WorldWideScience

Sample records for ali

  1. ALIS deployment in Cambodia

    Science.gov (United States)

    Sato, Motoyuki; Takahashi, Kazunori

    2012-06-01

    Dual sensor is one of the most promising sensors for humanitarian demining operations. Conventional landmine detection depends on highly trained and focused human operators manually sweeping 1m2 plots with a metal detector and listening for characteristic audio signals indicating the presence of AP (Anti-personnel) landmines. In order to reduce the time of plodding detected objects, metal detectors need to be combined with a complimentary subsurface imaging sensor. i.e., GPR(Ground Penetrating Radar). The demining application requires real-time imaging results with centimetre resolution in a highly portable package. We are currently testing a dual sensor ALIS which is a real-time sensor tracking system based on a CCD camera and image processing. In this paper we introduce ALIS systems which we have developed for detection of buried antipersonnel mines and small size explosives. The performance of ALIS has been tested in Cambodia since 2009. More than 80 anti-personnel mines have been detected and removed from local agricultural area. ALIS has cleared more than 70,000 m2 area and returned it to local farmers.

  2. Tibet's Ali: Asia's Atacama?

    CERN Document Server

    Ye, Quan-Zhi; Li, Hong; Zhang, Xinmin

    2015-01-01

    The Ngari (Ali) prefecture of Tibet, one of the highest areas in the world, has recently emerged as a promising site for future astronomical observation. Here we use 31 years of reanalysis data from the Climate Forecast System Reanalysis (CFSR) to examine the astroclimatology of Ngari, using the recently-erected Ali Observatory at Shiquanhe (5~047~m above mean sea level) as the representative site. We find the percentage of photometric night, median atmospheric seeing and median precipitable water vapor (PWV) of the Shiquanhe site to be $57\\%$, $0.8"$ and 2.5~mm, comparable some of the world's best astronomical observatories. Additional calculation supports the Shiquanhe region as one of the better sites for astronomical observations over the Tibetan Plateau. Based on the studies taken at comparable environment at Atacama, extraordinary observing condition may be possible at the few vehicle-accessible 6~000~m heights in the Shiquanhe region. Such possibility should be thoroughly investigated in future.

  3. AliEn Resource Brokers

    OpenAIRE

    Saiz, Pablo; Buncic, Predrag; Peters, Andreas J.

    2003-01-01

    AliEn (ALICE Environment) is a lightweight GRID framework developed by the Alice Collaboration. When the experiment starts running, it will collect data at a rate of approximately 2 PB per year, producing O(109) files per year. All these files, including all simulated events generated during the preparation phase of the experiment, must be accounted and reliably tracked in the GRID environment. The backbone of AliEn is a distributed file catalogue, which associates universal logical file name...

  4. AliEn Resource Brokers

    CERN Document Server

    Saiz, P; Peters, A J; Saiz, Pablo; Buncic, Predrag; Peters, Andreas J.

    2003-01-01

    AliEn (ALICE Environment) is a lightweight GRID framework developed by the Alice Collaboration. When the experiment starts running, it will collect data at a rate of approximately 2 PB per year, producing O(109) files per year. All these files, including all simulated events generated during the preparation phase of the experiment, must be accounted and reliably tracked in the GRID environment. The backbone of AliEn is a distributed file catalogue, which associates universal logical file name to physical file names for each dataset and provides transparent access to datasets independently of physical location. The file replication and transport is carried out under the control of the File Transport Broker. In addition, the file catalogue maintains information about every job running in the system. The jobs are distributed by the Job Resource Broker that is implemented using a simplified pull (as opposed to traditional push) architecture. This paper describes the Job and File Transport Resource Brokers and sho...

  5. Effects of Splenectomy on Spontaneously Chronic Pancreatitis in aly/aly Mice

    Directory of Open Access Journals (Sweden)

    Heng-Xiao Wang

    2010-01-01

    Full Text Available Background and Aim. Mice with alymphoplasia (aly/aly mutation characterized by a lack of lymph nodes, Peyer's patches, and well-defined lymphoid follicles in the spleen were found. In this study, we used splenectomized aly/aly mice to elucidate the effects of secondary lymphoid organs in the development of aly/aly autoimmune pancreatitis. Methods. Forty-eight 10-week-old aly/aly mice were divided into two groups for splenectomy and sham operation. Histological and immunohistochemical analyses of the pancreas were performed at the ages of 20, 30, and 40 weeks old after operation, respectively. Results. Our results showed that mononuclear cell infiltration was restricted to the interlobular connective tissues at the age of 20 weeks, and not increase obviously at the age of 30 and 40 weeks in splenectomized aly/aly mice. Furthermore, an apparent decrease in the expressions of CD4+ T, CD8+ T, and B cells was detected in the pancreatic tissues compared with sham aly/aly mice, however, no significant difference in macrophage expression between mice with and without a splenectomy. Conclusions. Inflammation infiltration and development of the pancreatitis in aly/aly mice were suppressed effectively after splenectomy, which was, at least partly, correlated to inhibition of the infiltration of T and B cells in pancreatic tissues but not to macrophages.

  6. AliEn - EDG Interoperability in ALICE

    OpenAIRE

    Bagnasco, S.; Barbera, R; Buncic, P.; Carminati, F.; Cerello, P.; Saiz, P.

    2003-01-01

    AliEn (ALICE Environment) is a GRID-like system for large scale job submission and distributed data management developed and used in the context of ALICE, the CERN LHC heavy-ion experiment. With the aim of exploiting upcoming Grid resources to run AliEn-managed jobs and store the produced data, the problem of AliEn-EDG interoperability was addressed and an in-terface was designed. One or more EDG (European Data Grid) User Interface machines run the AliEn software suite (Cluster Monitor, Stora...

  7. AliEn - EDG Interoperability in ALICE

    CERN Document Server

    Bagnasco, S; Buncic, P; Carminati, F; Cerello, P G; Saiz, P

    2003-01-01

    AliEn (ALICE Environment) is a GRID-like system for large scale job submission and distributed data management developed and used in the context of ALICE, the CERN LHC heavy-ion experiment. With the aim of exploiting upcoming Grid resources to run AliEn-managed jobs and store the produced data, the problem of AliEn-EDG interoperability was addressed and an in-terface was designed. One or more EDG (European Data Grid) User Interface machines run the AliEn software suite (Cluster Monitor, Storage Element and Computing Element), and act as interface nodes between the systems. An EDG Resource Broker is seen by the AliEn server as a single Computing Element, while the EDG storage is seen by AliEn as a single, large Storage Element; files produced in EDG sites are registered in both the EDG Replica Catalogue and in the AliEn Data Catalogue, thus ensuring accessibility from both worlds. In fact, both registrations are required: the AliEn one is used for the data management, the EDG one to guarantee the integrity and...

  8. ALIED: A Theory of Lie Detection

    Directory of Open Access Journals (Sweden)

    Chris N. H. Street

    2016-07-01

    Full Text Available We are very inaccurate lie detectors, and tend to believe what others tell us is the truth more often than we ought to. In fact, studies on lie detection typically describe our tendency to believe others as an error in judgment. Although people may look like hopeless lie detectors, the Adaptive Lie Detector theory (ALIED claims that people are actually making smart, informed judgments. This article explores the ALIED theory and what it means for those wanting to spot a liar.

  9. AliEnFS - a Linux File System for the AliEn Grid Services

    CERN Document Server

    Peters, A J; Buncic, P; Peters, Andreas J.

    2003-01-01

    Among the services offered by the AliEn (ALICE Environment http://alien.cern.ch) Grid framework there is a virtual file catalogue to allow transparent access to distributed data-sets using various file transfer protocols. $alienfs$ (AliEn File System) integrates the AliEn file catalogue as a new file system type into the Linux kernel using LUFS, a hybrid user space file system framework (Open Source http://lufs.sourceforge.net). LUFS uses a special kernel interface level called VFS (Virtual File System Switch) to communicate via a generalised file system interface to the AliEn file system daemon. The AliEn framework is used for authentication, catalogue browsing, file registration and read/write transfer operations. A C++ API implements the generic file system operations. The goal of AliEnFS is to allow users easy interactive access to a worldwide distributed virtual file system using familiar shell commands (f.e. cp,ls,rm ...) The paper discusses general aspects of Grid File Systems, the AliEn implementation...

  10. AliEnFS - a Linux File System for the AliEn Grid Services

    OpenAIRE

    Peters, Andreas J.; Saiz, P.; Buncic, P.

    2003-01-01

    Among the services offered by the AliEn (ALICE Environment http://alien.cern.ch) Grid framework there is a virtual file catalogue to allow transparent access to distributed data-sets using various file transfer protocols. $alienfs$ (AliEn File System) integrates the AliEn file catalogue as a new file system type into the Linux kernel using LUFS, a hybrid user space file system framework (Open Source http://lufs.sourceforge.net). LUFS uses a special kernel interface level called VFS (Virtual F...

  11. Muhammad Ali, um outsider na sociedade americana?

    Directory of Open Access Journals (Sweden)

    Flávio Py Mariante Neto

    2010-12-01

    Full Text Available O estudo analisa a carreira do boxeador Muhammad Ali segundo as formulações sobre as relações de poder em configurações apresentadas por Norbert Elias. O propósito foi compreender como um atleta que foi contra questões tão profundas da sociedade estabelecida obteve sucesso profissional. Tratou-se de um estudo documental, tendo como fonte livros, artigos e reportagens publicadas sobre a trajetória do lutador. Concluiu-se que apesar de Ali ter se posicionado contra padrões estabelecidos de sua época em questões como a religião, o racismo e o patriotismo, a sua habilidade técnica acima da média, o seu poder de autopromoção e a sua capacidade de participar do jogo no contexto configuracional de que fazia parte, lhe deram condições de sobrevivência no mundo do boxe e conseqüente sucesso profissional.

  12. Analysis list: aly-2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available aly-2 Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/aly-2.1....tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/aly-2.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/al...y-2.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/aly-2.Larvae.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

  13. AliEn: ALICE environment on the GRID

    Energy Technology Data Exchange (ETDEWEB)

    Bagnasco, S; Betev, L; Buncic, P; Carminati, F; Cirstoiu, C; Grigoras, C; Hayrapetyan, A; Harutyunyan, A; Peters, A J; Saiz, P [CERN, European Organization for Nuclear Research, 1211 Geneve 23 (Switzerland)], E-mail: pablo.saiz@cern.ch

    2008-07-15

    Starting from mid-2008, the ALICE detector at CERN LHC will collect data at a rate of 4PB per year. ALICE will use exclusively distributed Grid resources to store, process and analyse this data. The top-level management of the Grid resources is done through the AliEn (ALICE Environment) system, which is in continuous development since year 2000. AliEn presents several original solutions, which have shown their viability in a number of large exercises of increasing complexity called Data Challenges. This paper describes the AliEn architecture: Job Management, Data Management and UI. The current status of AliEn will be illustrated, as well as the performance of the system during the data challenges. The paper also describes the future AliEn development roadmap.

  14. AliEn: ALICE Environment on the GRID

    CERN Multimedia

    Bagnasco, S; Buncic, P; Carminati, F; Cirstoiu, C; Grigoras, C; Hayrapetyan, A; Harutyunyan, A; Peters, A J; Saiz, P

    2007-01-01

    Starting from mid-2008, the ALICE detector at CERN LHC will collect data at a rate of 4PB per year. ALICE will use exclusively distributed Grid resources to store, process and analyse this data. The top-level management of the Grid resources is done through the AliEn (ALICE Environment) system, which is in continuous development since year 2000. AliEn presents several original solutions, which have shown their viability in a number of large exercises of increasing complexity called Data Challenges. This paper describes the AliEn architecture: Job Management, Data Management and UI. The current status of AliEn will be illustrated, as well as the performance of the system during the data challenges. The paper also describes the future AliEn development roadmap.

  15. AliEn: ALICE Environment on the GRID

    CERN Document Server

    CERN. Geneva

    2012-01-01

    AliEn is the GRID middleware used by the ALICE collaboration. It provides all the components that are needed to manage the distributed resources. AliEn is used for all the computing workflows of the experiment: Montecarlo production, data replication and reconstruction and organixed or chaotic user analysis. Moreover, AliEn is also being used by other experiments like PANDA and CBM. The main components of AliEn are a centralized file and metadata catalogue, a job execution model and file replication model. These three components have been evolving over the last 10 years to make sure that the satisfy the computing requirements of the experiment, which keep increasing every year.

  16. Evaluation test of ALIS in Cambodia for humanitarian demining

    Science.gov (United States)

    Sato, Motoyuki

    2010-04-01

    ALIS is a hand-held dual sensor developed by Tohoku University, Japan since 2002. Dual sensor is a general name of sensor for humanitarian demining, which are equipped with metal detector and GPR. ALIS is only one hand-held dual sensor, which can record the sensor position with sensor signals. Therefore, the data can be processed after data acquisition, and can increase the imaging capability. ALIS has been tested in some mine affected courtiers including Afghanistan (2004), Egypt(2005), Croatia(2006-) and Cambodia(2007-). Mine fields at each country has different conditions and soil types. Therefore testes at the real mine fields are very important. ALIS has detected more than 30 AP-Mines in evaluation test in Cambodia held in 2009.

  17. AliEn - ALICE environment on the GRID

    CERN Document Server

    Saiz, P; Buncic, P; Piskac, R; Revsbech, J E; Sego, V

    2003-01-01

    AliEn (http://alien.cern.ch) (ALICE Environment) is a Grid framework built on top of the latest Internet standards for information exchange and authentication (SOAP, PKI) and common Open Source components. AliEn provides a virtual file catalogue that allows transparent access to distributed datasets and a number of collaborating Web services which implement the authentication, job execution, file transport, performance monitor and event logging. In the paper we will present the architecture and components of the system.

  18. AliEn - ALICE environment on the GRID

    Energy Technology Data Exchange (ETDEWEB)

    Saiz, P. E-mail: pablo.saiz@cern.ch; Aphecetche, L.; Buncic, P.; Piskac, R.; Revsbech, J.-E.; Sego, V

    2003-04-21

    AliEn (http://alien.cern.ch) (ALICE Environment) is a Grid framework built on top of the latest Internet standards for information exchange and authentication (SOAP, PKI) and common Open Source components. AliEn provides a virtual file catalogue that allows transparent access to distributed datasets and a number of collaborating Web services which implement the authentication, job execution, file transport, performance monitor and event logging. In the paper we will present the architecture and components of the system.

  19. Site Protection Program and Progress Report of Ali Observatory, Tibet

    Science.gov (United States)

    Yao, Yongqiang; Zhou, Yunhe; Wang, Xiaohua; He, Jun; Zhou, Shu

    2015-08-01

    The Ali observatory, Tibet, is a promising new site identified through ten year site survey over west China, and it is of significance to establish rules of site protection during site development. The site protection program is described with five aspects: site monitoring, technical support, local government support, specific organization, and public education. The long-term sky brightness monitoring is ready with site testing instruments and basic for light pollution measurement; the monitoring also includes directions of main light sources, providing periodical reports and suggestions for coordinating meetings. The technical supports with institutes and manufacturers help to publish lighting standards and replace light fixtures; the research pays special attention to the blue-rich sources, which impact the important application of high altitude sites. An official leading group towards development and protection of astronomical resources has been established by Ali government; one of its tasks is to issue regulations against light pollution, including special restrictions of airport, mine, and winter heating, and to supervise lighting inspection and rectification. A site protection office under the official group and local astronomical society are organized by Ali observatory; the office can coordinate in government levels and promote related activities. A specific website operated by the protection office releases activity propaganda, evaluation results, and technical comparison with other observatories. Both the site protection office and Ali observatory take responsibility for public education, including popular science lectures, light pollution and energy conservation education. Ali Night Sky Park has been constructed and opens in 2014, and provides a popular place and observational experience. The establishment of Ali Observatory and Night Sky Park brings unexpected social influence, and the starry sky trip to Ali becomes a new format of culture

  20. Šalių atsakomybė statybos rangos santykiuose

    OpenAIRE

    Jekentaitė, Ugnė

    2011-01-01

    Magistro baigiamojo darbo tema – „Šalių atsakomybė statybos rangos santykiuose“. Raktiniai žodžiai: statyba, teisiniai statybos santykiai, statybos rangos santykiai, statybos rangos sutartis, subrangos sutartis, užsakovas, rangovas, subrangovas, atsakomybė. Sklandus ir efektyvus statybos proceso įgyvendinimas didžiąja dalimi priklauso nuo to, kaip aiškiai ir suprantamai statybos rangos sutartis ir teisės norminiai aktai apibrėžia sutarties šalių teises ir pareigas, paskirsto jų riz...

  1. Izraba alternativnih energij: etično ali ne?

    OpenAIRE

    Brodnjak, Tadeja

    2014-01-01

    Diplomska naloga predstavlja različne načine izrabe alternativnih virov nekoč in danes. Drugo poglavje opredeljuje alternativne vire in njihove možnosti uporabe na praktičnih primerih. Sledimo v opredeljevanje celotne skupine alternativnih obnovljivih virov, kot so sončna energija, vodna energija, raba biomase in geotermalne energije. V tretjem poglavju se lotimo vprašanja, ali je ravnanje ljudi z energetskimi viri etično ali ne, saj se moramo zavedati, da smo ljudje največji sovražniki na...

  2. The AliEn system, status and perspectives

    CERN Document Server

    Buncic, P; Peters, A J

    2003-01-01

    AliEn is a production environment that implements several components of the Grid paradigm needed to simulate, reconstruct and analyse HEP data in a distributed way. The system is built around Open Source components, uses the Web Services model and standard network protocols to implement the computing platform that is currently being used to produce and analyse Monte Carlo data at over 30 sites on four continents. The aim of this paper is to present the current AliEn architecture and outline its future developments in the light of emerging standards.

  3. The AliEn system, status and perspectives

    OpenAIRE

    P. Buncic; Saiz, P.; Peters, A.J.

    2003-01-01

    AliEn is a production environment that implements several components of the Grid paradigm needed to simulate, reconstruct and analyse HEP data in a distributed way. The system is built around Open Source components, uses the Web Services model and standard network protocols to implement the computing platform that is currently being used to produce and analyse Monte Carlo data at over 30 sites on four continents. The aim of this paper is to present the current AliEn architecture and outline i...

  4. The final story on the ALA3/ALIS1 complex

    DEFF Research Database (Denmark)

    Lopez Marques, Rosa Laura

    .         Together with ALIS1, we have found that ALA3, localises to the Golgi apparatus in plant cells. Expression of a ß-glucuronidase (GUS) gene under the control of the promoter for either ALIS1 or ALA3 showed a high expression level for both promoters at the columella root cap. Two independent lines of ala3...... of the growth medium. Electron micrographs show cellular defects in cells of the root cap of mutant plants related to the formation of vesicles in the trans side of the Golgi apparatus. We propose that the flippase activity of the ALA3/ALIS1 complex in the Golgi is required for important secretory processes...... in endogenous P4-ATPases. Our results indicated that ALIS1 functions as a true ß-subunit for the Arabidopsis putative flippase ALA3, being required for ATP-dependent phospholipid transport and for genetic complementation of the yeast P4-ATPase gene Drs2, which is involved in vesicle budding from the late Golgi...

  5. Enhancing the AliEn Web Service Authentication

    Science.gov (United States)

    Zhu, Jianlin; Saiz, Pablo; Carminati, Federico; Betev, Latchezar; Zhou, Daicui; Mendez Lorenzo, Patricia; Grigoras, Alina Gabriela; Grigoras, Costin; Furano, Fabrizio; Schreiner, Steffen; Vladimirovna Datskova, Olga; Sankar Banerjee, Subho; Zhang, Guoping

    2011-12-01

    Web Services are an XML based technology that allow applications to communicate with each other across disparate systems. Web Services are becoming the de facto standard that enable inter operability between heterogeneous processes and systems. AliEn2 is a grid environment based on web services. The AliEn2 services can be divided in three categories: Central services, deployed once per organization; Site services, deployed on each of the participating centers; Job Agents running on the worker nodes automatically. A security model to protect these services is essential for the whole system. Current implementations of web server, such as Apache, are not suitable to be used within the grid environment. Apache with the mod_ssl and OpenSSL only supports the X.509 certificates. But in the grid environment, the common credential is the proxy certificate for the purpose of providing restricted proxy and delegation. An Authentication framework was taken for AliEn2 web services to add the ability to accept X.509 certificates and proxy certificates from client-side to Apache Web Server. The authentication framework could also allow the generation of access control policies to limit access to the AliEn2 web services.

  6. Exhaled breath analysis discriminates phenotypes of acute lung injury (ALI)

    NARCIS (Netherlands)

    Bos, L.D.J.; Hemmes, S.N.T.; Nijsen, T.M.E.; Sterk, P.J; Schultz, M.J.

    2012-01-01

    Introduction It has been postulated that the pathophysiology and clinical presentation of ALI based on pulmonary and non-pulmonary etiology represent different phenotypes1. Until now, little biological evidence on the molecular level has been presented to support this hypothesis. Exhaled air conta

  7. Improved performance of QCD code on ALiCE

    CERN Document Server

    Sroczynski, Z

    2003-01-01

    We present results for the performance of QCD code on ALiCE, the Alpha-Linux Cluster Engine at Wuppertal. We describe the techniques employed to optimise the code, including the metaprogramming of assembler kernels, the effects of data layout and an investigation into the overheads incurred by the communication.

  8. Improved performance of QCD code on ALiCE

    Science.gov (United States)

    Sroczynski, Z.

    2003-05-01

    We present results for the performance of QCD code on ALiCE , the Alpha-Linux Cluster Engine at Wuppertal. We describe the techniques employed to optimise the code, including the metaprogramming of assembler kernels, the effects of data layout and an investigation into the overheads incurred by the communication.

  9. Suurajatolla Ali al-Sistani saabus Najaffi / Kalev Vilgats

    Index Scriptorium Estoniae

    Vilgats, Kalev

    2004-01-01

    Mässulise shiiidivaimuliku Moqtada al-Sadri Mahdi armee võitlejad on pidanud Najafis USA vägedega lahinguid juba kolm nädalat. Iraagi kõrgeim shiiiavaimulik suurajatolla Ali al-Sistani kutsub kõiki iraaklasi endaga Najaffi marssima, et lahingutele lõpp teha

  10. ALIS through the Looking Glass: Changing Perceptions of Performance Indicators.

    Science.gov (United States)

    Williamson, John; And Others

    1992-01-01

    Follows up on a Williamson and Fitz-Gibbon article (1990) focusing on the impact of a performance indicator project, COMBSE (Confidential Measurement Based Self-Evaluation), on secondary school English departments. This article describes COMBSE's metamorphosis into another system, ALIS (A Level Information System), that has transcended the…

  11. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    ... used for selecting the appropriate ALI or DAC value. The ALIs and DACs for inhalation are given for an...,” “Inhalation ALI,” and “DAC,” are applicable to occupational exposure to radioactive material. The ALIs in this.../50) instead of being DAC) values are derived limits intended...

  12. Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy.

    Science.gov (United States)

    Stubbs, Sarah H; Conrad, Nicholas K

    2015-01-01

    Pre-mRNA processing is mechanistically linked to transcription with RNA pol II serving as a platform to recruit RNA processing factors to nascent transcripts. The TREX complex member, REF/Aly, has been suggested to play roles in transcription and nuclear RNA stability in addition to its more broadly characterized role in mRNA export. We employed RNA-seq to identify a subset of transcripts with decreased expression in both nuclear and cytoplasmic fractions upon REF/Aly knockdown, which implies that REF/Aly affects their expression upstream of its role in mRNA export. Transcription inhibition experiments and metabolic labeling assays argue that REF/Aly does not affect stability of selected candidate transcripts. Instead, ChIP assays and nuclear run-on analysis reveal that REF/Aly depletion diminishes the transcription of these candidate genes. Furthermore, we determined that REF/Aly binds directly to candidate transcripts, supporting a direct effect of REF/Aly on candidate gene transcription. Taken together, our data suggest that the importance of REF/Aly is not limited to RNA export, but that REF/Aly is also critical for gene expression at the level of transcription. Our data are consistent with the model that REF/Aly is involved in linking splicing with transcription efficiency.

  13. Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS

    Science.gov (United States)

    Pereira, Marcelo L. M.; Ortolan, Luana S.; Sercundes, Michelle K.; Debone, Daniela; Murillo, Oscar; Lima, Flávia A.

    2016-01-01

    Malaria is a serious disease, caused by the parasite of the genus Plasmodium, which was responsible for 440,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications in severe malaria. The murine model DBA/2 reproduces the clinical signs of ALI/ARDS in humans, when infected with Plasmodium berghei ANKA. High levels of HO-1 were reported in cases of severe malaria. Our data indicated that the HO-1 mRNA and protein expression are increased in mice that develop malaria-associated ALI/ARDS (MA-ALI/ARDS). Additionally, the hemin, a HO-1 inducing drug, prevented mice from developing MA-ALI/ARDS when administered prior to the development of MA-ALI/ARDS in this model. Also, hemin treatment showed an amelioration of respiratory parameters in mice, high VEGF levels in the sera, and a decrease in vascular permeability in the lung, which are signs of ALI/ARDS. Therefore, the induction of HO-1 before the development of MA-ALI/ARDS could be protective. However, the increased expression of HO-1 on the onset of MA-ALI/ARDS development may represent an effort to revert the phenotype of this syndrome by the host. We therefore confirm that HO-1 inducing drugs could be used for prevention of MA-ALI/ARDS in humans. PMID:27974865

  14. Predictive criteria to study the pathogenesis of malaria-associated ALI/ARDS in mice.

    Science.gov (United States)

    Ortolan, Luana S; Sercundes, Michelle K; Barboza, Renato; Debone, Daniela; Murillo, Oscar; Hagen, Stefano C F; Russo, Momtchilo; D' Império Lima, Maria Regina; Alvarez, José M; Amaku, Marcos; Marinho, Claudio R F; Epiphanio, Sabrina

    2014-01-01

    Malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS) often results in morbidity and mortality. Murine models to study malaria-associated ALI/ARDS have been described; we still lack a method of distinguishing which mice will develop ALI/ARDS before death. This work aimed to characterize malaria-associated ALI/ARDS in a murine model and to demonstrate the first method to predict whether mice are suffering from ALI/ARDS before death. DBA/2 mice infected with Plasmodium berghei ANKA developing ALI/ARDS or hyperparasitemia (HP) were compared using histopathology, PaO2 measurement, pulmonary X-ray, breathing capacity, lung permeability, and serum vascular endothelial growth factor (VEGF) levels according to either the day of death or the suggested predictive criteria. We proposed a model to predict malaria-associated ALI/ARDS using breathing patterns (enhanced pause and frequency respiration) and parasitemia as predictive criteria from mice whose cause of death was known to retrospectively diagnose the sacrificed mice as likely to die of ALI/ARDS as early as 7 days after infection. Using this method, we showed increased VEGF levels and increased lung permeability in mice predicted to die of ALI/ARDS. This proposed method for accurately identifying mice suffering from ALI/ARDS before death will enable the use of this model to study the pathogenesis of this disease.

  15. Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice

    Directory of Open Access Journals (Sweden)

    Luana S. Ortolan

    2014-01-01

    Full Text Available Malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS often results in morbidity and mortality. Murine models to study malaria-associated ALI/ARDS have been described; we still lack a method of distinguishing which mice will develop ALI/ARDS before death. This work aimed to characterize malaria-associated ALI/ARDS in a murine model and to demonstrate the first method to predict whether mice are suffering from ALI/ARDS before death. DBA/2 mice infected with Plasmodium berghei ANKA developing ALI/ARDS or hyperparasitemia (HP were compared using histopathology, PaO2 measurement, pulmonary X-ray, breathing capacity, lung permeability, and serum vascular endothelial growth factor (VEGF levels according to either the day of death or the suggested predictive criteria. We proposed a model to predict malaria-associated ALI/ARDS using breathing patterns (enhanced pause and frequency respiration and parasitemia as predictive criteria from mice whose cause of death was known to retrospectively diagnose the sacrificed mice as likely to die of ALI/ARDS as early as 7 days after infection. Using this method, we showed increased VEGF levels and increased lung permeability in mice predicted to die of ALI/ARDS. This proposed method for accurately identifying mice suffering from ALI/ARDS before death will enable the use of this model to study the pathogenesis of this disease.

  16. Optical Turbulence Characterization by WRF model above Ali, Tibet

    Science.gov (United States)

    Wang, Hongshuai; Yao, Yongqiang; Liu, Liyong; Qian, Xuan; Yin, Jia

    2015-04-01

    Atmospheric optical turbulence modeling and forecast for astronomy is a relatively recent discipline, but has played important roles in site survey, optimization of large telescope observing tables, and in the applications of adaptive optics technique. The numerical approach, by using of meteorological parameters and parameterization of optical turbulence, can provide all the optical turbulence parameters related, such as C2n profile, coherent length, wavefront coherent time, seeing, isoplanatic angle, and so on. This is particularly interesting for searching new sites without the long and expensive site testing campaigns with instruments. Earlier site survey results by the site survey team of National Astronomical Observatories of China imply that the south-west Tibet, Ali, is one of the world best IR and sub-mm site. For searching the best site in Ali area, numerical approach by Weather and Research Forecasting (WRF) model had been used to evaluate the climatology of the optical turbulence. The WRF model is configured over a domain 200km×200km with 1km horizontal resolution and 65 vertical levels from ground to the model top(10millibars) in 2010. The initial and boundary conditions for the model are provided by the 1° × 1° Global Final Analysis data from NCEP. The distribution and seasonal variation of optical turbulence parameters over this area are presented.

  17. Peran Mukti Ali dalam Pengembangan Toleransi Antar Agama di Indonesia

    Directory of Open Access Journals (Sweden)

    Khairah Husin

    2014-06-01

    Full Text Available Agama sebagai sasaran kajian penelitian sudah banyak dilakukan oleh para sarjana disiplin ilmu. Mereka melakukan penelitian terhadap berbagai aspek dari agama, baik aspek ide maupun aspek perwujudan dalam kenyataan. Dimulai dari keyakinan dan ajaran yang dimiliki oleh suatu agama hingga pengaruh agama pada kehidupan masyarakat pemeluk agama tersebut. Kalau yang dimaksud metode dalam ilmu perbandingan agama adalah cara untuk memperoleh dan mamahami kebenaran agama dari realitas empiris, atau lebih tepatnya “kebenaran ilmiah agamis”, maka pendekatan tiada lain adalah suatu sikap ilmiah (persepsi dari seorang yang harus ditunjukkan untuk menemukan kebenaran ilmiah yang hendak diperoleh. Dengan demikian pendekatan sifatnya umum. Dalan suatu pendekatan tertentu dapat digunakan bermacammacam metode, umpamanya seorang Sosiolog akan mengkaji agama pasti akan menerapkan pendekatan metode-metode sosiologis. Begitu pula Sejarawan, Antropolog, Fenomenolog, dan lain-lain akan menerapkan pendekatan dan metode sesuai dengan latar belakang keahliannya. Maka sasaran ideal dari beberapa pendekatan adalah memperoleh interelasi yang sistematis dari fakta-fakta agama, dan bertujuan untuk mencari jawaban tentang fakta-fakta tersebut dengan menggunakan kesangsian sistematis. Pendekatan keilmuan dalam meneliti agama mencoba mendeskripsikan dunia pemeluk agama secara apa adanya (das sein, bukan didasarkan semestinya secara normatif (das sollen. Dengan demikian, pendekatan keilmuan yang empiris ini menggunakan dan mengadaptasi pendekatanpendekatan ilmu-ilmu sosial dan budaya. Dari sekian tokoh ilmu Perbandingan Agama, kebanyakan dari mereka merupakan ilmuwan Barat. Namun demikian ada juga beberapa tokoh perbandingan agama dari duni Islam, antara lain adalah Prof. Dr. H.A. Mukti Ali, Ibnu Hazm dan As-Syahrastani. Sementara Ibnu Hazm Al Andalusy dan As-Syahrastani merupakan tokoh-tokoh Perbaga Muslim dari zaman klasik – zaman ketika Perbaga belum terbentuk sebagai

  18. Studying the potential role of ALIS proteins on the functionality of ALA2

    DEFF Research Database (Denmark)

    Lopez Marques, Rosa Laura; Poulsen, Lisbeth Rosager; Meffert, Katharina

    by lack of DRS2 in yeast. Tissue specific expression patterns of ALA2 and ALIS genes indicate that different ALIS isoforms may interact with ALA2 in diverse parts of the plant. At present we are studying the subcellular localization of ALA2 in planta in order to understand better its possible...

  19. Viral factors reveal a role for REF/Aly in nuclear RNA stability.

    Science.gov (United States)

    Stubbs, Sarah H; Hunter, Olga V; Hoover, Ashley; Conrad, Nicholas K

    2012-04-01

    TREX is a conserved multiprotein complex that is necessary for efficient mRNA export to the cytoplasm. In Saccharomyces cerevisiae, the TREX complex is additionally implicated in RNA quality control pathways, but it is unclear whether this function is conserved in mammalian cells. The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein binds and recruits the TREX component REF/Aly to viral mRNAs. Here, we demonstrate that REF/Aly is recruited to the KSHV noncoding polyadenylated nuclear (PAN) RNA by ORF57. This recruitment correlates with ORF57-mediated stabilization of PAN RNA, suggesting that REF/Aly promotes nuclear RNA stability. Further supporting this idea, tethering REF/Aly to PAN RNA is sufficient to increase the nuclear abundance and half-life of PAN RNA but is not sufficient to promote its export. Interestingly, REF/Aly appears to protect the poly(A) tail from deadenylation, and REF/Aly-stabilized transcripts are further adenylated over time, consistent with previous reports linking poly(A) tail length with nuclear RNA surveillance. These studies show that REF/Aly can stabilize nuclear RNAs independently of their export and support a broader conservation of RNA quality control mechanisms from yeast to humans.

  20. Dynamic virtual AliEn Grid sites on Nimbus with CernVM

    Science.gov (United States)

    Harutyunyan, A.; Buncic, P.; Freeman, T.; Keahey, K.

    2010-04-01

    We describe the work on enabling one click deployment of Grid sites of AliEn Grid framework on the Nimbus 'science cloud' at the University of Chicago. The integration of computing resources of the cloud with the resource pool of AliEn Grid is achieved by leveraging two mechanisms: the Nimbus Context Broker developed at Argonne National Laboratory and the University of Chicago, and CernVM - a baseline virtual software appliance for LHC experiments developed at CERN. Two approaches of dynamic virtual AliEn Grid site deployment are presented.

  1. Dynamic virtual AliEn Grid sites on Nimbus with CernVM

    Energy Technology Data Exchange (ETDEWEB)

    Harutyunyan, A [Armenian e-Science Foundation, Yerevan (Armenia); Buncic, P [CERN, Geneva (Switzerland); Freeman, T; Keahey, K, E-mail: hartem@mail.yerphi.a, E-mail: Predrag.Buncic@cern.c, E-mail: tfreeman@mcs.anl.go, E-mail: keahey@mcs.anl.go [University of Chicago, Chicago IL (United States)

    2010-04-01

    We describe the work on enabling one click deployment of Grid sites of AliEn Grid framework on the Nimbus 'science cloud' at the University of Chicago. The integration of computing resources of the cloud with the resource pool of AliEn Grid is achieved by leveraging two mechanisms: the Nimbus Context Broker developed at Argonne National Laboratory and the University of Chicago, and CernVM - a baseline virtual software appliance for LHC experiments developed at CERN. Two approaches of dynamic virtual AliEn Grid site deployment are presented.

  2. Gaia16ali and Gaia16alj supernovae confirmed by Euler imaging

    Science.gov (United States)

    Roelens, M.; Blanco-Cuaresma, S.; Semaan, T.; Palaversa, L.; Mowlavi, N.; Eyer, L.

    2016-04-01

    We report confirmation of Gaia Science Alerts transients Gaia16ali and Gaia16alj. Images were obtained through modified Gunn R band filter of the ECAM instrument installed on the Swiss 1.2m Euler telescope at La Silla, on 2016 April 19 - 22 UT. These new sources are supernovae candidates and they are not visible in archival 2MASS and DSS images: Gaia16ali (near centre of galaxy GALEXASC J041551.89-621715.5) and Gaia16alj.

  3. Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

    DEFF Research Database (Denmark)

    Afshari, Arash; Brok, Jesper; Møller, Ann

    2010-01-01

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are critical conditions that are associated with high mortality and morbidity. Aerosolized prostacyclin has been used to improve oxygenation despite the limited evidence available so far.......Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are critical conditions that are associated with high mortality and morbidity. Aerosolized prostacyclin has been used to improve oxygenation despite the limited evidence available so far....

  4. Preliminary studies on the extraction of Glycospanonins in Tongkat Ali extract

    Science.gov (United States)

    Abirame, S.; Sivakumar, K.; Chua, L. S.; Sarmidi, M. R.

    2016-06-01

    Eurycoma longifolia, locally known as Tongkat Ali, is a famous medicinal plant in the family of Simaroubaceae and well known for its aphrodisiac properties from its water extract. The root of E. longifolia is used to extract wide range bioactive components of Tongkat Ali. Previous works standardised Tongkat Ali extracts by measuring the concentration of eurycomanone, a quassinoid marker chemical, within the overall extract. There is a newer Malaysian standard that specifies that Tongkat Ali can be standardised to glycosaponin, thus it is desired to determine how extraction parameters such as particle size, extraction temperature, and solvent type affects the glycosaponin content in the extract. The overall study is aimed to determine how the extraction parameters affect the glycosaponin amount in extract. This paper presents the preliminary work where in this study the effect of particle size on overall extract and glycosaponin quantification method development is presented. A reflux extraction method was used to extract Tongkat Ali with a particle size of 0.5 mm, 1.0 mm and 2.0 mm of raw material to study effect of particle size on overall extract. Water and methanol were the two types of solvent used for extraction to study the quantity of glycosaponin.

  5. Ground-based multi-station spectroscopic imaging with ALIS. - Scientific highlights, project status and future prospects

    Science.gov (United States)

    Brändström; Gustavsson, Björn; Pellinen-Wannberg, Asta; Sandahl, Ingrid; Sergienko, Tima; Steen, Ake

    2005-08-01

    The Auroral Large Imaging System (ALIS) was first proposed at the ESA-PAC meeting in Lahnstein 1989. The first spectroscopic imaging station was operational in 1994, and since then up to six stations have been in simultaneous operation. Each station has a scientific-grade CCD-detector and a filter-wheel for narrow-band interference-filters with six positions. The field-of-view is around 70°. Each imager is mounted in a positioning system, enabling imaging of a common volume from several sites. This enables triangulation and tomography. Raw data from ALIS is freely available at ("http://alis.irf.se") and ALIS is open for scientific colaboration. ALIS made the first unambiguous observations of Radio-induced optical emissions at high latitudes, and the detection of water in a Leonid meteor-trail. Both rockets and satellite coordination are considered for future observations with ALIS.

  6. Highly pathogenic avian influenza virus nucleoprotein interacts with TREX complex adaptor protein Aly/REF.

    Science.gov (United States)

    Balasubramaniam, Vinod R M T; Hong Wai, Tham; Ario Tejo, Bimo; Omar, Abdul Rahman; Syed Hassan, Sharifah

    2013-01-01

    We constructed a novel chicken (Gallus gallus) lung cDNA library fused inside yeast acting domain vector (pGADT7). Using yeast two-hybrid screening with highly pathogenic avian influenza (HPAI) nucleoprotein (NP) from the strain (A/chicken/Malaysia/5858/2004(H5N1)) as bait, and the Gallus gallus lung cDNA library as prey, a novel interaction between the Gallus gallus cellular RNA export adaptor protein Aly/REF and the viral NP was identified. This interaction was confirmed and validated with mammalian two hybrid studies and co-immunoprecipitation assay. Cellular localization studies using confocal microscopy showed that NP and Aly/REF co-localize primarily in the nucleus. Further investigations by mammalian two hybrid studies into the binding of NP of other subtypes of influenza virus such as the swine A/New Jersey/1976/H1N1 and pandemic A/Malaysia/854/2009(H1N1) to human Aly/REF, also showed that the NP of these viruses interacts with human Aly/REF. Our findings are also supported by docking studies which showed tight and favorable binding between H5N1 NP and human Aly/REF, using crystal structures from Protein Data Bank. siRNA knockdown of Aly/REF had little effect on the export of HPAI NP and other viral RNA as it showed no significant reduction in virus titer. However, UAP56, another component of the TREX complex, which recruits Aly/REF to mRNA was found to interact even better with H5N1 NP through molecular docking studies. Both these proteins also co-localizes in the nucleus at early infection similar to Aly/REF. Intriguingly, knockdown of UAP56 in A549 infected cells shows significant reduction in viral titer (close to 10 fold reduction). Conclusively, our study have opened new avenues for research of other cellular RNA export adaptors crucial in aiding viral RNA export such as the SRSF3, 9G8 and ASF/SF2 that may play role in influenza virus RNA nucleocytoplasmic transport.

  7. Probing the origin of our universe through primordial gravitational waves by Ali CMB project

    CERN Document Server

    Cai, Yi-Fu

    2016-01-01

    This is a research highlight invited by SCIENCE CHINA Physics, Mechanics & Astronomy. In this article we report the Ali project of the cosmic microwave background (CMB) observation, which is under design in Tibet of China. The scientific goal of this project will help us to probe the origin of our universe by detecting the primordial B-mode of CMB polarization to falsify various theoretical models of the very early universe in the future. We also estimate the forecast for the observational ability of the Ali project.

  8. A forgotten Ottoman composer: Ali Şîrûganî Dede

    Directory of Open Access Journals (Sweden)

    M. Emin Soydaş

    2007-10-01

    Full Text Available Although being one of the major composers of religious music in the Ottoman era, Ali Şîrûganî Dede, who was famous throughout his life as well as afterwards, is not known nowadays much well as he deserves. In this article Ali Şîrûganî Dede is introduced and information is given on his musicianship and his works, while his situation in the history of Ottoman music is pointed out and especially his importance with regard to religious music is emphasized. Some new information about the subject is also presented within this work.

  9. 家蚕Aly/REF的基因克隆、序列分析及其细胞定位%Cloning, sequence analysis and cellular localization of Aly/REF from the silkworm, Bombyx mori

    Institute of Scientific and Technical Information of China (English)

    钟金凤; 曹广力; 薛仁宇; 贡成良

    2011-01-01

    RNA和输出因子结合蛋白(RNA and exportfactor binding proteins,REF/Aly)参与RNA的稳定、加工和输出.本研究参照已公开的家蚕Bombyx mori aly序列(GenBank登录号:DQ497195.1),通过RT-PCR克隆了家蚕aly/ref基因(Bmaly/ref).测序结果显示,该基因的开放读码框为765 bp,编码254个氨基酸残基,BmAly/REF与黑腹果蝇Drosophila melanogaster、小鼠Mus musculus的同源体的氨基酸序列一致性分别为49.7%和52.7%.结构预测结果显示,BmAly/REF具有REF家族的与RNA结合的结构域RRM,N和C端分别具有REF-N和REF-C基序.进化分析结果显示,昆虫的ALY/REF聚为一类,BmAly/REF与赤拟谷盗tribolium castaneum、意大利蜜蜂Apis mellifera的Aly/REF较为接近.将Bmaly/ref基因克隆进pGS21a(+)载体进行原核表达,重组蛋白免疫小鼠,获得鼠抗BmAly/REF多抗.免疫荧光实验结果显示,BmAly/REF在细胞质和细胞核中均有分布,但主要分布在细胞核中.芯片数据分析显示Bmaly/ref基因在家蚕幼虫5龄第3天各组织中均有较高水平的表达.研究结果显示BmAly/REF可能在RNA的核输出方面发挥作用,为进一步探讨BmAly/REF的功能奠定了基础.%RNA and export factor binding proteins (Aly/REF) play important roles in RNA stability, processing and nuclear export. Referring to the sequence of Bombyx mori aly gene ( GenBank accession no. DQ497195.1 ), the aly/refgene (Bmaly/ref) from the silkworm, B. mori, was cloned via RT-PCR. The sequencing result showed that the open reading frame (ORF) of Bmaly/ref is 765 bp in length, encoding 254 amino acid residues, and the amino acid sequence of BmAIy/REF showed 49.7% and 52.7% identities with the homologs of Drosophila melanogaster and Mus musculus, respectively. The structure prediction displayed that BmAIy/REF contains RNA binding domain (RRM), REF-N and REF-C motif of REF subfamily. Phylogenetic analysis showed that the insect Aly/REF proteins clustered to a group and the BmAly/REF was close

  10. 肺损伤预测评分在ALI/ARDS早期诊断中的应用%Evaluation of Lung Injury Prediction Score in Early Identification of Patients at Risk of ALI/ARDS

    Institute of Scientific and Technical Information of China (English)

    夏炎火; 童秋玲; 林锡芳; 王丹; 朱海萍; 戴震宇

    2013-01-01

    目的 评估肺损伤预测评分(LIPS)在早期预测急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)中的价值和可行性.方法 对43例ALI/ARDS患者和32例非ALI/ARDS患者分别进行LIPS、肺损伤评分(LIS)和急性生理学及慢性健康状况(APACHE)Ⅱ评分,计算两组病死率,并对结果进行比较和相关性分析,利用受试者工作特征(ROC)曲线评价LIPS和LIS的诊断分辨度.结果 与非ALI/ARDS组相比,ALI/ARDS组的ICU平均住院时间、LIPS和LIS较高,而PaO2/FiO2相对较低,且病死率高达34.88%.LIPS与LIS呈明显正相关(r=0.669,P<0.001),但LIPS、LIS与APACHEⅡ评分间的相关性不强(r分别为0.460和0.342,P<0.05).LIPS评分对预测ALI/ARDS有意义[曲线下面积(AUC) =0.832,95% CI:0.728 ~0.908,P<0.001],当LIPS>7分时,预测ALI/ARDS的敏感度为83.72%,特异性为78.12%.LIS评分对预测ALI/ ARDS也有意义(AUC=0.802,95% CI:0.693 ~0.885,P<0.001),LIS>0.67分时,预测ALI/ARDS的敏感度、特异性分别为81.40%和77.80%.结论 LIPS对预测ALI/ARDS的准确性较好,且与LIS系统具有较好的相关性,早期即可获得,临床操作性较强,该评分系统为早期预测ALI/ARDS提供了可能.%Objective To evaluate the value and feasibility of lung injury prediction score ( LIPS) in early identification of ALI/ ARDS. Methods The clinical data of 43 ALI/ARDS patients and 32 non - ALI / ARDS patients was collected and evaluated with LIPS, lung injury score(LIS) and APACHE II score system. Mortality of two groups and correlation analysis were evaluated. The forecast value of LIPS and LIS in diagnosis of ALI/ARDS was analyzed by receiver operator characteristic( ROC) curve. Results Compared with non -ALI /ARDS group, the average hospitalization days in ICU, LIPS and LIS of ALI / ARDS group were significantly higher,but the PaO2/ FiO2 was lower. Furthermore, the mortality of ALI/ARDS group was very high (34. 88% ). The LIPS of patients had positive

  11. 76 FR 11756 - Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges

    Science.gov (United States)

    2011-03-03

    ... Bureau of Industry and Security Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export... 766.25 of the Export Administration Regulations (``EAR'' or ``Regulations'') \\1\\ provides, in... the Office of Export Enforcement, may deny the export privileges of any person who has been...

  12. Deployment of dual-sensor ALIS for humanitarian demining in Cambodia

    Science.gov (United States)

    Sato, M.; Takahashi, K.

    2013-06-01

    We are in the process of developing a high-resolution landmine scanning system "ALIS" which produces horizontal slices of the shallow subsurface for visualization of buried explosives and inert clutter. As many AP mines contain minimum amounts of metal, metal detectors need to be combined with a complimentary subsurface imaging sensor. Ground Penetrating Radar (GPR) is widely accepted for subsurface sensing in the fields of geology, archaeology and utility detection. The demining application requires real-time imaging results with centimetre resolution in a highly portable package. The key requirement for sharp images of the subsurface is the precise tracking of the geophysical sensor(s) during data collection. We should also notice that GPR system is a very wide band radar system, and equivalent to UWB radar, which has recently been developed for short-range high-accuracy radar. We are testing simplified but effective signal processing for imaging mines. We are currently testing a dual sensor ALIS which is a realtime sensor tracking system based on a CCD camera and image processing. In this paper we introduce the GPR systems which we have developed for detection of buried antipersonnel mines and small size explosives. ALIS has been deployed in Cambodia since 2009 and detected more than 70 mines in mine fields, and returned more than 13ha cleaned fields to local farmers. We also report the current status of ALIS in Cambodia.

  13. Põhja-Küprose liider soovib isolatsiooni lõppemist / Mehmet Ali Talat ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Talat, Mehmet Ali

    2004-01-01

    Põhja-Küprose liidri väitel soovib türklaste kogukond diplomaatilise tunnustuse asemel isolatsiooni lõppemist. Intervjuus käsitletavad teemad: Küprose saare tulevik, liitumine Euroopa Liiduga, Türgi liitumine euroliiduga. Lisad: Kahe kogukonna - kreeklaste ja türklaste - vahel lõhestatud Küpros; Mehmet Ali Talat

  14. ASTER, ALI and Hyperion sensors data for lithological mapping and ore minerals exploration.

    Science.gov (United States)

    Beiranvand Pour, Amin; Hashim, Mazlan

    2014-01-01

    This paper provides a review of the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), Advanced Land Imager (ALI), and Hyperion data and applications of the data as a tool for ore minerals exploration, lithological and structural mapping. Spectral information extraction from ASTER, ALI, and Hyperion data has great ability to assist geologists in all disciplines to map the distribution and detect the rock units exposed at the earth's surface. The near coincidence of Earth Observing System (EOS)/Terra and Earth Observing One (EO-1) platforms allows acquiring ASTER, ALI, and Hyperion imagery of the same ground areas, resulting accurate information for geological mapping applications especially in the reconnaissance stages of hydrothermal copper and gold exploration, chromite, magnetite, massive sulfide and uranium ore deposits, mineral components of soils and structural interpretation at both regional and district scales. Shortwave length infrared and thermal infrared bands of ASTER have sufficient spectral resolution to map fundamental absorptions of hydroxyl mineral groups and silica and carbonate minerals for regional mapping purposes. Ferric-iron bearing minerals can be discriminated using six unique wavelength bands of ALI spanning the visible and near infrared. Hyperion visible and near infrared bands (0.4 to 1.0 μm) and shortwave infrared bands (0.9 to 2.5 μm) allowed to produce image maps of iron oxide minerals, hydroxyl-bearing minerals, sulfates and carbonates in association with hydrothermal alteration assemblages, respectively. The techniques and achievements reviewed in the present paper can further introduce the efficacy of ASTER, ALI, and Hyperion data for future mineral and lithological mapping and exploration of the porphyry copper, epithermal gold, chromite, magnetite, massive sulfide and uranium ore deposits especially in arid and semi-arid territory.

  15. Cellular and molecular mechanisms of ACE2/Ang1-7/Mas in ALI/ARDS%ACE2/Ang1-7/Mas在ALI/ARDS中作用机制研究

    Institute of Scientific and Technical Information of China (English)

    孙佳; 朱彪

    2016-01-01

    Renin-angiotensin system(RAS)plays important roles in the pathogenesis of acute lung injury(ALI)/acute respiratory distress syndrome(ARDS).About 60% of ARDS patients are shown to develop pulmonary fibrosis with increased mortality rate.Recent researches have demonstrated potent inhibitory of angiotensin-converting enzyme 2 (ACE2)/angiotensin 1-7 (Ang1-7)/Mas axis on ALI/ARDS.This review summarizes the beneficial action of ACE2/Ang1-7/Mas on ALI/ARDS and research progress on relative signaling pathway.%肾素-血管紧张素系统在 ALI/ARDS的病理过程中有重要作用。大约60% ARDS患者进展成肺纤维化且其病死率明显增加。目前研究显示 ACE/AngⅡ/AT1 R 与 ALI/ARDS 发病机制有关,而ACE2/Ang1-7/Mas起负向调节作用———ACE2和Ang1-7对ALI/ARDS有保护作用。因此,本文就 ACE2/Ang1-7/Mas在 ALI/ARDS中的保护作用和相关信号传导通路等方面最新研究进展作一阐述。

  16. PESANTREN AND MODERNITY IN INDONESIA: MA’HAD ALY OF KUNINGAN

    Directory of Open Access Journals (Sweden)

    Didin Nurul Rosidin

    2012-12-01

    Full Text Available In Indonesia where the majority of the population is Muslims, pesantren that has thrived since the arrival of Islam to the shore of the archipelago is still out of the central field of the national educational system. As such, pesantren was and is forced to continually be aware with ongoing new educational developments in the country as the result of modernisation and globalisation. The foundation of Ma’had Aly is one of the ways taken by the pesantrens to response to the current developments within Muslim communities, to define or even maintain their central roles as well as to preserve their tradition in such a modernised and globalised Indonesia. By exploring the foundation of Ma’had Alys in Kuningan as a case study, this article closely elaborates how the pesantren world engages these processes both in their cirricular settings and practices and provides how it negotiates with the ongoing changes within its surrounding communities.

  17. ALIED: Una teoría de la detección de mentiras

    Directory of Open Access Journals (Sweden)

    Chris N. H. Street

    2016-07-01

    Full Text Available En general, somos torpes a la hora de detectar mentiras y tendemos a creer que los demás dicen la verdad con más frecuencia de la que deberíamos. De hecho, los estudios sobre detección de mentiras suelen describir nuestra tendencia a creer a otras personas como un error de juicio. Aunque parezcamos irremediablemente malos a la hora de detectar mentiras, la teoría del Detector de Mentiras Adaptativo (ALIED afirma que, en realidad, hacemos juicios inteligentes y bien informados. Este artículo explora la teoría ALIED y sus implicaciones para quienes deseen pillar a un mentiroso.

  18. ALIS-FLP: Amplified ligation selected fragment-length polymorphism method for microbial genotyping

    DEFF Research Database (Denmark)

    Brillowska-Dabrowska, A.; Wianecka, M.; Dabrowski, Slawomir;

    2008-01-01

    A DNA fingerprinting method known as ALIS-FLP (amplified ligation selected fragment-length polymorphism) has been developed for selective and specific amplification of restriction fragments from TspRI restriction endonuclease digested genomic DNA. The method is similar to AFLP, but differs in tha...... combining the advantages of the AFLP technique with a simple, rapid and cheap polymerase chain reaction product detection method.......A DNA fingerprinting method known as ALIS-FLP (amplified ligation selected fragment-length polymorphism) has been developed for selective and specific amplification of restriction fragments from TspRI restriction endonuclease digested genomic DNA. The method is similar to AFLP, but differs...... for differentiation of the organisms without previous knowledge of their DNA sequence. The usefulness of the method is confirmed by genotyping of 70 previously characterized clinical E. coli isolates. The grouping obtained was identical to the results of REA-PFGE. Versatility of the method is highlighted, i.e. its...

  19. Interoperating AliEn and ARC for a Distributed Tier1 in the Nordic Countries

    CERN Document Server

    Gros, Philippe; Lindemann, Jonas; Saiz, Pablo; Zarochentsev, Andrey

    2011-01-01

    To reach its large computing needs, the ALICE experiment at CERN has developed its own middleware called AliEn, centralised and relying on pilot jobs. One of its strength is the automatic installation of the required packages. The Nordic countries have offered a distributed Tier-1 centre for the CERN experiments, where the job management should be done with the NorduGrid middleware ARC. We have developed an interoperation module to allow to unify several computing sites using ARC, and make them look like a single site from the point of view of AliEn. A prototype has been completed and tested out of production. This talk will present implementation details of the system and its performance in tests.

  20. Common Directions in Caucasian Chalk Circle and Keşanlı Ali Destanı

    OpenAIRE

    ODACI, Serdar

    2016-01-01

    Epic Theater founded by Bertolt Brecht influenced world literaturein the half of 20th century. Epic theater is against to Aristothalesian Theater.Naturally Brehct's plays were translated to Turkish and were presented. SuchTurkish writers as Haldun Taner and Vasıf Öngeren wrote play according toepic theater concept. In this paper common aspects in Keşanlı Ali Destanıand Caucasian Chalk Circle are examined.

  1. "Common Directions in Caucasian Chalk Circle and Keşanlı Ali Destanı"

    OpenAIRE

    ODACI, Serdar

    2010-01-01

    Epic Theater founded by Bertolt Brecht influenced world literature in the half of 20th century. Epic theater is against to Aristothalesian Theater. Naturally Brehct's plays were translated to Turkish and were presented. Such Turkish writers as Haldun Taner and Vasıf Öngeren wrote play according to epic theater concept. In this paper common aspects in Keşanlı Ali Destanı and Caucasian Chalk Circle are examined.

  2. A Study on the Epic of Keşanlı Ali by Haldun Taner

    OpenAIRE

    GARİPER, Cafer

    2014-01-01

    Haldun Taner is a playwright who introduced new directions, approaches and thematic views to Turkish theather. With his work Keşanlı Ali Destanı, he brought in a new successful example of epic theatre. In this work, he deseribes skillfully the lives of people living in shanty houses and creates new characters. He aslo displays beautifully their ways in daily conversations, behaviour, and their philosophy of life in general.

  3. Petrogenesis of skarn related Cu-porphyry intrusion deposit, Ali-Abad- Darreh Zereshk, Yazd

    OpenAIRE

    Batoul Taghipour; Mohammad Ali Mackizadeh

    2011-01-01

    The study area is a part of Cenozoic magmatic belt of Central Iran, which is located in the West of Yazd porovince. Contact metamorphism and skarn occurred in conglomerate part of Sngestan Formation. The Oligocene intrusion bodies of Ali-Abad-Darreh Zereshk are leucocerate and have the chemical composition of granite to granodiorite with calc-alkaline affinity from volcanic arc geological setting. The main mineral assemblage of skarn in order of imprtance is as follow: Garnet + epidote + quar...

  4. Professor Mansour Ali Haseeb: Highlights from a pioneer of biomedical research, physician and scientist

    OpenAIRE

    2013-01-01

    The article highlights the career of Professor Mansour Ali Haseeb (1910 – 1973; DKSM, Dip Bact, FRCPath, FRCP [Lond]), a pioneer worker in health, medical services, biomedical research and medical education in the Sudan. After his graduation from the Kitchener School of Medicine (renamed, Faculty of Medicine, University of Khartoum [U of K]) in 1934, he devoted his life for the development of laboratory medicine. He became the first Sudanese Director of Stack Medical Research Laboratories (19...

  5. Petrogenesis of skarn related Cu-porphyry intrusion deposit, Ali-Abad- Darreh Zereshk, Yazd

    Directory of Open Access Journals (Sweden)

    Batoul Taghipour

    2011-04-01

    Full Text Available The study area is a part of Cenozoic magmatic belt of Central Iran, which is located in the West of Yazd porovince. Contact metamorphism and skarn occurred in conglomerate part of Sngestan Formation. The Oligocene intrusion bodies of Ali-Abad-Darreh Zereshk are leucocerate and have the chemical composition of granite to granodiorite with calc-alkaline affinity from volcanic arc geological setting. The main mineral assemblage of skarn in order of imprtance is as follow: Garnet + epidote + quartz + calcite + pyrite + iron oxides. Brown garnets are the skarn characteristic mineral. EPMA analysis has shown that the chemical composition with garnet belong to andradite-grossular solid-solution (And 65, Gross 30 with more andradite component. The high permeability and presence of carbonate pebbles in conglomerate are two important factors for fluid flow and genesis of garnets. Distinct oscillatory zoning in garnets is resulted from the change of fO2 in fluids. The evolution of Ali-Abad skarn is took place in the range of 380 to 530 ºC, 0.5 Kbar pressure and high fO2. Also close association of this skarn with Ali-Abad intrusive with Cu-porphyry mineralization shows that this skarn is a Cu-porphyry type skarn.

  6. Securing the AliEn File Catalogue - Enforcing authorization with accountable file operations

    Science.gov (United States)

    Schreiner, Steffen; Bagnasco, Stefano; Sankar Banerjee, Subho; Betev, Latchezar; Carminati, Federico; Vladimirovna Datskova, Olga; Furano, Fabrizio; Grigoras, Alina; Grigoras, Costin; Mendez Lorenzo, Patricia; Peters, Andreas Joachim; Saiz, Pablo; Zhu, Jianlin

    2011-12-01

    The AliEn Grid Services, as operated by the ALICE Collaboration in its global physics analysis grid framework, is based on a central File Catalogue together with a distributed set of storage systems and the possibility to register links to external data resources. This paper describes several identified vulnerabilities in the AliEn File Catalogue access protocol regarding fraud and unauthorized file alteration and presents a more secure and revised design: a new mechanism, called LFN Booking Table, is introduced in order to keep track of access authorization in the transient state of files entering or leaving the File Catalogue. Due to a simplification of the original Access Envelope mechanism for xrootd-protocol-based storage systems, fundamental computational improvements of the mechanism were achieved as well as an up to 50% reduction of the credential's size. By extending the access protocol with signed status messages from the underlying storage system, the File Catalogue receives trusted information about a file's size and checksum and the protocol is no longer dependent on client trust. Altogether, the revised design complies with atomic and consistent transactions and allows for accountable, authentic, and traceable file operations. This paper describes these changes as part and beyond the development of AliEn version 2.19.

  7. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALI/ARDS.

    Science.gov (United States)

    Rajasekaran, Surender; Sanfilippo, Dominic; Shoemaker, Allen; Curtis, Scott; Zuiderveen, Sandra; Ndika, Akunne; Stoiko, Michael; Hassan, Nabil

    2012-01-01

    Introduction. In the first 48 hours of ventilating patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), a multipronged approach including packed red blood cell (PRBC) transfusion is undertaken to maintain oxygen delivery. Hypothesis. We hypothesized children with ALI/ARDS transfused within 48 hours of initiating mechanical ventilation would have worse outcome. The course of 34 transfused patients was retrospectively compared to 45 nontransfused control patients admitted to the PICU at Helen DeVos Children's Hospital between January 1st 2008 and December 31st 2009. Results. Mean hemoglobin (Hb) prior to transfusion was 8.2 g/dl compared to 10.1 g/dl in control. P/F ratio decreased from 135.4 ± 7.5 to 116.5 ± 8.8 in transfused but increased from 148.0 ± 8.0 to 190.4 ± 17.8 (P Fisher exact P < 0.282. Conclusion. This study suggests that early transfusions of patients with ALI/ARDS were associated with increased ventilatory needs.

  8. JAliEn - A new interface between the AliEn jobs and the central services

    Science.gov (United States)

    Grigoras, A. G.; Grigoras, C.; Pedreira, M. M.; Saiz, P.; Schreiner, S.

    2014-06-01

    Since the ALICE experiment began data taking in early 2010, the amount of end user jobs on the AliEn Grid has increased significantly. Presently 1/3 of the 40K CPU cores available to ALICE are occupied by jobs submitted by about 400 distinct users, individually or in organized analysis trains. The overall stability of the AliEn middleware has been excellent throughout the 3 years of running, but the massive amount of end-user analysis and its specific requirements and load has revealed few components which can be improved. One of them is the interface between users and central AliEn services (catalogue, job submission system) which we are currently re-implementing in Java. The interface provides persistent connection with enhanced data and job submission authenticity. In this paper we will describe the architecture of the new interface, the ROOT binding which enables the use of a single interface in addition to the standard UNIX-like access shell and the new security-related features.

  9. JAliEn - A new interface between the AliEn jobs and the central services

    CERN Document Server

    Grigoras, A G; Pedreira, M M; Saiz, P; Schreiner, S

    2014-01-01

    Since the ALICE experiment began data taking in early 2010, the amount of end user jobs on the AliEn Grid has increased signif icantly. Presently 1/3 of the 40K CPU cores available to ALICE are occupied by jobs submitted by about 400 distinct users, individually or in organized analysis trains. The overall stability of the AliEn middleware has been excellent throughout the 3 years of running, but the massive amount of end-user analysis and its specific requirements and load has revealed few components which can be improved. One of them is the interface between users and central AliEn services (catalogue, job submission system) which we are currently re-implementing in Java . The interface provides persistent connection with enhanced data and job submission authenticity. In this paper we will describe the architecture of the new interface, the ROOT binding which enables the use of a single interface in addition to the standard UN IX-like access shell and the new security-related features.

  10. Ali Emirî'nin Osmanlı Tarih ve Edebiyat Mecmuası Ali Emiri's Ottoman History And Literature Periodicals

    Directory of Open Access Journals (Sweden)

    Seher ERDOĞAN ÇELTİK

    2013-03-01

    Full Text Available Periodicals are the documents which constitute resources for ourhistory. A kind of literary atmosphere forms around the magazines;feuilleton novel, story, poetry, critics and similar literary works cometogether with the reader via these magazines. Founder of the PublicLibrary, Ali Emirî published two literary periodicals named OttomanHistory and Literature and History and Literature which are thesuccessor to each other. Totally comprising of 36 issues, the first ispublished as 31 and the latter is published as 5 issues. During theirpublication years, the periodical constituted highly literary atmosphereand this atmosphere undertook an encoring mission in youth’s literaryworks.In this study, these periodicals are introduced and theircontributions to our literary and cultural life are mentioned.First of all Ali Emirî published Ottoman History and Literatureand History and Literature with the aim of being useful for his countryand nation. Later he aimed to illuminate the information/sources ofabout Ottoman history and literature and correct document mistakes.He also wanted to replay to the works that were published as anopposition for him through the magazine and, including Mehmet FuatKöprülü he criticized many other people and institutions.Ali Emiri introduces Divanu Lügati't-Türk to Turkish world. Hewho travelled a lot because of his occupation and thus he continuouslycollected new information and documents. As he enlarged Emirisometimes introduced this information to the readers. Ettik şeref-i hizmet-i ecdâdı ferâmûşÂsârına eslâfımızın rağbet olunmazBir gün bilinir kıymeti mecmûamın ammâPek çok aranır ortada mecmûa bulunmazSüreli yayınlar, edebiyat tarihimize kaynaklık eden dokümanlardandır. Dergiler çevresinde genelde edebî bir muhit oluşur; tefrika roman, hikâye, şiir, tenkit ve benzeri gibi edebî ürünler onlar vasıtasıyla okuyucusuyla buluşur. Millet Kütüphanesinin kurucusu olan Ali Emir

  11. Visâlî Ali Çelebi ve Mevlid’i Visâlî Ali Çelebi And His Mevlid

    Directory of Open Access Journals (Sweden)

    Abdülmecit İSLAMOĞLU

    2013-03-01

    Full Text Available Visali Ali Çelebi is one of the XVIth century poets. On the basis of the poet’s work, limited information of his life can be reached. Of this kind of information is that Visali’s name was Ali and hi lived in the time of Suleiman the Magnificent. Poet’s work entitled “Mevlid-i Fahr-i Kâ’inât Muhammedini’l-Mustafâ” is a work composed in the form of mawlid that dealt with the birth of the Prophet, his childhood until seven years of age and some miracles taking place in this period. The only known manuscript copy of Visali Mevlidi is recorded in Türk Dil Kurumu Kütüphanesi, manuscript A/99 numbered. Though the mawlidmost of which was written in the masnawi form of verse, in order toavoid monotony and catch the attention of readers, the verses in theform of qasida/gazel were interspersed throughout text. In the work,intensely, Fâ‘ilâtün Fâ‘ilâtün Fâ‘ilün aruz prosody was used. In theparts written in verse, the language becomes more difficult. It can besaid that in the parts written in the form of masnawi, a plainer lenguageis used. Nevertheless, Arabic-Persian words and phrases are also seenin the Masnawis. In the Mawlid, there also existed completely Arabic orPersian verses. Considering these features, poet’s style and his power inthe field of poetry, it can be said that the work is not simple and fluent.The fat that Mawlid was suddenly finished in the childhood period ofthe Prophet gives the impression that the works was left half finished.However, when the work is compared with other texts written in theform of mawlid, with 1715 verses, it can be categorized among thevoluminous works. In this article, after giving some information aboutthe form and contents of Visali Ali Çelebi’s Mawlid, the transliteratedtext of the only copy of work we could find so far has been presented. Visâlî Ali Çelebi XVI. yüzyıl şairlerindendir. Şairin bilinen tek eseri olan Mevlid’inden yola çıkılarak adının Ali oldu

  12. ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.

    Science.gov (United States)

    Taniguchi, Ichiro; Ohno, Mutsuhito

    2008-01-01

    Loading of export factors onto mRNAs is a key step in gene expression. In vertebrates, splicing plays a role in this process. Specific protein complexes, exon junction complex and transcription/export complex, are loaded onto mRNAs in a splicing-dependent manner, and adaptor proteins such as Aly/REF in the complexes in turn recruit mRNA exporter TAP-p15 onto the RNA. By contrast, how export factors are recruited onto intronless mRNAs is largely unknown. We previously showed that Aly/REF is preferentially associated with intronless mRNAs in the nucleus. Here we show that Aly/REF could preferentially bind intronless mRNAs in vitro and that this binding was stimulated by RNA helicase UAP56 in an ATP-dependent manner. Consistently, an ATP binding-deficient UAP56 mutant specifically inhibited mRNA export in Xenopus oocytes. Interestingly, ATP activated the RNA binding activity of UAP56 itself. ATP-bound UAP56 therefore bound to both RNA and Aly/REF, and as a result ATPase activity of UAP56 was cooperatively stimulated. These results are consistent with a model in which ATP-bound UAP56 chaperones Aly/REF onto RNA, ATP is then hydrolyzed, and UAP56 dissociates from RNA for the next round of Aly/REF recruitment. Our finding provides a mechanistic insight into how export factors are recruited onto mRNAs.

  13. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALI/ARDS

    Directory of Open Access Journals (Sweden)

    Surender Rajasekaran

    2012-01-01

    Full Text Available Introduction. In the first 48 hours of ventilating patients with acute lung injury (ALI/acute respiratory distress syndrome (ARDS, a multipronged approach including packed red blood cell (PRBC transfusion is undertaken to maintain oxygen delivery. Hypothesis. We hypothesized children with ALI/ARDS transfused within 48 hours of initiating mechanical ventilation would have worse outcome. The course of 34 transfused patients was retrospectively compared to 45 nontransfused control patients admitted to the PICU at Helen DeVos Children’s Hospital between January 1st 2008 and December 31st 2009. Results. Mean hemoglobin (Hb prior to transfusion was 8.2 g/dl compared to 10.1 g/dl in control. P/F ratio decreased from 135.4±7.5 to 116.5±8.8 in transfused but increased from 148.0±8.0 to 190.4±17.8 (P<0.001 in control. OI increased in the transfused from 11.7±0.9 to 18.7±1.6 but not in control. Ventilator days in the transfused were 15.6±1.7 versus 9.5±0.6 days in control (P<0.001. There was a trend towards higher rates of MODS in transfused patients; 29.4% versus 17.7%, odds ratio 1.92, 95% CI; 0.6–5.6 Fisher exact P<0.282. Conclusion. This study suggests that early transfusions of patients with ALI/ARDS were associated with increased ventilatory needs.

  14. Summary of current radiometric calibration coefficients for Landsat MSS, TM, ETM+, and EO-1 ALI sensors

    Science.gov (United States)

    Chander, G.; Markham, B.L.; Helder, D.L.

    2009-01-01

    This paper provides a summary of the current equations and rescaling factors for converting calibrated Digital Numbers (DNs) to absolute units of at-sensor spectral radiance, Top-Of-Atmosphere (TOA) reflectance, and at-sensor brightness temperature. It tabulates the necessary constants for the Multispectral Scanner (MSS), Thematic Mapper (TM), Enhanced Thematic Mapper Plus (ETM+), and Advanced Land Imager (ALI) sensors. These conversions provide a basis for standardized comparison of data in a single scene or between images acquired on different dates or by different sensors. This paper forms a needed guide for Landsat data users who now have access to the entire Landsat archive at no cost.

  15. The Persian legend of ophthalmology: Ali Asghar Khodadoust and his everlasting lines.

    Science.gov (United States)

    Sajjadi, Sepideh; Fesharaki, Hamid; Abtahi, Zahra-Alsadat; Murray, Richard T; Fereidan-Esfahani, Mahboobeh; Mazloumi, Mehdi; Abtahi, Seyed-Hossein

    2013-06-01

    This is a brief celebratory overview of the fruitful life and scientific endeavors of Professor Ali Asghar Khodadoust (b.1935), a world renowned ophthalmologist, Persian icon of modern ophthalmology and an international pioneer of eye research. The global reputation of Dr. Khodadoust is rooted in his extensive studies on corneal diseases and transplantation biology. As a result of his truly deserved world renown, several famous American ophthalmologists have recognized him as the world's best corneal graft surgeon. Due to his exceptionally impressive achievements in this field, a clinical finding has been named in his honor, the "Khodadoust rejection line", a sign indicative of a chronic focal transplant reaction.

  16. ALIED: Una teoría de la detección de mentiras

    OpenAIRE

    2016-01-01

    En general, somos torpes a la hora de detectar mentiras y tendemos a creer que los demás dicen la verdad con más frecuencia de la que deberíamos. De hecho, los estudios sobre detección de mentiras suelen describir nuestra tendencia a creer a otras personas como un error de juicio. Aunque parezcamos irremediablemente malos a la hora de detectar mentiras, la teoría del Detector de Mentiras Adaptativo (ALIED) afirma que, en realidad, hacemos juicios inteligentes y bien informados. Este artículo ...

  17. A Glance at Mohammad Ali Bahmani’s Innovation in the Form of Sonnet

    Directory of Open Access Journals (Sweden)

    f Modaressi

    2012-09-01

    Innovation and violation of ordinary norms in the form of poem are among the resources to which the poet may resort in the process of poem composition. In effect, these resources can provide the poets with a unique style. As long as the poet observes unity and coherence in his poem, his innovation will enable him to avoid repeated poems. Mohammad Ali Bahmani is one of the contemporary lyricists who has made an efficient use of innovation in the form of sonnet in an attempt to reserve his discourse chain. The present study tries to investigate different types of Bahmani’s innovation in the form of sonnet.

  18. Odonata (Insecta diversity of Salim Ali Bird Sanctuary and its adjacent areas in Thattekkad, Kerala, India

    Directory of Open Access Journals (Sweden)

    A.P. Varghese

    2014-06-01

    Full Text Available Odonata diversity of Salim Ali Bird Sanctuary and its adjacent areas in Thattekkad, Kerala, India were documented from 2010 to 2012. Opportunistic observations were carried out to record species diversity. Eighty-two species of Odonata, which included 51 species of Anisoptera (dragonflies and 31 species of Zygoptera (damselflies, were recorded during the study. Of this 21 species are endemic to the Western Ghats. The presence of the IUCN categorized nearly threatened species like Megalogomphus hannyngtoni and vulnerable species like Platysticta deccanensis and Protosticta sanguinostigma is remarkable.

  19. A Comparison of Land Surface Water Mapping Using the Normalized Difference Water Index from TM, ETM+ and ALI

    Directory of Open Access Journals (Sweden)

    Bingyu Sun

    2013-10-01

    Full Text Available Remote sensing has more advantages than the traditional methods of land surface water (LSW mapping because it is a low-cost, reliable information source that is capable of making high-frequency and repeatable observations. The normalized difference water indexes (NDWIs, calculated from various band combinations (green, near-infrared (NIR, or shortwave-infrared (SWIR, have been successfully applied to LSW mapping. In fact, new NDWIs will become available when Advanced Land Imager (ALI data are used as the ALI sensor provides one green band (Band 4, two NIR bands (Bands 6 and 7, and three SWIR bands (Bands 8, 9, and 10. Thus, selecting the optimal band or combination of bands is critical when ALI data are employed to map LSW using NDWI. The purpose of this paper is to find the best performing NDWI model of the ALI data in LSW map. In this study, eleven NDWI models based on ALI, Thematic Mapper (TM, and Enhanced Thematic Mapper Plus (ETM+ data were compared to assess the performance of ALI data in LSW mapping, at three different study sites in the Yangtze River Basin, China. The contrast method, Otsu method, and confusion matrix were calculated to evaluate the accuracies of the LSW maps. The accuracies of LSW maps derived from eleven NDWI models showed that five NDWI models of the ALI sensor have more than an overall accuracy of 91% with a Kappa coefficient of 0.78 of LSW maps at three test sites. In addition, the NDWI model, calculated from the green (Band 4: 0.525–0.605 μm and SWIR (Band 9: 1.550–1.750 μm bands of the ALI sensor, namely NDWIA4,9, was shown to have the highest LSW mapping accuracy, more than the other NDWI models. Therefore, the NDWIA4,9 is the best indicator for LSW mapping of the ALI sensor. It can be used for mapping LSW with high accuracy.

  20. Ab-initio study of phase stability, elastic and thermodynamic properties of AlY alloy under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Dawei [College of Physics and Electronic Engineering, Nanyang Normal University, Nanyang 473061 (China); Su, Taichao [Institute of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000 (China); Song, Haizhen; Lu, Cheng; Zhong, Zhiguo; Lu, Zhiwen [College of Physics and Electronic Engineering, Nanyang Normal University, Nanyang 473061 (China); Pu, Chunying, E-mail: puchunying@126.com [College of Physics and Electronic Engineering, Nanyang Normal University, Nanyang 473061 (China)

    2015-11-05

    Using the particle swarm optimization algorithm combined with first-principles methods, we explore the diagram of AlY alloy up to 250 GPa. It is found that AlDy phase, rather than the experimentally observed B2 phase, is the most stable structure at 0 K and 0–20 GPa. However, our results show that B2 phase can exist as a stable phase at 20–27.6 GPa. At higher pressure, four new high-pressure phases with Cmcm-I, Cmcm-II, I4/mmm and P4/nmm structure are identified for the first time. The hardness, elastic and thermodynamic properties of the newly found phases are investigated and compared with B2 phase. The calculated hardness of AlDy, Cmcm-I, Cmcm-II, I4/mmm and P4/nmm phases is in the range of 7–9 GPa, higher than that of B2 phase. In addition, it is found that AlDy phase is a brittle material at 0 GPa, which changes to a ductile material above 12 GPa. Except for AlDy phase, all the other AlY compounds exhibit completely ductile behavior under pressure. Compared with the other phases, B2 phase is found to have the best ductility and the largest elastic anisotropy over the whole pressure investigated. Moreover, all AlY intermetallics exhibit a nearly elastic isotropy in compressibility but a comparatively large elastic anisotropy in shear. The structural stability, electronic structure, bulk and shear modulus, Debye temperature as well as sound velocities of AlY alloy under pressure are also deeply discussed. - Graphical abstract: Pressure-induced phase transition of AlY alloy up to 250 GPa. - Highlights: • The diagram of AlY alloy was explored and four new stable phases were predicted. • B2 phase shows the largest ductility and elastic anisotropy among AlY alloys. • All AlY alloys exhibit ductile behavior except for AlDy phase under pressure. • All AlY alloys show strong isotropy in compressibility and anisotropy in shear.

  1. Phytochemical screening and In vitro antioxidant activity of Paracalyx scariosa (Roxb Ali

    Directory of Open Access Journals (Sweden)

    RAMOJI ALLA

    2014-06-01

    Full Text Available Paracalyx scariosa (Roxb. Ali. also called as Paracalyx scariosus and cylista scariosa is a woody twiners belongs to the family Fabaceae is one of the important medicinal plant distributed in Central Provinces, West and South India, and Upper Burma. It is woody twiners with tomentose branches and stems finely downy. Leaves are 3-foliate with rhachis prolonged 6-13mm. between the insertion of the leaflets and stipels of the terminal one. The objective of this study is to explore the phytochemistry and the antioxidant potential of various extracts of Paracalyx scariosa (Roxb. Ali which is considered traditionally as an important medicinal plant. The preliminary phytochemical analysis was done to find out the presence of various bioactive compounds and TLC was performed to identify the no of flavonoids present. In vitro antioxidant analysis of methanol, acetone, benzene extracts and ethyl acetate , aqueous fractions of methanol extract was carried out by DPPH assay and Nitric oxide assay. It is observed from the phytochemical study, carbohydrates, proteins, saponins, triterpenoids, flavonoids and alkaloids are present in all the three extracts and Ethyl acetate fraction, benzene extract were separated in to 5 spots identified by bluish black colour confirming the presence of 5 types of flavonoids and the Acetone extract was not separated. Besides the extracts and fractions also possess strong antioxidant activity

  2. Ali Canip Yöntem’in Sanata ve Edebiyata Bakışı Ali Canip Yöntem’s Perspective to Art and Literature

    Directory of Open Access Journals (Sweden)

    Abdullah HARMANCI

    2012-09-01

    Full Text Available Ali Canip Yöntem (1887-1967 who is one of the prominent names of the national literary movement gave many works relating to literary theory and criticism as well as poem. Before being connected to national literary, author who has largely been seeking on the line extending from Muallim Naci to Cedideci (New Literature movement and Fecr-i Aticis (Dawn of the Future has deep thoughts in his many articles that will light the way for today’s artists and researchers either due to hiscommand of our classical literature or of Western Literature. From hiswritings in question, in our article, opinions of Yöntem about somematters such as what is the art and literature, why it is existing, whatcould be its power and effect, how to take advantage of art andliterature, the place and importance of the imitation in art, pleasure,beauty, perception and genius concepts, purpose of art, relationshipbetween artist and school of art, art and dialectic, poem and knowledge,poem and sensation etc were scanned and these opinions were whollyattempted to be assessed. Apart from these, problems collected undersome titles such as what, in fact, is the concept of national literature adhow it should be understood, our mistakes when assessing the concept“national”, dimensions of artist and public when assessing within thecontext of national literature have been the topic of the Ali CanipYöntem’s articles and opinions of author about these issues wereattempted to be examined by us. Yöntem also referred to the problemsabout limits of literary criticism and features which a reviewer musthave, and attached importance to the relationship of literary criticismwith literary text. Milli edebiyat akımının önde gelen isimlerinden olan Ali Canip Yöntem (1887 – 1967, şiirin yanı sıra edebiyat teorisine ve eleştirisine ilişkin eserler de vermiştir. Milli edebiyata mensup olmadan önce, Muallim Naci’den Edebiyatı Cedidecilere, Fecr-i Âticilere uzanan

  3. His Excellency Mr Ali Naci Koru Ambassador extraordinary and plenipotentiary Permanent Representative of Turkey to the United Nations Office at Geneva and other international organisations in Switzerland

    CERN Multimedia

    Bennett, Sophia Elizabeth

    2017-01-01

    His Excellency Mr Ali Naci Koru Ambassador extraordinary and plenipotentiary Permanent Representative of Turkey to the United Nations Office at Geneva and other international organisations in Switzerland

  4. Land cover mapping with emphasis to burnt area delineation using co-orbital ALI and Landsat TM imagery

    Science.gov (United States)

    Petropoulos, George P.; Kontoes, Charalambos C.; Keramitsoglou, Iphigenia

    2012-08-01

    In this study, the potential of EO-1 Advanced Land Imager (ALI) radiometer for land cover and especially burnt area mapping from a single image analysis is investigated. Co-orbital imagery from the Landsat Thematic Mapper (TM) was also utilised for comparison purposes. Both images were acquired shortly after the suppression of a fire occurred during the summer of 2009 North-East of Athens, the capital of Greece. The Maximum Likelihood (ML), Artificial Neural Networks (ANNs) and Support Vector Machines (SVMs) classifiers were parameterised and subsequently applied to the acquired satellite datasets. Evaluation of the land use/cover mapping accuracy was based on the error matrix statistics. Also, the McNemar test was used to evaluate the statistical significance of the differences between the approaches tested. Derived burnt area estimates were validated against the operationally deployed Services and Applications For Emergency Response (SAFER) Burnt Scar Mapping service. All classifiers applied to either ALI or TM imagery proved flexible enough to map land cover and also to extract the burnt area from other land surface types. The highest total classification accuracy and burnt area detection capability was returned from the application of SVMs to ALI data. This was due to the SVMs ability to identify an optimal separating hyperplane for best classes' separation that was able to better utilise ALI's advanced technological characteristics in comparison to those of TM sensor. This study is to our knowledge the first of its kind, effectively demonstrating the benefits of the combined application of SVMs to ALI data further implying that ALI technology may prove highly valuable in mapping burnt areas and land use/cover if it is incorporated into the development of Landsat 8 mission, planned to be launched in the coming years.

  5. FAMoS - an information service on the usage of data files in AliEn

    Science.gov (United States)

    Abramyan, A.; Betev, L.; Buncic, P.; Grigoras, C.; Grigoryan, A.; Manukyan, N.; Pedreira, M. M.; Saiz, P.

    2015-05-01

    The File Access Monitoring Service (FAMoS) leverages the information stored in the central AliEn file catalogue, which describes every file in a Unix-like directory structure, as well as metadata on file location and its replicas. In addition, it uses the access information provided by a set of API servers, used by all Grid clients to access the catalogue. The main functions of FAMoS are to sort the file accesses by logical groups, access time, user and storage element. The collected data identifies rarely used groups of files, as well as those with high popularity over different time periods. This information can be further used to optimize file distribution and replication factors, thus increasing the data processing efficiency. The paper describes the FAMoS structure and user interface and presents the results obtained in one year of service operation.

  6. Reconnectionless CME eruption: putting the Aly-Sturrock conjecture to rest

    CERN Document Server

    Rachmeler, L A; Kankelborg, C C

    2008-01-01

    We demonstrate that magnetic reconnection is not necessary to initiate fast CMEs. The Aly-Sturrock conjecture states that the magnetic energy of a given force free boundary field is maximized when the field is open. This is problematic for CME initiation because it leaves little or no magnetic energy to drive the eruption, unless reconnection is present to allow some of the field to escape without opening. Thus, it has been thought that reconnection must be present to initiate CMEs. This theory has not been subject to rigorous numerical testing because conventional MHD numerical models contain numerical diffusion, which introduces uncontrolled numerical reconnection. We use a quasi-Lagrangian simulation technique to run the first controlled experiments of CME initiation in the complete lack of reconnection. We find that a flux rope confined by an arcade, when twisted beyond a critical amount, can escape to an open state, allowing some of the surrounding arcade to shrink and releasing magnetic energy from the ...

  7. De IPR-bepalingen in de ALI/UNIDROIT Principles of transnational civil procedure. : Een bruikbaar model voor harmonisatie?

    NARCIS (Netherlands)

    X.E. Kramer (Xandra)

    2009-01-01

    textabstractIn deze bijdrage worden de nog weinig onderzochte bepalingen van de ALI/UNIDROIT Principles of transnational civil procedure bekeken die relevant zijn voor het internationaal privaatrecht. Deze Principles worden afgezet tegen bestaande internationale en Nederlandse IPR-regels. Voorts wor

  8. The DUB-ious lack of ALIS in Salmonella infection: a Salmonella deubiquitinase regulates the autophagy of protein aggregates.

    Science.gov (United States)

    Thomas, Mair; Mesquita, Francisco S; Holden, David W

    2012-12-01

    Ubiquitinated aggregates are formed in eukaryotic cells in response to several external stimuli, including exposure to bacterial lipopolysaccharide (LPS). Although Salmonella enterica serovar Typhimurium (S. Typhimurium) LPS has been shown to induce aggresome-like induced structures (ALIS) in macrophages, these have not been described in S. Typhimurium-infected macrophages. Given that LPS is present in infection, this suggests that S. Typhimurium might suppress the formation of ALIS. We found that S. Typhimurium induces the formation of ubiquitinated aggregates in epithelial cells and macrophages, but that their presence is masked by the deubiquitinase (DUB) activity of the S. Typhimurium virulence protein, SseL. SseL deubiquitinates SQSTM1/p62-bound proteins found in S. Typhimurium-induced aggregates and ALIS, and reduces the recruitment of autophagic components. While the functions of ALIS and other ubiquitinated aggregates remain unclear, they serve to sequester cytosolic proteins under a variety of stress conditions and are suggested to be involved in host immune defense. During infection, the deubiquitinase activity of SseL reduces autophagic flux in infected cells and favors bacterial replication. This is a new example of how a bacterial pathogen counteracts the autophagy pathway through the action of a translocated virulence protein.

  9. The Ali Rajas of Cannanore : status and identity at the interface of commercial and political expansion, 1663-1723

    NARCIS (Netherlands)

    John, Binu Mailaparambil

    2007-01-01

    The present study focuses on the Mappila Muslim trading elites in the port city of Cannanore, particularly the Arackal Ali Rajas, on the south-west coast of India and their response to the shifting power relations in the region brought about by the changes in the Indian Ocean maritime trade scenario

  10. The Relation of UCCE and Politics in the Period of Ali Coşkun's Presidential Term at UCCE

    Directory of Open Access Journals (Sweden)

    Hüseyin ÇAVUŞOĞLU

    2011-06-01

    Full Text Available One can see that during the period between establishment of Turkish Union of Chambers and Exchange Commodities (TOBB (6 February 1952 and Mehmet Yazar’s presidency of Turkish Union of Chambers (27 May 1979 Democratic Party and Justice Party dominated the Union of Chambers. During Mehmet Yazar’s presidency period of TOBB (27 May 1979 – 4 April 1985 relationship between TOBB and Mother Land Party (ANAP became problematic, and in contrast to the previous periods the TOBB became an independent foundation and gained significant contributions in being a group of interest and reached a substantial economical power. In Ali Coskun’s presidency period of TOBB (4 June 1986 – 30 May 1990, on the other hand, one might see that ANAP dominated the TOBB, and TOBB lost its independence and couldn’t make significant proceedings in being a group of interest. In the same period, ANAP government made steps in direction of requests from the TOBB. As in the previous periods, during Ali Coskun’s presidency period a lot of people entered policy from the central-right parties (ANAP and True Path Party, DYP. Aim of the present study was to discuss the relationship between political power and Union of Chambers during Ali Coskun’s presidency period of TOBB and Ali Coskun’s presidency period’s differences from and similarities with the previous periods.

  11. An Approach to the Stories of Sabahattin Ali within the Context of Marxist Literary Aesthetics: The Conflict between Peasants and the Intelligentsia

    Science.gov (United States)

    Yigit, Murat

    2016-01-01

    This study will try to read the stories of Sabahattin Ali, who has written various books in Turkish, within the context of Marxist literary aesthetics, assess the types and characters in the stories of Sabahattin Ali within that framework, and observe the social levels and the gaps between them based on the relationships between the two extreme…

  12. Characterization of an Alginate Lyase, FlAlyA, from Flavobacterium sp. Strain UMI-01 and Its Expression in Escherichia coli

    Directory of Open Access Journals (Sweden)

    Akira Inoue

    2014-08-01

    Full Text Available A major alginate lyase, FlAlyA, was purified from the periplasmic fraction of an alginate-assimilating bacterium, Flavobacterium sp. strain UMI-01. FlAlyA showed a single band of ~30 kDa on SDS-PAGE and exhibited the optimal temperature and pH at 55 °C and pH 7.7, respectively. Analyses for substrate preference and reaction products indicated that FlAlyA was an endolytic poly(mannuronate lyase (EC 4.2.2.3. A gene fragment encoding the amino-acid sequence of 288 residues for FlAlyA was amplified by inverse PCR. The N-terminal region of 21 residues except for the initiation Met in the deduced sequence was predicted as the signal peptide and the following region of six residues was regarded as propeptide, while the C-terminal region of 260 residues was regarded as the polysaccharide-lyase-family-7-type catalytic domain. The entire coding region for FlAlyA was subjected to the pCold I—Escherichia coli BL21(DE3 expression system and ~eight times higher yield of recombinant FlAlyA (recFlAlyA than that of native FlAlyA was achieved. The recFlAlyA recovered in the periplasmic fraction of E. coli had lost the signal peptide region along with the N-terminal 3 residues of propeptide region. This suggested that the signal peptide of FlAlyA could function in part in E. coli.

  13. NILAI–NILAI PENDIDIKAN AKHLAK DALAM AL QUR’AN SURAT ALI IMRAN AYAT 159-160

    Directory of Open Access Journals (Sweden)

    Armin Nurhartanto

    2015-12-01

    Full Text Available The background of this research is the phenomenon of teenagers’ moral degenerate which the writer found. Considering the importance of al Qur’an for all people, it is important to implement its values as a concern especially for muslim, so the moral values in al Qur’an can be taught to the people in a good way. From this state, the writer is interested in exploring deeper about moral values in al Qur’an surah Ali Imran 159 – 160. The goals of the research are ; 1 to know the moral values in al Qur’an Surah Ali Imran 159 – 160, 2 to know how the concept of moral value in those verses, 3 to know the implication of those verses for Islamic Education in school. The research is a library research. Primier data source is al Qur’an Surah Ali Imran 159 – 160. The second data sources are book, articles or works about moral values and the implementation of moral values, considered to be true, both in sentences or content. Approaches which are used are didactic – psychology and thematic combined with qualitative analysis and are reprocessed by using deductive, inductive and comparative analysis. The result of the research show that ; 1 moral values reflected in Surah Ali Imran 159 – 160 are graceful, forgiving, solving problem by discussing it with the people, believing in Allah and believing in Allah’s help. 2 in the concept of moral education, the way Rasulullah lead his companions, he prioritizes the graceful, dissscussion, although he holds the highest authotiry. The other moral values is believing in Allah. 3 the implication of the concept of moral education according to al Qur’an Surah Ali Imran 159-160 is the concept of moral-oriented teaching.  The recommendation of this research is how the school as an education institution is able to raise moral values reflected in al Qur’an Surah Ali Imran 159-160 to the student, so they can take the lesson from the prophet’s daily life. Keywords: moral; values; implication to

  14. [Acute respiratory insufficiency due to severe lung injury - ARDS and ALI].

    Science.gov (United States)

    Pfeifer, M

    2010-09-01

    As a consequence of the novel therapeutic option of mechanical ventilation in early intensive care medicine, the acute respiratory distress syndrome (ARDS) was defined as a disease entity of its own representing the most severe form of acute lung injury (ALI). Since its first description four decades ago, our knowledge about the aetiology, physiology, histology and epidemiology of this lethal pulmonary complication of severe acute diseases such as pneumonia or sepsis has been increasing steadily. The initial major therapeutic advances were due to improvements in intensive care medical procedures and monitoring. The large ARDS Network clinical trial on the magnitude of tidal volume impressively demonstrated the feasibility of targeted clinical trials in patients with ARDS that provide robust evidence in this field. This clinical trial, as well as following large-scale trials in ARDS patients, led to significant changes of ventilation therapy and therapeutic strategies that improve the outcome of this disease entity. Advances in the standardisation of care for ARDS patients involving innovative therapeutic procedures such as extracorporeal gas exchange systems will lead to a further improvement in ARDS management and outcome. Modern pulmonary medicine can play a pivotal role in this process and can contribute its rich experiences in all areas of the respiratory system.

  15. The Effect of Dramatized Instruction on Speaking Ability of Imam Ali University EFL Learners

    Directory of Open Access Journals (Sweden)

    Sadegh Khosronejad

    2013-09-01

    Full Text Available Teaching language as a second or foreign language, undoubtedly, is so demanding and seeking to find methods for facilitating this prominent practice whets the appetite of any practitioner who works in this field. Research shows that using drama in the classroom as a means of teaching helps students learn socially, academically, and developmentally. This study was an attempt to determine the effect of dramatized instruction on the speaking ability of EFL learners of Imam Ali University. Sixty EFL male students at the intermediate level participated in the study. Their age range was 19-22. Two instruments were utilized in this study; pretest, and posttest.  The data were analyzed through t-test. The data analysis indicated that the mean scores of the experimental group students (M = 72.80 were significantly different (3.29>2; df = 58 from the control group students (M = 65.39. In other words, the experimental group outperformed the control group in the posttest significantly. Moreover, the findings indicated that dramatized instruction does have a great effect on the speaking skills. This study supported the idea of effectiveness of dramatized instruction on developing speaking skill and the teachers can help the learners at lower levels promote their speaking skill through dramatized instruction in EFL classes. Key words: Drama, Dramatized Instruction, Conventional Methods

  16. Professor Mansour Ali Haseeb: Highlights from a pioneer of biomedical research, physician and scientist.

    Science.gov (United States)

    Salih, Mustafa Abdalla M

    2013-01-01

    The article highlights the career of Professor Mansour Ali Haseeb (1910 - 1973; DKSM, Dip Bact, FRCPath, FRCP [Lond]), a pioneer worker in health, medical services, biomedical research and medical education in the Sudan. After his graduation from the Kitchener School of Medicine (renamed, Faculty of Medicine, University of Khartoum [U of K]) in 1934, he devoted his life for the development of laboratory medicine. He became the first Sudanese Director of Stack Medical Research Laboratories (1952 - 1962). He made valuable contributions by his services in the vaccine production and implementation programs, most notably in combating small pox, rabies and epidemic meningitis. In 1963 he became the first Sudanese Professor of Microbiology and Parasitology and served as the first Sudanese Dean of the Faculty of Medicine, U of K (1963-1969). He was an active loyal citizen in public life and served in various fields outside the medical profession. As Mayor of Omdurman, he was invited to visit Berlin in 1963 by Willy Brandt, Mayor of West Berlin (1957-1966) and Chancellor of the Federal Republic of Germany (1969 to 1974). Also as Mayor of Omdurman, he represented the City in welcoming Queen Elizabeth II during her visit to Sudan in February 1965. He also received State Medals from Egypt and Ethiopia. In 1973 he was appointed Chairman of the Sudan Medical Research Council, and was awarded the international Dr. Shousha Foundation Prize and Medal by the WHO for his contribution in the advancement of health, research and medical services.

  17. Research advances in effect of perfluorocarbons on pro-inflammatory cytokines in treatment of ALI/ARDS%全氟化碳在治疗ALI/ARDS时对促炎因子影响的研究进展

    Institute of Scientific and Technical Information of China (English)

    唐瑾

    2014-01-01

    以全氟化碳(Perfluorocarbons,PFC)为通气媒介的部分液体通气技术是近年来新兴的治疗ALI/ARDS的技术,其中对促炎因子的抑制作用可能是保护机制之一.虽然目前有关PFC抗炎的分子机制尚未完全阐明,但细胞和动物实验充分证明了PFC可以拮抗ALI/ARDS的炎症反应,可临床研究却令人失望.本研究就近年来全氟化碳对促炎因子TNF-α、IL-1、IL-6、IL-8影响的相关研究进展进行综述.

  18. Greater self-enhancement in Western than Eastern Ukraine, but failure to replicate the Muhammad Ali effect.

    Science.gov (United States)

    Kemmelmeier, Markus; Malanchuk, Oksana

    2016-02-01

    Based on the cross-cultural research linking individualism-collectivism and self-enhancement, this research examines regional pattern of self-enhancement in Ukraine. Broadly speaking, the western part of Ukraine is mainly Ukrainian speaking and historically oriented towards Europe, whereas Eastern Ukraine is mainly Russian speaking and historically oriented towards the Russian cultural sphere. We found self-enhancement on a "better than average" task to be higher in a Western Ukrainian sample compared to an Eastern Ukrainian sample, with differences in independent self-construals supporting assumed regional variation in individualism. However, the Muhammad Ali effect, the finding that self-enhancement is greater in the domain of morality than intelligence, was not replicated. The discussion focuses on the specific sources of this regional difference in self-enhancement, and reasons for why the Muhammad Ali effect was not found.

  19. Said Ali e a acentuação: primórdios da Linguística no Brasil

    Directory of Open Access Journals (Sweden)

    Maria Mercedes Saraiva Hackerott

    2011-01-01

    Full Text Available Since his first articles in Revista Brazileira published in 1895, Manuel Said Ali Ida (1860-1953 gave priority to the synchronic study of the spoken language. He argues that dynamic accent (greater voice intensity and musical accent (pitch affect the meaning of the clause and demonstrate the interdependence of the phonetic, syntactic and semantic levels. In Portuguese, the word pronounced with most stress contains the main idea and is usually placed at the end of the clause. A change of word order or stress replacement draws the listener’s attention and facilitates the identification of new information by means of intonation. The introduction of phonetic criteria as a parameter of analysis separates Said Ali from the grammatical tradition of his time, making him the precursor of Brazilian linguistics. This essay in Linguistic Historiography seeks to trace in Said Ali’s work on accent the emergence of a new field of language study.

  20. The Use of Artistic Devices to Forward Female Oppression in Selected Short Stories by Muhammad ‘Ali Saeid

    Directory of Open Access Journals (Sweden)

    Jamal Ali Assadi

    2014-04-01

    Full Text Available This article studies three short stories by Muhammad Ali Saeid (1950-, a writer and critic who lives in Tamrah, the Western Galilee. These stories are “The Delivery” (Al Wilādah, “Ḥayāt” (life, and “Devouring” (Iftirās, which appeared in Assadi’s Father and Son: Selected Short Fiction by Hanna Ibrahim Elias and Mohammad Ali Saeid. It examines the use of the artistic devices used in the selected short stories to highlight “female oppression” as well as the linkage between feminism and post-colonialism, in case of Palestine. Above all, this article confirms that the profound perceptions of Saeid are reflected in his success to control his narrative techniques so artistically that he offers new arenas for academic assessments and analysis. Saeid’s observations also brighten new terrains, where divergent powers can band tunefully to battle subjugation, prejudice, and occupation.

  1. Review: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future perspectives of therapies

    Institute of Scientific and Technical Information of China (English)

    LUH Shi-ping; CHIANG Chi-huei

    2007-01-01

    Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), which manifests as non-cardiogenic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung.Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies.

  2. Cellular Nuclear Export Factors TAP and Aly Are Required for HDAg-L-mediated Assembly of Hepatitis Delta Virus.

    Science.gov (United States)

    Huang, Hsiu-Chen; Lee, Chung-Pei; Liu, Hui-Kang; Chang, Ming-Fu; Lai, Yu-Heng; Lee, Yu-Ching; Huang, Cheng

    2016-12-09

    Hepatitis delta virus (HDV) is a satellite virus of hepatitis B virus (HBV). HDV genome encodes two forms of hepatitis delta antigen (HDAg), small HDAg (HDAg-S), which is required for viral replication, and large HDAg (HDAg-L), which is essential for viral assembly. HDAg-L is identical to HDAg-S except that it bears a 19-amino acid extension at the C terminus. Both HDAgs contain a nuclear localization signal (NLS), but only HDAg-L contains a CRM1-independent nuclear export signal at its C terminus. The nuclear export activity of HDAg-L is important for HDV particle formation. However, the mechanisms of HDAg-L-mediated nuclear export of HDV ribonucleoprotein are not clear. In this study, the host cellular RNA export complex TAP-Aly was found to form a complex with HDAg-L, but not with an export-defective HDAg-L mutant, in which Pro(205) was replaced by Ala. HDAg-L was found to colocalize with TAP and Aly in the nucleus. The C-terminal domain of HDAg-L was shown to directly interact with the N terminus of TAP, whereas an HDAg-L mutant lacking the NLS failed to interact with full-length TAP. In addition, small hairpin RNA-mediated down-regulation of TAP or Aly reduced nuclear export of HDAg-L and assembly of HDV virions. Furthermore, a peptide, TAT-HDAg-L(198-210), containing the 10-amino acid TAT peptide and HDAg-L(198-210), inhibited the interaction between HDAg-L and TAP and blocked HDV virion assembly and secretion. These data demonstrate that formation and release of HDV particles are mediated by TAP and Aly.

  3. ALICE distributed analysis of the K*(892)0 signal in pp events with the AliEn package

    Energy Technology Data Exchange (ETDEWEB)

    Badala, A. [INFN, Sezione di Catania, Catania (Italy); Barbera, R. [INFN, Sezione di Catania, Catania (Italy); Dipartimento di Fisica e Astronomia, Universita di Catania, Catania (Italy); Lo Re, G. [CNAF, Bologna (Italy)]. E-mail: giuseppe.lore@cnaf.infn.it; Palmeri, A. [INFN, Sezione di Catania, Catania (Italy); Pappalardo, G.S. [INFN, Sezione di Catania, Catania (Italy); Pulvirenti, A. [INFN, Sezione di Catania, Catania (Italy); Dipartimento di Fisica e Astronomia, Universita di Catania, Catania (Italy); Riggi, F. [INFN, Sezione di Catania, Catania (Italy); Dipartimento di Fisica e Astronomia, Universita di Catania, Catania (Italy)

    2004-11-21

    A simulation study concerning the K*(892)0 resonance was carried out within the ALICE Collaboration, in order to evaluate the capability of the detector in the reconstruction of this signal in pp collisions at the Large Hadron Collider (LHC) energy. A description of the analysis procedure which makes use of AliEn, the ALICE package for distributed computing, is given together with the obtained results.

  4. ALICE distributed analysis of the $K^{*}(892)^{0}$ signal in pp events with the AliEn package

    CERN Document Server

    Badalà, A; Palmeri, A; Pappalardo, G S; Pulvirenti, A; Lo Re, G; Riggi, F

    2004-01-01

    A simulation study concerning the K*(892)**0 resonance was carried out within the ALICE Collaboration, in order to evaluate the capability of the detector in the reconstruction of this signal in pp collisions at the Large Hadron Collider (LHC) energy. A description of the analysis procedure which makes use of AliEn, the ALICE package for distributed computing, is given together with the obtained results.

  5. Mapping forest height, foliage height profiles and disturbance characteristics with time series of gap-filled Landsat and ALI imagery

    Science.gov (United States)

    Helmer, E.; Ruzycki, T. S.; Wunderle, J. M.; Kwit, C.; Ewert, D. N.; Voggesser, S. M.; Brandeis, T. J.

    2011-12-01

    We mapped tropical dry forest height (RMSE = 0.9 m, R2 = 0.84, range 0.6-7 m) and foliage height profiles with a time series of gap-filled Landsat and Advanced Land Imager (ALI) imagery for the island of Eleuthera, The Bahamas. We also mapped disturbance type and age with decision tree classification of the image time series. Having mapped these variables in the context of studies of wintering habitat of an endangered Nearctic-Neotropical migrant bird, the Kirtland's Warbler (Dendroica kirtlandii), we then illustrated relationships between forest vertical structure, disturbance type and counts of forage species important to the Kirtland's Warbler. The ALI imagery and the Landsat time series were both critical to the result for forest height, which the strong relationship of forest height with disturbance type and age facilitated. Also unique to this study was that seven of the eight image time steps were cloud-gap-filled images: mosaics of the clear parts of several cloudy scenes, in which cloud gaps in a reference scene for each time step are filled with image data from alternate scenes. We created each cloud-cleared image, including a virtually seamless ALI image mosaic, with regression tree normalization of the image data that filled cloud gaps. We also illustrated how viewing time series imagery as red-green-blue composites of tasseled cap wetness (RGB wetness composites) aids reference data collection for classifying tropical forest disturbance type and age.

  6. FAUNAL CHANGE NEAR THE END-PERMIAN EXTINCTION: THE BRACHIOPODS OF THE ALI BASHI MOUNTAINS, NW IRAN

    Directory of Open Access Journals (Sweden)

    ABBAS GHADERI

    2014-03-01

    Full Text Available The Julfa Formation in the Ali Bashi Mountains, northwest Iran, is very rich in brachiopods, particularly in its lower part, which has been dated by fusulinids and conodonts as Wuchiapingian in age. The brachiopod fauna described herein has been collected along the Main Valley section of the Ali Bashi Mountains, several hundred metres away from the historical sections described in the 1960’s and 1970’s. It comprises 39 species of the orders Productida, Orthotetida, Orthida, Rhynchonellida, Athyridida, Spiriferida, and Terebratulida, most of which are known in the coeval successions of Transcaucasia, Alborz Mountains in north Iran and in South China, confirming the Wuchiapingian age indicated by other proxies. A few of the brachiopod taxa range up into the Changhsingian Paratirolites Limestone. The shale and marly limestone at the base of the formation are dominated by semi-infaunal productids, that are progressively succeeded near the top of the lower part of the formation by a more diverse range of pedicle attached and cemented taxa, suggesting a shallowing upward trend and a shift to higher nutrient-substrates in more turbulent waters. The successive deepening trend recorded in the upper part of the Julfa Formation and in the overlying Ali Bashi Formation is very unfavourable for the brachiopods and only a few species survive, represented by small sized pediculate taxa that thrive on hardgrounds.

  7. A study of fine structure of diffuse aurora with ALIS-FAST measurements

    Directory of Open Access Journals (Sweden)

    T. Sergienko

    2008-10-01

    Full Text Available We present results of an investigation of the fine structure of the night sector diffuse auroral zone, observed simultaneously with optical instruments (ALIS from the ground and the FAST electron spectrometer from space 16 February 1997. Both the optical and particle data show that the diffuse auroral zone consisted of two regions. The equatorward part of the diffuse aurora was occupied by a pattern of regular, parallel auroral stripes. The auroral stripes were significantly brighter than the background luminosity, had widths of approximately 5 km and moved southward with a velocity of about 100 m/s. The second region, located between the region with auroral stripes and the discrete auroral arcs to the north, was filled with weak and almost homogeneous luminosity, against which short-lived auroral rays and small patches appeared chaotically. From analysis of the electron differential fluxes corresponding to the different regions of the diffuse aurora and based on existing theories of the scattering process we conclude the following: Strong pitch angle diffusion by electron cyclotron harmonic waves (ECH of plasma sheet electrons in the energy range from a few hundred eV to 3–4 keV was responsible for the electron precipitation, that produced the background luminosity within the whole diffuse zone. The fine structure, represented by the auroral stripes, was created by precipitation of electrons above 3–4 keV as a result of pitch angle diffusion into the loss cone by whistler mode waves. A so called "internal gravity wave" (Safargaleev and Maltsev, 1986 may explain the formation of the regular spatial pattern formed by the auroral stripes in the equatorward part of the diffuse auroral zone.

  8. A study of fine structure of diffuse aurora with ALIS-FAST measurements

    Science.gov (United States)

    Sergienko, T.; Sandahl, I.; Gustavsson, B.; Andersson, L.; Brändström, U.; . Steen, Ã.

    2008-10-01

    We present results of an investigation of the fine structure of the night sector diffuse auroral zone, observed simultaneously with optical instruments (ALIS) from the ground and the FAST electron spectrometer from space 16 February 1997. Both the optical and particle data show that the diffuse auroral zone consisted of two regions. The equatorward part of the diffuse aurora was occupied by a pattern of regular, parallel auroral stripes. The auroral stripes were significantly brighter than the background luminosity, had widths of approximately 5 km and moved southward with a velocity of about 100 m/s. The second region, located between the region with auroral stripes and the discrete auroral arcs to the north, was filled with weak and almost homogeneous luminosity, against which short-lived auroral rays and small patches appeared chaotically. From analysis of the electron differential fluxes corresponding to the different regions of the diffuse aurora and based on existing theories of the scattering process we conclude the following: Strong pitch angle diffusion by electron cyclotron harmonic waves (ECH) of plasma sheet electrons in the energy range from a few hundred eV to 3 4 keV was responsible for the electron precipitation, that produced the background luminosity within the whole diffuse zone. The fine structure, represented by the auroral stripes, was created by precipitation of electrons above 3 4 keV as a result of pitch angle diffusion into the loss cone by whistler mode waves. A so called "internal gravity wave" (Safargaleev and Maltsev, 1986) may explain the formation of the regular spatial pattern formed by the auroral stripes in the equatorward part of the diffuse auroral zone.

  9. Multi-source image reconstruction: exploitation of EO-1/ALI in Landsat-7/ETM+ SLC-off gap filling

    Science.gov (United States)

    Darvishi Boloorani, Ali; Erasmi, Stefan; Kappas, Martin

    2008-02-01

    The Landsat-7 Enhanced Thematic Mapper Plus (ETM+) is the sensor payload on the Landsat-7 satellite imager (launched on April 15th, 1999) that is a derivative of the Landsat-4 and 5 Thematic Mapper (TM) land imager sensors. Scan Line Corrector (SLC) malfunctioning appeared onboard on May 31, 2003. The SLC-Off problem was caused by failure of the SLC which compensates for the forward motion of the satellite [1]. As ETM+ is still capable of acquiring images with the SLC-Off mode, the need of applying new techniques and using other data sources to reconstruct the missed data is a challenging for scientists and final users of remotely sensed images. One of the predicted future roles of the Advanced Land Imager (ALI) onboard the Earth Observer One (EO-1) is its ability to offer a potential technological direction for Landsat data continuity missions [2]. In this regard more than the purposes of the work as fabricating the gapped area in the ETM+ the attempt to evaluate the ALI imagery ability is another noticeable point in this work. In the literature there are several techniques and algorithms for gap filling. For instance local linear histogram matching [3], ordinary kriging, and standardized ordinary cokriging [4]. Here we used the Regression Based Data Combination (RBDC) in which it is generally supposed that two data sets (i.e. Landsat/ETM+ and EO-1/ALI) in the same spectral ranges (for instance band 3 ETM+ and band 4 ALI in 0.63 - 0.69 μm) will have meaningful and useable statistical characteristics. Using this relationship the gap area in ETM+ can be filled using EO-1/ALI data. Therefore the process is based on the knowledge of statistical structures of the images which is used to reconstruct the gapped areas. This paper presents and compares four regression based techniques. First two ordinary methods with no improvement in the statistical parameters were undertaken as Scene Based (SB) and Cluster Based (CB) followed by two statistically developed algorithms

  10. Effects of Xuebijing on Nitric Oxide and VEGF-A in Exhaled Breath Condensate of Patients with ALI/ARDS%血必净对ALI/ARDS患者呼出气冷凝液中NO和VEGF-A的影响

    Institute of Scientific and Technical Information of China (English)

    薛垒喜; 陈建荣; 陶一江; 陈金亮; 徐志华; 蒋云书

    2013-01-01

    Objective To observe the clinical significance of changes of nitric oxide (NO) and vascular endothelial growth factor A (VEGF-A) in exhaled breath condensate (EBC) of patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) after they were treated by Xuebijing (XBJ),and to evaluate the effect of the EBC detection technology.Methods Totally 32 ALI/ARDS patients receiving mechanical ventilation at intensive care unit (ICU) were randomly assigned to the treatment group and the control group,16 cases in each group.Patients in the control group were treated by routine therapy,while those in the treatment group were treated by routine therapy + XBJ.The therapeutic course for all was 5 days.The EBC sample was collected by improved EcoScreen condenser within 24 h after confirmed diagnosis of ALI/ARDS and on the fifth day of medication.The levels of NO and VEGF-A were measured by EIA in EBC and serum.The changes of NO and VEGF-A in EBC were observed before and after treatment.Results Compared with before treatment,the level of NO in EBC and serum decreased and VEGF-A increased after treatment,showing statistical difference (P <0.05,P <0.01).After treatment the level of NO in EBC and serum was lower in the treatment group than in the control group (P <0.05).The VEGF-A in EBC was higher in the treatment group than in the control group (P <0.05).There was no statistical difference in the serum VEGF-A level between the two groups (P >0.05).Conclusions XBJ was an effective therapeutic drug capable to control the in vivo inflammation reaction in patients with ALI/ARDS.The detection of changes of VEGF-A and NO levels by EBC could judge the inflammatory reaction degree in ALI/ARDS patients,and help evaluating the therapeutic effect.%目的 研究急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者使用血必净治疗后呼出气冷凝液(exhaled breath condensate

  11. Plasma CC16 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia: a retrospective observational study

    Directory of Open Access Journals (Sweden)

    Lutter Rene

    2009-12-01

    Full Text Available Abstract Background Despite consensus criteria, diagnosing acute lung injury, or its more severe form acute respiratory distress syndrome (ALI/ARDS remains challenging. Adding objective measures, such as plasma levels of biological markers could facilitate recognition of ALI/ARDS. This study was designed to assess and compare the diagnostic accuracy of biological markers for ALI/ARDS with ventilator-associated pneumonia (VAP. Methods We performed serial measurements of Clara cell protein (CC16, soluble receptor for advanced glycation end products (sRAGE, surfactant protein D (SP-D and Krebs von den Lungen (KL-6 in plasma of patients with VAP and mechanically ventilated control patients without VAP. ALI/ARDS was diagnosed using the criteria of the North-American European consensus conference. Results Thirty-seven patients were enrolled - 22 patients with VAP and 15 control patients. Ten patients with pneumonia met the ALI/ARDS consensus criteria. Control patients never met these criteria. Plasma CC16 had a good diagnostic capacity for ALI/ARDS as shown by the receiver operating characteristic curve with an area under the curve of 0.91 (95% confidence interval (CI 0.79 - 1.00; p p = 0.02. The diagnostic accuracies of KL-6 and sRAGE were low. Conclusion Plasma CC16 seems a potential biological marker for ALI/ARDS in patients with VAP. Plasma levels of sRAGE, SP-D and KL-6 have limited discriminative power for diagnosing ALI/ARDS in VAP.

  12. 75 FR 2921 - In the Matter of the Designation of Said Ali al-Shihri, Also Known as Abu-Sayyaf, Also Known as...

    Science.gov (United States)

    2010-01-19

    ... Matter of the Designation of Said Ali al-Shihri, Also Known as Abu-Sayyaf, Also Known as Abu-Sufyan al-Azidi, Also Known as Abu-Sayyaf al-Shihri, Also Known as Abu Sufian Kadhdhaab Matrook, Also Known as Sa'id Ali Jabir al-Khathim al-Shihri, Also Known as Salad, Also Known as Abu Salah Abu Sufyan,...

  13. Mineral mapping on the Chilean-Bolivian Altiplano using co-orbital ALI, ASTER and Hyperion imagery: Data dimensionality issues and solutions

    Science.gov (United States)

    Hubbard, B.E.; Crowley, J.K.

    2005-01-01

    Hyperspectral data coverage from the EO-1 Hyperion sensor was useful for calibrating Advanced Land Imager (ALI) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) images of a volcanic terrane area of the Chilean-Bolivian Altiplano. Following calibration, the ALI and ASTER datasets were co-registered and joined to produce a 13-channel reflectance cube spanning the Visible to Short Wave Infrared (0.4-2.4 ??m). Eigen analysis and comparison of the Hyperion data with the ALI + ASTER reflectance data, as well as mapping results using various ALI+ASTER data subsets, provided insights into the information dimensionality of all the data. In particular, high spectral resolution, low signal-to-noise Hyperion data were only marginally better for mineral mapping than the merged 13-channel, low spectral resolution, high signal-to-noise ALI + ASTER dataset. Neither the Hyperion nor the combined ALI + ASTER datasets had sufficient information dimensionality for mapping the diverse range of surface materials exposed on the Altiplano. However, it is possible to optimize the use of the multispectral data for mineral-mapping purposes by careful data subsetting, and by employing other appropriate image-processing strategies.

  14. Aliénor, une infante entre la Castille, l’Aragon et le Portugal

    Directory of Open Access Journals (Sweden)

    Ana Maria S. A. RODRIGUES

    2008-07-01

    Full Text Available Aliénor (?-1445, fille de l’infant Ferdinand de Castille, est devenue infante d’Aragon par l’accession de son père à la couronne d’Aragon et princesse puis reine du Portugal par son mariage avec Édouard (1391-1438. Dans cette étude, nous essayons de démontrer qu’elle ne se contenta pas d’être un simple pion dans les jeux de pouvoir des hommes de ses deux familles – la famille d’origine et la famille d’alliance –, mais qu’elle y prit part activement sans pourtant manquer à ses obligations spécifiquement féminines. Elle mit au monde neuf enfants, garantissant ainsi la continuité dynastique et de fructueuses alliances avec d’autres monarchies, prodigua à son mari affection et conseils et assura la régence du royaume au nom de son fils, tout en gardant un contact étroit avec ses frères et les aidant le cas échéant. Elle fut pourtant déchue du pouvoir par ses beaux-frères. Abandonnée par les infants d’Aragon, elle mourut en exil dans un dénuement presque complet.Leonor (?-1445, hija del infante Fernando de Castilla, fue infanta de Aragón por la elevación de su padre a ese trono, princesa y luego reina de Portugal por su matrimonio con Eduardo (1391-1438. En este estudio, intentamos demostrar que ella no se contentó con ser un simple peón en los juegos de poder de los hombres de sus dos familias – la familia de origen y la familia de alianza – sino que participó en ellos activamente sin por eso faltar a sus deberes específicamente femeninos. Tuvo nueve hijos, garantizando así la continuidad dinástica y fructuosas alianzas con otras monarquías, prodigó a su marido afecto y consejos, y aseguró la regencia del reino en nombre de su hijo, guardando al mismo tiempo un contacto estrecho con sus hermanos y ayudándoles en caso de necesidad. Sin embargo fue descartada del poder por sus cuñados. Abandonada por los infantes de Aragón, murió en exilio en la más extrema necesidad.

  15. Study of the raw materials used in the manufacture of ceramics in Fran Ali (Oued Laou, Marruecos); Estudio de materiales usados en la fabricacion de las ceramicas de Fran Ali (Oued Laou, Marruecos)

    Energy Technology Data Exchange (ETDEWEB)

    Barrios Neira, J.; Martin de la Cruz, J. C.; Montealegre Contreras, L.

    2012-11-01

    The thermal behaviour, mineralogy, texture and micro-structure of the original rocks used as raw materials in the manufacture of ceramics of the potter community in Fran Ali (Oued Laou, Tetouan, Morocco) were studied. The original rocks of the alteration deposit are metapelites and altered philites from the Units Malaguide-Gomaride in the Baetic-Rifian mountain system. The techniques used by local potters and the water used to prepare the ceramic bodies were also studied. Original rocks are metapelites or filadios and raw materials belong to levels caused by exogenous or supergene alteration (quartz-illite and chlorite type clays). The ceramics studied by microscopy exhibit anisotropy. (Author) 15 refs.

  16. Permanentnost primitivne akumulacije, ali o privatni lastnini, komodifikaciji in povratku rente

    Directory of Open Access Journals (Sweden)

    Jernej Prodnik

    2011-06-01

    Full Text Available Namen teksta je prispevati k razumevanju ideje o skupnem v obstoječih zgodovinskih okvirih. Avtor opozarja na množico pomenov, ki jih je potrebno vzeti v ozir, ko poizkušamo konceptualizirati skupno, vsaj če ga hočemo razumeti kar se le da celovito. Tega koncepta namreč nikakor ne smemo dojemati le v povezavi s skupnimi viri, področji ali dobrinami, torej v pomenu tega, kar se najpogosteje dojema za skupno posest ali skupno »lastnino«. Skupno je namreč v prvi vrsti koncept, ki ga je nemogoče misliti brez družbenih odnosov, ki so njegov neizogiben del. Omenjen ožji oziroma zamejen pristop, ki je značilen predvsem za politično-ekonomski pogled na skupno, sicer lahko nudi enega izmed ključev za razumevanje raznolikosti skupnega in s kakšnimi tehnikami se ga v epohi bio-lingvističnega kapitalizma eksploatira, vendar bi ekskluzivno osredotočanje le na ta pomen reduciralo kompleksnost tako samega koncepta, kot tudi družbe, v kateri nastaja, s čimer bi lahko tvegali naturalizacijo nekaterih delov družbenega. Prvi del teksta je zato namenjen razjasnitvi mnoštva obrazov in pristopov, iz katerih je mogoče opazovati skupno, čemur šele v drugem delu in s pridržki sledi poizkus politično-ekonomske tipologizacije skupnega. V tem delu sta izpostavljeni predvsem dve »neotipljivi« obliki skupnega, ki postajata žrtvi novih procesov ograjevanja in privatizacije. V obeh primerih se lastnini same informacije, za katere je značilna nerivalska logika ter nizka subtraktivnost, s tem pa se ustvarja nove monopole nad znanjem, ki posredno vplivajo na delovanje celotne družbe. Ti procesi so omogočeni z zunaj-ekonomskimi posegi, predvsem prek uveljavljanja t.i. intelektualne lastnine, ki se na globalni ravni širi prek novih in rigidnih lastniških sistemov (npr. TRIPS, lastnikom pa omogoča omejevanje dostopa ter jim s tem potencialno prinaša ‘profit, ki postaja renta’. Avtor k skupnemu pristopa iz radikalne pozicije alternativne

  17. 血浆vWF:Ag、蛋白C活性在ALI/ARDS患者诊断和预后中的意义%Evaluation of Plasma vWF : Ag and Protein C Activity in the Diagnosis and Prognosis of Patients at Risk of ALI/ARDS

    Institute of Scientific and Technical Information of China (English)

    夏炎火; 林锡芳; 潘景业; 王丹; 李卓英; 杨梅

    2013-01-01

    Objective To evaluate the value and feasibility of plasma vWF: Ag and protein C activity in the diagnosis and prognosis in ALI/ARDS patients. Methods The clinical data of 49 ALI/ARDS patients and 21 non - ALI / ARDS patients was collected and evaluated with APACHE II score system and lung injury score(LIS). Furthermore, ALI/ARDS patients were divided into two groups by prognosis, etiology, and organ failure number ( nonpulmonary). Mortality of every group was collected. Plasma vWF:Ag and protein C activity of patients were detected and evaluated. The value of plasma vWF:Ag and protein C activity in diagnosis of ALI/ARDS was analyzed by receiver operator characteristic( ROC) curve. Results Compared with non - ALI/ARDS group, the mortality and LIS score of ALI/ARDS group were significantly increased, PaO2/FiO2 was significantly declined. Plasma vWF: Ag (104% -752% ) in ALI / ARDS group was higher (P = 0.026), but PC activity ( 14% -125%) was significantly lower (P =0. 002). In the ALI/ARDS patients, plasma vWF: Ag of dead group, infected group and 3: 2 organ failure group were significantly higher than their control group; while PC activity of the three groups were greatly lower than their control groups. ROC curve analysis showed that PC activity was better in prediction ALI/ARDS (AUC = 0.709,95% CI:0.588 -0. 811 ,P =0. 0016) ,and the sensitivity and specificity were respectively 77. 75% and 57. 14% when PC activity ≤83% ; but vWF: Ag was poor in prediction ALI/ARDS ( AUC =0. 584,95% CI:0. 460-0. 701, P=0.2426). Conclusion Elevated plasma vWF;Ag and declined PC activity are associated with an increased risk of death and worse prognosis in ALI/ARDS patients. The accuracy of plasma PC activity to predict ALI/ARDS was better, but it is a controversial conclusion in prediction ALI/ARDS by plasma vWF:Ag.%目的 探讨血浆血管性血友病因子抗原(vWF:Ag)、蛋白C(PC)活性在急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)患者早期诊断

  18. Prevalence of Oxyuriasis and its Influencing Factors in Elected Kindergartens in Ali Abad-e-Katoul, North of Iran

    Directory of Open Access Journals (Sweden)

    Morteza Mansourian

    2016-11-01

    Full Text Available Background: Enterobius vermicularis (formerly Oxyuriasis vermicularis, is a prevalent parasitic infection especially in preschool children worldwide. The present study aimed to explore the prevalence of Oxyuriasis and its influencing factors in kindergartens.Materials and Methods: A cross-sectional study was conducted on 175 children using multi-stage sampling method in Ali Abad-e-Katoul city- Iran in 2015 year. Data were collected using a three-part demographic questionnaire including personal characteristics, predisposing factor of infection, and clinical symptoms. Possibility of infection was tested by Graham method. Data were also analyzed using SPSS software (version 18. Significant level was also considered significant as

  19. Parallelization of the AliRoot event reconstruction by performing a semi- automatic source-code transformation

    CERN Document Server

    CERN. Geneva

    2012-01-01

    side bus or processor interconnections. Parallelism can only result in performance gain, if the memory usage is optimized, memory locality improved and the communication between threads is minimized. But the domain of concurrent programming has become a field for highly skilled experts, as the implementation of multithreading is difficult, error prone and labor intensive. A full re-implementation for parallel execution of existing offline frameworks, like AliRoot in ALICE, is thus unaffordable. An alternative method, is to use a semi-automatic source-to-source transformation for getting a simple parallel design, with almost no interference between threads. This reduces the need of rewriting the develop...

  20. The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.

    Science.gov (United States)

    Tian, Xiaochen; Devi-Rao, Gayathri; Golovanov, Alexander P; Sandri-Goldin, Rozanne M

    2013-07-01

    Herpes simplex virus 1 (HSV-1) protein ICP27 enables viral mRNA export by accessing the cellular mRNA export receptor TAP/NXF, which guides mRNA through the nuclear pore complex. ICP27 binds viral mRNAs and interacts with TAP/NXF, providing a link to the cellular mRNA export pathway. ICP27 also interacts with the mRNA export adaptor protein Aly/REF, which binds cellular mRNAs and also interacts with TAP/NXF. Studies using small interfering RNA (siRNA) knockdown indicated that Aly/REF is not required for cellular mRNA export, and similar knockdown studies during HSV-1 infection led us to conclude that Aly/REF may be dispensable for viral RNA export. Recently, the structural basis of the interaction of ICP27 with Aly/REF was elucidated at atomic resolution, and it was shown that three ICP27 residues, W105, R107, and L108, interface with the RNA recognition motif (RRM) domain of Aly/REF. Here, to determine the role the interaction of ICP27 and Aly/REF plays during infection, these residues were mutated to alanine, and a recombinant virus, WRL-A, was constructed. Virus production was reduced about 10-fold during WRL-A infection, and export of ICP27 protein and most viral mRNAs was less efficient. We conclude that interaction of ICP27 with Aly/REF contributes to efficient viral mRNA export.

  1. The effect of EVLW in fluid managemeent on sepsis ALI/ARDS%血管外肺水指数在脓毒症相关性ALI/ARDS患者液体管理中的意义

    Institute of Scientific and Technical Information of China (English)

    傅水桥; 崔巍; 骆晓倩

    2010-01-01

    目的 通过观察严重脓毒症/脓毒性休克患者血管外肺水指数(extravascular lung water index,EVLWI)与氧合指数(PaO2/FiO2)和胸腔内血容量指数(intrathoracic blood volume index,ITBVI)的相关性,探讨血管外肺水在脓毒症相关性急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)患者液体管理中的指导意义,为脓毒症相关性ALI/ARDS患者的液体管理提供新的临床策略.方法 选择2006年4月至2008年4月浙江大学医学院附属第二医院重症医学科符合严重脓毒症/脓毒性休克伴ALI/ARDS患者24例,应用PiCCO技术监测患者胸腔内血容量指数(ITBVI)和血管外肺水指数(EVLWI),用血气分析同时监测动脉血氧分压(PaO2),以PaO2/吸入氧浓度(FiO2)计算氧合指数.比较EVLWI与PaO2/FiO2和ITBVI与EVLWI之间的相关性.采用简单相关分析法进行统计学分析.结果 EVLWI与PaO2/FiO2呈明显负相关(r=-0.45,P<0.01).进一步以EVLWI=14 mL/kg进行分层分析,当EVLWI≤14 mL/kg时,两者无明显相关性(r=0.12,P=0.243);当EVLWI>14 mL/kg时,两者呈明显负相关(r=-0.47,P<0.01).这可以提示对严重脓毒症/脓毒性休克伴ALI/ARDS患者,EVLW不是影响氧合的唯一因素,当EVLWI>14 mL/kg时,可以通过降低EVLW来改善氧合,但更应综合考虑影响氧合指数的各种因素.ITBVI与EVLWI无明显相关性(r=0.02,P=0.84).进一步以ITBVI=1000 mL/m2进行分层分析,当ITBVI≤1000 mL/m2时,两者无明显相关性(r=0.13,P=0.17);当ITBVI>1000 mL/m2时,两者呈明显正相关(r=0.40,P<0.01).这提示我们对于脓毒症相关性ALI/ARDS,当ITBVI>1000mL/m2时,可以通过降低ITBV来降低EVLW,但对于肺毛细血管通透性增高症引起的EVLW,不能通过降低ITBV来降低.结论 EVLW在脓毒症相关性ALI/ARDS的液体管理中具有重要指导意义.%Objective The management of fluid infusion is crucial in severe sepsis/septic shock patients.The correlation of extravascular lung water index(EVLWI) versus

  2. Frequency of Meningitis in Children Presenting with Febrile Seizures at Ali- Asghar Children’s Hospital

    Directory of Open Access Journals (Sweden)

    Azita TAVASOLI

    2014-12-01

    Full Text Available How to Cite This Article: Tavasoli A, Afsharkhas L, Edraki A. Frequency of Meningitis in Children Presenting with Febrile Seizure in Ali-Asghar Children’s Hospital. Iran J Child Neurol. 2014 Autumn; 8(4:51-56.AbstractObjectiveFebrile seizures (FS are the most common type of childhood seizures, affecting 2–5% of children. As the seizure may be the sole presentation of bacterial meningitis in febrile infants, it is mandatory to exclude underlying meningitis in children presenting with fever and seizure. To determine the frequency of meningitis in children with FS and related risk factors, the present study was conducted at Ali-Asghar Children’s Hospital.Materials & MethodsThe records of children aged from 1-month–6 years of age with fever and seizure admitted to the hospital from October 2000–2010 were studied. The charts of patients who had undergone a lumbar puncture were studied and cases of meningitis were selected. The related data was collected and analyzed with SPSS version 16.ResultsA total of 681 patients with FS were known from which 422 (62% lumbar punctures (LP were done. Meningitis (bacterial or aseptic was identified in 19 cases (4.5%, 95% CI 2.9–6.9 by Wilson- Score internal and bacterial meningitis in 7 (1.65%, 95% CI 0.8–3.3. None of the patients with bacterial meningitis had meningeal irritation signs. Complex FS, first attack of FS, and impaired consciousness were more common in patients with meningitis when compared to non- meningitis patients.ConclusionMeningitis is more common in patients less than 18 months presenting with FS; however, complex features of seizures, first attack of FS, or impaired consciousness seem significant risk factors for meningitis in these children and an LP should be considered in this situation. ReferencesKimia A, Ben-Joseph EP, Rudleo T, et al. Yield of lumbar puncture among children who present with their first complex febrile seizure. Pediatrics.2010; 126: 62

  3. Caractérisation de jonctions ultra-minces réalisées par dopage laser

    Science.gov (United States)

    Kerrien, G.; Sarnet, T.; Débarre, D.; Hernandez, M.; Zahorski, D.; Venturini, J.; Laviron, C.; Semeria, M. N.; Boulmer, J.

    2003-06-01

    Cette étude concerne les techniques de recuit laser (LTP) et de dopage laser direct (GILD) de jonctions ultra-minces, nécessaires à la fabrication des composants microélectroniques du futur (générations CMOS sub 0,1 μm). Des jonctions de 20 à 80 nm sont réalisées à l'aide d'un laser à excimères. Le procédé est suivi en temps réel grâce à l'analyse de la réflectivité transitoire à 675 nm. L'évolution de l'activation des dopants est ensuite caractérisée par spectroscopie IR (FTIR). Les résultats obtenus permettent de caractériser les jonctions en termes d'épaisseur dopées, concentration et résistivité. Une comparaison avec des caractérisations classiques (mesures électriques de résistivité, profils SIMS) permet de valider ces mesures et de mettre en évidence l'intérêt des techniques optiques pour la caractérisation in-situ et ex-situ des couches minces dopées réalisées par laser.

  4. [Pathology of adaptation according to Sami-Ali and index of conformity to the Rorschach test in ulcerative rectocolitis].

    Science.gov (United States)

    Porcelli, P; Zaka, S; Tarantino, S; Sisto, G

    1992-01-01

    According to Sami-Ali's theoretical model the psychosomatic personality is characterised by an adaptation pathology whose main elements are the repression of imaginative thought and conformity to socio-cultural standards. This study examines adaptation pathology using the Rorschach test. The Authors have formulated a conformity index by relating kinestheses (M) and banal perceptions (BAN). The study was carried out on a sample of 41 patients suffering from ulcerous rectocolitis comprising 24 males and 17 women with a mean age of 32 years. As expected in the hypothesis 97.6% of the sample showed M values below the norm, and 68.3% had Ban values higher than normal, whereas the conformity index was positive and tendentially positive in 65.9% of cases. These findings confirm Sami-Ali's theory. Subjects with ulcerous rectocolitis form part of the adaptation pathology which characterised the psychosomatic personality, with an inverse proportionality between imaginative activity (kinesthesia below normal) and conformism (banal perceptions above the norm).

  5. The Effects of Physical Education Course on Mental Health of Students in Bu-Ali Sina University, Hamedan-Iran

    Directory of Open Access Journals (Sweden)

    Sajad Moemeni Piri

    2015-03-01

    Full Text Available IntroductionMental disorders are a major cause of morbidity and disability in the worldand can reduce the success and academic achievement. Experts believe that exercise can be used as a means to achieve favorable mental status. The aim of this study was to investigate the effect of physical education course (I on mental health of Bu-Ali Sina University students, Hamadan.MethodologyIn this descriptive study, 108 students of Bu-Ali Sina University, were randomly selected as research sample. Data collection tool was the 28-item standard questionnaire of Mental Health of Goldberg (GHQ-28 with 0. 89 reliability. To determine the suspected cases of mental disorders, cutoff point 23 has been used. Data were analyzed using descriptive and inferential statistics (Pair t-tests at the significance level 0.05.ResultsThe findings showed that the average pretest score of students` mental health was 21.86 ± 8.96 and the average post-test score was 22.55 ± 10.83. 40.7 percent of participants were suspected to have mental disorders before participation in physical education classes (score above 23 and decreased to 37% after the end of the semester, the dependent t-test results showed no significant difference between students` mental health before and after the general physical education (p> 0.05. The post-test results showed that depressive symptoms were significantly increased (p>0.05; 2.81 ± 5.64.Conclusion

  6. Equations of state of anhydrous AlF3 and AlI3: Modeling of extreme condition halide chemistry.

    Science.gov (United States)

    Stavrou, Elissaios; Zaug, Joseph M; Bastea, Sorin; Crowhurst, Jonathan C; Goncharov, Alexander F; Radousky, Harry B; Armstrong, Michael R; Roberts, Sarah K; Plaue, Jonathan W

    2015-06-07

    Pressure dependent angle-dispersive x-ray powder diffraction measurements of alpha-phase aluminum trifluoride (α-AlF3) and separately, aluminum triiodide (AlI3) were conducted using a diamond-anvil cell. Results at 295 K extend to 50 GPa. The equations of state of AlF3 and AlI3 were determined through refinements of collected x-ray diffraction patterns. The respective bulk moduli and corresponding pressure derivatives are reported for multiple orders of the Birch-Murnaghan (B-M), finite-strain (F-f), and higher pressure finite-strain (G-g) EOS analysis models. Aluminum trifluoride exhibits an apparent isostructural phase transition at approximately 12 GPa. Aluminum triiodide also undergoes a second-order atomic rearrangement: applied stress transformed a monoclinically distorted face centered cubic (fcc) structure into a standard fcc structural arrangement of iodine atoms. Results from semi-empirical thermochemical computations of energetic materials formulated with fluorine containing reactants were obtained with the aim of predicting the yield of halogenated products.

  7. Agama Sebagai Kesadaran Ideologis: Refleksi Perubahan Sosial Ali Syari’ati

    Directory of Open Access Journals (Sweden)

    Imam Bonjol Jauhari

    2016-06-01

    Full Text Available Abstract: In the context of social change, the thought of Ali Syar'ati, if seen from the perspective of its frameworks and methods,is different from the thought of other Islamic movements.On the one hand, Shari'ati’s thought opposes the Iranian authority, Shah Pahlavi, but on the other hand, it is totally different from the traditional Iranian anti-change cleric, and it is also in contrast to the radical Islamic movements that do political rebellion against the ruler.Shari'atiput up political resistance through revolutionary ideas influencing public opinion to understand Islam as a doctrine which has an emancipatory interest, that is, the belief of Islam as a school of thought and action in the fight against social and economic injustice, despotic ruler, and the fetters of culture. Efforts to comprehend Islamic meanings in modern and contextual Islamic thought presents two patterns of social changes; first is the pattern of moderatemovement and second is extreme one. The formerleads more specifically to how to implement Islamic values in the national way of life, and   sense of nationalitywithout being trapped inreligious symbols and labels, while the latter leads totheimplementation of Islamic values and symbolismand labeling whichare both considered to be important. So the former tends to take more substantive values of Islam that is essentially concerned with the purpose of realization of the ideals of Islam, while the latter tends to the enactment of Islamic lawin all aspects of community life.  الملخص: في سياق التغيير الاجتماعي، يعتقد أن فكرة علي شريعتي لها إطار وأساليب تختلف عن أساليب رواد الفكر والحركات الإسلامية الأخرى. من ناحية ،أن شريعتي يكافح ضد سلطة مستبدة في إيران، شاه بهلوي. ومن ناحية أخرى، كان مختلفا تماما عن علماء الدين

  8. Etnocentrizmo ir prekės kilmės šalies įtaka vartotojų ketinimui pirkti

    OpenAIRE

    Keibienė, Asta

    2014-01-01

    Etnocentrizmas ir prekės kilmės šalis – du tarpusavyje glaudžiai susiję veiksniai, vartotojų ketinimą pirkti veikiantys tiesiogiai. Etnocentrizmas ir jo lygis atskleidžia, kaip vartotojai lygina užsienio kilmės produktus su savo šalies produktais, o prekės kilmės šalies efektas galinti pasitarnauti kaip tam tikrų prekės savybių rodiklis. Ketinimą pirkti mėgstamas prekes dažnai lemia tokios savybės kaip kaina, prekės ženklas ar kokybė. Vartotojams didelę įtaką daro žinojimas, kad viena ar kita...

  9. Endocytosis of the Aspartic Acid/Glutamic Acid Transporter Dip5 Is Triggered by Substrate-Dependent Recruitment of the Rsp5 Ubiquitin Ligase via the Arrestin-Like Protein Aly2 ▿

    Science.gov (United States)

    Hatakeyama, Riko; Kamiya, Masao; Takahara, Terunao; Maeda, Tatsuya

    2010-01-01

    Endocytosis of nutrient transporters is stimulated under various conditions, such as elevated nutrient availability. In Saccharomyces cerevisiae, endocytosis is triggered by ubiquitination of transporters catalyzed by the E3 ubiquitin ligase Rsp5. However, how the ubiquitination is accelerated under certain conditions remains obscure. Here we demonstrate that closely related proteins Aly2/Art3 and Aly1/Art6, which are poorly characterized members of the arrestin-like protein family, mediate endocytosis of the aspartic acid/glutamic acid transporter Dip5. In aly2Δ cells, Dip5 is stabilized at the plasma membrane and is not endocytosed efficiently. Efficient ubiquitination of Dip5 is dependent on Aly2. aly1Δ cells also show deficiency in Dip5 endocytosis, although less remarkably than aly2Δ cells. Aly2 physically interacts in vivo with Rsp5 at its PY motif and also with Dip5, thus serving as an adaptor linking Rsp5 with Dip5 to achieve Dip5 ubiquitination. Importantly, the interaction between Aly2 and Dip5 is accelerated in response to elevated aspartic acid availability. This result indicates that the regulation of Dip5 endocytosis is accomplished by dynamic recruitment of Rsp5 via Aly2. PMID:20956561

  10. Outcome prediction in pneumonia induced ALI/ARDS by clinical features and peptide patterns of BALF determined by mass spectrometry.

    Directory of Open Access Journals (Sweden)

    Jochen Frenzel

    Full Text Available BACKGROUND: Peptide patterns of bronchoalveolar lavage fluid (BALF were assumed to reflect the complex pathology of acute lung injury (ALI/acute respiratory distress syndrome (ARDS better than clinical and inflammatory parameters and may be superior for outcome prediction. METHODOLOGY/PRINCIPAL FINDINGS: A training group of patients suffering from ALI/ARDS was compiled from equal numbers of survivors and nonsurvivors. Clinical history, ventilation parameters, Murray's lung injury severity score (Murray's LISS and interleukins in BALF were gathered. In addition, samples of bronchoalveolar lavage fluid were analyzed by means of hydrophobic chromatography and MALDI-ToF mass spectrometry (MALDI-ToF MS. Receiver operating characteristic (ROC analysis for each clinical and cytokine parameter revealed interleukin-6>interleukin-8>diabetes mellitus>Murray's LISS as the best outcome predictors. Outcome predicted on the basis of BALF levels of interleukin-6 resulted in 79.4% accuracy, 82.7% sensitivity and 76.1% specificity (area under the ROC curve, AUC, 0.853. Both clinical parameters and cytokines as well as peptide patterns determined by MALDI-ToF MS were analyzed by classification and regression tree (CART analysis and support vector machine (SVM algorithms. CART analysis including Murray's LISS, interleukin-6 and interleukin-8 in combination was correct in 78.0%. MALDI-ToF MS of BALF peptides did not reveal a single identifiable biomarker for ARDS. However, classification of patients was successfully achieved based on the entire peptide pattern analyzed using SVM. This method resulted in 90% accuracy, 93.3% sensitivity and 86.7% specificity following a 10-fold cross validation (AUC = 0.953. Subsequent validation of the optimized SVM algorithm with a test group of patients with unknown prognosis yielded 87.5% accuracy, 83.3% sensitivity and 90.0% specificity. CONCLUSIONS/SIGNIFICANCE: MALDI-ToF MS peptide patterns of BALF, evaluated by appropriate

  11. Elektroninės vietovės marketingo sistemos pritaikymas suinteresuotųjų šalių naudojimo poreikiams

    OpenAIRE

    Stočkūnas, Andrius

    2016-01-01

    Baigiamojo darbo tikslas parengti elektroninės vietovės marketingo sistemos pritaikymo suinteresuotųjų šalių naudojimo poreikiams modelį. Magistro baigiamąjį darbą sudaro trys dalys - teorinė, analitinė ir projektinė. Teorinėje darbo dalyje analizuojama elektroninės vietovės marketingo sistemos samprata ir panaudojimo funkcijos, suinteresuotosios sistemos šalys ir jų informaciniai ir naudojimosi sistema poreikiai - sudaromas teorinis pagrindas tyrimui atlikti. Analitinėje baigiamojo darbo dal...

  12. Regions of Different Confinement in Low-Dimensional AlyInxGa1−x−yN Quantum Structures

    Directory of Open Access Journals (Sweden)

    A. Gröning

    2007-01-01

    Full Text Available The optical properties of metal-organic vapor phase epitaxy grown AlyInxGa1−x−yN quantum dot structures have been studied by time-resolved photoluminescence experiments. We investigated the recombination dynamics of the photo-exited carriers in dependence of the growth parameters such as aluminium flow and the duration of the growth interruption after the dot deposition. Our results confirm the presence of localized states, where the degree of localization is strongly dependent on the growth conditions. To describe this behavior, we propose a band structure with coupled potentials for these nanostructures. Finally, we demonstrate state filling to prove the zero-dimensional character of the strongly localized states in our quaternary quantum dots.

  13. Plasticité du droit constitutionnel et dynamique de l’autoritarisme dans la Tunisie de Ben Ali

    Directory of Open Access Journals (Sweden)

    Éric Gobe

    2012-02-01

    Full Text Available Le droit des institutions politiques dans la Tunisie de Ben Ali apparaît particulièrement plastique et instable car ce sont les échéances politiques liées à la pérennisation du régime autoritaire qui dictent le rythme et la nature des changements institutionnels. Ce droit est conçu de façon à rendre impensable l’éventualité d’une alternance au sommet de l’État tout en permettant aux pouvoirs publics tunisiens de tenir un discours sur la résolution de la Tunisie à approfondir son engagement démocratique. Les récents textes constitutionnels et législatifs organisant la vie politique concourent, dans le même temps à limiter formellement les pratiques autoritaires tout en les autorisant si nécessaire.

  14. New insights into the structure of Om Ali-Thelepte basin, central Tunisia, inferred from gravity data: Hydrogeological implications

    Science.gov (United States)

    Harchi, Mongi; Gabtni, Hakim; El Mejri, Hatem; Dassi, Lassaad; Mammou, Abdallah Ben

    2016-08-01

    This work presents new results from gravity data analyses and interpretation within the Om Ali-Thelepte (OAT) basin, central Tunisia. It focuses on the hydrogeological implication, using several qualitative and quantitative techniques such as horizontal gradient, upward continuation and Euler deconvolution on boreholes log data, seismic reflection data and electrical conductivity measurements. The structures highlighted using the filtering techniques suggest that the Miocene aquifer of OAT basin is cut by four major fault systems that trend E-W, NE-SW, NW-SE and NNE-SSW. In addition, a NW-SE gravity model established shows the geometry of the Miocene sandstone reservoir and the Upper Cretaceous limestone rocks. Moreover, the superimposition of the electrical conductivity and the structural maps indicates that the low conductivity values of sampled water from boreholes are located around main faults.

  15. Bensaâd Ali (dir., L’eau et ses enjeux au Sahara, Iremam, Karthala, 2011, 242 p.

    Directory of Open Access Journals (Sweden)

    Jean-Louis Marçot

    2011-11-01

    Full Text Available Je dirai en premier ma déception. Comme le suggère Ali Bensaâd à l’entrée du livre qu’il a dirigé, l’enjeu de l’eau au Sahara n’est ni plus ni moins que la conservation de la vie dans ce milieu qui lui est particulièrement hostile - la vie sous tous ses aspects. Or cet enjeu « vital » a été négligé au profit d’une approche micro-géographique. C’est pourtant par cette entrée que le travail collectif aurait pu légitimement intéresser un vaste public. Comment l’eau existe-t-elle à l’état naturel...

  16. Optimisation du profil de dopage d'un MESFET réalisé par implantation ionique

    OpenAIRE

    Cazaux, J.L.; Graffeuil, Jacques; Pavlidis, D.

    1986-01-01

    On analyse l'interdépendance entre les performances d'un transistor à effet de champ en arséniure de gallium et son profil de dopage réalisé par implantation ionique. On étudie en particulier l'influence des conditions d'implantation (énergie et dose implantées) ainsi que celle du creusement de grille (« recess ») préalablement à la réalisation de la barrière Schottky. Les résùltats théoriques ont été obtenus à l'aide d'un simulateur permettant d'accéder aux propriétés statiques et dynamiques...

  17. Changes of plasma renin activity and angiotensin Ⅱ level in and its sig-nificance%血浆PRA、AngⅡ在ALI/ARDS患者中的变化和意义

    Institute of Scientific and Technical Information of China (English)

    夏炎火; 郑小蕾; 王丹; 余方友; 林锡芳; 潘景业

    2014-01-01

    目的:探讨PRA、AngⅡ在ALI/ARDS患者中的变化和意义。方法测定ALI/ARDS和非ALI/ARDS患者血浆PRA和AngⅡ浓度,进行APACHEⅡ评分和LIS评分,计算病死率,进一步将患者按预后分组,进行比较和相关分析,利用ROC曲线评价PRA和AngⅡ的诊断分辨度。结果与非ALI/ARDS组相比,ALI/ARDS组血浆PRA和AngⅡ浓度明显增高(P<0.05),死亡组血浆PRA和AngⅡ浓度高于存活组(P <0.05)。 PRA、AngⅡ与APACHEⅡ评分、LIS、乳酸(LAC)间均呈明显正相关。 PRA在预测ALI/ARDS方面有显著意义(AUC=0.705,P=0.001),AngⅡ对预测ALI/ARDS也有显著意义(AUC=0.672, P=0.007)。在预测ALI/ARDS方面,PRA、AngⅡ与LIS相比无明显差异(P=0.923,P=0.713)。结论 ALI/ARDS患者血浆PRA和AngⅡ水平明显升高,两者在预测ALI/ARDS和判断其预后方面均有重要意义,而AngⅡ在预测ALI/ARDS中的特异度较高。%Objective To investigate the clinical significance and levels of plasma renin activity (PRA), Angiotensin (Ang) Ⅱ in ALI / ARDS patients. Methods The levels of PRA and AngⅡ, APACHE Ⅱ score, lung injury score(LIS), and mortality were analyzed in ALI/ARDS patients and non-ALI/ARDS group. After the patients were grouped accord-ing to prognosis, correlation analysis and ROC curve to evaluate diagnostic efficacy of PRA and AngⅡ were performed. Results Compared with non- ALI/ARDS group, the levels of PRA and AngⅡ were significantly increased in ALI/ARDS (P<0.05). In the death group, the levels of PRA and AngⅡwere higher than that of the survival group (P<0.05). It was significant positive correlation between APACHEⅡ score,LIS,lactic acid (LAC) and PRA, so as AngⅡ. In pre-dicting ALI/ARDS, PRA was significant (AUC=0.705, P=0.001), so as AngⅡ(AUC=0.672, P =0.007). In predict-ing ALI/ARDS, there was no significant difference between PRA and LIS (P=0.923), and also between AngⅡ and LIS (P = 0.713). Conclusion

  18. Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication.

    Science.gov (United States)

    Li, Da-Jiang; Verma, Dinesh; Swaminathan, Sankar

    2012-09-01

    Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is expressed early during lytic KSHV replication, enhances expression of many KSHV genes, and is essential for virus production. ORF57 is a member of a family of proteins conserved among all human and many animal herpesviruses that are multifunctional regulators of gene expression and act posttranscriptionally to increase accumulation of their target mRNAs. The mechanism of ORF57 action is complex and may involve effects on mRNA transcription, stability, and export. ORF57 directly binds to REF/Aly, a cellular RNA-binding protein component of the TREX complex that mediates RNA transcription and export. We analyzed the effects of an ORF57 mutation known to abrogate REF/Aly binding and demonstrate that the REF-binding mutant is impaired in activation of viral mRNAs and noncoding RNAs confined to the nucleus. Although the inability to bind REF leads to decreased ORF57 activity in enhancing gene expression, there is no demonstrable effect on nuclear export of viral mRNA or the ability of ORF57 to support KSHV replication and virus production. These data indicate that REF/Aly-ORF57 interaction is not essential for KSHV lytic replication but may contribute to target RNA stability independent of effects on RNA export, suggesting a novel role for REF/Aly in viral RNA metabolism.

  19. Muusikamaailm : Ozawa festival Matsumotos. Pidustused Utrechtis ülehomseni. Philip Glassi uusteos Salzburgis. Alexandre Lagoya surnud. Frangiz Ali-Zade asutamine Luzernis. Wolfgang Wagner 80 / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    1999-01-01

    H.Saito mälestusfestivalist "Saito Kinen" 29.08-12.09 Jaapanis. Utrechti varajase muusika pidustustest 27.08-5.09. P.Glassi teose "Requiem, Bardo and Nimanakaya" maailmaesiettekandest Salzburgi suvefestivalil 28.08. A. Lagoya elust ja tegevusest. Luzerni festivali resideerivaks heliloojaks oli F.Ali-Zade. W. Wagneri tegevusest impressaariona

  20. Examination of the "Theory of Guidance" in the View of 'Ali Ibn Abi Talib (A): An Exploration into the Nahj Al-Balaghah

    Science.gov (United States)

    Rostami-Nasab, Abas Ali; Tajedini, Oranus; Sadatmoosavi, Ali

    2016-01-01

    This study examines the "Theory of Guidance" according to 'Ali ibn Abi Talib (a). This theory is based on three divine covenants or fundamentals in guidance including the divine Prophet, the divine Book, and the divine human nature ("fitrat"). Research in this regard seems essential because this theory has not been previously…

  1. Noise disturbance caused by outdoor activities--a simulated-environment study for Ali Sami Yen Stadium, İstanbul.

    Science.gov (United States)

    Dal, Zeynep; Akdağ, Neşe Yüğrük

    2011-03-01

    Negative effects of noise on individuals, the inevitable result of urbanization, have become a significant urban problem in our day. Introduction of an approach to the noise problem on an urban-planning scale lightens the burden of measures required to be taken against noise at the stages of regional and developmental planning. Stadiums, which should be also evaluated from the point of noise problem when planning decisions are made on the urban planning scale, may cause very serious problems differing depending on the region they are located in. In this article, various dimensions of the noise problem caused by stadiums have been exemplified by making an assessment on Ali Sami Yen football stadium located in Mecidiyeköy district which is among important residential and commercial centres of İstanbul or Turkey. When the simulation results obtained for ordinary days and match days are evaluated, it has been found out that the people living in the area are exposed to noise levels substantially exceeding the acceptable values. Results of the survey conducted in the area have clearly revealed the existence of noise problem, too.

  2. Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.

    Science.gov (United States)

    Hung, Ming-Lung; Hautbergue, Guillaume M; Snijders, Ambrosius P L; Dickman, Mark J; Wilson, Stuart A

    2010-06-01

    The REF/ALY mRNA export adaptor binds TAP/NXF1 via an arginine-rich region, which overlaps with its RNA-binding domain. When TAP binds a REF:RNA complex, it triggers transfer of the RNA from REF to TAP. Here, we have examined the effects of arginine methylation on the activities of the REF protein in mRNA export. We have mapped the arginine methylation sites of REF using mass spectrometry and find that several arginines within the TAP and RNA binding domains are methylated in vivo. However, arginine methylation has no effect on the REF:TAP interaction. Instead, arginine methylation reduces the RNA-binding activity of REF in vitro and in vivo. The reduced RNA-binding activity of REF in its methylated state is essential for efficient displacement of RNA from REF by TAP in vivo. Therefore, arginine methylation fine-tunes the RNA-binding activity of REF such that the RNA-protein interaction can be readily disrupted by export factors further down the pathway.

  3. Report of thirty one admissions due to adverse drug reactions inBo-Ali Sina hospital, Sari, Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Rafati

    2009-01-01

    Full Text Available , (Received 16 May, 2009 ; Accepted 8 July, 2009AbstractBackground and purpose: Adverse drug reactions (ADRs are one of the leading causes of morbidity and mortality, worldwide. Mortality rate due to ADRs are ahead of pulmonary disease, AIDS, pneumonia and automobile accidents. This study evaluated the admission rates in a University teaching hospital related to ADRs.Materials and methods: During this retrospective study between 2001 and 2007, all patients admitted due to adverse drug reaction in Sari Bo-Ali Sina Hospital were evaluated.Results: In these years, 31 patients out of 71,680 were admitted, due to ADRs. Most common ADRs were skin reaction (74% and fever (22%. Phenobarbital and penicillin were the most common drugs causing ADRs.Conclusion: Only 0.04% of hospital admissions were drug related, while reported admission due to ADRs in other countries were 2.4 to 6.2%. It appears that less drug-depended hospital admissions in Iran rational drug administration, but are due to lack of enough detection, records and reporting procedures.J Mazand Univ Med Sci 2009; 19(71: 67-70 (Persian.

  4. Insight into the reaction mechanisms for oxidative addition of strong σ bonds to an Al(i) center.

    Science.gov (United States)

    Zhang, Xiangfei; Cao, Zexing

    2016-06-21

    The oxidation addition of a series of σ H-X bonds (X = H, B, C, Si, N, P, and O) to a single Al(i) supported by a (NacNac)(-) bidentate ligand ((NacNac)(-) = [ArNC(Me)CHC(Me)NAr](-) and Ar = 2,6-(i)Pr2C6H3) has been explored through extensive DFT calculations. The presented results show that activation and addition of these σ bonds follow various reaction mechanisms, in which hydride transfer, proton transfer, and Al-X bond coupling steps are involved. The predicted free energy barriers for these oxidative additions range from 8 to 32 kcal mol(-1), and all the reactions are remarkably favorable thermodynamically. However, sterically hindered ligands, for most reactants, make the formation of the initial reactant complex difficult and may reduce the efficiency of the reaction. Calculations reveal a strong dependence of the reaction mechanism and low-energy channel on the bonding features of X-H and the local structural environments.

  5. A little known astronomer in the late Islamic period. A study of Qasim ali al-Qayini's manuscripts

    CERN Document Server

    Akbari, Marjan

    2012-01-01

    It is widely believed that the advance of science in the Islamic world after the mid-fifteenth century A.D. suffered a decline. For the purpose of examining this belief, a manuscript by Qasim ali al-Qayini (ca. A.D.1685) was chosen based on previous works which considered it a valuable source on the history of optics that had not been studied before. After studying his major optical manuscript, titled Manazir wa Maraya, it was found very interesting that the majority of al-Qayini's propositions relating to natural phenomena were not merely geometrical definitions, but that the proofs related to astronomy. As an example, in one case, which had not been explained in previous astronomical and optical manuscripts, al-Qayini tried, despite lacking a vigorous proof, to show how a special point in a room could be lit up by sunlight throughout the year. His particular interest in astronomy led us to a general study of his other works, and it is worth noting that out of the nineteen works that have been attributed to ...

  6. Patandžali jogas un Kundalīni jogas sintēze Tantra jogas doktrīnā

    OpenAIRE

    Hvoraks, Antons

    2007-01-01

    Antons Hvoraks, Patandžali Jogas un Kundalīni Jogas sintēze Tantra Jogas doktrīnā, Rīga, 2007. Darba tēze: „Tantra-joga” skolas filozofija ir Patandžali jogas un Kundalīni jogas sintēze. Darbs sastāv no ievada, trim nodaļām, kuras ir sadalītas 20 apakšnodaļās, un no noslēguma daļas ar secinājumiem. Pirmajā nodaļā tiek aplūkoti klasiskās jogas uzskati par Visumu un cilvēku, par iespējām sasniegt atbrīvošanu un jogas kustības lielo izplatību. Otrajā nodaļā aprakstīti tantrisma uzs...

  7. Stress conditions promote yeast Gap1 permease ubiquitylation and down-regulation via the arrestin-like Bul and Aly proteins.

    Science.gov (United States)

    Crapeau, Myriam; Merhi, Ahmad; André, Bruno

    2014-08-01

    Gap1, the yeast general amino acid permease, is a convenient model for studying how the intracellular traffic of membrane transporters is regulated. Present at the plasma membrane under poor nitrogen supply conditions, it undergoes ubiquitylation, endocytosis, and degradation upon activation of the TORC1 kinase complex in response to an increase in internal amino acids. This down-regulation is stimulated by TORC1-dependent phosphoinhibition of the Npr1 kinase, resulting in activation by dephosphorylation of the arrestin-like Bul1 and Bul2 adaptors recruiting the Rsp5 ubiquitin ligase to Gap1. We report here that Gap1 is also down-regulated when cells are treated with the TORC1 inhibitor rapamycin or subjected to various stresses and that a lack of the Tco89 subunit of TORC1 causes constitutive Gap1 down-regulation. Both the Bul1 and Bul2 and the Aly1 and Aly2 arrestin-like adaptors of Rsp5 promote this down-regulation without undergoing dephosphorylation. Furthermore, they act via the C-terminal regions of Gap1 not involved in ubiquitylation in response to internal amino acids, whereas a Gap1 mutant altered in the N-terminal tail and resistant to ubiquitylation by internal amino acids is efficiently down-regulated under stress via the Bul and Aly adaptors. Although the Bul proteins mediate Gap1 ubiquitylation of two possible lysines, Lys-9 and Lys-16, the Aly proteins promote ubiquitylation of the Lys-16 residue only. This stress-induced pathway of Gap1 down-regulation targets other permeases as well, and it likely allows cells facing adverse conditions to retrieve amino acids from permease degradation.

  8. Logistic Service Development of E-commerce : A case study of AliExpress - an online international trade platform in China

    OpenAIRE

    Gong, Wei; Kan, Xuan

    2013-01-01

    Background: as a convergence of business activities and information technology, e-commerce has brought massive changes to the supply chain management. Today, many e-commerce companies choose to cooperate with third party logistic service providers to perform or improve their logistic services. Meanwhile, those e-commerce companies con-sistently affect the operational processes of their logistic service providers. This thesis fo-cuses on the case of AliExpress, which is an e-commerce company t...

  9. First-principles study of zinc-blende BxAlyIn1-x-yN quaternary alloy: Alchemical mixing approximation approach

    Science.gov (United States)

    Bamgbose, M. K.; Adebambo, P. O.; Badmus, B. S.; Dare, E. O.; Akinlami, J. O.; Adebayo, G. A.

    2016-08-01

    Detailed first-principle calculations of properties in zinc blende quaternary alloy BxAlyIn1-x-yN at various concentrations are investigated using density functional theory (DFT) within virtual crystal approximation (VCA) implemented in alchemical mixing approximation. The calculated bandgaps show direct transitions at Γ-Γ and indirect transitions at Γ-X, which are opened by increasing boron concentration. The density of state (DOS) revealed upper valence band (VB1) domination by p-states atoms, while s-states dominate the lower valence band (VB2); also, the DOS shows the contribution of d-states to the conduction band. The first critical point in the dielectric constant ranges between 0.07-4.47 eV and is due to the first threshold optical transitions in the energy bandgap. Calculated static dielectric function (DF) 𝜖1(0) is between 5.15 and 10.35, an indication that small energy bandgaps yield large static DFs. The present results indicate ZB-BxAlyIn1-x-yN alloys are suitable candidates of deep ultraviolet light emitting diodes (LEDs), laser diodes (LDs) and modern solar cell since the concentrations x and y make the bandgap and lattice constant of ZB-BxAlyIn1-x-yN quaternary alloys tunable to desirable values.

  10. Evaluation of Myocardial Performance Index(Mpi in Beta Thalassemia Major Patients at the Ali Asghar Hospital , Zahedan , Iran

    Directory of Open Access Journals (Sweden)

    R Sohrevardi

    2004-04-01

    Full Text Available Introduction : Patients with major thalassemia need recurrent transfusions and if not treated are at risk of heart dysfunction. Heart tissue could be abnormal in patients who use desferral continously due to iron deposits , fibrosis , hypertrophy and side effects of chronic anemia. Cardiac involvement is the main cause of morbidity and mortality in major thalassemics, so we decided to improve early diagnosis of cardiac involvement by measuring myocardial performance index( MPI . Method & Materials : This case-control study was performed from April 2003 to December 2003 at the Ali-Asghar pediatrics hospital, Zahedan, Iran. MPI of both ventricles was measured by Doppler echocardiography in 48 patients with major thalassemia aged between 10-18 years and compared with 48 age , sex-matched controls. Patients had no abnormality in physical examination , chest x-ray and ECG and echocardiography did not show heart failure. Hemoglobin and serum ferritin levels was measured in all patients before echocardiography. Results: Mean age of patients was 12.3±2.4 years and that in the control group was 12.7±2years . Right ventricle isovolumetric relaxation time (RVIRT (107 ± 14 vs 94 ±14 , p0.05 and LVICT (31 ± 13 vs 21 ± 15 , p0.05 in the two groups. Finally, RVMPI (0.59 ± 0.12 Vs 0.46 ± 0.12 , p<0.001 was increased in 87% of patients and LVMPI (0.49 ± 0.12 Vs 0.41± 0.09 , p0.05. Conclusion: This study showed that RVMPI and LVMPI increase in major thalassemia patients that indicates systolic and diastolic dysfunction and RVMPI increases more than LVMPI. On the other hand, MPI has a direct correlation with serum ferritin . On the basis of this study ,we suggest MPI measurement in serial echocardiography in asymptomatic major thalassemia patients.

  11. Designing Learning Materials within the Framework of the ALIS-T Project: Story Telling Activities for Hearing Impaired Individuals

    Directory of Open Access Journals (Sweden)

    Yasemin Karal

    2014-04-01

    Full Text Available The present study aims to examine the usefulness of 47 stories which were developed as learning materials within the scope of the ALIS-T (Alternative Communication System – Design Project. This project aims to develop a graphical symbolic system which is relevant to Turkish social and cultural systems of understanding. In the study, stories were developed (generated by a Turkish Language and Literature academic taking the objectives of primary 1st year life science, Turkish, and mathematics curricula into account. Stories, which consist of a setting, characters, and plot were developed. The stories were presented to 5 teachers who teach to hearing impaired students in order to check the appropriateness of each. Those teachers’ views were taken into account about the positive/negative effects of stories in the learning and teaching activities. On the other hand, all stories were elaborated by teachers in terms of whether they met the objectives of curriculum and were useful in developing the literacy skills of hearing impaired pupils. Teachers were asked to do any alterations or corrections needed to make stories compatible with curriculum objectives. Obtained data were analyzed descriptively. All participants stated that each of the stories were beneficial and usable for teaching and learning activities. They emphasized that sentences should be short, clear, and comprehendible and found that stories which were too long should be corrected. On the basis of teachers’ feed-back, 39 stories were re-designed and corrected. 8 stories which were found to be unsuitable were excluded from the study

  12. AliPDU Upgrade

    CERN Document Server

    Mhlanga, Sibaliso

    2014-01-01

    A power distribution unit (PDU) is a device used in data centres to distribute AC power to multiple servers and other equipment. Power distribution units (PDUs) can be managed remotely via the Web browser or other management console, causing outlets to be turned on and off at prescribed times and in a proper sequence for shutting down and powering up equipment. The task in this project was to create as many PDUs on one click and customize them.

  13. Summer students and professor from the United Arab Emirates - from left to right : Alya Ali Binghurair, Shaikha Al Kalbani, Professor Chafia Hejase de Trad, Mariam Al Hassani, Aminah Al Abdouli.

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Summer students and professor from the United Arab Emirates - from left to right : Alya Ali Binghurair, Shaikha Al Kalbani, Professor Chafia Hejase de Trad, Mariam Al Hassani, Aminah Al Abdouli.

  14. Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI.

    Science.gov (United States)

    Lakshmi, Sowmya P; Reddy, Aravind T; Naik, Meghna U; Naik, Ulhas P; Reddy, Raju C

    2012-11-01

    Transmigration of neutrophils (PMNs) from the vasculature into inflamed tissues, mediated by interactions between PMNs and adhesion molecules on endothelial cells, is an essential aspect of inflammation. The crucial adhesion molecules include junctional adhesion molecule (JAM)-A. Investigation of the role of this molecule in models of inflammatory disease has been limited, however, and results in different disease models have varied. No previous study has addressed JAM-A in lung disease or effects on oxidant stress and proinflammatory cytokines. We use JAM-A knockout mice and blocking antibodies to investigate the role of JAM-A in a murine model of acute lung injury (ALI). With either experimental system, we find that absence of JAM-A activity significantly reduces migration of PMNs into the alveolar space, with a resulting decrease in oxidative stress. However, there is no reduction in whole lung activity of PMN-associated myeloperoxidase, presumably reflecting the histologically observed retention of PMNs in lung tissue. Activity of these retained PMNs may account for our failure to find significant change in markers of lung oxidative stress or cytokine and chemokine levels in plasma, lung, and bronchoalveolar lavage fluid. We likewise see no JAM-A-related changes in markers of capillary permeability or lung injury. A similar lack of congruence between effects on PMN migration and tissue injury has been reported in other disease models and for other adhesion molecules in models of ALI. Our results thus confirm the crucial role of JAM-A in PMN transmigration but demonstrate that transmigration is not essential for other aspects of inflammation or for lung injury in ALI.

  15. Preparation and Luminescence Properties of MZrO3:Eu3+, A (M=Ca2+, Ba2+; A=Li+, Na+, K+) Phosphors with Perovskite Structure

    Institute of Scientific and Technical Information of China (English)

    MAR B; CEMBRERO-COCA P; SINGH K C; KAUSHIK R D; OM Hari

    2013-01-01

    Calcium and barium zirconate powders based upon CaZrO3:Eu3+, A and BaZrO3:Eu3+, A (A=Li+, Na+, K+) were prepared by combustion synthesis method and heating to ~1000 °C to improve crystal inity. The structure and morphology of materials were examined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). XRD results showed that CaZrO3:Eu3 +, A and BaZrO3:Eu3 +, A (A=Li +, Na +, K +) perovskites possessed orthorhombic and cubic structures, respectively. The morphologies of al powders were very similar consisting of smal , coagulated, cubical particles with narrow size distributions and smooth and regular surfaces. The characteristic luminescences of Eu3+ ions in CaZrO3:Eu3+, A (A=Li+, Na+, K+) lattices were present with strong emissions at 614 and 625 nm for 5D0→7F2 transitions with other weaker emissions observed at 575, 592, 655, and 701 nm corresponding to 5D0→7Fn transitions (where n=0, 1, 3, 4, respectively). In BaZrO3:Eu3 + both the 5D0→7F1 and 5D0→7F2 transitions at 595 and 613 nm were strong. Photoluminescence intensities of CaZrO3:Eu3+ samples were higher than those of BaZrO3:Eu3+ lattices. This remarkable increase of photoluminescence intensity (corresponding to 5D0→7Fn transitions) was observed in CaZrO3:Eu3 + and BaZrO3:Eu3 + if co-doped with Li + ions. An additional broad band composed of many peaks between 440 to 575 nm was observed in BaZrO3:Eu3 +, A samples. The intensity of this band was greatest in Li+ co-doped samples and lowest for K+ doped samples.

  16. Investigation on the geomorphological characteristics of the Kabutar Ali Chai watershed (NW Iran) and their role in flood production

    Science.gov (United States)

    Jananeh, Keristineh

    2016-04-01

    The Kabutar Ali Chai watershed is located in NW Iran, 75 km northwest of Tabriz, on the southern hillsides of Mishow mountains. It occupies an area of 67.46 km2 and the length of the main stream is about 24.5 km. Due to the fact that flooding in this watershed threats the downstream rural areas, an investigation was carried out to extract its geomorphologic characteristics and evaluate their contribution in flood production. In this regard, the watershed area was divided into 4 sections based on physiographic and topographic characteristics and stream network: A1 (the southern, low-height part), A2 (mid-western half), A3 (mid-eastern half) and A4 (the northern and highest part). Hypsometric maps and diagrams prepared for the area show that it is confined between 1390 and 3230m elevation levels with a general dip towards the south. The main part of it (57.93%) is located between the elevation levels of 1390 and 1500m. Using the precipitation records of 4 neighboring stations for 20 years, the estimated time of concentration for the runoff varies in the sub-zones: 1.64 hr in A1 (13.9 km stream length and 710 m altitude difference), 0.63 hr in A2 (7.2 km and 1200 m), 0.35 hr in A3 (4.7 km and 1530 m) and 0.48 hr in A4 (5.9 km and 1330 m.) Dip angle is one of the most important factors affecting the time of concentration for runoff and flood production. The average dip of the main part of the area (79.82%) ranges between 0 and 5°, while only the 0.44% of the area has dips about 30-40°. Highest dips are found in the A4 zone (0-40°) and the weight average dip of the total area is 12.94%. Geologically, the most widespread rocks are Pre-Cambrian shales, schists and limestones (Kahar Formation, 43.53%), upper-Cretaceous flysch sequence comprised of shale, limestone and sandstone (13.99%), Miocene marls, silts, clays and limestones (4.13%) and Quaternary alluvial terraces and plains (30.33%). Geomorphologically, this watershed is comprised of 3 types of lands: (1

  17. Technical feasibility of a seabed gallery seawater intake at Ras Abu Ali Island, Arabian Gulf, Saudi Arabia

    KAUST Repository

    Rachman, Rinaldi

    2014-07-23

    Open-ocean intake systems require extensive and advanced pretreatment unit operation to produce feed water with low membrane fouling potential in seawater reverse osmosis (SWRO) facilities. Alternatively, subsurface intake systems tend to produce high quality raw seawater even before pretreatment. Subsurface intakes extract seawater indirectly through the geological structure of shoreline or nearshore sediments. Water percolation through geological units provides physical and biological treatment, so that the raw seawater is microbiologically stable with relatively low particulate and organics content. Overall, utilization of subsurface intakes will reduce the intensity of pretreatment, which reduces operating cost, lowers chemical and energy consumption, and reduces environmental impacts. An important aspect in the feasibility of a subsurface intake is the compatibility of the local geological environment. In this study, a field investigation was conducted at Ras Abu Ali Island in the Arabian Gulf. This location currently contains an of existing oil company facilities and a proposed governmental marine fish hatchery facility. Recreational, commercial, and domestic potable water uses require the need to use the SWRO process to meet demands. Characterization of the shoreline and marine offshore bottom were performed as well as observation of tidal fluctuations and wave heights. A specific grid area was chosen where 35 sediment samples were collected from the seabed floor for laboratory analysis of grain size distribution, sediment porosity, and hydraulic conductivity. Onsite observation showed that the marine bottom has a low slope creating a wide intertidal area. The lowest tidal zone is more than 150 m from the shoreline defining a far seaward boundary for the intake construction point. A relatively thin layer of mixed-type sediment (carbonate and siliciclastic) covers the marine hardground bottom. The unlithified bottom sediment contains a low mud percentage

  18. Investigations of the Biological Effects of Airborne and Inhalable Substances by Cell-Based In Vitro Methods: Fundamental Improvements to the ALI Concept

    Directory of Open Access Journals (Sweden)

    Detlef Ritter

    2014-01-01

    Full Text Available The state of the art for cell-based in vitro investigations of airborne and inhalable material is “air-liquid interface” (ALI technology. Cell lines, primary cells, complex 3D models, or precision-cut lung slices (PCLS are used to represent the lung or skin by way of an in vitro barrier model. These models have been applied in toxicity or pharmacological testing. However, contrasting with a clear demand for alternative methods, there is still no widely accepted procedure for cell-based in vitro testing of inhalable substances. In the light of this, an analysis was undertaken of common drawbacks of current approaches. Hence, the pivotal improvements aimed at were the cellular exposure environment, overall performance and applicability, operability of online investigations during exposure and routine setup. It resulted in an improved device (P.R.I.T. ExpoCube based on an “all-in-one-plate” concept including all phases of the experiment (cell culture, exposure, and read-out and all experimental groups (two test gas groups, controls in one single commercial multiwell plate. Verification of the concept was demonstrated in a first experimental series using reference substances (formaldehyde, ozone, and clean air. The resulting ALI procedure enables the application of inhalable substances and mixtures under highly effective exposure conditions in routine utilization.

  19. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.

    Science.gov (United States)

    Zhang, Ting; Liu, Yong; Yang, Xianshu; Martin, Gary E; Yao, Huifang; Shang, Jackie; Bugianesi, Randal M; Ellsworth, Kenneth P; Sonatore, Lisa M; Nizner, Peter; Sherer, Edward C; Hill, Susan E; Knemeyer, Ian W; Geissler, Wayne M; Dandliker, Peter J; Helmy, Roy; Wood, Harold B

    2016-03-10

    A potent and selective Factor IXa (FIXa) inhibitor was subjected to a series of liver microsomal incubations, which generated a number of metabolites. Using automated ligand identification system-affinity selection (ALIS-AS) methodology, metabolites in the incubation mixture were prioritized by their binding affinities to the FIXa protein. Microgram quantities of the metabolites of interest were then isolated through microisolation analytical capabilities, and structurally characterized using MicroCryoProbe heteronuclear 2D NMR techniques. The isolated metabolites recovered from the NMR experiments were then submitted directly to an in vitro FIXa enzymatic assay. The order of the metabolites' binding affinity to the Factor IXa protein from the ALIS assay was completely consistent with the enzymatic assay results. This work showcases an innovative and efficient approach to uncover structure-activity relationships (SARs) and guide drug design via microisolation-structural characterization and ALIS capabilities.

  20. The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable.

    Science.gov (United States)

    Johnson, Lisa A; Li, Ling; Sandri-Goldin, Rozanne M

    2009-07-01

    Herpes simplex virus 1 (HSV-1) protein ICP27 has been shown to shuttle between the nucleus and cytoplasm and to bind viral RNA during infection. ICP27 was found to interact with the cellular RNA export adaptor protein Aly/REF, which is part of the TREX complex, and to relocalize Aly/REF to viral replication sites. ICP27 is exported to the cytoplasm through the export receptor TAP/NXF1, and ICP27 must be able to interact with TAP/NXF1 for efficient export of HSV-1 early and late transcripts. We examined the dynamics of ICP27 movement and its localization with respect to Aly/REF and TAP/NXF1 in living cells during viral infection. Recombinant viruses with a yellow fluorescent protein (YFP) tag on the N or C terminus of ICP27 were constructed. While the N-terminally tagged ICP27 virus behaved like wild-type HSV-1, the C-terminally tagged virus was defective in viral replication and gene expression, and ICP27 was confined to the nucleus, suggesting that the C-terminal YFP tag interfered with ICP27's C-terminal interactions, including the interaction with TAP/NXF1. To assess the role of Aly/REF and TAP/NXF1 in viral RNA export, these factors were knocked down using small interfering RNA. Knockdown of Aly/REF had little effect on the export of ICP27 or poly(A)(+) RNA during infection. In contrast, a decrease in TAP/NXF1 levels severely impaired export of ICP27 and poly(A)(+) RNA. We conclude that TAP/NXF1 is essential for ICP27-mediated export of RNA during HSV-1 infection, whereas Aly/REF may be dispensable.

  1. Geochemistry of rare earth elements in the Baba Ali magnetite skarn deposit, western Iran – a key to determine conditions of mineralisation

    Directory of Open Access Journals (Sweden)

    Zamanian Hassan

    2016-03-01

    Full Text Available The Baba Ali skarn deposit, situated 39 km to the northwest of Hamadan (Iran, is the result of a syenitic pluton that intruded and metamorphosed the diorite host rock. Rare earth element (REE values in the quartz syenite and diorite range between 35.4 and 560 ppm. Although the distribution pattern of REEs is more and less flat and smooth, light REEs (LREEs in general show higher concentrations than heavy REEs (HREEs in different lithounits. The skarn zone reveals the highest REE-enriched pattern, while the ore zone shows the maximum depletion pattern. A comparison of the concentration variations of LREEs (La–Nd, middle REEs (MREEs; Sm–Ho and HREEs (Er–Lu of the ore zone samples to the other zones elucidates two important points for the distribution of REEs: 1 the distribution patterns of LREEs and MREEs show a distinct depletion in the ore zone while representing a great enrichment in the skarn facies neighbouring the ore body border and decreasing towards the altered diorite host rock; 2 HREEs show the same pattern, but in the exoskarn do not reveal any distinct increase as observed for LREEs and MREEs. The ratio of La/Y in the Baba Ali skarn ranges from 0.37 to 2.89. The ore zone has the highest La/Y ratio. In this regard the skarn zones exhibit two distinctive portions: 1 one that has La/Y >1 beingadjacent to the ore body and; 2 another one with La/Y < 1 neighbouring altered diorite. Accordingly, the Baba Ali profile, from the quartz syenite to the middle part of the exoskarn, demonstrates chiefly alkaline conditions of formation, with a gradual change to acidic towards the altered diorite host rocks. Utilising three parameters, Ce/Ce*, Eu/Eu* and (Pr/Ybn, in different minerals implies that the hydrothermal fluids responsible for epidote and garnet were mostly of magmatic origin and for magnetite, actinolite and phlogopite these were of magmatic origin with low REE concentration or meteoric water involved.

  2. Pb-Zn mineralization of Ali ou Daoud area (Central High Atlas, Morocco: characterisation of deposit and relationship with the clay assemblages

    Directory of Open Access Journals (Sweden)

    Daoudi, L.

    2008-12-01

    Full Text Available Zn-Pb-Fe ores in the Ali ou Daoud deposit (Central High Atlas are found as stratiform levels and as karst fillings in carbonate platforms facies of Bajocian age. Tectonic structures (e.g., synsedimentary faults played a relevant role in the ore emplacement. The dolomitic ore-related host-rock levels are characterized by the presence of kaolinite enrichment in clay levels in amounts directly related to the proportion of the clay minerals. The latter is evidenced by correlation between kaolinite and sulphide contents, suggesting that the installation of kaolinite and mineralisations would result from the same hydrothermal fluid.[Français] Dans les séries sédimentaires carbonatées d’Ali ou Daoud (Haut Atlas Central, les minéralisations à Zn, Pb et Fe en amas stratiformes forment les faciès de remplissage des karsts d’une plateforme carbonatée bajocienne. Le contrôle structural joue un rôle capital dans la localisation du gîte en bordure de plateforme sur des failles synsédimentaires. Dans les niveaux dolomitiques encaissants des minéralisations, les assemblages argileux sont caractérisés par la présence de kaolinite dont la teneur varie parallèlement avec celle du minerai. Ceci suggère que la mise en place de la kaolinite et des minéralisations résulterait du même fluide hydrothermal. [Español] En las series sedimentarias carbonatadas de Ali ou Daoud (Alto Atlas Central, las mineralizaciones de Zn, Pb y Fe aparecen en niveles estratiformes como facies de reemplazamiento de los karsts de una plataforma carbonatada Bajociense. El control estructural desempeña un papel crucial en la localización del yacimiento a lo largo de la plataforma sobre fallas sinsedimentarias. En los niveles dolomíticos que incluyen las mineralizaciones, las asociaciones arcillosas se caracterizan por la presencia de caolinita, cuyo contenido varía paralelamente al de la mineralización. Esto sugiere que la creación de caolinita y de la

  3. Actividades económicas primarias predominantes en la Reserva Paisajística Nor Yauyos Cochas, Perú. Caso: distritos de Huancaya, Alis y Vitis

    Directory of Open Access Journals (Sweden)

    Wilfredo Bulege Gutiérrez

    2011-12-01

    Full Text Available Objetivos: Determinar las actividades económicas primarias predominantes en los distritos de Huancaya, Alis y Vitis de la provincia de Yauyos, región Lima, ubicados en la zona de aprovechamiento directo de la Reserva Paisajística Nor Yauyos Cochas. Métodos: Es una investigación de tipo básica, alcance descriptiva, diseño transversal, en el proceso de recolección de datos se aplicó un cuestionario estructurado a una muestra no probabilística de 79 personas con edades mayores a 18 años entre varones y mujeres de los distritos de Huancaya, Alis y Vitis, quienes participaron en un evento académico sobre “Econegocios para el desarrollo” organizado por Grupo de Proyección Social “Eco-negocios” de la Universidad Continental, este mismo instrumento se aplicó a personas ubicadas circunstancialmente en la vía pública de los mencionados distritos hasta completar el tamaño muestral de 79. Resultados: El 42% manifiesta que se dedica principalmente a la agricultura; 37%, a la ganadería; 5%, a la acuicultura; 5%, a la artesanía y un 11% a otras actividades entre las cuales se puede identificar el comercio, servicios turísticos, minería, etc. Las personas cuya actividad principal es la agricultura manifestaron que el 44% de su producción es maíz; 28%, papa; 23%, trigo y 5% otros productos. Las personas dedicadas a la ganadería manifestaron que el 41%, cría camélidos; 28%, vacunos; 14%, ovinos y un 17%, otros. Conclusiones: La población de los distritos de Huancaya, Alis y Vitis dedican como una de sus actividades económicas de mayor predominancia a la agricultura, luego la ganadería, siendo este un indicador importanteque caracteriza a estos distritos como zonas con una economía basada en actividades primarias, es decir extractiva de recursos naturales y aprovechada prioritariamente para autoconsumo y su comercialización.

  4. THE EFFECTS OF THE ATTACKS TO ANATOLIA BY MEHMED ALI PASHA ON NİĞDE AND NEVŞEHİR PROVINCES

    Directory of Open Access Journals (Sweden)

    Efkan UZUN

    2012-08-01

    Full Text Available Mehmed Ali Pasha was the absolute ruler in Egypt since the Ottoman Empire was in very bad situation at that time as a result of some events. Mehmed Ali Pasha was among the soldiers sent to Egypt upon the invasion of the country by Napoleon. When his help was demanded to eliminate the rebellion in the Morea by the Sultan Mahmud the second of the Ottoman Empire, he wanted to be the governor of theMorea and the Crete Island in return for its help. However, when the Morea was taken by independent Greece in Edirne Treaty, therefore, he wanted to be the governor of Syria in place of the Morea. Sultan Mahmut the Second accepted to appoint him as the governor of the Crete Island but not Syria. As a result of this disagrement, he rebelled against the rule of The Ottoman Empire. His son, IbrahimPasha, invaded Syria with his Egyptian troops and he defeated the Ottoman army in Adana and Konya. He reached as far as Kutahya Province. The capital city, Istanbul,was in jeopardy and Sultan Mahmut the second, had to demand the aidof the Russians.When the Russian Navy reached Istanbul, England and France became worried about the situation. The domestic problem turned into an international one.The problem was solved temporarily by Kutahya Treaty signed by related states.In our study, issues related to the event such as the critical situations at that time, the worries of the people of the provinces, the technical and military support given to the empire by the provinces during Ibrahim Pasha's attacks, son of Mehmed Ali Pasha were discussed in the light of some documents and data emerged lately.The aim of the study is to introduce and discuss the event with a different aspect. Therefore, the studies about the subject done so far and documents in the archives of the empire were used. Screening model, one of the qualitative research was used in the study.

  5. Être correspondant régional en Tunisie : De l’aliénation au pouvoir à la liberté totale

    OpenAIRE

    Bour, Hamida El

    2017-01-01

    Les soulèvements qui se sont déroulés en Tunisie du 17 décembre 2010 au 14 janvier 2011 montrent combien les media tunisiens ont occulté l’information à l’intérieur du pays. Sous l’ancien régime de Ben Ali, les media se tenaient loin des préoccupations et des réalités locales des citoyens. Cet article compare la couverture médiatique tunisienne pour les informations locales avant et après la révolution à travers le vécu de 16 correspondants locaux. La Tunisie compte 27 correspondants locaux e...

  6. Analyse statistique de l'assemblage acier/aluminium réalisé par le procédé de soudage MIG-CMT

    OpenAIRE

    Mezrag, Bachir; Benachour, Mustapha; Deschaux Beaume, Frédéric

    2014-01-01

    International audience; La dépendance vis-à-vis des paramètres de soudage de la géométrie de l'assemblage hétérogène acier/aluminium réalisé par le procédé MIG-CMT dans une configuration à clin est étudiée à travers un plan d'expérience. Les paramètres choisis comme facteurs d'influence sont la puissance de soudage, la distance entre la torche et la pièce ou "stick-out", le débit de gaz et la vitesse de soudage, tandis que les caractéristiques géométriques sélectionnées comme fonctions object...

  7. Advance in the diagnosis and treatment of ALI/ARDS%急性肺损伤/急性呼吸窘迫综合征诊治进展

    Institute of Scientific and Technical Information of China (English)

    孙辉明; 施毅

    2009-01-01

    @@ 自Ashbaugh于1967年首先报道成人呼吸窘迫综合征(adult respiratory distress syndrome,ARDS)以来,人们对此病的认识日趋加深.至上世纪90年代,学者发现此病并非仅限于成人,儿童同样可患此病,因而改名为急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS),但其英文缩写名不变,仍为ARDS.急性肺损伤(ALI)是与ARDS在病因、发病机制、治疗原则等均为相同的一组综合征,因此,本文将ALI与ARDS一起进行介绍.

  8. First-principles study of the magnetic and electronic properties of AMnAs (A=Li, Na, K, Rb, Cs)

    Science.gov (United States)

    Zhou, Wenqi; Wu, Shuxiang; Li, Shuwei

    2016-12-01

    Recent studies have demonstrated that antiferromagnetic (AFM) semiconductors are promising alternative materials for spintronic applications. In this work, we report a detailed investigation of the magnetic and electronic properties of AMnAs (A=Li, Na, K, Rb, Cs) using density functional theory. It is found that all studied compounds are ordered antiferromagnetically in the MnAs ab plane, however, along the c axis, NaMnAs is ordered ferromagnetically which is different from the AFM coupling of other materials. These results on magnetic structures are in good agreement with observed facts. Furthermore, our calculations predict that all materials have a semiconducting band structure, which indicates the potential of device applications.

  9. Oferta ir akceptas kaip šalių valios sudaryti sutartį išraiška – teoriniai ir praktiniai aspektai

    OpenAIRE

    Karpickis, Kazimieras

    2011-01-01

    Šiame magistro baigiamajame darbe atskleidžiama ofertos ir akcepto, kaip asmens valios išraiškos aktų, teisinė prigimtis. Kadangi teisės doktrinoje ir teismų praktikoje oferta ir akceptas yra prilyginami vienašaliams sandoriams, darbe oferta ir akceptas yra analizuojami sandorių ir vienos iš jų rūšies, t. y. vienašalių sandorių, atžvilgiu. Pirmajame darbo skyriuje analizuojama asmens valia ir jos išraiška bei prieinama išvados, jog bendrąja prasme, nevertinant ofertos ir akcepto teisinės prig...

  10. Pb-Zn mineralization of the Ali ou Daoud area (Central High Atlas, Morocco): characterisation of the deposit and relationships with the clay assemblages; Mineralisation Pb-Zn du type MVT de la region d'Ali ou Daoud (Haut Atlas Central, Maroc): caracterisations du gite et relations avec les corteges de mineraux argileux

    Energy Technology Data Exchange (ETDEWEB)

    Mouguina, E. M.; Daoudi, L.

    2008-07-01

    Zn-Pb-Fe ores in the Ali ou Daoud deposit (Central High Atlas) are found as stratiform levels and as karst fillings in carbonate platforms facies of Bajocian age. Tectonic structures (e.g., syn sedimentary faults) played a relevant role in the ore emplacement. The dolomitic ore-related host-rock levels are characterized by the presence of kaolinite enrichment in clay levels in amounts directly related to the proportion of the clay minerals. The latter is evidenced by correlation between kaolinite and sulphide contents, suggesting that the installation of kaolinite and mineralizations would result from the same hydrothermal fluid. (Author) 55 refs.

  11. Synthesis and optical properties of turquoise- and green-colored brownmillerite- type Ba2In2-x-yMnxAlyO5+x codoped with manganese and aluminum

    Institute of Scientific and Technical Information of China (English)

    Peng Jiang; Wen-hui Yang; Yun-cheng Zhou; Jian-lei Kuang; Yong Li; Ting Xiao

    2016-01-01

    Brownmillerite-type oxides Ba2In2−x−yMnxAlyO5+x (0≤x≤ 0.6, 0≤y≤ 0.5) were prepared at 1300°C through solid-state reaction. X-ray diffraction (XRD) analysis showed that the structure symmetry evolved from orthorhombic to cubic with increasing Mn and Al con-tents. Wheny was greater than 0.3, peaks associated with small amounts of BaAl2O4 and Ba2InAlO5 impurities were observed in the XRD patterns. When substituted with a small amount of Mn (x≤ 0.3), the Ba2In2−x−yMnxAlyO5+x samples exhibited an intense turquoise color. The color changed to green and dark-green with increasing Mn concentration. UV–vis absorbance spectra revealed that the color changed only slightly upon Al doping. The valence state of Mn ions in Ba2In2−x−yMnxAlyO5+x was confirmed to be +5 on the basis of X-ray photoelectron spectroscopic analysis. According to this analysis, the intense turquoise color of the Ba2In2−x−yMnxAlyO5+x samples is rooted in the existence of Mn5+; thus, the introduction of Al does not affect the optical properties of the compounds.

  12. Geochemistry, Petrology, and Provenance of Magnetite-Rich Ortaklar Cu Deposit Hosting Basalts from Koçali Complex, Gaziantep, Turkey

    Science.gov (United States)

    Yun, E.; Lee, I.; Kang, J.; Dönmez, C.; Yildirim, N.

    2015-12-01

    Magnetite-rich Cyprus type VMS deposit has been recently discovered from the Ortaklar-Gaziantep region within Koçali complex, SE Turkey. Magnetite rich sulfide ore bodies are in close contact with underlying footwall spilitic basalts. These basalts are part of Koçali mélange, which represents an accreted oceanic complex during closing of southern Neotethys. These extrusives are low-K, low alkali tholeiites with Ca rich, partially sericitized plagioclase subophitically enclosed by augite with disseminated Fe-Ti oxides and pyrite. Mineral crystallization sequence of plagioclase followed by augite and opaque is typical of MORB. Major and trace element analyses for least altered basalts based on LOI (1.5~3.6 wt%), Ce/Ce* (0.9~1.1) exhibit limited range of element abundances. Low Mg# (59~60) suggests that basalts were derived from moderately evolved magma with fractional crystallization. HFSE (Th, Nb, Hf, Zr) were used for tectonic discrimination and basalts were plotted within MORB end spectrum, near MORB-IAT boundary. N-MORB normalized La to Lu ranges from 0.4 to 0.9 times N-MORB with LREE depletion [(La/Sm)N = 0.58~0.67] and flat HREE [(Tb/Lu)N = 0.95~1.05]. Chondrite normalized REE patterns resemble those of N-MORB but characterized by severe LREE depletion [(La/Sm)CN = 0.35~0.45]. LREE depletion coupled with high Sm/Nd (0.36~0.43), high CaO/Na2O (5.0~6.2) and low Nb/Yb (0.23~0.39) suggest depleted N-MORB composition derived from the refractory mantle source. Analyzed basalts are similar to those found from other rift (Costa Rica Rift Hole 504b) and intra-transform fault (Siqueiros transform). Magnetite emplacement occurring close to the ore-host boundary and lack of pyrrhotite from hosting basalts imply an involvement of oxidized hydrothermal fluids. Basalts probably have formed by late stage, partial melting of the refractory mantle at low pressure, shallow depth, and H2O rich environment. Possible source of mantle heterogeneity can be identified by isotope

  13. UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.

    Science.gov (United States)

    Hautbergue, Guillaume M; Hung, Ming-Lung; Walsh, Matthew J; Snijders, Ambrosius P L; Chang, Chung-Te; Jones, Rachel; Ponting, Chris P; Dickman, Mark J; Wilson, Stuart A

    2009-12-01

    Messenger RNA (mRNA) export adaptors play an important role in the transport of mRNA from the nucleus to the cytoplasm. They couple early mRNA processing events such as 5' capping and 3' end formation with loading of the TAP/NXF1 export receptor onto mRNA. The canonical adaptor REF/ALY/Yra1 is recruited to mRNA via UAP56 and subsequently delivers the mRNA to NXF1 [1]. Knockdown of UAP56 [2, 3] and NXF1 [4-7] in higher eukaryotes efficiently blocks mRNA export, whereas knockdown of REF only causes a modest reduction, suggesting the existence of additional adaptors [8-10]. Here we identify a new UAP56-interacting factor, UIF, which functions as an export adaptor, binding NXF1 and delivering mRNA to the nuclear pore. REF and UIF are simultaneously found on the same mRNA molecules, and both proteins are required for efficient export of mRNA. We show that the histone chaperone FACT specifically binds UIF, but not REF, via the SSRP1 subunit, and this interaction is required for recruitment of UIF to mRNA. Together the results indicate that REF and UIF represent key human adaptors for the export of cellular mRNAs via the UAP56-NXF1 pathway.

  14. IMPACT DE L’ORIENTATION SUR LE CONFORT THERMIQUE INTERIEUR DANS L’HABITATION COLLECTIVE : Cas de la nouvelle ville Ali Mendjeli, Constantine

    Directory of Open Access Journals (Sweden)

    S BELLARA LOUAFI

    2009-06-01

    Une étude est effectuée sur le site de la nouvelle ville ALI MENDJELI de Constantine afin de comparer et de chercher la relation entre les éléments du climat et l’orientation. Une investigation sur terrain (relevé des températures, humidité relatives, températures de surfaces est entreprise pour évaluer la réponse quantitative globale pour ce type de climat (semi aride. Parallèlement à cela une simulation à l’aide d’un logiciel TRNSYS (version 14.1 a été effectuée pour tester plusieurs possibilités d’orientations et d’améliorations afin de déterminer les éléments qui peuvent servir à des conditions meilleures. Les résultats montrent que la prise en compte du critère orientation fait participer le bâtiment à une conception plus performante thermiquement et plus économe énergétiquement.

  15. Binding energies of shallow impurities in asymmetric strained wurtzite AlxGa1-xN/ GaN/Aly Ga1-yN quantum wells*

    Institute of Scientific and Technical Information of China (English)

    Ha Sihua; Ban Shiliang; Zhu Jun

    2011-01-01

    The ground state binding energies of hydrogenic impurities in strained wurtzite AlxGa1-xN/GaN/AlyGa1-yN quantum wells are calculated numerically by a variational method. The dependence of the binding energy on well width, impurity location and Al concentrations of the left and right barriers is discussed, including the effect of the built-in electric field induced by spontaneous and piezoelectric polarizations. The results show that the change in binding energy with well width is more sensitive to the impurity position and barrier heights than the barrier widths, especially in asymmetric well structures where the barrier widths and/or barrier heights differ. The binding energy as a function of the impurity position in symmetric and asymmetric structures behaves like a map of the spatial distribution of the ground state wave function of the electron. It is also found that the influence on the binding energy from the Al concentration of the left barrier is more obvious than that of the right barrier.

  16. Sociological Review of Literatüre of Opportunity For Analysıs of The Ballad of Ali of Keshan

    Directory of Open Access Journals (Sweden)

    Mustafa KARABULUT

    2012-06-01

    Full Text Available Theatre, as a kind of Western modern sense began to appear in Turkish literature from the Tanzimat period on. Muhsin Ertuğrul, several authors have also grown at the initiative of the Republican era. Haldun Taner, who is an important process in the world of literature as the author replaces. He works in the works of modern and traditional elements together successfully. The author has greatly contributed to the modern Turkish theater in the formation and progression. Although many games to write Taner, Epic is known for not Pay. This works in our country, now a pioneer of epic theater, the first native, gave an instance of musical play. Haldun Taner, a critical perspective, the community The Ballad of Ali of Keshan. In this game, the conflict between urbanization and urban life, social distortions, administrators negligence, economic problems and so on. issues be heard. The author, using the power of literature, social, community life in the 1960s, offers cross-sections.

  17. Effect of integrated pest management on controlling zoonotic cutaneous leishmaniasis in Emamzadeh Agha Ali Abbas (AS) District, Isfahan province, 2006-2009

    Science.gov (United States)

    Nilforoushzadeh, Mohammad Ali; Shirani-Bidabadi, Leila; Saberi, Sedigheh; Hosseini, Seyed Mohsen; Jaffary, Fariba

    2014-01-01

    Background: Cutaneous leishmaniasis (CL) is still considered as a health problem in the world. Several methods of control in different regions, together with obtaining integrated information on its natural foci, are needed to decrease its prevalence. This study was designed to evaluate the effects of simultaneous interventions on CL control. Materials and Methods: A standard questionnaire was used to identify patients among pilgrims to Emamzadeh Agha Ali Abbas (Isfahan Province, Iran). Subsequently, three methods of controlling the disease, including, spraying residential buildings with Baygon, baiting with zinc phosphide poisons, changing the vegetative cover of the region, improving the environment, and mounting a mesh on all doors and windows of buildings in residential areas were used. The control measures were then evaluated by comparing the number of pilgrims affected by CL after and before the interventions. Results: While 23 pilgrims (1.4%) were affected with CL before the intervention (pretest), five (0.3%) persons were found to have CL after taking control measures. The Chi-square test did not indicate any significant difference in the relative frequency of CL (P = 0.731). Conclusion: The only scientific method for preventing and controlling zoonotic CL (ZCL) is a combination of the control methods (improving the environment and fighting off the disease districts and vectors) together with changing the vegetative cover of the region. Any measure for controlling this disease must be taken and programmed in accordance with the relevant experts’ views, in coordination with the participation of other organizations and the society. PMID:24818102

  18. Raman scattering of magnetic excitations in Y1-x Prx Ba2Cu3-yAlyO7-δ single crystals

    Science.gov (United States)

    Rübhausen, M.; Dieckmann, N.; Bock, A.; Merkt, U.; Widder, W.; Braun, H. F.

    1996-11-01

    Magnetic excitations and their role for the superconductivity in cuprate superconductors have been widely discussed in the literature. Here, we present a study of Y1-x Prx Ba2Cu3-yAlyO7-δ single crystals using Raman spectroscopy in an energy range of 50 10000 cm-1 Raman shift. The high energy range is dominated by a two-magnon scattering process at 3J, where J is the superexchange energy. In the Pr-123 single crystal, we find J = 720 cm-1, a damping of the one-magnon states Γ = 200 cm-1, and a resonance energy of 2.79eV for the two-magnon excitation. The two-magnon peak shows a continuous increase of the one-magnon damping with decreasing x and a nearly constant J across the phase transition to the superconductor. Especially, we find a weak two-magnon peak for a superconductor with a Tc = 86 K.

  19. Crystal structures of hydrates of simple inorganic salts. III. Water-rich aluminium halide hydrates: AlCl3 · 15H2O, AlBr3 · 15H2O, AlI3 · 15H2O, AlI3 · 17H2O and AlBr3 · 9H2O.

    Science.gov (United States)

    Schmidt, Horst; Hennings, Erik; Voigt, Wolfgang

    2014-09-01

    Water-rich aluminium halide hydrate structures are not known in the literature. The highest known water content per Al atom is nine for the perchlorate and fluoride. The nonahydrate of aluminium bromide, stable pentadecahydrates of aluminium chloride, bromide and iodide, and a metastable heptadecahydrate of the iodide have now been crystallized from low-temperature solutions. The structures of these hydrates were determined and are discussed in terms of the development of cation hydration spheres. The pentadecahydrate of the chloride and bromide are isostructural. In AlI(3) · 15H2O, half of the Al(3+) cations are surrounded by two complete hydration spheres, with six H2O in the primary and 12 in the secondary. For the heptadecahydrate of aluminium iodide, this hydration was found for every Al(3+).

  20. A comparison between HfO2/Al2O3 nano-laminates and ternary HfxAlyO compound as the dielectric material in InGaAs based metal-oxide-semiconductor (MOS) capacitors

    Science.gov (United States)

    Krylov, Igor; Pokroy, Boaz; Eizenberg, Moshe; Ritter, Dan

    2016-09-01

    We compare the electrical properties of HfO2/Al2O3 nano-laminates with those of the ternary HfxAlyO compound in metal oxide semiconductor (MOS) capacitors. The dielectrics were deposited by atomic layer deposition on InGaAs. Water, ozone, and oxygen plasma were tested as oxygen precursors, and best results were obtained using water. The total dielectric thickness was kept constant in our experiments. It was found that the effective dielectric constant increased and the leakage current decreased with the number of periods. Best results were obtained for the ternary compound. The effect of the sublayer thicknesses on the electrical properties of the interface was carefully investigated, as well as the role of post-metallization annealing. Possible explanations for the observed trends are provided. We conclude that the ternary HfxAlyO compound is more favorable than the nano-laminates approach for InGaAs based MOS transistor applications.

  1. Revistas y producción científica de América Latina y el Caribe: su visibilidad en SciELO, RedALyC y SCOPUS

    Directory of Open Access Journals (Sweden)

    Sandra Miguel

    2011-08-01

    Full Text Available Este trabajo comparó la cobertura de revistas procedentes de América Latina y el Caribe incluidas en SciELO, RedALyC y SCOPUS, por país y por tema. Calculó el porcentaje de revistas en estas fuentes en relación con las registradas en el catálogo de LATINDEX. Estimó el volumen de la producción científica que registra visibilidad en las tres fuentes y su evolución en el período 2005-2009. Los resultados indicaron que las tres fuentes son complementarias. En promedio, el porcentaje de solapamiento de títulos es bajo y desigual la distribución de revistas por países. Ningún país registró en las fuentes estudiadas todas las revistas incluidas en LATINDEX. SCOPUS y SciELO están más equilibradas temáticamente que RedALyC, que mostró un marcado sesgo hacia las ciencias sociales. El volumen de producción científica visible en SCOPUS es muy superior al de SciELO y RedALyC, aunque su distribución por países es muy desigual. Las tres fuentes registran tendencias de crecimiento de la producción en el período analizado.

  2. Low-Cost Evaluation of EO-1 Hyperion and ALI for Detection and Biophysical Characterization of Forest Logging in Amazonia (NCC5-481)

    Science.gov (United States)

    Asner, Gregory P.; Keller, Michael M.; Silva, Jose Natalino; Zweede, Johan C.; Pereira, Rodrigo, Jr.

    2002-01-01

    quantify both the presence and degree of structural disturbance caused by various logging regimes. Our quantitative assessment of Hyperion hyperspectral and ALI multi-spectral data for the detection and structural characterization of selective logging in Amazonia will benefit from data collected through an ongoing project run by the Tropical Forest Foundation, within which we have developed a study of the canopy and landscape biophysics of conventional and reduced-impact logging. We will add to our base of forest structural information in concert with an EO-1 overpass. Using a photon transport model inversion technique that accounts for non-linear mixing of the four biogeophysical indicators, we will estimate these parameters across a gradient of selective logging intensity provided by conventional and reduced impact logging sites. We will also compare our physical ly-based approach to both conventional (e.g., NDVI) and novel (e.g., SWIR-channel) vegetation indices as well as to linear mixture modeling methods. We will cross-compare these approaches using Hyperion and ALI imagers to determine the strengths and limitations of these two sensors for applications of forest biophysics. This effort will yield the first physical ly-based, quantitative analysis of the detection and intensity of selective logging in Amazonia, comparing hyperspectral and improved multi-spectral approaches as well as inverse modeling, linear mixture modeling, and vegetation index techniques.

  3. Evaluation of Clinical Manifestations and Therapeutic and Diagnostic Progression of Dyspepsia in Children Referred to Boo-Ali Hospital of Sari in 2005-2

    Directory of Open Access Journals (Sweden)

    H. Karami, M.D.

    2007-09-01

    Full Text Available Background and purpose: Chronic abdominal pain is a common clinical problem in children. Apleys reported the incidence of 10-15% of chronic abdominal pain in school age children, but recent studies reported 20% of that type of pain. The aim of this study was determining the spectrum of clinical manifestations of dyspeptic children and to identify the relation between some clinical symptoms, organic or functional dyspepsia, and long term follow up of functional type.Materials and Methods: This descriptive case series study was done on 232 children between 4 and 18 years of age complaining about chronic abdominal pain chiefly who had referred to pediatric gastroenterology department of Boo-Ali Hospital of sari in 2005-2006. A checklist composed of patient demographic criteria and pain characteristics was prepared. Physical exam and laboratory tests such as AST, ALT, U/A, U/C, S/E, ESR, CBC were performed for all patients. If there were any alarming signs of organic abdominal pain-persistence or recurrence of symptoms and severe disability despite the use of H-blockers-upper GI endoscopies was indicated. Recorded data were analyzed by SPSS software and Chi- square tests.Results: 102 of 232 patients had dyspepsia; 59 were girls (9.2y/o, and 43 were boys (7.5y/o. 65 out of 102 patients had dominant abdominal pain and the rest had flatulence, vomiting and early fullness. 64 of them went under UGI endoscopies. 28 of 64 had mucosal erosion.Conclusion: Because the functional or organic abdominal pain has not unique diagnostic criteria, and the data about pathological change in children are fewer than that of adults we recommend the clinical findings and biochemical change of mucosa for differential diagnosis in children.

  4. Survey of characteristics of neonatal death in neonatal intensive care unit of Boo-Ali Sina educational & therapeutic center between 2003-2006

    Directory of Open Access Journals (Sweden)

    Azita Bala Ghafari

    2009-01-01

    Full Text Available , , , (Received 24 June, 2009 ; Accepted 16 September, 2009AbstractBackground and purpose: The neonatal mortality rate is an important index for evaluation of public health. It involves the death of infants under 28 days. Obviously, recognizing the characteristics of neonatal mortality in this center, may be useful for promoting the procedures in the NICU, as well as planning to impede the severe complications or death.Materials and methods: This is a descriptive study performed by analyzing the available data from the medical records of NICU patients at Boo-Ali Sina Educational & Therapeutic Center during 2003 and 2006. The number of deaths, names, and medical records number of the dead infants were collected. Among 1238 patients in the NICU, 363 deaths were reported. According to medical records, 222 deaths occurred in neonates aged 0 to 27 days. Data were collected using a checklist, the validity and reliability of which were approved by clinicians. The Descriptive methods were used in analyzing the data.Results: The findings include: 140 subjects were male (63.1%; 72 from single birth (77.5%; the age-group of mothers of 38 cases (37.7% was 20-24 y; 132 cases (59.5% resided in villages; 129 cases (58.1% with prenatal care; 120 cased of Caesarian section (54%; 155 cases (76% with birth weight lower than 2500 grams and 154 preterm (75.5%. Mortality during neonatal period was divided in two groups: early death (0-6 days 142 cases (62% and late death (7-27 days 80 cases (36%.Conclusion: Correct and exact completion of NICU forms would help undertaking descriptive and analytic epidemiologic studies.Key words: Neonatal mortality, early neonatal mortality, late neonatal mortality, NICUJ Mazand Univ Med Sci 2009; 20(74: 79-83 (Persian

  5. TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).

    Science.gov (United States)

    Tang, Mengjie; Tian, Yihao; Li, Doulin; Lv, Jiawei; Li, Qun; Kuang, Changchun; Hu, Pengchao; Wang, Ying; Wang, Jing; Su, Ke; Wei, Lei

    2014-01-01

    Acute lung injury (ALI) is an inflammatory disorder associated with reduced alveolar-capillary barrier function and increased pulmonary vascular permeability. Vasodilator-stimulated phosphoprotein (VASP) is widely associated with all types of modulations of cytoskeleton rearrangement-dependent cellular morphology and function, such as adhesion, shrinkage, and permeability. The present studies were conducted to investigate the effects and mechanisms by which tumor necrosis factor-alpha (TNF-α) increases the tight junction permeability in lung tissue associated with acute lung inflammation. After incubating A549 cells for 24 hours with different concentrations (0-100 ng/mL) of TNF-α, 0.1 to 8 ng/mL TNF-α exhibited no significant effect on cell viability compared with the 0 ng/mL TNF-α group (control group). However, 10 ng/mL and 100 ng/mL TNF-α dramatically inhibited the viability of A549 cells compared with the control group (*pTNF-α for 24 hours displayed significantly increased cell permeability (*pinhibition of VASP expression increased the cell permeability (*pTNF-α in lung tissues and serum significantly increased at one hour, and the value reached a peak at four hours. Moreover, the Evans Blue absorption value of the mouse lung tissues reached a peak at four hours. The HIF-1α protein expression level in mouse lung tissues increased significantly at four hours and eight hours (**pTNF-α to inhibit VASP expression and to modulate the acute pulmonary inflammation process, and these molecules play an important role in the impairment of the alveolar-capillary barrier.

  6. Study of the growth, reproductive biology and abundance for invasive shrimpsPalaemon elegans Rathke from Garmat Ali river Basrah, Southern Iraq

    Institute of Scientific and Technical Information of China (English)

    Khaled Khasaf Al-Khafaji; Imad Hadi Al Qarooni; Murtatha Youssef Al Abbad; Nada Moffed Abd Al-Lateef

    2016-01-01

    Objective:To describe the growth, reproductive biology and abundance of the population of invasive shrimpsPalaemon elegans (P. elegans) in one of the branches of Garmat Ali river at Basrah, Southern Iraq. Methods:Monthly samples of the prawnP. elegans were collected with a bottom hand net (40 cm, 0.5 mm mesh) hauled over a distance of 10 m. A simple random sampling was conducted monthly between December 2012 and November 2013. Results:Seasonal changes were observed in the composition of the population of the species during the study year with the highest abundance in 2013 and the lowest abundance for the males was reported in January and for the females occurred in June. Salinity showed a significant correlation with the abundance of shrimps at the sampling site. The largest female measured 67.90 mm while the corresponding value for males was 61.31 mm. The proportion of ovigerous adults rose during spring season to peak on about July and ovigerous prawns were taken in all months of the year. The sex ratio indicated a preponderance of females over males in all months in the study period. Each females produced around 36–1 324 eggs and the incubation period lasted for 11–14 days at 17–29°C. Conclusions:The results of the present study indicate that this species has a wide distribution range, high density, and great reproduction potential. This study reveals the lack of researches on this species in environments of Shatt Al-Arab river and its branches. Thus,P. elegans has most likely formed a permanent population in all the brackish waters in Basrah area.

  7. Development of Antisense Therapeutic and Imaging Agents to Detect and Suppress Inducible Nitric Oxide Synthase (iNOS) Expression in Acute Lung Injury (ALI)

    Science.gov (United States)

    Shen, Yuefei

    This dissertation focuses on the development and investigation of antisense imaging and therapeutic agents, combined with nanotechnology, to detect and suppress inducible nitric oxide synthase (iNOS) expression for the diagnosis and treatment of acute lung injury (ALI). To achieve this goal, several efforts were made. The first effort was the identification and characterization of high binding affinity antisense peptide nucleic acids (PNAs) and shell-crosslinked knedel-like nanoparticle (SCK)-PNA conjugates to the iNOS mRNA. Antisense binding sites on the iNOS mRNA were first mapped by a procedure for rapidly generating a library of antisense accessible sites on native mRNAs (MASL) which involves reverse transcription of whole cell mRNA extracts with a random oligodeoxynucleotide primer followed by mRNA-specific PCR. Antisense PNAs against the antisense accessible sites were accordingly synthesized and characterized. The second effort was the investigation of cationic shell crosslinked knedel-like nanoparticle (cSCK)-mediated siRNA delivery to suppress iNOS expression for the treatment of ALI. siRNA with its unique gene-specific properties could serve as a promising therapeutic agent, however success in this area has been challenged by a lack of efficient biocompatible transfection agents. cSCK with its nanometer size and positive charge previously showed efficient cellular delivery of phosphorothioate ODNs (oligodeoxynucleotides), plasmid DNA and PNA. Herein, cSCK showed good siRNA binding and facilitated efficient siRNA transfection in HeLa, a mouse macrophage cell line and other human cell lines. cSCK led to greater silencing efficiency than Lipofectamine 2000 in HeLa cells as determined by the viability following transfection with cytotoxic and non-cytotoxic siRNAs, as well in 293T and HEK cells, and was comparable in BEAS-2B and MCF10a cells. The third effort was the preparation of an iNOS imaging probe through electrostatic complexation between a radiolabeled

  8. Lirski cikel ali lirska pesnitev?:

    OpenAIRE

    Žerjal-Pavlin, Vita

    2008-01-01

    With genre destignation, authors influence the literary reception and at least partially literary analysis. The article examines reasons for the designation "long poem", used for their texts by the contemporary Slovene poets Gregor Strniša and Boris A. Novak. Using the terms "long poem", five-part poem", and "ballad", Strniša after the fact debated with the established characterization of his texts by literary scholars as lyric sequences. Novak termed a long poem Kamnita Afrodita, one of thre...

  9. Lirski cikel ali lirska pesnitev?

    OpenAIRE

    Žerjal-Pavlin, Vita

    2015-01-01

    Avtorji z literarnovrstnimi oznakami lastnih besedil vplivajo na literarno sprejemanje in vsaj deloma tudi na literarno obdelovanje. Članek presoja razloge za poimenovanje pesnitev, ki sta ga za svoja besedila uporabila sodobna slovenska pesnika Gregor Strniša in Boris A. Novak. Strniša je s poimenovanji "pesnitev", 'petdelna pesem" oziroma "balada" naknadno polemiziral z že ustaljenim kritiškim in literarnozgodovinskim označevanjem njegovih besedil kot lirskih ciklov. Novak pa je za pesnitev...

  10. Unustatud katakombid / Claudia Haj Ali

    Index Scriptorium Estoniae

    Haj Ali, Claudia

    1999-01-01

    Arheoloog Jean-Yves Empereur leidis Egiptuse Aleksandria linna lähedal asuvasse kaljusse rajatud katakombid, mis on osa hellenistlikul perioodil rajatud ning pikka aega unustuse hõlmas olnud surnute linnast. Leidude seas on kipsist Meduusa pea nind leide Rooma perioodist.

  11. Tunable deep ultraviolet femtosecond sum frequency laser based on Ba1-xB2-y-zO4SixAlyGaz crystal%Ba1-xB2-y-z O4SixAly Gaz晶体和频可调谐深紫外飞秒激光器∗

    Institute of Scientific and Technical Information of China (English)

    孟祥昊; 刘华刚; 黄见洪; 戴殊韬; 邓晶; 阮开明; 陈金明; 林文雄

    2015-01-01

    Tunable coherent deep ultraviolet (DUV) light sources, especially ultrashort pulse DUV lasers have great appli-cations in the fields of time-resolved, material processing, spectroscopy, laser spectroscopy and laser fusion. In the UV region, the best choice of generating the laser pulses in the femtosecond or picosecond regime is the frequency up-conversation technique based on second order nonlinearities. Over the past three decades, quite a lot of nonlinear crystals, such as LiB3O5, β-BaB2O4, KBe2BO3F2 and Ba1−xB2−y−zO4SixAlyGaz have been developed and employed for gener-ating the femtosecond pulses in the blue, ultraviolet, and even the deep-ultraviolet region. A tunable deep ultraviolet femtosecond laser is experimentally studied based on the new nonlinear crystal Ba1−xB2−y−zO4SixAlyGaz It is a kind of low-temperature phase barium metaborate single crystal belonging to a trigonal system, doped with one or more elements selected from Si, Al and Ga. As an optimized β-BaB2O4 crystal, Ba1−xB2−y−zO4SixAlyGaz completely overcomes the shortcomings of deliquescence compared withβ-BaB2O4, and its nonlinear efficiency and optical damage threshold have also been greatly improved. Using two crystals as second harmonic generation is to compensate for the spatial walk-off effect and the light path walk-off due to refraction effect The optical axis of the second Ba1−xB2−y−zO4SixAlyGaz is twice the phase matching angle with respect to the first one. In a femtosecond regime, short pulse provides high efficient frequency conversation due to their high peak powers, but the group velocity mismatch is a cognitive factor to limit conversion efficiency. It is obvious that after the frequency doubling, the second harmonic pulse and fundamental pulse separate from each other. The second harmonic pulse lags behind the fundamental pulse as they propagate through the crystal and the second harmonic pulse is broadened into a longer pulse duration than the

  12. Clinical significance of PCT in exhaled breath condensate and serum of patients with acute lung injury/acute respiratory distress syndrome%ALI/ARDS患者呼出气冷凝液和血清中PCT检测及其临床意义

    Institute of Scientific and Technical Information of China (English)

    陈金亮; 陈建荣; 薛垒喜; 陶一江; 陶国华

    2015-01-01

    目的:研究ALI/ARDS患者呼出气冷凝液( EBC)和血清中降钙素原( PCT)的变化规律,探讨PCT在ALI/ARDS诊断、病情评估、预后判断中的临床意义。方法选择行机械通气的ALI/ARDS患者33例;同时选择20例健康体检者为健康对照组。观察ALI/ARDS患者与健康对照组之间血清和EBC中PCT的差异,分析临床指标和各种指标之间的相关性。结果①ALI/ARDS组EBC和血清中PCT高于健康对照组。②ARDS组患者第七天EBC和血清中PCT中PCT高于ALI组。③存活组患者治疗后EBC和血清中PCT水平下降,病死组患者EBC和血清中PCT持续升高。④EBC和血清中PCT与PaO2/FiO2、APACHEⅡ有相关性。结论 ALI/ARDS患者EBC和血清中PCT的检测,有助于ALI/ARDS的诊断、病情评估和判断预后。%Objective To detect the change of procalcitonin ( PCT) in exhaled breath condensate ( EBC) and serum of ALI/ARDS patients and to explore its clinical significance in diagnosis, illness evaluation and progno-sis. Methods The study selected 33 mechanical ventilation patients with ALI/ARDS as the observation group and 20 healthy people as the control group. The difference of PCT in EBC and serum was compared between the two groups, and the correlation among the clinical indicators was analyzed. Results ①The level of PCT in EBC and se-rum was higher in the observation group than in the control group. ②The level of PCT was higher in the ARDS group than in the ALI group on the seventh day. ③The level of PCT decreased in the survival group after treatment, but it increased in the death group. ④ The level of PCT in EBC and serum was associated with PaO2/FiO2 and APACHE Ⅱ. Conclusion The test of PCT in EBC and serum of ALI/ARDS patients can contribute to their diagnosis, condi-tion evaluation and prognosis.

  13. Diffusion, diffraction des neutrons en temps réel et études réalisées in situ

    Science.gov (United States)

    Isnard, O.

    2003-02-01

    La diffusion des neutrons est une technique particulièrement efficace pour l'analyse en temps réel des processus réactionnels dans la matière. La diffraction de neutrons in situ a été développée très tôt sur les sources à haut flux tel que l'Institut Laue Langevin. Ces études nécessitent un flux de neutrons important et un détecteur couvrant un domaine angulaire le plus grand possible. Les neutrons offrent la spécificité d'être très peu absorbés par nombre de matériaux, cette faible absorption fait de la diffusion neutronique un excellent outil pour sonder la matière en volume et de manière non destructive. Cela permet en particulier d'utiliser des environnements d'échantillons complexes tout en conservant un flux raisonnable. La diffusion de neutrons en temps réel est donc très largement utilisée par diverses communautés scientifiques : sciences des matériaux, physiciens, chimistes... L'objet de ce cours est de donner les paramètres importants pour ce type d'étude et d'illustrer le propos à l'aide d'exemples pris dans des domaines scientifiques divers : électrochimie, magnétisme, métallurgie, chimie du solide. Après avoir présenté quelques repères méthodologiques sur les méthodes d'acquisition de données, des exemples montreront le fort potentiel de la diffusion neutronique en temps réel pour l'étude de la matière dans des conditions dynamiques. Enfin, nous donnerons aussi quelques conseils pour la visualisation, le dépouillement et l'analyse de ce type d'expérience. La diffusion des neutrons sur poudre est actuellement très bien adaptée aux études réalisées in situ. Cependant, nous verrons que la faisabilité d'études in situ s'étend à d'autres techniques expérimentales telles que la diffusion des neutrons aux petits angles et même la diffusion sur monocristal qui est en plein renouveau.

  14. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology.

    Science.gov (United States)

    Rehman, Shaheed Ur; Choe, Kevin; Yoo, Hye Hyun

    2016-03-10

    Eurycoma longifolia Jack (known as tongkat ali), a popular traditional herbal medicine, is a flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and also Cambodia, Myanmar, Laos and Thailand. E. longifolia, is one of the well-known folk medicines for aphrodisiac effects as well as intermittent fever (malaria) in Asia. Decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever. Mostly, the roots extract of E. longifolia are used as folk medicine for sexual dysfunction, aging, malaria, cancer, diabetes, anxiety, aches, constipation, exercise recovery, fever, increased energy, increased strength, leukemia, osteoporosis, stress, syphilis and glandular swelling. The roots are also used as an aphrodisiac, antibiotic, appetite stimulant and health supplement. The plant is reported to be rich in various classes of bioactive compounds such as quassinoids, canthin-6-one alkaloids, β-carboline alkaloids, triterpene tirucallane type, squalene derivatives and biphenyl neolignan, eurycolactone, laurycolactone, and eurycomalactone, and bioactive steroids. Among these phytoconstituents, quassinoids account for a major portion of the E. longifolia root phytochemicals. An acute toxicity study has found that the oral Lethal Dose 50 (LD50) of the alcoholic extract of E. longifolia in mice is between 1500-2000 mg/kg, while the oral LD50 of the aqueous extract form is more than 3000 mg/kg. Liver and renal function tests showed no adverse changes at normal daily dose and chronic use of E. longifolia. Based on established literature on health benefits of E. longifolia, it is important to focus attention on its more active constituents and the constituents' identification, determination, further development and most importantly, the

  15. Evaluation of radiologic findings in neonates with hirschprung's disease, referred to Boo-Ali Sina Hospital in Sari between 2008 and 2009

    Directory of Open Access Journals (Sweden)

    Abdolrasoul Alaee

    2009-01-01

    Full Text Available (Received 9 September, 2009 ; Accepted 9 November, 2009AbstractBackground and purpose: Diagnosis of Hirschprung's disease is one of the most important problems of pediatric surgeons and leaving it without treatment has its own complications. Early diagnosis in younger age with special attention to clinical and radiological findings can reduce these complications. The aim of this study was to compare the findings of plain abdominal radiography and contrast enema in neonates with Hirschprung's disease.Materials and methods: Twenty seven neonates referred to Boo-Ali Sina Hospital, in Sari (2007-2009 for Hirschprung's disease underwent abdominal X-ray and barium enema, and the findings were evaluated followed by rectal biopsy was. In all cases, radiological and barium enema findings were seen by a radiologist, and in each view presence of serration in colon, distention of colon, absence of gas in colon, small intestinal distention, soap bubble and mottling in RLQ of abdomen, delay on barium transit, recto-sigmoid index, absence or present of TZ (Transitional Zone were assessed. Data were analyzed using SPSS 16 software. Chi-Square test and descriptive statistical methods were used for comparing abdominal X-ray and barium enema effectiveness for differentiating patients with Hirschprung's disease.Results: The findings in plain abdominal radiography were: colonic distention and TZ (82.59%, absence of gas in rectum (48.15%, small bowel distention (7.41%, soap bubble pattern (3.7% and mottling in RLQ (3.7%. In contrast the findings of enema of neonates were: distention (70.3%, delayed barium transition (59.2%, transitional zone (55.5%, barium-fecal mixing (22.2%, micro colon (7.4% and serration (3.7%.Conclusion: A plain abdominal radiography is reliable and useful in diagnosis of the disease in patients with failed contrast enema. Key words: Hirschprung's disease, neonate, plain abdominal radiography and contrast enema J Mazand Univ Med Sci 2009; 20

  16. Le champ critique de claquage de films d'oxyde de polyphénylène réalisés par voie électrochimique

    Science.gov (United States)

    Adohi, B.; Gosse, J. P.; Gosse, B.

    1991-10-01

    The electrical breakdown of thin films of polyphenylene oxide electrochemically deposited on stainless steel plane substrates has been studied. First it was examined the dependence of the medium surrounding the dielectric and the electrodes (nature, hydrostatic pressure) on the breakdown voltage and on its statistical distribution. Between sphere and plane electrodes, it appears that even for pressurified gases, breakdown of the film is caused by the gas breakdown. We have analysed the discharges occurring at atmosphere pressure in the test cell. Breakdown of the film occurred when the electric field due to the charge deposited on its surface was about 230 V/μm. We have also studied self-healing capacitors with PPO as a dielectric, and determined the life-time of this material. On a étudié le claquage électrique de films minces d'oxyde de polyphénylène de quelques microns d'épaisseur déposés par voie électrochimique sur un plan en acier inoxydable. L'étude a d'abord été faite en rampe de tension continue dans la géométrie d'électrodes sphèreplan, en fonction du milieu ambiant liquide ou gazeux. L'influence de la pression sur la rigidité diélectrique du matériau, les distributions statistiques de Weibull et les cratères formés au moment du claquage, dans les différents milieux et dans les deux polarités de l'électrode sphérique montrent que le claquage du matériau est causé par des décharges qui se produisent dans le milieu environnant. A partir de l'analyse quantitative de ces décharges, on propose comme critère de caractérisation de la rupture d'un matériau sounmis aux décharges, le champ créé au moment de la rupture par les charges déposées à sa surface. On a réalisé ensuite des échantillons plans > par dépôt de couches minces d'aluminium (quelques milliers d'Å d'épaisseur) sur le film de PPO. On étudie dans cette configuration la durée de vie du matériau.

  17. Centennial-scale vegetation and climate changes in the Middle Atlas, Morocco: new insights from multi-proxy investigations at Lake Sidi Ali

    Science.gov (United States)

    Fletcher, William; Campbell, Jennifer; Joannin, Sebastien; Mischke, Steffen; Zielhofer, Christoph; de Batist, Marc; Mikdad, Abdes

    2016-04-01

    The karstic lakes of the Middle Atlas, Morocco, represent a valuable archive of environmental and climatic change for Northwest Africa. Here we present the results of centennial-scale palynological and charcoal analyses as part of a multiproxy palaeolimnological study of sediment cores from Lake Sidi Ali in the Middle Atlas, Morocco (33° 03 N, 05° 00 W; 2,080 m a.s.l.). Supported by absolute dating including 23 more than twenty AMS 14C dates on pollen concentrates, the record covers the entire Holocene and offers insights into vegetation and climate change at a regionally unprecedented centennial-scale. Pollen assemblages are dominated by steppic herbs, evergreen oaks (Quercus), junipers (Cupressaceae) and Atlantic cedar (Cedrus atlantica). A long-term evolution of the montane vegetation is recorded, reflecting progressive changes in the dominant arboreal taxa and leading to the full establishment of the emblematic cedar forests of the area during the mid-Holocene by 6000 cal BP. Orbital-scale changes in seasonality and growing season moisture availability linked to declining summer insolation are implicated, with a transition from (a) warm, dry summers associated with summer drought tolerant taxa especially evergreen Quercus, high algal productivity in the lake, and high background levels of microcharcoal reflecting distant fire activity during the early Holocene, to (b) cool, relatively humid summers with dominance of montane conifers, declining algal productivity in the lake, and episodic local fire activity during the mid- to late Holocene. Superimposed on the long-term environmental changes are recurrent centennial-scale fluctuations in vegetation composition, reflecting competitive dynamics between the major taxa, initially between steppic and arboreal elements, and later between the major tree taxa. Parallels with hydrological proxies including stable O and C isotopes suggest common responses to climatic drivers (fluctuations in moisture sources and

  18. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali: Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology

    Directory of Open Access Journals (Sweden)

    Shaheed Ur Rehman

    2016-03-01

    Full Text Available Eurycoma longifolia Jack (known as tongkat ali, a popular traditional herbal medicine, is a flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and also Cambodia, Myanmar, Laos and Thailand. E. longifolia, is one of the well-known folk medicines for aphrodisiac effects as well as intermittent fever (malaria in Asia. Decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever. Mostly, the roots extract of E. longifolia are used as folk medicine for sexual dysfunction, aging, malaria, cancer, diabetes, anxiety, aches, constipation, exercise recovery, fever, increased energy, increased strength, leukemia, osteoporosis, stress, syphilis and glandular swelling. The roots are also used as an aphrodisiac, antibiotic, appetite stimulant and health supplement. The plant is reported to be rich in various classes of bioactive compounds such as quassinoids, canthin-6-one alkaloids, β-carboline alkaloids, triterpene tirucallane type, squalene derivatives and biphenyl neolignan, eurycolactone, laurycolactone, and eurycomalactone, and bioactive steroids. Among these phytoconstituents, quassinoids account for a major portion of the E. longifolia root phytochemicals. An acute toxicity study has found that the oral Lethal Dose 50 (LD50 of the alcoholic extract of E. longifolia in mice is between 1500–2000 mg/kg, while the oral LD50 of the aqueous extract form is more than 3000 mg/kg. Liver and renal function tests showed no adverse changes at normal daily dose and chronic use of E. longifolia. Based on established literature on health benefits of E. longifolia, it is important to focus attention on its more active constituents and the constituents’ identification, determination, further development and most

  19. Spectroscopic Characterization of GaAs and AlxGa1 – xAs / AlyGa1 – yAs Quantum Well Heterostructures

    Directory of Open Access Journals (Sweden)

    Mirgender Kumar

    2013-07-01

    Full Text Available This work presents the results of the characterization of GaAs and AlxGa1 – xAs / AlyGa1 – yAs quantum well hetero-structures growth by MOVPE system. The main goal is to explore the ability of characterization techniques for multilayer structures like quantum wells. The characterization was performed using photoreflectance spectroscopy, surface photovoltaic spectroscopy and X-ray diffraction. The experimental results are verified by numerical simulation.

  20. Mémoire et imagination chez les aliénistes esquiroliens et dans la troisième version de la Tentation de saint-Antoine de Flaubert : d’un savoir l’autre

    Directory of Open Access Journals (Sweden)

    Jean-Louis Cabanès

    2011-01-01

    Full Text Available A la suite d’Esquirol dans son traité Des maladies mentales de 1838, ceux que l’on appelait alors les « aliénistes » proposent de nouvelles théories de l’imagination qui, considérées dans leur ensemble, esquissent un cadre épistémique que Flaubert utilise comme cadre rhétorique dans la troisième version de la Tentation de saint-Antoine. Toutefois, l’auteur n’accepte pas l’assimilation de l’état dans lequel se trouve l’artiste lorsqu’il crée à une hallucination pathologique. Il s’oppose en cela à la théorie de Moreau de Tours ; en revanche, il se montre plus proche de la pensée de Brierre de Boismont (et de celle de l’historien Alfred Maury. Par cet usage intelligemment mitigé du cadre épistémique de l’aliénisme contemporain et par l’invention d’une prose poétique dont les soubassements théoriques annoncent certaines conceptions de Freud et de Nietzsche, Flaubert dépasse résolument les esquiroliens.

  1. Palaeomagnetism and K-Ar and 40Ar/39Ar ages in the Ali Sabieh area (Republic of Djibouti and Ethiopia): constraints on the mechanism of Aden ridge propagation into southeastern Afar during the last 10 Myr

    Science.gov (United States)

    Audin, L.; Quidelleur, X.; Coulié, E.; Courtillot, V.; Gilder, S.; Manighetti, I.; Gillot, P.-Y.; Tapponnier, P.; Kidane, T.

    2004-07-01

    A new detailed palaeomagnetic study of Tertiary volcanics, including extensive K-Ar and 40Ar/39Ar dating, helps constrain the deformation mechanisms related to the opening processes of the Afar depression (Ethiopia and Djibouti). Much of the Afar depression is bounded by 30 Myr old flood basalts and floored by the ca 2 Myr old Stratoid basalts, and evidence for pre-2 Ma deformation processes is accessible only on its borders. K-Ar and 40Ar/39Ar dating of several mineral phases from rhyolitic samples from the Ali Sabieh block shows indistinguishable ages around 20 Myr. These ages can be linked to separation of this block in relation to continental breakup. Different amounts of rotation are found to the north and south of the Holhol fault zone, which cuts across the northern part of the Ali Sabieh block. The southern domain did not record any rotation for the last 8 Myr, whereas the northern domain experienced approximately 12 +/- 9° of clockwise rotation. We propose to link this rotation to the counter-clockwise rotation observed in the Danakil block since 7 Ma. This provides new constraints on the early phases of rifting and opening of the southern Afar depression in connection with the propagation of the Aden ridge. A kinematic model of propagation and transfer of extension within southern Afar is proposed, with particular emphasis on the previously poorly-known period from 10 to 4 Ma.

  2. Luminescent properties of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} and its luminescence improvement by incorporating A{sup +} (A=Li, Na, and K)

    Energy Technology Data Exchange (ETDEWEB)

    Li, Panlai, E-mail: li_panlai@126.com; Wang, Zhijun, E-mail: wangzj1998@126.com; Yang, Zhiping; Guo, Qinglin

    2014-12-15

    A novel green phosphor SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} is synthesized by a high temperature solid-state method, and its luminescent property is investigated. X-ray diffraction patterns of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} indicate a similarity crystalline phase to SrZn{sub 2}(PO{sub 4}){sub 2}. SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} shows green emission under 369 nm excitation, and the prominent luminescence in green (544 nm) due to {sup 5}D{sub 4}–{sup 7}F{sub 5} transition of Tb{sup 3+}. For the 544 nm emission, excitation spectrum has several excitation band from 200 nm to 400 nm. Emission intensity of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} is influenced by Tb{sup 3+} concentration, and concentration quenching effect of Tb{sup 3+} in SrZn{sub 2}(PO{sub 4}){sub 2} is also observed. With incorporating A{sup +} (A=Li, Na, and K) as compensator charge, the emission intensity of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} can be obviously enhanced. CIE color coordinates of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} locate in the green region. The results indicate this phosphor may be a potential application in white LEDs. - Graphical abstract: SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} can produce green emission under near-UV excitation, and its luminescent properties can be improved by incorporating A{sup +} (A=Li, Na, and K). - Highlights: • SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} can produce green emission under near-UV excitation. • Concentration quenching effect of Tb{sup 3+} in SrZn{sub 2}(PO{sub 4}){sub 2} is observed. • Emission intensities of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} are enhanced by codoped A{sup +} (A=Li, Na, K)

  3. Hasan Ali Toptaş'ın Kayıp Hayaller Kitabı'nda Büyülü Gerçekçilik In Kayıp Hayaller Kitabı of Hasan Ali Toptaş Megical Realism

    Directory of Open Access Journals (Sweden)

    Oktay YİVLİ

    2013-09-01

    Full Text Available In narrations of magical reality, real and unreal, ordinary andextraordinary, authentic and imaginary elements exist together withoutany conflict. Magical Realism flourishes especially in the twentiethcentury Latin American Literature. This sense results from the struggleof comprehending and narrating new reality as opposed to fantasticfictions and tales. In his novel called Kayıp Hayaller Kitabı, Hasan AliToptaş included the techniques and elements used in the samples ofmagical realism, such as de-familiarization, singularity, indefiniteness,dead people and multiple narrators.As be different fantastic in magical realism fictional people havebeen to become inured to in a world which is together realty and magic,just about accepted it as a natural media. Formal notice of magicalrealism from fantastic is that it selects spaces from realty world notimaginary world.In his novel called Kayıp Hayaller Kitabı, external reality isn’talways reflected one to one. The narration differentiates from classicnarrative structure reality in terms of presentations. Event descriptionsseen, heard and dreamed are presented in an imaginary order. In thenovel, the nature of entities and objects are given as changed Thus ittries to catch to catch another dimension of reality. The people in thenovel doubt from their own realities. What is real, what is not realbecome confused.After all these features, the novel studied should be considered asa magical realistic novel and should be evaluated as use aesthetics ofmagical realism. Büyülü gerçekçi anlatılarda gerçekle gerçek dışı, olağanla olağan olmayan, düşsel ile sahici ögeler aynı dünyanın içinde herhangi bir çatışmaya girmeden yaşarlar. Büyülü gerçekçilik özellikle yirminci yüzyıl Latin Amerikan edebiyatında gelişip serpilmiştir. Bu anlayış fantastikten ve masaldan ayrı olarak yeni gerçekliği kavramanın ve anlatmanın bir çabası olarak ortaya çıkmıştır. Hasan Ali

  4. ALI/ARDS患者呼出气冷凝液中H2O2检测的临床意义%Detection in exhaled breath condensate of patients with acute lung injury/acute respiratory distress syndrome

    Institute of Scientific and Technical Information of China (English)

    邢佳丽; 陈建荣; 陈金亮; 蒋云书; 徐志华; 陶国华; 陶一江

    2012-01-01

    目的 研究急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)患者呼出气冷凝液(EBC)中过氧化氢(H2O2)浓度的临床意义.方法 32例ICU中行机械通气的ALI/ARDS患者为研究组,采用改进的EcoScreen呼出气冷凝液收集器收集患者第1天和第5天的EBC标本.24例健康体检者为对照组,自主呼吸收集EBC.全部对象同步抽取静脉血离心留取血清.用ELISA法测定EBC和血清中的H2O2浓度.动态观察不同分组对象EBC和血清中H2O2的差异,并进行临床指标的相关性分析.结果 ①ALI/ARDS患者EBC-H2O2水平(187.19±25.94)nmol/mL高于健康对照组(95.25±21.15)nmol/mL(P2.5组(201.08±22.50)nmol/mL高于LIS≤2.5组(180.88±25.35)nmol/mL(P<0.05),第5天EBC-H2O2水平LIS>2.5组(158.41±29.45)nmol/mL高于LIS≤2.5组(123.40±26.15)nmol/mL(P<0.01);④第5天EBC- H2O2水平病死组(150.97±32.33)nmol/mL高于存活组(125.63±27.85)nmol/mL(P<0.05);⑤EBC和血清中H2O2均与A-a DO2、LIS值、X片、PEEP、MEWS评分呈正相关,与PaO2、PaO2/FiO2、PaO2/PAO2呈负相关,EBC-H2O2与肺顺应性呈负相关.结论 检测EBC中H2O2水平的变化可反映ALI/ARDS患者肺部存在氧化应激、炎症反应,可作为ALI诊断的辅助指标之一,且在评估肺损伤的严重程度、评价治疗效果和估计预后方面优于血清H2O2检测.

  5. Participation du patient Marocain atteint du cancer au choix thérapeutique: résultat d'une enquête réalisée auprès de 272 patient

    OpenAIRE

    Boukir, Anwar; Azghari, Ilham; El Kabous, Mustapha; Jouid, Khalid; Boutayeb, Saber; El Ghissassi, Ibrahim; Mrabti, Hind; Errrihani, Hassan

    2015-01-01

    Introduction La décision médicale partagée ‘Shared decision making’ est un concept qui se développe depuis les années 1990. Il donne aux patients le soutien nécessaire pour exprimer leurs préférences et partager la décision médicale. Cette étude cherche à estimer le degré de participation du patient Marocain atteint de cancer au choix thérapeutique. Méthodes Cette enquête a été réalisée auprès de 272 malades sous chimiothérapie pour une pathologie cancéreuse sous forme d'un entretien verbal b...

  6. İslam Dünyasının İlk Tıp Ansiklopedisi Firdevsü'l-Hikme ve Müellifi ?Ali b. Sehl Rabban Taberi: Hayatı ve Eserleri

    Directory of Open Access Journals (Sweden)

    Salim Aydüz

    2013-01-01

    Full Text Available As a physician, scientist and philosopher, ‘Alī b. Sahl Rabbān al-Ṭabarī was the son of Sahl Sahl Rabbān al-Ṭabarī. ‘Ali was born in the educated and intellectual Christian family. He wrote many books on philosophy, medicine and religious matters. Particularly, his Firdaws al-ḥikma is the first ever written medical encyclopaedia which incorporates all the branches of the medical sciences. This article demonstrates how important ‘Alī b. Sahl al-Ṭabarī’s contribution was significant in Muslim heritage in terms of philosophical, religious and medicinal works. A rich bibliography backs the arguments of the articles and provides a solid basis for further reading.

  7. Retraction: "Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer" by Ali et al.

    Science.gov (United States)

    2016-08-01

    The above article, published online on March 8, 2010 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figures 2A, 4, 6A, and 6C to be inappropriately manipulated. REFERENCE Ali S, Banerjee S, Schaffert JM, El-Rayes BF, Philip PA, Sarkar FH. 2010. Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer. J Cell Biochem 110:171-181; doi: 10.1002/jcb.22523.

  8. Retraction: "Inactivation of Ink4a/Arf Leads to Deregulated Expression of miRNAs in K-Ras Transgenic Mouse Model of Pancreatic Cancer" by Ali et al.

    Science.gov (United States)

    2016-10-01

    The above article, published online on June 21, 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figure 5A to be inappropriately manipulated. Literature Cited Ali S, Banerjee S, Logna F, Bao B, Philip PA, Korc M, Sarkar FH. 2012. Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer. J Cell Physiol 227:3373-3380; doi: 10.1002/jcp.24036.

  9. Baudžiamoji atsakomybė už plėšimą pagal Lietuvos Respublikos ir užsienio šalių baudžiamuosius įstatymus

    OpenAIRE

    Klanauskienė, Asta

    2009-01-01

    Baudžiamoji atsakomybė už plėšimą pagal Lietuvos Respublikos ir užsienio šalių baudžiamuosius įstatymus SANTRAUKA Nepaisant griežtos teisinės apsaugos didžiąją dalį visų nusikalstamų veikų sudaro nusikalstamos veikos nuosavybei. Plėšimas pagal savo pavojingumo laipsnį priskiriamas pavojingiausiems nusikaltimams nuosavybei. Tinkamas baudžiamųjų įstatymų taikymas, teisingas šių nusikaltimų kvalifikavimas bei teisingas bausmių skyrimas už padarytas nusikalstamas veikas buvo ir išlieka viena svar...

  10. Hz. Ali’nin Menkıbevî Hayatına Dair Bir Destan: Dâstân-ı Ejderhâ A Legend about the life of Ali: The Legend of Dragon

    Directory of Open Access Journals (Sweden)

    Ali KOZAN

    2013-07-01

    Full Text Available Following the conversion of Turks to Islam a new structure ofbelief and culture has appeared for them. They recall the individualsthey consubstantiated with Islam by heroic stories in verbal custom. Inthis praxis especially the son in law of Prophet Muhammed, first fourCaliphs and the friends of Prophet have become indispensable part ofthese legendary stories. In the legendary stories which our workincludes, the heroic, warrior and courageous side of Ali have shown asbeing a son in law of Prophet and father of Hasan and Hussein.Thistradition has written down by the works of Islamic Era of TurkishHistory. One of the “Cenknâmes” which Ali's braveness and courageoushas mention is “Destan-ı Ejderha”, The Legend Of Dragon. The legendhas written in the manner of "masnavi" and also it has some features oftale and legend genre.In this work namely “Destan-ı Ejderha” a dragon which Muslimscame to place of Prophet Muhammed in order to complain of it and awar which was fought between dragon and a group of “sahabe” underthe leadership of Ali by the assignment of Prophet Muhammed and thedefeat of dragon were mentioned. At the work Ali combines fantasticpowers in his heroic personality therefore withstands against dragonwhich was symbolized as an enemy of the religion and Ali has apersonality that is not avoid to struggle. In the legend Muslims wereaimed to encourage to “gaza” by underlining Ali’s face up of the death.Also it is aimed to obtain an idea that the true religion is Islam and alsoto make the ideal of gaza and jihad by the pointing the rebellious oneswill be eradicated in a pathetic way.In our work primarily we have compared the copies by collectedthe exemplars of “The Legend of Dragon” then tried to expose theoriginal text. Epic’s implications are discussed in Anatolia and theBalkans, later on an assessment is made about the value and place ofthe mentioned pamphlet in the history of Turkish Culture in Islamicperiod

  11. Application of multivariate statistical analysis and hydrochemical and isotopic investigations for evaluation of groundwater quality and its suitability for drinking and agriculture purposes: case of Oum Ali-Thelepte aquifer, central Tunisia.

    Science.gov (United States)

    Hassen, Imen; Hamzaoui-Azaza, Fadoua; Bouhlila, Rachida

    2016-03-01

    Groundwater plays a dominant role in arid regions; it is among the most available water resources in Tunisia. Located in northwestern Tunisia, Oum Ali-Thelepte is a deep Miocene sedimentary aquifer, where groundwater is the most important source of water supply. The aim of the study is to investigate the hydrochemical processes leading to mineralization and to assess water quality with respect to agriculture and drinking for a better management of groundwater resources. To achieve such objectives, water analysis was carried out on 16 groundwater samples collected during January-February 2014. Stable isotopes and 26 hydrochemical parameters were examined. The interpretation of these analytical data showed that the concentrations of major and trace elements were within the permissible level for human use. The distribution of mineral processes in this aquifer was identified using conventional classification techniques, suggesting that the water facies gradually changes from Ca-HCO3 to Mg-SO4 type and are controlled by water-rock interaction. These results were endorsed using multivariate statistical methods such as principal component analysis and cluster analysis. The sustainability of groundwater for drinking and irrigation was assessed based on the water quality index (WQI) and on Wilcox and Richards's diagrams. This aquifer has been classified as "excellent water" serving good irrigation in the area. As for the stable isotope, the measurements showed that groundwater samples lay between global meteoric water line (GMWL) and LMWL; hence, this arrangement signifies that the recharge of the Oum Ali-Thelepte aquifer is ensured by rainwater infiltration through mountains in the border of the aquifer without evaporation effects.

  12. 27 August 2013 - Signature of an Agreement between KTO Karatay University in Turkey represented by the Dean of Engineering Professor Ali Okatan, CERN represented by Director for Research and Computing Dr Sergio Bertolucci and ALICE Collaboration represented by ALICE Collaboration Spokesperson Dr Paolo Giubellino.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    27 August 2013 - Signature of an Agreement between KTO Karatay University in Turkey represented by the Dean of Engineering Professor Ali Okatan, CERN represented by Director for Research and Computing Dr Sergio Bertolucci and ALICE Collaboration represented by ALICE Collaboration Spokesperson Dr Paolo Giubellino.

  13. Le diagnostic anténatal de la trisomie 21 par l'hybridation in situ en fluorescence (FISH): à propos des premiers tests réalisés au Maroc

    Science.gov (United States)

    Lamzouri, Afaf; Natiq, Abdelhafid; Tajir, Mariam; Sendid, Mohamed; Sefiani, Abdelaziz

    2012-01-01

    Introduction Le but de cette étude était de présenter les premiers résultats de diagnostic anténatal de la trisomie 21 par la technique d'hybridation in situ en fluorescence (FISH) au Maroc et discuter son intérêt dans le diagnostic rapide de cette aneuploïdie. Méthodes Ce travail a été réalisé chez 23 femmes avec des grossesses à haut risque de trisomie 21. La moyenne d’âge des gestantes étaient de 37,43 ans avec des extrêmes de 21 et 43 ans. Toutes étaient musulmanes mariées, mariage légitimé par la Charia, dont trois mariages consanguins, sauf une originaire de la République Démocratique du Congo qui était chrétienne et concubine. La majorité des femmes étaient fonctionnaires et avaient un niveau de scolarisation moyen à élevé. Toutes les patientes ont bénéficié d'une consultation de génétique médicale au cours de laquelle il leur a été donné des informations sur la technique, son intérêt et ses limites. Il s'agit de femmes enceintes qui avaient soit un âge maternel élevé ou des signes d'appel échographiques et/ ou biochimiques. Une des patientes était porteuse d'une translocation robertsonienne t(14;21) équilibrée. Une amniocentèse a été réalisée chez toutes les gestantes et aucun avortement n'a était induit par ce geste invasif. L’âge gestationnel moyen à la première consultation était de 14 semaines d'aménorrhée (SA) et à l'amniocentèse était de 16 SA et 5 jours. L'analyse FISH a été réalisée, après consentement des couples, sur des cellules non cultivées à partir des échantillons de liquides amniotiques, en utilisant des sondes spécifiques du chromosome 21. Résultats Parmi les 23 patientes qui ont bénéficiées d'un diagnostic anténatal de la trisomie 21 par la technique FISH, nous avons pu rassurer 21 d'entre elles, et nous avons détecté deux cas de trisomie 21 fœtal. Conclusion La technique FISH permet un diagnostic anténatal rapide, en moins de 48h, de la trisomie 21 sur

  14. İSMAİL BEY GASPIRALI’NIN ALİ MERDAN TOPÇUBAŞI’NA YAZDIĞI MEKTUPLAR / THE LETTERS WRITTEN BY ISMAIL BEY GASPRINSKIJ TO ALI MERDAN BEY TOPCHUBASHI

    Directory of Open Access Journals (Sweden)

    Rıdvan ÇİTİL

    2015-09-01

    Full Text Available Rusya Müslümanları-Türkleri hakkında bilinmeyenler, araştırmacılar arasında her geçen gün daha çok merak uyandırmaktadır. Bu konuda, yeni belgeler gün yüzüne çıkmakta ve birçok çalışmalar yapılmaktadır. Bu makalemizde 1904-1910 yılları arasında cereyan eden siyasî, kültürel vb. olayları o dönemin en önde gelen aydın, lider ve maarifçilerinden biri olan İsmail Bey Gaspıralı’nın Azerbaycanlı avukat, yazar, gazeteci ve siyaset adamı Ali Merdan Topçubaşı’na yazdığı yedi adet mektuptan takip etme imkânını bulacağız. Böylece o dönemle ilgili en ince ayrıntıları yakalamış ve bazı bilinmeyenleri birinci ağızdan öğrenmiş olacağız. / Unknowns about Russian Muslims-Turks day by day become more and more curious. In this issues, appear new documents and studies are carried out. When it comes to correspondence of Ismail Gasprinski and other intellectuals and the author of the Turkic World the importance of these documents rises one more time. In this study we will have possibility to follow up the political, cultural and so on events that took place between the years 1904-1910, from seven letters whom write one of the leading intellectuals of the authority of that era, one of the leaders and educator Ismail Bey Gasprinski to Azerbaijani lawyer, author, journalist Ali Merdan Topçubashi. So we caught the finest details about that period and will learn unknowns from the first person.

  15. Assessment of the prevalence of refractive eye error and IOP during pregnancy and after delivery in patients referred to ophthalmology clinic of Boo-Ali Hospital of Qazvin in 1387

    Directory of Open Access Journals (Sweden)

    Mohammad Khalaj

    2009-01-01

    Full Text Available (Received 30 Jan 2010, 2010 ; Accepted 25 April, 2010AbstractBackground and purpose: Many pregnant women some of whom also suffer from refractive errors and use eyeglasses attend eye clinics The aim of this study was to assess the prevalence of refractive eye errors and changes in IOP, during pregnancy and after delivery among patients referred to ophthalmology clinic of Boo-Ali Hospital of Qazvin.Materials and methods: The study was conducted at eye clinic of Boo-Ali Hospital in Gazvin- Iran. A total of 150 pregnant women aged 17 to 38 years (mean 24.76 ± 4.61 were treated by ophthalmologist in three stages (16- and 32- week of pregnancy and 4 months after childbirth. Initially, all pregnant women were visited by a gynecologist and then they were referred to the ophthalmology clinic. The visual acuity was determined using chart Snellen from a distance of 6m and then refractive errors were measured by static retinoscopy and autorefractometer. Intraocular pressure was measured using air-puls noncontact tonometer in three stages.Results: In the first stage (16-week of pregnancy, hyperopia was seen in 12 patients (%8, myopia in 104 patients (%69.3, astigmatism in 26 patients (%17.3 and 8 patients (%5.3 were normal. The results of the second stage (32-week of pregnancy showed that 3 patients (%2 were hyperopia, 143 patients (%95 myopia, 2 patients (%1.3 astigmatism and 2 patients (%1.3 were normal. Four months after childbirth, 5 patients (%3.3 were hyperopia, 129 patients (%86 myopia, 13 patients (%13.7 astigmatism and 3 patients (%2 normal. The estimated relative risk of myopia was increased significantly in the second stage. The patients' IOP in the first stage was higher than the second stage and this difference was statistically significant (P<0.05.Conclusion: The results of this research showed that there is a significant relationship between pregnancy and myopia. IOP was reduced during pregnancy and return to the normal level after delivery

  16. “外贸英语函电”教学模式:基于速卖通创业实践%"Business English Correspondence" Teaching Model Based on AliExpress Entrepreneurial Practice

    Institute of Scientific and Technical Information of China (English)

    张丽

    2016-01-01

    Business English correspondence is one of the import-ant tools to carry out foreign trade business and business-related activities. Aiming at the disjointed Business Correspondence Teaching with English Language Teaching and Professional Skills Training, this paper explores how to combine with the need of the society, how to reform teaching models, and how to develop students' entrepreneur capacity, putting forward the idea of incorporating AliExpress entrepreneurial activities into classes to strengthen practice.%外贸英语函电是开展国际贸易业务和涉外商务活动的重要工具之一。针对当下外贸英语函电教学存在英语语言教学与专业技能培养严重的脱钩问题,文章将对该课程教学如何结合社会需求,如何改革教学模式,如何培养学生创业能力进行一些探究和思索,提出通过将速卖通创业实践有机地融入课堂,以加强教学中的实践。

  17. VUV spectroscopic properties of rare-earth (RE=Eu, Tb and Dy)-doped A2Zr(PO4)2 (A=Li, Na and K) phosphates

    Institute of Scientific and Technical Information of China (English)

    林啸; 冯昂; 张志军; 赵景泰

    2014-01-01

    This study fully investigated the vacuum ultraviolet excitation spectra of pure and rare-earth (RE=Eu, Tb and Dy)-doped A2Zr(PO4)2 (A=Li, Na and K) phosphors. The synthesized Na and Li compounds were characterized by XRD showing two new types of phases after indexation. Although these three pure compounds had different crystal structures, they exhibited similar luminescence properties. For Eu3+-activated samples, the broad excitation band centered at 217 nm could be attributed to the CT transition between O2- (2p6) and Eu3+ ions. For Tb3+-doped samples, two groups of f-d transitions were observed, where a strong broad band at 221 nm was due to the spin-allowed f-d transition. Energy transfer from O2-to Dy3+was not observed in Dy3+-doped phosphors, probably because it overlapped considerably with the CT transition from O2- to Zr4+at 187 nm.

  18. Cross-calibration of the Terra MODIS, Landsat 7 ETM+ and EO-1 ALI sensors using near-simultaneous surface observation over the Railroad Valley Playa, Nevada, test site

    Science.gov (United States)

    Chander, G.; Angal, A.; Choi, T.; Meyer, D.J.; Xiong, X.; Teillet, P.M.

    2007-01-01

    A cross-calibration methodology has been developed using coincident image pairs from the Terra Moderate Resolution Imaging Spectroradiometer (MODIS), the Landsat 7 (L7) Enhanced Thematic Mapper Plus (ETM+) and the Earth Observing EO-1 Advanced Land Imager (ALI) to verify the absolute radiometric calibration accuracy of these sensors with respect to each other. To quantify the effects due to different spectral responses, the Relative Spectral Responses (RSR) of these sensors were studied and compared by developing a set of "figures-of-merit." Seven cloud-free scenes collected over the Railroad Valley Playa, Nevada (RVPN), test site were used to conduct the cross-calibration study. This cross-calibration approach was based on image statistics from near-simultaneous observations made by different satellite sensors. Homogeneous regions of interest (ROI) were selected in the image pairs, and the mean target statistics were converted to absolute units of at-sensor reflectance. Using these reflectances, a set of cross-calibration equations were developed giving a relative gain and bias between the sensor pair.

  19. Siserände rahvuserinevused / Alis Tammur

    Index Scriptorium Estoniae

    Tammur, Alis

    2003-01-01

    Uuringu tulemustest selgus, et eestlaste rändeaktiivsus oli 1990. aastatel oluliselt suurem kui mitte-eestlastel. Kui eestlaste rändes valitses linnastumine, siis mitte-eestlaste vastulinnastumine on uus protsess ja näitab, et nende asustusala on Eestis laienemas. Tabelid. Diagramm. Kaardid

  20. A LSMA-based Comparison of the Performances in Retrieving Impervious Surface Between Landsat ETM+ and EO-1 ALI%不同传感器线性光谱分解反演不透水面的对比——以Landsat ETM+和EO-1 ALI为例

    Institute of Scientific and Technical Information of China (English)

    唐菲; 徐涵秋

    2013-01-01

    利用线性光谱分解模型,对同日过境的Landsat ETM+和EO-1 ALI影像的不透水面信息反演结果进行对比研究,从提取精度、盖度精度两方面对两种传感器影像的不透水面反演能力进行对比.结果表明,ALl反演不透水面的能力优于ETM+,其提取总精度和Kappa系数均高于ETM+高;其均方根误差和系统误差的绝对值都小于ETM+.两者产生差异的原因在于ALI的光谱分辨率和辐射分辨率均高于ETM+.%The extraction of impervious surfaces from satellite imagery has been a hot topic in the remote sensing field over the past decade.Nevertheless,whether the impervious surface information extracted from different sensor images is comparable is still unknown.This paper implemented a complementary study based on a comparison of the retrieved impervious surface information from Landsat ETM+-and EO-1 ALI sensor data.Impervious surface features were derived from a date-coincident image pair of the two sensors by using linear spectral mixture analysis (LSMA).The accuracy of retrieved impervious surface information of the two sensors was assessed and compared.The results show that the ALI image has higher accuracy than ETM+,as suggested by its higher overall accuracy and Kappa coefficient and lower root mean square error and systematic error (in absolute value).The differences in spectral resolution and radiometric resolution between the two sensors are believed to be the main factors causing these differences when retrieving impervious surfaces.An increase in spectral information in ALI sensor can be of help when distinguishing differences between land cover types,while the enhancement in radiometric resolution in the ALI sensor can make the sensor more sensitivite when detecting ground surface features.

  1. Etude expérimentale et théorique d'un transistor à flux de vortex réalisé sur couche mince supraconductrice à haute Tc. Comparaison avec un interféromètre haut Tc à boucles multiples

    OpenAIRE

    Flament, Stéphane; Dubuc, C; Lam Chok Sing, Marc; Bloyet, Daniel; Bernstein, P.; Hamet, J.; Blanc Guilhon, B.; Desfeux, R.

    1994-01-01

    Nous présentons une étude expérimentale et théorique de structures supraconductrices réalisées sur couches minces d'YBaCuO (déposées sur substrat de MgO) commandées en champ magnétique basées, l'une sur le mouvement de vortex Abrikosov, l'autre sur les interférences des fonctions d'onde des paires de Cooper traversant des jonctions Josephson HTc connectées en parallèle.

  2. Elaboration par procédé sol-gel de fluorures de type ALnF4 (A=Li, Na et Ln=Y, Gd) et de composites SiO2/LiGdF4 dopés par les ions de terres rares pour applications optiques

    OpenAIRE

    Lepoutre, Sophie

    2007-01-01

    This work is devoted to the development by the sol-gel process of ALnF4 (A=Li, Na and Ln=Y, Gd) fluorides and SiO2/LiGdF4 composites activated by Eu3+ ions. This synthesis process by a soft chemistry route, involving a sol as an intermediary step, enables the achievement of powders and coatings. The use of molecular precursors induces a homogeneous distribution of doping ions into the fluoride matrix avoiding any clustering effect. Several experimental tools (XRD, IR, Raman, EXAFS, NMR, EPR, ...

  3. Clinical significance of TNF-α in exhaled breath condensate of patients with ALI/ARDS%急性肺损伤/急性呼吸窘迫综合征患者呼出气冷凝液中TNF-α检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    葛珊珊; 陈建荣; 薛垒喜; 陈金亮; 徐志华

    2015-01-01

    目的:研究急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)患者呼出气冷凝液(EBC)中肿瘤坏死因子-α(TNF-α)检测的临床意义.方法:选择33例ICU中行机械通气的ALI/ARDS患者,用改进的德国JAEGER公司Ecoscreen呼出气冷凝液收集器收集EBC标本,同时收集血清标本;并选取20例健康体检者为对照组.采用ELISA法测定两组EBC和血清中TNF-α的浓度,分析患者EBC和血清中TNF-α水平与临床指标的相关性.结果:①ALI/ARDS患者EBC及血清中TNF-α水平高于健康对照组[(38.24±3.54) pg/ml vs.(11.52±9.71)pg/ml,(105.52±24.91) pg/ml vs.(32.71±9.11) pg/ml,P<0.01].②第1天、第3天及第7天ARDS组患者EBC中TNF-α水平均高于ALI组,P<0.05.③ALI组EBC及血清中TNF-α水平:第1天与第3天相比、第3天与第7天相比,EBC及血清中TNF-α水平存在差异(P<0.01);ARDS组EBC及血清中TNF-α水平:第1天与第3天相比、第3天与第7天相比,EBC及血清中TNF-α水平存在差异(P<0.01).④病死组EBC中TNF-α水平在第1天和第7天高于生存组(分别为P<0.05和P<0.01).⑤病死组EBC、血清中TNF-α水平于第1天和第3天及第3天和第7天相比,P<0.01;生存组EBC、血清中TNF-α水平于第1天与第3天及第3天与第7天相比,P<0.01.⑥EBC中TNF-α水平与PaO2/FiO2(P<0.01)、PaO2 (P<0.01)及APACHEⅡ评分(P<0.05)呈正相关,与AaDO2/PaO2呈负相关.结论:TNF-α的变化可以作为评估ALI/ARDS患者病情严重程度及预后的指标之一;用EBC检测ALI/ARDS患者TNF-α的变化较血清灵敏.

  4. A Discussion on the Ways of the Deep Cultivation of the Ability of Cross-border E-commerce---Practical Significance of Alibaba Ali Express Practical Courses%试论跨境电子商务能力的深度培养途径--阿里巴巴速卖通实操课程的实践意义

    Institute of Scientific and Technical Information of China (English)

    王前

    2016-01-01

    近年来,我国跨境电子商务飞速发展,已经形成了一定的产业集聚和交易规模,电商人才的拼抢空前激烈。在这个大背景下,各大院校纷纷探索跨境电商人才的培养模式和最佳途径。通过对阿里巴巴速卖通———国际淘宝卖家后台的模板设计进行分析,并将速卖通实操课程引入高职院校,将有助于对专业学生跨境电子商务职业能力的深度培养。%Nowadays,cross-border e-commerce is developing with a high speed. And a certain amount of business gathering and transaction scale have been existed. The seeking for qualified professionals is more intense than before in this field. Under the circumstances, many colleges are exploring for the modes and best ways for the training of professional personnel in the cross- board e-business. The article makes it clear why and how the Ali express practical courses can further develop the professional capacity for the students who major in business English, based on the analysis for the template design of Ali express———international Taobao.

  5. 钙钛矿型锂快离子导体Li3xLa0.67-xAlyTi1-2yNbyO3的制备及性能研究%Discussion on synthesis and characteristics of new Lithium fast ion conductors

    Institute of Scientific and Technical Information of China (English)

    连惠婷; 李荣华; 王文继

    2004-01-01

    以Li3xLa0.67-x TiO3为母体,通过掺杂经高温固相反应制得了一系列新的锂快离子导体材料Li3xLa0.67-xAlyTi1-2yNbyO3.X-射线衍射分析表明该系统(以下分别简称为Al-Nb)在x=0.10,y<0.050时,合成物为单一的钙钛矿固溶体,而当x=0.10,y≥0.050时,系统合成物还存在Al203杂相;应用交流阻抗技术测试其电导率,结果表明:该体系合成物在室温下有较高的电导率,可达2.52×10-4S/cm,在523 K时最高电导率可达4.76×10-3S/cm.活化能在20~25 kJ/mol之间,稳定性提高.

  6. The “Truth about White Slavery”. Présentation d’une enquête réalisée par Teresa Billington-Greig pour The English Review (juin 1913 The “Truth about White Slavery”. Presentation of an Investigation carried out by Teresa Billington-Greig for The English Review (June 1913

    Directory of Open Access Journals (Sweden)

    Christine Machiels

    2011-02-01

    Full Text Available En 1913, une féministe anglaise, Teresa Billington-Greig, publie dans The Eng­lish Review les résultats d’une enquête qu’elle a réalisée sur la traite des blan­ches. Alors que cette question suscite une agitation exceptionnelle (moral panic, sa recherche fait, à bien des égards, et au vu de la littérature de l’épo­que, figure d’exception. Symbole de toutes les angoisses d’une société victo­rienne en pleine mutation, la traite suscite de grandes émotions, auxquelles Teresa Billington-Greig oppose une réflexion basée sur l’étude des faits et la critique. Par son travail d’investigation inédit, qui répond aux critères de la re­cherche empirique, elle plaide plus largement pour une science sociale au ser­vice des réformes.In 1913, an English feminist, Teresa Billington-Greig, published the results of an enquiry she carried out on white slavery in The English Review. Whereas the question gave rise to moral panic, her research was, in many regards, and compared to the literature of the time, exceptional. The very symbol of all the anxieties of a Victorian society undergoing major changes, white slavery gave rise to high emotions, which Teresa Billington-Greig countered by reflection based on her study of the facts and criticism. By her unprecedented investigational work, which meets the criteria of empirical research, she launched a wider plea for a social science at the service of reforms.

  7. Challenge and Opportunity: the ALI/III Global Principles Project

    Directory of Open Access Journals (Sweden)

    IF Fletcher

    2008-04-01

    Full Text Available This article deals with an international project to establish the extent to which it is feasible to achieve a worldwide acceptance of the Principles of Cooperation among the NAFTA Countries together with the Guidelines Applicable to Court-to-Court Communications in Cross-Border Cases. This contribution explains the process whereby the American Law Institute and the International Insolvency Institute (1 developed principles of cooperation with regard to cross-border insolvency; (2 established acceptance of these principles in jurisdictions across the world, subject to any necessary local modifications; and (3 obtained the endorsement of leading domestic associations, courts, and other groups in those jurisdictions. This article may contribute to the development the South African cross-border insolvency law. The inclusion of the challenges of harmonisation of private international law is also contributing to current debate.

  8. INVENTORY OF THE INVASIVE ALIE N PLANT SPECIES IN INDONESIA

    Directory of Open Access Journals (Sweden)

    SRI S UDARMIYATI T JITROSOEDIRDJO

    2005-01-01

    Full Text Available An inventory of the alien plant species in Indone sia based on the existing references and herbarium specimens concluded that 1936 alien plant species ar e found in Indonesia which belong to 187 families. Field studies should be done to get the complete figur es of alien plant species in Indonesia. Based on the existing figures of the plant species, the invasive alien plant species can be iden tified, followed by studies on the assessment of losses, biology, management and their possible utilizations. Alien plant species are imported to Indonesia for cultivation, collection of the botanical garden, as experimental plants or other curiosities. Aside from plants purposely imported, there are also introduced plant propagules conta-minating imported agricultural products. These alien plant species can be beneficial or have a potential of being invasive. The alien cultivated species consisted of 67% of the total number. More than half of the cultivated plants are ornamental plants. Some of th e species are naturalized or escaped from cultivation and become wild and invasive. Some other natura lized species, adapted well without any problems of invasion. There are 339 species or 17% of the species r ecorded as weeds. The highest record of weeds is found in the family of Poaceae (57 species, follo wed by Asteraceae (53 species and Cyperaceae (35 species. There are 6 families having more than 10 species of weeds: Amaranthaceae, Asteraceae, Cyperaceae, Euphorbiaceae, Poaceae, and Rubiaceae. Three families have more than 100 species: Asteraceae 162 species, Poaceae 120 species, and Papillionaceae 103 species. Five species of aquatic and 20 species of terrestrial plants considered as important alien plant species in Indonesia were identified and some of their distributions noted

  9. A Dane visits the seraglios of Ali Pacha

    DEFF Research Database (Denmark)

    Isager, Jacob Erik

    2010-01-01

    The Danish archaeologist P.O. Brøndsted's visit to the seraglios of the Turkish governor of Northern Greece......The Danish archaeologist P.O. Brøndsted's visit to the seraglios of the Turkish governor of Northern Greece...

  10. Earth Observing 1 Advanced Land Imager (ALI): 2009-2010

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Global Land Survey (GLS) datasets are a collection of orthorectified, cloud-minimized Landsat-type satellite images, providing near complete coverage of the...

  11. Earth Observing-1 Advanced Land Imager (ALI): 2004-2008

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Global Land Survey (GLS) datasets are a collection of orthorectified, cloud-minimized Landsat-type satellite images, providing near complete coverage of the...

  12. Management in ekonomija: ali je to dvoje ali eno? (Elementi in razumevanje postocializma in managerske revolucije = Management and Economy: Are They the Same Or Not?

    Directory of Open Access Journals (Sweden)

    Tonci Kuzmanic

    2007-03-01

    Full Text Available Author starts from important but suppressed equalisation of economy and management in post socialist and post capitalist circumstances which represents the very essence of post-modern global dominance (globalisation. An attempt to distinguish economy from management is connected with the appearance of neo-liberalism as the central argumentative machinery of management being connected with postmodern type of subjectivity. In comparison with the so-called »objective law« around which economy used to revolve (ideally, of course, management explicitly leaves this terrain and opens itself up to the subjective, even subversive activity at the level of global society. In that sense economy and management are operating on two radically different levels and we could even speak of two different entities which should be analytically distinguished. The very supposition for modern defence with regard to post-modern forms of dominance is exactly a possibility of differentiating between economy and management.

  13. Theoretical aspects of soft power in Political Thoughts of Imam Ali (pbuh

    Directory of Open Access Journals (Sweden)

    Ali Adami

    2016-06-01

    Full Text Available This article studies the theoretical aspects of ‘soft power’ in Imam Ali’s (pbuh political thought, based on his approach. The theory of ‘soft power’, introduced by Joseph Nye in early 1990s in liberalism thought, can be interpreted and analyzed based on the principles of secularism, so that the study and analysis of political behavior presented in Nye theory reveals the saliency of propaganda and gossips, which declines the quality of norms and values and leads to mental recession in the behavior of power; however, the theoretical aspects of soft power in Imam Ali’s (pbuh political thought is interpretable in the framework of the ‘balance of rights’ theory, and this important principle is obviously visible through the study of his behaviors.According to the principles of the analysis, the main question outlined here is based on the following issue: How can the theoretical framework of soft power in Imam Ali’s (pbuh thought be interpreted and analyzed? The hypothesis of this study is as follows: Considering the extent and wide range of factors such as social justice, economic justice, political justice, etc. in Imam Ali’s (pbuh political performance, the theoretical framework of soft power in his thought does have the capability of interpretation and analysis based on the balance of rights index.

  14. KITAJSKA, PRILOŽNOST ALI TVEGANJE ZA NEMŠKO AVTOMOBILSKO INDUSTRIJO - PRIMER BMW

    OpenAIRE

    Grmek, Tine

    2014-01-01

    Nemška avtomobilska industrija je zelo pomembna za nemško gospodarstvo in zaposlovanje. Pomembni avtomobilski trgi za nemško avtomobilsko industrijo so poleg evropskega in ameriškega, še kitajski. Kitajska ima visoko gospodarsko rast in z njo se povečuje tudi povpraševanje po avtomobilih. Večina kitajskih proizvajalcev avtomobilov je v državni lasti. Ker kitajskim proizvajalcev manjkajo izkušnje, se združujejo v »Joint Venture« z mednarodnimi proizvajalci vozil. Kitajski trg ima vedno večjo k...

  15. Laser surface cladding of ZM5 Mg-base alloy with Al+Y powder

    Institute of Scientific and Technical Information of China (English)

    陈长军; 王东生; 王茂才

    2004-01-01

    The surface properties of ZM5 Mg-base alloy were modified by laser cladding with Al+ Y powder. Laser cladding was carried out with a 5 kW continuous wave CO2 laser by melting the preplaced powder mixture of Al and Y. Following laser cladding, the cladding zone was characterized by a detailed microstructural observation and phase analysis. Moreover, the microhardness and element distribution were evaluated in detail. The surface modified layer consists of Mg17 Al12 and Al4 MgY phases, while a-Mg and Mg17 Al12 in the substrate. The microhardness of the cladding zone was significantly enhanced as high as HV122 - 180 as compared to HV60 - 80 of the substrate region. The maximal hardness about HV224 is in the interface due to the formation of intermetallic Mg17 Al12 phase. The microstructure is refined and Mg diffuses into the cladding material which leads to the formation of Mg17 Al12.

  16. Émeutes, ségrégation urbaine et aliénation politique

    OpenAIRE

    Lagrange, Hugues

    2008-01-01

    Three weeks of urban riots of October and November, 2005, were an exceptional collective episode of violence, even in France where the tradition of protest is lively. Their scale, their concentration in the time, their spectacular character drew the attention of the international press. We are interested here in the social and structural dimensions of these riots, underlining first the effects of the differences between cities on a demographic plan, on that of the employment situation and hou...

  17. Is surfactant a promising additive drug in ALI/ARDS-patients?

    NARCIS (Netherlands)

    Schultz, MJ; Kesecioglu, J

    2004-01-01

    The rationale for surfactant replacement therapy in patients with acute respiratory distress syndrome (ARDS) is to restore the normal composition of the surfactant system, as well as to overcome ongoing inactivation of present surfactant. Indeed, surfactant replacement therapy call normalize the com

  18. Magnetic ordering in PrBa2Cu3-yAlyO6+x

    DEFF Research Database (Denmark)

    Longmore, A.; Boothroyd, A.T.; Chen, C.K.

    1996-01-01

    The magnetic ordering in single crystals of PrBa2CU3O6+x has been investigated by elastic neutron scattering over the full range of temperatures for reduced and oxygenated crystals. The crystals were grown in alumina crucibles and therefore contained dissolved aluminum on the Cu(1) site. Both...... aluminum and oxygen contents were analyzed in detail in order to establish their effects on the magnetic ordering, Our crystals exhibited Pr ordering and the two types of antiferromagnetic Cu ordering frequently reported in related compounds, but our results differ in several respects from previous studies...

  19. Development of Resource Sharing System Components for AliEn Grid Infrastructure

    CERN Document Server

    Harutyunyan, Artem

    2010-01-01

    The problem of the resource provision, sharing, accounting and use represents a principal issue in the contemporary scientific cyberinfrastructures. For example, collaborations in physics, astrophysics, Earth science, biology and medicine need to store huge amounts of data (of the order of several petabytes) as well as to conduct highly intensive computations. The appropriate computing and storage capacities cannot be ensured by one (even very large) research center. The modern approach to the solution of this problem suggests exploitation of computational and data storage facilities of the centers participating in collaborations. The most advanced implementation of this approach is based on Grid technologies, which enable effective work of the members of collaborations regardless of their geographical location. Currently there are several tens of Grid infrastructures deployed all over the world. The Grid infrastructures of CERN Large Hadron Collider experiments - ALICE, ATLAS, CMS, and LHCb which are exploi...

  20. Antibiotic Resistance Pattern in Urinary Tract infections in Imam-Ali Hospital,

    Directory of Open Access Journals (Sweden)

    Mohsen Rajabnia-Chenari

    2012-08-01

    Full Text Available Background: Treatment for urinary tract infection should be based on common uropathogenes and their resistance to antibiotics. The aim of this study was to evaluate antibiotic resistance patterns in urinary tract infection. Materials and Methods: In this cross-sectional study, 11 common antibiotics were evaluated with antibiogram on urine samples of 2876 cases with urinary tract infection during 2010-2011. Results: The most common uropathogen was E. coli (62.41% and highest resistance of pathogen was against cefixime (84.5% in this study.Conclusion: As the least resistance of uropathogens was against ciprofloxacin, we propose this antibiotic as the first line treatment for urinary tract infection.

  1. The Al(I) molecule, Ph2COAl and its anion

    Science.gov (United States)

    Zhang, Xinxing; Eichhorn, Bryan; Schnöckel, Hansgeorg; Bowen, Kit

    2016-08-01

    We have formed the Al(I)-containing molecule, benzophenone-aluminum, i.e., Ph2COAl, and studied it by conducting density functional theory calculations on both its neutral and anionic forms and by measuring the photoelectron spectrum of its anion. Our calculations identified two nearly iso-energetic anion isomers, (Ph2COAl)-, the vertical detachment energies (VDE) of which are in excellent agreement with our photoelectron spectrum. Natural population analysis (NPA) of Ph2COAl found the Al moiety to be positively charged by +0.81 e, indicating a strongly ionic bond between Al and Ph2CO, i.e., Ph2CO-Al+.

  2. Regstellende aksie, aliënasie en die nie-aangewese groep / Dirk Johannes Hermann

    OpenAIRE

    2006-01-01

    Affirmative action is a central concept in South African politics and the workplace. The Employment Equity Act divides society into a designated group (blacks, women and people with disabilities) and a non-designated group (white men and white women). In this study, the influence of affirmative action on alienation of the non-designated group was investigated. Guidelines were also developed for employers in order to lead the non-designated group from a state of alienation to th...

  3. Oxidation resistant and low coefficient of thermal expansion Nia1-CoCrAly alloy

    Science.gov (United States)

    Hebsur, Mohan G. (Inventor)

    2004-01-01

    A bond coat composition for use in thermal barrier coatings comprises a NiAl--CoCrAlY matrix containing particles of AlN dispersed therein. The bond coat composition is prepared by croymilling NiAl and CoCrAlY in liquid nitrogen.

  4. A Glance at Mohammad Ali Bahmani’s Innovation in the Form of Sonnet

    OpenAIRE

    f Modaressi; R. Kazemzadeh

    2012-01-01

    Form, known as a unified set of poetic language, imagery and music, is one of the fundamental building blocks of poem that goes beyond framework and appearance of poem. Form of a poem is not identical to its framework and hence does not encompass the poem’s content. Rather, form takes shape along with the process of poem emergence. That is why most poets’ sonnets are non-identical despite enjoying an analogous appearance. In other words, form can be referred to as the manner in which content ...

  5. VARIETY OF GRAY-SCALE SONOGRAPHIC APPEARANCE OF UNTREATED LIVER METASTASES ALI HADIDI

    Directory of Open Access Journals (Sweden)

    ALI HADIDI

    1982-07-01

    Full Text Available Encountered wit h b izarre patterns o f l i v e r metas t a s es dec l i ned our accuracy rate s o the humi liation o f mist ake s motivated me to re-assess t he value o f hepatic sonography in patients s u spe c t ed o f having metastatic l i ver neoplasms . 43 pat ients , who had no t recieved any prior the r a phy , had been studied by gray-scale ult r a s ound . The echographic evidence i n accordance with o ur e x p e r ~ e n ce can be categorized as fo l l ows : I l a rge echo g enic or ~c ho poor area , II d iscrete masse s wi t.h high-level e c hoes spreaded t hroughout a lobe o f the l i ve r , III e cho f ree mass with i r regular mar q i.n , r .J d i f f use a lterat ion of the homogeneous e cho pattern of t he liver , V Bull ' s - eye ,VI abscess like,VII sol id echogenic mass vei th a centra l hyperechoic hor izontal l i ne , VIII echogenic mass ".;i t;l two l a t eral hypo e choic marg i n s, rX isodense e chog eni c a r ea bounded by an hypoechoic c i r c l e . The f e at u r e s seen i n l iver ultra sonography of t he entire pat t e r ns , a nd those s e en as new c r i teria are presented ~

  6. PENJERNIHAN NIRA TEBU MENGGUNAKAN MEMBRAN UL TRAFIL TRASI DENGAN SISTEM ALI RAN SILANG

    Directory of Open Access Journals (Sweden)

    Suprihatin

    2007-08-01

    Full Text Available Membrane ultrafiltration is one alternative technology to produce a high quality cane sugar with reasonable cost, because its ability to produce a brighter color and lower impurities as well as sulphur free of product. This technology can reduce process steps, chemical and energy demand, so that the production cost is potentially reduced significantly. This research work was aimed to study the performance of various membrane filtrations in the application for clarifying sugar cane juice, covering the achievable flux, membrane rejection againstimpurities, and quality of the filtered juice. The experiments were conducted according to the principle of cross flow using three different transmembrane pressures of 0.7, 1.4, and 2.1 bar and cross flow rate of 0.42 m/s. Various membranes were studied in this experiments both commercial ultrafiltration membrane and ultrafiltration membrane prepared in our laboratory. Sugar cane juice before and after clarification were characterized by measuring the parameters of brix, sucrose concentration, solution color, clarity, and pH. Thepolisulfone membrane, which was prepared in our laboratory, produced fluxes in the range of 25-30 L/m2.h at the transmembrane pressures of 0.7-2.1 bar. The membranes increased clarity of the juice from app. 10 to 60% of transmition and reduced color up to 80-90%, comparable with the results of the commercial ultrafiltration membrane

  7. Optimization and Calculation of TbCl3-ACl (A=Li, Na, K, Rb, Cs) Phase Diagrams

    Institute of Scientific and Technical Information of China (English)

    Sun Yimin; Zhang Jing; Guan Mingyun; Qiao Zhiyu

    2005-01-01

    By using CALPHAD (Calculation of Phase Diagram) technique the optimization and calculation of the binary systems of TbCl3-ACl (A= Li, Na, K, Rb, Cs) were carried out. For describing the Gibbs free energy of liquid phase in these systems the new modified quasichemical model in the pair-approximation for short-range ordering was used. From measured phase equilibria data and experimental integral properties the TbCl3-ACl phase diagrams were optimized and calculated. A set of thermodynamic functions was optimized based on an interactive computer-assisted analysis. The calculated phase diagrams and thermodynamic data are self-consistent.

  8. Reply to Ali & Aitchison's comment on 'Restoration of Cenozoic deformation in Asia, and the size of Greater India'

    NARCIS (Netherlands)

    van Hinsbergen, D.J.J.; Lippert, P.C.; Dupont-Nivet, G.; Kapp, P.; DeCelles, P.G.

    2012-01-01

    In our recent paper [van Hinsbergen et al., 2011a], we provide a kinematic restoration of Cenozoic deformation in Asia based on the currently available kinematic estimates on fault zones and fold-thrust belts in Tibet, the Pamir, the Tien Shan, Mongolia, Siberia and Indochina. Our reconstruction sug

  9. The Prevalence of fungal infections in children with hematologic malignancy in Ali-Asghar Children Hospital between 2005 and 2010

    OpenAIRE

    Ansari, Sh.; Shirzadi, E; Elahi, M

    2015-01-01

    Background A fungal infection represents a growing problem in children with hematologic malignancies, during chemotherapy induced neutropenia. Fungal colonization is considered a major risk factor for subsequent fungal infections. The aim of this retrospective study was to evaluate prevalence of fungal infection among children admitted to hospital between 2005 and 2010 in Tehran, Iran. Materials and Methods 617 hematological patients in the age range of neoteric to 19 years old were enrolled ...

  10. Supports visuels réalisés dans le cadre des travaux pratiques de Chimie Analytique (Partie II)

    OpenAIRE

    Ziemons, Eric; Lejeune, Robert; Hubert, Philippe

    2008-01-01

    Plusieurs vidéos (étalonnage des pipettes, argentimétrie: méthode de Fajans et argentimétrie: méthode de Mohr) illustrent les manipulations des travaux pratiques de 2ème Baccalauréat en Sciences pharmaceutiques.

  11. Supports visuels réalisés dans le cadre des travaux pratiques de Chimie Analytique (Partie I)

    OpenAIRE

    Ziemons, Eric; Houbart, Virginie; Lejeune, Robert; Hubert, Philippe

    2007-01-01

    Plusieurs vidéos (utilisation de la burette, calibration de la balance analytique, nettoyage de la balance analytique, gravimétrie, rinçage des pipettes, prélèvement à l'aide d'une pipette à 1 trait, prélèvement à l'aide d'une pipette à 2 traits et transfert quantitatif) illustrent le B.A.-BA des manipulations des travaux pratiques de 2ème Baccalauréat en Sciences pharmaceutiques.

  12. Entre réalisable et réalisé : DE et LIAO potentiels en chinois du nord

    OpenAIRE

    Lamarre, Christine

    1994-01-01

    International audience; This paper discusses two grammatical formatives which encode a potential meaning when added to a resultative compound : DE in Standard Mandarin (which comes from the verb 'get'), and LIAO/LAO in some non-standard Northern Mandarin dialects. Both forms also show a perfectivizing function in other environments. The potential suffix LIAO was never discussed before in the literature, whereas DE and its historical development are a much studied topic. We analyze the link be...

  13. Vladimir Nabokov, un exemple d’aliénation créatrice Vladimir Nabokov, an Instance of Creative Alienation

    Directory of Open Access Journals (Sweden)

    Marie Bouchet

    2009-06-01

    Full Text Available The terms “strange” and “stranger” derive from extraneus, a Latin word literally meaning “outside of”. This article proposes to examine the notions of distance and limit which shape the consciousness of a foreigner / outsider—Vladimir Nabokov. Nabokov lost his native land when he was 18, and was condemned to remain a stranger in a foreign land. In his fiction, many “estranged” characters are to be found, especially as main focalizers or first-person narrators. The present article thus demonstrates how the concept of frontier is crucial to interpreting such alien status: these characters are forever estranged, due to geographical borders, temporal distances or linguistic barriers. Nabokov, himself a trilingual writer, challenged the very idea of a foreign language. His English, which he claimed was merely “second rate”, is indeed quite different from the style of American classics, yet it has a unique poetic flavor. Maybe because he “did not think in any language, but in images”, his condition as a foreigner was not felt as alienating. Contrary to most of his characters, hybridization seems to have been a powerful element inspiring his artistic impulse, as illustrated in his extraordinary linguistic virtuosity and his constant playing on words. Similarly, the repeated inclusion of other semiotic codes (painting, photography, advertisements,… shows that by playing with limits and the interpenetration of familiar and strange(r elements, Nabokov found a creative alternative to the usually alienating condition of being a foreigner.

  14. Reading Studies Of A Story Named “Şarap Lekesi” By Hasan Ali Toptaş

    Directory of Open Access Journals (Sweden)

    Mustafa ÇALDAK

    2009-06-01

    Full Text Available Şarap Lekesi, which includes meaning blanks, reticence and numerous dark points, is a story which melts the real truth and fiction world into each other, creating a new world, and in which the author leaves his dominant position to readers. The story embraces as many meanings as its number of readers. There is no single focused idea/meaning in the text. The plot of the story is based on a wine spot on a table, and imaginary characters are created, and the dog, Alyoşa, is used as a metaphor for reticence/ silence. This short and deep story is analyzed in three aspects: the sole existence of the text as an object; Alyoşa as the language of reticence/silence and self-deconstruction.

  15. Siserände suundumused 20. sajandil = Trends of internal migration during the 20th century and at the beginning of the 21st century / Alis Tammur

    Index Scriptorium Estoniae

    Tammur, Alis

    2008-01-01

    Siserände suundadest Eestis alates 1920ndatest aastatest kuni 2007. aastani. Kaart: Linnadesse tulnud endise alalise elukoha järgi, 1922-1934. Graafik: Siserände vanusjaotus. Tabel: Linnade ja maa-asulate vahelised rändesuunad 2000-2007

  16. Contrôlabilité : Suivi des mesures de CFL réalisées avec des pneumatiques AIPCR 07 et ASTM 07

    OpenAIRE

    Cerezo, Véronique; CENTRE D'ETUDES TECHNIQUES DE L'EQUIPEMENT DE LYON - CETE LYON; LABORATOIRE REGIONAL DES PONTS ET CHAUSSEES DE LYON - CETE DE LYON - LRPC LYON

    2010-01-01

    L'étude a pour objet l'étude du comportement des pneumatiques ASTM 07 et AIPCR 07 par rapport à celui des pneus standards d'essais AIPCR 98 utilisés pour les mesures de coefficient de frottement longitudinal. Tout d'abord, les pneumatiques ASTM 07 et AIPCR 07 semblent plus tendres que les pneus AIPCR 98. Il est nécessaire de les laisser vieillir quelques temps afin de revenir à des niveaux équivalents à ceux des pneus AIPCR 98 utilisés depuis une dizaine d'années en France pour les mesures de...

  17. First principles study of structural, elastic, electronic and magnetic properties of Mn-doped AlY (Y=N, P, As) compounds

    Energy Technology Data Exchange (ETDEWEB)

    Sajjad, M. [School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876 (China); Alay-e-Abbas, S.M. [Department of Physics, University of Sargodha, Sargodha 40100 (Pakistan); Department of Physics, Government College University, Faisalabad, Allama Iqbal Road, Faisalabad 38000 (Pakistan); Zhang, H.X. [School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876 (China); Beijing Key Laboratory of Work Safety Intelligent Monitoring (Beijing University of Posts and Telecommunications), Beijing 100876 (China); Noor, N.A. [Centre for High Energy Physics, University of the Punjab, Quaid-e-Azam Campus, 54590 Lahore (Pakistan); Saeed, Y. [Department of Physics, Government College University, Faisalabad, Allama Iqbal Road, Faisalabad 38000 (Pakistan); Shakir, Imran [Deanship of scientific research, College of Engineering, King Saud University, P. O. BOX 800, Riyadh 11421 (Saudi Arabia); Shaukat, A., E-mail: schaukat@gmail.com [Department of Physics, University of Sargodha, Sargodha 40100 (Pakistan)

    2015-09-15

    We investigate zinc-blende phase Al{sub 0.75}Mn{sub 0.25}Y (Y=N, P, As) compounds using full-potential linear-augmented-plane wave plus local-orbital method. For computing structural and elastic properties the Generalized Gradient Approximation (GGA) has been used; whereas the electronic and magnetic properties are examined at the optimized GGA lattice parameters by employing modified Becke and Johnson local density approximation. All these compounds are found to be stable in ferromagnetic ordering in the zinc-blende structure which is supported by the computed elastic constants. The nature of electronic band structure are calculated and the nature of band gaps in the doped system is analyzed. The results are examined to identify exchange mechanism which is the main source of introducing ferromagnetism in the compounds under investigation. Spin charge density contour plots in the (1 1 0) plane and the evaluation of s–p and p–d exchange constants (N{sub 0}α and N{sub 0}β) are evaluated for understanding bonding and exchange splitting process, respectively. - Highlights: • Spin-polarized DFT investigation Mn-doped AlN, AlP and AlAs is reported. • Structrual and elastic properites are computed for evaluating stability. • mBJLDA used for appropriate treatment of d states of Mn for electronic properties. • Half metallicity, ferromagnetic stability and exchange constants are evaluated.

  18. Acoustic phonon modes in asymmetric AlxGa1-xN/GaN/AlyGa1-yN quantum wells

    Science.gov (United States)

    Zan, Y. H.; Ban, S. L.; Chai, Y. J.; Qu, Y.

    2017-02-01

    Using an elastic continuum model, the dispersion relations and phonon modes of propagating, confined, half space and interface acoustic phonons in asymmetric AlxGa1-xN/GaN/Al1-yGayN quantum wells (QWs) have been solved theoretically with the varieties of Al components x and y. Contrary to the previous conclusions, some regulations for the existence of the above different acoustic phonons are revealed as well as the transition conditions among these modes are also discussed. With increase of wave vectors, the dispersion relations split into several groups. Because the classification of these groups is related to the eigen frequencies of bulk materials forming QWs, phonon modes in these groups will be confined or propagating in different layers of QWs. Furthermore, the gradients of the dispersion relations' asymptotes are the velocities of longitudinal and the transverse acoustic phonons propagating in bulk materials in turns. The properties of the dispersion relations and their phonon modes are also analyzed in depth based on the cut-off conditions. By the changing of Al components x and y, the bottom of these groups will be modified to adjust eigen frequencies of AlxGa1-xN or Al1-yGayN layers. But the propagation properties of acoustic phonon modes will remain unchanged in each section.

  19. China and Egypt:More Cooperation Brings Prosperous Future--Interview with H.E.Ali El-Hefny,Ambassador of Egypt to China

    Institute of Scientific and Technical Information of China (English)

    Liu Yun

    2004-01-01

    @@ Q:With long history and outstanding cultural achievements, China and Egypt have good cooperation in politics,economy, tourism, and education. Focusing on economy, what complementarities do you think our two countries have? What kind of potentials could be discovered and in which aspects could we enhance economic and trade cooperation?

  20. Suivi de l'eutrophisation en Baie de Douarnenez - Estimation de la biomasse en algues vertes (Mission réalisée le 1° aout 1996)

    OpenAIRE

    1996-01-01

    La mission menée dans le cadre du programme concernant le suivi de l'eutrophisation en baie de Douarnenez s'est déroulée le 1er août 1996. Ce travail fait partie d'un programme de lutte contre les marées vertes, coordonné par l'IFREMER et le CEMAGREF dans le cadre du Contrat de Plan Etat-Région et intitulé : Bassins versants et transmission des pollutions au littoral. Cette mission comprenant les prises de vues aériennes et les échantillonnages de terrain s'est déroulée lors d'un coefficient ...

  1. Excitonic localization in AlN-rich AlxGa1−xN/AlyGa1−yN multi-quantum-well grain boundaries

    KAUST Repository

    Ajia, Idris A.

    2014-09-22

    AlGaN/AlGaN multi-quantum-wells (MQW) with AlN-rich grains have been grown by metal organic chemical vapor deposition. The grains are observed to have strong excitonic localization characteristics that are affected by their sizes. The tendency to confine excitons progressively intensifies with increasing grain boundary area. Photoluminescence results indicate that the MQW have a dominant effect on the peak energy of the near-bandedge emission at temperatures below 150 K, with the localization properties of the grains becoming evident beyond 150 K. Cathodoluminescence maps reveal that the grain boundary has no effect on the peak intensities of the AlGaN/AlGaN samples.

  2. Comparison of Resistance Symbols in Poems of Kaiser Aminpoor and Ayyed Hassan Hosseini with Poems of Ali Ahmad Sa'id and Jabra Ibrahim Jabra (Adonis

    Directory of Open Access Journals (Sweden)

    Amir Haj Alizadeh

    2017-01-01

    Full Text Available The resistance poets provide exquisite images of natural phenomena, personalities, and religious, historical, mythological, epic and national events. Selection and usage of these images as symbols of resistance in the poems depict the mood of fight as well as the other concepts to the reader. By implementing a comparative study on the resistance symbols in the poems discussed in this study. This article shows that natural symbols have high frequency and the similarity of the symbols in each of four categories (natural, religious, historical, epic and other symbols are very low because of differences in ideas. Examining the content of the heavily used symbols by Arab poets suggest that they discourse to consciousness of the Arab nation. However, in the case of Iranian poets, they try to strengthen the spirit of struggle and resistance against a hostile force. The most important feature of the symbols of Arab poets is the use of self-made and private symbols to a very high extent, and this can be seen in the poets in Iran very low. Arab poets, in orientation to the West, have used in a large amount of mythological symbols outside their territory, especially Greece and Egypt that don’t appear in Iranian poets.

  3. Reply to Aitchison and Ali: Reconciling Himalayan ophiolite and Asian magmatic arc records with a two-stage India-Asia collision model

    NARCIS (Netherlands)

    van Hinsbergen, D.J.J.; Lippert, P.C.; Dupont-Nivet, G.; McQuarrie, N.; Doubrovine, P.V.; Spakman, W.; Torsvik, T.H.

    2012-01-01

    We recently presented a compilation of paleomagnetic data arguing for Cretaceous extension within Greater India. These data imply that a Tibetan Himalayan (TH) microcontinent rifted away from India, opening an oceanic Greater India Basin (GIB) in its wake. Consequently, we postulated a two-stage Ind

  4. Barriers of the Development of Web-Based Training in Agricultural Higher Education System in Iran: A Case Study of Hamadan Bu Ali Sina University, Iran

    Science.gov (United States)

    Saadi, Heshmatollah; Mirzayi, Khalil; Movahedi, Reza

    2016-01-01

    Recently, higher education systems seek to use network-based and Internet-based information technologies in education, teaching and learning. E-learning in Iran higher education system has been started since 2003, however, its development has been very slow. The present study is a survey research. The participants of the study are faculty members,…

  5. Development of Chromatographic Fingerprints of Eurycoma longifolia (Tongkat Ali) Roots Using Online Solid Phase Extraction-Liquid Chromatography (SPE-LC).

    Science.gov (United States)

    Zaini, Nor Nasriah; Osman, Rozita; Juahir, Hafizan; Saim, Norashikin

    2016-04-30

    E. longifolia is attracting interest due to its pharmacological properties and pro-vitality effects. In this study, an online SPE-LC approach using polystyrene divinyl benzene (PSDVB) and C18 columns was developed in obtaining chromatographic fingerprints of E. longifolia. E. longifolia root samples were extracted using pressurized liquid extraction (PLE) technique prior to online SPE-LC. The effects of mobile phase compositions and column switching time on the chromatographic fingerprint were optimized. Validation of the developed method was studied based on eurycomanone. Linearity was in the range of 5 to 50 µg∙mL(-1) (r² = 0.997) with 3.2% relative standard deviation of peak area. The developed method was used to analyze 14 E. longifolia root samples and 10 products (capsules). Selected chemometric techniques: cluster analysis (CA), discriminant analysis (DA), and principal component analysis (PCA) were applied to the fingerprint datasets of 37 selected peaks to evaluate the ability of the chromatographic fingerprint in classifying quality of E. longifolia. Three groups were obtained using CA. DA yielded 100% correlation coefficient with 19 discriminant compounds. Using PCA, E. longifolia root samples were clearly discriminated from the products. This study showed that the developed online SPE-LC method was able to provide comprehensive evaluation of E. longifolia samples for quality control purposes.

  6. Oxidative Cleavage of C=S and P=S Bonds at an Al(I) Center: Preparation of Terminally Bound Aluminum Sulfides.

    Science.gov (United States)

    Chu, Terry; Vyboishchikov, Sergei F; Gabidullin, Bulat; Nikonov, Georgii I

    2016-10-10

    The treatment of cyclic thioureas with the aluminum(I) compound NacNacAl (1; NacNac=[ArNC(Me)CHC(Me)NAr](-) , Ar=2,6-Pr(i)2 C6 H3 ) resulted in oxidative cleavage of the C=S bond and the formation of 3 and 5, the first monomeric aluminum complexes with an Al=S double bond stabilized by N-heterocyclic carbenes. Compound 1 also reacted with triphenylphosphine sulfide in a similar manner, which resulted in cleavage of the P=S bond and production of the adduct [NacNacAl=S(S=PPh3 )] (8). The Al=S double bond in 3 can react with phenyl isothiocyanate to furnish the cycloaddition product 9 and zwitterion 10 as a result of coupling between the liberated carbene and PhN=C=S. All novel complexes were characterized by multinuclear NMR spectroscopy, and the structures of 5, 9, and 10 were confirmed by X-ray diffraction analysis. The nature of the Al=S bond in 5 was also probed by DFT calculations.

  7. Comparison of total antioxidant capacity of saliva in type2 diabetic patients and healthy persons referring to zahedan Ali Asghar hospital

    Directory of Open Access Journals (Sweden)

    Maryeh Honarmand

    2013-09-01

    Full Text Available Background: In the human body, there are some special systems to interact with pathogens of free radicals that are called antioxidant immune system in some human diseases. Diabetes is one of the most important common chronic diseases with changing in antioxidant capacity. Therefore, this research was done with the purpose of determination and comparison of antioxidant capacity of diabetic patients, saliva with control Grope. Material and Methods: This study was a case control study. 50 people with type II diabetes referring to Zahedan diabetic center assigned as case group, they were compared with 50 participants from control group. Both groups had similar age, sex and all other criteria. Total antioxidant capacity of saliva evaluated with FRAP (Ferric reducing ability of plasma method. The data was analyzed by T-test and ANOVA. Results: Mean and standard deviation (Mean ± SD of antioxidant capacity of saliva in case group was 0.442±0.251 µmol/liter and in control group was 0.667±0.421 µmol/liter. Reduction of antioxidant capacity of saliva of case group was statistically significant using T-test and ANOVA analysis (p=0.002. Conclusion: In this study reduction of antioxidant capacity of diabetic patients, saliva was significantly lower than control group. Therefore, it is recommended that these people use more natural antioxidants.

  8. Slovenska »mala« inovativnost: nenehno izboljševanje ali trajna stagnacija? = Slovenian Employee Suggestion Systems: A Continuous Improvement Or a Continuous Stagnation?

    Directory of Open Access Journals (Sweden)

    Peter Fatur

    2010-12-01

    Full Text Available The operations management theory emphasizes the management ofincremental innovations as one of the cornerstones for continuous improvementof a firm’s operational efficiency. Also in Slovenia, the companiesfollow the foreign practices in this field as well as developingtheir own solutions. Unfortunately, the introduction of employee suggestionsystems very often turns out to be a failure. The paper aimsto analyze the incremental innovation management systems, in particularthe employee suggestion systems, on a sample of Sloveniancompanies from the automotive and fabricated metal products industry.Based on the key output indices, two groups of companies are definedwith a different ability to introduce innovations. The main differencesin the organization of the employee suggestions managementbetween the two groups are presented. As such, the research resultsmay contribute to an improvement and further growth of these systemsin Slovenian companies.

  9. On the crystal energy and structure of A2TinO2n+1 (A=Li, Na, K) titanates by DFT calculations and neutron diffraction

    Science.gov (United States)

    Catti, Michele; Pinus, Ilya; Scherillo, Antonella

    2013-09-01

    First-principles quantum-mechanical calculations (CRYSTAL09 code, B3LYP functional) were performed on alkali titanates A2TinO2n+1 with layered structure (n=3,4,6). Monoclinic structural types with unshifted (P21/m) and with shifted (C2/m) layers were considered. Crystal energies and full structural details were obtained for all Li, Na, and K phases. Neutron diffraction data were collected on powder samples of P21/m-Li2Ti3O7 (a=9.3146(3), b=3.7522(1), c=7.5447(3) Å, β=97.611(4)°) and C2/m-K2Ti4O9 (a=18.2578(8), b=3.79160(9), c=12.0242(4) Å, β=106.459(4)°) and their structures were Rietveld-refined. Computed energies show the P21/m arrangement as favoured over the C2/m one for n=3, and the opposite holds for n=6. In the n=4 case the P21/m configuration is predicted to be more stable for Li and Na, and the C2/m one for K titanates. Analysis of Li-O and K-O crystal-chemical environments from experiment and theory shows that the alkali atom bonding is stabilized/destabilized in the different phases consistently with the energy trend.

  10. 一种新型通用全数字时钟匀滑技术%A Novel Universal Ali-Digital Clock Smoothness Technique

    Institute of Scientific and Technical Information of China (English)

    秦晓懿; 王瀚晟; 曾烈光

    2001-01-01

    针对锁相环在匀滑含有低频大幅度的抖动和漂移的时钟时有诸如同步和捕捉范围很窄、容易失锁等缺点,提出了一种新的全数字时钟匀滑技术一统计预测法.其主要思想是用一个周期的统计结果来预测下一个周期的处理值.从该方法的原理和性能分析可知,其可有效的匀滑各种抖动和漂移,抖动积累较小,同步和捕捉范围很宽,可以匀滑不同频率的时钟.另外,改进的变周期的统计预测法也可使捕捉时间降到合适的长度,以适用于不同场合.

  11. Hospital contacts for endocrine disorders in Adult Life after Childhood Cancer in Scandinavia (ALiCCS): a population-based cohort study

    DEFF Research Database (Denmark)

    de Fine Licht, Sofie; Winther, Jeanette Falck; Gudmundsdottir, Thorgerdur

    2014-01-01

    BACKGROUND: The pattern of endocrine disorders in long-term survivors of childhood cancer has not been investigated comprehensively. Here, we aimed to assess the lifetime risk of these disorders in Nordic survivors of childhood cancer. METHODS: From the national cancer registries of Denmark...... were linked to the national hospital registries, and observed numbers of first-time hospital contacts for endocrine disorders in survivors of childhood cancer were compared with the expected numbers derived from the population comparison cohort. We calculated the absolute excess risks attributable...... to status as a childhood cancer survivor and standardised hospitalisation rate ratios (SHRRs). FINDINGS: Of the childhood cancer survivors, 3292 had contact with a hospital for an endocrine disorder, yielding a SHRR of 4·8 (95% CI 4·6-5·0); the highest risks were in survivors of leukaemia (SHRR 7·3 [95% CI...

  12. A STUDY ON PREVAL E NCE OF BIRTH DEFECTS AND ITS ASSOCIATION WITH RISK FACTORS IN FAKHRUDHIN ALI AH MED MEDICAL COLLEGE AND HOSPITAL

    Directory of Open Access Journals (Sweden)

    Alpana

    2015-07-01

    Full Text Available OBJECTIVE: Congenital anomalies or Birth Defects are a global problem. It is the most common cause of disability in developed and developing countries. This study aims to evaluate the overall prevalence of clinically detectable congenital anomalies in newborns along with the different forms of congenital anomalies and associated risk factors if any over a period of one year. MATERIALS AND METHOD S: I t’s an observational analytical cross sectional type of study. Seven thousand seven hundred and ninety eight babies born during the period from 1 st Nov, 2013 to 31 st Oct, 2014 were analyzed. Details of cases were recorded after parent’s interviews, clinical, radiological and laboratory evaluations. RESULTS: In our study, we have found that out of the total no. of 7798 babies born during the said period, the total number of congenital anomalies found were 53 0.7%. Cleft lip and palate was the most common anomaly followed by clubfoot. System wise, congenital anomaly of the musculoskeletal system was the highest (45.3%. A male preponderance is seen with M:F = 4:3. Maximum number of anomalies was found in the 20 - 25 y rs of age group. Moreover, anomalies were found more in primi gravida. Various risk factors were associated in 9 numbers of cases out of 53. CONCLUSIONS: Prevalence of congenital anomaly was found to be 0.7% and therefore awareness about preventable risk f actors should be created and early prenatal diagnosis and management of anomalies is recommended.

  13. Effect of integrated pest management on controlling zoonotic cutaneous leishmaniasis in Emamzadeh Agha Ali Abbas (AS District, Isfahan province, 2006-2009

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Nilforoushzadeh

    2014-01-01

    Conclusion: The only scientific method for preventing and controlling zoonotic CL (ZCL is a combination of the control methods (improving the environment and fighting off the disease districts and vectors together with changing the vegetative cover of the region. Any measure for controlling this disease must be taken and programmed in accordance with the relevant experts′ views, in coordination with the participation of other organizations and the society.

  14. Influence of inelastic collisions with hydrogen atoms on the formation of AlI and SiI lines in stellar spectra

    Science.gov (United States)

    Mashonkina, L. I.; Belyaev, A. K.; Shi, J.-R.

    2016-06-01

    We have performed calculations by abandoning the assumption of local thermodynamic equilibrium (within the so-called non-LTE approach) for Al I and Si I with model atmospheres corresponding to stars of spectral types F-G-Kwith differentmetal abundances. To take into account inelastic collisions with hydrogen atoms, for the first time we have applied the cross sections calculated by Belyaev et al. using model approaches within the formalism of the Born-Oppenheimer quantum theory. We show that for Al I non-LTE leads to higher ionization (overionization) than in LTE in the spectral line formation region and to a weakening of spectral lines, which is consistent with earlier non-LTE studies. However, our results, especially for the subordinate lines, differ quantitatively from the results of predecessors. Owing to their large cross sections, the ion-pair production and mutual neutralization processes Al I( nl) + HI(1 s) ↔ Al II(3 s 2) + H- provide a close coupling of highly excited Al I levels with the Al II ground state, which causes the deviations from the equilibrium level population to decrease compared to the calculations where the collisions only with electrons are taken into account. For three moderately metal-deficient dwarf stars, the aluminum abundance has been determined from seven Al I lines in different models of their formation. Under the assumption of LTE and in non-LTE calculations including the collisions only with electrons, the Al I 3961 ˚A resonance line gives a systematically lower abundance than the mean abundance from the subordinate lines, by 0.25-0.45 dex. The difference for each star is removed by taking into account the collisions with hydrogen atoms, and the rms error of the abundance derived from all seven Al I lines decreases by a factor of 1.5-3 compared to the LTE analysis. We have calculated the non- LTE corrections to the abundance for six subordinate Al I lines as a function of the effective temperature (4500 K ≤ T eff ≤ 6500 K), surface gravity (3.0 ≤ log g ≤ 4.5), and metal abundance ([M/H] = 0, -1, -2, and -3). For Si I including the collisions with HI leads to the establishment of equilibrium populations in the spectral line formation region even in hot metal-deficient models and to vanishingly small departures from LTE in spectral lines.

  15. L'impact des oiseaux granivores sur les cultures céréalières dans le delta central du Niger au Mali

    Directory of Open Access Journals (Sweden)

    Billiet, F.

    1983-01-01

    Full Text Available The impact of granivorous birds on cereal farming in the central delta of Niger river in Mali. Masses of granivorous birds destroy about 5-10 % of the rice crop produced in the central Niger delta. To the local species (ducks, ploceid birds and the quelea, which is the most abundant and noxious pest with numbers ranging from 18 million in January to 10 million in May-June add palearctic migratory birds, which are mainly ducks and stilt-birds. Bird control is necessarily undertaken but is inefficient due to the vastness of the region, difficult access to the sites, the number of birds and insufficient financial means.

  16. La statue de Simon Bolivar ou l’aliénation de l’histoire par le héros national

    OpenAIRE

    Cabeza, Éveline

    2016-01-01

    Un personnage est toujours présent dans la vie publique et quotidienne des peuples du Vénézuela et de la Colombie. Il est curieux de voir se répéter inlassablement, dans la géographie des places publiques des villages comme des cités, une certaine organisation culturelle de l’espace ; la ville « moderne » a une place publique carrée ; les quatre côtés du carré sont occupés par l’église, la maison du gouvernement avec une dépendance militaire, la banque, quelques demeures de notables ou des ma...

  17. S tatu s a n dC omparativ e An aly sis of Overseas Upstream Businesses of China'sOil Majors%S tatu s a n dC omparativ e An aly sis of Overseas Upstream Businesses of China'sOil Majors

    Institute of Scientific and Technical Information of China (English)

    LiYushun

    2012-01-01

    In recent years, China's three oil majors has taken .the opportunity of rising oil price and financialcrisis, implemented the "going out" strategy and done international businesses. They have been actively engaged in overseas oil/gas development and petroleum engineering services. They have completed market existence in overseas upstream business successively and their overseas upstream business is on a fast track of development.

  18. BORÇALI VE ÇILDIR KARAPAPAK / TEREKEME AĞZI SÖZ VARLIĞININ ALINTI SÖZCÜKLER AÇISINDAN KARŞILAŞTIRILMASI / THE COMPARISON OF QUOTED WORDS IN BORÇALI AND ÇILDIR KARAPAPAK / TEREKEME DIALECT

    Directory of Open Access Journals (Sweden)

    Bahadır GÜNEŞ

    2015-09-01

    Full Text Available Bu çalışmada Borçalı ve Çıldır Karapapak / Terekeme ağzındaki alıntı sözcükler, ilgili yörelerden tarafımızca ses kayıt cihazı yardımıyla ve not alarak derlenen metinlerden hareketle karşılaştırmalı olarak gösterilecektir. Bunun yapılmasındaki en önemli neden, söz konusu çalışmanın eş zamanlı ve karşılaştırmalı olmasıdır. Bu nedenle aynı zaman diliminde derlenen metinlerden yararlanılmıştır. Bir başka deyişle ilgili yörelerden daha önce derlenen metinlerin söz varlığına burada yer verilmemiştir. Bu çalışma, anılan yörelerin söz varlığını bütünüyle ortaya koyma iddiası taşımamaktadır. Aynı kökene sahip Türklerin farklı coğrafya, kültür, siyasi ve sosyal alanlarda varlık gösteren ağızlarındaki söz varlığının eş zamanlı ve karşılaştırmalı olarak nasıl bir sonuç vereceğine dair bir ipucu elde etme düşüncesi hâkimdir. / In this study Borçalı and Çıldır Karapapak / Terekeme quoted words will be shown in comparison related places by us with the help of voice recorder and taking notes compiled text of the support. The study simultaneously and is comparatively the most important reason for this. Therefore, it is used also compiled texts. That does not existence of an earlier text. This study does not specify all of the vocabulary of the places. Karapapak / Terekeme Turkish different geographies, cultures, simultaneously indicating the presence of vocabulary in the dialect in political and social fields and the idea that how to get a result as compared.

  19. Droop-free AlxGa1-xN/AlyGa1-yN quantum-disks-in-nanowires ultraviolet LED emitting at 337 nm on metal/silicon substrates

    KAUST Repository

    Janjua, Bilal

    2017-01-18

    Currently the AlGaN-based ultraviolet (UV) solid-state lighting research suffers from numerous challenges. In particular, low internal quantum efficiency, low extraction efficiency, inefficient doping, large polarization fields, and high dislocation density epitaxy constitute bottlenecks in realizing high power devices. Despite the clear advantage of quantum-confinement nanostructure, it has not been widely utilized in AlGaN-based nanowires. Here we utilize the self-assembled nanowires (NWs) with embedding quantum-disks (Qdisks) to mitigate these issues, and achieve UV emission of 337 nm at 32 A/cm (80 mA in 0.5 × 0.5 mm device), a turn-on voltage of ∼5.5 V and droop-free behavior up to 120 A/cm of injection current. The device was grown on a titanium-coated n-type silicon substrate, to improve current injection and heat dissipation. A narrow linewidth of 11.7 nm in the electroluminescence spectrum and a strong wavefunctions overlap factor of 42% confirm strong quantum confinement within uniformly formed AlGaN/AlGaN Qdisks, verified using transmission electron microscopy (TEM). The nitride-based UV nanowires light-emitting diodes (NWs-LEDs) grown on low cost and scalable metal/silicon template substrate, offers a scalable, environment friendly and low cost solution for numerous applications, such as solid-state lighting, spectroscopy, medical science and security.

  20. La littérature francophone des Caraïbes, entre aliénation et déception identitaire: l´exemple de la Traversée de la Mangrove de Maryse Condé

    OpenAIRE

    2016-01-01

    Les Caraïbes ont une place particulière dans la littérature francophone. Que ce soit avec le mouvement de la négritude avec Aimé Césaire ou la poétique de la relation, cette littérature est centrée sur un style métissé entre l’usage de langues vernaculaires et le choix du français comme langue d’écriture. Les traumatismes coloniaux perdurent dans cette littérature avec une conception quasi ontologique de la bâtardise signifiant de manière allégorique cette quête impossible d’une origine. La t...

  1. 基于现代DSP技术的全数字MQAM调制器的设计%Design of Ali-digitized MQAM Modulator Based on Modern DSP Technology

    Institute of Scientific and Technical Information of China (English)

    董明佶

    2011-01-01

    利用MQAM调制的基本原理,采用基于ISE DS的System Generator工具,设计了一个基于FPGA的多进制QAM调制器,在给出了系统设计框图后,重点介绍了扰码器、差分编码器、星座映射单元、nR成形滤波器等模块的设计方法,实现了64QAM的基带调制和中频处理,最终在FPGA上予以实现.%According to the ultimate principle of the MQAM modulation, the tool of System Generator in ISE DS is used to design a multimode QAM modulator based on FPGA. After the system design schematic is given, some units are specified, including scrambler, serial to parallel, differential encoding, mapping, and shaping filter, etc. Then, the 64QAM baseband modulation and IF design are realized. The QAM modulator is ultimately implemented on the FPGA device.

  2. Virtual Private Cloud (VPC)Desig of Gansu Radio and Television Ali Cloud Platformn%甘肃广电阿里飞天云平台专有云(V PC)设计方案

    Institute of Scientific and Technical Information of China (English)

    赵鸿志; 刘志贵; 赵亦璇

    2016-01-01

    在云计算的应用中,本地政企单位信息化系统从传统架构至云架构必将经历一个过渡阶段,由于现阶段公有云不会成为本地政企的首要选择,从云计算是一种服务的本质来看,私有云并不符合云计算的商业模式,甘肃广电专有云(VPC )作为混合云(传统架构和云架构并存)的最佳方案,充分满足了本地政企客户的云计算服务需求。%In cloud computing application,the information systems of local government and enterprises must spend a period transiting from the traditional architecture to the cloud framework.Since the present public cloud will not become the first choice of the local government and enterprise,and the essence of cloud compu-ting is a service,a private cloud does not comply with the business model of cloud computing.Thus as the op-timal scheme of a hybrid cloud architechture (co-existence of traditional architecture and Cloud Architecture), VPC of Gansu Radio and Television fully meets the demand for cloud computing services of local government enterprise customer.

  3. On the crystal energy and structure of A{sub 2}Ti{sub n}O{sub 2n+1} (A=Li, Na, K) titanates by DFT calculations and neutron diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Catti, Michele, E-mail: catti@mater.unimib.it [Dipartimento di Scienza dei Materiali, Università di Milano Bicocca, Via Cozzi 53, 20125 Milano (Italy); Pinus, Ilya [Dipartimento di Scienza dei Materiali, Università di Milano Bicocca, Via Cozzi 53, 20125 Milano (Italy); Scherillo, Antonella [ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton, Didcot, Oxon, OX11 0QX (United Kingdom)

    2013-09-15

    First-principles quantum-mechanical calculations (CRYSTAL09 code, B3LYP functional) were performed on alkali titanates A{sub 2}Ti{sub n}O{sub 2n+1} with layered structure (n=3,4,6). Monoclinic structural types with unshifted (P2{sub 1}/m) and with shifted (C2/m) layers were considered. Crystal energies and full structural details were obtained for all Li, Na, and K phases. Neutron diffraction data were collected on powder samples of P2{sub 1}/m-Li{sub 2}Ti{sub 3}O{sub 7} (a=9.3146(3), b=3.7522(1), c=7.5447(3) Å, β=97.611(4)°) and C2/m-K{sub 2}Ti{sub 4}O{sub 9} (a=18.2578(8), b=3.79160(9), c=12.0242(4) Å, β=106.459(4)°) and their structures were Rietveld-refined. Computed energies show the P2{sub 1}/m arrangement as favoured over the C2/m one for n=3, and the opposite holds for n=6. In the n=4 case the P2{sub 1}/m configuration is predicted to be more stable for Li and Na, and the C2/m one for K titanates. Analysis of Li–O and K–O crystal-chemical environments from experiment and theory shows that the alkali atom bonding is stabilized/destabilized in the different phases consistently with the energy trend. - Graphical abstract: Display Omitted - Highlights: • The P2{sub 1}/m structure-type is found to be more stable for A{sub 2}Ti{sub 3}O{sub 7} layer titanates. • The C2/m structure-type is found to be more stable for A{sub 2}Ti{sub 6}O{sub 13} layer titanates. • Tetratitanates are predicted to prefer the P2{sub 1}/m (Li and Na) or C2/m (K) structure. • Li–O and K–O bond distances follow a trend consistent with computed phase energies.

  4. Vibration Spectra of Quasi-confined Optical Phonon Modes in an Asymmetric Wurtzite AlxGa1-xN/GaN/AlyGa1-yN Quantum Well

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li; SHI Jun-Jie

    2007-01-01

    Based on the dielectric continuum model and Loudon's uniaxial crystal model,the properties of the quasiconfined (QC) optical phonon dispersions and the electron-QC phonons coupling functions in an asymmetric wurtzite quantum well (QW) are deduced via the method of electrostatic potential expanding.The present theoretical scheme can naturally reduce to the results in symmetric wurtzite QW once a set of symmetric structural parameters are chosen.Numerical calculations on an asymmetric A1N/GaN/Al0.15Ga0.85N wurtzite QW are performed.A detailed comparison with the symmetric wurtzite QW was also performed.The results show that the structural asymmetry of wurtzite QW changes greatly the dispersion frequencies and the electrostatic potential distributions of the QC optical phonon modes.

  5. deSiertoS de aliMentoS. aProXiMaCioneS ConCePtUaleS al eStUdio JURÍDICO DEL PROBLEMA DEL HAMBRE

    Directory of Open Access Journals (Sweden)

    Cesar Augusto Molina Saldarriaga

    2014-12-01

    Full Text Available La protección del Derecho a la Alimentación en el contexto colombiano no ha sido clara. La naturaleza del derecho y sus ámbitos de protección obligan a estudiar estrategias que superen las visiones unidimensionales de la disciplina jurídica en su reconocimiento, protección y garantía. Los estudios sobre el fenómeno alimentario han dado lugar al surgimiento del concepto Desiertos de Alimentos. Este ofrece puntos de reflexión importantes en relación con el Derecho a la Alimentación; sin embargo, en Colombia los estudios desde él son inexistentes. A partir de un levantamiento del estado del arte sobre Desiertos de Alimentos se analiza su relación con el Derecho a laAlimentación, con el objeto de determinar la importancia de los es- tudios y estrategias de atención holísticos e interdisciplinares desde el derecho para atender las problemáticas alimentarias. Se concluye que los fenómenos alimentarios son complejos, requieren aproximaciones multidimensionales y la transformación de la cultura jurídica para atenderlos.

  6. Advancing Glaciological Applications of Remote Sensing with EO-1: (1) Mapping Snow Grain Size and Albedo on the Greenland Ice Sheet Using an Imaging Spectrometer, and (2) ALI Evaluation for Subtle Surface Topographic Mapping via Shape-from Shading

    Science.gov (United States)

    2003-01-01

    The Hyperion sensor, onboard NASA's Earth Observing-1 (EO-1) satellite,is an imaging spectroradiometer with 220 spectral bands over the spectral range from 0.4 - 2.5 microns. Over the course of summer 2001, the instrument acquired numerous images over the Greenland ice sheet. Our main motivation is to develop an accurate and robust approach for measuring the broadband albedo of snow from satellites. Satellite-derived estimates of broadband have typically been plagued with three problems: errors resulting from inaccurate atmospheric correction, particularly in the visible wavelengths from the conversion of reflectance to albedo (accounting for snow BRDE); and errors resulting from regression-based approaches used to convert narrowband albedo to broadband albedo. A typerspectral method has been developed that substantially reduces these three main sources of error and produces highly accurate estimates of snow albedo. This technique uses hyperspectral data from 0.98 - 1.06 microns, spanning a spectral absorption feature centered at 1.03 microns. A key aspect of this work is that this spectral range is within an atmospheric transmission window and reflectances are largely unaffected by atmospheric aerosols, water vapor, or ozone. In this investigation, we make broadband albedo measurements at four sites on the Greenland ice sheet: Summit, a high altitude station in central Greenland; the ETH/CU camp, a camp on the equilibrium line in western Greenland; Crawford Point, a site located between Summit and the ETH/CU camp; and Tunu, a site located in northeastern Greenland at 2000 m. altitude. Each of these sites has an automated weather station (AWS) that continually measures broadband albedo thereby providing validation data.

  7. Examination of nutrition habits of high school students 14-18 age14-18 yaş lise öğrencilerinin beslenme alişkanliklarının incelenmesi

    Directory of Open Access Journals (Sweden)

    Mutlu Ildız

    2015-05-01

    Full Text Available The aim of the study is to examine eating habits of high school students ages 14-18. A total of 610 (313 girls, 297 boys volunteer students who is attending in high schools in Denizli, participated in the study. Eating habits were determined by dietary questionnaire which consisting of 10 questions. Statistical calculations were performed with SPSS. To find differences by gender chi-square test were applied. In the event of P values less than 0.05 between-group differences and relationships between variables were considered significant.It was found that p<0.01 level of significant difference between the boys and girls given responses to “Do you always eat your breakfast?”. In the other age groups there was no significant difference.  66.0% of male high school students and 64.9% of the female high school students who participated to survey stated that they hadn’t skipped their lunch with always having their lunch. Whereas at the dinner as a very large majority like 93.3% of boys and 86.6% girls stated that they had always consumed their meals regularly.As a result, it can be say that breakfast is the meal that mostly skipped by adolescent students at the age 14-18 and they haven’t regular eating habit and depending on gender there are some changes in eating habits.Özet:Bu çalışma, 14-18 yaş lise öğrencilerinin beslenme alışkanlıklarının incelenmesi amacıyla yapılmıştır. Bu çalışmaya Denizli ili merkez liselerde öğrenim gören 313 kız, 297 erkek olmak üzere toplam 610 gönüllü öğrenci katılmıştır. Çalışmanın yöntemsel modeli tarama yöntemi olup, katılımcılara beslenme alışkanlıklarını öğrenebilmek için 10 sorudan oluşan beslenme anketi uygulanmıştır. İstatiksel hesaplamalar SPSS programında yapılmıştır. Cinsiyetlere göre farkı bulmak için ki kare testi uygulanmıştır. P değerinin 0,05’ten küçük olması durumunda gruplar arası fark ve değişkenler arası ilişki anlamlı kabul edilmiştir.Erkek ve kız lise öğrencilerinin sabah öğünlerinizi her zaman yer misiniz? sorusuna verdikleri cevaplar arasında p<0,01 düzeyinde anlamlı fark bulunmuştur. Diğer yaş gruplarında ise anlamlı farklılığa rastlanmamıştır. Araştırmaya katılan erkek lise öğrencilerinin %66.0’sı, kızların ise %64.9’u öğle yemeklerini her zaman yiyerek öğle öğününü atlamadıklarını belirtmişlerdir. Akşam öğününde ise erkeklerde %93.3, kızlarda ise %86.6 gibi çok büyük bir çoğunluk her zaman öğünü düzenli olarak tükettiklerini belirtmişlerdir.Sonuç olarak, 14-18 yaş adölesan öğrencilerin en çok atladıkları öğünün kahvaltı olduğu, beslenme alışkanlıklarının düzenli olmadığı, cinsiyete bağlı beslenme alışkanlıklarında değişiklikler meydana geldiği söylenebilir.

  8. 双排龈技术在CAD/CAM全瓷修复中的临床应用%Clinical application of double gingival retraction technique for ali- ceramic restorations of CAD / CAM.

    Institute of Scientific and Technical Information of China (English)

    孙珍; 许晓波; 边华琴

    2011-01-01

    Objection: To evaluate double gingival retraction technique of all-ceramic restorations in CAD/CAM.Method: 30 patients,48 restorations in CAD/CAM were used with double gingival retraction technique, observed gingival、prepared tooth, digital impression and all-ceramic restoration. Result: The rates of satisfaction with double gingival retraction were 97.91%,95.83 % and 100 %. Conclusion:Double gingival retraction technique was an effective method in CAD/CAM restoration.%目的:评价双排龈技术在CAD/CAM全瓷修复中的临床应用效果.方法:对30例48单位前牙行CAD/CAM全瓷修复,牙体预备后采用双排龈技术进行排龈,检查牙龈及预备体、光学印模以及修复体边缘情况.结果:双排龈技术的满意率分别为97.91%,95.83%,100.0%.结论:双排龈技术在CAD/CAM全瓷修复时具有很好的应用效果.

  9. Etude d'un revêtement d'acier inoxydable Z 2 CND 18-12 réalisé sur un acier doux, sous irradiation laser avec injection de poudre coaxiale au faisceau

    OpenAIRE

    FOUQUET, F; Sallamand, P.; Dierickx, P.; Bonne, D.; Millet, J.

    1994-01-01

    Le présent travail traite du dépôt d'acier inoxydable austénitique de type AISI 316 L sur acier doux par projection de poudre sous faisceau laser et de la caractérisation du revêtement élaboré. Les revêtements obtenus par cette technique sont de bonne qualité, exempts de fissures, avec peu de porosités et parfaitement adhérents au substrat. Leur microstructure très fine est dendritique ou cellulaire. La structure est apparue majoritairement austénitique, mais avec présence non négligeable de ...

  10. Rändeandmete kvaliteet ja rändesuundumused Eestis aastatel 2000-2005 = The quality of migration data and the trends of migration in Estonia in 2000-2005 / Alis Tammur, Tiit Tammaru, Ene- Margit Tiit

    Index Scriptorium Estoniae

    Tammur, Alis

    2006-01-01

    Eesti statistilise rahvastikuarvestuse alus on olnud viimase rahvaloenduse rahvaarv, millele lisatakse omavalitsusüksuste kaupa registripõhiselt kogutavad sünnid, surmad ning sisse- ja väljaränne. Rahvaloenduse ja rahvastikuregistri andmete põhimõtteline erinevus. Sise- ja välisrände arvestamise probleemid, rändesuundumuste analüüs. Diagramm. Tabelid

  11. Diversifier les rotations céréalières notamment avec du pois et du colza – Données récentes d’expérimentations et d’études

    Directory of Open Access Journals (Sweden)

    Schneider Anne

    2010-09-01

    Full Text Available Simplification has been a clear trend in the composition of French crop rotations in the past decades, whereas agronomic knowledge proves the interest of diversification in order to benefit from the so called “preceding effects” and “cumulative effects”. It is needed to study the possible input of crops such as rape seed or pea for the cereal-based rotations in agronomic terms but also in economic and environmental terms. The first step is to quantify the impacts specifically due to the change in crop succession composition, and afterwards to allocate an objective economic value to them so that they are easy to integrate into comparisons of production systems. The regional case studies of a current multi-partner project enable to illustrate the economic and environmental evaluation of alternatives to the rotation “Oilseed rape – Wheat – Barley”. In addition, the recent field experiment data of this project (farm tests or experimental trials provide technical and scientific elements on technical feasibility and the economic performance of the innovative succession “pea before rape seed”, but also on the interest of the introduction of symbiotically fixed nitrogen in crop rotations in order to decrease the negative environmental impacts of mineral fertilisers-based systems. Diversification of crops and nitrogen fixation appear to be two key elements for (i competitiveness, when at least the agronomic effects are taken into account, and (ii sustainable systems, when one considers the preservation of farm potential and of the environment.

  12. 从阿里平台看农产品电子商务发展趋势%The Development Trend of Agricultural Products E-business from the Perspective of Ali Platform

    Institute of Scientific and Technical Information of China (English)

    陈亮

    2015-01-01

    当前,电子商务发展呈现无线化、全球化、娱乐化、线上线下一体化、农村发力、大数据作用凸显等趋势。农产品电子商务发展也出现如下几个新特点:一是通过互联网用心做农业的“新农人”崛起;二是原产地农产品直销成为热点;三是越来越多的海外农产品涌进中国;四是生鲜农产品电子商务快速发展;五是非标准化农产品探索新标准;六是农产品成为县域电子商务的关键抓手,一些特点明显的县域电子商务模式不断涌现。%At present,the development of e-business is demonstrating the characteristics of wireless,global,entertaining, online and offline integrated,the rising force in rural areas,and the highlighted big data. And some new features of e-business of agricultural products existed:first,the rising of“new farmers”who doing agriculture related business through internet;second, the hot direct sell of agricultural products from areas of origin;third,more and more imported agricultural products;fourth,the rapid developing e-business of fresh agricultural products;fifth,exploring new standard for non standard agricultural products;and sixth,agricultural products as the focus of e-business in county areas.

  13. Résistance culturelle et “Révolution nationale” pétainiste: Les Mouches de Jean-Paul Sartre comme dénonciation d’une religion aliénante sous la France de Vichy

    Directory of Open Access Journals (Sweden)

    Nathalie Stevens

    2009-12-01

    Full Text Available Este artículo analiza de qué manera Jean-Paul Sartre utilizó el teatro –y notablemente su primera obra Les Mouches- para criticar el régimen de Vichy y su instrumentalización de las creencias religiosas a fin de someter y dominar a la población francesa. Él no sólo quiso ilustrar la conveniente relación entre la Iglesia y el poder sino también mostrar las posibilidades con que contaban los intelectuales franceses para luchar contra la dominación de Vichy, la censura y las represalias de los adversarios políticos.___________________ABSTRACT:This paper analyses the way in which Jean-Paul Sartre used the theatre – and outstandingly, his first play Les Mouches - to criticise the regime of Vichy and the way it exploited religious beliefs in order to subjugate and dominate the French population. Not only did he manage to illustrate the convenient relationship between the Church and the power, but also showed how the French intellectuals were able to fight against the domination of Vichy, the censorship and the reprisals against political adversaries.

  14. Exploitation du consommateur et aliénation du client: la sphère domestique comme espace de création de valeur économique et symbolique

    Directory of Open Access Journals (Sweden)

    Perronet, Alexandra

    2006-07-01

    Full Text Available La phase actuelle d’accumulation capitalistique tend à faire de la consommation non seulement une sphère de reproduction des rapports sociaux, mais un lieu de production des forces de travail. Partant de ce postulat, cet article se propose de montrer comment les pratiques de consommation structurent les rapports sociaux de production. Selon l’auteur, il s'agit d'une question à la fois pratique et symbolique : la consommation déterminant tant l'organisation des rapports sociaux que le développement d'un imaginaire social.

  15. Exploitation du consommateur et aliénation du client. La sphère domestique comme espace de création de valeur économique et symbolique

    Directory of Open Access Journals (Sweden)

    Alexandra Perronet

    2006-07-01

    Full Text Available La phase actuelle d’accumulation capitalistique tend à faire de la consommation non seulement une sphère de reproduction des rapports sociaux, mais un lieu de production des forces de travail. Partant de ce postulat, cet article se propose de montrer comment les pratiques de consommation structurent les rapports sociaux de production. Selon l’auteur, il s’agit d’une question à la fois pratique et symbolique : la consommation détermine tant l’organisation des rapports sociaux que le développement d’un imaginaire social.

  16. An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant.

    Science.gov (United States)

    Zhong, Huailing; Hansen, Kasper B; Boyle, Noel J; Han, Kiho; Muske, Galina; Huang, Xinyan; Egebjerg, Jan; Sánchez, Connie

    2009-10-25

    The human serotonin transporter (hSERT) has primary and allosteric binding sites for escitalopram and R-citalopram. Previous studies have established that the interaction of these two compounds at a low affinity allosteric binding site of hSERT can affect the dissociation of [(3)H]escitalopram from hSERT. The allosteric binding site involves a series of residues in the 10th, 11th, and 12th trans-membrane domains of hSERT. The low affinity allosteric activities of escitalopram and R-citalopram are essentially eliminated in a mutant hSERT with changes in some of these residues, namely A505V, L506F, I507L, S574T, I575T, as measured in dissociation binding studies. We confirm that in association binding experiments, R-citalopram at clinically relevant concentrations reduces the association rate of [(3)H]escitalopram as a ligand to wild type hSERT. We demonstrate that the ability of R-citalopram to reduce the association rate of escitalopram is also abolished in the mutant hSERT (A505V, L506F, I507L, S574T, I575T), along with the expected disruption the low affinity allosteric function on dissociation binding. This suggests that the allosteric binding site mediates both the low affinity and higher affinity interactions between R-citalopram, escitalopram, and hSERT. Our data add an additional structural basis for the different efficacies of escitalopram compared to racemic citalopram reported in animal studies and clinical trials, and substantiate the hypothesis that hSERT has complex allosteric mechanisms underlying the unexplained in vivo activities of its inhibitors.

  17. Ekphrasis : au lieu de décrire ce qu’ils voyaient, ils réalisèrent ce qui était décrit

    Directory of Open Access Journals (Sweden)

    Ana Vanessa Lucena

    2014-04-01

    Full Text Available Cette contribution s’insère dans le domaine des recherches actuelles en didactique des arts visuels mettant en évidence les pratiques de la réception des œuvres. Elle rend compte d’un projet d’apprentissage artistique prenant comme matière la collection René et Madeleine Junod et pratiquée durant quatre mois de leçons hebdomadaires dans deux classes de 7e maturité d’une école publique de la ville de La Chaux-de-Fonds en Suisse. Le projet a été vécu en trois parties : un exercice d’ekphrasis et de reproduction par la méthode de la grille de copie en salle de classe, une série de « jeux de stimulation de l’observation » pendant une visite au musée, complétée par les activités de dessin et coloriage à la maison et en salle de classe. Cet article est centré sur le premier exercice de « l’ekphrasis » où il a été proposé aux élèves la description de quatre tableaux de styles, thèmes et artistes différents. Chaque descriptif posait des contraintes en termes de composition des images et d’interprétation d’un vocabulaire spécifique aux arts visuels. Ekphrasis: Instead of describing what they were seeing, they created what was described This contribution goes into the domain of current research in Visual Arts didactics putting in evidence the methods of the “réception d’œuvre”. It reports an artistic learning project based on René and Madeleine Junod’s collection and practiced during four month of weekly Visual Arts lessons in two 7th grade classes of a public school in the city of La Chaux-de-Fonds, Switzerland. The project was built in three parts: an “ekphrasis” activity, which implies describing by words a few paintings of the collection, then copying them using the “grille de copie” method; a few “games of observation skills stimulation” during the visit of a museum, then reinforced and completed by the “painting and drawing activities” at home and in the classroom. This article focuses only on the first exercise of the “ekphrasis” in which four paintings descriptions, all of different styles, themes and artists, were given to the students. Each description setting represented a constraint in terms of images composition and interpretation of a specific Visual Arts vocabulary.

  18. Etablissement de scénarios alternatifs de valorisations alimentaires et non alimentaires des ressources céréalières wallonnes à l'horizon 2030

    Directory of Open Access Journals (Sweden)

    Van Stappen, F.

    2014-01-01

    Full Text Available Alternative scenarios for food and non-food uses of Walloon cereals by 2030. Topic. Based on the current uses of cereals grown in Wallonia (Belgium, various scenarios defining possible futures for the Walloon cereal sector have been created. Purpose. These scenarios lay the basis for research aiming at assessing the sustainability of food and non-food uses of cereals. Method. Based on contrasted hypotheses, four scenarios for the uses of Walloon cereals by 2030 have been defined with the support of stakeholders involved in all the steps of the chain. Results. The first scenario, called "Business-as-Usual", extrapolates trends from 15 years before 2010 and up to 2030. In the second scenario, called "Strategic", the current system is optimized from the environmental, economic and social point of view. The third and fourth scenarios break with current trends. The third scenario, called "Localization", considers an increased autonomy and the development of new cereal processing units in Wallonia. The fourth scenario, called "Globalization", focuses on a massive level of cereal export in response to an increasing demand from the global market and deals with high added-value products within Wallonia. Conclusions. Issues such as competition between food uses and non-food uses of cereals and of Walloon dependency on imports are addressed in these scenarios illustrating possible future situations, from food self-sufficiency to dramatic globalization, through the development of new outlets combining the adaptation of cropping practices, consumption, the evolution of habits and the use of new technologies.

  19. The value of nitrogen washout/washin method in assessing alveolar recruitment volume in acute lung injury patients

    Institute of Scientific and Technical Information of China (English)

    李洋

    2013-01-01

    Objective To evaluate the precision and feasibility of nitrogen washout/washin method in assessing lung recruitment of acute lung injury(ALI)patients.Methods Fifteen ALI patients underwent mechanical ventilation

  20. Ulster Medical Society Junior Members Forum Thursday 12th December 2013

    OpenAIRE

    Boyle, AJ; Digangi, A; Mottram, LJ; Hamid, U; McNamee, L; G. White; Cross, LJM; McNamee, J; O'Kane, C; McAuley, DM; Kennedy, F.; Russell, A; Smithson, WH; Parsons, L.; Robertson, I.

    2016-01-01

    Introduction Platelet activation has a role in the pathogenesis of acute lung injury (ALI). Observational data suggests aspirin treatment may prevent the development of ALI in critically ill patients. However, it is unknown if aspirin usage alters outcomes in patients with established ALI. Methods All patients with ALI were identified prospectively in a single large regional medical and surgical Intensive Care Unit (ICU) between December 2010 and July 2012. Demographic, clinical, and laborato...

  1. Alginate lyases from alginate-degrading Vibrio splendidus 12B01 are endolytic.

    Science.gov (United States)

    Badur, Ahmet H; Jagtap, Sujit Sadashiv; Yalamanchili, Geethika; Lee, Jung-Kul; Zhao, Huimin; Rao, Christopher V

    2015-03-01

    Alginate lyases are enzymes that degrade alginate through β-elimination of the glycosidic bond into smaller oligomers. We investigated the alginate lyases from Vibrio splendidus 12B01, a marine bacterioplankton species that can grow on alginate as its sole carbon source. We identified, purified, and characterized four polysaccharide lyase family 7 alginates lyases, AlyA, AlyB, AlyD, and AlyE, from V. splendidus 12B01. The four lyases were found to have optimal activity between pH 7.5 and 8.5 and at 20 to 25°C, consistent with their use in a marine environment. AlyA, AlyB, AlyD, and AlyE were found to exhibit a turnover number (kcat) for alginate of 0.60 ± 0.02 s(-1), 3.7 ± 0.3 s(-1), 4.5 ± 0.5 s(-1), and 7.1 ± 0.2 s(-1), respectively. The Km values of AlyA, AlyB, AlyD, and AlyE toward alginate were 36 ± 7 μM, 22 ± 5 μM, 60 ± 2 μM, and 123 ± 6 μM, respectively. AlyA and AlyB were found principally to cleave the β-1,4 bonds between β-d-mannuronate and α-l-guluronate and subunits; AlyD and AlyE were found to principally cleave the α-1,4 bonds involving α-l-guluronate subunits. The four alginate lyases degrade alginate into longer chains of oligomers.

  2. Soluble Endothelial Selectin in Acute Lung Injury Complicated by Severe Pneumonia

    Directory of Open Access Journals (Sweden)

    Daisuke Osaka, Yoko Shibata, Kazunori Kanouchi, Michiko Nishiwaki, Tomomi Kimura, Hiroyuki Kishi, Shuichi Abe, Sumito Inoue, Yoshikane Tokairin, Akira Igarashi, Keiko Yamauchi, Yasuko Aida, Takako Nemoto, Keiko Nunomiya, Koji Fukuzaki, Isao Kubota

    2011-01-01

    Full Text Available Background: Pneumonia is still one of the most frequent causes of death in the elderly. Complication of acute lung injury (ALI/acute respiratory distress syndrome (ARDS by pneumonia makes patients very ill due to severe respiratory failure. Biomarkers that can discriminate the presence of complicating ALI/ARDS are required for early detection. The aim of this research was to investigate whether soluble endothelial selectin (sES could be a biomarker for ALI.Methods: Serum sES levels were measured in 27 pneumonia patients, who were enrolled between April 2006 and September 2007. Among these patients, six had ALI or a condition that was clinically comparable to ALI (cALI. All patients who were enrolled were successfully treated and survived.Results: Circulating sES levels were elevated in pneumonia patients with ALI/cALI, and sES levels decreased following treatment of their pneumonia. Univariate and multivariate logistic regression analyses showed that sES was the only significant factor for identifying complicating ALI/cALI, independently of C-reactive protein (CRP and lactate dehydrogenase (LDH. By receiver operating characteristic (ROC curve analysis, the cut-off value for sES was 40.1 ng/mL, with a sensitivity of 0.8 and a specificity of 0.8.Conclusion: sES may be a useful biomarker for discriminating complicating ALI/cALI in patients with severe pneumonia.

  3. Ascertainment of acute liver injury in two European primary care databases

    NARCIS (Netherlands)

    Ruigómez, A.; Brauer, R.; Rodríguez, L. A García; Huerta, C.; Requena, G.; Gil, M.; de Abajo, Francisco; Downey, G.; Bate, A.; Tepie, M. Feudjo; de Groot, M.C.H.; Schlienger, R.; Reynolds, R.; Klungel, O.

    2014-01-01

    Purpose The purpose of this study was to ascertain acute liver injury (ALI) in primary care databases using different computer algorithms. The aim of this investigation was to study and compare the incidence of ALI in different primary care databases and using different definitions of ALI. Methods T

  4. Analysis on the Scenery Characteristic and the Influence Element of the Tularemia Natural Focus in Ali,Tibet%西藏阿里野兔热自然疫源地景观特征和影响因素分析

    Institute of Scientific and Technical Information of China (English)

    党荣理; 周新荣; 王天祥; 张桂林; 吉宝新; 窦君

    2000-01-01

    本文分析了西藏阿里野兔热自然疫源地景观特征和影响因素,着重探讨了自然疫源地存在的客观条件及其与自然疫源性疾病的内在关系,为该地区野兔热自然疫源地的深入研究和防治提供参考.

  5. La lixiviation d’azote nitrique dans les rotations céréalières avec colza : un diagnostic à partir de l’analyse de résultats d’expérimentations pluriannuelles et de modélisations

    Directory of Open Access Journals (Sweden)

    Reau Raymond

    2006-11-01

    Full Text Available Nitrate leaching was measured during 6 years in a crop rotation including oilseed rape (OSR and winter wheat in two field trials, on two rendzina soils differing by their water content, in Le Magneraud (West of France and Martincourt (East of France. Results show that nitrate losses are variable within the year and drainage: between 20 and 95 kgN.ha–1.an–1. When the soil remains without cover crop after OSR, losses under wheat following OSR are definitely higher than under OSR following wheat: respectively 54.1 kgN.ha–1.an–1 and 14.8 kgN.ha–1.an–1 during the first three years in Le Magneraud. Results even show that nitrate losses differed according to N strategy management. Among the treatments of nitrogen management, the least losses are observed with optimized fertilization plus OSR volunteers used as cover crop between OSR and wheat; and the highest losses are observed with high fertilization without OSR volunteers as catch crop : respectively in Le Magneraud (second phases of three years 29.9 and 61.1 kgN.ha–1.an–1, and at Martincourt 43.0 and 61.4 kgN.ha–1.an–1 on average. Simulations realized with LIXIM and DEAC models for new years, soils and regions, show the same trend that experimental results: nitrate losses are higher under wheat after OSR, and the high performance cropping systems are based on optimized N fertilization management of OSR and the catch of nitrate at the end of summer by OSR (after wheat or its volunteers (before wheat.

  6. « Le plus beau rêve réalisé » “ The most beautiful dream has come true ”: The ’Journal of Salonique’ and the Young Turks 1rst July 1908-30th June 1909

    Directory of Open Access Journals (Sweden)

    Joëlle Dalègre

    2012-05-01

    Full Text Available Le « Journal de Salonique », francophone et francophile, salue avec enthousiasme la Révolution Jeune-Turque à Salonique. Fidèle aux idéaux de la Révolution Française, il assure un soutien indéfectible aux Jeunes-Turcs en qui il place tous ses espoirs pour un nouvel Empire ottoman. Saadi et Samuel Levy en font un journal riche en informations à la fois sur la vie de Salonique et sur les nouveautés politiques. Il s’oppose également aux sionistes, jugeant que Salonique est, pour un Juif, le meilleur endroit de la terre et il invite les organisations juives à investir dans les tchifliks de Macédoine pour y établir les Juifs chassés d’Europe orientale par les pogroms.The “ Journal de Salonique ”, a French speaking and France loving newspaper, welcomes the revolution of the Young Turks on Thessaloniki with great enthusiasm. Faithful to the ideals of the French Revolution, it provided strong support to the Young Turks in which it places its hopes for a new Ottoman Empire. Saadi and Samuel Levy have given us a newspaper rich in information regarding the life of Thessaloniki and political novelty. It was opposed to the Zionists,maintaining the notion that Thessaloniki is the best place on earth for a Jew. So, the newspaper invited Jewish organizations to invest in tchifliks in Macedonia, in order to establish there the Jews who were expelled from eastern Europe by the pogroms.

  7. Translation into Turkish of: “Changes to publication requirements made at the XVIII International Botanical Congress in Melbourne – what does e-publication mean for you?”. Translated by Ali A. Dönmez, Yusuf Menemen and Zübeyde Uğurlu

    Directory of Open Access Journals (Sweden)

    Sandra Knapp

    2012-03-01

    Full Text Available Changes to the International Code of Botanical Nomenclature are decided on every 6 years at Nomenclature Sections associated with International Botanical Congresses (IBC. The XVIII IBC was held in Melbourne, Australia; the Nomenclature Section met on 18-22 July 2011 and its decisions were accepted by the Congress at its plenary session on 30 July. Several important changes were made to the Code as a result of this meeting that will affect publication of new names. Two of these changes will come into effect on 1 January 2012, some months before the Melbourne Code is published. Electronic material published online in Portable Document Format (PDF with an International Standard Serial Number (ISSN or an International Standard Book Number (ISBN will constitute effective publication, and the requirement for a Latin description or diagnosis for names of new taxa will be changed to a requirement for a description or diagnosis in either Latin or English. In addition, effective from 1 January 2013, new names of organisms treated as fungi must, in order to be validly published, include in the protologue (everything associated with a name at its valid publication the citation of an identifier issued by a recognized repository (such as MycoBank. Draft text of the new articles dealing with electronic publication is provided and best practice is outlined.To encourage dissemination of the changes made to the International Code of Nomenclature for algae, fungi, and plants, this article will be published in BMC Evolutionary Biology, Botanical Journal of the Linnean Society, Brittonia, Cladistics, MycoKeys, Mycotaxon, New Phytologist, North American Fungi, Novon, Opuscula Philolichenum, PhytoKeys, Phytoneuron, Phytotaxa, Plant Diversity and Resources, Systematic Botany and Taxon.

  8. Capacités exécutives pour la planification de séquences d'actions motrices réalisées sous contraintes spatiales et temporelles : une tâche de tapping visuo-spatial

    OpenAIRE

    Dione, Mariama

    2013-01-01

    In a constant changing environment, executive abilities allow us to organize sensory information of multiple sources and to adapt to diverse stuations while at the same time inhibiting inappropriate behaviors. research on the executive functions (EFS) have historical roots on neuropsychology, with the description of frontal patients that were showing disruptions in organizing their daily behaviors independently of any impairment in memory, language or general intelligence. A wide range of neu...

  9. Mainland Ali Mountain actively explore new ways to build a beautiful countryside---Taking Yongfu town Zhangping city of Fujian Province as an example%“大陆阿里山”积极探索美丽乡村建设的新路子--以福建省漳平市永福镇为例

    Institute of Scientific and Technical Information of China (English)

    温晓明

    2016-01-01

    Yongfu, Zhangping City, Fujian Province town of the trend of reform and opening up, relying on abundant natural and human resources advantage, the rural environmental protection and improvement, the development of green industry, pay attention to cultural heritage and innovation management as promoting effective starting point for the construction of the beautiful countryside, and actively build excellent industrial, ecological beauty, flexible mechanism, rich people, the beautiful rural construction pattern is of“beautiful en-vironment, life is sweet, successful exploration of social and beauty”, in fact, practical experience are creative, reflect the characteristics of the system, reflect the regularity, with demonstration.%福建省漳平市永福镇得改革开放风气之先,凭着得天独厚的自然、人文资源优势,把乡村环境保护与整治、发展绿色产业、注重文化传承、创新管理作为推进美丽乡村建设的有效抓手,积极构建“产业优、生态美、机制活、百姓富”美丽乡村建设格局,是对“环境优美、生活甜美、社会和美”的成功探索,其实践经验富有创造性、体现系统性,反映规律性,具有示范性。

  10. WORD BORROWING AND VOCABULARY EXCHANGE IN TURKISH DIALECTS: CASE OF OSMANIYE TATAR DIALECT / TÜRK LEHÇELERI ARASINDA SÖZCÜK ALIS VERISI VE SÖZ VARLIĞI DEĞISIMI: OSMANIYE TATAR AĞZI ÖRNEĞI

    Directory of Open Access Journals (Sweden)

    Dr. Ercan ALKAYA

    2008-08-01

    Full Text Available The basic vocabulary which constructs the main vocabulary of alanguage is the word that is transferred from generation to generation in everylanguage, has importance of first degree and reflects important concepts aboutmankind and his environment. The words dealing with body, color, andconcepts about nature, animal names, numbers, and the most used verbs,words of holy concepts and persons and traditions consist of basic vocabularyof a language. In this study, the change in vocabulary of Kazan Tatar Turks, whomigrated from Kazan, Orenburg and Samara regions and inhabited in thevillage of Osmaniye of Çifteler, Eskisehir after 1884, was investigated. Thedialects of Tatar Turks who migrated from Kazan and its surrounding areawere affected by the local people who have been living in that region. Thoughthey still protect phonetical and morphological features of their language, itwas affected by the local dialect and Turkey Turkish.The main changes in the vocabulary of Tatar Turks in Osmaniye villagewere evaluated under several headings.

  11. Conciliation of Hassan bin Ali bin Abi Talib and the end of strife صُّلْحُ الحسن بن علي بن أبي طالب ونهاية الفتنة

    OpenAIRE

    Mohamed Derradj

    2011-01-01

    يعتبر صلح الحسن بن علي بن أبي طالب "رضي الله عنه"، وتنازله عن الخلافة لمعاوية بن أبي سفيان منعطفًا تاريخيًا هامًا انتقلت به رئاسة الدولة الإسلامية من طور الخلافة الراشدة إلى طور الملكية السياسية. ولئن كان الكثير من الباحثين يرى في أحداث الفتنة الكبرى- وما نتج عنها من آثار سياسية بالغة التأثير على مستقبل الإسلام السياسي- انعطافًا كبيرًا عن خط الإسلام الأصيل، إلا أن ثمة مَن يرى أنها ليست كذلك، بل كانت تعبيرًا عنيفًا عن تحولات عميقة جدت في تكوين بنية المجتمع الإسلامي الذي بدأ ينتقل إلى عهد جديد ...

  12. Scale Effects in Laboratory and Pilot-Plant Reactors for Trickle-Flow Processes Les conséquences de l'extrapolation appliquée aux procédés à écoulement ruisselant réalisés en laboratoire et dans les réacteurs des unités-pilotes

    Directory of Open Access Journals (Sweden)

    Sie S. T.

    2006-11-01

    Full Text Available Research and development studies in a laboratory are necessarily conducted on a scale which is orders of magnitude smaller than that in commercial practice. In the case of the development and commercialization of an unprecedented novel process technology, available laboratory results have to be translated into envisaged technology on a commercial scale, i. e. the problem is that of scaling-up. However, in many circumstances the commercial technology is more or less defined as far as type of reactor is concerned and laboratory studies are concerned with the generation of predictive information on the behaviour of new catalysts, alternative feedstocks, etc. , in such a reactor. In many cases the complexity of feed composition and reaction kinetics preclude the prediction to be made on the basis of a combination of fundamental kinetic data and computer models, so that there is no other option than to simulate the commercial reactor on a laboratory scale, i. e. the problem is that of scaling-down. From the point of view of R & D Defficiency, the scale of the laboratory experiments should be as small as possible without detracting from the meaningfulness of the results. In the present paper some problems in the scaling-down of a trickle-flow reactor as applied in hydrotreating processes to kinetically equivalent laboratory reactors of different sizes will be discussed. Two main aspects relating to inequalities in fluid dynamics resulting from the differences in scale will be treated in more detail, viz. deviations from ideal plug flow and non ideal wetting or irrigation of the catalyst particles. Although a laboratory reactor can never be a true small-scale replica of a commercial trickle-flow reactor in all respects, it can nevertheless be made to provide representative data as far as the catalytic conversion aspects are concerned. By ressorting to measures such as catalyst bed dilution with fine catalytically inert material it proves possible to carry out meaningful process research on hydrotreating processes on the scale of micro-reactors. Les études et mises au point effectuées en laboratoire sont nécessairement effectuées à plus petite échelle que les réalisations commerciales. Dans le cas de la mise au point et de la commercialisation de la technologie d'un procédé nouveau, il faudra traduire les résultats obtenus en laboratoire pour la technologie envisagée à l'échelle commerciale; le problème est donc l'extrapolation vers le haut. Cependant, bien souvent, la technologie commerciale, pour ce qui touche au type de réacteur, est plus ou moins bien définie et les études de laboratoire s'attachent à produire des données permettant de prévoir le comportement qu'auront dans ce réacteur des catalyseurs nouveaux, de matières premières de substitution, etc. Dans bien des cas, étant donné la complexité de la composition de la matière première et la cinétique de réaction, il est impossible de mener la prévision en s'appuyant sur les données cinétiques et les modèles informatiques, de sorte qu'il n'y a pas d'autre solution que la simulation du réacteur commercial à l'échelle du laboratoire; le problème est donc l'extrapolation vers le bas. Du point de vue de l'efficacité des études de recherche et développement, pour les expériences en laboratoire, l'échelle devra être aussi petite que possible sans nuire à la signification des résultats. Le présent article examine certains problèmes liés à l'extrapolation vers le bas d'un réacteur à écoulement ruisselant telle qu'elle est appliquée dans les procédés d'hydrotraitement à des réacteurs de laboratoire de tailles différentes cinétiquement équivalents. Deux aspects principaux relatifs à des inégalités de dynamique des fluides résultant de différences d'échelle sont décrits plus en détail, i. e. les écarts par rapport à un écoulement idéal donnant lieu à un effet bouchon et au mouillage ou à l'irrigation non-idéal des particules de catalyseur. Bien qu'un réacteur de laboratoire ne puisse jamais être la réplique exacte à petite échelle d'un réacteur commercial à écoulement ruisselant, il peut néanmoins être conçu de façon à fournir des données représentatives en ce qui concerne les aspects de la conversion catalytique. En considérant les mesures telles que la dilution du lit de catalyseur à l'aide d'un produit inerte du point de vue catalytique, il se révèle possible de mener à bien une recherche significative sur les procédés d'hydrotraitement à l'échelle des micro-réacteurs.

  13. Analyse Conseptuelle Et Perceptice Du Traitement Littéraire De L’aliénatiın Dans “La Nausée “ De Jean Paul Sartre Analysis Of Conceptual And Perceptual Processing Of Literary Of Alienation In Nausea By Jean-Paul Sartre

    Directory of Open Access Journals (Sweden)

    Muzaffer KAYA

    2013-03-01

    Full Text Available In this work where a phlosophical thought is told and explained,Jean Paul Sartre states his phlosophic views by means of protagonistRoquentin. Roquentin lives in a world that is not understood by himand he, bevilderedly, observes how the urban bourgeoisie cant perceivethe reflections of the reality.Taking care of his thoughts to be clear, Jean Paul Sartre used aplain tongue and paid attention to his style to be cognisable. This is the general characteristic of that period.Authors made a point of beingapparent intellectually in literary languageThe basic idea of the novel is that the hero of the work Roquentinis in a constant anxiety and demoralization. This is such a state ofdistress that led our hero to analyze the situation and try to understandthe process. He decides to define this anxiety,he felt, as nausea andrealizes that he does not recognize the status of this nausea.Accordingto him nausea is being revolted at everything and and a state ofalienation.Increasing state of nausea,in time, is an alienation from theobjects, the society,self-precense,women and finally the world.In this study we examined the sense of alienation in Jean PaulSartre’s Nausea under four sub-headings. Examining the personality ofthe Protagonist Rocquentin we probed that how he alienated from theobjects, the society, himself and the women and we came to aconclusion. In this context,we stated that alienation is one of the mostimportant social problems of our time and these problems causepsychic deterioration that arise through the confliction of the oldculturel values and the new habitudes. Cette oeuvre est un récit dans lequel se développe toute uneréflexion philosophique où Sartre montre son refus envers la société engénéral par le biais de Roquetin, qui vit dans un monde où il ne trouveaucun sens à la vie et où il s’étonne de voir que la bourgeoisie de la villene voit pas les aspects de la réalité qui, pour lui, sont assez évidents.Pour exprimer ses idées, Sartre utilise un langage sans ornementsrhétoriques qui peuvent rendre difficile sa compréhension, puisquesurtout, les auteurs engagés du XXème siècle (comme Sartre donnentplus d’importance au message qu’à la forme dans l’objectif d’être lu parle plus possible public.Le thème principal de l’oeuvre est le fait que Roquentin se trouvedans un état d’angoisse, un état de démoralisation ; une sorte d’ennuiqui va le mener à essayer de réfléchir sur ce qu’est l’existence ettrouver un moyen de l’expliquer. Il ressent une sorte d’angoisse qu’il vaappeler la nausée et il se rend compte qu’il ne peut définir l’existence decette nausée. Pour lui ce sentiment de nausée est comme une sorted’étrangeté et de dégout envers tout. Cette nausée qui progresse avec letemps se fait sentir en premier devant les objets puis devant personnesrencontrées et s’étend à tout son rapport au monde.

  14. Zakharia Katia et Cheiban Ali (dir., Savoirs et Pouvoirs : genèse des traditions, traditions réinventées, coordonnée par, Maisonneuve et Larose, Maison de l’Orient et de la Méditerranée, 2008, 275 p.

    Directory of Open Access Journals (Sweden)

    Thomas Brisson

    2009-05-01

    Full Text Available Issues d’un séminaire organisé au GREMMO (Groupe de recherches et d’études sur la Méditerranée et le Moyen-Orient, les onze contributions rassemblées par K. Zahharia et A. Cheiban font dialoguer des chercheurs issus de disciplines différentes (historiens, sociologues, politologues, anthropologues, etc. autour d’un thème aussi riche que complexe : celui de la liaison entre savoirs et pouvoirs. L’intérêt de cette étude, ce qui en constitue parfois aussi les limites, tient en grande partie dan...

  15. Çokanlamlilik Ve Değiştirim Üzerine Anlambilimsel Bir Çalişma: Fransizcada Algilama Eylemleri Une Etude Sémantique Sur La Polysémie Et La Commutation : Le Cas Des Verbes De Perception En Français

    Directory of Open Access Journals (Sweden)

    Fulya BOYRAZ

    2013-09-01

    Full Text Available Dans ce travail, nous avons distingué l’expression linguistique dela perception d’une phénoménologie de la perception et nous n’avonsétudié que les “verbes de perception”. Il faut noter justement ici que lesverbes dont le contenu sémantique désigne le perceptible (comme puer,luire… sont très différents des verbes qui imposent l’achèvement de laperception (voir, entendre… et des verbes dont la signification impliqueune intention précise (regarder, toucher, écouter…. Dans ce cadre, cespremiers sont écartés de cette étude. Cet article vise à aborder lesproblèmes engendrés par la polysémie et la commutation. Nous avonssuivi une démarche sémantique et discursive en vue d’observer lesacceptions de ces verbes et d’exposer les sous-catégories en tenantcompte de la richesse d’expression que fournissent ces verbes.Il est possible de définir la commutation comme fait desubstitutiond’un mot par un autre lorsqu’ils sont polysémiques ou lorsqu’ilsrenvoient à la même zone de signification. Bien que les verbes deperception en français soient polysémiques, il n’est pas difficile derelever le sens discursif en tenant compte du contexte et lacommutation peut se faire selon les possibilités du contexte. Toutefois,il y a des cas où ces verbes sont employés pour désigner plutôt lerésultat d’une activité intellectuelle et ils recouvrent dans ce cadre, lasignification du verbe “comprendre”. Le fait qui ne permet pas tojoursune commutation entre ces verbes et qui pose certains problèmesdidactiques, surtout pour expliquer le sens linguistique et la valeurdiscursive dans l’enseignement du français langue étrangère. Bu çalışmada, algılamanın dilsel ifadesi olan sözcükler, bir olgu olan “algı”dan ayrılmış ve sadece sözcük türü olarak “algılama eylemleri” araştırma konusu yapılmıştır. Anlamsal içeriği, kokmak, parıldamak, çatırdamak gibi algılananın algıya neden olan özelliklerini ifade eden eylemlerin, algılama eyleminin gerçekleşimini ifade eden eylemlerden (görmek, duymak gibi ve algılamaya yöneltilen bilinçli eylemlerden (bakmak, dinlemek, dokunmak gibi ayrı tutulması gerekir. Bu çalışmada, yukarıda sözü edilen eylemlerden ilk grubu oluşturanlar inceleme dışında tutulmuş ve algıya yönelik bilinçli ve istemli algı ifade den eylemlerle, bu eylemlerin bir sonucu olarak ortya çıkan algılama ya da algılayamama durumunu ifade eden eylemler söz konusu edilmiştir. Çalışmamızda Fransızca’daki algılama eylemleri, özellikle çokanlamlı yapıları nedeniyle ortaya koydukları sorunlar çerçevesinde anlambilimsel açıdan ve söylemsel boyuttaki ifade zenginlikleri nedeniyle söylemsel açıdan ele alınmıştır.Değiştirim anlamdaş ya da yakın anlamlı sözcükler arasında birbirinin yerine geçme durumu olarak tanımlanabilir ve değiştirim yapılabilmesi için sözcede (énoncé ya da tümcede (phrase anlamsal ve söylemsel değerin korunması ön koşuldur. Fransızcanın algılama eylemleri (toucher, regarder, voir, écouter, entendre, sentir çokanlamlı yapıya sahip olmalarına rağmen söylem içerisinde ve bağlam değerlendirildiğinde anlamları kesinleşmekte ve değişitirim (commutation söz konusu bağlamın izin verdiği ölçüde, gerçekleşebilmektedir. Oysa ki bu sözcükler duyusal algı değil de zihinsel algı sürecinin sonucu olan “anlamak” sözcüğünün yerine geçtikleri zaman dilsel ve söylemsel sorunlar ortaya çıkmakta, değişitirim seçenekleri daralmakta ve özellikle Fransızcanın yabancı dil olarak öğretiminde söylemsel değeri açıklamak daha zor hale gelmektedir.

  16. Family 13 carbohydrate-binding module of alginate lyase from Agarivorans sp. L11 enhances its catalytic efficiency and thermostability, and alters its substrate preference and product distribution.

    Science.gov (United States)

    Li, Shangyong; Yang, Xuemei; Bao, Mengmeng; Wu, Ying; Yu, Wengong; Han, Feng

    2015-05-01

    The carbohydrate-binding module (CBM) in polysaccharide hydrolases plays a key role in the hydrolysis of cellulose, xylan and chitin. However, the function of CBM in alginate lyases has not been elucidated. A new alginate lyase gene, alyL2, was cloned from the marine bacterium Agarivorans sp. L11 by using degenerate and site-finding PCR. The alginate lyase, AlyL2, contained an N-terminal CBM13 and a C-terminal catalytic family 7 polysaccharide lyase (PL7) module. To better understand the function of CBM13 in alginate lyase AlyL2, the full-length enzyme (AlyL2-FL) and its catalytic module (AlyL2-CM) were expressed in Escherichia coli and characterized. The specific activity and catalytic efficiency of AlyL2-FL were approximately twice those of AlyL2-CM. The half-lives of AlyL2-FL were 4.7-6.6 times those of AlyL2-CM at 30-50°C. In addition, the presence of CBM13 in AlyL2 changed its substrate preference and increased the percentage of disaccharides from 50.5% to 64.6% in the total products. This first report of the function of CBM13 in alginate lyase provides new insights into the degradation of alginate by marine microorganisms.

  17. Neurological outcome after experimental lung injury.

    Science.gov (United States)

    Bickenbach, Johannes; Biener, Ingeborg; Czaplik, Michael; Nolte, Kay; Dembinski, Rolf; Marx, Gernot; Rossaint, Rolf; Fries, Michael

    2011-12-15

    We examined the influences of acute lung injury and hypoxia on neurological outcome. Functional performance was assessed using a neurocognitive test and a neurologic deficit score (NDS) five days before. On experimental day, mechanically ventilated pigs were randomized to hypoxia only (HO group, n=5) or to acute lung injury (ALI group, n=5). Hemodynamics, respiratory mechanics, systemic cytokines and further physiologic variables were obtained at baseline, at the time of ALI, 2, 4 and 8h thereafter. Subsequently, injured lungs were recruited and animals weaned from the ventilator. Neurocognitive testing was re-examined for five days. Then, brains were harvested for neurohistopathology. After the experiment, neurocognitive performance was significantly worsened and the NDS increased in the ALI group. Histopathology revealed no significant differences. Oxygenation was comparable between groups although significantly higher inspiratory pressures occured after ALI. Cytokines showed a trend towards higher levels after ALI. Neurocognitive compromise after ALI seems due to a more pronounced inflammatory response and complex mechanical ventilation.

  18. Alcoholic liver injury:Influence of gender and hormones

    Institute of Scientific and Technical Information of China (English)

    Patricia; K; Eagon

    2010-01-01

    This article discusses several subjects pertinent to a consideration of the role of gender and hormones in alcoholic liver injury (ALI). Beginning with an overview of factors involved in the pathogenesis of ALI, we review changes in sex hormone metabolism resulting from alcohol ingestion, summarize research that points to estrogen as a cofactor in ALI, consider evidence that gut injury is linked to liver injury in the setting of alcohol, and briefly review the limited evidence regarding sex hormones and gut...

  19. Characterization of a New Cold-Adapted and Salt-Activated Polysaccharide Lyase Family 7 Alginate Lyase from Pseudoalteromonas sp. SM0524

    Science.gov (United States)

    Chen, Xiu-Lan; Dong, Sheng; Xu, Fei; Dong, Fang; Li, Ping-Yi; Zhang, Xi-Ying; Zhou, Bai-Cheng; Zhang, Yu-Zhong; Xie, Bin-Bin

    2016-01-01

    Marine bacterial alginate lyases play a role in marine alginate degradation and carbon cycling. Although a large number of alginate lyases have been characterized, reports on alginate lyases with special characteristics are still rather less. Here, a gene alyPM encoding an alginate lyase of polysaccharide lyase family 7 (PL7) was cloned from marine Pseudoalteromonas sp. SM0524 and expressed in Escherichia coli. AlyPM shows 41% sequence identity to characterized alginate lyases, indicating that AlyPM is a new PL7 enzyme. The optimal pH for AlyPM activity was 8.5. AlyPM showed the highest activity at 30°C and remained 19% of the highest activity at 5°C. AlyPM was unstable at temperatures above 30°C and had a low Tm of 37°C. These data indicate that AlyPM is a cold-adapted enzyme. Moreover, AlyPM is a salt-activated enzyme. AlyPM activity in 0.5–1.2 M NaCl was sixfolds higher than that in 0 M NaCl, probably caused by a significant increase in substrate affinity, because the Km of AlyPM in 0.5 M NaCl decreased more than 20-folds than that in 0 M NaCl. AlyPM preferably degraded polymannuronate and mainly released dimers and trimers. These data indicate that AlyPM is a new PL7 endo-alginate lyase with special characteristics. PMID:27486451

  20. Acute lung injury and ARDS in acute pancreatitis: Mechanisms and potential intervention

    Institute of Scientific and Technical Information of China (English)

    Roland; Andersson

    2010-01-01

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem,with a mortality rate in the range of 30%-40%.The present review evaluates underlying pathophysiological mechanisms in both ALI and ARDS and potential clinical implications.Several mediators and pathophysiological pathways are involved during the different phases of ALI and ARDS.The initial exudative phase is characterized by diffuse alveolar damage,microvascular injury and inf...

  1. Endovascular Management of Acute Limb Ischemia.

    LENUS (Irish Health Repository)

    Hynes, Brian G

    2011-09-14

    Despite major advances in pharmacologic and endovascular therapies, acute limb ischemia (ALI) continues to result in significant morbidity and mortality. The incidence of ALI may be as high as 13-17 cases per 100,000 people per year, with mortality rates approaching 18% in some series. This review will address the contemporary endovascular management of ALI encompassing pharmacologic and percutaneous interventional treatment strategies.

  2. Using the Agile Development Methodology and Applying Best Practice Project Management Processes

    Science.gov (United States)

    2014-12-01

    decisions made by the programming group will ever be architecturally significant (Abrahamsson, Ali Babar , and Kruchten 2010, 18). Agile factions...point at the analysis and documentation that accompanies it, stating it is generally “you ain’t gonna need it” (YAGNI) (Abrahamsson, Ali Babar , and...Abrahamsson, Pekka, Muhammad Ali Babar and Philippe Kruchten. 2010. “Agility and Architecture: Can They Coexist?” IEEE Software 27(2):16-22. Agile

  3. Developing an Evaluation Method for Middleware-Based Software Architectures of Airborne Mission Systems

    Science.gov (United States)

    2007-07-01

    documented using an architecture knowledge management tool also developed at NICTA. 31 DSTO-TR-2204 9. References [Ali- Babar & Gorton 2004] [Ali... Babar et al. 2005] [Allen et al. 2002] [Bachmann et al. 2003] [Barbacci et al. 1995] [Bass et al. 2003] [Basse/al. 2001] [Bengstsson et al. 2004...Boehm&In 1996] [CORBA 2006] [Clements et al. 2001] Ali- Babar , M. & Gorton, I. (2004) Comparison of Scenario-Based Software Architecture

  4. 1α,25-Dihydroxyvitamin D3 Ameliorates Seawater Aspiration-Induced Acute Lung Injury via NF-κB and RhoA/Rho Kinase Pathways

    OpenAIRE

    Minlong Zhang; Mingqing Dong; Wei Liu; Li Wang; Ying Luo; Zhichao Li; Faguang Jin

    2014-01-01

    INTRODUCTION: Inflammation and pulmonary edema are involved in the pathogenesis of seawater aspiration-induced acute lung injury (ALI). Although several studies have reported that 1α,25-Dihydroxyvitamin D3 (calcitriol) suppresses inflammation, it has not been confirmed to be effective in seawater aspiration-induced ALI. Thus, we investigated the effect of calcitriol on seawater aspiration-induced ALI and explored the probable mechanism. METHODS: Male SD rats receiving different doses of calci...

  5. JPRS Report, Near East & South Asia India

    Science.gov (United States)

    2007-11-02

    Indian partition on 14 August 1947. Mohammed Ali Jinnah , the father of Pakistan, had proposed an Islamic nation within India in the All India...taken less than three years to cause the total disintegration of Pakistan. People started to point fin- gers at Mohammed Ali Jinnah even when he was...which even the Mogul emperors have praised, and which has been the capital of many kingdoms. However, Pakistan’s creator, Mohammed Ali Jinnah , decided

  6. JPRS Report, Near East and South Asia.

    Science.gov (United States)

    2007-11-02

    country stand at the time of partition . He was of the opinion that the ruling party is angry and revengeful because the Mohajirs withdrew their...Ali Jinnah and under his dynamic leadership Pakistan was created. Every Muslim was ambitious to be blessed with a country where they should be free...open for the Muslims coming to the territory declared ’Pakistan.’ Quaid-i-Azam Muhammad Ali Jinnah flanked with his trusted workers like Liaqat Ali

  7. Pakistan’s Domestic Political Developments

    Science.gov (United States)

    2005-09-19

    Nation) Muhammed Ali Jinnah and his lieutenant, Liaquat Ali Khan, the PML was weakened upon their premature deaths in 1948 and 1951 ( Jinnah by natural...two parliamentary seats in the 1993 and 1997 elections). Notable Leaders of Pakistan Governor-General Mohammed Ali Jinnah 1947-1948 Prime Minister...service. 44 The Muttahida Quami Movement (MQM) is a Sindhi regional party mainly composed of the descendants of pre- partition immigrants (Muhajirs) from

  8. Potencialni antitumorski učinki ekstraktov Marama fižola (Tylosema esculentum)

    OpenAIRE

    Topolovec, Maja

    2010-01-01

    Rak debelega črevesja (kolona) in danke (rektum), ki mu pravimo tudi kolorektalni rak, spada med najpogostejše oblike raka v razvitem svetu. Zato smo v diplomskem delu želeli ugotovit, ali lahko s pomočjo rastlinskih ekstraktov pripomoremo k preventivnemu ali dopolnilnemu zdravstvenemu učinku. Namen naše raziskave je bil raziskati ali imata Marama fižol in gomolj pozitiven učinek na zaviranje rasti ali citotoksičnost celic raka debelega črevesa. Uporabili smo ekstrakte Marama fižola in gomolj...

  9. Surfactant for pediatric acute lung injury.

    Science.gov (United States)

    Willson, Douglas F; Chess, Patricia R; Notter, Robert H

    2008-06-01

    This article reviews exogenous surfactant therapy and its use in mitigating acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) in infants, children, and adults. Biophysical and animal research documenting surfactant dysfunction in ALI/ARDS is described, and the scientific rationale for treatment with exogenous surfactant is discussed. Major emphasis is placed on reviewing clinical studies of surfactant therapy in pediatric and adult patients who have ALI/ARDS. Particular advantages from surfactant therapy in direct pulmonary forms of these syndromes are described. Also discussed are additional factors affecting the efficacy of exogenous surfactants in ALI/ARDS.

  10. 78 FR 66713 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-06

    ..., Baldwin, NY 11510. Officer: Kamran Ali, President (QI), Application Type: New NVO & OFF License. Miragrown... 2D, Philadelphia, PA 19115. Officers: Mykola Chobotar, Chief Executive Manager (QI), James...

  11. 高密度电阻率法探测地下人防巷道装置类型选择与异常识别%unit type ChoSen for hiGh denSity reSiStivity method uSed in deteCtion of underGround Civil Air defenSe workS And reCoGnition of AnomAly

    Institute of Scientific and Technical Information of China (English)

    郭厚军; 张国鸿

    2015-01-01

    Based on Wenner arrangement and tri-pole unit test over known underground civil air defense works, and analysis of anomalous features, this paper introduced the use of right unit type of high density resistivity method that tells difference in resistivity of underground media and how to recognize the anomalous marker correctly.%通过在已知在已揭露的地下人防巷道上方高密度电阻率法中温纳装置、三极装置的试验以及异常特征分析,说明利用地下介质的电阻率差异,采用高密度电阻率法探测地下人防巷道工作时,应选择好装置类型,且要正确地识别其异常标志。

  12. 22q11 deletion syndrome and urogenital manifestationsA clinicopathological case report and review of the literatureM.Vachette MD*, GE.Grant MD*, J.Bouquet de Joliniere MD.PhD*, M. Jotterand MD** N.Ben Ali MD*, A.Feki MD.PhD * and R.Brugger MD.*Department of gynecology and obstetrics, HFR, Fribourg, Switzerland.** Institute of pathology, CHUV, Lausanne, Switzerland.

    Directory of Open Access Journals (Sweden)

    Jean Bouquet De Jolinière

    2016-11-01

    Full Text Available Background: Deletion in the chromosomal region 22q11 results from the abnormal development of the third and fourth pharyngeal pouches during embryonic life and presents an expansive phenotype with more than 180 clinical features described that involve every organ and system. History and Signs: A 23-year-old African woman presented for the first trimester echography, which revealed an isolated anechoic structure suggesting a ureteral dilatation. The suspicion of a malposition of great arteries in the second trimester indicated an amniocentesis leading to a diagnosis of 22q11 deletion. Outcome: At 32 weeks, the patient was admitted for premature rupture of membranes and gave birth 2 weeks later to a male newborn that presented a respiratory distress syndrome and probably died secondary to a tracheal stenosis. Necropsy revealed typical clinical features of 22q11 deletion associated with left renal agenesis, hypospadias and penile hypoplasia. Conclusions: We report a case of 22q11 deletion syndrome with typical clinical features associated with urogenital manifestations suspected at the first trimester ultrasound.

  13. Needle Acupuncture for Substance Use Disorders: A Systematic Review

    Science.gov (United States)

    2015-01-01

    European Journal of Integrative Medicine, Vol. 4, Suppl. 1, September 2012, p. 116. 105 Hasan, S. I., M. Mustafa, R. Abd Rashid , A. Mohd Ali, M. K...Neuropsychopharmacology, Vol. 15, Suppl. 3, 2005, p. S580. Mustafa, M., S. I. Hasan, R. Abd Rashid , A. Mohd Ali, M. K. Mohd Ishak, M. A. Said, and M. H. Habil

  14. Islamist Terrorist Networks in Bosnia and Herzegovina

    Science.gov (United States)

    2009-09-01

    20Embargo.htm (accessed April 10, 2009). 27 Rabia Ali and Lawrence Lifschultz, “Why Bosnia?” Third World Quarterly 15, no. 3 (September 1994), 369. http...Economic Growth. (June 1996). Ali, Rabia and Lawrence Lifschultz. “Why Bosnia?” Third World Quarterly 15, no. 3 (September 1994). http://www.jstor.org

  15. ALICE-ARC integration

    DEFF Research Database (Denmark)

    Anderlik, Csaba; Gregersen, Anders Rhod; Kleist, Josva;

    2008-01-01

    Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The interoperation has two aspects, one is the data...

  16. Association between insertion/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury/acute respiratory distress syndrome: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Matsuda Akihisa

    2012-08-01

    Full Text Available Abstract Background A previous meta-analysis reported a positive association between an insertion/deletion (I/D polymorphism in the angiotensin-converting enzyme gene (ACE and the risk of acute lung injury (ALI/acute respiratory distress syndrome (ARDS. Here, we updated this meta-analysis and additionally assessed the association of this polymorphism with ALI/ARDS mortality. Methods We searched electronic databases through October 2011 for the terms “angiotensin-converting enzyme gene”, “acute lung injury”, and “acute respiratory distress syndrome,” and reviewed all studies that reported the relationship of the I/D polymorphism in ACE with ALI/ARDS in humans. Seven studies met the inclusion criteria, comprising 532 ALI/ARDS patients, 3032 healthy controls, and 1432 patients without ALI/ARDS. We used three genetic models: the allele, dominant, and recessive models. Results The ACE I/D polymorphism was not associated with susceptibility to ALI/ARDS for any genetic model. However, the ACE I/D polymorphism was associated with the mortality risk of ALI/ARDS in Asian subjects ( Pallele Pdominant = 0.001, Precessive = 0.002. This finding remained significant after correction for multiple comparisons. Conclusions There is a possible association between the ACE I/D polymorphism genotype and the mortality risk of ALI/ARDS in Asians.

  17. EO-1 Advanced Land Imager Modulation Transfer Functions

    Science.gov (United States)

    2000-03-22

    has used a laser unequal-path interferometer ( LUPI ) to characterize the WFE of the ALI. They obtained interferograms at a dozen points distributed...MATED ZERNIKE POLYNOMIAL COEFFICIENTS OF WAVEFRONT ERRORS SSG, Inc. used a laser unequal-path interferometer ( LUPI ) to characterize the WFE of the ALI

  18. 77 FR 74126 - Airworthiness Directives; Bombardier, Inc. Airplanes

    Science.gov (United States)

    2012-12-13

    ... Maintenance Requirements Manual, PSM 1-84-7. The actions described in this service information are intended to... Limitations Items (ALI) Part 2, Bombardier Q400 Dash 8 Maintenance Requirements Manual, PSM 1-84-7. The... Items (ALI) Part 2, Bombardier Q400 Dash 8 Maintenance Requirements Manual, PSM 1-84-7. When this TR...

  19. Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastography

    NARCIS (Netherlands)

    Stravitz, R. Todd; Lisman, Ton; Luketic, Velimir A.; Sterling, Richard K.; Puri, Puneet; Fuchs, Michael; Ibrahim, Ashraf; Lee, William M.; Sanyal, Arun J.

    2012-01-01

    Background & Aims: Patients with acute liver injury/failure (ALI/ALF) are assumed to have a bleeding diathesis on the basis of elevated INR; however, clinically significant bleeding is rare. We hypothesized that patients with ALI/ALF have normal hemostasis despite elevated INR. Methods: Fifty-one pa

  20. Alveolar epithelial cells (A549) exposed at the air-liquid interface to diesel exhaust: First study in TNO's powertrain test center

    NARCIS (Netherlands)

    Kooter, I.M.; Alblas, M.J.; Jedynska, A.D.; Steenhof, M.; Houtzager, M.M.G.; Ras, M.G. van

    2013-01-01

    Air–liquid interface (ALI) exposures enable in vitro testing ofmixtures of gases and particles such as diesel exhaust (DE). The main objective of this study was to investigate the feasibility of exposing human lung epithelial cells at the ALI to complete DE generated by a heavy-duty truck in the sta

  1. High-Speed Large-Alphabet Quantum Key Distribution Using Photonic Integrated Circuits

    Science.gov (United States)

    2014-01-28

    Lett., 93:010503, Jul 2004. [14] Irfan Ali-Khan, Curtis J. Broadbent , and John C. Howell. Large-Alphabet Quantum Key Distribution Using Energy-Time...Rev. Lett., 92:167903, Apr 2004. [20] Irfan Ali-Khan, Curtis J. Broadbent , and John C. Howell. Large-Alphabet Quantum Key Distribution Using Energy

  2. The plant P4-ATPase ALA2 is involved in flipping of phosphatidylserine analogues

    DEFF Research Database (Denmark)

    Lopez Marques, Rosa Laura

    by lack of DRS2 in yeast. Tissue specific expression patterns of ALA2 and ALIS genes indicate that different ALIS isoforms may interact with ALA2 in diverse parts of the plant. At present we are studying the subcellular localization of ALA2 in planta in order to understand better its possible...

  3. The plant P4-ATPase ALA2 is involved in flipping of phosphatidylserine analogues

    DEFF Research Database (Denmark)

    Poulsen, Lisbeth Rosager

    by lack of DRS2 in yeast. Tissue specific expression patterns of ALA2 and ALIS genes indicate that different ALIS isoforms may interact with ALA2 in diverse parts of the plant. At present we are studying the subcellular localization of ALA2 in planta in order to understand better its possible...

  4. Evaluation of air-liquid interface exposure systems for in vitro assessment of airborne pollutants

    Science.gov (United States)

    Exposure of cells to airborne pollutants at the air-liquid interface (ALI) is a more realistic approach than exposures of submerged cells. The published literature, however, describes irreproducible and/or unrealistic experimental conditions using ALI systems. We have compared fi...

  5. Critical Evaluation of Air-Liquid Interface Exposure Devices for In Vitro Assessment of Atmospheric Pollutants

    Science.gov (United States)

    Exposure of cells to atmospheric pollutants at the air-liquid interface (ALI) is a more realistic approach than exposures of attached cells submerged in liquid medium. However, there is still limited understanding of the ideal ALI device design features that permit reproducible a...

  6. The risk of acute liver injury among users of antibiotic medications in the protect project: The results of a nested case-control study using european outpatient healthcare data

    NARCIS (Netherlands)

    Brauer, Ruth; Douglas, Ian; Rodriguez, Luis Alberto Garcia; Bate, Andrew; Smeeth, Liam; Reynolds, Robert; Klungel, Olaf; Ruigomez, Ana

    2014-01-01

    Background: The estimated incidence of antibiotic induced acute liver injury (ALI) varies widely, depending on the case definition and source population used. Objectives: We aimed to compare the risk of ALI associated with exposure to any type of antibiotic in a Spanish and United Kingdom (UK) datab

  7. Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy.

    Directory of Open Access Journals (Sweden)

    Masashi Aizawa

    Full Text Available Previous clinical and experimental studies have indicated that cells responsible for IgA nephropathy (IgAN, at least in part, are localized in bone marrow (BM. Indeed, we have demonstrated that murine IgAN can be experimentally reconstituted by bone marrow transplantation (BMT from IgAN prone mice in not only normal mice, but also in alymphoplasia mice (aly/aly independent of IgA+ cells homing to mucosa or secondary lymphoid tissues. The objective of the present study was to further assess whether secondary lymph nodes (LN contribute to the progression of this disease. BM cells from the several lines of IgAN prone mice were transplanted into aly/aly and wild-type mice (B6. Although the transplanted aly/aly showed the same degree of mesangial IgA and IgG deposition and the same serum elevation levels of IgA and IgA-IgG immune-complexes (IC as B6, even in extent, the progression of glomerular injury was observed only in B6. This uncoupling in aly/aly was associated with a lack of CD4+ T cells and macrophage infiltration, although phlogogenic capacity to nephritogenic IC of renal resident cells was identical between both recipients. It is suggested that secondary LN may be required for the full progression of IgAN after nephritogenic IgA and IgA/IgG IC deposition.

  8. Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection

    NARCIS (Netherlands)

    R.A. Bem; J.B.M. van Woensel; A.P. Bos; A. Koski; A.W. Farnand; J.B. Domachowske; H.F. Rosenberg; T.R. Martin; G. Matute-Bello

    2009-01-01

    Severe infection with respiratory syncytial virus (RSV) in children can progress to respiratory distress and acute lung injury (ALI). Accumulating evidence suggests that mechanical ventilation (MV) is an important cofactor in the development of ALI by modulating the host immune responses to bacteria

  9. Air–liquid interface enhances oxidative phosphorylation in intestinal epithelial cell line IPEC-J2

    Science.gov (United States)

    Klasvogt, Sonja; Zuschratter, Werner; Schmidt, Anke; Kröber, Andrea; Vorwerk, Sandra; Wolter, Romina; Isermann, Berend; Wimmers, Klaus; Rothkötter, Hermann-Josef; Nossol, Constanze

    2017-01-01

    The intestinal porcine epithelial cell line IPEC-J2, cultured under the air–liquid interface (ALI) conditions, develops remarkable morphological characteristics close to intestinal epithelial cells in vivo. Improved oxygen availability has been hypothesised to be the leading cause of this morphological differentiation. We assessed oxygen availability in ALI cultures and examined the influence of this cell culture method on glycolysis and oxidative phosphorylation in IPEC-J2 using the submerged membrane culture (SMC) and ALI cultures. Furthermore, the role of HIF-1 as mediator of oxygen availability was analysed. Measurements of oxygen tension confirmed increased oxygen availability at the medium–cell interface and demonstrated reduced oxygen extraction at the basal compartment in ALI. Microarray analysis to determine changes in the genetic profile of IPEC-J2 in ALI identified 2751 modified transcripts. Further examinations of candidate genes revealed reduced levels of glycolytic enzymes hexokinase II and GAPDH, as well as lactate transporting monocarboxylate transporter 1 in ALI, whereas expression of the glucose transporter GLUT1 remained unchanged. Cytochrome c oxidase (COX) subunit 5B protein analysis was increased in ALI, although mRNA level remained at constant level. COX activity was assessed using photometric quantification and a three-fold increase was found in ALI. Quantification of glucose and lactate concentrations in cell culture medium revealed significantly reduced glucose levels and decreased lactate production in ALI. In order to evaluate energy metabolism, we measured cellular adenosine triphosphate (ATP) aggregation in homogenised cell suspensions showing similar levels. However, application of the uncoupling agent FCCP reduced ATP levels in ALI but not in SMC. In addition, HIF showed reduced mRNA levels in ALI. Furthermore, HIF-1α protein was reduced in the nuclear compartment of ALI when compared to SCM as confirmed by confocal microscopy

  10. Biomarkers in acute lung injury.

    Science.gov (United States)

    Mokra, Daniela; Kosutova, Petra

    2015-04-01

    Acute respiratory distress syndrome (ARDS) and its milder form acute lung injury (ALI) may result from various diseases and situations including sepsis, pneumonia, trauma, acute pancreatitis, aspiration of gastric contents, near-drowning etc. ALI/ARDS is characterized by diffuse alveolar injury, lung edema formation, neutrophil-derived inflammation, and surfactant dysfunction. Clinically, ALI/ARDS is manifested by decreased lung compliance, severe hypoxemia, and bilateral pulmonary infiltrates. Severity and further characteristics of ALI/ARDS may be detected by biomarkers in the plasma and bronchoalveolar lavage fluid (or tracheal aspirate) of patients. Changed concentrations of individual markers may suggest injury or activation of the specific types of lung cells-epithelial or endothelial cells, neutrophils, macrophages, etc.), and thereby help in diagnostics and in evaluation of the patient's clinical status and the treatment efficacy. This chapter reviews various biomarkers of acute lung injury and evaluates their usefulness in diagnostics and prognostication of ALI/ARDS.

  11. The Sclerotic Scatter Limbal Arc Is More Easily Elicited under Mesopic Rather Than Photopic Conditions.

    Directory of Open Access Journals (Sweden)

    Eric Denion

    Full Text Available We aimed to determine the limbal lighting illuminance thresholds (LLITs required to trigger perception of sclerotic scatter at the opposite non-illuminated limbus (i.e. perception of a light limbal scleral arc under different levels of ambient lighting illuminance (ALI.Twenty healthy volunteers were enrolled. The iris shade (light or dark was graded by retrieving the median value of the pixels of a pre-determined zone of a gray-level iris photograph. Mean keratometry and central corneal pachymetry were recorded. Each subject was asked to lie down, and the ALI at eye level was set to mesopic values (10, 20, 40 lux, then photopic values (60, 80, 100, 150, 200 lux. For each ALI level, a light beam of gradually increasing illuminance was applied to the right temporal limbus until the LLIT was reached, i.e. the level required to produce the faint light arc that is characteristic of sclerotic scatter at the nasal limbus.After log-log transformation, a linear relationship between the logarithm of ALI and the logarithm of the LLIT was found (p<0.001, a 10% increase in ALI being associated with an average increase in the LLIT of 28.9%. Higher keratometry values were associated with higher LLIT values (p = 0.008 under low ALI levels, but the coefficient of the interaction was very small, representing a very limited effect. Iris shade and central corneal thickness values were not significantly associated with the LLIT. We also developed a censored linear model for ALI values ≤ 40 lux, showing a linear relationship between ALI and the LLIT, in which the LLIT value was 34.4 times greater than the ALI value.Sclerotic scatter is more easily elicited under mesopic conditions than under photopic conditions and requires the LLIT value to be much higher than the ALI value, i.e. it requires extreme contrast.

  12. Change and significance of plasma surfactant protein D level in patients with severe multiple trauma combined with acute lung injury%严重多发伤并发急性肺损伤患者血浆中肺表面活性物质相关蛋白D的变化及意义

    Institute of Scientific and Technical Information of China (English)

    王白云; 徐道妙

    2008-01-01

    Objective To dynamically measure level of surfactant protein D(SP-D)in patients with severe multiple trauma and discuss the relationship between SP-D and acute lung injury(ALI)/ARDS and its clinical significance. Methods A total of 36 patients with severe multiple trauma were divided into ALI/ARDS group(20 patients)and non-ALI/ARDS group(16 patients).Peripheral blood samples were collected at days 1,3,7 and 14 after trauma for calculating lung injury score(LIS)and PaO2/FiO2 ratio.Another 12 healthy persons were served as control group.Plasma SP-D levels were measured by using enzyme linked immunoabsorbent assay(ELISA). Results The plasma SP-D levels in ALI/ARDS group were markedly higher than those of control group and non-ALI/ARDS group(P<0.01).In ALI/ARDS group,the plasma SP-D levels in severe lung injury group were significantly higher than those of modcrate lung injury group(P<0.05).The plasma SP-D levels in ALI/ARDS group were inversely related to their PaO2/FiO2 ratios(rs=-0.745,P<0.01). Conclusions The plasma SP-D level is relevant not only to the occurrence of traumatic ALI/ARDS after multiple trauma,but also closely to the severity of lung injury,indicating that plasma SP-D is a valuable biomarker in ALI/ARDS.%目的 动态观测严重多发伤患者血浆中肺表面活性物质相关蛋白D(SP-D)水平并探讨它与创伤性急性肺损伤(ALI)/ARDS之间的关系及意义.方法 将36例严重多发伤患者分为多发伤后并发ALI/ARDS组20例(ALI/ARDS组)与多发伤后未并发ALI/ARDS组16例(非ALI/ARDS组).分别于伤后第1,3,7,14天收集外周血;同时计算PaO2/FiO2并行肺损伤评分;另12例体检健康者设为正常对照组.运用ELISA测定血浆SP-D的浓度.结果 ALI/ARDS组患者血浆SP-D水平显著高于正常对照组和非ALI/ARDS组(P<0.01);ALI/ARDS患者重度肺损伤组血浆SP-D水平明显高于中度肺损伤组(P<0.05);SP-D水平与其相应的PaO2/FiO2呈负相关关系(rs=-0.745,P<0.01).结论 严重多发伤

  13. Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation.

    Directory of Open Access Journals (Sweden)

    Jochen Grommes

    Full Text Available INTRODUCTION: Treatment of acute lung injury (ALI remains an unsolved problem in intensive care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored its effects on development of ALI and due to the importance of neutrophils in ALI also on neutrophil effector functions. METHODS: C57Bl/6 mice were exposed to aerosolized LPS (500 µg/ml for 30 min. The count of alveolar, interstitial, and intravasal neutrophils were assessed 4 h later by flow cytometry. Lung permeability changes were assessed by FITC-dextran clearance and albumin content in the BAL fluid. In vitro, we analyzed the effect of simvastatin on neutrophil adhesion, degranulation, apoptosis, and formation of reactive oxygen species. To monitor effects of simvastatin on bacterial clearance we performed phagocytosis and bacterial killing studies in vitro as well as sepsis experiments in mice. RESULTS: Simvastatin treatment before and after onset of ALI reduces neutrophil influx into the lung as well as lung permeability indicating the protective role of simvastatin in ALI. Moreover, simvastatin reduces the formation of ROS species and adhesion of neutrophils without affecting apoptosis, bacterial phagocytosis and bacterial clearance. CONCLUSION: Simvastatin reduces recruitment and activation of neutrophils hereby protecting from LPS-induced ALI. Our results imply a potential role for statins in the management of ALI.

  14. In vivo microscopy in a porcine model of acute lung injury.

    Science.gov (United States)

    Bickenbach, Johannes; Czaplik, Michael; Dembinski, Rolf; Pelosi, Paolo; Schroeder, Wolfgang; Marx, Gernot; Rossaint, Rolf

    2010-07-31

    Regional inhomogeneity and alveolar mechanics in a porcine model of acute lung injury (ALI) was evaluated using confocal laser scanning microscopy (CLSM). CLSM was performed through thoracic windows of the upper and lower lobes. Image quantification was conducted by use of a volume air index (VAI). Twelve anesthetized, mechanically ventilated pigs were randomized to non-injury (control group, n = 6) or ALI induced by surfactant depletion (ALI group, n = 6). CLSM was performed at baseline, after 1 h at 5 mbar and after 2 h at 15 mbar positive end-expiratory pressure (PEEP). Haemodynamics, respiratory mechanics and calculation of pulmonary ventilation-perfusion distribution by MIGET were determined. At baseline, VAI was not different. In the upper lobes, VAI significantly decreased in ALI compared to control group, with no changes after PEEP application. In the lower lobes, VAI significantly decreased in ALI compared to control group. Incremental PEEP significantly increased VAI in ALI, but not in control group. Haemodynamics were significantly compromised in the ALI group. A significant deterioration in oxygenation and ventilation-perfusion distribution could be seen being restored after PEEP adjustment. The VAI may help to assess regional inhomogeneity of the acutely injured lung.

  15. Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome.

    Science.gov (United States)

    Zhang, Yong; Li, Xiru; Grailer, Jamison J; Wang, Na; Wang, Mingming; Yao, Jianfei; Zhong, Rui; Gao, George F; Ward, Peter A; Tan, Dun-Xian; Li, Xiangdong

    2016-05-01

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically severe respiratory disorders, and there are currently no Food and Drug Administration-approved drug therapies. Melatonin is a well-known anti-inflammatory molecule, which has proven to be effective in ALI induced by many conditions. Emerging studies suggest that the NLRP3 inflammasome plays a critical role during ALI. How melatonin directly blocks activation of the NLRP3 inflammasome in ALI remains unclear. In this study, using an LPS-induced ALI mouse model, we found intratracheal (i.t.) administration of melatonin markedly reduced the pulmonary injury and decreased the infiltration of macrophages and neutrophils into lung. During ALI, the NLRP3 inflammasome is significantly activated with a large amount of IL-1β and the activated caspase-1 occurring in the lung. Melatonin inhibits the activation of the NLRP3 inflammasome by both suppressing the release of extracellular histones and directly blocking histone-induced NLRP3 inflammasome activation. Notably, i.t. route of melatonin administration opens a more efficient therapeutic approach for treating ALI.

  16. Analysis of lead content in herbal preparations in Malaysia.

    Science.gov (United States)

    Ang, H H; Lee, E L; Matsumoto, K

    2003-08-01

    In Malaysia, the phase 3 registration for traditional medicines was implemented on 1 January 1992 under the Control of Drugs and Cosmetics Regulation 1984, emphasizing quality, efficacy and safety (including the detection of the presence of heavy metals) in all pharmaceutical dosage forms of traditional medicine preparations. Therefore, a total of 100 products in various pharmaceutical dosage forms of a herbal preparation, were analysed for lead content using atomic absorption spectrophotometer. Results showed that 8% (eight products) possessed 10.64-20.72 ppm of lead, and therefore, do not comply with the quality requirement for traditional medicines in Malaysia. One of these products, M-Tongkat Ali (exhibited 10.64 +/-0.37 ppm of lead), was in fact already registered with the DCA Malaysia. The rest, Sukarno Tongkat Ali, Eurycoma Madu, Super Pill Tongkat Ali, Force Pill Tongkat Ali, Tender Pill Tongkat Ali, Super Pill Tongkat Ali Plus and Great Pill Tongkat Ali Plus have not registered with the DCA Malaysia and exhibited 12.24-20.72 ppm of lead. Although this study showed that only 92% of the products complied with the quality requirement for traditional medicines in Malaysia, however, they cannot be assumed safe from lead contamination because of batch-to-batch inconsistency.

  17. Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice

    Science.gov (United States)

    Soeiro-Pereira, Paulo V.; Gomes, Eliane; Neto, Antonio Condino; D' Império Lima, Maria R.; Alvarez, José M.; Portugal, Silvia; Epiphanio, Sabrina

    2016-01-01

    Malaria remains one of the greatest burdens to global health, causing nearly 500,000 deaths in 2014. When manifesting in the lungs, severe malaria causes acute lung injury/acute respiratory distress syndrome (ALI/ARDS). We have previously shown that a proportion of DBA/2 mice infected with Plasmodium berghei ANKA (PbA) develop ALI/ARDS and that these mice recapitulate various aspects of the human syndrome, such as pulmonary edema, hemorrhaging, pleural effusion and hypoxemia. Herein, we investigated the role of neutrophils in the pathogenesis of malaria-associated ALI/ARDS. Mice developing ALI/ARDS showed greater neutrophil accumulation in the lungs compared with mice that did not develop pulmonary complications. In addition, mice with ALI/ARDS produced more neutrophil-attracting chemokines, myeloperoxidase and reactive oxygen species. We also observed that the parasites Plasmodium falciparum and PbA induced the formation of neutrophil extracellular traps (NETs) ex vivo, which were associated with inflammation and tissue injury. The depletion of neutrophils, treatment with AMD3100 (a CXCR4 antagonist), Pulmozyme (human recombinant DNase) or Sivelestat (inhibitor of neutrophil elastase) decreased the development of malaria-associated ALI/ARDS and significantly increased mouse survival. This study implicates neutrophils and NETs in the genesis of experimentally induced malaria-associated ALI/ARDS and proposes a new therapeutic approach to improve the prognosis of severe malaria. PMID:27926944

  18. 全氟化碳治疗ALI的细胞生物学研究进展%Cytobiology study on treatment of acute lung injury with perfluorocarbon

    Institute of Scientific and Technical Information of China (English)

    曹璐; 李春笋; 梁志欣; 陈良安

    2015-01-01

    ALI/ARDS病情凶险,病死率高,是临床常见的危重症,目前尚无特效的治疗方法.研究显示应用全氟化碳的液体通气对ALI/ARDS的治疗效果优于常规机械通气,且全氟化碳能拮抗ALI/ARDS导致的炎症反应,但其抗炎的机制仍不明确.本文就全氟化碳治疗ALI的细胞生物学研究进展作一综述.%Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high mortality,and there are no specific strategies for treatment currently.The studies have shown that liquid ventilation with perfluorocarbon has more advantages than conventional mechanical ventilation in the treatment of ALI/ARDS.Perfluorocarbon can inhibit inflammatory response caused by ALI/ARDS.However,the anti-inflammatory mechanism has not been completely elucidated.This review aims to summarize the cytobiology study on the treatment of ALI/ARDS with perfluorocarbon.

  19. Human models of acute lung injury

    Directory of Open Access Journals (Sweden)

    Alastair G. Proudfoot

    2011-03-01

    Full Text Available Acute lung injury (ALI is a syndrome that is characterised by acute inflammation and tissue injury that affects normal gas exchange in the lungs. Hallmarks of ALI include dysfunction of the alveolar-capillary membrane resulting in increased vascular permeability, an influx of inflammatory cells into the lung and a local pro-coagulant state. Patients with ALI present with severe hypoxaemia and radiological evidence of bilateral pulmonary oedema. The syndrome has a mortality rate of approximately 35% and usually requires invasive mechanical ventilation. ALI can follow direct pulmonary insults, such as pneumonia, or occur indirectly as a result of blood-borne insults, commonly severe bacterial sepsis. Although animal models of ALI have been developed, none of them fully recapitulate the human disease. The differences between the human syndrome and the phenotype observed in animal models might, in part, explain why interventions that are successful in models have failed to translate into novel therapies. Improved animal models and the development of human in vivo and ex vivo models are therefore required. In this article, we consider the clinical features of ALI, discuss the limitations of current animal models and highlight how emerging human models of ALI might help to answer outstanding questions about this syndrome.

  20. Chest sonography: a useful tool to differentiate acute cardiogenic pulmonary edema from acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Soldati Gino

    2008-04-01

    Full Text Available Abstract Background Differential diagnosis between acute cardiogenic pulmonary edema (APE and acute lung injury/acute respiratory distress syndrome (ALI/ARDS may often be difficult. We evaluated the ability of chest sonography in the identification of characteristic pleuropulmonary signs useful in the diagnosis of ALI/ARDS and APE. Methods Chest sonography was performed on admission to the intensive care unit in 58 consecutive patients affected by ALI/ARDS or by acute pulmonary edema (APE. Results Ultrasound examination was focalised on finding in the two groups the presence of: 1 alveolar-interstitial syndrome (AIS 2 pleural lines abnormalities 3 absence or reduction of "gliding" sign 4 "spared areas" 5 consolidations 6 pleural effusion 7 "lung pulse". AIS was found in 100% of patients with ALI/ARDS and in 100% of patients with APE (p = ns. Pleural line abnormalities were observed in 100% of patients with ALI/ARDS and in 25% of patients with APE (p All signs, except the presence of AIS, presented a statistically significant difference in presentation between the two syndromes resulting specific for the ultrasonographic characterization of ALI/ARDS. Conclusion Pleuroparenchimal patterns in ALI/ARDS do find a characterization through ultrasonographic lung scan. In the critically ill the ultrasound demonstration of a dyshomogeneous AIS with spared areas, pleural line modifications and lung consolidations is strongly predictive, in an early phase, of non-cardiogenic pulmonary edema.

  1. Subsurface Imaging by UWB Radar: Application to Humanitarian Demining in Cambodia

    Science.gov (United States)

    Sato, Motoyuki

    Ground Penetrating Radar (GPR) has been widely used applications which include detection of subsurface facilities, concrete inspection and archaeology. Among these applications, humanitarian demining is still difficult task. Since 2002, we have developed a new hand-held land mine detection dual-sensor ALIS. ALIS is equipped with a metal detector and a GPR, and it has a sensor tracking system, which can record the GPR and Metal detector signal with its location. ALIS can process the data and is used for image re-construction by migration processing. ALIS is the only one mine detection system in the world which can visualize the GPR image by hand scanning. We found that the migration processing can reduce the clutter and gives us clear images of buried mines. After several tests of ALIS in mine affected courtiers, operation of ALIS in mine fields in Cambodia started in summer 2009. Two sets of ALIS have been operated in Cambodia and more than 77 antipersonnel mines have been detected and 137,000m2 farmland was cleaned.

  2. PAVING THE WAY FOR INTERRELIGIOUS DIALOGUE, TOLERANCE, AND HARMONY: Following Mukti Ali’s Path

    Directory of Open Access Journals (Sweden)

    Faisal Ismail

    2012-01-01

    Full Text Available A known Indonesian Muslim scholar Mukti Ali (1923-2004 was very much concerned with dialogue, tolerance, and harmony among the people of different traditions, cultures, and religions. In his many academic works, he stressesed the importance of promoting, strengthening, and maintaining intercultural and interreligious dialogue, tolerance, and harmony. Not only did he produce various academic works, but also made efforts in putting his intercultural and interreligious ideas into practice. Both as a scholar and expert in the comparative study of religions and as Minister of Religious Affairs of the Republic of Indonesia (1971-1978, Mukti Ali endlessly promoted intercultural and interreligiuos diologue, tolerance, and harmony. Realizing that Indonesia is a pluralistic society, Mukti Ali adopted an approach called ‘agree in disagreement’ in the effort of creating and supporting tolerance, harmony, and security among people of different religious traditions. This paper will highlight the principles and values which Mukti Ali struggled for during his long administrative and academic careers.[Mukti Ali (1923-2004 adalah salah seorang intelektual Muslim ternama di Indonesia. Dia dedikasikan hidupnya untuk menyemai dialog, toleransi dan kehidupan harmonis antar tradisi, budaya dan agama yang beragam. Dalam berbagai karya akademiknya, Mukti Ali selalu menekankan pentingnya kehidupan harmonis dan toleransi antar pemeluk agama dan budaya. Lebih dari itu, dia melampaui hanya sekedar batas pemikiran dengan mengimplementasikan gagasan-gagasannya tersebut. Sebagai seorang ilmuwan dengan keahlian perbandingan agama dan sebagai Menteri Agama RI (1971-1978, Mukti Ali dengan kukuh memperjuangkan dialog, toleransi dan kehidupan harmonis antar agama dan budaya. Mukti Ali sadar, Indonesia adalah negara yang plural, karena itu dia menawarkan pendekatan “agree in disagreement” untuk menciptakan harmoni dan toleransi tersebut. Tulisan ini mengulas prinsip dan

  3. Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.

    Directory of Open Access Journals (Sweden)

    Fiona E Lovegrove

    2008-05-01

    Full Text Available Although acute lung injury (ALI is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria (CM; however, no model of malaria-induced lung injury has been definitively established. This study used bronchoalveolar lavage (BAL, histopathology and gene expression analysis to examine the development of ALI in mice infected with Plasmodium berghei ANKA (PbA. BAL fluid of PbA-infected C57BL/6 mice revealed a significant increase in IgM and total protein prior to the development of CM, indicating disruption of the alveolar-capillary membrane barrier-the physiological hallmark of ALI. In contrast to sepsis-induced ALI, BAL fluid cell counts remained constant with no infiltration of neutrophils. Histopathology showed septal inflammation without cellular transmigration into the alveolar spaces. Microarray analysis of lung tissue from PbA-infected mice identified a significant up-regulation of expressed genes associated with the gene ontology categories of defense and immune response. Severity of malaria-induced ALI varied in a panel of inbred mouse strains, and development of ALI correlated with peripheral parasite burden but not CM susceptibility. Cd36(-/- mice, which have decreased parasite lung sequestration, were relatively protected from ALI. In summary, parasite burden and CD36-mediated sequestration in the lung are primary determinants of ALI in experimental murine malaria. Furthermore, differential susceptibility of mouse strains to malaria-induced ALI and CM suggests that distinct genetic determinants may regulate susceptibility to these two important causes of malaria-associated morbidity and mortality.

  4. Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations

    Institute of Scientific and Technical Information of China (English)

    Hsing I Chen

    2011-01-01

    Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) can be associated with various disorders.Recent investigation has involved clinical studies in collaboration with clinical investigators and pathologists on the pathogenetic mechanisms of ALl or ARDS caused by various disorders.This literature review includes a brief historical retrospective of ALI/ARDS, the neurogenic pulmonary edema due to head injury, the long-term experimental studies and clinical investigations from our laboratory, the detrimental role of NO, the risk factors, and the possible pathogenetic mechanisms as well as therapeutic regimen for ALI/ARDS.

  5. Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

    Directory of Open Access Journals (Sweden)

    Lunjie Lu

    2016-01-01

    Full Text Available Tanshinone IIA sodium sulfonate (TSS is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrhizinate (MI in D-galactosamine- (D-Gal- induced acute liver injury (ALI in mice. The potential regulatory mechanisms of TSS on ALI were also examined. Our results may provide a basis for the development of novel therapeutics for ALI.

  6. SPOLNO NADLEGOVANJE NA DELOVNEM MESTU

    OpenAIRE

    Rubič, Gašper

    2016-01-01

    V diplomskem delu smo v uvodu predstavili problem spolnega nadlegovanja na delovnem mestu in predstavili podjetje TEKSTIL d.d. V nadaljevanju smo z anketo raziskali, ali problem spolnega nadlegovanja na delovnem mestu v obravnavanem podjetju obstaja in če, kako se nanj odziva okolje. V teoretičnem delu smo nadaljevali in predstavili definicijo spolnega nadlegovanja, ki je kakršna koli oblika nezaželenega verbalnega in neverbalnega ali fizičnega ravnanja spolne narave z učinkom ali nameno...

  7. Dynamic Personal Identity and the Dynamic Identity Grid: How Theory and Concept Can Transform Information into Knowledge and Secure the American Homeland

    Science.gov (United States)

    2008-09-01

    Insights IV, no. 4 (April 2005), http://www.ccc.nps.navy.mil/si/2005/Apr/sagemanApr05.asp (accessed August 1, 2008); Dan Murphy, “How Al Qaeda Lit the Bali ...Gufron brothers--Ali, Amrozi, Ali Imron and Ali Fauzi--were involved in the Bali nightclub bombings.40 The millennium plot and the 9/11 attack... phenomena have been discarded. The genealogical structure of Arab-Muslim names and the fact that terrorists have a high degree of family connectedness has

  8. Involvement of the p38 mitogen-activated protein kinase signal transduction pathway in burns-induced lung injury

    Institute of Scientific and Technical Information of China (English)

    CHEN Xu-lin; XIA Zhao-fan; WEI Duo; WANG Yong-jie; WANG Chang-rong

    2005-01-01

    @@ Acute lung injury (ALI) is a leading complication in extensively burned patients, especially those with inhalation injury.1 It can cause hypoxia resulting in injury of remote organs and dysfunction. P38 mitogen-activated protein kinase (p38 MAPK) is a stress activated protein kinase in the MAPK family.2 Most of the previous studies have demonstrated that p38 MAPK signal transduction pathway mediated ALI in rats with acute severe pancreatitis, sepsis etc.3-5 However, there is little information regarding the role of p38 MAPK signal transduction pathway in ALI after severe burn trauma.

  9. Od djevojčice s ulice do rimske božice: stvaranje višestrukih vizualnih Alica od 1858. do 1872.

    OpenAIRE

    Heller, Erga

    2016-01-01

    Viktorijanske prikaze djetinjstva nalazimo u raznolikim kulturnim tekstovima, i to u različitim verbalnim i vizualnim oblicima – od književnih opisa do samostalnih slika. Aličine pustolovine u Čudozemskoj Lewisa Carrolla (1865.) u tome smislu ne predstavljaju iznimku. Međutim, Aličin lik jedan je od prvih koji se prometnuo u intermedijsku figuru, pri čemu je Alica postala junakinjom fantastične književnosti kao i ikonom popularne kulture. Ovaj se rad usmjerava na tri oblika Aličina umjetničko...

  10. Jordaania nägi esimest korda naiseneseõhkijat / Kaarel Kaas

    Index Scriptorium Estoniae

    Kaas, Kaarel, 1978-

    2005-01-01

    Jordaania televisioonis esines ülestunnistusega naisenesetaputerrorist Sajida Mubarak al-Rishaw, kelle ülesandeks oli end õhkida koos oma mehe Ali Hussein al-Shumariga Ammani kesklinna hotellis Radisson SAS

  11. Noonan syndrome

    Science.gov (United States)

    ... chest shape (most often a sunken chest called pectus excavatum) Webbed and short-appearing neck Exams and Tests ... to consider genetic counseling before having children. Images Pectus excavatum References Ali O, Donohoue PA. Noonan syndrome. In: ...

  12. ALICE - ARC integration

    DEFF Research Database (Denmark)

    Anderlik, Csaba; Gregersen, Anders Rhod; Kleist, Josva;

    AliEn or Alice Environment is the Gridware developed and used within the ALICE collaboration for storing and processing data in a distributed manner. ARC (Advanced Resource Connector) is the Grid middleware deployed across the Nordic countries and gluing together the resources within the Nordic...... Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The interoperation has two aspects, one is the data...... management part and the second the job management aspect. The first aspect was solved by using dCache across NDGF to handle data. dCache provides support for several data management tools (among them for xrootd the tools used by AliEn) using the so called "doors". Therefore, we will concentrate on the second...

  13. 3Corners of the World / Joosep Sang

    Index Scriptorium Estoniae

    Sang, Joosep

    2009-01-01

    Arvustused : Robert Jürjendal, Petri Kuljuntausta, David Rothenberg. 3Corners of the World. [Tallinn] : Terra Nova Music, 2008. Nadia ja Fragile. Uhke ali. [Tallinn] : Nadia & Fragile, 2008. UMA. Civitas Soli. [Tallinn] : Elwood, 2008. Uutest heliplaatidest

  14. 新生儿急性肺损伤

    Institute of Scientific and Technical Information of China (English)

    蔡栩栩; 韩玉昆

    2003-01-01

    @@ 20世纪90年代,人们对急性呼吸窘迫综合征(ARDS)的认识逐步深化,提出了急性肺损伤( ALI)的概念,认为ALI与ARDS同属于一个病理生理过程,ARDS是ALI发展的严重阶段,并认识到ALI/ARDS是全身炎症反应综合征(SIRS)在肺部的表现,是致炎和抗炎之间平衡失调的结果.但有关新生儿ALI/ARDS的研究起步较晚,本文就近年来有关新生儿ALI/ARDS的临床和基础研究加以综述.

  15. Simulatsioon, situatsioon, kaos / Rain Tolk

    Index Scriptorium Estoniae

    Tolk, Rain, 1977-

    2004-01-01

    Provokatiivse teleprogrammi "Ekskursioon" (Kanal 2) võrdlus ameerika ja inglise analoogidega - "Da Ali G Show" ja "The Awful Truth & TV-Nation". Lisatud Kanal 2 programmijuhi Olle Mirme kommentaar ja "Provokatiivseid saateid ja momente eesti teleajaloos" lk. 126

  16. Dicty_cDB: VSD225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available skitlvlcviqkvkskvtfsdq sprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---VYINNVKSTSRR**lqsi...*lsdkentgrermvftsiskitlvlcviqkvkskvtfsdq sprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---...iqkvkskvtf sdqsprnapiygqrlppmpvplfk*ihiklkq Homology vs CSM-cDNA Score E Sequences producing significant ali

  17. Dicty_cDB: VSD437 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available slpskvskvv*idyhpqvlviw swlpskrvnqn*erkfalv*lsdkentgrermvftsiskitlvlcviqkvkskvtfsdqs prnapiygqrlppmpvplfk*IHI...ermvftsiskitlvlcviqkvkskvtfsdqs prnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---hk*cqkhkps...iyfednagvmcnpkgevkgnilg pvakecsdlgqrlppmpvp Homology vs CSM-cDNA Score E Sequences producing significant ali

  18. Nucleotide sequence of the coat protein genes of alstroemeria mosaic virus and amazon lily mosaic virus, a tentative species of genus potyvirus.

    Science.gov (United States)

    Fuji, S; Terami, F; Furuya, H; Naito, H; Fukumoto, F

    2004-09-01

    The nucleotide sequences of the 3' terminal region of the genomes of Alstroemeria mosaic virus (AlsMV) and the Amazon lily mosaic virus (ALiMV) have been determined. These sequences contain the complete coding region of the viral coat protein (CP) gene followed by a 3'-untranslated region (3'-UTR). AlsMV and ALiMV share 74.9% identity in the amino acid sequence of the CP, and 55.6% identity in the nucleotide sequence of the 3'-UTR. Phylogenetic analysis of these CP genes and 3'-UTRs in relation to those of 79 potyvirus species revealed that AlsMV and ALiMV should be assigned to the Potato virus Y (PVY) subgroup. AlsMV and ALiMV were concluded to have arisen independently within the PVY subgroup.

  19. Saudi Entrepreneurs Delegation Visits China

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Adelegation of Saudi entrepreneurs headed by Abdul-Rahman Ali AlJeraisy, president of the Saudi Arabia-China Friendship Association (SACFA) and chairman of the Council of Saudi Chambers of Commerce and Industry (CSCCI),

  20. Forschungsschwerpunkte im Institut für Kulturgeographie der Universität Frankfurt am Main am Ende der 80er Jahre

    Directory of Open Access Journals (Sweden)

    Klaus Wolf

    1987-12-01

    Full Text Available The review of research work of the Institute exposes the spheres of tourism population development and sub-urbanisation with ali accompanying economic and non-economic phenomena.

  1. On Certain Classes of Biharmonic Mappings Defined by Convolution

    Directory of Open Access Journals (Sweden)

    J. Chen

    2012-01-01

    Full Text Available We introduce a class of complex-valued biharmonic mappings, denoted by , together with its subclass , and then generalize the discussions in Ali et al. (2010 to the setting of and in a unified way.

  2. PODPORA MOBILNEGA POSLOVANJA S CELOVITIMI INFORMACIJSKIMI REŠITVAMI

    OpenAIRE

    Kos, Gašper

    2013-01-01

    Mobilno poslovanje je podjetjem dodalo nove dimenzije. Vso poslovanje je sedaj na dosego mobilnega telefona ali tabličnega računalnika. To tudi predstavlja konkurenčno prednost podjetij, ki izvajajo m-poslovanje.

  3. Plaadid / Margus Kiis

    Index Scriptorium Estoniae

    Kiis, Margus

    2002-01-01

    Uutest plaatidest Nightlight Dou "La Fiesta Del Sol", Yves Montand "Ses Plus Grands Succes", Natalia Oreiro "Tu veneno", Daishin Kashimoto "Passionata", Mike Oldfield "Tres Lunas", Ali G Indiahouse "Da Soundtrack", Ronan Keating "Destination", Roger Waters "Flickering Flame"

  4. Belgia kunstikoguja segab Kuressaaret kunstiafääri / Taavi Tuisk

    Index Scriptorium Estoniae

    Tuisk, Taavi

    2008-01-01

    Mehhikos elav belglane Francis Alys (1959) süüdistab 1997. a. Saaremaa biennaali korraldajaid temale kuulunud ja biennaalil eksponeeritud tööde (Jean-Jacques Henner' maali koopiad) äravahetamises

  5. 2 October 2012 - Egyptian Academy of Scientific Research and Technology President M. Al Sherbiny signing a protocol agreement with CERN Director-General R. Heuer, witnessed by Ambassador to the UN W. Bassim. This signature is followed by the signature of an MoU with ALICE and CMS Collaborations.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    Where present: ALICE Collaboration: CP. Giubellino, F. Carminati, C. Decosse, and A. N. Tawfik CMS Collaboration: T. Camporesi A. Charkiewicz, A. De Roeck, A. Petrilli, A. Sharma with S. Aly, Y. Assran, M. Attia, R. Masod and A. Radi

  6. Dicty_cDB: VFO754 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FIIAIVMLDGLXFXTLHSIFGITYIMFGIGFNSIWCTXSLPLEXN*swxs nfp*yvplvrwslyicfixccxhxwygtspssxrcy Translated Amino Aci...N*swxs nfp*yvplvrwslyicfixccxhxwygtspssxrcy Homology vs CSM-cDNA Score E Sequences producing significant ali

  7. Sesamin Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibition of TLR4 Signaling Pathways.

    Science.gov (United States)

    Qiang, Li; Yuan, Jiang; Shouyin, Jiang; Yulin, Li; Libing, Jiang; Jian-An, Wang

    2016-02-01

    Recent studies suggested that TLR4 signaling pathways played an important role in the development of LPS-induced acute lung injury (ALI). Sesamin, a sesame lignan exacted from sesame seeds, has been shown to exhibit significant anti-inflammatory activity. The purpose of this study was to investigate the anti-inflammatory effects of sesamin on LPS-induced ALI in mice. Mice ALI model was induced by intratracheal instillation of LPS. Sesamin was given 1 h after LPS challenge. Our results showed that sesamin inhibited LPS-induced lung pathological change, edema, and myeloperoxidase (MPO) activity. Sesamin suppressed LPS-induced inflammatory cytokines TNF-α, IL-6, and IL-1β production. Furthermore, sesamin inhibited LPS-induced TLR4 expression and NF-κB activation. In conclusion, the results of this study indicated that sesamin protected against LPS-induced ALI by inhibition of TLR4 signaling pathways.

  8. Generalized average local ionization energy and its representations in terms of Dyson and energy orbitals.

    Science.gov (United States)

    Kohut, Sviataslau V; Cuevas-Saavedra, Rogelio; Staroverov, Viktor N

    2016-08-21

    Ryabinkin and Staroverov [J. Chem. Phys. 141, 084107 (2014)] extended the concept of average local ionization energy (ALIE) to correlated wavefunctions by defining the generalized ALIE as Ī(r)=-∑jλj|fj(r)|(2)/ρ(r), where λj are the eigenvalues of the generalized Fock operator and fj(r) are the corresponding eigenfunctions (energy orbitals). Here we show that one can equivalently express the generalized ALIE as Ī(r)=∑kIk|dk(r)|(2)/ρ(r), where Ik are single-electron removal energies and dk(r) are the corresponding Dyson orbitals. The two expressions for Ī(r) emphasize different physical interpretations of this quantity; their equivalence enables one to calculate the ALIE at any level of ab initio theory without generating the computationally expensive Dyson orbitals.

  9. 超声技术在急性肺损伤及急性呼吸窘迫综合征诊治中的研究进展%The research progress of ultrasound in the diagnosis and therapy of acute pulmonary injury and acute respiratory distress syndrome

    Institute of Scientific and Technical Information of China (English)

    冯聪; 周璇; 黎檀实; 吕发勤

    2013-01-01

    Acute lung injury/Acute respiratory distress syndrome(ALI/ARDS) is a common critical disease with a high mortality rate. Effective diagnostic methods and therapy are still rely on the arterial blood-gas analysis, chest X-ray/computed tomography(CT) ,mechanical ventilation and drug. The study on ALI/ARDS in early diagnosis, evaluating severity and drug therapy are the main direction of Critical Care Medicine. The rapid development of ultrasound brought lots of new ideas and options for diagnosis and therapy and achieved positive effects in basic and clinical studies on ALI/ARDS. This article outlines the recent advances of ultrasonography in the diagnosis and therapy of ALI/ARDS.

  10. [Tänavuse Whitbreadi auhinna pälvis Hilary Spurling biograafia "Matisse the master" eest] / Lauri Eesmaa

    Index Scriptorium Estoniae

    Eesmaa, Lauri

    2006-01-01

    Romaanikategooria auhinna sai Ali Smith romaaniga "The accidental", luulekategoorias Christopher Logue luulekoguga "Cold calls", parima debüüdi tegi Tash Aw romaaniga "The harmony silk factory" ning lasteraamatu kategooria auhinna sai Kate Thompsoni teos "The new policeman"

  11. Gene : CBRC-MMUS-11-0132 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available ERASE) (MONOBUTYRASE) (COCAINE ESTERASE) (PROCAINE ESTERASE) (METHYLBUTYRASE) ......d library, clone:A430088E12 product:similar to CARBOXYLESTERASE PRECURSOR (EC 3.1.1.1) (ALI-ESTERASE) (B-EST

  12. Põhjapanevad uuendused Brunei naftasultanaadis / Allan Espenberg

    Index Scriptorium Estoniae

    Espenberg, Allan

    2004-01-01

    Parlamenti ehk Seadusandlikku Kogu pole Bruneis eksisteerinud 42 aastat, sest 1962. a. saatis valitseja Omar Ali Saifuddin selle laiali. 25. sept. tuli 21-liikmeline parlament kokku. Bruneist kui heaolu riigist

  13. Anti-inflammatory effects of eugenol on lipopolysaccharide-induced inflammatory reaction in acute lung injury via regulating inflammation and redox status.

    Science.gov (United States)

    Huang, Xianfeng; Liu, Yuanyuan; Lu, Yingxun; Ma, Chunhua

    2015-05-01

    Acute lung injury (ALI) represents a clinical syndrome that results from complex responses of the lung to a multitude of direct and indirect insults. This study aims to evaluate the possible mechanisms responsible for the anti-inflammatory effects of eugenol (EUL) on lipopolysaccharide (LPS)-induced inflammatory reaction in ALI. ALI was induced in mice by intratracheal instillation of LPS (0.5 mg/kg), and EUL (5, and 10 mg/kg) was injected intraperitoneally 1h prior to LPS administration. After 6h, bronchoalveolar lavage fluid (BALF) and lung tissue were collected. The findings suggest that the protective mechanism of EUL may be attributed partly to decreased production of proinflammatory cytokines through the regulating inflammation and redox status. The results support that use of EUL is beneficial in the treatment of ALI.

  14. Pommipanija vabastamine tekitab tõsiseid pingeid / Tiina Tamman

    Index Scriptorium Estoniae

    Tamman, Tiina, 1948-

    2009-01-01

    Lockerbié lennukatastroofi korraldamise eest vangi mõistetud Abdul Baset Ali al-Megrahi vabastamine Šotimaal on USA-s kaasa toonud proteste. Suurbritannia kinnitusel Šotimaale otsuse tegemisel survet ei avaldatud

  15. Protective Effect of Rhubarb on Endotoxin-Induced Acute Lung Injury

    Institute of Scientific and Technical Information of China (English)

    李春盛; 周景; 桂培春; 何新华

    2001-01-01

    To approach the mechanism of lipopolysaccharide (LPS) in causing acute lung injury (ALI) and the protective effect of rhubarb and dexamethasone, lung specimens were examined with macroscopy, microscopy, electron microscopy and the biological markers of ALI including lung wet/dry weight, the rate of neutrophils and protein content in the pulmonary alveolar lavage fluid, pulmonary capillary permeability and pulmonary alveolar permeability index were observed. The mechanism of the ALI is mainly due to direct injury of alveolar epithelium and pulmonary vascular endothelium. Rhubarb and dexamethasone could significantly reduce the edema of the lung tissue, decrease the red blood cell exudation, neutrophil infiltration and plasma protein exudation in the alveoli and all the biological markers in comparison with the ALI model rats, indicating they have protective action on vascular endothelium and alveolar epithelium.

  16. Rural Health Information Hub

    Science.gov (United States)

    ... be the best treatment. Exploring High Infant and Maternal Mortality Rates in the Rural U.S. with Dr. Ali ... reasons behind the United States’ high infant and maternal mortality rates. A Professor of Global Health at the ...

  17. Berliini biennal : teater ühel tänaval : biennaalikunst / Rael Artel

    Index Scriptorium Estoniae

    Artel, Rael, 1980-

    2006-01-01

    IV Berliini kaasaegse kunsti biennaal "Of Mice and Men / Hiirtest ja inimestest" Berliinis Auguststrasse ümbruses kuni 28. V. Kuraatorid Maurizio Cattelan, Massimiliano Gioni ja Ali Subotnick. Väljapanekust, toimumiskohast

  18. Phenotypic and physiologic variability in nasal epithelium cultured from smokers and non-smokers exposed to secondhand tobacco smoke

    Science.gov (United States)

    The emergence of air-liquid interface (ALI) culturing of mammalian airway epithelium is a recent innovation for experimental modeling of airway epithelial development, function, and pathogenic mechanisms associated with infectious agent and irritant exposure. This construct provi...

  19. A new species of Begonia L.(Begoniaceae) from Yunnan, Chinas Y. Y. Qian; New species; China%云南秋海棠属一新种

    Institute of Scientific and Technical Information of China (English)

    钱义咏

    2001-01-01

    @@ Begonia menglianensis Y. Y. Qian, sp. nov. (Sect. Platycentrum Ser. Cathayanae). Fig. 1 Habitu B. versicolori lrmsch. similis, sed foliorum laminis supra glabris, florum staminatorum tepalis 4, capsularum alis majoribus ligulatis, 20~22 mm longis differt.

  20. An improved heuristic for one-machine scheduling with delays constraints

    Institute of Scientific and Technical Information of China (English)

    杜东雷; 韩继业; 陈礴

    1997-01-01

    An improved heuristic is proposed for one-machine scheduling problem with delay constraints,thus an open problem raised by Wikum et al.is solved.The heuristic solves the corresponding unit-execution-time problem optimally.

  1. Filme kaladest : "Maelströmi" külm langemine, "Bo Ba Bu" kiviaegne röhkimine ja vanameister Imamura "Soe vesi punase silla all" / Erkki Luuk

    Index Scriptorium Estoniae

    Luuk, Erkki, 1971-

    2001-01-01

    Temaatiliselt koos vaadeldakse kolme erineva kultuuritaustaga režissööri filme : kanadalase Denis Villeneuve "Maelström", usbeki Ali Hamrajevi "Bo Ba Bu" ja jaapanlase Shohei Imamura "Soe vesi punase silla all"

  2. Vene oligarh vallandas meediajuhte / Ksenia Repson

    Index Scriptorium Estoniae

    Repson, Ksenia

    2011-01-01

    Venemaa oligarh Ališer Usmanov vallandas ASi Kommersant Holding peadirektori Andrei Galijevi ja ajakirja Kommersant-Vlast peatoimetaja Maksim Kovalski, tuues põhjuseks Venemaa peaministri Vladimir Putini solvamise

  3. В российских СМИ начались чистки / Ксения Репсон

    Index Scriptorium Estoniae

    Репсон, Ксения

    2011-01-01

    Venemaa oligarh Ališer Usmanov vallandas ASi Kommersant Holding peadirektori Andrei Galijevi ja ajakirja Kommersant-Vlast peatoimetaja Maksim Kovalski, tuues põhjuseks Venemaa peaministri Vladimir Putini solvamise

  4. Disease: H01301 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ncodes tight-junction protein causes this syndrome. Nervous system disease hsa045...vich AJ, Ali B, Al-Gazali L, Walsh CA A homozygous mutation in the tight-junction protein JAM3 causes

  5. Piperine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Modulating NF-κB Signaling Pathways.

    Science.gov (United States)

    Lu, Ying; Liu, Jingyao; Li, Hongyan; Gu, Lina

    2016-02-01

    Piperine, one of the active components of black pepper, has been reported to have antioxidant and anti-inflammatory activities. However, the effects of piperine on lipolysaccharide (LPS)-induced acute lung injury (ALI) have not been reported. Thus, the protective effects of piperine against LPS-induced ALI were investigated in this study. LPS-induced lung injury was assessed by histological study, myeloperoxidase (MPO) activity, and inflammatory cytokine production. Our results demonstrated that piperine attenuated LPS-induced MPO activity, lung edema, and inflammatory cytokines TNF-α, IL-6, and IL-1β production. Histological studies showed that piperine obviously attenuated LPS-induced lung injury. In addition, piperine significantly inhibited LPS-induced NF-κB activation. In conclusion, our results demonstrated that piperine had a protective effect on LPS-induced ALI. The anti-inflammatory mechanism of piperine is through inhibition of NF-κB activation. Piperine may be a potential therapeutic agent for ALI.

  6. Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.

    Directory of Open Access Journals (Sweden)

    Shunying Jin

    Full Text Available Immune-complexes play an important role in the inflammatory diseases of the lung. Neutrophil activation mediates immune-complex (IC deposition-induced acute lung injury (ALI. Components of gamma amino butyric acid (GABA signaling, including GABA B receptor 2 (GABABR2, GAD65/67 and the GABA transporter, are present in the lungs and in the neutrophils. However, the role of pulmonary GABABR activation in the context of neutrophil-mediated ALI has not been determined. Thus, the objective of the current study was to determine whether administration of a GABABR agonist, baclofen would ameliorate or exacerbate ALI. We hypothesized that baclofen would regulate IC-induced ALI by preserving pulmonary GABABR expression. Rats were subjected to sham injury or IC-induced ALI and two hours later rats were treated intratracheally with saline or 1 mg/kg baclofen for 2 additional hours and sacrificed. ALI was assessed by vascular leakage, histology, TUNEL, and lung caspase-3 cleavage. ALI increased total protein, tumor necrosis factor α (TNF-α and interleukin-1 receptor associated protein (IL-1R AcP, in the bronchoalveolar lavage fluid (BALF. Moreover, ALI decreased lung GABABR2 expression, increased phospho-p38 MAPK, promoted IκB degradation and increased neutrophil influx in the lung. Administration of baclofen, after initiation of ALI, restored GABABR expression, which was inhibited in the presence of a GABABR antagonist, CGP52432. Baclofen administration activated pulmonary phospho-ERK and inhibited p38 MAPK phosphorylation and IκB degradation. Additionally, baclofen significantly inhibited pro-inflammatory TNF-α and IL-1βAcP release and promoted BAL neutrophil apoptosis. Protective effects of baclofen treatment on ALI were possibly mediated by inhibition of TNF-α- and IL-1β-mediated inflammatory signaling. Interestingly, GABABR2 expression was regulated in the type II pneumocytes in lung tissue sections from lung injured patients, further suggesting

  7. Relationship between the expression of Toll-like receptor 2 and 4 in mononuclear cells and postoperative acute lung injury in orthotopic liver transplantation

    Institute of Scientific and Technical Information of China (English)

    CHI Xin-jin; CAI Jun; LUO Chen-fang; CHENG Nan; HEI Zi-qing; LI Shang-rong; LUO Gang-jian

    2009-01-01

    Background The aim of this study was to investigate the potential relationship between the dynamic expression of Toll-like receptor 2 and 4 (TLR2/4) in peripheral blood mononuclear cells as well as changes in serum concentration of inflammatory factors and acute lung injury (ALl) in patients after orthotopic liver transplantation (OLT).Methods The peripheral blood samples of 27 patients (23 men and 4 women with ASA Ⅲ to Ⅳ) who received OLT were collected for measurement of TLR2/4 at T1 (after induction of anesthesia), T2 (25 minutes after anhepatic phase), T3 (3 hours after graft reperfusion) and T4 (24 hours after graft reperfusion). The expression of TLR2/4 in mononuclear cells was measured by flow cytometry. The serum concentrations of tumor necrosis factor (TNF)-a, intedeukin (IL)-113 and IL-8 were measured by enzyme-linked irnmunosorbent assay (ELISA). Twenty-seven patients were assigned to ALI group (n=9) and non-ALI group (n=18) according to the diagnostic criteria of ALI. The expression of TLR2/4 in the ALl group or non-ALI group was analyzed.Results Compared to the non-ALI group, the volumes of blood loss, ascites, total output and transfused red blood cells were higher in the ALI group, and the anhepallc phase lasted longer (P0.05). The expression of TLR2/4 in mononuclear cells increased significantly at T3 and 14 in the ALI group (P<0.05, P<0.01). A positive correlation was noted between the expression of TLR4 in mononuclear cells and the serum concentrations of TNF-α, IL-1β (P=0.041, P=0.046) in the ALl group. In the non-ALI group, statistical results showed that the expression level of TLR2/4 in mononuclear cells was not significantly different during the peri-operative period of OLT (besides TLR4 expression at T4). Compared to the non-ALI group, the increasing amplitude of TLR2/4 expression in mononuclear cells was more significant in the ALI group. The patients whose TLR2/4 expression in mononuclear cells exceeded that at T1 by one time were

  8. cDNA cloning and bacterial expression of a PL-14 alginate lyase from a herbivorous marine snail Littorina brevicula.

    Science.gov (United States)

    Rahman, Mohammad Matiur; Wang, Ling; Inoue, Akira; Ojima, Takao

    2012-10-01

    Herbivorous marine snails like Littorina species are known to possess alginate lyases in their digestive tracts. The Littorina enzymes have been identified as endolytic polymannuronate (poly(M)) lyases (EC 4.2.2.3); however, it is still unclear which polysaccharide-lyase family (PL) the Littorina enzymes belong to, since no complete primary structure of Littorina enzymes has been determined. Thus, in the present study, we analyzed the primary structure of LbAly28, a 28kDa alginate lyase isozyme of Littorina brevicula, by the cDNA method. LbAly28 cDNAs were amplified by PCR followed by 5'- and 3'-RACE PCRs from the L. brevicula hepatopancreas cDNA. A cDNA covering entire coding region of LbAly28 consisted of 1129bp and encoded an amino-acid sequence of 291 residues. The deduced amino-acid sequence comprised an initiation methionine, a putative signal peptide of 14 residues, a propeptide-like region of 16 residues, and a mature LbAly28 domain of 260 residues. The mature LbAly28 domain showed 43-53% amino-acid identities with other molluscan PL-14 enzymes. The catalytically important residues in PL-14 enzymes, which were identified in the Chlorella virus glucuronate-specific lyase vAL-1 and Aplysia poly(M) lyase AkAly30, were also conserved in LbAly28. Site-directed mutagenesis regarding these residues, that is, replacements of Lys94, Lys97, Thr121, Arg 123, Tyr135, and Tyr137 to Ala, decreased the activity of recombinant LbAly28 to various degrees. From these results we concluded that LbAly28 is a member of PL-14 alginate lyases. Besides the effects of above mutations, we noticed that the replacement of T121 by Ala changed the substrate preference of LbAly28. Namely, the activities toward sodium alginate and poly(MG)-block substrate increased and became comparable with the activity toward poly(M)-block substrate. This suggests that the region including T121 of LbAly28 closely relates to the recognition of poly(MG) region of alginate.

  9. Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.

    Science.gov (United States)

    Jin, Shunying; Merchant, Michael L; Ritzenthaler, Jeffrey D; McLeish, Kenneth R; Lederer, Eleanor D; Torres-Gonzalez, Edilson; Fraig, Mostafa; Barati, Michelle T; Lentsch, Alex B; Roman, Jesse; Klein, Jon B; Rane, Madhavi J

    2015-01-01

    Immune-complexes play an important role in the inflammatory diseases of the lung. Neutrophil activation mediates immune-complex (IC) deposition-induced acute lung injury (ALI). Components of gamma amino butyric acid (GABA) signaling, including GABA B receptor 2 (GABABR2), GAD65/67 and the GABA transporter, are present in the lungs and in the neutrophils. However, the role of pulmonary GABABR activation in the context of neutrophil-mediated ALI has not been determined. Thus, the objective of the current study was to determine whether administration of a GABABR agonist, baclofen would ameliorate or exacerbate ALI. We hypothesized that baclofen would regulate IC-induced ALI by preserving pulmonary GABABR expression. Rats were subjected to sham injury or IC-induced ALI and two hours later rats were treated intratracheally with saline or 1 mg/kg baclofen for 2 additional hours and sacrificed. ALI was assessed by vascular leakage, histology, TUNEL, and lung caspase-3 cleavage. ALI increased total protein, tumor necrosis factor α (TNF-α and interleukin-1 receptor associated protein (IL-1R AcP), in the bronchoalveolar lavage fluid (BALF). Moreover, ALI decreased lung GABABR2 expression, increased phospho-p38 MAPK, promoted IκB degradation and increased neutrophil influx in the lung. Administration of baclofen, after initiation of ALI, restored GABABR expression, which was inhibited in the presence of a GABABR antagonist, CGP52432. Baclofen administration activated pulmonary phospho-ERK and inhibited p38 MAPK phosphorylation and IκB degradation. Additionally, baclofen significantly inhibited pro-inflammatory TNF-α and IL-1βAcP release and promoted BAL neutrophil apoptosis. Protective effects of baclofen treatment on ALI were possibly mediated by inhibition of TNF-α- and IL-1β-mediated inflammatory signaling. Interestingly, GABABR2 expression was regulated in the type II pneumocytes in lung tissue sections from lung injured patients, further suggesting a

  10. The pros and cons of endovascular and open surgical treatments for patients with acute limb ischemia.

    Science.gov (United States)

    Branco, B C; Montero-Baker, M F; Mills, J L

    2015-06-01

    The present review addresses the pros and cons of the current, wide variety of therapeutic options available for the treatment of acute limb ischemia (ALI). Despite five prospective randomized controlled trials comparing catheter directed thrombolysis and open surgical revascularization, no single treatment strategy can yet be considered optimal for patients with ALI. This report includes 20 years of published data to evaluate the efficacy and safety profile of thrombolytic agents and adjunctive endovascular techniques when compared to open surgical revascularization.

  11. Ma Biao,Vice Chairman of the Chinese People’s Political Consultative Conference and Vice President of the Chinese People’s Association for Peace and Disarmament,leads a delegation on a good-will visit to Azerbaijan and Turkey during 3rd-10

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>Ma Biao and his party meeting with H.E.Mr.Ali Ahmadov,Deputy Prime Minister of Azerbaijan.Ma Biao and his party visiting the Center for Strategic Studies under the President of Azerbaijan.Ma Biao warmly shaking hands with Deputy Prime Minister Ali Ahmadov.Ma Biao and his party attending the seminar entitled"The Silk Road:Communication,Cooperation and Win-Win"co-hosted by the CPAPD and Marmara Group Foundation in Istanbul.

  12. Evaluation of Three Commercial Backpack Sprayers with Aqualuer (registered trademark) 20-20 Against Caged Adult Aedes aegypti

    Science.gov (United States)

    2016-03-11

    Sprayers with Aqualuer® 20–20 Against Caged Adult Aedes Aegypti Author(s): Derrick Conover, Ali Fulcher, Michael L. Smith, Muhammad Farooq, Marcia K...AEDES AEGYPTI DERRICK CONOVER,1 ALI FULCHER,1 MICHAEL L. SMITH,1 MUHAMMAD FAROOQ,2 MARCIA K. GAINES1 AND RUI-DE XUE1,3 ABSTRACT. Three commercially...adult Aedes aegypti in semifield trials in northeastern Florida. Two battery-powered sprayers, Birchmeier and Hudson, were compared with the standard

  13. Effect of breastfeeding piperine on the learning of offspring mice: interaction with caffeine and diazepam

    OpenAIRE

    Moghadamnia, Ali Akbar

    2010-01-01

    Ali Akbar Moghadamnia1,2, Vahid Zangoori2, Seyed Sadegh Zargar-Nattaj2, Pooya Tayebi2, Yasaman Moghadamnia3, Seyed Gholam Ali Jorsaraei41Cellular and Molecular Biology Research Center, Department of Pharmacology, 2Department of Pharmacology, 3Department of Physics, Alzzahra University, Babol University of Medical Sciences, Tehran, Iran; 4Department of Anatomical Iran; Sciences and Embryology, Tehran, IranAbstract: Piperine, the main alkaloid of black pepper (Piper nigrum), has been suggested ...

  14. International Symposium on Halide Glasses (2nd) (Extended Abstracts).

    Science.gov (United States)

    1983-08-05

    method in which Pyrex 7740 is the standard material. These results will be compared with our earlier results on a fluorozirconate glass ( ZBLAN glass ...AliS 215 INTERNATIONAL SYMPOSIUM ON HALIDE GLASSES 12ND) 1/1 (EXTENDED ABSTRACTS) (U) RENSSELAER POLY’TECHNIC INST TROY NY DEPT OF MATERIALS ENGINEE...Classification) Second International Symposium on Halide Glasses (Extended Abstracts) (U) 12. PERSONAL AUTHOR(S) Cornelius T. Moynihan Chairman 13a

  15. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.

    Directory of Open Access Journals (Sweden)

    Jason D Christie

    Full Text Available Acute Lung Injury (ALI is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA approach to identify putative risk variants for ALI. Genome wide genotyping was performed using the Illumina Human Quad 610 BeadChip. We performed a two-stage GWA study followed by a third stage of functional characterization. In the discovery phase (Phase 1, we compared 600 European American trauma-associated ALI cases with 2266 European American population-based controls. We carried forward the top 1% of single nucleotide polymorphisms (SNPs at p<0.01 to a replication phase (Phase 2 comprised of a nested case-control design sample of 212 trauma-associated ALI cases and 283 at-risk trauma non-ALI controls from ongoing cohort studies. SNPs that replicated at the 0.05 level in Phase 2 were subject to functional validation (Phase 3 using expression quantitative trait loci (eQTL analyses in stimulated B-lymphoblastoid cell lines (B-LCL in family trios. 159 SNPs from the discovery phase replicated in Phase 2, including loci with prior evidence for a role in ALI pathogenesis. Functional evaluation of these replicated SNPs revealed rs471931 on 11q13.3 to exert a cis-regulatory effect on mRNA expression in the PPFIA1 gene (p = 0.0021. PPFIA1 encodes liprin alpha, a protein involved in cell adhesion, integrin expression, and cell-matrix interactions. This study supports the feasibility of future multi-center GWA investigations of ALI risk, and identifies PPFIA1 as a potential functional candidate ALI risk gene for future research.

  16. Mechanical ventilation strategies for intensive care unit patients without acute lung injury or acute respiratory distress syndrome: a systematic review and network meta-analysis

    OpenAIRE

    Guo, Lei; Wang, Weiwei; Zhao, Nana; Guo, Libo; Chi, Chunjie; Hou, Wei; Wu, Anqi; Tong, Hongshuang; Wang, Yue; Wang, Changsong; Li, Enyou

    2016-01-01

    Background It has been shown that the application of a lung-protective mechanical ventilation strategy can improve the prognosis of patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). However, the optimal mechanical ventilation strategy for intensive care unit (ICU) patients without ALI or ARDS is uncertain. Therefore, we performed a network meta-analysis to identify the optimal mechanical ventilation strategy for these patients. Methods We searched the Cochra...

  17. Radiological anatomy of the C7 vertebra: Clinical implications in spine surgery.

    OpenAIRE

    Fatih Keskin; Fatih Erdi; Alaaddin Nayman; Ozan Babaoglu; Kalkan Erdal; Ali Fahir Ozer

    2015-01-01

    Radiological anatomy of the C7 vertebra: Clinical implications in spine surgery Fatih Keskin, Fatih Erdi, Alaaddin Nayman, Ozan Babaoglu, Kalkan Erdal and Ali Ozer Journal of Craniovertebral Junction and Spine. 6.1 (January-March 2015): p30. Copyright: COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd. http://www.jcvjs.com/ Full Text: Byline: Fatih. Keskin, Fatih. Erdi, Alaaddin. Nayman, Ozan. Babaoglu, Kalkan. Erdal, Ali. Ozer Context: This study was designed to understand and define th...

  18. Simple facet joint repair with dynamic pedicular system: Technical note and case series

    OpenAIRE

    Ali Fahir Ozer; Tuncer Suzer; Mehdi Sasani; Tunc Oktenoglu; Phillip Cezayirli; Hosein Jafari Marandi; Deniz Ufuk Erbulut

    2015-01-01

    Simple facet joint repair with dynamic pedicular system: Technical note and case series Ali Ozer, Tuncer Suzer, Mehdi Sasani, Tunc Oktenoglu, Phillip Cezayirli and Hosein Marandi Journal of Craniovertebral Junction and Spine. 6.2 (April-June 2015): p65. Copyright: COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd. http://www.jcvjs.com/ Full Text: Byline: Ali. Ozer, Tuncer. Suzer, Mehdi. Sasani, Tunc. Oktenoglu, Phillip. Cezayirli, Hosein. Marandi, Deniz. Erbulut Purpose: Facet joints are...

  19. Advances in Clinical Stratergies of Lung Protective Ventilation%肺保护性通气策略临床应用进展

    Institute of Scientific and Technical Information of China (English)

    郑康; 郑亚安

    2011-01-01

    In patients with ALI/ARDS, mechanical ventilation with lung protective ventilation strategies results in decreased mortality and enhances the number of days without ventilator use. While guidelines now strongly advise using lung protective ventilation in ALI/ARDS patients, there are presently no widely agreed - upon guidelines for the use of ventilation with lung protective ventilation strategies in patients who with non - ALI/ARDS conditions. Literatures concerning animal and clinical studies on lung protective mechanical ventilation in patients with non - ALI/ARDS conditions were searched out, and aspects including post ventilation oxygenation indices, cytokine levels, and lung histology were reviewed. The inconsistent results from different trials, however, do not definitely support the use of lung protective mechanical ventilation. Nevertheless, more prospective studies are needed to establish the optimal ventilator management strategies for patients with non - ALI/ARDS conditions.%机械通气时采取肺保护性通气策略有利于急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)患者缩短机械通气时间,降低病死率,在临床中已广泛应用.但是对于非ALI/ARDS的患者是否也采取肺保护性通气策略意见并不一致.现综述近年来的研究情况,包括机械通气后氧合指标、细胞因子水平和肺组织结构等方面的变化.目前对于肺保护性通气策略是否有利于避免非ALI/ARDS患者肺损伤的发生,研究结果并不一致,尚无明确结论.

  20. To Our Great Detriment: Ignoring What Extremists Say About Jihad

    Science.gov (United States)

    2007-07-01

    ed., trans. ‘Abdullah Yusuf ‘Ali (Beltsville: Amana Publications, 1999). Cited hereafter as Yusuf Ali. 81 Catherine Philp , “Newsweek sparks global...The Mystery of the Insurgency.” The New York Times. 15 May 2005. Accessed on LexisNexis, 15 May 2005. Black’s Law Dictionary. 6th ed. St. Paul ...2005. Peters, Rudolph. Jihad in Classical and Modern Islam: A Reader. Princeton: Markus Wiener Publishers, 1996. Philp , Catherine

  1. Pakistan’s Kashmir Policy and Strategy Since 1947

    Science.gov (United States)

    2004-03-01

    struggle was piecemeal and uncoordinated. Pakistan’s resort to military force was not a strategy that Mohammed Ali Jinnah and his All India Muslim League...Kashmir has its origins in the two-nation theory that Muhammad Ali Jinnah utilized to convince the British that a separate nation for the Muslims of...secular, civilian government suffered a major blow when Jinnah died shortly after partition . Therefore, power rapidly devolved to the institutions that

  2. Threat Recognition and Response. Volume 2,

    Science.gov (United States)

    1986-08-01

    was fundamentally opposed to both Hindu and ~ -. secular Indian nationalism. Mohammed Ali Jinnah , the leader of the Muslim League and the formost...towards the Muslim National Movement and thus towards Pakistan’s National Interests. Thus Mohammed Ali Jinnah __ 12-4 imnmediately issued a strong protest...go, when presented with the fatal personal agreement to partition , he did the obvious thing and raised his demands. The Fuhrer now insisted on a

  3. Pakistan’s First Military Coup: Why Did the First Pakistani Coup Occur and Why Does it Matter?

    Science.gov (United States)

    2012-03-01

    great founder, Mohammed Ali Jinnah , died in 1948, which not only delayed the formation of a constitution but also left the country in political chaos...the principle that Islam needed no territorial recognition. Most of them were against partition and criticized Muhammad Ali Jinnah on his efforts...Institution Press, 2004), 10. 3 Ibid. 4 Jaswant Singh, Jinnah India- Partition Independence (New Delhi: Rupa.Co, 2009), 25, 26. 2 one invader to another

  4. What Drives Pakistan’s Interest in Afghanistan?

    Science.gov (United States)

    2011-05-19

    independent Muslim nation. In 1937, Mohammed Ali Jinnah , a major political leader in the Muslim League, future Governor-General of Pakistan and...increased with substantial inter-ethnic friction to the point of nearly breaking the country apart. 25 In 1944, Ali Jinnah and Gandhi met in Bombay to...Christopher L. Budihas, United States Army, 59 pages. Due to its haphazard partition from British Colonial India and a series of internal and

  5. Impediments Involved in the Integration of Federally Administrated Tribal Areas (FATA) in the National Mainstream of Pakistan

    Science.gov (United States)

    2009-12-11

    continuation of agreements12 between tribes and the British Government by Quaid-e- Azam Muhammad Ali Jinnah .13 Since then no fundamental change in the...for the FATA remaining as part of Pakistan. ‘Muhammad Ali Jinnah ’ the first Governor General of Pakistan issued immediately orders and notifications... Partition Plan’ of India and in other word, the NWF of India including the FATA was liberated by the efforts of Muslims of India from the British rule and

  6. Islamic Fundamentalism in Pakistan. Its Characters and Prospects

    Science.gov (United States)

    1991-01-01

    For although Pakistan was founded as a Muslim homeland, it was not at all the intention of its founder, Muhammad Ali Jinnah , that the state should be...origin: "* The founder of Pakistan, Muhammad ’Ali Jinnah , was of Isma’ili background; "* Yahya Khan, former Commander in Chief of the Army, and then...itself. These Muslims could not or would not emigrate to Pakistan during partition in 1947. Their position in Indian society is ambiguous, and they

  7. Islamic Fundamentalism in South Asia

    Science.gov (United States)

    2007-08-20

    British viceroy of India, partitioned East Bengal and West Bengal, dividing Hindus and Muslims. The British reunited Bengal in 1911, taking away...Bengal like a colony. Muhammad Ali Jinnah , the Karachi born, secular lawyer, and revered founder and first leader of Pakistan, insisted in speeches in...Thousand Oaks, London: Sage Publications, 2005, p. 40. 3 In 1948, Mohammed Ali Jinnah , the secular founder of Pakistan who called for religious

  8. Mechanism for Prevention of Alcohol-Induced Liver Injury by Dietary Methyl Donors

    OpenAIRE

    Powell, Christine L.; Bradford, Blair U.; Craig, Christopher Patrick; Tsuchiya, Masato; Uehara, Takeki; O’Connell, Thomas M.; Pogribny, Igor P.; Melnyk, Stepan; Koop, Dennis R.; Bleyle, Lisa; Threadgill, David W.; Rusyn, Ivan

    2010-01-01

    Alcohol-induced liver injury (ALI) has been associated with, among other molecular changes, abnormal hepatic methionine metabolism, resulting in decreased levels of S-adenosylmethionine (SAM). Dietary methyl donor supplements such as SAM and betaine mitigate ALI in animal models; however, the mechanisms of protection remain elusive. It has been suggested that methyl donors may act via attenuation of alcohol-induced oxidative stress. We hypothesized that the protective action of methyl donors ...

  9. Activation of PPARα by Wy-14643 ameliorates systemic lipopolysaccharide-induced acute lung injury

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Seong Ho, E-mail: yoosh@snu.ac.kr [Seoul National University Hospital, Biomedical Research Institute and Institute of Forensic Medicine, Seoul National University College of Medicine, Seoul (Korea, Republic of); Abdelmegeed, Mohamed A. [Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD (United States); Song, Byoung-Joon, E-mail: bj.song@nih.gov [Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD (United States)

    2013-07-05

    Highlights: •Activation of PPARα attenuated LPS-mediated acute lung injury. •Pretreatment with Wy-14643 decreased the levels of IFN-γ and IL-6 in ALI. •Nitrosative stress and lipid peroxidation were downregulated by PPARα activation. •PPARα agonists may be potential therapeutic targets for acute lung injury. -- Abstract: Acute lung injury (ALI) is a major cause of mortality and morbidity worldwide. The activation of peroxisome proliferator-activated receptor-α (PPARα) by its ligands, which include Wy-14643, has been implicated as a potential anti-inflammatory therapy. To address the beneficial efficacy of Wy-14643 for ALI along with systemic inflammation, the in vivo role of PPARα activation was investigated in a mouse model of lipopolysaccharide (LPS)-induced ALI. Using age-matched Ppara-null and wild-type mice, we demonstrate that the activation of PPARα by Wy-14643 attenuated LPS-mediated ALI. This was evidenced histologically by the significant alleviation of inflammatory manifestations and apoptosis observed in the lung tissues of wild-type mice, but not in the corresponding Ppara-null mice. This protective effect probably resulted from the inhibition of LPS-induced increases in pro-inflammatory cytokines and nitroxidative stress levels. These results suggest that the pharmacological activation of PPARα might have a therapeutic effect on LPS-induced ALI.

  10. Disaturated-phosphatidylcholine and Surfactant protein-B turnover in human acute lung injury and in control patients

    Directory of Open Access Journals (Sweden)

    Rizzi Sabina

    2011-03-01

    Full Text Available Abstract Background Patients with Adult Respiratory Distress Syndrome (ARDS and Acute Lung Injury (ALI have low concentrations of disaturated-phosphatidylcholine and surfactant protein-B in bronchoalveolar lavage fluid. No information is available on their turnover. Objectives To analyze disaturated-phosphatidylcholine and surfactant protein-B turnover in patients with ARDS/ALI and in human adults with normal lungs (controls. Methods 2H2O as precursor of disaturated-phosphatidylcholine-palmitate and 113C-Leucine as precursor of surfactant protein-B were administered intravenously to 12 patients with ARDS/ALI and to 8 controls. Disaturated-phosphatidylcholine and surfactant protein-B were isolated from serial tracheal aspirates, and their fractional synthetic rate was derived from the 2H and 13C enrichment curves, obtained by gas chromatography mass spectrometry. Disaturated-phosphatidylcholine, surfactant protein-B, and protein concentrations in tracheal aspirates were also measured. Results 1 Surfactant protein-B turned over at faster rate than disaturated-phosphatidylcholine both in ARDS/ALI patients and in controls. 2 In patients with ARDS/ALI the fractional synthesis rate of disaturated-phosphatidylcholine was 3.1 times higher than in controls (p Conclusions 1 Disaturated-phosphatidylcholine and surfactant protein-B have a different turnover both in healthy and diseased lungs. 2 In ARDS/ALI the synthesis of these two surfactant components may be differently regulated.

  11. Effects of hypercapnia and hypercapnic acidosis on attenuation of ventilator-associated lung injury.

    Science.gov (United States)

    Ismaiel, N M; Henzler, D

    2011-07-01

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with impaired gas exchange, severe inflammation and alveolar damage including cell death. Patients with ALI or ARDS typically experience respiratory failure and thus require mechanical ventilation for support, which itself can aggravate lung injury. Recent developments in this field have revealed several therapeutic strategies that improve gas exchange, increase survival and minimize the deleterious effects of mechanical ventilation. Among those strategies is the reduction in tidal volume and allowing hypercapnia to develop during ventilation, or actively inducing hypercapnia. Here, we provide an overview of hypercapnia and the hypercapnic acidosis that typically follows, as well as the therapeutic effects of hypercapnia and acidosis in clinical studies and experimental models of ALI. Specifically, we review the effects of hypercapnia and acidosis on the attenuation of pulmonary inflammation, reduction of apoptosis in alveolar epithelial cells, improvement in sepsis-induced ALI and the therapeutic effects on other organ systems, as well as the potentially harmful effects of these strategies. The clinical implications of hypercapnia and hypercapnic acidosis are still not entirely clear. However, future research should focus on the intracellular signaling pathways that mediate ALI development, potentially focusing on the role of reactive biological species in ALI pathogenesis. Future research can also elucidate how such pathways may be targeted by hypercapnia and hypercapnic acidosis to attenuate lung injury.

  12. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.

    Science.gov (United States)

    Imai, Yumiko; Kuba, Keiji; Neely, G Greg; Yaghubian-Malhami, Rubina; Perkmann, Thomas; van Loo, Geert; Ermolaeva, Maria; Veldhuizen, Ruud; Leung, Y H Connie; Wang, Hongliang; Liu, Haolin; Sun, Yang; Pasparakis, Manolis; Kopf, Manfred; Mech, Christin; Bavari, Sina; Peiris, J S Malik; Slutsky, Arthur S; Akira, Shizuo; Hultqvist, Malin; Holmdahl, Rikard; Nicholls, John; Jiang, Chengyu; Binder, Christoph J; Penninger, Josef M

    2008-04-18

    Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI). We show that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI. The oxidized phospholipid (OxPL) OxPAPC was identified to induce lung injury and cytokine production by lung macrophages via TLR4-TRIF. We observed OxPL production in the lungs of humans and animals infected with SARS, Anthrax, or H5N1. Pulmonary challenge with an inactivated H5N1 avian influenza virus rapidly induces ALI and OxPL formation in mice. Loss of TLR4 or TRIF expression protects mice from H5N1-induced ALI. Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI.

  13. Combining different functions to describe milk, fat, and protein yield in goats using Bayesian multiple-trait random regression models.

    Science.gov (United States)

    Oliveira, H R; Silva, F F; Siqueira, O H G B D; Souza, N O; Junqueira, V S; Resende, M D V; Borquis, R R A; Rodrigues, M T

    2016-05-01

    We proposed multiple-trait random regression models (MTRRM) combining different functions to describe milk yield (MY) and fat (FP) and protein (PP) percentage in dairy goat genetic evaluation by using Bayesian inference. A total of 3,856 MY, FP, and PP test-day records, measured between 2000 and 2014, from 535 first lactations of Saanen and Alpine goats, including their cross, were used in this study. The initial analyses were performed using the following single-trait random regression models (STRRM): third- and fifth-order Legendre polynomials (Leg3 and Leg5), linear B-splines with 3 and 5 knots, the Ali and Schaeffer function (Ali), and Wilmink function. Heterogeneity of residual variances was modeled considering 3 classes. After the selection of the best STRRM to describe each trait on the basis of the deviance information criterion (DIC) and posterior model probabilities (PMP), the functions were combined to compose the MTRRM. All combined MTRRM presented lower DIC values and higher PMP, showing the superiority of these models when compared to other MTRRM based only on the same function assumed for all traits. Among the combined MTRRM, those considering Ali to describe MY and PP and Leg5 to describe FP (Ali_Leg5_Ali model) presented the best fit. From the Ali_Leg5_Ali model, heritability estimates over time for MY, FP. and PP ranged from 0.25 to 0.54, 0.27 to 0.48, and 0.35 to 0.51, respectively. Genetic correlation between MY and FP, MY and PP, and FP and PP ranged from -0.58 to 0.03, -0.46 to 0.12, and 0.37 to 0.64, respectively. We concluded that combining different functions under a MTRRM approach can be a plausible alternative for joint genetic evaluation of milk yield and milk constituents in goats.

  14. Cordyceps Militaris Alleviates Severity of Murine Acute Lung Injury Through miRNAs-Mediated CXCR2 Inhibition

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    Sheng Liu

    2015-07-01

    Full Text Available Background/Aims: Acute lung injury (ALI and acute respiratory distress syndrome (ARDS are lethal diseases in humans, and the current treatments have limited therapeutic effects. Cordyceps militaris (CM is a caterpillar-grown traditional medicinal mushroom, and has been used as a natural invigorant for longevity, endurance, and vitality in China. Recently, purified extracts from CM have been shown to have beneficial effects on various diseases including cancer. Nevertheless, a role of CM in ALI has not been examined previously. Methods: Here, we used a bleomycin-induced ALI model to study the effects of CM on the severity of ALI in mice. The levels of CXCR2, a receptor for Interleukin 8 (IL-8 in pulmonary microvascular endothelial cells, were examined in different experimental groups. The levels of microRNA (miR-1321 and miR-3188 were also examined in lung samples and in CM. Adeno-associated viruses carrying miR-1321 and miR-3188 were injected into bleomycin-treated mice for evaluation their effects on the severity of ALI. Results: CM treatment significantly alleviated the severity of bleomycin-induced ALI in mice. The increases in lung CXCR2 by bleomycin were significantly reduced by CM at protein level, but not at mRNA level. CM contained high levels of 2 miRNAs (miR-1321 and miR-3188 that target 3'-UTR of CXCR2 mRNA to inhibit its expression. Overexpression of miR-1321 and miR-3188 in mouse lung through AAV-mediated gene therapy mimicked the effects of CM. Conclusion: CM may alleviate severity of murine ALI through miRNAs-mediated CXCR2 inhibition.

  15. Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury

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    Matthay Michael A

    2011-04-01

    Full Text Available Abstract Background Multiple studies have identified single variables or composite scores that help risk stratify patients at the time of acute lung injury (ALI diagnosis. However, few studies have addressed the important question of how changes in pulmonary physiologic variables might predict mortality in patients during the subacute or chronic phases of ALI. We studied pulmonary physiologic variables, including respiratory system compliance, P/F ratio and oxygenation index, in a cohort of patients with ALI who survived more than 6 days of mechanical ventilation to see if changes in these variables were predictive of death and whether they are informative about the pathophysiology of subacute ALI. Methods Ninety-three patients with ALI who were mechanically ventilated for more than 6 days were enrolled in this prospective cohort study. Patients were enrolled at two medical centers in the US, a county hospital and a large academic center. Bivariate analyses were used to identify pulmonary physiologic predictors of death during the first 6 days of mechanical ventilation. Predictors on day 1, day 6 and the changes between day 1 and day 6 were compared in a multivariate logistic regression model. Results The overall mortality was 35%. In multivariate analysis, the PaO2/FiO2 (OR 2.09, p th day of acute lung injury. In addition, a decrease in respiratory system compliance between days 1 and days 6 (OR 2.14, p Conclusions A low respiratory system compliance on day 6 or a decrease in the respiratory system compliance between the 1st and 6th day of mechanical ventilation were associated with increased mortality in multivariate analysis of this cohort of patients with ALI. We suggest that decreased respiratory system compliance may identify a subset of patients who have persistent pulmonary edema, atelectasis or the fibroproliferative sequelae of ALI and thus are less likely to survive their hospitalization.

  16. Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment.

    Science.gov (United States)

    Garibaldi, Brian T; D'Alessio, Franco R; Mock, Jason R; Files, D Clark; Chau, Eric; Eto, Yoshiki; Drummond, M Bradley; Aggarwal, Neil R; Sidhaye, Venkataramana; King, Landon S

    2013-01-01

    Acute lung injury (ALI) causes significant morbidity and mortality. Fibroproliferation in ALI results in worse outcomes, but the mechanisms governing fibroproliferation remain poorly understood. Regulatory T cells (Tregs) are important in lung injury resolution. Their role in fibroproliferation is unknown. We sought to identify the role of Tregs in ALI fibroproliferation, using a murine model of lung injury. Wild-type (WT) and lymphocyte-deficient Rag-1(-/-) mice received intratracheal LPS. Fibroproliferation was characterized by histology and the measurement of lung collagen. Lung fibrocytes were measured by flow cytometry. To dissect the role of Tregs in fibroproliferation, Rag-1(-/-) mice received CD4(+)CD25(+) (Tregs) or CD4(+)CD25(-) Tcells (non-Tregs) at the time of LPS injury. To define the role of the chemokine (C-X-C motif) ligand 12 (CXCL12)-CXCR4 pathway in ALI fibroproliferation, Rag-1(-/-) mice were treated with the CXCR4 antagonist AMD3100 to block fibrocyte recruitment. WT and Rag-1(-/-) mice demonstrated significant collagen deposition on Day 3 after LPS. WT mice exhibited the clearance of collagen, but Rag-1(-/-) mice developed persistent fibrosis. This fibrosis was mediated by the sustained epithelial expression of CXCL12 (or stromal cell-derived factor 1 [SDF-1]) that led to increased fibrocyte recruitment. The adoptive transfer of Tregs resolved fibroproliferation by decreasing CXCL12 expression and subsequent fibrocyte recruitment. Blockade of the CXCL12-CXCR4 axis with AMD3100 also decreased lung fibrocytes and fibroproliferation. These results indicate a central role for Tregs in the resolution of ALI fibroproliferation by reducing fibrocyte recruitment along the CXCL12-CXCR4 axis. A dissection of the role of Tregs in ALI fibroproliferation may inform the design of new therapeutic tools for patients with ALI.

  17. The Arabidopsis P4-ATPase ALA3 localizes to the golgi and requires a beta-subunit to function in lipid translocation and secretory vesicle formation.

    Science.gov (United States)

    Poulsen, Lisbeth Rosager; López-Marqués, Rosa Laura; McDowell, Stephen C; Okkeri, Juha; Licht, Dirk; Schulz, Alexander; Pomorski, Thomas; Harper, Jeffrey F; Palmgren, Michael Gjedde

    2008-03-01

    Vesicle budding in eukaryotes depends on the activity of lipid translocases (P(4)-ATPases) that have been implicated in generating lipid asymmetry between the two leaflets of the membrane and in inducing membrane curvature. We show that Aminophospholipid ATPase3 (ALA3), a member of the P(4)-ATPase subfamily in Arabidopsis thaliana, localizes to the Golgi apparatus and that mutations of ALA3 result in impaired growth of roots and shoots. The growth defect is accompanied by failure of the root cap to release border cells involved in the secretion of molecules required for efficient root interaction with the environment, and ala3 mutants are devoid of the characteristic trans-Golgi proliferation of slime vesicles containing polysaccharides and enzymes for secretion. In yeast complementation experiments, ALA3 function requires interaction with members of a novel family of plant membrane-bound proteins, ALIS1 to ALIS5 (for ALA-Interacting Subunit), and in this host ALA3 and ALIS1 show strong affinity for each other. In planta, ALIS1, like ALA3, localizes to Golgi-like structures and is expressed in root peripheral columella cells. We propose that the ALIS1 protein is a beta-subunit of ALA3 and that this protein complex forms an important part of the Golgi machinery required for secretory processes during plant development.

  18. Regional pulmonary inflammation in an endotoxemic ovine acute lung injury model.

    Science.gov (United States)

    Fernandez-Bustamante, A; Easley, R B; Fuld, M; Mulreany, D; Chon, D; Lewis, J F; Simon, B A

    2012-08-15

    The regional distribution of inflammation during acute lung injury (ALI) is not well known. In an ovine ALI model we studied regional alveolar inflammation, surfactant composition, and CT-derived regional specific volume change (sVol) and specific compliance (sC). 18 ventilated adult sheep received IV lipopolysaccharide (LPS) until severe ALI was achieved. Blood and bronchoalveolar lavage (BAL) samples from apical and basal lung regions were obtained at baseline and injury time points, for analysis of cytokines (IL-6, IL-1β), BAL protein and surfactant composition. Whole lung CT images were obtained in 4 additional sheep. BAL protein and IL-1β were significantly higher in injured apical vs. basal regions. No significant regional surfactant composition changes were observed. Baseline sVol and sC were lower in apex vs. base; ALI enhanced this cranio-caudal difference, reaching statistical significance only for sC. This study suggests that apical lung regions show greater inflammation than basal ones during IV LPS-induced ALI which may relate to differences in regional mechanical events.

  19. Asiaticoside attenuates lipopolysaccharide-induced acute lung injury via down-regulation of NF-κB signaling pathway.

    Science.gov (United States)

    Qiu, Jiaming; Yu, Lijun; Zhang, Xingxing; Wu, Qianchao; Wang, Di; Wang, Xiuzhi; Xia, Cheng; Feng, Haihua

    2015-05-01

    Asiaticoside (AS), a triterpene glycoside isolated from Centella asiatica, has been shown to possess potent anti-inflammatory activity. However, the detailed molecular mechanisms of AS on lipopolysaccharide (LPS)-induced acute lung injury (ALI) model in mice are scanty. The purpose of this study was to evaluate the effect of AS on LPS-induced mouse ALI via down-regulation of NF-κB signaling pathway. We investigated the efficacy of AS on cytokine levels induced by LPS in bronchoalveolar lavage fluid (BALF) and RAW 264.7 cells. The production of cytokine (TNF-α and IL-6) was measured by enzyme-linked immunosorbent assay (ELISA). The lung wet-to-dry weight ratios were measured in LPS-challenged mice, and lung histopathologic changes observed via paraffin section were assessed. To further study the mechanism of AS protective effects on ALI, the activation of NF-κB p65 subunit and the degradation of IκBα were tested by western blot assay. We found that AS treatment at 15, 30 or 45mg/kg dose-dependently attenuated LPS-induced pulmonary inflammation by reducing inflammatory infiltration, histopathological changes, descended cytokine production, and pulmonary edema initiated by LPS. Furthermore, our results suggested that AS suppressed inflammatory responses in LPS-induced ALI through inhibition of the phosphorylation of NF-κB p65 subunit and the degradation of its inhibitor IκBα, and might be a new preventive agent of ALI in the clinical setting.

  20. Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation.

    Science.gov (United States)

    Rossaint, Jan; Herter, Jan M; Van Aken, Hugo; Napirei, Markus; Döring, Yvonne; Weber, Christian; Soehnlein, Oliver; Zarbock, Alexander

    2014-04-17

    There is emerging evidence that neutrophil extracellular traps (NETs) play important roles in inflammatory processes. Here we report that neutrophils have to be simultaneously activated by integrin-mediated outside-in- and G-protein-coupled receptor (GPCR) signaling to induce NET formation in acute lung injury (ALI), which is associated with a high mortality rate in critically ill patients. NETs consist of decondensed chromatin decorated with granular and cytosolic proteins and they can trap extracellular pathogens. The prerequisite for NET formation is the activation of neutrophils and the release of their DNA. In a neutrophil- and platelet-dependent mouse model of ventilator-induced lung injury (VILI), NETs were found in the lung microvasculature, and circulating NET components increased in the plasma. In this model, blocking integrin-mediated outside-in or either GPCR-signaling or heteromerization of platelet chemokines decreased NET formation and lung injury. Targeting NET components by DNAse1 application or neutrophil elastase-deficient mice protected mice from ALI, whereas DNase1(-/-)/Trap1(m/m) mice had an aggravated ALI, suggesting that NETs directly influence the severity of ALI. These data suggest that NETs form in the lungs during VILI, contribute to the disease process, and thus may be a promising new direction for the treatment of ALI.

  1. Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2

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    Kyun Ha Kim

    2013-01-01

    Full Text Available Acute lung injury (ALI is an inflammatory disease with high mortality, but therapeutics against it is unavailable. Recently, we elaborated a formula, named Chung-pae (CP, that comprises four ethnic herbs commonly prescribed against various respiratory diseases in Asian traditional medicine. CP is being administered in aerosol to relieve various respiratory symptoms of patients in our clinic. Here, we sought to examine whether CP has a therapeutic effect on ALI and to uncover the mechanism behind it. Reporter assays show that CP suppressed the transcriptional activity of proinflammatory NF-κB and activated that of anti-inflammatory Nrf2. Similarly, CP suppressed the expression of NF-κB dependent, proinflammatory cytokines and induced that of Nrf2 dependent genes in RAW 264.7. An aerosol intratracheal administration of CP effectively reduced neutrophilic infiltration and the expression of pro-inflammatory cytokines, hallmarks of ALI, in the lungs of mice that received a prior intraperitoneal injection of lipopolysaccharide. The intratracheal CP administration concomitantly enhanced the expression of Nrf2 dependent genes in the lung. Therefore, our results evidenced a therapeutic effect of CP on ALI, in which differential regulation of the two key inflammatory factors, NF-κB and Nrf2, was involved. We propose that CP can be a new therapeutic formula against ALI.

  2. Antiplatelet antibody may cause delayed transfusion-related acute lung injury

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    Torii Y

    2011-09-01

    Full Text Available Yoshitaro Torii1, Toshiki Shimizu1, Takashi Yokoi1, Hiroyuki Sugimoto1, Yuichi Katashiba1, Ryotaro Ozasa1, Shinya Fujita1, Yasushi Adachi2, Masahiko Maki3, Shosaku Nomura11The First Department of Internal Medicine, Kansai Medical University, Osaka, 2Department of Clinical Pathology, Toyooka Hospital, Hyogo, 3First Department of Pathology, Kansai Medical University, Osaka, JapanAbstract: A 61-year-old woman with lung cancer developed delayed transfusion-related acute lung injury (TRALI syndrome after transfusion of plasma- and leukoreduced red blood cells (RBCs for gastrointestinal bleeding due to intestinal metastasis. Acute lung injury (ALI recurred 31 days after the first ALI episode. Both ALI episodes occurred 48 hours after transfusion. Laboratory examinations revealed the presence of various antileukocyte antibodies including antiplatelet antibody in the recipient's serum but not in the donors' serum. The authors speculate that antiplatelet antibodies can have an inhibitory effect in the recipient, which can modulate the bona fide procedure of ALI and lead to a delay in the onset of ALI. This case illustrates the crucial role of a recipient's platelets in the development of TRALI.Keywords: delayed TRALI syndrome, recurrence, anti-platelet antibody

  3. Proteomic Analysis of Lung Tissue in a Rat Acute Lung Injury Model: Identification of PRDX1 as a Promoter of Inflammation

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    Dongdong Liu

    2014-01-01

    Full Text Available Acute respiratory distress syndrome (ARDS remains a high morbidity and mortality disease entity in critically ill patients, despite decades of numerous investigations into its pathogenesis. To obtain global protein expression changes in acute lung injury (ALI lung tissues, we employed a high-throughput proteomics method to identify key components which may be involved in the pathogenesis of ALI. In the present study, we analyzed lung tissue proteomes of Pseudomonas aeruginosa-induced ALI rats and identified eighteen proteins whose expression levels changed more than twofold as compared to normal controls. In particular, we found that PRDX1 expression in culture medium was elevated by a lipopolysaccharide (LPS challenge in airway epithelial cells in vitro. Furthermore, overexpression of PRDX1 increased the expression of proinflammatory cytokines interleukin-6 (IL-6, interleukin-8 (IL-8, and tumor necrosis factor-α (TNF-α, whereas knockdown of PRDX1 led to downregulated expression of cytokines induced by LPS. In conclusion, our findings provide a global alteration in the proteome of lung tissues in the ALI rat model and indicate that PRDX1 may play a critical role in the pathogenesis of ARDS by promoting inflammation and represent a novel strategy for the development of new therapies against ALI.

  4. Interference-free spectrofluorometric quantification of aristolochic acid I and aristololactam I in five Chinese herbal medicines using chemical derivatization enhancement and second-order calibration methods

    Science.gov (United States)

    Hu, Yong; Wu, Hai-Long; Yin, Xiao-Li; Gu, Hui-Wen; Xiao, Rong; Wang, Li; Fang, Huan; Yu, Ru-Qin

    2017-03-01

    A rapid interference-free spectrofluorometric method combined with the excitation-emission matrix fluorescence and the second-order calibration methods based on the alternating penalty trilinear decomposition (APTLD) and the self-weighted alternating trilinear decomposition (SWATLD) algorithms, was proposed for the simultaneous determination of nephrotoxic aristolochic acid I (AA-I) and aristololactam I (AL-I) in five Chinese herbal medicines. The method was based on a chemical derivatization that converts the non-fluorescent AA-I to high-fluorescent AL-I, achieving a high sensitive and simultaneous quantification of the analytes. The variables of the derivatization reaction that conducted by using zinc powder in acetose methanol aqueous solution, were studied and optimized for best quantification results of AA-I and AL-I. The satisfactory results of AA-I and AL-I for the spiked recovery assay were achieved with average recoveries in the range of 100.4-103.8% and RMSEPs green alternative for the quantification of AA-I and AL-I in complex herbal medicine matrices without any prior separations and clear-up processes.

  5. Effects of SDF-1/CXCR4 on Acute Lung Injury Induced by Cardiopulmonary Bypass.

    Science.gov (United States)

    Shi, Hai; Lu, Rujian; Wang, Shuo; Chen, Honglin; Wang, Fei; Liu, Kun

    2017-03-11

    Acute lung injury (ALI) is one of the most important complications after cardiopulmonary bypass (CPB) and the complex pathophysiology remains to be resolved incomplete. SDF-1/CXCR4 chemokine axis can chemotactically accumulate inflammatory cell to local tissue and regulate the release of inflammatory factors, and SDF-1 has a strong chemotaxis effect on neutrophils with CXCR4. Since CPB animal model was difficult to establish, there was still no report about the effect of SDF-1/CXCR4 on neutrophil chemotaxis in ALI after CPB. Here, a stable CPB rat model was constructed to clarify the role of SDF-1/CXCR4 axis in the CPB-induced ALI. Real-time quantitative PCR (RT-qPCR), Western blot analysis, and enzyme-linked immunosorbent assay (ELISA) were used to detect the changes of SDF-1 and CXCR4 in lung tissues, blood, bronchoalveolar lavage (BALF), and/or isolated neutrophils. SDF-1/CXCR4 was increased after CPB, both of that were increased in blood; CXCR4 was increased in neutrophils; SDF-1/CXCR4 was also increased in BALF of CPB model. Results indicated that SDF-1/CXCR4 axis played a key role in the process of early ALI after CPB, also showed that lung injury was significantly reduce after blocking SDF-1/CXCR4 axis, suggest that CXCR4 might be a new target for ALI treatment.

  6. Positive Fluid Balance Is Associated with Higher Mortality and Prolonged Mechanical Ventilation in Pediatric Patients with Acute Lung Injury

    Directory of Open Access Journals (Sweden)

    Heidi R. Flori

    2011-01-01

    Full Text Available Introduction. We analyzed a database of 320 pediatric patients with acute lung injury (ALI, to test the hypothesis that positive fluid balance is associated with worse clinical outcomes in children with ALI. Methods. This is a post-hoc analysis of previously collected data. Cumulative fluid balance was analyzed in ml per kilogram per day for the first 72 hours after ALI while in the PICU. The primary outcome was mortality; the secondary outcome was ventilator-free days. Results. Positive fluid balance (in increments of 10 mL/kg/24 h was associated with a significant increase in both mortality and prolonged duration of mechanical ventilation, independent of the presence of multiple organ system failure and the extent of oxygenation defect. These relationships remained unchanged when the subgroup of patients with septic shock (n=39 were excluded. Conclusions. Persistently positive fluid balance may be deleterious to pediatric patients with ALI. A confirmatory, prospective randomized controlled trial of fluid management in pediatric patients with ALI is warranted.

  7. Leptin attenuates lipopolysaccharide or oleic acid-induced acute lung injury in mice.

    Science.gov (United States)

    Dong, Hai-Ying; Xu, Min; Ji, Zhen-Yu; Wang, Yan-Xia; Dong, Ming-Qing; Liu, Man-Ling; Xu, Dun-Quan; Zhao, Peng-Tao; Liu, Yi; Luo, Ying; Niu, Wen; Zhang, Bo; Ye, Jing; Li, Zhi-Chao

    2013-12-01

    Leptin is reported to be involved in acute lung injury (ALI). However, the role and underlying mechanisms of leptin in ALI remain unclear. The aim of this study was to determine whether leptin deficiency promoted the development of ALI. LPS or oleic acid (OA) were administered to wild-type and leptin deficient (ob/ob) mice to induce ALI. Leptin level, survival rate, and lung injury were examined. Results showed that leptin levels were predominantly increased in the lung, but also in the heart, liver, kidney, and adipose tissue after LPS adminiatration. Compared with wild-type mice, LPS- or OA-induced lung injury was worse and the survival rate was lower in ob/ob mice. Moreover, leptin deficiency promoted the release of proinflammatory cytokines. Exogenous administration of leptin reduced lethality in ob/ob mice and ameliorated lung injury partly through inhibiting the activation of NF-κB, p38, and ERK pathways. These results indicated that leptin deficiency contributed to the development of lung injury by enhancing inflammatory response, and a high level of leptin improved survival and protected against ALI.

  8. Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia.

    Science.gov (United States)

    Han, Junyan; Ma, Deshun; Zhang, Miao; Yang, Xuelian; Tan, Dehong

    2015-01-01

    The effect of betanin on a rat paraquat-induced acute lung injury (ALI) model was investigated. Paraquat was injected intraperitoneally at a single dose of 20 mg/kg body weight, and betanin (25 and 100 mg/kg/d) was orally administered 3 days before and 2 days after paraquat administration. Rats were sacrificed 24 hours after the last betanin dosage, and lung tissue and bronchoalveolar lavage fluid (BALF) were collected. In rats treated only with paraquat, extensive lung injury characteristic of ALI was observed, including histological changes, elevation of lung : body weight ratio, increased lung permeability, increased lung neutrophilia infiltration, increased malondialdehyde (MDA) and myeloperoxidase (MPO) activity, reduced superoxide dismutase (SOD) activity, reduced claudin-4 and zonula occluden-1 protein levels, increased BALF interleukin (IL-1) and tumor necrosis factor (TNF)-α levels, reduced BALF IL-10 levels, and increased lung nuclear factor kappa (NF-κB) activity. In rats treated with betanin, paraquat-induced ALI was attenuated in a dose-dependent manner. In conclusion, our results indicate that betanin attenuates paraquat-induced ALI possibly via antioxidant and anti-inflammatory mechanisms. Thus, the potential for using betanin as an auxilliary therapy for ALI should be explored further.

  9. Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome.

    Science.gov (United States)

    Wang, Shuang; Zhao, Jijun; Wang, Hongyue; Liang, Yingjie; Yang, Niansheng; Huang, Yuefang

    2015-07-01

    NLRP3 inflammasome is engaged in the inflammatory response during acute lung injury (ALI). Purinergic receptor P2X7 has been reported to be upstream of NLRP3 activation. However, the therapeutic implication of P2X7 in ALI remains to be explored. The present study used lipopolysaccharide (LPS)-induced mouse model to investigate the therapeutic potential of P2X7 blockage in ALI. Our results showed that P2X7/NLRP3 inflammasome pathway was significantly upregulated in the lungs of ALI mice as compared with control mice. P2X7 antagonist A438079 suppressed NLRP3/ASC/caspase 1 activation, production of IL-1β, IL-17A and IFN-γ and neutrophil infiltration but not the production of IL-10, resulting in a significant amelioration of lung injury. Moreover, blockage of P2X7 significantly inhibited NLRP3 inflammasome activation and IL-1β production in bone marrow derived macrophages. Similar results were obtained using another P2X7 inhibitor brilliant blue G (BBG) in vivo. Thus, pharmacological blockage of P2X7/NLRP3 pathway can be considered as a potential therapeutic strategy in patients with ALI.

  10. Variations in the lithium abundances of turn off stars in the globular cluster 47 Tuc

    CERN Document Server

    Bonifacio, Piercarlo; Molaro, Paolo; Carretta, Eugenio; François, Patrick; Gratton, Raffaele G; James, Gael; Sbordone, Luca; Spite, François; Zoccali, Manuela

    2007-01-01

    aims: Our aim is to determine Li abundances in TO stars of the Globular Cluster 47 Tuc and test theories about Li variations among TO stars. method: We make use of high resolution (R~ 43000), high signal-to-noise ratio (S/N=50--70) spectra of 4 turn off (TO) stars obtained with the UVES spectrograph at the 8.2m VLT Kueyen telescope. results: The four stars observed, span the range 1.6<~A(Li)} <~ 2.14, providing a mean A(Li) = 1.84 with a standard deviation of 0.25 dex. When coupled with data of other two TO stars of the cluster, available in the literature, the full range in Li abundances observed in this cluster is 1.6<~A(Li)<~ 2.3. The variation in A(Li) is at least 0.6 dex (0.7 dex considering also the data available in the literature) and the scatter is six times larger than what expected from the observational error. We claim that these variations are real. A(Li) seems to be anti-correlated with A(Na) exactly as observed in NGC 6752. No systematic error in our analysis could produce such an a...

  11. Endovascular management of acute limb ischemia.

    Science.gov (United States)

    Peeters, P; Verbist, J; Keirse, K; Deloose, K; Bosiers, M

    2010-06-01

    Acute limb ischemia (ALI) refers to a rapid worsening of limb perfusion resulting in rest pain, ischemic ulcers or gangrene. With an estimated incidence of 140 million/year, ALI is serious limb-threatening and life-threatening medical emergency demanding prompt action. Three prospective, randomized clinical trials provide data on trombolytic therapy versus surgical intervention in patients with acute lower extremity ischemia. Although they did not give us the final answer, satisfactory results are reported for percutaneous thrombolysis compared with surgery. Moreover, they suggest an important advantage of thrombolysis in acute bypass graft occlusions. Therefore, we believe thrombolytic therapy should be a part of the vascular surgeon's armamentarium to safely and successfully treat ALI patients.

  12. Acute lung injury induces cardiovascular dysfunction

    DEFF Research Database (Denmark)

    Suda, Koichi; Tsuruta, Masashi; Eom, Jihyoun;

    2011-01-01

    Acute lung injury (ALI) is associated with systemic inflammation and cardiovascular dysfunction. IL-6 is a biomarker of this systemic response and a predictor of cardiovascular events, but its possible causal role is uncertain. Inhaled corticosteroids and long-acting β2 agonists (ICS/LABA) down......-regulate the systemic expression of IL-6, but whether they can ameliorate the cardiovascular dysfunction related to ALI is uncertain. We sought to determine whether IL-6 contributes to the cardiovascular dysfunction related to ALI, and whether budesonide/formoterol ameliorates this process. Wild-type mice were...... these impairments (vasodilatory responses to acetylcholine, P = 0.005; cardiac output, P = 0.025). Pretreatment with the combination of budesonide and formoterol, but not either alone, ameliorated the vasodilatory responses to acetylcholine (P = 0.018) and cardiac output (P drugs also attenuated...

  13. Identifying Young Kepler Planet Host Stars from Keck-HIRES Spectra of Lithium

    Science.gov (United States)

    Berger, Travis Allen; Howard, Andrew; Boesgaard, Ann M.

    2017-01-01

    The lithium doublet at 6708 A provides an age diagnostic for FGK stars. We measured the abundance of lithium in 1149 stars with detected transiting planets from the Kepler Mission using high resolution spectroscopy. Our catalog of lithium measurements from this sample have a range of abundance from A(Li) = 3.13 +/- 0.05 to a lower limit of -0.79. For a magnitude-limited sample that comprises 930 of the 1149 stars, our Keck-HIRES spectra have a median S/N = 45 per pixel at spectral resolution R = 55,000. We identify 79 young stars that have A(Li) values greater than the Hyades at their respective effective temperatures; these stars are younger than ~650 Myr old, the approximate age of the Hyades. We then compare the distribution of A(Li) with planet size, disposition, multiplicity, orbital period, and insolation flux.

  14. Oferta ir akceptas vartojimo sutartyse

    OpenAIRE

    Ežerskytė, Ramunė

    2011-01-01

    Sutarčiai sudaryti paprastai reikia, kad viena šalis pasiūlytų sudaryti sutartį (oferta), o kita šalis sutiktų su pasiūlymu (akceptas). Sutarčių įvairovėje išskiriamos vartojimo sutartys, kurios dėl silpnesnės šalies apsaugos principo įgyvendinimo pasižymi tam tikrais ypatumais. Vartojimo sutarčių sudarymas pateikiant ofertą ir akceptą yra šio magistro baigiamojo darbo objektas. Magistro baigiamąjį darbą sudaro trys dalys. Pirmojoje darbo dalyje analizuojama vartojimo sutarties sąvoka ir spec...

  15. Analysis of regional compliance in a porcine model of acute lung injury.

    Science.gov (United States)

    Czaplik, Michael; Biener, Ingeborg; Dembinski, Rolf; Pelosi, Paolo; Soodt, Thomas; Schroeder, Wolfgang; Leonhardt, Steffen; Marx, Gernot; Rossaint, Rolf; Bickenbach, Johannes

    2012-10-15

    Lung protective ventilation in acute lung injury (ALI) focuses on using low tidal volumes and adequate levels of positive end-expiratory pressure (PEEP). Identifying optimal pressure is difficult because pressure-volume (PV) relations differ regionally. Precise analysis demands local measurements of pressures and related alveolar morphologies. In a porcine model of surfactant depletion (n=24), we combined measuring static pressures with endoscopic microscopy and electrical impedance tomography (EIT) to examine regional PV loops and morphologic heterogeneities between healthy (control group; CON) and ALI lungs ventilated with low (LVT) or high tidal volumes (HVT). Quantification included indices for microscopy (Volume Air Index (VAI), Heterogeneity and Circularity Index), EIT analysis and calculation of regional compliances due to generated PV loops. We found that: (1) VAI decreased in lower lobe after ALI, (2) electrical impedance decreased in dorsal regions and (3) PV loops differed regionally. Further studies should prove the potentials of these techniques on individual respiratory settings and clinical outcome.

  16. Rosiglitazone dampens pulmonary inflammation in a porcine model of acute lung injury.

    Science.gov (United States)

    Mirakaj, Valbona; Mutz, Christian; Vagts, Dierk; Henes, Janek; Haeberle, Helene A; Husung, Susanne; König, Tony; Nöldge-Schomburg, Gabriele; Rosenberger, Peter

    2014-08-01

    The hallmarks of acute lung injury (ALI) are the compromised alveolar-capillary barrier and the extravasation of leukocytes into the alveolar space. Given the fact that the peroxisome proliferator-activated receptor-γ agonist rosiglitazone holds significant anti-inflammatory properties, we aimed to evaluate whether rosiglitazone could dampen these hallmarks of local pulmonary inflammation in a porcine model of lung injury. For this purpose, we used a model of lipopolysaccharide (LPS, 50 μg/kg)-induced ALI. One hundred twenty minutes following the infusion of LPS, we started the exposure to rosiglitazone through inhalation or infusion. We found that intravenous rosiglitazone significantly controlled local pulmonary inflammation as determined through the expression of cytokines within the alveolar compartment. Furthermore, we found a significant reduction of the protein concentration and neutrophil activity within the alveolar space. In summary, we therefore conclude that the treatment with rosiglitazone might dampen local pulmonary inflammation during the initial stages of ALI.

  17. [Advances in the study of the relationship between autophagy and sepsis-induced lung injury].

    Science.gov (United States)

    Wang, Xingtong; Li, Hengyu; Xia, Zhaofan

    2014-08-01

    Sepsis is one of the most common pathogenetic causes of acute lung injury (ALI), and at present there is still a lack of effective targeted techniques and methods for its prevention and treatment. Autophagy is a homeostatic mecha- nism common to all eukaryotic cells, including adaption to environment, defense against invasion of pathogens, and maintenance of cellular homeostasis. Autophagy is also involved in a variety of lung-related diseases. In septic lung injury, autophagy not only serves to dissipate dysfunctional organelles, but also inhibits the release of inflammatory cytokines. This review aims at eliciting the role of autophagy in sepsis-induced ALI and further exploring the potential targets of autophagy in inhibiting inflammation, in an effort to provide a new perspective for clinical treatment of sepsis-induced ALI.

  18. A New Method for Generating Hydrogen from Water

    Institute of Scientific and Technical Information of China (English)

    MENG Qing-Bo; LI Ke-Xin; LI Hong; FAN Yu-Zun; YU Zhe-Xun; LI Dong-Mei; LUO Yan-Hong; CHEN Li-Quan

    2008-01-01

    A new method for generating hydrogen by the reaction of A1 powder with water using iodine as additive is developed. 12 can penetrate through the surface oxide layer on atuminium to form AlI3. High solubility of AlI3 in water is benefited to activate Al surface. It is found that the production of hydrogen becomes significant above 60℃ and obeys a logarithm rule. The pH value varies from 5 to 3 then back to 4.5 during the reaction,which is determined mainly by the kinetics of hydration reaction of AlI3 and the reaction of Al and HI produced spontaneously.

  19. Automobilių prekybos rinkos formavimosi ypatumai Lietuvoje

    OpenAIRE

    2010-01-01

    SANTRAUKA AUTOMOBILIŲ PREKYBOS RINKOS FORMAVIMOSI YPATUMAI LIETUVOJE Lietuva nepriklausomybės laikotarpiu išgyveno tikrai nemažų permainų laikotarpį. Šios permainos neaplenkė ir automobilizacijos lygio ir sudėties pokyčių šalyje. Atgavus nepriklausomybę, mūsų šalis tapo naudotų automobilių srautų kryžkelė. Tam, visų pirma, labiausiai pasitarnavo mūsų šalies palanki geopolitinė padėtis. Prekyba dėvėtais automobiliais tapo savotiška mūsų šalies vizitine kortele, o Lietuvos automobilių turgus ži...

  20. Acquired lobar emphysema in a case of interstitial chronic lung disease. Surgical implications and review of the literature

    Directory of Open Access Journals (Sweden)

    Sancho Hernández Rogelio

    2014-07-01

    Full Text Available Acquired lobar interstitial emphysema (ALIE, initially described in infants with bronchopulmonary dysplasia is now known to occur in other conditions such as a secondary post-traumatic or inflammatory injury as in patients requiring ventilatory sup- port with chronic lung disease. The ALIE leads to progressive deterioration of lung function with massive distension and com- pression of lung parenchyma with consequent mediastinal shift in the course of chronic interstitial lung disease. This situation requires adequate clinical and radiological interpretation in order to make the proper patient selection i.e., between a candidate for lung biopsy for the benefit of a definitive diagnosis or one who in the course of a superimposed ALIE requires a diagnostic and therapeutic lobectomy. Two cases of this entity and descriptive decision-making diagnostic and surgical about pre-and intraop- erative findings are presented.

  1. Protective effect of carvacrol on acute lung injury induced by lipopolysaccharide in mice.

    Science.gov (United States)

    Feng, Xiaosheng; Jia, Aiqing

    2014-08-01

    Carvacrol, the major component of Plectranthus amboinicus, has been known to exhibit anti-inflammatory activities. The aim of this study was to investigate the effects of carvacrol on lipopolysaccharide (LPS)-induced endotoxemia and acute lung injury (ALI) in mice. Mice were injected intraperitoneally (i.p.) with LPS and the mortality of mice for 7 days were observed twice a day. Meanwhile, the protective effect of carvacrol (20, 40 or 80 mg/kg) on LPS-induced endotoxemia were detected. Using an experimental model of LPS-induced ALI, we examined the effect of carvacrol in resolving lung injury. The results showed that carvacrol could improve survival during lethal endotoxemia and attenuate LPS-induced ALI in mice. The anti-inflammatory mechanisms of carvacrol may be due to its ability to inhibit NF-κB and MAPKs signaling pathways, thereby inhibiting inflammatory cytokines TNF-α, IL-6 and IL-1β production.

  2. Galangin dampens mice lipopolysaccharide-induced acute lung injury.

    Science.gov (United States)

    Shu, Yu-Sheng; Tao, Wei; Miao, Qian-Bing; Lu, Shi-Chun; Zhu, Ya-Bing

    2014-10-01

    Galangin, an active ingredient of Alpinia galangal, has been shown to possess anti-inflammatory and antioxidant activities. Inflammation and oxidative stress are known to play vital effect in the pathogenesis of acute lung injury (ALI). In this study, we determined whether galangin exerts lung protection in lipopolysaccharide (LPS)-induced ALI. Male BALB/c mice were randomized to receive galangin or vehicle intraperitoneal injection 3 h after LPS challenge. Samples were harvested 24 h post LPS administration. Galangin administration decreased biochemical parameters of oxidative stress and inflammation, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of galangin were associated with inhibition of nuclear factor (NF)-κB and upregulation of heme oxygenase (HO)-1. Galangin reduces LPS-induced ALI by inhibition of inflammation and oxidative stress.

  3. The effects of open lung ventilation on respiratory mechanics and haemodynamics in atelectatic infants after cardiopulmonary bypass.

    Science.gov (United States)

    Cui, Q; Zhou, H; Zhao, R; Liu, J; Yang, X; Zhu, H; Zheng, Q; Gu, C; Yi, D

    2009-01-01

    Acute lung injury (ALI) frequently occurs in infants after cardiopulmonary bypass (CPB) surgery and it sometimes develops into acute respiratory distress syndrome in critically ill infants, which can be life threatening. This study investigated the effects of open lung ventilation on the haemodynamics and respiratory mechanics of 64 infants (34 males; 30 females) with a mean +/- SD age of 8.3 +/- 0.3 months who developed ALI following CPB surgery. Open lung ventilation significantly improved the respiratory mechanics and oxygenation parameters of the infants, including the partial pressure of oxygen in arterial blood (PaO(2)), the ratio of PaO(2)/FiO(2) (fraction of inspired oxygen), peak inspiratory pressure, static compliance and airway resistance. It is concluded that open lung ventilation can greatly improve oxygenation and respiratory mechanics in infants with ALI following CPB surgery.

  4. Grade III Coronary Artery Perforation Following PCI and Unusual Stent Graft Delivery System

    Directory of Open Access Journals (Sweden)

    Sreckovic Miodrag

    2014-06-01

    Full Text Available Koronarne perforacije su retke ali izuzetno neugodne komlikacije perkutanih intervencija. Perforacije koronarnh arterija trećeg stepena po Elisu predstvaljaju najozbiljniju formu perforacija i zahtevaju hitno zbrinjavanje. Često je neophodno uraditi perikardiocentezu i primeniti brojne interventne tehnike kako bismo rešili perforaciju. Stentovi prekriveni politetrafluoroetilenom(PTFE postali su jedno od najčešće korišćenih perkutanih rešenja, ali su njihove mane visoki profil i slaba fleksibilnost. U našem slučaju, pokušali smo da poboljšamo plasiranje PTFE stenta montiranjem na metalni stent, koji smo iskoristili kao nosač.

  5. Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice

    Directory of Open Access Journals (Sweden)

    Junya Kawai

    2014-01-01

    Full Text Available Pleurotus eryngii (P. eryngii is consumed as a fresh cultivated mushroom worldwide and demonstrated to have multiple beneficial effects. We investigated the anti-inflammatory effect of P. eryngii in mice with acute lung injury (ALI. Intranasal instillation of lipopolysaccharide (LPS (10 μg/site/mouse induced marked lung inflammation (increase in the number of inflammatory cells, protein leakage, and production of nitric oxide in bronchoalveolar lavage fluid as well as histopathological damage in the lung, 6 h after treatment. Mice administered heat-treated P. eryngii (0.3–1 g/kg, p.o. (HTPE 1 h before LPS challenge showed decreased pulmonary inflammation and ameliorated histopathological damage. These results suggest that HTPE has anti-inflammatory effects against ALI. Thus, P. eryngii itself may also have anti-inflammatory effects and could be a beneficial food for the prevention of ALI induced by bacterial infection.

  6. Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus.

    Directory of Open Access Journals (Sweden)

    Jianwu Bai

    Full Text Available Human airway epithelial cells are the principal target of human rhinovirus (HRV, a common cold pathogen that triggers the majority of asthma exacerbations. The objectives of this study were 1 to evaluate an in vitro air liquid interface cultured human airway epithelial cell model for HRV infection, and 2 to identify gene expression patterns associated with asthma intrinsically and/or after HRV infection using this model.Air-liquid interface (ALI human airway epithelial cell cultures were prepared from 6 asthmatic and 6 non-asthmatic donors. The effects of rhinovirus RV-A16 on ALI cultures were compared. Genome-wide gene expression changes in ALI cultures following HRV infection at 24 hours post exposure were further analyzed using RNA-seq technology. Cellular gene expression and cytokine/chemokine secretion were further evaluated by qPCR and a Luminex-based protein assay, respectively.ALI cultures were readily infected by HRV. RNA-seq analysis of HRV infected ALI cultures identified sets of genes associated with asthma specific viral responses. These genes are related to inflammatory pathways, epithelial structure and remodeling and cilium assembly and function, including those described previously (e.g. CCL5, CXCL10 and CX3CL1, MUC5AC, CDHR3, and novel ones that were identified for the first time in this study (e.g. CCRL1.ALI-cultured human airway epithelial cells challenged with HRV are a useful translational model for the study of HRV-induced responses in airway epithelial cells, given that gene expression profile using this model largely recapitulates some important patterns of gene responses in patients during clinical HRV infection. Furthermore, our data emphasize that both abnormal airway epithelial structure and inflammatory signaling are two important asthma signatures, which can be further exacerbated by HRV infection.

  7. Effects of Female Sex Hormones on Susceptibility to HSV-2 in Vaginal Cells Grown in Air-Liquid Interface.

    Science.gov (United States)

    Lee, Yung; Dizzell, Sara E; Leung, Vivian; Nazli, Aisha; Zahoor, Muhammad A; Fichorova, Raina N; Kaushic, Charu

    2016-08-30

    The lower female reproductive tract (FRT) is comprised of the cervix and vagina, surfaces that are continuously exposed to a variety of commensal and pathogenic organisms. Sexually transmitted viruses, such as herpes simplex virus type 2 (HSV-2), have to traverse the mucosal epithelial lining of the FRT to establish infection. The majority of current culture systems that model the host-pathogen interactions in the mucosal epithelium have limitations in simulating physiological conditions as they employ a liquid-liquid interface (LLI), in which both apical and basolateral surfaces are submerged in growth medium. We designed the current study to simulate in vivo conditions by growing an immortalized vaginal epithelial cell line (Vk2/E6E7) in culture with an air-liquid interface (ALI) and examined the effects of female sex hormones on their growth, differentiation, and susceptibility to HSV-2 under these conditions, in comparison to LLI cultures. ALI conditions induced Vk2/E6E7 cells to grow into multi-layered cultures compared to the monolayers present in LLI conditions. Vk2 cells in ALI showed higher production of cytokeratin in the presence of estradiol (E2), compared to cells grown in progesterone (P4). Cells grown under ALI conditions were exposed to HSV-2-green fluorescent protein (GFP) and the highest infection and replication was observed in the presence of P4. Altogether, this study suggests that ALI cultures more closely simulate the in vivo conditions of the FRT compared to the conventional LLI cultures. Furthermore, under these conditions P4 was found to confer higher susceptibility to HSV-2 infection in vaginal cells. The vaginal ALI culture system offers a better alternative to study host-pathogen interactions.

  8. Bronchoscopy-derived correlates of lung injury following inhalational injuries: a prospective observational study.

    Directory of Open Access Journals (Sweden)

    Samuel W Jones

    Full Text Available BACKGROUND: Acute lung injury (ALI is a major factor determining morbidity following burns and inhalational injury. In experimental models, factors potentially contributing to ALI risk include inhalation of toxins directly causing cell damage; inflammation; and infection. However, few studies have been done in humans. METHODS: We carried out a prospective observational study of patients admitted to the NC Jaycees Burn Center who were intubated and on mechanical ventilation for burns and suspected inhalational injury. Subjects were enrolled over an 8-month period and followed till discharge or death. Serial bronchial washings from clinically-indicated bronchoscopies were collected and analyzed for markers of cell injury and inflammation. These markers were compared with clinical markers of ALI. RESULTS: Forty-three consecutive patients were studied, with a spectrum of burn and inhalation injury severity. Visible soot at initial bronchoscopy and gram negative bacteria in the lower respiratory tract were associated with ALI in univariate analyses. Subsequent multivariate analysis also controlled for % body surface area burns, infection, and inhalation severity. Elevated IL-10 and reduced IL-12p70 in bronchial washings were statistically significantly associated with ALI. CONCLUSIONS: Independently of several factors including initial inhalational injury severity, infection, and extent of surface burns, high early levels of IL-10 and low levels of IL-12p70 in the central airways are associated with ALI in patients intubated after acute burn/inhalation injury. Lower airway secretions can be collected serially in critically ill burn/inhalation injury patients and may yield important clues to specific pathophysiologic pathways.

  9. Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series

    Directory of Open Access Journals (Sweden)

    Castellote José

    2011-07-01

    Full Text Available Abstract Background Acute liver injury (ALI induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug. The aim is to describe the characteristics of patients admitted to hospital with jaundice who had previous exposure to therapeutic doses of paracetamol. An assessment of the causality role of paracetamol was performed in each case. Methods Based on the evaluation of prospectively gathered cases of ALI with detailed clinical information, thirty-two cases of ALI in non-alcoholic patients exposed to therapeutic doses of paracetamol were identified. Two authors assessed all drug exposures by using the CIOMS/RUCAM scale. Each case was classified into one of five categories based on the causality score for paracetamol. Results In four cases the role of paracetamol was judged to be unrelated, in two unlikely, and these were excluded from evaluation. In seven of the remaining 26 cases, the RUCAM score associated with paracetamol was higher than that associated with other concomitant medications. The estimated incidence of ALI related to the use of paracetamol in therapeutic dosages was 0.4 per million inhabitants older than 15 years of age and per year (99%CI, 0.2-0.8 and of 10 per million paracetamol users-year (95% CI 4.3-19.4. Conclusions Our results indicate that paracetamol in therapeutic dosages may be considered in the causality assessment in non-alcoholic patients with liver injury, even if the estimated incidence of ALI related to paracetamol appears to be low.

  10. POZNAVANJE PLANETOV PRI UČENCIH NA RAZREDNI STOPNJI IZOBRAŽEVANJA

    OpenAIRE

    Makovec, Julijana

    2009-01-01

    Namen raziskave je ugotoviti poznavanje planetov med učenci nižjih razredov osnovne šole. Zanimalo nas je, koliko učenci poznajo planete po imenu in kako jih prepoznajo na podlagi slikovnega gradiva. V nadaljevanju smo želeli raziskati predstave učencev o planetih in njihovih lastnostih. Pri tem nas je zanimalo, ali učenci poznajo velikosti planetov in razmere na njih in ali ločijo planete od zvezd in naravnih satelitov. Na koncu pa smo preverili še, kaj učenci vedo o opazovanju planetov. Ugo...

  11. Répartition des rôles entre hommes et femmes en zone périurbaine au Mozambique

    OpenAIRE

    Mejia, Margarita

    2016-01-01

    Au sein de notre institution, les enjeux concernant les questions liant genre et environnement sont traités au sein d'un programme intégré sur le développement durable, commencé en 1992. Dans ce cadre, des consultations ont été réalisées, en particulier une étude d'impact social et environnemental dans le cadre du Plan national de Reconstruction. Nous avons également réalisé des évaluations portant sur les infrastructures, les services urbains et la dimension de genre, dans des zones périurba...

  12. Prone positioning ventilation for treatment of acute lung injury and acute respiratory distress syndrome

    Institute of Scientific and Technical Information of China (English)

    LAN Mei-juan; HE Xiao-di

    2009-01-01

    Patients who are diagnosed with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) usually have ventilation-perfusion mismatch, severe decrease in lung capacity, and gas exchange abnormalities. Health care work-ers have implemented various strategies in an attempt to compensate for these pathological alterations. By rotating patients with ALI/ARDS between the supine and prone position, it is possible to achieve a significant improvement in PaO2/FiO2, decrease shunting and therefore improve oxy-genation without use of expensive, invasive and experimen-tal procedures.

  13. OSA Proceedings of the Topical Meeting (5th) on Short-Wave Length Coherent Radiation: Generation and Applications Held in Monterey, California on 8-10 April 1991. Volume 11

    Science.gov (United States)

    1992-05-22

    Richard R. Freeman AT&BeU Laboratories Stephen E. Harris Stanford Univrsity Janos Kinz SUNY?-Stony Brook Howard Mllchberg Univerity of Maryland Harm G...and T. Sugano, Sol. St. Electronics 7, 509 (1964). 6. H.E. Elsayed-Ali, T. Juhasz , G.O. Smith, and W. E. Bron, "Femtosecond Thermomudulation of...Left. 58,1212 (1987); R. W. Schoenlein, W. Z. Lin, J. G. Fujimoto. and G. L. Eesley, Phys. Rev. Left. 58, 1680 (1987). 2. H. E. Elsayed-Ali, T. Juhasz

  14. Beyren-lès-Sierck

    OpenAIRE

    Mangin, Gilles

    2013-01-01

    Identifiant de l'opération archéologique : F1357200100015 Date de l'opération : 2001 (EV) Des sondages ont été réalisés d'urgence par le service régional de l'archéologie de Lorraine suite à un projet de lotir (5 822 m2) où un décapage avait été réalisé avant la phase réglementaire de diagnostic. Aucun vestige archéologique n'a été rencontré.

  15. Aircraft Corrosion

    Science.gov (United States)

    1981-08-01

    qualitd fail-safe de is structure ont Etd vdrifides au cours de l’essai de is cellule de fatigue de cat avion : en effet , une crique, initide sur is...pout subir I& structure de 1’avion hormis lea effets micaniques bien que ces derniers interfirent avec lea agents physico-chlmlques. * G~~ali~e. La...iprouvettes (cylindriques ou iquorres) ont iti solliclties en flexion par llinterrnidiaire d’un bras do levier . Le schima do I& planche 7 donne le

  16. VPLIV NADZORA ZAPOSLENIH NA NJIHOVO VEDENJE IN MOTIVACIJO PRI DELU

    OpenAIRE

    Marinšek, Teja

    2011-01-01

    Nadzor na delovnem mestu je sodoben problem, v katerem smo udeleženi vsi. Z vedno manjšim zaupanjem med nadrejenimi in podrejenimi se nadzor poostruje in s tem se tudi pritiski na delovnem mestu povečujejo. V diplomskem delu smo raziskovali predvsem vpliv nadzora na vedenje človeka. Zanimalo nas je, kako tak pritisk vpliva na človeka in njegove spremembe v obnašanju. Ali nanj to vpliva pozitivno in motivacijsko ali deluje na človeka negativno. Obravnavali smo tudi zakone, ki opredeljujejo...

  17. Modalni glagoli v Da Vinčijevi šifri Dana Browna v izvirniku in prevodu

    OpenAIRE

    Kovačič, Ines

    2009-01-01

    Cilj te diplomske naloge je ugotoviti, kako so angleški modalni glagoli prevedeni v slovenščino in ali obstajajo kakšne podobnosti oziroma razlike med originalom in izvirnikom. Ukvarjala sem se z vprašanjem, ali so bili pri prevodih uporabljeni ustrezni slovenski modalni glagoli oziroma so namesto le-teh uporabljeni drugi izrazi. Prav tako me je zanimala pogostost uporabe modalnih glagolov. Podlaga za analizo je bilo delo The Da Vinci Code – Da Vinčijeva šifra avtorja Dana Browna. Kjiga j...

  18. Pogodba o zdravljenju

    OpenAIRE

    Čater, Amadej

    2016-01-01

    V diplomski nalogi je obravnavana pogodba o zdravljenju. Pogodba o zdravljenju je inominatna pogodba obligacijskega prava, ki v pravnih virih Republike Slovenije ni neposredno urejena. Gre za dvostransko oz. bilateralno sinalgmatično pogodbo, ki je lahko odplačna ali neodplačna. Stranki pogodbe sta zdravnik in pacient, kjer prvi s svojim znanjem in strokovnimi metodami skuša ozdraviti drugega ali pa mu nudi določeno medicinsko storitev. Skleneta jo lahko izrecno, s podpisom pogodbe o zdravlje...

  19. Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis

    Directory of Open Access Journals (Sweden)

    Miyoshi S

    2013-04-01

    Full Text Available Seigo Miyoshi,1 Hironobu Hamada,1,2 Ryoji Ito,1 Hitoshi Katayama,1 Kazunori Irifune,1 Toshimitsu Suwaki,3 Norihiko Nakanishi,4 Takanori Kanematsu,5 Kentaro Dote,6 Mayuki Aibiki,7 Takafumi Okura,1 Jitsuo Higaki1 1Department of Integrated Medicine and Informatics, Ehime University, Graduate School of Medicine, Toon, 2Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 3Department of Respiratory Medicine, Sumitomo Besshi Hospital, Niihama, 4Department of Respiratory Medicine, Ehime Prefectural Central Hospital, Matsuyama, 5Department of Respiratory Medicine, Matsuyama Red Cross Hospital, Matsuyama, 6Intensive Care Division, Ehime University Hospital, Toon, 7Department of Emergency Medicine, School of Medicine, Ehime University, Toon, Japan Background: Neutrophil elastase plays a crucial role in the development of acute lung injury (ALI in patients with systemic inflammatory response syndrome (SIRS. The clinical efficacy of the neutrophil elastase inhibitor, sivelestat, for patients with ALI associated with SIRS has not been convincingly demonstrated. The aim of this study was to determine if there are clinical features of patients with this condition that affect the efficacy of sivelestat. Methods: This was a retrospective study of 110 ALI patients with SIRS. Clinical information, including the etiology of ALI, the number of organs failing, scoring systems for assessing the severity of illness, and laboratory data, was collected at the time of diagnosis. Information on the number of ventilator-free days (VFDs and changes in PaO2/FIO2 (ΔP/F before and 7 days after the time of ALI diagnosis was also collected. The effect of sivelestat on ALI patients was also examined based on whether they had sepsis and whether their initial serum procalcitonin level was ≥0.5 ng/mL. Results: There were 70 patients who were treated with sivelestat and 40 control patients. VFDs and ΔP/F were significantly higher in the treated

  20. VPLIV VSTOPA SLOVENIJE V EVROPSKO UNIJO NA TRŽNE POTI SLOVENSKIH ZAVAROVALNIC

    OpenAIRE

    Kranjc, Marjan

    2011-01-01

    Glavni namen magistrske naloge je raziskati vpliv vstopa Slovenije v EU 1. maja 2004 na slovensko zavarovalništvo s poudarkom na tržnih poteh, ki jih za dosego trženjskih ciljev uporabljajo zavarovalnice v EU, v primerjavi s tržnimi potmi, ki so značilne za slovenske zavarovalnice. Ugotoviti želimo, ali so se alternativne tržne poti, ki so značilne za evropske zavarovalnice v zadnjih nekaj letih že prenesle v Slovenijo, oziroma ali so sploh prave za zelo konzervativno usmerjene slovenske zava...

  1. Pulsed Dose Delivery of Oxygen in Mechanically Ventilated Pigs with Acute Lung Injury

    Science.gov (United States)

    2013-03-01

    ALI is diagnosed, in part, by comparing the ratio of arterial oxygen concentration ( PaO2 ) to the percentage of oxygen in the air used for...breathing (fraction of inspired oxygen, FiO2). ALI is defined as a PaO2 : FiO2 (P:F) ratio of , while a ratio of  is characteristic of acute...P:F ratios were calculated by dividing the PaO2 by the FiO2. All data are expressed as mean ± SD. Student’s t-test was used to compare the data

  2. Advances in Studies on Chemistry,Pharmacological Effect,and Pharmacokinetics of Eurycoma longifolia

    Institute of Scientific and Technical Information of China (English)

    HOU Wen-bin; XIAO Xue-feng; GUO Wei; ZHANG Tie-jun

    2011-01-01

    Eurycoma longifolia,also known as Tongkat Ali in Malaysia,as one of traditional herbal medicines,is used for centuries in South-East Asia.With the discovery of anticancer and anti-HIV properties,this herbal medicine has attracted great attention recently.In this review,the following information on E.longifolia,including chemistry,bioactivities,pharmacokinetics,clinical studies,and side effects and safety,was introduced.Our results,to a certain extent,will provide scientific base for commercial utilization and clearance of the Tongkat Ali products with regard to consumers' safety.

  3. DIGITALNO MARKETINŠKO KOMUNICIRANJE V PODJETJU SIMOBIL D.D.

    OpenAIRE

    Cajnko, Katja

    2015-01-01

    Digitalni marketing oz. marketinško komuniciranje je relativno nov tehnološki izraz, ki je izbruhnil v svet industrije. Opredelimo ga lahko kot promocijsko izpostavljenost izdelkov ali svetovnih blagovnih znamk skozi eno ali več oblik družbenega mreženja. Povzroča pravi gospodarski razcvet, medtem ko so tradicionalne marketinške metode postale manj dobičkonosne in zastarele ter se v veliki večini osredinjajo samo na televizijske in časopisne oglase. Njegov obstoj ne gre jemati kot luksuzen...

  4. Socialnoekonomska in prostorska problematika samotnih kmetij v KS Črna

    Directory of Open Access Journals (Sweden)

    Marijan M. Klemenčič

    1986-12-01

    Full Text Available Samotne kmetije so posebna oblika poselitve, ki sloni na bolj ali manj gospodarsko samostojnih in prostorsko izoliranih ali vsaj med seboj slabo povezanih enotah. Bolj kot pri kateremkoli drugem tipu poselitve sloni ta poselitev na družinski instituciji: s propadom družine propade celotna gospodarska celica, ki jo predstavlja samotna kmetija. O pomenu poselitve v obliki samotnih kmetij ni potrebno izgubljati besed, posebno to še velja za obmejna in narodnostno občutljiva območja.

  5. NIZKO TEMPERATURNE ADSORPCIJSKE HLADILNE NAPRAVE

    OpenAIRE

    Vodušek, Bogdan

    2014-01-01

    Veliko energije se porabi za ogrevanje ter hlajenje prostorov. Ena izmed možnih rešitev hlajenja ali ogrevanja je z adsorpcijsko hladilno napravo, ki lahko koristi odpadno toploto ali sončno energijo, ker je ekonomsko učinkovitejše in okolju prijaznejše od uporabe kompresorskih in drugih hladilnih naprav. Diplomska naloga vključuje teoretične osnove različnih zasnov adsorpcijskih hladilnih naprav in simulacijo delovanja adsorpcijske hladilne naprave s programom Aspen Plus. V diplomskem delu s...

  6. Kashmir -- Key to Stability

    Science.gov (United States)

    1966-04-08

    223. 1]lbid. As a means of pressure on Kashmir to accede to Pakistan, which was clearly assumed by Mohammed Ali Jinnah , Prime Minister of...would meet with Mohammed Ali Jinnah , the newly appointed Governor-General of Pakistan. Because ol illness Mr. Nehru did not I 8 make (he meeting. Mr...1 . INT [ODVC1 ION I Prelude 1 Purpose 2 2, THE KASHMIR DISPUTE 3 Gene r.i 1 3 Kashmi r 4 Partit ion 7 Invasion oi Kashmir by

  7. L'exraction par micro-ondes: un choix de qualité

    OpenAIRE

    Ramdani, M.; Ghazi, Z.; Fadel, O.; Mouni, L.; Wathelet, Jean-Paul

    2010-01-01

    Le but de ce travail est de comparer l’extraction faite par chauffage classique (CC) avec celle réalisée sous micro-ondes (MO). Deux modes d’extraction ont été réalisés : - L’hydro-distillation par chauffage classique (extraction par entraînement à la vapeur d’un solvant) et, - L’hydro-distillation activée par micro-ondes. Les MO permettent un gain de temps considérable. Par exemple, dans le cas du lavandula dentata : on note une cinétique 3 fois plus rapide, de plus le rendement ...

  8. Allergic Lung Inflammation Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice

    DEFF Research Database (Denmark)

    Liu, Cong-Lin; Wang, Yi; Liao, Mengyang

    2016-01-01

    OBJECTIVE: Asthma and abdominal aortic aneurysms (AAA) both involve inflammation. Patients with asthma have an increased risk of developing AAA or experiencing aortic rupture. This study tests the development of one disease on the progression of the other. APPROACH AND RESULTS: Ovalbumin...... sensitization and challenge in mice led to the development of allergic lung inflammation (ALI). Subcutaneous infusion of angiotensin II into mice produced AAA. Simultaneous production of ALI in AAA mice doubled abdominal aortic diameter and increased macrophage and mast cell content, arterial media smooth...

  9. Arcobacter spp.

    OpenAIRE

    Filipović, Ivana; Zdolec, Nevijo; Benussi Skukan, Andrea

    2007-01-01

    Bakterije roda Arcobacter pripadaju porodici Campylobacteriaceae, no od Campylobacter vrsta razlikuje se po sposobnosti rasta na 15 °C i u aerobnim uvjetima. Ove bakterije izolirane su iz oboljelih životinja, ljudi, ali i s trupova životinja nakon klaoničke obrade, te svježeg mesa, kao i vode. Farmske životinje, posebice perad, smatraju se rezervoarima bakterije. Razvijene su različite mikrobiološke metode za izolaciju Arcobacter spp., ali standardni protokol još uvijek ne postoji. Za brzu i ...

  10. Imagining Defeat: An Arabic Historiography of the Crusades

    Science.gov (United States)

    2007-03-01

    Ali Habibah, al-Muslimun wa-al-salibiyun (Cairo: Maktabat al-Shabab, 1990). 172 `Ali Habibah, Sira ` fi al-Sharq (Cairo: Maktabat al-Shabab, 1994...176 Ibid 9-15. 177 Ibid, 18-20. (author’s translation from the Arabic) See also Habibah, Sira ` fi al-Sharq, 3-5, for an almost word-for-word...Muslimun wa-al-salibiyun. Cairo: Maktabat al-Shabab, 1990. ———. Sira ` fi al-Sharq. Cairo: Maktabat al-Shabab, 1994. Habashi, Hasan. al-Harb al

  11. 急性肺损伤/急性呼吸窘迫综合征新生儿血清Clara细胞分泌蛋白、肺表面活性蛋白A变化的意义%Significance of changes of serum Clara cell secretory protein 16, pulmonary surfactant protein A in newborn infants with acute lung injury/acute respiratory distress syndrome

    Institute of Scientific and Technical Information of China (English)

    刘改英; 林广; 刘颖; 王艳芳; 张成; 刘芳; 马海燕; 郭锐

    2013-01-01

    Objective To investigate the effect of serum Clara cell secretory protein 16 (CC16),pulmonary surfactant protein A(SP-A) in diagnosis of acute lung injury (ALI)/acute respiratory distress syndrome(ARDS) in newborn infants.Methods Fifty ALI/ARDS newborn infants in Zhuhai People's Hospital between 2011 Sep.and Dec.2012 were selected as treatment group (ALI group including 35 cases,ARDS group including 15 cases),50 healthy newborns were selected as healthy control group.The changes of serum CC16,SP-A were detected by enzyme-linked immuno sorbent assay and were compared in the 3 groups.Results 1.Serum CC16 in ALI group and ARDS group were (34.19 ± 1.09) mg/L,(55.28 ± 0.82) mg/L,respectively,which were significantly higher than that in healthy control group [(12.67 ± 1.10) mg/L] (all P < 0.05),and there was significant difference between ALI group and ARDS group(P <0.05).2.Serum SP-A in ALI group and ARDS group were(56.78 ± 3.48) mg/L,(70.23 ± 5.14) mg/L respectively,which were significantly higher than that in healthy control group [(22.10 ± 3.32) mg/L] (all P < 0.05),and there was significant difference between ALI group and ARDS group (P < 0.05).Conclusion Serum CC16,SP-A can be effective parameter for early monitoring ALI/ARDS in newborn infants.%目的 探讨血清Clara细胞分泌蛋白(CC16)、肺表面活性蛋白A(SP-A)在新生儿急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)诊断中的作用.方法 选取2011年9月至2012年12月珠海市人民医院收治的50例ALI/ARDS新生儿作为观察组,其中ALI组35例,ARDS组15例;将同期健康体检的50例新生儿作为健康对照组.采用ELISA法检测3组患儿血清CC16及SP-A水平,比较3组患儿血清CC16、SP-A水平的变化.结果 1.血清CC 16:ALI组[(34.19 ±1.09) mg/L]、ARDS组[(55.28 ±0.82) mg/L]明显高于健康对照组[(12.67±1.10)mg/L](P均<0.05),且ALI组与ARDS组比较差异亦有统计学意义(P<0.05).2.血清SP-A:ALI组[(56.78±3.48) mg

  12. Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury.

    Science.gov (United States)

    Wu, Deqing; Zeng, Yue; Fan, Yuting; Wu, Jianghong; Mulatibieke, Tunike; Ni, Jianbo; Yu, Ge; Wan, Rong; Wang, Xingpeng; Hu, Guoyong

    2016-02-04

    Junctional adhesion molecule-C (JAM-C) plays a key role in the promotion of the reverse transendothelial migration (rTEM) of neutrophils, which contributes to the dissemination of systemic inflammation and to secondary organ damage. During acute pancreatitis (AP), systemic inflammatory responses lead to distant organ damage and typically result in acute lung injury (ALI). Here, we investigated the role of rTEM neutrophils in AP-associated ALI and the molecular mechanisms by which JAM-C regulates neutrophil rTEM in this disorder. In this study, rTEM neutrophils were identified in the peripheral blood both in murine model of AP and human patients with AP, which elevated with increased severity of lung injury. Pancreatic JAM-C was downregulated during murine experimental pancreatitis, whose expression levels were inversely correlated with both increased neutrophil rTEM and severity of lung injury. Knockout of JAM-C resulted in more severe lung injury and systemic inflammation. Significantly greater numbers of rTEM neutrophils were present both in the circulation and pulmonary vascular washout in JAM-C knockout mice with AP. This study demonstrates that during AP, neutrophils that are recruited to the pancreas may migrate back into the circulation and then contribute to ALI. JAM-C downregulation may contribute to AP-associated ALI via promoting neutrophil rTEM.

  13. ANALISIS KINERJA KEUANGAN PERUSAHAAN PT. ASURANSI JIWASRAYA (PERSERO) CABANG SULAWESI SELATAN

    OpenAIRE

    ARIANTY, ASTRI

    2012-01-01

    ANALISIS KINERJA KEUANGAN PERUSAHAAN PT. ASURANSI JIWASRAYA (PERSERO) CABANG SULAWESI SELATAN COMPANY FINANCIAL PERFORMANCE ANALYSIS PT. INSURANCE JIWASRAYA (LIMITED) SOUTH BRANCH SULAWESI Astri Arianty Prof. Dr. H. Muhammad Ali, SE., M.S Drs. Armayah Sida, M.Si Analisis terhadap kinerja keuangan perusahaan sangat penting dilakukan untuk mengetahui sejauh mana tingkat pencapaian yang telah diperoleh perusahaan sebagaimana tujuan perusahaan dalam menjalankan proses produk...

  14. SWARMS: Scalable sWarms of Autonomous Robots and Mobile Sensors

    Science.gov (United States)

    2013-03-18

    Decision and Control (CDC). 2010/12/15 00:00:00, Atlanta, GA, USA. : , 10/24/2011 19.00 Victor M. Preciado, Alireza Tahbaz-Salehi, Ali Jadbabaie. On...Conference on Control & Its Applications, Baltimore, MD, USA, Jul 2011 13. Bullo, Hugo Schuck Best Paper Award, American Automatic Control Council, 2011

  15. 31 CFR Appendix A to Chapter V - Alphabetical Listing of Blocked Persons, Blocked Vessels, Specially Designated Nationals...

    Science.gov (United States)

    2010-07-01

    ... al-Khaliq; a.k.a. GHAFUR, Humam Abdel Khaleq Abdel; a.k.a. RASHID, Humam 'abd al-Khaliq); DOB 1945... TRADING LLC, Ali Rashid Lootah Building, Al Khaleej Street, Al Baraha Area, Dubai, United Arab Emirates; P...; POB Egypt; Chief Ideological Figure of ISLAMIC GAMA'AT (individual) AL RASHID TRUST (a.k.a. AL...

  16. 75 FR 38211 - Alphabetical Listing of Blocked Persons, Blocked Vessels, Specially Designated Nationals...

    Science.gov (United States)

    2010-07-01

    .... RASHID, Humam 'abd al- Khaliq); DOB 1945; POB ar-Ramadi, Iraq; nationality Iraq; Former Minister of..., Algeria (individual) AL AMLOOD TRADING LLC, Ali Rashid Lootah Building, Al Khaleej Street, Al Baraha Area... Ideological Figure of ISLAMIC GAMA'AT (individual) AL RASHID TRUST (a.k.a. AL AMEEN TRUST; a.k.a. AL...

  17. The Jobs behind the Science

    CERN Multimedia

    Jacques Fichet; Jules Ordan; Anna Cook; Jacques Fichet

    2015-01-01

    Recruitments service promotes this clip "The Jobs behind the Science" Réalisé par Jules Ordan Produit par Jacques Fichet Voix off Anna Cook Musique : Unphased. Les musiciens: - Carlos Rosales - Tim McGarry - Ary Porat - Elio Jaillet - Jules Ordan - Didier Fellay

  18. Oats

    Science.gov (United States)

    ... with HIV. A one-gram increase in total dietary fiber may decrease the risk of fat accumultion by ... Stramentum, Avoine, Avoine Entière, Avoine Sauvage, Cereal Fiber, Dietary Fiber, Farine d’Avoine, Fibre Alimentaire, Fibre Céréalière, Fibre ...

  19. Arctigenin attenuates lipopolysaccharide-induced acute lung injury in rats.

    Science.gov (United States)

    Shi, Xianbao; Sun, Hongzhi; Zhou, Dun; Xi, Huanjiu; Shan, Lina

    2015-04-01

    Arctigenin (ATG) has been reported to possess anti-inflammatory properties. However, the effects of ATG on lipopolysaccharide (LPS)-induced acute lung injury (ALI) remains not well understood. In the present study, our investigation was designed to reveal the effect of ATG on LPS-induced ALI in rats. We found that ATG pretreatment attenuated the LPS-induced ALI, as evidenced by the reduced histological scores, myeloperoxidase activity, and wet-to-dry weight ratio in the lung tissues. This was accompanied by the decreased levels of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-1 (IL-6) in the bronchoalveolar lavage fluid. Furthermore, ATG downregulated the expression of nuclear factor kappa B (NF-κB) p65, promoted the phosphorylation of inhibitor of nuclear factor-κB-α (IκBα) and activated the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPKα) in the lung tissues. Our results suggested that ATG attenuates the LPS-induced ALI via activation of AMPK and suppression of NF-κB signaling pathway.

  20. Terrorism, Insurgency, and Afghanistan

    Science.gov (United States)

    2007-02-01

    Afghanistan and Kashmir, through groups such as Lashkar e-Tayyiba (LT), Jaish-e-Mohammed (JEM), Jamiat Ulema- i-Islam’s Fazlur Rehman faction (JUI-F...British dubbed them “Mad Mullah movements.” There have been many. A similar figure to Mullah Omar, Mirza Ali Khan —a Tori KhelWaziri whowas known to