazione in questo libro, è meno formale rispetto ai tradizionali corsi di Istituzioni di Fisica Teorica. Lo scopo è comunque quello di raggiungere una reale comprensione dei concetti fisi...

  3. Pyrogen testing of lipid-based TPN using Mono Mac 6 monocyte cell line and DELFIA

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    1997-01-01

    Measurement of lipopolysaccharide (LPS) induced interleukin-6 (IL-6) secretion in Mono Mac 6 cells.......Measurement of lipopolysaccharide (LPS) induced interleukin-6 (IL-6) secretion in Mono Mac 6 cells....

  4. CONTINUOUS PRODUCTION OF THE PHARMACEUTICAL 7,8-DIHYDROXY N-DI-N-PROPYL 2-AMINOTETRALIN USING A PHENOLOXIDASE FROM CELL-CULTURES OF MUCUNA-PRURIENS

    NARCIS (Netherlands)

    PRAS, N; BATTERMAN, S; DIJKSTRA, D; HORN, AS; MALINGRE, TM

    1990-01-01

    Alginate-entrapped cells of Mucuna pruriens as well as the phenoloxidase isolated from the cell cultures, are able to ortho-hydroxylate several mono-, bi- and tri-cyclic monophenols. In this study, 7,8-dihydroxy N-di-n-propyl 2-aminotetralin, a catechol of pharmaceutical interest and difficult to

  5. Synthesis and biological activity of novel mono-indole and mono-benzofuran inhibitors of bacterial transcription initiation complex formation.

    Science.gov (United States)

    Mielczarek, Marcin; Thomas, Ruth V; Ma, Cong; Kandemir, Hakan; Yang, Xiao; Bhadbhade, Mohan; Black, David StC; Griffith, Renate; Lewis, Peter J; Kumar, Naresh

    2015-04-15

    Our ongoing research focused on targeting transcription initiation in bacteria has resulted in synthesis of several classes of mono-indole and mono-benzofuran inhibitors that targeted the essential protein-protein interaction between RNA polymerase core and σ(70)/σ(A) factors in bacteria. In this study, the reaction of indole-2-, indole-3-, indole-7- and benzofuran-2-glyoxyloyl chlorides with amines and hydrazines afforded a variety of glyoxyloylamides and glyoxyloylhydrazides. Similarly, condensation of 2- and 7-trichloroacetylindoles with amines and hydrazines delivered amides and hydrazides. The novel molecules were found to inhibit the RNA polymerase-σ(70)/σ(A) interaction as measured by ELISA, and also inhibited the growth of both Gram-positive and Gram-negative bacteria in culture. Structure-activity relationship (SAR) studies of the mono-indole and mono-benzofuran inhibitors suggested that the hydrophilic-hydrophobic balance is an important determinant of biological activity. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Filogeografia di alcune specie di mammiferi in Europa

    Directory of Open Access Journals (Sweden)

    Ettore Randi

    2003-10-01

    Full Text Available La filogeografia si occupa dello studio della distribuzione geografica delle linee genetiche che sono presenti nelle popolazioni all'interno di una specie o in gruppi di specie filogeneticamente vicine. In Europa la distribuzione geografica della diversità genetica viene interpretata nel contesto dei cambiamenti climatici del Pleistocene, assumendo che i ripetuti cicli glaciali ed interglaciali abbiano determinato profonde trasformazioni nella distribuzione delle comunità e delle singole specie. Evidenze paleoecologiche e molecolari suggeriscono che le popolazioni di specie adattate ai climi temperati siano sopravissute alle glaciazioni in aree rifugio meridionali (sia nelle regioni Mediterranee che in Europa orientale, acquisendo caratteristiche genetiche peculiari. Nel corso dei periodi interglaciali, queste popolazioni hanno ricolonizzato l'Europa centrale e settentrionale, seguendo vie di dispersione che sono ricostruibili tramite l'analisi di specifici marcatori genetici. L'analisi filogeografica indica che ogni specie ha la propria storia. Tuttavia è possibile individuare alcuni "modelli" di filogeografia dei mammiferi in Europa: il modello classico dei rifugi meridionali (esemplificato dal caso del riccio, Erinaceus europaeus; un modello caratterizzato da successive fasi di colonizzazione da aree di speciazione in Eurasia (come nel caso del camoscio, Rupicapra, un modello caratterizzato dalla dislocazione settentrionale di intere popolazioni che scompaiono completamente dalle aree rifugio (come è avvenuto in alcune specie di chirotteri e di specie di ungulati a distribuzione settentrionale. Esistono, infine, casi di apparente mancanza di struttura filogeografica, come, ad esempio, nel caso del lupo e di altre specie ad elevato potenziale di dispersione e di flusso genico. L'analisi filogeografica consente di identificare alcune popolazioni di mammiferi distribuite nelle presunte aree di rifugio, comprendenti l

  7. 21 CFR 172.824 - Sodium mono- and dimethyl naphthalene sulfonates.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Sodium mono- and dimethyl naphthalene sulfonates... FOOD FOR HUMAN CONSUMPTION Multipurpose Additives § 172.824 Sodium mono- and dimethyl naphthalene sulfonates. The food additive sodium mono- and dimethyl naphthalene sulfonates may be safely used in...

  8. 21 CFR 573.800 - Polyethylene glycol (400) mono- and dioleate.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Polyethylene glycol (400) mono- and dioleate. 573... DRINKING WATER OF ANIMALS Food Additive Listing § 573.800 Polyethylene glycol (400) mono- and dioleate. (a) The food additive polyethylene glycol (400) mono- and dioleate meets the following specifications...

  9. 77 FR 71611 - Land Acquisitions; North Fork Rancheria of Mono Indians of California

    Science.gov (United States)

    2012-12-03

    ... Bureau of Indian Affairs Land Acquisitions; North Fork Rancheria of Mono Indians of California AGENCY... trust for gaming purposes for the North Fork Rancheria of Mono Indians of California on November 26... land in trust for the North Fork Rancheria of Mono Indians of California under the authority of the...

  10. 40 CFR 721.8340 - Mono esters from 2- propenoic acid (generic).

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Mono esters from 2- propenoic acid... Specific Chemical Substances § 721.8340 Mono esters from 2- propenoic acid (generic). (a) Chemical... as mono esters from 2-propenoic acid (PMN P-01-85) is subject to reporting under this section for the...

  11. 21 CFR 573.820 - Polyoxyethylene glycol (400) mono- and dioleates.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Polyoxyethylene glycol (400) mono- and dioleates... DRINKING WATER OF ANIMALS Food Additive Listing § 573.820 Polyoxyethylene glycol (400) mono- and dioleates. The food additive polyoxyethylene glycol (400) mono- and dioleates may be safely used as an emulsifier...

  12. 40 CFR 721.5255 - 2-Naphthalenol, mono and dioctyl derivs.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 2-Naphthalenol, mono and dioctyl... Specific Chemical Substances § 721.5255 2-Naphthalenol, mono and dioctyl derivs. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 2-naphthalenol, mono and...

  13. Biosynthesis of mono-acylated mannosylerythritol lipid in an acyltransferase gene-disrupted mutant of Pseudozyma tsukubaensis.

    Science.gov (United States)

    Saika, Azusa; Utashima, Yu; Koike, Hideaki; Yamamoto, Shuhei; Kishimoto, Takahide; Fukuoka, Tokuma; Morita, Tomotake

    2018-02-01

    The basidiomycetous yeast genus Pseudozyma produce large amounts of mannosylerythritol lipids (MELs), which are biosurfactants. A few Pseudozyma strains produce mono-acylated MEL as a minor compound using excess glucose as the sole carbon source. Mono-acylated MEL shows higher hydrophilicity than di-acylated MEL and has great potential for aqueous applications. Recently, the gene cluster involved in the MEL biosynthesis pathway was identified in yeast. Here, we generated an acyltransferase (PtMAC2) deletion strain of P. tsukubaensis 1E5 with uracil auxotrophy as a selectable marker. A PtURA5-mutant with a frameshift mutation in PtURA5 was generated as a uracil auxotroph of strain 1E5 by ultraviolet irradiation on plate medium containing 5-fluoro-orotic acid (5-FOA). In the mutant, PtMAC2 was replaced with a PtURA5 cassette containing the 5' untranslated region (UTR) (2000 bp) and 3' UTR (2000 bp) of PtMAC2 by homologous recombination, yielding strain ΔPtMAC2. Based on TLC and NMR analysis, we found that ΔPtMAC2 accumulates MEL acylated at the C-2' position of the mannose moiety. These results indicate that PtMAC2p catalyzes acylation at the C-3' position of the mannose of MEL.

  14. Note di fotonica

    CERN Document Server

    Degiorgio, Vittorio

    2012-01-01

    L’invenzione del laser ha generato una vera rivoluzione nella scienza e nella tecnologia e ha dato luogo alla nascita di una nuova disciplina chiamata Fotonica. Le più importanti applicazioni della Fotonica che hanno un impatto cruciale in molti ambiti della nostra vita sono le comunicazioni in fibra ottica su cui si basa il funzionamento di Internet e del traffico telefonico su grandi distanze, i dischi ottici (CD, DVD, Blue-ray), la sensoristica ottica di tipo industriale e ambientale, la lavorazione dei materiali, l’illuminazione con i LED e la chirurgia. Questo volume ha come obiettivo quello di colmare un vuoto nel panorama italiano di testi universitari riguardanti la Fotonica. Lo scopo principale è quello di esporre in modo sintetico ma rigoroso i concetti che stanno alla base del funzionamento del laser e della propagazione della luce nella materia, e di descrivere i principali componenti e dispositivi ottici e optoelettronici, quali le fibre ottiche, gli amplificatori, i modulatori e i rivelato...

  15. Cacciatori di particelle

    CERN Document Server

    Ne'eman, Yuval

    1988-01-01

    Capostipite dei "cacciatori di particelle" fu J.J. Thomson, il quale nel 1897 scoprì la prima particella subatomica, l'elettrone. Poco dopo, negli anni tra il 1910 e il 1932, veniva rivelata la natura del nucleo atomico, grazie al lavoro di Rutherford. Partendo da queste prime storiche conquiste della fisica, gli autori introducono gradualmente il lettore nel micromondo delle particelle: dall'elettroscopio a foglie d'oro al dualismo onda-particella, all'enigma di una asimmetria destra-sinistra in natura, all'invenzione dei grandi acceleratori. Poi tra la fine degli anni cinquanta e i primi anni sessanta, l'esplosione di nuove specie particellari sembra vanificare ogni speranza di spiegazione. Lo schema di classificazione introdotto nel 1964 da Ne'eman (e, indipendentemente, da Gell-Mann), pone fine a tale confusione, consentendo una sistemazione coerente: quella che porta al concetto di quark e alle ultime conquiste, teoriche e sperimentali. Oggi, che i fisici sono divenuti più "coltivatori" che "cacciatori...

  16. Elementi di trasmissione del calore

    CERN Document Server

    Guglielmini, Giovanni

    1990-01-01

    Introduzione ; concetti fondamentali di conduzione termica ; conduzione termica in regime stazionario ; conduzione termica in regime variabile ; analisi numerica nei problemi do conduzione ; concetti fondamentali di convezione termica ; convezione forzata ; convezione naturale ; scambio termico in ebollizione e condensazione ; concetti fondamentali di radiazione termica ; scambio termico per radiazione ; scambiatori di calore ; problemi termici negli edifici.

  17. Shiatsu Di Jepang

    OpenAIRE

    Simanjuntak, Ricardo

    2015-01-01

    Shiatsu adalah sebuah kata dalam bahasa Jepang yang bila diterjemahkan secara harafiah artinya “tekanan jari”.Hal ini merupakan tekanan jari yang di berikan ke tubuh sebagai metode utama penerapan shiatsu untuk merangsang suatu respon penyembuhan.Namun,shiatsu lebih dari situ.Teknik shiatsu tidak hanya menggunakan jari,tetapi juga ibu jari,telapak tangan,lutut,lengan bawah,siku dan kaki.Lebih jauh lagi,kerena shiatsu dilakukan di lantai dan di tikar ataupun tempat tidur,shiatsu juga focus pad...

  18. Humanos salvajes y monos altruistas. Reflexiones sobre Darwin

    Directory of Open Access Journals (Sweden)

    Jorge Martinez Contreras

    2009-10-01

    Full Text Available RESUMEN   Darwin propuso en 1871 que preferiría descender de un mono que de los “salvajes”. El mono es un babuino hamadryas que, en un relato de Brehm, salva a un infante de una jauría. Los “salvajes” son los fueguinos a los que visitó en los años 1830. ¿Por qué Darwin fue tan buen observador del comportamiento animal y por qué no dudo discernir en qué consistía la sociedad de cazadores-recolectores de los cuatro grupos de Tierra del Fuego?. Esto es lo que tratamos de dilucidar en este trabajo.   Palabras clave: Darwin, fueguinos, hamadryas, altruismo, egoísmo.

  19. Mono Lake Analog Mars Sample Return Expedition for AMASE

    Science.gov (United States)

    Conrad, P. G.; Steele, A.; Younse, P.; DiCicco, M.; Morgan, A. R.; Backes, P.; Eigenbrode, J. E.; Marquardt, D.; Amundsen, H. E. F.

    2011-01-01

    We explored the performance of one robotic prototype for sample acquisition and caching of martian materials that has been developed at the Jet Propulsion Laboratory for potential use in the proposed MAX-C Mars Sample Return architecture in an environment, rich in chemical diversity with a variety of mineralogical textures. Mono Lake State Tufa Reserve in Mono County, CA possesses a variety of minerals including a variety of evaporites, volcanic glass and lava, and sand and mudstones. The lake itself is an interesting chemical system: the water is highly alkaline (pH is approximately 10) and contains concentrations of Cl, K, B, with lesser amounts of S Ca Mg, F, As, Li, I and Wand generally enriched HREEs. There are also traces of radioactive elements U, Th, Pl.

  20. KEANEKARAGAMAN REPTIL IMPOR DI YOGYAKARTA

    OpenAIRE

    Putranto, Dicky Indar

    2014-01-01

    Reptil impor banyak diminati karena memiliki variasi warna yang sangat beragam. Penelitian ini mengenai jenis reptil eksotik apa saja yang ada di Yogyakarta baik yang dipelihara maupun yang sudah terlepas atau dilepas di alam dan bagaimana pula potensi dampaknya bagi spesies reptil lokal yang ada di Yogyakarta. Penelitian ini dilakukan di wilayah Kota Yogyakarta dengan melakukan survei di pasar hewan, petshop dan pemelihara reptil. Penelitian ini telah dilaksanakan dari tang...

  1. Keanekaragaman Reptil Impor Di YOGYAKARTA

    OpenAIRE

    Putranto, Dicky Indar

    2016-01-01

    Reptil impor banyak diminati karena memiliki variasi warna yang sangat beragam. Penelitian ini mengenai jenis reptil eksotik yang ada di Yogyakarta baik yang dipelihara maupun yang sudah terlepas atau dilepas di alam dan bagaimana pula potensi dampaknya bagi spesies reptil lokal yang ada di Yogyakarta. Penelitian dilakukan di wilayah Kota Yogyakarta dengan melakukan survei di pasar hewan, petshop dan pemelihara reptil. Penelitian telah dilaksanakan dari tanggal 1 Agustus 2013 sampai 30 Novemb...

  2. EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 73, Revision 1: Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting) structurally related to primary

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 16 alicyclic primary alcohols, aldehydes, acids and related esters evaluated by the JECFA at the 59th meeting in 2002. The revision is made due to consideration of one additional...

  3. STABILITY OF AXIALLY COMPRESSED SINGLE-CELL MONO ...

    African Journals Online (AJOL)

    60. N.N. OSADEBE and J.C. EZEH. Figure 1 shows one of the cross sections of a single-cell mono symmetric thin-walled closed column under consideration. Using. Lagrange's principle, Vlasov [6] expressed the displacements in the longitudinal and transverse directions, u(x, s) and v(x, s) of a thin-walled closed structure in ...

  4. Modification and performance evaluation of a mono-valve engine

    Science.gov (United States)

    Behrens, Justin W.

    A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

  5. Gamma spectra pictures using a digital plotter. Program MONO

    International Nuclear Information System (INIS)

    Los Arcos Merino, J.M.

    1978-01-01

    The program MONO has been written for a CALCOMP-936 digital plotter operating off- -line with a UMI VAC 1106 computer, to obtain graphic representations of single gamma spectra stored on magnetic tape. It allows to plot the whole spectrum or only a part, as well as to draw a given spectrum on the same or different picture than the previous one. Ten representation scales are available and at up nine comment lines can be written in a graphic. (Author) 4 refs

  6. Il libro di fisica

    CERN Document Server

    Asimov, Isaac

    1986-01-01

    Isaac Asimov, illustre studioso e brillante divulgatore scientifico, ma anche grandissimo scrittore di science fiction, ha costruito questa volta una vera e propria «biografia delle scienze fisiche». Il presente volume, che nel mondo anglosassone è diventato una «bibbia della fisica», ci introduce, in forma semplice ma rigorosa, ai segreti dei quasar e dei buchi neri, dei quark e degli acceleratori di particelle, dell'intelligenza artificiale e delle fonti di energia, sia essa quella «sporca» sia quella «pulita». Un vero, completo manuale, ma anche un «romanzo» affascinante sia per il profano sia per l'uomo di scienza.

  7. Il Bosone di Higgs

    CERN Multimedia

    Hemmer, Sabine

    2018-01-01

    Poster di ATLAS sul bosone di Higgs indirizzato al pubblico generico, che spiega il meccanismo di Brout-Englert-Higgs e la sua importanza. Spiega anche il ruolo del Bosone di Higgs, come viene cercato, il percorso della sua scoperta e cosa viene dopo la scoperta. Disponibile anche in Francese (http://cds.cern.ch/record/1697501) e Inglese (http://cds.cern.ch/record/1697389). Non esitate a utilizzarlo nelle sedi dei vostri Istituti e negli eventi divulgativi! Il poster è in formato A0. Cliccate sull'immagine per scaricare il .pdf ad alta qualità e stamparlo dove preferite. Per qualisasi domanda o commento potete contattare atlas-outreach-coordination@cern.ch

  8. Note di fotonica

    CERN Document Server

    Degiorgio, Vittorio

    2016-01-01

    L’invenzione del laser ha generato una vera rivoluzione nella scienza e nella tecnologia e ha dato luogo alla nascita di una nuova disciplina chiamata Fotonica. Le applicazioni della Fotonica che hanno un impatto cruciale in molti ambiti della nostra vita sono le comunicazioni in fibra ottica su cui si basa il funzionamento di Internet e del traffico telefonico su grandi distanze, i dischi ottici (CD, DVD, Blu-ray), la sensoristica ottica di tipo industriale e ambientale, la lavorazione dei materiali e la chirurgia con il laser, l’illuminazione con i LED. Questa seconda edizione contiene diversi ampliamenti e modifiche al testo pubblicato nel 2012, che ha colmato un vuoto nel panorama italiano di testi universitari riguardanti la Fotonica. Dopo avere esposto in modo sintetico ma rigoroso i concetti che stanno alla base del funzionamento del laser e della propagazione della luce nella materia, sono descritti i principali componenti e dispositivi ottici e optoelettronici, quali le fibre ottiche, gli amplifi...

  9. Mafia di provincia

    Directory of Open Access Journals (Sweden)

    Giampiero Rossi

    2016-09-01

    Full Text Available Al contrario di quanto si tende a credere il “piccolo centro” di provincia potrebbe rivelarsi un luogo molto più normato rispetto alla grande città: autovelox quasi inevitabile appena al di là del cartello che indica la località, zone a traffico limitato e sosta regolamentata (con buona pace dell’illuso in trasferta dal capoluogo, orari più rigidi e marcata connotazione dei locali di ritrovo (per giovani, da aperitivo, da dopocena.... Le stesse relazioni tra le persone sono vincolate al fatto che tutti (o quasi risultano conosciuti e riconosciuti per un proprio specifico ruolo nella comunità, da quello istituzionale a quello informale. Ed è molto più difficile sottrarsi a quel ruolo per rivestirne uno diverso, anche solo temporaneamente.

  10. Appunti di meccanica relativistica

    CERN Document Server

    Cattaneo, Carlo

    1972-01-01

    Gli assiomi della fisica classica ; esame di alcuni esperimenti ottici alla luce dei principi della fisica classica ; i fondamenti generali della relatività ; conferme sperimentali della cinematica relativistica ; dinamica del punto materiale.

  11. Manuale di ottica

    CERN Document Server

    Giusfredi, Giovanni

    2015-01-01

    Questo libro costituisce un fondamento solido per la conoscenza dell’Ottica Fisica, presentando vari modi di trattare la propagazione di onde elettromagnetiche e indicando quali siano i metodi utili a specifici casi. Iniziando dall’elettromagnetismo, la riflessione, la rifrazione e la dispersione delle onde, espone argomenti quali l’Ottica Geometrica, l’Interferenza, la Diffrazione, la Coerenza, i fasci Laser, la Polarizzazione, la Cristallografia e l’Anisotropia. Tratta componenti ottici come lenti, specchi, prismi, interferometri classici, Fabry-Perot e cavità risonanti, multistrati dielettrici, filtri interferenziali e spaziali, reticoli di diffrazione, polarizzatori e lamine birifrangenti. Vi sono inoltre argomenti poco reperibili, come il metodo delle matrici 4x4 per lo studio di fronti d’onda generalmente astigmatici, i metodi numerici tramite FFT per il calcolo della diffrazione, e la Bi-anisotropia, che tratta relativisticamente l’attività ottica e gli effetti Faraday e Fresnel-Fizeau....

  12. Reconstruction of mono-vacancies in carbon nanotubes: Atomic relaxation vs. spin polarization

    International Nuclear Information System (INIS)

    Berber, S.; Oshiyama, A.

    2006-01-01

    We have investigated the reconstruction of mono-vacancies in carbon nanotubes using density functional theory (DFT) geometry optimization and electronic structure calculations, employing a numerical basis set. We considered mono-vacancies in achiral nanotubes with diameter range ∼4-9A. Contrary to previous tight-binding calculations, our results indicate that mono-vacancies could have several metastable geometries, confirming the previous plane-wave DFT results. Formation energy of mono-vacancies is 4.5-5.5eV, increasing with increasing tube diameter. Net magnetic moment decreases from ideal mono-vacancy value after reconstruction, reflecting the reduction of the number of dangling bonds. In spite of the existence of a dangling bond, ground state of mono-vacancies in semiconducting tubes have no spin polarization. Metallic carbon nanotubes show net magnetic moment for most stable structure of mono-vacancy, except for very small diameter tubes

  13. Age of the Mono Lake excursion and associated tephra

    Science.gov (United States)

    Benson, L.; Liddicoat, J.; Smoot, J.; Sarna-Wojcicki, A.; Negrini, R.; Lund, S.

    2003-01-01

    The Mono Lake excursion (MLE) is an important time marker that has been found in lake and marine sediments across much of the Northern Hemisphere. Dating of this event at its type locality, the Mono Basin of California, has yielded controversial results with the most recent effort concluding that the MLE may actually be the Laschamp excursion (Earth Planet. Sci. Lett. 197 (2002) 151). We show that a volcanic tephra (Ash #15) that occurs near the midpoint of the MLE has a date (not corrected for reservoir effect) of 28,620 ?? 300 14C yr BP (??? 32,400 GISP2 yr BP) in the Pyramid Lake Basin of Nevada. Given the location of Ash #15 and the duration of the MLE in the Mono Basin, the event occurred between 31,500 and 33,300 GISP2 yr BP, an age range consistent with the position and age of the uppermost of two paleointensity minima in the NAPIS-75 stack that has been associated with the MLE (Philos. Trans. R. Soc. London Ser. A 358 (2000) 1009). The lower paleointensity minimum in the NAPIS-75 stack is considered to be the Laschamp excursion (Philos. Trans. R. Soc. London Ser. A 358 (2000) 1009).

  14. Seasonality of cavitation and frost fatigue in Acer mono Maxim.

    Science.gov (United States)

    Zhang, Wen; Feng, Feng; Tyree, Melvin T

    2017-12-08

    Although cavitation is common in plants, it is unknown whether the cavitation resistance of xylem is seasonally constant or variable. We tested the changes in cavitation resistance of Acer mono before and after a controlled cavitation-refilling and freeze-thaw cycles for a whole year. Cavitation resistance was determined from 'vulnerability curves' showing the percent loss of conductivity versus xylem tension. Cavitation fatigue was defined as a reduction of cavitation resistance following a cavitation-refilling cycle, whereas frost fatigue was caused by a freeze-thaw cycle. A. mono developed seasonal changes in native embolisms; values were relatively high during winter but relatively low and constant throughout the growing season. Cavitation fatigue occurred and changed seasonally during the 12-month cycle; the greatest fatigue response occurred during summer and the weakest during winter, and the transitions occurred during spring and autumn. A. mono was highly resistant to frost damage during the relatively mild winter months; however, a quite different situation occurred during the growing season, as the seasonal trend of frost fatigue was strikingly similar to that of cavitation fatigue. Seasonality changes in cavitation resistance may be caused by seasonal changes in the mechanical properties of the pit membranes. © 2017 John Wiley & Sons Ltd.

  15. Citywalk Kalimas di Surabaya

    OpenAIRE

    Susanto W, Catherine

    2013-01-01

    Proyek tugas akhir ini merupakan fasilitas rekreasi yang terintegrasi dengan fasilitas retail dan kuliner. Fasilitas ini ditujukan sebagai tujuan baru masyarakat Surabaya serta mengintegrasikan fasilitas di sekitar kompleks site. Fasilitas ini didesain dengan mengutamakan wadah untuk rekreasi dan bersosialisasi masyarakat Surabaya sehingga wadah rekreasi dan bersosialisasi masyarakat Surabaya tidak hanWya terpusat di shopping mall, yang sebenarnya ada lah tempat untuk berbelanja. Pendekatan y...

  16. Stress indotto dalla guida di autoveicoli: studio di parametri psicofisiologici

    Directory of Open Access Journals (Sweden)

    R. Vivoli

    2003-05-01

    Full Text Available

    La guida di un autoveicolo, specie in condizioni di intenso traffico o di cattive condizioni meteoclimatiche, è considerata uno dei principali fattori stressanti della vita odierna. Durante la guida si possono infatti osservare significative risposte simpatoadrenergiche e cardiovascolari con la comparsa anche di episodi coronarici. Tali risposte presentano un’ampia variabilità interindividuale in quanto sono influenzate da vari fattori (stile di vita, personalità etc..

    In questa rassegna, vengono presentati i principali risultati degli studi da noi condotti sulle risposte psicofisiologiche indotte dalla guida di diversi tipi di autoveicoli. In conducenti di autobus urbani è stato registrato un sensibile aumento del tasso urinario di adrenalina durante il turno lavorativo rispetto alla stessa fascia oraria di un giorno di riposo. Tale risposta adrenergica era esaltata dall’abitudine tabagica e dall’assunzione di caffè e bevande alcoliche. In soggetti che alla guida di camion coprono lunghe distanze, i più elevati tassi urinari di catecolamine e i più alti livelli di frequenza cardiaca sono stati registrati quando la guida era particolarmente stressante per la presenza di nebbia o di intenso traffico. In soggetti che partecipano, a livello amatoriale, a manifestazioni agonistiche di velocità su pista, abbiamo osservato che durante la gara, rispetto al periodo pre-gara, l’escrezione urinaria di catecolamine aumenta in misura molto rilevante. Analogamente a quanto osservato in autisti di camion, l’attivazione del sistema adrenergico è risultata direttamente associata ai livelli di ansietà. Dall’elettrocardiogramma dinamico è emerso che durante la gara la frequenza cardiaca raggiunge un valore medio di 163.5±7.4 battiti/min. (range: 146,180 battiti/min..

    Un significativo peggioramento della percezione visiva stereoscopica, con potenziale ricaduta negativa sulla performance dei guidatori, è stato osservato in

  17. Identificazione, caratterizzazione ed industrializzazione di ceppi di Streptococcus thermophilus per la produzione di yogurt

    OpenAIRE

    D'Alonges, Sara

    2013-01-01

    Il contesto globale del comparto agro-alimentare richiede ad oggi una ricerca continua per assicurare qualità e sicurezza degli alimenti. La produzione moderna di alimenti richiede elevato grado di standardizzazione, particolarmente la produzione gli alimenti fermentati che include un processo biotecnologico in cui la componente biotica gioca un ruolo fondamentale Di qui la necessità disporre di un’ampia gamma di microrganismi atti alla conduzione del processo fermentativo in modo da im...

  18. cimitero di Praga' di Umberto Eco

    Directory of Open Access Journals (Sweden)

    Maria Grazia Cossu

    2012-12-01

    Full Text Available Examples of Cultural Anti-Semitism in Umberto Eco’s Novel Il cimitero di PragaThe article draws upon Umberto Eco’s recent novel, Il cimitero di Praga, in the consideration of the relationship between narrative fiction and the collective imagination in regards to the genesis and dispersion of The Protocols of the Elders of Zion in the second half of the nineteenth century. A dangerous and mysterious text, The Protocols evoked general clamor and persecutory backlash, as it appeared to document the existence of a Judeo-Masonic conspiracy.In the work, the author also reconstructs sources of the fictional text and traces the historical, political and editorial events surrounding it, plunging into them with a gritty and irreverent realism in a chronicle of the obsession that flowed into the madness of the Shoah.Treating the subject, which is found elsewhere in the scholar’s oeuvre, requires mention of the repertoire of prejudicial accusations against the Jews throughout history, which creates, toward the end of the book, a heated and contentious debate regarding whether such delicate and reckless statements should even be made public at all. This article questions the authorial strategy in Il cimitero di Praga, and considers the novel’s literary agenda, which can be almost interpreted as a call for vigilance against manifestations of anti-Semitism still present in today’s cultural imagination.

  19. Michael-type Reactions of 1-(X-substituted phenyl)-2-propyn-1-ones with Alicyclic Secondary Amines in MeCN and H2O: Effect of Medium on Reactivity and Transition-State Structure

    International Nuclear Information System (INIS)

    Kim, Song I; Hwang, So Jeong; Um, Ik Hwan; Park, Yoon Min

    2010-01-01

    Second-order rate constants (k N ) have been measured spectrophotometrically for Michael-type reactions of 1-(X-substituted phenyl)-2-propyn-1-ones (2a-f) with a series of alicyclic secondary amines in MeCN at 25.0 ± 0.1 .deg. C. The k N value increases as the incoming amine becomes more basic and the substituent X changes form an electron-donating group (EDG) to an electron-withdrawing group (EWG). The Brφnsted-type plots are linear with β nuc = 0.48 - 0.51. The Hammett plots for the reactions of 2a-f exhibit poor correlations but the corresponding Yukawa-Tsuno plots result in much better linear correlations with ρ = 1.57 and r = 0.46 for the reactions with piperidine while ρ = 1.72 and r = 0.39 for those with morpholine. The amines employed in this study are less reactive in MeCN than in water for reactions with substrates possessing an EDG, although they are ca. 8 pK a units more basic in the aprotic solvent. This indicates that the transition state (TS) is significantly more destabilized than the ground state (GS) in the aprotic solvent. It has been concluded that the reactions proceed through a stepwise mechanism with a partially charged TS, since such TS would be destabilized in the aprotic solvent due to the electronic repulsion between the negative-dipole end of MeCN and the negative charge of the TS. The fact that primary deuterium kinetic effect is absent supports a stepwise mechanism in which proton transfer occurs after the rate-determining step

  20. Genetic structure and hierarchical population divergence history of Acer mono var. mono in South and Northeast China.

    Directory of Open Access Journals (Sweden)

    Chunping Liu

    Full Text Available Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE, whereas it has a scattered and patchy distribution in South China (SC. In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM. Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species' evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST  = 0.073; G'ST  = 0.278 among all populations, but significantly higher in the SC group than the NE group, mirroring the species' more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study.

  1. Genetic structure and hierarchical population divergence history of Acer mono var. mono in South and Northeast China.

    Science.gov (United States)

    Liu, Chunping; Tsuda, Yoshiaki; Shen, Hailong; Hu, Lijiang; Saito, Yoko; Ide, Yuji

    2014-01-01

    Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE), whereas it has a scattered and patchy distribution in South China (SC). In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM). Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species' evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST  = 0.073; G'ST  = 0.278) among all populations, but significantly higher in the SC group than the NE group, mirroring the species' more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study.

  2. In ricordo di Vittorio Bianchi

    Directory of Open Access Journals (Sweden)

    Maurizio Cutolo

    2011-09-01

    Full Text Available Vittorio Bianchi fu Ernesto e fu Mary Sbertoli naque a Cogoleto (Genova il 17 febbraio 1919. Laureato in Medicina e Chirurgia presso l’Università di Genova nel 1943 con lode fu Allievo interno della Clinica Medica di Genova negli anni 1942 e 1943, Assistente Volontario alla Clinica Medica di Perugia, quindi della Clinica Medica di Genova negli anni seguenti dove fu nominato Assistente di ruolo per concorso nel 1950. Successivamente Assistente di ruolo alla Patologia Medica diretta dal prof. Aminta Fieschi nel periodo 1954- 1969....

  3. Uso delle tecnologie nel sostegno: il punto di vista di un gruppo di insegnanti in formazione

    Directory of Open Access Journals (Sweden)

    Caterina Bembich

    2015-09-01

    Full Text Available Nel presente lavoro sono descritti gli esiti di un’indagine esplorativa, che prende in esame il punto di vista di un gruppo di insegnanti in formazione, sull’uso delle TIC nella didattica rivolta a studenti con disabilità/Bisogni Educativi Speciali (BES. È stato proposto ai docenti un questionario, al termine di un percorso formativo laboratoriale sull’uso delle TIC, che aveva l’obiettivo di indagare tre dimensioni: (1 aspetti formativi (conoscenze di base possedute dagli insegnanti sulle tecnologie; competenze acquisite durante il percorso formativo; applicabilità delle competenze nel lavoro in classe; (2 efficacia percepita nell’utilizzo delle TIC per il raggiungimento di diversi obiettivi didattici; (3 difficoltà e aspetti di criticità rilevati nell’utilizzo delle TIC. Nell’articolo saranno descritti nel dettaglio il metodo, le aree indagate e i risultati principali ottenuti dall’indagine, proponendo una riflessione critica sulle tematiche emerse.

  4. L'ISOLA DI ARTURO DI ELSA MORANTE

    African Journals Online (AJOL)

    User

    Vi è una curiosa atmosfera di attesa negli anni '50, ed è questa temperie morale che Elsa Morante rappresenta e interpreta nell'Isola di Arturo. Nel romanzo la Morante ci dà veramente un ritratto intero di quegli anni, nel senso che dal testo sorge una attitudine complessa, contenente in sè la percezione del tempo in corso, ...

  5. Treatment of menstrual migraine; multidisciplinary or mono-disciplinary approach.

    Science.gov (United States)

    Witteveen, Hester; van den Berg, Peter; Vermeulen, Guus

    2017-12-01

    The aim of this study was to compare a multidisciplinary approach of menstrual (related) migraine, combining the neurological and gynaecological consultation, to a mono-disciplinary approach involving neurological treatment. There is a clear relationship between the menstruation cycle and the occurrence of migraine (menstrual migraine). Nowadays the treatment of menstrual (related) migraine is performed by a neurologist. A treatment with attention to hormonal treatment seems more convenient. This retrospective study was performed in a cohort using data of 88 women with menstrual (related) migraine who visited the menstrual migraine clinic between 2012 and 2014 (intervention group). The results were compared to a historical control group, which consisted of women with menstrual (related) migraine who were treated before 2012 and received a mono-disciplinary approach. In the intervention group the Headache Impact (HIT) score significantly improved (65 to 59 points). The mean headache days per month declined significantly (from 6 to 3.83 days) and these women needed less use of pain medication. In the control group the decline in HIT score was less striking (65 to 63.5 points) and the mean headache days per month increased (6 to 6,5 days). It appeared that 20 out of 27 patients in the control group required a gynaecological consultation in course of time. A multidisicplinary treatment of women with menstrual (related) migraine gives better results compared to a mono-disciplinary approach. These results should be interpreted with caution as we performed a retrospective study with a relative small control group.

  6. Intracellular Mono-ADP-Ribosylation in Signaling and Disease

    Science.gov (United States)

    Bütepage, Mareike; Eckei, Laura; Verheugd, Patricia; Lüscher, Bernhard

    2015-01-01

    A key process in the regulation of protein activities and thus cellular signaling pathways is the modification of proteins by post-translational mechanisms. Knowledge about the enzymes (writers and erasers) that attach and remove post-translational modifications, the targets that are modified and the functional consequences elicited by specific modifications, is crucial for understanding cell biological processes. Moreover detailed knowledge about these mechanisms and pathways helps to elucidate the molecular causes of various diseases and in defining potential targets for therapeutic approaches. Intracellular adenosine diphosphate (ADP)-ribosylation refers to the nicotinamide adenine dinucleotide (NAD+)-dependent modification of proteins with ADP-ribose and is catalyzed by enzymes of the ARTD (ADP-ribosyltransferase diphtheria toxin like, also known as PARP) family as well as some members of the Sirtuin family. Poly-ADP-ribosylation is relatively well understood with inhibitors being used as anti-cancer agents. However, the majority of ARTD enzymes and the ADP-ribosylating Sirtuins are restricted to catalyzing mono-ADP-ribosylation. Although writers, readers and erasers of intracellular mono-ADP-ribosylation have been identified only recently, it is becoming more and more evident that this reversible post-translational modification is capable of modulating key intracellular processes and signaling pathways. These include signal transduction mechanisms, stress pathways associated with the endoplasmic reticulum and stress granules, and chromatin-associated processes such as transcription and DNA repair. We hypothesize that mono-ADP-ribosylation controls, through these different pathways, the development of cancer and infectious diseases. PMID:26426055

  7. Gli atomi di Boltzmann

    CERN Document Server

    Lindley, David

    2002-01-01

    Ludwig Boltzmann (1844-1906) è il fisico e matematico austriaco che negli ultimi decenni dell'Ottocento e ancora ai primi del Novecento lottò contro l'opinione dominante tra gli scienziati dell'epoca per affermare la teoria atomica della materia. È noto come con Albert Einstein e fino a oggi la fisica si sia sviluppata e abbia celebrato i propri trionfi lungo le linee anticipate da Boltzmann. La controversia con Mach non riguardava soltanto l'esistenza degli atomi, ma l'intero modo di fare fisica che Boltzmann non riteneva di dover limitare allo studio di quantità misurabili, introducendo invece spiegazioni più elaborate basate su ipotesi più ampie.

  8. Konservatisme Akuntansi di Indonesia

    Directory of Open Access Journals (Sweden)

    Hans Hananto Andreas

    2017-04-01

    Dalam penyajian laporan keuangan yang berkualitas, perusahaan dihadapkan oleh pertimbangan yang salah satunya adalah penerapan konservatisme akuntansi. Penelitian ini bertujuan untuk memberikan bukti empiris pengaruh company growth, profitability, dan investment opportunity set (IOS terhadap penerapan prinsip konservatisme akuntansi. Konservatisme akuntansi dalam penelitian ini diukur menggunakan perhitungan total akrual. Total akrual adalah selisih antara laba sebelum extraordinary item ditambah dengan depresiasi dikurangi dengan arus kas operasi untuk mengetahui apakah perusahaan menggunakan konservatisme akuntansi tinggi atau rendah di dalam perusahaan. Sampel yang digunakan sebanyak 114 perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI di tahun 2012 dan 2013. Metoda pemilihan sampel yang digunakan yaitu purposive sampling. Alat analisis yang digunakan untuk pengujian adalah regresi linier berganda yang sebelumnya harus lolos uji asumsi klasik. Hasil pengujian secara parsial menunjukkan company growth, profitability dan investment opportunity set berpengaruh positif signifikan terhadap konservatisme akuntansi.

  9. High pressure structural phase transition of neodymium mono pnictides

    International Nuclear Information System (INIS)

    Pagare, Gitanjali; Ojha, P.; Sanyal, S.P.; Aynyas, Mahendra

    2007-01-01

    We have investigated theoretically the high-pressure structural phase transition of two neodymium mono NdX (X=As, Sb) using an interionic potential theory with necessary modification to include the effect of Coulomb screening by the delocalized f electrons of Nd ion. These compounds exhibits first order crystallographic phase transition from their NaCl (B 1 ) phase to body centered tetragonal (BCT) at 27 GPa and 15.3 GPa respectively. We also calculated the Nd-Nd distance as a function of pressure. (author)

  10. Mono- and bis-thiazolium salts have potent antimalarial activity.

    Science.gov (United States)

    Hamzé, Abdallah; Rubi, Eric; Arnal, Pascal; Boisbrun, Michel; Carcel, Carole; Salom-Roig, Xavier; Maynadier, Marjorie; Wein, Sharon; Vial, Henri; Calas, Michèle

    2005-05-19

    Three new series comprising 24 novel cationic choline analogues and consisting of mono- or bis (N or C-5-duplicated) thiazolium salts have been synthesized. Bis-thiazolium salts showed potent antimalarial activity (much superior to monothiazoliums). Among them, bis-thiazolium salts 12 and 13 exhibited IC(50) values of 2.25 nM and 0.65 nM, respectively, against P. falciparum in vitro. These compounds also demonstrated good in vivo activity (ED(50)

  11. Mono-Z dark matter search with the ATLAS detector

    CERN Document Server

    Basalaev, Artem; The ATLAS collaboration

    2016-01-01

    A search with ATLAS detector is presented for collider signatures of weakly interacting dark matter particles (WIMPs) leading to mono-Z signal. Events with large missing transverse momentum and two oppositely-charged electrons or muons consistent with the decay of a Z-boson were selected in analysis. The limits on the mass scale of the contact interaction as a function of the dark matter particle mass and the limits on the coupling and scalar particle mediator obtained from Run 1 ATLAS data are shown. Analysis techniques specific to Run 2 are reviewed.

  12. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl ...

    Science.gov (United States)

    EPA released the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments. EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of EGBE that will appear on the Integrated Risk Information System (IRIS) database.

  13. iOS Development using MonoTouch Cookbook

    CERN Document Server

    Tavlikos, Dimitris

    2011-01-01

    The book is written in a cookbook style, presenting examples in the style of recipes, allowing you to go directly to your topic of interest, or follow topics throughout a chapter to gain in-depth knowledge. This book is essential for C# and .NET developers with no previous experience in iOS development and Objective-C developers that want to make a transition to the benefits of MonoTouch and the C# language, for creating complete, compelling iPhone, iPod and iPad applications and deploying them to the App Store.

  14. Proposta di gestione informatizzata delle liste di attesa di una struttura ospedaliera

    Directory of Open Access Journals (Sweden)

    M. Bavuso

    2003-05-01

    Full Text Available

    Obiettivo: sviluppare un modello di gestione informatizzata delle liste di attesa, specificamente per l’assistenza ospedaliera in regime di ricovero ordinario e diurno. Questo consentirà di tastare in tempo reale il “polso” della situazione, garantendo peraltro quanto previsto dalle disposizioni legislative in materia, anche attraverso un controllo diretto della Direzione Medica di Presidio, che garantisca la complessiva gestione del registro secondo criteri di eticità e trasparenza.

    Metodi: creare un database per le liste di attesa, condivisibile nell’ambito della rete ospedaliera e accessibile tramite password, contenente i seguenti record:

     • Codice identificativo U.O.C.

     • Codice Identificativo Procedura

    • Generalità paziente

     • Data visita

     • Codice di Criticità (descrive l’urgenza del ricovero

     • Medico che ha effettuato la visita

     • Data del ricovero

     • Note Conclusioni: la partecipazione, a vari livelli di responsabilità e di operatività, di varie figure professionali, è l’elemento fondante di un percorso legato alla definizione di procedure chiare, attuabili e condivise da tutti gli attori del processo.

    L’informatizzazione del sistema potrebbe permettere una visualizzazione in tempo reale per ciascuna U.O.C. delle liste di attesa, classificando i casi secondo un criterio di urgenza del ricovero. Allo stesso tempo la Direzione Medica avrebbe costantemente sotto controllo le liste di attesa, vigilando sull’osservanza degli obblighi di trasparenza ed eticità sanciti dalle disposizioni legislative. L’accesso ai dati limitato al solo personale medico, ottenuto attraverso la gestione informatica protetta, garantirebbe infine il rispetto della privacy.

  15. Sull'"Eneide" di Dryden

    OpenAIRE

    Manca, Mario

    1990-01-01

    In 'Dryden and The Art of Translation' William Frost afferma che le traduzioni costituiscono due terzi della produzione letteraria di John Dryden. Fra le traduzioni in Inglese di Dryden da Omero, Teocrito, Lucrezio, Virgilio, Orazio, Ovidio, Giovenale, Persio, Boccaccio quella dell"Eneide' di Virgilio del 1697 è certamente per noi la più interessante. Secondo Pope essa costituisce "the most noble and spirited translation in any language", così come per Earl Miner questa fatica di Dryden r...

  16. Sospensione di potestà

    Directory of Open Access Journals (Sweden)

    Maria Fausta Maternini

    2011-03-01

    Full Text Available La voce è destinata alla pubblicazione, in lingua spagnola, nel Diccionario general de Derecho canónico edito dall’Instituto Martìn de Azpilcueta, Universidad de Navarra. SOMMARIO: 1. Il concetto di potestà nella Chiesa – 2. La sospensione di potestà quale atto amministrativo - 3. … in relazione al munus santificandi - 4. … in relazione alla potestà di magistero - 5 … in relazione alla potestà di governo.

  17. Breve Manuale di Geografia Umana

    NARCIS (Netherlands)

    Minca, C.; Colombino, A.

    2012-01-01

    Il percorso per andare al lavoro, la scelta sul dove trascorrere le prossime vacanze, le nostre opinioni sulla politica estera, le nostre preoccupazioni per la crisi economica, le nostre affermazioni di identità, il nostro desiderio di fuga dal quotidiano, perfino la scelta di acquistare una casa in

  18. I problemi di matematica della Scuola Normale Superiore di Pisa

    CERN Document Server

    Profeti, Alessandro

    1998-01-01

    Nasce come aggiornamento del volume precedente ("I problemi di Matematica della Scuola Normale", 1984) e raccoglie gli esercizi di matematica assegnati all'esame di ammissione alla Scuola Normale Superiore di Pisa dal 1985 al 1997, con la loro risoluzione. Per rendere più efficace lo scopo didattico viene anche presentata una scelta di problemi relativi al periodo precedente (1905-1984). Il libro si rivolge a studenti e docenti della Scuola Secondaria, e si chiude con un Glossario in cui vengono richiamati i termini usati.

  19. Reinvestigating 2,5-di(pyridin-2-yl)pyrazine ruthenium complexes : Selective deuteration and Raman spectroscopy as tools to probe ground and excited-state electronic structure in homo- and heterobimetallic complexes

    NARCIS (Netherlands)

    Schulz, M.; Hirschmann, J.; Draksharapu, A.; Singh Bindra, G.; Soman, S.; Paul, A.; Groarke, R.; T. Pryce, M.; Rau, S.; R. Browne, W.; Vos, J.

    2011-01-01

    The mono- (1) and dinuclear (2) ruthenium(II) bis(2,2'-bipyridine) complexes of 2,5-di(pyridin-2-yl)pyrazine (2,5-dpp), for which the UV/Vis absorption and emission as well as electrochemical properties have been described earlier, are reinvestigated here by resonance, surface enhanced and transient

  20. A macrodomain-linked immunosorbent assay (MLISA) for mono-ADP-ribosyltransferases.

    Science.gov (United States)

    Chen, Jingwen; Lam, Albert T; Zhang, Yong

    2018-02-15

    ADP-ribosyltransferases (ARTs) catalyze reversible additions of mono- and poly-ADP-ribose onto diverse types of proteins by using nicotinamide adenine dinucleotide (NAD + ) as a cosubstrate. In the human ART superfamily, 14 out of 20 members are shown to catalyze endogenous protein mono-ADP-ribosylation and play important roles in regulating various physiological and pathophysiological processes. Identification of new modulators of mono-ARTs can thus potentially lead to discovery of novel therapeutics. In this study, we developed a macrodomain-linked immunosorbent assay (MLISA) for characterizing mono-ARTs. Recombinant macrodomain 2 from poly-ADP-ribose polymerase 14 (PARP14) was generated with a C-terminal human influenza hemagglutinin (HA) tag for detecting mono-ADP-ribosylated proteins. Coupled with an anti-HA secondary antibody, the generated HA-tagged macrodomain 2 reveals high specificity for mono-ADP-ribosylation catalyzed by distinct mono-ARTs. Kinetic parameters of PARP15-catalyzed automodification were determined by MLISA and are in good agreement with previous studies. Eight commonly used chemical tools for PARPs were examined by MLISA with PARP15 and PARP14 in 96-well plates and exhibited moderate inhibitory activities for PARP15, consistent with published reports. These results demonstrate that MLISA provides a new and convenient method for quantitative characterization of mono-ART enzymes and may allow identification of potent mono-ART inhibitors in a high-throughput-compatible manner. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Effect of mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells

    International Nuclear Information System (INIS)

    Reinsberg, Jochen; Wegener-Toper, Petra; Ven, Katrin van der; Ven, Hans van der; Klingmueller, Dietrich

    2009-01-01

    The phthalate ester mono-(2-ethylhexyl) phthalate (MEHP) is the active metabolite of di-(2-ethylhexyl) phthalate, a high-production-volume chemical used as a plasticizer and solvent in numerous consumer products. MEHP has been demonstrated to be a reproductive toxicant in rodents decreasing estradiol and progesterone production in preovulatory granulosa cells. In the present study, we examined the effect of MEHP on steroid production of human granulosa-lutein (GL) cells. Human GL cells collected from women undergoing in vitro fertilization were cultured in medium containing FSH, hCG and 8-Br-cAMP, respectively, together with various concentrations of MEHP (0-500 μmol L -1 ). After incubation for 48 h estradiol and progesterone were assayed in the spent culture medium. Furthermore, aromatase activity and mRNA levels of GL cells were determined. Basal as well as FSH-, hCG- and 8-Br-cAMP-stimulated estradiol production of GL cells was suppressed by MEHP in a dose-dependent manner (IC 50 = 105 μmol L -1 , 138 μmol L -1 , 49 μmol L -1 and 78 μmol L -1 ). Furthermore aromatase activity and mRNA levels were reduced in GL cells cultured with MEHP. In contrast, MEHP did not alter the production of progesterone up to a concentration of 167 μmol L -1 . The present data indicate that MEHP is a specific inhibitor of estradiol production in human GL cells with a post-cAMP site of action. The inhibition of estradiol production obviously results from a reduction of aromatase activity on the transcript level. As the in vitro effective doses of MEHP are within the range of real environmental exposure levels an inhibitory effect on estrogen production in vivo seems to be possible.

  2. Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl phthalate (MEHP.

    Directory of Open Access Journals (Sweden)

    Wenhui Zhai

    Full Text Available Phthalates are extensively used as plasticizers in a variety of daily-life products, resulting in widespread distribution in aquatic environments. However, limited information is available on the endocrine disrupting effects of phthalates in aquatic organisms. The aim of the present study was to examine whether exposure to mono-(2-ethylhexyl phthalate (MEHP, the hydrolytic metabolite of di-(2-ethylhexyl phthalate (DEHP disrupts thyroid endocrine system in fish. In this study, zebrafish (Danio rerio embryos were exposed to different concentrations of MEHP (1.6, 8, 40, and 200 μg/L from 2 h post-fertilization (hpf to 168 hpf. The whole-body content of thyroid hormone and transcription of genes involved in the hypothalamic-pituitary-thyroid (HPT axis were examined. Treatment with MEHP significantly decreased whole-body T4 contents and increased whole-body T3 contents, indicating thyroid endocrine disruption. The upregulation of genes related to thyroid hormone metabolism (Dio2 and UGT1ab might be responsible for decreased T4 contents. Elevated gene transcription of Dio1 was also observed in this study, which might assist to degrade increased T3 contents. Exposure to MEHP also significantly induced transcription of genes involved in thyroid development (Nkx2.1 and Pax8 and thyroid hormone synthesis (TSHβ, NIS and TG. However, the genes encoding proteins involved in TH transport (transthyretin, TTR was transcriptionally significantly down-regulated after exposure to MEHP. Overall, these results demonstrate that acute exposure to MEHP alters whole-body contents of thyroid hormones in zebrafish embryos/larvae and changes the transcription of genes involved in the HPT axis, thus exerting thyroid endocrine toxicity.

  3. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Tetz, Lauren M., E-mail: ltetz@umich.edu [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States); Cheng, Adrienne A.; Korte, Cassandra S. [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States); Giese, Roger W.; Wang, Poguang [Department of Pharmaceutical Sciences, Northeastern University, 360 Huntingon Ave, Boston, MA 02115 (United States); Harris, Craig; Meeker, John D.; Loch-Caruso, Rita [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States)

    2013-04-01

    Di-2-ethylhexyl phthalate (DEHP) is an environmental contaminant commonly used as a plasticizer in polyvinyl chloride products. Exposure to DEHP has been linked to adverse pregnancy outcomes in humans including preterm birth, low birth-weight, and pregnancy loss. Although oxidative stress is linked to the pathology of adverse pregnancy outcomes, effects of DEHP metabolites, including the active metabolite, mono-2-ethylhexyl phthalate (MEHP), on oxidative stress responses in placental cells have not been previously evaluated. The objective of the current study is to identify MEHP-stimulated oxidative stress responses in human placental cells. We treated a human placental cell line, HTR-8/SVneo, with MEHP and then measured reactive oxygen species (ROS) generation using the dichlorofluorescein assay, oxidized thymine with mass-spectrometry, redox-sensitive gene expression with qRT-PCR, and apoptosis using a luminescence assay for caspase 3/7 activity. Treatment of HTR-8 cells with 180 μM MEHP increased ROS generation, oxidative DNA damage, and caspase 3/7 activity, and resulted in differential expression of redox-sensitive genes. Notably, 90 and 180 μM MEHP significantly induced mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS2), an enzyme important for synthesis of prostaglandins implicated in initiation of labor. The results from the present study are the first to demonstrate that MEHP stimulates oxidative stress responses in placental cells. Furthermore, the MEHP concentrations used were within an order of magnitude of the highest concentrations measured previously in human umbilical cord or maternal serum. The findings from the current study warrant future mechanistic studies of oxidative stress, apoptosis, and prostaglandins as molecular mediators of DEHP/MEHP-associated adverse pregnancy outcomes. - Highlights: ► MEHP increased reactive oxygen species, oxidative DNA damage, and caspase activity. ► MEHP induced expression of PTGS2, a gene

  4. Steroid Derived Mesoionic Gold and Silver Mono- and Polymetallic Carbenes.

    Science.gov (United States)

    Frutos, María; de la Torre, María C; Sierra, Miguel A

    2015-12-07

    A two-step synthesis of gold mesoionic carbene complexes containing estrone moieties has been developed. The method uses the methylation of the triazole nucleus, followed by the treatment of the triazolium salt with Ag2O and transmetalation with [AuCl(SMe2)]. Mono-, bi-, tri-, and tetrametallic gold complexes can be obtained depending on the structure of the starting triazolium salts. Tetrametallic gold carbene embedded in a macrocylic stereoidal cavity containing four estrone nuclei has been also prepared. Additionally, the mono- and bimetallic silver carbene complexes containing triazole-steroid ligands have been isolated and characterized. These complexes resulted to be stable and have been characterized by spectroscopic and HRMS techniques. The gold and silver complexes having triazole-steroid ligands are unprecedented in the literature and the method reported here to access to these compounds is easy and efficient. Preliminary results regarding the catalytic activity of some of the gold-carbenes prepared in the insertion of diazoalkanes into alcohols are presented.

  5. DiSC-OPAL

    DEFF Research Database (Denmark)

    Kemal, Mohammed Seifu; Pedersen, Rasmus; Iov, Florin

    2017-01-01

    of such systems. The simulation tool should be able to model Electrical Grid and flexible assets with different time scales and resolution levels fulfilling specific functionalities. In this paper DiSC-OPAL, an OPAL-RT compatible toolbox library for modelling of assets is presented. The library is suitable...

  6. I "limiti" del reato di associazione di tipo mafioso di fronte alle "mafie in trasferta"

    Directory of Open Access Journals (Sweden)

    Alain Maria Dell’Osso

    2016-12-01

    Full Text Available Nelle regioni dell’Italia settentrionale si assiste da tempo all’emersione di cellule criminali, anche embrionali, legate e affiliate alle mafie storiche e, in specie, alla ‘ndrangheta: nei relativi procedimenti penali si è posta la questione della configurabilità, per ciascuna di esse, di un’autonoma associazione di tipo mafioso, che deriverebbe i caratteri di mafiosità dall’associazione madre. Il saggio richiama l’attenzione sull’esigenza di una puntuale verifica dei requisiti di fattispecie del reato previsto dall’art. 416-bis c.p. in relazione alla singola associazione, circostanza che complica la possibilità di ravvisare, di volta in volta, un’associazione autonomamente rilevante. Parole chiave: associazione di tipo mafioso; nuove mafie; ‘ndrangheta; metodo mafioso; locali. Recently, in Northern Italy, came to light many small criminal groups affiliated to the huge criminal organization known as ‘Ndrangheta. This organization certainly represents one of the most important form of Mafia. The essay aims to clarify if it is correct to consider even the single small group as “mafioso”. Such a label has extremely relevant consequences: in particular, it allows to prosecute the group as an “associazione di tipo mafioso” under section 416-bis of the Italian Penal Code. Keywords: Organized crime; ‘ndrangheta; Characteristics of mafia; elements of the crime of “associazione di tipo mafioso”; mafia local cells.

  7. 40 CFR 721.1729 - Boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

    Science.gov (United States)

    2010-07-01

    ... polyethylene glycol mono-Bu ether and polyethylene glycol mono Me ether. 721.1729 Section 721.1729 Protection... acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol mono Me ether... identified as boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

  8. Il concetto di Natura nella filosofia di Denis Diderot

    Directory of Open Access Journals (Sweden)

    Francesco Consiglio

    2014-03-01

    Full Text Available L’immagine della Natura che emerge dalla lettura delle opere di Diderot, è quella di una sorta di organismo in cui tutto risulta legato da una rete di forze inquadrate in un ordine omogeneo e dinamico. Le leggi di quest’ordine sono riscontrabili in tutti gli eventi naturali ed ogni fenomeno non è mai frutto del caso, ma ordinato deterministicamente. Allo spinozismo di quest’ordine geometrico si coniuga un atomismo di matrice epicurea, speci camente nella versione lucreziana del De Rerum Natura: gli atomi che costituiscono la materia si combinano da sempre e all’in nito in un continuo divenire di forme normate da leggi intrinseche, e gli individui nascono dal cozzare e dall’ammassarsi di questi atomi. Non esiste uno stadio culmine di questa “evoluzione”, piuttosto esistono in nite varianti, nel tempo e nello spazio, di un unico modello prototipico che, secondo Diderot, evolve in una specie o in un'altra in maniera totalmente a- nalistica, sebbene assolutamente determinis- tica. La regolarità dell’ordine (per no nell’apparente caos di un turbine di pol- vere e il continuo farsi e rifarsi delle forme si connettono al principio di conti- nuità della natura: la natura non fa salti, tutto è connesso come in una ragnatela e la materia continua muta la sua disposizione in grumi di atomi che, secondo il principio dell’epigenesi, giungono a formare gli individui. Le opere in cui Diderot elabora in maniera più organica e precisa la sua concezione della natura sono particolarmente due: L’interpretazione della natura (1753 e Il sogno di d’Alembert (1769. In mezzo a queste stanno gli scritti sui Sa- lons, tra i quali è particolarmente saliente, per il discorso sulla natura, quello del 1767, in cui, con la Promenade Vernet, molti di questi temi vengono a rontati o ripresi nel pittoricismo della narrazione, attraverso limpide metafore. Natura e arte, in Diderot, sono strettamente connesse. La seconda imita la prima, ma non tenta

  9. Integrazione rigorosa di dati provenienti da fonti di acquisizione differenti

    Directory of Open Access Journals (Sweden)

    Leandro Bornaz

    2011-04-01

    Full Text Available La geomatica mette oggi a disposizione di esperti di diverse discipline un’ampia gamma di strumenti e tecniche che vengono utilizzate estensivamente come sostegno per l’acquisizione, la contestualizzazione e la georeferenziazione di informazioni molto diversificate come ad esempio dati georadar, geosismici, interferometrici, provenienti da strumenti di misura spesso utilizzati in diversi ambiti e con sistemi di riferimento differenti, talvolta non direttamente compatibili tra loro. Questa problematica, spesso trascurata utilizzando un approccio di tipo classico, è stata affrontata e risolta in modo rigoroso dagli autori permettendo così l’integrazione corretta di dati di differente natura e provenienza.Integration of data acquired from different sourcesGeomatics today offers to experts from different disciplines a wide range of tools and techniques, which are used extensively as technical support for the acquisition, context and geo-refer-encing data coming from different investigations: geo radar, interpherometry, geophysics analysis. Each technology gener-ally provide data with different reference systems, often not di-rectly compatible each other. This problem, often overlooked by using a classical approach, has been resolved in a rigorous way by the authors thus allowing proper integration of data of different nature.

  10. Metodologia di analisi del ciclo di vita di una cella a carbonati fusi

    OpenAIRE

    Di Giorgio, Ilaria

    2006-01-01

    In attuazione del protocollo di Kyoto, e sulla base delle decisione assunta successivamente dall'Unione Europea, l'Italia dovrà ridurre, entro il 2008-2012, le proprie emissioni di CO2 e degli altri gas serra nella misura del 6,5% rispetto ai valori del 1990 (555 milioni di tonnellate di CO2 equivalenti). Si è valutato che le emissioni dell’Italia hanno una traiettoria crescente che renderebbero oggettivamente difficile, con le sole risorse interne, il rispetto degli impegni di riduzione a...

  11. Dynamics of biogeochemical sulfur cycling in Mono Lake

    Science.gov (United States)

    Phillips, A. A.; Fairbanks, D.; Wells, M.; Fullerton, K. M.; Bao, R.; Johnson, H.; Speth, D. R.; Stamps, B. W.; Miller, L.; Sessions, A. L.

    2017-12-01

    Mono Lake, California is a closed-basin soda lake (pH 9.8) with high sulfate (120mM), and is an ideal natural laboratory for studying microbial sulfur cycling. Mono Lake is typically thermally stratified in summer while mixing completely in winter. However, large snowmelt inputs may induce salinity stratification that persists for up to five years, causing meromixis. During the California drought of 2014-16, the lake has mixed thoroughly each winter, but the abundant 2017 snowmelt may usher in a multi-year stratification. This natural experiment provides an opportunity to investigate the temporal relationship between microbial sulfur cycling and lake biogeochemistry. We analyzed water samples from five depths at two stations in May of 2017, before the onset of meromixis. Water column sulfate isotope values were generally constant with depth, centering at a δ34SVCDT of 17.39 ± 0.06‰. Organic sulfur isotopes were consistently lighter than lake sulfate, with a δ34SVCDT of 15.59 ± 0.56‰. This significant offset between organic and inorganic sulfur contradicts the minimal isotope effect associated with sulfate assimilation. Sediment push core organic values were further depleted, ranging between δ34SVCDT of -8.94‰ and +0.23‰, implying rapid turnover of Mono Lake sulfur pools. Both lipid biomarkers and 16S rRNA gene amplicons identify Picocystis salinarum, a unicellular green alga, as the dominant member of the microbial community. However, bacterial biomarkers and 16S rRNA genes point to microbes capable of sulfur cycling. We found that dsrA increased with depth (R2 = 0.9008, p 1 year of stratification. We saw no evidence in May of 2017 of sulfate reducing bacteria across the oxycline. Additionally, no sulfide was detectable in lake bottom waters despite oxygen below 6.25 µM. Preliminary results suggest a dynamic interplay between sulfide oxidation, sulfate reduction, and the onset of lake stratification. Additional data from September 2017 sampling will

  12. Mono- and combined antimicrobial agents efficiency in experimental wound infection

    Directory of Open Access Journals (Sweden)

    Наталія Ігорівна Філімонова

    2015-10-01

    Full Text Available Modern problems of antibiotic therapy are shown by wide range of side effects, both on organism and microbiological levels: the spread of allergies, toxic for organ systems reactions, dysbiosis development, and resistant pathogens formation and dissemination. Therefore the necessity of search for new effective drugs with significant antimicrobial activity applied for the wounds treatment arises. Development of combined remedies on the background of different origin antimicrobial agents’ derivatives is one of the fight directions against infectious diseases in the skin pathology. Recently among the existing antimicrobial agents one should focus on antiseptic drugs, due to degenerative and dysfunctional effect on microbial cell.Aim of research. The comparison of mono- and combined antimicrobial agents chemotherapeutic efficiency in the treatment of localized purulent infection under experimental conditions.Metods. The study of chemotherapeutic efficiency was carried out on the model of localized purulent Staphylococcus infection on albino mice weighting 14 – 16 g. S.aureus ATCC 25923 strains were used as infectious agents. The contamination was performed subcutaneously to the right side of mice’s skin after depilation. The animals were randomly divided into 4 groups: the 1st group – infected mice without treatment (control; the 2nd group – infected mice treated with a ciprofloxacin; the 3rd group – infected mice treated with a Ciprofloxacin and Decamethoxin combination; the 4th group – infected mice treated with a combined drug on the base of mutual prodrugs (Hexamethylenetetramine and Phenyl salicylate.Results. The efficiency of mono- and combined antimicrobial agents under experimental Staphylococcus wound infection conditions was studied. It was found that localized purulent staph center was formed more slowly in comparison with control and mono preparation use (2nd group of animals. The average index of skin lesions in comparison

  13. Behavioral ecology of American Pikas (Ochotona princeps) at Mono Craters, California: living on the edge

    Science.gov (United States)

    Andrew T. Smith; John D. Nagy; Connie Millar

    2016-01-01

    The behavioral ecology of the American pika (Ochotona princeps) was investigated at a relatively hot south-facing, low-elevation site in the Mono Craters, California, a habitat quite different from the upper montane regions more typically inhabited by this species and where most prior investigations have been conducted. Mono Craters pikas exhibited...

  14. Study of half-sandwich mono and dinuclear complexes of platinum ...

    Indian Academy of Sciences (India)

    N-donor ligands; mono and binuclear complexes; ruthenium; rhodium; iridium. 1. Introduction. Mono and binuclear complexes of platinum group metals containing heterocyclic nitrogen based ligands have received considerable attention owing to their catalytic activities1–7 as well as in the development of new biologically ...

  15. Magnetic and gravity studies of Mono Lake, east-central, California

    Science.gov (United States)

    Athens, Noah D.; Ponce, David A.; Jayko, Angela S.; Miller, Matt; McEvoy, Bobby; Marcaida, Mae; Mangan, Margaret T.; Wilkinson, Stuart K.; McClain, James S.; Chuchel, Bruce A.; Denton, Kevin M.

    2014-01-01

    From August 26 to September 5, 2011, the U.S. Geological Survey (USGS) collected more than 600 line-kilometers of shipborne magnetic data on Mono Lake, 20 line-kilometers of ground magnetic data on Paoha Island, 50 gravity stations on Paoha and Negit Islands, and 28 rock samples on Paoha and Negit Islands, in east-central California. Magnetic and gravity investigations were undertaken in Mono Lake to study regional crustal structures and to aid in understanding the geologic framework, in particular regarding potential geothermal resources and volcanic hazards throughout Mono Basin. Furthermore, shipborne magnetic data illuminate local structures in the upper crust beneath Mono Lake where geologic exposure is absent. Magnetic and gravity methods, which sense contrasting physical properties of the subsurface, are ideal for studying Mono Lake. Exposed rock units surrounding Mono Lake consist mainly of Quaternary alluvium, lacustrine sediment, aeolian deposits, basalt, and Paleozoic granitic and metasedimentary rocks (Bailey, 1989). At Black Point, on the northwest shore of Mono Lake, there is a mafic cinder cone that was produced by a subaqueous eruption around 13.3 ka. Within Mono Lake there are several small dacite cinder cones and flows, forming Negit Island and part of Paoha Island, which also host deposits of Quaternary lacustrine sediments. The typical density and magnetic properties of young volcanic rocks contrast with those of the lacustrine sediment, enabling us to map their subsurface extent.

  16. Mono(NCN-pincer palladium)-metalloporphyrin catalysts: evidence for supramolecular bimetallic catalysis

    NARCIS (Netherlands)

    Suijkerbuijk, B.M.J.M.; Schamhart, D. J.; Kooijman, H.; Spek, A.L.; van Koten, G.; Klein Gebbink, R.J.M.

    2010-01-01

    The synthesis and catalytic properties of ditopic mono-pincer-mono-porphyrin complexes were investigated. The statistical Adler condensation reaction of 3,5-bis(methoxymethyl)-4-bromo-benzaldehyde, p-tolylaldehyde, and pyrrole, furnished an AB3-type tetraphenylporphyrin, containing three

  17. Il crowdfunding finalizzato al co-finanziamento di progetti di valorizzazione di complessi di elevato valore storico architettonico: il caso di “Torino Esposizioni”

    Directory of Open Access Journals (Sweden)

    Paola Marinò

    2015-12-01

    Full Text Available L’articolo affronta il tema del finanziamento degli interventi di restauro e riuso delle grandi architetture del ‘900, in un momento storico in cui le risorse finanziarie pubbliche sono sempre più scarse e difficili da reperire. La ricerca affronta la possibilità di ricorrere al crowdfunding attraverso il caso studio del progetto di “Torino Esposizioni”, un’architettura del ‘900, parzialmente utilizzata, in stato di degrado, nonostante sia riconosciuta dalla critica internazionale come un’opera di eccezionale valore. A partire dal Master Plan, messo a punto dal Politecnico di Torino in collaborazione con la Città di Torino, è stata simulata l’applicabilità del crowdfunding attraverso un’indagine che valuta la disponibilità a contribuire da parte dei potenziali fruitori del complesso di “Torino Esposizioni” e, quindi, a comprendere l’interesse dei cittadini nei confronti del valore storico del complesso di “Torino Esposizioni” e del progetto di riuso che dovrebbe valorizzarlo. Gli esiti della ricerca, nell’evidenziare un’inattesa scarsa disponibilità a contribuire al finanziamento collettivo del progetto, hanno messo in evidenza, non solo la scarsa conoscenza del crowdfunding come strumento di finanziamento, ma anche la scarsa consapevolezza del valore storico architettonico del patrimonio moderno della città di Torino, di cui “Torino Esposizioni” rappresenta un esempio eccezionale, seppur non l’unico.

  18. Aryl hydrocarbon mono-oxygenase activity in human lymphocytes

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, G.D.; Schuresko, D.D.

    1981-06-01

    Aryl hydrocarbon mono-oxygenase (AHM), an enzyme of key importance in metabolism of xenobiotic chemicals such as polynuclear aromatic hydrocarbons (PNA), is present in human lymphocytes. Studies investing the relation of activity of AHM in human lymphocytes to parameters such as disease state, PNA exposure, in vitro mitogen stimulation, etc. have been summarized in this report. Some studies have demonstrated increased AHM activity in lymphocytes from cigarette smokers (compared to nonsmokers), and in lung cancer patients when compared to appropriate control groups. These observations are confused by extreme variability in human lymphocyte AHM activities, such variability arising from factors such as genetic variation in AHM activity, variation in in vitro culture conditions which affect AHM activity, and the problematical relationship of common AHM assays to actual PNA metabolism taking place in lymphocytes. If some of the foregoing problems can be adequately addressed, lymphocyte AHM activity could hold the promise of being a useful biomarker system for human PNA exposure.

  19. Mechanically flexible optically transparent porous mono-crystalline silicon substrate

    KAUST Repository

    Rojas, Jhonathan Prieto

    2012-01-01

    For the first time, we present a simple process to fabricate a thin (≥5μm), mechanically flexible, optically transparent, porous mono-crystalline silicon substrate. Relying only on reactive ion etching steps, we are able to controllably peel off a thin layer of the original substrate. This scheme is cost favorable as it uses a low-cost silicon <100> wafer and furthermore it has the potential for recycling the remaining part of the wafer that otherwise would be lost and wasted during conventional back-grinding process. Due to its porosity, it shows see-through transparency and potential for flexible membrane applications, neural probing and such. Our process can offer flexible, transparent silicon from post high-thermal budget processed device wafer to retain the high performance electronics on flexible substrates. © 2012 IEEE.

  20. Mono-jet signatures of gluphilic scalar dark matter

    Directory of Open Access Journals (Sweden)

    Rohini M. Godbole

    2017-09-01

    Full Text Available A gluphilic scalar dark matter (GSDM model has recently been proposed as an interesting vision for WIMP dark matter communicating dominantly with the Standard Model via gluons. We discuss the collider signature of a hard jet recoiling against missing momentum (“mono-jet” in such a construction, whose leading contribution is at one-loop. We compare the full one-loop computation with an effective field theory (EFT treatment, and find (as expected that EFT does not accurately describe regions of parameter space where mass of the colored mediator particles are comparable to the experimental cuts on the missing energy. We determine bounds (for several choices of SU(3 representation of the mediator from the s=8 TeV data, and show the expected reach of the s=13 TeV LHC and a future 100 TeV pp collider to constrain or discover GSDM models.

  1. Fatigue Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

    1991-01-01

    In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...... through linear-elastic fracture mechanics (LEFM). In determining the cumulative fatigue damage, Palmgren-Miner's rule is applied. Element reliability, as well as systems reliability, is estimated using first-order reliability methods (FORM). The sensitivity of the systems reliability to various parameters...... is investigated. The systems reliability index, estimated by using the fatigue elements with the fatigue strength expressed through SN relations, is found to be smaller than the systems reliability index estimated by using LEFM. It is shown that the systems reliability index is very sensitive to variations...

  2. Il problema della costruzione di senso nel Trattato di Sociologia Generale di Vilfredo Pareto

    Directory of Open Access Journals (Sweden)

    Andrea Millefiorini

    2017-08-01

    Full Text Available Pareto ci spiega come i residui siano al centro del complesso ordine sociale che viene a costituirsi dalla combinazione tra questi, gli interessi, l’eterogeneità della società e le derivazioni. Ai fini della costruzione di senso, vi è un genere di residui, quello definito «bisogno di sviluppi logici», il quale comprende «la maggior parte dei residui che determinano le derivazioni» . Sono poi queste ultime che, venendo diciamo così a “vivere di vita propria”, perimetrano, definiscono, determinano, conferiscono i significati individuali e collettivi sui quali l’interazione quotidiana tra gli uomini fonda la trama principale delle proprie routines, delle proprie pratiche, delle proprie condotte all’interno di ambiti di convivenza, di istituzioni, di comunità nazionali. Vi è stato chi, come Norberto Bobbio, ha tratto da questo indubbio assetto concettuale nella teoria sociologica paretiana, conseguenze e deduzioni che ci restituiscono il pensiero di Pareto come una versione socio-psicologica della teoria marxista della “falsa coscienza”. In sostanza, scrive Bobbio, «alla concezione storicistica delle ideologie propria di Marx, Pareto contrappone una concezione naturalistica dell’uomo come animale ideologico». Tuttavia bisogna intendersi. È certamente vero che le ideologie del Novecento possono essere spiegate seguendo l’approccio paretiano, ma la sua sociologia non si risolve e non si esaurisce in una semplice teoria delle ideologie. Essa è un qualcosa di ben più ampio e ben più complesso, che abbraccia tutto l’arco storico delle civiltà umane, e che quindi si pone come uno dei tentativi più ambiziosi, sino ad oggi concepiti dalle scienze sociali, di spiegare quel complicatissimo processo sociale che va sotto il nome di “costruzione di senso”.

  3. Prospettive della reazione di idroformilazione nella sintesi di composti biologicamente attivi

    OpenAIRE

    Marchetti, Mauro

    2000-01-01

    Il nostro gruppo sta conducendo uno studio su complessi di rodio con una nuova classe di leganti idrosolubili di origine proteica, tali complessi impiegati nell’idroformilazione bifasica in solvente acquoso di diversi substrati hanno fornito buoni risultati.

  4. Penanganan Cyber Crime di Sektor Perbankan di Indonesia

    OpenAIRE

    Putra, Prima Agusdani

    2011-01-01

    Di dalam dunia perbankan perkembangan cyber crime cukup mengejutkan dengan terjadi beberapa kasus yang merugikan pihak perbankan seperti; kasus pembobolan BNI New York oleh mantan karyawannya sendiri, mutasi kredit fiktif melalui komputer di BDN Cabang Bintaro Jaya, pencurian dana di Bank Danamon Pusat. Sementara itu sejumlah nasabah pemegang credit card juga mengeluh, karena nomor kartu kreditnya telah dipakai pihak lain untuk melakukan transaksi e-commerce sehingga menimbu...

  5. Signos de Wabi Sabi, Mono no Aware y Yügen en el Land Art europeo de la década de los setenta. Los paseos de Hamish Fulton y Richard Long como ejemplo paradigmático.

    OpenAIRE

    ANDRÉS ALZOLA, SONIA

    2013-01-01

    En este estudio analizamos las analogías estéticas y filosóficas entre los tres términos orientales principales del medievo japonés: mono no aware, wabi sabi y y¿gen y el `arte de la tierra¿ surgido en Europa en la década de los setenta llamado también Land Art. Cabe destacar, que hemos optado por incluir en este estudio únicamente la vertiente europea de Land Art, más que por la necesidad de acotar una investigación de esta índole, por las di...

  6. Valutazione del costo di due tipologie di infezioni ospedaliere

    Directory of Open Access Journals (Sweden)

    F. Abbona

    2003-05-01

    Full Text Available

    I tentativi di quantificare le risorse assorbite e definire i costi delle infezioni ospedaliere sono abbastanza sporadici e non sempre metodologicamente corretti. Il principale problema operativo consiste nell’identificare strumenti in grado di verificare sia l’eventuale eccesso di degenza attribuibile all’infezione, sia i costi diretti della infezione dovuti alle risorse impegnate per la diagnosi, il trattamento e l’eventuale monitoraggio del suo decorso.

    A tale scopo si è utilizzato uno strumento, il Protocollo di Revisione dell’Utilizzo dell’Ospedale (PRUO, specificamente modificato, per valutare se la presenza in ospedale era causata dalla sola infezione ospedaliera o dalla patologia di base. L’analisi così condotta permette di distinguere risorse e costi direttamente legati al trattamento delle infezioni da quelli legati alla patologia di base.

    Obiettivo: valutare il costo delle infezioni ospedaliere relative alle vie urinarie e alle sepsi, negli ospedali piemontesi.

    Metodi: la ricerca viene condotta nel periodo dicembre 2002 - settembre 2003, ed interessa 28 Ospedali, della Regione Piemonte, già precedentemente coinvolti (anno 2000 in uno studio di prevalenza sulle infezioni ospedaliere i cui pazienti rappresentano la base dati sulla quale sono stati scelti i casi (59 di infezione oggetto di studio. Per effettuare l’analisi si è proceduto alla consultazione della cartella clinica di ciascun paziente utilizzando il PRUO per raccogliere le informazioni relative alla durata della degenza attribuibile alla sola infezione ospedaliera, all’uso di antibiotici specifici, alle analisi di laboratorio e alle eventuali consulenze effettuate e valorizzando le diverse componenti dei costi con i valori economici forniti dall’ASO S. Luigi di Orbassano, articolati per unità operative in cui si è sviluppata l’infezione ospedaliera. Risultati: sono attualmente disponibili i

  7. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF); Scientific Opinion on Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The European Food Safety Authority (EFSA) asked the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs...... ether, three are alicyclic hydrocarbons with an ether side chain, two are ethers containing a benzene moiety, eight are phenol ethers and one is a naphthol ether. Five of the 19 candidate substances possess one or more chiral centres and three can exist as geometrical isomers. For one substance [FL...... by the Industry, especially in those cases where the annual production values were reported to be small. In consequence, the Panel had reservations about the data on use and use levels provided and the intake estimates obtained by the MSDI approach. In the absence of more precise information that would enable...

  8. Extraction of rare earth metals with 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester in the presence of diethylenetriaminepentaacetic acid in aqueous phase

    International Nuclear Information System (INIS)

    Kubota, Fukiko; Goto, Masahiro; Nakashio, Fumiyuki

    1993-01-01

    The extraction equilibria of rare earth metals with 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (commercial name, PC-88A, henceforth abbreviated as HR) dissolved in n-heptane were measured at 303 K. It was found that rare earth metals are extracted with the dimer of the extractant, (HR) 2 , as follows. M aq 3+ + 3(HR) 2 org MR 3 · 3HR org + 3H aq + The extraction equilibrium constants of metals were obtained and compared with the extraction equilibrium constants obtained by di(2-ethylhexyl)phosphoric acid (henceforth DZEHPA). Furthermore, the extraction equilibria of rare earth metals with PC-88A in the presence of diethylenetriaminepentaacetic acid (henceforth DTPA) in an aqueous phase were also measured to discuss the effect of DTPA on the extraction of rare earth metals. 13 refs., 8 figs., 2 tabs

  9. La filosofia clinica di Wittgenstein

    Directory of Open Access Journals (Sweden)

    Lorenzo Ghirelli

    2017-01-01

    Full Text Available Intento del presente saggio è quello di tracciare le linee principali della filosofia di Wittgenstein definendone l’orizzonte operativo e la strategia d’azione. Seguiremo inizialmente i cambiamenti nella concezione del linguaggio e del significato del filosofo austriaco utilizzandoli come traccia per registrare le corrispondenti revisioni degli obiettivi, delle tecniche e delle forme del far filosofia da lui proposte. Cercheremo poi di analizzare la pratica filosofica prospettata dal Wittgenstein maturo evidenziandone alcuni aspetti che ci consentiranno di qualificarla come clinica.

  10. Di-(2-Ethylhexyl Phthalate and Autism Spectrum Disorders

    Directory of Open Access Journals (Sweden)

    Chiara Testa

    2012-04-01

    Full Text Available ASDs (autism spectrum disorders are a complex group of neurodevelopment disorders, still poorly understood, steadily rising in frequency and treatment refractory. Extensive research has been so far unable to explain the aetiology of this condition, whereas a growing body of evidence suggests the involvement of environmental factors. Phthalates, given their extensive use and their persistence, are ubiquitous environmental contaminants. They are EDs (endocrine disruptors suspected to interfere with neurodevelopment. Therefore they represent interesting candidate risk factors for ASD pathogenesis. The aim of this study was to evaluate the levels of the primary and secondary metabolites of DEHP [di-(2-ethylhexyl phthalate] in children with ASD. A total of 48 children with ASD (male: 36, female: 12; mean age: 11 ± 5 years and age- and sex-comparable 45 HCs (healthy controls; male: 25, female: 20; mean age: 12 ± 5 years were enrolled. A diagnostic methodology, based on the determination of urinary concentrations of DEHP metabolites by HPLC-ESI-MS (HPLC electrospray ionization MS, was applied to urine spot samples. MEHP [mono-(2-ethylhexenyl 1,2-benzenedicarboxylate], 6-OH-MEHP [mono-(2-ethyl-6-hydroxyhexyl 1,2-benzenedicarboxylate], 5-OH-MEHP [mono-(2-ethyl-5-hydroxyhexyl 1,2-benzenedicarboxylate] and 5-oxo-MEHP [mono-(2-ethyl-5-oxohexyl 1,2-benzenedicarboxylate] were measured and compared with unequivocally characterized, pure synthetic compounds (>98% taken as standard. In ASD patients, significant increase in 5-OH-MEHP (52.1%, median 0.18 and 5-oxo-MEHP (46.0%, median 0.096 urinary concentrations were detected, with a significant positive correlation between 5-OH-MEHP and 5-oxo-MEHP (r s=0.668, P<0.0001. The fully oxidized form 5-oxo-MEHP showed 91.1% specificity in identifying patients with ASDs. Our findings demonstrate for the first time an association between phthalates exposure and ASDs, thus suggesting a previously unrecognized role for

  11. 40 CFR 721.522 - Oxirane, methyl-, polymer with oxirane, mono(3,5,5,-trimethylhexyl) ether.

    Science.gov (United States)

    2010-07-01

    ..., mono(3,5,5,-trimethylhexyl) ether. 721.522 Section 721.522 Protection of Environment ENVIRONMENTAL... Significant New Uses for Specific Chemical Substances § 721.522 Oxirane, methyl-, polymer with oxirane, mono(3...) The chemical substance identified as oxirane, methyl-, polymer with oxirane, mono(3,5,5...

  12. 21 CFR 582.4521 - Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Monosodium phosphate derivatives of mono- and... Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat-forming fatty acids. (a) Product. Monosodium phosphate derivatives of mono- and diglycerides of edible fats or...

  13. 40 CFR 721.1950 - 2-Butenedioic acid (Z), mono(2-((1-oxopropenyloxy)ethyl) ester .

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 2-Butenedioic acid (Z), mono(2-((1... Specific Chemical Substances § 721.1950 2-Butenedioic acid (Z), mono(2-((1-oxopropenyloxy)ethyl) ester . (a... 2-butenedioic acid (Z), mono(2-((1-oxopropenyloxy)ethyl) ester (PMN P-85-543) is subject to...

  14. Precise measurement of inner diameter of mono-capillary optic using X-ray imaging technique.

    Science.gov (United States)

    Kwon, Soonmu; Lim, Jae Hong; Namba, Yoshiharu; Chon, Kwon Su

    2017-11-16

    Mono-capillary optics have been applied to increase the performance of X-ray instruments. However, performance of a mono-capillary optic strongly depends on the shape accuracy, which is determined by the diameters of the inner hollow of the capillary along the axial direction. To precisely determine the inner diameter of the capillary optic used in X-ray imaging technique, which aims to replace the conventional method using a visible microscope. High spatial resolution X-ray images of the mono-capillary optic were obtained by a synchrotron radiation beamline. The inner diameter of the mono-capillary optic was measured and analyzed by the pixel values of the X-ray image. Edge enhancement effect was quite useful in determining the inner diameter, and the accuracy of the diameter determination was less than 1.32 μm. Many images obtained by scanning the mono-capillary optic along the axial direction were combined, and the axial profile, consisting of diameters along the axial direction, was obtained from the combined image. The X-ray imaging method could provide an accurate measurement with slope error of±19 μrad. Applying X-ray imaging technique to determine the inner diameter of a mono-capillary optic can contribute to increasing fabrication accuracy of the mono-capillary optic through a feedback process between the fabrication and measurement of its diameter.

  15. L'ISOLA DI ARTURO DI ELSA MORANTE

    African Journals Online (AJOL)

    User

    aria da alcuni anni interessi a volte definiti con la formula storicismo integrale, e una premessa per muoversi in questa direzione è naturalmente la disponibilità di un insieme di dati personali, che siamo molto lontani dal possedere. Nel campo ...

  16. CO 2 adsorption in mono-, di- and trivalent cation-exchanged metal-organic frameworks: A molecular simulation study

    KAUST Repository

    Chen, Yifei

    2012-02-28

    A molecular simulation study is reported for CO 2 adsorption in rho zeolite-like metal-organic framework (rho-ZMOF) exchanged with a series of cations (Na +, K +, Rb +, Cs +, Mg 2+, Ca 2+, and Al 3+). The isosteric heat and Henry\\'s constant at infinite dilution increase monotonically with increasing charge-to-diameter ratio of cation (Cs + < Rb + < K + < Na + < Ca 2+ < Mg 2+ < Al 3+). At low pressures, cations act as preferential adsorption sites for CO 2 and the capacity follows the charge-to-diameter ratio. However, the free volume of framework becomes predominant with increasing pressure and Mg-rho-ZMOF appears to possess the highest saturation capacity. The equilibrium locations of cations are observed to shift slightly upon CO 2 adsorption. Furthermore, the adsorption selectivity of CO 2/H 2 mixture increases as Cs + < Rb + < K + < Na + < Ca 2+ < Mg 2+ ≈ Al 3+. At ambient conditions, the selectivity is in the range of 800-3000 and significantly higher than in other nanoporous materials. In the presence of 0.1% H 2O, the selectivity decreases drastically because of the competitive adsorption between H 2O and CO 2, and shows a similar value in all of the cation-exchanged rho-ZMOFs. This simulation study provides microscopic insight into the important role of cations in governing gas adsorption and separation, and suggests that the performance of ionic rho-ZMOF can be tailored by cations. © 2012 American Chemical Society.

  17. Mono-, di- and trimeric PS I reaction center complexes isolated from the thermophilic cyanobacterium Synechococcus sp. Size, shape and activity

    NARCIS (Netherlands)

    Rögner, M.; Mühlenhoff, U.; Boekema, E.J.; Witt, H.T.

    1990-01-01

    Photosystem I preparations from the cyanobacterium Synechococcus sp. were treated with high concentrations of Tris and octyl glucoside at alkaline pH and elevated temperature. A sucrose density gradient yielded three pigment-protein complexes; these were further purified on a HPLC anion-exchange

  18. Poly[[diaqua-μ6-succinato-di-μ5-succinato-didysprosium(III)] mono­hydrate

    Science.gov (United States)

    Xu, Wei; Chang, Hai-Sheng; Guo, Xia-Xia

    2011-01-01

    The title compound, {[Dy2(C4H4O4)3(H2O)2]·H2O}n, is isostructural with other lanthanide succinates of the same formula. The DyIII atom is nine-coordinated in a tricapped trigonal–prismatic environment by eight O atoms, derived from six carboxyl­ate groups and a water mol­ecule. One of the independent succinate anions is located about a crystallographic inversion center and the uncoordinated water mol­ecule lies on a twofold axis. The crystal structure comprises edge-shared DyO9 polyhedra linked by succinate bridges, forming a three-dimensional network architecture. Intra- and inter­molecular O—H⋯O hydrogen bonds are present in the crystal structure. PMID:21836969

  19. Poly[[diaqua-μ(6)-succinato-di-μ(5)-succinato-didysprosium(III)] mono-hydrate].

    Science.gov (United States)

    Xu, Wei; Chang, Hai-Sheng; Guo, Xia-Xia

    2011-07-01

    The title compound, {[Dy(2)(C(4)H(4)O(4))(3)(H(2)O)(2)]·H(2)O}(n), is isostructural with other lanthanide succinates of the same formula. The Dy(III) atom is nine-coordinated in a tricapped trigonal-prismatic environment by eight O atoms, derived from six carboxyl-ate groups and a water mol-ecule. One of the independent succinate anions is located about a crystallographic inversion center and the uncoordinated water mol-ecule lies on a twofold axis. The crystal structure comprises edge-shared DyO(9) polyhedra linked by succinate bridges, forming a three-dimensional network architecture. Intra- and inter-molecular O-H⋯O hydrogen bonds are present in the crystal structure.

  20. Occurrence and origin of mono-, di- and trimethylalkanes in modern and Holocene cyanobacterial mats from Abu Dhabi, United Arab Emirates

    NARCIS (Netherlands)

    Sinninghe Damsté, J.S.; Kenig, F.; Kock-van Dalen, A.C.; Rijpstra, W.I.C.; Huc, A.Y.; Leeuw, J.W. de

    1995-01-01

    n-Alkanes, highly branched isoprenoids, monomethylalkanes (MMAs), dimethylalkanes (DMAs), and trimethylalkanes (TMAs) are the most abundant components in the hydrocarbon fractions of extracts of four modern and two Holocene cyanobacterial mats (1500 and 5110 ± 170 y ) collected in Abu Dhabi (United

  1. Prediction of mono- and di-nucleotide-specific DNA-binding sites in proteins using neural networks

    Directory of Open Access Journals (Sweden)

    Mizuguchi Kenji

    2009-05-01

    Full Text Available Abstract Background DNA recognition by proteins is one of the most important processes in living systems. Therefore, understanding the recognition process in general, and identifying mutual recognition sites in proteins and DNA in particular, carries great significance. The sequence and structural dependence of DNA-binding sites in proteins has led to the development of successful machine learning methods for their prediction. However, all existing machine learning methods predict DNA-binding sites, irrespective of their target sequence and hence, none of them is helpful in identifying specific protein-DNA contacts. In this work, we formulate the problem of predicting specific DNA-binding sites in terms of contacts between the residue environments of proteins and the identity of a mononucleotide or a dinucleotide step in DNA. The aim of this work is to take a protein sequence or structural features as inputs and predict for each amino acid residue if it binds to DNA at locations identified by one of the four possible mononucleotides or one of the 10 unique dinucleotide steps. Contact predictions are made at various levels of resolution viz. in terms of side chain, backbone and major or minor groove atoms of DNA. Results Significant differences in residue preferences for specific contacts are observed, which combined with other features, lead to promising levels of prediction. In general, PSSM-based predictions, supported by secondary structure and solvent accessibility, achieve a good predictability of ~70–80%, measured by the area under the curve (AUC of ROC graphs. The major and minor groove contact predictions stood out in terms of their poor predictability from sequences or PSSM, which was very strongly (>20 percentage points compensated by the addition of secondary structure and solvent accessibility information, revealing a predominant role of local protein structure in the major/minor groove DNA-recognition. Following a detailed analysis of results, a web server to predict mononucleotide and dinucleotide-step contacts using PSSM was developed and made available at http://sdcpred.netasa.org/ or http://tardis.nibio.go.jp/netasa/sdcpred/. Conclusion Most residue-nucleotide contacts can be predicted with high accuracy using only sequence and evolutionary information. Major and minor groove contacts, however, depend profoundly on the local structure. Overall, this study takes us a step closer to the ultimate goal of predicting mutual recognition sites in protein and DNA sequences.

  2. Sieving di-branched from mono-branched and linear alkanes using ZIF-8: experimental proof and theoretical explanation

    NARCIS (Netherlands)

    Ferreira, A.F.P.; Mittelmeijer-Hazeleger, M.C.; Granato, M.A.; Duarte Martins, V.F.; Rodrigues, A.E.; Rothenberg, G.

    2013-01-01

    We study the adsorption equilibrium isotherms and differential heats of adsorption of hexane isomers on the zeolitic imidazolate framework ZIF-8. The studies are carried out at 373 K using a manometric set-up combined with a micro-calorimeter. We see that the Langmuir model describes well the

  3. Bromine Incorporation in Regulated and Emerging DBPs and the Relative Predominance of Mono-, Di-, and Trihalogenated DBPs (Proceedings Paper)

    Science.gov (United States)

    Previous research has shown that bromine incorporation into trihalogenated acetic acids (TXAAs) was similar to that of the trihalomethanes (THMs). Likewise, occurrence data for other trihalogenated DBPs (e.g., halonitromethanes [HNMs], haloacetaldehydes [HAs]) showed similar or ...

  4. The wavelet transform for pre-processing IR spectra in the identification of mono- and di-substituted benzenes

    NARCIS (Netherlands)

    Bos, M.; Vrielink, J.A.M.

    1994-01-01

    This paper describes the wavelet transformation of IR spectra with the Daubechies analysing wavelet functions as a feature extracting method that successfully reduces the spectral data more than 20-fold with a significant improvement in the classification process.

  5. PET imaging of alphavbeta integrin expression in tumours with Ga-labelled mono-, di- and tetrameric RGD peptides

    NARCIS (Netherlands)

    Dijkgraaf, I.; Yim, C.B.; Franssen, G.M.; Schuit, R.C.; Luurtsema, G.; Liu, S.; Oyen, W.J.G.; Boerman, O.C.

    2011-01-01

    PURPOSE: Due to the restricted expression of alpha(v)beta(3) in tumours, alpha(v)beta(3) is considered a suitable receptor for tumour targeting. In this study the alpha(v)beta(3)-binding characteristics of (68)Ga-labelled monomeric, dimeric and tetrameric RGD peptides were determined and compared

  6. Biologically relevant mono- and di-nuclear manganese II/III/IV complexes of mononegative pentadentate ligands

    DEFF Research Database (Denmark)

    Baffert, Carole; Collomb, Marie-Nöelle; Deronzier, Alain

    2003-01-01

    were characterised by UV-visible spectroscopy, ESI mass spectrometry and cyclic voltammetry. In addition, III-IV and II-III species were electrochemically generated. Thus the new mononegative pentadentate ligand systems display significant flexibility in the range of Mn oxidation states and species...

  7. Bovine Induced Pluripotent Stem Cells Are More Resistant to Apoptosis than Testicular Cells in Response to Mono-(2-ethylhexyl Phthalate

    Directory of Open Access Journals (Sweden)

    Ying-Chu Lin

    2014-03-01

    Full Text Available Although the androgen receptor (AR has been implicated in the promotion of apoptosis in testicular cells (TSCs, the molecular pathway underlying AR-mediated apoptosis and its sensitivity to environmental hormones in TSCs and induced pluripotent stem cells (iPSCs remain unclear. We generated the iPSCs from bovine TSCs via the electroporation of OCT4. The established iPSCs were supplemented with leukemia inhibitory factor and bone morphogenetic protein 4 to maintain and stabilize the expression of stemness genes and their pluripotency. Apoptosis signaling was assessed after exposure to mono-(2-ethylhexyl phthalate (MEHP, the active metabolite of di-(2-ethylhexyl phthalate. Here, we report that iPSCs were more resistant to MEHP-induced apoptosis than were original TSCs. MEHP also repressed the expression of AR and inactivated WNT signaling, and then led to the commitment of cells to apoptosis via the cyclin dependent kinase inhibitor p21CIP1. The loss of the frizzed receptor 7 and the gain of p21CIP were responsible for the stimulatory effect of MEHP on AR-mediated apoptosis. Our results suggest that testicular iPSCs can be used to study the signaling pathways involved in the response to environmental disruptors, and to assess the toxicity of environmental endocrine disruptors in terms of the maintenance of stemness and pluripotency.

  8. Una questione di limiti. A proposito di "Fine pena: ora" di Elvio Fassone

    Directory of Open Access Journals (Sweden)

    Davide Galliani

    2016-04-01

    Full Text Available Il contributo inquadra entro la prospettiva di un nuovo diritto costituzionale penale alcune delle più rilevanti questioni approfondite nel libro di Elvio Fassone, "Fine pena: ora", Sellerio, 2015, in particolare il problema della ostatività e delle presunzioni legislative di tipo assoluto, basate sul diritto penale d'autore. Alla necessità di individualizzare il trattamento penitenziario sembrerebbe dover corrispondere un ruolo più incisivo del giudice, altrimenti spogliato delle sue più  importanti funzioni.

  9. Il museo della scienza di Villa Farnesina

    Directory of Open Access Journals (Sweden)

    Francesca Salvemini

    2005-02-01

    Full Text Available Rappresentavano l’Astronomia le due logge romane del viridario di villa Farnesina con la Sala adiacente del Trionfo di Ercole: lo spazio, l’astrolabio zodiacale della Sala di Galatea - in testa le stelle dell’Orsa minore fatte di “sasso” da Medusa, Peruzzi nella biografia di Vasari - e il tempo, la meccanica dello gnomone solare del Trionfo di Cupido.

  10. Il viaggio gastronomico di Paolo Monelli

    Directory of Open Access Journals (Sweden)

    Alberto Salarelli

    2013-01-01

    Full Text Available Il ghiottone errante di Paolo Monelli, pubblicato nel 1935, rappresenta uno dei primi esempi di narrativa di viaggio in tema di enogastronomia, un genere destinato a grande successo nel secondo dopoguerra. In questo articolo, oltre a ripercorrere la vicenda biografica di Monelli, si sottolineano le relazioni tra Il ghiottone e la cultura gastronomica del regime fascista, e si evidenziano alcuni tratti caratteristici del suo stile di scrittura.

  11. Il viaggio gastronomico di Paolo Monelli.

    OpenAIRE

    Salarelli, Alberto

    2013-01-01

    Il ghiottone errante di Paolo Monelli, pubblicato nel 1935, rappresenta uno dei primi esempi di narrativa di viaggio in tema di enogastronomia, un genere destinato a grande successo nel secondo dopoguerra. In questo articolo, oltre a ripercorrere la vicenda biografica di Monelli, si sottolineano le relazioni tra Il ghiottone e la cultura gastronomica del regime fascista, e si evidenziano alcuni tratti caratteristici del suo stile di scrittura. Paolo Monelli‟s Il ghiottone errante (The Wand...

  12. Diane Di Prima

    OpenAIRE

    Livingston, McKenzie

    2016-01-01

    Diane di Prima was one of the few female Beat writers, but she was just as prolific as her male contemporaries. Her writing style reflected the social upheavals of the day - like the other Beats, she dabbled in stream of consciousness and spontaneous prose, but gradually moved to more structured verse, like Haiku, published in 1967. She experimented heavily with form and diction to set herself apart from the male poets - exemplified in her epic poem, Loba. Her early texts focused heavily on p...

  13. Kriptosporidiosis di Indonesia

    Directory of Open Access Journals (Sweden)

    Tri Wijayanti

    2017-07-01

    Full Text Available ABSTRACTCryptosporidiosis included to waterborne and soil transmited diseases, caused by Cryptosporidium, obligat intraceluller pathogen organism. Cryptosporidium cause intestinal infection of human and animal acute diarrhea. Lung cryptosporidiosis on HIV/AIDS and tuberculosis  patients was reported. Diarrhea still be important health problem because diarrhea was be the third dominant contributor of children morbidity and mortality at some country include Indonesia. Every children have 1,6-2x diarrhea onset annually. Diarrhea cases caused by Cryptosporidium sp parasite was around 4-11%. Focus of this review is  about cryptosporidiosis on children, HIV/AIDS and tuberculosis patients, animal, environment, diagnostic and it’s prevention and control. Cryptosporidium species confirmed in Indonesia are C. wrairi, C. muris,  C. felis, C. hominis, C. meleagridis and C. parvum, indicated that there was a big rule of animal on Cryptosporidium transmission. Cryptosporidium was necessary to be one of diseases diagnose on HIV/AIDS and tuberculosis patients. Transmission of Cryptosporidium by  respiratory secretion (droplet, aerosol or contact with vomiting must be anticipated to prevent cryptosporidiosis especially on imunocompromissed/imunodeficiency people. Rapid Diagnostic Test that have highly sensitivity and spesificity is very important on Cryptosporidium cases finding and surveillance in Indonesia. Environment and cattle sanitation, personal hygiene, water and food treatment, is necessary to prevent cryptosporidiosis transmission.  Kriptosporidiosis termasuk waterborne dan soil transmitted diseases, disebabkan oleh Cryptosporidium yang bersifat obligat intraseluler. Cryptosporidium menyebabkan infeksi pada usus halus dan dapat menyebabkan diare akut pada manusia dan hewan. Kriptosporidiosis paru telah dilaporkan pada penderita HIV/AIDS dan tuberkulosis. Diare merupakan penyumbang utama ketiga angka kesakitan dan kematian anak di berbagai negara

  14. Develop mono-block tooth implants using automate design and FEM analysis

    OpenAIRE

    J.P. Alister; J. Moller,; F. Alister; R. Hunter

    2007-01-01

    Purpose: Purpose of this paper is present a new approach to modelling and design the low cost mono-block dental implants based on the integration of the computer aided techniques. This approach provides the automation of the design process of the mono-block dental implants.Design/methodology/approach: The approach used to develop the modelling and design of the mono-block dental implants are based on the parametrization of the main geometric features of the implants. This approach allows to ...

  15. A new approach to modelling and designing mono-block dental implants

    OpenAIRE

    R. Hunter; F. Alister; J. Möller; J. Alister

    2007-01-01

    Purpose: of this paper is present a new approach to modelling and design the low cost mono-block dental implants based on the integration of the computer aided techniques. This approach provides the automation of the design process of the mono-block dental implants.Design/methodology/approach: The approach used to develop the modelling and design of the mono-block dental implants are based on the parametrization of the main geometric features of the implants. This approach allows to generate ...

  16. Professional iPhone Programming with MonoTouch and .NET/C#

    CERN Document Server

    McClure, Wallace B; Dunn, Craig

    2010-01-01

    What .NET C# developers need to enter the hot field of iPhone apps. iPhone applications offer a hot opportunity for developers. Until the open source MonoTouch project, this field was limited to those familiar with Apple's programming languages. Now .NET and C# developers can join the party. This Wrox guide is the first book to cover MonoTouch, preparing developers to take advantage of this lucrative opportunity.: MonoTouch opens the field of iPhone app development to .NET and C# developers for the first time; the Wrox reputation among .NET developers assures them that this guide covers everyt

  17. MonoGame- ja Unity-ympäristöjen vertailu pelinkehityksessä

    OpenAIRE

    Pasanen, Rami

    2017-01-01

    Tutkielmassa verrataan MonoGamea ja Unitya pelinkehitysalustoina C#-kielellä. Tarkoituksena on selvittää MonoGamen ja Unityn eroja ja potentiaalisia vahvuuksia toisiinsa verrattuna, ensisijaisesti 2D-peleissä ja aloittelevan pelinkehittäjän näkökulmasta. Tutkimusmenetelmänä on kirjallisuuskatsaus ja vertailu molemmilla sovelluksilla toteutetun bullet hell -genreen sijoittuvan esimerkkipelin avulla. Sekä MonoGamen että Unityn toimintaan tutustutaan erillisissä luvuissa, ja tutustumisen jälkeen...

  18. KEANEKARAGAMAN HAYATI FLORA DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Cecep Kusmana

    2015-11-01

    Full Text Available Indonesia merupakan negara kepuluauan seluas sekitar 9 juta km2 yang terletak diantara dua samudra dan dua benua dengan jumlah pulau sekitar 17.500 buah yang panjang garis pantainya sekitar 95.181 km. Kondisi geografis tersebut menyebabkan negara Indonesia menjadi suatu negara megabiodiversitas walaupun luasnya hanya sekitar 1,3% dari luas bumi. Dalam dunia tumbuhan, flora di wilayah Indonesia termasuk bagian dari flora dari Malesiana yang diperkirakan memiliki sekitar 25% dari spesies tumbuhan berbunga yang ada di dunia yang menempati urutan negara terbesar ketujuh dengan jumlah spesies mencapai 20.000 spesies, 40%-nya merupakan tumbuhan endemik atau asli Indonesia. Negara Indonesia termasuk negara dengan tingkat keterancaman dan kepunahan spesies tumbuhan tertinggi di dunia. Saat ini tercatat sekitar 240 spesies tanaman dinyatakan langka, diantaranya banyak yang merupakan spesies tanaman budidaya. Selain itu, sekitar 36 spesies pohon di Indonesia dinyatakan terancam punah, termasuk kayu ulin di Kalimantan Selatan, sawo kecik di Jawa Timur, Bali Barat, dan Sumbawa, kayu hitam di Sulawesi, dan kayu pandak di Jawa serta ada sekitar 58 spesies tumbuhan yang berstatus dilindungi.Keywords: keanekaragaman hayati flora, megabiodiversitas, tingkat kepunahan, tumbuhan dilindungi, tumbuhan langka

  19. THE RECOGNITION OF SPOKEN MONO-MORPHEMIC COMPOUNDS IN CHINESE

    Directory of Open Access Journals (Sweden)

    Yu-da Lai

    2012-12-01

    Full Text Available This paper explores the auditory lexical access of mono-morphemic compounds in Chinese as a way of understanding the role of orthography in the recognition of spoken words. In traditional Chinese linguistics, a compound is a word written with two or more characters whether or not they are morphemic. A monomorphemic compound may either be a binding word, written with characters that only appear in this one word, or a non-binding word, written with characters that are chosen for their pronunciation but that also appear in other words. Our goal was to determine if this purely orthographic difference affects auditory lexical access by conducting a series of four experiments with materials matched by whole-word frequency, syllable frequency, cross-syllable predictability, cohort size, and acoustic duration, but differing in binding. An auditory lexical decision task (LDT found an orthographic effect: binding words were recognized more quickly than non-binding words. However, this effect disappeared in an auditory repetition and in a visual LDT with the same materials, implying that the orthographic effect during auditory lexical access was localized to the decision component and involved the influence of cross-character predictability without the activation of orthographic representations. This claim was further confirmed by overall faster recognition of spoken binding words in a cross-modal LDT with different types of visual interference. The theoretical and practical consequences of these findings are discussed.

  20. Fringing in MonoCam Y4 filter images

    International Nuclear Information System (INIS)

    Brooks, J.; Nomerotski, A.; Fisher-Levine, M.

    2017-01-01

    We study the fringing patterns observed in MonoCam, a camera with a single Large Synoptic Survey Telescope (LSST) CCD sensor. Images were taken at the U.S. Naval Observatory in Flagstaff, Arizona (NOFS) employing its 1.3 m telescope and an LSST y 4 filter. Fringing occurs due to the reflection of infrared light (700 nm or larger) from the bottom surface of the CCD which constructively or destructively interferes with the incident light to produce a net ''fringe'' pattern which is superimposed on all images taken. Emission lines from the atmosphere, dominated by hydroxyl (OH) spectra, can change in their relative intensities as the night goes on, producing different fringe patterns in the images taken. We found through several methods that the general shape of the fringe patterns remained constant, though with slight changes in the amplitude and phase of the fringes. We also found that a superposition of fringes from two monochromatic lines taken in the lab offered a reasonable description of the sky data.

  1. Antioxidant and cytotoxic activity of mono- and bissalicylic acid derivatives

    Directory of Open Access Journals (Sweden)

    Đurendić Evgenija A.

    2014-01-01

    Full Text Available A simple synthesis of mono- and bis-salicylic acid derivatives 1-10 by the transesterification of methyl salicylate (methyl 2-hydroxybenzoate with 3-oxapentane-1,5-diol, 3,6- dioxaoctane-1,8-diol, 3,6,9-trioxaundecane-1,11-diol, propane-1,2-diol or 1-aminopropan- 2-ol in alkaline conditions is reported. All compounds were tested in vitro on three malignant cell lines (MCF-7, MDA-MB-231, PC-3 and one non-tumor cell line (MRC- 5. Strong cytotoxicity against prostate PC-3 cancer cells expressed compounds 3, 4, 6, 9 and 10, all with the IC50 less than 10 μmol/L, which were 11-27 times higher than the cytotoxicity of antitumor drug doxorubicin. All tested compounds were not toxic against the non-tumor MRC-5 cell line. Antioxidant activity of the synthesized derivatives was also evaluated. Compounds 2, 5 and 8 were better OH radical scavengers than commercial antioxidants BHT and BHA. The synthesized compounds showed satisfactory scavenger activity, which was studied by QSAR modeling. A good correlation between the experimental variables IC50 DPPH and IC50 OH and MTI (molecular topological indices molecular descriptors and CAA (accessible Connolly solvent surface area for the new compounds 1, 3, and 5 was observed.

  2. Jurnalisme Tabloid di Indonesia

    Directory of Open Access Journals (Sweden)

    Diyah Hayu Rahmitasari

    2013-12-01

    Full Text Available Abstract: Many scholars have criticised tabloid journalism because it often contains drama and sensationalism. However, tabloid journalism actually cater the taste of the readers who were ignored by mainstream newspapers. This article is based on a research analyse Pos Kota and Lampu Hijau, relying on content analysis of the papers’ editions in December 2011 and January 2012, as well as interviews with the editors and journalists. The analyses conclude that tabloid journalism in Indonesia is an urban phenomenon focuses on local issues and targets urban workers as their core readers and has been most successful in Jakarta and its surrounds. Abstrak: Jurnalisme tabloid merupakan terminologi yang sering diperdebatkan, dikritisi dan dicaci. Padahal, bentuk jurnalisme ini sebenarnya melayani selera pembaca yang cenderung diabaikan oleh jurnalisme arus utama. Artikel ini dibuat berdasarkan penelitian atas isi Pos Kota dan Lampu Hijau periode Desember 2011-Januari 2012, serta wawancara dengan editor dan jurnalis. Hasil analisis menunjukkan bahwa jurnalisme tabloid di Indonesia adalah jurnalisme yang fokus pada isu-isu lokal dan menyasar para pekerja urban sebagai pembaca utamanya sehingga meraih sukses di kota-kota besar terutama Jakarta dan sekitarnya.

  3. Isu Perkawinan Minoritas di Thailand

    Directory of Open Access Journals (Sweden)

    Nur Triyono

    2016-06-01

    Masyarakat dalam sebuah negara biasanya terbagi dalam dua kelompok besar, kelompok mayoritas dan kelompok minoritas. Kelompok mayoritas biasanya memegang kendali dalam setiap kebijakan yang akan dilaksanakan dalam lingkungan masyarakat tersebut, sementara kelompok minoritas terkadang dapat ikut berperan di dalamnya dan terkadang juga tidak mendapatkan peran apapun dalam melaksanakan sebuah kebijakan di lingkungan tersebut. Negara Thailand merupakan memiliki keunikan tersendiri, karena selain tetap memegang kebijakan dalam melaksanakan perkawinan adat ketimuran yang kental dengan nilai-nilai budaya Thailand, negara gajah putih ini juga memberikan ruang kepada perkawinan kelompok minoritas yang ada di negara itu. Perkawinan minoritas yang terjadi di negara ini antara lain adalah isu perkawinan sejenis yang dilakukan oleh kelompok minoritas LGBT dan isu perkawinan beda agama yang umumnya terjadi antara mereka yang beragama Islam dan Buddha di wilayah Thailand Selatan.

  4. I dolori di Claudia Seeliger

    Directory of Open Access Journals (Sweden)

    Uta Treder

    2015-01-01

    Full Text Available La protagonista di questo romanzo dice “io”, si confida con noi, ci conduce attraverso la sua rocambolesca vicenda tenendoci avvinti e costringendoci ad esserle complici. Più di una volta restiamo col fiato sospeso, ci sentiamo a tratti confusi e smarriti, scuotiamo la testa disapprovando le sue scelte avventate, ma non ce la sentiremmo mai di abbandonarla al suo destino. Troppo forte è la sua personalità, perfino laddove scopre il suo lato fragile, troppo coinvolgente la sua passione, troppo disarmante la sua intelligenza. Non c’è niente da fare: Claudia Seeliger ci tiene in pugno. Claudia Seeliger, o chi per lei, bisognerebbe dire… In questo romanzo poliziesco, psicologico, erotico, politico, interculturale e intertestuale, Uta Treder si rivela narratrice sapiente, colta, ma anche ironica e assai irriverente. Profilo biograficoUta Treder (Amburgo 1943 – Firenze 2013 è stata professore ordinario di Storia della cultura tedesca a Firenze e di Letteratura tedesca a Trieste e a Perugia. Da germanista si è occupata di autori quali Goethe, Schiller, Hölderlin, Novalis, Heine, Droste-Hülshoff, Fontane, Keller, Lasker-Schüler, Kafka, Bachmann, Mayröcker. Il suo principale interesse ha riguardato la letteratura delle donne che sono state "dimenticate" dal Canone. Come autrice di narrativa ha pubblicato la raccolta di racconti Luna Aelion (München 1989 e i romanzi Die Alchemistin (Frankfurt a.M. 1993, Die Bäume von Babelsberg (Pfalzfeld 2005, audiolibro letto da Petra Pawel, 2007; anticipazione italiana in "LEA", 1-2004, Der Schwarze König (Pfalzfeld 2007. È stata socia fondatrice della Società Italiana delle Letterate. I dolori di Claudia Seeliger è la prima traduzione italiana dell'opera narrativa di Uta Treder.

  5. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2005-12-01

    Full Text Available Report of PhD Dissertations.Anna Airò La scrittura delle regole. Politica e istituzioni a Taranto nel Quattrocento, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Pasquale Arfé La Clavis Physicae II (316-529 di Honorius Augustodunensis. Studio ed edizione critica, Tesi di dottorato in Storia della filosofia medievale, Università degli Studi di Napoli "L'Orientale", 2005 Alessandro Azzimonti Scrittura agiografica e strutture di potere nell'Italia centro-settentrionale (X-XII secolo, Tesi di dottorato di ricerca in Forme del sapere storico dal medioevo alla contemporaneità, Università degli Studi di Trieste, 2004 Domenico Cerami Il "Confine conteso". Uomini, istituzioni, culture a Monteveglio tra VIII-XII secolo, Tesi di dottorato di ricerca in Storia Medievale, Università degli studi di Bologna, 2005 Federica Chilà Ostaggi. Uno strumento di pacificazione e governo tra i secoli VIII e XII, Tesi di dottorato di ricerca in Istituzioni, società, religioni dal Tardo Antico alla fine del Medioevo, Università degli Studi di Torino, 2004 Enrico Faini Firenze nei secoli X-XIII: economia e società, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005Alessio FioreStrutture e pratiche del potere signorile in area umbro-marchigiana (secoli XI-XIII, Tesi di dottorato ricerca in Storia, Università degli studi di Pisa, 2004Giampaolo FrancesconiTra Riforma, vescovo e clientes. Camaldoli e le società locali (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [09/05] Giuseppe Gardoni "Episcopus et potestas". Vescovi e società a Mantova nella prima metà del Duecento, Tesi di dottorato di ricerca in Storia del Cristianesimo e delle Chiese (antichità, medioevo, età moderna, Università degli Studi di Padova, 2005 Nicola Mancassola La gestione delle campagne tra Langobardia e Romània in età carolingia e post

  6. Esercizi di fisica meccanica e termodinamica

    CERN Document Server

    Dalba, G

    2006-01-01

    La risoluzione di esercizi rappresenta uno strumento indispensabile per raggiungere una comprensione sicura e approfondita dei concetti di Fisica appresi dai corsi e dai testi di teoria. Frutto di una lunga esperienza didattica dei due autori nell'insegnamento universitario della meccanica e della termodinamica, questa raccolta contiene 188 esercizi, di cui 91 completamente risolti ed accompagnati da un ampio corredo di figure. Il peimo capitolo presenta un'introduzione ai sistemi di unità di misura, al calcolo dimensionale, all'uso corretto delle cifre significative e degli arrotondamenti, ai grafici. Gli altri capitoli contengono gli esercizi, suddivisi per argomento e preceduti da una serie di paragrafi riassuntivi dei concetti fondamentali. Criterio ispiratore di questo lavoro è l'adozione di una metodologia per la soluzione degli esercizi basata sempre sull'analisi accurata dei dati a disposizione e sul riferimento ai principi e alle leggi della Fisica, mai alla sola intuizione.

  7. Developing C# Apps for iPhone and iPad using MonoTouch

    CERN Document Server

    Costanich, Bryan

    2011-01-01

    Developing C# Applications for iPhone and iPad using MonoTouch shows you how to use your existing C# skills to write apps for the iPhone and iPad. Fortunately, there's MonoTouch, Novell's .NET library that allows C# developers to write C# code that executes in iOS. Furthermore, MonoTouch allows you to address all the unique functions of the iPhone, iPod Touch, and iPad. And the big plus: You needn't learn any Objective-C to master MonoTouch!. Former Microsoft engineer and published app-store developer Bryan Costanich shows you how to use the tools you already know to create native apps in iOS

  8. Self-Assembly of Mono- and Dinuclear Metal Complexes; Oxidation Catalysis and Metalloenzyme Models

    NARCIS (Netherlands)

    Gelling, Onko-Jan; Rispens, Minze T.; Lubben, Marcel; Feringa, Bernard

    1994-01-01

    In this chapter several approaches to achieve assembly of mono- and dinuclear metal complexes, which can be considered structural and functional models for metalloenzymes, are described. The emphasis lies on oxidation chemistry, summarizing O2 binding, hydroxylation, demethylation, dehalogenation

  9. Mono-Cycle Photonics and Optical Scanning Tunneling Microscopy Route to Femtosecond Ångstrom Technology

    CERN Document Server

    Yamashita, Mikio; Morita, Ryuji

    2005-01-01

    "Mono-Cycle Photonics and Optical Scanning Tunneling Microscopy" deals with both the ultrashort laser-pulse technology in the few- to mono-cycle region and the laser-surface-controlled scanning-tunneling microscopy (STM) extending into the spatiotemporal extreme technology. The former covers the theory of nonlinear pulse propagation beyond the slowly-varing-envelope approximation, the generation and active chirp compensation of ultrabroadband optical pulses, the amplitude and phase characterization of few- to mono-cycle pulses, and the feedback field control for the mono-cycle-like pulse generation. In addition, the wavelength-multiplex shaping of ultrabroadband pulse is described. The latter covers the CW-laser-excitation STM, the femtosecond-time-resolved STM and atomic-level surface phenomena controlled by femtosecond pulses.

  10. Storia di Lea Garofalo e di sua figlia Denise

    Directory of Open Access Journals (Sweden)

    Anna Lisa Tota

    2017-11-01

    Full Text Available Questo articolo analizza il caso di Lea Garofalo e le modalità, attraverso cui la sua memoria è stata iscritta nel discorso pubblico italiano. In particolare, focalizza l’attenzione sul film “Lea” di Marco Tullio Giordana, dedicato appunto alla storia del femminicidio di Lea Garofalo e alla storia di sua figlia Denise Cosco. Questo caso è emblematico, in quanto mette a tema il destino e le difficoltà che incontrano le donne, quando decidono di opporsi e resistere alla cultura mafiosa e criminale delle famiglie, di cui fanno parte. Inoltre, esso sfida quegli stereotipi, ancora largamente diffusi nel senso comune, secondo i quali questi fenomeni di criminalità organizzata sarebbero diffusi prevalentemente nel sud del nostro paese. Di fatto questo femminicidio dell’n’drangheta avviene a Milano e riguarda attività criminali organizzate nel capoluogo lombardo. Parole chiave: Memoria pubblica, femminicidio, lotta alla criminalità organizzata, testimoni di giustizia   This article deals with Lea Garofalo’s case and the forms that have shaped its cultural memory in the Italian public discourse. Its main focus is related to “Lea”, the movie by the Italian filmmaker Marco Tullio Giordana on the story of this femicide and the relation between Lea Garofalo and her daughter named Denise Cosco. This case is exemplary, because it concerns the destine and the difficulties encountered by women, when they decide to contrast and resist against the mafiosi culture of the families, to which they belong. Moreover, it challenges those stereotypes, still very common, according to which mafia’s and camorra’s criminal activities are overspread mainly in South Italy. This femicide has been committed by n’drangheta in the centre of Milan and it is caused through criminal activities that  took place in the North part of the country. Keywords: Public memory, femicide, fight against organized crime, witnesses

  11. Geothermal systems of the Mono Basin-Long Valley region, eastern California and western Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Higgins, C.T.; Flynn, T.; Chapman, R.H.; Trexler, D.T.; Chase, G.R.; Bacon, C.F.; Ghusn, G. Jr.

    1985-01-01

    The region that includes Mono Basin, Long Valley, the Bridgeport-Bodie Hills area, and Aurora, in eastern California and western Nevada was studied to determine the possible causes and interactions of the geothermal anomalies in the Mono Basin-Long Valley region as a whole. A special goal of the study was to locate possible shallow bodies of magma and to determine their influence on the hydrothermal systems in the region. (ACR)

  12. Generalized dynamic model and control of ambiguous mono axial vehicle robot

    Directory of Open Access Journals (Sweden)

    Frantisek Duchon

    2016-09-01

    Full Text Available This article deals with the novel concept of ambiguous mono axial vehicle robot. Such robot is a combination of Segway and dicycle, which utilizes the advantages of each chassis. The advantage of dicycle is lower energy consumption during the movement and the higher safety of carried payload. The movable platform inside the ambiguous mono axial vehicle allows using the various sensors or devices. This will change the ambiguous mono axial vehicle to the Segway type robot. Both these modes are necessary to control in the stable mode to ensure the safety of the ambiguous mono axial vehicle’s movement. The main contents of the article contain description of generalized dynamic model of ambiguous mono axial vehicle and related control of ambiguous mono axial vehicle. The proposal is unique in that the same controller is used for both modes. Several simulations verify proposed control schemes and identified parameters. Moreover, the dicycle type of platform has never been used in robotics and that is another novelty.

  13. Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes.

    Science.gov (United States)

    Wang, Bei; Suzuki, Hiroyuki; Kato, Mitsuyasu

    2008-11-14

    TGF-beta activates receptor-regulated Smad (R-Smad) through phosphorylation by type I receptors. Activated R-Smad binds to Smad4 and the complex translocates into the nucleus and stimulates the transcription of target genes through association with co-activators including p300. It is not clear, however, how activated Smad complexes are removed from target genes. In this study, we show that TGF-beta enhances the mono-ubiquitination of Smad4. Smad4 mono-ubiquitination was promoted by p300 and suppressed by the c-Ski co-repressor. Smad4 mono-ubiquitination disrupted the interaction with Smad2 in the presence of constitutively active TGF-beta type I receptor. Furthermore, mono-ubiquitinated Smad4 was not found in DNA-binding Smad complexes. A Smad4-Ubiquitin fusion protein, which mimics mono-ubiquitinated Smad4, enhanced localization to the cytoplasm. These results suggest that mono-ubiquitination of Smad4 occurs in the transcriptional activator complex and facilitates the turnover of Smad complexes at target genes.

  14. Effect of Subgrains on the Performance of Mono-Like Crystalline Silicon Solar Cells

    Directory of Open Access Journals (Sweden)

    Su Zhou

    2013-01-01

    Full Text Available The application of Czochralski (Cz monocrystalline silicon material in solar cells is limited by its high cost and serious light-induced degradation. The use of cast multicrystalline silicon is also hindered by its high dislocation densities and high surface reflectance after texturing. Mono-like crystalline silicon is a promising material because it has the advantages of both mono- and multicrystalline silicon. However, when mono-like wafers are made into cells, the efficiencies of a batch of wafers often fluctuate within a wide range of >1% (absolute. In this work, mono-like wafers are classified by a simple process and fabricated into laser doping selective emitter cells. The effect and mechanism of subgrains on the performance of mono-like crystalline silicon solar cells are studied. The results show that the efficiency of mono-like crystalline silicon solar cells significantly depends on material defects that appear as subgrains on an alkaline textured surface. These subgrains have an almost negligible effect on the optical performance, shunt resistance, and junction recombination but significantly affect the minority carrier diffusion length and quantum efficiency within a long wavelength range. Finally, an average efficiency of 18.2% is achieved on wafers with hardly any subgrain but with a small-grain band.

  15. Good quality blastocyst from non-/mono-pronuclear zygote may be used for transfer during IVF.

    Science.gov (United States)

    Yin, Bao-Li; Hao, Hao-Ying; Zhang, Ya-Nan; Wei, Duo; Zhang, Cui-Lian

    2016-01-01

    Although healthy infants have developed from non- and mono-pronuclear zygotes, the transfer of embryos from non- and mono-pronuclear zygotes is not recommended because there are no proper selection criteria. In the present study, we discuss how to select non- and mono-pronuclear embryos with the highest developmental potential at 19-20 hours post-insemination. We found that the percentage of blastocysts with normal chromosome constitution in non-pronuclear zygotes was slightly higher than in mono-pronuclear zygotes. Non- and mono-pronuclear embryos that were at the 4-cell stage on D2 and/or at the 6- to 8-cell stage on D3 had higher incidence rates of blastocysts with normal chromosome constitutions. We also found higher incidences of blastocysts with normal chromosome constitution on D6 than on D5. The results suggest that if high quality non- and mono-pronuclear zygotes develop to the 4-cell stage on D2 and the 6-to 8- cell stages on D3, along with high quality D6 blastocysts, the incidence of blastocysts with normal chromosome constitution is higher.

  16. Teoria dei quanti di luce

    CERN Document Server

    Einstein, Albert

    1992-01-01

    In questo scritto un’intuizione storica limpida e penetrante, con la quale il giovane Einstein pose le basi per i successivi studi sulla teoria della relatività, è consegnata al lettore in forma chiara ed essenziale. Nel 1905, appena ventiseienne, Einstein intervenne nel dibattito sulle leggi di distribuzione della radiazione luminosa che all’epoca animava gli ambienti scientifici e che si inseriva nel più ampio processo di revisione delle scienze fisiche e naturali. Il giovane scienziato tentò di dimostrare come «...una radiazione monocromatica di densità ridotta... si comporta, per quanto riguarda la termodinamica, come se fosse composta da quanti di energia indipendenti l’uno dall’altro». In altre parole, nel caso limite di basse temperature e piccole lunghezze d’onda, la teoria ondulatoria della luce, tradizionalmente accettata e riconosciuta dai fisici, sembrava destituita di ogni fondamento, e si faceva strada l’ipotesi che la radiazione viaggiasse “a pacchetti”. Lo sviluppo succe...

  17. Coaxial Mono-Energetic Gamma Generator for Active Interrogation

    Energy Technology Data Exchange (ETDEWEB)

    Ludewigt, Bernhard A.; Antolak, A.J.; Henestroza, E.; Leitner, M.; Leung, K.-N.; Waldron, W.; Wilde, S.; Kwan, J.W.

    2008-08-01

    Compact mono-energetic photon sources are sought for active interrogation systems to detect shielded special nuclear materials in, for example, cargo containers, trucks and other vehicles. A prototype gamma interrogation source has been designed and built that utilizes the 11B(p,gamma)12C reaction to produce 12 MeV gamma-rays which are near the peak of the photofission cross section. In particular, the 11B(p,gamma)12C resonance at 163 kV allows the production of gammas at low proton acceleration voltages, thus keeping the design of a gamma generator comparatively small and simple. A coaxial design has been adopted with a toroidal-shaped plasma chamber surrounding a cylindrical gamma production target. The plasma discharge is driven by a 2 MHz rf-power supply (capable up to 50 kW) using a circular rf-antenna. Permanent magnets embedded in the walls of the plasma chamber generate a multi-cusp field that confines the plasma and allows higher plasma densities and lower gas pressures. About 100 proton beamlets are extracted through a slotted plasma electrode towards the target at the center of the device that is at a negative 180 kV. The target consists of LaB6 tiles that are brazed to a water-cooled cylindrical structure. The generator is designed to operate at 500 Hz with 20 mu s long pulses, and a 1percent duty factor by pulsing the ion source rf-power. A first-generation coaxial gamma source has been built for low duty factor experiments and testing.

  18. Di - lambpha cluster states

    International Nuclear Information System (INIS)

    Motoba, Toshio

    1982-01-01

    The lightest (p, n, Λ) closed-shell hypernucleus sub(ΛΛ) sup(6)He can be considered as a most likely candidate for the unit of hypernuclear cluster structure. First the internal structure of lambpha, α sub(Λ) = sub(ΛΛ) sup(6)He, is investigated by solving the α + Λ + Λ three-body problem microscopically. The compact h. o. wave function (0 s) 6 is found to be a good description for α sub(Λ). Secondly, by using the fully microscopic GCM, we have demonstrated that di - α sub(Λ) cluster states constitute a characteristic rotational band of J = 0 + -- 6 + . The E2 transition rate from particle - stable 2 + to 0 + states is predicted to be 2 - order faster than the weak decay rate of this system. (author)

  19. Compendio di meccanica razionale

    CERN Document Server

    Levi-Civita, Tullio

    1948-01-01

    Questa seconda edizione, pur conforme nel suo complesso alla precedente, ha subìto un'accurata revisione generale e svariati ritocchi particolari. Ci limitiamo qui a rivelare che nella I Parte abbiamo aggiunto un'analisi della nozione di "tempo", diretta a lumeggiare il momento preciso del distacco fra l'impostazione classica della Meccanica e della Fisica e quelle relativistica; e, per quel che concerne la Statica, vi abbiamo inquadrato, senza ammissioni estranee, la determinazione delle reazioni nel cosidetto "arco a tre cerniere" e ridotto a forma didatticamente più semplie ed espressiva il paragrafo sull'"attrito volvente". Nella II Parte abbiamo ulteriormente semplificato la teoria elementare dei "fenomeni giroscopici", seguendo G. Bisconcini.

  20. MOTIVARE, GIOCARE, APPRENDERE. UN ESPERIMENTO DI GAME BASED LEARNING TOTALE IN UN CORSO DI ITALIANO LS

    OpenAIRE

    Schenetti, Davide

    2017-01-01

    Questo articolo presenta lo sviluppo e la valutazione di un’esperienza totale di uso di giochi digitali in un contesto di Italiano LS con un piccolo gruppo di discenti di livello superiore. Dopo la definizione dei concetti di Digital Game Based Learning e Gamification, si fornirà una panoramica sugli studi rilevanti nel campo, con particolare interesse all’aspetto motivazionale dell’apprendente e all’applicazione in contesti di insegnamento di una lingua straniera. Nella seconda parte dell’ar...

  1. La Basilica di Vitruvio di Fano: un approccio di archeologia sperimentale per la validazione di un modello 3D

    Directory of Open Access Journals (Sweden)

    Paolo Clini

    2014-04-01

    Full Text Available IT La vicenda della Basilica di Vitruvio di Fano ha da sempre destato un grande interesse tra studiosi e archeologi e da diversi anni è oggetto di studio di un gruppo di ricerca del DICEA della Facoltà d’Ingegneria dell’Università Politecnica delle Marche di Ancona, in collaborazione con il Centro Studi Vitruviani. Seppur già lungamente nei secoli si è discusso sull’interpretazione del testo, limitandosi però a descrizioni formali della fabbrica, il nostro interesse si è invece concentrato, grazie anche allo sviluppo tecnologico di questi ultimi decenni, sugli aspetti statici e strutturali dell’unico edificio di cui Vitruvio curò la progettazione e la realizzazione. E’ stato quindi possibile realizzare un modello virtuale su cui effettuare una serie di simulazioni strutturali e illuminotecniche, secondo i canoni dell’archeologia sperimentale. Con un approccio volto sempre più all’interdisciplinarietà, ripercorrendo criticamente la storiografia della basilica, il lavoro apre nuove riflessioni su un’ipotesi in cui la forma, la struttura e le tecniche costruttive possono finalmente concordare permettendoci così, interagendo reciprocamente, di aprire nuovi ambiti di ipotesi rispetto al mancato ritrovamento di resti e ai possibili motivi della eventuale scomparsa della fabbrica.ENVitruvius’s Basilica has always been a subject of great interest among academics and archaeologists and it has been investigated by the engineering department of Marche Polytechnic University of Ancona, in partnership with Centro Studi Vitruviani for many years now. Even though the discussion about the text interpretation went on for a long time during the centuries, mainly concerning the shape of the building, on the other hand our interest, due to the technological progress of the last decades, is focused on static and structural features of the only building that Vitruvius drew and built. Thus it was possible to reproduce structural and

  2. I dolori di Claudia Seeliger

    OpenAIRE

    Uta Treder

    2015-01-01

    La protagonista di questo romanzo dice “io”, si confida con noi, ci conduce attraverso la sua rocambolesca vicenda tenendoci avvinti e costringendoci ad esserle complici. Più di una volta restiamo col fiato sospeso, ci sentiamo a tratti confusi e smarriti, scuotiamo la testa disapprovando le sue scelte avventate, ma non ce la sentiremmo mai di abbandonarla al suo destino. Troppo forte è la sua personalità, perfino laddove scopre il suo lato fragile, troppo coinvolgente la sua passione, troppo...

  3. Manuale di esercizi in fisica delle particelle

    CERN Document Server

    Cartiglia, Nicolo

    2015-01-01

    Questi esercizi nascono come raccolta delle esercitazioni preparate per il corso in Fisica delle particelle" tenuto dalla prof.ssa R. Cester all'università di Torino e quelle per il corso in Particle Physics offerto all'Universita della California (UCSC) dal prof. A. Seiden. Durante gli anni del corso, il numero e gli argomenti trattati nei problemi sono cresciuti fino a far diventare questa collezione uno strumento a se stante, utile per la preparazione sia di esami che di prove di dottorato. Il livello di difficoltà dei problemi varia da elementare a decisamente complessi, per offrire un'ampia possibilita di scelta. Gli argomenti affrontati negli esercizi seguono quelli del corso base in Fisica delle particelle, mentre non si trovano esercizi avanzati di QCD e teoria elettrodebole. Una breve introduzione teorica permette di rivedere i concetti di base, mentre la bibliografia riporta una collezione di testi che servono per gli approfondimenti.

  4. Structures of mono-unsaturated triacylglycerols. IV. The highest melting β'-2 polymorphs of trans-mono-unsaturated triacylglycerols and related saturated TAGs and their polymorphic stability

    NARCIS (Netherlands)

    van Mechelen, J.B.; Peschar, R.; Schenk, H.

    2008-01-01

    The β1'-2 crystal structures of a series of mixed-chain saturated and trans-mono-unsaturated triacylglycerols containing palmitoyl, stearoyl and elaidoyl acyl chains have been solved from high-resolution powder diffraction data, from synchrotron as well as laboratory X-ray sources. The structures

  5. La lunga attesa di Marsis

    Directory of Open Access Journals (Sweden)

    Fabrizio Bernardini

    2005-10-01

    Full Text Available Abbiamo parlato in altre occasioni di MARSIS e della sua progenie SHARAD, due esperimenti italiani per la misura di caratteristiche sottosuperficiali del pianeta Marte. Prodotti innovativi ed unici che nascondono un potenziale scientifico elevato. La strada per Marte però non è così facile come può sembrare e se la realizzazione degli strumenti non è stata esente da dolori, l’interpretazione e la divulgazione dei risultati non sono da meno. Le incertezze ed i dubbi sono però ora dissipati: l’esperimento MARSIS funziona perfettamente e per la prima volta nella storia dell’umanità abbiamo uno strumento e gli elementi per capire cosa c’è nel sottosuolo di un altro pianeta, senza aver inviato sul posto geologi ne’ tantomeno squadre per movimenti di terra.

  6. KEANEKARAGAMAN JENIS DAN SEBARAN FAGACEAE DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Purwaningsih Purwaningsih

    2016-01-01

    Full Text Available Fagaceae umumnya pohon, salah satu suku dengan jumlah jenis yang cukup besar ± 700 jenis di dunia tetapi sebagian besar tumbuh di belahan bumi utara. Di wilayah Malesia, ada lima marga yaitu Nothofagus, Castanopsis, Lithocarpus, Quercus dan Trigonobalanus dan jumlah jenis ± 180 dan sebagian besar di Indonesia tercatat 112 jenis. Penelitian ini dilakukan dengan studi literatur untuk menentukan keanekaragaman jenis Fagaceae di Indonesia serta distribusi dan pemanfaatannya. Fagaceae paling banyak tumbuh di Indonesia adalah marga Lithocarpus (60 jenis dan Castanopsis (24 jenis, sementara Nothofagus (11 jenis sebarannya hanya di Papua. Distribusi jenis Lithocarpus paling di Sumatera (29 jenis dan Kalimantan (26 jenis, sementara Castanopsis paling banyak di Kalimantan (15 jenis. Untuk Nusa Tenggara tidak ditemukan jenis-jenis Fagaceae dan ke arah timur Indonesia semakin sedikit jumlah jenisnya, di Sulawesi dan Maluku hanya diketemukan satu jenis. Sebaran Fagaceae dipengaruhi oleh beberapa faktor, terutama tanah, iklim, dan ketinggian. Di Indonesia habitat tumbuh Fagaceae di hutan yang masih alami, tetapi ada beberapa yang mampu tumbuh di rawa seperti Nothofagus womersleyi. Berdasarkan ketinggian tempat (altitude umumnya Fagaceae di hutan submontane dengan ketinggian 600-1500 m namun ada beberapa spesies yang mampu tumbuh hingga ketinggian >3000 m. Fagaceae yang memiliki sebaran luas (ditemukan di beberapa pulau ada dua jenis yaitu Castanopsis acuminatissima dan Lithocarpus elegans. Pada umumnya pemanfaatan Fagaceae adalah kayunya untuk bahan bangunan dan furniture tetapi ada jenis Castanopsis yang dapat dimakan bijinya dan selain itu kulit kayu mengandung tanin bisa untuk pewarna.

  7. Comparison between mono-bloc and bi-bloc mandibular advancement devices for obstructive sleep apnea.

    Science.gov (United States)

    Lee, Woo Hyun; Wee, Jee Hye; Lee, Chul Hee; Kim, Min-Su; Rhee, Chae-Seo; Yun, Pil-Young; Yoon, In-Young; Kim, Jeong-Whun

    2013-11-01

    Although mandibular advancement device (MAD) is widely used, there are a few papers comparing the efficacy and compliance at the same time according to the type of MAD. The aim of this study is to compare the efficacy and compliance between mono-bloc and bi-bloc MAD in the treatment of obstructive sleep apnea (OSA). Ninety-three patients who treated with mono-bloc MAD and 60 patients with bi-bloc MAD from January 2007 through September 2011 were retrospectively enrolled. All the patients underwent full-night polysomnography(PSG) before and 3 months after MAD was applied. The response rate was significantly higher in the patients using mono-bloc than those using bi-bloc MAD (77.4 vs. 58.3 %; P = 0.012). In contrast, the compliance rate of MAD use was significantly higher in the patients using bi-bloc than those using mono-bloc MAD (68.8 vs. 83.3 %; P = 0.044) at 1 year. According to the severity of OSA, the response rate was significantly higher in severe OSA than in mild to moderate OSA (P = 0.033 for mono-bloc MAD and P = 0.048 for bi-bloc MAD). However, there was no difference in the compliance between mild to moderate OSA and severe OSA. Our study showed that mono-bloc MAD was superior to bi-bloc MAD in efficacy while bi-bloc MAD is superior to mono-bloc MAD in compliance. We propose that both the efficacy and compliance should be considered in using MAD for treatment of OSA.

  8. Profil Merokok pada Pelajar di Tiga SMP di Kota Padang

    Directory of Open Access Journals (Sweden)

    Yessy Susanti Sabti

    2015-09-01

    Full Text Available Abstrak   Merokok merupakan kontributor utama kematian.  Jumlah perokok semakin meningkat di seluruh dunia dan sebagian besar berada dinegara berkembang, termasuk Indonesia. Sebagai negara dengan perokok terbanyak ketiga di dunia, prevalensi perokok remaja di Indonesia semakin meningkat setiap tahun. Dengan menggunakan kuesionerGlobal Youth Tobacco Survey, kami meneliti profil merokok pada pelajar di tida SMP di kota Padang. Desain peneitian adalah crossectional. Data diperoleh dari kuesioner Global Youth Tobacco Survey, berbahasa Indonesia. Didapatkan sampel 240  murid dari 3 SMP dipilih secara acak di Kota Padang. Hasil : 27,7% murid pernah merokok, dan semuanya adalah laki-laki. 29%  mencoba rokok pada usia kurang dari 10 tahun. 37%  murid masih merokok sampai sekarang, 46% diantaranya sudah ketagihan rokok. Sebanyak 77,1% murid yang pernah merokok mempunyai orang tua perokok. Sebagian besar dari total sampel terpapar asap rokok lingkungan baik di rumah dan di tempat-tempat umum. Kesimpulan: Lebih dari seperempat pelajar di tiga SMP di kota Padang pernah merokok dan semuanya laki laki, dan mencoba merokok padausia kurang dari 10 tahun. Hampir seperlima sudah ketagihan merokok.Kata kunci: Pelajar, Merokok, Global Youth Tobacco SurveyAbstract Smoking is the mayor contibutor of death, and the number of smoker is growing overworld. More of them live in the developing country, including Indonesia. As the third of most smoker number, the teenager smoker prevalence in Indonesia is increase over year. By using Indonesian language adapted of Global Youth Tobacco Survey quessionaires, we researched smoking teenager behaviour and realted factors at Junior High School of Padang. Design of study is crossectional, datas collected from 240 students of three randomized selected Junior High School, by  Global Youth Tobacco Survey quessionaires that has adapted to Indonesian language. Results : 27,7% of students reported that they ever smoked cigarettes

  9. I ministri di culto delle confessioni religiose di minoranza: problematiche attuali

    Directory of Open Access Journals (Sweden)

    Matteo Carnì

    2015-06-01

    SOMMARIO: 1. I ministri di culto nell’ordinamento giuridico italiano - 2. I ministri di culto delle confessioni religiose dotate di intesa - 2.1. (segue L’individuazione dei ministri di culto - 2.2. (segue L’assistenza spirituale nelle strutture segreganti - 2.3.(segue Il matrimonio celebrato dai ministri di culto - 2.4 (segue Problematiche attinenti ai ministri di culto buddhisti – 3. I ministri di culto delle confessioni prive di intesa - 3.1. (segue In attesa della legge di approvazione: i ministri di culto della Congregazione cristiana dei Testimoni di Geova - 3.2. (segue Islam e ministri di culto - 4. Osservazioni conclusive.

  10. Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases.

    Science.gov (United States)

    Caldara-Festin, Grace; Jackson, David R; Barajas, Jesus F; Valentic, Timothy R; Patel, Avinash B; Aguilar, Stephanie; Nguyen, MyChi; Vo, Michael; Khanna, Avinash; Sasaki, Eita; Liu, Hung-Wen; Tsai, Shiou-Chuan

    2015-12-15

    Aromatic polyketides make up a large class of natural products with diverse bioactivity. During biosynthesis, linear poly-β-ketone intermediates are regiospecifically cyclized, yielding molecules with defined cyclization patterns that are crucial for polyketide bioactivity. The aromatase/cyclases (ARO/CYCs) are responsible for regiospecific cyclization of bacterial polyketides. The two most common cyclization patterns are C7-C12 and C9-C14 cyclizations. We have previously characterized three monodomain ARO/CYCs: ZhuI, TcmN, and WhiE. The last remaining uncharacterized class of ARO/CYCs is the di-domain ARO/CYCs, which catalyze C7-C12 cyclization and/or aromatization. Di-domain ARO/CYCs can further be separated into two subclasses: "nonreducing" ARO/CYCs, which act on nonreduced poly-β-ketones, and "reducing" ARO/CYCs, which act on cyclized C9 reduced poly-β-ketones. For years, the functional role of each domain in cyclization and aromatization for di-domain ARO/CYCs has remained a mystery. Here we present what is to our knowledge the first structural and functional analysis, along with an in-depth comparison, of the nonreducing (StfQ) and reducing (BexL) di-domain ARO/CYCs. This work completes the structural and functional characterization of mono- and di-domain ARO/CYCs in bacterial type II polyketide synthases and lays the groundwork for engineered biosynthesis of new bioactive polyketides.

  11. DUALISME PENDIDIKAN DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Abdul Wahab

    2013-12-01

    Full Text Available Abstrak: Dalam konteks pendidikan istilah dualisme dan dikotomi memiliki makna yang sama yaitu pemisahan antara pendidikan umum dari pendidikan agama. Dikotomi selalu melahirkan pandangan pembedaaan di satu sisi dan penyamaaan di sisi yang lain. Pandangan dikotomis pada hakikatnya mengabaikan esensi atau nilai sprit pendidikan. Membedakan dan menyamakan lebih dimaknai pada ta-taran permukaan sehingga jelas merusak nilai spirit dari pendidikan Islam. Dua-lisme dan dikotomi bukan hanya pada tataran pemilahan, tetapi telah masuk pada wilayah pemisahan yang dalam operasionalnya memisahkan mata pelajaran umum dari mata pelajaran agama, sekolah umum dan madrasah yang penge-lolaannya berjalan terpisah-pisah. Puncaknya pada pemerintah Orde Baru yang mengeluarkan melalui Surat Keputusan Bersama (SKB pada tanggal 24 Maret 1975 yang menguatkan pemisahan itu hingga saat ini. Dampaknya terasa meru-gikan dan makna Islam menjadi sempit karena pengotak-kotakan ilmu akhirnya menomorduakan dan menganaktirikan pendidikan Islam. Sebagai solusi alter-natif harus diikuti upaya integrasi pengetahuan serta reposisi, yaitu cara pandang yang ilmu-ilmu Islam pada posisi yang sebenarnya. Abstract: In the educational context, the term dualism and dichotomy have the same mea-ning, namely the separation between general education and religious education. The terms also mean the separation between education system of Islamic and ge-neral educations. Moreover, talking about Islamic education is often addressed to Islamic institutions. Such perspectives are triggered by dichotomous view on education, differentiate in one side and equate on the other side. Consequently, the spirit value that is integrated into Islamic education is neglected. The terms, currently, have pervaded on the separation of general and Islamic subjects, public and madrasas Institutions, where the management has a policy respectively. The impacts are narrow minded in interpreting Islamic meaning

  12. EGNOS: è ora di usarlo

    Directory of Open Access Journals (Sweden)

    Fabrizio Bernardini

    2006-04-01

    Full Text Available Dall’inizio di quest’anno EGNOS, European Geostationary Navigation Overlay Service, iniziativa dell’Unione Europea e dell’Agenzia Spaziale Europea, è operativo e nel corso dell’anno raggiungerà i livelli di servizio richiesti dapprima per le applicazioni commerciali e, all’inizio del 2007, quelli per le applicazioni Safety Of Life. Sarà dunque il conseguimento finale di EGNOS V2.1 al quale farà seguito un programma di evoluzione articolato in tre altre fasi che si estenderanno almeno fino alla fine del 2011 con ampliamenti della copertura, della fornitura di servizi anche nella nuovabanda L5, fino all’integrazione con Galileo. In questo articolo,che gode della collaborazione della Next SpA, realizzatriceanche dell’applicazione descritta nella rubrica Reports di questo stesso numero, vogliamo evidenziare alcuni aspetti del sistema che non ci sembra ancora ben apprezzato a livello utente e due prospettive note come SISNET ed ESA ALIVE.

  13. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2002-06-01

    Full Text Available

    Report of PhD dissertation.

    Laura Baietto

    Una politica per le città. Rapporti fra papato, vescovi e comuni nell'Italia centro-settentrionale da Innocenzo III a Gregorio IX, Tesi di dottorato di ricerca in Storia Medievale, Università degli Studi di Torino, 2002

     

    Giuseppe Banfo

    Compresenze e sovrapposizioni di poteri territoriali di qualità diversa tra X e XIII: il caso del basso Monferrato, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Torino, 2002

     

    Francesca Dell'Acqua

    La vetrata tra l'età tardo imperiale e l'altomedioevo: le fonti, l'archeologia, Tesi di Perfezionamento in Storia dell'Arte Medievale, Scuola Normale Superiore di Pisa, 2001

     

    Primo Giovanni Embriaco

    I vescovi di Albenga e gli sviluppi signorili nella Liguria occidentale (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Torino, 2001

     

    Antonella Ghignoli

    Documenti e proprietà altomedievali. Fondamenti e problemi dell'esegesi storica delle fonti documentarie nello specchio della tradizione delle carte pisane dei secoli VIII-XI, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Firenze, 2002

     

    Vito Loré

    Espansione monastica e mutamenti politici. La Trinità di Cava nei suoi rapporti con i sovrani longobardi e normanni e con l'aristocrazia territoriale. Secoli XI-XII, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Firenze, 2002

     

    Rosaria Stracuzzi

    Messina nel '400, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2001

     

    Stefania Tamburini

  14. GAMBARAN PRAKTIK PENGGUNAAN JAMU OLEH DOKTER DI ENAM PROVINSI DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Delima Delima

    2013-02-01

    Full Text Available Abstract Herbal medicine has been widely used. Government supports become more obvious since the declaration of “Saintifikasi Jamu” in Januari 2010 in Kendal, Central Java. To obtain this program, inventory of herbal medicine usage by physicians was conducted. This was a cross sectional descriptive study in 6 provinces of Java and Bali. Doctors registered as member of herbal medicine related association were invited and asked to fill a set of structured questionnaire. A total of 108 physicians using Indonesian herbal medicine participated in this study. They were either general practitioners or specialists with median age of 43 (range 26-70 years old. They (76.9% have used herbal medicine for 1-10 years with median of  2 patients per day (range 0-40. The physicians also practiced other traditional medicines such as acupuncture (47.2 %, massage (7.4 %, acupressure (6.5%. Besides prescribing herbal medicine to their patients, all physicians also consumed herbal medicine for themselves and their family. They used mainly with mono or combined herb in capsule and simplicia. Mostly herbal medicine were given to hypertension, dyslipidemia, diabetes mellitus, acute upper respiratory disease, hepatitis, hyperuricemia, osteoarthritis, diarrhea, cancer, and gastritis. Curcuma xanthorrhiza, Andrographis paniculata, Curcuma domestica (turmeric, Centella asiatica, Orthosiphon aristatus, Apium graveolens (celery, Phylanthus niruri, Guazuma ulmifolia, Zingiber officinale, and Curcuma zedoaria were prescribed. As conclusion, most of the herbal physician in Java and Bali prescribed Indonesian herbal medicine in this 10 years periode combined with foreign herbal medicine and other traditional medicines but still using conventional medicine as the highest standard of theraphy. Key words: herbal medicine, Saintifikasi Jamu, traditional medicine AbstrakPemanfaatan jamu telah berkembang luas. Dukungan pemerintahpun semakin jelas sejak dicanangkannya Saintifikasi

  15. Nuovi strumenti di valutazione funzionale nella distrofia muscolare di Duchenne: Performance of Upper Limb Module per DMD (PUL)

    OpenAIRE

    Lombardo, Maria Elena

    2013-01-01

    Il recente sviluppo di approcci terapeutici per la Distrofia muscolare di Duchenne ha portato alla necessità di identificare nuove misure di valutazione da utilizzare negli studi clinici. Diversi workshop sono stati organizzati per trovare un consenso sulle diverse misure di valutazione clinica da utilizzare, promuovendo la collaborazione di più centri allo scopo di validare gli strumenti di valutazione selezionati.. Le scale di valutazione maggiormente utilizzate nella Distrofia muscolare d...

  16. 40 CFR 721.3130 - Sulfuric acid, mono-C9-11-alkyl esters, sodium salts.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Sulfuric acid, mono-C9-11-alkyl esters... Specific Chemical Substances § 721.3130 Sulfuric acid, mono-C9-11-alkyl esters, sodium salts. (a) Chemical... acid, mono-C9-11-alkyl esters, sodium salts (PMN P-01-149; CAS No. 84501-49-5) is subject to reporting...

  17. Esercizi di relatività generale

    CERN Document Server

    De Felice, Fernando

    2007-01-01

    La teoria della Relatività Generale ha la duplice funzione di descrivere la gravitazione come fenomeno fisico in sé e di fornire al contempo un algoritmo adeguato a descrivere tutte le altre leggi della fisica in presenza di gravitazione, sia essa reale o semplicemente indotta da uno stato di accelerazione. A tale scopo la teoria si presenta con una struttura matematica molto elaborata che richiede come requisito indispensabile conoscenze di geometria differenziale e di calcolo differenziale assoluto. La maggiore difficoltà nell'uso della teoria è riconoscere il legame fra la sua struttura formale e i fenomeni fisici che essa descrive, potendo in tal modo procedere alla loro verificabilità sperimentale. Gli esercizi sono essenziali al raggiungimento di tale obiettivo; lo scopo del libro pertanto è quello di fornire a studenti e cultori della materia una guida all'applicazione dei concetti teorici della Relatività Generale a una vasta gamma di situazioni fisiche.

  18. MAGNESIUM MONO POTASSIUM PHOSPHATE GROUT FOR P-REACTOR VESSEL IN-SITU DECOMISSIONING

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C.; Stefanko, D.

    2011-01-05

    The objective of this report is to document laboratory testing of magnesium mono potassium phosphate grouts for P-Reactor vessel in-situ decommissioning. Magnesium mono potassium phosphate cement-based grout was identified as candidate material for filling (physically stabilizing) the 105-P Reactor vessel (RV) because it is less alkaline than portland cement-based grout (pH of about 12.4). A less alkaline material ({<=} 10.5) was desired to address a potential materials compatibility issue caused by corrosion of aluminum metal in highly alkaline environments such as that encountered in portland cement grouts. Information concerning access points into the P-Reactor vessel and amount of aluminum metal in the vessel is provided elsewhere. Fresh and cured properties were measured for: (1) commercially blended magnesium mono potassium phosphate packaged grouts, (2) commercially available binders blended with inert fillers at SRNL, (3) grouts prepared from technical grade MgO and KH{sub 2}PO{sub 4} and inert fillers (quartz sands, Class F fly ash), and (4) Ceramicrete{reg_sign} magnesium mono potassium phosphate-based grouts prepared at Argonne National Laboratory. Boric acid was evaluated as a set retarder in the magnesium mono potassium phosphate mixes.

  19. [Technique of complex mammary irradiation: Mono-isocentric 3D conformational radiotherapy and helical tomotherapy].

    Science.gov (United States)

    Vandendorpe, B; Guilbert, P; Champagne, C; Antoni, T; Nguyen, T D; Gaillot-Petit, N; Servagi Vernat, S

    2017-12-01

    To evaluate the dosimetric contribution of helical tomotherapy for breast cancers compared with conformal radiotherapy in mono-isocentric technique. For 23 patients, the dosimetric results in mono-isocentric 3D conformational radiotherapy did not satisfy the constraints either of target volumes nor organs at risk. A prospective dosimetric comparison between mono-isocentric 3D conformational radiotherapy and helical tomotherapy was therefore carried out. The use of helical tomotherapy showed a benefit in these 23 patients, with either an improvement in the conformity index or homogeneity, but with an increase in low doses. Of the 23 patients, two had pectus excavatum, five had past thoracic irradiation and two required bilateral irradiation. The other 14 patients had a combination of morphology and/or indication of lymph node irradiation. For these patients, helical tomotherapy was therefore preferred to mono-isocentric 3D conformational radiotherapy. Tomotherapy appears to provide better homogeneity and tumour coverage. This technique of irradiation may be justified in the case of morphological situations such as pectus exavatum and in complex clinical situations. In other cases, conformal radiotherapy in mono-isocentric technique remains to be favoured. Copyright © 2017 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  20. Selective mono-radioiodination and characterization of a cell-penetrating peptide. L-Tyr-maurocalcine

    Energy Technology Data Exchange (ETDEWEB)

    Ahmadi, Mitra; Bacot, Sandrine; Perret, Pascale; Riou, Laurent; Ghezzi, Catherine [Universite Joseph Fourier, Grenoble (France); INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Poillot, Cathy; Cestele, Sandrine [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Desruet, Marie-Dominique [INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Couvet, Morgane; Bourgoin, Sandrine; Seve, Michel [CRI-INSERM U823, Grenoble (France). Inst. of Albert Bonniot; Universite Joseph Fourier, Grenoble (France); Waard, Michel de [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Smartox Biotechnologies, Grenoble (France)

    2014-07-01

    Mono-and poly-iodinated peptides form frequently during radioiodination procedures. However, the formation of a single species in its mono-iodinated form is essential for quantitative studies such as determination of tissue concentration or image quantification. Therefore, the aim of the present study was to define the optimal experimental conditions in order to exclusively obtain the mono-iodinated form of L-maurocalcine (L-MCa). L-MCa is an animal venom toxin which was shown to act as a cell-penetrating peptide. In order to apply the current direct radioiodination technique using oxidative agents including chloramine T, Iodo-Gen {sup registered} or lactoperoxidase, an analogue of this peptide containing a tyrosine residue (Tyr-L-MCa) was synthesized and was shown to fold/oxidize properly. The enzymatic approach using lactoperoxidase/H{sub 2}O{sub 2} was found to be the best method for radioiodination of Tyr-L-MCa. MALDI-TOF mass spectrometry analyses were then used for identification of the chromatographic eluting components of the reaction mixtures. We observed that the production of different radioiodinated species depended upon the reaction conditions. Our results successfully described the experimental conditions of peptide radioiodination allowing the exclusive production of the mono-iodinated form with high radiochemical purity and without the need for a purification step. Mono-radioiodination of L-Tyr-MCa will be crucial for future quantitative studies, investigating the mechanism of cell penetration and in vivo biodistribution.

  1. Steroid sparing effect of sublingual immunotherapy: real life study in mono/polisensitized children with asthma.

    Science.gov (United States)

    Nadir Bahceciler, Nerin; Galip, Nilufer; Babayigit, Arzu

    2017-11-01

    Steroid-sparing effect of sublingual immunotherapy (SLIT) in mono/polisensitized asthmatic children were evaluated.  Children undergoing allergen-specific SLIT between 2010 and 2014 were included. Asthma control and usage/dose of inhaled corticosteroid (ICS) in the previous year was determined. Asthma control without ICS need ≥6 months was defined as 'ICS avoidance'.  90 children (mean ± SD age 8.92 ± 4.17 years) were enrolled, 56.7% (n = 60) being polysensitized. Mono, 2-simultaneous and multiple-pollen-mix allergen SLIT were prescribed in 84.4, 17.8 and 7.8%, respectively. ICS was avoided in 70%, with no significant difference in mono- versus poly-sensitized patients. ICS-avoidance rates in mono-allergen, pollen-mixture and 2-simultaneous-allergen SLIT were 93.6, 83.3 and 73.7%, respectively. Longer-duration SLIT resulted in significantly more ICS-avoidance (p:0.0001). SLIT with mono/multiple-mixed/simultaneous allergens in childhood asthma resulted in retained-avoidance of ICS. Steroid-sparing effect of SLIT in polysensitized children warrants further investigation.

  2. Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach.

    Science.gov (United States)

    Carter-O'Connell, Ian; Jin, Haihong; Morgan, Rory K; Zaja, Roko; David, Larry L; Ahel, Ivan; Cohen, Michael S

    2016-01-26

    ADP-ribosyltransferases (ARTD1-16) have emerged as major downstream effectors of NAD(+) signaling in the cell. Most ARTDs (ARTD7 and 8, 10-12, and 14-17) catalyze the transfer of a single unit of ADP-ribose from NAD(+) to target proteins, a process known as mono-ADP-ribosylation (MARylation). Progress in understanding the cellular functions of MARylation has been limited by the inability to identify the direct targets for individual mono-ARTDs. Here, we engineered mono-ARTDs to use an NAD(+) analog that is orthogonal to wild-type ARTDs. We profiled the MARylomes of ARTD10 and ARTD11 in vitro, identifying isoform-specific targets and revealing a potential role for ARTD11 in nuclear pore complex biology. We found that ARTD11 targeting is dependent on both its regulatory and catalytic domains, which has important implications for how ARTDs recognize their targets. We anticipate that our chemical genetic strategy will be generalizable to all mono-ARTD family members based on the similarity of the mono-ARTD catalytic domains. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  3. Enhancement of low light level images using color-plus-mono dual camera.

    Science.gov (United States)

    Jung, Yong Ju

    2017-05-15

    In digital photography, the improvement of imaging quality in low light shooting is one of the users' needs. Unfortunately, conventional smartphone cameras that use a single, small image sensor cannot provide satisfactory quality in low light level images. A color-plus-mono dual camera that consists of two horizontally separate image sensors, which simultaneously captures both a color and mono image pair of the same scene, could be useful for improving the quality of low light level images. However, an incorrect image fusion between the color and mono image pair could also have negative effects, such as the introduction of severe visual artifacts in the fused images. This paper proposes a selective image fusion technique that applies an adaptive guided filter-based denoising and selective detail transfer to only those pixels deemed reliable with respect to binocular image fusion. We employ a dissimilarity measure and binocular just-noticeable-difference (BJND) analysis to identify unreliable pixels that are likely to cause visual artifacts during image fusion via joint color image denoising and detail transfer from the mono image. By constructing an experimental system of color-plus-mono camera, we demonstrate that the BJND-aware denoising and selective detail transfer is helpful in improving the image quality during low light shooting.

  4. Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach

    Directory of Open Access Journals (Sweden)

    Ian Carter-O’Connell

    2016-01-01

    Full Text Available ADP-ribosyltransferases (ARTD1–16 have emerged as major downstream effectors of NAD+ signaling in the cell. Most ARTDs (ARTD7 and 8, 10–12, and 14–17 catalyze the transfer of a single unit of ADP-ribose from NAD+ to target proteins, a process known as mono-ADP-ribosylation (MARylation. Progress in understanding the cellular functions of MARylation has been limited by the inability to identify the direct targets for individual mono-ARTDs. Here, we engineered mono-ARTDs to use an NAD+ analog that is orthogonal to wild-type ARTDs. We profiled the MARylomes of ARTD10 and ARTD11 in vitro, identifying isoform-specific targets and revealing a potential role for ARTD11 in nuclear pore complex biology. We found that ARTD11 targeting is dependent on both its regulatory and catalytic domains, which has important implications for how ARTDs recognize their targets. We anticipate that our chemical genetic strategy will be generalizable to all mono-ARTD family members based on the similarity of the mono-ARTD catalytic domains.

  5. Calcolo di orbile a mezzo di misura di distanze 2°

    Directory of Open Access Journals (Sweden)

    C. BOTTI

    1976-06-01

    Full Text Available L'autore presenta, in questa nota, un metodo per la
    determinazione di orbite di satelliti attraverso l'elaborazione di sole misure
    di distanza.
    Nella prima parte del lavoro è illustrata la procedura matematica.
    Nella parte successiva sono analizzati i risultati numerici ottenuti
    simulando misure di distanza per diverse configurazioni osservatore-satellite.
    Tali risultati si dimostrano più che soddisfacenti in quanto determinano la
    posizione dell'osservatore e l'orbita del satellite con un errore relativo
    dell'ordine di IO-8.
    SUMMARY. — The author presents, in this note, a method for the determination
    of satellite orbits only through the elaboration of range measurements.
    The mathematical procedure is illustreted in the first part of the paper.
    The numerical results obtained by simulating range measurements of
    several observer-satellite configurations are analyzed in the subsequent part
    of the paper. The results are very satisfactory since the parameters, which
    determine the observer position and the satellite orbit, are obtained with a
    relative error of about 10-8.

  6. BUDIDAYA LOBSTER (Panulirus sp. DI VIETNAM DAN APLIKASINYA DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Akhmad Mustafa

    2013-12-01

    Full Text Available Desa Xuan Tun di Kecamatan Van Ninh Kota Nha Trang Provinsi Khanh Hoa merupakan lokasi pertama kegiatan budidaya lobster di Vietnam yang dilakuan pada tahun 1992. Secara umum di Kota Nha Trang, ada tiga jenis lobster yang dibudidayakan yaitu lobster mutiara (Panulirus ornatus, lobster pasir (Panulirus homarus, dan lobster batik (Panulirus longipes, karena benih lobster tersebut mudah didapat pada awalnya, cepat tumbuh, berukuran besar, warna cerah, dan memiliki harga yang tinggi. Kegiatan budidaya lobster pada dasarnya terdiri atas: penangkapan benih lobster, produksi tokolan lobster, dan pembesaran lobster yang masing-masing merupakan segmen usaha tersendiri. Pakan yang digunakan dalam produksi tokolan dan pembesaran lobster adalah berupa udang, kerang, tiram, cumi-cumi, dan ikan rucah, di mana sebagian besar dari pakan tersebut digunakan ikan rucah terutama pada pembesaran lobster. Sebagai akibat penggunaan pakan tersebut dan peningkatan jumlah keramba jaring apung yang cukup signifikan berdampak pada penurunan kualitas perairan yang memicu berkembangya penyakit susu (milky haemolymph disease sehingga terjadi penurunan produksi. Terkait dengan hasil yang didapatkan tersebut, ke depan diperlukan berbagai kegiatan termasuk untuk dapat diaplikasikan di Indonesia. Kegiatan tersebut meliputi: produksi benih lobster secara buatan di hatcheri dan penggunaan pakan buatan berupa moist pellet. Upaya pencegahan penyakit susu dan perlakuan-perlakuan praktis untuk mencegah perkembangan serangan penyakit susu juga perlu mendapat perhatian. Perkembangan budidaya lobster yang begitu cepat memicu terjadinya penurunan daya dukung lahan. Oleh karena itu, kegiatan untuk menentukan daya dukung lahan dan kesesuaian lahan menjadi penting untuk dilakukan untuk menentukan lokasi dan jumlah keramba jaring apung yang dapat dioperasikan. Penentuan daya dukung lahan dan evaluasi kesesuaian lahan tidak hanya dilakukan pada daerah yang

  7. CHE COSA RESTA DI CHERUBINI OGGI? DUE CASI DI STUDIO

    Directory of Open Access Journals (Sweden)

    Emanuele Miola

    2016-09-01

    Full Text Available A partire dagli anni Duemila, il fenomeno delle cosiddette risorgenze dialettali si è manifestato, nel panorama linguistico italiano, anche attraverso l’emergenza dei dialetti negli ambiti propri della Comunicazione Mediata dal Computer e, specialmente, sui siti internet creati ‘dal basso’, come l’enciclopedia libera e multilingue online Wikipedia. In questo articolo, si esaminerà il lascito di Cherubini e del suo Vocabolario milanese-italiano sull’edizione regionale lombarda della Wikipedia: gli articoli di quest’ultima saranno passati in rassegna, sia dal punto di vista ortografico, comparando le scelte del lessicografo milanese con quelle più in voga online, sia dal punto di vista morfo-sintattico, discutendo in questo secondo caso la presenza e la produttività di alcuni verbi sintagmatici. What remains of Cherubini today? Two case studies Since the beginning of the twenty-first century, the phenomenon of dialect resurgence has manifested in Italy through the emergence of dialects in Computer Mediated Communication, especially, on bottom-up created Web sites, like the free, multilingual, online encyclopedia Wikipedia. In this article, we will examine the legacy of Cherubini and his Milanese-Italian dictionary on the regional Lombard version of Wikipedia. We will review the articles both in terms of spelling, comparing the choices of Milanese lexicographer with those most utilized currently online, and from a morpho-syntactic point of view, discussing the presence and the productivity of some phrasal verbs.

  8. Studio del comportamento di Acanthamoeba. polyphaga in presenza di Legionella pneumophila e di altri batteri ad habitat acquatico

    Directory of Open Access Journals (Sweden)

    M. Bondi

    2003-05-01

    Full Text Available Le amebe a vita libera sono state oggetto di diversi studi negli ultimi anni, non solo per le loro potenzialità patogene nei confronti dell’uomo, ma anche per l’importante ruolo che svolgono in natura, dove agiscono come predatori in grado di controllare le popolazioni batteriche. Alcuni degli organismi fagocitati però possono evitare la lisi fagosomiale e mantenere la loro condizione vitale a livello intracellulare, divenendo endosimbionti. Le amebe fungono così da riserva per questi batteri, proteggendoli da difficili condizioni extracellulari e provvedendo ad un ambiente consono alla loro replicazione. Tale tipo di interazione è particolarmente studiata in Legionella pneumophila, dal momento che l’ampia diffusione di questo germe, nonché la sua virulenza, pare siano fortemente influenzate dalla capacità di parassitare protozoi appartenenti ai generi Acanthamoeba, Naegleria e Balamuthia. Al fine di ottenere maggiori informazioni sui fattori favorenti o inibenti lo sviluppo di questi protozoi, è stato studiato il comportamento di un ceppo di Acanthamoeba polyphaga coltivato, in solido e in liquido, in associazione con L. pneumophila ed altri batteri ad habitat acquatico (Pseudomonas, Aeromonas, Achromobacter, Burkholderia. Su tappeti di cellule batteriche allestiti in Non Nutrient Agar (NNA, A.polyphaga si è mostrata in grado di moltiplicarsi utilizzando come nutrimento tutti i ceppi testati, nonostante alcuni, come Burkholderia cepacia SSV6 e Achromobacter xylox SS28, risultino più idonei al suo sviluppo. In piastre a pozzetti addizionate di acqua condottata autoclavata, il protozoo ha mostrato una buona capacità di sopravvivenza, non risultando inoltre influenzato dalla presenza di legionella o dei batteri acquatici testati. Dal momento che, fra i batteri descritti come capaci di vita intra-amebica, sono inclusi patogeni quali Chlamydia, Legionella, Listeria e Rickettsiae, risulta necessario riconsiderare la rilevanza clinica

  9. Proposal of development of an advanced IORT system; Proposta di sviluppo di un sistema IORT di avanguardia

    Energy Technology Data Exchange (ETDEWEB)

    Ronsivalle, C. [ENEA, Centro Ricerche Frascati, Rome (Italy). Unita tecnico scientifica Tecnologie Fisiche Avanzate; Casali, F. [Bologna Univ., Bologna (Italy), Dipartimento di fisica; Colavita, E. [Calabria Univ., Arcavacata (Italy). Diparimento di fisica; Lamanna, E. [Magna Graecia Univ., Germaneto (Italy). Dipartimento di medicina sperimentale e clinica

    2005-07-15

    In the last years there has been an increasing interest on IORT (Intraoperative Radiation Therapy), also because of the development of dedicated accelerators. This technique represents a very effective oncological treatment consisting in delivering a single high dose on a tumour bed soon after surgery resection. In the following we present the proposal of development of a last generation IORT system based on the use of a linear accelerator with variable energy in the range 3-15 MeV, operating in C band (5712 MHz). Respect to the accelerator used in the commercial IORT systems operating at a typical frequency of 2998 MHz (S band) limited to a maximum energy of 12 MeV, the use of a higher RF frequency allows an increase of the maximum energy. This extends the use of the IORT technique to a wider field of tumors and an improvement of the system in terms of compactness and weight reduction. In addition the machine will be provided with a devoted absolute dosimetry system that will strongly simplify the procedures of dosimetric characterization. We intend to develop the system by a collaboration between ENEA, some Universities (Bologna, Catanzaro and Cosenza) and the national industry. [Italian] Negli ultimi anni si e sviluppato un sempre maggior interesse intorno alla Radioterapia IntraOperatoria (IORT), una particolare tecnica radioterapica che permette di irradiare la zona interessata da un tumore durante un intervento chirurgico utilizzando un fascio di elettroni prodotto da un acceleratore. La diffusione di questa metodica e stata favorita dalla presenza sul mercato di acceleratori installabili direttamente in sala operatoria. Come conseguenza di questa disponibilita sono emerse sia nuove esigenze legate alle particolari applicazioni cliniche, sia richieste di facilita di utilizzo e perfomances sempre piu sofisticate. Viene qui presentata una proposta di sviluppo di un sistema IORT di ultima generazione basato sull'utilizzo di un acceleratore lineare con

  10. Trasforiiazioni Termoelastiche Finite di Solidi Incomprimibili

    Science.gov (United States)

    Signorini, A.

    Queste lezlioni hanno come direttiva una sintesi di quanto si trova sistematicamente sviluppato in una mia Memoria sulle trasformazioni termoelastiche finite di solidi incomprimibili, in corso di stampa negli Annali di Matematica pura e applicata t. XXXIX ( 1955) pp. 147-201 , Verranno anche esposti, come necessaria premessa, alcuni d ei risultati di due precedenti Memorie degli stessi Annali. Invece, per motivo di brevità, non potrò dare neppure un cenno delle ulteriori ricerche svilup pate dal prof. T. Manacorda in tre recentissimi suoi lavori:

  11. Questa è la storia di due ragazzi

    Directory of Open Access Journals (Sweden)

    Maria Lombardo

    2015-07-01

    Full Text Available Questa è la storia di due ragazzi per i quali le speranze di riuscita in una professione artistica come quella dell’attore - già difficile per chiunque - in percentuale erano una su dieci. Forse zero. E invece ce l’hanno fatta: uno a Parigi, l’altro a Roma. Entrambi di colore, entrambi di umili origini, arrivati in Europa come tanti, centinaia di migliaia, nel loro caso non da clandestini. Le storie di Bakary e Federico mostrano come il talento e la fortuna possano vincere le avversità, l’emarginazione, i pregiudizi.

  12. Imago Caesaris argentea. Il busto di Lucio Vero del Tesoro di Marengo

    Directory of Open Access Journals (Sweden)

    Gemma Sena Chiesa

    2008-05-01

    Full Text Available Il prezioso ritratto argenteo di Lucio Vero fu ritrovato a Marengo (Alessandria assieme ad altri argenti spezzati, nascosti e mai più ricuperati, forse frutto di una razzia. Il ritratto rappresenta il principe, raffigurato con corazza e paludamentum, secondo tipo ritrattistico di qualche anno precedente la sua morte. Esso appare come l’esemplare di più elevato livello artistico di una serie di busti imperiali o di grandi personaggi eseguiti in lamina d’argento sbalzata e ritoccata a bulino. Si trattava probabilmente di effigi che dovevano essere poste in luoghi pubblici, come tribunali o sedi di funzionari imperiali, o negli accampamenti militari a rappresentare il potere e la maestà del principe. Alcuni ritratti argentei erano anche dedicati da singoli funzionari o personaggi autorevoli o dai membri di un collegium in occasione di celebrazioni imperiali.

  13. Studio di prototipo di calorimetro per neutroni per l'esperimento ALICE

    CERN Document Server

    Arnaldi, R; Cicalò, C; Cortese, P; De Falco, A; Dellacasa, G; De Marco, N; Gallio, M; Macciotta, P; Masoni, A; Musso, A; Oppedisano, C; Piccotti, A; Puddu, G; Scomparin, E; Siddi, S; Serci, E; Soave, C; Usai, G L; Vercellin, Ermanno

    1999-01-01

    ALICE e uno dei quattro esperimenti previsti ad LHC, al CERN, il cui scopo e lo studio delle osservabili che danno informazioni rilevanti sulla formazione del quark gluon plasma, che potrebbe essere prodotto in collisioni centrali Pb-Pb, di energia nel centro di massa di 5.5 A TeV.Il parametro di impatto di tali collisioni verra determinato grazie ad un insieme di calorimetri per protoni e neutroni che misureranno l'energia portata in avanti dai nucleoni non interagenti(spettatori).E' stato costruito un prototipo di calometro per neutroni, formato da piani di fibre di quarzo, posti a 45 gradi rispetto all'asse del fascio e inframmezzati da piani di materiale passivo denso(tungsteno). La luce Cerenkov prodotta nelle fibre dallo sciame sviluppato nel materiale passivo,viene raccolta da guide ottiche in aria.Verranno presentati i rilustati di un test previsto al CERN SPS per il luglio 1999.

  14. Impact of temperature on performance of series and parallel connected mono-crystalline silicon solar cells

    Directory of Open Access Journals (Sweden)

    Subhash Chander

    2015-11-01

    Full Text Available This paper presents a study on impact of temperature on the performance of series and parallel connected mono-crystalline silicon (mono-Si solar cell employing solar simulator. The experiment was carried out at constant light intensity 550 W/m2with cell temperature in the range 25–60 oC for single, series and parallel connected mono-Si solar cells. The performance parameters like open circuit voltage, maximum power, fill factor and efficiency are found to decrease with cell temperature while the short circuit current is observed to increase. The experimental results reveal that silicon solar cells connected in series and parallel combinations follow the Kirchhoff’s laws and the temperature has a significant effect on the performance parameters of solar cell.

  15. Second- and third-order nonlinear optical properties of unsubstituted and mono-substituted chalcones

    Science.gov (United States)

    Abegão, Luis M. G.; Fonseca, Ruben D.; Santos, Francisco A.; Souza, Gabriela B.; Barreiros, André Luis B. S.; Barreiros, Marizeth L.; Alencar, M. A. R. C.; Mendonça, Cleber R.; Silva, Daniel L.; De Boni, Leonardo; Rodrigues, J. J.

    2016-03-01

    This work describes the second and third orders of nonlinear optics properties of unsubstituted chalcone (C15H12O) and mono-substituted chalcone (C16H14O2) in solution, using hyper-Rayleigh scattering and Z-Scan techniques to determine the first molecular hyperpolarizability (β) and the two-photon absorption (2PA) cross section respectively. β Values of 25.4 × 10-30 esu and 31.6 × 10-30 esu, for unsubstituted and mono-substituted chalcone, respectively, dissolved in methanol have been obtained. The highest values of 2PA cross-sections obtained were 9 GM and 14 GM for unsubstituted and mono-substituted chalcone, respectively. The experimental 2PA cross sections obtained for each chalcone are in good agreement with theoretical results.

  16. Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination

    Science.gov (United States)

    Xie, Feng; Zhang, Zhengkui; van Dam, Hans; Zhang, Long; Zhou, Fangfang

    2014-01-01

    TGF-β(transforming growth factor-β) superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals are transduced by transmembrane type I and type II serine/threonine kinase receptors and their downstream effectors, the SMAD (drosophila mothers against decapentaplegic protein) proteins. Numerous studies have already demonstrated crucial regulatory roles for modification of TGF-β pathway components by poly-ubiquitination. Recently, several studies also uncovered mono-ubiquitination of SMADs as a mechanism for SMAD activation or inactivation. Mono-ubiquitination and subsequent deubiquitination of SMAD proteins accordingly play important roles in the control of TGF-β superfamily signaling. This review highlights the major pathways regulated by SMAD mono-ubiquitination. PMID:25317929

  17. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-12-01

    Full Text Available Report of PhD Dissertations.Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2003   Marco Meschini, Innocenzo III e il "negotium pacis et fidei" in Linguadoca tra il 1198 e il 1215, Tesi di dottorato di ricerca in Storia medievale, Università Cattolica del Sacro Cuore, 2003   Fabrizio Ricciardelli The Politics of Exclusion in Florence (1215-1434, thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in History, University of Warwick, Department of History, April 2003 Renata Salvarani Baptizare pueros et decimas dare. Cura delle anime, strutturazione ecclesiastica e organizzazione delle campagne in area gardesana fra VIII e XIII secolo (diocesi di Brescia, Verona, Mantova e Trento, Tesi di dottorato in Storia medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2002-2003   Vito Sibilio Le parole della prima crociata, Tesi di dottorato di ricerca in Storia dei centri delle vie e della cultura dei pellegrinaggi nel medioevo euromediterraneo, Università degli studi di Lecce, 2003Segnalazione di tesi di dottorato. Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV

  18. Diferensi Makna Kurikulum Di Indonesia

    Directory of Open Access Journals (Sweden)

    Ismail Muhammad

    2017-09-01

    Full Text Available In Indonesia, the curriculum is understood in accordance with the Act mentioned in the National Education System in the top ie, a set of plans and arrangements regarding the purpose, content, and teaching materials, as well as the methods used to guide the organization of learning activities to achieve specific educational goals. Here explicitly can be observed that the anatomy curriculum in Indonesia contains three aspects, namely: learning objectives, learning materials, and methods. Then some of the experts whom Hilda Taba, Nana Syaodih Sukmadinata and Oemar Hamalik add evaluation component as an important component of the curriculum, because the evaluation is considered as an inseparable part of the curriculum. Di Indonesia kurikulum dipahami sesuai dengan yang disebutkan dalam Undang-undang Sistem Pendidikan Nasional di atas yaitu, seperangkat rencana dan pengaturan mengenai tujuan, isi, dan bahan pelajaran, serta cara yang digunakan sebagai pedoman penyelenggaraan kegiatan pembelajaran untuk mencapai tujuan pendidikan tertentu. Di sini secara eksplisit dapat diamati bahwa anatomi kurikulum di Indonesia mengandung tiga aspek, yaitu: tujuan pembelajaran, materi pembelajaran, dan metode. Kemudian beberapa para ahli di antaranya Hilda Taba, Nana Syaodih Sukmadinata dan Oemar Hamalik menambah komponen evaluasi sebagai komponen penting kurikulum, karena evaluasi dianggap sebagai bagian yang tidak dapat dipisahkan dari kurikulum.

  19. Problemi di traduzione della Politica di AristoteleIl caso della traduzione in francese di Nicole Oresme

    Directory of Open Access Journals (Sweden)

    Claudio Fiocchi

    2008-07-01

    Full Text Available Necessità pratiche e riflessioni teoriche accompagnano il lavoro di Oresme, nella consapevolezza che la traduzione delle grandi opere è uno strumento fondamentale per la grandezza di un popolo.

  20. Imaging the magmatic system of Mono Basin, California with magnetotellurics in three--dimensions

    Science.gov (United States)

    Peacock, Jared R.; Mangan, Margaret T.; McPhee, Darcy K.; Ponce, David A.

    2015-01-01

    A three–dimensional (3D) electrical resistivity model of Mono Basin in eastern California unveils a complex subsurface filled with zones of partial melt, fluid–filled fracture networks, cold plutons, and regional faults. In 2013, 62 broadband magnetotelluric (MT) stations were collected in an array around southeastern Mono Basin from which a 3D electrical resistivity model was created with a resolvable depth of 35 km. Multiple robust electrical resistivity features were found that correlate with existing geophysical observations. The most robust features are two 300 ± 50 km3 near-vertical conductive bodies (3–10 Ω·m) that underlie the southeast and north-eastern margin of Mono Craters below 10 km depth. These features are interpreted as magmatic crystal–melt mush zones of 15 ± 5% interstitial melt surrounded by hydrothermal fluids and are likely sources for Holocene eruptions. Two conductive east–dipping structures appear to connect each magma source region to the surface. A conductive arc–like structure (resistivity (200 Ω·m) suggestive of a cooled connection. A third, less constrained conductive feature (4–10 Ω·m) 15 km deep extending to 35 km is located west of Mono Craters near the eastern front of the Sierra Nevada escarpment, and is coincident with a zone of sporadic, long–period earthquakes that are characteristic of a fluid-filled (magmatic or metamorphic) fracture network. A resistive feature (103–105 Ω·m) located under Aeolian Buttes contains a deep root down to 25 km. The eastern edge of this resistor appears to structurally control the arcuate shape of Mono Craters. These observations have been combined to form a new conceptual model of the magmatic system beneath Mono Craters to a depth of 30 km.

  1. Sirio Giannini, Prati di fieno e I racconti

    Directory of Open Access Journals (Sweden)

    Arianna Gianotti

    2010-06-01

    Full Text Available Recensiamo i due volumi di Sirio Giannini, Prati di fieno, con Prefazione di Daniela Marcheschi, e I racconti, con Prefazione di Paolo Capovani, Edizioni Polistampa, Firenze, 2010.

  2. I funerali di Carlo III nella cattedrale di Palermo

    Directory of Open Access Journals (Sweden)

    Giuseppina Leone

    2000-01-01

    Full Text Available Nel 1789 in occasione del funerale di Cario Ili re delle Spagne e dell'Infante di Napoli, D. Gennaro Borbone viene pubblicato a Palermo a cura della Reale Stamperia un interessante volume che illustra le cerimonie svolte in tale occasione nonché il progetto effimero elaborato per la navata principale della cattedrale di Palermo. L'architetto incaricato per il progetto è il sacerdote ingegnere Salvatore Attinelli. Motivo di sorprendente interesse è il fatto che l'Intervento si colloca in un cantiere aperto. Infatti, ventidue anni prima, nel 1767, era stato commissionato dall'arcivescovo Serafino Filangeri un progetto a Ferdinando Fuga per il totale rinnovamento della prestigiosa fabbrica palermitana. Il progetto effimero proposto da Attinelli (che lavora da anni nel cantiere della cattedrale sembra costituire pretesto per un ultimo tentativo di revisione del progetto in corso di cantiere. Sembra cioè collocarsi sulla scia delle polemiche nei confronti del progetto del Fuga, che aveva ricevuto tante critiche da dover essere sottoposto all'approvazione reale. Lo studio di questo apparato effimero offre dunque uno spunto di riflessione sulle cerimonie funebri che venivano colte come occasione per modificare le scelte architettoniche intraprese.In 1789 on occasion of the funerais of Carlo III, king of Spain, and of the Infante of Naples, D. Gennaro Borbone, it was published in Palermo by the Royal Printing-house an interesting volume illustrating the ceremonies which have been carried out in this event, as well as the ephemeral project elaborated for the nave of Palermo cathedral. The architect uncharged of the project was Salvatore Attinelli a priest engineer. It's ground of surprising interest the fact that this happened while the building was in construction. As matter of fact, twenty-two years before, in 1767, a project had been ordered to Ferdinando Fuga by the archbishop Serafino Filangeri for a complete renewal of the prestigious building

  3. Elementi di management dei programmi spaziali

    CERN Document Server

    Spagnulo, Marcello

    2012-01-01

    La realizzazione e il lancio nello spazio di satelliti o sonde attraverso missili o navette spaziali sono un esempio di attività industriale di enorme complessità e di lungo periodo. Lo sviluppo di un programma spaziale prevede la realizzazione di vari sistemi costituenti: il segmento spaziale, cioè i lanciatori per l’accesso allo Spazio, i satelliti o le sonde, le infrastrutture spaziali abitate da astronauti oppure robotizzate; e il segmento di terra che consente agli operatori sulla terra di controllare i sistemi nello spazio e di fruire delle applicazioni derivanti dal loro uso. Il settore è di per sé peculiare dato l’ambiente extra-atmosferico ove si troveranno ad operare astronauti o sonde robotizzate, pertanto la manifattura dei sistemi spaziali è una pratica a metà strada tra la scienza esatta e l’artigianato di elevatissima qualità. Le metodologie e i processi realizzativi dei programmi spaziali hanno però avuto il pregio nel passato di costituire, sin dagli anni ’60, un modello di r...

  4. Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes

    OpenAIRE

    Wang, Bei; Suzuki, Hiroyuki; Kato, Mitsuyasu

    2008-01-01

    TGF-β activates receptor-regulated Smad (R-Smad) through phosphorylation by type I receptors. Activated R-Smad binds to Smad4 and the complex translocates into the nucleus and stimulates the transcription of target genes through association with co-activators including p300. It is not clear, however, how activated Smad complexes are removed from target genes. In this study, we show that TGF-β enhances the mono-ubiquitination of Smad4. Smad4 mono-ubiquitination was promoted by p300 and suppres...

  5. Permethylated metallocenes as suitable models for obtaining the onium mono- and dications

    International Nuclear Information System (INIS)

    Rybinskaya, M.I.; Krejndlin, A.Z.; Khoffmann, R.; Minyaev, R.M.

    1994-01-01

    Permethylated metallocenes of iron sub-group (M = Fe, Ru, Os) have been considered as suitable models for obtaining the onium mono- and dications. EHM MO calculation of charge distribution in monocations, homoannular and heteroannular dications has shown that the positive charge is localized mainly at the metal atom. This fact was confirmed by X-ray studies, IR, 1 H and 13 C NMR spectral and electrochemical data. Reactivity of monocations has been studied. It is shown that M-C(α) σ-bond is realized in mono- and dications under investigation. 36 refs.; 3 tabs

  6. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

    Directory of Open Access Journals (Sweden)

    Giovanna Bosica

    2016-06-01

    Full Text Available Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

  7. Endospores of B subtilis are pyrogenic and activate Mono Mac 6 cells

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, Erik W; Christensen, Jens D

    2003-01-01

    The monocytic cell line Mono Mac 6 is sensitive to pyrogens and interleukin-6 secretion is induced after exposure to pyrogens. The aim of this study is to examine the pyrogenic activity and the interleukin-6-inducing capacity of the Gram-positive B. subtilis bacteria, endospores and isolated cell...... wall components. Furthermore the involvement of CD14 in activation of interleukin-6 release is investigated. All test substances are pyrogenic in the rabbit pyrogen test. The test substance is incubated with monocytic cells (Mono Mac 6) for 24 h and the secreted interleukin-6 is determined...

  8. Forced vibration and wave propagation in mono-coupled periodic structures

    DEFF Research Database (Denmark)

    Ohlrich, Mogens

    1986-01-01

    This paper describes the wave propagation and vibration characteristics of mono-coupled structures which are of spatially periodic nature. The receptance approach to periodic structure theory is applied to study undamped periodic systems with composite structural elements; particular emphasis...... is laid on investigating resonant periodic point loading and its pronounced effect on the propagation of longitudinal waves. General mono-coupled periodic systems are first assumed to be infinite in extent; thereafter reflections caused by arbitrary end terminations of finite structures are considered...

  9. Mono- and Bis(pyrrolo)tetrathiafulvalene Derivatives Tethered to C60

    DEFF Research Database (Denmark)

    Solano, Marta Vico; Della Pia, E. A.; Jevric, M.

    2014-01-01

    A series of mono- (MPTTF) and bis(pyrrolo) tetrathiafulvalene (BPTTF) derivatives tethered to one or two C-60 moieties was synthesized and characterized. The synthetic strategy for these dumbbell-shaped compounds was based on a 1,3-dipolar cycloaddition reaction between aldehyde-functionalized MP......A series of mono- (MPTTF) and bis(pyrrolo) tetrathiafulvalene (BPTTF) derivatives tethered to one or two C-60 moieties was synthesized and characterized. The synthetic strategy for these dumbbell-shaped compounds was based on a 1,3-dipolar cycloaddition reaction between aldehyde...

  10. Fisica del nucleo stelle di neutroni

    CERN Document Server

    Bernardini, Carlo

    1982-01-01

    Studio sistematico delle masse nucleari ; energia di legame ; raggi nucleari dai nuclei speculari ; il nucleo in approssimazione di Thomas-Fermi ; introduzione allo scattering : caratterizzazione cinematica degli urti ; la sezione d'urto ; il fattore di forma dei nuclei ; gli atomi u-mesici ; proprieta elettromagnetiche statiche dei nuclei (momenti di multipolo) ; momento di quadrupolo elettrico dei nuclei ; momento d dipolo magnetico dei nuclei ; metodo delle risonanze magnetiche nucleari (NMR) ; misura del fattore giromagnetico e del momento di quadrupolo ; modelli nucleari a particelle indipendenti, il modello a shell ; l'interazione spin-orbita ; il modello a shell e le linee di Schmidt per il momento magnetico dei nuclei con "A" dispari ; nuclei non sferici (deformati) ; stelle di neutroni.

  11. SEBARAN JENIS-JENIS MANGIFERA DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Ruddy Polosakan

    2016-01-01

    Full Text Available Marga Mangifera merupakan salah satu marga dari suku Anacardiaceae yang cukup penting di Indonesia. Hal ini disebabkan beberapa jenisnya merupakan sumber buah-buahan tropis andalan. Di Indonesia terdapat 19 jenis dari marga Mangifera yang tersebar di seluruh kawasan Indonesia. Beberapa diantaranya merupakan jenis-jenis endemik. Sebaran jenis Mangifera yang terbanyak berada di Kalimantan (12 jenis,Sumatera (13 jenis dan Jawa (7 jenis sedangkan yang terendah di Papua (1 jenis. Mangifera umumnya tersebar di kawasan hutan dataran rendah (0‒1000 m dpl, baik hutan primer maupun sekunder. Berdasarkan habitatnya sebaran terbanyak berada di hutan pedataran lahan kering, namun beberapa jenis antara lain Mangifera quadrifida, M. gedebe, M. parvifolia, M. havilandii dan M. caesia mampu hidup di rawa-rawa dan tepi sungai.

  12. FOTOGRAFIA DI STRUMENTI MUSICALI METODO DI DOCUMENTAZIONE QUOTIDIANO E PROVE ELEMENTARI DI FILOLOGIA DIGITALE

    Directory of Open Access Journals (Sweden)

    Emanuele Marconi

    2012-04-01

    Full Text Available

    Il restauro virtuale, inteso come manipolazione 2d di un’immagine attraversoprogrammi di grafi ca o elaborazione digitale, può essere, in alcuni casi, unvalido aiuto per la ricerca ontologica per ottenere una visione di insieme diun'opera prima di un intervento di restauro o per ricostruire parti che non sonopervenute. In alcuni casi la manipolazione dell’immagine diviene un supporto perla ricerca organologica.

     

    Digital photo of musical instruments

    Digital photography is a great support in musical instruments conservation forms filling. Video documentation, still not much used, contributes a great amount of details that doesn’t written text or still images. Digital image manipulation,or virtual restoration (defined as the manipulation of 2D image through digital imaging processing, in some cases can be a great help to get a fi rst overview of a restoration, or to reconstruct parts of an artwork that are missed. Some case studies are presented, showing differents application ofsimple techniques to on the field activities regarding musical instruments.

  13. Coming to terms with our colonial past: Regina di fiori e di perle by ...

    African Journals Online (AJOL)

    Il romanzo Regina di fiori e di perle (2007) di Gabriella Ghermandi presenta due filoni narrativi: quello nel quale vengono raccolti oralmente i racconti dei testimoni degli anni coloniali sotto il fascismo, e quello del bildungsroman, nel quale il personaggio principale, Mahlet, cresce e si rende conto del proprio destino di ...

  14. Trasformare luoghi di guerra in luoghi di pace: Appeace: War Places/Peace Citizens

    Directory of Open Access Journals (Sweden)

    Elisa Gardini

    2015-07-01

    Full Text Available Il progetto triennale Appeace: War Places/Peace Citizens è partito da Montescudo, nell'entroterra riminese, con l’intento di trasformare una rete europea di luoghi di guerra, feriti dal passaggio dei conflitti bellici del Novecento, in una memoria condivisa e improntata a una cultura di pace.

  15. L'interaction design come strumento di ricerca antropologica: the crossing project di Ranjit Makkuni

    Directory of Open Access Journals (Sweden)

    Luca Simeone

    2003-09-01

    Full Text Available Alcune pratiche innovative di interaction design possono rappresentare un prezioso strumento di ricerca antropologica. Ne è un esempio l'opera di Ranjit Makkuni, un interaction designer indiano, che crea prototipi di media digitali che coniugano tecnologia e riscoperta delle tradizioni culturali locali.

  16. ANTROPOLOGIA DI UN INTELLETTUALE, GIUSEPPE CASSIERI

    African Journals Online (AJOL)

    sogni, a discapito di una attività e creatività mentale che viene inibita nei livelli più profondi. “Il trio canonico di memoria, tradizione ed identità”. (106) viene ad essere messo in discussione dallo stesso Cassieri perché laddove in Saverio Lamanna diventa causa di scomodo, in molti pensatori oggi è motivo solo di visibilità.

  17. Principi generali di gestione della manutenzione

    CERN Document Server

    Furlanetto, Luciano; Macchi, Marco

    2006-01-01

    In questo volume vengono fornite le premesse per il superamento della tradizionale visione della manutenzione, quale inevitabile accidente e costo da ridurre, a favore di un'immagine culturale innovativa in cui la manutenzione consente un superamento del modello consumistico delle sostituzioni verso una ecosostenibilità del patrimonio di impianti e infrastrutture. Sulla base di queste premesse, ci si rivolge a manager, imprese, studiosi e studenti del campo dei servizi di manuntenzione.

  18. Transesterificación de ésteres grasos con arilaminoalcoholes. Síntesis de mono- y diacilderivados del 3-fenilamino-1,2-propanodiol

    Directory of Open Access Journals (Sweden)

    Gómez Gómez, R.

    1991-10-01

    Full Text Available In this paper the synthesis of acylderivatives of 3-phenylamino- 1,2 propanediol has been studied. These compounds are prepared by transesterification of fatty acids methyl esters with the amino-alcohol and sodium methoxide as catalyst. The reaction was carried out with mechanical stirring under vacuum. The effect of temperature, molar relation of reactives, time and concentration of catalyst on the reaction yield has been investigated. Yield increases with temperature and ester concentration until the optimun reaction temperature is reached. This temperature depend on molar relation ester/aminoalcohol (140 °C for 1/1 and 2/1 values and 120 °C for 4/1 value. The composition of reaction mixture was evaluated from the mono/di relation. This relation decrease when temperature and molar relation increase.

    En el presente trabajo se ha abordado la síntesis de los acilderivados del 3-fenilamino-1,2-propanodiol por transesterificación de ésteres metílicos de ácidos grasos con 3-fenilamino- 1,2-propanodiol utilizando metóxido sódico como catalizador. La reacción se lleva a cabo bajo presión reducida y agitación mecánica. Se ha estudiado la influencia de la temperatura, relación molar de los reactivos, tiempo y concentración de catalizador sobre el rendimiento de la reacción. El rendimiento aumenta con la temperatura y la concentración de éster hasta alcanzar la temperatura óptima de reacción. Esta temperatura depende de la relación molar y es de 140 °C para las relaciones molares éster: 3-fenilamino-1,2-propanodiol (1:1 y (2:1 y de 120 °C para (4:1. La composición de la mezcla de reacción se evalúa mediante la relación mono-/di-. Esta relación disminuye conforme aumenta la temperatura y la relación molar.

  19. 21 CFR 582.4505 - Mono- and diglycerides of edible fats or oils, or edible fat-forming acids.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Mono- and diglycerides of edible fats or oils, or edible fat-forming acids. 582.4505 Section 582.4505 Food and Drugs FOOD AND DRUG ADMINISTRATION... edible fat-forming acids. (a) Product. Mono- and diglycerides of edible fats or oils, or edible fat...

  20. Uno strumento per la creazione di valore nella realizzazione di edifici sostenibili: la certificazione LEED

    Directory of Open Access Journals (Sweden)

    S. Rick Fedrizzi

    2014-06-01

    Full Text Available Il presente lavoro ha l’obiettivo di delineare gli aspetti chiave della sostenibilità in ambito edilizio focalizzando l’attenzione sul sistema di certificazione LEED® quale strumento “universale” di supporto per la realizzazione, gestione e valutazione di edifici sostenibili. Nella prima parte del lavoro si descrive la rapida diffusione della certificazione LEED nel recente passato quale diretta conseguenza della capacità di questo strumento di rating di adattarsi sia alle specifiche tipologie di edifici, sia alle diversità climatiche e morfologiche dei siti. Nella seconda parte si procede invece a presentare ed analizzare gli aspetti economico-finanziari degli edifici sostenibili con riferimento sia alle metodologie valutative applicabili, sia ai dati della letteratura. Partendo dalle esperienze internazionali in tema di sostenibilità, si procede successivamente a descrivere la situazione italiana, evidenziando la percezione del mercato e le opportunità di sviluppo future.

  1. Prezzi di Offerta vs Prezzi di Mercato: un’analisi empirica

    Directory of Open Access Journals (Sweden)

    Rocco Curto

    2012-06-01

    Full Text Available Il problema della trasparenza del mercato immobiliare in Italia implica che molte analisi debbano essere fatte utilizzando i prezzi di offerta e che questi ultimi siano anche utilizzati dagli operatori del settore a fini estimativi. Nonostante l’importanza dei prezzi di offerta per l’interpretazione del mercato sia riconosciuta anche nella letteratura internazionale, si ritiene opportuno approfondire la loro relazione con i prezzi di transazione. A tal fine, in questo scritto si propone una metodologia di analisi che permetta di testare se e in quale misura i prezzi di offerta possano essere considerati una proxy per i prezzi di mercato. In particolare modo si vuole testare se la variabilità dei prezzi di offerta possa essere un riferimento per le analisi di variabilità sul mercato immobiliare. Il modello viene testato empiricamente su un caso studio: il mercato immobiliare di Torino ed i sottomercati geografici che lo compongono.

  2. Eredità della tradizione classica nei mosaici parietali di V e VI secolo: problematiche di iconografia e di stile

    Directory of Open Access Journals (Sweden)

    Letizia Sotira

    2012-02-01

    Full Text Available Fin dal III secolo l’arte cristiana, come testimoniano le pitture catacombali, appare fortemente radicata in un tessuto iconografico e stilistico di sostanza classica, innestandosi costantemente soprattutto sulle tematiche celebrative proprie dell’iconografia aulica, nutrendosi profondamente di esse e generando una nuova linfa ideologica e spirituale. Nell’ambito della decorazione musiva parietale, ciò è evidente in diversi temi iconografici quali l’offerta della corona che riprende il modello imperiale romano dell’aureum coronarium offerto dai vinti all’imperatore; i re magi che nella loro gestualità richiamano la sottomissione dei re barbari all’imperatore; l’acclamatio degli Apostoli che alzano solennemente la mano destra come dignitari che acclamano l’imperatore vittorioso; Cristo nell’atto di calpestare i saeva crimina; la corona di alloro come simbolo di vittoria; le imagines clipeatae contenenti i busti di santi e sante, che ci riportano alla ritrattistica romana di epoca tardo-repubblicana, o ancora le finte architetture del secondo registro della decorazione musiva della cupola del Battistero degli Ortodossi a Ravenna, e quelle della Rotonda di San Giorgio a Salonicco, che si collocano entrambe sulla strada dell’illusionismo ellenistico, ricordando gli affreschi pompeiani. Proprio attraverso la disamina di queste e di altre illuminanti immagini, nel mio articolo intendo affrontare e approfondire le problematiche legate alla continuità della tradizione classica nei mosaici parietali di V e VI secolo di Ravenna e dell’area bizantina, sia dal punto di vista iconografico che stilistico: ciò sulla scia degli autorevoli studi di Beat Brenk e di Ernst Kitzinger che portarono avanti un interessante dibattito scientifico su tali argomenti.

  3. La ragione flessibile di Giovanni Bottiroli

    Directory of Open Access Journals (Sweden)

    Elio Franzini

    2013-12-01

    Full Text Available Recensione a Giovanni Bottiroli, La ragione flessibile. Modi d’essere e stili di pensiero. Torino: Bollati Boringhieri, 2013. Sulla possibilità di una «logica della flessibilità» (Bottiroli ovvero di una «logica che segua la vita» (Franzini.

  4. LI PIRANDELLISMO DI BUZZATI (Prima Parte)

    African Journals Online (AJOL)

    User

    N. Bonifazi, Teoria del fantastico e il racconto fantastico in Italia: Tarchetti - Pirandello - ... È la scena in cui si raffigura la camera del protagonista Giovanni Drogo che viene tenuta sempre pronta dalla madre: Drogo si voltò a guardare la città contro .... l'abilità di recitare, di fingere, di falsificare, che mente per nascondere.

  5. Lezioni di fisica teorica meccanica quantistica

    CERN Document Server

    Verde, Mario

    Ottica geometrica ed ottica ondulatoria ; risoluzion spettrale di Fourier ; meccanica classica e meccanica ondulatoria ; esempi di alcuni moti semplici in meccanica ondulatoria ; operatori lineari e loro rappresentazioni ; formulazione più generale della nuova meccanica ; costanti del movimento ; l'atomo di Idrogeno ; teoria delle perturbazioni.

  6. Uso dello spazio da parte dello scoiattolo comune (Sciurus vulgaris in bosco di conifere

    Directory of Open Access Journals (Sweden)

    M. Adamo

    2003-10-01

    Full Text Available Nell?ambito di un progetto di ricerca sull?ecologia dello scoiattolo comune in boschi di conifere delle Alpi, abbiamo avviato uno studio con la radiotelemetria per indagare i fattori che influiscono sull?uso dello spazio da parte degli animali. I risultati riportati nel presente lavoro si riferiscono a due anni successivi caratterizzati da una diversa disponibilità alimentare. L?area di studio si trovava nel Parco Nazionale del Gran Paradiso, in Val di Rhemes, all?interno di una pecceta subalpina (Picea abies 85%, Larix decidua 11%, alberi morti 4%. La produzione energetica del bosco (semi delle conifere è stata valutata moltiplicando il n. di piante per ettaro x il n. medio di coni prodotti (contati su 60 alberi campione x il n. medio di semi per cono x il peso medio dei semi, trasformando poi la biomassa in Mj. Le catture sono state effettuate tre volte l?anno nel 2001 e 2002 con 30 trappole incruente Tomahawk tipo 201. Diciotto scoiattoli nel 2001 e 13 nel 2002 sono stati dotati di radiocollare (PD-2C Holohil Systems Ltd. e seguiti in estate e autunno. Sono stati calcolati i seguenti parametri: home range MCP 100%, MCP 95% (animali con singole escursioni, 100% Cluster-based (animali che usavano differenti aree di attività; stime delle core-area mono e multinucleari effettuate con la tecnica della Cluster Analysis 85%; sovrapposizione delle core-area. Nel 2001, all?inizio dell?estate, 4 maschi su 8 e 7 femmine su 8 sono emigrati nella valle adiacente o a quote più basse. Nel 2002, tutti gli individui sono rimasti residenti. La dimensione media degli home range stagionali nel 2001 è stata di 83,30 ± 48,72 ha (n = 30 contro 31,04 ± 16,65 ha (n = 19 nel 2002, la media delle core-area è stata 18,18 ± 17,74 ha nel 2001 e 9,36 ± 5,40 ha in 2002 (Kruskal-Wallis ANOVA: home range H = 22,6; g.l. = 1, P < 0,0001; core-area H = 4,55, g.l. = 1, P = 0,033. La sovrapposizione delle core-area maschio/femmina e femmina/maschio

  7. TINGKAT KEMATANGAN MANAJEMEN PROYEK: SURVEI DI BEBERAPA TEMPAT DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Achmad Fuad Bay

    2005-01-01

    Full Text Available This paper presents the results of a pilot survey aimed at ascertaining the level of project management maturity in Indonesian companies. Kerzner’s Level 2 assessment tool was used, which basically assesses maturity levels throughout the various phases of an organization’s project management life cycle. This study compare maturity of current situation and expectation of 70 respondents working in 6 different types of organizations in Indonesia. Differences were identified between types of organisations, with the Financial Institutions, Consultants and Manufacturers belonging to a group with higher current maturity scores, while Consultants, Manufacturers and Service Providers belonging to a group with higher expected future maturity scores. There were no significant differences between the results for the various stages of the project life cycle. The results indirectly confirm that the organisations of the participants of the survey are less effective/excellent than they could be. Abstract in Bahasa Indonesia : Makalah ini menyajikan hasil survei awal yang bertujuan untuk menentukan tingkat kematangan perusahaan-perusahaan di Indonesia dalam menggunakan metodologi manajemen proyek. Alat ukur yang digunakan adalah Kerzner Tingkat 2, yang mengukur tingkat kematangan melalui berbagai tahapan dari siklus manajemen proyek sebuah organisasi. Studi ini membandingkan tingkat kematangan saat ini dan harapan di masa mendatang terhadap 70 responden yang bekerja di enam jenis organisasi di Indonesia. Hasil survei menunjukkan adanya perbedaan antara berbagai jenis organisasi. Institusi financial, konsultan dan industri barang termasuk dalam kelompok yang nilai kematangannya lebih tinggi untuk kondisi saat ini, sedangkan konsultan, industri barang dan industri jasa termasuk kelompok yang mengharapkan kematangan lebih tinggi di masa mendatang. Tidak ada perbedaan yang signifikan antara tingkat kematangan pada berbagai tahapan pada siklus proyek. Hasil

  8. La gestione dei flussi turistici tramite sistemi di trasporto innovativi: l’esempio di Perugia

    Directory of Open Access Journals (Sweden)

    Leonardo Naldini

    2010-10-01

    Full Text Available La città di Perugia ha, fin dagli anni ’70, unito alla sua capacità di attrazione turistica, dovuta al patrimonio storico ambientale plurimillenario, una volontà di affrontare il tema della mobilità urbana in maniera profondamente innovativa ed ambientalmente sostenibile. Il concetto della creazione di parcheggi di attestazione, serviti da percorsi meccanizzati di risalita verso l’acropoli, è stato recentemente ampliato dalla creazione del Minimetro, mezzo di trasporto innovativo, dal ridottissimo impatto ambientale, che unisce in soli 12 minuti, con un servizio semicontinuo, l’area di valle di Pian di Massiano, dotata di un capace parcheggio da circa 2800 posti auto, al centro cittadino, servendo diversi quartieri urbani. Tale sistema di trasporto, corridoio forte del trasporto pubblico urbano, ha fornito lo spunto per attuare una nuova modalità di gestione dei flussi turistici, che individua nel Minimetro la modalità principale di accesso al centro storico sia per i gruppi a numero ridotto, sia per i gruppi organizzati in arrivo con i bus turistici. L’organizzazione della mobilità turistica che ne è derivata costituisce un ulteriore passo in avanti lungo quell’itinerario di gestione della città che cerca di coniugare l’attrattiva turistica, con le sue ricadute in termini di crescita economica, e la salvaguardia del patrimonio storico artistico e della qualità della vita dei cittadini. Gli scenari futuri vedono un’iniezione di tecnologia in questo contesto, con l’introduzione nella gestione dei flussi turistici dei concetti di accreditamento, dell’infomobilità come supporto alle politiche urbane, del controllo unito alla fornitura di servizi georeferenziati.

  9. Elimination of Cu (II) and Zn (II) ions in mono-element and the bi ...

    African Journals Online (AJOL)

    Elimination of Cu (II) and Zn (II) ions in mono-element and the bi-element aqueous solutions by adsorption on natural clay of Bikougou (Gabon) ... The modeling of the experimental results is better achieved by application of. Freundlich adsorption isotherm and Langmuir adsorption isotherm concerning the adsorption of Cu ...

  10. Bioconversion of Mono- and Sesquiterpenoids by Recombinant Human Cytochrome P450 Monooxygenases

    NARCIS (Netherlands)

    Julsing, Mattijs K.; Fichera, Mario A.; Malz, Frank; Ebbelaar, Monique; Bos, Rein; Woerdenbag, Herman J.; Quax, Wim J.; Kayser, Oliver

    2008-01-01

    Cytochrome P450 monooxygenases play an important role in the biosynthesis and metabolism of terpenoids. We explored the potential of recombinant human liver cytochrome P450 monooxygenases CYP1A2, CYP2C9, and CYP3A4, heterologously expressed in Escherichia coli, to convert mono- and sesquiterpenoids

  11. Emotions in freely varying and mono-pitched vowels, acoustic and EGG analyses.

    Science.gov (United States)

    Waaramaa, Teija; Palo, Pertti; Kankare, Elina

    2015-12-01

    Vocal emotions are expressed either by speech or singing. The difference is that in singing the pitch is predetermined while in speech it may vary freely. It was of interest to study whether there were voice quality differences between freely varying and mono-pitched vowels expressed by professional actors. Given their profession, actors have to be able to express emotions both by speech and singing. Electroglottogram and acoustic analyses of emotional utterances embedded in expressions of freely varying vowels [a:], [i:], [u:] (96 samples) and mono-pitched protracted vowels (96 samples) were studied. Contact quotient (CQEGG) was calculated using 35%, 55%, and 80% threshold levels. Three different threshold levels were used in order to evaluate their effects on emotions. Genders were studied separately. The results suggested significant gender differences for CQEGG 80% threshold level. SPL, CQEGG, and F4 were used to convey emotions, but to a lesser degree, when F0 was predetermined. Moreover, females showed fewer significant variations than males. Both genders used more hypofunctional phonation type in mono-pitched utterances than in the expressions with freely varying pitch. The present material warrants further study of the interplay between CQEGG threshold levels and formant frequencies, and listening tests to investigate the perceptual value of the mono-pitched vowels in the communication of emotions.

  12. Conformational studies on pertrimethylsilyl derivatives of some mono- and disaccharides by 220 MHz PMR spectroscopy

    NARCIS (Netherlands)

    Vliegenthart, J.F.G.; Streefkerk, D.G.; Bie, M.J.A. de

    1973-01-01

    The complete interpretation of 220 MHz PMR spectra and the accurate chemical shifts and coupling constants, obtained after computer simulation of the spectra, of a number of TMS-mono and -disaccharides are given. By means of an adapted Karplus equation the conformation of the derivatives has been

  13. Removal of copper (II), iron (III) and lead (II) ions from Mono ...

    African Journals Online (AJOL)

    EJIRO

    Removal of copper (II), iron (III) and lead (II) ions from. Mono-component Simulated Waste Effluent by. Adsorption on Coconut Husk. Oyedeji O. Abdulrasaq* and Osinfade G. Basiru. Department of Science Laboratory Technology, Federal Polytechnic, Ilaro, Ogun State, Nigeria. Accepted 28 April 2010. The use of coconut ...

  14. Production of pulse in mono-cropped rice system in the coastal region of Eastern India

    International Nuclear Information System (INIS)

    Khan, A.R.; Nanda, P.; Chandra, Dinesh; Ghorai, A.K.; Behera, M.S.

    2001-04-01

    This experiment was undertaken with an objective to increase the yield of black-gram leguminous pulse crop through optimal doses of phosphatic fertilizer with supplemental irrigation in mono-cropped rice-fallow regions of India. Irrigation and phosphorus fertilizer application were introduced for enhancing productivity of black-gram to provide better returns to available water resources

  15. Endotoxin testing of proteins for parenteral administration using the Mono Mac 6 assay

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    2000-01-01

    Pharmaceutical products containing proteins cause problems in testing for endotoxin and pyrogens. Many proteins interfere with the LAL test and the proteins are immunogenic in rabbits. The monocytic cell line Mono Mac 6 is an alternative assay for detection of endotoxin and other pyrogens....

  16. Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics

    Science.gov (United States)

    A series of mono- and multimeric polyamine-containing ferrocenyl complexes bearing a quinoline motif were prepared. The complexes were characterised by standard techniques. The molecular structure of the monomeric salicylaldimine derivative was elucidated using single crystal X-ray diffraction and w...

  17. Transient heating and evaporation of moving mono-component liquid fuel droplets

    DEFF Research Database (Denmark)

    Yin, Chungen

    2016-01-01

    This paper presents a complete description of a model for transient heating and evaporation of moving mono-component liquid fuel droplets. The model mainly consists of gas phase heat and mass transfer analysis, liquid phase analysis, and droplet dynamics analysis, which address the interaction be...

  18. Experimental damping assessment of a full scale offshore mono bucket foundation

    DEFF Research Database (Denmark)

    Gres, Szymon; Fejerskov, Morten; Ibsen, Lars Bo

    2016-01-01

    This paper quantifies the system damping of a offshore meteorological mast supported by a Mono Bucket foundation based on a long-term experimental campaign. The structure is located at Dogger Bank west, North Sea, and equipped with a measurement system monitoring acceleration, strain, inclination...

  19. Elevated levels of homocysteine increase IL-6 production in monocytic Mono Mac 6 cells

    NARCIS (Netherlands)

    van Aken, B. E.; Jansen, J.; van Deventer, S. J.; Reitsma, P. H.

    2000-01-01

    Hyperhomocysteinemia is a risk factor for atherosclerosis and thrombosis. The aim of this study was to analyze if exposure of monocytic cells to increased levels of homocysteine (HCY) induces the accumulation of inflammatory mediators. Interleukin (IL)-6 production by monocytic cell line Mono Mac 6

  20. Asynchronous replication, mono-allelic expression, and long range Cis-effects of ASAR6.

    Science.gov (United States)

    Donley, Nathan; Stoffregen, Eric P; Smith, Leslie; Montagna, Christina; Thayer, Mathew J

    2013-04-01

    Mammalian chromosomes initiate DNA replication at multiple sites along their length during each S phase following a temporal replication program. The majority of genes on homologous chromosomes replicate synchronously. However, mono-allelically expressed genes such as imprinted genes, allelically excluded genes, and genes on female X chromosomes replicate asynchronously. We have identified a cis-acting locus on human chromosome 6 that controls this replication-timing program. This locus encodes a large intergenic non-coding RNA gene named Asynchronous replication and Autosomal RNA on chromosome 6, or ASAR6. Disruption of ASAR6 results in delayed replication, delayed mitotic chromosome condensation, and activation of the previously silent alleles of mono-allelic genes on chromosome 6. The ASAR6 gene resides within an ∼1.2 megabase domain of asynchronously replicating DNA that is coordinated with other random asynchronously replicating loci along chromosome 6. In contrast to other nearby mono-allelic genes, ASAR6 RNA is expressed from the later-replicating allele. ASAR6 RNA is synthesized by RNA Polymerase II, is not polyadenlyated, is restricted to the nucleus, and is subject to random mono-allelic expression. Disruption of ASAR6 leads to the formation of bridged chromosomes, micronuclei, and structural instability of chromosome 6. Finally, ectopic integration of cloned genomic DNA containing ASAR6 causes delayed replication of entire mouse chromosomes.

  1. Asynchronous replication, mono-allelic expression, and long range Cis-effects of ASAR6.

    Directory of Open Access Journals (Sweden)

    Nathan Donley

    2013-04-01

    Full Text Available Mammalian chromosomes initiate DNA replication at multiple sites along their length during each S phase following a temporal replication program. The majority of genes on homologous chromosomes replicate synchronously. However, mono-allelically expressed genes such as imprinted genes, allelically excluded genes, and genes on female X chromosomes replicate asynchronously. We have identified a cis-acting locus on human chromosome 6 that controls this replication-timing program. This locus encodes a large intergenic non-coding RNA gene named Asynchronous replication and Autosomal RNA on chromosome 6, or ASAR6. Disruption of ASAR6 results in delayed replication, delayed mitotic chromosome condensation, and activation of the previously silent alleles of mono-allelic genes on chromosome 6. The ASAR6 gene resides within an ∼1.2 megabase domain of asynchronously replicating DNA that is coordinated with other random asynchronously replicating loci along chromosome 6. In contrast to other nearby mono-allelic genes, ASAR6 RNA is expressed from the later-replicating allele. ASAR6 RNA is synthesized by RNA Polymerase II, is not polyadenlyated, is restricted to the nucleus, and is subject to random mono-allelic expression. Disruption of ASAR6 leads to the formation of bridged chromosomes, micronuclei, and structural instability of chromosome 6. Finally, ectopic integration of cloned genomic DNA containing ASAR6 causes delayed replication of entire mouse chromosomes.

  2. 21 CFR 172.856 - Propylene glycol mono- and diesters of fats and fatty acids.

    Science.gov (United States)

    2010-04-01

    ... fatty acids. 172.856 Section 172.856 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... diesters of fats and fatty acids. Propylene glycol mono- and diesters of fats and fatty acids may be safely... and/or fatty acids in compliance with § 172.860 and/or oleic acid derived from tall oil fatty acids in...

  3. Síntesis de mono y diitaconatos de alquilo y arilo

    Directory of Open Access Journals (Sweden)

    Francisco J. Sánchez

    1997-01-01

    Full Text Available Se presenta una técnica para la síntesis en laboratorio de mono y diitaconatos y la separación de los mismos por extracción selectiva con solventes orgánicos. La pureza de los productos se determina por cromatografía en capa fina y por espectroscopia infrarroja.

  4. Stability of Axially Compressed Single-Cell Mono-Symmetric Thin ...

    African Journals Online (AJOL)

    Compared with conventional structural columns, the pronounced role of instabilities complicates the behaviour and design of thin-walled columns. This study investigated the stability of axially compressed single-cell thin-walled column with mono-symmetric non-deformable cross-sections. The work involved a theoretical ...

  5. Study of half-sandwich mono and dinuclear complexes of platinum ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 124; Issue 3. Study of half-sandwich mono and dinuclear complexes of platinum group metals containing pyrazolyl pyridine analogues: Synthesis and spectral characterization. Venkateswara Rao Anna Kota Thirumala Prasad Peng Wang Kollipara Mohan Rao.

  6. Crystalline mono- and multilayer self-assemblies of oligothiophenes at the air-water interface

    DEFF Research Database (Denmark)

    Isz, S.; Weissbuch, I.; Kjær, K.

    1997-01-01

    The formation of Langmuir monolayers at the air-water interface has long been believed to be limited to amphiphilic molecules containing a hydrophobic chain and a hydrophilic headgroup. Here we report the formation of crystalline mono- and multilayer self-assemblies of oligothiophenes, a class...

  7. Cyclin D activates the Rb tumor suppressor by mono-phosphorylation.

    Science.gov (United States)

    Narasimha, Anil M; Kaulich, Manuel; Shapiro, Gary S; Choi, Yoon J; Sicinski, Piotr; Dowdy, Steven F

    2014-06-04

    The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release E2F transcription factors. However, this model remains unproven biochemically and the biologically active form(s) of Rb remains unknown. In this study, we find that Rb is exclusively mono-phosphorylated in early G1 phase by cyclin D:Cdk4/6. Mono-phosphorylated Rb is composed of 14 independent isoforms that are all targeted by the E1a oncoprotein, but show preferential E2F binding patterns. At the late G1 Restriction Point, cyclin E:Cdk2 inactivates Rb by quantum hyper-phosphorylation. Cells undergoing a DNA damage response activate cyclin D:Cdk4/6 to generate mono-phosphorylated Rb that regulates global transcription, whereas cells undergoing differentiation utilize un-phosphorylated Rb. These observations fundamentally change our understanding of G1 cell cycle progression and show that mono-phosphorylated Rb, generated by cyclin D:Cdk4/6, is the only Rb isoform in early G1 phase.

  8. Synthesis of Mono-PEGylated Growth Hormone Releasing Peptide-2 and Investigation of its Biological Activity.

    Science.gov (United States)

    Hu, Xiaoyu; Xu, Beihua; Zhou, Ziniu

    2015-10-01

    The purpose of this study was to investigate an efficient synthetic route to the mono-PEGylated growth hormone releasing peptide-2 (GHRP-2) and its biological activity in vivo. The commercially available key PEGylating reagent, mPEG-NHS ester, was successfully utilized to the synthesis of mono-PEGylated GHRP-2, during which the PEGylation profiles of GHRP-2 were monitored by high-performance liquid chromatography (HPLC). The product was purified by cation exchange chromatography, and its biological activity was conducted in rats. The desired mono-PEGylated GHRP-2 as the major product was readily obtained in anhydrous aprotic solvent, such as dimethyl formamide (DMF) and dimethylsulfoxide (DMSO), when the molar ratio of mPEG-NHS ester to GHRP-2 was fixed to be 0.8:1. The products were characterized by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. The evaluation of the biological activity for the products showed that the mono-PEGylated GHRP-2 gave a more stable activity than GHRP-2, suggesting that PEGylation led to the increase in the half-life of GHRP-2 in plasma without greatly impairing the biological activity. PEGylation of the GHRP-2 is a good choice for the development of the GHRP-2 applications.

  9. The Simple Mono-Canal Algorithm for the Temperature Estimating of ...

    African Journals Online (AJOL)

    The knowledge of the surface temperature is strongly required in several applications, for instance in agrometeorology, climatology and environmental studies. In this study we have developed an algorithm mono-canal to estimate land surface temperature (Ts) in spectral band as the infrared channel (IR) of METEOSAT-7.

  10. Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity.

    Science.gov (United States)

    Tremblay, Cédric S; Huang, Feng Fei; Lévesque, Georges; Carreau, Madeleine

    2018-02-20

    The Hairy Enhancer of Split 1 (HES1) is a transcriptional repressor that regulates cellular proliferation and differentiation during development. We previously found an interaction between HES1 and Fanconi anemia (FA) proteins. FA is a hematological and developmental disorder caused by mutations in more than 20 different genes. Eight FA gene products form a nuclear core complex containing E3 ligase activity required for mono-ubiquitination of FANCD2 and FANCI, both of which are FA proteins. Given that HES1 interacts with members of the FA core complex, the aim of this study was to determine whether HES1 is mono-ubiquitinated via the FA core complex. We show that HES1 is mono-ubiquitinated on a highly-conserved lysine residue that is located within a FA-like recognition motif. HES1 modification is dependent on a functional FA complex. Absence of HES1 mono-ubiquitination affects transcriptional repression of its own promoter. This study uncovers a novel post-translational modification of HES1 that regulates its transcriptional activity and suggests that ubiquitination of HES1 occurs in a FA core complex-dependent manner.

  11. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA released the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from ot...

  12. The nest predator assemblage for songbirds in Mono Lake basin riparian habitats

    Science.gov (United States)

    Quresh S. Latif; Sacha K. Heath; Grant Ballard

    2012-01-01

    Because nest predation strongly limits avian fitness, ornithologists identify nest predators to inform ecological research and conservation. During 2002–2008, we used both video-monitoring of natural nests and direct observations of predation to identify nest predators of open-cup nesting riparian songbirds along tributaries of Mono Lake, California. Video cameras at...

  13. Co-metabolic degradation of mono-fluorophenols by the ectomycorrhizal fungi Pisolithus tinctorius.

    Science.gov (United States)

    Franco, Albina R; Ferreira, António C; Castro, Paula M L

    2014-09-01

    The release of fluorinated organic compounds from fire retardants or agrochemical products may have a significant negative effect on soil ecosystems. In this study, the ability of Pisolithus tinctorius to tolerate and degrade mono-fluorophenols (FP) was assessed. In vitro studies showed fungal growth in the presence of 0.45mM of 2-FP and 3-FP, but not in the presence of 4-FP. P. tinctorius was able to degrade up to 79% and 92% of 1mM 2-FP and 3-FP, respectively, in glucose supplemented liquid medium, suggesting that 2- and 3-FP degradation occurred in co-metabolism with glucose consumption. 3-Fluorocatechol (FC) and 4-FC were identified as metabolic intermediates using HPLC and LC-MS. Liberation of fluoride was not detected suggesting that a fluorinated dead-end product was formed. In extracts of cells collected at the end of cultures supplemented with the mono-FPs, a metabolic intermediate compatible with a mass corresponding to a fluoromuconate compound, according to LC-MS data, was recovered. The results further suggest that ectomycorrhizal fungi may be able to degrade mono-FP in pure culture while using glucose as a carbon source, through a similar pathway as that found in bacteria. To our knowledge, this is the first time that degradation of mono-FPs by an ectomycorrhizal fungus is reported. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Health Disparities and Relational Well-Being between Multi- and Mono-Ethnic Asian Americans

    Science.gov (United States)

    Zhang, Wei

    2013-01-01

    Focusing on Hawaii, a state with 21.3% of the population being multi-racial according to the 2010 U.S. Census, this study aims to examine the existence and nature of health disparities between mono- and multi-ethnic Asian Americans and the importance of Relational Well-Being in affecting the health of Asian Americans. A series of ordinary least…

  15. Chemostat modeling of Escherichia coli persistence in conventionalized mono-associated and streptomycin-treated mice

    DEFF Research Database (Denmark)

    Rang, C.; Midtvedt, T.; Molin, Søren

    2001-01-01

    We have previously shown that Escherichia coli BJ4 has similar doubling time in mice that are mono-associated (having only the inoculated E. coli BJ4) or streptomycin-treated (having mainly gram-positive bacteria plus the inoculated E. coli BJ4). We also showed that when the mice were conventiona......We have previously shown that Escherichia coli BJ4 has similar doubling time in mice that are mono-associated (having only the inoculated E. coli BJ4) or streptomycin-treated (having mainly gram-positive bacteria plus the inoculated E. coli BJ4). We also showed that when the mice were...... the decrease in colony counts, we analyzed our previous results by a chemostat model. The analysis shows that the increasing doubling time alone is sufficient to explain the decrease in colony counts in mono- associated mice, but not in the streptomycin-treated mice. The observed decreasing rate in colony...... counts in streptomycin- treated mice is slower than predicted. Furthermore, whereas the model predicted a decrease to extinction in both mice, the E. coli persist at a frequency 10-80 times higher in streptomycin- treated mice than in mono-associated mice. Thus, while a chemostat model is able to explain...

  16. Retrograde axoplasmic flow of serotonin in central mono-aminergic neurons

    International Nuclear Information System (INIS)

    Leger, Lucienne; Pujol, J.-F.; Bobillier, Pierre; Jouvet, Michel

    1977-01-01

    Following an injection of 3 H-5 HT in the neostriatum of the Rat, the tracer is transported by axoplasmic retrograde flow to the cell groups containing mono-aminergic neurons which are known or thought to have afferences to this structure: substantia nigra, dopaminergic group A8 and n. raphe dorsalis [fr

  17. Maillard reaction products of rice protein hydrolysates with mono-, oligo- and polysaccharides

    Science.gov (United States)

    Rice protein, a byproduct of rice syrup production, is abundant but, its lack of functionality prevents its wide use as a food ingredient. Maillard reaction products of (MRPs) hydrolysates from the limited hydrolysis of rice protein (LHRP) and various mono-, oligo- and polysaccharides were evaluat...

  18. La logistica nei processi di trasformazione dell’area orientale di Napoli

    Directory of Open Access Journals (Sweden)

    Adriana Galderisi

    2010-07-01

    Full Text Available Stoccaggio e trasporto merci hanno assunto, già da alcuni anni, un ruolo rilevante nell’area orientale di Napoli, con impatti significativi sulla qualità urbana ed ambientale dell’area. In quest’area, anche grazie alla sua vicinanza ai principali nodi della mobilità (porto, aeroporto, stazione ferroviaria e alla significativa presenza di aree produttive dismesse o in dismissione, trovano oggi spazio numerose attività di stoccaggio e spedizione merci, in molti casi localizzate all’interno di ex aree industriali, in assenza di una reale ottica “sistemica”. Pertanto, a partire da una breve disamina dell’evoluzione dell’area orientale e di quanto previsto dagli strumenti urbanistici vigenti per la sua trasformazione, il contributo focalizza l’attenzione sul ruolo attuale dslle attività di stoccaggio e trasporto merci nell’area. Quindi, sulla base di alcune recenti esperienze di italiane e in riferimento ad ipotesi già avanzate per l’organizzazione di una piattaforma logistica nell’area orientale di Napoli -quale strumento per ottimizzare le necessità di stoccaggio e trasporto merci riducendone le esternalità negative- valuta la compatibilità di tali scelte con le prospettive di evoluzione/trasformazione dell’area e il potenziale ruolo che l’area potrebbe svolgere in una prospettiva di ri-organizzazione del trasporto merci in ambito urbano.

  19. EGNOS: è ora di usarlo

    Directory of Open Access Journals (Sweden)

    Fabrizio Bernardini

    2006-04-01

    anche dell’applicazione descritta nella rubrica Reports di questo stesso numero, vogliamo evidenziare alcuni aspetti del sistema che non ci sembra ancora ben apprezzato a livello utente e due prospettive note come SISNET ed ESA ALIVE.

  20. Il contributo di una Unitá Operativa Complessa: di Infettivologia Pediatrica durante l'epidemia di morbillo in Campania.

    Directory of Open Access Journals (Sweden)

    G. De Lorenzo

    2003-05-01

    Full Text Available

    Il morbillo è un importante problema di Sanità Pubblica che comporta un elevato rischio di complicanze con conseguenti eccessi di ospedalizzazione, mortalità e costi elevati.

    Obiettivi: Valutare incidenza, decorso clinico, complicanze e scelte terapeutiche in bambini ospedalizzati per morbillo, nonché l’impatto dell’epidemia su strutture ed operatori di una U.O.C. di Infettivologia Pediatrica con 16 p.l.

    Metodologia: dalle cartelle cliniche dei bambini ricoverati per morbillo presso l’U.O.C. di Pediatria Infettivologica dell’Ospedale Pausillipon di Napoli, nel corso dell’epidemia verificatasi in Campania tra gennaio e maggio 2002, sono stati raccolti, mediante una apposita griglia di rilevazione, i dati socio anagrafici, quelli relativi a decorso della malattia, eventuali complicanze, scelte terapeutiche adottate, stato immunitario del bambino e della madre, possibile fonte di contagio, motivazione al ricovero. Su 78 bambini ricoverati (38F e 40M, età media di 4,2 anni (range 0,1 14 anni, di cui 20 con età inferiore a 15 mesi, 42 hanno presentato complicanze: 27 broncopolmoniti, di cui 4 di presumibile origine virale e 23 da presumibile sovrainfezione batterica, 7 laringotracheobronchiti (croup, 4 diarrea con disidratazione, 1 otite media, 4 piastrinopenia transitoria, 2 stomatiti, 1 cistite emorragica, 1 meningoencefalite. Oltre alla terapia antibiotica e cortisonica (quando indicate, 27 bambini hanno ricevuto una singola somministrazione di Vitamina A, con decorso favorevole della malattia e nessun effetto collaterale. In soli due bambini era stata praticata la vaccinazione antimorbillo.

    Conclusioni: i dati confermano l’importanza della vaccinazione antimorbillo e l’opportunità di anticiparla a 6 mesi in corso di epidemia (nella quasi totalità dei casi di età ‹15 mesi la fonte di contagio è stata la malattia in

  1. La differenziazione nei servizi di trasporti intermodali

    OpenAIRE

    Midoro, Renato

    2000-01-01

    La prestazione del servizio via mare “pier to pier”, sia il servizio “door to door”, attraverso il coordinamento e il controllo di tutti i gangli marittimi, portuali, terrestri e ferroviari, presentano caratteri di omogeneità e il fatto di offrirli rappresenta il requisito base, un “essential” richiesto dai clienti globali. Assicurare la qualità nel trasporto via mare e multimodale dei carichi rappresenta la condizione di base per poter competere. Il rapporto tra l’impresa di trasporto interm...

  2. A role of intracellular mono-ADP-ribosylation in cancer biology.

    Science.gov (United States)

    Scarpa, Emanuele S; Fabrizio, Gaia; Di Girolamo, Maria

    2013-08-01

    During the development, progression and dissemination of neoplastic lesions, cancer cells can hijack normal pathways and mechanisms. This includes the control of the function of cellular proteins through reversible post-translational modifications, such as ADP-ribosylation, phosphorylation, and acetylation. In the case of mono-ADP-ribosylation and poly-ADP-ribosylation, the addition of one or several units of ADP-ribose to target proteins occurs via two families of enzymes that can generate ADP-ribosylated proteins: the diphtheria toxin-like ADP-ribosyltransferase (ARTD) family, comprising 17 different proteins that are either poly-ADP-ribosyltransferases or mono-ADP-ribosyltransferases or inactive enzymes; and the clostridial toxin-like ADP-ribosyltransferase family, with four human members, two of which are active mono-ADP-ribosyltransferases, and two of which are enzymatically inactive. In line with a central role for poly-ADP-ribose polymerase 1 in response to DNA damage, specific inhibitors of this enzyme have been developed as anticancer therapeutics and evaluated in several clinical trials. Recently, in combination with the discovery of a large number of enzymes that can catalyse mono-ADP-ribosylation, the role of this modification has been linked to human diseases, such as inflammation, diabetes, neurodegeneration, and cancer, thus revealing the need for the development of specific ARTD inhibitors. This will provide a better understanding of the roles of these enzymes in human physiology and pathology, so that they can be targeted in the future to generate new and efficacious drugs. This review summarizes our present knowledge of the ARTD enzymes that are involved in mono-ADP-ribosylation reactions and that have roles in cancer biology. In particular, the well-documented role of macro-containing ARTD8 in lymphoma and the putative role of ARTD15 in cancer are discussed. © 2013 The Authors Journal compilation © 2013 FEBS.

  3. Surfactant-assisted synthesis of mono-dispersed cubic BaTiO{sub 3} nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Hai, Chunxi [National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560 (Japan); Inukai, Koji; Takahashi, Yosuke [Noritake Co., Limited, RD Center, Miyoshi 470-0293 (Japan); Izu, Noriya; Akamatsu, Takafumi; Itoh, Toshio [National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560 (Japan); Shin, Woosuck, E-mail: w.shin@aist.go.jp [National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560 (Japan)

    2014-09-15

    Mono-dispersed BaTiO{sub 3} nanoparticles have been prepared via the assistance of capping agent poly(vinylpyrrolidone) (PVP). - Highlights: • BaTiO{sub 3} nanoparticles with single cubic crystal structure. • Poor dispersibility of nanoparticles has been overcome by in situ modification way. • Growth competition between BaTiO3 core and polymer shell. - Abstract: In this study, poly(vinylpyrrolidone)-assisted synthesis of mono-dispersed BaTiO{sub 3} nanoparticles have been reported. The various processing parameters, namely, refluxing temperature, KOH concentration, and poly(vinylpyrrolidone) concentration, have been varied, and the effects on the growth of BaTiO{sub 3} particles have been analyzed systematically. X-ray diffraction studies indicated that poly(vinylpyrrolidone) did not affect the crystal structure, but rather influenced the crystal lattice structure. In addition, the use of surfactant poly(vinylpyrrolidone) hindered the agglomeration of the nanoparticles, and facilitated the formation of mono-dispersed core–shell organic/inorganic hybrid nanocomposite. Furthermore, the mineralizer KOH promoted the dissolution of reactants and promoted the crystallization of BaTiO{sub 3} particles. Accordingly, the dissolution-precipitation scheme was believed to be the mechanism underlying the formation of BaTiO{sub 3} particles. This was further substantiated by the experimental observations, which indicated that the nucleation and crystallization of the particles was affected by the KOH concentration in the reaction system. Finally, the formation of mono-dispersed core–shell nanocomposites proceeded via reaction limited cluster aggregation. We believe that the method proposed in this study could be extended for the synthesis of mono-dispersed nanoparticles for industrial applications.

  4. L’identificazione di virus citopatogeni isolati dall’ambiente:ricerca ed applicazione di protocolli analitici

    Directory of Open Access Journals (Sweden)

    A. Carducci

    2003-05-01

    Full Text Available

    Obiettivi: la ricerca dei virus enterici in matrici ambientali, soprattutto nei reflui urbani, risulta di grande interesse sia per la valutazione del rischio di natura virale sia per compiere studi epidemiologici.

    Lo scopo di questo lavoro è stato l’applicazione parallela di diverse tecniche attualmente in uso in virologia clinica a isolati citopatogeni ambientali al fine di ottenere una precisa identificazione degli agenti rilevati.

    Metodi: sono stati analizzati 21 campioni di aerosol, provenienti da impianti di depurazione di reflui civili a fanghi attivi, e risultati citopatogeni in colture di cellule BGM.

    Dopo una nuova semina in “shell vials”, su tre linee cellulari continue per mettere in evidenza eventuali differenze nello spettro di citopatogenicità. Per l’identificazione degli isolati virali, sono state adottate in parallelo: microscopia elettronica, tecniche biomolecolari di amplificazione genica, elettroforesi su gel di poliacrilamide (PAGE, test immunoenzimatici, sieroneutralizzazione.

    Risultati: la semina in “shell vials” ha confermato la
    presenza di particelle virali infettive in tutti i campioni
    tranne uno; inoltre ha permesso di ridurre il
    tempo di comparsa dell’effetto citopatico a 3-4 giorni
    contro i 6-8 giorni necessari seminando in fiasche.
    La microscopia elettronica ha individuato la presenza
    di particelle enterovirus-simili in 18 dei 21
    campioni e di virioni della famiglia Reoviridae in 8.
    La positività dei campioni è stata ottenuta, inoltre,
    con la RT-PCR, per 2 campioni di enterovirus e 2 di
    reovirus e con la PAGE in 6 campioni. Il presente
    studio ha portato ad un’identificazione sufficientemente
    certa di reovirus in 2 campioni e di enterovirus
    in 1 campione.

    Conclusioni: l’identificazione di isolati ambientali si

  5. Teoria dell'elettromagnetismo fenomeni e leggi fondamentali : energia dei campi e delle distribuzioni di carica, applicazioni di meccanica analitica e statistica, teoria della relatività, emissione e propagazione di onde elettromagnetiche

    CERN Document Server

    Tenaglia, Livio

    1956-01-01

    Leggi fondamentali dell'elettromagnetismo ; le equazioni di Lagrange, di Hamilton e di Jacobi, il principio di Fermat ; applicazioni di meccanica analitica all'elettromagnetismo ; teoria statica dell'irraggiamento ; fondamenti di teoria della relatività ; propagazione delle onde elettromagnetiche proprietà elementari dei conduttori ; emissione di onde elettromagnetiche ; richiami analitici ; unità di misura per le grandezze del campo elettromagnetico.

  6. Metal ion recognition via 'selective detuning'. The interaction of selected transition and post-transition metal ions with a mono-N-benzylated O2N3-donor macrocycle and its xylyl-bridged ring analogue.

    Science.gov (United States)

    Fainerman-Melnikova, Marina; Nezhadali, Azizollah; Rounaghi, Gholamhossin; McMurtrie, John C; Kim, Jeong; Gloe, Karsten; Langer, Matthias; Lee, Shim Sung; Lindoy, Leonard F; Nishimura, Tomoko; Park, Ki-Min; Seo, Joobeom

    2004-01-07

    The interaction of cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II), silver(I) and lead(II) with symmetrical mono-N-benzylated and xylyl-linked macrocyclic ligands derived from the O2N3-macrocycle, 1,12,15-triaza-3,4:9,10-dibenzo-5,8-dioxacycloheptadecane, has been investigated. The log K values for the respective 1 : 1 complexes in 95% methanol (I= 0.1; Et4NClO4, 25 degrees C) of the mono-benzylated derivative have been determined potentiometrically and the results compared with the values obtained previously for the parent (non-benzylated) ring system as well as for related di- and tri-benzylated macrocyclic species. Mono-benzylation results in slightly enhanced stability for the 1 : 1 silver(I) complex while the values for the corresponding complexes of the other six ions are in each case decreased even though the highest stability is still maintained for the 1 : 1 copper(II) complex. The log K results are in accord with a previous proposal that N-benzylation of amine-containing macrocyclic rings of the present type will normally have only a minor (positive or negative) influence on the affinity towards silver(I) while the corresponding binding strengths towards the remaining six metal ions are significantly reduced-behaviour we term 'selective detuning'. Competitive seven-metal transport experiments across a bulk chloroform membrane have been performed using both ligand systems as ionophores. In parallel to the log K results, transport selectivity for copper(II) was exhibited by both systems, with similar transport efficiencies being evident when compared on a 'per macrocyclic cavity' basis.

  7. idea di poetere e miti di rinascita nell'opera di sibilla aleramo

    African Journals Online (AJOL)

    User

    rispondente ai dettami più autentici della sua arte, e sullo stretto legame che correla tale concetto ai vari miti di rinascita che compaiono nella sua opera più matura. La riflessione della Aleramo sul potere, inteso nel senso specificato sopra, si articola fondamentalmente su due piani che, pur essendo distinti, sono tuttavia ...

  8. Analisa Kepuasan Konsumen Di Restaurant “X” Di Surabaya

    OpenAIRE

    Wibowo, Handoko Surya; Tunggal, Gabriel Jeffri Wea; Jokom, Regina

    2015-01-01

    Penelitian ini ditunjukan untuk menganalisa tingkat kesenjangan antara harapan dari konsumen terhadap Kenyataan yang diterima oleh konsumen dan mengukur tingkat kepuasan konsumen di Restoran “X” dengan menggunakan atribut DINESERV. Penelitian ini menggunakan Importance Performance Analysis(IPA). Hasil dari penelitian ini adalah kesenjangan antara harapan dan Kenyataan yang diukur menggunakan atribut DINESERV adalah Kenyataan yang diterima oleh konsumen sangat tidak sesuai dengan harapan konsu...

  9. Il Maestro della Commenda di Meldola e la magione ospitaliera di San Giovanni Battista

    Directory of Open Access Journals (Sweden)

    Paolo Cova

    2012-02-01

    Full Text Available L’intervento propone, attraverso l’indagine di alcuni dipinti di area forlivese, una prima ricostruzione della personalità di un interessante interprete locale del XV secolo, provvisoriamente denominato Maestro della Commenda di Meldola. Lo studio, parte integrante della mia tesi di dottorato, prende le mosse dall’analisi dell’affresco dell’Oratorio di San Giovanni Battista a Meldola, per poi allargarsi ad altre emergenze del territorio circostante, fino ai lacerti pittorici emersi nella chiesa della Santissima Trinità di Forlì. Nella prima parte dell’articolo viene ricostruita la storia dell’Oratorio di San Giovanni Battista presso Villa Fronticelli a Meldola: già magione templare di Santa Maria Biacque, nel 1312, in seguito al processo ai templari, passò alle dipendenze della precettoria dei cavalieri gerosolimitani di San Giovanni di Palareto. La realizzazione dell’affresco deve essere probabilmente inserita all’interno dei lavori di ristrutturazione intrapresi dai giovanniti dopo la metà del XV secolo. Nella seconda parte dell’articolo invece si procede alle indagini tecniche e stilistiche relative alla pittura murale che rappresenta la Madonna col Bambino e San Giovanni Battista. L’affresco mutilo è opera di un interessante maestro che agisce nella sfera del tardogotico locale, mostrando però tenui accenti rinascimentali caratteristici alla pittura forlivese tra sesto e settimo decennio del Quattrocento. Muovendo dalle ricerche di Anna Tambini e Giordani Viroli, attraverso l’analisi di diverse testimonianze del territorio, viene così proposta la ricostruzione di un corpus pittorico caratterizzato da stringenti affinità stilistiche, che, confermando l’appartenenza del suo anonimo pittore ad un milieu stilistico caro ad altri interpreti forlivesi del periodo, come il Maestro di Castrocaro o il Maestro di San Pier Damiani, aiuta ulteriormente a chiarire il panorama artistico romagnolo all’avvento della

  10. Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300.

    Science.gov (United States)

    Ling, Feng; Tang, Yi; Li, Ming; Li, Qing-Shu; Li, Xian; Yang, Lian; Zhao, Wei; Jin, Cong-Cong; Zeng, Zhen; Liu, Chang; Wu, Cheng-Fang; Chen, Wen-Wen; Lin, Xiao; Wang, Ya-Lan; Threadgill, Michael D

    2017-09-22

    Relatively little attention has been paid to ADP-ribosylated modifications of histones, especially to mono-ADP-ribosylation. As an increasing number of mono-ADP-ribosyltransferases have been identified in recent studies, the functions of mono-ADP-ribosylated proteins have aroused research interest. In particular, histones are substrates of some mono-ADP-ribosyltransferases and mono-ADP-ribosylated histone have been detected in physiological or pathological processes. In this research, arginine-117 (Arg-117; R-117) of hsitone3(H3) is identified as the a site of mono-ADP-ribosylation in colon carcinoma(the first such site to be identified); this posttranslational modification may promote the proliferation of colon carcinoma cells in vitro and in vivo . Using a point-mutant lentivirus transfection and using an activator of P300 allowed us to observe the mono-ADP-ribosylation at H3R117 and enhancement of the activity of P300 to up-regulate the level of acetylated β-catenin, which could increase the expression of c-myc and cyclin D1.

  11. Obbligo di sicurezza del prestatore di lavoro ed effettività della tutela antinfortunistica

    OpenAIRE

    Alessia Gabriele

    2012-01-01

    Il saggio affronta il tema della sicurezza e della salute dei lavoratori quale diritto fondamentale. Dopo l'analisi del panoram­a normativo internazionale e comunitario, l'A. si sofferma sulla posi­zione di garanzia assegnata al prestatore di lavoro subordinato nell'ordinamento interno, con particolare attenzione ai diritti di for­mazione e di informazione intimamente connessi al correlati­vo obbli­go di sicurezza del prestatore di lavoro. Le conclusioni cui giunge una parte della giurisprude...

  12. Ricerche sugli enterobatteri nelle feci di Chirotteri

    Directory of Open Access Journals (Sweden)

    Dino Scaravelli

    2003-10-01

    Full Text Available Dal 2002, grazie al protocollo stipulato tra il gruppo di studio chirotteri del Museo di Onferno e l?Istituto Zooprofilattico Sperimentale della Lombardia e dell?Emilia, sezione di Forlì, si è iniziato un progetto di studio sulla enteroflora di varie specie di Chirotteri. I campioni fecali o più raramente da carcassa, sono stati procssati mediante sistemi standardizzati e tipizzati mediante Enterotubes, creando anche una collezione di riferimento. Le ricerche ad oggi hanno interessato campioni provenienti da diverse regioni e da un certo pool di specie: Myotis daubentonii, M. blythii, M. myotis, Miniopterus schreibersii, Nyctalus noctula, Pipistrellus kuhlii, Rhinolophus ferrumequinum, R. hipposideros. Non sono stati mai identificati vettori di zoonosi o altri batteri che siano di alcun interesse per la salute umana, mentre si descrivono qui alcune specie nuove per la fauna italiana in relazione ai Chirotteri quali Providencia alcalifaciens in N.noctula, Serratia marcescens in M. schreibersii e Klebsiella oezaenale in R. hipposideros. Il lavoro invita inoltre ad una maggiore collaborazione e a stringere accordi per ampliare la possibile raccolta dei campioni.

  13. The "Bestie di Satana" murders.

    Science.gov (United States)

    Birkhoff, Jutta; Candelli, Chiara; Zeroli, Stefania; La Tegola, Donatella; Carabellese, Felice

    2013-11-01

    In recent years, satanic groups have been responsible for various types and degrees of crimes. We report the case of a number of murders committed in Italy by a group of young people calling themselves the "Bestie di Satana". Forensic psychiatric assessment of the members of a satanic sect charged with the crime revealed that all the young people had a fragile, immature personality, a very low level of education and were socially disadvantaged. The trial of the members of the "Bestie di Satana" sect was concluded with the verdict of deliberate murder, and all the members were given long jail sentences. This report should lead us to explore social and cultural responses to juvenile satanism, statistically shown to be a relatively rare phenomenon but with a high criminal potential. © 2013 American Academy of Forensic Sciences.

  14. Una nuova rubrica di Archeomatica

    Directory of Open Access Journals (Sweden)

    Renzo Carlucci

    2005-02-01

    Full Text Available La parte umanistica della nostra rivista è in espansione e da questo numero si parte con un'altra avventura che si accoda a quella già avviata l'anno scorso con Arte e Scienza. Archeologia, Informatica e Geomatica s'incontreranno su uno spazio loro dedicato, la rubrica di Archeomatica. Essa prende il via con un articolo sul Sistema Informativo Geografico della Valle del Colosseo, le cui varie cartografie, da quelle storiche fino alle più recenti, i disegni e i rilievi di scavo s'integrano in modelli numerici CAD, tridimensionali, riuniti da un'unica relazione spaziale che li colloca e li indicizza mettendoli a disposizione dell'utente.

  15. 1. Mono([8]annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    International Nuclear Information System (INIS)

    Boussie, T.R.

    1991-10-01

    A reproducible, high-yield synthesis of mono([8]annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono([8]annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported

  16. 1. Mono([8]annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    Energy Technology Data Exchange (ETDEWEB)

    Boussie, Thomas Richard [Univ. of California, Berkeley, CA (United States)

    1991-10-01

    A reproducible, high-yield synthesis of mono([8]annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono([8]annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

  17. 1. Mono((8)annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

    Energy Technology Data Exchange (ETDEWEB)

    Boussie, T.R.

    1991-10-01

    A reproducible, high-yield synthesis of mono((8)annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono((8)annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

  18. Metodologie di rilievo tra ricerca e innovazione tecnologica per un caso di archeologia medievale: Torre Melissa in provincia di Crotone

    Directory of Open Access Journals (Sweden)

    Francesca Fatta

    2017-12-01

    Full Text Available   Il complesso di Torre Melissa è uno dei manufatti storici di pregio che si affacciano sulle coste calabresi del mare Jonio. Una torre-castello d’epoca aragonese sottoposta ad un restauro conservativo agli inizi degli anni duemila. In quella occasione, la torre fu rilevata con procedure manuali e l’ausilio di una stazione totale. Nel 2014 si è proceduto con un rilievo eseguito con strumenti digitali d’alta definizione (laser scanner, fotografia digitale e telecamera applicata a drone. La comparazione tra i due rilievi, effettuati con metodologie differenti, mostrano delle disuguaglianze semantiche evidenti che mettono in risalto i progressi delle odierne strumentazioni per la definizione di modelli 3D d’altissima precisione, fondamentali per le pratiche di tutela e valorizzazione di un patrimonio architettonico complesso e stratificato

  19. METAMORFOSIS PESANTREN DI ERA GLOBALISASI

    Directory of Open Access Journals (Sweden)

    Muhammad Jamaluddin

    2012-07-01

    Full Text Available Abstrak: Tulisan ini mendeskripsikan perkembangan peran dan fungsi pesantren sejak awal "kelahirannya" yang terjadi pada kehidupan masyarakat tradisional sampai pada perubahan model pesantren yang menyesuaikan dengan kemajuan teknologi informasi. Model pendidikan pesantren menjamur jauh sebelum lembaga pendidikan formal didirikan di Indonesia, sehingga kontribusinya sangat besar dalam pembangunan bangsa ini. Mempertahankan eksistensinya di tengah tren perkembangan masyarakat modern tentunya tidak mudah. Karena pesantren, di satu sisi, merupakan lembaga penguatan keagamaan dan moral, tetapi di sisi lain ia harus mampu beradaptasi dan bermetamorfosis sesuai dengan perkembangan masyarakat modern. Tantangan besar dalam masyarakat modern adalah dekadensi moral dan agama, lambatnya laju perkembangan ekonomi masyarakat, dan tingginya angka konsumerisme masyarakat. Berdasarkan tantangan ini, pesantren dapat melakukan revitalisasi peran dan fungsinya sebagai lembaga pendidikan dan pusat pemberdayaan masyarakat.     Abstract: This paper describes the development of the role and function of pesantren starting from the beginning of "its birth"  in traditional society to model of pesantren the advancement of information technology. Pesantren has flourished long before the formal educational institutions established in Indonesia. Thus, it has great contribution to the development of this nation. Maintaining its existency  in the middle of the development trend of modern society is certainly not easy for pesantren. In one side, it is an institution for strengthening of religious and moral issues but on the other hand it must be able to adapt and metamorphose in accordance with the development of modern society. The major challenges in modern society is the moral and religious decadence, the slow pace of economic development, and the high rate of consumerism. For these challenges, pesantren can revitalize its role and function as educational institutions

  20. Sviluppo di un sistema gis e webgis a supporto delle attività di bonifica del sito d'interesse nazionale di Biancavilla

    OpenAIRE

    Famoso, Daniele Antonino

    2015-01-01

    In seguito al rilevamento di un cluster di casi di mesotelioma nella città siciliana di Biancavilla, che si trova alle pendici del vulcano Etna, sono stati effettuati studi epidemiologici ad hoc e monitoraggi ambientali per evidenziare il ruolo e l eziologia di una fibra asbestiforme presente in una cava di pietra. Una dettagliata analisi chimica di anfiboli contenuti in questo materiale ha permesso la scoperta e l'individuazione di una nuova fibra: la fluoroedenite (NaCa2Mg5 (Si7Al) O22F2...

  1. La ricostruzione grafica del pavimento musivo di una villa romana

    Directory of Open Access Journals (Sweden)

    Caterina Gattuso

    2015-01-01

    Full Text Available Nel processo di analisi conoscitiva finalizzato alla conservazione e/o al restauro di un manufatto storico, la documentazione grafica offre un contributo importante ai fini della redazione del quadro anamnesico. Essa costituisce uno strumento conoscitivo che, nel rappresentare e registrare lo stato di conservazione nonché gli eventuali interventi di restauro cui il bene è stato sottoposto, permette di completare e di integrare le informazioni già ottenute mediante il dossier fotografico. In questo contesto si vuole dimostrare l’importanza del disegno informatico, da intendere come strumento utile per l’elaborazione di un corretto piano diagnostico, illustrando la ricostruzione grafica di una complessa pavimentazione musiva che decora un particolare ambiente di una villa di epoca romana posta sulle rive del lago d’Esaro nel comune di Roggiano Gravina (CS, ottenuta attraverso l’uso di un particolare software di design grafico e disegno vettoriale.

  2. Inquadramento generale di CASBEE (Comprehensive Assessment System for Building Environmental Efficiency, un sistema giapponese di classificazione e di certificazione

    Directory of Open Access Journals (Sweden)

    Raymond J. Cole

    2014-06-01

    Full Text Available Una premessa soggiacente alle valutazioni e certificazioni offerte dai principali sistemi di valutazione della performance ambientale degli immobili consiste nel fatto che, ove il mercato disponga di migliori prassi e informazioni, un client group con potere decisionale può e deve garantire la propria leadership ai fini di una responsabilità ambientale, affinché altri seguano il suo esempio per rimanere competitivi. La determinazione del coefficiente ambientale ha fornito ai proprietari degli immobili uno strumento credibile e obiettivo per comunicare ai potenziali inquilini le qualità ambientali dell’immobile che sarebbero interessati a prendere in affitto, iniziando così a rivedere le loro aspettative soffermandosi maggiormente su obiettivi più complessi in termini di rendimento, oltre che sui vantaggi derivanti dall’applicazione di una prassi tipica. Da più di vent’anni, la determinazione del coefficiente ambientale è confluita in un’area di studio e ricerca più che legittima. Gli strumenti di valutazione utilizzati a livello mondiale rientrano di norma in due categorie generiche: 1 quelli sviluppati dall’organizzazione di un Paese che, oltre ad amministrarlo e a garantirne l’efficienza, fornisce un opportuno supporto educativo e un’infrastruttura operativa. Tutti i principali sistemi riconosciuti – BREEAM, LEED, CASBEE, Green Star in Australia, ecc. – rientrano in questa categoria; 2 quelli sviluppati dagli studiosi per finalità di ricerca o nell’auspicio che diventino un sistema di certificazione, anche se a tutt’oggi non sono stati adottati in modo massiccio nei loro rispettivi Paesi.

  3. Effect of fuel composition on poly aromatic hydrocarbons in particulate matter from DI diesel engine; Particulate chu no PAH ni oyobosu nenryo sosei no eikyo

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, S.; Tatani, T.; Yoshida, H.; Takizawa, H.; Miyoshi, K.; Ikebe, H. [COSMO Research Institute, Tokyo (Japan)

    1997-10-01

    The effect of fuel composition on poly aromatic hydrocarbons (PAH) in particulate matter from DI diesel engine was investigated by using deeply desulfurized fuel and model fuel which properties are not interrelated. It was found that the deeply desulfurized fuel have effect on reducing PAH emissions. Furthermore, it was suggested that poly aromatics in the fuel affect PAH emissions and the influence of tri-aromatics in the fuel was promoted by the coexistence of mono-aromatics or naphthene. PAH formation scheme from each fuel component was proposed by chemical thermodynamic data. 4 refs., 8 figs., 3 tabs.

  4. Photochemical properties of mono-, tri-, and penta-cationic antimony(V) metalloporphyrin derivatives on a clay layer surface.

    Science.gov (United States)

    Tsukamoto, Takamasa; Shimada, Tetsuya; Takagi, Shinsuke

    2013-08-22

    Three types of mono-, tri-, and penta-cationic antimony(V) porphyrin derivatives (Sb(V)Pors) were synthesized, and their photochemical properties on the anionic clay were systematically investigated. Sb(V)Por derivatives are dihydroxo(5,10,15,20-tetraphenylporphyrinato)antimony(V) chloride ([Sb(V)(TPP)(OH)2](+)Cl(-)), dihydroxo[5,10-diphenyl-15,20-di(N-methyl-pyridinium-4-yl)porphyrinato]antimony(V) trichloride ([Sb(V)(DMPyP)(OH)2](3+)3Cl(-)), and dihydroxo[5,10,15,20-tetrakis(N-methyl-pyridinium-4-yl)porphyrinato]antimony(V) pentachloride ([Sb(V)(TMPyP)(OH)2](5+)5Cl(-)). The photochemical behaviors of three cationic Sb(V)Pors with and without clay were examined in aqueous solution. For all Sb(V)Por, aggregation behaviors were not observed in the clay complexes even at high density adsorption conditions. The transition probabilities and fluorescence quantum yields of Sb(V)Por showed a tendency to be increased by the complex formation with clay. The less cationic Sb(V)Por/clay complex showed the larger fluorescence quantum yield. The more cationic Sb(V)Por/clay complex showed the longer fluorescence lifetime. These effects of complex formation with clay on the photochemical properties of Sb(V)Pors were discussed using the molecular potential energy curves of the porphyrin ground state and excited state. It is concluded that two types of effects work in the Sb(V)Por/clay system: effect i (structure resembling effect) is that the most stable structure becomes relatively similar between the ground and excited states, mainly by hydrophobic interactions between the porphyrin molecule and the clay surface, and effect ii (structure fixing effect) is that sharpened potential energy curves of clay complexes can lead to the increase of activation energy for the internal conversion from excited state to a high vibration level of ground state, mainly by electrostatic interactions between cationic porphyrin and anionic clay. Like this, the unique effects of the clay surface on

  5. La necropoli neolitica a domus de janas di S. Pietro di Sorres in Comune di Borutta - Sassari

    Directory of Open Access Journals (Sweden)

    Pier Paolo Soro

    2009-05-01

    Full Text Available La necropoli di Sorres si trova nel territorio del Comune di Borutta in provincia di Sassari. E’ ubicata lungo il versante SE del colle di Sorres, sul quale sorge imponente la chiesa in stile romanico di San Pietro di Sorres (XI-XII sec. sede dell’antica diocesi medievale. La necropoli è composta attualmente da cinque tombe a grotticella artificiale del tipo a domus de janas, scavate nella roccia calcara durante il neolitico recente ed in uso per tutto l’eneolitico. Si presume che fosse l’area sepolcrale dell’insediamento in grotta di Ulàri, una cavità carsica di notevoli dimensioni il cui ingresso si apre lungo il versante Nord del colle; la grotta ha restituito testimonianze archeologiche che vanno dal neolitico media fino al medioevo. La necropoli di Sorres, sebbene sia stata rimaneggiata nella forma degli ambienti ipogei e nella destinazione d’uso, costituisce una delle principali testimonianze del capillare tessuto insediativo del territorio del nord Sardegna.

  6. Possibilità di utilizzo agricolo di fertilizzanti di nuova formulazione derivanti da sotto prodotti del ciclo conciario

    OpenAIRE

    BERTOLDI, MARICA

    2009-01-01

    Il cromo, nella forma trivalente (CrIII)è un importante componente per la salute umana e animale, mentre il CrVI è altamente tossico e cancerogeno causando la morte se ingerito ad elevate dosi. Negli ultimi anni sono stati definiti i limiti accettabili del contenuto di cromo nei biosolidi o fanghi di conceria per una loro utilizzazione nel suolo in agricoltura. In questa ricerca si è studiato la possibilità di riutilizzo in agricoltura dei fanghi e di altri sottoprodotti del ciclo conciario c...

  7. Interpretazione matematico-statistica dei metodi di stima diretti

    Directory of Open Access Journals (Sweden)

    Gabriele Brondino

    2011-12-01

    Full Text Available Partendo dai presupposti dettati dai postulati estimativi dell’ordinarietà, della previsione e della comparazione, il legame tra la stima del Valore di Mercato e il Prezzo di Compravendita può essere spiegato da un punto di vista matematico. Il modello di Prezzo di Compravendita e un campione estimativo significativo sono strumenti centrali per lo sviluppo di uno dei qualsiasi metodi di stima diretti del Valore di Mercato. Obiettivo del presente studio è quello di descrivere le relazioni matematico-statistiche - nonché le difficoltà di applicazione – alla base dei metodi di stima diretti, prendendo spunto da casi studio pseudo-reali. Di seguito si prenderà quindi in considerazione un campione estimativo particolarmente numeroso e si fornirà una stima del Valore di Mercato del bene oggetto di stima attraverso la metodologia statistica nota come Regressione lineare multipla; si provvederà quindi ad applicare anche il cosiddetto Sales Comparison Approach (SCA per stimare il Valore di Mercato nel caso di un campione estimativo di bassa numerosità. Infine si valuterà l'utilità pratica e le condizioni di applicazioni di un metodo di stima noto come Nearest Neighbors Appraisal Technique (NNAT.

  8. menzogna e sortilegio, il primo romanzo di elsa morante

    African Journals Online (AJOL)

    User

    Il tono dei commentatori fu generalmente alquanto riservato, con un paio di eccezioni degne di nota ─ per la ferocia, non per l'entusiasmo, di certo. Di recensioni entusiastiche il lunghissimo romanzo non ne ebbe neppure una. In linea di massima i recensori sono piuttosto rispettosi del raffinato livello linguistico e stilistico ...

  9. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2004-06-01

    Full Text Available

    Report of PhD Dissertations.

    Francesco Barone

    Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Laura Berti Ceroni

    Il territorio e le strutture di Cesarea e Classe tra tarda antichità e alto medioevo in rapporto con Ravenna, Tesi di dottorato di ricerca in Storia e Informatica, Università degli studi di Bologna, 2002-2003.

     

    Marco Bicchierai

    Poppi dalla signoria dei conti Guidi al vicariato del Casentino (1360-1480, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Firenze, 2004

     

    Emanuela Garimberti

    Spatiosa ad habitandum loca. Luoghi e identità nella Historia Langobardorum di Paolo Diacono, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004

     

    Lorenzo Tanzini

    Sistemi normativi e pratiche istituzionali a Firenze dalla fine del XIII all’inizio del XV secolo, Tesi di dottorato di ricerca in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Stefania Tarquini

    Pellegrinaggio e asseto urbano di Roma, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo, Università degli studi di Lecce, 2003

    Segnalazione di tesi di dottorato.

    Francesco Barone

    Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Laura Berti Ceroni

  10. Fabrication and Application of Mono-sized Spherical Micro Particles by Pulsated Orifice Ejection Method

    Directory of Open Access Journals (Sweden)

    DONG Wei

    2018-02-01

    Full Text Available A novel technology called pulsated orifice ejection method(POEM and used for preparing mono-sized and high-precision spherical micro particles was introduced in this article. The working principle of the technique was illustrated and it was in two modes:low-melting point diaphragm mode and high-melting point rod mode, depending on the different melting points of materials. The particles prepared by POEM have the advantages of mono-sized, uniform and controllable particle size, high sphericity, and consistent thermal history. By introducing the application of particles prepared by this method, showing the huge application prospects of this technology in electronic packaging, bioengineering, micro-fabrication, rapid solidification analysis of metal droplets, additive manufacturing and so on.With the development of POEM, this technology is predicted to have wider prospects due to its unique characteristics.

  11. Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome.

    Science.gov (United States)

    Byun, Hyang-Min; Heo, Kyu; Mitchell, Kasey J; Yang, Allen S

    2012-02-02

    Retrotransposons have been extensively studied in plants and animals and have been shown to have an impact on human genome dynamics and evolution. Their ability to move within genomes gives retrotransposons to affect genome instability. we examined the polymorphic inserted AluYa5, evolutionary young Alu, in the progesterone receptor gene to determine the effects of Alu insertion on molecular environment. We used mono-allelic inserted cell lines which carry both Alu-present and Alu-absent alleles. To determine the epigenetic change and gene expression, we performed restriction enzyme digestion, Pyrosequencing, and Chromatin Immunoprecipitation. We observed that the polymorphic insertion of evolutionally young Alu causes increasing levels of DNA methylation in the surrounding genomic area and generates inactive histone tail modifications. Consequently the Alu insertion deleteriously inactivates the neighboring gene expression. The mono-allelic Alu insertion cell line clearly showed that polymorphic inserted repetitive elements cause the inactivation of neighboring gene expression, bringing aberrant epigenetic changes.

  12. Resurrecting an unsalvageable lower incisor with a mono-block approach

    Science.gov (United States)

    Jain, Rachit; Thomas, Manuel S.; Yadav, Amit

    2015-01-01

    Contemporary techniques, as well as the availability of bioactive and adhesive materials in endodontics, have helped revivifying teeth that were deemed hopeless. These newer materials and techniques would enable the clinician: (a) to predictably stop microbial activity (b) to achieve a total corono-apical fluid tight seal and (c) to strengthen mutilated teeth by obtaining intra-radicular reinforcement through mono-block effect. This case report demonstrates the successful treatment of a mutilated anterior tooth with the use of bioactive and adhesive materials to obtain a total seal and mono-block effect. This article also shows the use of a simple method in the placement of root filling cement into the root canal. PMID:26430310

  13. Macchine per giuoco nella proposta di Leopardi

    Directory of Open Access Journals (Sweden)

    Laura Neri

    2017-06-01

    Full Text Available Un’operetta morale di Leopardi, la Proposta di premi fatta dall’Accademia dei Sillografi, adotta il linguaggio tecnico di un bando di concorso per proporre tre premi agli inventori di tre macchine umane perfette: l’amicizia, la magnanimità, la fedeltà coniugale sono gli obiettivi delle invenzioni scientifiche. Il tono serio cela in realtà la  polemica contro l’antropocentrismo e soprattutto contro l’ottimismo del suo tempo.  One of Leopardi’s Operette morali, Proposta di premi fatta dall’Accademia dei Sillografi, adopts the gergon of a competition notice to propose three prizes to the inventors of three perfect human machines: friendship, magnanimity, conjugal fidelity are the aims of scientific inventions. The serious tone really conceals the controversy against anthropocentrism and above all against the optimism of its time.

  14. CATHEGORIZATION OF THE SPORT DI SCIPLINES

    Directory of Open Access Journals (Sweden)

    Duško Bjelica

    2007-05-01

    Full Text Available The pa per de als with the ca te go ri za tion of the spots di sci pli nes ac cor ding to the le vel of the bi o mot ho sric di men si ons. That kind of system wo uld con sist of 81 ca te go ri es which is not too much, con si de ring all the di sci pli nes. The re is a gre at num ber of the com pe ti ti ve di sci pli nes which ado not be long to the pro gram of the Olympic ga mes. The last Sum mer Olympic ga mes con si sted of 28 sports with 301 spot di sci pli nes, and the last Win ter Olympic ga mes con si sted of se ven sports with se venty eight sports di sci pli nes

  15. Analisi dell’utilizzo di Twitter nella costruzione di un seminario sperimentale

    Directory of Open Access Journals (Sweden)

    Wolfgang Reinhardt

    2013-03-01

    Full Text Available Nonostante i massicci cambiamenti sociali e tecnologici che si sono verificati a causa del Web negli ultimi anni, i corsi universitari spesso enfatizzano metodi di insegnamento da tempo consolidati e basati su strumenti di apprendimento e risorse tradizionali. Durante tali corsi gli studenti spesso acquisiscono una conoscenza che non è aggiornata e che è lontana da un apprendimento realistico, basato su problemi. L'uso di strumenti e metodi più recenti spesso rimane fuori dalla padronanza degli studenti. In questo contributo si descrive brevemente l’impostazione sperimentale di un seminario in due università tedesche dove l’uso di Social Media per la comunicazione e la collaborazione è stato saldamente integrato alla progettazione di un percorso di apprendimento formale. Si illustra, inoltre, l'utilizzo di Twitter durante il seminario, usando metodologie riprese dalla Social Network Analysis.

  16. New Mono- and Biaccelerator Iterative Methods with Memory for Nonlinear Equations

    Directory of Open Access Journals (Sweden)

    T. Lotfi

    2014-01-01

    Full Text Available Acceleration of convergence is discussed for some families of iterative methods in order to solve scalar nonlinear equations. In fact, we construct mono- and biparametric methods with memory and study their orders. It is shown that the convergence orders 12 and 14 can be attained using only 4 functional evaluations, which provides high computational efficiency indices. Some illustrations will also be given to reverify the theoretical discussions.

  17. Morphological and Spectral Characteristics of Hybrid Nanosystems Based on Mono- and Bimetallic Platinum Nanoparticles and Silver

    Science.gov (United States)

    Valueva, S. V.; Vylegzhanina, M. E.; Sukhanova, T. E.

    2018-02-01

    Morphological and spectral characteristics of hybrid nanosystems (NSes) based on mono- and bimetallic silver and platinum nanoparticles (NPs) stabilized by a cationic polyelectrolyte (CP), poly- N,N,N,N-trimethylmethacryloyloxyethylammonium methylsulfate, are determined via static/dynamic light scattering, UV spectroscopy, and atomic force microscopy. The formation of dense spherical polymolecular nanostructures is established. The possibility of controlling the morphological and spectral characteristics of the NS is shown by varying the nature and composition of NPs.

  18. Quantifying the efficiency of a mono-port diffuser in the dispersion of brine discharges

    OpenAIRE

    Loya-Fernández, Angel; Ferrero-Vicente, Luis Miguel; Marco-Méndez, Candela; Martinez-Garcia, Elena; Zubcoff, Jose; Sánchez-Lizaso, José Luis

    2018-01-01

    Reverse-osmosis seawater desalination processes produce a hypersaline effluent waste (brine) which is usually discharged back into the sea via an underwater outfall. Brine discharges can cause environmental problems due to their high salt concentration, but the effects can be minimised by installing a diffuser structure at the end of the pipeline. In May 2010, a mono-port diffuser was installed at the Nuevo Canal de Cartagena desalination plant pipeline (located in Murcia, Spain) in order to ...

  19. Screening for nonalcoholic steatohepatitis by using cytokeratin 18 and transient elastography in HIV mono-infection.

    Directory of Open Access Journals (Sweden)

    Amine Benmassaoud

    Full Text Available HIV-infected individuals are at high risk of developing nonalcoholic steatohepatitis (NASH, a leading cause of end-stage liver disease in Western countries. Nonetheless, due to the invasiveness of liver biopsy, NASH remains poorly understood in HIV mono-infection. We aimed to characterize the prevalence and predictors of NASH in unselected HIV mono-infected patients by means of non-invasive diagnostic tools.HIV-infected adults without significant alcohol intake or co-infection with hepatitis B or C underwent a routine screening program employing transient elastography (TE with controlled attenuation parameter (CAP and the serum biomarker cytokeratin-18 (CK-18. NASH was diagnosed non-invasively as the coexistence of fatty liver (CAP ≥248 dB/m and CK-18 >246 U/L. Identified cases of NASH were offered a diagnostic liver biopsy. Predictors of NASH were determined by multivariate logistic regression analysis.202 consecutive HIV mono-infected patients were included. NASH was non-invasively diagnosed in 23 cases (11.4%. Among them, 17 underwent a liver biopsy, and histology confirmed NASH in all cases. The prevalence of NASH was higher in patients with hypertriglyceridemia (17.1%, insulin resistance defined by homeostasis model for assessment of insulin resistance (HOMA-IR (25%, those with detectable HIV viral load (42.9% and those with elevated ALT (53.6%. After adjustment, higher HOMA-IR (adjusted odds ratio [aOR] = 1.20, 95% CI 1.01-1.43; p = 0.03 and ALT (aOR = 2.39, 95% CI 1.50-3.79; p<0.001 were independent predictors of NASH.NASH, diagnosed by a non-invasive diagnostic approach employing CK-18 and TE with CAP, is common in unselected HIV mono-infected individuals, particularly in the presence of insulin resistance and elevated ALT.

  20. Heavy metals behaviour during mono-combustion and co-combustion of sewage sludge

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, M. Helena; Abelha, Pedro; Olieveira, J.F. Santos; Gulyurtlu, Ibrahim; Cabrita, Isabel [INETI-DEECA, Lisboa (Portugal)

    2005-03-01

    This paper presents the study of the combustion of granular dry sewage sludge performed on a pilot fluidized bed system. The results of mono-combustion of sludge and co-combustion with coal were compared with those of coal combustion for ash partitioning, the formation of gaseous pollutants and heavy metals behaviour. It was found that the mineral matter of sludge was essentially retained as bottom ashes. The production of fines ashes was small during the mono-combustion due to the tendency of coal to produce fine ashes which also contained unburned char. The degree of heavy metal volatilization was found to be slightly higher during co-combustion than in mono-combustion; however, most of them were retained in ashes and their emissions were found to be below the regulated levels. Hg was completely volatilized; however, during combustion trials involving coal it was captured by cyclone ashes at temperatures below 300 deg C. During sludge mono-combustion the retention of Hg in cyclone ashes containing low LOI was not enough to decrease emissions below the regulated levels; hence, it is necessary to install dedicated flue gas treatment for Hg removal. The leachability and ecotoxicity of sludge and ashes was compared with the new regulatory limits for landfill disposal in the EU. It was found that the release of organic matter and heavy metals found in the sludge was low from granular bed ashes; hence, except for sulphate release, bed ashes were converted into inert and non-ecotoxic materials. Ashes from test with limestone and cyclone ashes seemed to be more problematic because of pH effects and contamination with steel corrosion products. The recovery and reutilization of sludge bed ashes could, therefore, be possible, as long as the release of sulphate do not interfere with the process.

  1. Finite-dimensional output feedback regulator for a mono-tubular heatexchanger process

    OpenAIRE

    Xu, Xiaodong; Dubljevic, Stevan

    2016-01-01

    In this work, we consider the output tracking and disturbance rejection problems of a mono-tubular heat exchanger process and a novel finite-dimensional output feedback regulator is developed. In the proposed output feedback regulator design, measurements available for the regulator do not belong to the set of controlled outputs. In other words, design emphasizes that other than controlled output is used as input signal to the regulator. The proposed output feedback regulator with only plant ...

  2. Asynchronous Replication, Mono-Allelic Expression, and Long Range Cis-Effects of ASAR6

    OpenAIRE

    Donley, Nathan; Stoffregen, Eric P.; Smith, Leslie; Montagna, Christina; Thayer, Mathew J.

    2013-01-01

    Mammalian chromosomes initiate DNA replication at multiple sites along their length during each S phase following a temporal replication program. The majority of genes on homologous chromosomes replicate synchronously. However, mono-allelically expressed genes such as imprinted genes, allelically excluded genes, and genes on female X chromosomes replicate asynchronously. We have identified a cis-acting locus on human chromosome 6 that controls this replication-timing program. This locus encod...

  3. Charge transport and storage of low programming voltage SONOS/MONOS memory devices

    Science.gov (United States)

    Libsch, Frank R.; White, Marvin H.

    1990-01-01

    In this paper, a model based on two carrier conduction (electrons and holes) at both injecting boundaries (semiconductor bulk and gate electrode) is introduced to interpret the ERASE/WRITE characteristics of scaled SONOS devices. The amphoteric statistics describe the positive and negative charging of the deep-level traps in the nitride "memory" layer. Scaled SONOS/MONOS (polysilicon-oxide-nitride-oxide-semiconductor)/(metal-oxide- nitride-oxide-semiconductor) transistors and capacitors with the bottom ('tunnel') oxide layer thickness around 20 Å, the final nitride layer thickness below 100 Å, and the top ('blocking') oxide layer thickness between 35-50 Å, have been fabricated and characterized. The results of the model are consistent with the experimental data, which permits physical insight into the mechanisms of charge injection, transport and storage during the ERASE/WRITE operation. Lattice imaging electron microscopy (TEM), ellipsometry, electrical capacitance, and chemical etchback techniques have been used to determine scaled SONOS/MONOS material parameters. The linear voltage ramp technique, which simultaneously measures the flatband voltage shift and separates the charges at the injecting boundary, and the dynamic pulse techniques of flatband tracking and threshold monitoring, which measure ERASE/WRITE, retention and endurance operations, have been employed to electrically characterize the scaled SONOS/MONOS devices. We have demonstrated a differential, saturated ERASE/WRITE flatband shift of 3.8 V with a ±5 V programming voltage for scaled-down SONOS/MONOS devices with dimensions of 20 Å for the tunnel oxide, 50 Å for the nitride, and 35 Å for the blocking oxide. With ±5 V saturated ERASE/WRITE programming voltages and 10 6 ERASE/WRITE cycles, extrapolated retention gives a projected 10 year 0.5 V memory window at room temperature.

  4. Mono-implicit Runge Kutta schemes for singularly perturbed delay differential equations

    Science.gov (United States)

    Rihan, Fathalla A.; Al-Salti, Nasser S.

    2017-09-01

    In this paper, we adapt Mono-Implicit Runge-Kutta schemes for numerical approximations of singularly perturbed delay differential equations. The schemes are developed to reduce the computational cost of the fully implicit method which combine the accuracy of implicit method and efficient implementation. Numerical stability properties of the schemes are investigated. Numerical simulations are provided to show the effectiveness of the method for both stiff and non-stiff initial value problems.

  5. SIMAC - A phosphoproteomic strategy for the rapid separation of mono-phosphorylated from multiply phosphorylated peptides

    DEFF Research Database (Denmark)

    Thingholm, Tine E; Jensen, Ole N; Robinson, Phillip J

    2008-01-01

    spectrometric analysis, such as immobilized metal affinity chromatography or titanium dioxide the coverage of the phosphoproteome of a given sample is limited. Here we report a simple and rapid strategy - SIMAC - for sequential separation of mono-phosphorylated peptides and multiply phosphorylated peptides from...... and an optimized titanium dioxide chromatographic method. More than double the total number of identified phosphorylation sites was obtained with SIMAC, primarily from a three-fold increase in recovery of multiply phosphorylated peptides....

  6. Constraining Dark Matter using Mono-X, Dijet, and Dilepton Final States with the ATLAS Detector

    CERN Document Server

    Tolley, Emma; The ATLAS collaboration

    2017-01-01

    Weakly-coupled TeV-scale particles may mediate interactions between dark matter (DM) and Standard Model (SM) particles. DM production at colliders may be evident in “mono-X” topologies, and mediator production in in dijet and dilepton events. The latest results obtained by the ATLAS experiment are presented and interpreted following the LHC DM WG guidelines, with particular focus on the complementarity between different collider searches as well as direct detection experiments.

  7. Dark Matter Searches with Mono-X Signatures at the ATLAS Experiment

    CERN Document Server

    Tolley, Emma; The ATLAS collaboration

    2016-01-01

    At the LHC dark matter particles can be produced in association with other particles which mainly come from initial state radiation. Searches for such processes are presented using events with jets, photons or massive gauge bosons recoiling against large missing transverse momentum in ATLAS at 13 TeV. These “mono-X” signatures provide powerful probes to dark matter production at the LHC, allowing to interpret results in terms of simplified models with pair production of WIMPs.

  8. Dark Matter searches with Mono-X signatures at the ATLAS experiment

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00377126; The ATLAS collaboration

    2016-01-01

    At the LHC dark matter particles can be produced in association with Standard Model particles coming from initial state radiation. Searches for such processes using events with jets, photons or massive gauge bosons recoiling against large missing transverse momentum in ATLAS at 13 TeV are presented. These ``mono-X'' signatures provide powerful probes to dark matter production at the LHC, allowing for the interpretation of results in terms of simplified models with pair production of WIMPs.

  9. Nest site selection by greater sage-grouse in Mono County, California

    Science.gov (United States)

    Kolada, Eric J.; Sedinger, James S.; Casazza, Michael L.

    2009-01-01

    Loss of nesting habitat is believed to be a factor in the decline of greater sage-grouse (Centrocercus urophasianus) throughout its range. Few data are available for sage-grouse in Mono County, California, USA, in the most southwestern portion of the species' range. We studied habitat selection of nesting sage-grouse in Mono County, California, from 2003 to 2005 by capturing and radiotracking females to identify nesting locations. We sampled vegetation at nest sites and randomly selected sites within 200 m of nests and within each of 5 subareas within Mono County. Nest sites were characterized by 42.4 ± 1.3% (x ¯ ± SE) shrub canopy cover, 10.5 ± 1.0 cm residual grass height, and 2.7 ± 1.0% residual grass cover. Shrub cover was the only variable found to differentiate nest sites from randomly selected sites. Unlike some other studies, we did not find understory vegetation to be important for selecting nest sites. Mean shrub cover was 38.7 ± 1.5% at random sites within 200 m of nests and 33.6 ± 1.6% at random sites at the approximate scale of home ranges, indicating that nesting females selected nesting areas that contained denser shrubs than their home range, and nest sites that contained greater shrub cover than the vicinity immediately surrounding nests. Our results suggest that managers should consider managing for greater shrub cover in Mono County than what is currently called for in other parts of sage-grouse range and that management for sage-grouse habitat may need to be tied more closely to local conditions.

  10. Stereoselective mannich reactions of mono thiomalonates : & screening for peptidic triazolium salt based catalysts

    OpenAIRE

    Bahlinger, Annette

    2014-01-01

    Part I: The stereoselective synthesis of ß-amino thioesters is of high interest since they are versatile and common building blocks for a variety of pharmaceutically important compounds. Within this thesis a mild organocatalyzed approach for the synthesis of ß-amino thioesters by using mono thiomalonates (MTMs) as thioester enolate equivalents was developed. Those nucleophiles proved to be highly reactive in Mannich reactions providing for acyclic ß2-amino thioesters and ß2,3,3-amino thioeste...

  11. Analisi dell'efficacia di un programma di prevenzione secondaria del carcinoma orale

    Directory of Open Access Journals (Sweden)

    S. Iannazzo

    2003-05-01

    Full Text Available

    In Italia i carcinomi del cavo orale (KCO sono diagnosticati
    prevalentemente al II-IV stadio TNM con conseguenti basse sopravvivenza a 5 anni e qualità della vita. Una maggior frequenza di diagnosi allo stadio I porterebbe a migliorare ampiamente i valori medi dei suddetti parametri.
    Scopo del presente lavoro è stato valutare l’efficacia di un programma di prevenzione secondaria del KCO in termini di aumento di diagnosi allo stadio I e di vite salvate.

    Abbiamo stimato la prevalenza di casi istopatologicamente
    accertati (livello C3 di leucoplachia, principale lesione precancerosa del KCO, nella ASL/RMA come prodotto tra la prevalenza stimata di leucoplachia diagnosticata clinicamente (livello C2 (2989,2Ĩ13077,7 e la proporzione, scelta arbitrariamente, di C3 tra i C2 (0,50.

    Tenendo presente che nel campione studiato nella ASL/RMA la proporzione di KCO allo stadio I tra i C3 era 0,03, abbiamo stimato il numero di KCO.

    Abbiamo stimato quanti KCO verrebbero diagnosticati allo stadio I se venisse attuato un programma di prevenzione secondaria, considerando diversi livelli di compliance, e sulla base di una sopravvivenza media a 5 anni, in Italia, del 53% per tutti gli stadi e del 79% per i KCO allo stadio I, abbiamo calcolato il numero di vite salvate. I valori sono stati espressi come IC95.

    Le prevalenze di leucoplachia C3 e KCO sono risultate,
    rispettivamente, 1494,6Ĩ6538,8 e 44,8Ĩ196,2. Con compliance del 10%, 40% e 75% verrebbero diagnosticati, rispettivamente, 4,5Ĩ19,6, 17,9Ĩ78,5 e 33,6Ĩ147,2 casi di KCO e le vite salvate sarebbero 1,1Ĩ5,1, 4,6Ĩ20,4 e 8,7Ĩ38,3 rispettivamente.
    In termini di vite salvate i dati evidenziano la necessita di attuare programmi di screening del KCO, anche nell' eventualità di uno scarso coinvolgimento della popolazione a rischio.

  12. Perancangan Promosi Amelia Cake & Bakery Di Surabaya

    OpenAIRE

    Cahyono, Susanti Aprillia; Bramantya, Bramantya; Sutanto, Ryan

    2015-01-01

    Amelia Cake & Bakery meupakan sebuah bakery di Surabaya yang sudah berdiri sejak tahun 1984. Amelia Cake& Bakery memiliki beberapa produk andalan di antaranya Spikoe Resep Kuno, Walnut Cake, Pandan Kukus, danMascovis Cake. Tidak adanya promosi yang dilakukan oleh Amelia Cake & Bakery membuat bakery ini kurangdi kenal di kota Surabaya. Dengan adanya perancangan promosi ini diharapkan dapat membuat Amelia Cake &Bakery dikenal dan mampu bersaing dengan kompetitor-kompetitornya.

  13. HASILTANGKAPANTERIPANG(Sea cucumber) DI PERAIRANKARANGSCOTTPULAUDATUAUSTRALIA

    OpenAIRE

    Anthony Sisco Panggabean; Ralph Thomas Mahulette; Jim Prescott

    2016-01-01

    Perairan karang Scott (Scott Reef) yang terletak disekitar Pulau Datu berada di Perairan Laut Timor – Australia khususnya di lokasi MoU Box 74. Banyak nelayan tradisional Indonesia yang berasal dari Pulau Rote Alor dan Madura menangkap teripang di kawasan tersebut sebagai mata pencahariannya secara turun temurun. Suatu penelitian merupakan kerjasama antara Pemerintah Indonesia (Badan Penelitian dan Pengembangan Kelautan dan Perikanan) dan Pemerintah Australia (Australian Fisheries Management ...

  14. Kajian Pengembangan Mebel Rotan di Sumbawa Barat

    OpenAIRE

    Edi Eskak

    2016-01-01

    ABSTRAKRotan merupakan hasil hutan yang melimpah di Sumbawa Barat sehingga mempunyai potensi yang besar untuk pengembangan industri mebel rotan. Di Sumbawa Barat saat ini tidak terdapat industri pengolahan rotan asalan menjadi iratan dan pitrit, sebagai bahan anyaman untuk mebel. Tujuan kajian ini adalah untuk mencari solusi pengembangan mebel rotan di Sumbawa Barat yang bahan bakunya masih berupa rotan asalan yaitu berupa rotan batangan menjadi produk mebel. Metode yang digunakan yaitu deskr...

  15. Demonstration of bioprocess factors optimization for enhanced mono-rhamnolipid production by a marine Pseudomonas guguanensis.

    Science.gov (United States)

    C, RamyaDevi K; R, Lakshmi Sundaram; D, Asha; V, Sivamurugan; Vasudevan, Vidya; Krishnan, Mary Elizabeth Gnanambal

    2018-03-01

    We identified that Pseudomonas guguanensis produced macromolecular mono-rhamnolipid (1264.52 Da) upon sensing n-hexadecane/diesel/kerosene from its surroundings. Permutation experiments were done to improve the laboratory-scale mono-rhamnolipid production (ie, a three-fold increase) using RSM validation. Consequently, maximal mono-rhamnolipids production [40-50 mg/L] and emulsification abilities [65-70%] were encountered on day 8 using vegetable oil, peptone + yeast extract. EI 24 values for the rhamnolipids were found to be 78±1.75% at 12.5 mg/ mL. Production and secretion of rhamnolipids were accompanied by aggregation of cells at day 6 as pictured in SEM. Pure monorhamnolipids of P. guguanensis was found to lower the surface tension of water to 32.98±0.3 mN/m than the crude and CFSs of P. aeruginosa indicating efficient activity. Utilization and subsequent removal of hexadecane was 77.2% and the breakdown products were fatty acids [decanoic, hexadecanoic, octadecanoic acids and methyl stearates] as signified in Head-space GC-MS. The breakdown products of hexadecane are also present in the synthesized rhamnolipids suggesting their biosynthetic role. Rapid degradation of hexadecane, diesel and kerosene by this emulsifier combined with non-pathogenic trait of P. guguanensis identifies this organism as a viable option to remove n-alkanes from aquatic environments. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Absolute palaeointensity study of the Mono Lake excursion recorded by New Zealand basalts

    Science.gov (United States)

    Cassidy, John; Hill, Mimi J.

    2009-02-01

    One of the geomagnetic excursions recorded in basalts of the Auckland volcanic field, New Zealand, has recently been correlated unequivocally with the Mono Lake excursion, making it the only confirmed record from the southern hemisphere. This record is also exceptional in occurring in five separate monogenetic basaltic volcanoes. Absolute palaeointensity determinations using the microwave technique, based on a comprehensive suite of samples of the Auckland basalts recording the excursion, show that the geomagnetic field in New Zealand at the time of the Mono Lake excursion was reduced to about 14 μT i.e. to 30% of its normal value. This result confirms previous estimates based on more limited sampling. In addition, it provides a comparison of the microwave and LDT-DHT Shaw methods of measuring palaeointensity, which give results that are statistically indistinguishable. The palaeointensities determined from the five different volcanoes are also indistinguishable, though the palaeodirection data suggest that a very small segment of the VGP path may have been recorded. This study confirms the reliability of palaeointensity and palaeodirection determinations from these particular New Zealand basalts, which together with their definitive 40Ar/ 39Ar ages, establishes this record of the Mono Lake excursion as one of the best documented. Consequently, there is significant potential in searching for records of this excursion elsewhere in the Pacific region for use as a stratigraphic marker in studies of recent volcanism and palaeoclimate reconstructions.

  17. Assessment of genetic diversity and variation of acer mono max seedlings after spaceflight

    International Nuclear Information System (INIS)

    Long, C.; Li, Y.; Zhang, Y.; Yang, M.

    2015-01-01

    Genetic diversity and variation of Acer Mono Maxim seedlings sampled from space-mutated (sm) populations were compared to seedlings from parallel control (ck) ones using molecular markers. RAMP analysis showed that the percentage of polymorphic band, Shannon diversity index and Nei gene diversity index of the space-mutated populations were higher than those of the control ones, which indicated that genetic variation increased after spaceflight in populations of Acer Mono Maxim. By using un-weighted pair group method with arithmetic mean (UPGMA) method, three space-mutated repeats (populations) were clustered together, and control groups clustered separately, which further indicated that there was difference between the space-mutated ones and the control ones, which may be caused by space mutation. Further analysis of genomic inconsistency between the root and leaf samples from the same tree showed that a total variation rate of 6.3% and 1.7% were obtained in ten space-mutated individuals by using RAMP and SSR markers, respectively, however, the variation rate was zero in control ones. It provided that space mutation may be caused the individual variation of Acer Mono Maxim. (author)

  18. Geochemical fingerprinting of Wilson Creek formation tephra layers (Mono Basin, California) using titanomagnetite compositions

    Science.gov (United States)

    Marcaida, Mae; Mangan, Margaret T.; Vazquez, Jorge A.; Bursik, Marcus; Lidzbarski, Marsha I.

    2014-01-01

    Nineteen tephra layers within the Wilson Creek formation near Mono Lake provide a record of late Pleistocene to early Holocene volcanic activity from the nearby Mono Craters and are important chronostratigraphic markers for paleomagnetic, paleoclimatic, and paleoecologic studies. These stratigraphically important tephra deposits can be geochemically identified using compositions of their titanomagnetite phenocrysts. Titanomagnetite compositions display a broad range (XUsp 0.26–0.39), which allow the tephra layers to be distinguished despite the indistinguishable major-element glass compositions (76–77 wt% SiO2) of their hosts. The concentrations of Ti and Fe in titanomagnetite display geochemical and stratigraphic groupings that allow clear discrimination between older (> 57 ka) and younger (2O3 contents. In addition, a few tephra layers can be correlated to their source vents by their titanomagnetite compositions. The unique geochemical fingerprint of the Mono Craters-sourced titanomagnetites also allows the discrimination of two tephra layers apparently sourced from nearby Mammoth Mountain volcano in Long Valley.

  19. p-Type Quasi-Mono Silicon Solar Cell Fabricated by Ion Implantation

    Directory of Open Access Journals (Sweden)

    Chien-Ming Lee

    2013-01-01

    Full Text Available The p-type quasi-mono wafer is a novel type of silicon material that is processed using a seed directional solidification technique. This material is a promising alternative to traditional high-cost Czochralski (CZ and float-zone (FZ material. Here, we evaluate the application of an advanced solar cell process featuring a novel method of ion implantation on p-type quasi-mono silicon wafer. The ion implantation process has simplified the normal industrial process flow by eliminating two process steps: the removal of phosphosilicate glass (PSG and the junction isolation process that is required after the conventional thermal POCl3 diffusion process. Moreover, the good passivation performance of the ion implantation process improves Voc. Our results show that, after metallization and cofiring, an average cell efficiency of 18.55% can be achieved using 156 × 156 mm p-type quasi-mono silicon wafer. Furthermore, the absolute cell efficiency obtained using this method is 0.47% higher than that for the traditional POCl3 diffusion process.

  20. Correlates of Mono- and Dual-Victims of Cybergrooming and Cyberbullying: Evidence from Four Countries.

    Science.gov (United States)

    Wachs, Sebastian; Whittle, Helen C; Hamilton-Giachritsis, Catherine; Wolf, Karsten D; Vazsonyi, Alexander T; Junger, Marianne

    2018-02-01

    Today's adolescents grow up using information and communication technologies as an integral part of their everyday life. This affords them with extensive opportunities, but also exposes them to online risks, such as cybergrooming and cyberbullying victimization. The aims of this study were to investigate correlates of cybergrooming and cyberbullying victimization and examine whether victims of both cybergrooming and cyberbullying (dual-cybervictims) show higher involvement in compulsive Internet use (CIU) and troubled offline behavior (TOB) compared to victims of either cybergrooming or cyberbullying (mono-cybervictims). The sample consisted of 2,042 Dutch, German, Thai, and U.S. adolescents (age = 11-17 years; M = 14.2; SD = 1.4). About every ninth adolescent (10.9 percent) reported either mono- or dual-cybervictimization. Second, both CIU and TOB were associated with all three types of cybervictimization, and finally, both CIU and TOB were more strongly linked to dual-cybervictimization than to both forms of mono-cybervictimization. These findings contribute to a better understanding of the associations between different forms of cybervictimization and psychological health and behavior problems among adolescents.

  1. Intra-articular osteoid osteoma as a differential diagnosis of diffuse mono-articular joint pain.

    Science.gov (United States)

    Rolvien, Tim; Zustin, Jozef; Mussawy, Haider; Schmidt, Tobias; Pogoda, Pia; Ueblacker, Peter

    2016-11-04

    The aim of this retrospective study was to investigate the frequency of intra-articular osteoid osteoma (iaOO) in a large study cohort and to demonstrate its clinical relevance as an important differential diagnosis of non-specific mono-articular joint pain. We searched the registry for bone tumours of the University Medical Centre Hamburg-Eppendorf for osteoid osteomas in the last 42 years. Herein, we present three selected iaOO which were detected in the three major weight-bearing joints. Computed tomography (CT) or magnetic resonance imaging (MRI) scans were performed for initial diagnosis. Out of a total of 367 osteoid osteomas, 19 (5.2 %) tumours were localized intra-articularly. In all three presented tumours, a history of severe mono-articular pain was reported; however, the mean time to correct diagnosis was delayed to 20.7 months. Clearly, the nidus seen in CT and MRI images in combination with inconsistent salicylate-responsive nocturnal pain led to the diagnosis of iaOO. Rarely, osteoid osteoma can occur in an intra-articular location. In cases of diffuse mono-articular pain, iaOO should be considered both in large and smaller joints to avoid delays in diagnosis and therapy of this benign bone tumour.

  2. Anaerobic mono-digestion of lucerne, grass and forbs – Influence of species and cutting frequency

    DEFF Research Database (Denmark)

    Wahid, Radziah; Feng, Lu; Cong, Wenfeng

    2018-01-01

    but it was not possible to ascertain whether this was due to organic overload alone or if high ammonia levels during Lu-4 digestion were contributing to the reduced performance. It was found that four cuts per year was suitable for a lab-scale mono-digestion system as the substrate was less fibrous and has lower dry......In the present study, biogas potentials of multispecies swards including grass, lucerne, caraway, ribwort plantain and chicory from two- and four-cut regimes (Mix-2 and Mix-4) for mono-digestion applying batch and continuous modes under lab-scale conditions were investigated. The gas yields...... confirmed with continuous experiments, during which the reactor digesting Mix-4 was stable throughout the experiment with low ammonia and volatile fatty acid (VFA) concentration. Meanwhile, mono-digestion of Lu-4 led to elevated VFA levels, even at a comparatively low organic loading rate of 1.76 g L−1 d−1...

  3. Controlled modification of mono- and bilayer graphene in O2, H2 and CF4 plasmas

    International Nuclear Information System (INIS)

    Felten, A; Pireaux, J-J; Eckmann, A; Casiraghi, C; Krupke, R

    2013-01-01

    In this work, covalent modification of mono- and bilayer graphene is achieved using tetrafluoromethane (CF 4 ), oxygen and hydrogen RF plasma. Controlled modification of graphene is usually difficult to achieve, in particular with oxygen plasma, which is rather aggressive and usually leads to etching of graphene. Here we use x-ray photoelectron spectroscopy and Raman spectroscopy to show that mild plasma conditions and fine tuning of the number of functional groups can be obtained in all plasmas by varying parameters such as exposure time and sample position inside the chamber. We found that even for the usual harsh oxygen treatment the defect density could be lowered, down to one defect for 3.5 × 10 4 carbon atoms. Furthermore, we show that CF 4 plasma leads to functionalization without etching and that graphene becomes an insulator at saturation coverage. In addition, the reactivity of mono- and bilayer graphene was studied revealing faster modification of monolayer in oxygen and CF 4 plasma, in agreement with previous works. In contrast, similar modification rates were observed for both mono- and bilayer during hydrogenation. We attribute this discrepancy to the presence of more energetic species in the hydrogen plasma such as positive ions that could play a role in the functionalization process. (paper)

  4. Controlled modification of mono- and bilayer graphene in O2, H2 and CF4 plasmas

    Science.gov (United States)

    Felten, A.; Eckmann, A.; Pireaux, J.-J.; Krupke, R.; Casiraghi, C.

    2013-09-01

    In this work, covalent modification of mono- and bilayer graphene is achieved using tetrafluoromethane (CF4), oxygen and hydrogen RF plasma. Controlled modification of graphene is usually difficult to achieve, in particular with oxygen plasma, which is rather aggressive and usually leads to etching of graphene. Here we use x-ray photoelectron spectroscopy and Raman spectroscopy to show that mild plasma conditions and fine tuning of the number of functional groups can be obtained in all plasmas by varying parameters such as exposure time and sample position inside the chamber. We found that even for the usual harsh oxygen treatment the defect density could be lowered, down to one defect for 3.5 × 104 carbon atoms. Furthermore, we show that CF4 plasma leads to functionalization without etching and that graphene becomes an insulator at saturation coverage. In addition, the reactivity of mono- and bilayer graphene was studied revealing faster modification of monolayer in oxygen and CF4 plasma, in agreement with previous works. In contrast, similar modification rates were observed for both mono- and bilayer during hydrogenation. We attribute this discrepancy to the presence of more energetic species in the hydrogen plasma such as positive ions that could play a role in the functionalization process.

  5. Controlled modification of mono- and bilayer graphene in O₂, H₂ and CF₄ plasmas.

    Science.gov (United States)

    Felten, A; Eckmann, A; Pireaux, J-J; Krupke, R; Casiraghi, C

    2013-09-06

    In this work, covalent modification of mono- and bilayer graphene is achieved using tetrafluoromethane (CF₄), oxygen and hydrogen RF plasma. Controlled modification of graphene is usually difficult to achieve, in particular with oxygen plasma, which is rather aggressive and usually leads to etching of graphene. Here we use x-ray photoelectron spectroscopy and Raman spectroscopy to show that mild plasma conditions and fine tuning of the number of functional groups can be obtained in all plasmas by varying parameters such as exposure time and sample position inside the chamber. We found that even for the usual harsh oxygen treatment the defect density could be lowered, down to one defect for 3.5 × 10⁴ carbon atoms. Furthermore, we show that CF₄ plasma leads to functionalization without etching and that graphene becomes an insulator at saturation coverage. In addition, the reactivity of mono- and bilayer graphene was studied revealing faster modification of monolayer in oxygen and CF₄ plasma, in agreement with previous works. In contrast, similar modification rates were observed for both mono- and bilayer during hydrogenation. We attribute this discrepancy to the presence of more energetic species in the hydrogen plasma such as positive ions that could play a role in the functionalization process.

  6. Electrospun decyl-3-methylimidazolium mono bromate/polyamide nanofibers as solid-phase microextraction coating.

    Science.gov (United States)

    Roostaie, Ali; Rastegar, Sorosh; Najarzadegan, Hamid; Ehteshami, Shokooh

    2017-09-22

    In the current study, electrospun-based ionic liquid (IL) doped polyamide (PA) nanofibers were prepared and used as the coating material of solid phase microextration device in the fiber geometry. Addition of IL, decyl-3-methylimidazolium mono bromate, increased the conductivity of the PA solution facilitating the electrospining process. The scanning electron microscopy images of decyl-3-methylimidazolium mono bromated/polyamide nanofibers showed the decreased diameter of the nanofibers in the range of 35-160nm compared to the PA nanofiber. The factors affecting the structure of nanofibers (e.g. ratio of decyl-3-methylimidazolium mono bromate to PA, coating time and applied voltage) were studied. In addition, influential parameters of extraction/desorption performance such as ionic strength, extraction time, and desorption time and temperature were studied. The limit of detections and limit of quantifications were obtained in the range of 0.75-0.9 and 2-5ngL -1 , respectively, demonstrating high efficiency of the prepared nanofiber. The developed method also showed good repeatability, RSD 4-9% (n=3), for the spiked aqueous solution at concentration level 150ngL -1 of chlorobenzenes, and linearity,R=0.996, in the range of 5-5000ngL -1 . Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Fleeing War. Due strategie di diserzione letteraria:I parenti del Sud di Carlo Montella e Going After Cacciato di Tim O’Brien

    Directory of Open Access Journals (Sweden)

    Giulio Segato

    2014-10-01

    Full Text Available Il saggio indaga due diverse strategie di diserzione rappresentate in due romanzi di guerra: I parenti del sud di Carlo Montella e Going After Cacciato di Tim O’Brien. Nelle due opere analizzate la diserzione sembra essere collegata al conflitto che fa da sfondo al romanzo. Nel libro di Montella,il protagonista, ancora obnubilato dalle dottrine tautologiche fasciste, qualche settimana dopo l’armistizio di Cassibile decide di disertare e di fuggire nella villa di un’anziana parente, con lo scopo di rinsavire dall’ideologia del regime. Nel romanzo di O’Brien, invece, la fuga messa in scena dall’autore sembra avere gli stessi tratti grotteschi e assurdi del conflitto in cui è stato catapultato il protagonista,la Guerra del Vietnam.

  8. Sviluppo e valutazione di test diagnostici per la sierodiagnosi di brucellosi suina

    Directory of Open Access Journals (Sweden)

    Tiziana Di Febo

    2012-06-01

    Full Text Available Sono stati sviluppati una ELISA competitiva (c-ELISA, una ELISA indiretta (i-ELISA e un test immunologico DELFIA (Dissociation-Enhanced Lanthanide Fluorescence Immunoassay per la ricerca di anticorpi verso Brucella suis in sieri di maiale e cinghiale. I tre test prevedono l’utilizzo di un anticorpo monoclonale (MAb 4B5A verso l’LPS di Brucella (c-ELISA e DELFIA e di un anticorpo monoclonale (MAb 10C2G5 verso le IgG suine (i-ELISA. La specificità (Sp e la sensibilità (Se dei tre test sono le seguenti: per la c-ELISA Se e Sp = 100% con un valore di cut-off pari al 61.0% (B/B0%; per la i-ELISA Sp = 99.1% e Se = 100% con un valore di cut-off di 21.7% (PP%; per il DELFIA Sp = 91.0% e Se = 75% ponendo il valore di cut-off al 37.0% (B/B0%. Inoltre sono state valutate le performance, nei confronti di sieri suini, di un test FPA (Fluorescence Polarization Assay commerciale sviluppato per la ricerca di anticorpi anti-Brucella in sieri bovini; la specificità e la sensibilità ottenute sono entrambe del 100% al valore di cut-off di 99.5 (mP. Questi risultati suggeriscono che la combinazione di c-ELISA, i-ELISA e FPA può essere utilizzata per migliorare la diagnosi di brucellosi suina.

  9. Matrimonio omosessuale e pubblico ufficiale: una nuova forma di obiezione di coscienza?

    Directory of Open Access Journals (Sweden)

    Ludovica Decimo

    2015-10-01

    SOMMARIO: 1. La difesa dei valori culturali e religiosi attraverso il diritto all’obiezione di coscienza - 2. I casi di obiezione di coscienza sulle unioni omosessuali: uno sguardo d’insieme oltre i confini nazionali - 3. Il matrimonio omosessuale e il pubblico ufficiale nell’ordinamento giuridico italiano - 4. Lo scudo dell’obiezione di coscienza: un’opzione possibile per il pubblico ufficiale?

  10. Analisis Faktor-Faktor Yang Mempengaruhi Konsumen Dalam Memutuskan Untuk Menginap Di Green Hotel Di Surabaya

    OpenAIRE

    Loppies, Alfredo Karsten; Nugroho, Steven Adi; Jokom, Regina

    2016-01-01

    Penelitian ini dilakukan untuk mengetahui faktor – faktor yang mempengaruhi konsumen dalam memutuskan untuk menginap di green hotel di Surabaya. Populasi adalah seluruh konsumen yang pernah menginap di hotel yang tergolong green hotel di Surabaya minimal sekali dalam kurun waktu 6 bulan terakhir dengan sampel penelitian berjumlah 168 responden. Teknik analisa yang digunakan dalam penelitian ini adalah analisa faktor untuk mereduksi sejumlah faktor internal dan eksternal yang mempengaruhi per...

  11. Valutazione quali – quantitativa di patata allevata con tecnica di produzione biologica e convenzionale

    OpenAIRE

    Tamburrino, Raffaele

    2006-01-01

    La qualità delle produzioni orticole è senza dubbio il principale obbiettivo dell’agricoltura moderna. Tuttavia il concetto di qualità rimane di non facile definizione. In Italia, dal secondo dopoguerra ad oggi, il concetto di qualità degli ortaggi per il consumo fresco ha subito una profonda evoluzione. Dai parametri di qualità strettamente commerciali ed organolettici, il concetto si è allargato fino a raggiungere un ambito ampio ed articolato che spazia dalle caratteristiche igienico-sanit...

  12. The use of approximation formulae in calculations of acid-base equilibria-I Mono- and diprotic acids and bases.

    Science.gov (United States)

    Narasaki, H

    1979-07-01

    The pH of mono- and diprotic acids is calculated by use of approximation formulae and the theoretically exact equations. The regions for useful application of the approximation formulae (error <0.02 pH) have been identified.

  13. Scavo con la Scuola: Gortina di Creta

    Directory of Open Access Journals (Sweden)

    Elena Belgiovine

    2014-08-01

    Full Text Available Le indagini condotte dall’Università degli Studi di Milano a partire dal 2003 sul sito di Gortina si sono concentrate nell’area a S del cosiddetto Pretorio, portando alla luce un edificio termale, le “Terme Milano”, che sono state edificate sulle rovine dello stadio ellenistico a partire dalla seconda metà del IV d.C. Il complesso mostra diverse fasi di utilizzo che si estendono fino alla seconda metà del VII d.C. quando l’edificio cade in rovina. Successivamente l’area viene sfruttata per il recupero di materiale da costruzione e parzialmente invasa da modeste abitazioni.

  14. Il controllo di gestione e operativo delle commesse per una impresa di costruzioni: nuovo impianto di trattamento e recupero di rifiuti urbani.

    Directory of Open Access Journals (Sweden)

    Matteo Camprini

    2013-10-01

    Full Text Available Il mercato delle costruzioni in Italia soffre problemi di maturità da molto tempo. Dagli anni ’90, infatti, per superare i fatti di tangentopoli venne riformata la legislazione dei lavori pubblici per giungere a livelli di competizione maggiori e più simili a quelli esistenti in Europa.  In questo contesto le imprese che per la loro struttura culturale, organizzativa e produttiva mostravano maggiore sensibilità a tali aspetti avviarono processi di formazione e riorganizzazione introducendo specifiche procedure mirate alla gestione completa dei progetti trasformandosi così da imprese di sola produzione a imprese operanti per progetti.La presente memoria vuole descrivere il sistema di gestione attuato, le modifiche ed i miglioramenti che si sono susseguiti nel tempo,  la sua struttura organizzativa e gli strumenti di lavoro messi a disposizione.A conclusione verrà illustrata l’applicazione al caso concreto della costruzione del nuovo impianto di trattamento e recupero di rifiuti urbani.

  15. Effetti di serie: semiotica della dipendenza televisiva

    Directory of Open Access Journals (Sweden)

    Valentina Pisanty

    2016-06-01

    Full Text Available Nelle conversazioni quotidiane e in rete si discute molto della dipendenza da serie televisive, con particolare riferimento alle serie continue di ultima generazione (tra cui Game of Thrones, Homeland, House of Cards e simili, le quali sembrano incoraggiare il cosiddetto binge-watching più di qualsiasi altra fiction precedente. Molti commentatori paragonano questo fenomeno alla tossicodipendenza, e una recente ricerca psicologica (Hoon Hi Sung, Eun Yeon Kang, Wei-Na Lee 2015 collega la dipendenza da serie alla depressione. Ma quanto è accurato (o invece metaforico l’accostamento della compulsione seriale alle forme più tradizionali di intossicazione? Questo articolo analizza la vasta fenomenologia delle dipendenze da serie da un prospettiva semiotica, con il proposito di distinguere tra diversi stili di fruizione immersiva: dalle maratone solitarie e onnivore che effettivamente possono suscitare sentimenti individuali di frustrazione e di inadeguatezza, all’intensa attività sociale che viceversa circonda alcuni specifici culti televisivi. Sino a che punto è possibile ascrivere una simile gamma di atteggiamenti interpretativi alle strutture stesse dei testi, per esempio in rapporto alle trame, all’architettura dei mondi narrativi e alla costruzione di personaggi con cui gli spettatori possono identificarsi? E quali effetti producono le frequenti e prolungate immersioni nei mondi seriali sulla percezione collettiva del mondo reale?

  16. Pantani di Marco Martinelli: una narrazione polifonica

    Directory of Open Access Journals (Sweden)

    Franco Nasi

    2014-05-01

    Full Text Available In questo articolo si analizza il testo drammaturgico Pantani di Marco Martinelli, una veglia epica teatrale di uno dei più noti eroi dello sport italiano degli ultimi anni. Il dramma rilegge anche la storia di Pantani e ricostruisce gli strani avvenimenti che portarono alla sospensione, alla estromissione del ciclista dal Giro d’Italia nel 1999, e in seguito alla sua profonda crisi psicologica e tragica morte in solitudine in un hotel, a soli 34 anni. Oltre alle modalità proprie della veglia rituale, il dramma utilizza anche i metodi del processo giudiziario, e offre testimonianze dettagliate che conducono a una riflessione critica sulla società italiana negli anni del potere politico di Berlusconi e della sua filosofia del consumismo. I tre diversi generi della retorica classica (epidittico, giudiziario e deliberativo si mescolano in questa complessa tessitura teatrale. Coniugando informazioni (processo e rito (veglia, Martinelli riesce a fondere la tragedia greca (forma mimetica e corale e il moderno teatro di narrazione (forma diegetica monologante. Combinando assieme scene intensamente drammatiche, ricordi di imprese sportive epiche, passaggi giocosi e parodici, e giustapponendo vari stili e registri (giornalistico, lirico, parodico, elegiaco, Martinelli crea momenti di forte “straniamento” e sorpresa, e rende particolarmente efficace il rito funebre, la ricostruzione storica della tragica vicenda di Pantani e la critica all’ideologia che ha dominato l’Italia negli anni di Berlusconi.

  17. Migrazioni di archetipi: tradizioni e rapimenti

    Directory of Open Access Journals (Sweden)

    Giulia Valsecchi

    2014-07-01

    Full Text Available Quel che resta di una trasmissione orale o scritta sono tracce multiple e mai estinte. I segni e i simboli che la rinnovano, secondo influsso e revisione dei confini di tradizione, traduzione o plagio, sono oggetto del volume collettaneo Archetypes in Literatures and Cultures – Cultural and Re- gional Studies a cura di Rahilya Geybullayeva (Baki Slavian Universiteti, Azerbaijan. Un’analisi a più voci degli attraversamenti identitari per migrazioni di archetipi nello spazio-tempo delle lettera- ture ed epopee.

  18. Fenologia dei Chirotteri nella grotta di Onferno

    Directory of Open Access Journals (Sweden)

    Massimo Bertozzi

    2003-10-01

    Full Text Available Con le sue 11 specie e le oltre 6000 presenze di Chirotteri la Riserva naturale orientata di Onferno è certamente un punto di notevole interesse nel patrimonio naturale italiano. A seguito dei piani di indagine e di sorveglianza posti in essere fin dalla sua creazione nel 1992 da parte della gestione della Riserva e soprattutto grazie al progetto LIFE in corso, si riassumono qui i principali tratti fenologci delle diverse specie nella cavità. Il sistema ipogeo è altamente differenziato topografica e in termini di microclima, come rilevato dal sistema di monitoraggio presente. Da Dicembre inizia il periodo più tipicamente invernale con rapido abbandono della cavità principale da parte dei miniotteri. Vi rimangono poche decine di esemplari e altrettanti rinolofidi delle diverse specie. Tale situazione si prolunga con alcune piccole variazioni fino a Marzo. Al cambio di stagione i miniotteri si muovono dai rifugi posti soprattutto in un tunnel a S. Marino (circa 11 km in linea d?aria a temperatura tra i 3 e 5 °C per tornare nel tratto principale a circa 7°C. I rinolofidi mantengono le posizioni e i numeri precedenti. Con Aprile il gruppo dei miniotteri, oramai completo o quasi, si sposta nella Sala Guano o rimane in vari ambiti del percorso principale. I rinolofidi appaiono in movimento ma il loro numero diminuisce almeno dalle zone di controllo. A Maggio compaiono anche i grandi vespertili già aggregati al grande gruppo dei miniotteri che spesso si presenta in contingenti suddivisi in vari ambiti della grotta. Non si ritrovano più rinolofi maggiori, mentre euryale e minore raggiungono le sale più calde e secche. Con Giugno i contingenti si concentrano nella grande sala ?Quarina? per formare nella seconda metà la colonia riproduttiva. Dal 15 circa iniziano i parti in tutte le specie. Nel Miniottero si registrano scarti di almeno una settimana tra l?avvio della riproduzione e le ultime nascite. Tutto Luglio è speso nella crescita dei

  19. Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users.

    Science.gov (United States)

    Ndombi, Eric M; Budambula, Valentine; Webale, Mark K; Musumba, Francis O; Wesongah, Jesca O; Mibei, Erick; Ahmed, Aabid A; Lihana, Raphael; Were, Tom

    2015-12-01

    Adiponectin is an important marker of anthropometric profiles of adipose tissue. However, association of adiponectin and adiposity in HIV mono- and co-infected and hepatitis (HCV) injection drug users (IDUs) has not been elucidated. Therefore, the relationship of total adiponectin levels with anthropometric indices of adiposity was examined in HIV mono-infected (anti-retroviral treatment, ART-naive, n=16 and -experienced, n=34); HCV mono-infected, n=36; HIV and HCV co-infected (ART-naive, n=5 and -experienced, n=13); uninfected, n=19 IDUs; and healthy controls, n=16 from coastal Kenya. Anthropometric indices of adiposity were recorded and total circulating adiponectin levels were measured in serum samples using enzyme-linked immunosorbent assay. Adiponectin levels differed significantly amongst the study groups (P<0.0001). Post-hoc analyses revealed decreased levels in HIV mono-infected ART-naive IDUs in comparison to uninfected IDUs (P<0.05) and healthy controls (P<0.05). However, adiponectin levels were elevated in HCV mono-infected IDUs relative to HIV mono-infected ART-naive (P<0.001) and -experienced (P<0.001) as well as HIV and HCV co-infected ART-naive (P<0.05) IDUs. Furthermore, adiponectin correlated with weight (ρ=0.687; P=0.003) and BMI (ρ=0.598; P=0.014) in HIV mono-infected ART-naive IDUs; waist circumference (ρ=-0.626; P<0.0001), hip (ρ=-0.561; P=0.001) circumference, and bust-to-waist ratio (ρ=0.561; P=0.001) in HIV mono-infected ART-experienced IDUs; waist girth (ρ=0.375; P=0.024) in HCV mono-infected IDUs; and waist-to-hip ratio (ρ=-0.872; P=0.048) in HIV and HCV co-infected ART-naive IDUs. Altogether, these results suggest suppression of adiponectin production in treatment-naive HIV mono-infected IDUs and that circulating adiponectin is a useful surrogate marker of altered adiposity in treatment-naive and -experienced HIV and HCV mono- and co-infected IDUs. © 2015 The authors.

  20. Kelimpahan Arthropoda Karnivora di Pertanaman Padi Ratun di Sawah Lebak yang Diaplikasikan Bioinsektisida Bacillus Thuringiensis

    OpenAIRE

    Sunariah, Fila; Herlinda, Siti; Windusari, Yuanita

    2016-01-01

    Kelimpahan Arthropoda karnivora di pertanaman padi ratun di sawah lebak yang diaplikasikan bioinsektisida Bacillus thuringiensis telah dilakukan di sawah lebak Pemulutan, Ogan Ilir Sumatera Selatan selama Agustus-Oktober 2013. Penelitian bertujuan untuk mengetahui kelimpahan Arthropoda karnivora padi ratun yang diberi aplikasi Bacillus thurngiensis dan tanpa diberi aplikasi bioinsektisida. Pengambilan sampel spesies Arthropoda dilakukan dengan menggunakan jaring serangga pada tajuk tanaman pa...

  1. ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation.

    Science.gov (United States)

    Feijs, Karla Lh; Kleine, Henning; Braczynski, Anne; Forst, Alexandra H; Herzog, Nicolas; Verheugd, Patricia; Linzen, Ulrike; Kremmer, Elisabeth; Lüscher, Bernhard

    2013-01-19

    Although ADP-ribosylation has been described five decades ago, only recently a distinction has been made between eukaryotic intracellular poly- and mono-ADP-ribosylating enzymes. Poly-ADP-ribosylation by ARTD1 (formerly PARP1) is best known for its role in DNA damage repair. Other polymer forming enzymes are ARTD2 (formerly PARP2), ARTD3 (formerly PARP3) and ARTD5/6 (formerly Tankyrase 1/2), the latter being involved in Wnt signaling and regulation of 3BP2. Thus several different functions of poly-ADP-ribosylation have been well described whereas intracellular mono-ADP-ribosylation is currently largely undefined. It is for example not known which proteins function as substrate for the different mono-ARTDs. This is partially due to lack of suitable reagents to study mono-ADP-ribosylation, which limits the current understanding of this post-translational modification. We have optimized a novel screening method employing protein microarrays, ProtoArrays®, applied here for the identification of substrates of ARTD10 (formerly PARP10) and ARTD8 (formerly PARP14). The results of this substrate screen were validated using in vitro ADP-ribosylation assays with recombinant proteins. Further analysis of the novel ARTD10 substrate GSK3β revealed mono-ADP-ribosylation as a regulatory mechanism of kinase activity by non-competitive inhibition in vitro. Additionally, manipulation of the ARTD10 levels in cells accordingly influenced GSK3β activity. Together these data provide the first evidence for a role of endogenous mono-ADP-ribosylation in intracellular signaling. Our findings indicate that substrates of ADP-ribosyltransferases can be identified using protein microarrays. The discovered substrates of ARTD10 and ARTD8 provide the first sets of proteins that are modified by mono-ADP-ribosyltransferases in vitro. By studying one of the ARTD10 substrates more closely, the kinase GSK3β, we identified mono-ADP-ribosylation as a negative regulator of kinase activity.

  2. Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin-Mono-Resistant Pulmonary Tuberculosis in Lima, Peru.

    Science.gov (United States)

    Villegas, Leonela; Otero, Larissa; Sterling, Timothy R; Huaman, Moises A; Van der Stuyft, Patrick; Gotuzzo, Eduardo; Seas, Carlos

    2016-01-01

    Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB) treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance on treatment outcomes. A prospective, observational cohort study enrolled adults with a first episode of smear-positive pulmonary TB from 34 health facilities in a northern district of Lima, Peru, from March 2010 through December 2011. Participants were interviewed and a sputum sample was cultured on Löwenstein-Jensen (LJ) media. Drug susceptibility testing was performed using the proportion method. Medication regimens were documented for each patient. Our primary outcomes were treatment outcome at the end of treatment. The secondary outcome included recurrent episodes among cured patients within two years after completion of the treatment. Of 1292 patients enrolled, 1039 (80%) were culture-positive. From this subpopulation, isoniazid mono-resistance was present in 85 (8%) patients and rifampicin mono-resistance was present in 24 (2%) patients. In the multivariate logistic regression model, isoniazid mono-resistance was associated with illicit drug use (adjusted odds ratio (aOR) = 2.10; 95% confidence interval (CI): 1.1-4.1), and rifampicin mono-resistance was associated with HIV infection (aOR = 9.43; 95%CI: 1.9-47.8). Isoniazid mono-resistant patients had a higher risk of poor treatment outcomes including treatment failure (2/85, 2%, p-valuemono-resistant patients had a higher risk of death (2/24, 8%, pmono-resistance was found among TB patients in our low HIV burden setting which were similar to regions with high HIV burden. Patients with isoniazid and rifampicin mono-resistance had an increased risk of poor treatment outcomes.

  3. Systemic lupus erythematosus patients contain significantly less igm against mono-methylated lysine than healthy subjects.

    Directory of Open Access Journals (Sweden)

    Sha Guo

    Full Text Available Post-translational modifications on proteins are important in biological processes but may create neo-epitopes that induce autoimmune responses. In this study, we measured the serum IgG and IgM response to a set of non-modified or acetyl- and methyl-modified peptides corresponding to residues 1-19 of the histone 3 N-terminal tail in systemic lupus erythematosus (SLE patients and healthy subjects. Our results indicated that the SLE patients and healthy subjects produced antibodies (Abs to the peptides, but the two groups had different Ab isotype and epitope preferences. Abs to the non-modified form, H31-19, were of the IgG isotype and produced by SLE patients. They could not recognize the scrambled H31-19, which contained the same amino acid composition but a different sequence as H31-19. In comparison, healthy subjects in general did not produce IgG against H31-19. However, about 70% of the healthy subjects produced IgM Abs against mono-methylated K9 of H31-19 (H31-19K9me. Our further studies revealed that ε-amine mono-methylated lysine could completely inhibit the IgM binding to H31-19K9me, but lysine had no inhibitory effect. In addition, the IgM Abs could bind peptides containing a mono-methylated lysine residue but with totally different sequences. Thus, mono-methylated lysine was the sole epitope for the IgM. Interestingly, SLE patients had much lower levels of this type of IgM. There was no obvious correlation between the IgM levels and disease activity and the decreased IgM was unlikely caused by medical treatments.We also found that the IgM Abs were not polyreactive to dsDNA, ssDNA, lipopolysaccharide (LPS or insulin and they did not exist in umbilical cord serum, implying that they were not natural Abs. The IgM Abs against mono-methylated lysine are present in healthy subjects but are significantly lower in SLE patients, suggesting a distinct origin of production and special physiological functions.

  4. Single-step brazing process for mono-block joints and mechanical testing

    International Nuclear Information System (INIS)

    Casalegno, V.; Ferraris, M.; Salvo, M.; Rizzo, S.; Merola, M.

    2007-01-01

    Full text of publication follows: Plasma facing components act as actively cooled thermal shields to sustain thermal and particle loads during normal and transient operations in ITER (International Thermonuclear Experimental Reactor). The plasma-facing layer is referred to as 'armour', which is made of either carbon fibre reinforced carbon composite (CFC) or tungsten (W). CFC is the reference design solution for the lower part of the vertical target of the ITER divertor. The armour is joined onto an actively cooled substrate, the heat sink, made of precipitation hardened copper alloy CuCrZr through a thin pure copper interlayer to decrease, by plastic deformation, the joint interface stresses; in fact, the CFC to Cu joint is affected by the CTE mismatch between the ceramic and metallic material. A new method of joining CFC to copper and CFC/Cu to CuCrZr alloy was effectively developed for the flat-type configuration; the feasibility of this process also for mono-block geometry and the development of a procedure for testing mono-block-type mock-ups is described in this work. The mono-block configuration consists of copper alloy pipe shielded by CFC blocks. It is worth noting that in mono-block configuration, the large thermal expansion mismatch between CFC and copper alloy is more significant than for flat-tile configuration, due to curved interfaces. The joining technique foresees a single-step brazing process: the brazing of the three materials (CFC-Cu-CuCrZr) can be performed in a single heat treatment using the same Cu/Ge based braze. The composite surface was modified by solid state reaction with chromium with the purpose of increasing the wettability of CFC by the brazing alloy. The CFC substrate reacts with Cr which, forming a carbide layer, allows a large reduction of the contact angle; then, the brazing of CFC to pure copper and pure copper to CuCrZr by the same treatment is feasible. This process allows to obtain good joints using a non-active brazing

  5. Qualche considerazione sulle "Pensées" di Montesquieu

    Directory of Open Access Journals (Sweden)

    Fabiana Fraulini

    2011-02-01

    Full Text Available The paper examines the the books: Montesquieu, "Pensieri diversi", a cura di D. Felice, Napoli, Liguori, 2010; Montesquieu, "Riflessioni e pensieri inediti (1716-1755", tr. it. di L. Ginzburg, intr. di D. Felice, Bologna, CLUEB, 2010.

  6. Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI

    International Nuclear Information System (INIS)

    Winfield, Jessica M.; Collins, David J.; Morgan, Veronica A.; DeSouza, Nandita M.; Orton, Matthew R.; Ind, Thomas E.J.; Attygalle, Ayoma; Hazell, Steve

    2017-01-01

    Assessment of empirical diffusion-weighted MRI (DW-MRI) models in cervical tumours to investigate whether fitted parameters distinguish between types and grades of tumours. Forty-two patients (24 squamous cell carcinomas, 14 well/moderately differentiated, 10 poorly differentiated; 15 adenocarcinomas, 13 well/moderately differentiated, two poorly differentiated; three rare types) were imaged at 3 T using nine b-values (0 to 800 s mm -2 ). Mono-exponential, stretched exponential, kurtosis, statistical, and bi-exponential models were fitted. Model preference was assessed using Bayesian Information Criterion analysis. Differences in fitted parameters between tumour types/grades and correlation between fitted parameters were assessed using two-way analysis of variance and Pearson's linear correlation coefficient, respectively. Non-mono-exponential models were preferred by 83 % of tumours with bi-exponential and stretched exponential models preferred by the largest numbers of tumours. Apparent diffusion coefficient (ADC) and diffusion coefficients from non-mono-exponential models were significantly lower in poorly differentiated tumours than well/moderately differentiated tumours. α (stretched exponential), K (kurtosis), f and D* (bi-exponential) were significantly different between tumour types. Strong correlation was observed between ADC and diffusion coefficients from other models. Non-mono-exponential models were preferred to the mono-exponential model in DW-MRI data from cervical tumours. Parameters of non-mono-exponential models showed significant differences between types and grades of tumours. (orig.)

  7. Conversion of methane to methanol with a bent mono(μ-oxo)dinickel anchored on the internal surfaces of micropores.

    Science.gov (United States)

    Shan, Junjun; Huang, Weixin; Nguyen, Luan; Yu, Ying; Zhang, Shiran; Li, Yuanyuan; Frenkel, Anatoly I; Tao, Franklin Feng

    2014-07-22

    The oxidation of methane to methanol is a pathway to utilizing this relatively abundant, inexpensive energy resource. Here we report a new catalyst, bent mono(μ-oxo)dinickel anchored on an internal surface of micropores,which is active for direct oxidation. It is synthesized from the direct loading of a nickel precursor to the internal surface of micropores of ZSM5 following activation in O2. Ni 2p3/2 of this bent mono(μ-oxo)dinickel species formed on the internal surface of ZSM5 exhibits a unique photoemission feature, which distinguishes the mono(μ-oxo)dinickel from NiO nanoparticles. The formation of the mono(μ-oxo)dinickel species was confirmed with X-ray absorption near-edge structure (XANES) and extended X-ray absorption fine structure (EXAFS). This mono(μ-oxo)dinickel species is active for the direct oxidation of methane to methanol under the mild condition of a temperature as low as 150 °C in CH4 at 1 bar. In-situ studies using UV-vis, XANES, and EXAFS suggest that this bent mono(μ-oxo)dinickel species is the active site for the direct oxidation of methane to methanol. The energy barrier of this direct oxidation of methane is 83.2 kJ/mol.

  8. Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI

    Energy Technology Data Exchange (ETDEWEB)

    Winfield, Jessica M.; Collins, David J.; Morgan, Veronica A.; DeSouza, Nandita M. [The Royal Marsden NHS Foundation Trust, MRI Unit, Sutton, Surrey (United Kingdom); The Institute of Cancer Research, Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, London (United Kingdom); Orton, Matthew R. [The Institute of Cancer Research, Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, London (United Kingdom); Ind, Thomas E.J. [The Royal Marsden NHS Foundation Trust, Gynaecology Unit, London (United Kingdom); Attygalle, Ayoma; Hazell, Steve [The Royal Marsden NHS Foundation Trust, Department of Histopathology, London (United Kingdom)

    2017-02-15

    Assessment of empirical diffusion-weighted MRI (DW-MRI) models in cervical tumours to investigate whether fitted parameters distinguish between types and grades of tumours. Forty-two patients (24 squamous cell carcinomas, 14 well/moderately differentiated, 10 poorly differentiated; 15 adenocarcinomas, 13 well/moderately differentiated, two poorly differentiated; three rare types) were imaged at 3 T using nine b-values (0 to 800 s mm{sup -2}). Mono-exponential, stretched exponential, kurtosis, statistical, and bi-exponential models were fitted. Model preference was assessed using Bayesian Information Criterion analysis. Differences in fitted parameters between tumour types/grades and correlation between fitted parameters were assessed using two-way analysis of variance and Pearson's linear correlation coefficient, respectively. Non-mono-exponential models were preferred by 83 % of tumours with bi-exponential and stretched exponential models preferred by the largest numbers of tumours. Apparent diffusion coefficient (ADC) and diffusion coefficients from non-mono-exponential models were significantly lower in poorly differentiated tumours than well/moderately differentiated tumours. α (stretched exponential), K (kurtosis), f and D* (bi-exponential) were significantly different between tumour types. Strong correlation was observed between ADC and diffusion coefficients from other models. Non-mono-exponential models were preferred to the mono-exponential model in DW-MRI data from cervical tumours. Parameters of non-mono-exponential models showed significant differences between types and grades of tumours. (orig.)

  9. Pianificazione urbana e comportamenti di viaggio: più di una relazione

    Directory of Open Access Journals (Sweden)

    Elisabetta Vitale Brovarone

    2010-04-01

    Full Text Available L’influenza dei caratteri urbani sulla domanda di mobilità è un tema ampiamente dibattuto e studiato. Al di là delle assunzioni teoriche a riguardo, molti studiosi hanno tentato di individuare empiricamente nessi attestanti questo fenomeno. Gran parte della letteratura scientifica sul tema può essere ricondotta al dibattito sulla città compatta e sullo sprawl. Due principali obiettivi contraddistinguono questo dibattito: la comprensione delle complesse dinamiche che legano la domanda di mobilità ai caratteri urbani e l’individuazione di configurazioni sostenibili degli usi del suolo. Il fenomeno è dunque studiato al fine dello sviluppo di strategie fondate sull’integrazione tra i trasporti e gli usi del suolo, finalizzate a limitare l’uso dell’auto e ad ottenere una distribuzione modale degli spostamenti più equilibrata. Buona parte della ricerca scientifica, specialmente nell’ultimo decennio, è dunque focalizzata sull’identificazione di nessi causali tra gli usi del suolo e i trasporti, per supportare, o in alcuni casi mettere in discussione, esperienze e politiche integrate. Nonostante la quantità e varietà di studi dedicati al tema, il fenomeno è ancora lungi dall’essere compreso e dimostrato empiricamente. Il dibattito in proposito è ampio e l’impressione è che con l’aumentare degli studi in proposito e del livello di approfondimento delle analisi diminuisca la sensazione di chiarezza. Attraverso un’analisi della letteratura, l’articolo mette in evidenza i principali problemi emergenti dal dibattito. Senza negare l’importanza del riconoscimento di nessi causali tra i caratteri degli insediamenti e la domanda di mobilità, opinione di chi scrive è che l’individuazione di questi nessi non debba necessariamente costituire una condizione imprescindibile per la definizione e l’adozione di un approccio integrato.

  10. Giovani migranti si raccontano: una ricerca all’interno di un Centro di Aggregazione Giovanile

    Directory of Open Access Journals (Sweden)

    Caterina Rizzo

    2012-04-01

    Full Text Available Analizzare i destini delle cosiddette seconde generazioni costituisce un punto centrale per comprendere le caratteristiche della società odierna, in primo luogo perché il grado di integrazione dei giovani figli della migrazione costituisce la cartina tornasole dei più ampi processi di inclusione messi in atto dalla società, e in secondo luogo per la centralità che le traiettorie di vita di questi giovani rivestono all'interno dei processi di socializzazione delle nuove generazioni nel loro complesso. In un'epoca caratterizzata da un eccezionale pluralismo culturale come quella in cui viviamo è evidente come i due ambienti tradizionalmente deputati ai processi di socializzazione, quali la famiglia e la scuola, vengano affiancati da molte altre istanze: basti pensare ai luoghi educativi extra-scolastici, alle associazioni di vario tipo, ai vecchi e nuovi media, ma anche al gruppo dei pari, agli adulti di riferimento e a tutta quella pluralità di legami, relazioni e appartenenze che nell'odierna società globale è possibile intrecciare. All'interno di un frame sociale così multiforme cosa avviene dunque nelle già complesse biografie dei giovani migranti? E quali sono le narrazioni che ne svelano il senso? Come vengono gestite le eventuali contraddizioni tra messaggi provenienti dai differenti ambienti culturali? E infine, quali elementi rendono peculiari le storie di vita, i progetti, le percezioni del Sé e i processi di socializzazione di questo gruppo sociale? Sono queste le principali questioni approfondite nella ricerca qui presentata: una ricerca condotta nel 2009 che ha individuato come campo d'indagine un Centro di Aggregazione Giovanile della città di Bergamo.

  11. Linguistica antica e linguistica di oggi

    Directory of Open Access Journals (Sweden)

    Gualtiero Calboli

    2010-11-01

    Full Text Available La linguistica moderna si fonda sulla linguistica antica, in particolare sulla grammatica dei Greci e dei Latini: ad es. il concetto di frase come valore di verità (come la combinazione di parti del discorso sufficiente ad esprimere un giudizio di vero o di falso, che costituisca poi il punto di riferimento di tutti i componenti del discorso (Chomsky e Montagne, è già di Aristotele e poi degli Stoici che hanno sviluppato la dottrina dell’axioma. Partendo, poi, dal criterio della ‘grammaticalizzazione’, largamente usato nella linguistica odierna in una prospettiva di storia della lingua, si affronta il concetto di lingua L o ‘lingua logica’ come attenzione metalinguistica e applicazione della linguistica derivata dal valore di verità (Montagne e Creswell. Si è messo, quindi, in rapporto questo atteggiamento con la tradizione legislativa e giudiziaria mesopotamica, semitica, indo-europea (Ittiti, Greci e Latini. In questo ambito si mostra come da una parte abbia cominciato a formarsi una coscienza linguistica e metalinguistica, e, d’altra parte, come la stessa lingua si sia arricchita di forme più complesse quali congiuntivo e ottativo e altre forme ‘oblique’ nominali e verbali (Vedico, Greco, Latino, Tocario. Lo sviluppo delle lingue indeuropee ha comportato, poi, in alcune lingue un riequilibrio tra forme nominali, pronominali e verbali in stretto rapporto con la struttura della lingua (nascita dell’articolo in Greco e nelle lingue Romanze derivate dal Latino e forte riduzione o scomparsa delle forme nominali del verbo come costruzioni participiali e infinitive (AcI. Si connette, così, il problema dei cambiamenti che sono entrati stabilmente nella lingua come effetto della loro entrata nella ‘core grammar’ della lingua e, quindi, si affronta il problema di come individuare la ‘core grammar’ di una lingua: in Latino individuazione della ‘core grammar’ tramite il bilinguismo (Greco–Latino. In conclusione e in

  12. Reformasi di Kementerian Pertahanan RI

    Directory of Open Access Journals (Sweden)

    Beni Sukadis

    2016-11-01

    Full Text Available Abstrak Reformasi bidang pertahanan yang dialami Indonesia sejak disahkan UU Pertahanan Negara dan UU TNI hingga kini belum selesai karena beberapa faktor yang cukup menghambat reformasi ini. Beberapa faktor yang menghambat, yaitu masih ada budaya paternalistik dalam birokrasi, masih ada ketidakjelasan kedudukan antara menteri pertahanan dan panglima TNI dalam pembagian wewenang khususnya terkait hubungan sipil-militer dan kepemimpinan sipil yang lemah dalam mengelola reformasi di Kementerian Pertahanan. Hingga saat ini implementasi supremasi sipil masih samar di Kementerian Pertahanan, walaupun secara faktual menteri pertahanan berasal dari sipil, tapi di sisi lain dominasi militer dalam jabatan pengambilan keputusan masih terjadi. Padahal supremasi sipil seharusnya direpresentasikan dalam wujud nyata bukan hanya dari hanya dari satu posisi pimpinan, yakni bagaimana otoritas sipil secara dominan dapat mengambil keputusan politik yang otonom sesuai dengan kebijakan negara yang dimandatkan oleh UU dan aturan yang ada. Kata kunci: reformasi pertahanan, hubungan sipil militer, supremasi sipil.   Defense reform still underway since Indonesia passed the Law on State Defense and the TNI the reform law has not completed yet, because there are many factors that impede the reform process. Some of the factors are the paternalistic culture still exist in the bureaucracy, there is also ambiguity on the relations between the Defense Minister and the Commander of TNI in the division of labor especially to civil-military relations and weak civilian leadership in managing the reform at the Ministry of Defense. Until now, the implementation of civil supremacy within the Ministry is vague, although the ministers are civilian, but in fact the military domination in decision making process remains strong. Whereas, civil supremacy should not be exemplified on the top position, but the civilians authority take the lead in the decision making in accordance to the

  13. EFISIENSI PERBANKAN SYARIAH DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Afif Amirillah

    2014-09-01

    Full Text Available This research aims to find out the factors that can cause the efficiency value difference of Islamic Banking in In-donesia. The data at this research is monetary data of Islamic Banking. It was obtained from Bank of Indonesia. Then, it was divided into input and output variables. The determination of input output variables at this research uses Value Added Approach. Its input output variables consist of Demand Deposits, Saving Deposits, Time Depo-sits, Paid -In Capital, Placement at Bank ofIndonesia, Inter Bank Assets, Mudharabah, Musyara kah, Murabahah, Istishna, Ijarahand Qardh. This research used Data Envelopment Analysis method. This method has a strength that is having the capability to measure inefficiency input output variables, so that, the variable can have the efficiency. This research has resulted Islamic Banking efficiency in Indonesia, but it does not include BPRS. The mean efficiency of Islamic banking in Indonesia is 99,94%. Penelitian ini bertujuan mencari faktor –faktor penyebab perbedaan nilai efisiensiperbankan syariah di Indo-nesia yang dibandingkan secara relatif untuk setiap periode. Data yang digunakan pada penelitian ini menggu-nakan data keuangan perbankan syariah yang diperoleh dari Bank Indonesia kemudian dibagi menjadi variabel input dan output. Penentuan variabel input dan output pada penelitian ini menggunakan pendekatan Value Added Approach. Variabel input outputnyaterdiri dari : Giro iB, Tabungan iB, Deposito iB, Modal disetor, Pen-empatan padaBank Indonesia, Penempatan pada bank lain, Mudharabah, Musyarakah, Murabahah,Istishna, Ijarah dan Qardh. Pada penelitian ini menggunakan metode Data Envelopment Analysis yang mempunyai kel-ebihan dalam menghitung efisiensi untuk setiap variabel input outputyang mengalami inefisiensi. Penelitian ini menghasilkan nilai efisiensi perbankan syariah di Indoenesia (tidak termasuk BPRS. Efisiensi perbankan syariah di Indonesia mengalami efisiensi rata-rata sebesar 99,94%.

  14. LE OSSIDIANE DI PALMAROLA I MARKER DI PROVENIENZA

    Directory of Open Access Journals (Sweden)

    Andrea Macchia

    2012-04-01

    Full Text Available

    Le tracce di ossidiane e la caratterizzazione delle componenti chimiche presenti nei luoghi oggetto di indagini archeologiche, permettono l'individuazione delle antiche rotte commerciali. In Italia le aree individuate sono Monte Arci in Sardegna, Lipari e Pantelleria in Sicilia e Palmarola nel Lazio.

     

    Obsidian  from  Palmarola:  source  markers

    A  chemical  characterization  of  the  main  components  and  traces  of  obsidian  allows identifi cation  of  commercial  routes  in  antiquity.  Obsidian  sources in Prehistoric Italy were mainly four: Monte Arci in Sardinia, the islands of Lipari and Pantelleria in Sicily and the island of Palmarola in Lazio. A survey methodology on samples of obsidian from several Neolithic sites in Lazio has been developed, comparing three different analytical techniques: SEM-EDS, XRF and LA-ICP-MS, in order to obtain a wider range of data to be compared with literature records and processed by Principal Component Analysis (PCA, to defi ne relationships between samples and to assign each finding its origin.

  15. Nuovi territori di 'ndrangheta. Il caso di Reggio Emi

    Directory of Open Access Journals (Sweden)

    Federica Cabras

    2018-03-01

    Full Text Available La ‘ndrangheta a Reggio Emilia rappresenta un fenomeno trentennale. Il presente articolo si propone di analizzare le tappe fondamentali della sua storia nella provincia emiliana, le sue caratteristiche strutturali e il graduale processo di integrazione socio-economica del clan sul territorio. Chiama in causa anche il sistema cooperativo emiliano, il quale – seppur mai coinvolto nelle inchieste della magistratura -  costituisce tradizionalmente il principale operatore economico in quei settori chiave dell’imprenditoria mafiosa.  Parole chiave: mafia, ‘ndrangheta, economia, Reggio Emilia, imprese cooperative   ‘Ndrangheta is a 30-year phenomenon in Reggio Emilia. This article aims to inquire   the fundamental steps of its development, identifying the structural features of the organization and analysing its spread within the socio-economic context. Moreover, this essay focuses on the role of cooperative ventures in the key sectors of mafia’s investments. The main findings put into light many links between mafia enterprises and Emilian cooperative system. Keywords: mafia, ‘ndrangheta, economy, Reggio Emilia, cooperative venture

  16. Perkembangan penelitian di bidang pengungkapan di Indonesia: Telaah konseptual

    Directory of Open Access Journals (Sweden)

    Aqlima Cendera Dewi

    2018-03-01

    Full Text Available Abstract This study aims to provide an overview of the development of corporate information disclosure research in Indonesia taken from 11 accredited journals in Indonesia. Samples are obtained from 2004 to 2017 and obtained 66 articles covering the practice of corporate information disclosure. This research classifies articles based on topics, research methods and models used by researchers. The widest researched topics of corporate information disclosure practices are the antecedent topics of firm size and financial ratios, while the widest used research methods are analytical methods. In addition, the corporate social responsibility-based disclosure is widely studied since this disclosure was probably considered as concern of many parties, especially the general public, and causing conflict in the community. Abstrak Penelitian ini bertujuan untuk memberikan gambaran perkembangan penelitian pengungkapan informasi perusahaan di Indonesia yang diambil dari 11 jurnal terakreditasi di Indonesia. Sampel diperoleh dari tahun 2004 sampai dengan 2017 dan diperoleh sebanyak 66 artikel yang membahas mengenai praktik pengungkapan informasi perusahaan. penelitian ini mengklasifikasikan artikel berdasarkan topik, metode penelitian dan model yang digunakan oleh peneliti. Topik yang paling banyak diteliti dari praktik pengungkapan informasi perusahaan adalah topik anteseden yaitu ukuran perusahaan dan rasio keuangan, sedangkan metode penelitian yang paling banyak digunakan adalah metode analitik. Sementara pengungkapan berbasis corporate social responsibility adalah yang paling banyak diteliti karena kemungkinan dianggap menyangkut banyak pihak terutama masyarakat umum dan banyak menimbulkan konflik ditengah masyarakat.

  17. LIM e pratiche di insegnamento: quali sfide per la valutazione?

    Directory of Open Access Journals (Sweden)

    Simonetta Leonardi

    2013-03-01

    Full Text Available Il contributo affronta il tema del rapporto tra le pratiche di uso della LIM e i metodi di valutazione. Partendo dalla presentazione di una specifica esperienza e sottolineando il legame con il tema della motivazione, si presentano modalità di uso della LIM che portano alla percezione di interventi efficaci da parte del docente. In tal senso un approccio di natura empirica può costituire il primo passo verso la valutazione dell’uso della LIM.

  18. Influenza delle politiche pubbliche sulle strategie logistiche di impresa

    OpenAIRE

    Claudia Burlando; Manuela Basta

    2004-01-01

    Lo sviluppo delle attività di trasporto, distribuzione e logistica avuto in Europa nel corso degli ultimi venti anni risulta strettamente connesso con lo sviluppo economico ed industriale e, in un secondo momento, con i processi di globalizzazione. Si amplia quindi il campo di riferimento della logistica che esce dai singoli confini nazionali e necessita di nuovi modelli gestionali e di livelli di efficienza organizzativa crescenti al crescere degli ambiti territoriali in cui si deve muovere ...

  19. EKONOMI PEKARANGAN DI PEDESAAN JAWA

    Directory of Open Access Journals (Sweden)

    Dede Mulyanto

    2013-04-01

    Full Text Available Tujuan artikel ini adalah untuk menganalisa peran pekarangan sebagai sumber ketersediaan pangan, energi rumahtangga, dan uang tunai bagi rumahtangga petani. Bagi orang Jawa lahan tidak hanya tempat bekerja mereka tetapi sebagai sebuah status sosial, ekoncomi dan politik di masyarakat. Disinilah pekarangan, sebuah lahan kecil di rumah, mengambil peran ketika petani menghadapai kesulitan ekonomi yang dikarenakan lahan garapannya tidak menguntungkan. Rumusan masalahnya adalah bagaimana karakteristik desa Wetankali dan bagaimana bentuk pemanfaatan ekonomi pekarangan yang terjadi di sana. Metode penelitian yang digunakan adalah etnografis disertai survei dengan kuisioner dan analisis data sekunder. Penelitian ini dilakukan di Desa Wetankali Kecamatan Kutocilik Kabupaten Banyumas. Pekarangan bagi masyarakat Jawa merupakan benteng yang dengannya mereka dapat bertahan hidup. Pekarangan ditanami beberapa jenis tanaman ynag dapat dijual untuk menambah pendapatan rumahtangga petani. Bersaamaan dengan pertumbuhan penduduk yang naik, pekarangan berubah bentuk menjadi semakin sempit karena masyarakat lebih memilih menggunakan lahannya untuk hunian. Akibatnya, untuk rumahtangga miskin, sumber makanan pendukung dan energi murah mulai menghilang. The objective of this article is to analyse the role played by house yards or home garden as source of food storage, household energy, and cash for peasant household. For Javanese peasant, yard was not only a  place for work, but also a space to represent economy and social status. The importance of house yards is felt in difficult situation such as economic crises and corpse failure. Research questions in this anysisis are how about the characteristics of Wetankali village and how about the pattern of using home garden or home yard there. Research method used is etnography with survey using questionaire and secondary data analysis. The research was conducted in Watankali, Kutocilik Banyumas. For Javanese, yards

  20. Presentation of the volume “Scritti africani”, by Antonino di Vita

    Directory of Open Access Journals (Sweden)

    Attilio Mastino

    2016-12-01

    Full Text Available Presentation of the book Antonio Di Vita, Scritti africani, a cura di Maria Antonietta Rizzo Di Vita e Ginette Di Vita Evrard, Collana Monografie di Archeologia libica XXXVIII 2015, L’Erma di Bretschneider, Roma. Roma, 6 ottobre 2016 – Istituto Nazionale di Studi Romani, Piazza Cavalieri di Malta, 2