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Sample records for alicyclic mono di

  1. Synthesis of Mono-and Di-fluorinated Benzimidazoles

    Institute of Scientific and Technical Information of China (English)

    Liang Wu; Liu Gang

    2011-01-01

    Three efficient methods to synthesize mono-and di-fluofinated benzimidazoles are reported. These methods provide 5-amino-6-fluoro-benzimidazoles (5), 5,7-difluoro-benzimidazoles (10), and 6-fluoro-benzimidazoles (13) starting from commercially available 1,5-difluoro-2,4-dinitrobenzene (DFDNB), 2,3,4,5-tetrafluoro-6-nitrobenzoic acid (TFNBA), and 2,4-difluoro-l-aitrobenzene (DFNB), respectively.

  2. Mono- and di-cationic hydrido boron compounds.

    Science.gov (United States)

    Ghadwal, Rajendra S; Schürmann, Christian J; Andrada, Diego M; Frenking, Gernot

    2015-08-28

    Brønsted acid HNTf2 (Tf = SO2CF3) mediated dehydrogenative hydride abstraction from (L(1))BH3 () and (L(2))BH3 () (L(1) = IPrCH2 = 1,3-(2,6-di-isopropylphenyl)imidazol-2-methylidene (); L(2) = SIPrCH2 = 1,3-(2,6-di-isopropylphenyl)imidazolidin-2-methylidiene ()) affords thermally stable hydride bridged mono-cationic hydrido boron compounds [{(L(1))BH2}2(μ-H)](NTf2) () and [{(L(2))BH2}2(μ-H)](NTf2) (). Furthermore, hydride abstraction yields di-cationic hydrido boron compounds [{(L(1))BH}2(μ-H)2](NTf2)2 () and [{(L(2))BH}2(μ-H)2](NTf2)2 (). Unique cationic boron compounds with CH2BH2(μ-H)BH2CH2 ( and ) and CH2BH(μ-H)2BHCH2 ( and ) moieties feature a 3c-2e bond and have been fully characterized. Interesting electronic and structural features of compounds are analysed using spectroscopic, crystallographic, and computational methods. PMID:26200103

  3. DECHLORINATION ACTIVITY (CROSS-ACCLIMATION) OF FRESHWATER SEDIMENTS ADAPTED TO MONO- AND DI-CHLOROPHENOLS

    Science.gov (United States)

    The reductive dechlorination of chlorophenols (CPs) in sediment slurries (10% solids) adapted to dechlorinate mono- and di-CPs (DCP) was investigated to define the regiospecificity of the dechlorination reaction. nadapted sediment slurries amended with various ortho-substituted C...

  4. Chromatographic separation and characterization of mono-, di- and triaromatic hydrocarbons in gas oil

    Energy Technology Data Exchange (ETDEWEB)

    Rashid, H.A.; Fakhri, N.A.; Dekran, S.B.; Abdulla, N.I.

    1989-04-01

    A simple procedure is described for separation of aromatic hydrocarbons into mono-, di- and trinuclear types in Iraqi gas oil. This is accomplished by elution through an alumina adsorption column under standardized conditions. Characterization is performed by UV-absorption and ratio matching method. The method can be used also for investigating aromatic hydrocarbon structures of other petroleum fractions.

  5. Strength and nature of hydrogen bonding interactions in mono- and di-hydrated formamide complexes.

    Science.gov (United States)

    Angelina, Emilio L; Peruchena, Nélida M

    2011-05-12

    In this work, mono- and di-hydrated complexes of the formamide were studied. The calculations were performed at the MP2/6-311++G(d,p) level of approximation. The atoms in molecules theory (AIM), based on the topological properties of the electronic density distribution, was used to characterize the different types of bonds. The analysis of the hydrogen bonds (H-bonds) in the most stable mono- and di-hydrated formamide complexes shows a mutual reinforcement of the interactions, and some of these complexes can be considered as "bifunctional hydrogen bonding hydration complexes". In addition, we analyzed how the strength and the nature of the interactions, in mono-hydrated complexes, are modified by the presence of a second water molecule in di-hydrated formamide complexes. Structural changes, cooperativity, and electron density redistributions demonstrate that the H-bonds are stronger in the di-hydrated complexes than in the corresponding mono-hydrated complexes, wherein the σ- and π-electron delocalization were found. To explain the nature of such interactions, we carried out the atoms in molecules theory in conjunction with reduced variational space self-consistent field (RVS) decomposition analysis. On the basis of the local Virial theorem, the characteristics of the local electron energy density components at the bond critical points (BCPs) (the 1/4∇ (2)ρ(b) component of electron energy density and the kinetic energy density) were analyzed. These parameters were used in conjunction with the electron density and the Laplacian of the electron density to analyze the characteristics of the interactions. The analysis of the interaction energy components for the systems considered indicates that the strengthening of the hydrogen bonds is manifested by an increased contribution of the electrostatic energy component represented by the kinetic energy density at the BCP. PMID:21506592

  6. Mixtures of mono-, di- and tri-glycerides as energy supplements to broilers’ diets

    OpenAIRE

    Sara Minieri; Clara Sargentini; Francesco Petacchi,; Mauro Antongiovanni; Arianna Buccioni

    2010-01-01

    Mixtures of mono-, di- and tri-glycerides from olive oil (MDT) were added to: palm oil (PO), olive oil (OO), soybean oil (SO), free fatty acids from palm oil (PFA), free fatty acids from olive oil (OFA). The compound mixtures were used as energy supplements in the diets of broiler chickens in comparison with plain SO and plain animal fat (AF). Two hundred and ten birds were randomly allotted to 7 dietary treatments with the diverse oil sources: 6 birds per cage, 5 cages per treatment. The eff...

  7. Electron impact single ionization of mono- and di-positive ions

    Indian Academy of Sciences (India)

    M Alfaz Uddin; A K F Haque; M S Mahbub; K R Karim; A K Basak

    2006-06-01

    The electron impact ionization cross-sections of mono- and di-positive ionic targets are calculated using a second version of the modified binary-encounter-dipole (MBED) model, previously reported [M A Uddin et al, J. Phys. B37, 1909 (2004)]. The present version differs from the previous one in the scale factor of the Burgess denominator and is applicable to targets with charges = 1 and 2. The MBED in the present form is found to work well for 11 ionic targets ranging from Be+ to K+ and complements its previous version valid for targets with > 2.

  8. Separation of mono- and di-PEGylate of exenatide and resolution of positional isomers of mono-PEGylates by preparative ion exchange chromatography.

    Science.gov (United States)

    Nguyen, Ngoc-Thanh Thi; Lee, Jae Sun; Yun, Soi; Lee, E K

    2016-07-29

    Exenatide is a synthetic version of the 39-mer peptide of Exendin-4, which is an FDA-approved therapeutic against Type II diabetes mellitus. However, exenatide has a very short in-serum half-life and PEGylation have been performed to improve its in-serum stability. PEGylation often yields multivalent binding to non-specific residues, and the desired species should be carefully separated by chromatographies. In this study, we first devised an aqueous-phase, two-step PEGylation process. This consists of thiolation of Lys 12 and 27 residues followed by attachment of PEG-maleimide (10kD) to thiol groups. This process yields various species: mono-PEGylates with positional isomers, di-PEGylate, and other higher MW substances. A prep-grade cationic exchange chromatography (HiTrap SP) at pH 3.0 partially separated mono- and di-PEGylates based on the molar ratio of conjugated PEG and peptide and thus molecular weight of the conjugates. To further investigate the chromatographic separation of positional isomers of mono-PEGylates, we prepared two kinds of exenatide analogs by point mutation; K12C and K27C. Each analog was mono-PEGylated with very high yield (>95%). When a mixture of the two positional isomers of mono-PEGylates was applied to HiTrap SP chromatography, K12C-PEGylate and K27C-PEGylate eluted separately at 0.22M and 0.33M NaCl, respectively. When the proportions of acid and its conjugate base of the amino acid residues adjacent to the PEGylation site at pH 3.0 were analyzed, K27C-PEGylate shows stronger positive charge than K12C-PEGylate, and we propose the residence time difference between the two mono-PEGylates could be due to the charge difference. ELISA result shows that the immuno-binding activity of both analogs and their mono-PEGylates are well maintained. Furthermore, both mono-PEGylates of the analogs show higher than 50-fold improved anti-trypsin stability. We expect that mono-PEGylates of the exenatide analogs are alternatives to the conventional C40

  9. Gas chromatography determination of fatty acid alkyl esters (methyl and ethyl in the presence of mono., di- and triglycerides

    Directory of Open Access Journals (Sweden)

    Paulo César Narváez Rincón

    2010-04-01

    Full Text Available Determining fatty acid methyl or ethyl esters, in the presence of mono-, di- and tri glycerides, is very important when studying fatty compounds' methanolysis or ethanolysis, as well as for controlling the quality of petrochemical products. This work presents a useful technique for determining fatty acids methyl or ethyl esters by high temperature gas chromastography in the presence of mono-, di- and triglycerides. Samples were silylated with N, O-bis (trimethylsilyl trifluroacetamide (BSTFA and then passed throught a 12m HT5 column coated with a phenyl-polysiloxane-carborane film. Standard methyl and ethyl palmitate, methyl and ethyl oleate, DL-palmitin, dipalmitin, tripalmitin and triolein solutions were used for calibrating the technique, using tricaprin as internal standard. Retention times and response factors were also determined. The results were employed in following-up palm oil methanolysis and ethanolysis reactions.

  10. Thyroid Disruption by Di-n-Butyl Phthalate (DBP) and Mono-n-Butyl Phthalate (MBP) in Xenopus laevis

    OpenAIRE

    Shen, Ouxi; Wu, Wei; Du, Guizhen; Liu, Renping; Yu, Lugang; Sun, Hong; Han, Xiumei; Jiang, Yi; Shi, Wei; Hu, Wei; Song, Ling; Xia, Yankai; Wang, Shoulin; Wang, Xinru

    2011-01-01

    Background Di-n-butyl phthalate (DBP), a chemical widely used in many consumer products, is estrogenic and capable of producing seriously reproductive and developmental effects in laboratory animals. However, recent in vitro studies have shown that DBP and mono-n-butyl phthalate (MBP), the major metabolite of DBP, possessed thyroid hormone receptor (TR) antagonist activity. It is therefore important to consider DBP and MBP that may interfere with thyroid hormone system. Methodology/Principal ...

  11. Mono-, di- and trinuclear dioxo complexes of uranium containing hydrazonato and azomethine ligands

    International Nuclear Information System (INIS)

    Mono-, di or trinuclear dioxouranium complexes with benzoylhydrazonato or azomethine ligands were prepared by reactions of common dioxouranium precursors such as UO2(NO3)2 . 6 H2O or [NBu4]2[UO2Cl4] with vanillin benzoylhydrazone (H2L4), salicylaldehyde benzoylhydrazone (H2L5), 2-hydroxyacetylbenzene salicylhydrazone (H3L6) or N-(2-ethoxycarbonyl-3-oxo-but-1-en(1)yl)-2-aminophenol (H2L7). Spectroscopic and X-ray crystallographic studies on the complexes [NBu4]2[UO2Cl4] . 2 H2L4, [UO2(HL5)(H2L5)2](NO3), [HNEt3]2[{UO2(L6)}2] and [HNEt3]2[{UO2(L7} 3O)] confirm that the individual donor atom constellation, the size of the potential chelate rings and the acidity of the OH and NH functionalities of the proligands have a strong influence on the structure of the products. (Abstract Copyright [2004], Wiley Periodicals, Inc.)

  12. Mixtures of mono-, di- and tri-glycerides as energy supplements to broilers’ diets

    Directory of Open Access Journals (Sweden)

    Sara Minieri

    2010-01-01

    Full Text Available Mixtures of mono-, di- and tri-glycerides from olive oil (MDT were added to: palm oil (PO, olive oil (OO, soybean oil (SO, free fatty acids from palm oil (PFA, free fatty acids from olive oil (OFA. The compound mixtures were used as energy supplements in the diets of broiler chickens in comparison with plain SO and plain animal fat (AF. Two hundred and ten birds were randomly allotted to 7 dietary treatments with the diverse oil sources: 6 birds per cage, 5 cages per treatment. The effects of the treatments on growth rates, feed/gain ratios and acidic composition of abdominal fat of hybrid Ross 308 female chickens were studied. The animals were slaughtered at the end of the trial, at day 35. The breast meat quality was then evaluated by a panel of 15 trained members and analysed for shelf life duration. The AF treat- ment gave the highest weight gain, but only in the first week. MDT + OO (50/50 resulted the best combination, with slight, non significant, better performances and a decidedly better quality in terms of acidic composition of abdominal fat, taste and juiciness of breast meat and shelf life.

  13. Effect of Mono and Di-rhamnolipids on Biofilms Pre-formed by Bacillus subtilis BBK006.

    Science.gov (United States)

    De Rienzo, Mayri A Díaz; Martin, Peter J

    2016-08-01

    Different microbial inhibition strategies based on the planktonic bacterial physiology have been known to have limited efficacy on the growth of biofilms communities. This problem can be exacerbated by the emergence of increasingly resistant clinical strains. Biosurfactants have merited renewed interest in both clinical and hygienic sectors due to their potential to disperse microbial biofilms. In this work, we explore the aspects of Bacillus subtilis BBK006 biofilms and examine the contribution of biologically derived surface-active agents (rhamnolipids) to the disruption or inhibition of microbial biofilms produced by Bacillus subtilis BBK006. The ability of mono-rhamnolipids (Rha-C10-C10) produced by Pseudomonas aeruginosa ATCC 9027 and the di-rhamnolipids (Rha-Rha-C14-C14) produced by Burkholderia thailandensis E264, and phosphate-buffered saline to disrupt biofilm of Bacillus subtilis BBK006 was evaluated. The biofilm produced by Bacillus subtilis BBK006 was more sensitive to the di-rhamnolipids (0.4 g/L) produced by Burkholderia thailandensis than the mono-rhamnolipids (0.4 g/L) produced by Pseudomonas aeruginosa ATCC 9027. Rhamnolipids are biologically produced compounds safe for human use. This makes them ideal candidates for use in new generations of bacterial dispersal agents and useful for use as adjuvants for existing microbial suppression or eradication strategies. PMID:27113589

  14. Isomeric mono-, di-, and tri-bromobenzo-1H-triazoles as inhibitors of human protein kinase CK2α.

    Directory of Open Access Journals (Sweden)

    Romualda Wąsik

    Full Text Available To further clarify the role of the individual bromine atoms of 4,5,6,7-tetrabromotriazole (TBBt, a relatively selective inhibitor of protein kinase CK2, we have examined the inhibition (IC(50 of human CK2α by the two mono-, the four di-, and the two tri- bromobenzotriazoles relative to that of TBBt. Halogenation of the central vicinal C(5/C(6 atoms proved to be a key factor in enhancing inhibitory activity, in that 5,6-di-Br(2Bt and 4,5,6-Br(3Bt were almost as effective inhibitors as TBBt, notwithstanding their marked differences in pK(a for dissociation of the triazole proton. The decrease in pK(a on halogenation of the peripheral C(4/C(7 atoms virtually nullifies the gain due to hydrophobic interactions, and does not lead to a decrease in IC(50. Molecular modeling of structures of complexes of the ligands with the enzyme, as well as QSAR analysis, pointed to a balance of hydrophobic and electrostatic interactions as a discriminator of inhibitory activity. The role of halogen bonding remains debatable, as originally noted for the crystal structure of TBBt with CK2α (pdb1j91. Finally we direct attention to the promising applicability of our series of well-defined halogenated benzotriazoles to studies on inhibition of kinases other than CK2.

  15. Mono-, di-, and tri- tert-butyl ethers of glycerol . A molecular spectroscopic study

    Science.gov (United States)

    Jamróz, Małgorzata E.; Jarosz, Małgorzata; Witowska-Jarosz, Janina; Bednarek, Elżbieta; Tęcza, Witold; Jamróz, Michał H.; Dobrowolski, Jan Cz.; Kijeński, Jacek

    2007-07-01

    MS, NMR, IR and Raman molecular spectroscopy techniques were applied to characterize 3- tert-butoxy-propane-1,2-diol, 1,3-di- tert-butoxy-propan-2-ol, and 1,2,3-tri- tert-butoxy-propane. These ethers are the main products of glycerol etherification reaction and are excellent oxygen additives for diesel fuel. Computational DFT/ B3LYP/6-31G ** studies were performed to support and rationalize both vibrational spectroscopy analysis and the isomer ratio.

  16. Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20 when used as flavourings for all animal species

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP

    2013-05-01

    Full Text Available Chemical group 20 consists of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups, of which 31 are currently authorised for use as flavours in food. The FEEDAP Panel was unable to perform an assessment of six compounds (methanethiol, methyl propyl disulphide, dipropyl trisulphide, 3-mercaptobutan-2-one, 3-(methylthiobutanal and 3-methyl-1,2,4-trithiane because of issues related to the purity of the compounds. The FEEDAP Panel concludes that the following 25 compounds are safe for the target species at the proposed maximum dose level (0.05 mg/kg complete feed: 3-(methylthiopropionaldehyde, methyl 3-(methylthiopropionate, allylthiol, dimethyl sulphide, dibutyl sulphide, diallyl disulphide, diallyl trisulphide, dimethyl trisulphide, dipropyl disulphide, allyl isothiocyanate, dimethyl disulphide, 2-methylbenzene-1-thiol, S-methyl butanethioate, allyl methyl disulphide, 3-(methylthiopropan-1-ol, 3-(methylthiohexan-1-ol, 1-propane-1-thiol, diallyl sulphide, 2,4-dithiapentane, 2-methyl-2-(methyldithiopropanal, 2-methylpropane-1-thiol, methylsulfinylmethane, propane-2-thiol, 3,5-dimethyl-1,2,4-trithiolane and 2-methyl-4-propyl-1,3-oxathiane. No safety concern for the consumer would arise from the use of these 25 compounds of CG 20 up to the highest safe level in feedingstuffs for all animal species, with the exception of allyl isothiocyanate. Although additional exposure to this substance through its low use level in animal feeds would not substantially increase consumer exposure, the FEEDAP Panel notes that the estimated exposure of consumers is already higher than the acceptable daily intake (ADI. All compounds should be considered irritant to skin, eyes and respiratory tract and as skin sensitisers. The proposed concentration of 0.05 mg flavour/kg feed is not expected to cause detrimental effects to the environment, except for 2-methylpropane-1-thiol, for which 0

  17. Dysprosium complexes with mono-/di-carboxylate ligands—From simple dimers to 2D and 3D frameworks

    International Nuclear Information System (INIS)

    Four dysprosium (Dy) single carboxylates, a formate, a propionate, a butyrate and an oxalate have been synthesized and structurally characterized. The structure of Dy(HCO2)3 (1) contains nine-fold coordinated Dy polyhedra in perfect tricapped trigonal prisms. They are linked through trigonal O atoms forming 1D pillars which are further linked together through tricapped O atoms into a 3D pillared metal organic framework. The network structure is stable up to 360 °C. The structure of [Dy2(C2O4)3(H2O)6]·2.5H2O (2) contains nine-fold coordinated Dy polyhedra linking together through μ2-bridging oxalate anions into a 2D hexagonal layered structure. Both [Dy2(Pr)6(H2O)4]·(HPr)0.5 (3) [Pr=(C2H5CO2)−1] and [Dy2(Bu)6(H2O)4] (4) [Bu=(C3H7CO2)−1] have similar di-nuclear structures. The Raman vibration modes of the complexes have been investigated. - Graphical abstract: Four dysprosium (Dy) complexes with formate, propionate, butyrate and oxalate ligands have been synthesized and characterized. The Dy formato complex has a 3D pillared metal organic framework and the structure is stable up to 360 °C whilst the complexes with longer alkyl chained mono-carboxylates possess similar di-nuclear structures. The Dy oxalato complex has a 2D hexagonal (honeycomb-type) structure. Their Raman vibration modes have been investigated. - Highlights: • New Dysprosium complexes with formate, propionate, butyrate and oxalate ligands. • Crystal structures range from dimers to two and three dimensional frameworks. • Vibrational modes have been investigated and correlated to the structures. • The complexes are thermal robust and stable to over 300 °C

  18. Photoluminescence study of tetra-dendron dendrimers derived from ethylenediamine cores and di-dendron dendrimers derived from mono-Boc-protected ethylenediamine cores

    International Nuclear Information System (INIS)

    Strong UV absorbance spectra and fluorescence spectra from tetra-dendron dendrimers derived from ethylenediamine cores with different terminal groups (-NH2, -COOCH3) or di-dendron dendrimers derived from mono-Boc-protected ethylenediamine cores were studied under different conditions by varying experimental parameters such as pH value and concentration. The result shows a rapid increase of fluorescence intensity at low pH. It was reasonable that the formation of a fluorescence-emitting moiety had a close relationship to protonated tertiary amine groups in tetra-dendron dendrimers derived from ethylenediamine cores or di-dendron dendrimers derived from mono-Boc-protected ethylenediamine cores. Furthermore, it was confirmed that the concentration of two dendrimers plays an important role in fluorescence intensity. The increase in fluorescence intensity was linear with respect to concentration at low concentration regions but the intensity increases slowly at high concentration regions.

  19. Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet

    DEFF Research Database (Denmark)

    Pedersen, Natalia; Vegh, Zsuzsanna; Burisch, Johan;

    2014-01-01

    In the present study we report on changes in irritable bowel syndrome-severity scoring system (IBS-SSS) and irritable bowel syndrome-quality of life (IBS-QoL) in 19 IBS patients, aged 18 to 74 years (F/M: 14/5), during 12 wk registering their symptoms on the web-application (www.......ibs.constant-care.dk). During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention. Thereafter, low fermentable oligo-, di-, mono-saccharides and polyols (FODMAP) diet (LFD) was introduced for the next 6 wk while continuing...... significantly during the LFD period, median: 67 (37-120), P < 0.01. The significant reduction in disease activity during the control period shows a positive effect of the web-application on IBS symptoms when presented as a "traffic light". However adding the diet reduced IBS-SSS to < 150, inactive to mild...

  20. Effect of mono-, di- and tri-ethanolammonium tetrafluoroborate protonic ionic liquids on vapour liquid equilibria of ethanol aqueous solution

    International Nuclear Information System (INIS)

    Vapour pressures were measured using a quasi-static ebulliometer for the binary mixture of (water + ethanol) containing one of three protonic ionic liquids (PIL), namely, mono-, di- or tri-ethanolammonium tetrafluoroborate, over the temperature range of (318.24 to 356.58) K at fixed PIL content of 0.30 in mass fraction. The vapour pressure data of the PIL-containing ternary systems were correlated using the NRTL equation with an overall root mean square deviation (RMSD) of 0.0092. The regressed NRTL parameters were used to predict the isobaric vapour liquid equilibria (VLE) for ternary systems (water + ethanol + PIL) at varying mass fraction of PIL and atmospheric pressure (101.3 kPa). It is shown that the effect of PILs on the VLE of the (water + ethanol) mixture follows the order: [HTEA][BF4] > [HDEA][BF4] > [HMEA][BF4]. In addition, the relative volatilities of ethanol to water for pseudo-binary systems (water + ethanol + PIL) were calculated. The results indicate that the PILs studied can enhance the relative volatility of ethanol to water and even break the azeotropic behaviour of ethanol aqueous solution when PIL content is increased to a specified content.

  1. Effect of mono-, di- and tri-ethanolammonium tetrafluoroborate protonic ionic liquids on vapour liquid equilibria of ethanol aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Shen Chong [State Key Laboratory of Chemical Resource Engineering and College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029 (China); Ma Xiaoyan [College of Science, Beijing University of Chemical Technology, Beijing 100029 (China); Lu Yingzhou [State Key Laboratory of Chemical Resource Engineering and College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029 (China); Li Chunxi, E-mail: Licx@mail.buct.edu.c [State Key Laboratory of Chemical Resource Engineering and College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029 (China)

    2011-03-15

    Vapour pressures were measured using a quasi-static ebulliometer for the binary mixture of (water + ethanol) containing one of three protonic ionic liquids (PIL), namely, mono-, di- or tri-ethanolammonium tetrafluoroborate, over the temperature range of (318.24 to 356.58) K at fixed PIL content of 0.30 in mass fraction. The vapour pressure data of the PIL-containing ternary systems were correlated using the NRTL equation with an overall root mean square deviation (RMSD) of 0.0092. The regressed NRTL parameters were used to predict the isobaric vapour liquid equilibria (VLE) for ternary systems (water + ethanol + PIL) at varying mass fraction of PIL and atmospheric pressure (101.3 kPa). It is shown that the effect of PILs on the VLE of the (water + ethanol) mixture follows the order: [HTEA][BF{sub 4}] > [HDEA][BF{sub 4}] > [HMEA][BF{sub 4}]. In addition, the relative volatilities of ethanol to water for pseudo-binary systems (water + ethanol + PIL) were calculated. The results indicate that the PILs studied can enhance the relative volatility of ethanol to water and even break the azeotropic behaviour of ethanol aqueous solution when PIL content is increased to a specified content.

  2. Effect of Mono-and Di-ethanolammonium Formate Ionic Liquids on the Volatility of Water, Ethanol, and Methanol

    Institute of Scientific and Technical Information of China (English)

    李雪梅; 沈冲; 李春喜

    2013-01-01

    Vapor pressures were measured for six binary systems containing water, ethanol, or methanol with one of the two ionic liquids (ILs) at different component concentrations and temperatures using a quasi-static ebulliometer, with the ILs mono-ethanolammonium formate ([HMEA][HCOO]) and di-ethanolammonium formate ([HDEA][HCOO]). The vapor pressures of the IL-containing binary systems are well correlated using the NRTL model with an overall average absolute relative deviation (AARD) of 0.0062. The effect of ILs on the vapor pressure depression of sol-vents at 0.050 mole fraction of IL is that [HDEA][HCOO]>[HMEA][HCOO], and the vapor pressure lowering de-gree follows the order of water>methanol>ethanol. Further, the activity coefficients of three solvents (viz. water, ethanol, and methanol) for the binary systems{solvent (1)+IL (2)}predicted based on the fitted NRTL parameters at T=333.15 K indicate that the two ILs generate a negative deviation from Raoult’s law for water and methanol and a positive deviation for ethanol to a varying degree, change the relative volatility of a solvent. [HMEA][HCOO] may be a promising entrainer to efficiently separate ethanol aqueous solutions by special rectification.

  3. Temperature dependence of the heat capacities in the solid state of 18 mono-, di-, and poly-saccharides

    International Nuclear Information System (INIS)

    The temperature dependence of the heat capacities in solid state Cp(T) of 18 mono-, di-, and poly-saccharides has been determined using a power-compensation differential scanning calorimeter. The saccharides were α-D-xylose, D-ribose, 2-deoxy-D-ribose, methyl-β-D-ribose, α-D-glucose, 2-deoxy-D-glucose, α-D-mannose, β-D-fructose, α-D-galactose, methyl-α-D-glucose, sucrose, maltose monohydrate, α-lactose monohydrate, cellobiose, maltotriose, N-acetyl-D-glucosamine, α-cyclodextrin, and β-cyclodextrin. The measurements were carried out at atmospheric pressure and from T = (288.15 to 358.15) K for 15 saccharides and from T = (288.15 to 328.15) K for D-ribose, 2-deoxy-D-ribose, and methyl-β-D-ribose. The present results are compared against literature values both at single temperatures, where most of the data are available, and throughout a range of temperatures, i.e., for Cp(T). The predictions of a recently published correlation for organic solids are briefly discussed. By grouping saccharides in subsets, our present results can be used to compare amongst saccharide isomers and to assess the effect of different chemical groups and molecular size

  4. Temperature dependence of the heat capacities in the solid state of 18 mono-, di-, and poly-saccharides

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez-Segura, Gerardo O. [Laboratorio de Biofisicoquimica, Departamento de Fisicoquimica, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico D.F. 04510 (Mexico); Campos, Myriam [Departamento de Quimica, Centro de Investigacion y Estudios Avanzados del I.P.N., Apdo. Postal 14-740, Mexico D.F. 07000 (Mexico); Costas, Miguel [Laboratorio de Biofisicoquimica, Departamento de Fisicoquimica, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico D.F. 04510 (Mexico)], E-mail: costasmi@servidor.unam.mx; Torres, Luis A. [Departamento de Quimica, Centro de Investigacion y Estudios Avanzados del I.P.N., Apdo. Postal 14-740, Mexico D.F. 07000 (Mexico)], E-mail: ltorres@cinvestav.mx

    2009-01-15

    The temperature dependence of the heat capacities in solid state C{sub p}(T) of 18 mono-, di-, and poly-saccharides has been determined using a power-compensation differential scanning calorimeter. The saccharides were {alpha}-D-xylose, D-ribose, 2-deoxy-D-ribose, methyl-{beta}-D-ribose, {alpha}-D-glucose, 2-deoxy-D-glucose, {alpha}-D-mannose, {beta}-D-fructose, {alpha}-D-galactose, methyl-{alpha}-D-glucose, sucrose, maltose monohydrate, {alpha}-lactose monohydrate, cellobiose, maltotriose, N-acetyl-D-glucosamine, {alpha}-cyclodextrin, and {beta}-cyclodextrin. The measurements were carried out at atmospheric pressure and from T = (288.15 to 358.15) K for 15 saccharides and from T = (288.15 to 328.15) K for D-ribose, 2-deoxy-D-ribose, and methyl-{beta}-D-ribose. The present results are compared against literature values both at single temperatures, where most of the data are available, and throughout a range of temperatures, i.e., for C{sub p}(T). The predictions of a recently published correlation for organic solids are briefly discussed. By grouping saccharides in subsets, our present results can be used to compare amongst saccharide isomers and to assess the effect of different chemical groups and molecular size.

  5. Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet.

    Science.gov (United States)

    Pedersen, Natalia; Vegh, Zsuzsanna; Burisch, Johan; Jensen, Lisbeth; Ankersen, Dorit Vedel; Felding, Maria; Andersen, Nynne Nyboe; Munkholm, Pia

    2014-06-01

    In the present study we report on changes in irritable bowel syndrome-severity scoring system (IBS-SSS) and irritable bowel syndrome-quality of life (IBS-QoL) in 19 IBS patients, aged 18 to 74 years (F/M: 14/5), during 12 wk registering their symptoms on the web-application (www.ibs.constant-care.dk). During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention. Thereafter, low fermentable oligo-, di-, mono-saccharides and polyols (FODMAP) diet (LFD) was introduced for the next 6 wk while continuing the registration. Though a small sample size a significant improvement in disease activity (IBS-SSS) was observed during both the control period, median: 278 (range: 122-377), P = 0.02, and subsequently during the LFD period, median: 151 (range: 29-334), P traffic light". However adding the diet reduced IBS-SSS to < 150, inactive to mild symptoms. In the future results from larger scale trials are awaited. PMID:24914395

  6. Equilibrium binding studies of mono, di and triisocyanide ligands on Au powder surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Ontko, A.

    1997-10-08

    The author`s group has previously shown that isocyanides are readily adsorbed from solutions to Au powder and bind to the Au surface in an end-on fashion through the terminal carbon. Later work demonstrated that the equilibrium constants for the reversible adsorption of electronically inequivalent isocyanides could be obtained using the Langmuir isotherm technique. This dissertation describes two projects completed which complement the initial findings of this group. Initially, several alkylisocyanides were synthesized to examine the effect of tail length on Au powder adsorption. It was observed that the length of the alkyl chain affected not only the Au surface binding affinity, but also the rate of surface saturation and saturation coverage values. Direct competition studies were also studied using a {sup 13}C-labeled isocyanide. These studies demonstrated the stabilization afforded by substrate-substrate packing forces in SAM`s formed by the longer chain isocyanides. In a second study, di and triisocyanides were synthesized to determine the effect that the length of the connecting link and the number of isocyanide groups (as points of attachment) have on Au adsorption stability. The work in this area describes the binding modes, relative binding affinities and surface coverage values for a series of flexible alkyl and xylyldiisocyanides on Au powder surfaces. This report contains only the introductory material, and general summary. Two chapters have been processed separately. 56 refs.

  7. Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro

    International Nuclear Information System (INIS)

    Any insult that affects survival of ovarian antral follicles can cause abnormal estradiol production and fertility problems. Phthalate esters (PEs) are plasticizers used in a wide range of consumer and industrial products. Exposure to these chemicals has been linked to reduced fertility in humans and animal models. Di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) decrease serum estradiol levels and aromatase (Arom) expression, prolong estrous cycles, and cause anovulation in animal and culture models. These observations suggest PEs directly target antral follicles. We therefore tested the hypothesis that DEHP (1-100 μg/ml) and MEHP (0.1-10 μg/ml) directly inhibit antral follicular growth and estradiol production. Antral follicles from adult mice were cultured with DEHP or MEHP, and/or estradiol for 96 h. During culture, follicle size was measured every 24 h as a measurement of follicle growth. After culture, media were collected for measurement of estradiol levels and follicles were subjected to measurement of cylin-D-2 (Ccnd2), cyclin-dependant-kinase-4 (Cdk4), and Arom. We found that DEHP and MEHP inhibited growth of follicles and decreased estradiol production compared to controls at the highest doses. DEHP and MEHP also decreased mRNA expression of Ccnd2, Cdk4, and Arom at the highest dose. Addition of estradiol to the culture medium prevented the follicles from DEHP- and MEHP-induced inhibition of growth, reduction in estradiol levels, and decreased Ccnd2 and Cdk4 expression. Collectively, our results indicate that DEHP and MEHP may directly inhibit antral follicle growth via a mechanism that partially includes reduction in levels of estradiol production and decreased expression of cell cycle regulators.

  8. Competitive separation of di- vs. mono-valent cations in electrodialysis: effects of the boundary layer properties.

    Science.gov (United States)

    Kim, Younggy; Walker, W Shane; Lawler, Desmond F

    2012-05-01

    In electrodialysis desalination, the boundary layer near ion-exchange membranes is the limiting region for the overall rate of ionic separation due to concentration polarization over tens of micrometers in that layer. Under high current conditions, this sharp concentration gradient, creating substantial ionic diffusion, can drive a preferential separation for certain ions depending on their concentration and diffusivity in the solution. Thus, this study tested a hypothesis that the boundary layer affects the competitive transport between di- and mono-valent cations, which is known to be governed primarily by the partitioning with cation-exchange membranes. A laboratory-scale electrodialyzer was operated at steady state with a mixture of 10mM KCl and 10mM CaCl(2) at various flow rates. Increased flows increased the relative calcium transport. A two-dimensional model was built with analytical solutions of the Nernst-Planck equation. In the model, the boundary layer thickness was considered as a random variable defined with three statistical parameters: mean, standard deviation, and correlation coefficient between the thicknesses of the two boundary layers facing across a spacer. Model simulations with the Monte Carlo method found that a greater calcium separation was achieved with a smaller mean, greater standard deviation, or more negative correlation coefficient. The model and experimental results were compared for the cationic transport number as well as the current and potential relationship. The mean boundary layer thickness was found to decrease from 40 to less than 10 μm as the superficial water velocity increased from 1.06 to 4.24 cm/s. The standard deviation was greater than the mean thickness at slower water velocities and smaller at faster water velocities. PMID:22336628

  9. Enhanced microemulsion formation in lipid-based drug delivery systems by combining mono-esters of medium-chain fatty acids with di- or tri-esters

    OpenAIRE

    Darshil P Patel; Ping Li; Abu T. M. Serajuddin

    2012-01-01

    To develop strategies for selecting appropriate lipids from mono-, di- and tri-esters of medium-chain fatty acids for the development of lipid-based drug delivery systems, ternary phase diagrams of propylene glycol(PG) monocaprylate (Capryol® 90; HLB~7), PG dicaprylocaprate (Labrafac™PG; HLB~2) and glycerol tricaprylocaprate (Labrafac™Lipophile WL1349; HLB~2) were determined in combination with a commonsurfactant, PEG-35 castor oil (Cremophor®EL, HLB~13), and water. Particle size and v...

  10. Metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) in rats: in vivo and in vitro dose and time dependency of metabolism

    International Nuclear Information System (INIS)

    This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally administered [14C]DEHP or [14C]MEHP at doses of 50 and 500 mg/kg body wt for three consecutive days. Urine was collected at 24-hr intervals, and metabolite profiles were determined. After a single dose of either compound, urinary metabolite profiles were similar to those previously reported. However, after multiple administration of both DEHP and MEHP at 500 mg/kg, increases in omega-/beta-oxidation products [metabolites I and V, mono(3-carboxy-2-ethylpropyl) phthalate and mono(5-carboxy-2-ethylpentyl) phthalate, respectively] and decreases in omega - 1-oxidation products [metabolites VI and IX, mono(2-ethyl-5-oxohexyl) phthalate and mono(2-ethyl-5-hydroxyhexyl) phthalate, respectively] were seen. At the low dose of 50 mg/kg little or no alteration in urinary metabolite profiles was observed. At 500 mg/kg of MEHP a 4-fold stimulation of CN- -insensitive palmitoyl-CoA oxidation (a peroxisomal beta-oxidation marker) was seen after three consecutive daily doses. At the low dose of 50 mg/kg only a 1.8-fold increase was noted. Similar observations were made with rat hepatocyte cultures. MEHP at concentrations of 50 and 500 microM was extensively metabolized in the rat hepatocyte cultures. Similar metabolic profiles to those seen after in vivo administration of MEHP were observed. At the high (500 microM) concentration of MEHP, changes in the relative proportions of omega- and omega- 1-oxidized metabolites were seen

  11. Effect of Mono- and Di-hydration on the Intramolecular Proton Transfers and Stability of Cyanuric Acid Isomers: A DFT Study

    Indian Academy of Sciences (India)

    YOUNES VALADBEIGI

    2016-08-01

    Structural and thermodynamic properties of 10 isomers of cyanuric acid were studied in aqueous and gas phases, employing B3LYP/6-311++G(d,p) method. The aromaticities of these isomers were evaluated using nucleus-independent chemical shift (NICS) index. The calculations showed that as the number of the ketogroups increases the stability of the isomers increases and the aromaticity decreases. Mono- and di-hydrations of the isomers did not change the stability trend, so that the tri-keto isomer was the most stable isomer amongthe hydrated and non-hydrated isomers. The activation energies (Ea) of the intramolecular proton transfers (tautomerisms) and energy barriers of H-rotations around its C-O axis in enolic isomers were calculated. The energy barriers were smaller than 45 kJ/mol for the H-rotations while the Ea values of the proton transfers were in the range of 130-210 kJ/mol. Effect of micro-hydrations on the transition state structures and the energy barriers of the tautomerisms were investigated. The mono- and di-hydrations lower the activation energies to100-130 kJ/mol and 110-145 kJ/mol, respectively.

  12. Synthesis and characterization of mono- and di-antimonide with the first transition metals in group 8B by mechanical alloying

    International Nuclear Information System (INIS)

    Mono- and di-anitimonide compounds between antimony and the first transition metals in group 8B were synthesized by mechanical alloying method. All samples were investigated by the X-ray powder diffraction technique and differential thermal analysis. The single phase can be obtained only for CoSb, NiSb and CoSb2 compounds. In this investigation, a single phase of a marcasite structure (FeSb2 and NiSb2) and Fe0.56Sb0.44 compound cannot be detected in the XRD patterns after 60 h of milling because of the instability of their structures at low temperature. They decomposed to their starting materials as seen by the characteristic peaks of the starting materials in the XRD patterns after 60 h of milling.

  13. Synthesis and characterization of mono- and di-antimonide with the first transition metals in group 8B by mechanical alloying

    Energy Technology Data Exchange (ETDEWEB)

    Amornpitoksuk, Pongsaton, E-mail: ampongsa@yahoo.co [Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla, 90112 (Thailand); Suwanboon, Sumetha [Department of Materials Science and Technology, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla, 90112 (Thailand); Ratana, Tanakorn [Industrial Chemistry Department, Faculty of Science, King Mongkut' s University of Technology North Bangkok, Bangkok, 10800 (Thailand); Ratana, Tanattha [Department of Physics, Faculty of Science, King Mongkut' s University of Technology Thonburi, Bangkok, 10140 (Thailand)

    2010-07-02

    Mono- and di-anitimonide compounds between antimony and the first transition metals in group 8B were synthesized by mechanical alloying method. All samples were investigated by the X-ray powder diffraction technique and differential thermal analysis. The single phase can be obtained only for CoSb, NiSb and CoSb{sub 2} compounds. In this investigation, a single phase of a marcasite structure (FeSb{sub 2} and NiSb{sub 2}) and Fe{sub 0.56}Sb{sub 0.44} compound cannot be detected in the XRD patterns after 60 h of milling because of the instability of their structures at low temperature. They decomposed to their starting materials as seen by the characteristic peaks of the starting materials in the XRD patterns after 60 h of milling.

  14. Modified interactions among globular proteins below isoelectric point in the presence of mono-, di- and tri-valent ions: A small angle neutron scattering study

    Science.gov (United States)

    Das, Kaushik; Kundu, Sarathi; Mehan, Sumit; Aswal, V. K.

    2016-02-01

    Both short range attraction and long range electrostatic repulsion exist among globular protein Bovine Serum Albumin in solution below its isoelectric point (pI ≈ 4.8). At pD ≈ 4.0, below pI, protein has a net positive surface charge although local charge inhomogeneity presents. Small angle neutron scattering study reveals that in the presence of both mono-(Na+) and di-(Ni2+) valent ions attractive interaction increases and repulsive interaction decreases with the increase of salt concentration. However, for tri-valent (Fe3+) ions, both attractive and repulsive interaction increases with increasing salt concentration but the relative strength of repulsion is more than the attraction.

  15. Alicyclic ammonium ionic liquids as lithium battery electrolytes A review

    OpenAIRE

    Puga, A.V.

    2013-01-01

    Ionic liquids are reasonable alternatives to electrolytes used in energy storage devices, such as lithium batteries, both lithium-ion and lithium-metal, given the safety advantages they provide. This is due to the favourable properties they often possess, mainly non­flammability and non­volatility. Candidates with alicyclic ammonium cations exhibit high electrochemical stabilities, especially towards lithium, a unique feature which enables the fabrication of reversible lithium-metal batteries...

  16. PET imaging of {alpha}{sub v}{beta}{sub 3} integrin expression in tumours with {sup 68}Ga-labelled mono-, di- and tetrameric RGD peptides

    Energy Technology Data Exchange (ETDEWEB)

    Dijkgraaf, Ingrid; Franssen, Gerben M.; Oyen, Wim J.G.; Boerman, Otto C. [Radboud University Nijmegen Medical Centre, Department of Nuclear Medicine, P.O. Box 9101, Nijmegen (Netherlands); Yim, Cheng-Bin [Radboud University Nijmegen Medical Centre, Department of Nuclear Medicine, P.O. Box 9101, Nijmegen (Netherlands); Utrecht University, Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht (Netherlands); Schuit, Robert C. [VU University Medical Centre, Department of Nuclear Medicine and PET Research, P.O. Box 7057, Amsterdam (Netherlands); Luurtsema, Gert [University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Hanzeplein 1, P.O. Box 30.001, Groningen (Netherlands); Liu, Shuang [Purdue University, School of Health Sciences, West Lafayette, IN (United States)

    2011-01-15

    Due to the restricted expression of {alpha}{sub v}{beta}{sub 3} in tumours, {alpha}{sub v}{beta}{sub 3} is considered a suitable receptor for tumour targeting. In this study the {alpha}{sub v}{beta}{sub 3}-binding characteristics of {sup 68}Ga-labelled monomeric, dimeric and tetrameric RGD peptides were determined and compared with their {sup 111}In-labelled counterparts. A monomeric (E-c(RGDfK)), a dimeric (E-[c(RGDfK)]{sub 2}) and a tetrameric (E{l_brace}E[c(RGDfK)]{sub 2}{r_brace}{sub 2}) RGD peptide were synthesised, conjugated with DOTA and radiolabelled with {sup 68}Ga. In vitro {alpha}{sub v}{beta}{sub 3}-binding characteristics were determined in a competitive binding assay. In vivo {alpha}{sub v}{beta}{sub 3}-targeting characteristics of the compounds were assessed in mice with subcutaneously growing SK-RC-52 xenografts. In addition, microPET images were acquired using a microPET/CT scanner. The IC{sub 50} values for the Ga(III)-labelled DOTA-E-c(RGDfK), DOTA-E-[c(RGDfK)]{sub 2} and DOTA-E{l_brace}E[c(RGDfK)]{sub 2}{r_brace}{sub 2} were 23.9 {+-} 1.22, 8.99 {+-} 1.20 and 1.74 {+-} 1.18 nM, respectively, and were similar to those of the In(III)-labelled mono-, di- and tetrameric RGD peptides (26.6 {+-} 1.15, 3.34 {+-} 1.16 and 1.80 {+-} 1.37 nM, respectively). At 2 h post-injection, tumour uptake of the {sup 68}Ga-labelled mono-, di- and tetrameric RGD peptides (3.30 {+-} 0.30, 5.24 {+-} 0.27 and 7.11 {+-} 0.67%ID/g, respectively) was comparable to that of their {sup 111}In-labelled counterparts (2.70 {+-} 0.29, 5.61 {+-} 0.85 and 7.32 {+-} 2.45%ID/g, respectively). PET scans were in line with the biodistribution data. On all PET scans, the tumour could be clearly visualised. The integrin affinity and the tumour uptake followed the order of DOTA-tetramer > DOTA-dimer > DOTA-monomer. The {sup 68}Ga-labelled tetrameric RGD peptide has excellent characteristics for imaging of {alpha}{sub v} {beta}{sub 3} expression with PET. (orig.)

  17. PET imaging of αvβ3 integrin expression in tumours with 68Ga-labelled mono-, di- and tetrameric RGD peptides

    International Nuclear Information System (INIS)

    Due to the restricted expression of αvβ3 in tumours, αvβ3 is considered a suitable receptor for tumour targeting. In this study the αvβ3-binding characteristics of 68Ga-labelled monomeric, dimeric and tetrameric RGD peptides were determined and compared with their 111In-labelled counterparts. A monomeric (E-c(RGDfK)), a dimeric (E-[c(RGDfK)]2) and a tetrameric (E{E[c(RGDfK)]2}2) RGD peptide were synthesised, conjugated with DOTA and radiolabelled with 68Ga. In vitro αvβ3-binding characteristics were determined in a competitive binding assay. In vivo αvβ3-targeting characteristics of the compounds were assessed in mice with subcutaneously growing SK-RC-52 xenografts. In addition, microPET images were acquired using a microPET/CT scanner. The IC50 values for the Ga(III)-labelled DOTA-E-c(RGDfK), DOTA-E-[c(RGDfK)]2 and DOTA-E{E[c(RGDfK)]2}2 were 23.9 ± 1.22, 8.99 ± 1.20 and 1.74 ± 1.18 nM, respectively, and were similar to those of the In(III)-labelled mono-, di- and tetrameric RGD peptides (26.6 ± 1.15, 3.34 ± 1.16 and 1.80 ± 1.37 nM, respectively). At 2 h post-injection, tumour uptake of the 68Ga-labelled mono-, di- and tetrameric RGD peptides (3.30 ± 0.30, 5.24 ± 0.27 and 7.11 ± 0.67%ID/g, respectively) was comparable to that of their 111In-labelled counterparts (2.70 ± 0.29, 5.61 ± 0.85 and 7.32 ± 2.45%ID/g, respectively). PET scans were in line with the biodistribution data. On all PET scans, the tumour could be clearly visualised. The integrin affinity and the tumour uptake followed the order of DOTA-tetramer > DOTA-dimer > DOTA-monomer. The 68Ga-labelled tetrameric RGD peptide has excellent characteristics for imaging of αv β3 expression with PET. (orig.)

  18. Mono Test

    Science.gov (United States)

    ... white blood cells and reactive lymphocytes on a blood smear in the presence of symptoms associated with mono indicates a likely diagnosis of infectious mononucleosis. A negative mono test requires ...

  19. What's Mono?

    Science.gov (United States)

    ... Quizzes Kids' Dictionary of Medical Words En Español What Other Kids Are Reading Back-to-School Butterflies? ... Got Homework? Here's Help White House Lunch Recipes What's Mono? KidsHealth > For Kids > What's Mono? Print A ...

  20. Biologically relevant mono- and di-nuclear manganese II/III/IV complexes of mononegative pentadentate ligands

    DEFF Research Database (Denmark)

    Baffert, Carole; Collomb, Marie-Nöelle; Deronzier, Alain; Kjærgaard-Knudsen, Sanne; Latour, Jean-Marc; Lund, Kirsten H.; McKenzie, Christine J.; Mortensen, Martin; Nielsen, Lars Preuss; Thorup, Niels

    Manganese(II) complexes of mononegative pentadentate N4O ligands [Mn2(mgbpen)(2)(H2O)(2)](ClO4)(2) (1), (mgbpen(-) = N-methyl-N'-glycyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine) and [Mn-2(bzgbpen)(2)(H2O)(2)](ClO4)(2) ( 2), (bzgbpen(-)=N-benzyl-N'-glycyl-N,N'-bis(2-pyridylmethyl)ethane-1......,2-diamine) have been prepared. The crystal structure of the Mn(II)-aqua complex of 1, shows it to be dimeric via (mu-kappaO)-bridging through one carboxylate oxygen atom of each of the two ligands. The non-coordinated carboxylate oxygen atoms are H-bonded to the water ligands on the adjacent Mn ion. The......-bridged dimanganese(III) and di-mu-oxo-dimanganese(II) complexes, depending on solvent. The [Mn(III)-OR](+), R = H or CH3 complexes are generated in water or methanol, respectively, and are potentially useful spectroscopic models for active Mn-lipoxygenases. In acetonitrile, di-mu-oxo-dimanganese(II) complexes are...

  1. Melamine-(H2SO4)3 and PVP-(H2SO4)n as solid acids:Synthesis and application in the first mono- and di-nitration of bisphenol A and other phenols

    Institute of Scientific and Technical Information of China (English)

    Gholamabbas Chehardoli; Mohammad Ali Zolfigol; Seyedeh Bahareh Azimi; Ebadollah Alizadeh

    2011-01-01

    Melamine and poly vinylpyrrolidone (PVP) reacted with neat sulfuric acid readily to form two new organic solid acids namely melamine-(H2SO4)3 and PVP-(H2SO4)n. These solid acids were used for the first nitration of bisphenol A as well as other phenols in the presence of NH4NO3. Mono- and di-nitro bisphenol A have been characterized with IR and 1H NMR techniques.

  2. A Comparative Evaluation of Mono-, Di- and Triglyceride of Medium Chain Fatty Acids by Lipid/Surfactant/Water Phase Diagram, Solubility Determination and Dispersion Testing for Application in Pharmaceutical Dosage Form Development

    OpenAIRE

    Hetal N. Prajapati; Dalrymple, Damon M.; Abu T. M. Serajuddin

    2011-01-01

    ABSTRACT Purpose To compare physiochemical properties of mono-, di- and triglycerides of medium chain fatty acids for development of oral pharmaceutical dosage forms of poorly water-soluble drugs using phase diagrams, drug solubility, and drug dispersion experiments. Methods Phase diagrams were prepared using a monoglyceride (glycerol monocaprylocaprate: Capmul MCM® EP), a diglyceride (glycerol dicaprylate) and two triglycerides (glycerol tricaprylate: Captex 8000®; caprylic/capric triglyceri...

  3. Design, synthesis and in vitro bactericidal/fungicidal screening of some vanadyl(IV)complexes with mono- and di-substituted ONS donor triazoles.

    Science.gov (United States)

    Sumrra, Sajjad H; Hanif, Muhammad; Chohan, Zahid H

    2015-01-01

    A new series of anti-bacterial and anti-fungal mono- and di-substituted triazoles (L(1))-(L(6)) have been synthesized and characterized on the basis of their physical, spectral and analytical data. The ligands (L(1))-(L(6)) on reaction with vanadyl(IV) sulphate led to the formation of vanadyl(IV) metal complexes (1)-(4). The structure of the complexes has been established on the basis of their physical, spectral and elemental analyses data. The synthesized ligands and their vanadyl(IV) complexes have been screened in vitro for anti-bacterial activity against six bacterial species such as, Escherichia coli (ATCC 25922), Shigella flexneri (ATCC 12022), Pseudomonas aeruginosa (ATCC 27853), Salmonella typhi (ATCC 14028), Staphylococcus aureus (ATCC 25923) and Bacillus subtilis (ATCC 6051) and for in vitro anti-fungal activity against six fungal strains, Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata. The screening results showed the vanadyl complexes to be more bactericidal/fungicidal against one or more bacterial/fungal species. The synthesized compounds were also subjected to brine shrimp bioassay for scrutinizing their cytotoxicity. PMID:25716124

  4. Enhanced microemulsion formation in lipid-based drug delivery systems by combining mono-esters of medium-chain fatty acids with di- or tri-esters

    Directory of Open Access Journals (Sweden)

    Darshil P Patel

    2012-06-01

    Full Text Available To develop strategies for selecting appropriate lipids from mono-, di- and tri-esters of medium-chain fatty acids for the development of lipid-based drug delivery systems, ternary phase diagrams of propylene glycol(PG monocaprylate (Capryol® 90; HLB~7, PG dicaprylocaprate (Labrafac™PG; HLB~2 and glycerol tricaprylocaprate (Labrafac™Lipophile WL1349; HLB~2 were determined in combination with a commonsurfactant, PEG-35 castor oil (Cremophor®EL, HLB~13, and water. Particle size and viscosity in different regions of the phase diagrams were measured, solubility of a model drug, danazol, in different lipid-surfactant mixtures was determined, and dispersion testing by diluting selected preconcentrates with 250 ml 0.01 NHCl was performed. Further, phase diagrams were constructed using binary mixtures of lipids (monoester with diester, or monoester with triester in place of single lipids. The phase diagrams of PG dicaprylocaprate andglycerol tricaprylocaprate were similar, while it was distinctly different for PG monocaprylate. The microemulsion regions in phase diagrams were rather limited for individual lipids, and additionally, the diand tri-esters showed pronounced gel regions in the phase diagrams, which could influence drug release from preconcentrates. The mixing of PG monocaprylate (monoester with PG dicaprylocaprate (diester or glycerol tricaprylocaprate (triester had dramatic effects on the performance of lipids as evidenced by thegreatly reduced gel phases, much larger microemulsion regions, faster dispersion of the preconcentrates in an aqueous medium, and smaller particle size of the microemulsions subsequently formed.

  5. Infrared and NMR (1H & 13C) Spectra of Sodium Salts of N-Bromo-Mono and Di-Substituted-Benzenesulphonamides

    Science.gov (United States)

    Gowda, B. Thimme; Usha, K. M.

    2003-06-01

    Fifteen sodium salts of mono and di-substituted N-bromobenzene-sulphonamides of the configuration, 4-X-C6H4SO2NaNBr (where X = H; CH3; C2H5; F; Cl; Br; or NO2) and i-X,j- YC6H3SO2NaNBr (where i-X, j-Y = 2,3-(CH3)2; 2,4-(CH3)2; 2,5-(CH3)2; 2-CH3,4-Cl; 2-CH3,5-Cl; 3-CH3,4-Cl; 2,4-Cl2 or 3,4-Cl2) are prepared and characterised by measuring their infrared spectra in the solid state and NMR spectra in solution. The N-Br vibrational frequencies, νN-Br of N-bromoarylsulphonamides vary in the range, 945 - 925 cm-1, while the N-Cl vibrational frequencies, νN-Cl, are observed in the range 950 - 927 cm-1 for the corresponding N-chloroarylsulphonamides. Asymmetric and symmetric SO2 stretching vibrations appear in the ranges, 1391 - 1352 cm-1 and 1148 - 1131 cm-1 for the monosubstituted N-bromoarylsulphonamides, while for the disubstituted N-bromocompounds they absorb in the ranges 1391 - 1331 cm-1 and 1149 - 1121 cm-1, respectively. The chemical shifts of aromatic protons and carbon-13 in all the N-bromoarylsulphonamides have been calculated by adding substituent contributions to the shift of benzene and compared with the observed values. The agreement between the calculated and experimental chemical shifts for different protons or carbon-13 is quite good.

  6. Blood burden of di(2-ethylhexyl) phthalate and its primary metabolite mono(2-ethylhexyl) phthalate in pregnant and nonpregnant rats and marmosets

    International Nuclear Information System (INIS)

    A comparison of the dose-dependent blood burden of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in pregnant and nonpregnant rats and marmosets is presented. Sprague-Dawley rats and marmosets were treated orally with 30 or 500 mg DEHP/kg per day, nonpregnant animals on 7 (rats) and 29 (marmosets) consecutive days, pregnant animals on gestation days 14-19 (rats) and 96-124 (marmosets). In addition, rats received a single dose of 1000 mg DEHP/kg. Blood was collected up to 48 h after dosing. Concentrations of DEHP and MEHP in blood were determined by GC/MS. In rats, normalized areas under the concentration-time curves (AUCs) of DEHP were two orders of magnitude smaller than the normalized AUCs of the first metabolite MEHP. Metabolism of MEHP was saturable. Repeated DEHP treatment and pregnancy had only little influence on the normalized AUC of MEHP. In marmosets, most of MEHP concentration-time courses oscillated. Normalized AUCs of DEHP were at least one order of magnitude smaller than those of MEHP. In pregnant marmosets, normalized AUCs of MEHP were similar to those in nonpregnant animals with the exception that at 500 mg DEHP/kg per day, the normalized AUCs determined on gestation days 103, 117, and 124 were distinctly smaller. The maximum concentrations of MEHP in blood of marmosets were up to 7.5 times and the normalized AUCs up to 16 times lower than in rats receiving the same daily oral DEHP dose per kilogram of body weight. From this toxicokinetic comparison, DEHP can be expected to be several times less effective in the offspring of marmosets than in that of rats if the blood burden by MEHP in dams can be regarded as a dose surrogate for the MEHP burden in their fetuses

  7. Alicyclic polyimides - a colorless and thermally stable polymer for opto-electronic devices

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Toshihiko; Mikami, Daisuke; Hashimoto, Takahiro; Kaise, Motoaki; Takahashi, Risa; Kawabata, Shuichi [Center for Nano Science and Technology, Tokyo Polytechnic University, 1583 Iiyama, Atsugi, Kanagawa 243-0297 (Japan)], E-mail: matumoto@nano.t-kougei.ac.jp

    2009-09-01

    Alicyclic polyimides were prepared from polyalicyclic monomers using a two-step method. Light absorption of polyimides was elucidated from quantum chemistry. The alicyclic polyimide films were colorless, and the transparencies in the visible region were over 85%. The semi-aromatic polyimide films had an average refractive index range of 1.599 to 1.617, and that of a full-alicyclic polyimide was 1.522. The birefringencies were nearly zero. Semi-aromatic polyimides were soluble in aprotic polar solvents like DMAc. However, the non-aromatic (full-alicyclic) polyimides were insoluble except sulfuric acid. All the alicyclic polyimides have the 5% weight loss temperatures in nitrogen over 450 deg. C, and 400 deg. C in air. They possess glass transition temperatures over 280 deg. C. The alicyclic polyimide films have a tensile modulus range of 1.3-3.0 GPa, and a tensile strength range of 38-145 MPa. Especially semi-aromatic polyimide films display high strength. They have an elongation at break range 5-30%. All the polyimides exhibited amorphous patterns and broad dispersive peaks of diffraction around at 16 deg. (2{theta})

  8. Alicyclic polyimides - a colorless and thermally stable polymer for opto-electronic devices

    International Nuclear Information System (INIS)

    Alicyclic polyimides were prepared from polyalicyclic monomers using a two-step method. Light absorption of polyimides was elucidated from quantum chemistry. The alicyclic polyimide films were colorless, and the transparencies in the visible region were over 85%. The semi-aromatic polyimide films had an average refractive index range of 1.599 to 1.617, and that of a full-alicyclic polyimide was 1.522. The birefringencies were nearly zero. Semi-aromatic polyimides were soluble in aprotic polar solvents like DMAc. However, the non-aromatic (full-alicyclic) polyimides were insoluble except sulfuric acid. All the alicyclic polyimides have the 5% weight loss temperatures in nitrogen over 450 deg. C, and 400 deg. C in air. They possess glass transition temperatures over 280 deg. C. The alicyclic polyimide films have a tensile modulus range of 1.3-3.0 GPa, and a tensile strength range of 38-145 MPa. Especially semi-aromatic polyimide films display high strength. They have an elongation at break range 5-30%. All the polyimides exhibited amorphous patterns and broad dispersive peaks of diffraction around at 16 deg. (2θ).

  9. NF EN 14105. July 2003. Fatty compounds derived products. Fatty acids methylic esters (FAME). Determination of the free- and total-glycerol content and of the mono-, di-, and triglycerides content. Reference method; NF EN 14105. Juillet 2003. Produits derives des corps gras. Esters methyliques d'acides gras (EMAG). Determination de la teneur en glycerols libre et total et en mono-, di- et triglycerides. Methode de reference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This European standard specifies a method of determination of the free glycerol and of the residual mono-, di-, and triglycerides content in fatty acids methylic esters (FAME) which will be incorporated in mineral oils. The total glycerol content is then determined from the obtained results. This method is adapted to colza, sunflower and soja oil FAMEs but not to copra or palm oil-based FAMEs because of the risk of peak superimposition. This method involves dangerous compounds, operations and equipments which are not considered in the text of the standard. (J.S.)

  10. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister; Lund, Pia; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    publication of the last revision of this FGE, the EFSA has been requested to evaluate 10 additional substances, which have been included in the present revision of FGE.08. For the substances methyl methanethiosulphonate [FL-no: 12.159], 2-methylbutane-2-thiol [FL-no: 12.172], 2-methylpropane-2- thiol [FL......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since the.......112, 12.116, 12.120, 12.164, 12.167, 12.199, 15.007, 15.102 and 15.125 and 15.134], evaluated through the Procedure, no appropriate NOAEL was available and additional data are required. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also...

  11. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 08, Revision 5 (FGE.08Rev5): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister; Lund, Pia; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since the...... publication of the last revision of this FGE, the EFSA has been requested to evaluate additional toxicological data submitted for two flavouring substances, one on supporting substance 2,5-dihydroxy-2,5-dimethyl-1,4-dithiane [FL-no: 15.006], which support the evaluation of the candidate substance 2...... present revision of FGE.08. For the substances methyl methanethiosulphonate [FL-no: 12.159], 2-methylbutane-2-thiol [FL-no: 12.172], 2-methylpropane-2-thiol [FL-no: 12.174], ethyl-2-mercapto-2-methyl propanoate [FL-no: 12.304] and 2,4,4-trimethyl-1,3-oxathiane [FL-no: 16.057] there is an indication of a...

  12. EFSA ; Scientific Opinion on Flavouring Group Evaluation 91, Revision 1 (FGE.91Rev1): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev3 (2011)

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister;

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... have also been considered for the substances evaluated through the Procedure and for three substances, [FL-no: 12.274, 12.284 and 15.049], information on the composition of stereoisomeric mixture is lacking....

  13. Stable TeV - Black Hole Remnants at the LHC: Discovery through Di-Jet Suppression, Mono-Jet Emission and a Supersonic Boom in the Quark-Gluon Plasma

    CERN Document Server

    Stöcker, H

    2006-01-01

    The production of Large Extra Dimension (LXD) Black Holes (BHs), with a new, fundamental mass scale of $M_f = 1$ TeV, has been predicted to occur at the Large Hadron Collider, LHC, with the formidable rate of $10^8$ per year in p-p collisions at full energy, 14 TeV, and at full luminosity. We show that such LXD-BH formation will be experimentally observable at the LHC by the complete disappearance of all very high $p_t$ ($> 500$ GeV) back-to-back correlated Di-Jets of total mass $M > M_f = 1$ TeV. We suggest to complement this clear cut-off signal at $M > 2*500$ GeV in the di-jet-correlation function by detecting the subsequent, Hawking-decay products of the LXD-BHs, namely either multiple high energy ($> 100$ GeV) SM Mono-Jets (i.e. away-side jet missing), sprayed off the evaporating BHs isentropically into all directions or the thermalization of the multiple overlapping Hawking-radiation in a Heckler-Kapusta-Plasma. Microcanonical quantum statistical calculations of the Hawking evaporation process for these...

  14. Palladium-catalysed transannular C-H functionalization of alicyclic amines

    Science.gov (United States)

    Topczewski, Joseph J.; Cabrera, Pablo J.; Saper, Noam I.; Sanford, Melanie S.

    2016-03-01

    Discovering pharmaceutical candidates is a resource-intensive enterprise that frequently requires the parallel synthesis of hundreds or even thousands of molecules. C-H bonds are present in almost all pharmaceutical agents. Consequently, the development of selective, rapid and efficient methods for converting these bonds into new chemical entities has the potential to streamline pharmaceutical development. Saturated nitrogen-containing heterocycles (alicyclic amines) feature prominently in pharmaceuticals, such as treatments for depression (paroxetine, amitifadine), diabetes (gliclazide), leukaemia (alvocidib), schizophrenia (risperidone, belaperidone), malaria (mefloquine) and nicotine addiction (cytisine, varenicline). However, existing methods for the C-H functionalization of saturated nitrogen heterocycles, particularly at sites remote to nitrogen, remain extremely limited. Here we report a transannular approach to selectively manipulate the C-H bonds of alicyclic amines at sites remote to nitrogen. Our reaction uses the boat conformation of the substrates to achieve palladium-catalysed amine-directed conversion of C-H bonds to C-C bonds on various alicyclic amine scaffolds. We demonstrate this approach by synthesizing new derivatives of several bioactive molecules, including varenicline.

  15. Kinetics of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in blood and of DEHP metabolites in urine of male volunteers after single ingestion of ring-deuterated DEHP

    International Nuclear Information System (INIS)

    The plasticizer di(2-ethylhexyl) phthalate (DEHP) is suspected to induce antiandrogenic effects in men via its metabolite mono(2-ethylhexyl) phthalate (MEHP). However, there is only little information on the kinetic behavior of DEHP and its metabolites in humans. The toxikokinetics of DEHP was investigated in four male volunteers (28–61 y) who ingested a single dose (645 ± 20 μg/kg body weight) of ring-deuterated DEHP (DEHP-D4). Concentrations of DEHP-D4, of free ring-deuterated MEHP (MEHP-D4), and the sum of free and glucuronidated MEHP-D4 were measured in blood for up to 24 h; amounts of the monoesters MEHP-D4, ring-deuterated mono(2-ethyl-5-hydroxyhexyl) phthalate and ring-deuterated mono(2-ethyl-5-oxohexyl) phthalate were determined in urine for up to 46 h after ingestion. The bioavailability of DEHP-D4 was surprisingly high with an area under the concentration-time curve until 24 h (AUC) amounting to 50% of that of free MEHP-D4. The AUC of free MEHP-D4 normalized to DEHP-D4 dose and body weight (AUC/D) was 2.1 and 8.1 times, that of DEHP-D4 even 50 and 100 times higher than the corresponding AUC/D values obtained earlier in rat and marmoset, respectively. Time courses of the compounds in blood and urine of the volunteers oscillated widely. Terminal elimination half-lives were short (4.3–6.6 h). Total amounts of metabolites in 22-h urine are correlated linearly with the AUC of free MEHP-D4 in blood, the parameter regarded as relevant for risk assessment. -- Highlights: ► After DEHP intake, DEHP and MEHP in blood show oscillating time courses. ► Dose-related blood levels of DEHP are 50 times higher in humans than in rats. ► Dose-related blood levels of free MEHP are 2 times higher in humans than in rats. ► Elimination of DEHP and its metabolites is short with half-lives of 4.3-6.6 h.

  16. Kinetics of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in blood and of DEHP metabolites in urine of male volunteers after single ingestion of ring-deuterated DEHP

    Energy Technology Data Exchange (ETDEWEB)

    Kessler, Winfried, E-mail: kessler@helmholtz-muenchen.de [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); Numtip, Wanwiwa [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); Völkel, Wolfgang; Seckin, Elcim [Department of Chemical Safety and Toxicology, Bavarian Health and Food Safety Authority, Pfarrstrasse 3, D-80538 München (Germany); Csanády, György A. [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); Institut für Toxikologie und Umwelthygiene, Technische Universität München, München (Germany); Pütz, Christian [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); and others

    2012-10-15

    The plasticizer di(2-ethylhexyl) phthalate (DEHP) is suspected to induce antiandrogenic effects in men via its metabolite mono(2-ethylhexyl) phthalate (MEHP). However, there is only little information on the kinetic behavior of DEHP and its metabolites in humans. The toxikokinetics of DEHP was investigated in four male volunteers (28–61 y) who ingested a single dose (645 ± 20 μg/kg body weight) of ring-deuterated DEHP (DEHP-D{sub 4}). Concentrations of DEHP-D{sub 4}, of free ring-deuterated MEHP (MEHP-D{sub 4}), and the sum of free and glucuronidated MEHP-D{sub 4} were measured in blood for up to 24 h; amounts of the monoesters MEHP-D{sub 4}, ring-deuterated mono(2-ethyl-5-hydroxyhexyl) phthalate and ring-deuterated mono(2-ethyl-5-oxohexyl) phthalate were determined in urine for up to 46 h after ingestion. The bioavailability of DEHP-D{sub 4} was surprisingly high with an area under the concentration-time curve until 24 h (AUC) amounting to 50% of that of free MEHP-D{sub 4}. The AUC of free MEHP-D{sub 4} normalized to DEHP-D{sub 4} dose and body weight (AUC/D) was 2.1 and 8.1 times, that of DEHP-D{sub 4} even 50 and 100 times higher than the corresponding AUC/D values obtained earlier in rat and marmoset, respectively. Time courses of the compounds in blood and urine of the volunteers oscillated widely. Terminal elimination half-lives were short (4.3–6.6 h). Total amounts of metabolites in 22-h urine are correlated linearly with the AUC of free MEHP-D{sub 4} in blood, the parameter regarded as relevant for risk assessment. -- Highlights: ► After DEHP intake, DEHP and MEHP in blood show oscillating time courses. ► Dose-related blood levels of DEHP are 50 times higher in humans than in rats. ► Dose-related blood levels of free MEHP are 2 times higher in humans than in rats. ► Elimination of DEHP and its metabolites is short with half-lives of 4.3-6.6 h.

  17. Langmuir-Blodgett mono- and multilayers of (di)alkoxy-substituted poly(p-phenylenevinylene) precursor polymers. 2. Stability, transfer, and multilayer structure of (di)alkoxy-substituted precursor PPVs

    NARCIS (Netherlands)

    Hagting, J.G.; Vos, R.E.T.P. de; Sinkovics, K.; Vorenkamp, E.J.; Schouten, A.J.

    1999-01-01

    The Langmuir monolayer stability and transfer properties of (di)alkoxy-substituted precursor PPVs were studied. All polymers formed stable monolayers, but the packing of the monomeric units in the monolayer depended strongly on the substituents. The less closely packed monolayers can be transferred

  18. Mono-Schiff-base or di-Schiff-base? Synthesis, spectroscopic, X-ray structural and DFT study of a series of Schiff-bases derived from benzil dihydrazone

    Science.gov (United States)

    Tan, Xue-Jie; Hao, Xiu-Qi; Zhao, Qing-Zhe; Cheng, Shuang-Shuang; Xie, Wen-Long; Xing, Dian-Xiang; Liu, Yun; Song, Lai-Zhou

    2015-11-01

    A series of mono- and di-Schiff-bases based on Benzil Dihydrazone (BDH) were designed and synthesized to be set as the model compounds to explain which one should be the advanced product and which parameters will determine the end-product. As the first step of a series of investigations, this article presents the syntheses and characterization of five new Schiff-bases plus one preliminary reported Schiff-base, all derived from BDH. The compounds were characterized by single crystal (or conventional powder) X-ray diffractometry, elemental analysis, m.p., 1H NMR, 13C NMR, IR and UV-Vis. Structural features of the five new Schiff-bases are similar. For instance, all molecules are nonsymmetrical/symmetrical double helix with the torsion angle of two "half-parts" about 72-97°. The Ph-Cdbnd N-Ndbnd C-Ph moiety all exists in planar and anti form, indicating significant conjugation. The crystal structures appear to be stabilized by π-stacking between the aromatic rings, as well as by intermolecular hydrogen bonds and C-H … π stacking interactions. DFT calculations have been performed to explain the trend of the experimentally measured reaction yields. In the case of the studied systems by us, the type of Schiff-bases exhibits a clear dependence on the molar ratio of reactants if the products have similar stabilities. Otherwise the importance of reaction conditions will be weakened and the most stable product will be favored.

  19. Neurological Toxicity of Individual and Mixtures of Low Dose Arsenic, Mono and Di (n-butyl) Phthalates on Sub-Chronic Exposure to Mice.

    Science.gov (United States)

    Mao, Guanghua; Zhou, Zhaoxiang; Chen, Yao; Wang, Wei; Wu, Xueshan; Feng, Weiwei; Cobbina, Samuel Jerry; Huang, Jing; Zhang, Zhen; Xu, Hai; Yang, Liuqing; Wu, Xiangyang

    2016-03-01

    The objective of this study was to evaluate the toxicity of individual and mixtures of di(n-butyl) phthalates (DBP) and their active metabolite monobutyl phthalate (MBP) and arsenic (As) on spatial cognition associated with hippocampal apoptosis in mice. Mice were exposed, individually or in combination, to DBP (50 mg/kg body weight, intragastrically), MBP (50 mg/kg body weight, intragastrically), and As (10 mg/L, per os) for 8 weeks. The Morris water maze test showed that mice exposed to DBP/MBP combined with As exhibited longer escape latencies and the lower average number of crossing the platform. The As content in the hippocampus after As exposure increased as compared to those without As exposure. In mice exposed to DBP/MBP combined with As, pathological alterations and oxidative damage to the hippocampus were found. Expression of apoptosis-related protein: Bax and caspase-3 were significantly increased in the hippocampus, while there was no significant change in expression of Bcl-2. The results suggested that DBP and MBP combined with As can induce spatial cognitive deficits through altering the expression of apoptosis-related protein and As played a critical role in cognition impairments. And the joint exposure has antagonistic effect. PMID:26257159

  20. Stable TeV Black Hole Remnants at the Lhc:. Discovery Through Di-Jet Suppression, Mono-Jet Emission and a Supersonic Boom in the Quark-Gluon Plasma

    Science.gov (United States)

    Stöcker, H.

    The production of large extra dimension (LXD) black holes (BHs), with a new, fundamental mass scale of Mf = 1 TeV, has been predicted to occur at the Large Hadron Collider, LHC, with the formidable rate of 108 per year in p-p collisions at full energy, 14 TeV, and at full luminosity. We show that such LXD-BH formation will be experimentally observable at the LHC by the complete disappearance of all very high pt (> 500 GeV) back-to-back correlated Di-Jets of total mass M > Mf = 1 TeV, in the large detectors ALICE, ATLAS and CMS. We suggest complementing this clear cut-off signal at M > 2*500 GeV in the di-jet-correlation function by detecting the subsequent, Hawking-decay products of the LXD-BHs, namely either multiple high energy (> 100 GeV) SM Mono-Jets (i.e. away-side jet missing), sprayed off the evaporating BHs isentropically into all directions or the thermalization of the multiple overlapping Hawking-radiation in a Heckler-Kapusta-plasma: The extreme energy density of the Hawking Radiation may yield a Heckler-Kapusta-Hawking quark-gluon plasma of SM — and SUSY — particles at temperatures above the electroweak phase transition, which hydrodynamically (isentropically) evolves and cools until the quark-hadron phasetransition and chemical freezeout at T ~ 100 MeV is reached. Microcanonical quantum statistical calculations of the Hawking evaporation process for these LXD-BHs show that cold black hole remnants (BHRs) of mass ~ Mf remain leftover as the ashes of these spectacular di-jet-suppressed events. The BHRs are charged and can be detected as a track in the Central TPC of ALICE. Strong di-jet suppression is also expected with heavy ion beams at the LHC, due to quark-gluon-plasma induced jet attenuation at medium to low jet energies, pt supersonic bang in the "big bang" matter. We discuss the importance of the underlying strong collective flow — the gluon storm — of the QCD matter for the formation and evolution of these Machshock cones. We predict a

  1. Species-specific isotope dilution analysis of mono-, di, and tri-butyltin compounds in sediment using gas chromatography-inductively coupled plasma mass spectrometry with synthesized 118Sn-enriched butyltins.

    Science.gov (United States)

    Inagaki, Kazumi; Takatsu, Akiko; Watanabe, Takuro; Aoyagi, Yoshie; Okamoto, Kensaku

    2003-03-01

    A species-specific isotope dilution (ID) method is described for the determination of mono-, di, and tri-butyltin compounds in sediment by gas chromatography-inductively coupled plasma mass spectrometry (GC-ICP-MS), where the mixture of 118Sn-enriched butyltin compounds synthesized in our laboratory was used as a spike. A correction method for the mass bias, a quantitative extraction of the butyltins from sediment, and an assay for the concentration of the standard solution for the reverse ID procedure were investigated to achieve a reliable ID analysis. The spike solution was added with tri-propyltin (TPrT), and the butyltins were extracted by mechanical shaking into acetic acid-tropolone-toluene. The extracted butyltins were ethylated with sodium tetraethylborate and measured by GC-ICP-MS. The mass bias correction factor for the butyltins was calculated with the measured area ratio of 120Sn/118Sn of TPrT in each chromatographic run, and the correction was carried out. The mass bias was well corrected with this in-run correction (the standard uncertainties of the corrected 120Sn/118Sn for the butyltins were in the range 0.03-0.45%, typically 0.25%, with triplicate measurement corresponding to 0.02-0.37% mass bias). The extraction efficiency of mono-butyltin (MBT) from sediment was improved by using tropolone-toluene as the solvent. Well-defined standard solutions for the reverse-ID procedure could be obtained by an assay for the purities of the natural abundance butyltin chloride reagents used for preparing the standard solutions. Overall uncertainties associated with the present method were estimated, where the sediment certified reference materials, PACS-2 and BCR 646, were analyzed. The uncertainty arising from the extraction was the main contributor to the overall uncertainties for MBT and di-butyltin (DBT) determinations, while with the case of tri-butyltin (TBT) determination the uncertainties arising from the purity of TBT chloride reagent used for

  2. Biochemical Properties of a New Cold-Active Mono- and Diacylglycerol Lipase from Marine Member Janibacter sp. Strain HTCC2649

    OpenAIRE

    Dongjuan Yuan; Dongming Lan; Ruipu Xin; Bo Yang; Yonghua Wang

    2014-01-01

    Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1) from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity ...

  3. Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium

    International Nuclear Information System (INIS)

    Di(2-ethylhexyl)-phthalate (DEHP) is the most abundantly used phthalate derivative, inevitable environmental exposure of which is suspected to contribute to the increasing incidence of testicular dysgenesis syndrome in humans. Oxidative stress and mitochondrial dysfunction in germ cells are suggested to contribute to phthalate-induced disruption of spermatogenesis in rodents, and Leydig cells are one of the main targets of phthalates' testicular toxicity. Selenium is known to be involved in the modulation of intracellular redox equilibrium, and plays a critical role in testis, sperm, and reproduction. This study was aimed to investigate the oxidative stress potential of DEHP and its consequences in testicular cells, and examine the possible protective effects of selenium using the MA-10 mouse Leydig tumor cell line as a model. In the presence and absence of selenium compounds [30 nM sodium selenite (SS), and 10 μM selenomethionine (SM)], the effects of exposure to DEHP and its main metabolite mono(2-ethylhexyl)-phthalate (MEHP) on the cell viability, enzymatic and non-enzymatic antioxidant status, ROS production, p53 expression, and DNA damage by alkaline Comet assay were investigated. The overall results of this study demonstrated the cytotoxicity and genotoxicity potential of DEHP, where MEHP was found to be more potent than the parent compound. SS and SM produced almost the same level of protection against antioxidant status modifying effects, ROS and p53 inducing potentials, and DNA damaging effects of the two phthalate derivatives. It was thus shown that DEHP produced oxidative stress in MA-10 cells, and selenium supplementation appeared to be an effective redox regulator in the experimental conditions used in this study, emphasizing the critical importance of the appropriate selenium status.

  4. Hepatic and intestinal glucuronidation of mono(2-ethylhexyl) phthalate, an active metabolite of di(2-ethylhexyl) phthalate, in humans, dogs, rats, and mice: an in vitro analysis using microsomal fractions.

    Science.gov (United States)

    Hanioka, Nobumitsu; Isobe, Takashi; Kinashi, Yu; Tanaka-Kagawa, Toshiko; Jinno, Hideto

    2016-07-01

    Mono(2-ethylhexyl) phthalate (MEHP) is an active metabolite of di(2-ethylhexyl) phthalate (DEHP) and has endocrine-disrupting effects. MEHP is metabolized into glucuronide by UDP-glucuronosyltransferase (UGT) enzymes in mammals. In the present study, the hepatic and intestinal glucuronidation of MEHP in humans, dogs, rats, and mice was examined in an in vitro system using microsomal fractions. The kinetics of MEHP glucuronidation by liver microsomes followed the Michaelis-Menten model for humans and dogs, and the biphasic model for rats and mice. The K m and V max values of human liver microsomes were 110 µM and 5.8 nmol/min/mg protein, respectively. The kinetics of intestinal microsomes followed the biphasic model for humans, dogs, and mice, and the Michaelis-Menten model for rats. The K m and V max values of human intestinal microsomes were 5.6 µM and 0.40 nmol/min/mg protein, respectively, for the high-affinity phase, and 430 µM and 0.70 nmol/min/mg protein, respectively, for the low-affinity phase. The relative levels of V max estimated by Eadie-Hofstee plots were dogs (2.0) > mice (1.4) > rats (1.0) ≈ humans (1.0) for liver microsomes, and mice (8.5) > dogs (4.1) > rats (3.1) > humans (1.0) for intestinal microsomes. The percentages of the V max values of intestinal microsomes to liver microsomes were mice (120 %) > rats (57 %) > dogs (39 %) > humans (19 %). These results suggest that the metabolic abilities of UGT enzymes expressed in the liver and intestine toward MEHP markedly differed among species, and imply that these species differences are strongly associated with the toxicity of DEHP. PMID:26514348

  5. Toxicology of mono-, di-, and triethanolamine.

    Science.gov (United States)

    Knaak, J B; Leung, H W; Stott, W T; Busch, J; Bilsky, J

    1997-01-01

    The chemistry, biochemistry, toxicity, and industrial use of monoethanolamine (MEA), diethanolamine (DEA), and triethanolamine (TEA) are reviewed. The dual function groups, amino and hydroxyl, make them useful in cutting fluids and as intermediates in the production of surfactants, soaps, salts, corrosion control inhibitors, and in pharmaceutical and miscellaneous applications. In 1995, the annual U.S. production capacity for ethanolamines was 447,727 metric tons. The principal route of exposure is through skin, with some exposure occurring by inhalation of vapor and aerosols. MEA, DEA, and TEA in water penetrate rat skin at the rate of 2.9 x 10(-3), 4.36 x 10(-3) and 18 x 10(-3) cm/hr, respectively. MEA, DEA, and TEA are water-soluble ammonia derivatives, with pHs of 9-11 in water and pHa values of 9.3, 8.8, and 7.7, respectively. They are irritating to the skin, eyes, and respiratory tract, with MEA being the worst irritant, followed by DEA and TEA. The acute oral LD50s are 2.74 g/kg for MEA, 1.82 g/kg for DEA, and 2.34 g/kg for TEA (of bw), with most deaths occurring within 4 d of administration. MEA is present in nature as a nitrogenous base in phospholipids. These lipids, composed of glycerol, two fatty acid esters, phosphoric acid, and MEA, are the building blocks of biomembranes in animals. MEA is methylated to form choline, another important nitrogenous base in phospholipids and an essential vitamin. The rat dietary choline requirement is 10 mg kg-1 d-1; 30-d oral administration of MEA (160-2670 mg kg-1 d-1) to rats produced "altered" liver and kidney weights in animals ingesting 640 mg kg-1 d-1 or greater. Death occurred at dosages of 1280 mg kg-1 d-1. No treatment-related effects were noted in dogs administered as much as 22 mg kg-1 d-1 for 2 yr. DEA is not metabolized or readily eliminated from the liver or kidneys. At high tissue concentrations, DEA substitutes for MEA in phospholipids and is methylated to form phospholipids composed of N-methyl and N, N-dimethyl DEA. Dietary intake of DEA by rats for 13 wk at levels greater than 90 mg kg-1 d-1 resulted in degenerative changes in renal tubular epithelial cells and fatty degeneration of the liver. Similar effects were noted in drinking water studies. The findings are believed to be due to alterations in the structure and function of biomembranes brought about by the incorporation of DEA and methylated DEA in headgroups. TEA is not metabolized in the liver or incorporated into phospholipids. TEA, however, is readily eliminated in urine. Repeated oral administration to rats (7 d/wk, 24 wk) at dose levels up to and including 1600 mg kg-1 d-1 produced histopathological changes restricted to kidney and liver. Lesions in the liver consisted of cloudy swelling and occasional fatty changes, while cloudy swelling of the convoluted tubules and loop of Henle were observed in kidneys. Chronic administration (2 yr) of TEA in drinking water (0, 1%, or 2% w/v; 525 and 1100 mg kg-1 d-1 in males and 910 and 1970 mg kg-1 d-1 in females) depressed body and kidney weights in F-344 rats. Histopathological findings consisted of an "acceleration of so-called chronic nephropathy" commonly found in the kidneys of aging F-344 rats. In B6C3F1 mice, chronic administration of TEA in drinking water (0, 1%, or 2%) produced no significant change in terminal body weights between treated and control animals or gross pathological changes. TEA was not considered to be carcinogenic. Systemic effects in rats chronically administered TEA dermally (0, 32, 64, or 125 mg kg-1 d-1 in males; 0, 63, 125, or 250 mg kg-1 d-1 in females) 5 d/wk for 2 yr were primarily limited to hyperplasia of renal tubular epithelium and small microscopic adenomas. In a companion mouse dermal study, the most significant change was associated with nonneoplastic changes in livers of male mice consistent with chronic bacterial hepatitis. PMID:8956558

  6. Alicyclic Polyimides and the Application in Liquid Crystal Alignment Films%脂环族聚酰亚胺及其液晶取向膜材料

    Institute of Scientific and Technical Information of China (English)

    刘金刚; 何民辉; 王佛松; 杨士勇

    2001-01-01

    Recent progress in the research of alicyclic polyimides was reviewed.The classification and synthesis of the alicyclic monomers were discussed.At the same time,the synthesis chemistry and characterization of the part\\| and whole\\|alicyclic polyimides were described.Especially,the particularity in the synthesis of the whole\\|alicyclic was presented.As an important material used widely in the alignment of the liquid crystals,alicyclic polyimides were paid more and more attention in recent years.Therefore,the emphasis was placed on the applications of the alicyclic polyimides as liquid crystal display (LCD) alignment films.%综述了近年来在脂环族聚酰亚胺领域内的研究进展。从单体的合成方法和分类以及脂环族聚酰亚胺的合成方法和实际应用等几方面系统阐述了该领域的研究进展,并着重讨论了其作为液晶显示器取向膜材料中的应用。

  7. Mono Lake Excursion Reviewed

    Science.gov (United States)

    Liddicoat, J. C.; Coe, R. S.

    2007-05-01

    The Mono Lake Excursion as recorded in the Mono Basin, CA, has an older part that is about negative 30 degrees inclination and about 300 degrees declination during low relative field intensity. Those paleomagnetic directions are closely followed by greater than 80 degrees positive inclination and east declination of about 100 degrees during higher relative field intensity. A path of the Virtual Geomagnetic Poles (VGPs) for the older part followed from old to young forms a large clockwise loop that reaches 35 degrees N latitude and is centered at about 35 degrees E longitude. That loop is followed by a smaller one that is counterclockwise and centered at about 70 degrees N latitude and 270 degrees E longitude (Denham & Cox, 1971; Denham, 1974; Liddicoat & Coe, 1979). The Mono Lake Excursion outside the Mono Basin in western North America is recorded as nearly the full excursion at Summer Lake, OR (Negrini et al., 1984), and as the younger portion of steep positive inclination/east declination in the Lahontan Basin, NV. The overall relative field intensity during the Mono Lake Excursion in the Lahontan Basin mirrors very closely the relative field intensity in the Mono Basin (Liddicoat, 1992, 1996; Coe & Liddicoat, 1994). Using 14C and 40Ar/39Ar dates (Kent et al., 2002) and paleoclimate and relative paleointensity records (Zimmerman et al., 2006) for the Mono Lake Excursion in the Mono Basin, it has been proposed that the Mono Lake Excursion might be older than originally believed and instead be the Laschamp Excursion at about 40,000 yrs B.P. (Guillou et al., 2004). On the contrary, we favor a younger age for the Mono Lake Excursion, about 32,000 yrs B.P., using the relative paleointensity in the Mono Basin and Lahontan Basin and 14C dates from the Lahontan Basin (Benson et al., 2002). The age of about 32,000 yrs B.P. is also in accord with the age (32,000- 34,000 yrs B.P.) reported by Channell (2006) for the Mono Lake Excursion at ODP Site 919 in the Irminger Basin

  8. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 74, Revision 3 (FGE.74Rev3): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally, related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or wi thout Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08Rev5 (2012)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz; Lund, Pia; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 19 simple aliphatic sulphides and thiols evaluated by the JECFA at the 53rd meeting in 1999 and the 61st meeting in 2003. The substances were evaluated through a stepwise approach...... basis of the MSDI approach. For 10 candidate substances in FGE.74Rev3 [FL-no: 12.009, 12.013, 12.020, 12.023, 12.045, 12.074, 12.155, 12.169, 12.241 and 12.280] evaluated through the Procedure, the Panel concluded that additional toxicity data are required....

  9. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 91, Re vision 2 (FGE.91Rev2): Consid eration of simple aliphatic and aromatic sulphides and thiols evaluated by the JECFA (53rd and 68th meetings, ) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev5 (2012)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz; Lund, Pia; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 44 simple aliphatic and aromatic sulphides and thiols evaluated by the JECFA at the 53rd and the 68th meeting. The substances were evaluated through a stepwise approach that...

  10. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF); Scientific Opinion on Flavouring Group Evaluation 74, Revision 1 (FGE.74Rev1): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08Rev1 (2009)

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister;

    Member States. In particular, the Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565......-no: 12.009, 12.020, 12.045, 12.169, 12.238, 12.239 and 12.291] information on secondary components and/or composition of mixture is requested. For six substances [FL-no: 12.009, 12.020, 12.023, 12.045, 12.074 and 12.155] no solubility in ethanol and/or solubility in water is available. Finally, the...

  11. Scientific Opinion on Flavouring Group Evaluation 91, Revision 2 (FGE.91Rev2): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by the JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev5 (2012)

    OpenAIRE

    EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)

    2014-01-01

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 44 simple aliphatic and aromatic sulphides and thiols evaluated by the ...

  12. Scientific Opinion on Flavouring Group Evaluation 74, Revision 3 (FGE.74Rev3): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08Rev5 (2012)

    OpenAIRE

    EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)

    2014-01-01

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 19 simple aliphatic sulphides and thiols evaluated by the JECFA at the ...

  13. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF); Scientific Opinion on Flavouring Group Evaluation 74, Revision 1 (FGE.74Rev1): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08Rev1 (2009)

    OpenAIRE

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister; Lund, Pia; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    2011-01-01

    The European Food Safety Authority (EFSA) asked the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to dec...

  14. Reaction kinetics and modeling of photoinitiated cationic polymerization of an alicyclic based diglycidyl ether

    Energy Technology Data Exchange (ETDEWEB)

    Harikrishna, R., E-mail: r.harikrishna@ncl.res.in [Polymer Science and Engineering Division, National Chemical Laboratory, Pune 411008 (India); Ponrathnam, S. [Polymer Science and Engineering Division, National Chemical Laboratory, Pune 411008 (India); Tambe, S.S. [Chemical Engineering and Process Development Division, National Chemical Laboratory, Pune 411008 (India)

    2014-01-01

    Highlights: • Photocationic polymerization of alicyclic based diglycidyl ether was carried out. • Kinetic parameters were influenced by gelation and diffusional restrictions. • Applicability of autocatalytic model was established by nonlinear regression. • System showed higher activation energy than cycloaliphatic and aromatic diepoxides. -- Abstract: Photoinitiated cationic polymerization of cycloaliphatic diepoxides had received tremendous attention, while studies with lesser polymerizable diglycidyl ethers are comparatively less reported. The present work deals with the photoinitiated cationic polymerization of cyclohexane dimethanol diglycidyl ether followed by estimation of kinetic parameters. The effects of concentration of photoinitiator and temperature on curing performance were studied using photo differential scanning calorimeter or photo DSC with polychromatic radiation. It was observed that the rate of polymerization as well as ultimate conversion increased with increasing concentration of photoinitiator and temperature. The influences of gelation as well as diffusional restrictions have remarkable effect on cure performance. The kinetic parameters as per autocatalytic kinetic model were studied by Levenberg–Marquardt nonlinear regression method instead of conventional linear method for obtaining more accurate values of apparent rate constant. It was observed that the model fits with data from initial stages to almost towards the end of the reaction. The activation energy was found to be higher than the values reported for more reactive cycloaliphatic diepoxides. The value of pre-exponential factor increased with increase in activation energy showing influence of gelation at early stages of reaction.

  15. Stable TeV - black hole remnants at the LHC : discovery through di-jet suppression, mono-jet emission and a supersonic boom in the quark-gluon plasma

    OpenAIRE

    Stöcker, Horst

    2006-01-01

    The production of Large Extra Dimension (LXD) Black Holes (BHs), with a new, fundamental mass scale of M_f = 1 TeV, has been predicted to occur at the Large Hadron Collider, LHC, with the formidable rate of 10^8 per year in p-p collisions at full energy, 14 TeV, and at full luminosity. We show that such LXD-BH formation will be experimentally observable at the LHC by the complete disappearance of all very high p_t (> 500 GeV) back-to-back correlated Di-Jets of total mass M > M_f = 1 TeV. We s...

  16. Crystal structures of salts of mono- and triprotonated [3(6)]adamanzane, 1,5,9,13-tetraazatricyclo[7.7.3.3(5,13)]docosane, and equilibrium studies of the reactions between mono-, di- and triprotonated species, respectively, having none, one and two lone pairs pointing outwards

    DEFF Research Database (Denmark)

    Springborg, Johan; Pretzmann, Ulla; Olsen, Carl Erik; Søtofte, Inger

    1998-01-01

    species is slow on the NMR timescale (25 degrees C). The lifetime of the diprotonated species has been studied by the temperature dependence of its H-1 NMR spectrum, which at room temperature corresponds to C-3v symmetry but at higher temperature exhibits coalescence corresponding to an approach toward a......-ray diffraction techniques. In acidic solution i(+),i,i,i-H[3(6)]adz(+) reacts with one hydrogen ion and at the same time undergoes inversion at one nitrogen group to give the diprotonated species i(+),i,i,o(+)-H-2[3(6)]adz(2+) as shown by H-1 and C-13 NMR spectroscopy and glass-electrode measurements. The...... thermodynamic data for the concentration equilibrium constant for the protonation/inversion reaction are -log K-ial= 3.122(5) M, Delta H degrees(K-ial)=12.0(8) kJ mol(-1), Delta S degrees(K-ial)= -20(3) J mol(-1) K-1 (25 degrees C, I=1 M (Na,H)Cl. The equilibration reaction between the mono-and dipotonated...

  17. Synthesis of Yttrium and Aluminum Complexes Supported by a Mono-Substituted Ferrocene Ligand

    OpenAIRE

    Gao, Jun

    2015-01-01

    Ferrocene chelating ligands provide good stability of the resulting metal complexes and redox-switchable control in chemical processes catalyzed by those complexes. In comparison to traditional di-substituted ferrocene tetradentate ligands, mono-substituted tridentate ferrocene ligands may form metal complexes with a more open coordination sphere around the metal center that may allow an increased preference for substrate coordination. In addition, a mono-substituted ferrocene ligand allows t...

  18. How Long Is Mono Contagious?

    Science.gov (United States)

    ... en español ¿Por cuánto tiempo es contagiosa la mononucleosis? The way mono works in the body is ... Here's how it works: Mono is short for mononucleosis . It is caused by an infection with the ...

  19. Preparation of mono- and diacetyl 4,4′-dimethylbiphenyl and their corresponding carboxylic acids

    DEFF Research Database (Denmark)

    Titinchi, Salam J.J.; Kamounah, Fadhil S.; Abbo, Hanna S.

    2007-01-01

    Shape selective acetylation of 4,4′-dimethylbiphenyl using anhydrous aluminum chloride as catalyst is an effective route for the production of mono- and di-acetyl-4,4′-dimethylbiphenyl. Preparations, characterization and a catalytic study of the Friedel-Crafts acetylation of 4,4′-dimethylbiphenyl...... dimethylbiphenyls. In chloroalkane or carbon disulfide solvent, the yields of isomers were in the order: 2 -> 3-; in nitromethane 3-isomer predominated. On the other hand diacetylation of the hydrocarbon gave only the 2,3′-diacetyl isomer. The mono- and di-ketones are converted to the corresponding carboxylic acids...

  20. Biochemical Properties of a New Cold-Active Mono- and Diacylglycerol Lipase from Marine Member Janibacter sp. Strain HTCC2649

    Directory of Open Access Journals (Sweden)

    Dongjuan Yuan

    2014-06-01

    Full Text Available Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1 from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1, Penicillium camembertii lipase U-150 (PCL, and Aspergillus oryzae lipase (AOL. Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity.

  1. Biochemical properties of a new cold-active mono- and diacylglycerol lipase from marine member Janibacter sp. strain HTCC2649.

    Science.gov (United States)

    Yuan, Dongjuan; Lan, Dongming; Xin, Ruipu; Yang, Bo; Wang, Yonghua

    2014-01-01

    Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1) from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1), Penicillium camembertii lipase U-150 (PCL), and Aspergillus oryzae lipase (AOL). Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity. PMID:24927145

  2. The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats

    DEFF Research Database (Denmark)

    Dalgaard, M.; Nellemann, Christine Lydia; Lam, Henrik Rye; Sørensen, Ilona Kryspin; Ladefoged, Ole

    2001-01-01

    A single oral dose of 400 mg/kg body weight of mono(2-ethylhexyl)phthalate (MEHP), the testis toxic metabolite of di(2-ethylhexyl)phthalate. was given to 28-day-old male Wistar rats and the testis toxic effects were investigated 3, 6. and 12 h after exposure. Detachment and sloughing of germ cells...

  3. EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 51, Revision 1: Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by the JECFA (59th meeting) structurally related to alicyclic ketones secondary alcohols and related esters in FGE.09Rev3 (2011)

    OpenAIRE

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister; Lund, Pia; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    2012-01-01

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 20 alicyclic ketones and secondary alcohols and related esters evaluate...

  4. Festival nimega Mono / Ivar Sakk

    Index Scriptorium Estoniae

    Sakk, Ivar, 1962-

    2015-01-01

    Haapsalu graafilise disaini festival Haapsalu Linnagaleriis: sisaldab ülevaate- ja teemanäitust ning väikest sümpoosioni. Temaatilise aastanäituse motiiv on "MONO". Plakateid on ka välismaa tegijatelt. Kuraator Marko Kekishev

  5. Symmetrization of mono\\"ids as hypergroups

    OpenAIRE

    Henry, Simon

    2013-01-01

    We adapt the construction of the Grothendieck group associated to a commutative mono\\"id to handle idempotent mono\\"ids. Our construction works for a restricted class of commutative mono\\"ids, it agrees with the Grothendieck group construction in many cases and yields a hypergroup which solves the universal problem for morphisms to hypergroups. It gives the expected non-trivial hypergroup construction in the case of idempotent mono\\"ids.

  6. Localization of the Transpiration Barrier in the Epi- and Intracuticular Waxes of Eight Plant Species: Water Transport Resistances Are Associated with Fatty Acyl Rather Than Alicyclic Components.

    Science.gov (United States)

    Jetter, Reinhard; Riederer, Markus

    2016-02-01

    Plant cuticular waxes play a crucial role in limiting nonstomatal water loss. The goal of this study was to localize the transpiration barrier within the layered structure of cuticles of eight selected plant species and to put its physiological function into context with the chemical composition of the intracuticular and epicuticular wax layers. Four plant species (Tetrastigma voinierianum, Oreopanax guatemalensis, Monstera deliciosa, and Schefflera elegantissima) contained only very-long-chain fatty acid (VLCFA) derivatives such as alcohols, alkyl esters, aldehydes, and alkanes in their waxes. Even though the epicuticular and intracuticular waxes of these species had very similar compositions, only the intracuticular wax was important for the transpiration barrier. In contrast, four other species (Citrus aurantium, Euonymus japonica, Clusia flava, and Garcinia spicata) had waxes containing VLCFA derivatives, together with high percentages of alicyclic compounds (triterpenoids, steroids, or tocopherols) largely restricted to the intracuticular wax layer. In these species, both the epicuticular and intracuticular waxes contributed equally to the cuticular transpiration barrier. We conclude that the cuticular transpiration barrier is primarily formed by the intracuticular wax but that the epicuticular wax layer may also contribute to it, depending on species-specific cuticle composition. The barrier is associated mainly with VLCFA derivatives and less (if at all) with alicyclic wax constituents. The sealing properties of the epicuticular and intracuticular layers were not correlated with other characteristics, such as the absolute wax amounts and thicknesses of these layers. PMID:26644508

  7. A study on synthesis and oxidation mechanism of mono-alkyl phosphate

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Oxidation of white phosphorus by peroxides to produce mono-alkyl phosphate in the alcoholic solution has been studied under non-and catalytic conditions. In this paper,the mechanism of the oxidation process was analyzed. The content of mono-alkyl phosphate in the product is affected by different types of alcoholic solution and peroxide solvent. The result shows the availability of the following order for the activity of the peroxide solvent and alcoholic solutions-tert-butyl hydroperoxide>(di) benzoyl perox...

  8. Termofluidodinamica di un Getto di Litio

    OpenAIRE

    Nitti, Francesco Saverio

    2010-01-01

    Calcolo della superficie curvilinea di scorrimento di un getto di litio in maniera che la pressione lungo il getto vari in maniera lineare. Formulazione di un codice di calcolo per la determinazione delle diverse possibili superfici. Studio termofluidodinamico del getto con codici CFD. Accoppiamento tra codici di sistema e codici CFD. Valutazioni delle condizioni di Incipient Boiling per il litio.

  9. EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 51, Revision 1: Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by the JECFA (59th meeting) structurally related to alicyclic

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister; Lund, Pia; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 20 alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting) in 2002. This revision is made due to inclusion of seven additional substances...

  10. The impact of rubbing fabric type on surface roughness and tribological properties of some semi-alicyclic polyimides evaluated from atomic force measurements

    Science.gov (United States)

    Stoica, Iuliana; Barzic, Andreea Irina; Hulubei, Camelia

    2013-03-01

    The morphology of some polyimides (PI) prepared from a flexible and alicyclic dianhydride, in combination with aromatic diamines was investigated in detail before and after rubbing with two types of fabric: cotton velvet (CV) and cellulose diacetate velvet (CDV). Atomic force microscopy was employed to evaluate the correlation between rubbing-induced grooves in PI film and size/flexibility of textile fibers. For both samples surface isotropy decreased appreciatively with 91% after patterning since the appearance of ordered nanostructures in the direction of rubbing. The angular spectra reveal the generation of a surface anisotropy after rubbing process and a higher surface regularity and uniformity when using CV. This result is confirmed by decrease of texture direction index with 75% and of surface texture aspect ratio with 89%. These parameters together with the rubbing fiber characteristics are key factors in controlling liquid crystal alignment on patterned PI surfaces.

  11. The endocrine disruptor mono-(2-ethylhexyl)phthalate promotes adipocyte differentiation and induces obesity in mice

    OpenAIRE

    Chanjuan Hao; Xuejia Cheng; Hongfei Xia; Xu Ma

    2013-01-01

    The environmental obesogen hypothesis proposes that exposure to endocrine disruptors during developmental ‘window’ contributes to adipogenesis and the development of obesity. MEHP [mono-(2-ethylhexyl) phthalate], a metabolite of the widespread plasticizer DEHP [di-(2-ethylhexyl) phthalate], has been found in exposed organisms and identified as a selective PPARγ (peroxisome-proliferator-activated receptor γ) modulator. However, implication of MEHP on adipose tissue ...

  12. Thyroid Endocrine Disruption in Zebrafish Larvae after Exposure to Mono-(2-Ethylhexyl) Phthalate (MEHP)

    OpenAIRE

    Zhai, Wenhui; Huang, Zhigang; Chen, Li; Feng, Cong; Li, Bei; Li, Tanshi

    2014-01-01

    Phthalates are extensively used as plasticizers in a variety of daily-life products, resulting in widespread distribution in aquatic environments. However, limited information is available on the endocrine disrupting effects of phthalates in aquatic organisms. The aim of the present study was to examine whether exposure to mono-(2-ethylhexyl) phthalate (MEHP), the hydrolytic metabolite of di-(2-ethylhexyl) phthalate (DEHP) disrupts thyroid endocrine system in fish. In this study, zebrafish (D...

  13. Mono-(2-Ethylhexyl) Phthalate Induces Oxidative Stress and Inhibits Growth of Mouse Ovarian Antral Follicles1

    OpenAIRE

    Wang, Wei; Craig, Zelieann R.; Basavarajappa, Mallikarjuna S.; Hafner, Katlyn S.; Flaws, Jodi A.

    2012-01-01

    Mono-(2-ethylhexyl) phthalate (MEHP) is the active metabolite of the most commonly used plasticizer, di-(2-ethylhexyl) phthalate, and is considered to be a reproductive toxicant. However, little is known about the effects of MEHP on ovarian antral follicles. Thus, the present study tested the hypothesis that MEHP inhibits follicle growth via oxidative stress pathways. The data indicate that MEHP increases reactive oxygen species (ROS) levels and inhibits follicle growth in antral follicles, w...

  14. A study on synthesis and oxidation mechanism of mono-alkyl phosphate

    Institute of Scientific and Technical Information of China (English)

    Sheng Wang; Shu-yun Yan; Qing-guo Ye

    2009-01-01

    Oxidation of white phosphor, us by peroxides to produce mono-alkyl phosphate in the alcoholic solution has been studied under non-and catalytic conditions. In this paper, the mechanism of the oxidation process was analyzed. The content of mono-alkyl phosphalte in the product is affected by different types of alcoholic solution and peroxide solvent. The result shows the availabulity of the following order for the activity of the peroxide solvent and alcoholic solutions-tert-butyl hydroperoxide>(di) benzoyl peroxide>hydroperoxide; methanol> n-butyl alcohol> phenol. Under optimized reaction conditions: n (a white phosphorus) : n( tert-butyl hydroperoxide) : n (methanol)= 1:10:12, reaction temperature 80 ℃, reaction time 2.5 h, products of 80.0% mono-alkyl phosphonates can be provided when white phosphorus undergoes oxidation by tert-butyl hydroperoxide in the methanol solutions. When Cu (I), and Cn(Ⅱ) complexes are used as catalysts, it is possible to significantly enhance the oxidation of white phosphorus with the increase in the reaction rate. Th'e order for activity of catalysts is Cu(acac)2>Cu (CH3COO)2>Cu (C3 H7COO)2:>CuI>CuCI2. Noticeably, with Cu(acac)2 as catalyst, the selectivity for mono-alkyl phusphonates can reach 95% under adequate reaction conditions.

  15. Plasma etching on large-area mono-, multi- and quasi-mono crystalline silicon

    DEFF Research Database (Denmark)

    Davidsen, Rasmus Schmidt; Schmidt, Michael Stenbæk; Boisen, Anja;

    2013-01-01

    fabricated using maskless RIE in a O2 and SF6 plasma, and the surface topology was optimized for solar cell applications by varying gas flows, pressure, power and process time. The starting substrates were 156x156 mm p-type, CZ mono-, multi- and quasi-mono crystalline Si wafers, respectively, with a...

  16. Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2006-06-01

    Full Text Available Segnalazione di tesi di dottorato.Giusi BarbarottoL'immagine dei sovrani angioini di Napoli da Carlo I a Roberto (XIII-XIV secolo: propaganda e percezione della dinastia, Tesi di Dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2006 Marta L. Mangini "Reformetur et fiat collegium unum notariorum civitatis et episcopatus Cumarum". Notariato e documento notarile nell'antica diocesi di Como (secc. XIV ex.-XVI in., Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Milano, 2005 Nicola Montesano Gli insediamenti giovanniti nel Mezzogiorno d'Italia dalle origini al XVI secolo. Il Priorato di Barletta, Tesi di ottorato di ricerca in Storia del Mezzogiorno e dell'Europa Mediterranea dal Medioevo all'Età Contemporanea, Università degli Studi della Basilicata, 2005 Caterina OrlandoNobiltà urbana, ceti mercantili e governo cittadino a Siracusa in età aragonese (1282-1410, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2006 Marcello PacificoFederico II e il regno di Gerusalemme. Oriente e Occidente a confronto nella prima metà del XIII secolo, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2006 Maria Elisa SoldaniUomini d'affari e mercanti toscani a Barcellona nel XV secolo. Contributo alla storia del Mediterraneo bassomedievale, Tesi di dottorato di ricerca in Istituzioni società, religioni dal tardo-antico alla fine del Medioevo,Università degli Studi di Torino, 2006 Elvira VittozziMicheletto degli Attendoli condottiero nella guerra angioino-aragonese di Napoli (1435-1439, Tesi di dottorato di ricerca in Storia, Università di Napoli "Federico II", 2006

  17. Resonant mono Higgs at the LHC

    Science.gov (United States)

    Basso, Lorenzo

    2016-04-01

    In recent years, the production of a SM particle with large missing transverse momentum, dubbed mono-X searches, have gained increasing attention. After the discovery of the Higgs boson in 2012, the run-II of the LHC will now scrutinise its properties, looking for BSM physics. In particular, one could search for mono-Higgs signals, that are typically studied in models addressing dark matter. However, this signal can appear also in models addressing the neutrino masses, if additional heavier neutrinos with masses at the electroweak scale are present. The latter will couple to the SM neutrinos and the Higgs boson, yielding a type of mono-Higgs signal not considered for dark matter: the resonant production of a Higgs boson and missing energy. In this paper, we address the LHC exclusion power of the latter with dedicated detector simulations, and reinterpret it in a benchmark scenario for neutrino mass generation.

  18. Resonant mono Higgs at the LHC

    CERN Document Server

    Basso, Lorenzo

    2015-01-01

    In recent years, the production of a SM particle with large missing transverse momentum, dubbed mono-X searches, have gained increasing attention. After the discovery of the Higgs boson in 2012, the run-II of the LHC will now scrutinise its properties, looking for BSM physics. In particular, one could search for mono-Higgs signals, that are typically studied in models addressing dark matter. However, this signal can appear also in models addressing the neutrino masses, if additional heavier neutrinos with masses at the electroweak scale are present. The latter will couple to the SM neutrinos and the Higgs boson, yielding a type of mono-Higgs signal not considered for dark matter: the resonant production of a Higgs boson and missing energy. In this paper, we address the LHC exclusion power of the latter with dedicated detector simulations, and reinterpret it in a benchmark model for neutrino mass generation.

  19. Scientific Opinion on the safety and efficacy of aliphatic and alicyclic ethers (chemical group 16 when used as flavourings for all animal species

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP

    2012-11-01

    Full Text Available Chemical group 16 consists of aliphatic and alicyclic ethers, of which four are currently authorised for use as flavours in food. The FEEDAP Panel was unable to perform an assessment of 1,5,5,9-tetramethyl-13-oxatricyclo[8.3.0.0.(4.9]tridecane and theaspirane because of issues related to the purity of the compounds. The FEEDAP Panel concludes that: i1,8-cineole is safe at the high use level proposed by the applicant (5 mg/kg complete feed for all animal species with a margin of safety of 5.6 to 28.2; ii2-(2-methylprop-1-enyl-4-methyltetrahydropyran (Class II is safe at a maximum of 0.3 mg/kg complete feed for cattle, salmonids and non food producing animals and of 0.5 mg/kg complete feed for pigs and poultry. The absence of a margin of safety would not allow the simultaneous administration in feed and water for drinking of these substances. The total dose from all sources should not exceed that recommended when given in feed alone. No safety concern would arise for the consumer from the use of compounds belonging to CG 16 up to the highest safe level in feedingstuffs for all animal species. The FEEDAP Panel considers it prudent to treat both compounds under assessment as irritants to skin, eyes and respiratory tract, and as skin sensitisers. The FEEDAP Panel considers that the concentrations of the compounds belonging to CG 16 in the environment are not expected to exceed levels of concern when used in animal feeds at the levels considered to be safe to the target species. Since these compounds are used in food as flavourings, and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary.

  20. Gravity and magnetic investigations of the Mono-Inyo Volcanic Chain, Mono Basin, California

    Science.gov (United States)

    Pera, A. A.; Ponce, D. A.; McPhee, D. K.; Battaglia, M.

    2010-12-01

    The Mono Inyo volcanic chain is a 25-km long, north-south trending series of domes and craters extending southward from Mono Lake and into the west moat of Long Valley Caldera. Based on the Holocene history of eruptions in the area, the chain appears to hold the greatest potential for renewed magmatic activity (Hildreth, 2004). To better characterize the geometry and structure of Mono Basin for future dynamic modeling of the Mono Inyo volcanic chain a new gravity and magnetic survey was conducted. We collected gravity data at over 320 stations in and around the northern and central region of the Mono-Inyo volcanic chain and around Mono Lake in the summer of 2010. Regional gravity data was collected at one-mile spacing and data collected on profile lines was collected at quarter-mile intervals. We collected magnetic data on major roads along several transects across Mono Basin that include one coincident with a seismic refraction line (Hill and others, 1985). Rock samples were collected for analysis of density and magnetic susceptibility. The new gravity and magnetic data will be compiled with pre-existing data from studies dating back to the 1960’s (Pakiser and others, 1960, 1976; Christensen, 1969) to produce new isostatic gravity and magnetic anomaly maps. Preliminary isostatic gravity and magnetic maps from pre-existing data show the presence of gravity and magnetic lows in Mono Lake and Long Valley Caldera where low density volcanic sediments are prevalent; gravity highs were observed to the east and west of Mono Lake and to the east of Long Valley Caldera. A region with a high magnetic anomaly lies to the east of the volcanic chain. Two-dimensional forward modeling of potential field data along profiles that extend across Mono Basin will constrain the density and magnetization distribution, stratification and structural geology of the Mono-Inyo volcanic chain. These efforts are critical to improve dynamic modeling of Sierran range-front faulting and dike

  1. Mono versus Stereo: Bilingualism's Double Face.

    Science.gov (United States)

    Grutman, Rainier

    1993-01-01

    Offers an application of Mikhail Bakhtin's heteroglossia model, describing literature from a diversified point of view. Analyzes two examples to show nevertheless that Bakhtin unilaterally celebrates "stereo" qualities of language blending, and leaves no room for "mono" texts, which use polyglot devices as borders much more than as bridges between…

  2. Search for Exotic mono-jet and mono-photon signatures with the ATLAS detector

    Directory of Open Access Journals (Sweden)

    Rezvani Reyhaneh

    2013-05-01

    Full Text Available Mono-jet and mono-photon signatures are final states in a variety of scenarios beyond the Standard Model, such as the Large Extra Dimension models, gauge-mediated SUSY breaking scenarios, and models with pair production of Weakly Interacting Massive Particles considered as dark matter candidates. The produced exotic particles do not interact with the detector, resulting in missing transverse energy. The results of searches, performed in the ATLAS experiment at the LHC, for new physics in final states with an energetic jet or photon and large missing transverse energy are presented. The mono-jet search is performed using both 4.6 fb−1 of 7 TeV and 10.5 fb−1 of 8 TeV data, while the mono-photon results correspond to 4.6 fb−1 of 7 TeV data.

  3. Proposta di utilizzo di metodologie termografiche per il controllo di qualità di componenti meccanici

    Directory of Open Access Journals (Sweden)

    Roberto D’Andrea

    2010-04-01

    Full Text Available In base all’esperienza maturata in anni di sperimentazione sull’analisi delle caratteristiche meccaniche dei materiali mediante indagine termografica, nel presente lavoro è proposta una procedura per il controllo di qualità di componenti meccanici in linea di produzione, che è già stata argomento di brevetto. Lo sviluppo di questo lavoro si colloca nell’ambito del progetto FIRB Smart Reflex “Sistemi di produzione intelligenti, flessibili e riconfigurabili”. L’attività svolta dal DIIM riguarda il controllo avanzato dell’affidabilità di componenti meccanici per l’industria automobilistica. Viene proposta, quindi, la realizzazione di una cella di controllo in linea di produzione capace di valutare la presenza di eventuali componenti difettosi attraverso l’analisi termica degli stessi, sollecitati secondo un modello predefinito. L’attività, svolta in questa prima fase in laboratorio, è facilmente trasferibile in linea di produzione, considerando la possibilità di realizzare celle di prova in ambiente controllato, con condizioni praticamente identiche a quelle di laboratorio, eliminando gli effetti di disturbo che possono influenzare la risposta dell’indagine termografica in ambiente non strutturato.

  4. Localization of the Transpiration Barrier in the Epi- and Intracuticular Waxes of Eight Plant Species: Water Transport Resistances Are Associated with Fatty Acyl Rather Than Alicyclic Components1[OPEN

    Science.gov (United States)

    Jetter, Reinhard

    2016-01-01

    Plant cuticular waxes play a crucial role in limiting nonstomatal water loss. The goal of this study was to localize the transpiration barrier within the layered structure of cuticles of eight selected plant species and to put its physiological function into context with the chemical composition of the intracuticular and epicuticular wax layers. Four plant species (Tetrastigma voinierianum, Oreopanax guatemalensis, Monstera deliciosa, and Schefflera elegantissima) contained only very-long-chain fatty acid (VLCFA) derivatives such as alcohols, alkyl esters, aldehydes, and alkanes in their waxes. Even though the epicuticular and intracuticular waxes of these species had very similar compositions, only the intracuticular wax was important for the transpiration barrier. In contrast, four other species (Citrus aurantium, Euonymus japonica, Clusia flava, and Garcinia spicata) had waxes containing VLCFA derivatives, together with high percentages of alicyclic compounds (triterpenoids, steroids, or tocopherols) largely restricted to the intracuticular wax layer. In these species, both the epicuticular and intracuticular waxes contributed equally to the cuticular transpiration barrier. We conclude that the cuticular transpiration barrier is primarily formed by the intracuticular wax but that the epicuticular wax layer may also contribute to it, depending on species-specific cuticle composition. The barrier is associated mainly with VLCFA derivatives and less (if at all) with alicyclic wax constituents. The sealing properties of the epicuticular and intracuticular layers were not correlated with other characteristics, such as the absolute wax amounts and thicknesses of these layers. PMID:26644508

  5. Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2004-12-01

    Full Text Available Segnalazione di tesi di dottorato.Massimo Della Misericordia Divenire comunità. Comuni rurali, poteri signorili, identità sociali in Valtellina e nella montagna lombarda nel tardo medioevo, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Torino, 2003   Mariano Dell’Omo Il monastero di S. Liberatore alla Maiella centro dell’irradiazione di Montecassino nell’Abruzzo medievale e moderno. Contributo alla storia dell’organizzazione patrimoniale e della civiltà monastica cassinese nell’Italia centrale attraverso i documenti di S. Liberatore conservati nell’Archivio di Montecassino. Introduzione storica, paleografica e archivistica. Edizione dei documenti più antichi (†798-1000 e regesti di quelli posteriori (1005-1735, Tesi di dottorato in Storia Ecclesiastica, Facoltà di Storia Ecclesiastica, Pontificia Università Gregoriana di Roma,  2004   Giulia Lorenzoni Conquistare e governare la città. Forme di potere e istituzioni nel primo anno della signoria viscontea a Bologna (ottobre 1350-novembre 1351, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Bologna, 2004   Federica MonteleoneIl viaggio di Carlo Magno in Terra Santa. Un’esperienza di pellegrinaggio nella tradizione europea occidentale, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo   Francesca Pucci Donati Fra teorie mediche e pratica quotidiana: i calendari dietetici dell’Occidente latino altomedievale (secoli IX-XI, Tesi di dottorato di ricerca in Storia medievale (XV ciclo, Università degli studi di Bologna, 2004 Alberto Ricciardi L’Epistolario di Lupo di Ferrières come fonte per la storia degli intellettuali nell’età di Carlo il Calvo, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004   Francesco Paolo Terlizzi I trattati dell'Anonimo Normanno: ricerche di ecclesiologia

  6. Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2005-12-01

    Tra Riforma, vescovo e clientes. Camaldoli e le società locali (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [09/05] Giuseppe Gardoni "Episcopus et potestas". Vescovi e società a Mantova nella prima metà del Duecento, Tesi di dottorato di ricerca in Storia del Cristianesimo e delle Chiese (antichità, medioevo, età moderna, Università degli Studi di Padova, 2005 Nicola Mancassola La gestione delle campagne tra Langobardia e Romània in età carolingia e post carolingia. La struttura delle aziende fondiarie in Emilia e Romagna, Tesi di dottorato in Storia Medievale, Università degli Studi di Bologna, 2005 Gloria Papaccio Storia e archeologia degli opifici idraulici in Val di Pesa. La Badia di Passignano e i suoi mulini (XI-XIV secolo, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Adelaide Ricci La città e il suo ospedale: assetti urbani, dinamiche sociali e organizzazione del sistema caritativo-assistenziale a Cremona nel XV secolo, Tesi di dottorato di ricerca in Storia Medievale, Università degli studi di Torino, 2005 Luca Sant'Ambrogio Il borgo di Treviglio nel secondo Quattrocento: istituzioni e società, Tesi di dottorato di ricerca in Storia Medievale, Università degli Studi di Milano, 2005 Elisabetta Scarton Giovanni Lanfredini. Uomo d'affari e diplomatico nell'Italia del Quattrocento, Tesi di dottorato in Storia della società europea, Università degli Studi di Napoli "Federico II", 2005

  7. Arsenic speciation in Mono Lake, California: Response to seasonal stratification and anoxia

    Science.gov (United States)

    Hollibaugh, James T.; Carini, Steve; Gürleyük, Hakan; Jellison, Robert; Joye, Samantha B.; LeCleir, Gary; Meile, Christof; Vasquez, Lydia; Wallschläger, Dirk

    2005-04-01

    Mono Lake is a closed-basin, alkaline, hypersaline lake located at the western edge of the Great Basin in eastern California. We studied the distribution of arsenic (As) species in the water column of Mono Lake between February and November, 2002. This period captured the seasonal progression from winter mixing, through summer thermal stratification, to autumn overturn. Arsenic speciation was determined by ion chromatography-inductively coupled-plasma-mass spectrometry of samples preserved in the field by flash-freezing in liquid nitrogen. We found that arsenic speciation was dominated (>90%) by arsenate when oxygen was detectable. Once levels fell below 6 μmol/L O 2, arsenic speciation shifted to dominance by reduced species. Arsenate and arsenite co-occurred in a transition zone immediately below the base of the oxycline and low but significant concentrations of arsenate were occasionally detected in sulfidic hypolimnion samples. Thio-arsenic species were the dominant form of As found in sulfidic waters. Maxima of thio-arsenic species with stoichiometries consistent with mono-, di- and trithio-arsenic occurred in succession as sulfide concentration increased. A compound with a stoichiometry consistent with trithio-arsenic was the dominant As species (˜50% of total As) in high sulfide (2 mmol/L) bottom water. Lower concentrations of total As in bottom water relative to surface water suggest precipitation of As/S mineral phases in response to sulfide accumulation during prolonged anoxia.

  8. Di- and Tri- but Not Monomethylation on Histone H3 Lysine 36 Marks Active Transcription of Genes Involved in Flowering Time Regulation and Other Processes in Arabidopsis thaliana▿ †

    OpenAIRE

    Xu, Lin; Zhao, Zhong; Dong, Aiwu; Soubigou-Taconnat, Ludivine; Renou, Jean-Pierre; Steinmetz, Andre; Shen, Wen-Hui

    2007-01-01

    Histone lysines can be mono-, di-, or trimethylated, providing an ample magnitude of epigenetic information for transcription regulation. In fungi, SET2 is the sole methyltransferase responsible for mono-, di-, and trimethylation of H3K36. Here we show that in Arabidopsis thaliana, the degree of H3K36 methylation is regulated by distinct methyltransferases. The SET2 homologs SDG8 and SDG26 each can methylate oligonucleosomes in vitro, and both proteins are localized in the nucleus. While the ...

  9. MRI in hypertrophic mono- and polyneuropathies

    International Nuclear Information System (INIS)

    Different conditions that may lead to enlarged nerves or nerve roots include hereditary motor and sensory neuropathy (HMSN), neurofibromatosis (NF) type 1, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and intraneural perineurioma. Differential diagnosis of hypertrophic mono- and polyradiculopathies remains challenging but is important because of different treatments and prognosis. Magnetic resonance imaging (MRI) can identify the hypertrophic nerve segments and guide a fascicular biopsy. A fascicular biopsy will often be necessary for precise diagnosis

  10. Self-excited mono-ion oscillator

    OpenAIRE

    Dehmelt, Hans; Nagourney, Warren; Sandberg, Jon

    1986-01-01

    We propose self-excitation as a potentially more sensitive technique for studying a mono-ion oscillator of frequency vz ≈ 0.1-100 MHz. This technique also makes only low demands on the harmonicity of the ion oscillation. It should therefore work with inexpensive, easily constructed rf traps. In our analysis, the bound ion between the trap electrodes is represented by an effective circuit resembling that of a piezoelectric quartz crystal. The feedback circuit developed, when operated below sel...

  11. Lezioni di Cosmologia Teorica

    CERN Document Server

    Gasperini, Maurizio

    2012-01-01

    Il libro è basato sulle lezioni attualmente tenute dall'autore presso l’Università di Bari, ed è progettato in modo da rappresentare un testo di riferimento il più possibile moderno, completo e autosufficiente per i corsi semestrale di Cosmologia, Astrofisica o Fisica Astroparticellare che compaiono nel piano di studi della Laurea Magistrale in Fisica e in Astronomia. Contiene gli elementi di base della cosmologia relativistica, del modello cosmologico standard e del suo completamento inflazionario. E' organizzato per servire da traccia ad un corso di cosmologia di stampo teorico, ma cerca di non perdere mai di vista il confronto con i principali risultati osservativi: molta attenzione viene infatti dedicata alla fenomenologia dei fondi cosmici, e in particolare alla  radiazione gravitazionale fossile perché la sua rivelazione, diretta o indiretta, potrebbe dare indicazioni  cruciali sulla scelta del corretto modello per l'Universo primordiale. Non mancano infine alcuni accenni ad argomenti di inter...

  12. Retrodatazioni di viaggio

    OpenAIRE

    Mario Piotti

    2013-01-01

    La letteratura di viaggio, in specie quella sette-ottocentesca, presenta, tra molteplici motivi di interesse, ricchi spunti di indagine anche per la storia della lingua e certamente non è il minore quello relativo agli aspetti lessicali. Nell’articolo non si intende dare una descrizione lessicale completa dei testi odeporici esaminati, ma più limitatamente si presenta una serie cospicua di retrodatazioni e datazioni di parole raccolte in quei testi e quindi ricercate, così allargando lo spet...

  13. Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2010-06-01

    Full Text Available Segnalazione di tesi di dottorato. Andrea Brugnoli Una storia locale: l’organizzazione del territorio veronese nel medioevo: trasformazioni della realtà e schemi notarili (IX-metà XII secolo, Tesi di dottorato di ricerca in Scienze Storiche e Antropologiche (XXII ciclo, Università degli Studi di Verona, 2010   Luca Filangieri Famiglie e gruppi dirigenti a Genova (secoli XII-metà XIII, Tesi di dottorato di ricerca in Storia medievale (XXII ciclo, Università degli Studi di Firenze, 2010   Jakub Kujawi ski Wernakularna kolekcja historiograficzna z rękopisu francuskiego nr 688 z Biblioteki Narodowej w Paryżu. Studium źródłoznawcze (La raccolta dei volgarizzamenti delle opere storiografiche nel manoscritto francese 688 della Biblioteca Nazionale di Parigi, Tesi di dottorato, Università “Adam Mickiewicz”, Facoltà di Storia, Pozna, a.a. 2009/2010   Marta Longhi I signori “de Radicata”. Strategie di affermazione familiare e patrimoniale nel Piemonte dei secoli XII-XIV, Tesi di dottorato di ricerca in Istituzioni, Società, Religioni dal Tardo Antico alla fine del Medioevo (XX ciclo, Università di Torino, 2008

  14. Studio del danneggiamento mediante tomografia in luce del sincrotrone: impatto di un cono d’ombra sulla qualità finale delle ricostruzioni

    Directory of Open Access Journals (Sweden)

    Andrea Bernasconi

    2010-07-01

    Full Text Available Un’accurata osservazione della geometria tridimensionale di cricche e difetti è necessaria per lo studio dei meccanismi alla base del processo di danneggiamento. I metodi convenzionali utilizzati a questo scopo sono distruttivi o non possiedono una sufficiente risoluzione. Le tecniche di imaging che utilizzano la luce di sincrotrone, ed in particolare la microtomografia (micro-CT a raggi X, invece, uniscono i vantaggi di una tecnica non distruttiva ad un’elevata risoluzione spaziale e risultano quindi particolarmente interessanti. Un limite all’applicazione di questa tecnica è costituito dalla propensione della cricca a richiudersi una volta rimosso il carico che ha provocato il danneggiamento, superabile attraverso l’impiego di un dispositivo in grado di esercitare un carico di trazione durante l’acquisizione dei dati. Facendo riferimento al set-up sperimentale della linea SYRMEP di Elettra, il sincrotrone di Trieste, e tralasciando per il momento i vincoli legati a pesi e ingombri, è possibile pensare di inserire tra camera di ionizzazione e CCD una macchina per prove di trazione mono-colonna commerciale, in grado di mantenere aperto il difetto per tutta la durata della tomografia. In questo lavoro viene valutato l’impatto di questo vincolo sulla qualità finale delle ricostruzioni.

  15. Attività di gestione patrimoniale di una società di gestione del risparmio

    OpenAIRE

    Asic, Viktor

    2011-01-01

    Riassunto della tesi di dottorato Titolo: “Attività di gestione patrimoniale di una società di gestione del risparmio” Le società di gestione di risparmio costituiscono il “new vehicle” orientato alla gestione per conto di terzi di portafogli mobiliari. Note con l’acronimo di SGR, le società in questione rappresentano un intermediario finanziario che negli ultimi anni ha assunto notevole importanza grazie ai progressi e alle prospettive offerti dalla nuova normativa che disciplina ...

  16. Laboratorio di Cartografia Archeologica di Roma

    Directory of Open Access Journals (Sweden)

    Redazione Redazione

    2007-03-01

    Full Text Available Il Laboratorio di Cartografia Archeologica nasce per Roma e nei suoi meandri, per così dire, si nasconde. Situato al 28 di via del Monte Testaccio, in quella che la notte diventa la protagonista della vita notturna della Capitale, il Laboratorio passerebbe inosservato se non fosse per la porticina chereca impressa la sua targa. Oltrepassata la soglia, però, quelloche si incontra è un gigantesco mondo di materiale cartografico e di informazioni dedicate alla vasto patrimonio archeologico (ma non solo che caratterizza Roma.

  17. Study on Kinetics of Natural Rubber Vulcanization by S/La(DiPDP)3

    Institute of Scientific and Technical Information of China (English)

    Lin Xinhua; Liu Qingting; Chen Zhaohui; Wang Dizhen

    2007-01-01

    Kinetics of natural rubber (NR) vulcanization by lanthanum O, O'-diisopropyldithiophosphate [La(DiPDP)3] was studied. La(DiPDP)3 had remarkable accelerating effect on the vulcanization of NR. The rate constant k6 of the reaction that turned polysulphidic cross-links into the modified main chain was higher than that of desulfuration reaction of polysulfidic cross-links (k3). The activation energies (Ea2, Ea3, and Ea6) of the formation, desulfuration, and decomposition of polysulfidic cross-links were 87.57, 102.34, and 95.01 kJ·mol-1, respectively. Activation energy (Ea5) of the reaction that turned the cross-link precursors into the modified main chain was 82.67 kJ·mol-1. It could be concluded that the proportion of polysulphidic cross-links was higher than mono- and di- sulphidic cross-links during induction and curing periods, mono- and di- sulphidic cross-links increased as curing temperature rose. In the temperature range of 140~160 ℃, the amounts of polysulphidic cross-links were similar. However, over 160 ℃, mono- and di- sulphidic cross-links increased rapidly. Moreover, cross-link density of the vulcanizates was determined from the equilibrium-swelling data. A chemical probe detected the concentration of polysulphidic cross-links of vulcanizates. The change trend of the results predicated from equation corresponded to that of the experimental results.

  18. Taratura di un 'apparecchiatura per misura di piccole percentuali di uranio in soluzione acida di acqua distillata

    Directory of Open Access Journals (Sweden)

    d. Diana

    1965-06-01

    Full Text Available Si descrive una tecnica elio permette di misurare ilnumero di atomi di Uranio di una soluzione, con un errore non superioreal 10%.Il sistema consiste in un tubo di Geiger (Philips 18503 sistemato inun contenitore di vetro nel quale viene diluita una certa quantità di peso dinitrato di Uranile, misurato con una precisione migliore dell'1%. Al variaredella diluizione si registra il numero di particelle che il Geiger conta, e quindisi riporta in grafico. Da questi per diverse quantità di sale sciolto si determinala retta di taratura.

  19. Biological in vitro and in vivo studies of a series of new asymmetrical cationic [99mTc(N)(DTC-Ln)(PNP)]+ complex (DTC-Ln = alicyclic dithiocarbamate and PNP = diphosphinoamine).

    Science.gov (United States)

    Bolzati, Cristina; Cavazza-Ceccato, Mario; Agostini, Stefania; Refosco, Fiorenzo; Yamamichi, Yoshihiro; Tokunaga, Shinji; Carta, Davide; Salvarese, Nicola; Bernardini, Daniele; Bandoli, Giuliano

    2010-05-19

    (99m)Tc(N)-DBODC5 is a cationic mixed compound under clinical investigation as potential myocardial imaging agent. In spite of this, analogously to the other cationic (99m)Tc-agents, presents a relatively low first-pass extraction. Thus, modification of (99m)Tc(N)-DBODC(5) direct to increase its first-pass extraction keeping unaltered the favorable imaging properties would be desirable. This work describes the synthesis and biological evaluation of a series of novel cationic (99m)Tc-nitrido complexes, of general formula [(99m)TcN(DTC-Ln)(PNP)](+) (DTC-Ln= alicyclic dithiocarbamates; PNP = diphosphinoamine), as potential radiotracers for myocardial perfusion imaging. The synthesis of cationic (99m)Tc-(N)-complexes were accomplished in two steps. Biodistribution studies were performed in rats and compared with the distribution profiles of (99m)Tc(N)-DBODC5 and (99m)Tc-Sestamibi. The metabolisms of the most promising compounds were evaluated by HPLC methods. Biological studies revealed that most of the complexes have a high initial and persistent heart uptake with rapid clearance from nontarget tissues. Among tested compounds, 2 and 12 showed improved heart uptake with respect to the gold standard (99m)Tc-complexes with favorable heart-to-liver and slightly lower heart-to-lung ratios. Chromatographic profiles of (99m)Tc(N)-radioactivity extracted from tissues and fluids were coincident with the native compound evidencing remarkable in vivo stability of these agents. This study shows that the incorporation of alicyclic dithiocarbamate in the [(99m)Tc(N)(PNP)](+) building block yields to a significant increase of the heart uptake at early injection point suggesting that the first-pass extraction fraction of these novel complexes may be increased with respect to the other cationic (99m)Tc-agents keeping almost unaltered the favorable target/nontarget ratios. PMID:20402465

  20. On mono-W signatures in spin-1 simplified models

    Science.gov (United States)

    Haisch, Ulrich; Kahlhoefer, Felix; Tait, Tim M. P.

    2016-09-01

    The potential sensitivity to isospin-breaking effects makes LHC searches for mono-W signatures promising probes of the coupling structure between the Standard Model and dark matter. It has been shown, however, that the strong sensitivity of the mono-W channel to the relative magnitude and sign of the up-type and down-type quark couplings to dark matter is an artifact of unitarity violation. We provide three different solutions to this mono-W problem in the context of spin-1 simplified models and briefly discuss the impact that our findings have on the prospects of mono-W searches at future LHC runs.

  1. Testimonianze di vittime degli anni di piombo

    DEFF Research Database (Denmark)

    Cecchini, Leonardo

    Testimonianze di vittime degli anni di piombo In un articolo pubblicato nel 2008 sulla webzine Nazione indiana Christian Raimo criticava quello che poi Giovanni De Luna qualche anno dopo nel suo libro La Repubblica del dolore (2011) ha chiamato “paradigma vittimario”; cioè la presenza predominante...

  2. Nella stanza di Asperger...

    Directory of Open Access Journals (Sweden)

    Alessandra Gilardini

    2011-09-01

    Full Text Available Gli studi sulla struttura del cervello di persone con Asperger avrebbero mostrato una diversa conformazione del lobo parietale (deputato all’elaborazione di soluzioni ai problemi, del lobo temporale mediale (sede della memoria a lungo termine e del cervelletto (coordinatore del movimento corporeo. Queste differenze possono spiegare le capacità a volte geniali di questi bambini e di questi adulti, oltre alla caratteristica ritualità nei gesti che li accompagna nel quotidiano.

  3. Obbligo di covendita

    OpenAIRE

    Ferrante, Manuel

    2011-01-01

    Il presente lavoro si pone come proposito l’analisi della covendita, fenomeno che non trova alcun espresso riferimento normativo all’interno della legislazione italiana, ma che è entrato a far parte del nostro ordinamento attraverso il recepimento di alcuni strumenti contrattuali nati ed operanti in ordinamenti giuridici stranieri, precisamente nei sistemi di Common Law: le cd. clausole di tag-along (letteralmente “attaccare insieme”) e di drag-along (letteralmente “trascinare insieme”). L...

  4. Problemi di Fisica

    CERN Document Server

    Fazio, Michelangelo

    2008-01-01

    L’introduzione delle lauree triennali ha in molti casi costretto i docenti a ridurre drasticamente il numero di ore di insegnamento e quindi l’estensione dei programmi dei corsi di Fisica. In questo volumetto l'autore si è proposto di esporre sinteticamente ma con il massimo rigore possibile il corso di Fisica Generale I evitando le dimostrazioni delle leggi fisiche, ma dando la priorità alle applicazioni di tali leggi e allo svolgimento di esercizi che in genere viene trascurato in molti corsi. Ha cercato pertanto di presentare i fenomeni fisici sottolineando, dove possibile, la loro presenza nella vita quotidiana e le loro più semplici e immediate applicazioni, consentendo in tal modo agli studenti di vedere la Fisica non più come una interminabile serie di formule ma come un nuovo modo di interpretare e di capire i fenomeni naturali inanimati (del resto non dobbiamo dimenticare che il termine greco da cui deriva il suo nome è fisis, fisis, ovvero natura). Il contenuto è completo, comprendendo anc...

  5. Ottimizzazione di portafogli di ETF nell' approccio di consulenza finanziaria indipendente

    OpenAIRE

    Zorzi, Gianni

    2010-01-01

    Quella del consulente finanziario indipendente (Capitolo 1) è una figura professionale di elevato standing sviluppatasi a partire dagli anni ‘70 negli Stati Uniti, paese in cui l’attività è correntemente svolta da decine di migliaia di persone fisiche, iscritte ad associazioni di categoria, provviste di certificazioni anche di notevole spessore, come quella del Certified Financial Planner (CFP). Tale modello di consulenza in assenza di conflitto d’interessi è detto anche “fee-only” in virt...

  6. Analisi di un campione significativo di Learning Objects.

    Directory of Open Access Journals (Sweden)

    Luigi Guerra

    2006-01-01

    Full Text Available Il lavoro analizza sul piano pedagogico e didattico il concetto di Learning Object (LO a partire dalla rilevazione diretta dei modelli formativi sottostanti, in forma esplicita o implicita, un campione significativo di Learning Objects identificato all’interno di rilevanti esperienze di e-learning universitarie e non universitarie prodotte in diverse nazioni, allo scopo di giungere alla messa a punto di una modellistica problematica di tipo didattico dei Learning Objects, funzionale alla costruzione di algoritmi differenziati di progettazione, realizzazione, erogazione e valutazione di LO, anche nella prospettiva dei Learning Artifacts.

  7. Il catalogo di donne di Venzone (sec. XIV):

    OpenAIRE

    Federico Vicario

    2009-01-01

    Nell’articolo si presenta l’edizione di un documento friulano tardomedievale, il catalogo di donne di venzone (sec. Xiv), un documento conservato presso la Biblioteca Civica di Udine «V. Joppi». All’edizione, diplomatica, segue un commento linguistico, in particolare sull’onomastica personale, sul lessico comune e sulla toponomastica; l’esame del testo consente di isolare numerosi elementi di interesse, nomi femminili e maschili, ma anche nomi di mestiere e funzione, che costituiscono gli ant...

  8. Dispositivi elettroluminescenti organici: tecnologie di fabbricazione e metodologie di caratterizzazione

    OpenAIRE

    Maglione, Maria Grazia

    2006-01-01

    [ITALIANO] L’attività di ricerca si è concentrata sulla realizzazione e caratterizzazione di dispositivi elettroluminescenti organici (OLED) e quindi sull’ottimizzazione dei processi di deposizione e caratterizzazione di film sottili di materiali organici e metallici di cui sono composti. Le maggiori industrie elettroniche del mondo (Samsung, Sony, Seiko-Epson, KODAK, etc.) prevedono che in futuro i display OLED contenderanno quote di mercato sempre più consistenti agli LCD (Liquid Crystal...

  9. Che genere di diritto?

    Directory of Open Access Journals (Sweden)

    Delia La Rocca

    2014-04-01

    Full Text Available Il recente decreto legge sul femminicidio nasce in un clima, soprattutto mediatico, nel quale la violenza sulle donne viene letta come “emergenza”. Questa chiave di lettura del fenomeno presenta alcuni rischi: in primo luogo, quello di riproporre un modello di intervento pubblico centrato soprattutto sull’approccio repressivo. Il decreto assegna, infatti, una valenza residuale ad una strategia di sostegno delle azioni di prevenzione e di assistenza delle vittime di violenza, al momento rinviate ad un “Piano d'azione straordinario” per il quale non viene previsto alcun finanziamento. E’ tempo di uscire dalla logica emergenziale: la questione della violenza di genere non è solo problema di ordine pubblico. E’ un fenomeno che colpisce al cuore la riscrittura delle regole sulla convivenza tra i generi avviata nel secolo scorso. Ciò che serve è un nuovo momento di elaborazione delle teorie e delle prassi delle donne sul ruolo del sistema giuridico e sulle forme più adeguate per garantire la libertà femminile.

  10. Densità di energia di deformazione locale e resistenza a fatica di giunti saldati di geometria complessa

    Directory of Open Access Journals (Sweden)

    P. Lazzarin

    2008-01-01

    Full Text Available Un recente criterio basato sul valore medio della densità di energia di deformazione (SED inun volume di controllo è applicato a diverse serie di dati sperimentali tratti dalla letteratura, relativi a giuntisaldati di geometria complessa realizzati in acciaio. Il volume di controllo è rappresentato da un settore circolare di raggio pari a 0.28 mm, centrato sul piede o sulla radice dei cordoni di saldatura. Entrambe le regioni sono modellate come intagli V non raccordati con differenti angoli di apertura. La densità di energia di deformazione viene valutata direttamente da modelli agli elementi finiti tridimensionali. I dati sperimentali, riconvertiti in termini energetici, si posizionano all’interno di una banda di dispersionerecentemente proposta in letteratura. La banda sintetizzava più di 650 dati sperimentali relativi a giunti saldati con cordone d’angolo, con rotture innescate indifferentemente al piede o alla radice dei cordonidi saldatura.

  11. Viscoelasticity of mono- and polydisperse inverse ferrofluids.

    Science.gov (United States)

    Saldivar-Guerrero, Ruben; Richter, Reinhard; Rehberg, Ingo; Aksel, Nuri; Heymann, Lutz; Rodriguez-Fernández, Oliverio S

    2006-08-28

    We report on measurements of a magnetorheological model fluid created by dispersing nonmagnetic microparticles of polystyrene in a commercial ferrofluid. The linear viscoelastic properties as a function of magnetic field strength, particle size, and particle size distribution are studied by oscillatory measurements. We compare the results with a magnetostatic theory proposed by De Gans et al. [Phys. Rev. E 60, 4518 (1999)] for the case of gap spanning chains of particles. We observe these chain structures via a long distance microscope. For monodisperse particles we find good agreement of the measured storage modulus with theory, even for an extended range, where the linear magnetization law is no longer strictly valid. Moreover we compare for the first time results for mono- and polydisperse particles. For the latter, we observe an enhanced storage modulus in the linear regime of the magnetization. PMID:16965057

  12. Mono Lake's Radiocarbon Budget: An unsolved enigma

    Science.gov (United States)

    Broecker, Wallace; Stine, Scott

    Mono Lake occupies a semiarid basin just east of the central Sierra Nevada in California. During the past 4 decades, diversion of the lake's tributary streams by the Los Angeles Department of Water and Power (LADWP) has caused the lake to shrink dramatically. This shrinkage has concentrated the salts that occur naturally in the lake, forcing the salinity to rise toward levels that will cause the extinction of the resident brine shrimp and brine flies that provide food for many hundreds of thousands of migratory waterfowl. The lake is now the focus of a pitched battle between conservationists who want to curtail diversions before serious ecological consequences occur and the LADWP, whose responsibility is to supply the city with water.

  13. Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

    Directory of Open Access Journals (Sweden)

    Stefano D'Errico

    2014-07-01

    Full Text Available The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyladenosine or a 1,6-di(adenosin-N6-yl-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamineplatinum(II, is reported. The chemistry exploits the high affinity of the charged platinum centres towards the N7 position of the adenosine base system and a primary amine of an alkyl chain installed on the C6 position of the purine. The cytotoxic behaviour of the synthesized complexes has been studied in A549 adenocarcinomic human alveolar basal epithelial and MCF7 human breast adenocarcinomic cancer cell lines, in order to investigate their effects on cell viability and proliferation.

  14. Mono(2-ethylhexyl)phthalate accumulation disturbs energy metabolism of fat cells.

    Science.gov (United States)

    Chiang, Huai-Chih; Kuo, Ya-Ting; Shen, Chih-Che; Lin, Yi-Hua; Wang, Shu-Li; Tsou, Tsui-Chun

    2016-03-01

    Phthalates are lipophilic and tend to accumulate in adipose tissue, an important regulator of energy balance and glucose homeostasis. The study aimed to determine whether cellular phthalate accumulation influenced fat cell energy metabolism. Following a 3-day treatment with adipogenesis-inducing medium and a 2-day treatment with adipogenesis-maintaining medium, 3T3-L1 cells differentiated into adipocytes in the presence of a phthalate at a clinically relevant concentration (30-300 μM) for another 6 days. Two phthalates, di(2-ethylhexyl)phthalate and di-n-butylphthalate, and their metabolites, mono(2-ethylhexyl)phthalate (MEHP) and mono-n-butylphthalate, were used here. The phthalate treatments caused no marked effect on cytotoxicity and adipogenesis. Only the MEHP-treated adipocytes were found having smaller lipid droplets; MEHP accumulated in cells in a dose- and time-dependent manner. The MEHP-treated adipocytes exhibited significant increases in lipolysis and glucose uptake; quantitative real-time polymerase chain reaction (qPCR) analysis revealed correlated changes in expression of marker genes involved in adipogenesis, lipid metabolism, and glucose uptake. Analysis of oxygen consumption rate (a mitochondrial respiration indicator) and extracellular acidification rate (a glycolysis indicator) indicated a higher energy metabolism in the adipocytes. qPCR analysis of critical genes involved in mitochondrial biogenesis and/or energy metabolism showed that expression of peroxisome proliferator-activated receptor γ coactivator-1α, sirtuin 3, and protein kinase A were significantly enhanced in the MEHP-treated adipocytes. In vitro evidence of MEHP impacts on lipolysis, glucose uptake/glycolysis, and mitochondrial respiration/biogenesis demonstrates that MEHP accumulation disturbs energy metabolism of fat cells. PMID:25543134

  15. Studio di approfondimento sullo stato di salute nei Comuni dell'Alta Val di Cecina

    OpenAIRE

    Romanelli, Anna Maria; Bartolacci, Simone; Capocchi, Rachele; Mariani, Silvia; Minichilli, Fabrizio; Protti, Maria Angela; Salvadori, Patrizia; Tacconi, Giorgia; Vigotti, Maria Angela; Bianchi, Fabrizio

    2009-01-01

    Uno studio preliminare sull'Alta Val di Cecina, AVC, (Pisa) aveva evidenziato che tra le cause di morte, 1970-2004, alcune avevano un impatto pi? elevato o in controtendenza rispetto alla media regionale toscana; l'area presenta un sottosuolo geologicamente attivo, industrie chimiche, di produzione di energia, estrattive, documentate contaminazioni di acqua e suolo da metalli pesanti. Si segnalano eccessi di mortalit? e/o di ospedalizzazione per alcune patologie per le quali in letteratura ri...

  16. Profili critici di tassazione dei redditi di capitale e dei fondi di investimento

    OpenAIRE

    Adriano Benazzi; Pier Luigi Marchini

    2010-01-01

    La tassazione del risparmio gestito e, più in generale, dei redditi di capitale, rappresenta da sempre una delle questioni più rilevanti, critiche e complesse. Ciò sia per le implicazioni economico-scientifiche connesse al sistema di tassazione dei cosiddetti "redditi finanziari", sia per l’eterogeneità e mutevolezza delle forme di impiego del capitale e di "generazione" dei suoi frutti economici, sia in conseguenza delle possibili problematiche di asimmetria di trattamento e di potenziale in...

  17. Identificazione e trasferimento di QTL coinvolti nell’accumulo di antiossidanti nel frutto di pomodoro

    OpenAIRE

    Lombardi, Nadia

    2011-01-01

    L’obiettivo del progetto ha riguardato la combinazione di QTL coinvolti nell’incremento del contenuto in antiossidanti nel frutto di pomodoro. A tale scopo sono state utilizzate le linee di introgressione (IL) di pomodoro. Tali IL sono particolarmente utili per la dissezione di caratteri complessi e consentono l’individuazione ed il mappaggio di QTL di interesse su specifici cromosomi. Il trasferimento dei QTL e la loro combinazione in nuovi genotipi è stato perseguito eseguendo incroci tra l...

  18. Introduzione alle teorie di gauge

    CERN Document Server

    Cabibbo, Nicola; Benhar, Omar

    2016-01-01

    "Introduzione alle Teorie di Gauge" completa la serie di tre volumi basati sulle lezioni dei corsi di Meccanica Quantistica Relativistica, Interazioni Elettrodeboli e Teorie di Gauge, impartite dagli autori agli studenti delle Lauree Magistrali in Fisica e Astronomia & Astrofisica dell'Universita "La Sapienza" di Roma, nell'arco di qualche decennio. L'obiettivo principale del volume è di introdurre i concetti di base della rinormalizzazione nella teoria quantistica dei campi e i fondamenti delle moderne teorie di Gauge. Anche se collegato ai volumi precedenti, il libro si presta ad una lettura indipendente, che presume solo conoscenze generali di relativita speciale, della seconda quantizzazione e della fenomenologia delle interazioni elettrodeboli. Lo strumento di base è l'integrale sui cammini di Feynman, introdotto nei capitoli iniziali e sistematicamente impiegato nel seguito. L'esposizione segue un percorso pedagogico, che parte dal caso semplice dell'ampiezza di transizione in meccanica quantistic...

  19. Appunti di Domotica

    OpenAIRE

    Bianchi Bandinelli, Rolando; Miori, Vittorio

    2008-01-01

    Le presenti dispense erano state scritte per facilitare lo studente a seguire lo svolgimento del corso di domotica. Poich? attualmente l'argomento interessa anche fasce pi? larghe di lettori, se ne ? curata una versione pi? adatta ad un pubblico pi? vasto. L'argomento trattato ? "giovane" e in forte evoluzione e certe informazioni potrebbero diventare obsolete nel giro di poco tempo. ? quindi possibile che alcune affermazioni particolari non corrispondano alla realt? del momento in cui vengon...

  20. Programmazione del Network di 'Virologia Ambientale': Stato di avanzamento

    OpenAIRE

    Carlesi, Carlo

    2004-01-01

    Presentazione 'Power Point' dell'intervento all'incontro di lavoro 'VIRAMB II incontro del Network di Virologia Ambientale', presso l'Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana. Nell'intervento si presenta lo stato di avanzamento dei lavori riguardo la realizzazione dell'infrastruttura telematica del 'Network di Virologia Ambientale' promosso dal 'Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia' dell'Universit? di Pisa.

  1. MONO FOR CROSS-PLATFORM CONTROL SYSTEM ENVIRONMENT

    International Nuclear Information System (INIS)

    Mono is an independent implementation of the .NET Framework by Novell that runs on multiple operating systems (including Windows, Linux and Macintosh) and allows any .NET compatible application to run unmodified. For instance Mono can run programs with graphical user interfaces (GUI) developed with the C(numbersign) language on Windows with Visual Studio (a full port of WinForm for Mono is in progress). We present the results of tests we performed to evaluate the portability of our controls system .NET applications from MS Windows to Linux

  2. MONO FOR CROSS-PLATFORM CONTROL SYSTEM ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, Hiroshi; Timossi, Chris

    2006-10-19

    Mono is an independent implementation of the .NET Frameworkby Novell that runs on multiple operating systems (including Windows,Linux and Macintosh) and allows any .NET compatible application to rununmodified. For instance Mono can run programs with graphical userinterfaces (GUI) developed with the C# language on Windows with VisualStudio (a full port of WinForm for Mono is in progress). We present theresults of tests we performed to evaluate the portability of our controlssystem .NET applications from MS Windows to Linux.

  3. Professional Android Programming with Mono for Android and NETC#

    CERN Document Server

    McClure, Wallace B; Croft, John J; Dick, Jonathan; Hardy, Chris

    2012-01-01

    A one-of-a-kind book on Android application development with Mono for Android The wait is over! For the millions of .NET/C# developers who have been eagerly awaiting the book that will guide them through the white-hot field of Android application programming, this is the book. As the first guide to focus on Mono for Android, this must-have resource dives into writing applications against Mono with C# and compiling executables that run on the Android family of devices. Putting the proven Wrox Professional format into practice, the authors provide you with the knowledge you need to become a succ

  4. Dai bisogni di salute al consumo di risorse sanitarie in provincia di Bergamo: profilo degli indicatori di bisogno, domanda, offerta

    Directory of Open Access Journals (Sweden)

    A. Zucchi

    2003-05-01

    Full Text Available

    Introduzione: la complessità interpretativa dei dati relativi ad alcuni fenomeni sanitari a livello territoriale impone la necessità di uno strumento semplice di lettura “epidemiologica”; tale lettura si fonda sull’utilizzo di una serie di “indicatori”, fondamenta di un processo dinamico di monitoraggio temporale e spaziale in grado di descrivere sinteticamente fenomeni di per sé complessi, al fine di fornire al decisore un supporto sintetico ma scientificamente solido.

    Obiettivi: istituzione di un sistema di monitoraggio sanitario community-based; definizione di indicatori sanitari comparabili tramite un esame critico dei dati esistenti; sviluppo di metodologie per la raccolta e la validazione dei dati; supporto alla creazione di un sistema efficace e affidabile di trasferimento e scambio dei dati e degli indicatori stessi con uso spinto della tecnologia telematica; elaborazione di metodi e di strumenti necessari alla produzione di analisi e relazioni.

    Materiali e metodi: gli indicatori analizzati fanno riferimento
    all’elenco definito dal decreto ministeriale n. 27 del 12 dicembre 2001 “sistema di garanzie per il monitoraggio dell’assistenza sanitaria”. A questo elenco ne sono stati aggiunti altri, per un totale di 127, divisi in grandi capitoli tematici: assistenza sanitaria, assistenza distrettuale, assistenza ospedaliera, indicatori stato di salute, consumo di risorse sanitarie (cui è stato dato particolare enfasi, indicatori di domanda/accessibilità. Per definire infine un
    profilo di sintesi di questi grandi capitoli e delle relative
    eterogeneità territoriali si è successivamente applicata la tecnica statistica dello “z-score”.
    Risultati: le differenze emerse a livello distrettuale hanno permesso di disegnare una ‘mappa’ degli indicatori sanitari in provincia di Bergamo.

    Conclusioni:i risultati di

  5. Il catalogo di donne di venzone (sec. XIV

    Directory of Open Access Journals (Sweden)

    Federico Vicario

    2009-05-01

    Full Text Available Nell’articolo si presenta l’edizione di un documento friulano tardomedievale, il catalogo di donne di venzone (sec. Xiv, un documento conservato presso la Biblioteca Civica di Udine «V. Joppi». All’edizione, diplomatica, segue un commento linguistico, in particolare sull’onomastica personale, sul lessico comune e sulla toponomastica; l’esame del testo consente di isolare numerosi elementi di interesse, nomi femminili e maschili, ma anche nomi di mestiere e funzione, che costituiscono gli antecedenti di numerosi cognomi moderni. Si conferma l’importanza fondamentale dello studio sistematico delle carte friulane di uso pratico, come quelle qui presentate, operazione preliminare e indispensabile al fine di avviare, in seguito, opere di lessicografia di ampia prospettiva, in primis la redazione di un dizionario storico comprensivo delle forme antiche. Sembra quest’ultimo un obiettivo ormai alla portata, potendo contare sui progressi che la disciplina ha compiuto negli ultimi anni, con lo svolgimento di un vasto progetto di ricognizione dei fondi archivistici di tutto il Friuli storico promosso dalla Società Filologica Friulana e dal Ministero per i Beni culturali (documenti antichi dagli archivi friulani. Ai positivi risultati ottenuti con lo svolgimento di questo progetto si aggiungono le numerose edizioni realizzate su fondi manoscritti conservati in alcuni degli enti conservatori più importanti della regione, a partire ancora dai materiali antichi depositati presso la Biblioteca Civica di Udine.

  6. Self-excited mono-ion oscillator.

    Science.gov (United States)

    Dehmelt, H; Nagourney, W; Sandberg, J

    1986-08-01

    We propose self-excitation as a potentially more sensitive technique for studying a mono-ion oscillator of frequency v(z) approximately 0.1-100 MHz. This technique also makes only low demands on the harmonicity of the ion oscillation. It should therefore work with inexpensive, easily constructed rf traps. In our analysis, the bound ion between the trap electrodes is represented by an effective circuit resembling that of a piezoelectric quartz crystal. The feedback circuit developed, when operated below self-excitation threshold, may also make efficient electronic cooling of the ion possible, particularly in conjunction with a heterodyne feedback scheme. In the super-regenerative mode, the apparatus might function as a powerful atomic amplifier of the ion oscillation for an energy as low as a fraction of hv(z). These techniques may prove especially useful in conjunction with attempts to synthesize in an rf trap a loosely bound anti-hydrogen atom from a positron and antiproton. PMID:16593742

  7. Small scale synthesis of nucleoside mono-, di-, and triphosphates on Controlled Pore Glass (CPG)

    Czech Academy of Sciences Publication Activity Database

    Liboska, Radek; Zborníková, Eva; Rosenberg, Ivan

    Lyon : Université de Lyon, 2010, s. 335-335. [International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. IRT 2010. Lyon (FR), 29.08.2010-03.09.2010] R&D Projects: GA AV ČR KAN200520801; GA MŠk(CZ) LC06061 Institutional research plan: CEZ:AV0Z40550506 Keywords : triphosphate synthesis * nucleoside triphosphate * solid phase synthesis Subject RIV: CC - Organic Chemistry http://irt2010.univ-lyon1.fr

  8. Structure-activity relationship of aliphatic mono- and di-N-oxides: their radical scavenging abilities

    Czech Academy of Sciences Publication Activity Database

    Krasowska, A.; Murzyn, A.; Piasecki, A.; Sigler, Karel

    Poland: Polish Biochemical Society, 2006, s. 130-130. [Meeting of the Polish Biochemical Society /41./. Bialystok (PL), 12.09.2006-15.09.2006] R&D Projects: GA MŠk 1M0570 Grant ostatní: Polsko(PL) 3T09B 075 27 Institutional research plan: CEZ:AV0Z50200510 Keywords : plasma membrane * peroxyl radicals Subject RIV: EE - Microbiology, Virology

  9. The Soret effect of mono-, di- and tri-glycols in ethanol

    OpenAIRE

    Klein, M.; Wiegand, S.

    2011-01-01

    We employed thermal diffusion forced Rayleigh scattering (TDFRS) to investigate the chain length dependence of the thermal diffusion behavior of short glycols in ethanol. We studied three glycols, monoethylenglycol (MEG), diethylenglycol (DEG) and triethylenglycol (TEG), in an ethanol solution. In contrast to the polymer polyethylenglycol, the shorter glycols used within the framework of this study are completely soluble in ethanol, at least for low molar fractions. In order to guarantee a go...

  10. Influence of structure on electrochemical reduction of isomeric mono- and di-, nitro- or nitrosocalix[4]arenes

    Czech Academy of Sciences Publication Activity Database

    Liška, Alan; Flídrová, K.; Lhoták, P.; Ludvík, Jiří

    2015-01-01

    Roč. 146, č. 5 (2015), s. 857-862. ISSN 0026-9247 R&D Projects: GA ČR GA13-21704S Institutional support: RVO:61388955 Keywords : Electrochemical reduction * Nitrocalix[4]arenes * Nitrosocalix[4]arenes Subject RIV: CG - Electrochemistry Impact factor: 1.222, year: 2014

  11. Resistivity Imaging of the Mono-Inyo Volcanic Chain, Mono Basin, California Using the Audiomagnetotelluric Method

    Science.gov (United States)

    McPhee, D. K.; Ponce, D. A.; Pera McDonell, A.; Chuchel, B. A.

    2011-12-01

    Audiomagnetotelluric (AMT) models of data collected in Mono Basin, California show significant structure within the upper kilometer of the basin and image a shallow resistor that may be related to a shallow basement feature. The Mono-Inyo volcanic chain is a 25-km long, north-south trending series of domes and craters extending southward from Mono Lake and into the western part of the Long Valley Caldera. Gravity and magnetic modeling in the region, prompted by a volcano hazards study, show a basement high associated with an apparent circular magnetic anomaly. AMT data are used to further investigate this potential field anomaly and image the geoelectric structure within the volcanic rocks in Mono Basin. We collected AMT data along two profiles in Pumice Valley and along the western margin of the domes. Profile A runs approximately east-west, perpendicular to the regional geologic strike, and extends 2.5 km from the southern edge of North Coulee into the basin. Profile B is a north-south trending 6 km-long profile within the basin and was located several hundred meters away from the volcanic chain. Both profiles perpendicularly intersect the circular magnetic feature. We computed both one-dimensional and two-dimensional (2D) inverse models along each profile. 2D models were computed using the conjugate gradient, finite-difference method of Rodi and Mackie (2001) and a 100 ohm-m half-space, starting model. One-dimensional model sensitivity and various 2D starting models indicate a depth of investigation of about 1 km. Preliminary models show a relatively conductive (~20 ohm-m) volcanic basin fill likely associated with the Bishop Tuff, a voluminous pyroclastic flow, whose eruption resulted in formation of the Long Valley caldera 760 Ka ago. Resistivity variations within the basin fill may be related to the porosity or amount of fracturing of individual flows. A resistive (> 200 ohm-m) feature at roughly 600-800 m depth coincides with the magnetic high and relative

  12. Reti di città, mobilità e ambiente: il Preliminare di PTCP di Avellino

    Directory of Open Access Journals (Sweden)

    Carmela Gargiulo

    2010-02-01

    Full Text Available  L’articolo propone la lettura dei contenuti del Preliminare del PTCP di Avellino, un piano per molti aspetti innovativo, soprattutto per aver coniugato pianificazione di area vasta di tipo tradizionale e logica “strategica”. In particolare, l’articolo descrive idee guida, contenuti e strategie del piano orientate, prevalentemente, a stimolare lo sviluppo sostenibile di un’area in ritardo di sviluppo come la provincia irpina, attraverso la salvaguardia e valorizzazione delle risorse naturali e storico-culturali, la costruzione di reti di medie e piccole città e reti di mobilità alle diverse scale, da quella urbana a quella internazionale, e interventi sul sistema della mobilità. Nel 2004, ormai più di cinque anni fa, è stato adottato, a maggioranza assoluta (solo due gli astenuti, il Preliminare di Piano Territoriale di Coordinamento della Provincia di Avellino, dopo un lavoro di oltre due anni che ha visto impegnati gli uffici provinciali con due dipartimenti universitari. Il lavoro, che va ben oltre il significato e la valenza di un preliminare e che coniuga due pratiche di piano diverse (quella tradizionale e quella strategica ruota attorno a tre idee di fondo, tra loro strettamente interrelate, che costituiscono i criteri guida che finora ha inteso seguire la provincia di Avellino nell’attività di governo delle trasformazioni. Tali idee, quindi, costituiscono le fondamenta su cui è stato costruito il Preliminare e sono la griglia di specificazione delle strategie e degli obiettivi di piano. Esse sono alla base delle scelte elaborate per lo sviluppo compatibile del territorio, e sono riferibili alle azioni operative di trasformazione del territorio che gli Enti locali, cui è demandato tale compito, nel prossimo futuro dovranno affrontare. Le tre idee forza del Preliminare, descritte nel seguito, sono riferibili ai sistemi di risorse principali della provincia di Avellino, oggetto di una indagine analitico

  13. Sperimentazione in osservatorio di un nuovo magnetometro a vapore di potassio pompato da laser a diodo

    OpenAIRE

    Beverini, N.; UNIPI; Faggioni, O.; Istituto Geofisica Marina - CUNISPE; Alzetta, E.; UNIPI; Maccioni, E.; UNIPI; Carmisciano, C.; Istituto Geofisica Marina - CUNISPE

    1998-01-01

    Nel Dipartimento di Fisica dell'Università di Pisa e' stato sviluppato un nuovo tipo di magnetometro a vapore di alcalino, basato sulla misura della frequenza di risonanza Zeeman dell'atomo di potassio .....

  14. Greater Sage-grouse Telemetry - Mono Co. [ds68

    Data.gov (United States)

    California Department of Resources — Combined telemetry locations for sage grouse in Mono County which were fitted with radio-transmitters for the USGS Greater sage-grouse project. Contains spatial and...

  15. Elaborazione didattica di Learning Objects.

    Directory of Open Access Journals (Sweden)

    Luigi Guerra

    2006-01-01

    Full Text Available L’idea di un modello didattico problematico per la realizzazione di Learning Objects riprende i temi del problematicismo pedagogico e si impegna a definire un’ipotesi formativa complessa capace di valorizzare la possibile positiva compresenza integrata di strategie didattiche diverse (finanche antitetiche ma componibili in una logica appunto di matrice problematicista. Il punto di partenza del modello proposto è rappresentato dalla opportunità di definire tre tipologie fondamentali di Learning Objects, rispettivamente centrati sull’oggetto, sul processo e sul soggetto dell’apprendimento.

  16. Elementi di fisica teorica

    CERN Document Server

    Cini, Michele

    2006-01-01

    Le idee e le tecniche della Fisica Teorica del XX secolo (meccanica analitica, meccanica statistica, relatività e meccanica quantistica non relativistica) non sono più appannaggio esclusivo dei fisici. Ormai, specialmente con la recente introduzione di nuovi corsi di laurea, le conoscenze di base rientrano nel bagaglio culturale comune ai laureati in materie scientifiche e tecnologiche affini alla Fisica e alle sue applicazioni. Un laureato in queste materie non può non conoscere l’equazione E=mc2 e la media di Gibbs; inoltre deve avere i concetti e i metodi fondamentali della meccanica quantistica che ha cambiato la concezione del mondo ed è alla base della rivoluzione tecnologica in corso. Eppure quelle idee rimangono distanti dal comune modo di pensare e richiedono molto studio e un insegnamento ben mirato. La trattazione in questo libro, è meno formale rispetto ai tradizionali corsi di Istituzioni di Fisica Teorica. Lo scopo è comunque quello di raggiungere una reale comprensione dei concetti fisi...

  17. Realizzazione digitale di algoritmi di controllo diretto di coppia per motori asincroni

    OpenAIRE

    Rossi, Andrea

    2012-01-01

    Fra le macchine in corrente alternata, il motore asincrono, o più propriamente detto motore ad induzione, è quello che nel passato è stato utilizzato in modo prevalente per moltissime applicazioni industriali che non avevano necessità di controllo di velocità o di coppia. Esso può essere alimentato direttamente dalla corrente alternata di rete monofase o trifase senza alcuna apparecchiatura elettronica di controllo, e nella diffusissima versione con rotore a “gabbia di scoiattolo”, non ric...

  18. Searches for mono-jets and mono-photons with the ATLAS detector

    International Nuclear Information System (INIS)

    Studies of events with a single high energy jet or photon, and large missing transverse momentum at the Large Hadron Collider is one of the most effective ways to search for physics beyond the Standard Model. The background from the Standard Model processes is dominated by jet/photon production associated with Z or W bosons undergoing leptonic decays to neutrinos and/or unidentified electrons or muons. The sensitivity to new physics signals relies on the good understanding and the accurate estimation of these backgrounds, and therefore the use of data-driven techniques is often required. In this article, I will present a compilation of the latest results from the mono-jet and mono-photon searches based on the analysis of the 2011 and 2012 proton-proton collision data collected with the ATLAS detector at a center-of-mass energy of 7 TeV and 8 TeV, respectively. The results are interpreted in the context of various models beyond the Standard Model including large extra dimensions, gauge mediated supersymmetry breaking and effective field theory of dark matter production. (authors)

  19. New mono-organotin (IV) dithiocarbamate complexes

    International Nuclear Information System (INIS)

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S2CNR′R″]2 (R= Ph, CH3, R′ = CH3, C2H5, C7H7 and R″ = C2H5, C6H11, iC3H7, C7H7). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, 1H, 13C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(CN), ν(CS) and ν(Sn-S) band which present in the region of 1444–1519, 954–1098 and 318–349 cm−1 respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of NCS group in the range of 253 – 259 nm due to the intramolecular charge transfer of the ligand. The 13C NMR spectra showed an important shift for δ(N13CS2) in the range of 196.8 – 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S2CN(Et)(i−Pr)]2, MeSnCl[S2CN(Me)(Cy)]2 and MeSnCl[S2CN(i−Pr)(CH2Ph)]2. All structures having a distorted octahedral geometry set by CClS4 donor atom from the two chelating dithiocarbamate ligands

  20. Il ricordo di Bernardo

    Directory of Open Access Journals (Sweden)

    Vincenzo Caporale

    2004-01-01

    Full Text Available Capita, nella vita, di incontrare il dolore perun amico che ci lascia, per un collaboratoreprezioso che non c’è più, per un professionistadi livello che se ne va e scava un vuoto, un buco,che poi non si colma.Ecco, questo è successo a noi dell’IstitutoZooprofilattico Sperimentale dell’Abruzzo e delMolise quando Bernardo Di Emidio, il 23gennaio, è mancato. Abbiamo incontrato undolore grande (e mi perdonerete se parlo delmio, io personalmente in quel dolore sonoinciampato con violenza, perché l’amico DiEmidio aveva condiviso in tutto il tempo in cuiabbiamo lavorato insieme, ogni preoccupazione,tensione, soddisfazione e progettualità.Difficile, per me, è stato ricordarlo proprio ilgiorno dopo la sua morte, in apertura di unconvegno, con la platea piena della gentedell’Istituto e ognuno con gli occhi rossi, losgomento e la solitudine già forte della perditascolpita sul volto. L’abbiamo salutato lì, gli hodetto grazie e ciao da parte di tutti gli altri, manon l’abbiamo mai salutato davvero.Non l’ha ancora fatto nessuno di noi, echissà se lo faremo mai, perché da Bernardonon vogliamo separarci.Sulle pagine di questa rivista, che rendonomerito e onore a tanti ottimi professionisti,proprio su una rivista scientifica, che per ilnostro ambiente è il momento del confronto,spesso «della verità», voglio ricordareBernardo Di Emidio.Voglio ricordarlo all’intera comunitàscientifica per quel grande lavoratore che èstato, per quella piena fiducia che i suoicollaboratori gli davano, per quel bellissimo rapporto che con loro aveva saputo costruire,ricominciando ad ogni nuovo arrivo. Loro, isuoi collaboratori, l’hanno sostenuto fino allafine, hanno continuato a considerarlo il lorocapo, anche durante i momenti più brutti edurante gli ultimi.Non hanno mai fatto a meno del suoparere, della sua approvazione, non si sono allontanati, non si allontano nemmeno oggi, da quel solco di umanità e scientificità che Di Emidio, in anni e

  1. Note di fotonica

    CERN Document Server

    Degiorgio, Vittorio

    2012-01-01

    L’invenzione del laser ha generato una vera rivoluzione nella scienza e nella tecnologia e ha dato luogo alla nascita di una nuova disciplina chiamata Fotonica. Le più importanti applicazioni della Fotonica che hanno un impatto cruciale in molti ambiti della nostra vita sono le comunicazioni in fibra ottica su cui si basa il funzionamento di Internet e del traffico telefonico su grandi distanze, i dischi ottici (CD, DVD, Blue-ray), la sensoristica ottica di tipo industriale e ambientale, la lavorazione dei materiali, l’illuminazione con i LED e la chirurgia. Questo volume ha come obiettivo quello di colmare un vuoto nel panorama italiano di testi universitari riguardanti la Fotonica. Lo scopo principale è quello di esporre in modo sintetico ma rigoroso i concetti che stanno alla base del funzionamento del laser e della propagazione della luce nella materia, e di descrivere i principali componenti e dispositivi ottici e optoelettronici, quali le fibre ottiche, gli amplificatori, i modulatori e i rivelato...

  2. New mono-organotin (IV) dithiocarbamate complexes

    Energy Technology Data Exchange (ETDEWEB)

    Muthalib, Amirah Faizah Abdul; Baba, Ibrahim [School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi (Malaysia)

    2014-09-03

    Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S{sub 2}CNR′R″]{sub 2} (R= Ph, CH{sub 3}, R′ = CH{sub 3}, C{sub 2}H{sub 5}, C{sub 7}H{sub 7} and R″ = C{sub 2}H{sub 5}, C{sub 6}H{sub 11}, iC{sub 3}H{sub 7}, C{sub 7}H{sub 7}). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, {sup 1}H, {sup 13}C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(CN), ν(CS) and ν(Sn-S) band which present in the region of 1444–1519, 954–1098 and 318–349 cm{sup −1} respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of NCS group in the range of 253 – 259 nm due to the intramolecular charge transfer of the ligand. The {sup 13}C NMR spectra showed an important shift for δ(N{sup 13}CS{sub 2}) in the range of 196.8 – 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S{sub 2}CN(Et)(i−Pr)]{sub 2}, MeSnCl[S{sub 2}CN(Me)(Cy)]{sub 2} and MeSnCl[S{sub 2}CN(i−Pr)(CH{sub 2}Ph)]{sub 2}. All structures having a distorted octahedral geometry set by CClS{sub 4} donor atom from the two

  3. Le voci di Orienzio

    OpenAIRE

    Gasti, Fabio

    2008-01-01

    Il commonitorium in distici di Orienzio, da collocarsi nella Gallia delle invasioni barbariche fra 406 e 410, va considerato un tipico prodotto storico-culturale del periodo. L’analisi di due luoghi (1,43-48 e 2,255-262) e l’interpretazione dell’insistita metaforica proemiale della vocalità (1,15-42), ha portato il relatore a documentare come lo scrupolo moralistico di piena e incondizionata adesione alla fede cristiana trovi espressione anche grazie alla lezione formale degli auctores pagani...

  4. Shiatsu Di Jepang

    OpenAIRE

    Simanjuntak, Ricardo

    2015-01-01

    Shiatsu adalah sebuah kata dalam bahasa Jepang yang bila diterjemahkan secara harafiah artinya “tekanan jari”.Hal ini merupakan tekanan jari yang di berikan ke tubuh sebagai metode utama penerapan shiatsu untuk merangsang suatu respon penyembuhan.Namun,shiatsu lebih dari situ.Teknik shiatsu tidak hanya menggunakan jari,tetapi juga ibu jari,telapak tangan,lutut,lengan bawah,siku dan kaki.Lebih jauh lagi,kerena shiatsu dilakukan di lantai dan di tikar ataupun tempat tidur,shiatsu juga focus pad...

  5. Alle origini di Napoli capitale

    OpenAIRE

    Feniello, Amedeo

    2013-01-01

    Scopo di questo articolo è cercare di capire cosa ci sia alle origini di Napoli capitale. Vale a dire, cosa abbia potuto trasformare la capitale di un piccolo ducato autonomo nel centro politico, sociale ed economico di un intero regno, in uno scorcio di tempo relativamente breve – circa un secolo e mezzo, dall'ultimo duca Sergio VII a Carlo I d'Angiò. In questo senso, vengono presi in esame tre aspetti ritenuti essenziali per il raggiungimento dello status di capitale : il porto, la terra, i...

  6. Sorption of mono ethanol amine and mono ethanol aminate of copper(II) and cadmium(II) on hydrated zirconium dioxide

    International Nuclear Information System (INIS)

    The sorption of mono ethanol amine and mono ethanol aminate of copper(II) and cadmium(II) on hydrated zirconium dioxide is studied. Influence of ph of equilibrium solution, nature of central cation and outer-sphere anion on sorption of mono ethanol amine on hydrated zirconium dioxide is considered.

  7. Pairing preferences of the model mono-valence mono-atomic ions investigated by molecular simulation

    International Nuclear Information System (INIS)

    We carried out a series of potential of mean force calculations to study the pairing preferences of a series of model mono-atomic 1:1 ions with evenly varied sizes. The probabilities of forming the contact ion pair (CIP) and the single water separate ion pair (SIP) were presented in the two-dimensional plots with respect to the ion sizes. The pairing preferences reflected in these plots largely agree with the empirical rule of matching ion sizes in the small and big size regions. In the region that the ion sizes are close to the size of the water molecule; however, a significant deviation from this conventional rule is observed. Our further analysis indicated that this deviation originates from the competition between CIP and the water bridging SIP state. The competition is mainly an enthalpy modulated phenomenon in which the existing of the water bridging plays a significant role

  8. Chirotterofauna della provincia di Parma

    OpenAIRE

    Antonio Ruggieri

    2003-01-01

    In questo lavoro viene definito lo stato attuale delle conoscenze sui Chirotteri nella provincia di Parma (regione Emilia Romagna, Nord Italia). Le segnalazioni storiche si riferiscono alla pubblicazione ?I Vertebrati della Provincia di Parma? (Del Prato, 1899) e alla collezione ?Del Prato? conservata presso il Museo dell?Università di Parma. Dal 1995 ho iniziato lo studio della chirotterofauna utilizzando diverse tecniche: ricerca dei siti di rifugio, raccolta occasionale di esemplari feriti...

  9. Manuale di ottica

    CERN Document Server

    Giusfredi, Giovanni

    2015-01-01

    Questo libro costituisce un fondamento solido per la conoscenza dell’Ottica Fisica, presentando vari modi di trattare la propagazione di onde elettromagnetiche e indicando quali siano i metodi utili a specifici casi. Iniziando dall’elettromagnetismo, la riflessione, la rifrazione e la dispersione delle onde, espone argomenti quali l’Ottica Geometrica, l’Interferenza, la Diffrazione, la Coerenza, i fasci Laser, la Polarizzazione, la Cristallografia e l’Anisotropia. Tratta componenti ottici come lenti, specchi, prismi, interferometri classici, Fabry-Perot e cavità risonanti, multistrati dielettrici, filtri interferenziali e spaziali, reticoli di diffrazione, polarizzatori e lamine birifrangenti. Vi sono inoltre argomenti poco reperibili, come il metodo delle matrici 4x4 per lo studio di fronti d’onda generalmente astigmatici, i metodi numerici tramite FFT per il calcolo della diffrazione, e la Bi-anisotropia, che tratta relativisticamente l’attività ottica e gli effetti Faraday e Fresnel-Fizeau....

  10. Note di fotonica

    CERN Document Server

    Degiorgio, Vittorio

    2016-01-01

    L’invenzione del laser ha generato una vera rivoluzione nella scienza e nella tecnologia e ha dato luogo alla nascita di una nuova disciplina chiamata Fotonica. Le applicazioni della Fotonica che hanno un impatto cruciale in molti ambiti della nostra vita sono le comunicazioni in fibra ottica su cui si basa il funzionamento di Internet e del traffico telefonico su grandi distanze, i dischi ottici (CD, DVD, Blu-ray), la sensoristica ottica di tipo industriale e ambientale, la lavorazione dei materiali e la chirurgia con il laser, l’illuminazione con i LED. Questa seconda edizione contiene diversi ampliamenti e modifiche al testo pubblicato nel 2012, che ha colmato un vuoto nel panorama italiano di testi universitari riguardanti la Fotonica. Dopo avere esposto in modo sintetico ma rigoroso i concetti che stanno alla base del funzionamento del laser e della propagazione della luce nella materia, sono descritti i principali componenti e dispositivi ottici e optoelettronici, quali le fibre ottiche, gli amplifi...

  11. Le tecniche di indagine NDT nel processo di restauro e consolidamento di edifici soggetti a tutela

    OpenAIRE

    Costanzo, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Montuori, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Porco, G.; Dipartimento di Ingegneria Civile & SISMILAB s.r.l., Università della Calabria (UniCal), Cosenza, Italy; Casula, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Bologna, Bologna, Italia

    2014-01-01

    Le attività di restauro e consolidamento di edifici soggetti a tutela sono fortemente ancorate alla conoscenza del bene, alla consistenza geometrico-strutturale e a quella materica, nonché all’analisi del degrado del manufatto e del suo stato di conservazione in tutti i suoi elementi. Altri aspetti tecnici da portare in conto sono ovviamente quelli legati al monitoraggio da attuare eventualmente in fase di diagnosi e obbligatoriamente in fase di esercizio, al fine di disporre di una robusta m...

  12. Marie Darrieussecq, Rapporto di polizia. Le accuse di plagio e altri metodi di controllo della scrittura

    Directory of Open Access Journals (Sweden)

    Niccolò Scaffai

    2012-04-01

    Full Text Available A Marie Darrieussecq è successo qualcosa di strano. Non è il fatto di essere nata in Francia, a Bayonne, nel 1969. Né di essere una scrittrice (oltre che una studiosa di letteratura e una psicanalista, che ha pubblicato fiction, racconti autobiografici, saggi letterari. Questo non è così strano. Lo è invece il fatto che metà dei suoi romanzi siano stati considerati, da lettori diversi e soprattutto da altri scrittori, prodotti di «imitazione», «copia», «plagio psichico», o addirittura di «sottrazione di manoscritto»

  13. Konsorsium Perpustakaan di Indonesia

    OpenAIRE

    Gultom, Hetty

    2015-01-01

    Indonesia memiliki banyak (ribuan) perpustakaan tetapi secara umum dapat dikatakan masih sangat lemah dalam memenuhi tuntutan kebutuhan informasi para penggunanya karena mereka beroperasi hanya mengandalkan sumberdaya sendiri secara terisolasi tanpa berkolaborasi antara satu dan lainnya. Kenyataan ini telah disadari para ilmuan dan pimpinan perpustakaan di Indonesia sejak 42 tahun yang lalu dimana pada tahun 1970-an telah terjadi pembentukan jaringan yang cukup banyak di Indonesia (± 36 siste...

  14. Structural characterization and surface-active properties of a new glycolipid biosurfactant, mono-acylated mannosylerythritol lipid, produced from glucose by Pseudozyma antarctica.

    Science.gov (United States)

    Fukuoka, Tokuma; Morita, Tomotake; Konishi, Masaaki; Imura, Tomohiro; Sakai, Hideki; Kitamoto, Dai

    2007-09-01

    Mannosylerythritol lipids (MELs), which are glycolipid biosurfactants produced by Pseudozyma yeasts, show not only excellent interfacial properties but also versatile biochemical actions. In the course of MEL production from glucose as the sole carbon source, P. antarctica was found to produce unknown glycolipids more hydrophilic than conventional "di-acylated MELs," which have two fatty acyl esters on the mannose moiety. Based on a detailed characterization, the most hydrophilic one was identified as 4-O-(3'-O-alka(e)noyl-beta-D: -mannopyranosyl)-D: -erythritol namely, "mono-acylated MEL." The mono-acylated MEL reduced the surface tension of water to 33.8 mN/m at a critical micelle concentration (CMC) of 3.6 x 10(-4) M, and its hydrophilic-lipophilic balance was tentatively calculated to be 12.15. The observed CMC was 100-fold higher than that of the MELs hitherto reported. Interestingly, of the yeast strains of the genus Pseudozyma, only P. antarctica and P. parantarctica gave the mono-acylated MEL from glucose, despite a great diversity of di-acylated MEL producers in the genus. These strains produced MELs including the mono-acylated one at a rate of 20-25%. From these results, the new MEL is likely to have great potential for use in oil-in-water-type emulsifiers and washing detergents because of its higher water solubility compared to conventional MELs and will thus contribute to facilitating a broad range of applications for the environmentally advanced surfactants. PMID:17607573

  15. Retrodatazioni di viaggio

    Directory of Open Access Journals (Sweden)

    Mario Piotti

    2013-07-01

    Full Text Available La letteratura di viaggio, in specie quella sette-ottocentesca, presenta, tra molteplici motivi di interesse, ricchi spunti di indagine anche per la storia della lingua e certamente non è il minore quello relativo agli aspetti lessicali. Nell’articolo non si intende dare una descrizione lessicale completa dei testi odeporici esaminati, ma più limitatamente si presenta una serie cospicua di retrodatazioni e datazioni di parole raccolte in quei testi e quindi ricercate, così allargando lo spettro testuale oltre i limiti della letteratura periegetica, attraverso Google libri. Ma nonostante questo parziale spostamento di sguardo, le schede seguenti continuano a documentare la ricchezza del lessico dell’odeporica: termini scientifici, storici, stranierismi e regionalismi ben testimoniano la varia curiosità dei viaggiatori.  Backdating through travelsSeventeenth and eighteenth century travel literature features, among many points of interest, ideas for researching the history of the language, especially lexical aspects. The article does not intend to give a complete lexical description of the odeporic texts examined, but is limited to a substantial number of backdatings and datings of words collected in those texts, thusgoing beyond the limits of textual periegetic literature, through Google books. Despite this partial shift of attention, we continue to document the richness of odeporic vocabulary: scientifically, historically, through foreign terms and regionalisms, bearing witness to the varied curiosity of travelers.

  16. Identificazione, caratterizzazione ed industrializzazione di ceppi di Streptococcus thermophilus per la produzione di yogurt

    OpenAIRE

    D'Alonges, Sara

    2013-01-01

    Il contesto globale del comparto agro-alimentare richiede ad oggi una ricerca continua per assicurare qualità e sicurezza degli alimenti. La produzione moderna di alimenti richiede elevato grado di standardizzazione, particolarmente la produzione gli alimenti fermentati che include un processo biotecnologico in cui la componente biotica gioca un ruolo fondamentale Di qui la necessità disporre di un’ampia gamma di microrganismi atti alla conduzione del processo fermentativo in modo da im...

  17. Mono-Higgs signature in fermionic dark matter model

    CERN Document Server

    Ghorbani, Karim

    2016-01-01

    In light of Higgs boson discovery, we explore mono-Higgs signature in association with dark matter pair production at the LHC. For two channels with $\\gamma\\gamma+\\text{MET}$ and $b \\bar b+\\text{MET}$ in the final state we simulate the SM backgrounds and signal events at $\\sqrt{s} = 14$ TeV. We then estimate the LHC sensitivities for various benchmark points for two integrated luminosities ${\\cal L} = 300~\\text{fb}^{-1}$ and ${\\cal L} = 3~ \\text{ab}^{-1}$. We constrain the Yukawa coupling of the dark matter-SM interaction, taking into account bounds from mono-Higgs signature, observed dark matter relic density, Higgs physics and perturbativity requirement. Concerning the mono-Higgs search, it turns out that the channel with the largest branching ratio, $b \\bar b$ channel, provides better sensitivity.

  18. Spectroscopic Studies with N-Chloroarylsulphonamides: IR and 1H, 13C and 23Na Nmr Spectra of Sodium Salts of N-Chloro-Mono- and Di-Substituted-Benzenesulphonamides, 4-X-C6H4SO2NANCl (X = H; CH3; C2H5; F; Cl; Br; I or NO2) and i-X, j-YC6H3SO2NANCl (i-X, j-Y = 2,3-(CH3)2; 2,4-(CH3)2; 2,5-(CH3)2; 2-CH3, 4-Cl; 2-CH3, 5-Cl; 3-CH3, 4-Cl; 2,4-Cl2 or 3,4-Cl2)

    Science.gov (United States)

    Gowda; D'Souza, J. D.; Kumar, B. H. Arun

    2003-01-01

    In an effort to introduce N-chloroarylsulphonamides of different oxydising strengths, sixteen sodium salts of N-chloro-mono- and di-substituted benzenesulphonamides of the configuration, 4- X-C6H4SO2NaNCl (where X = H; CH3; C2H5; F; Cl; Br; I or NO2) and i-X, j-YC6H3SO2NaNCl (where i-X, j-Y = 2,3-(CH3)2; 2,4-(CH3)2; 2,5-(CH3)2; 2-CH3,4-Cl; 2-CH3,5-Cl; 3-CH3,4-Cl; 2,4- Cl2 or 3,4-Cl2) are prepared, characterized through their infrared spectra in the solid state and NMR spectra in solution. The υN-Cl frequencies vary in the range 950 - 927 cm-1. Effects of substitution in the benzene ring in terms of electron donating and electron withdrawing groups have been considered, and conclusions drawn. The chemical shifts of aromatic protons and carbon-13 in all the N-chloroarylsulphonamides have been calculated by adding substituent contributions to the shift of benzene. Considering the approximation employed the agreement between the calculated and experimental chemical shift values for different protons or carbon-13 is quite good. Effects of phenyl ring substitution on chemical shift values of both 1H and 13C are also graphically represented in terms of line diagrams.

  19. Radioimmunoassay for mono-(2-ethylhexyl) phthalate in unextracted plasma

    International Nuclear Information System (INIS)

    We report a radioimmunoassay for mono-(2-ethylhexyl) phthalate that has been coupled to a protein carrier as a radioligand. Competitive interference tests with a variety of related compounds indicated the assay to be highly specific. Quantitative comparison of mono-(2-ethylhexyl) phthalate values in plasma and serum samples between the radioimmunoassay and gas chromatographic procedures indicated a high reliability. Because this potentially toxic compound can leach into plasma from polyvinyl plastics, this assay should be particularly useful for those involved in the manufacture or use of medical devices made of them

  20. Synthesis and spectroscopic study of nitroxide mono- and bi- radicals

    International Nuclear Information System (INIS)

    Synthesis and study of nitroxide mono- and bi- radicals derived from oxazolidine: - The first part is the synthesis of amines and radicals, and the I.R. U.V., E.P.R. spectroscopy study. - Conformational analysis of two biradicals has been carried out by measurement of dipolar interaction, on the E.P.R. spectra in the second part. - The final part is an application of N.M.R. study to the determination of the sign and magnitude of nuclear-electron spin-spin couplings and conformations analysis in five mono-radicals. (author)

  1. [Immediately loaded MonoType implants in the edentulous mandible].

    Science.gov (United States)

    Gfeller, F; Zitzmann, N U; Lambrecht, J Thomas

    2011-01-01

    Results of immediately loaded implants are presented. 34 patients with 136 interforaminal MonoType implants (Straumann,Basel, Switzerland) were included in the study. The bar retention was manufactured fter the operation, inserted and covered with a hybrid prosthesis. 28 patients showed up for the follow-up study, the average time range was three years. Five implants were rated as failures, the cumulative six-year success rate being 94%. Interforaminal immediately loaded MonoType implants in edentulous patients showed very good results, comparable to similar studies with different systems. PMID:21560796

  2. Elementi di interfaccia per l’analisi di strutture murarie

    Directory of Open Access Journals (Sweden)

    Jessica Toti

    2009-04-01

    Full Text Available Il presente articolo riguarda la modellazione del comportamento meccanico di elementi in muratura intesi come sistemi eterogenei composti da malta, blocchi ed interfacce di connessione. La strategiacomputazionale che viene adottata consiste nel modellare separatamente i blocchi, i letti di malta ed le interfacce responsabili di fenomeni di decoesione malta-blocco; a tale scopo, si propone uno speciale modello di interfaccia che combina il danneggiamento con l’attrito. Si sviluppa una procedura numerica, basata sull’algoritmo backward di Eulero, per risolvere il problema evolutivo; per il passo temporale si utilizza invece la tecnica predictor-corrector a controllo di spostamenti. Si effettuano alcune applicazioni numeriche con lo scopodi verificare la capacità del modello e dell’algoritmo proposto nel riprodurre la risposta non lineare della muratura dovuta a fenomeni di degrado localizzati. Infine, si conduce lo studio della modellazione di un arco murario, confrontando i risultati numerici con quelli sperimentali; si dimostra la abilità del modello proposto nel simulare il comportamento globale della struttura ad arco in termini di carico ultimo e di meccanismo di collasso.

  3. In ricordo di Vittorio Bianchi

    Directory of Open Access Journals (Sweden)

    Maurizio Cutolo

    2011-09-01

    Full Text Available Vittorio Bianchi fu Ernesto e fu Mary Sbertoli naque a Cogoleto (Genova il 17 febbraio 1919. Laureato in Medicina e Chirurgia presso l’Università di Genova nel 1943 con lode fu Allievo interno della Clinica Medica di Genova negli anni 1942 e 1943, Assistente Volontario alla Clinica Medica di Perugia, quindi della Clinica Medica di Genova negli anni seguenti dove fu nominato Assistente di ruolo per concorso nel 1950. Successivamente Assistente di ruolo alla Patologia Medica diretta dal prof. Aminta Fieschi nel periodo 1954- 1969....

  4. Mono- and binuclear complexes of low-valent zirconium

    OpenAIRE

    Wielstra, IJtsen

    1990-01-01

    This thesis is a study on the synthesis and reactivity of low-valent zirconium. The investigation can be divided in two parts: the first describes the chemistry of mono-cyclopentadienyl Zr (II) complexes (Chapter II, III and IV), and the second describes some synthetic pathways successfully used for the preparation of metallocenic and related type Zr (II) complexes. (Chapter V and VI).

  5. Mono: .NET für alle Plattformen

    OpenAIRE

    Anders, Jörg; Hübner, Uwe

    2004-01-01

    Mono ist eine Open-Source-Implementierung der Software-Entwicklungsplattform .NET. Ein wesentliches Anwendungsgebiet ist die Realisierung von Web-Services. Nach einfachen Beispielen für Web-Services und dazugehörigen Klienten wird ein anspruchsvolleres Beispiel "Kranfernsteuerung" vorgestellt.

  6. Risperidone Mono - Therapy as Prophylaxis in Bipolar Affective Disorders

    OpenAIRE

    Trivedi, Mohit; Pinto, Denzil; Safeekh, A.T.

    2004-01-01

    Risperidone has been found to be useful in the treatment of acute bipolar disorders. This is a case report where risperidone mono therapy has been found to be effective in prophylaxis of bipolar affective disorder. The pharmacological and clinical implications of risperidone in the management of BPAD are discussed

  7. Bepaling van dapson, mono- en diacetyldapson in runderbloedplasma

    OpenAIRE

    Reuver, de, J.L.; Aerts, M.M.L.; Kuiper, H.A.

    1985-01-01

    Doel van dit onderzoek is: het testen van de bepalingsmetheden voor dapson, mono- en diacetyldapson in bloedplasma van melkgevende runderen en het vaststellen van het kinetisch profiel van genoemde stoffen na orale en intramusculaire toediening. Tevens wordt deglucuronidering en eiwitbinding onderzocht.

  8. Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Enevoldsen, I.; Sørensen, John Dalsgaard;

    In this paper a reliability analysis of a Mono-tower platform is presented. The failure modes, considered, are yelding in the tube cross-sections, and fatigue failure in the butt welds. The fatigue failure mode is investigated with a fatigue model, where the fatigue strength is expressed through SN...

  9. Reliability Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Enevoldsen, I.; Sørensen, John Dalsgaard;

    1990-01-01

    In this paper, a reliability analysis of a Mono-tower platform is presented. Te failure modes considered are yielding in the tube cross sections and fatigue failure in the butts welds. The fatigue failrue mode is investigated with a fatigue model, where the fatigue strength is expressed through SN...

  10. Cost-Effective Mass Production of Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Gres, Szymon; Nielsen, Søren Andreas; Fejerskov, Morten;

    2015-01-01

    for innovative and cost-effective design of Mono Bucket foundations. Established approach merges wind and wave load models, soil/structure interaction topics, structural optimization and installation/fabrication aspects, into software package with ability to perform optimal design of the individual foundations...

  11. Geophysical studies of Mono Lake, east-central California

    Science.gov (United States)

    Athens, N. D.; Ponce, D. A.

    2012-12-01

    Magnetic and gravity investigations were undertaken in Mono Lake, California to study regional crustal structures and to aid understanding the geologic framework of Mono Lake, in particular regarding potential geothermal resources and volcanic hazards throughout Mono Basin. Recent geophysical surveys included over 600 line-kilometers of high-resolution ship-borne magnetometer data that augmented existing airborne data, 22 line-kilometers of ground magnetic data that were collected along six traverses across Paoha Island, 56 gravity stations that were collected on Paoha and Negit Islands, and 28 rock samples that were collected for physical property data. Magnetic highs in the study area occur to the east and west of Mono Lake, where pre-Tertiary basement is exposed. Magnetic data indicate that Mono Lake itself is dominated by three prominent magnetic anomalies that are from west to east: a magnetic high along the northwest part of the lake associated with the moderately magnetic basalt cinder cone at Black Point, a magnetic high associated with the young volcanic centers at Paoha and Negit Islands, and a broad magnetic high along the eastern margin of the lake probably associated with moderately magnetic granitic basement rocks at depth. Because volcanic rocks exposed at the surface of Paoha and Negit Islands are only weakly magnetic, magnetic data suggest that more mafic volcanic rocks probably occur at depth and are the source of the anomaly. The linear and steep magnetic gradient across the eastern part of the lake may reflect a fault. A fault may also be imaged in the northeastern part of the lake, where a possible laterally offset magnetic anomaly may be present. Within Mono Lake, gravity station control is poor because land-based gravity stations are limited to Paoha and Negit Islands. The gravity low in the basin reflects a moderately deep sedimentary basin filled with low density lacustrine and volcanic deposits. Isostatic gravity data indicate the central

  12. Stability and Analgesic Efficacy of Di-acetyl Morphine (Diamorphine) Compared with Morphine in Implanted Intrathecal Pumps In Vivo.

    Science.gov (United States)

    Raphael, Jon H; Palfrey, Stephen M; Rayen, Arasu; Southall, Jane L; Labib, Maurad H

    2004-07-01

    The objective of this study was to investigate di-acetyl morphine as an alternative opioid analgesic for use in implanted intrathecal drug delivery systems because of its greater solubility through evaluation of its stability in vivo and analgesic efficacy in the period between pump refills. Contents of intrathecal drug delivery system reservoirs (SynchroMed, Medtronic, Inc., Minneapolis, MN) that had been filled with di-acetyl morphine dissolved in saline (21), bupivacaine (9), or in both bupivacaine and clonidine (19) were sampled in vivo between 1 and 125 days after refill. The samples were assayed for di-acetyl morphine and its breakdown products by micellar electrokinetic capillary chromatography. Prospective daily numerical pain scores between pump refills, using 11-point Likert scales, on 24 patients with implanted SynchroMed pumps (12 delivering di-acetyl morphine in saline, 12 were delivering morphine in saline) were collected. Results showed that di-acetyl morphine immediately started to decay to mono-acetyl morphine in implanted Synchromed pumps with half-life of 50 days. Mono-acetyl morphine decayed to morphine with a maxima estimated at 125 days. There was no clinically significant change in average weekly pain scores for up to ten weeks in either group (range, 2.5 to 2.8 for diamorphine and 2.7 to 3.1 for morphine) (2-way repeated ANOVA, F(9,220) = 0.98, n.s.). We conclude that di-acetyl morphine and its breakdown products, 6 mono-acetyl morphine and morphine, provide similar analgesia to morphine alone when administered by intrathecal pump for a period of at least ten weeks and may be a useful alternative when a more soluble agent is favored. PMID:22151270

  13. Effetti di strutturazione di materiali a base di ossidi inorganici di tipo "aerogel-like" per applicazioni nel campo di catalisi e di isolanti ad alta efficienza

    OpenAIRE

    Padovese, Elena

    2010-01-01

    La nanotecnolgia rappresenta un approccio innovativo nella produzione industriale, e riflette la generale tendenza alla miniaturizzazione ed alla riduzione di scala che prevale in tutte le discipline tecnologiche. Da qui il crescente interesse nei confronti nei nanomateriali e dei materiali nanostrutturati, per lo sviluppo di nuovi prodotti innovativi e tecnologicamente avanzati, che trovino applicazione in molteplici campi. La presente tesi di dottorato si focalizza sulla strutturazione d...

  14. Quaternary Eruptions of the Mono-Inyo Craters, California

    Science.gov (United States)

    Bursik, M. I.; Pouget, S.; Mangan, M.; Marcaida, M.; Vazquez, J. A.

    2013-12-01

    The eruptive products of the Mono-Inyo Craters volcanic chain include the tephra and associated volcanic rocks of Black Point, islands of Mono Lake, Mono Craters, Inyo Craters, late eruptions of Mammoth Mountain and Red Cones. Most of the eruptions were explosive, and generated numerous pyroclastic flows, surges and falls as well as the prominent domes and lava flows that now cover vents. The eruptions range in age from several hundred years to at least 60,000 yr BP. The Mono-Inyo tephras are dispersed throughout the Sierra Nevada and Basin and Range, providing key time-stratigraphic marker layers. Recent work has not only resulted in high-precision radiometric dating of many of the tephras, but also detailed geochemical data that for the first time provides fingerprinting sufficiently precise to discriminate among the tephras. Lithostratigraphy of many of the layers is herein described for the first time, based on careful sampling and description in the field, and laboratory grain size, grain shape and componentry analyses of the late Pleistocene tephras of the Wilson Creek Formation. Most of the Wilson Creek volcanic layers are fall deposits accumulated within paleolake Russell, which were generated by eruptions of variable intensity and influenced by paleowinds of different orientation. Prevailing winds were generally to the North and East, but often the Pleistocene layers less than 25 ka were dispersed to the West. Many of the fall layers show evidence of wave reworking, generally near the top, although in some cases it is pervasive. Only near the vent do some layers of apparent debris flow origin occur. Maximum pumice sizes range up to nearly 3 cm, and lithics range up to 1 cm in the rhyolitic fall beds, while thicknesses range up to c. 30 cm. These data are consistent with relatively low volume, subplinian style eruptive behavior for most of the life of the Mono-Inyo Craters.

  15. Il ricordo di Bernardo

    OpenAIRE

    Vincenzo Caporale

    2004-01-01

    Capita, nella vita, di incontrare il dolore perun amico che ci lascia, per un collaboratoreprezioso che non c’è più, per un professionistadi livello che se ne va e scava un vuoto, un buco,che poi non si colma.Ecco, questo è successo a noi dell’IstitutoZooprofilattico Sperimentale dell’Abruzzo e delMolise quando Bernardo Di Emidio, il 23gennaio, è mancato. Abbiamo incontrato undolore grande (e mi perdonerete se parlo delmio), io personalmente in quel dolore sonoinciampato con violenza, perché ...

  16. Le collezioni di Mammiferi del Museo Civico di Zoologia di Roma: una sintesi storica

    Directory of Open Access Journals (Sweden)

    Gloria Svampa

    2003-10-01

    Full Text Available Il Museo Civico di Zoologia di Roma è sorto nel 1932 all?interno del Giardino Zoologico dell?allora Governatorato di Roma, di cui ha condiviso la direzione tecnica ed amministrativa sino al 1998. Il nucleo centrale delle collezioni è costituito dal materiale di proprietà universitaria, di quello che fu il Museo di Zoologia della Regia Università, a sua volta diretto discendente delle collezioni del Museo di Zoologia ed Anatomia Comparata del Pontificio Archiginnasio Romano. La quasi totalità degli esemplari tassidermizzati risale al periodo in cui l?Istituto di Zoologia fu diretto da Antonio Carruccio (1883-1914. Dal 1932, la collezione teriologica si è andata arricchendo, in particolare di materiale osteologico, soprattutto con acquisizioni provenienti dal Giardino Zoologico e da rare spedizioni scientifiche, come quella organizzata dal CNR nell?Alto Rio Negro del 1962-3, guidata da Ettore Biocca. Anche a causa del fatto che per molti anni il Museo è stato privo di curatori, mancano importanti collezioni teriologiche da studio, fatta eccezione per quella cetologica. In molti casi, singoli esemplari potenzialmente di grande valore scientifico, mancano di dati esatti sulla località di cattura. Nell?ambito di un programma di ricatalogazione della collezione recentemente intrapreso, particolare attenzione è stata posta all?acquisizione di tutti i dati legati alla storia dei singoli esemplari, rintracciabili attraverso i resoconti di viaggio dei singoli esploratori. Nel periodo universitario, infatti, il Museo della nuova capitale d?Italia fu oggetto di grande attenzione da parte di privati ed enti, a partire dai Savoia, che donarono le loro collezioni o il materiale raccolto durante le spedizioni effettuate. Il lavoro di revisione in corso sta mettendo in luce una serie di esemplari meritevoli di ulteriori, dettagliate ricerche. È probabile che molto del materiale del Museo, pervenuto a Roma attraverso donazioni della famiglia reale

  17. Breve Manuale di Geografia Umana

    NARCIS (Netherlands)

    Minca, C.; Colombino, A.

    2012-01-01

    Il percorso per andare al lavoro, la scelta sul dove trascorrere le prossime vacanze, le nostre opinioni sulla politica estera, le nostre preoccupazioni per la crisi economica, le nostre affermazioni di identità, il nostro desiderio di fuga dal quotidiano, perfino la scelta di acquistare una casa in

  18. Inhibition of human platelet phospholipase A/sub 2/ by mono(2-ethylhexyl)phthalate

    Energy Technology Data Exchange (ETDEWEB)

    Labow, R.S.; Meek, E.; Adams, G.A.; Rock, G.

    1988-06-01

    There is evidence that the carcinogenic and teratogenic effects attributed to the plasticizer di(2-ethylhexyl)phthalate (DEHP) are due to its major metabolite mono(2-ethylhexyl)phthalate (MEHP). MEHP is also formed ex vivo by a plasma enzyme in blood products stored in polyvinyl chloride (PVC) DEHP plastic containers. People who receive large amounts of blood products, such as hemophiliacs or patients undergoing hemodialysis, cardiopulmonary bypass, or massive transfusion, are exposed to significant levels of plasticizer. In this study, the platelet was used to show that MEHP inhibits phospholipase A/sub 2/ (PLA/sub 2/), one of the enzymes important in the release of arachidonic acid from membrane phospholipids. PLA/sub 2/ was measured by the liberation of /sup 14/C-arachidonic acid from 1-stearoyl-2-(1-/sup 14/C)arachidonyl-L-3-phosphatidylcholine. MEHP inhibits PLA/sub 2/ activity noncompetitively in intact human platelets and lysates with a K/sub i/ of 3.7 x 10/sup -4/ M. DEHP does not inhibit PLA/sub 2/ in whole platelets. Inhibition of PLA/sub 2/ by MEHP occurs at only three times the circulating level of MEHP measured in neonates undergoing exchange transfusion and 20-fold the levels experienced by patients during cardiopulmonary bypass. Therefore, infants and adult patients with multisystem failure who accumulate MEHP in their blood may be at risk for decreased platelet function.

  19. Mono-(2-ethylhexyl) phthalate induces injury in human umbilical vein endothelial cells.

    Science.gov (United States)

    Ban, Jin-Bao; Fan, Xiao-Wu; Huang, Qi; Li, Bin-Feng; Chen, Chen; Zhang, Hua-Chuan; Xu, Shun-Qing

    2014-01-01

    Mono-(2-ethylhexyl) phthalate (MEHP), the active metabolite of di-(2-ethylhexyl) phthalate (DEHP), is a widespread environmental contaminant and has been proved to have potential adverse effects on the reproductive system, carcinogenicity, liver, kidney and developmental toxicities. However, the effect of MEHP on vascular system remains unclear. The main purpose of this study was to evaluate the cytotoxic effects of MEHP on human umbilical endothelial cells (HUVEC) and its possible molecular mechanism. HUVEC cells were treated with MEHP (0, 6.25, 12.5, 25,50 and 100 µM), and the cellular apoptosis and mitochondrial membrane potential as well as intracellular reactive oxygen species were determined. In present study, MEHP induced a dose-dependent cell injury in HUVEC cell via an apoptosis pathway as characterized by increased percentage of sub-G1, activation of caspase-3, -8 and -9, and increased ratio of Bax/bcl-2 mRNA and protein expression as well as cytochrome C releasing. In addition, there was obvious oxidative stress, represented by decreased glutathione level, increased malondialdehyde level and superoxide dismutase activity. N-Acetylcysteine, as an antioxidant that is a direct reactive oxygen species scavenger, could effectively block MEHP-induced reactive oxygen species generation, mitochondrial membrane potential loss and cell apoptosis. These data indicated that MEHP induced apoptosis in HUVEC cells through a reactive oxygen species-mediated mitochondria-dependent pathway. PMID:24836450

  20. Inhibition of human platelet phospholipase A2 by mono(2-ethylhexyl)phthalate

    International Nuclear Information System (INIS)

    There is evidence that the carcinogenic and teratogenic effects attributed to the plasticizer di(2-ethylhexyl)phthalate (DEHP) are due to its major metabolite mono(2-ethylhexyl)phthalate (MEHP). MEHP is also formed ex vivo by a plasma enzyme in blood products stored in polyvinyl chloride (PVC) DEHP plastic containers. People who receive large amounts of blood products, such as hemophiliacs or patients undergoing hemodialysis, cardiopulmonary bypass, or massive transfusion, are exposed to significant levels of plasticizer. In this study, the platelet was used to show that MEHP inhibits phospholipase A2 (PLA2), one of the enzymes important in the release of arachidonic acid from membrane phospholipids. PLA2 was measured by the liberation of 14C-arachidonic acid from 1-stearoyl-2-[1-14C]arachidonyl-L-3-phosphatidylcholine. MEHP inhibits PLA2 activity noncompetitively in intact human platelets and lysates with a K/sub i/ of 3.7 x 10-4 M. DEHP does not inhibit PLA2 in whole platelets. Inhibition of PLA2 by MEHP occurs at only three times the circulating level of MEHP measured in neonates undergoing exchange transfusion and 20-fold the levels experienced by patients during cardiopulmonary bypass. Therefore, infants and adult patients with multisystem failure who accumulate MEHP in their blood may be at risk for decreased platelet function

  1. Mono-(2-Ethylhexyl) Phthalate Induces Injury in Human Umbilical Vein Endothelial Cells

    Science.gov (United States)

    Huang, Qi; Li, Bin-Feng; Chen, Chen; Zhang, Hua-Chuan; Xu, Shun-Qing

    2014-01-01

    Mono-(2-ethylhexyl) phthalate (MEHP), the active metabolite of di-(2-ethylhexyl) phthalate (DEHP), is a widespread environmental contaminant and has been proved to have potential adverse effects on the reproductive system, carcinogenicity, liver, kidney and developmental toxicities. However, the effect of MEHP on vascular system remains unclear. The main purpose of this study was to evaluate the cytotoxic effects of MEHP on human umbilical endothelial cells (HUVEC) and its possible molecular mechanism. HUVEC cells were treated with MEHP (0, 6.25, 12.5, 25,50 and 100 µM), and the cellular apoptosis and mitochondrial membrane potential as well as intracellular reactive oxygen species were determined. In present study, MEHP induced a dose-dependent cell injury in HUVEC cell via an apoptosis pathway as characterized by increased percentage of sub-G1, activation of caspase-3, -8and -9, and increased ratio of Bax/bcl-2 mRNA and protein expression as well as cytochrome C releasing. In addition, there was obvious oxidative stress, represented by decreased glutathione level, increased malondialdehyde level and superoxide dismutase activity. N-Acetylcysteine, as an antioxidant that is a direct reactive oxygen species scavenger, could effectively block MEHP-induced reactive oxygen species generation, mitochondrial membrane potential loss and cell apoptosis. These data indicated that MEHP induced apoptosis in HUVEC cells through a reactive oxygen species-mediated mitochondria-dependent pathway. PMID:24836450

  2. Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice

    DEFF Research Database (Denmark)

    Hansen, Jitka Stilund; Larsen, Søren Thor; Poulsen, Lars K.;

    2007-01-01

    Phthalates, including di(2-ethylhexyl) phthalate (DEHP), are widely used and have been linked with the development of wheezing and asthma. The main metabolite of DEHP, mono-2-ethylhexyl phthalate (MEHP), was investigated for adjuvant effects in a mouse inhalation model. BALB/cJ mice were exposed to...... aerosols of 0.03 or 0.4 mg/m(3) MEHP 5 days/week for 2 weeks and thereafter weekly for 12 weeks together with a low dose of ovalbumin (OVA) as a model allergen. Mice exposed to OVA alone or OVA+Al(OH)(3) served as negative and positive controls, respectively. Finally, all groups were exposed to a nebulized...... mediated by an IgG1-dependent mechanism. To address implications for humans, a margin-of-exposure was estimated based on the lack of significant effects on IgE production and inflammation after exposures to 0.03 mg/m(3) MEHP observed in the present study and estimated human exposure levels....

  3. Applicazione delle linee guida nazionali nell'attivitá di notifica di casi di legionellosi

    Directory of Open Access Journals (Sweden)

    E. Corsano

    2003-05-01

    Full Text Available

    Obiettivi: é noto che effettuare diagnosi di Legionellosi risulta difficile a causa della sovrapposizione della sintomatologia con altre forme di polmonite. Questo spiega, in parte, perché i casi di Legionellosi siano sottostimati. I metodi diagnostici disponibili, sebbene richiedano tempi relativamente lunghi, sono necessari per l’esatta stima di prevalenza della Legionellosi e per gli eventuali interventi preventivi.

    Metodi: nell’Azienda Ospedaliera “G. Panico” di Tricase, seguendo i criteri delle Linee Guida della Legionellosi (G.U. 5 maggio 2000 n. 103 durante la degenza dei pazienti che presentavano segni clinici ed obiettivi di polmonite sono state eseguite indagini radiologiche (Rx Torace, TAC, esami di laboratorio (espettorato, sangue, urina ed avviata terapia antibiotica (macrolidi e cefalosporine di III generazione. L’antigene urinario e le IgG anti-Legionella (metodo IFA, sono stati determinati in collaborazione con il Laboratorio di riferimento Regionale.

    Risultati: nel periodo ottobre 2001 gennaio 2003 sono stati notificati nel nostro ospedale 11 casi di Legionellosi accertati da indagini clinico-strumentali e di laboratorio: tutti i casi avevano titoli anticorpali abbastanza elevati, confermati poi da un secondo controllo a distanza di tempo. Solo due hanno presentato una positività per l’antigene urinario. All’atto della dimissione, per il 63.6% dei casi è stato documentato un miglioramento delle condizioni clinico-laboratoristico-strumentali, nel 18.2% si è avuta una effettiva guarigione. La letalità è stata pari al 18.2%. In tutti casi si è provveduto alla sorveglianza ambientale.

    Considerazioni: i nostri dati evidenziano che i casi di Legionellosi registrati sono stati tutti di tipo comunitario. Una corretta applicazione delle Linee Guida nel sistema di notifica permette l’avvio dell’attività di prevenzione oltre

  4. Progetto rete di adattamento di un'antenna in microstriscia di tipo Bow-Tie

    OpenAIRE

    Piras, Marcella

    2007-01-01

    Si cerca di ricostruire il profilo di permittivit? di un oggetto, sulla base della misura del campo da esso scatterato, quando viene investito da una radiazione incidente nota (problema dello scattering inverso). L'ispezione dell'oggetto ? non invasiva, in quanto gli esami e i rilievi devono essere condotti impiegando metodi che non alterano il materiale e non richiedono la distruzione o l'asportazione di campioni della struttura in esame. Tra i sensori che vengono utilizzati per questi scopi...

  5. Il Simposio di Platone

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2013-01-01

    Full Text Available Pensate che i testi antichi siano semplicemente vecchi? Che l’amore platonico non vada mai  al sodo? Leggere il Simposio di Platone confrontandosi direttamente col testo, com’è possibile fare grazie al Perseus Project, vi farà cambiare idea.

  6. Ottimizzazione di un protocollo di anticoagulazione regionale con citrato in CRRT

    OpenAIRE

    Ambrosino, Mariacarmela

    2014-01-01

    Ottimizzazione di un protocollo di anticoagulazione regionale con citrato in CRRT Introduzione: La necessità di un'anticoagulazione continua e l'ipofosforemia in corso di trattamento sono problemi costranti in corso di CRRT. Il nostro studio ha cercato di dimostrare l'efficacia e la sicurezza dell'anticoagulazione regionale con citrato in CVVH basato sull'utilizzo di una soluzione di citrato (18 mmol/L) associata ad una soluzione di reinfusione contenente fosfato, recentemente disponibile...

  7. Il Sistema di informazioni del Portogallo: dal sistema dualistico di sicurezza al concetto monistico di sicurezza nazionale

    OpenAIRE

    Marsili, Marco

    2015-01-01

    ITALIAN - Le minacce transnazionali sorte dopo l’11 settembre 2001, impongono agli Stati di rivedere l’organizzazione e la politica di sicurezza. La difficile congiuntura economica e finanziaria, sopravvenuta nel 2008, obbliga i governi a tagli di bilancio, nell’ottica di maggiori risparmi ed efficienze di sistema, attraverso l’uso di strutture e mezzi comuni, e il coordinamento delle forze e dei servizi di sicurezza. Il dibattito sulla militarizzazione della sicu...

  8. Mono- and tetra-substituted zinc(II) phthalocyanines containing morpholinyl moieties: Synthesis, antifungal photodynamic activities, and structure-activity relationships.

    Science.gov (United States)

    Zheng, Bi-Yuan; Ke, Mei-Rong; Lan, Wen-Liang; Hou, Lu; Guo, Jun; Wan, Dong-Hua; Cheong, Ling-Zhi; Huang, Jian-Dong

    2016-05-23

    A series of zinc(II) phthalocyanines (ZnPcs) mono-substituted and tetra-substituted with morpholinyl moieties and their quaternized derivatives have been synthesized and evaluated for their antifungal photodynamic activities toward Candida albicans. The α-substituted, quaternized, and mono-substituted ZnPcs are found to have higher antifungal photoactivity than β-substituted, neutral, and tetra-substituted counterparts. The cationic α-mono-substituted ZnPc (6a) exhibits the highest photocytotoxicity. Moreover, it is more potent than axially di-substituted analogue. The different photocytotoxicities of these compounds have also been rationalized by investigating their spectroscopic and photochemical properties, aggregation trend, partition coefficients, and cellular uptake. The IC90 value of 6a against C. albicans cells is as low as 3.3 μM with a light dose of 27 J cm(-2), meaning that 6a is a promising candidate as the antifungal photosensitizer for future investigations. PMID:27046231

  9. Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6 when used as flavourings for all animal species

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP

    2012-11-01

    Full Text Available Chemical group 6 consists of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers, of which 13 are currently authorised for use as flavours in food. The high use level proposed by the applicant for linalool (25 mg/kg complete feed is safe for salmonids, veal calves, cattle for fattening and pets (excluding cats without a margin of safety with the exception of dogs (SF = 1.4. The safe use level for pigs and dairy cows is 20, for piglets 12 and for poultry 10 mg/kg complete feed. The high use level of 5 mg/kg complete feed for linalyl acetate, linalyl butyrate, linalyl formate, linalyl propionate, linalyl isobutyrate, terpineol, α-terpineol and terpineol acetate and 4-terpinenol is safe for all species with a margin of safety of 1.2 to 12. For nerolidol, 2-methyl-1-phenylpropan-2-ol and 2-(4-methylphenylpropan-2-ol, the maximum safe concentration is 1 mg/kg complete feed for pigs and poultry and 1.5 mg/kg complete feed for all other species. The absence of a margin of safety would not allow the simultaneous administration in feed and water for drinking of the following compounds: linalool, nerolidol, 2-methyl-1-phenylpropan-2-ol and 2-(4methylphenylpropan-2-ol. No safety concern would arise for the consumer from the use of compounds belonging to CG 6 up to the highest safe level in feedingstuffs for all animal species. All compounds should be considered as irritants to skin, eyes and respiratory tract, and as skin sensitisers. All compounds of CG 6 are predicted to be safe to the soil compartment when used at levels safe to the target species. Using predictions based on chemical structure, 2-methyl-1-phenylpropan-2-ol and 2-(4-methylphenylpropan-2-ol were estimated to be safe to aquatic compartments. In the absence of experimental data, safety to aquatic compartments could not be established for linalyl butyrate, linalyl isobutyrate, terpineol acetate, 4

  10. Integrazione rigorosa di dati provenienti da fonti di acquisizione differenti

    Directory of Open Access Journals (Sweden)

    Leandro Bornaz

    2011-04-01

    Full Text Available La geomatica mette oggi a disposizione di esperti di diverse discipline un’ampia gamma di strumenti e tecniche che vengono utilizzate estensivamente come sostegno per l’acquisizione, la contestualizzazione e la georeferenziazione di informazioni molto diversificate come ad esempio dati georadar, geosismici, interferometrici, provenienti da strumenti di misura spesso utilizzati in diversi ambiti e con sistemi di riferimento differenti, talvolta non direttamente compatibili tra loro. Questa problematica, spesso trascurata utilizzando un approccio di tipo classico, è stata affrontata e risolta in modo rigoroso dagli autori permettendo così l’integrazione corretta di dati di differente natura e provenienza.Integration of data acquired from different sourcesGeomatics today offers to experts from different disciplines a wide range of tools and techniques, which are used extensively as technical support for the acquisition, context and geo-refer-encing data coming from different investigations: geo radar, interpherometry, geophysics analysis. Each technology gener-ally provide data with different reference systems, often not di-rectly compatible each other. This problem, often overlooked by using a classical approach, has been resolved in a rigorous way by the authors thus allowing proper integration of data of different nature.

  11. Mono Lake Analog Mars Sample Return Expedition for AMASE

    Science.gov (United States)

    Conrad, P. G.; Steele, A.; Younse, P.; DiCicco, M.; Morgan, A. R.; Backes, P.; Eigenbrode, J. E.; Marquardt, D.; Amundsen, H. E. F.

    2011-01-01

    We explored the performance of one robotic prototype for sample acquisition and caching of martian materials that has been developed at the Jet Propulsion Laboratory for potential use in the proposed MAX-C Mars Sample Return architecture in an environment, rich in chemical diversity with a variety of mineralogical textures. Mono Lake State Tufa Reserve in Mono County, CA possesses a variety of minerals including a variety of evaporites, volcanic glass and lava, and sand and mudstones. The lake itself is an interesting chemical system: the water is highly alkaline (pH is approximately 10) and contains concentrations of Cl, K, B, with lesser amounts of S Ca Mg, F, As, Li, I and Wand generally enriched HREEs. There are also traces of radioactive elements U, Th, Pl.

  12. Studies of mono-crystalline CVD diamond pixel detectors

    Science.gov (United States)

    Bugg, W.; Hollingsworth, M.; Spanier, S.; Yang, Z.; Bartz, E.; Doroshenko, J.; Hits, D.; Schnetzer, S.; Stone, R.; Atramentov, O.; Patel, R.; Barker, A.; Hall-Wilton, R.; Ryjov, V.; Farrow, C.; Pernicka, M.; Steininger, H.; Johns, W.; Halyo, V.; Harrop, B.; Hunt, A.; Marlow, D.; Hebda, P.

    2011-09-01

    The Pixel Luminosity Telescope (PLT) is a dedicated luminosity monitor, presently under construction, for the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC). It measures the particle flux in several three layered pixel diamond detectors that are aligned precisely with respect to each other and the beam direction. At a lower rate it also performs particle track position measurements. The PLT's mono-crystalline CVD diamonds are bump-bonded to the same readout chip used in the silicon pixel system in CMS. Mono-crystalline diamond detectors have many attributes that make them desirable for use in charged particle tracking in radiation hostile environments such as the LHC. In order to further characterize the applicability of diamond technology to charged particle tracking we performed several tests with particle beams that included a measurement of the intrinsic spatial resolution with a high resolution beam telescope.

  13. Studies of mono-crystalline CVD diamond pixel detectors

    CERN Document Server

    Bartz, E; Atramentov, O; Yang, Z; Hall-Wilton, R; Schnetzer, S; Patel, R; Bugg, W; Hebda, P; Halyo, V; Hunt, A; Marlow, D; Steininger, H; Ryjov, V; Hits, D; Spanier, S; Pernicka, M; Johns, W; Doroshenko, J; Hollingsworth, M; Harrop, B; Farrow, C; Stone, R

    2011-01-01

    The Pixel Luminosity Telescope (PLT) is a dedicated luminosity monitor, presently under construction, for the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC). It measures the particle flux in several three layered pixel diamond detectors that are aligned precisely with respect to each other and the beam direction. At a lower rate it also performs particle track position measurements. The PLTs mono-crystalline CVD diamonds are bump-bonded to the same readout chip used in the silicon pixel system in CMS. Mono-crystalline diamond detectors have many attributes that make them desirable for use in charged particle tracking in radiation hostile environments such as the LHC. In order to further characterize the applicability of diamond technology to charged particle tracking we performed several tests with particle beams that included a measurement of the intrinsic spatial resolution with a high resolution beam telescope. Published by Elsevier B.V.

  14. Sviluppo di approcci di gene silencing in vite (Vitis vinifera L.) per studi di genomica funzionale.

    OpenAIRE

    Urso, Simona

    2009-01-01

    Sviluppo di approcci di gene silencing in vite (Vitis vinifera L.) per studi di genomica funzionale. Nel corso del lavoro è stato messo a punto un sistema per la micropropagazione della vite in modo tale da disporre delle piantine durante tutto il corso dell’anno evitando pause di lavoro dovute al fisiologico riposo vegetativo annuale della vite. Utilizzando le banche dati del NSBI, TIGR e IASMA Genomics sono state trovate le sequenze in vite dei geni che regolano la risposta di difesa co...

  15. Miglioramento della qualità di pani tipici pugliesi. Identificazione di batteri lattici con proprietà antimicrobiche e di Bacillus sporigeni isolati da semole di grano duro

    OpenAIRE

    Favilla, Mara

    2010-01-01

    Il lavoro di ricerca ha avuto come obiettivo il miglioramento della qualità microbiologica di pani tipici pugliesi attraverso la selezione di batteri lattici con attività antimicrobica e la caratterizzazione di contaminanti batterici (Bacillus spp.), da semole rimacinate di grano duro. I batteri lattici sono microrganismi da sempre utilizzati nella preparazione di alimenti fermentati tra cui alcuni tipi di pane ottenuti dalla fermentazione del lievito naturale. I prodotti del metabolismo dei ...

  16. Su uno scritto di Frisch del 1933

    OpenAIRE

    Bjerkholt Olav; Qvigstad Jean F.

    2007-01-01

    La Rivista di storia economica è lieta di pubblicare la prima traduzione in lingua inglese degli articoli che Ragnar Frisch pubblicò su giornali norvegesi. Questi scritti prospettano con grande chiarezza, a un largo pubblico, con dichiarate finalità di politica economica, l'antinomia fra il risparmio quale virtù individuale e l'eccesso di risparmio quale vizio macroeconomico. Oltre che per questi profili di teoria macroeconomica, gli scritti di Frisch sono di grande interesse per gli storici ...

  17. Ricerche sugli enterobatteri nelle feci di Chirotteri

    OpenAIRE

    Dino Scaravelli; Paola Massi; Giovanni B. Tosi; Massimo Bertozzi

    2003-01-01

    Dal 2002, grazie al protocollo stipulato tra il gruppo di studio chirotteri del Museo di Onferno e l?Istituto Zooprofilattico Sperimentale della Lombardia e dell?Emilia, sezione di Forlì, si è iniziato un progetto di studio sulla enteroflora di varie specie di Chirotteri. I campioni fecali o più raramente da carcassa, sono stati procssati mediante sistemi standardizzati e tipizzati mediante Enterotubes, creando anche una collezione di riferimento. Le ricerche ad oggi hanno interessato campion...

  18. Electrical properties mono- and polycrystalline silicon solar cells

    OpenAIRE

    L.A. Dobrzański; M. Szczęsna; M. Szindler; A. Drygała

    2013-01-01

    Purpose: The goal of this article was to compare the properties of mono- and polycrystalline silicon solar cells. It was based on measurements performed of current-voltage characteristics and calculated parameters using mathematical formulas. Design/methodology/approach: Light and dark current-voltage characteristics of solar cells were measured using a solar simulator PV Test Solutions company SS150AAA model. The measurements were performed under standard conditions (Pin =...

  19. Gamma spectra pictures using a digital plotter. Program MONO

    International Nuclear Information System (INIS)

    The program MONO has been written for a CALCOMP-936 digital plotter operating off- -line with a UMI VAC 1106 computer, to obtain graphic representations of single gamma spectra stored on magnetic tape. It allows to plot the whole spectrum or only a part, as well as to draw a given spectrum on the same or different picture than the previous one. Ten representation scales are available and at up nine comment lines can be written in a graphic. (Author) 4 refs

  20. Volcanic Geology of Negit Island, Mono Lake, CA

    Science.gov (United States)

    Bursik, M.; Kobs, S.; Jayko, A.

    2008-12-01

    Negit Island, located in Mono Lake, eastern California, is a dacitic cumulodome with seven distinct lava flows emanating from at least four separate vent areas. Vent areas are dominated by en echelon northeast-trending fissures, indicating strong tectonic control. Neptunian(?) pyroclastic deposits on the north end of the island indicate an explosive subaqueous eruption early in island history. Northwestern shorelands, as well as a former landbridge to the island, retain a localized cap of rotated Pleistocene lake bottom sediment blocks, suggesting that proto-Negit was similar to modern Paoha Island, a nearby young structural dome draped with rotated lake bed blocks and explosive ejecta. In analogy with Paoha, the pyroclastic ejecta and blocks may thus indicate sublacustrine block landsliding with attendant eruption as an initial magmatic-structural dome grew, on which later lava domes and flows were superposed. What may be the oldest lava flow, in the center-west, is overlain by a deep orange-red soil, and three Mono Craters tephras. The well-developed soil indicates an extended period of chemical weathering before overlying tephra deposition. The southwestern end of the island is dominated by young lava flows and a prominent dome, which are not overlain by the most recent North Mono Craters tephra of 1350 A.D., consistent with earlier work indicating that parts of the island are younger than any eruption of the Mono Craters. The history of early structural doming with little or minimal eruptive activity at both Negit and Paoha Islands may have important implications for the current episode of noneruptive unrest and doming at nearby Long Valley caldera.

  1. Mono-jet Signatures of Gluphilic Scalar Dark Matter

    OpenAIRE

    Godbole, Rohini M.(Centre for High Energy Physics, Indian Institute of Science, 560012, Bangalore, India); Mendiratta, Gaurav(Center for High Energy Physics, Indian Institute of Science, Bangalore, 560012, India); Shivaji, Ambresh; Tait, Tim M. P.

    2016-01-01

    A gluphilic scalar dark matter (GSDM) model has recently been proposed as an interesting vision for WIMP dark matter communicating dominantly with the Standard Model via gluons. We discuss the collider signature of a hard jet recoiling against missing momentum ("mono-jet") in such a construction, whose leading contribution is at one-loop. We compare the full one-loop computation with an effective field theory (EFT) treatment, and find (as expected) that EFT does not accurately describe region...

  2. Modification and performance evaluation of a mono-valve engine

    Science.gov (United States)

    Behrens, Justin W.

    A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

  3. Mono-2-ethyhexyl phthalate advancing the progression of prostate cancer through activating the hedgehog pathway in LNCaP cells.

    Science.gov (United States)

    Yong, Wang; Jiao, Chen; Jianhui, Wu; Yan, Zhao; Qi, Pan; Xiu, Wang; Zuyue, Sun; Yunhui, Zhang

    2016-04-01

    Hedgehog (Hh) pathway plays a critical role in the progression of prostate cancer (PCa), the most commonly diagnosed non-cutaneous cancer in male adults. Studies showed that di-n-butyl phthalate (DBP) could interference with the Hh pathway. Di-2-ethylhexyl phthalate (DEHP), the congener of DBP, is the major plasticizer used in plastic materials that are inevitably exposed by patients with PCa. The aim of this in vitro study was to investigate whether mono-2-ethyhexyl phthalate (MEHP, the active metabolite of DEHP) could activate the Hh pathway of LNCaP cells. Results showed that the expression of the critical gene of Hh pathway PTCH and androgen-regulated gene KLK3 was significantly decreased on 3, 6 and 9days with Hh pathway inhibitor cyclopamine's treatment. MEHP notably up-regulated the expression of PTCH with a dose-response relationship in the presence of cyclopamine, which indicate that MEHP might target on the downstream components of Hh pathway and advance the progression of PCa through activating the Hh pathway. PMID:26710974

  4. Mono- versus polydrug abuse patterns among publicly funded clients

    Directory of Open Access Journals (Sweden)

    Relyea George

    2007-11-01

    Full Text Available Abstract To examine patterns of mono- versus polydrug abuse, data were obtained from intake records of 69,891 admissions to publicly funded treatment programs in Tennessee between 1998 and 2004. While descriptive statistics were employed to report frequency and patterns of mono- and polydrug abuse by demographic variables and by study years, bivariate logistic regression was applied to assess the probability of being a mono- or polydrug abuser for a number of demographic variables. The researchers found that during the study period 51.3% of admissions reported monodrug abuse and 48.7% reported polydrug abuse. Alcohol, cocaine, and marijuana were the most commonly abused substances, both alone and in combination. Odds ratio favored polydrug abuse for all but one drug category–other drugs. Gender did not affect drug abuse patterns; however, admissions for African Americans and those living in urban areas exhibited higher probabilities of polydrug abuse. Age group also appeared to affect drug abuse patterns, with higher odds of monodrug abuse among minors and adults over 45 years old. The discernable prevalence of polydrug abuse suggests a need for developing effective prevention strategies and treatment plans specific to polydrug abuse.

  5. Nongeocentric axial dipole field behavior during the Mono Lake excursion

    Science.gov (United States)

    Negrini, Robert M.; McCuan, Daniel T.; Horton, Robert A.; Lopez, James D.; Cassata, William S.; Channell, James E. T.; Verosub, Kenneth L.; Knott, Jeffrey R.; Coe, Robert S.; Liddicoat, Joseph C.; Lund, Steven P.; Benson, Larry V.; Sarna-Wojcicki, Andrei M.

    2014-04-01

    A new record of the Mono Lake excursion (MLE) is reported from the Summer Lake Basin of Oregon, USA. Sediment magnetic properties indicate magnetite as the magnetization carrier and imply suitability of the sediments as accurate recorders of the magnetic field including relative paleointensity (RPI) variations. The magnitudes and phases of the declination, inclination, and RPI components of the new record correlate well with other coeval but lower resolution records from western North America including records from the Wilson Creek Formation exposed around Mono Lake. The virtual geomagnetic pole (VGP) path of the new record is similar to that from another high-resolution record of the MLE from Ocean Drilling Program (ODP) Site 919 in the Irminger Basin between Iceland and Greenland but different from the VGP path for the Laschamp excursion (LE), including that found lower in the ODP-919 core. Thus, the prominent excursion recorded at Mono Lake, California, is not the LE but rather one that is several thousands of years younger. The MLE VGP path contains clusters, the locations of which coincide with nonaxial dipole features found in the Holocene geomagnetic field. The clusters are occupied in the same time progression by VGPs from Summer Lake and the Irminger Basin, but the phase of occupation is offset, a behavior that suggests time-transgressive decay and return of the principal field components at the beginning and end of the MLE, respectively, leaving the nonaxial dipole features associated with the clusters dominant during the excursion.

  6. Age of the Mono Lake excursion and associated tephra

    Science.gov (United States)

    Benson, Larry; Liddicoat, Joseph; Smoot, Joseph; Sarna-Wojcicki, Andrei; Negrini, Robert; Lund, Steve

    2003-02-01

    The Mono Lake excursion (MLE) is an important time marker that has been found in lake and marine sediments across much of the Northern Hemisphere. Dating of this event at its type locality, the Mono Basin of California, has yielded controversial results with the most recent effort concluding that the MLE may actually be the Laschamp excursion (Earth Planet. Sci. Lett. 197 (2002) 151). We show that a volcanic tephra (Ash ♯15) that occurs near the midpoint of the MLE has a date (not corrected for reservoir effect) of 28,620±300 14C yr BP (˜32,400 GISP2 yr BP) in the Pyramid Lake Basin of Nevada. Given the location of Ash ♯15 and the duration of the MLE in the Mono Basin, the event occurred between 31,500 and 33,300 GISP2 yr BP, an age range consistent with the position and age of the uppermost of two paleointensity minima in the NAPIS-75 stack that has been associated with the MLE (Philos. Trans. R. Soc. London Ser. A 358 (2000) 1009). The lower paleointensity minimum in the NAPIS-75 stack is considered to be the Laschamp excursion (Philos. Trans. R. Soc. London Ser. A 358 (2000) 1009).

  7. Nel contratto di «service» l'erogatore di energia elettrica non è soggetto passivo di accisa

    OpenAIRE

    Peruzza, D

    2011-01-01

    In materia di accise sull'energia elettrica, soggetto passivo del tributo è il fornitore professionale del bene «energia elettrica» che procede alla fatturazione dell'operazione di vendita in forza di un contratto di somministrazione; il soggetto che fornisce l'energia elettrica a terzi quale componente di una prestazione complessa nell'ambito di un contratto di «service», alla luce del contesto unitario di tale contratto, non può essere considerato soggetto venditore di energia elettrica ...

  8. Meccanismi di censura e rapporti di potere nelle autobiografie collaborative

    Directory of Open Access Journals (Sweden)

    Caterina Romeo

    2015-10-01

    Full Text Available Il genere delle autobiografie collaborative è stato oggetto di una complessa teorizzazione negli ultimi decenni, soprattutto in ambito statunitense, ed è il genere che più di altri segna l'inizio, nei primi anni Novanta, della letteratura postcoloniale italiana e l’incontro linguistico e culturale tra migranti e culture di “accoglienza.” Il presente saggio intende indagare i rapporti di potere presenti all'interno delle autobiografie collaborative e i meccanismi di censura e autocensura operati nella costruzione del testo. Il saggio mette in discussione la presunta trasparenza del ruolo dell'editor e analizza come il rapporto tra narratore ed editor sia al contempo un rapporto di collaborazione e solidarietà, ma anche di sfruttamento coloniale e resistenza postcoloniale.Partendo da una riflessione sui due termini "autobiografia" e "collaborativa" – apparentemente aproblematici ma in realtà fortemente problematici – questo saggio sviluppa un'analisi delle questioni che questo genere letterario pone dal punto di vista teorico – scissione della posizione autoriale, e quindi dell’autorità del soggetto che scrive, rapporti di potere all’interno della collaborazione, censure operate, questioni etiche e rapporti con la critica, resistenza postcoloniale alle grandi narrazioni e riscrittura della storia.L'impianto teorico del presente saggio è costruito soprattutto a partire da testi statunitensi (dagli studi sul testimonio di John Beverley, a quelli sui rapporti di collaborazione come rapporti di sorellanza femminista di Caren Kaplan, agli studi sulle autobiografie native americane. Per quanto riguarda i testi presi in esame, la presente analisi mette a confronto due coppie di testi. I primi due sono l’autobiografia di Nassera Chohra, Volevo diventare bianca (con Alessandra Atti Di Sarro, 1993 e un’importante autobiografia collaborativa italoamericana, Rosa: Life of an Italian Immigrant (con Marie Hall Ets, 1970. Gli altri due

  9. Il percorso di implementazione di un'Unitá Integrata di Day Surgery

    Directory of Open Access Journals (Sweden)

    G. Cattaneo

    2003-05-01

    Full Text Available

    Obiettivi: ottimizzare l’appropriatezza dei ricoveri per i DRG chirurgici, l’utilizzo delle risorse umane e strutturali, aumentare la soddisfazione dei pazienti attraverso la costituzione di un’Unità di Day Surgery (DS e di dedicati percorsi diagnosticoterapeutici. Metodi: È stato costituito un gruppo di lavoro, coordinato dalla Direzione Sanitaria, che ha coinvolto Chirurghi, Anestesisti, Cardiologi Laboratoristi, Radiologi e responsabili amministrativi. Il mandato era di effettuare un’analisi dell’attività chirurgica del presidio e, alla luce della normativa in tema di appropriatezza e controlli sanitari, formulare un’ipotesi di riallocazione delle risorse individuando i percorsi organizzativi da attuare.

    Risultati: l’analisi delle attività chirurgiche e di quella della presenza media per giorno della settimana hanno permesso un intervento di riorganizzazione che, lasciando inalterati i volumi di attività, ha consentito di concentrare in un’unica area le degenze ordinarie di Otorinolaringoiatria, Urologia e Oculistica, recuperando gli spazi ed il personale da destinare alla DS, ed offrendo la possibilità di trasferire ad altri reparti 6 unità infermieristiche e 2 di supporto. Il modello di DS scelto è stata l’Unità centralizzata multidisciplinare, cui afferiscono tutte le Specialità chirurgiche, aperta 5 giorni la settimana dalle 7 alle 17. Sono stati definiti:gli spazi, il personale (6 unità infermieristiche e 1 di supporto, i posti letto (14, la tipologia di interventi da effettuare in regime di DS, il percorso del paziente, i protocolli organizzativi e la modulistica, la gestione amministrativa, gli indicatori.

    Conclusioni: i risultati attesi dall’attivazione della DS sono: miglior rapporto costi/ricavi (costi specifici DRG 162: in regime ordinario 1260,68 Euro; in regime DS 858,80 Euro, erogazione di prestazioni appropriate, allargamento della

  10. Chirotterofauna della provincia di Parma

    Directory of Open Access Journals (Sweden)

    Antonio Ruggieri

    2003-10-01

    Full Text Available In questo lavoro viene definito lo stato attuale delle conoscenze sui Chirotteri nella provincia di Parma (regione Emilia Romagna, Nord Italia. Le segnalazioni storiche si riferiscono alla pubblicazione ?I Vertebrati della Provincia di Parma? (Del Prato, 1899 e alla collezione ?Del Prato? conservata presso il Museo dell?Università di Parma. Dal 1995 ho iniziato lo studio della chirotterofauna utilizzando diverse tecniche: ricerca dei siti di rifugio, raccolta occasionale di esemplari feriti o morti, catture con reti, rilevamento ultrasonico con bat-detector. Il territorio provinciale non è stato indagato omogeneamente poiché ricerche approfondite sono state effettuate solo nelle aree protette. Le specie di Chirotteri sinora accertate per la provincia di Parma sono 19: Rhinolophus ferrumequinum, Rhinolophus hipposideros, Myotis mystacinus, Myotis emarginatus, Myotis bechsteinii, Myotis nattereri, Myotis daubentonii, Myotis myotis, Myotis blythi, Pipistrellus pipistrellus, Pipistrellus nathusii, Pipistrellus kuhlii, Hypsugo savii, Eptesicus serotinus, Nyctalus noctula, Nyctalus leisleri, Plecotus auritus, Barbastella barbastellus, Tadarida teniotis. I dati distributivi di ogni specie sono riportati su una carta suddivisa nel reticolo UTM (griglia di 5 Km di lato.

  11. Studio di metodi di preparazione e caratterizzazione di nanostrutture per la funzionalizzazione di materiali ceramici

    OpenAIRE

    Chiva-Flor, Carla

    2011-01-01

    This thesis was carried out in the context of a co-tutoring program between Centro Ceramico Bologna (Italy) and Instituto di Tecnologia Ceramica, Castellón de la Plana (Spain). The subject of the thesis is the synthesis of silver nanoparticles and at their likely decorative application in the productive process of porcelain ceramic tiles. Silver nanoparticles were chosen as a case study, because metal nanoparticles are thermally stable, and they have non-linear optical properties when nan...

  12. Giornata di Studi Paleontologici

    Directory of Open Access Journals (Sweden)

    Davide Bassi

    2005-09-01

    Full Text Available This book results fromk one-day meeting "Giornata di Studi Paleontologici Prof.ssa C. Loriga Broglio", held in Ferrara on June 18th, 2004 and dedicated to Prof. Carmen Loriga Broglio who was full Professor of Paleontology and Paleoecology at the University of Ferrara.This special volume includes twelve papers dealing with systematic paleontology of calcified cyanobacteria, invertebrates (sponges and vertebrates (fishes, taphonomy, biostratigraphy, paleoecology and paleobiogeography.

  13. [Coraza, relazione di progetto

    OpenAIRE

    Galindo, Regina José

    2013-01-01

    Testo introduttivo ed esplicativo della performance redatto dall’artista in occasione della presentazione della proposta al museo. Il testo è articolato in diverse parti: dopo una introduzione sul concetto di delinquenza e sul ruolo sociale che essa ha secondo Galindo, l’artista affronta la sinossi della perfomance che viene successivamente descritta in tutte le sue fasi. In conclusione l’artista elenca i requisiti necessari alla realizzazione della performance e precisamente: un volontari...

  14. Gamma spectra pictures using a digital plotter. Program MONO; Representacion de Espectros directos mediante un trazado digital. Prograa MONO

    Energy Technology Data Exchange (ETDEWEB)

    Los Arcos, J. M.

    1978-07-01

    The program MONO has been written for a CALCOMP-936 digital plotter operating off- -line with a UMI VAC 1106 computer, to obtain graphic representations of single gamma spectra stored on magnetic tape. It allows to plot the whole spectrum or only a part, as well as to draw a given spectrum on the same or different picture than the previous one. Ten representation scales are available and at up nine comment lines can be written in a graphic. (Author) 4 refs.

  15. Genetic structure and hierarchical population divergence history of Acer mono var. mono in South and Northeast China.

    Directory of Open Access Journals (Sweden)

    Chunping Liu

    Full Text Available Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE, whereas it has a scattered and patchy distribution in South China (SC. In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM. Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species' evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST  = 0.073; G'ST  = 0.278 among all populations, but significantly higher in the SC group than the NE group, mirroring the species' more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study.

  16. Portal Hypertension Promotes Bacterial Translocation in Rats Mono- and Non Mono-Associated with Escherichia Coli C25

    OpenAIRE

    Jean-Nicolas Vauthey; Petra Duda; Anthony M. Wheatley; Philippe Gertsch

    1994-01-01

    The basis for the high incidence of infectious complications in portal hypertension (PHT) remains unclear. The hypothesis that PHT induces bacterial translocation (BT) was tested in a rat model with or without mono-association with streptomycin resistant Escherichia coli C25 and with or without hypovolemic shock. PHT was achieved by partial portal vein ligation and three weeks later hypovolemic shock (HS) was induced. Blood, liver, spleen and mesenteric lymph nodes cultures were performed twe...

  17. Esercizi di metodi matematici della fisica

    CERN Document Server

    Angilella, G G N

    2011-01-01

    Il testo richiama i principali concetti, definizioni e teoremi relativi agli spazi vettoriali, agli sviluppi in serie di Fourier, alle equazioni alle derivate parziali, alle trasformate integrali di Laplace e di Fourier, ad alcune classi di equazioni integrali (con specifico riferimento alla funzione di Green). Si danno altresi' cenni di funzioni di variabile complessa, di teoria dei gruppi, e di spazi funzionali. Di ciascun argomento vengono ampiamente discusse le motivazioni e le applicazioni nel campo della fisica e, talora, di altre discipline scientifiche. Tali argomenti vengono approfonditi da esercizi (perlopiu' svolti, o con soluzione), spesso tratti da effettivi temi d'esame del corso di Metodi matematici per la fisica del corso di laurea in Fisica (Catania).

  18. The relationship between mono-abundance and mono-age stellar populations in the Milky Way disk

    CERN Document Server

    Minchev, I; Chiappini, C; Martig, M; Anders, F; Matijevic, G; de Jong, R S

    2016-01-01

    Studying the Milky Way disk structure using stars in narrow bins of [Fe/H] and [alpha/Fe] has recently been proposed as a powerful method to understand the Galactic thick and thin disk formation. It has been assumed so far that these mono-abundance populations (MAPs) are also coeval, or mono-age, populations. Here we study this relationship for a Milky Way chemo-dynamical model and show that equivalence between MAPs and mono-age populations exists only for the high-[alpha/Fe] tail, where the chemical evolution curves of different Galactic radii are far apart. At lower [alpha/Fe]-values a MAP is composed of stars with a range in ages, even for small observational uncertainties and a small MAP bin size. Due to the disk inside-out formation, for these MAPs younger stars are typically located at larger radii, which results in negative radial age gradients that can be as large as 2 Gyr/kpc. Positive radial age gradients can result for MAPs at the lowest [alpha/Fe] and highest [Fe/H] end. Such variations with age p...

  19. Valutazione del costo di due tipologie di infezioni ospedaliere

    Directory of Open Access Journals (Sweden)

    F. Abbona

    2003-05-01

    Full Text Available

    I tentativi di quantificare le risorse assorbite e definire i costi delle infezioni ospedaliere sono abbastanza sporadici e non sempre metodologicamente corretti. Il principale problema operativo consiste nell’identificare strumenti in grado di verificare sia l’eventuale eccesso di degenza attribuibile all’infezione, sia i costi diretti della infezione dovuti alle risorse impegnate per la diagnosi, il trattamento e l’eventuale monitoraggio del suo decorso.

    A tale scopo si è utilizzato uno strumento, il Protocollo di Revisione dell’Utilizzo dell’Ospedale (PRUO, specificamente modificato, per valutare se la presenza in ospedale era causata dalla sola infezione ospedaliera o dalla patologia di base. L’analisi così condotta permette di distinguere risorse e costi direttamente legati al trattamento delle infezioni da quelli legati alla patologia di base.

    Obiettivo: valutare il costo delle infezioni ospedaliere relative alle vie urinarie e alle sepsi, negli ospedali piemontesi.

    Metodi: la ricerca viene condotta nel periodo dicembre 2002 - settembre 2003, ed interessa 28 Ospedali, della Regione Piemonte, già precedentemente coinvolti (anno 2000 in uno studio di prevalenza sulle infezioni ospedaliere i cui pazienti rappresentano la base dati sulla quale sono stati scelti i casi (59 di infezione oggetto di studio. Per effettuare l’analisi si è proceduto alla consultazione della cartella clinica di ciascun paziente utilizzando il PRUO per raccogliere le informazioni relative alla durata della degenza attribuibile alla sola infezione ospedaliera, all’uso di antibiotici specifici, alle analisi di laboratorio e alle eventuali consulenze effettuate e valorizzando le diverse componenti dei costi con i valori economici forniti dall’ASO S. Luigi di Orbassano, articolati per unità operative in cui si è sviluppata l’infezione ospedaliera. Risultati: sono attualmente disponibili i

  20. Synthesis, spectral and magnetic studies of mono- and bi-nuclear metal complexes of a new bis(tridentate NO2) Schiff base ligand derived from 4,6-diacetylresorcinol and ethanolamine

    Science.gov (United States)

    Shebl, Magdy

    2009-07-01

    A new bis(tridentate NO2) Schiff base ligand, H4L, was prepared by the reaction of the bifunctional carbonyl compound; 4,6-diacetylresorcinol (DAR) with ethanolamine. The ligand reacted with iron(III), cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II), cerium(III) and uranyl(VI) ions, in absence and in presence of LiOH, to yield mono- and bi-nuclear complexes with different coordinating sites. The ligand and its metal complexes were characterized by elemental analyses, IR, 1H NMR, electronic, ESR and mass spectra, conductivity and magnetic susceptibility measurements as well as thermal analyses. In absence of LiOH, mononuclear complexes (2, 3 and 5-9) as well as binuclear complexes (1 and 4) were obtained. In mononuclear complexes, the ligand acted as a neutral, mono- and di-basic/bi- and tetra-dentate ligand while in binuclear complexes (1 and 4), the ligand acted as a bis(mono- or di-basic/tridentate) ligand. On the other hand, in presence of LiOH, only binuclear complexes (10-15) were obtained in which the ligand acted as a bis(dibasic tridentate) ligand. The metal complexes exhibited different geometrical arrangements such as octahedral, tetrahedral, square planar, square pyramidal and pentagonal bipyramidal arrangements.

  1. L'esperienza della Facoltà di Scienze Politiche "Cesare Alfieri" di Firenze

    OpenAIRE

    Cellini, Erika

    2012-01-01

    L’intervento ha l’obiettivo di presentare l’esperienza che la Facoltà di Scienze Politiche di Firenze sta vivendo riguardo alla sensibilizzazione di docenti e studenti rispetto alla questione del plagio. La Facoltà si serve infatti da qualche anno di un software antiplagio ad uso di docenti e studenti e sottopone a controllo obbligato le tesi triennali di tutti i corsi di laurea.

  2. Standardizzazione di un test ELISA indiretto per la ricerca di anticorpi brucellari nel latte di bufala (Bubalus bubalis in Italia

    Directory of Open Access Journals (Sweden)

    Massimo Scacchia

    2011-01-01

    Full Text Available È stata valutato un test ELISA indiretto per rilevare la presenza di anticorpi brucellari nel latte di bufala (Bubalus bubalis Linnaeus, 1758. L’accuratezza della prova è stata valutata su latte proveniente da allevamenti bufalini campani. Sono stati impiegati 100 campioni negativi provenienti da dieci allevamenti ufficialmente indenni della provincia di Salerno e 30 campioni positivi provenienti da tre allevamenti della provincia di Caserta con animali positivi ai test ufficiali e presenza di Brucella abortus biovar 1. La sensibilità della prova è stata del 100% (intervallo di confidenza [IC] del 90,8%-100% e la specificità sui campioni di latte individuale è stata del 98% (IC 93%-99,4%. Al fine di simulare campioni di latte di massa provenienti da allevamenti infetti a varie prevalenze di infezione, sono state analizzate diluizioni da 1:10 a 1:100 di campioni di latte positivo in latte negativo. La probabilità di rilevare anticorpi in campioni di latte positivo è risultata superiore al 50% fino alla diluizione 1:50 in latte negativo. Considerando la consistenza media nazionale degli allevamenti bufalini, la probabilità di individuare l’infezione in un allevamento, ricorrendo alla prova ELISA su latte di massa, è risultata del 50% (IC 33,1%-66,9% qualora nel latte di massa fosse presente il latte di un solo animale infetto.

  3. Narrazioni di narrazioni: orientamento narrativo e progetto di vita (Federico Batini, Gabriel Del Sarto

    Directory of Open Access Journals (Sweden)

    Manuela Ladogana

    2007-03-01

    Full Text Available Il volume, denso di contenuti e ricco di riferimenti teorici, traccia con chiarezza le sue linee di sviluppo ed apre alla riflessione, anche pedagogica, sull’esigenza di recuperare la dimensione narrativa e autobiografica per la realizzazione di una pratica orientativa che guidi e sostenga il soggetto in orientamento verso la riscoperta e ricostruzione del proprio progetto di vita.

  4. Le frontiere di Claudio Magris

    OpenAIRE

    Pellegrini, Ernestina

    2002-01-01

    Questo saggio, che ha la forma eccentrica di appunti, presenta alcune riflessioni in margine al tema della frontiera nell'opera narrativa e saggistica di Claudio Magris. È strutturato in due parti: la prima consiste in un esame ravvicinato dell'ultima sua opera, La mostra, ritratto del pittore triestino Vito Timmel, la seconda, riunisce invece un elenco di citazioni sul motivo del confine estrapolate qua e là dalle opere dello scrittore.

  5. Previdenza pensionistica privata. La legge di delega dell'agosto 2004 e le grandi linee di una riforma di sistema

    OpenAIRE

    Mario Bessone

    2004-01-01

    Previdenza pensionistica privata. La legge delega dell'agosto 2004 e le grandi linee di una riforma di sistema (di Mario Bessone) - ABSTRACT: L’ Autore svolge una serie di considerazioni sulle forme individuali e collettive di previdenza complementare, alla luce dei problemi di uniformazione alle prescrizioni delle direttive comunitarie, delle normative della legge 3 dell’ottobre 2001, che ha riformato il Titolo quinto della Costituzione agli artt. 117 e 118, e propone una analisi critica d...

  6. Studio e realizzazione di una infrastruttura di autenticazione e autorizzazione (AAI) italiana per servizi di biblioteca digitale

    OpenAIRE

    Tenaglia, G.

    2008-01-01

    Obiettivo di questa Tesi di Laurea ? lo studio e la realizzazione di una Infrastruttura di Autenticazione e Autorizzazione Italiana per servizi di biblioteca digitale, proponendo il caso di studio del servizio NILDE. Nel primo capitolo si introducono i concetti principali legati alla gestione dell'identit` a digitale, si fornisce una classificazione dei sistemi e si evidenziano alcuni aspetti interessanti legati alle federazioni d'identit?. Il secondo capitolo presenta alcuni standard e tecno...

  7. Lettura fenomenologica e progetto di paesaggio

    Directory of Open Access Journals (Sweden)

    Alberto Bortolotti

    2008-12-01

    Full Text Available La precarietà degli equilibri paesistici nel nostro tempo, la natura sempre più instabile degli ambiti suburbani ne è il più chiaro esempio, negli ultimi anni ha riportato al centro dell’attenzione di architetti, urbanisti e sociologi, il tema di un progetto di paesaggio connesso alle pratiche di pianificazione territoriale. Ciò ha posto il problema della necessità di considerare le trasformazioni non soltanto in termini di effetti misurabili quantitativamente, ma anche rispetto a condizioni che appartengono più qualitativamente alla sfera emotiva di un abitante o di un visitatore, che dei luoghi in via di trasformazione fanno potenzialmente uso. Su tale aspetto emozionale del modo di abitare e di fare uso dello spazio, si fonda il senso comune di identificazione in una realtà costruita intesa come paesaggio.

  8. Sviluppo di indicatori biologici in organismi acquatici di interesse commerciale esposti a farmaci di rilevanza ambientale

    OpenAIRE

    Kiwan, Alisar

    2016-01-01

    La continua immissione in ambiente dei farmaci ad uso umano, e la loro incompleta rimozione nei depuratori rende questi composti pseudo-persistenti e potenzialmente pericolosi per gli organismi acquatici. La ricerca ha inteso valutare gli effetti sub-letali di farmaci di rilevanza ambientale su due organismi d’interesse commerciale: il mitilo mediterraneo e l’anguilla europea, tramite lo sviluppo e l’applicazione di indicatori biologici, in laboratorio e in campo. Gli studi sull’anguilla h...

  9. KARAKTERISTIK PENGGUNA ???TATTO??? DI KALANGAN PEREMPUAN (Study Karakteristik Pengguna ???Tatto??? Di Kalangan Perempuan Di Kota Makassar

    OpenAIRE

    SARDJU, MARCHELLINO EKO PRASETYO

    2008-01-01

    Nama penulis, Marchellino Eko Prasetyo Sardju. Jurusan Sosiologi di Fisip Unhas. Skripsi ini di bimbing oleh Rahmat Muhammad dan Andi Sangkuru Tato merupakan salah satu karya seni yang memiliki daya tarik tersendiri bagi para peminatnya khusus pada kaum perempuan di kota Makassar. Tato ini juga telah berkembang dari tahun ke tahun. dimana perkembangannya juga diikuti dengan berkembangnya kemajuan teknologi yang memudahkan seseorang untuk membuat Tato. Fenomena Tato pada perempuan ini tent...

  10. Il viaggio gastronomico di Paolo Monelli

    Directory of Open Access Journals (Sweden)

    Alberto Salarelli

    2013-01-01

    Full Text Available Il ghiottone errante di Paolo Monelli, pubblicato nel 1935, rappresenta uno dei primi esempi di narrativa di viaggio in tema di enogastronomia, un genere destinato a grande successo nel secondo dopoguerra. In questo articolo, oltre a ripercorrere la vicenda biografica di Monelli, si sottolineano le relazioni tra Il ghiottone e la cultura gastronomica del regime fascista, e si evidenziano alcuni tratti caratteristici del suo stile di scrittura.

  11. iOS Development using MonoTouch Cookbook

    CERN Document Server

    Tavlikos, Dimitris

    2011-01-01

    The book is written in a cookbook style, presenting examples in the style of recipes, allowing you to go directly to your topic of interest, or follow topics throughout a chapter to gain in-depth knowledge. This book is essential for C# and .NET developers with no previous experience in iOS development and Objective-C developers that want to make a transition to the benefits of MonoTouch and the C# language, for creating complete, compelling iPhone, iPod and iPad applications and deploying them to the App Store.

  12. Antioxidant and cytotoxic activity of mono- and bissalicylic acid derivatives

    OpenAIRE

    Đurendić Evgenija A.; Savić Marina P.; Jovanović-Šanta Suzana S.; Sakač Marija N.; Kojić Vesna V.; Szécsi Mihály; Oklješa Aleksandar M.; Poša Mihalj M.; Penov-Gaši Katarina M.

    2014-01-01

    A simple synthesis of mono- and bis-salicylic acid derivatives 1-10 by the transesterification of methyl salicylate (methyl 2-hydroxybenzoate) with 3-oxapentane-1,5-diol, 3,6- dioxaoctane-1,8-diol, 3,6,9-trioxaundecane-1,11-diol, propane-1,2-diol or 1-aminopropan- 2-ol in alkaline conditions is reported. All compounds were tested in vitro on three malignant cell lines (MCF-7, MDA-MB-231, PC-3) and one non-tumor cell line (MRC- 5). Strong cytotoxicity agains...

  13. Mono- and bis-thiazolium salts have potent antimalarial activity.

    Science.gov (United States)

    Hamzé, Abdallah; Rubi, Eric; Arnal, Pascal; Boisbrun, Michel; Carcel, Carole; Salom-Roig, Xavier; Maynadier, Marjorie; Wein, Sharon; Vial, Henri; Calas, Michèle

    2005-05-19

    Three new series comprising 24 novel cationic choline analogues and consisting of mono- or bis (N or C-5-duplicated) thiazolium salts have been synthesized. Bis-thiazolium salts showed potent antimalarial activity (much superior to monothiazoliums). Among them, bis-thiazolium salts 12 and 13 exhibited IC(50) values of 2.25 nM and 0.65 nM, respectively, against P. falciparum in vitro. These compounds also demonstrated good in vivo activity (ED(50)

  14. Mono-Z dark matter search with the ATLAS detector

    CERN Document Server

    Basalaev, Artem; The ATLAS collaboration

    2016-01-01

    A search with ATLAS detector is presented for collider signatures of weakly interacting dark matter particles (WIMPs) leading to mono-Z signal. Events with large missing transverse momentum and two oppositely-charged electrons or muons consistent with the decay of a Z-boson were selected in analysis. The limits on the mass scale of the contact interaction as a function of the dark matter particle mass and the limits on the coupling and scalar particle mediator obtained from Run 1 ATLAS data are shown. Analysis techniques specific to Run 2 are reviewed.

  15. Mono-Higgs signature in fermionic dark matter model

    OpenAIRE

    Ghorbani, Karim; Khalkhali, Leila

    2016-01-01

    In light of Higgs boson discovery, we explore mono-Higgs signature in association with dark matter pair production at the LHC. For two channels with $\\gamma\\gamma+\\text{MET}$ and $b \\bar b+\\text{MET}$ in the final state we simulate the SM backgrounds and signal events at $\\sqrt{s} = 14$ TeV. We then estimate the LHC sensitivities for various benchmark points for two integrated luminosities ${\\cal L} = 300~\\text{fb}^{-1}$ and ${\\cal L} = 3~ \\text{ab}^{-1}$. We constrain the Yukawa coupling of ...

  16. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF); Scientific Opinion on Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister;

    ether, three are alicyclic hydrocarbons with an ether side chain, two are ethers containing a benzene moiety, eight are phenol ethers and one is a naphthol ether. Five of the 19 candidate substances possess one or more chiral centres and three can exist as geometrical isomers. For one substance [FL...... enable the Panel to make a more realistic estimate of the intakes of the flavouring substances, the Panel has decided also to perform an estimate of the daily intakes per person using a “modified Theoretical Added Maximum Daily Intake” (mTAMDI) approach based on the normal use levels reported by Industry...... levels. According to the default MSDI approach, the 19 flavouring substances in this group have intakes in Europe from 0.011 to 49 micrograms/capita/day, which are below the threshold of concern value for structural class I of 1800 micrograms/person/day, for structural class II of 540 micrograms/person...

  17. Strategie di conservazione dei Chirotteri nel Progetto LIFE "I Chirotteri di Onferno"

    OpenAIRE

    Dino Scaravelli

    2003-01-01

    I Progetti LIFE, nati sull?attivazione di azioni di conservazione per le specie e i siti Natura 2000, sono certamente uno dei più innovativi, complessi e funzionali mezzi del settore. Il progetto NAT00IT7216 ?I Chirotteri di Onferno? si propone di allargare l'azione di conservazione e salvaguardia dei Chirotteri operata dalla Riserva, ed in particolare delle specie prioritarie viventi nel SICp di Onferno, conservando e migliorando gli ambienti di foraggiamento di una comunità di Chirotteri di...

  18. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro

    International Nuclear Information System (INIS)

    Di-2-ethylhexyl phthalate (DEHP) is an environmental contaminant commonly used as a plasticizer in polyvinyl chloride products. Exposure to DEHP has been linked to adverse pregnancy outcomes in humans including preterm birth, low birth-weight, and pregnancy loss. Although oxidative stress is linked to the pathology of adverse pregnancy outcomes, effects of DEHP metabolites, including the active metabolite, mono-2-ethylhexyl phthalate (MEHP), on oxidative stress responses in placental cells have not been previously evaluated. The objective of the current study is to identify MEHP-stimulated oxidative stress responses in human placental cells. We treated a human placental cell line, HTR-8/SVneo, with MEHP and then measured reactive oxygen species (ROS) generation using the dichlorofluorescein assay, oxidized thymine with mass-spectrometry, redox-sensitive gene expression with qRT-PCR, and apoptosis using a luminescence assay for caspase 3/7 activity. Treatment of HTR-8 cells with 180 μM MEHP increased ROS generation, oxidative DNA damage, and caspase 3/7 activity, and resulted in differential expression of redox-sensitive genes. Notably, 90 and 180 μM MEHP significantly induced mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS2), an enzyme important for synthesis of prostaglandins implicated in initiation of labor. The results from the present study are the first to demonstrate that MEHP stimulates oxidative stress responses in placental cells. Furthermore, the MEHP concentrations used were within an order of magnitude of the highest concentrations measured previously in human umbilical cord or maternal serum. The findings from the current study warrant future mechanistic studies of oxidative stress, apoptosis, and prostaglandins as molecular mediators of DEHP/MEHP-associated adverse pregnancy outcomes. - Highlights: ► MEHP increased reactive oxygen species, oxidative DNA damage, and caspase activity. ► MEHP induced expression of PTGS2, a gene

  19. Cytotoxic effects of mono-(2-ethylhexyl) phthalate on human embryonic stem cells

    Institute of Scientific and Technical Information of China (English)

    SHI Cheng; CHEN Xi; CAI Xiao-hui; YU Wei-dong; LIANG Rong; LU Qun; SHEN Huan

    2013-01-01

    Background Mono-(2-ethylhexyl) phthalate (MEHP),the metabolite of di-(2-ethylhexyl) phthalate (DEHP),was suspected to be toxic to human embryos.This study contributes to investigating its toxic effects by an embryonic stem cell test (EST) based on two human embryonic stem cell (hESCs) lines.Methods CH1 established in our own lab and H1,a federally registered cell line were two human embryonic stem cell lines used in this test.Four endpoint measurements were performed consisting of cell viability,proliferation ability,apoptosis as well as changes of gene expression patterns after spontaneous differentiation were determined.For measuring effects on the first three endpoints,the cells were treated with various concentrations of MEHP dissolved in dimethyl sulfoxide (DMSO) and only with DMSO which served as control and harvested after 5 days.For measuring effects during spontaneous differentiation,the RNA of embryoid bodies (EBs) formed after 8 days' MEHP exposure was collected and changes in differentiation specific gene expression patterns were analyzed by quantitative real time RT-PCR.Results As a result the viability and proliferation ability of both cell lines decreased significantly at 1000 μmol/L MEHP,while there was no effect on apoptosis or cell morphology.In addition MEHP also changed the gene expression pattern in the EBs of both cell lines.Conclusion MEHP in a high dose was cytotoxic and affected the development of hESCs,which indicates its embryo toxicity in human embryos.

  20. Re-characterization of mono-2-ethylhexyl phthalate hydrolase belonging to the serine hydrolase family.

    Science.gov (United States)

    Iwata, Makoto; Imaoka, Takuya; Nishiyama, Takashi; Fujii, Takao

    2016-08-01

    A novel bacterium assimilating di-2-ethylhexyl phthalate as a sole carbon source was isolated, and identified as a Rhodococcus species and the strain was named EG-5. The strain has a mono-2-ethylhexyl phthalate (MEHP) hydrolase (EG-5 MehpH), which exhibits some different enzymatic features when compared with the previously reported MEHP hydrolase (P8219 MehpH) from Gordonia sp. These differences include different pH optimum activity, maximal reaction temperature and heat stability. The Km and Vmax values of EG-5 MehpH were significantly higher than those of P8219 MehpH. The primary structure of EG-5 MehpH showed the highest sequence identity to that of P8219 MehpH (39%) among hydrolases. The phylogenetic tree suggested that EG-5 MehpH and P8219 MehpH were categorized in different groups of the novel MEHP hydrolase family. Mutation of a conserved R(109) residue of EG-5 MehpH to a hydrophobic residue resulted in a dramatic reduction in the Vmax value towards MEHP without affecting the Km value. These results indicate that this residue may neutralize the negative charge of a carboxylate anion of MEHP, and thus inhibit the catalytic nucleophile from attacking the ester bond. In other words, the R residue blocks inhibition from the carboxylate anion of MEHP. Recently, registered hypothetical proteins exhibiting 98% or 99% identities for EG-5 MehpH or for P8219 MehpH were found from some pathogens belonging to Actinomycetes. The protein may have other activities besides MEHP hydrolysis and function in other physiological reactions in some Actinomycetes. PMID:26868518

  1. Effect of mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells

    International Nuclear Information System (INIS)

    The phthalate ester mono-(2-ethylhexyl) phthalate (MEHP) is the active metabolite of di-(2-ethylhexyl) phthalate, a high-production-volume chemical used as a plasticizer and solvent in numerous consumer products. MEHP has been demonstrated to be a reproductive toxicant in rodents decreasing estradiol and progesterone production in preovulatory granulosa cells. In the present study, we examined the effect of MEHP on steroid production of human granulosa-lutein (GL) cells. Human GL cells collected from women undergoing in vitro fertilization were cultured in medium containing FSH, hCG and 8-Br-cAMP, respectively, together with various concentrations of MEHP (0-500 μmol L-1). After incubation for 48 h estradiol and progesterone were assayed in the spent culture medium. Furthermore, aromatase activity and mRNA levels of GL cells were determined. Basal as well as FSH-, hCG- and 8-Br-cAMP-stimulated estradiol production of GL cells was suppressed by MEHP in a dose-dependent manner (IC50 = 105 μmol L-1, 138 μmol L-1, 49 μmol L-1 and 78 μmol L-1). Furthermore aromatase activity and mRNA levels were reduced in GL cells cultured with MEHP. In contrast, MEHP did not alter the production of progesterone up to a concentration of 167 μmol L-1. The present data indicate that MEHP is a specific inhibitor of estradiol production in human GL cells with a post-cAMP site of action. The inhibition of estradiol production obviously results from a reduction of aromatase activity on the transcript level. As the in vitro effective doses of MEHP are within the range of real environmental exposure levels an inhibitory effect on estrogen production in vivo seems to be possible.

  2. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Tetz, Lauren M., E-mail: ltetz@umich.edu [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States); Cheng, Adrienne A.; Korte, Cassandra S. [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States); Giese, Roger W.; Wang, Poguang [Department of Pharmaceutical Sciences, Northeastern University, 360 Huntingon Ave, Boston, MA 02115 (United States); Harris, Craig; Meeker, John D.; Loch-Caruso, Rita [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029 (United States)

    2013-04-01

    Di-2-ethylhexyl phthalate (DEHP) is an environmental contaminant commonly used as a plasticizer in polyvinyl chloride products. Exposure to DEHP has been linked to adverse pregnancy outcomes in humans including preterm birth, low birth-weight, and pregnancy loss. Although oxidative stress is linked to the pathology of adverse pregnancy outcomes, effects of DEHP metabolites, including the active metabolite, mono-2-ethylhexyl phthalate (MEHP), on oxidative stress responses in placental cells have not been previously evaluated. The objective of the current study is to identify MEHP-stimulated oxidative stress responses in human placental cells. We treated a human placental cell line, HTR-8/SVneo, with MEHP and then measured reactive oxygen species (ROS) generation using the dichlorofluorescein assay, oxidized thymine with mass-spectrometry, redox-sensitive gene expression with qRT-PCR, and apoptosis using a luminescence assay for caspase 3/7 activity. Treatment of HTR-8 cells with 180 μM MEHP increased ROS generation, oxidative DNA damage, and caspase 3/7 activity, and resulted in differential expression of redox-sensitive genes. Notably, 90 and 180 μM MEHP significantly induced mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS2), an enzyme important for synthesis of prostaglandins implicated in initiation of labor. The results from the present study are the first to demonstrate that MEHP stimulates oxidative stress responses in placental cells. Furthermore, the MEHP concentrations used were within an order of magnitude of the highest concentrations measured previously in human umbilical cord or maternal serum. The findings from the current study warrant future mechanistic studies of oxidative stress, apoptosis, and prostaglandins as molecular mediators of DEHP/MEHP-associated adverse pregnancy outcomes. - Highlights: ► MEHP increased reactive oxygen species, oxidative DNA damage, and caspase activity. ► MEHP induced expression of PTGS2, a gene

  3. Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl phthalate (MEHP.

    Directory of Open Access Journals (Sweden)

    Wenhui Zhai

    Full Text Available Phthalates are extensively used as plasticizers in a variety of daily-life products, resulting in widespread distribution in aquatic environments. However, limited information is available on the endocrine disrupting effects of phthalates in aquatic organisms. The aim of the present study was to examine whether exposure to mono-(2-ethylhexyl phthalate (MEHP, the hydrolytic metabolite of di-(2-ethylhexyl phthalate (DEHP disrupts thyroid endocrine system in fish. In this study, zebrafish (Danio rerio embryos were exposed to different concentrations of MEHP (1.6, 8, 40, and 200 μg/L from 2 h post-fertilization (hpf to 168 hpf. The whole-body content of thyroid hormone and transcription of genes involved in the hypothalamic-pituitary-thyroid (HPT axis were examined. Treatment with MEHP significantly decreased whole-body T4 contents and increased whole-body T3 contents, indicating thyroid endocrine disruption. The upregulation of genes related to thyroid hormone metabolism (Dio2 and UGT1ab might be responsible for decreased T4 contents. Elevated gene transcription of Dio1 was also observed in this study, which might assist to degrade increased T3 contents. Exposure to MEHP also significantly induced transcription of genes involved in thyroid development (Nkx2.1 and Pax8 and thyroid hormone synthesis (TSHβ, NIS and TG. However, the genes encoding proteins involved in TH transport (transthyretin, TTR was transcriptionally significantly down-regulated after exposure to MEHP. Overall, these results demonstrate that acute exposure to MEHP alters whole-body contents of thyroid hormones in zebrafish embryos/larvae and changes the transcription of genes involved in the HPT axis, thus exerting thyroid endocrine toxicity.

  4. Mono-W Dark Matter Signals at the LHC: Simplified Model Analysis

    CERN Document Server

    Bell, Nicole F; Leane, Rebecca K

    2015-01-01

    We study mono-W signals of dark matter (DM) production at the LHC, in the context of gauge invariant renormalizable models. We analyze two simplified models, one involving an s-channel Z' mediator and the other a t-channel colored scalar mediator, and consider examples in which the DM-quark couplings are either isospin conserving or isospin violating after electroweak symmetry breaking. While previous work on mono-W signals have focused on isospin violating EFTs, obtaining very strong limits, we find that isospin violating effects are small once such physics is embedded into a gauge invariant simplified model. We thus find that the 8 TeV mono-W results are much less constraining than those arising from mono-jet searches. Considering both the leptonic (mono-lepton) and hadronic (mono fat jet) decays of the W, we determine the 14 TeV LHC reach of the mono-W searches with 3000 fb$^{-1}$ of data. While a mono-W signal would provide an important complement to a mono-jet discovery channel, existing constraints on t...

  5. Conservazione programmata: i risvolti economici di un cambio di paradigma

    Directory of Open Access Journals (Sweden)

    Stefano Della Torre

    2010-10-01

    Full Text Available La conservazione programmata è una procedura innovativa, pensata come passaggio dal restauro come evento alla conservazione come processo di lungo periodo. Essa è qualcosa di più della manutenzione e del monitoraggio: è una strategia complessa, che riunisce la mitigazione dei rischi di grande scala e una accurata organizzazione delle attività quotidiane. Attuarla è dunque qualcosa di più che fare manutenzione: significa impiantare uno scenario nuovo, ponendo questioni sulle strategie e sui nessi tra le attività conservative e i processi di sviluppo locale.Questo articolo introduce la conservazione programmata come tentativo di andare oltre l’affermazione che il patrimonio conta per il suo impatto sull’economia turistica. Il programma di ricerca si incentra sulle esternalità positive del processo di conservazione. Se il capitale umano è un parametro interessante per valutare un’economia, la conservazione conta per il suo impatto sulla capacità di dubitare, di imparare, di innovare: in altre parole, il focus si sposta dal patrimonio come asset dato, alle attività conservative come opportunità per accrescere il capitale intellettuale.La tesi di fondo è che la conservazione programmata fornisce più esternalità positive, e rende la loro gestione più facile, di quanto non avvenga nel tradizionale modello si restauro/promozione.  Planned conservation is an innovative procedure, stepping from restoration as event, to preservation as long-term process. It is something more than maintenance and monitoring: it is a rather complex strategy, merging a large scale reduction of risks and a careful organization of daily activities. Implementing planned conservation, therefore, is something more effective than implementing maintenance: it means setting a totally new scenario, posing questions about strategies and links between preservation activities and local development processes. This paper introduces planned conservation as an attempt

  6. Di-(2-ethylhexyl phthalate and autism spectrum disorders

    Directory of Open Access Journals (Sweden)

    Giuseppe Latini

    2012-05-01

    Full Text Available ASDs (autism spectrum disorders are a complex group of neurodevelopment disorders, still poorly understood, steadily rising in frequency and treatment refractory. Extensive research has been so far unable to explain the aetiology of this condition, whereas a growing body of evidence suggests the involvement of environmental factors. Phthalates, given their extensive use and their persistence, are ubiquitous environmental contaminants. They are EDs (endocrine disruptors suspected to interfere with neurodevelopment. Therefore they represent interesting candidate risk factors for ASD pathogenesis. The aim of this study was to evaluate the levels of the primary and secondary metabolites of DEHP [di-(2-ethylhexyl phthalate] in children with ASD. A total of 48 children with ASD (male: 36, female: 12; mean age: 11±5 years and age- and sex-comparable 45 HCs (healthy controls; male: 25, female: 20; mean age: 12±5 years were enrolled. A diagnostic methodology, based on the determination of urinary concentrations of DEHP metabolites by HPLC-ESI-MS (HPLC electrospray ionization MS, was applied to urine spot samples. MEHP [mono-(2-ethylhexenyl 1,2-benzenedicarboxylate], 6-OH-MEHP [mono-(2-ethyl-6-hydroxyhexyl 1,2-benzenedicarboxylate], 5-OH-MEHP [mono-(2-ethyl-5-hydroxyhexyl 1,2-benzenedicarboxylate] and 5-oxo-MEHP [mono-(2-ethyl-5-oxohexyl 1,2-benzenedicarboxylate] were measured and compared with unequivocally characterized, pure synthetic compounds (>98% taken as standard. In ASD patients, significant increase in 5-OH-MEHP (52.1%, median 0.18 and 5-oxo-MEHP (46.0%, median 0.096 urinary concentrations were detected, with a significant positive correlation between 5-OH-MEHP and 5-oxo-MEHP (rs = 0.668, P<0.0001. The fully oxidized form 5-oxo-MEHP showed 91.1% specificity in identifying patients with ASDs. Our findings demonstrate for the first time an association between phthalates exposure and ASDs, thus suggesting a previously unrecognized role for

  7. On the generation of mono-implicit Runge-Kutta-Nyström methods by mono-implicit Runge-Kutta methods

    OpenAIRE

    de Meyer, Hans; Vanden Berghe, Guido; Van Hecke, Tanja; Van Daele, Marnix

    1997-01-01

    Mono-implicit Runge-Kutta methods can be used to generate implicit Runge-Kutta-Nystrom (IRKN) methods for the numerical solution of systems of second-order differential equations. The paper is concerned with the investigation of the conditions to be fulfilled by the mono-implicit Runge-Kutta (MIRK) method in order to generate a mono-implicit Runge-Kutta-Nystrom method (MIRKN) that is P-stable. One of the main theoretical results is the property that MIRK methods (in standard form) cannot gene...

  8. MonoSLAM: real-time single camera SLAM.

    Science.gov (United States)

    Davison, Andrew J; Reid, Ian D; Molton, Nicholas D; Stasse, Olivier

    2007-06-01

    We present a real-time algorithm which can recover the 3D trajectory of a monocular camera, moving rapidly through a previously unknown scene. Our system, which we dub MonoSLAM, is the first successful application of the SLAM methodology from mobile robotics to the "pure vision" domain of a single uncontrolled camera, achieving real time but drift-free performance inaccessible to Structure from Motion approaches. The core of the approach is the online creation of a sparse but persistent map of natural landmarks within a probabilistic framework. Our key novel contributions include an active approach to mapping and measurement, the use of a general motion model for smooth camera movement, and solutions for monocular feature initialization and feature orientation estimation. Together, these add up to an extremely efficient and robust algorithm which runs at 30 Hz with standard PC and camera hardware. This work extends the range of robotic systems in which SLAM can be usefully applied, but also opens up new areas. We present applications of MonoSLAM to real-time 3D localization and mapping for a high-performance full-size humanoid robot and live augmented reality with a hand-held camera. PMID:17431302

  9. Electrical properties mono- and polycrystalline silicon solar cells

    Directory of Open Access Journals (Sweden)

    L.A. Dobrzański

    2013-08-01

    Full Text Available Purpose: The goal of this article was to compare the properties of mono- and polycrystalline silicon solar cells. It was based on measurements performed of current-voltage characteristics and calculated parameters using mathematical formulas. Design/methodology/approach: Light and dark current-voltage characteristics of solar cells were measured using a solar simulator PV Test Solutions company SS150AAA model. The measurements were performed under standard conditions (Pin = 1000 W/m2, AM1.5G spectrum, T = 25°C. The basic characteristic of the solar cells were determined using the software SolarLab and calculated using mathematical formulas. Findings: Results and their analysis allow to conclude that measurements of current-voltage characteristics enable characterization of the basic parameters of solar cells. Can give important information about the property of prepared metallic contacts on the solar cells. Practical implications: Knowledge about the current-voltage characteristics of solar cells and their basic parameters enables the assessment of the quality of their production and the improvement. Originality/value: The paper presents some researches of the basic parameters of mono- and polycrystalline solar cells determining the current-voltage characteristics.

  10. Sorveglianza della matrice di varianze e covarianze di un portafoglio efficiente tramite la tecnica lasso

    OpenAIRE

    Gallotti,

    2014-01-01

    Nel mercato finanziario, la scelta ottimale di un portafoglio azionario ha come scopo principale quello di allocare nel miglior modo possibile le risorse a propria disposizione, massimizzando una funzione di utilità che prenda in considerazione sia il rendimento atteso (da massimizzare, a parità di rischio) sia il rischio di investimento (da minimizzare, a parità di rendimento), oppure entrambi gli aspetti simultaneamente. L’idea della tesi trae origine dal concetto di “sorveglianza statis...

  11. Studio caso-controllo multicentrico su distacco di retina e movimentazione manuale di carichi

    OpenAIRE

    Zanardi, Francesca

    2013-01-01

    Obiettivo Valutare l’ipotesi secondo cui la movimentazione manuale di carichi possa essere un fattore di rischio per il di distacco di retina. Metodi Si è condotto uno studio caso-controllo ospedaliero multicentrico, a Bologna, (reparto di Oculistica del policlinico S. Orsola Malpighi, Prof. Campos), e a Brescia (reparto di oculistica “Spedali Civili” Prof. Semeraro). I casi sono 104 pazienti operati per distacco di retina. I controlli sono 173 pazienti reclutati tra l’utenza degli ambulatori...

  12. Sequenze sismiche: La nuova struttura di Pronto Intervento dell’Istituto Nazionale di Geofisica e Vulcanologia

    OpenAIRE

    Govoni, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Abruzzese, L.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Amato, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Basili, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Cattaneo, M.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Chiarabba, C.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Delladio, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Monachesi, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Moretti, M.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Boschi, E.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione AC, Roma, Italia

    2008-01-01

    Fin dai primi anni ‘70, l’Istituto Nazionale di Geofisica e Vulcanologia (INGV, ex ING) si avvale di una struttura di Pronto Intervento in occasione di eventi sismici rilevanti garantendo in tempi relativamente brevi il monitoraggio di dettaglio in area epicentrale. Dal suo primo intervento (terremoto di Ancona 1972) ad oggi, la struttura di Pronto Intervento si è evoluta costantemente implementando migliorie tecnologiche e logistiche. In questo lavoro prensentiamo la nuova struttura im...

  13. Sviluppo di fertilizzanti azotati con inibitore della nitrificazione di origine vegetale

    OpenAIRE

    Di Cillo, Pardo

    2012-01-01

    Le proprietà di inibizione della nitrificazione di sostanze naturali offrono potenziali benefici per l’agricoltura e l’ambiente. Al fine di valutare le performance di oli estratti da Mentha spicata e Artemisia annua e di Acque di Vegetazione delle Olive come inibitori della nitrificazione per regolare la trasformazione dell’azoto dal Solfato Ammonico. Questi effetti sull’efficienza dell’uso dell’azoto sono stati testati su sedano (Apium graveolens). I risultati di questa ricerca suggeriscono ...

  14. Aktiviti ekonomi dan penjanaan haba di beberapa lokasi terpilih di Kuala Lumpur

    OpenAIRE

    Shaharuddin Ahmad; Noraziah Ali

    2011-01-01

    Aktiviti harian penduduk di bandar raya seperti di pejabat, pasar malam, gerai di tepi jalan, kompleks perniagaan, kawasan pelancongan, trafik dan sebagainya memberi impak kepada alam sekitar fizikal. Peningkatan suhu harian dijangkakan berlaku di persekitaran Kuala Lumpur. Sehubungan itu, kajian ini cuba menganalisis fenomena sama di empat kawasan popular aktiviti manusia di sekitar Kuala Lumpur. Kawasan fokus adalah kawasan perniagaan di China Town (Jalan Petaling) dan dibandingkan dengan K...

  15. Esercizi di fisica meccanica e termodinamica

    CERN Document Server

    Dalba, G

    2006-01-01

    La risoluzione di esercizi rappresenta uno strumento indispensabile per raggiungere una comprensione sicura e approfondita dei concetti di Fisica appresi dai corsi e dai testi di teoria. Frutto di una lunga esperienza didattica dei due autori nell'insegnamento universitario della meccanica e della termodinamica, questa raccolta contiene 188 esercizi, di cui 91 completamente risolti ed accompagnati da un ampio corredo di figure. Il peimo capitolo presenta un'introduzione ai sistemi di unità di misura, al calcolo dimensionale, all'uso corretto delle cifre significative e degli arrotondamenti, ai grafici. Gli altri capitoli contengono gli esercizi, suddivisi per argomento e preceduti da una serie di paragrafi riassuntivi dei concetti fondamentali. Criterio ispiratore di questo lavoro è l'adozione di una metodologia per la soluzione degli esercizi basata sempre sull'analisi accurata dei dati a disposizione e sul riferimento ai principi e alle leggi della Fisica, mai alla sola intuizione.

  16. Strategie formulative per la veicolazione nasale di farmaci

    OpenAIRE

    Saladini, Bruno

    2014-01-01

    Microparticelle a base di complessi polielettrolitici di Chitosano/Pectina per il rilascio nasale di Tacrina cloridrato. Lo scopo di questo studio è stata la ricerca di nuove formulazioni solide per la somministrazione nasale di Tacrina cloridrato allo scopo di ridurre l’eccessivo effetto di primo passaggio epatico ed aumentarne la biodisponibilità a livello del Sistema Nervoso Centrale. La Tacrina è stata incapsulata in microparticelle mucoadesive a base di complessi elettrolitici di chitosa...

  17. Alcuni aspetti dell'attività di Eugenio Lazzareschi Direttore dell'Archivio di Stato di Lucca

    OpenAIRE

    Giambastiani, Laura

    2012-01-01

    L'articolo analizza l'attività di Eugenio Lazzareschi come Direttore dell'archivio di stato di Lucca in riferimento alla metodologia archivistica adottata e in particolare focalizza l'attenzione sull'intensa attività svolta per il trasferimento del materiale ritenuto di particolare interesse in luogo sicuro dai disastri della guerra.

  18. 40 CFR 721.1729 - Boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

    Science.gov (United States)

    2010-07-01

    ... polyethylene glycol mono-Bu ether and polyethylene glycol mono Me ether. 721.1729 Section 721.1729 Protection... acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol mono Me ether... identified as boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene......

  19. Sistemi tecnologici innovativi di involucro per il recupero del patrimonio edilizio recente. L'edilizia scolastica nel Comune di Bologna

    OpenAIRE

    Mazzoli, Cecilia

    2015-01-01

    La ricerca è volta a presentare un nuovo approccio integrato, a supporto di operatori e progettisti, per la gestione dell’intero processo progettuale di interventi di riqualificazione energetica e architettonica del patrimonio edilizio recente, mediante l’impiego di soluzioni tecnologiche innovative di involucro edilizio. Lo studio richiede necessariamente l’acquisizione di un repertorio selezionato di sistemi costruttivi di involucro, come base di partenza per l’elaborazione di soluzioni ...

  20. Novita' sul mercato dei sistemi di pagamento: Gli istituti di pagamento e gli istituti di moneta elettronica

    OpenAIRE

    Mancini, Novella

    2014-01-01

    La presente trattazione analizza le novità normative apportate dalle recenti direttive europee sui servizi di pagamento e sulla moneta elettronica (rispettivamente la direttiva 2007/64/CE, c.c. Payment Services Directive o PSD, e la direttiva 2009/110/CE, detta Electronic Money Directive 2 o EMD2). Al fine di incrementare la competitività dei servizi di pagamento, sono stati introdotti nuovi prestatori di servizi di pagamento, non bancari, gli Istituti di Pagamento (IP) e gli Istituti di Mone...

  1. Per un manuale di storia: diacronie e sincronie cronologiche. Una proposta di lavoro di storia regionale sull’Adriatico orientale

    OpenAIRE

    Spazzali, Roberto

    2010-01-01

    L’autore fa inizialmente notare come le conoscenze delle rispettive storie e culture nazionali che oggi possediamo sia di carattere scolastico e fissa per lo più personaggi o fatti appartenenti alla cultura di tipo nazionale. Si tratta di un processo che comporta esclusione e oblio quindi la “non conoscenza”, da cui la necessità di una nuova percezione di cultura e storia. Di seguito passa alla considerazione delle conseguenze fondamentali di alcuni fatti storici che hanno mostrato come sia u...

  2. Di - lambpha cluster states

    International Nuclear Information System (INIS)

    The lightest (p, n, Λ) closed-shell hypernucleus sub(ΛΛ) sup(6)He can be considered as a most likely candidate for the unit of hypernuclear cluster structure. First the internal structure of lambpha, α sub(Λ) = sub(ΛΛ) sup(6)He, is investigated by solving the α + Λ + Λ three-body problem microscopically. The compact h. o. wave function (0 s)6 is found to be a good description for α sub(Λ). Secondly, by using the fully microscopic GCM, we have demonstrated that di - α sub(Λ) cluster states constitute a characteristic rotational band of J = 0+ -- 6+. The E2 transition rate from particle - stable 2+ to 0+ states is predicted to be 2 - order faster than the weak decay rate of this system. (author)

  3. Ricordo di Arturo Rigillo

    Directory of Open Access Journals (Sweden)

    Mario Coletta

    2013-07-01

    Full Text Available Nel pieno imperversare della stagione invernale  del 2010 Arturo Rigillo se ne è andato; in silenzio, così come ha vissuto, lasciando ai familiari, agli amici, ai colleghi dell’ateneo napoletano Federico II, alla comunità scientifica nazionale ed internazionale, al centro di ricerca interdipartimentale L.U.P.T. che lo ha avuto per un decennio  direttore e successivamente presidente, al comitato scientifico e redazionale della rivista  “TRIA”, che con generosa dedizione ha contribuito a fondare, un vuoto che la sola memoria della sua «silenziosa operatività» non potrà certo colmare per i tanti che lo hanno conosciuto, frequentato ed apprezzato condividendo con Lui stima, amicizia ed affetto

  4. Three-dimensional model of the Mono Basin (California): finite element analysis of the interaction between the Hartley Spring Fault and the Mono Dike

    Science.gov (United States)

    La Marra, D.; Manconi, A.; McDonnell, A.; Battaglia, M.

    2012-12-01

    Mono Basin is a northward-trending structural depression lying immediately east of the central Sierra Nevada (California) that extends from the northern edge of Long Valley Caldera towards the center of Mono Lake. The Mono-Inyo Craters volcanic chain forms a prominent 17-km-long arcuate ridge within the Mono Basin. Recent studies have proposed that the volcanism and tectonism in this area is likely interrelated. Stratigraphic data suggest that a series of strong earthquakes occurred during the North Mono-Inyo eruption sequence of 1350 A.D. Geological data are consistent with rupture of the Hartley Springs fault during the eruption sequence. The temporal proximity of these events suggests the possibility of a causal relationship. We use the Finite Element Method (FEM) to generate a three-dimensional model of the Mono Basin and investigate the feedback mechanism between dike intrusion and slip along the Hartley Springs fault. First we combine the potential of the FEM with the Okada (1992) analytical solution for a homogeneous elastic flat half-space to validate our model. Then, to better simulate a geodynamic model of the Mono Basin, we implement more realistic dynamics that include gravity forces, vertical and lateral heterogeneities of the crust, and topography. We evaluate the distribution of local stress changes to study the influence of the Inyo dike intrusion on the Hartley Springs fault and how slip along the fault may encourage the propagation of dikes towards the surface. We employ the Coulomb stress change as a failure criterion on the Hartley Springs fault. Preliminary results indicate that slip along the Hartley Springs fault may have encouraged the intrusion of the Mono Dike.

  5. Sviluppo di materiali polimerici e delle loro relative tecnologie di trasformazione per la loro integrazione nella realizzazione di microdispositivi elettronici

    OpenAIRE

    De Simone, Luigi

    2006-01-01

    Obiettivo del presente lavoro di tesi è stato l’individuazione e la caratterizzazione di substrati polimerici, alternativi ai convenzionali substrati vetrosi, per la realizzazione di microdispositivi elettronici mediante la tecnologia Polysilicon che si basa sull’utilizzo di materiali semiconduttori a film sottile di silicio policristallino depositati a basse temperature. La riduzione dei costi, del peso e la maggiore robustezza meccanica sono tra i principali vantaggi previsti dall’utilizzo ...

  6. Analisi dei modi di vibrazione di un edificio campione in muratura mediante registrazioni di terremoti e modellazioni numeriche.

    OpenAIRE

    Pucillo, S.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Fodarella, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Cogliano, R.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Di Giulio, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Minichiello, V.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Riccio, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Rovelli, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia

    2009-01-01

    Nella pratica ingegneristica vengono usate correlazioni derivate da regressioni statistiche tra numero dei piani degli edifici e frequenze di risonanza. Tuttavia la discrepanza tra comportamento reale e valori aspettati può essere talvolta significativa, e solo l’acquisizione di dati sperimentali consente di comprendere il reale comportamento dinamico di una struttura. La sperimentazione, in situazioni anche complesse, e la raccolta di nuovi dati possono essere molto importanti nel campo dell...

  7. Marie Darrieussecq, Rapporto di polizia. Le accuse di plagio e altri metodi di controllo della scrittura

    OpenAIRE

    Niccolò Scaffai

    2012-01-01

    A Marie Darrieussecq è successo qualcosa di strano. Non è il fatto di essere nata in Francia, a Bayonne, nel 1969. Né di essere una scrittrice (oltre che una studiosa di letteratura e una psicanalista), che ha pubblicato fiction, racconti autobiografici, saggi letterari. Questo non è così strano. Lo è invece il fatto che metà dei suoi romanzi siano stati considerati, da lettori diversi e soprattutto da altri scrittori, prodotti di «imitaz...

  8. ISTALLAZIONE DI UNA STAZIONE PER LA RIVELAZIONE CONTINUA RADON MEDIANTE SPETTROMETRIA ALFA NELLA SOLFATARA DI POZZUOLI

    OpenAIRE

    De Cesare, W.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione OV, Napoli, Italia; Scarpato, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione OV, Napoli, Italia; Buonocunto, C.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione OV, Napoli, Italia; Caputo, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione OV, Napoli, Italia; Capello, M.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione OV, Napoli, Italia; Avino, R.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione OV, Napoli, Italia; Roca, V.; Istituto Nazionale di Fisica Nucleare (Sezione di Napoli); De Cicco, F.; Istituto Nazionale di Fisica Nucleare (Sezione di Napoli); Pugliese, M. G.; Istituto Nazionale di Fisica Nucleare (Sezione di Napoli); Sabbarese, C.; Seconda Università degli Studi di Napoli (Dipartimento di Scienze Ambientali); Giudicepietro, F.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione OV, Napoli, Italia

    2011-01-01

    La realizzazione della stazione descritta nel presente rapporto è frutto di una collaborazione tra ricercatori della Sezione di Napoli dell’ Istituto Nazionale di Fisica Nucleare (INFN) e ricercatori dell’Osservatorio Vesuviano (OV), Sezione di Napoli dell’Istituto Nazionale di Geofisica e Vulcanologia (INGV), e costituisce un’attività sperimentale per il monitoraggio dell’attività vulcanica dei Campi Flegrei.

  9. La Basilica di Vitruvio di Fano: un approccio di archeologia sperimentale per la validazione di un modello 3D

    Directory of Open Access Journals (Sweden)

    Paolo Clini

    2014-04-01

    Full Text Available IT La vicenda della Basilica di Vitruvio di Fano ha da sempre destato un grande interesse tra studiosi e archeologi e da diversi anni è oggetto di studio di un gruppo di ricerca del DICEA della Facoltà d’Ingegneria dell’Università Politecnica delle Marche di Ancona, in collaborazione con il Centro Studi Vitruviani. Seppur già lungamente nei secoli si è discusso sull’interpretazione del testo, limitandosi però a descrizioni formali della fabbrica, il nostro interesse si è invece concentrato, grazie anche allo sviluppo tecnologico di questi ultimi decenni, sugli aspetti statici e strutturali dell’unico edificio di cui Vitruvio curò la progettazione e la realizzazione. E’ stato quindi possibile realizzare un modello virtuale su cui effettuare una serie di simulazioni strutturali e illuminotecniche, secondo i canoni dell’archeologia sperimentale. Con un approccio volto sempre più all’interdisciplinarietà, ripercorrendo criticamente la storiografia della basilica, il lavoro apre nuove riflessioni su un’ipotesi in cui la forma, la struttura e le tecniche costruttive possono finalmente concordare permettendoci così, interagendo reciprocamente, di aprire nuovi ambiti di ipotesi rispetto al mancato ritrovamento di resti e ai possibili motivi della eventuale scomparsa della fabbrica.ENVitruvius’s Basilica has always been a subject of great interest among academics and archaeologists and it has been investigated by the engineering department of Marche Polytechnic University of Ancona, in partnership with Centro Studi Vitruviani for many years now. Even though the discussion about the text interpretation went on for a long time during the centuries, mainly concerning the shape of the building, on the other hand our interest, due to the technological progress of the last decades, is focused on static and structural features of the only building that Vitruvius drew and built. Thus it was possible to reproduce structural and

  10. Synthesis and Photocytotoxicity of Mono-functionalised Porphyrin with Valine Moiety

    Institute of Scientific and Technical Information of China (English)

    Wei Min SHI; Jian WU; Yi Feng WU; Kai Xian QIAN

    2004-01-01

    A mono-funtionalised tetraphenylporphyrin (TPP) bearing valine moiety at the phenyl ring was synthesized for photocytotoxicity examination in four steps, starting from regiospecific mono-nitration of TPP at the phenyl ring. The in vitro photocytotoxicitic effect against SPC-A1 adenocarcinona cell line was tested.

  11. Synthesis, purification, and time-dependent disposition studies of 9- or 10-mono-iodostearic acid and 9- and 10-mono-iodostearyl carnitine

    International Nuclear Information System (INIS)

    The purpose of this investigation was to evaluate the potential use of radiolabeled 9- or 10-mono-iodostearyl carnitine as a perfusion and metabolic imaging agent for the heart. Radiochemical purity was achieved and determined by the use of silica gel and/or anion exchange resin chromatography. Radiochemical yields of 45-63 and 4% were obtained for the fatty acid and carnitine ester, respectively. Male albino mice were sacrificed at 2, 5, 7, 10, 15, 20, 30, and 50 minutes post-injection with either 125I 9- or 10-mono-iodostearic acid or 9- or 10-mono-iodostearyl (-) carnitine. The lungs, liver heart, kidney, spleen, pancreas, small intestine, stomach, thyroid, blood, fat, and skeletal muscle tissue were excised and assayed for levels of radioactivity in a NaI crystal well counter. The very low target-to-nontarget ratios obtained with 125I 9- or 10-mono-iodostearyl carnitine in mice strongly suggest that radioiodinated 9- or 10-mono-iodostearyl carnitine is not suitable for use as a myocardial imaging agent. However, radioiodinated 9- or 10-mono-iodostearic acid showed promise as a myocardial imaging agent and may warrant further investigation

  12. Aryl hydrocarbon mono-oxygenase activity in human lymphocytes

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, G.D.; Schuresko, D.D.

    1981-06-01

    Aryl hydrocarbon mono-oxygenase (AHM), an enzyme of key importance in metabolism of xenobiotic chemicals such as polynuclear aromatic hydrocarbons (PNA), is present in human lymphocytes. Studies investing the relation of activity of AHM in human lymphocytes to parameters such as disease state, PNA exposure, in vitro mitogen stimulation, etc. have been summarized in this report. Some studies have demonstrated increased AHM activity in lymphocytes from cigarette smokers (compared to nonsmokers), and in lung cancer patients when compared to appropriate control groups. These observations are confused by extreme variability in human lymphocyte AHM activities, such variability arising from factors such as genetic variation in AHM activity, variation in in vitro culture conditions which affect AHM activity, and the problematical relationship of common AHM assays to actual PNA metabolism taking place in lymphocytes. If some of the foregoing problems can be adequately addressed, lymphocyte AHM activity could hold the promise of being a useful biomarker system for human PNA exposure.

  13. Mono-Higgs Detection of Dark Matter at the LHC

    CERN Document Server

    Berlin, Asher; Wang, Lian-Tao

    2014-01-01

    Motivated by the recent discovery of the Higgs boson, we investigate the possibility that a missing energy plus Higgs final state is the dominant signal channel for dark matter at the LHC. We consider examples of higher-dimension operators where a Higgs and dark matter pair are produced through an off-shell Z or photon, finding potential sensitivity at the LHC to cutoff scales of around a few hundred GeV. We generalize this production mechanism to a simplified model by introducing a Z' as well as a second Higgs doublet, where the pseudoscalar couples to dark matter. Resonant production of the Z' which decays to a Higgs plus invisible particles gives rise to a potential mono-Higgs signal. This may be observable at the 14 TeV LHC at low tan beta and when the Z' mass is roughly in the range 600 GeV to 1.3 TeV.

  14. Mechanically flexible optically transparent porous mono-crystalline silicon substrate

    KAUST Repository

    Rojas, Jhonathan Prieto

    2012-01-01

    For the first time, we present a simple process to fabricate a thin (≥5μm), mechanically flexible, optically transparent, porous mono-crystalline silicon substrate. Relying only on reactive ion etching steps, we are able to controllably peel off a thin layer of the original substrate. This scheme is cost favorable as it uses a low-cost silicon <100> wafer and furthermore it has the potential for recycling the remaining part of the wafer that otherwise would be lost and wasted during conventional back-grinding process. Due to its porosity, it shows see-through transparency and potential for flexible membrane applications, neural probing and such. Our process can offer flexible, transparent silicon from post high-thermal budget processed device wafer to retain the high performance electronics on flexible substrates. © 2012 IEEE.

  15. Mono-jet Signatures of Gluphilic Scalar Dark Matter

    CERN Document Server

    Godbole, Rohini M; Shivaji, Ambresh; Tait, Tim M P

    2016-01-01

    A gluphilic scalar dark matter (GSDM) model has recently been proposed as an interesting vision for WIMP dark matter communicating dominantly with the Standard Model via gluons. We discuss the collider signature of a hard jet recoiling against missing momentum ("mono-jet") in such a construction, whose leading contribution is at one-loop. We compare the full one-loop computation with an effective field theory (EFT) treatment, and find (as expected) that EFT does not accurately describe regions of parameter space where mass of the colored mediator particles are comparable to the experimental cuts on the missing energy. We determine bounds (for several choices of SU(3) representation of the mediator) from the $\\sqrt{s}=$ 8 TeV data, and show the expected reach of the $\\sqrt{s}=$ 13 TeV LHC and a future 100 TeV $pp$ collider to constrain or discover GSDM models.

  16. Fatigue Analysis of a Mono-Tower Platform

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

    In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...... through linear-elastic fracture mechanics (LEFM). In determining the cumulative fatigue damage, Palmgren-Miner's rule is applied. Element reliability as well as systems reliability is estimated using first-order reliability methods (FORM). The sensitivity of the systems reliability to various parameters...... is investigated. The systems reliability index, estimated by using the fatigue elements with the fatigue strength expressed through SN relations, is found to be smaller than the systems reliability index estimated by using LEFM. It is shown that the systems reliability index is very sensitive to...

  17. PET imaging of alphavbeta integrin expression in tumours with Ga-labelled mono-, di- and tetrameric RGD peptides

    NARCIS (Netherlands)

    Dijkgraaf, I.; Yim, C.B.; Franssen, G.M.; Schuit, R.C.; Luurtsema, G.; Liu, S.; Oyen, W.J.G.; Boerman, O.C.

    2011-01-01

    PURPOSE: Due to the restricted expression of alpha(v)beta(3) in tumours, alpha(v)beta(3) is considered a suitable receptor for tumour targeting. In this study the alpha(v)beta(3)-binding characteristics of (68)Ga-labelled monomeric, dimeric and tetrameric RGD peptides were determined and compared wi

  18. Biologically relevant mono- and di-nuclear manganese II/III/IV complexes of mononegative pentadentate ligands

    DEFF Research Database (Denmark)

    Baffert, Carole; Collomb, Marie-Nöelle; Deronzier, Alain;

    2003-01-01

    magnetic coupling interaction is weak and antiferromagnetic, J = -1.3(1) cm(-1). The dimeric structures of 1 and 2 are retained in solution and can exist in the gas phase. Complexes 1 and 2 are air stable but can be oxidised by (BuOOH)-Bu-t to give unstable mononuclear Mn(III) complexes, or oxo...... the highest oxidation state products detected, and these are formed via shorter-lived intermediate mu-oxo-dimanganese(III) compounds. The rate of formation of the various oxidized products is slower in the case of the bzgbpen(-) systems which contains a bulkier non-coordinating arm. The oxidised...... complexes were characterised by UV-visible spectroscopy, ESI mass spectrometry and cyclic voltammetry. In addition, III-IV and II-III species were electrochemically generated. Thus the new mononegative pentadentate ligand systems display significant flexibility in the range of Mn oxidation states and...

  19. CO 2 adsorption in mono-, di- and trivalent cation-exchanged metal-organic frameworks: A molecular simulation study

    KAUST Repository

    Chen, Yifei

    2012-02-28

    A molecular simulation study is reported for CO 2 adsorption in rho zeolite-like metal-organic framework (rho-ZMOF) exchanged with a series of cations (Na +, K +, Rb +, Cs +, Mg 2+, Ca 2+, and Al 3+). The isosteric heat and Henry\\'s constant at infinite dilution increase monotonically with increasing charge-to-diameter ratio of cation (Cs + < Rb + < K + < Na + < Ca 2+ < Mg 2+ < Al 3+). At low pressures, cations act as preferential adsorption sites for CO 2 and the capacity follows the charge-to-diameter ratio. However, the free volume of framework becomes predominant with increasing pressure and Mg-rho-ZMOF appears to possess the highest saturation capacity. The equilibrium locations of cations are observed to shift slightly upon CO 2 adsorption. Furthermore, the adsorption selectivity of CO 2/H 2 mixture increases as Cs + < Rb + < K + < Na + < Ca 2+ < Mg 2+ ≈ Al 3+. At ambient conditions, the selectivity is in the range of 800-3000 and significantly higher than in other nanoporous materials. In the presence of 0.1% H 2O, the selectivity decreases drastically because of the competitive adsorption between H 2O and CO 2, and shows a similar value in all of the cation-exchanged rho-ZMOFs. This simulation study provides microscopic insight into the important role of cations in governing gas adsorption and separation, and suggests that the performance of ionic rho-ZMOF can be tailored by cations. © 2012 American Chemical Society.

  20. Synthesis, photophysical and metal ion signalling behaviour of mono- and di-azacrown derivatives of 4-aminophthalimide

    Indian Academy of Sciences (India)

    N B Sankaran; M Sarkar; A Samanta

    2005-03-01

    Synthesis, photophysical behaviour and metal ion signalling ability of 3-component systems, I and II, comprising a 4-aminophthalimido moiety as fluorophore, a dimethylene spacer and two different azacrown receptors, are reported. The fluorescence quantum yields and lifetimes of both the systems have been found to be significantly lower than that of the parent fluorophore indicating the occurrence of photoinduced electron transfer (PET) between the terminal moieties. PET is found to be more efficient in II, presumably due to the presence of more than one electron-donating centre in the receptor moiety. Fluorescence decay behaviour of the systems suggests a through-space nature of PET. The systems exhibit off-on fluorescence signalling in the aprotic media in the presence of several metal ions, some of which are well known for their fluorescence quenching abilities. Diazacrown derivative, II, appears to be a somewhat better signalling system than the monoazacrown derivative, I.

  1. Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet

    OpenAIRE

    Pedersen, Natalia; Vegh, Zsuzsanna; Burisch, Johan; Jensen, Lisbeth; Ankersen, Dorit Vedel; Felding, Maria; Andersen, Nynne Nyboe; Munkholm, Pia

    2014-01-01

    In the present study we report on changes in irritable bowel syndrome-severity scoring system (IBS-SSS) and irritable bowel syndrome-quality of life (IBS-QoL) in 19 IBS patients, aged 18 to 74 years (F/M: 14/5), during 12 wk registering their symptoms on the web-application (www.ibs.constant-care.dk). During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention. Thereafter, low fermentable ...

  2. Laschamp and Mono Lake geomagnetic excursions recorded in New Zealand

    Science.gov (United States)

    Cassata, William S.; Singer, Brad S.; Cassidy, John

    2008-04-01

    Eight basaltic lavas from the Auckland volcanic field, New Zealand, record three distinct sets of excursional geomagnetic field directions and low paleointensities, however the timing and therefore paleomagnetic significance of these records have been poorly understood. Radiocarbon, K-Ar, and thermoluminescence dating constrain these lavas to have erupted during the last 75 ka, a period during which as many as three excursions have been recorded differentially at several northern and fewer southern hemisphere sites. Forty 40Ar/ 39Ar incremental heating experiments conducted on groundmass from seven of these excursional lavas indicate that they erupted during at least two periods, at 39.1 ± 4.1 and 31.6 ± 1.8 ka, coincident with 40Ar/ 39Ar, astrochronologic, and 14C ages determined for the Laschamp and Mono Lake excursions, respectively. Samples from a lava flow associated with a third cluster of virtual geomagnetic poles (VGPs) are complicated by low concentrations of radiogenic argon in the presence of excess argon, and thus yield discordant age spectra and an imprecise age of 26.6 ± 8.1 ka. Our findings indicate that the Laschamp and Mono Lake excursions, until recently identified unequivocally and isotopically dated only in the Northern Hemisphere, were globally synchronized at 40 ± 1 and 32 ± 1 ka. However, the VGPs of lavas that record the Laschamp excursion in New Zealand and France are inconsistent with a simple clockwise looping geometry inferred from VGP paths obtained in eight marine sediment cores spanning the Laschamp excursion. We suggest that the differences in VGPs recorded at the various sites are significant and may point to non-axial dipole components and lower mantle control on transitional fields during short-lived excursions.

  3. Collide and Conquer: Constraints on Simplified Dark Matter Models using Mono-X Collider Searches

    CERN Document Server

    Brennan, A J; Gramling, J; Jacques, T D

    2016-01-01

    The use of simplified models as a tool for interpreting dark matter collider searches has become increasingly prevalent, and while early Run II results are beginning to appear, we look to see what further information can be extracted from the Run I dataset. We consider three `standard' simplified models that couple quarks to fermionic singlet dark matter: an $s$-channel vector mediator with vector or axial-vector couplings, and a $t$-channel scalar mediator. Upper limits on the couplings are calculated and compared across three alternate channels, namely mono-jet, mono-$Z$ (leptonic) and mono-$W/Z$ (hadronic). The strongest limits are observed in the mono-jet channel, however the computational simplicity and absence of significant $t$-channel model width effects in the mono-boson channels make these a straightforward and competitive alternative. We also include a comparison with relic density and direct detection constraints.

  4. Gender-Specific Adverse Effects of Mono-ethylhexyl Phthalate on Steroidogenesis in Immature Granulosa Cells and Rat Leydig Cell Progenitors in vitro

    Directory of Open Access Journals (Sweden)

    KonstantinSvechnikov

    2011-04-01

    Full Text Available Di-2-ethylhexyl (DEHP phthalate, one of the phthalates most widely distributed in the environment, causes reproductive toxicity that is attributable to the action of its primary metabolite, mono (2-ethylhexyl phthalate (MEHP. Here, we have investigated the effects of MEHP on steroidogenesis by primary cultures of rat Leydig cell progenitors and immature granulosa cells. This phthalate stimulated basal steroidogenesis and StAR expression in both types of steroidogenic cells. However, when MEHP was incubated with (Bu2cAMP, steroid production was increased in granulosa cells and suppressed in Leydig cell progenitors, a process associated with up-regulation of StAR expression. Our data suggest that MEHP exerts gender-specific adverse effects on the hormonal function of the developing gonads. This may be involved in the development of pathological conditions including disorders of prenatal sex development that may attenuate future reproductive health.

  5. Systematic comparison of the mono-, dimethyl- and trimethyl 3-hydroxy-4(1H)-pyridones - Attempted optimization of the orally active iron chelator, deferiprone.

    Science.gov (United States)

    Xie, Yuan-Yuan; Lu, Zidong; Kong, Xiao-Le; Zhou, Tao; Bansal, Sukhi; Hider, Robert

    2016-06-10

    A range of close analogues of deferiprone have been synthesised. The group includes mono-, di- and tri-methyl-3-hydroxy-4(1H)-pyridones. These compounds were found to possess similar pFe(3+) values to that of deferiprone, with the exception of the 2.5-dimethylated derivatives. Surprisingly the NH-containing hydroxy-4(1H)-pyridones were found to be marginally more lipophilic than the corresponding N-Me containing analogues. This same group are also metabolised less efficiently by Phase 1 hydroxylating enzymes than the corresponding N-Me analogues. As result of this study, three compounds have been identified for further investigation centred on neutropenia and agranulocytosis. PMID:27014847

  6. La lunga attesa di Marsis

    Directory of Open Access Journals (Sweden)

    Fabrizio Bernardini

    2005-10-01

    Full Text Available Abbiamo parlato in altre occasioni di MARSIS e della sua progenie SHARAD, due esperimenti italiani per la misura di caratteristiche sottosuperficiali del pianeta Marte. Prodotti innovativi ed unici che nascondono un potenziale scientifico elevato. La strada per Marte però non è così facile come può sembrare e se la realizzazione degli strumenti non è stata esente da dolori, l’interpretazione e la divulgazione dei risultati non sono da meno. Le incertezze ed i dubbi sono però ora dissipati: l’esperimento MARSIS funziona perfettamente e per la prima volta nella storia dell’umanità abbiamo uno strumento e gli elementi per capire cosa c’è nel sottosuolo di un altro pianeta, senza aver inviato sul posto geologi ne’ tantomeno squadre per movimenti di terra.

  7. Gaya Busana Harajaku Di Jepang

    OpenAIRE

    Simanjuntak, Elisa

    2016-01-01

    Harajuku adalah sebutan populer untuk kawasan di sekitar Stasiun JR Harajuku, Distrik Shibuya, Tokyo. Kawasan ini terkenal sebagai tempat anak-anak muda berkumpul. Lokasinya mencakup sekitar Meiji Jingū, Taman Yoyogi, pusat perbelanjaan Jalan Takeshita (Takeshita-dōri), departement store Laforet, dan Gimnasium Nasional Yoyogi. Di sana akan dijumpai berbagai macam gaya, mulai dari tokoh kartun, gaya seorang punk rock dengan segala pernak-pernik besi sebagai asesoris, gothic dengan ciri khas pa...

  8. Di(hydroxyphenyl)- benzimidazole monomers

    Science.gov (United States)

    Connell, John W. (Inventor); Hergenrother, Paul M. (Inventor); Smith, Joseph G. (Inventor)

    1993-01-01

    Di(hydroxyphenyl)benzimidazole monomers were prepared from phenyl-hydroxybenzoate and aromatic bis(o-diamine)s. These monomers were used in the synthesis of soluble polybenzimidazoles. The reaction involved the aromatic nucleophilic displacement of various di(hydroxyphenyl)benzimidazole monomers with activated aromatic dihalides or activated aromatic dinitro compounds in the presence of an alkali metal base. These polymers exhibited lower glass transition temperatures, improved solubility, and better compression moldability over their commercial counterparts.

  9. ADAPTASI PETANI DI KALIMANTAN SELATAN

    OpenAIRE

    - Wahyu

    2013-01-01

    Tujuan penelitian ini adalah untuk mengkaji antropologi transmigrasi, terutama tentang kemampuan adaptif transmigran di lokasi baru. Banyak transmigran  datang dari daerah dengan latar belakang budaya dan alam yang berbeda-beda, ada yang dari daerah pegunungan, daerah sulit air, maupun daerah irigasi. Penelitian ini menganalisis tiga variabel: budaya (tradisi),  motivasi, dan kemampuan dasar petani, yang diperkirakan memiliki hubungan dekat dengan kemampuan adaptif di lokasi yang baru.  Me...

  10. Profil Merokok pada Pelajar di Tiga SMP di Kota Padang

    Directory of Open Access Journals (Sweden)

    Yessy Susanti Sabti

    2015-09-01

    Full Text Available Abstrak   Merokok merupakan kontributor utama kematian.  Jumlah perokok semakin meningkat di seluruh dunia dan sebagian besar berada dinegara berkembang, termasuk Indonesia. Sebagai negara dengan perokok terbanyak ketiga di dunia, prevalensi perokok remaja di Indonesia semakin meningkat setiap tahun. Dengan menggunakan kuesionerGlobal Youth Tobacco Survey, kami meneliti profil merokok pada pelajar di tida SMP di kota Padang. Desain peneitian adalah crossectional. Data diperoleh dari kuesioner Global Youth Tobacco Survey, berbahasa Indonesia. Didapatkan sampel 240  murid dari 3 SMP dipilih secara acak di Kota Padang. Hasil : 27,7% murid pernah merokok, dan semuanya adalah laki-laki. 29%  mencoba rokok pada usia kurang dari 10 tahun. 37%  murid masih merokok sampai sekarang, 46% diantaranya sudah ketagihan rokok. Sebanyak 77,1% murid yang pernah merokok mempunyai orang tua perokok. Sebagian besar dari total sampel terpapar asap rokok lingkungan baik di rumah dan di tempat-tempat umum. Kesimpulan: Lebih dari seperempat pelajar di tiga SMP di kota Padang pernah merokok dan semuanya laki laki, dan mencoba merokok padausia kurang dari 10 tahun. Hampir seperlima sudah ketagihan merokok.Kata kunci: Pelajar, Merokok, Global Youth Tobacco SurveyAbstract Smoking is the mayor contibutor of death, and the number of smoker is growing overworld. More of them live in the developing country, including Indonesia. As the third of most smoker number, the teenager smoker prevalence in Indonesia is increase over year. By using Indonesian language adapted of Global Youth Tobacco Survey quessionaires, we researched smoking teenager behaviour and realted factors at Junior High School of Padang. Design of study is crossectional, datas collected from 240 students of three randomized selected Junior High School, by  Global Youth Tobacco Survey quessionaires that has adapted to Indonesian language. Results : 27,7% of students reported that they ever smoked cigarettes

  11. ATLANTE ON-LINE DI GEOGRAFIA: FACILITAZIONE DI TESTI

    Directory of Open Access Journals (Sweden)

    Cristina Baccella

    2015-02-01

    Full Text Available Al centro di questo lavoro vi è la proposta di un intervento di facilitazione su un testo di geografia contenuto nell'Atlante online Unimondo, un sito che si rivolge a studenti delle scuole primarie e secondarie. Obiettivo di questo lavoro è individuare quelle che sono in generale le criticità dei testi disciplinari e gli ostacoli che essi pongono dinnanzi a uno studente straniero (e non solo, proponendo in seguito alcuni interventi didattici mirati ad accompagnare il discente nella comprensione del testo e nello sviluppo della lingua dello studio. Dopo aver presentato brevemente le due opzioni della semplificazione e della facilitazione e aver fatto alcune considerazioni sulla preferibilità dell’una piuttosto che dell’altra, si è preso in esame il testo in questione. Ad una dettagliata analisi linguistica delle principali difficoltà ivi contenute, segue la proposta di un percorso di facilitazione mediante attività tese a permettere allo studente un approccio di successo con il testo autentico. Obiettivo della proposta è presentare un modello applicabile ad altri testi dello stesso tipo, mirato allo sviluppo da parte dello studente di una sempre maggiore consapevolezza circa i propri processi cognitivi e le strategie di lettura che può mettere in atto, puntando verso una sempre maggiore autonomia.   Online Geography Atlas: facilitation of texts This paper focuses on the proposal to facilitate use of a geography text contained in the online Unimondo Atlas. This site caters to primary and secondary school students. This paper aims to identify the critical aspects of disciplinary texts and the obstacles they pose to foreign students (and not only, proposing some educational interventions aimed at accompanying the student in understanding the text and in developing the language of study. After a brief presentation of two ways to simplify and facilitate the materials, and a discussion of how one or the other might be preferable, we

  12. EGNOS: è ora di usarlo

    Directory of Open Access Journals (Sweden)

    Fabrizio Bernardini

    2006-04-01

    Full Text Available Dall’inizio di quest’anno EGNOS, European Geostationary Navigation Overlay Service, iniziativa dell’Unione Europea e dell’Agenzia Spaziale Europea, è operativo e nel corso dell’anno raggiungerà i livelli di servizio richiesti dapprima per le applicazioni commerciali e, all’inizio del 2007, quelli per le applicazioni Safety Of Life. Sarà dunque il conseguimento finale di EGNOS V2.1 al quale farà seguito un programma di evoluzione articolato in tre altre fasi che si estenderanno almeno fino alla fine del 2011 con ampliamenti della copertura, della fornitura di servizi anche nella nuovabanda L5, fino all’integrazione con Galileo. In questo articolo,che gode della collaborazione della Next SpA, realizzatriceanche dell’applicazione descritta nella rubrica Reports di questo stesso numero, vogliamo evidenziare alcuni aspetti del sistema che non ci sembra ancora ben apprezzato a livello utente e due prospettive note come SISNET ed ESA ALIVE.

  13. Conoscenze e comportamenti in relazione alla prevenzione delle malattie neoplastiche in un gruppo di studenti di scuola media superiore della provincia di Milano

    OpenAIRE

    P. Giametta; M.C. Gandini; V. Garretto; P. Aletti; P. Bulgheroni; Bulgheroni, A.

    2003-01-01

    Obiettivi: valutare il livello di conoscenza ed i comportamenti a rischio per neoplasie maligne in un gruppo di studenti di scuola media superiore allo scopo di definire la necessità di interventi di informazione/ educazione sanitaria tesi alla prevenzione di tali patologie.

    Metodi: un apposito questionario, anonimo ed a risposte chiuse, è stato somminstrato a studenti delle classi III° e IV° di un Liceo Scie...

  14. Modellazione Tridimensionale del Processo di Combustione di un Razzo a Propellente Solido

    OpenAIRE

    Bertacin, Roberto

    2013-01-01

    La regolazione dei sistemi di propulsione a razzo a propellente solido (Solid Rocket Motors) ha da sempre rappresentato una delle principali problematiche legate a questa tipologia di motori. L’assenza di un qualsiasi genere di controllo diretto del processo di combustione del grano solido, fa si che la previsione della balistica interna rappresenti da sempre il principale strumento utilizzato sia per definire in fase di progetto la configurazione ottimale del motore, sia per analizzare le e...

  15. Studio e realizzazione di sistemi di percezione frontale per autoveicoli mediante visione artificiale

    OpenAIRE

    Caraffi, Claudio

    2008-01-01

    In questa tesi saranno presentati i sistemi di percezione frontale a 3 telecamere in posizione asimmetrica dei veicoli autonomi TerraMax e TerraMax2 che hanno partecipato alle edizioni 2004 e 2005 della DARPA Grand Challenge e 2007 della DARPA Urban Challenge, con la descrizione degli algoritmi utilizzati per la calibrazione di telecamere, la stabilizzazione di immagini, l'estrazione di corsie stradali, la rilevazione di pendenza e l'individuazione di ostacoli in ambiente off-road. ...

  16. Valutazione di composti bioattivi ad attività antiossidante in alimenti di origine vegetale

    OpenAIRE

    Mignogna, Rossella

    2011-01-01

    Negli alimenti di origine vegetale sono naturalmente presenti alcuni composti bioattivi, cioè composti aventi o no valore nutrizionale e dotati di attività biologica che si esplica nel ridurre il rischio di sviluppo di numerose malattie croniche, svolgendo, quindi, una fondamentale azione protettiva sulla nostra salute. All’interno di questo gruppo di composti si inseriscono gli antiossidanti, definiti come sostanze che, in basse concentrazioni rispetto al substrato ossidabile e sotto specifi...

  17. Bovine Induced Pluripotent Stem Cells Are More Resistant to Apoptosis than Testicular Cells in Response to Mono-(2-ethylhexyl Phthalate

    Directory of Open Access Journals (Sweden)

    Ying-Chu Lin

    2014-03-01

    Full Text Available Although the androgen receptor (AR has been implicated in the promotion of apoptosis in testicular cells (TSCs, the molecular pathway underlying AR-mediated apoptosis and its sensitivity to environmental hormones in TSCs and induced pluripotent stem cells (iPSCs remain unclear. We generated the iPSCs from bovine TSCs via the electroporation of OCT4. The established iPSCs were supplemented with leukemia inhibitory factor and bone morphogenetic protein 4 to maintain and stabilize the expression of stemness genes and their pluripotency. Apoptosis signaling was assessed after exposure to mono-(2-ethylhexyl phthalate (MEHP, the active metabolite of di-(2-ethylhexyl phthalate. Here, we report that iPSCs were more resistant to MEHP-induced apoptosis than were original TSCs. MEHP also repressed the expression of AR and inactivated WNT signaling, and then led to the commitment of cells to apoptosis via the cyclin dependent kinase inhibitor p21CIP1. The loss of the frizzed receptor 7 and the gain of p21CIP were responsible for the stimulatory effect of MEHP on AR-mediated apoptosis. Our results suggest that testicular iPSCs can be used to study the signaling pathways involved in the response to environmental disruptors, and to assess the toxicity of environmental endocrine disruptors in terms of the maintenance of stemness and pluripotency.

  18. Preparazione di derivati azotati di bifenili di origine naturale da utilizzare come leganti per siti nicotinici

    OpenAIRE

    Piras, Stefania; Azzena, Ugo Gavino; Finà, Clara; Delogu, Giovanna

    2006-01-01

    I recettori nicotinici sono canali ionici attivati da un legante e costituiscono le molecole chiave che mediano la trasmissione tra un neurone e l’altro attraverso l’acetilcolina. Essi sono coinvolti nella malattia dell’Alzheimer, pertanto, al fine di contrastare gli effetti della patologia, si somministrano al malato farmaci che aumentano la produzione di acetilcolina, sostanza che, a sua volta, potenzia i recettori nicotinici. Si pensa, inoltre, che questi recettori possano a...

  19. Su Lectura Dantis di Carmelo Bene (con un’apparizione di Salvatore Sciarrino)

    OpenAIRE

    Caputo, Simone

    2015-01-01

    L’indagine propone una disamina di Lectura Dantis, lavoro di Carmelo Bene del 1981, alla luce delle riflessioni elaborate da Vincenzo Caporaletti sul Principio audiotattile e utilizzate in questo caso di studio per un primo avvicinamento al teatro “sonoro” di Carmelo Bene. L’idea di affrontare Lectura Dantis dal versante della musica e non da quello del teatro deriva dalla lettura di due scritti dedicati a Bene: Antropologia di una macchina attoriale di Piergiorgio Giacchè e Un muezzin per Da...

  20. Un processo di ingegneria inversa sulla cuspide in selce di Tabina 1

    Directory of Open Access Journals (Sweden)

    Vittorio Brizzi

    2006-06-01

    Full Text Available Nell’insieme delle punte di freccia ritrovate nelle terramare padano-venete, la cuspide di Tabina 11 (proveniente dallo scavo della terramare di Tabina di Magreta - Modena è di foggia particolare. Per le sue dimensioni fisiche e per la sua morfologia il manufatto rappresenta un esempio di specializzazione atipico nelle Culture mediterranee dell’età del Bronzo, e può dare informazioni sul possibile sistema balistico in grado di scagliarla. Per la sua massa, le sue dimensioni e la sua forma si può ipotizzare che si tratti di una cuspide destinata ad una freccia per la caccia, utilizzabile da un arco efficiente e forte.

  1. L'amicizia negli scritti di Aelredo di Rievaulx. Una conoscenza puntiforme

    Directory of Open Access Journals (Sweden)

    Lorenzo Braca

    2010-06-01

    Full Text Available L'amicizia, per il cistercense inglese Aelredo di Rievaulx (1110-1167, rappresenta il principale veicolo di conoscenza divina: la fusione dello spirito di due amici è il primo gradino di una scala di perfezione che conduce all'unione con Dio. Secondo alcuni storici, però, alla base della sua teologia starebbe il bisogno di canalizzare una mal sofferta pulsione sessuale. Questo articolo analizza la teologia di Aelredo come dottrina della conoscenza raggiunta attraverso l'amore e discute la possibilità di trovare nei suoi scritti segni del suo orientamento sessuale.

  2. Ghiande Missili Iscritte di età Ellenistica Nella Collezione Privata di Berna Oğuz di Izmir (Turchia)

    OpenAIRE

    Laflı, Ergün; Buora, Maurizio

    2016-01-01

    Si pubblicano qui otto ghiande missili con iscrizioni in greco della collezione di Berna Oǧuz di Izmir (Turchia), databili al IV secolo alla tarda età ellenistica (forse II-I secolo a.C.). Si aggiunge una ghianda del museo di Izmir con iscrizione in latino, di epoca romana. Si dà quindi notizia dell’esistenza di altre ghiande nei musei di Ödemiş, Akhisar e Balikesir. The paper presents eight slingshots with greek inscriptions belonging to the collection of Berna Oǧuz, Izmir (Tu...

  3. Diasporici metropolitani: nuovi scenari quotidiani di lotta di classe

    Directory of Open Access Journals (Sweden)

    Sergio Straface

    2009-04-01

    Full Text Available Uno dei concetti su cui mi piace riflettere è quello della velocità. Più precisamente se sia possibile connettere l’intelligenza alla velocità. Oggi è necessario essere veloci e il vivere velocemente ha conquistato la quotidianità confondendosi strategicamente con la nozione di intelligenza. Le coordinate della surmodernità: l’accelerazione della storia, il restringimento dello spazio e l’individualizzazione dei destini pare abbiano imposto la velocità come conditio sine qua non sia improbabile conquistare un dignitoso ruolo sociale. Velocità come chiave di accesso, password obbligatoria, condizione connettiva con cui l’io finalmente accede all’attuale e soprattutto intelligente modo di vivere. La mia riflessione si concentrerà sull’esempio di lentezza proposto dai barboni, da ora in poi definiti diasporici metropolitani. Velocità vs lentezza, dunque, per una riflessione sulle contemporanee dinamiche del vivere metropolitano. Mi soffermerò su sensazioni, emozioni, ricordi e principalmente dubbi, per articolare una prima critica dell’equazione normativa “velocità uguale intelligenza” nonché per mostrare un esempio di resistenza, un modello altro in opposizione da quello dominate.

  4. GAMBARAN PRAKTIK PENGGUNAAN JAMU OLEH DOKTER DI ENAM PROVINSI DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Delima Delima

    2013-02-01

    Full Text Available Abstract Herbal medicine has been widely used. Government supports become more obvious since the declaration of “Saintifikasi Jamu” in Januari 2010 in Kendal, Central Java. To obtain this program, inventory of herbal medicine usage by physicians was conducted. This was a cross sectional descriptive study in 6 provinces of Java and Bali. Doctors registered as member of herbal medicine related association were invited and asked to fill a set of structured questionnaire. A total of 108 physicians using Indonesian herbal medicine participated in this study. They were either general practitioners or specialists with median age of 43 (range 26-70 years old. They (76.9% have used herbal medicine for 1-10 years with median of  2 patients per day (range 0-40. The physicians also practiced other traditional medicines such as acupuncture (47.2 %, massage (7.4 %, acupressure (6.5%. Besides prescribing herbal medicine to their patients, all physicians also consumed herbal medicine for themselves and their family. They used mainly with mono or combined herb in capsule and simplicia. Mostly herbal medicine were given to hypertension, dyslipidemia, diabetes mellitus, acute upper respiratory disease, hepatitis, hyperuricemia, osteoarthritis, diarrhea, cancer, and gastritis. Curcuma xanthorrhiza, Andrographis paniculata, Curcuma domestica (turmeric, Centella asiatica, Orthosiphon aristatus, Apium graveolens (celery, Phylanthus niruri, Guazuma ulmifolia, Zingiber officinale, and Curcuma zedoaria were prescribed. As conclusion, most of the herbal physician in Java and Bali prescribed Indonesian herbal medicine in this 10 years periode combined with foreign herbal medicine and other traditional medicines but still using conventional medicine as the highest standard of theraphy. Key words: herbal medicine, Saintifikasi Jamu, traditional medicine AbstrakPemanfaatan jamu telah berkembang luas. Dukungan pemerintahpun semakin jelas sejak dicanangkannya Saintifikasi

  5. Proposal of development of an advanced IORT system; Proposta di sviluppo di un sistema IORT di avanguardia

    Energy Technology Data Exchange (ETDEWEB)

    Ronsivalle, C. [ENEA, Centro Ricerche Frascati, Rome (Italy). Unita tecnico scientifica Tecnologie Fisiche Avanzate; Casali, F. [Bologna Univ., Bologna (Italy), Dipartimento di fisica; Colavita, E. [Calabria Univ., Arcavacata (Italy). Diparimento di fisica; Lamanna, E. [Magna Graecia Univ., Germaneto (Italy). Dipartimento di medicina sperimentale e clinica

    2005-07-15

    In the last years there has been an increasing interest on IORT (Intraoperative Radiation Therapy), also because of the development of dedicated accelerators. This technique represents a very effective oncological treatment consisting in delivering a single high dose on a tumour bed soon after surgery resection. In the following we present the proposal of development of a last generation IORT system based on the use of a linear accelerator with variable energy in the range 3-15 MeV, operating in C band (5712 MHz). Respect to the accelerator used in the commercial IORT systems operating at a typical frequency of 2998 MHz (S band) limited to a maximum energy of 12 MeV, the use of a higher RF frequency allows an increase of the maximum energy. This extends the use of the IORT technique to a wider field of tumors and an improvement of the system in terms of compactness and weight reduction. In addition the machine will be provided with a devoted absolute dosimetry system that will strongly simplify the procedures of dosimetric characterization. We intend to develop the system by a collaboration between ENEA, some Universities (Bologna, Catanzaro and Cosenza) and the national industry. [Italian] Negli ultimi anni si e sviluppato un sempre maggior interesse intorno alla Radioterapia IntraOperatoria (IORT), una particolare tecnica radioterapica che permette di irradiare la zona interessata da un tumore durante un intervento chirurgico utilizzando un fascio di elettroni prodotto da un acceleratore. La diffusione di questa metodica e stata favorita dalla presenza sul mercato di acceleratori installabili direttamente in sala operatoria. Come conseguenza di questa disponibilita sono emerse sia nuove esigenze legate alle particolari applicazioni cliniche, sia richieste di facilita di utilizzo e perfomances sempre piu sofisticate. Viene qui presentata una proposta di sviluppo di un sistema IORT di ultima generazione basato sull'utilizzo di un acceleratore lineare con

  6. Trasforiiazioni Termoelastiche Finite di Solidi Incomprimibili

    Science.gov (United States)

    Signorini, A.

    Queste lezlioni hanno come direttiva una sintesi di quanto si trova sistematicamente sviluppato in una mia Memoria sulle trasformazioni termoelastiche finite di solidi incomprimibili, in corso di stampa negli Annali di Matematica pura e applicata t. XXXIX ( 1955) pp. 147-201 , Verranno anche esposti, come necessaria premessa, alcuni d ei risultati di due precedenti Memorie degli stessi Annali. Invece, per motivo di brevità, non potrò dare neppure un cenno delle ulteriori ricerche svilup pate dal prof. T. Manacorda in tre recentissimi suoi lavori:

  7. Pressioni antropiche all’interno di un sito Natura 2000: linee di indirizzo e monitoraggio delle attività di messa in sicurezza di emergenza nel sito di interesse nazionale di Orbetello

    OpenAIRE

    Gabellini, M.; A. AUSILI; Mumelter, E.; Trama, V.; Girardi, R.; Trinchera, G.; Barbara, W.; de Propris, L.; Onorati, F; Tornato, A.; Cappucci, S.; S. Russo(Lugano); F. Giovanardi

    2007-01-01

    L’elevato valore naturalistico e socioeconomico di un Sito Natura 2000 richiede che tutte le attività antropiche che si svolgono al suo interno (es. pesca, turismo, trasporti, attività industriali, etc.) siano gestite in maniera tale da non pregiudicare le specie e gli habitat per i quali l’area è stata designata. Molti di questi Siti sono ambienti di transizione, ovvero zone che costituiscono il passaggio naturale tra terra e mare. La loro posizione di interfaccia ...

  8. Studio di prototipo di calorimetro per neutroni per l'esperimento ALICE

    CERN Document Server

    Arnaldi, R; Cicalò, C; Cortese, P; De Falco, A; Dellacasa, G; De Marco, N; Gallio, M; Macciotta, P; Masoni, A; Musso, A; Oppedisano, C; Piccotti, A; Puddu, G; Scomparin, E; Siddi, S; Serci, E; Soave, C; Usai, G L; Vercellin, Ermanno

    1999-01-01

    ALICE e uno dei quattro esperimenti previsti ad LHC, al CERN, il cui scopo e lo studio delle osservabili che danno informazioni rilevanti sulla formazione del quark gluon plasma, che potrebbe essere prodotto in collisioni centrali Pb-Pb, di energia nel centro di massa di 5.5 A TeV.Il parametro di impatto di tali collisioni verra determinato grazie ad un insieme di calorimetri per protoni e neutroni che misureranno l'energia portata in avanti dai nucleoni non interagenti(spettatori).E' stato costruito un prototipo di calometro per neutroni, formato da piani di fibre di quarzo, posti a 45 gradi rispetto all'asse del fascio e inframmezzati da piani di materiale passivo denso(tungsteno). La luce Cerenkov prodotta nelle fibre dallo sciame sviluppato nel materiale passivo,viene raccolta da guide ottiche in aria.Verranno presentati i rilustati di un test previsto al CERN SPS per il luglio 1999.

  9. Sirio Giannini, Prati di fieno e I racconti

    Directory of Open Access Journals (Sweden)

    Arianna Gianotti

    2010-06-01

    Full Text Available Recensiamo i due volumi di Sirio Giannini, Prati di fieno, con Prefazione di Daniela Marcheschi, e I racconti, con Prefazione di Paolo Capovani, Edizioni Polistampa, Firenze, 2010.

  10. High pressure behaviour of heavy rare earth mono antimonides

    International Nuclear Information System (INIS)

    We have investigated theoretically the high-pressure structural phase transition and cohesive properties of two heavy rare earth mono antimonides (RESb; RE = Dy and Lu) by using two body interionic potential with necessary modifications to include the effect of Coulomb screening by the delocalized 4f electrons of the RE ion. The peculiar properties of these compounds have been interpreted in terms of the hybridization of f electrons with the conduction band and strong mixing of f states of RE ion with the p orbital of neighboring pnictogen ion. These compounds exhibit first order crystallographic phase transition from their NaCl (B1) phase to CsCl (B2) phase at 23.6 GPa and 25.4 GPa respectively. The bulk modulii of RESb compounds are obtained from the P-V curve fitted by the Birch equation of state. We also calculated the RE-RE distance as a function of pressure. Elastic properties of these compounds have also been studied and their second order elastic constants are calculated.

  11. Adding Mono- and Multivalent Ions to Lyotropic Chromonic Liquid Crystals

    Science.gov (United States)

    Tortora, Luana; Park, Heung-Shik; Antion, Kelly; Woolwerton, Chris; Finotello, Daniele; Lavrentovich, Oleg

    2006-03-01

    Lyotropic Chromonic Liquid Crystals (LCLCs) are a distinct class of liquid crystals formed in aqueous solutions by molecules with rigid polyaromatic cores and ionic groups at the periphery [1-4]. The phase diagrams of these materials should depend on entropic factors (as in the Onsager model) and electrostatic interactions. Using optical polarizing microscopy, we studied the effects of mono- and multivalent ions on the phase diagrams of Blue 27 [3] and Sunset Yellow [2]. The monovalent ions change the temperatures of phase transitions, as described in [4], while the effect of multivalent ions is more dramatic and, in addition to the changed temperatures of phase transitions by tens of degrees, it often involves condensation of LCLC aggregates into domains with birefringence much higher than that in a normal nematic phase. Work supported by OBR B-7844. [1]J. Lydon, Current Opin. Colloid & Interface Sci. 3, 458 (1998);8, 480-489 (2004); [2]V. R. Horowitz, L. A. Janowitz, A. L. Modic, P. J. Heiney, and P. J. Collings, 2005, Phys. Rew. E 72, 041710; [3]Yu. A. Nastishin, H. Liu, T. Schneider, T., V. Nazarenko, R. Vasyuta, S. V. Shiyanovskii, and O. D. Lavrentovich, 2005, Phys. Rev. E 72, 041711; [4]A.F. Kostko, B. H. Cipriano, O. A. Pinchuk, L. Ziserman, M. A. Anisimov, D. Danino, and S. R. Raghavan. J. Phys. Chem. B 109, 19126-19133 (2005)

  12. THE RECOGNITION OF SPOKEN MONO-MORPHEMIC COMPOUNDS IN CHINESE

    Directory of Open Access Journals (Sweden)

    Yu-da Lai

    2012-12-01

    Full Text Available This paper explores the auditory lexical access of mono-morphemic compounds in Chinese as a way of understanding the role of orthography in the recognition of spoken words. In traditional Chinese linguistics, a compound is a word written with two or more characters whether or not they are morphemic. A monomorphemic compound may either be a binding word, written with characters that only appear in this one word, or a non-binding word, written with characters that are chosen for their pronunciation but that also appear in other words. Our goal was to determine if this purely orthographic difference affects auditory lexical access by conducting a series of four experiments with materials matched by whole-word frequency, syllable frequency, cross-syllable predictability, cohort size, and acoustic duration, but differing in binding. An auditory lexical decision task (LDT found an orthographic effect: binding words were recognized more quickly than non-binding words. However, this effect disappeared in an auditory repetition and in a visual LDT with the same materials, implying that the orthographic effect during auditory lexical access was localized to the decision component and involved the influence of cross-character predictability without the activation of orthographic representations. This claim was further confirmed by overall faster recognition of spoken binding words in a cross-modal LDT with different types of visual interference. The theoretical and practical consequences of these findings are discussed.

  13. On the mono-exponential fitting of phosphorescence decays

    Science.gov (United States)

    Fuhrmann, N.; Brübach, J.; Dreizler, A.

    2014-08-01

    Several methods for mono-exponential fitting of decay curves are presented and compared among each other in terms of precision, accuracy and computational time. Simulated noisy data sets are generated and evaluated in order to determine the main contributors to a loss in performance. The influence of the temporal discretization of the decay curve on the precision of the fitting methods is discussed. Correlations between the background offset and the decay time are analyzed. Variations of the signal-to-noise ratio are shown, allowing for evaluation of systematic errors and precision in the presence of noise. Finally, the algorithms are applied to experimental data, and the computational efforts for the different algorithms are compared. The results of this latter investigation confirm the conclusions drawn from the simulated data and the following conclusions are drawn: The frequently applied method of performing a linear regression to the logarithm of a background-corrected decay showed systematic errors in the presence of noise. Best results in terms of precision and accuracy were obtained by a nonlinear least-squares approximation and a method denoted as the linear regression of the sum. Additionally, this latter method required the lowest computational time and is finally recommended for determining decay times from experimental data.

  14. Antioxidant and cytotoxic activity of mono- and bissalicylic acid derivatives

    Directory of Open Access Journals (Sweden)

    Đurendić Evgenija A.

    2014-01-01

    Full Text Available A simple synthesis of mono- and bis-salicylic acid derivatives 1-10 by the transesterification of methyl salicylate (methyl 2-hydroxybenzoate with 3-oxapentane-1,5-diol, 3,6- dioxaoctane-1,8-diol, 3,6,9-trioxaundecane-1,11-diol, propane-1,2-diol or 1-aminopropan- 2-ol in alkaline conditions is reported. All compounds were tested in vitro on three malignant cell lines (MCF-7, MDA-MB-231, PC-3 and one non-tumor cell line (MRC- 5. Strong cytotoxicity against prostate PC-3 cancer cells expressed compounds 3, 4, 6, 9 and 10, all with the IC50 less than 10 μmol/L, which were 11-27 times higher than the cytotoxicity of antitumor drug doxorubicin. All tested compounds were not toxic against the non-tumor MRC-5 cell line. Antioxidant activity of the synthesized derivatives was also evaluated. Compounds 2, 5 and 8 were better OH radical scavengers than commercial antioxidants BHT and BHA. The synthesized compounds showed satisfactory scavenger activity, which was studied by QSAR modeling. A good correlation between the experimental variables IC50 DPPH and IC50 OH and MTI (molecular topological indices molecular descriptors and CAA (accessible Connolly solvent surface area for the new compounds 1, 3, and 5 was observed.

  15. Determination of mono ethanolamine by non-suppressed ion chromatography

    International Nuclear Information System (INIS)

    Mono ethanol amine (MEA) is world wide used as all volatile treatment agent to maintain alkaline pH in the entire steam water circuit of nuclear power station. Spectrophotometric method of MEA analysis suffers from interference in presence of hydrazine which is used as oxygen scavenger. A simple, rapid, accurate and quantitative determination of monoethanolamine (MEA) in coolant water was accomplished by cation exchange chromatography with conductometric detection in non-suppressed mode. A Metrosep cation 1-2 analytical column connecting with a Metrosep cartridge was used for cation separation. A solution containing a mixture of 4 mM tartaric acid, 1 mM dipicolinic acid, 20% acetone and 0.05 mM HNO3 was used as eluent. The limit of detection for MEA was 0.1 μg ml-1 and relative standard deviation was 2% for the overall method. The method was applied for the determination of MEA in steam generator water sample without any interference of hydrazine. The recovery was in the range of 95-102%. (author)

  16. The microbial arsenic cycle in Mono Lake, California.

    Science.gov (United States)

    Oremland, Ronald S; Stolz, John F; Hollibaugh, James T

    2004-04-01

    Significant concentrations of dissolved inorganic arsenic can be found in the waters of a number of lakes located in the western USA and in other water bodies around the world. These lakes are often situated in arid, volcanic terrain. The highest concentrations of arsenic occur in hypersaline, closed basin soda lakes and their remnant brines. Although arsenic is a well-known toxicant to eukaryotes and prokaryotes alike, some prokaryotes have evolved biochemical mechanisms to exploit arsenic oxyanions (i.e., arsenate and arsenite); they can use them either as an electron acceptor for anaerobic respiration (arsenate), or as an electron donor (arsenite) to support chemoautotrophic fixation of CO(2) into cell carbon. Unlike in freshwater or marine ecosystems, these processes may assume quantitative significance with respect to the carbon cycle in arsenic-rich soda lakes. For the past several years our research has focused on the occurrence and biogeochemical manifestations of these processes in Mono Lake, a particularly arsenic-rich environment. Herein we review some of our findings concerning the biogeochemical arsenic cycle in this lake, with the hope that it may broaden the understanding of the influence of microorganisms upon the speciation of arsenic in more common, less "extreme" environments, such as drinking water aquifers. PMID:19712427

  17. Mono-THF ring annonaceous acetogenins from Annona squamosa.

    Science.gov (United States)

    Hopp, D C; Alali, F Q; Gu, Z M; McLaughlin, J L

    1998-03-01

    Continuing work on the bark of Annona squamosa Rich. (Annonaceae), directed by the brine shrimp lethality test (BST), has resulted in the isolation of three new Annonaceous acetogenins, 4-deoxyannoreticuin, cis-4-deoxyannoreticuin, and (2,4-cis and trans)-squamoxinone. The first two are additional examples of acetogenins isolated from this plant species which contain the unusual feature of an oxygen functionality at the C-9 position. They have a hydroxylated mono-THF ring with respective threo/trans/threo and threo/cis/threo relative stereochemistries. The latter compound is a ketolactone mixture which has the same relative stereochemistry around the THF ring and the same spatial relationship between the THF ring and the hydroxyl group along the aliphatic chain as 4-deoxyannoreticuin, but is two methylene units longer. Additionally, the isolated hydroxyl group is at C-11, while the THF ring starts at C-17, instead of at C-9 and C-15, respectively, as for the first two compounds. All three compounds showed moderate, but significant, cytotoxicities against a panel of six human tumor cell lines with (2,4 cis and trans)-squamoxinone showing promising selectivity against the pancreatic cell line (PACA-2). PMID:9542173

  18. Elementi di management dei programmi spaziali

    CERN Document Server

    Spagnulo, Marcello

    2012-01-01

    La realizzazione e il lancio nello spazio di satelliti o sonde attraverso missili o navette spaziali sono un esempio di attività industriale di enorme complessità e di lungo periodo. Lo sviluppo di un programma spaziale prevede la realizzazione di vari sistemi costituenti: il segmento spaziale, cioè i lanciatori per l’accesso allo Spazio, i satelliti o le sonde, le infrastrutture spaziali abitate da astronauti oppure robotizzate; e il segmento di terra che consente agli operatori sulla terra di controllare i sistemi nello spazio e di fruire delle applicazioni derivanti dal loro uso. Il settore è di per sé peculiare dato l’ambiente extra-atmosferico ove si troveranno ad operare astronauti o sonde robotizzate, pertanto la manifattura dei sistemi spaziali è una pratica a metà strada tra la scienza esatta e l’artigianato di elevatissima qualità. Le metodologie e i processi realizzativi dei programmi spaziali hanno però avuto il pregio nel passato di costituire, sin dagli anni ’60, un modello di r...

  19. Sviluppo di uno strumento per la rivelazione tridimensionale delle inclusioni di tellurio in cristalli di CZT e CdTe

    OpenAIRE

    Zambelli, Nicola

    2010-01-01

    Nell'ultimo decennio si e' osservato un notevole miglioramento nella capacita' di eseguire spettroscopia a dispersione di energia, sia relativamente alla rilevazione di raggi X e che a quella delle particelle, cariche e non. Molteplici sono ormai gli ambiti in cui queste tecnologie trovano applicazione, dal campo medicodiagnostico all'astrofisica, passando dal monitoraggio dei processi industriali al settore della sicurezza aeroportuale e ambientale. Di fondamentale importanza in questo proce...

  20. Incontro di lavoro sul tema : Sicurezza Informatica

    OpenAIRE

    Carlesi, Carlo

    2003-01-01

    L'incontro di lavoro sul tema sicurezza informatica ? stato organizzato con l'intento di: Promuovere la sensibilizzazione alla cultura della sicurezza informatica; Evidenziare i diversi aspetti della sicurezza informatica; Presentare alcune soluzioni/prodotti commerciali .

  1. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessme...

  2. Developing C# Apps for iPhone and iPad using MonoTouch

    CERN Document Server

    Costanich, Bryan

    2011-01-01

    Developing C# Applications for iPhone and iPad using MonoTouch shows you how to use your existing C# skills to write apps for the iPhone and iPad. Fortunately, there's MonoTouch, Novell's .NET library that allows C# developers to write C# code that executes in iOS. Furthermore, MonoTouch allows you to address all the unique functions of the iPhone, iPod Touch, and iPad. And the big plus: You needn't learn any Objective-C to master MonoTouch!. Former Microsoft engineer and published app-store developer Bryan Costanich shows you how to use the tools you already know to create native apps in iOS

  3. Valutazione della sostenibilità ambientale tramite metodologia LCA di sistemi per lo sfruttamento di fonti alternative di energia e materiali

    OpenAIRE

    Chiavetta, Cristian

    2013-01-01

    La dissertazione ha riguardato l’analisi di sostenibilità di un sistema agronomico per la produzione di olio vegetale a fini energetici in terreni resi marginali dall’infestazione di nematodi. Il processo indagato ha previsto il sovescio di una coltura con proprietà biofumiganti (brassicacea) coltivata in precessione alla specie oleosa (soia e tabacco) al fine di contrastare il proliferare dell’infestazione nel terreno. Tale sistema agronomico è stato confrontato attraverso una analisi di cic...

  4. 15th Incontri di Fisica delle Alte Energie

    CERN Document Server

    2016-01-01

    La XV Edizione di IFAE - Incontri di Fisica delle Alte Energie - si terrà presso il Dipartimento di Fisica dell'Università di Genova L'edizione 2016 comprenderà numerose sessioni dedicate alla discussione degli aspetti di maggiore interesse attuale e di prospettiva nella fisica delle alte energie.

  5. La costruzione ideologica dell’identità martiriale: i Quaranta martiri di Sebaste, Teodoro di Amasea e Stefano Protomartire negli encomi di Gregorio di Nissa

    OpenAIRE

    Chiriatti, Mattia C.

    2013-01-01

    L’esaltazione del martirio si sviluppa parallelamente alla costruzione ideologica dell’identità cristiana, attraverso la teorizzazione del sacrificio come pilastro del Cristianesimo primitivo. La morte cruenta rivela, nel discepolato cristiano, il vincolo indissolubile esistente tra vita e identità religiosa. Come si evince dagli encomi di Gregorio di Nissa, esiste una relazione intrinseca tra la letteratura martiriale e il forgiarsi di un’identità cristiana. Per il vescovo di Nissa, il model...

  6. Concorso di progettazione Piazza Verdi - La Spezia

    OpenAIRE

    Vitone, Luca; Boehm, Frank

    2016-01-01

    Il progetto, realizzato insieme all’architetto e curatore Frank Boehm, è presentato nel 2009 nell’ambito del concorso di progettazione per la riqualificazione architettonica e artistica di Piazza Giuseppe Verdi bandito dal Comune di La Spezia e P.A.A.L.M.A. (Premio Artista Architetto La Marrana Arte Ambientale) in collaborazione con la Fondazione Cassa di Risparmio della Spezia. Artista e architetto immaginano una soluzione che trasformi la piazza in zona pedonale e in un “salotto urbano”...

  7. Principi generali di gestione della manutenzione

    CERN Document Server

    Furlanetto, Luciano; Macchi, Marco

    2006-01-01

    In questo volume vengono fornite le premesse per il superamento della tradizionale visione della manutenzione, quale inevitabile accidente e costo da ridurre, a favore di un'immagine culturale innovativa in cui la manutenzione consente un superamento del modello consumistico delle sostituzioni verso una ecosostenibilità del patrimonio di impianti e infrastrutture. Sulla base di queste premesse, ci si rivolge a manager, imprese, studiosi e studenti del campo dei servizi di manuntenzione.

  8. Marcel Proust, Sentimenti filiali di un matricida

    OpenAIRE

    Stefano Ballerio

    2011-01-01

    Pubblicato sul «Figaro» dell’1 febbraio 1907 e poi nel volume dei Pastiches et melanges del 1919, Sentiments filiaux d’un parricide racconta la tragica fine di Henri van Blarenberghe, esponente dell’alta borghesia parigina e conoscente di Proust, che in un accesso di follia uccise la madre per poi suicidarsi. Si propongono una nuova traduzione italiana dell’articolo – con il finale che contro la volontà di Proust fu omesso nell’edizione s...

  9. I Nutrienti: molecole di signalling cellulare

    OpenAIRE

    P. Palestini

    2014-01-01

    Una corretta nutrizione costituisce un fattore imprescindibile per il raggiungimento dello stato di salute L’alterazione dell’equilibrio nutrizionale, nel senso di un eccesso o un difetto, conduce infatti inevitabilmente a uno stato di malnutrizione con conseguenze anche molto gravi sullo stato di salute stesso. In questo senso, la dietetica svolge un compito indispensabile soprattutto attraverso l’educazione nutrizionale, un intervento che, oggi, dovrebbe essere necessariamente rivolt...

  10. Analisi sperimentale e simulazione numerica dell’efficienza di strutture di ritenuta per il contenimento delle colate detritiche.

    OpenAIRE

    Canelli, Luigi

    2013-01-01

    In questo lavoro è stata indagata e analizzata l’efficienza degli interventi di tipo strutturale con particolare attenzione alle briglie selettive realizzate in funi di acciaio. La progettazione di queste strutture non è soggetta a specifica normativa nel caso di fenomeni di colata e, al momento, sono poche le evidenze scientifiche che garantiscono l’installazione e l’utilizzo di questo tipo di barriere con adeguati fattori di sicurezza. Questa incertezza non è legata alle caratteristiche mec...

  11. Geothermal systems of the Mono Basin-Long Valley region, eastern California and western Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Higgins, C.T.; Flynn, T.; Chapman, R.H.; Trexler, D.T.; Chase, G.R.; Bacon, C.F.; Ghusn, G. Jr.

    1985-01-01

    The region that includes Mono Basin, Long Valley, the Bridgeport-Bodie Hills area, and Aurora, in eastern California and western Nevada was studied to determine the possible causes and interactions of the geothermal anomalies in the Mono Basin-Long Valley region as a whole. A special goal of the study was to locate possible shallow bodies of magma and to determine their influence on the hydrothermal systems in the region. (ACR)

  12. Mono-chlorophenol degradation by pseudomonas putida CP1 and a mixed microbial population

    OpenAIRE

    Farrell, Alan

    2000-01-01

    A commercial mixed culture, Biolyte HAB, degraded mono-chlorophenols using a metci- cleavage pathway. 2- and 3-chlorophenol degradation was incomplete, leading to the accumulation of dead-end metabolites. Biolyte HAB was capable of the complete degradation of 2.34 mM 4-chlorophenol, via the intermediate 5-chloro-2- hydroxymuconic semialdehyde, using the meta- cleavage pathway. Pseudomonas putida CPI degraded mono-chlorophenols to completion via an orthocleavage pathway. The ability of P. ...

  13. Stochastic resonance in a mono-stable system with multiplicative and additive noise

    International Nuclear Information System (INIS)

    The stochastic resonance in a biased mono-stable system subject to multiplicative and additive noise is investigated. Based on the adiabatic approximation theory, the analytic expression of the signal-to-noise ratio (SNR) is obtained. It is shown that the SNR is a non-monotonic function of the intensities of the multiplicative and additive noise, as well as the parameters of the mono-stable system

  14. Implementasi Secure Hash Algorithm (SHA) Dan Substitusi Mono Alfabet Dalam Sistem Pengamanan Data

    OpenAIRE

    Raja Salomo Tarigan

    2009-01-01

    Penggunaan data digital dalam dunia sekarang ini sudah meliputi hampir semua aspek. Salah satu upaya pengamanan data digital yang dapat dilakukan adalah kriptografi. Teknik kriptografi klasik seperti Substitusi Mono Alphabet tidak pernah digunakan lagi karena tidak dapat menyaingi kompleksitas teknik kriptografi yang lain oleh karena kesederhanaannya. Oleh karena itu timbul suatu gagasan untuk menggunakan kembali algoritma kriptografi klasik seperti Substitusi Mono Alphabet dengan cara mengga...

  15. Proses Pembuatan Mono-Digliserida (MDG) dari Refined Bleached Deodorized Palm Oil (RBDPO) Secara Gliserolisis Enzimatis

    OpenAIRE

    Zakwan

    2016-01-01

    ZAKWAN. The Catalyzed Enzymatic Glycerolysis Process of Refined Bleached Deodorized Palm Oil for the Mono-diglyceride Synthesis. Supervised Elisa Julianti and Zulkifli Lubis. Indonesia is one of the largest palm oil producing countries in the world and the production is still increasing; therefore, product diversifications should be done to obtain higher added value to Indonesia. One of the potential products is palm based emulsifier. Mono-diglyceride (MDG) is the mostly used emulsifier in...

  16. Nitrogen-containing derivatives of mono terpenoids: approaches to the synthesis and prospects for usage

    International Nuclear Information System (INIS)

    The article generalizes the research devoted to obtaining, structure and properties of nitrogen-containing derivatives of mono terpenoids from plant essential oils. The information on usage of amination reagents and catalysts is presented. Biological activity versus molecular structure dependence of nitrogen-containing derivatives of mono terpenoids is characterized.The structure of the new obtained compounds has been determined by physical-chemical methods (IR, 13C NMR spectroscopy, X-ray analysis)

  17. Studio delle prestazioni di giunzioni incollate ibride

    Directory of Open Access Journals (Sweden)

    F.Moroni

    2011-01-01

    Full Text Available Le giunzioni ibride sono giunzioni in cui coesistono due differenti tipologie di giunzione, di cui una è l’incollaggio. L’articolo mostra i risultati di una campagna sperimentale volta a caratterizzare le prestazioni di giunti incollati ibridi in confronto ad alcune tipologie di giunzioni tradizionali. Si sono prese in considerazioni come tecnologie di giunzione tradizionali la saldatura a resistenza, la rivettatura a strappo, la clinciatura e la rivettatura auto perforante. In particolare si sono studiate le prestazioni di giunti a semplice sovrapposizione per differenti condizioni geometriche del giunto (spessore aderendi, passo tra i punti di fissaggio meccanico e condizioni ambientali (temperatura di esercizio, presenza o meno di invecchiamento. La pianificazione della campagna sperimentale, e la successiva analisi dei risultati sono state svolte mediante Design of Experiments.I risultati dei test mostrano che le giunzioni ibride conducono ad significativo un miglioramento delle prestazioni quando le due tecnologie di giunzione componenti il giunto ibrido hanno prestazioni simili, mentre forniscono prestazioni pari o inferiori a quelle delle giunzione più resistente quando vengono accoppiate tecnologie di giunzione con prestazioni molto differenti.

  18. Convegni: rapporti di ricerca o relazioni tecniche?

    OpenAIRE

    Renzo Carlucci

    2009-01-01

    Se da un lato viene spontaneo sentirsi colpiti dalla restrizione operata ai fondi, dall'altro non si può fingere di ignorare lo spreco di risorse del sistema italiano per la ricerca che, seppur avanzato nella sua dualità accademica e istituzionale, si trova attualmente in una fase di profonda decadenza.

  19. Convegni: rapporti di ricerca o relazioni tecniche?

    Directory of Open Access Journals (Sweden)

    Renzo Carlucci

    2009-03-01

    Full Text Available Se da un lato viene spontaneo sentirsi colpiti dalla restrizione operata ai fondi, dall'altro non si può fingere di ignorare lo spreco di risorse del sistema italiano per la ricerca che, seppur avanzato nella sua dualità accademica e istituzionale, si trova attualmente in una fase di profonda decadenza.

  20. Le narrazioni come metodo di indagine sociologica

    Directory of Open Access Journals (Sweden)

    Rita Bichi

    2012-04-01

    Full Text Available L'incontro trentino ha dimostrato l'interesse crescente dei giovani sociologi per lo sviluppo dei metodi narrativi e la capacità che questi hanno di essere efficaci nell'analisi di svariati temi, dai racconti di malattia alle narrazioni identitarie, dallo studio di lavoro e organizzazioni a quello delle migrazioni, di genere e memoria. Tuttavia, l'interesse della sociologia italiana va visto in un quadro di sviluppo più ampio a livello europeo e americano dove, a partire dagli anni '90, l'intervento di alcuni autori come Lyotard, Bruner e Macintyre, ha sancito quella che alcuni autori hanno definito svolta narrativa. La sociologia, infatti, tende sempre più a valorizzare la narrazione come processo di conoscenza peculiare che è attivato costantemente nella vita quotidiana; la "rivoluzione" risiede nel fatto che la narrazione diventa oggetto della sociologia e la disciplina stessa valorizza il suo uso sia come strumento di indagine scientifica, sia come modo di conoscere che come modo di comunicare, rivendicando la legittimità scientifica all'ascolto della parola diretta degli individui coinvolti all'interno delle ricerche di stampo sociologico.

  1. La ragione flessibile di Giovanni Bottiroli

    Directory of Open Access Journals (Sweden)

    Elio Franzini

    2013-12-01

    Full Text Available Recensione a Giovanni Bottiroli, La ragione flessibile. Modi d’essere e stili di pensiero. Torino: Bollati Boringhieri, 2013. Sulla possibilità di una «logica della flessibilità» (Bottiroli ovvero di una «logica che segua la vita» (Franzini. 

  2. Good quality blastocyst from non-/mono-pronuclear zygote may be used for transfer during IVF.

    Science.gov (United States)

    Yin, Bao-Li; Hao, Hao-Ying; Zhang, Ya-Nan; Wei, Duo; Zhang, Cui-Lian

    2016-04-01

    Although healthy infants have developed from non- and mono-pronuclear zygotes, the transfer of embryos from non- and mono-pronuclear zygotes is not recommended because there are no proper selection criteria. In the present study, we discuss how to select non- and mono-pronuclear embryos with the highest developmental potential at 19-20 hours post-insemination. We found that the percentage of blastocysts with normal chromosome constitution in non-pronuclear zygotes was slightly higher than in mono-pronuclear zygotes. Non- and mono-pronuclear embryos that were at the 4-cell stage on D2 and/or at the 6- to 8-cell stage on D3 had higher incidence rates of blastocysts with normal chromosome constitutions. We also found higher incidences of blastocysts with normal chromosome constitution on D6 than on D5. The results suggest that if high quality non- and mono-pronuclear zygotes develop to the 4-cell stage on D2 and the 6-to 8- cell stages on D3, along with high quality D6 blastocysts, the incidence of blastocysts with normal chromosome constitution is higher. PMID:26901373

  3. The biosynthesis of allelopathic di-C-glycosylflavones from the roots of Desmodium incanum (G. Mey.) DC.

    Science.gov (United States)

    Hao, Bing; Caulfield, John C; Hamilton, Mary L; Pickett, John A; Midega, Charles A O; Khan, Zeyaur R; Wang, Junru R; Hooper, Antony M

    2015-12-28

    The allelopathic root exudate of the drought-tolerant subsistence cereal intercrop D. incanum, protecting against the parasitic weed Striga hermonthica, comprises a number of di-C-glycosylflavones specifically containing C-glucosyl, C-galactosyl and C-arabinosyl moieties. Here we demonstrate that the biosynthesis of all compounds containing a C-glucose involves C-glucosylation of 2-hydroxynaringenin with subsequent C-galactosylation, C-glucosylation or C-arabinosylation. In addition, the crude soluble enzyme extract converts two fluorinated 2-hydroxyflavanone analogues to corresponding mono- and di-C-glycosylflavones demonstrating that some differences in C-ring substitution can be tolerated by the plant enzymes. Elucidating the biosynthesis of these C-glycosylflavones (CGFs) has the potential to open up opportunities for transferring the enzymic and genetic basis for the S. hermonthica inhibiting allelopathic trait to food crop plants. PMID:26478440

  4. Mono- and multistatic polarimetric sparse aperture 3D SAR imaging

    Science.gov (United States)

    DeGraaf, Stuart; Twigg, Charles; Phillips, Louis

    2008-04-01

    SAR imaging at low center frequencies (UHF and L-band) offers advantages over imaging at more conventional (X-band) frequencies, including foliage penetration for target detection and scene segmentation based on polarimetric coherency. However, bandwidths typically available at these center frequencies are small, affording poor resolution. By exploiting extreme spatial diversity (partial hemispheric k-space coverage) and nonlinear bandwidth extrapolation/interpolation methods such as Least-Squares SuperResolution (LSSR) and Least-Squares CLEAN (LSCLEAN), one can achieve resolutions that are commensurate with the carrier frequency (λ/4) rather than the bandwidth (c/2B). Furthermore, extreme angle diversity affords complete coverage of a target's backscatter, and a correspondingly more literal image. To realize these benefits, however, one must image the scene in 3-D; otherwise layover-induced misregistration compromises the coherent summation that yields improved resolution. Practically, one is limited to very sparse elevation apertures, i.e. a small number of circular passes. Here we demonstrate that both LSSR and LSCLEAN can reduce considerably the sidelobe and alias artifacts caused by these sparse elevation apertures. Further, we illustrate how a hypothetical multi-static geometry consisting of six vertical real-aperture receive apertures, combined with a single circular transmit aperture provide effective, though sparse and unusual, 3-D k-space support. Forward scattering captured by this geometry reveals horizontal scattering surfaces that are missed in monostatic backscattering geometries. This paper illustrates results based on LucernHammer UHF and L-band mono- and multi-static simulations of a backhoe.

  5. Discovery and industrial applications of lytic polysaccharide mono-oxygenases.

    Science.gov (United States)

    Johansen, Katja S

    2016-02-15

    The recent discovery of copper-dependent lytic polysaccharide mono-oxygenases (LPMOs) has opened up a vast area of research covering several fields of application. The biotech company Novozymes A/S holds patents on the use of these enzymes for the conversion of steam-pre-treated plant residues such as straw to free sugars. These patents predate the correct classification of LPMOs and the striking synergistic effect of fungal LPMOs when combined with canonical cellulases was discovered when fractions of fungal secretomes were evaluated in industrially relevant enzyme performance assays. Today, LPMOs are a central component in the Cellic CTec enzyme products which are used in several large-scale plants for the industrial production of lignocellulosic ethanol. LPMOs are characterized by an N-terminal histidine residue which, together with an internal histidine and a tyrosine residue, co-ordinates a single copper atom in a so-called histidine brace. The mechanism by which oxygen binds to the reduced copper atom has been reported and the general mechanism of copper-oxygen-mediated activation of carbon is being investigated in the light of these discoveries. LPMOs are widespread in both the fungal and the bacterial kingdoms, although the range of action of these enzymes remains to be elucidated. However, based on the high abundance of LPMOs expressed by microbes involved in the decomposition of organic matter, the importance of LPMOs in the natural carbon-cycle is predicted to be significant. In addition, it has been suggested that LPMOs play a role in the pathology of infectious diseases such as cholera and to thus be relevant in the field of medicine. PMID:26862199

  6. OVERVIEW OF MONO-ENERGETIC GAMMA-RAY SOURCES & APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Hartemann, F V; Albert, F; Anderson, G G; Anderson, S G; Bayramian, A J; Betts, S M; Chu, T S; Cross, R R; Ebbers, C A; Fisher, S E; Gibson, D J; Ladran, A S; Marsh, R A; Messerly, M J; O' Neill, K L; Semenov, V A; Shverdin, M Y; Siders, C W; McNabb, D P; Barty, C P; Vlieks, A E; Jongewaard, E N; Tantawi, S G; Raubenheimer, T O

    2010-05-18

    Recent progress in accelerator physics and laser technology have enabled the development of a new class of tunable gamma-ray light sources based on Compton scattering between a high-brightness, relativistic electron beam and a high intensity laser pulse produced via chirped-pulse amplification (CPA). A precision, tunable Mono-Energetic Gamma-ray (MEGa-ray) source driven by a compact, high-gradient X-band linac is currently under development and construction at LLNL. High-brightness, relativistic electron bunches produced by an X-band linac designed in collaboration with SLAC NAL will interact with a Joule-class, 10 ps, diode-pumped CPA laser pulse to generate tunable {gamma}-rays in the 0.5-2.5 MeV photon energy range via Compton scattering. This MEGa-ray source will be used to excite nuclear resonance fluorescence in various isotopes. Applications include homeland security, stockpile science and surveillance, nuclear fuel assay, and waste imaging and assay. The source design, key parameters, and current status are presented, along with important applications, including nuclear resonance fluorescence. In conclusion, we have optimized the design of a high brightness Compton scattering gamma-ray source, specifically designed for NRF applications. Two different parameters sets have been considered: one where the number of photons scattered in a single shot reaches approximately 7.5 x 10{sup 8}, with a focal spot size around 8 {micro}m; in the second set, the spectral brightness is optimized by using a 20 {micro}m spot size, with 0.2% relative bandwidth.

  7. Analisi della risposta sismica di un edificio campione nel Comune di Ariano Irpino (AV)

    OpenAIRE

    Cogliano, R.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Di Giulio, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Fodarella, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Improta, L.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Minichiello, V.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Pucillo, S.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Riccio, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Rovelli, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia

    2006-01-01

    Nella pratica ingegneristica vengono usate correlazioni derivate da regressioni statistiche tra numero dei piani degli edifici e frequenze di risonanza. Tuttavia la discrepanza tra comportamento reale e valori aspettati può essere talvolta significativa, e solo l’acquisizione di dati sperimentali consente di comprendere il reale comportamento dinamico di una struttura. La sperimentazione, in situazioni anche complesse, e la raccolta di nuovi dati possono essere molto importanti nel campo dell...

  8. Analisi numerica del comportamento strutturale di solai alveolari in presenza di aperture

    OpenAIRE

    Garutti, Nicola

    2013-01-01

    L’argomento della tesi riguarda lo studio del comportamento strutturale di particolari elementi precompressi prefabbricati in conglomerato armato, ovvero i pannelli alveolari. Lo studio condotto si propone, nello specifico, di analizzare attraverso simulazioni numeriche agli elementi finiti la risposta strutturale, in regime di non linearità del materiale, di una porzione significativa di solaio in cui siano praticate aperture caratterizzate da dimensioni e posizione variabili. La finalità ul...

  9. Tecnica di densificazione attraverso la strategia delle centralità urbane di tipo metropolitano.

    OpenAIRE

    Strina, Paolo

    2015-01-01

    La tesi adotta e sperimenta la tecnica di densificazione attraverso la strategia delle centralità all’interno di contesti urbani di medie dimensioni. Il campo di analisi applicata prescelto è composto dalle dieci città capoluogo di provincia della Regione Emilia Romagna. Il carattere dominante delle città contemporanee, riscontrabile anche nelle città emiliano-romagnole, è la dispersione della forma. Lo sviluppo diffuso della città contemporanea è stato alimentato nell’ultimo ventennio da...

  10. I diritti di quarta generazione. il decreto ‘salva alcoa’: un esempio di diritto fluido

    OpenAIRE

    Foschini, Federica

    2012-01-01

    Nell’ambito del Diritto dell’Energia si è potuto assistere alla nascita di molti diritti di quarta generazione ex novo o come specificazioni di diritti già esistenti. Infatti, nonostante la cospicua legislazione in materia, le principali tematiche connesse al diritto dell’energia nascono prima di tutto da esigenze sociali. Ciò conduce all’analisi di due temi fondamentali: il dualismo tra fonti legislative e valori/interessi sociali e il ruolo attivo della giurisprudenza....

  11. Meccanismi di risposta di simbionti lichenici allo stress foto-ossidativo

    OpenAIRE

    Candotto Carniel, Fabio

    2014-01-01

    I licheni, una simbiosi mutualistica tra un fungo (il micobionte), generalmente un ascomicete, e una o più popolazioni di alghe e/o cianobatteri (il fotobionte) sono considerati forme di vita estremofile in quanto da disidratati possono resistere a condizioni ambientali molto difficili come elevati irraggiamenti solari, scarsa disponibilità d'acqua e di nutrienti e dosi elevate di inquinanti aerodiffusi. Tali fattori di stress tuttavia inducono una sovrapproduzione a livello cellulare d...

  12. Studio degli effetti funzionali e tossici di derivati di Brassicaceae in modelli sperimentali

    OpenAIRE

    Melega, Simone

    2013-01-01

    I vegetali appartenenti alla famiglia delle Brassicaceae, sono ricchi di molecole biologicamente attive note per le numerose proprietà salutari. L’effetto di un estratto di germogli di cavolo nero toscano (TBCSE) è stato investigato, in termini chemiopreventivi, sugli enzimi epatici del metabolismo degli xenobiotici e antiossidanti, in ratti trattati con TBCSE. I risultati hanno mostrato un complesso pattern di modulazione, con una prevalente inibizione, del sistema citocromo P450-dipendente,...

  13. Caratterizzazione del legame di molecole di interesse farmaceutico alla sieroalbumina umana mediante biocromatografia e dicroismo circolare

    OpenAIRE

    Pistolozzi, Marco

    2008-01-01

    Negli ultimi anni, un crescente numero di studiosi ha focalizzato la propria attenzione sullo sviluppo di strategie che permettessero di caratterizzare le proprietà ADMET dei farmaci in via di sviluppo, il più rapidamente possibile. Questa tendenza origina dalla consapevolezza che circa la metà dei farmaci in via di sviluppo non viene commercializzato perché ha carenze nelle caratteristiche ADME, e che almeno la metà delle molecole che riescono ad essere commercializzate, ha...

  14. Un evento catastrofico: una sfida per l'attivazione di strutture di conoscenza e di azione

    Directory of Open Access Journals (Sweden)

    Bisi Roberta

    2015-03-01

    Full Text Available L’articolo analizza, partendo dalle relazioni di consulenza tecnica di ufficio medico-legale e psichiatrica, il percorso biografico e la rappresentazione della condannata AMF. Un’attenzione particolare viene rivolta ad alcuni degli strumenti psicodiagnostici utilizzati per delineare il profilo di personalità di AMF e, di conseguenza, l’impegno volto a valorizzare ed affermare la dignità dei sentimenti e delle relazioni affettive, utili per ridare senso alla propria appartenenza sociale, nel tentativo di conciliare le ragioni del cuore e le passioni della ragione. À partir du rapport d’expertise médico-légale et psychiatrique, l’article analyse le récit de vie d’AMF et la représentation de soi. Une attention particulière est portée à certaines méthodes psychodiagnostiques utilisées pour établir le profil de la personnalité d’AMF dans le but de mettre en valeur et d’affirmer la dignité des sentiments et des relations affectives. Ces dernières s’avèrent utiles pour redonner sens à son appartenance sociale en cherchant à concilier les raisons du coeur et les passions de la raison. On the basis of the technical consulting reports concerning the psychiatric clinical forensic examination, the article analyses AMF's biographic background and her self-representation. A special attention is paid to some of the psychodiagnostic tools used to outline the personality profile of AMF and as a consequence it is taken into consideration the responsibility to appraise and state the dignity of the emotional feelings and the family bonds necessary to give meaning to the individual social identity in the attempt to conciliate the reasons of the heart and the passions of the reason.

  15. La logistica nei processi di trasformazione dell’area orientale di Napoli

    Directory of Open Access Journals (Sweden)

    Adriana Galderisi

    2010-07-01

    Full Text Available Stoccaggio e trasporto merci hanno assunto, già da alcuni anni, un ruolo rilevante nell’area orientale di Napoli, con impatti significativi sulla qualità urbana ed ambientale dell’area. In quest’area, anche grazie alla sua vicinanza ai principali nodi della mobilità (porto, aeroporto, stazione ferroviaria e alla significativa presenza di aree produttive dismesse o in dismissione, trovano oggi spazio numerose attività di stoccaggio e spedizione merci, in molti casi localizzate all’interno di ex aree industriali, in assenza di una reale ottica “sistemica”. Pertanto, a partire da una breve disamina dell’evoluzione dell’area orientale e di quanto previsto dagli strumenti urbanistici vigenti per la sua trasformazione, il contributo focalizza l’attenzione sul ruolo attuale dslle attività di stoccaggio e trasporto merci nell’area. Quindi, sulla base di alcune recenti esperienze di italiane e in riferimento ad ipotesi già avanzate per l’organizzazione di una piattaforma logistica nell’area orientale di Napoli -quale strumento per ottimizzare le necessità di stoccaggio e trasporto merci riducendone le esternalità negative- valuta la compatibilità di tali scelte con le prospettive di evoluzione/trasformazione dell’area e il potenziale ruolo che l’area potrebbe svolgere in una prospettiva di ri-organizzazione del trasporto merci in ambito urbano.

  16. Antropologi dan Jaringannya di Indonesia

    OpenAIRE

    Jonris G. Purba

    2009-01-01

    Jika melihat tulisan ini sepintas dari judulnya, maka kita akan bertanya mengapa antropologi mempunyai jaringan. Di samping itu kita juga akan bertanya: jaringan seperti apa yang ada dalam antropologi itu? Bagaimana terbentuknya jaringan itu? Dan apa yang menjadi latar belakang munculnya jaringan antropologi tersebut? Serta apa saja manfaat dan kegiatan yang dilaksanakan dalam jaringan tersebut? ker-jul2006- (3)

  17. "Ho voglia di te." Proposta di traduzione in islandese, con analisi, di un brano tratto dal romanzo di Federico Moccia

    OpenAIRE

    Hanna Lára Kristjánsdóttir 1983

    2010-01-01

    Þýðing á hluta úr "Ho voglia di te" sem er unglingabók eftir Federico Moccia. Í ritgerðinni koma fram nokkrar helstu kenningar í þýðingafræði ásamt umfjöllun um helstu vandamálin sem komu fram við þýðinguna.

  18. Transisi Demografi di Indonesia; Seabad ?

    Directory of Open Access Journals (Sweden)

    Dr. Kemal N. Siregar

    2012-09-01

    Full Text Available Transisi demografi adalah proses perubahan kematian dan kelahiran yang berlangsung dari tingkatan yang tinggi ke tingkatan yang rendah dalam suatu kurun waktu pada masyarakat tertentu. Transisi ini muncul dengan terjadinya banyak perubahan di masyarakat, diantaranya adalah perubahan sosio-ekonomi yang berhubungan timbal balik dengan kesehatan.

  19. Dati di traffico telefonico e politiche urbane

    Directory of Open Access Journals (Sweden)

    Paola Pucci

    2013-11-01

    Full Text Available Il paper propone una riflessione sulle possibilità offerte dai dati di traffico telefonico nel fornire conoscenze utili a costruire politiche per la mobilità più efficaci ed eque. A partire dai risultati di una esperienza di ricerca avviata presso il Dastu Politecnico di Milano sulla significatività dei dati di traffico telefonico di Telecom Italia nel restituire le densità d’uso del territorio (Manfredini, Pucci & Tagliolato, 2012 e 2013 e le origini e destinazioni dei movimenti giornalieri di mobilità (Tagliolato, Manfredini & Pucci, 2013, si evidenziano le potenzialità analitiche e interpretative offerte da questi dati nel descrivere le modalità con cui differenti popolazioni urbane usano il territorio e le possibili ricadute sulle politiche per la mobilità.Nella ricerca condotta, il trattamento dei dati di traffico telefonico ha consentito di restituire la variabilità spazio-temporale delle pratiche d’uso in Lombardia, a partire dalle quali si sono individuati “comunità di pratiche” e “territori contingenti”, generati cioè dalle pratiche di diverse popolazioni temporanee, che si sono assunti come perimetri utili per una diversa articolazione delle competenze e distribuzione delle risorse disponibili. Nel paper l’individuazione di popolazioni urbane temporanee attraverso i dati di traffico telefonico non ha unicamente una finalità interpretativa, ma rappresenta la condizione attraverso cui riconoscere le nuove domande disaggregate per “comunità di pratiche”, su cui costruire politiche di offerta più efficaci e meno onerose finanziariamente, poiché non generaliste.

  20. Il contributo di una Unitá Operativa Complessa: di Infettivologia Pediatrica durante l'epidemia di morbillo in Campania.

    Directory of Open Access Journals (Sweden)

    G. De Lorenzo

    2003-05-01

    Full Text Available

    Il morbillo è un importante problema di Sanità Pubblica che comporta un elevato rischio di complicanze con conseguenti eccessi di ospedalizzazione, mortalità e costi elevati.

    Obiettivi: Valutare incidenza, decorso clinico, complicanze e scelte terapeutiche in bambini ospedalizzati per morbillo, nonché l’impatto dell’epidemia su strutture ed operatori di una U.O.C. di Infettivologia Pediatrica con 16 p.l.

    Metodologia: dalle cartelle cliniche dei bambini ricoverati per morbillo presso l’U.O.C. di Pediatria Infettivologica dell’Ospedale Pausillipon di Napoli, nel corso dell’epidemia verificatasi in Campania tra gennaio e maggio 2002, sono stati raccolti, mediante una apposita griglia di rilevazione, i dati socio anagrafici, quelli relativi a decorso della malattia, eventuali complicanze, scelte terapeutiche adottate, stato immunitario del bambino e della madre, possibile fonte di contagio, motivazione al ricovero. Su 78 bambini ricoverati (38F e 40M, età media di 4,2 anni (range 0,1 14 anni, di cui 20 con età inferiore a 15 mesi, 42 hanno presentato complicanze: 27 broncopolmoniti, di cui 4 di presumibile origine virale e 23 da presumibile sovrainfezione batterica, 7 laringotracheobronchiti (croup, 4 diarrea con disidratazione, 1 otite media, 4 piastrinopenia transitoria, 2 stomatiti, 1 cistite emorragica, 1 meningoencefalite. Oltre alla terapia antibiotica e cortisonica (quando indicate, 27 bambini hanno ricevuto una singola somministrazione di Vitamina A, con decorso favorevole della malattia e nessun effetto collaterale. In soli due bambini era stata praticata la vaccinazione antimorbillo.

    Conclusioni: i dati confermano l’importanza della vaccinazione antimorbillo e l’opportunità di anticiparla a 6 mesi in corso di epidemia (nella quasi totalità dei casi di età ‹15 mesi la fonte di contagio è stata la malattia in

  1. L’identificazione di virus citopatogeni isolati dall’ambiente:ricerca ed applicazione di protocolli analitici

    Directory of Open Access Journals (Sweden)

    A. Carducci

    2003-05-01

    Full Text Available

    Obiettivi: la ricerca dei virus enterici in matrici ambientali, soprattutto nei reflui urbani, risulta di grande interesse sia per la valutazione del rischio di natura virale sia per compiere studi epidemiologici.

    Lo scopo di questo lavoro è stato l’applicazione parallela di diverse tecniche attualmente in uso in virologia clinica a isolati citopatogeni ambientali al fine di ottenere una precisa identificazione degli agenti rilevati.

    Metodi: sono stati analizzati 21 campioni di aerosol, provenienti da impianti di depurazione di reflui civili a fanghi attivi, e risultati citopatogeni in colture di cellule BGM.

    Dopo una nuova semina in “shell vials”, su tre linee cellulari continue per mettere in evidenza eventuali differenze nello spettro di citopatogenicità. Per l’identificazione degli isolati virali, sono state adottate in parallelo: microscopia elettronica, tecniche biomolecolari di amplificazione genica, elettroforesi su gel di poliacrilamide (PAGE, test immunoenzimatici, sieroneutralizzazione.

    Risultati: la semina in “shell vials” ha confermato la
    presenza di particelle virali infettive in tutti i campioni
    tranne uno; inoltre ha permesso di ridurre il
    tempo di comparsa dell’effetto citopatico a 3-4 giorni
    contro i 6-8 giorni necessari seminando in fiasche.
    La microscopia elettronica ha individuato la presenza
    di particelle enterovirus-simili in 18 dei 21
    campioni e di virioni della famiglia Reoviridae in 8.
    La positività dei campioni è stata ottenuta, inoltre,
    con la RT-PCR, per 2 campioni di enterovirus e 2 di
    reovirus e con la PAGE in 6 campioni. Il presente
    studio ha portato ad un’identificazione sufficientemente
    certa di reovirus in 2 campioni e di enterovirus
    in 1 campione.

    Conclusioni: l’identificazione di isolati ambientali si

  2. Radiolytic decontamination of Di-n-butyl phthalate from water

    International Nuclear Information System (INIS)

    Recently, a considerable amount of phthalic acid esters (PAE), the most widely utilized plasticizer, has been released into and polluted the environment. Since their toxicity and teratogenicity, although fairly low, to experimental animals have recently been shown, the removal of them from the environment, especially from the drinking water, is desirable. As an attempt for the removal, the radiolytic degradation of 7-14C-di-n-butyl phthalate (14C-DBP) in water was investigated at several pHs. Approximately 50% of 14C-DBP (1 ppm aqueous solution) was decomposed by 60Co γ-irradiation to a dose of 3 x 104 rad at pH 7 and the main product was mono-n-butyl phthalate (MBP). At pHs 3 and 11 14C-DBP was more easily radiolyzed and converted to ether-soluble compounds other than MBP or phthalic acid (PA). By irradiation to 106 rad 14C-DBP as well as 14C-MBP and 14C-PA, at pH value tested, was almost completely decomposed to volatile or water-soluble substances of possibly low molecular weight. These findings suggest that the γ-irradiation is effective to make the PAE-polluted water clean. (auth.)

  3. Valeria Pala, Tommaso Landolfi traduttore di Gogol’

    Directory of Open Access Journals (Sweden)

    Cinzia Guadalaxara

    2011-04-01

    Full Text Available L’indagine condotta da Valeria Pala sull’opera landolfiana, con particolare riguardo all’attività di traduttore svolta da Landolfi, appare interessante in ogni suo aspetto; fin dalle prime pagine viene posto in rilievo lo stretto legame tra gli scritti di Landolfi e la cultura russa, oggetto di studio dell’autore dagli anni universitari e fonte di perenne ispirazione delle proprie opere. La crisi del sistema culturale italiano,  forte negli anni in cui Landolfi si dedica all’attività di traduttore, induce diversi intellettuali del tempo alla traduzione di testi stranieri, allo scopo di importare nella cultura nazionale elementi mutuati da altri sistemi culturali; la traduzione prende dunque a configurarsi come strumento utile per fornire agli scrittori italiani nuovi modelli su cui improntare la propria produzione poetica e letteraria.

  4. Kinetics of the phthalate metabolites mono-2-ethylhexyl phthalate (MEHP) and mono-n-butyl phthalate (MnBP) in male subjects after a single oral dose.

    Science.gov (United States)

    Mittermeier, Astrid; Völkel, Wolfgang; Fromme, Hermann

    2016-06-11

    Humans have been exposed to dialkyl ortho-phthalates for decades. Due to degradation the phthalate monoesters, responsible for the toxic effects, are additionally found in environmental media as well as food samples. Nevertheless, the toxicokinetic properties of the monoesters are not known. Therefore, metabolism of the phthalate monoesters mono-2-ethylhexyl phthalate (MEHP) and mono-n-butyl phthalate (MnBP) was studied in four male volunteers (23-58 years of age) after ingestion of a single dose of 50μg/kg bw D4-MEHP or 10μg/kg bw D4-MnBP. The main metabolites in urine were determined up to 46h after administration. In the MEHP-study, more than 90% of each metabolite appeared in the urine within the first 22h, and the average excreted amount of D4-MEHP and its four secondary metabolites was 62% of the administered dose. The highest value of 15% was observed for mono-2-ethyl-5-carboxy-pentyl phthalate (D4-5cx-MEPP). The mean elimination half-life of D4-MEHP was estimated to be 3.5±1.4h. In the MnBP-study, the total recovered values of D4-MnBP and its secondary metabolites ranged from 52% to 130%. The monoester itself, with a half-life of 1.9±0.5h, accounted for the majority of the ingested dose (92%), while the secondary metabolites D4-mono-3-hydroxy-n-butyl phthalate (D4-3OH-MnBP) and D4-3-carboxy-mono-propyl phthalate (D4-3cx-MPP) represented only 7.1% and 1.0% of the ingested dose, respectively. Overall, this study determined that the kinetics of the phthalate monoesters MEHP and MnBP after oral dosage are comparable to the properties of their diesters. PMID:27091076

  5. Allacciare i fili spezzati: analisi di tre autobiografie di persone divenute disabili

    Directory of Open Access Journals (Sweden)

    Rosalba Perrotta

    2011-04-01

    Full Text Available Leggere autobiografie consente di conoscere esperienze e momenti della vita che restano ignoti a chi non li ha vissuti. Le autobiografie ci svelano un mondo e, nello stesso tempo, ci introducono in esso. Illustrano e spiegano senza illustrare e senza spiegare. Catturano il lettore nella narrazione e, rendendolo protagonista di quello che accade, gli fanno provare le emozioni di chi racconta e gli mostrano la realtà attraverso i suoi occhi. La corrente sociologica dell’Interazionismo simbolico, un approccio che dà particolare rilievo ai significati attribuiti dagli uomini agli oggetti di cui hanno esperienza, considera le storie di vita uno strumento di indagine prezioso. Il racconto di un tratto della vita, o della vita in genere, consente di raggiungere una conoscenza della realtà soggettiva di chi narra molto superiore rispetto a quella ottenuta attraverso questionari o interviste strutturate.

  6. Homoleptic mono- and dinuclear cationic alkoxydiphosphazane derivatives of rhodium

    International Nuclear Information System (INIS)

    Treatment of the solvento species [Rh(C8H12)(solvent)2][SbF6] (solvent = methanol, ethanol, or tetrahydrofuran) with a twice-molar amount of the diphosphazane ligands (RO)2PN(R') P(OR)2 (R' = Me or Et; R = Me, Et, or Pri) in the appropriate solvent leads to the ready formation of monocationic [Rh{(RO)2PN(R')P(OR)2}2]+ and/or dicationic [Rh2{μ-(RO)2PN(R')P(OR)2}2{(RO)2PN(R')P(OR)2}2]2+ hexafluoroantimonate salts, with the tendency to afford dinuclear derivatives decreasing along the series Me>Et>Pri. Carbon monoxide readily forms addition products with these ionic species, giving rise to five-coordinate derivatives of the type [Rh(CO){(RO)2PN(R')P (OR)2}2][SbF6] in the case of the mononuclear derivatives, and inserting across the two rhodium atoms to afford [Rh2(μ-CO){μ-(MeO)2PN(Et)P(OMe)2}2{(MeO)2PN(Et)P(OMe)2}2][SbF6]2 in the case of [Rh2{μ-(MeO)2PN (Et)P(OMe)2}2{(MeO)2PN(Et)P(OMe)2}2][SbF6]2. These mono- and dicationic derivatives also react readily with iodine affording [RhI2{(RO)2PN(R')P(OR)2}2][SbF6] and [Rh2(μ-I){μ-(MeO)2PN(Et)P(OMe)2}2{(MeO)2 PN(Et)P(OMe)2}2][SbF6]n (n = 2 or 3) respectively. The coordination behaviour of the diphosphorus ligands (MeO)2PCH2P(OMe)2 and Me2PCH2PMe2 towards [Rh(C8 H12)(solvent)2][SbF6] has also been investigated. 1 fig., 1 tab., 19 refs

  7. Il Playground come laboratorio di creatività e inclusione

    OpenAIRE

    Antonio Lauria; Matilde Montalti

    2015-01-01

    In generale, le aree gioco sono luoghi fortemente standardizzati, frutto dell’assemblaggio di attrezzature scelte a catalogo aliene dal contesto di riferimento, povere di stimoli e incapaci di innescare proficue relazioni sociali. Troppo spesso, le attività di gioco sono ripetitive, meccaniche, noiose, contribuiscono in maniera limitata, se non controproducente, allo sviluppo del bambino e alimentano un approccio al gioco povero e passivo. E rara la presenza di opportunità di g...

  8. Recettori per estrogeni e progesterone in tumori mammari di cagna

    OpenAIRE

    Pirino, Salvatore; Sanna, Ennio; Leoni, Antonio; Nieddu, Antonio Mario S.; Antuofermo, Elisabetta; Rocca, Stefano

    2002-01-01

    Con la presente indagine si è inteso: a) verificare l’applicabilità di alcuni monoclonali nell'immunolocalizzazione di recettori per estrogeni e progesterone; b) valutare l’espressine di tali ricettori in differenti tipologie neoplastiche, anche in rapporto con il livello di positività di nuclear antigen (Mib-1); c) sottoporre i risultati a elaborazione statistica allo scopo di verificare la significatività delle medie di espressione e delle correlazioni.

  9. Post Human. Esperienze e questioni di critica d’arte

    OpenAIRE

    Viola, Eugenio

    2010-01-01

    2008 - 2009 Esperienza artistica di confine, luogo di riflessione critica e di aperto dibattito filosofico e antropologico, il Post-Human rappresenta un oggetto teorico estremamente complesso, ricco di prospettive e di molteplici sviluppi. Una costellazione di pratiche e di proposte critiche che, maturata nell’ultimo decennio del Novecento, continua a segnare i percorsi dell’arte e della critica d’arte d’inizio secolo, ponendo questioni che coinvolgono, innanzitutto, le nozi...

  10. I "vincitori in etica": valutazione multicriteriale di fondi socialmente responsabili

    OpenAIRE

    Stefania Funari

    2011-01-01

    A fronte della crescita nellÕofferta di fondi socialmente responsabili che si è registrata nel mercato internazionale nellÕultimo decennio, diviene significativo riuscire a distinguere i diversi fondi etici sulla base dei criteri di responsabilità sociale adottati dai gestori. Per tale motivo recentemente si è iniziato a parlare di rating etico di fondi di investimento, intendendo con tale termine sistemi di classificazione di fondi etici che considerano aspetti legati alla responsabilità soc...

  11. PYDBSCAN UN SOFTWARE PER IL CLUSTERING DI DATI

    OpenAIRE

    Cassisi, C.; UNIVERSITÀ DEGLI STUDI DI CATANIA Dipartimento di Matematica e Informatica; Montalto, P.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Catania, Catania, Italia; Pulvirenti, A.; UNIVERSITÀ DEGLI STUDI DI CATANIA Dipartimento di Matematica e Informatica; Aliotta, M.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Catania, Catania, Italia; Cannata, A.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Catania, Catania, Italia

    2011-01-01

    Con il termine clustering si indica il processo mediante il quale è possibile raggruppare oggetti in base a caratteristiche comuni (features). Questo approccio, alla base dei processi di estrazione di conoscenza da insiemi di dati (data mining), riveste notevole importanza nelle tecniche di analisi. Come verrà mostrato in questo lavoro, l’applicazione delle tecniche di clustering consente di analizzare dataset, con l’obiettivo di ricercare strutture che possano fornire informazion...

  12. Formazione di biofilm e resistenza ai biocidi in Listeria

    OpenAIRE

    MASSA, MARCO

    2011-01-01

    La presente attività di ricerca ha avuto come oggetto di studio la formazione di biofilm in condizioni dinamiche: per raggiungere tale obiettivo, è stato costruito un idoneo apparato che permettesse di ottenere una valutazione quantitativa sia delle cellule presenti nella soluzione di crescita sia di quelle adese su tre materiali di prova(acciaio inossidabile, PET e rame). Oltre ad esprimere una valutazione dell’adesione batterica alle superfici, si è proceduto ad indagare sui possibili ...

  13. Caratterizzazione geotecnica del sottosuolo di San Giuliano di Puglia

    OpenAIRE

    d’Onofrio, A.; Dipartimento di Ingegneria Idraulica, Geotecnica ed Ambientale, Università degli Studi di Napoli “Federico II”, Napoli, Italia; Vitone, C.; Dipartimento di Ingegneria Civile e Ambientale, Politecnico di Bari,Italia; Cotecchia, F.; Dipartimento di Ingegneria Civile e Ambientale, Politecnico di Bari,Italia; Puglia, R.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Milano-Pavia, Milano, Italia; Santucci de Magistris, F.; Laboratorio di Dinamica Strutturale e Geotecnica, StreGa, Università degli Studi del Molise, Temoli (CB), Italia; Silvestri, F.; Dipartimento di Ingegneria Idraulica, Geotecnica ed Ambientale, Università degli Studi di Napoli Federico II, Napoli, Italia

    2009-01-01

    In order to correlate the damages produced by 2002 Molise earthquake to the litostratigraphic and mechanical characteristics of the subsoil, a detailed investigation by in situ and laboratory tests was performed in San Giuliano di Puglia (CB). The investigations were directed both to study the Toppo Capuana marly clays, above which most of the damages of buildings were founds, and, to a lesser extent, the Faeto flysch formation, that is its rigid bedrock. The marly clay deposit is distinguish...

  14. Diazoalkane addition reaction on the fullerene dimer C120O and characterization of the resulting mono-adduct.

    Directory of Open Access Journals (Sweden)

    Uwe Ritter

    2008-06-01

    Full Text Available A mono-adduct of the fullerene dimer C120O was prepared via a diazoalkane addition reaction to obtain rod-like analogue of[60]PCBM opening the possibility to make photovoltaic and photosensitive layers of supra-molecular and anisotropic order.The mono-adduct was obtained as a mixture containing five isomers. The structure of the mono-adduct was verified bymass-, IR-, and 1H-NMR-spectroscopies. The mono-adduct is readily soluble in common fullerene solvents and shows abroader and stronger optical absorption than [60]PCBM. The mono-adduct features a similar acceptor strength as [60]PCBMand [70]PCBM, is stable in air below 150 °C and in nitrogen below 500 °C. The mono-adduct is expected to be a valuablematerial for photovoltaic and photosensitive applications.

  15. Un singolare caso di rifrazione letteraria. A proposito di una generazione di autori di origine russa che scrive nella lingua del paese di adozione

    Directory of Open Access Journals (Sweden)

    Giulia Gigante

    2016-01-01

    Full Text Available Dall’esame di alcuni esempi di contesti narrativi e procedimenti stilistici caratteristici di diversi autori russi contemporanei che hanno scelto di scrivere nella lingua del paese in cui sono emigrati emerge una tendenza comune nella rappresentazione della Russia natia. Pur nella diversità delle loro opere, questi scrittori rappresentano la cultura delle loro radici avvalendosi di una visione ‘caleidoscopica’ in cui i riferimenti storici, letterari, artistici vengono rivisitati attraverso ricordi, sogni e riflessioni e filtrati attraverso la lingua e la cultura della loro terra adottiva.From the investigation of some examples of narrative contexts and stylistic processes typical of various contemporary Russian authors who have chosen to write in the language of the country where they emigrated, a common tendency emerges concerning the representation of Russia. Despite the differences of the works considered, these authors represents the culture of their roots in a ‘kaleidoscopic’ way, reconsidering the historical, literary and artistic references through memories, dreams and reflections, filtering them through the language and culture of their chosen country.

  16. Schede “geologiche” di I e II livello per la “Valutazione degli effetti locali nei siti di ubicazione di singoli edifici (edilizia ordinaria, strategica e monumentale)

    OpenAIRE

    Di Capua, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione AC, Roma, Italia; Peppoloni, S.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione AC, Roma, Italia; Compagnoni, M.; Dipartimento di Ingegneria Strutturale - Politecnico di Milano; Pergalani, F.; Dipartimento di Ingegneria Strutturale - Politecnico di Milano

    2009-01-01

    Nell’ambito di un progetto GNDT del 1999 era stata predisposta una scheda di rilevamento che permetteva una raccolta di informazioni geologiche e geomorfologiche per il sito di ubicazione di un bene monumentale (Di Capua et al, 2005a e 2005b). Questo strumento si è rivelato di grande utilità per il rilievo delle caratteristiche geologiche di sito anche in occasione di eventi sismici recenti. Infatti, è stato utilizzato per raccogliere informazioni preliminari sui siti di ubicaz...

  17. Contenuto vs. contenitore? Criteri predittivi di impatto e soglie di resilienza nella prospettiva del recupero sostenibile

    Directory of Open Access Journals (Sweden)

    Marco Morandotti

    2012-12-01

    Full Text Available Uno dei terreni sul quale si gioca la prospettiva del recupero sostenibile del patrimonio costruito è oggi costituito dalla valorizzazione del patrimonio stesso. Né un approccio intransigentemente refrattario alle istanze di riuso del bene, né quello opposto, orientato al contrario al suo sfruttamento economico, a carico di una troppo gravosa compressione delle stesse esigenze di conservazione, appaiono di fatto perseguibili in una prospettiva di medio periodo. A partire dagli esiti di una ricerca recentemente conclusa, si intende affrontare la questione con una prospettiva organica, in una logica “life cycle oriented”.

  18. Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11β-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells

    International Nuclear Information System (INIS)

    Di-(2-ethylhexyl) phthalate (DEHP) and its metabolite mono-(2-ethylhexyl) phthalate (MEHP) have been classified as toxicants to the reproductive system at the testis level and DEHP may also impair reproductive axis function at the pituitary levels. However, MEHP is 10-fold more potent than DEHP in toxicity and little is known about the toxicological effect of MEHP on pituitary. In this study, we demonstrated that 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), not 11β-HSD1, is strongly expressed in murine gonadotrope LβT2 cells. Interestingly, MEHP inhibited Hsd11b2 mRNA level and 11β-HSD2 enzyme activity in LβT2 cells at as low as 10-7 M. Corticosterone (CORT) at a concentration of 10-6 M significantly inhibited LβT2 cell proliferation after 2-day culture, and 10-6 M RU486, an antagonist of glucocorticoid receptor (GR), reversed this inhibition. However, in the presence of 10-5 or 10-4 M MEHP, the minimal concentration of CORT to inhibit the proliferation of LβT2 cells was lowered to 10-7 M, and 10-6 M RU486 was not able to completely reverse the CORT effect. In conclusion, along with the regulation of GR, 11β-HSD2 may have a key role in glucocorticoid metabolism in LβT2 cells. MEHP may participate in the glucocorticoid metabolism in LβT2 cells through inhibition of 11β-HSD2 enzyme activity. Such perturbation may be of pathological significance as MEHP may interfere with the reproductive system at pituitary level through regulation of glucocorticoid metabolism, especially in neonates with higher risk of phthalates exposure.

  19. Studio sullo stato di salute in una area con rischi ambientali pr definire interventi di sanit? pubblica

    OpenAIRE

    Romanelli, Anna Maria; Bartolacci, Simone; Cori, Liliana; Mariani, Silvia; Minichilli, Fabrizio; Protti, Maria Angela; Salvadori, Patrizia; Tacconi, Giorgia; Vigotti, Maria Angela; Bianchi, Fabrizio

    2009-01-01

    Uno studio preliminare sull'Alta Val di Cecina (AVC) aveva evidenziato tra tutte le cause di morte certificate nel periodo 1970-2004, alcuni eccessi o andamenti in controtendenza rispetto alla mortalit? regionale. L'area presenta un sottosuolo geologicamente attivo, industrie chimiche, di produzione di energia, estrattive, documentate contaminazioni di acqua e suolo e metalli pesanti. L'analisi dei dati elaborati ha evidenziato eccessi di mortalit? e di ospedalizzazione per alcune patologie p...

  20. Il processo migratorio come determinante della salute mentale: l'esperienza del Centro di Consultazione Socio-Culturale nel Distretto di Pianura Est, AUSL di Bologna.

    OpenAIRE

    Martino, Ardigò

    2012-01-01

    La ricerca in oggetto ha analizzato le relazioni tra migrazione e salute mentale nel Distretto di Pianura Est dell'AUSL di Bologna. Attraverso un dispositivo d’indagine multi-disciplinare basato sui quadri teorici dell'Antropologia Medica Critica, della Salute Pubblica e della Psichiatria, la ricerca si è inserita nell’ampio contesto di sperimentazione di un innovativo modello di assistenza per pazienti migranti, denominato Centro di Consultazione Socio- Culturale. L'architettura dello s...

  1. Selective mono-radioiodination and characterization of a cell-penetrating peptide. L-Tyr-maurocalcine

    International Nuclear Information System (INIS)

    Mono-and poly-iodinated peptides form frequently during radioiodination procedures. However, the formation of a single species in its mono-iodinated form is essential for quantitative studies such as determination of tissue concentration or image quantification. Therefore, the aim of the present study was to define the optimal experimental conditions in order to exclusively obtain the mono-iodinated form of L-maurocalcine (L-MCa). L-MCa is an animal venom toxin which was shown to act as a cell-penetrating peptide. In order to apply the current direct radioiodination technique using oxidative agents including chloramine T, Iodo-Gen registered or lactoperoxidase, an analogue of this peptide containing a tyrosine residue (Tyr-L-MCa) was synthesized and was shown to fold/oxidize properly. The enzymatic approach using lactoperoxidase/H2O2 was found to be the best method for radioiodination of Tyr-L-MCa. MALDI-TOF mass spectrometry analyses were then used for identification of the chromatographic eluting components of the reaction mixtures. We observed that the production of different radioiodinated species depended upon the reaction conditions. Our results successfully described the experimental conditions of peptide radioiodination allowing the exclusive production of the mono-iodinated form with high radiochemical purity and without the need for a purification step. Mono-radioiodination of L-Tyr-MCa will be crucial for future quantitative studies, investigating the mechanism of cell penetration and in vivo biodistribution.

  2. MAGNESIUM MONO POTASSIUM PHOSPHATE GROUT FOR P-REACTOR VESSEL IN-SITU DECOMISSIONING

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C.; Stefanko, D.

    2011-01-05

    The objective of this report is to document laboratory testing of magnesium mono potassium phosphate grouts for P-Reactor vessel in-situ decommissioning. Magnesium mono potassium phosphate cement-based grout was identified as candidate material for filling (physically stabilizing) the 105-P Reactor vessel (RV) because it is less alkaline than portland cement-based grout (pH of about 12.4). A less alkaline material ({<=} 10.5) was desired to address a potential materials compatibility issue caused by corrosion of aluminum metal in highly alkaline environments such as that encountered in portland cement grouts. Information concerning access points into the P-Reactor vessel and amount of aluminum metal in the vessel is provided elsewhere. Fresh and cured properties were measured for: (1) commercially blended magnesium mono potassium phosphate packaged grouts, (2) commercially available binders blended with inert fillers at SRNL, (3) grouts prepared from technical grade MgO and KH{sub 2}PO{sub 4} and inert fillers (quartz sands, Class F fly ash), and (4) Ceramicrete{reg_sign} magnesium mono potassium phosphate-based grouts prepared at Argonne National Laboratory. Boric acid was evaluated as a set retarder in the magnesium mono potassium phosphate mixes.

  3. High resolution seismic reflection profiles of Holocene volcanic and tectonic features, Mono Lake, California

    Science.gov (United States)

    Jayko, A. S.; Hart, P. E.; Bursik, M. I.; McClain, J. S.; Moore, J. C.; Boyle, M.; Childs, J. R.; Novick, M.; Hill, D. P.; Mangan, M.; Roeske, S.

    2009-12-01

    The Inyo-Mono Craters of Long Valley and Mono Basin, California are the youngest eruptive vents of the Great Basin, USA and the second youngest in California. They are one of two seismically active volcanic centers with geothermal power production in the Walker Lane, western Great Basin, the other being the Coso Volcanic Field to the south. High resolution seismic reflection data collected from the northern tip of the Mono Craters eruptive centers in Mono Lake delinates two structural zones proximal to the active volcanic centers in Mono Lake. A growth structure drapped by ~30 m or more of bedded sediment shows increasing deformation and offset of clastic deposits on the northwest margin of the basin. Coherent thin-bedded stratigraphic sections with strong reflectors to 30-100m depth are preserved on the western and northern margins of the basin. The southern and southeastern areas of the lake are generally seismically opaque, due to extensive ash and tephra deposits as well as widespread methane. Thin pockets of well-bedded, poorly consolidated sediment of probable Holocene and last glacial age are present within intrabasin depressions providing some local age constraints on surfaces adjacent to volcanic vents and volcanically modified features.

  4. Review of the recording and age of the Mono Lake Excursion

    Science.gov (United States)

    Coe, R.; Liddicoat, J.

    2009-04-01

    Among the brief departures from gradual, long-term behaviour of the palaeomagnetic field in the Brunhes Normal Chron that reached opposite polarity or have a Virtual Geomagnetic Pole deep in the southern hemisphere, the first to be reported is the Laschamp Excursion (LE) in volcanic rocks in the Massif Central in France (Bonhommet and Zahringer, 1969). They originally believed it occurred between about 9,000 to 20,000 years before present, but it is now assigned an age of about 40,000 years B.P. (Guillou et al., 2004). Denham and Cox (1971) unsuccessfully sought the LE in exposed lake sediments that seemed to span that interval in the Mono Basin in the western Great Basin of the U.S., but instead encountered anomalous field behaviour that is called the Mono Lake Excursion (MLE)(Liddicoat and Coe, 1979). As a tribute to Norbert Bonhommet, who assisted us in our initial field work in the Mono Basin and shared a long-standing interest in the LE and MLE, we will review the palaeomagnetic behaviour and age of the MLE in the Mono Basin and elsewhere, for which there are nearly 20 reports of its occurrence globally, and evaluate the recent suggestion that the excursion at Mono Lake and the LE are the same.

  5. Magnesium Mono Potassium Phosphate Grout For P-Reactor Vessel In-Situ Decomissioning

    International Nuclear Information System (INIS)

    The objective of this report is to document laboratory testing of magnesium mono potassium phosphate grouts for P-Reactor vessel in-situ decommissioning. Magnesium mono potassium phosphate cement-based grout was identified as candidate material for filling (physically stabilizing) the 105-P Reactor vessel (RV) because it is less alkaline than portland cement-based grout (pH of about 12.4). A less alkaline material (≤ 10.5) was desired to address a potential materials compatibility issue caused by corrosion of aluminum metal in highly alkaline environments such as that encountered in portland cement grouts. Information concerning access points into the P-Reactor vessel and amount of aluminum metal in the vessel is provided elsewhere. Fresh and cured properties were measured for: (1) commercially blended magnesium mono potassium phosphate packaged grouts, (2) commercially available binders blended with inert fillers at SRNL, (3) grouts prepared from technical grade MgO and KH2PO4 and inert fillers (quartz sands, Class F fly ash), and (4) Ceramicrete(regsign) magnesium mono potassium phosphate-based grouts prepared at Argonne National Laboratory. Boric acid was evaluated as a set retarder in the magnesium mono potassium phosphate mixes.

  6. Selective mono-radioiodination and characterization of a cell-penetrating peptide. L-Tyr-maurocalcine

    Energy Technology Data Exchange (ETDEWEB)

    Ahmadi, Mitra; Bacot, Sandrine; Perret, Pascale; Riou, Laurent; Ghezzi, Catherine [Universite Joseph Fourier, Grenoble (France); INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Poillot, Cathy; Cestele, Sandrine [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Desruet, Marie-Dominique [INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Couvet, Morgane; Bourgoin, Sandrine; Seve, Michel [CRI-INSERM U823, Grenoble (France). Inst. of Albert Bonniot; Universite Joseph Fourier, Grenoble (France); Waard, Michel de [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Smartox Biotechnologies, Grenoble (France)

    2014-07-01

    Mono-and poly-iodinated peptides form frequently during radioiodination procedures. However, the formation of a single species in its mono-iodinated form is essential for quantitative studies such as determination of tissue concentration or image quantification. Therefore, the aim of the present study was to define the optimal experimental conditions in order to exclusively obtain the mono-iodinated form of L-maurocalcine (L-MCa). L-MCa is an animal venom toxin which was shown to act as a cell-penetrating peptide. In order to apply the current direct radioiodination technique using oxidative agents including chloramine T, Iodo-Gen {sup registered} or lactoperoxidase, an analogue of this peptide containing a tyrosine residue (Tyr-L-MCa) was synthesized and was shown to fold/oxidize properly. The enzymatic approach using lactoperoxidase/H{sub 2}O{sub 2} was found to be the best method for radioiodination of Tyr-L-MCa. MALDI-TOF mass spectrometry analyses were then used for identification of the chromatographic eluting components of the reaction mixtures. We observed that the production of different radioiodinated species depended upon the reaction conditions. Our results successfully described the experimental conditions of peptide radioiodination allowing the exclusive production of the mono-iodinated form with high radiochemical purity and without the need for a purification step. Mono-radioiodination of L-Tyr-MCa will be crucial for future quantitative studies, investigating the mechanism of cell penetration and in vivo biodistribution.

  7. Ricerche sugli enterobatteri nelle feci di Chirotteri

    Directory of Open Access Journals (Sweden)

    Dino Scaravelli

    2003-10-01

    Full Text Available Dal 2002, grazie al protocollo stipulato tra il gruppo di studio chirotteri del Museo di Onferno e l?Istituto Zooprofilattico Sperimentale della Lombardia e dell?Emilia, sezione di Forlì, si è iniziato un progetto di studio sulla enteroflora di varie specie di Chirotteri. I campioni fecali o più raramente da carcassa, sono stati procssati mediante sistemi standardizzati e tipizzati mediante Enterotubes, creando anche una collezione di riferimento. Le ricerche ad oggi hanno interessato campioni provenienti da diverse regioni e da un certo pool di specie: Myotis daubentonii, M. blythii, M. myotis, Miniopterus schreibersii, Nyctalus noctula, Pipistrellus kuhlii, Rhinolophus ferrumequinum, R. hipposideros. Non sono stati mai identificati vettori di zoonosi o altri batteri che siano di alcun interesse per la salute umana, mentre si descrivono qui alcune specie nuove per la fauna italiana in relazione ai Chirotteri quali Providencia alcalifaciens in N.noctula, Serratia marcescens in M. schreibersii e Klebsiella oezaenale in R. hipposideros. Il lavoro invita inoltre ad una maggiore collaborazione e a stringere accordi per ampliare la possibile raccolta dei campioni.

  8. La teoria letteraria di Freud

    Directory of Open Access Journals (Sweden)

    Raffaele Pinto

    2013-05-01

    Full Text Available A partire dal momento in cui il sintomo nevrotico gli appare come travestimento fantastico del trauma psichico (cfr. il saggio “Le mie opinioni sul ruolo della sessualità nell’etiologia delle nevrosi”, la letteratura diventa per Freud un terreno privilegiato di analisi ai fini della ricostruzione della esperienza inconscia. In quanto entrambi dettati dalla funzione fantastico-immaginativa, tanto il sintomo quanto la letteratura sono descrivibili come elaborazioni simbolico-discorsive della pulsionalità, ma con questa essenziale differenza, che il sintomo (e il sogno, il lapsus, il witz è innanzitutto espressione di un inconscio individuale, mentre la letteratura esprime un inconscio sociale, essendo sempre fluido il passaggio da una dimensione all’altra.

  9. Masalah Kependudukan di Negara Indonesia

    OpenAIRE

    Sri Rahayu Sanusi

    2003-01-01

    Dari hasil sensus penduduk tahun 1990 jumlah penduduk Indonesia adalah 179,4 juta. Berarti Indonesia termasuk negara terbesar ke tiga di antara negaranegara yang sedang berkembang setelah Gina dan India.Dibanding dengan jumlah sensus tahun 1980 maka akan terlihat peningkatan penduduk Indonesia rata-rata 1,98% pertahun. Berdasarkan hasil proyeksi penduduk, jumlah penduduk Indonesia pada tahun 1995 sebanyak 195,3 juta jiwa. fkm-sri rahayu

  10. Penegakan Hukum di Bidang Pelayaran

    OpenAIRE

    Rosmi Hasibuan

    2002-01-01

    Perwujudan dari Peraturan Pemerintah 13 Desember 1957 tentang konsep kewilayahan Indonesia, laut lepas yang tadinya terdapat diantara pulau-pulau Indonesia berobah menjadi perairan Indonesia yang berada bawah kedaulatan Indonesia. Melalui UU No. 4/Per./1960 dan PP No. 8 Tahun 1962 Indonesia tetap menjamin kepentingan pelayaran internasional dengan memberikan kelonggaran hak lalu lintas damai bagi kapal asing di perairan nusantara (kepulauan) Indonesia. hukuminter-Rosmi3

  11. Introduzione al Laboratorio di Fisica

    Science.gov (United States)

    Ciullo, Giuseppe

    La Fisica (dal greco τὰ ϕυσικὰ: le cose naturali) si pone l'obiettivo di descrivere e prevedere il comportamento dei fenomeni naturali, nonché degli apparati e degli strumenti, che hanno reso e rendono la nostra vita più comoda ed efficiente. Tale obiettivo viene perseguito mediante un'attenta osservazione dei fenomeni, con una conseguente schematizzazione dell'osservazione, per fornire una conoscenza della realtà oggettiva, affidabile, verificabile e condivisibile.

  12. L’inopportunità di provvedimenti mirati e per singoli temi in prospettiva di riforma dei limiti della legislazione vigente in materia di libertà religiose

    Directory of Open Access Journals (Sweden)

    Valerio Tozzi

    2012-11-01

    Full Text Available SOMMARIO: 1. L'approvazione parziale delle intese già sottoscritte con i precedenti Governi e la proposta politica di Alessandro Albisetti – 2. Le perplessità sulla proposta di una legge di settore – 3. Specifica assenza di giustificazioni giuridiche al mantenimento di regimi differenziati dei matrimoni religiosi – 4. Necessità di perseguire un metodo generale e unitario di disciplina dei fenomeni religiosi da applicare a ogni settore – 5. La impraticabilità di una politica legislativa costituzionalmente adeguata e le sue cause.

  13. Development of a gas chromatography-mass spectrometry method to monitor in a single run, mono- to triterpenoid compounds distribution in resinous plant materials.

    Science.gov (United States)

    Jemmali, Zaineb; Chartier, Agnes; Elfakir, Claire

    2016-04-22

    A new procedure based on gas chromatography coupled to mass spectrometry (GC-MS) was developed for the simultaneous determination of mono- to triterpenoid compounds in resinous materials. Given the difference of volatility and polarity of the studied compounds some critical steps in this methodology had to be identified and investigated. The recovery of volatile compounds after sample extraction was studied. A recovery range from 30% to 100% from the more volatile monoterpene to the least one was observed. Then the mandatory derivatization step for the analysis of pentacyclic triterpenes bearing hydroxyl and carboxyl groups was optimized. Results showed that derivatization using N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and trimethylchlorosilane (TMCS) in pyridine (22:13:65 v/v/v) for 2h at 30°C was the most efficient method of derivatizing all the hydroxyl and carboxylic acid groups contained in the triterpene structures. After choosing the best injection parameters for these compounds, the selectivity of the GC column towards the separation of these terpenoids was investigated using statistical tools (principal component analysis and desirability functions). A separation with a good resolution was achieved on an HP-5ms column using a programmed temperature vaporizing injector (PTV). The method was pre-validated in terms of detection limits (LOD from 100μgL(-1) to 200μgL(-1) depending on the compound), linearity and repeatability using seven compounds representative of mono- and triterpenoid classes. An exhaustive characterization of various types of resins (di-, triterpenic and oleo-gum resins) was achieved. PMID:27018190

  14. Analisi quantitative e di contenuto di un parent training per genitori di bambini con ADHD: uno studio pilota,

    OpenAIRE

    Pezzica S.; Tarchi C.; Piccinelli F; Bigozzi L

    2013-01-01

    Il lavoro si propone di indagare le principali aree tematiche su cui si orienta la narrazione dei genitori partecipanti ad un gruppo di Parent Training per verificare in che modo esse si inseriscano e si modifichino durante il processo di cambiamento. The present contribution aims at inquiring the main areas around which the narration of parents participating to a Parent Training group is oriented, in order to verify how such narrations are embed and modify during the change process.

  15. La ricostruzione grafica del pavimento musivo di una villa romana

    Directory of Open Access Journals (Sweden)

    Caterina Gattuso

    2015-01-01

    Full Text Available Nel processo di analisi conoscitiva finalizzato alla conservazione e/o al restauro di un manufatto storico, la documentazione grafica offre un contributo importante ai fini della redazione del quadro anamnesico. Essa costituisce uno strumento conoscitivo che, nel rappresentare e registrare lo stato di conservazione nonché gli eventuali interventi di restauro cui il bene è stato sottoposto, permette di completare e di integrare le informazioni già ottenute mediante il dossier fotografico. In questo contesto si vuole dimostrare l’importanza del disegno informatico, da intendere come strumento utile per l’elaborazione di un corretto piano diagnostico, illustrando la ricostruzione grafica di una complessa pavimentazione musiva che decora un particolare ambiente di una villa di epoca romana posta sulle rive del lago d’Esaro nel comune di Roggiano Gravina (CS, ottenuta attraverso l’uso di un particolare software di design grafico e disegno vettoriale.

  16. Di-photon excess at LHC and the gamma ray excess at the Galactic Centre

    CERN Document Server

    Hektor, Andi

    2016-01-01

    Motivated by the recent indications for a 750 GeV resonance in the di-photon final state at the LHC, in this work we analyse the compatibility of the excess with the broad photon excess detected at the Galactic Centre. Intriguingly, by analysing the parameter space of an effective models where a 750 GeV pseudoscalar particles mediates the interaction between the Standard Model and a scalar dark sector, we prove the compatibility of the two signals. We show, however, that the LHC mono-jet searches and the Fermi LAT measurements strongly limit the viable parameter space. We comment on the possible impact of cosmic antiproton flux measurement by the AMS-02 experiment.

  17. La necropoli neolitica a domus de janas di S. Pietro di Sorres in Comune di Borutta - Sassari

    Directory of Open Access Journals (Sweden)

    Pier Paolo Soro

    2009-05-01

    Full Text Available La necropoli di Sorres si trova nel territorio del Comune di Borutta in provincia di Sassari. E’ ubicata lungo il versante SE del colle di Sorres, sul quale sorge imponente la chiesa in stile romanico di San Pietro di Sorres (XI-XII sec. sede dell’antica diocesi medievale. La necropoli è composta attualmente da cinque tombe a grotticella artificiale del tipo a domus de janas, scavate nella roccia calcara durante il neolitico recente ed in uso per tutto l’eneolitico. Si presume che fosse l’area sepolcrale dell’insediamento in grotta di Ulàri, una cavità carsica di notevoli dimensioni il cui ingresso si apre lungo il versante Nord del colle; la grotta ha restituito testimonianze archeologiche che vanno dal neolitico media fino al medioevo. La necropoli di Sorres, sebbene sia stata rimaneggiata nella forma degli ambienti ipogei e nella destinazione d’uso, costituisce una delle principali testimonianze del capillare tessuto insediativo del territorio del nord Sardegna.

  18. Studio di caratteri correlati a stress idrico in una collezione di cultivar di frumento duro (Triticum durum Desf.)

    OpenAIRE

    Francia, Rossella

    2013-01-01

    L’agricoltura si trova ad affrontare una diminuzione della disponibilità d’acqua ed una crescente domanda della produzione di cereali per scopi alimentari. Sono perciò necessarie strategie di coltivazione innovative per migliorare la produttività e nuovi genotipi migliorati nell'efficienza dell’uso delle risorse in condizioni di siccità. Questi rappresentano gli obietti principali del progetto “DROPS” (Drought tolerant yielding Plants) all’interno del quale ha avuto luogo il mio progetto di D...

  19. Geochemical fingerprinting of Wilson Creek formation tephra layers (Mono Basin, California) using titanomagnetite compositions

    Science.gov (United States)

    Marcaida, Mae; Mangan, Margaret T.; Vazquez, Jorge A.; Bursik, Marcus; Lidzbarski, Marsha I.

    2014-03-01

    Nineteen tephra layers within the Wilson Creek formation near Mono Lake provide a record of late Pleistocene to early Holocene volcanic activity from the nearby Mono Craters and are important chronostratigraphic markers for paleomagnetic, paleoclimatic, and paleoecologic studies. These stratigraphically important tephra deposits can be geochemically identified using compositions of their titanomagnetite phenocrysts. Titanomagnetite compositions display a broad range (XUsp 0.26-0.39), which allow the tephra layers to be distinguished despite the indistinguishable major-element glass compositions (76-77 wt% SiO2) of their hosts. The concentrations of Ti and Fe in titanomagnetite display geochemical and stratigraphic groupings that allow clear discrimination between older (> 57 ka) and younger (Mono Craters-sourced titanomagnetites also allows the discrimination of two tephra layers apparently sourced from nearby Mammoth Mountain volcano in Long Valley.

  20. Anaerobic Halo-Alkaliphilic Baterial Community of Athalassic, Hypersaline Mono Lake in California

    Science.gov (United States)

    Pikuta, Elena V.; Hoover, Richard B.; Marsic, Damien; Ng, Joseph D.; Six, N. Frank (Technical Monitor)

    2002-01-01

    The microorganisms of soda Mono Lake and other similar athalassic hypersaline alkaline soda lakes are of significance to Astrobiology. The microorganisms of these regimes represent the best known terrestrial analogs for microbial life that might have inhabited the hypersaline alkaline lakes and evaporites confined within closed volcanic basins and impact craters during the late Noachian and early Hesperian epochs (3.6 - 4.2 Gya) of ancient Mars. We have investigated the anaerobic microbiota of soda Mono Lake in northern California. In this paper we discuss the astrobiological significance of these ecosystems and describe several interesting features of two novel new species of anaerobic halo-alkaliphilic bacteria (Spirochaeta americana, sp. nov. and Desulfonatronum paiuteum, sp. nov) that we have isolated from Mono Lake.

  1. Analisi dell’utilizzo di Twitter nella costruzione di un seminario sperimentale

    Directory of Open Access Journals (Sweden)

    Wolfgang Reinhardt

    2013-03-01

    Full Text Available Nonostante i massicci cambiamenti sociali e tecnologici che si sono verificati a causa del Web negli ultimi anni, i corsi universitari spesso enfatizzano metodi di insegnamento da tempo consolidati e basati su strumenti di apprendimento e risorse tradizionali. Durante tali corsi gli studenti spesso acquisiscono una conoscenza che non è aggiornata e che è lontana da un apprendimento realistico, basato su problemi. L'uso di strumenti e metodi più recenti spesso rimane fuori dalla padronanza degli studenti. In questo contributo si descrive brevemente l’impostazione sperimentale di un seminario in due università tedesche dove l’uso di Social Media per la comunicazione e la collaborazione è stato saldamente integrato alla progettazione di un percorso di apprendimento formale. Si illustra, inoltre, l'utilizzo di Twitter durante il seminario, usando metodologie riprese dalla Social Network Analysis.

  2. Creazione e gestione di una collezione di e-book per biblioteche universitarie

    OpenAIRE

    Perrone, Agnese

    2006-01-01

    L'intervento illustra un progetto della biblioteca della Northumbria University, che riguarda lo sviluppo, la gestione e la valutazione di una collezione di e-book a supporto della ricerca e didattica.

  3. Libertà religiosa e libertà di educazione di fronte alla Corte di Strasburgo

    Directory of Open Access Journals (Sweden)

    Vincenzo Turchi

    2012-10-01

    Full Text Available Contributo sottoposto a valutazioneSOMMARIO: 1. Libertà religiosa e libertà di educazione: note preliminari – 2. Consiglio d’Europa ed Unione Europea: la salvaguardia dei diritti dell’uomo e delle libertà fondamentali – 3. La Corte europea dei diritti dell’uomo – 4. La funzione interpretativa della Corte nel diritto interno. In particolare, quale fonte integratrice del parametro interposto di costituzionalità ex art. 117, comma 1° Cost. – 5. Educazione e religione nella giurisprudenza della Corte europea dei diritti dell’uomo. I rapporti familiari – 6. Libertà religiosa e libertà di educazione nel prisma della struttura scolastica. Le scuole confessionalmente orientate – 7. Gli insegnamenti obbligatori di religione – 8. I simboli religiosi – 9. In particolare, la “questione” del crocifisso (caso Lautsi c. Italia – 10. Sintesi conclusiva.ABSTRACT:The purpose of the paper consists in examining the cases submitted to the European Court of Human Rights in which religious freedom (art. 9 of European Convention of Human Rights is, in a specific way, related to the right to education (art. 1 of Protocol 1. The fields where arise most important problems are as follows: family relationship, denominational Schools, compulsory denominational (confessional instruction in Schools, religious symbols in State Schools. From the latest judgments at Strasbourg Court, it seems to emerge a new perspective of the principle of laicità, clearly open to social pluralism. As the Court stated concerning educative pluralism: “the possibility of pluralism in education […] is essential for the preservation of the “democratic society” as conceived by the Convention”.

  4. La nozione di Analiticità e di conoscenza A Priori

    Directory of Open Access Journals (Sweden)

    Maria Teresa Bradascio

    2015-05-01

    Full Text Available Le nozioni di analiticità e di conoscenza a priori continuano ad essere impiegate nella filosofia contemporanea nonostante siano state oggetto di critiche e dibattiti per dimostrarne l’inutilità. Le domande alle quali si è cercato – e si cerca tuttora – di dare una risposta sono: quali tipi di proposizioni possono essere giustificate e conosciute a priori? Che rapporto c’è tra l’analiticità e l’a priori? Il mio intento è offrire un’analisi della nozione di analiticità presente in Frege e in Quine utilizzando come riferimento, rispettivamente, “I fondamenti dell’aritmetica” (1884 e l’articolo “Due Dogmi dell’Empirismo” (1953. Nell’opera di Frege si trova una prima riformulazione della coppia di nozioni ereditate dalla tradizione kantiana e leibniziana: per Leibniz una verità di ragione, sviluppando semplicemente il contenuto di una proposizione che già conosciamo, non amplia le nostre conoscenze, e dunque è analitica; mentre una verità di fatto amplia le nostre conoscenze, aggiungendo qualcosa che non avremmo potuto scoprire contemplando solamente i concetti e i loro rapporti logici. Le proposizioni logiche, aritmetiche e certe verità concettuali – quelle ottenute mediante definizione nominale – sono considerate proposizioni analitiche. Per Kant, invece, sia le proposizioni aritmetiche sia quelle geometriche ampliano la nostra conoscenza e sono sintetiche. L’obiettivo di Frege è mostrare l’errore della concezione kantiana dell’analiticità: l’incremento conoscitivo ottenibile dalle proposizioni aritmetiche non è in opposizione al loro carattere analitico. Egli, infatti, legando il carattere analitico o sintetico di un enunciato al tipo di giustificazione che possiamo portare a sostegno della sua asserzione, non definisce l’analiticità come una caratteristica evidente del significato di un enunciato. Nel caso degli enunciati dell’aritmetica la loro giustificazione consiste nella loro

  5. IL RICORSO STRAORDINARIO PER ERRORE DI FATTO

    OpenAIRE

    Gialuz, Mitja

    2004-01-01

    Inserito nel tessuto codicistico quasi surrettiziamente, nel contesto di una manovra legislativa diretta a rafforzare gli strumenti normativi a «tutela della sicurezza dei cittadini», il «ricorso straordinario per errore materiale o di fatto» costituisce un unicum nella storia legislativa dell'Italia unita. Prima del 2001, non era mai stato previsto - almeno in ambito processuale penale - un mezzo destinato a porre rimedio agli errori della Corte di cassazione, i provvedimenti della quale, in...

  6. Simboli religiosi e processo di mediazione

    OpenAIRE

    Nicola Colaianni

    2014-01-01

    Il contributo, sottoposto a valutazione, è destinato alla pubblicazione negli Atti del Seminario Internacional de Profesores sul tema“Neutralidad del estado, religiones e ideologías”, organizzato dall’Universidad Complutense, tenutosi a Madrid il 21 novembre 2013.SOMMARIO: 1. Le nuove “guerre di religione”: tra credenti e noncredenti – 2. Lo spazio pubblico urbano: a) la posizione di simboli religiosi – 3. (segue:) b) la rimozione di simboli preesistenti – 4. Lo spazio pubblico istituzionale:...

  7. Facebook, adolescenti e differenze di classe

    OpenAIRE

    Micheli, M.

    2013-01-01

    La popolarità dei siti di social network tra gli adolescenti sembrerebbe suggerire che si tratti di un campo in cui l’influenza dell’origine sociale, se non scomparsa, si sia almeno livellata. Questo articolo mette invece in evidenza come la classe sociale della famiglia continui ad essere una variabile rilevante che influisce sull’uso e il significato che gli adolescenti attribuiscono ai siti di social network. Oltre a fornire una revisione della letteratura attualmente disponibile sull’...

  8. KEANEKARAGAMAN ANGGREK DI HUTAN SULAWESI SELATAN

    OpenAIRE

    Sri Suhadiyah; Elis Tambaru; Rinaldi Sjahril; Muh. Ruslan Umar

    2015-01-01

    Penelitian keanekaragaman anggrek di hutan Sulawesi Selatan telah dilakukan pada bulan Oktober-November 2012, dihutan Pattunuang, Kabupaten Maros dan di hutan Bolli Kabupaten Enrekang .Tujuan penelitian ini untuk mengetahui keranekagaman spesies anggrek dan pohon inangnya. Penelitian dilakukan dengan menggunakan metode jelajah. Hasil penelitian di hutan Pattunuang diperoleh 12 genus yang terdiri dari 15 spesies anggrek , tumbuh pada 10 spesies pohon inang . Spesies yang banyak jumlahnya adala...

  9. Conservazione del seme sortato di suino

    OpenAIRE

    Vallorani, Claudia

    2012-01-01

    Gli spermatozoi di suino sottoposti alla procedura di sessaggio mediante citofluorimetria presentano una serie di modificazioni morfo-funzionali che compromettono nel tempo la loro sopravvivenza e la capacità fecondante. Questi spermatozoi, inoltre, a causa della sensibilità ai danni indotti dalla crioconservazione, vengono solitamente conservati allo stato liquido a 15-17°C, con conseguente ulteriore peggioramento nel tempo della qualità delle cellule spermatiche sessate. Lo scopo della r...

  10. Sicurezza Informatica di Istituto: Politica e Organizzazione

    OpenAIRE

    Carlesi, Carlo

    2004-01-01

    La sicurezza informatica, e' piu' che una necessita' e richiede di essere affrontata in modo omogeneo e funzionale alle diverse realta' presenti nell'ISTI per conciliare diverse esigenze: . proteggere i propri investimenti . rispettare le normative legali vigenti in tema di sicurezza dei sistemi per il trattamento automatico dell'informazione (information technology system o sistemi IT) . preservare la propria immagine istituzionale. Nel contesto di questo documento, con il termine 'sicurezza...

  11. Sviluppo e valutazione di test diagnostici per la sierodiagnosi di brucellosi suina

    Directory of Open Access Journals (Sweden)

    Tiziana Di Febo

    2012-06-01

    Full Text Available Sono stati sviluppati una ELISA competitiva (c-ELISA, una ELISA indiretta (i-ELISA e un test immunologico DELFIA (Dissociation-Enhanced Lanthanide Fluorescence Immunoassay per la ricerca di anticorpi verso Brucella suis in sieri di maiale e cinghiale. I tre test prevedono l’utilizzo di un anticorpo monoclonale (MAb 4B5A verso l’LPS di Brucella (c-ELISA e DELFIA e di un anticorpo monoclonale (MAb 10C2G5 verso le IgG suine (i-ELISA. La specificità (Sp e la sensibilità (Se dei tre test sono le seguenti: per la c-ELISA Se e Sp = 100% con un valore di cut-off pari al 61.0% (B/B0%; per la i-ELISA Sp = 99.1% e Se = 100% con un valore di cut-off di 21.7% (PP%; per il DELFIA Sp = 91.0% e Se = 75% ponendo il valore di cut-off al 37.0% (B/B0%. Inoltre sono state valutate le performance, nei confronti di sieri suini, di un test FPA (Fluorescence Polarization Assay commerciale sviluppato per la ricerca di anticorpi anti-Brucella in sieri bovini; la specificità e la sensibilità ottenute sono entrambe del 100% al valore di cut-off di 99.5 (mP. Questi risultati suggeriscono che la combinazione di c-ELISA, i-ELISA e FPA può essere utilizzata per migliorare la diagnosi di brucellosi suina.

  12. Il significato di una pubblicazione. La cosiddetta contaminazione nell’antica commedia romana di Pietro Ferrarino

    OpenAIRE

    2003-01-01

    Agli occhi del lettore moderno, il famoso studio sulla commedia romana di Ferrarino appare come una sintesi ideale della tradizione filologica tedesca e del criticismo basato sul metodo di Croce, ereditato dal suo insegnante Gino Funaioli. All’interno della ricostruzione storica di Ferrarino, con la sua accuratezza altamente scientifica, prevale comunque il debito nei confronti della filologia pura, che in Italia è stata esemplificata nei lavori di Giorgio Pasquali.

  13. Kajian Kedelai di Bawah Pertanaman Kelapa Sawit Umur Empat Tahun di PTPN III Kebun Rambutan

    OpenAIRE

    Wardhana, Surya

    2015-01-01

    Surya Wardhana, “Kajian Kedelai di Bawah Pertanaman Kelapa Sawit Umur Empat Tahun di PTPN III Kebun Rambutan”. Dibawah bimbingan Lisa Mawarni dan Asil Barus. Untuk mengetahui pertumbuhan dan produksi kedelai di bawah pertanaman kelapa sawit umur empat tahun, untuk itu telah dilakukan penelitian di PTPN III Kebun Rambutan, mulai Februari 2012 sampai bulan Mei 2012. Rancangan yang digunakan adalah Rancangan Acak Kelompok dengan 2 faktor perlakuan. Faktor pertama sebagai petak utama adalah va...

  14. ANALISI DI INTEGRATORITEMPORALI APPLICATI AGLI ELEMENTI FINITI E AL METODO DI PROVA PSEUDODINAMICO

    OpenAIRE

    BONELLI, ALESSIO

    2001-01-01

    La corretta valutazione della risposta delle strutture soggette ad azioni dinamiche quali terremoti oppure il vento risulta di fondamentale interesse nell'ingegneria civile. In generale, l'evoluzione di un fenomeno di dinamica strutturale può essere descritta, in modo rigoroso, attraverso la soluzione di equazioni alle derivate parziali su un dominio spazio-temporale, con condizioni al contorno ed iniziali. Risolvere queste equazioni in forma chiusa è, spesso, impossibile, per cui si ricorre ...

  15. Studi di permeazione cutanea in vitro di polveri e nanoparticelle metalliche

    OpenAIRE

    Crosera, Matteo

    2010-01-01

    Il ruolo della cute è stato a lungo sottostimato, soprattutto in ambito professionale: essa era considerata una barriera impermeabile alle sostanze chimiche. Oggi è noto che molti agenti tossici sono in grado di penetrare attraverso la pelle e l’assorbimento cutaneo è un fenomeno molto studiato nell’ambito di una completa valutazione dei fattori di rischio sia in ambito professionale che ambientale. Gli studi di assorbimento percutaneo in vitro possono essere usati per definire le caratterist...

  16. Le cure oncologiche e la prospettiva del paziente. Revisione di letteratura e un caso di studio

    OpenAIRE

    Foglino, Silvia

    2015-01-01

    Numerose ricerche indicano i modelli di cure integrate come la migliore soluzione per costruire un sistema più efficace ed efficiente nella risposta ai bisogni del paziente con tumore, spesso, però, l’integrazione è considerata da una prospettiva principalmente clinica, come l’adozione di linee guida nei percorsi della diagnosi e del trattamento assistenziale o la promozione di gruppi di lavoro per specifiche patologie, trascurando la prospettiva del paziente e la valutazione della sua esperi...

  17. Studi di conservazione ed ecologia della germinazione di specie psammofile della costa molisana

    OpenAIRE

    Giuliano, Mariaconcetta

    2010-01-01

    La conservazione della biodiversità rappresenta un tema di crescente interesse nella ricerca scientifica, ma anche nell’attività governativa a livello mondiale. Il presente lavoro si articola operando per mezzo di un duplice approccio: sviluppando studi di conservazione in situ, attraverso l’analisi degli habitat e della flora costiera, ed attuando azioni di conservazioni ex situ, in banca del germoplasma, non solo per taxa rari o minacciati ma anche per quelle specie che, mediante le part...

  18. Caratterizzazione di batteri pigmentati e studio degli effetti di molecole batteriche e vegetali su cellule umane

    OpenAIRE

    Manzo, Nicola

    2013-01-01

    Il lavoro svolto durante questi tre anni di Dottorato è raccolto in questa Tesi ed è suddiviso in quattro capitoli distinti. Due capitoli sono dedicati alla caratterizzazione di bacilli produttori di carotenoidi, uno all'interazione tra il batterio lattico Lactobacillus gasseri e cellule dell'epitelio intestinale umano ed uno agli effetti di un estratto della pianta Aloe arborescens su diverse linee cellulari umane. Tali argomenti, anche se apparentemente indipendenti, sono invece strettam...

  19. Misura della concentrazione di radon nell’acqua potabile di Roma

    OpenAIRE

    Mancini, C.; Dept. of Nuclear Engineering and Conversion of Energy. Univ. "La Sapienza". Rome; Galli, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Roma1, Roma, Italia; Mattiacci Delle Salette, M.; Azienda USL Roma C, Roma; Diotallevi, R.; Azienda USL Roma C, Roma

    2007-01-01

    Sono state eseguite misure di concentrazione di 222Rn nell’acqua potabile della rete idrica di Roma con prelievi dalle principali adduttrici (acquedotti del Peschiera, Marcio, ..) e da pozzi. Il metodo impiegato si basa sull’adsorbimento in carboni attivi del radon estratto per degassamento dal campione dell’acqua in esame. I risultati mostrano concentrazioni dell’ordine del Bq/L nell’acqua dei principali acquedotti e nella rete di distribuzione. Concentrazioni maggiori (inferiori comunque a...

  20. Sistemi per la produzione di enzimi industriali finalizzati alla valorizzazione di scarti agroalimentari

    OpenAIRE

    Masutti, Dayanne Christine

    2014-01-01

    La demolizione idrolitica delle pareti cellulari delle piante tramite enzimi lignocellulosici è quindi uno degli approcci più studiati della valorizzazione di scarti agricoli per il recupero di fitochimici di valore come secondary chemical building block per la chimica industriale. White rot fungi come il Pleurotus ostreatus producono una vasta gamma di enzimi extracellulari che degradano substrati lignocellulosici complessi in sostanze solubili per essere utilizzati come nutrienti. In que...

  1. Domotica e disabilità negli ambienti di apprendimento. Esiti di un progetto

    OpenAIRE

    Tamara Zappaterra

    2013-01-01

    In un lavoro sinergico ed interdisciplinare tra ricercatori dell’area pedagogica, dell’area ingegneristica e di quella medica, si è testata la possibilità di adattamento di dispositivi domotici all’ambiente scolastico, ambito non ancora esplorato dalla domotica, ed è stato progettato e realizzato un prototipo di dispositivo innovativo ed originale modellato sulle peculiarità dell’utente nel contesto scolastico. Per quanto riguarda i risultati raggiunti,sono state realizzate tre stazioni domot...

  2. Esempi di antisemitismo culturale nel romanzo 'Il cimitero di Praga' di Umberto Eco

    Directory of Open Access Journals (Sweden)

    Maria Grazia Cossu

    2013-01-01

    Full Text Available Examples of Cultural Anti-Semitism in Umberto Eco’s Novel Il cimitero di PragaThe article draws upon Umberto Eco’s recent novel, Il cimitero di Praga, in the consideration of the relationship between narrative fiction and the collective imagination in regards to the genesis and dispersion of The Protocols of the Elders of Zion in the second half of the nineteenth century. A dangerous and mysterious text, The Protocols evoked general clamor and persecutory backlash, as it appeared to document the existence of a Judeo-Masonic conspiracy.In the work, the author also reconstructs sources of the fictional text and traces the historical, political and editorial events surrounding it, plunging into them with a gritty and irreverent realism in a chronicle of the obsession that flowed into the madness of the Shoah.Treating the subject, which is found elsewhere in the scholar’s oeuvre, requires mention of the repertoire of prejudicial accusations against the Jews throughout history, which creates, toward the end of the book, a heated and contentious debate regarding whether such delicate and reckless statements should even be made public at all. This article questions the authorial strategy in Il cimitero di Praga, and considers the novel’s literary agenda, which can be almost interpreted as a call for vigilance against manifestations of anti-Semitism still present in today’s cultural imagination.

  3. Communication: Linking the dielectric Debye process in mono-alcohols to density fluctuations.

    Science.gov (United States)

    Hecksher, Tina

    2016-04-28

    This work provides the first direct evidence that the puzzling dielectric Debye process observed in mono-alcohols is coupled to density fluctuations. The results open up for an explanation of the Debye process within the framework of conventional liquid-state theory. The spectral shape of the dynamical bulk modulus of the two studied mono-alcohols, 2-ethyl-1-hexanol and 4-methyl-3-heptanol, is nearly identical to that of their corresponding shear modulus, and thus the supramolecular structures believed to be responsible for the slow dielectric Debye process are manifested in the bulk modulus in the same way as in the shear modulus. PMID:27131521

  4. Mono- or bis-ligand complexes are better for chelation therapy? Theoretical approaches

    Science.gov (United States)

    Jakusch, Tamás; Kiss, Tamás

    2014-10-01

    In our theorethical approach we would like to point out that the dissociation constant (Kd value) of the complexes itself not enough parameter to describe the metal ion binding ability of the MPACS. The ligand concentration dependence of the free metal ion concentration is stronger is bis- or tris complexes are also formed (second or third order), than just mono complex (first order) exists, the theoretical therapeutic window should be more wide for tetra- penta- or hexadentate ligands (only mono complexes formed) than for bi- or tridentate chelators (bis- and tris complex formation is possible).

  5. A study of the growth of Pseudomonas putida CP1 on mono-chlorophenols

    OpenAIRE

    Fakhruddin, A. N. M.

    2003-01-01

    Pseudomonas putida CPI grew on all three mono-chlorophenol isomers when supplied as the sole source of carbon and energy. The biodegradability of the mono-chlorophenols followed the order: 4-chlorophenol > 2-chlorophenol > 3-chlorophenol. P. putida CPI was able to degrade 300 ppm 4-chlorophenol, 250 ppm 2-chlorophenol and 200 ppm of 3-chlorophenol. In the presence of fructose (1%, w/v) the organism could degrade 400 ppm 4-chlorophenol, 500 ppm 2-chlorophenol and 300 ppm 3-chlorophenol. Ch...

  6. HMM and IOHMM for the Recognition of Mono- and Bi-Manual 3D Hand Gestures

    OpenAIRE

    Just, Agnès; Bernier, O.; Marcel, Sébastien

    2004-01-01

    In this paper, we address the problem of the recognition of isolated complex mono- and bi-manual hand gestures. In the proposed system, hand gestures are represented by the 3D trajectories of blobs obtained by tracking colored body parts. In this paper, we study the results obtained on a complex database of mono- and bi-manual gestures. These results are obtained by using Input/Output Hidden Markov Model (IOHMM), implemented within the framework of an open source machine learning library, and...

  7. Recognition of Isolated Complex Mono- and Bi-Manual 3D Hand Gestures

    OpenAIRE

    Just, Agnès; Bernier, O.; Marcel, Sébastien

    2004-01-01

    In this paper, we address the problem of the recognition of isolated complex mono- and bi-manual hand gestures. In the proposed system, hand gestures are represented by the 3D trajectories of blobs. Blobs are obtained by tracking colored body parts in real-time using the EM algorithm. In most of the studies on hand gestures, only small vocabularies have been used. In this paper, we study the results obtained on a more complex database of mono- and bi-manual gestures. These results are obtaine...

  8. Systemic Cytokine and Interferon Responsiveness Patterns in HIV and HCV Mono and Co-Infections

    OpenAIRE

    Fernandez-Botran, Rafael; Joshi-Barve, Swati; Ghare, Smita; Barve, Shirish; Young, Mary; Plankey, Michael; Bordon, Jose

    2014-01-01

    The role of host response-related factors in the fast progression of liver disease in individuals co-infected with HIV and HCV viruses remains poorly understood. This study compared patterns of cytokines, caspase-1 activation, endotoxin exposure in plasma as well as interferon signaling in peripheral blood mononuclear cells from HIV/HCV co-infected (HIV+/HCV+), HCV mono-infected (HIV−/HCV+), HIV mono-infected (HIV+/HCV−) female patients and HIV- and HCV-uninfected women (HIV−/HCV−) who had en...

  9. Self-assembled and electrochemically deposited mono/multilayers for molecular electronics applications

    International Nuclear Information System (INIS)

    For the development of molecular electronics, it is desirable to investigate characteristics of organic molecules with electronic device functionalities. In near future, such molecular devices could be integrated with silicon to prepare hybrid nanoelectronic devices. In this paper, we review work done in our laboratory on study of characteristics of some functional molecules. For these studies molecular mono and multilayers have been deposited on silicon surface by self-assembly and electrochemical deposition techniques. Both commercially available and specially designed and synthesized molecules have been utilized for these investigations. We demonstrate dielectric layers, memory, switching, rectifier and negative differential resistance devices based on molecular mono and multilayers.

  10. Communication: Linking the dielectric Debye process in mono-alcohols to density fluctuations

    Science.gov (United States)

    Hecksher, Tina

    2016-04-01

    This work provides the first direct evidence that the puzzling dielectric Debye process observed in mono-alcohols is coupled to density fluctuations. The results open up for an explanation of the Debye process within the framework of conventional liquid-state theory. The spectral shape of the dynamical bulk modulus of the two studied mono-alcohols, 2-ethyl-1-hexanol and 4-methyl-3-heptanol, is nearly identical to that of their corresponding shear modulus, and thus the supramolecular structures believed to be responsible for the slow dielectric Debye process are manifested in the bulk modulus in the same way as in the shear modulus.

  11. Comparative structure analysis of non-polar organic ferrofluids stabilized by saturated mono-carboxylic acids.

    Science.gov (United States)

    Avdeev, M V; Bica, D; Vékás, L; Aksenov, V L; Feoktystov, A V; Marinica, O; Rosta, L; Garamus, V M; Willumeit, R

    2009-06-01

    The structure of ferrofluids (magnetite in decahydronaphtalene) stabilized with saturated mono-carboxylic acids of different chain lengths (lauric, myristic, palmitic and stearic acids) is studied by means of magnetization analysis and small-angle neutron scattering. It is shown that in case of saturated acid surfactants, magnetite nanoparticles are dispersed in the carrier approximately with the same size distribution whose mean value and width are significantly less as compared to the classical stabilization with non-saturated oleic acid. The found thickness of the surfactant shell around magnetite is analyzed with respect to stabilizing properties of mono-carboxylic acids. PMID:19376524

  12. p-Type Quasi-Mono Silicon Solar Cell Fabricated by Ion Implantation

    OpenAIRE

    Chien-Ming Lee; Sheng-Po Chang; Shoou-Jinn Chang; Ching-In Wu

    2013-01-01

    The p-type quasi-mono wafer is a novel type of silicon material that is processed using a seed directional solidification technique. This material is a promising alternative to traditional high-cost Czochralski (CZ) and float-zone (FZ) material. Here, we evaluate the application of an advanced solar cell process featuring a novel method of ion implantation on p-type quasi-mono silicon wafer. The ion implantation process has simplified the normal industrial process flow by eliminating two proc...

  13. Transitional Care: implementazione di un modello organizzativo multidimensionale di cure intermedie

    Directory of Open Access Journals (Sweden)

    Davide Minniti

    2014-06-01

    Full Text Available Background. I rapidi cambiamenti demografici hanno profondamente modificato il funzionamento della rete dei servizi ospedalieri e territoriali. Il modello di cure intermedie (CI o transitional care è un servizio “ponte” tra ospedale e territorio che rappresenta una difficile sfida perché deve rispondere a specifici requisiti di appropriatezza, efficacia, efficienza e sicurezza. Per far fronte alla situazione socio-economica attuale ed in riferimento al PSSR 2010-2015, il Piemonte ha recentemente attuato un piano di rientro che mira a superare l’inappropriatezza di alcune prestazioni e delle loro modalità di erogazione. Di conseguenza la DGR n. 6-5519 del 14/03/13 ha previsto per l’ASL TO3 la riconversione di 5 ospedali in strutture di assistenza territoriale per le CI. Obiettivi.Valutare l’appropriatezza organizzativa, l’efficacia e l’efficienza delle diverse dimensioni del modello organizzativo di CI: Centro di Assistenza Primaria (CAP, Servizio di Telemedicina (ST, Continuità Assistenziale a Valenza Sanitaria (CAVS. Metodi. La prima fase ha previsto l’apertura del CAP presso il presidio ospedaliero di Avigliana. Si è poi provveduto ad attivare il ST dell’ASL TO3. Sono stati calcolati i volumi di attività di entrambi i servizi, relativamente ai primi sei mesi dall’apertura, ed è stato misurato l’impatto di questo nuovo modello organizzativo sull’attività della struttura di Emergenza di riferimento presso il DEA di Rivoli. Per la CAVS, inoltre, si è provveduto ad effettuare un’analisi di appropriatezza ex ante ed un’analisi dei costi. Risultati. Il totale degli accessi al CAP, nei mesi indice del 2013, è di circa 2000 casi, con una media di 14 pazienti/die. Il 70% dei casi ha richiesto l’intervento medico. Le cause di accesso più comuni sono state i traumi (22%. Nel 65% dei casi l’esito è stato la dimissione a domicilio. Per la CAVS, un’analisi delle SDO ha dimostrato che il numero di posti letto per

  14. OLIMPIADI NAZIONALI DI LINGUA ITALIANA 2011

    OpenAIRE

    Ugo Cardinale

    2012-01-01

    L’articolo presenta l’ultima edizione delle Olimpiadi nazionali di lingua italiana, promosse dal Miur-Direzione generale per gli ordinamenti scolastici, dalla Città di Firenze, dall’Accademia della Crusca, dall’Università di Firenze, nell’anno della celebrazione dei centocinquant’anni dell’Unità d’Italia, illustrandone le diverse fasi, di istituto, regionali e nazionale, le prove (riguardanti cinque aree: a. ortografia e fonetica; b. morfologia e formazione delle parole; c. sintassi; d. lessi...

  15. Il controllo di gestione e operativo delle commesse per una impresa di costruzioni: nuovo impianto di trattamento e recupero di rifiuti urbani.

    Directory of Open Access Journals (Sweden)

    Matteo Camprini

    2013-10-01

    Full Text Available Il mercato delle costruzioni in Italia soffre problemi di maturità da molto tempo. Dagli anni ’90, infatti, per superare i fatti di tangentopoli venne riformata la legislazione dei lavori pubblici per giungere a livelli di competizione maggiori e più simili a quelli esistenti in Europa.  In questo contesto le imprese che per la loro struttura culturale, organizzativa e produttiva mostravano maggiore sensibilità a tali aspetti avviarono processi di formazione e riorganizzazione introducendo specifiche procedure mirate alla gestione completa dei progetti trasformandosi così da imprese di sola produzione a imprese operanti per progetti.La presente memoria vuole descrivere il sistema di gestione attuato, le modifiche ed i miglioramenti che si sono susseguiti nel tempo,  la sua struttura organizzativa e gli strumenti di lavoro messi a disposizione.A conclusione verrà illustrata l’applicazione al caso concreto della costruzione del nuovo impianto di trattamento e recupero di rifiuti urbani.

  16. Pascoli e i ritorni di Ulisse

    OpenAIRE

    de Caprio, Vincenzo

    2010-01-01

    Lo studioso traccia le diverse articolazioni del mito di Ulisse, da Omero a Dante, fino a Pascoli, focalizzando in particolare l'attenzione sull'Ulisse pascoliano, ossia sui suoi tre testi odissiaci: "Il sonno di Ulisse", "Il ritorno" e "L'ultimo viaggio", raccolti nei "Poemi conviviali". Lo studioso illustra come, a proposito del mito di Ulisse, Pascoli sia stato intrigato non dal tema dell'erranza per mari e per popoli diversi, ma da quello del ritorno di Ulisse. Insomma a Pascoli sembra in...

  17. La poesia pensante di Lucio Saffaro

    Directory of Open Access Journals (Sweden)

    Paul Ricoeur

    2013-12-01

    Full Text Available Si presenta in queste pagine la prima traduzione italiana della prefazione che Paul Ricœur scrisse per il libro di poesie in prosa: L. Saffaro, Théorie de la poursuite, L’Alphée, Paris 1985. Il testo, pubblicato con l’autorizzazione del Fonds Ricœur, è impreziosito da grafiche di Lucio Saffaro, pubblicate con l’autorizzazione della Fondazione Lucio Saffaro.Il testo è inoltre corredato, a seguire, da un’introduzione di Gisella Vismara all’opera poetica, grafica e pittorica di Lucio Saffaro.

  18. La lirica dei putti danzanti di Aquileia.

    OpenAIRE

    Fontana, Federica

    2006-01-01

    Questa relazione esamina la rappresentazione di Cupidi trovata in un mosaico del quarto secolo ad Aquileia, in un’area situatat tra l’antico foro e il porto. Fontana sostiene che il mosaico, che rappresenta alcuni Cupidi alati incorniciati da una ghirlanda di fiori e folgie, potrebbe essere datato o al tempo dell’imperatore Costantino (mosaici simili sono stati rinvenuti nel palazzo di Costantino a Treviri) o al tempo di Costanzo II. In entrambi i casi, il mosaico e il palazzo al quale appart...

  19. Pantani di Marco Martinelli: una narrazione polifonica

    Directory of Open Access Journals (Sweden)

    Franco Nasi

    2014-05-01

    Full Text Available In questo articolo si analizza il testo drammaturgico Pantani di Marco Martinelli, una veglia epica teatrale di uno dei più noti eroi dello sport italiano degli ultimi anni. Il dramma rilegge anche la storia di Pantani e ricostruisce gli strani avvenimenti che portarono alla sospensione, alla estromissione del ciclista dal Giro d’Italia nel 1999, e in seguito alla sua profonda crisi psicologica e tragica morte in solitudine in un hotel, a soli 34 anni. Oltre alle modalità proprie della veglia rituale, il dramma utilizza anche i metodi del processo giudiziario, e offre testimonianze dettagliate che conducono a una riflessione critica sulla società italiana negli anni del potere politico di Berlusconi e della sua filosofia del consumismo. I tre diversi generi della retorica classica (epidittico, giudiziario e deliberativo si mescolano in questa complessa tessitura teatrale. Coniugando informazioni (processo e rito (veglia, Martinelli riesce a fondere la tragedia greca (forma mimetica e corale e il moderno teatro di narrazione (forma diegetica monologante. Combinando assieme scene intensamente drammatiche, ricordi di imprese sportive epiche, passaggi giocosi e parodici, e giustapponendo vari stili e registri (giornalistico, lirico, parodico, elegiaco, Martinelli crea momenti di forte “straniamento” e sorpresa, e rende particolarmente efficace il rito funebre, la ricostruzione storica della tragica vicenda di Pantani e la critica all’ideologia che ha dominato l’Italia negli anni di Berlusconi. 

  20. La sperimentazione antiplagio nella Facoltà di Economia di Rimini

    OpenAIRE

    Amoroso, Alessandro

    2012-01-01

    L'intervento presenterà i caratteri principali della sperimentazione antiplagio attuata nella Facoltà di Economia di Rimini sin dagli inizi del progetto di ateneo. Saranno illustrati brevemente la metodologia adottata e i risultati ottenuti. Concluderanno l'intervento alcune considerazioni sul plagio in ambito didattico e sugli strumenti utilizzati.

  1. Uso di stimatori per la valutazione dell'abbondanza di popolazioni campionate con metodi CMR

    Directory of Open Access Journals (Sweden)

    Luca Canova

    2003-10-01

    Full Text Available La stima dell'abbondanza di popolazione rappresenta un aspetto di fondamentale importanza ed elevata complessità nell'ecologia delle popolazioni animali. I metodi applicabili agli studi che prevedono cattura, marcatura e ricattura (CMR sono stati analizzati criticamente da Nichols e Pollock, i quali raccomandano l'adozione di stimatori basati su modelli probabilistici anziché i più diffusi metodi enumerativi. Scopo del presente lavoro è di confrontare le stime di abbondanza di popolazioni di Apodemus sylvaticus e Clethrionomys glareolus desunte da modelli probabilistici e relativi estimatori rispetto a metodi enumerativi quali il Minimum Number Alive (MNA. Fra il mese di aprile 2002 e febbraio 2003 le popolazioni di topo selvatico e arvicola rossastra sono state campionate mediante metodi CMR. L'area di studio è rappresentata dalla RN "Monticchie" di Somaglia (LO; la griglia di cattura era costituita da 98 trappole disposte a 10 m. Le trappole erano innescate con semi di girasole e controllate giornalmente. Gli individui catturati marcati e rilasciati dopo la raccolta di dati biometrici. I dati di popolazione sono stati elaborati adottando il "robust design" di Pollock. Il periodo di cattura è stato diviso in sessioni primarie (mesi e secondarie (settimane; Φ (sopravvivenza e N (abbondanza sono stati calcolati rispettivamente sulla base dei dati delle sessioni primarie e secondarie utilizzando i software Jolly e Capture. Stime indipendenti di N sono state ricavate da Jolly e applicando il MNA. L'analisi dei dati mostra che la precondizione di chiusura demografica delle popolazioni durante le sessioni secondarie di cattura è soddisfatta nell'82% dei casi. I modelli selezionati da Capture, e i relativi estimatori dell'abbondanza sono in prevalenza, per entrambe le specie, Mo (null e Mh (jackknife. Il confronto fra i modelli di tipo enumerativo e di tipo probabilistico dimostra che le stime di N ottenute mediante il primo

  2. Jasa SEO di Medan Berkualitas | Fajran 0853 6915 5314

    OpenAIRE

    fajran

    2015-01-01

    Kami penyedia jasa seo di medan yang berkualitas dalam pengerjaan, pelayanan untuk membantu anda. Menyediakan juga kursus, belajar, private seo di medan bagi anda yang ingin mempelajari tentang cara memunculkan bisnis anda di halaman pertama google.

  3. L’arte di vedere il mondo. Il nuovo realismo

    OpenAIRE

    Aleksandr Voronskij

    2014-01-01

    Traduzione italiana del saggio di Aleksandr Voronskij L’arte di vedere il mondo. Il nuovo realismo (Iskusstvo videt’ mir. Sbornik statej, 1928), a cura di Cinzia De Lotto e Adalgisa Mingati.  

  4. Attuare la pianificazione territoriale. Il Bilancio di attuazione 2012 delle previsioni del Piano Territoriale di Coordinamento Provinciale di Bologna

    Directory of Open Access Journals (Sweden)

    Alessandro Delpiano

    2013-06-01

    Full Text Available Il contributo, a distanza di quasi 10 anni dall’approvazione del Piano Territoriale di Coordinamento Provinciale, che conteneva direttive volte a contrastare la dispersione insediativa, propone un’analisi sugli obiettivi prefissati, con la valutazioni dei risultati raggiunti.

  5. Descrizione di un caso clinico di morbo coitale maligno (MCM in un focolaio di malattia in Italia

    Directory of Open Access Journals (Sweden)

    Massimo Scacchia

    2011-12-01

    Full Text Available In Italia, nel maggio 2011, in seguito a controlli effettuati su uno stallone per la relativa approvazione alla monta, è stato di nuovo segnalato il morbo coitale maligno (MCM. Nel lavoro viene descritto il caso di una cavalla con sintomi clinici della malattia ritenuta verosimilmente all’origine dell’infezione dello stallone.

  6. Pianificazione urbana e comportamenti di viaggio: più di una relazione

    Directory of Open Access Journals (Sweden)

    Elisabetta Vitale Brovarone

    2010-04-01

    Full Text Available L’influenza dei caratteri urbani sulla domanda di mobilità è un tema ampiamente dibattuto e studiato. Al di là delle assunzioni teoriche a riguardo, molti studiosi hanno tentato di individuare empiricamente nessi attestanti questo fenomeno. Gran parte della letteratura scientifica sul tema può essere ricondotta al dibattito sulla città compatta e sullo sprawl. Due principali obiettivi contraddistinguono questo dibattito: la comprensione delle complesse dinamiche che legano la domanda di mobilità ai caratteri urbani e l’individuazione di configurazioni sostenibili degli usi del suolo. Il fenomeno è dunque studiato al fine dello sviluppo di strategie fondate sull’integrazione tra i trasporti e gli usi del suolo, finalizzate a limitare l’uso dell’auto e ad ottenere una distribuzione modale degli spostamenti più equilibrata. Buona parte della ricerca scientifica, specialmente nell’ultimo decennio, è dunque focalizzata sull’identificazione di nessi causali tra gli usi del suolo e i trasporti, per supportare, o in alcuni casi mettere in discussione, esperienze e politiche integrate. Nonostante la quantità e varietà di studi dedicati al tema, il fenomeno è ancora lungi dall’essere compreso e dimostrato empiricamente. Il dibattito in proposito è ampio e l’impressione è che con l’aumentare degli studi in proposito e del livello di approfondimento delle analisi diminuisca la sensazione di chiarezza. Attraverso un’analisi della letteratura, l’articolo mette in evidenza i principali problemi emergenti dal dibattito. Senza negare l’importanza del riconoscimento di nessi causali tra i caratteri degli insediamenti e la domanda di mobilità, opinione di chi scrive è che l’individuazione di questi nessi non debba necessariamente costituire una condizione imprescindibile per la definizione e l’adozione di un approccio integrato.

  7. 40 CFR 721.3130 - Sulfuric acid, mono-C9-11-alkyl esters, sodium salts.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Sulfuric acid, mono-C9-11-alkyl esters... Specific Chemical Substances § 721.3130 Sulfuric acid, mono-C9-11-alkyl esters, sodium salts. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as...

  8. 76 FR 36349 - Diethylene Glycol MonoEthyl Ether (DEGEE); Exemption From the Requirement of a Tolerance

    Science.gov (United States)

    2011-06-22

    ... AGENCY 40 CFR Part 180 Diethylene Glycol MonoEthyl Ether (DEGEE); Exemption From the Requirement of a... establishes an exemption from the requirement of a tolerance for residues of Diethylene Glycol MonoEthyl Ether...) 305-5805. II. Petition for Exemption In the Federal Register of July 9, 2008 (73 FR 39291)...

  9. Three-Dimensional Analysis of dike/fault interaction at Mono Basin (California) using the Finite Element Method

    Science.gov (United States)

    La Marra, D.; Battaglia, M.

    2013-12-01

    Mono Basin is a north-trending graben that extends from the northern edge of Long Valley caldera towards the Bodie Hills and is bounded by the Cowtrack Mountains on the east and the Sierra Nevada on the west. The Mono-Inyo Craters volcanic chain forms a north-trending zone of volcanic vents extending from the west moat of the Long Valley caldera to Mono Lake. The Hartley Springs fault transects the southern Mono Craters-Inyo Domes area between the western part of the Long Valley caldera and June Lake. Stratigraphic data suggest that a series of strong earthquakes occurred during the North Mono-Inyo eruption sequence of ~1350 A.D. The spatial and temporal proximity between Hartley Springs Fault motion and the North Mono-Inyo eruption sequence suggests a possible relation between seismic events and eruptions. We investigate the interactions between slip along the Hartley Springs fault and dike intrusion beneath the Mono-Inyo craters using a three-dimensional finite element model of the Mono Basin. We employ a realistic representation of the Basin that includes topography, vertical and lateral heterogeneities of the crust, contact relations between fault planes, and a physical model of the pressure required to propagate the dike. We estimate (a) the distribution of Coulomb stress changes to study the influence of dike intrusion on Hartley Springs fault, and (b) the local stress and volumetric dilatation changes to understand how fault slip may influence the propagation of a dike towards the surface.

  10. EFISIENSI PERBANKAN SYARIAH DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Afif Amirillah

    2014-09-01

    Full Text Available This research aims to find out the factors that can cause the efficiency value difference of Islamic Banking in In-donesia. The data at this research is monetary data of Islamic Banking. It was obtained from Bank of Indonesia. Then, it was divided into input and output variables. The determination of input output variables at this research uses Value Added Approach. Its input output variables consist of Demand Deposits, Saving Deposits, Time Depo-sits, Paid -In Capital, Placement at Bank ofIndonesia, Inter Bank Assets, Mudharabah, Musyara kah, Murabahah, Istishna, Ijarahand Qardh. This research used Data Envelopment Analysis method. This method has a strength that is having the capability to measure inefficiency input output variables, so that, the variable can have the efficiency. This research has resulted Islamic Banking efficiency in Indonesia, but it does not include BPRS. The mean efficiency of Islamic banking in Indonesia is 99,94%. Penelitian ini bertujuan mencari faktor –faktor penyebab perbedaan nilai efisiensiperbankan syariah di Indo-nesia yang dibandingkan secara relatif untuk setiap periode. Data yang digunakan pada penelitian ini menggu-nakan data keuangan perbankan syariah yang diperoleh dari Bank Indonesia kemudian dibagi menjadi variabel input dan output. Penentuan variabel input dan output pada penelitian ini menggunakan pendekatan Value Added Approach. Variabel input outputnyaterdiri dari : Giro iB, Tabungan iB, Deposito iB, Modal disetor, Pen-empatan padaBank Indonesia, Penempatan pada bank lain, Mudharabah, Musyarakah, Murabahah,Istishna, Ijarah dan Qardh. Pada penelitian ini menggunakan metode Data Envelopment Analysis yang mempunyai kel-ebihan dalam menghitung efisiensi untuk setiap variabel input outputyang mengalami inefisiensi. Penelitian ini menghasilkan nilai efisiensi perbankan syariah di Indoenesia (tidak termasuk BPRS. Efisiensi perbankan syariah di Indonesia mengalami efisiensi rata-rata sebesar 99,94%.

  11. Un quaderno di qualitá

    Directory of Open Access Journals (Sweden)

    M.E. Damiani

    2003-05-01

    Full Text Available

    Obiettivo: sviluppare un sistema qualità per il Dipartimento di Sanità Pubblica, coerente con la politica aziendale, l’accreditamento regionale e le ISO Vision 2000, in cui il cuore è dato dal governo clinico, perseguendo obiettivi di salute e coniugando l’efficacia del sistema all’efficienza.

    Materiali e Metodi: attività di formazione intervento strutturata in corsi formativi ed incontri periodici indirizzati alla Direzione del Dipartimento, ai referenti Qualità individuati in ogni Servizio, oltre ad incontri di sensibilizzazione sul percorso con gli altri operatori del DSP.

    Risultati: sono stati definiti l’offerta di prodotti/servizi e dei relativi fattori qualitativi, i processi operativi (attività, responsabilità, strumenti e interfacce, il coinvolgimento della direzione (la politica e l’adesione al percorso, i sistemi di comunicazione (esterna ed interna, il sistema informativo per la verifica dei risultati, le modalità di realizzazione delle verifiche interne e del sistema informativo come supporto alle decisioni (il sistema informativo, la programmazione annuale ed il processo di budget. La realizzazione del testo “Quaderno di appunti sulla Qualità in Sanità” ha ulteriormente contribuito a diffondere agli operatori i fondamenti teorici del Sistema Qualità sviluppato, oltre alle tecniche e agli strumenti acquisiti.

    Conclusioni: il percorso ha portato a presidiare gli aspetti fondamentali del sistema organizzativo e a documentarne l’attività, ma anche ad individuare nuove criticità e opportunità di sviluppo: come la progettazione e l’utilizzo di sistemi informativiinformatici per la rilevazione dei dati e per la restituzione di informazioni gestionali, la necessità di un confronto maggiormente strutturato con l’utenza, di una verifica più approfondita dei risultati, mediante il riesame della

  12. Effect of fuel composition on poly aromatic hydrocarbons in particulate matter from DI diesel engine; Particulate chu no PAH ni oyobosu nenryo sosei no eikyo

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, S.; Tatani, T.; Yoshida, H.; Takizawa, H.; Miyoshi, K.; Ikebe, H. [COSMO Research Institute, Tokyo (Japan)

    1997-10-01

    The effect of fuel composition on poly aromatic hydrocarbons (PAH) in particulate matter from DI diesel engine was investigated by using deeply desulfurized fuel and model fuel which properties are not interrelated. It was found that the deeply desulfurized fuel have effect on reducing PAH emissions. Furthermore, it was suggested that poly aromatics in the fuel affect PAH emissions and the influence of tri-aromatics in the fuel was promoted by the coexistence of mono-aromatics or naphthene. PAH formation scheme from each fuel component was proposed by chemical thermodynamic data. 4 refs., 8 figs., 3 tabs.

  13. Neuropsicologia, le novità dal congresso Sinp di Roma

    OpenAIRE

    Marco Mozzoni

    2012-01-01

    Tutte le novità su mente e cervello dal congresso annuale della Società Italiana di Neuropsicologia (Sinp 2012) tenutosi lo scorso Novembre presso la Fondazione Santa Lucia di Roma presentate su BrainFactor in uno "speciale" realizzato dagli studenti del Laboratorio di Comunicazione giornalistica dell'Università degli Studi di Milano Bicocca. Memoria, percezione, linguaggio, semantica, afasie, sclerosi multipla, disordini di coscienza, stato vegetativo, stato di minima coscienza, Alzheimer, d...

  14. Sul comportamento post critico di pannelli in vetro stratificato

    OpenAIRE

    Silvestri, Mirko

    2009-01-01

    La tesi di dottorato ha come oggetto principale lo studio e la caratterizzazione del comportamento a flessione di elementi strutturali in vetro stratificato. La progettazione di tali elementi è particolarmente delicata e richiede estrema cura perché la struttura è soggetta al rischio di rotture fragili, sia causate da possibili difetti presenti nel materiale vetro, sia da impatti accidentali anche di lieve entità. Nel lavoro di tesi l’attenzione viene focalizzata soprattutto sul comportamento...

  15. RIVESTIMENTI TERMOSPRUZZATI PER BARRIERE TERMICHE DI NUOVA CONCEZIONE

    OpenAIRE

    Marra, Francesco

    2013-01-01

    Nel progetto di Dottorato presentato è stata ideata e presentata una innovativa configurazione multistrato di TPS di questo tipo, potenzialmente idonea sia ad un’applicazione in ambito propulsivo (rivestimento di palettature di turbine, camere di combustione, ugelli), sia come protezione termica per veicoli da rientro riutilizzabili. L’articolazione concettuale del lavoro è riassunta nello schema seguente: i.) dapprima una fase preliminare volta a verificare la realizzabilità del sistema idea...

  16. EKONOMI PEKARANGAN DI PEDESAAN JAWA

    Directory of Open Access Journals (Sweden)

    Dede Mulyanto

    2013-04-01

    Full Text Available Tujuan artikel ini adalah untuk menganalisa peran pekarangan sebagai sumber ketersediaan pangan, energi rumahtangga, dan uang tunai bagi rumahtangga petani. Bagi orang Jawa lahan tidak hanya tempat bekerja mereka tetapi sebagai sebuah status sosial, ekoncomi dan politik di masyarakat. Disinilah pekarangan, sebuah lahan kecil di rumah, mengambil peran ketika petani menghadapai kesulitan ekonomi yang dikarenakan lahan garapannya tidak menguntungkan. Rumusan masalahnya adalah bagaimana karakteristik desa Wetankali dan bagaimana bentuk pemanfaatan ekonomi pekarangan yang terjadi di sana. Metode penelitian yang digunakan adalah etnografis disertai survei dengan kuisioner dan analisis data sekunder. Penelitian ini dilakukan di Desa Wetankali Kecamatan Kutocilik Kabupaten Banyumas. Pekarangan bagi masyarakat Jawa merupakan benteng yang dengannya mereka dapat bertahan hidup. Pekarangan ditanami beberapa jenis tanaman ynag dapat dijual untuk menambah pendapatan rumahtangga petani. Bersaamaan dengan pertumbuhan penduduk yang naik, pekarangan berubah bentuk menjadi semakin sempit karena masyarakat lebih memilih menggunakan lahannya untuk hunian. Akibatnya, untuk rumahtangga miskin, sumber makanan pendukung dan energi murah mulai menghilang. The objective of this article is to analyse the role played by house yards or home garden as source of food storage, household energy, and cash for peasant household. For Javanese peasant, yard was not only a  place for work, but also a space to represent economy and social status. The importance of house yards is felt in difficult situation such as economic crises and corpse failure. Research questions in this anysisis are how about the characteristics of Wetankali village and how about the pattern of using home garden or home yard there. Research method used is etnography with survey using questionaire and secondary data analysis. The research was conducted in Watankali, Kutocilik Banyumas. For Javanese, yards

  17. Comportamento a fatica dei giunti saldati in funzione della densità di energia di deformazione locale: influenza dei campi di tensione singolari e non singolari

    Directory of Open Access Journals (Sweden)

    Paolo Lazzarin

    2009-07-01

    Full Text Available Il criterio della densità di energia di deformazione (SED considera un preciso volume di controllo posizionato in corrispondenza del piede o della radice dei cordoni di saldatura, ossia delle zone di possibileinnesco delle cricche di fatica. Modellati i cordoni come intagli a V non raccordati e con diverso angolo di apertura, il volume è riconducibile a un settore circolare nei casi di tensione o deformazione piana, e il raggio vale circa 0.3 mm per i giunti saldati in acciaio strutturale.Il valore medio della densità di energia di deformazione dipende essenzialmente dalle distribuzioni singolari nei giunti di medio ed elevato spessore, mentre importante diventa il contributo della T-stress nei giunti di spessore ridotto. Entrambi gli effetti sono correttamente computati utilizzando modelli agli elementi finiti, anche utilizzando mesh con un numero ridotto di gradi di libertà. Il fatto è di notevole interesse per una possibile applicazione del metodo a strutture saldate di geometria complessa. Agli effetti descritti, tipicamente riconducibili a una modellazione piana, si possono accompagnare campi singolari non convenzionali, legati aeffetti tridimensionali indotti dalla geometria. L’effetto out-of-plane è qui evidenziato in relazione ai giunti a semplice sovrapposizione.

  18. Il concetto di storia della lingua nell'opera grammaticale di Benedetto Buommattei

    Directory of Open Access Journals (Sweden)

    Gunver Skytte

    1991-12-01

    Full Text Available Che la storia della lingua sia una disciplina linguistica di data recente, fondata nell'800, soprattutto grazie alle ricerche pionieristiche di insigni filologi tedeschi, è un'opinione comunemente accettata, ed essa è probabilmente anche giustificata attraverso la classificazione datane di disciplina. A questo dato di fatto si deve senz'altro l'opinione altrettanto estesa che prima dell'800 non esistesse il concetto di linguistica diacronica o cambiamento linguistico in senso scientifico, come pure quella non meno erronea che la linguistica, come scienza, sia stata fondata solo nell'800.

  19. D. Felini (a cura di, Video game education. Studi e percorsi di formazione

    Directory of Open Access Journals (Sweden)

    Alex Tribelli

    2013-03-01

    Full Text Available Nei confronti di una trattazione scientifica dei videogame c’è tuttora qualche scetticismo. I pregiudizi, più volte denunciati, ancora hanno qualche sussistenza: persiste qualche analisi sociale che considera i videogame oggetti diabolici che provocano isolamento e comportamenti violenti nei teenager. Pur constatando una progressiva inversione di tendenza, Video game education. Studi e percorsi di formazione, curato da Damiano Felini, si propone di sgretolare la concezione che la società contemporanea ha dei videogame, dimostrando come questi oggetti mediali possono addirittura divenire uno strumento di formazione e crescita delle persone.

  20. Gli insediamenti minori romani in area alpina orientale : Il caso di Castelraimondo di Forgaria nel Friuli

    OpenAIRE

    Cavalieri, Marco

    2002-01-01

    L'articolo fa riferimento agli scavi del sito minore alpino di Castelraimondo (provincia d'Udine, Friuli-Venezia Giulia) in merito alla sua lunga continuità di vita da centro alpino di cultura celtica fino alle fasi di romanizzazione, alla sua trasformazione in refugium durante la tarda antichità ed all'abbandono durante il Medioevo (dal IV sec. a.C. al XIV d.C). Il tema dell'acculturazione e della romanizzazione sono calati nell'ambito di un quadro archeologico preciso e scavato per diversi ...

  1. Il "Sogno" di un collezionista del Seicento napoletano. Maurizio Di Gregorio tra riscrittura e plagio

    OpenAIRE

    Daniela Caracciolo

    2011-01-01

    Nel 1614 escono a Napoli il Sogno e il Rosario delle stampe de tutti i poeti e poetesse antichi e moderni di numero 500 del domenicano e accademico ozioso Maurizio Di Gregorio. Il saggio prende in esame le strategie di riscrittura che sorreggono per intero la struttura dell'opera dove i testi di autori più o meno contemporanei (Tommaso Garzoni, Giovan Battista Rinaldi) sono sottoposti a un intenso lavoro di aggiornamento. L'analisi si concentra in particolar modo sui prelievi che nel Sogno ve...

  2. Il modello di Museo Virtuale dell’Educazione dell’Università di Bologna

    Directory of Open Access Journals (Sweden)

    Chiara Panciroli

    2010-07-01

    Full Text Available La relazione dal titolo “Studi per un modello di Museo dell’Educazione virtuale dell’Università di Bologna”, facendo riferimento agli sviluppi del museo a livello europeo ed extraeuropeo, con un approfondimento specifico alla realtà italiana, cerca di coniugare gli elementi della museologia con alcuni dei modelli interpretativi pedagogici al fine di definire alcuni percorsi didattici museali in rete, che sappiano cogliere le innovazioni che provengono dall’ambito tecnologico ma rivisitate alla luce di caratteristiche educative e formative irrinunciabili.

  3. Il libro di spese diverse di Lorenzo Lotto. Analisi e commento

    OpenAIRE

    De Carolis, Francesco

    2015-01-01

    Il progetto si concentra sull’analisi ed il commento del libro dei conti di Lorenzo Lotto. Esso viene conservato nell’Archivio storico della Santa Casa di Loreto, ed è meglio conosciuto con il nome apocrifo di Libro di spese diverse. Possiamo considerarlo uno dei più significativi documenti del Rinascimento italiano: infatti esso ci parla dei rapporti che l’artista ha intessuto con committenti, colleghi ed amici, rivelando tanto la sua condotta di vita che la sua attività. È una ricerca che t...

  4. H-Star di Trimble Un sistema GPS in doppia frequenza per rilievi di alta precisione

    OpenAIRE

    Redazione Redazione

    2005-01-01

    L’acquisizione dati con H-Star è gestita con un software specificatamente ideato per i dati di elevata accuratezza. Esso, dotato di indicatore Predicted PostprocessedAccuracy (PPA), mostra chiaramente la precisione che si otterrà una volta che i dati H-Star verranno postprocessati. L’elaborazione di questi dati è studiata appositamente per raggiungere una precisione superiore ai 30 cm con non più di due minuti di dati continui.

  5. H-Star di Trimble Un sistema GPS in doppia frequenza per rilievi di alta precisione

    Directory of Open Access Journals (Sweden)

    Redazione Redazione

    2005-10-01

    Full Text Available L’acquisizione dati con H-Star è gestita con un software specificatamente ideato per i dati di elevata accuratezza. Esso, dotato di indicatore Predicted PostprocessedAccuracy (PPA, mostra chiaramente la precisione che si otterrà una volta che i dati H-Star verranno postprocessati. L’elaborazione di questi dati è studiata appositamente per raggiungere una precisione superiore ai 30 cm con non più di due minuti di dati continui.

  6. The effect of trace element addition to mono-digestion of grass silage at high organic loading rates.

    Science.gov (United States)

    Wall, David M; Allen, Eoin; Straccialini, Barbara; O'Kiely, Padraig; Murphy, Jerry D

    2014-11-01

    This study investigated the effect of trace element addition to mono-digestion of grass silage at high organic loading rates. Two continuous reactors were compared. The first mono-digested grass silage whilst the second operated in co-digestion, 80% grass silage with 20% dairy slurry (VS basis). The reactors were run for 65weeks with a further 5weeks taken for trace element supplementation for the mono-digestion of grass silage. The co-digestion reactor reported a higher biomethane efficiency (1.01) than mono-digestion (0.90) at an OLR of 4.0kgVSm(-3)d(-1) prior to addition of trace elements. Addition of cobalt, iron and nickel, led to an increase in the SMY in mono-digestion of grass silage by 12% to 404LCH4kg(-1)VS and attained a biomethane efficiency of 1.01. PMID:25280042

  7. Synthesis of lanthanum tris (mono-i-octyl phthalate)and its thermal stability for polyvinyl chloride

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A novel type of thermal stabilizer-lanthanum tris (mono-i-octyl phthalate) (LTMP) was synthesized by double-decomposition reaction of sodium mono-i-octyl phthalate with lanthanum chloride at 60℃.Sodium mono-i-octyl phthalate was prepared by sodium hydrate and mono-i-octyl phthalate prepared by reaction of isooctyl alcohol and phthalic anhydride in the presence of sulfuric acid catalyst at 110 ℃. The yield of lanthanum tris (mono-i-octyl phthalate) is about 84.5%. Its thermal stabilities were measured by heat-ageing oven test when incorporated into PVC. The experimental results show that the heat stability time is about 40min at 190 ℃ when adding 3phr (per hundred resin) to PVC. The thermal stability of this product is better than that of Ca-Zn complex and basic lead salt stabilizers, and equal to that of dibutyltin dilaurate.

  8. Critical evaluation of polychlorinated biphenyl toxicity in terrestrial and marine mammals: increasing impact of non-ortho and mono-ortho coplanar polychlorinated biphenyls from land to ocean.

    Science.gov (United States)

    Kannan, N; Tanabe, S; Ono, M; Tatsukawa, R

    1989-11-01

    Residues of potentially toxic non-ortho chlorine substituted coplanar 3,3',4,4'-tetra-,3,3',4,4',5-penta-, 3,3',4,4',5,5'-hexachlorobiphenyl and their mono- and di-ortho analogs 2,3',4,4',5-penta, 2,3,3',4,4'-penta-, 2,3,3',4,4',5-hexa- and 2,2',3,3',4,4'-hexa-, 2,2',3,4,4',5-hexachlorobiphenyl) were determined in humans, dogs, cats (terrestrial), a finless porpoise (Neophocoena phocoenoides--coastal), Dall's porpoises (Phocoenoides dalli, dalli), Baird's beaked whales (Berardius bairdii) and killer whales (Orcinus orca--open ocean). Among the coplanar polychlorinated biphenyl (PCB) congeners, the concentration of the di-ortho congeners was the highest and the non-ortho congeners was the lowest. However, all three coplanar PCBs occurred at significantly higher levels than toxic polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). The relative bioconcentration and metabolic capacity of terrestrial and marine mammals to these chemicals, suggest that the toxic threat of coplanar PCBs increases from land to ocean, but the reverse is true for PCDDs and PCDFs. The toxic threat of coplanar PCBs to higher aquatic predators such as cetaceans was principally assessed by 2,3,7,8-T4CDD Toxic Equivalent Analysis which is based on the induction of arylhydrocarbon hydroxylase (AHH) and ethoxyresorufin O-deethylase (EROD). Analysis indicates, in particular, that the bioaccumulation of toxic 3,3',4,4',5-penta- and 2,3,3',4,4'-pentachlorobiphenyls in carnivorous marine mammals is a cause for considerable concern. PMID:2515809

  9. One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX

    Directory of Open Access Journals (Sweden)

    Stöcklein Walter

    2007-08-01

    Full Text Available Abstract Background As a new class of therapeutic and diagnostic reagents, more than fifteen years ago RNA and DNA aptamers were identified as binding molecules to numerous small compounds, proteins and rarely even to complete pathogen particles. Most aptamers were isolated from complex libraries of synthetic nucleic acids by a process termed SELEX based on several selection and amplification steps. Here we report the application of a new one-step selection method (MonoLEX to acquire high-affinity DNA aptamers binding Vaccinia virus used as a model organism for complex target structures. Results The selection against complete Vaccinia virus particles resulted in a 64-base DNA aptamer specifically binding to orthopoxviruses as validated by dot blot analysis, Surface Plasmon Resonance, Fluorescence Correlation Spectroscopy and real-time PCR, following an aptamer blotting assay. The same oligonucleotide showed the ability to inhibit in vitro infection of Vaccinia virus and other orthopoxviruses in a concentration-dependent manner. Conclusion The MonoLEX method is a straightforward procedure as demonstrated here for the identification of a high-affinity DNA aptamer binding Vaccinia virus. MonoLEX comprises a single affinity chromatography step, followed by subsequent physical segmentation of the affinity resin and a single final PCR amplification step of bound aptamers. Therefore, this procedure improves the selection of high affinity aptamers by reducing the competition between aptamers of different affinities during the PCR step, indicating an advantage for the single-round MonoLEX method.

  10. Synthesis and photochromic behavior of mono-,and biphotochromic system linked by p-phenylene bridge

    Institute of Scientific and Technical Information of China (English)

    N.O.Mahmoodi; K.Tabatabaeian; A.Ghavidast

    2010-01-01

    The synthesis of mono- and bis-1,3-diazabicyclo[3.1.0]hex-3-ene derivatives with indole ring and p-phenylene spacer,which behave as photochromic materials,is reported.The structure-photochromic behavior relationship (SPBR) of the synthesized compounds has been analyzed.

  11. Endotoxin testing of proteins for parenteral administration using the Mono Mac 6 assay

    DEFF Research Database (Denmark)

    Moesby, Lise; Hansen, E W; Christensen, J D

    2000-01-01

    Pharmaceutical products containing proteins cause problems in testing for endotoxin and pyrogens. Many proteins interfere with the LAL test and the proteins are immunogenic in rabbits. The monocytic cell line Mono Mac 6 is an alternative assay for detection of endotoxin and other pyrogens....

  12. DEVELOPMENTAL NEUOTOXICITY EVALUATION OF MIXTURES OF MONO- AND DIMETHYL TIN IN DRINKING WATER OF RATS.

    Science.gov (United States)

    Developmental Neurotoxicity Evaluation of Mixtures of Mono- and Dimethyl Tin in Drinking Water of RatsV.C. Moser, K.L. McDaniel, P.M. PhillipsNeurotoxicology Division, NHEERL, ORD, US EPA, RTP, NC, USAOrganotins, especially monomethyl (MMT) and dimethyl (D...

  13. Synthesis of hierarchical zeolites using an inexpensive mono-quaternary ammonium surfactant as mesoporogen.

    Science.gov (United States)

    Zhu, Xiaochun; Rohling, Roderigh; Filonenko, Georgy; Mezari, Brahim; Hofmann, Jan P; Asahina, Shunsuke; Hensen, Emiel J M

    2014-12-01

    A simple amphiphilic surfactant containing a mono-quaternary ammonium head group (N-methylpiperidine) is effective in imparting substantial mesoporosity during synthesis of SSZ-13 and ZSM-5 zeolites. Highly mesoporous SSZ-13 prepared in this manner shows greatly improved catalytic performance in the methanol-to-olefins reaction compared to bulk SSZ-13. PMID:25316609

  14. Maillard reaction products of rice protein hydrolysates with mono-, oligo- and polysaccharides

    Science.gov (United States)

    Rice protein, a byproduct of rice syrup production, is abundant but, its lack of functionality prevents its wide use as a food ingredient. Maillard reaction products of (MRPs) hydrolysates from the limited hydrolysis of rice protein (LHRP) and various mono-, oligo- and polysaccharides were evaluat...

  15. Emotions in freely varying and mono-pitched vowels, acoustic and EGG analyses.

    Science.gov (United States)

    Waaramaa, Teija; Palo, Pertti; Kankare, Elina

    2015-12-01

    Vocal emotions are expressed either by speech or singing. The difference is that in singing the pitch is predetermined while in speech it may vary freely. It was of interest to study whether there were voice quality differences between freely varying and mono-pitched vowels expressed by professional actors. Given their profession, actors have to be able to express emotions both by speech and singing. Electroglottogram and acoustic analyses of emotional utterances embedded in expressions of freely varying vowels [a:], [i:], [u:] (96 samples) and mono-pitched protracted vowels (96 samples) were studied. Contact quotient (CQEGG) was calculated using 35%, 55%, and 80% threshold levels. Three different threshold levels were used in order to evaluate their effects on emotions. Genders were studied separately. The results suggested significant gender differences for CQEGG 80% threshold level. SPL, CQEGG, and F4 were used to convey emotions, but to a lesser degree, when F0 was predetermined. Moreover, females showed fewer significant variations than males. Both genders used more hypofunctional phonation type in mono-pitched utterances than in the expressions with freely varying pitch. The present material warrants further study of the interplay between CQEGG threshold levels and formant frequencies, and listening tests to investigate the perceptual value of the mono-pitched vowels in the communication of emotions. PMID:24998780

  16. Mono- and bis(pyrrolo)tetrathiafulvalene derivatives tethered to C60

    DEFF Research Database (Denmark)

    Vico Solano, Marta; Della Pia, Eduardo Antonio; Jevric, Martyn; Schubert, Christina; Wang, Xintai; van der Pol, Cornelia; Kadziola, Anders; Nørgaard, Kasper; Guldi, Dirk M.; Nielsen, Mogens Brøndsted; Jeppesen, Jan Oskar

    2014-01-01

    A series of mono- (MPTTF) and bis(pyrrolo) tetrathiafulvalene (BPTTF) derivatives tethered to one or two C-60 moieties was synthesized and characterized. The synthetic strategy for these dumbbell-shaped compounds was based on a 1,3-dipolar cycloaddition reaction between aldehyde-functionalized MP...

  17. The Effects of Operational Parameters on a Mono-wire Cutting System: Efficiency in Marble Processing

    Science.gov (United States)

    Yilmazkaya, Emre; Ozcelik, Yilmaz

    2016-02-01

    Mono-wire block cutting machines that cut with a diamond wire can be used for squaring natural stone blocks and the slab-cutting process. The efficient use of these machines reduces operating costs by ensuring less diamond wire wear and longer wire life at high speeds. The high investment costs of these machines will lead to their efficient use and reduce production costs by increasing plant efficiency. Therefore, there is a need to investigate the cutting performance parameters of mono-wire cutting machines in terms of rock properties and operating parameters. This study aims to investigate the effects of the wire rotational speed (peripheral speed) and wire descending speed (cutting speed), which are the operating parameters of a mono-wire cutting machine, on unit wear and unit energy, which are the performance parameters in mono-wire cutting. By using the obtained results, cuttability charts for each natural stone were created on the basis of unit wear and unit energy values, cutting optimizations were performed, and the relationships between some physical and mechanical properties of rocks and the optimum cutting parameters obtained as a result of the optimization were investigated.

  18. Production of pulse in mono-cropped rice system in the coastal region of Eastern India

    International Nuclear Information System (INIS)

    This experiment was undertaken with an objective to increase the yield of black-gram leguminous pulse crop through optimal doses of phosphatic fertilizer with supplemental irrigation in mono-cropped rice-fallow regions of India. Irrigation and phosphorus fertilizer application were introduced for enhancing productivity of black-gram to provide better returns to available water resources

  19. Simulazione della propagazione di difetti a fatica mediante il modello di zona coesiva

    Directory of Open Access Journals (Sweden)

    A.Pirondi, F.Moroni

    2009-07-01

    Full Text Available Le giunzioni incollate guadagnano sempre più mercato, nel campo delle costruzioni in genere, dove è necessario un alleggerimento delle strutture. Nel caso di geometrie di giunto semplici il dimensionamento avviene attraverso relazioni analitiche che restituiscono il valore massimo delle tensioni, il quale deve essere inferiore al limite di utilizzo dell’adesivo stesso. Quando le geometrie sono complesse l’approccio analitico diventa impraticabile, di conseguenza si provvede a verificare la correttezza della soluzione mediante analisi agli elementi finiti (EF. L’introduzione del modello di zona coesiva nell'analisi EF permette di simulare il danneggiamento ed il cedimento del giunto in condizioni quasi-statiche e impulsive. In questo articolo si vuole implementare il modello per la simulazione della propagazione a fatica di difetti, utilizzando il software agli elementi finiti ABAQUS assieme a subroutine esterne interagenti con il modello EF stesso. Un punto focale dell'implementazione sarà il calcolo automatico del tasso di rilascio di energia G in modo indipendente dalla geometria del difetto stesso. I parametri del modello ricavati da prove di tenacità a frattura e propagazione di difetti a fatica in modo I, saranno utilizzati come riferimento per la convalida dell'implementazione.

  20. Castelli di carta. La piega per la costruzione di superfici articolate

    Directory of Open Access Journals (Sweden)

    Andrea Casale

    2012-06-01

    Full Text Available L’antica arte del piegare la carta, l’Origami, sta vivendo un rinnovato interesse che coinvolge molti aspetti della ricerca.  Con il termine origami, si intende lo studio del modo di piegare il foglio di carta per imporgli una specifica forma.  La superficie tassellata per mezzo di specifiche pieghe, si propone come un nuovo soggetto di studio: la superficie piegata articolata. La forma congiunta al movimento, assume un particolare interesse nella contemporanea ricerca geometrica e architettonica. Il panorama contemporaneo, propone opere di architettura “responsiva”, capaci di modificare le proprie caratteristiche per adeguarsi a nuove condizioni. La superficie piegata articolata sembra particolarmente adatta a descrivere questo modo d’intendere l’architettura, reagendo a diverse volontà e di conseguenza modificando la propria conformazione attraverso un attento controllo progettuale della forma.