WorldWideScience

Sample records for ali

  1. Tibet's Ali: Asia's Atacama?

    OpenAIRE

    Ye, Quan-Zhi; Su, Meng; Li, Hong; Zhang, Xinmin

    2015-01-01

    The Ngari (Ali) prefecture of Tibet, one of the highest areas in the world, has recently emerged as a promising site for future astronomical observation. Here we use 31 years of reanalysis data from the Climate Forecast System Reanalysis (CFSR) to examine the astroclimatology of Ngari, using the recently-erected Ali Observatory at Shiquanhe (5~047~m above mean sea level) as the representative site. We find the percentage of photometric night, median atmospheric seeing and median precipitable ...

  2. ALIS deployment in Cambodia

    Science.gov (United States)

    Sato, Motoyuki; Takahashi, Kazunori

    2012-06-01

    Dual sensor is one of the most promising sensors for humanitarian demining operations. Conventional landmine detection depends on highly trained and focused human operators manually sweeping 1m2 plots with a metal detector and listening for characteristic audio signals indicating the presence of AP (Anti-personnel) landmines. In order to reduce the time of plodding detected objects, metal detectors need to be combined with a complimentary subsurface imaging sensor. i.e., GPR(Ground Penetrating Radar). The demining application requires real-time imaging results with centimetre resolution in a highly portable package. We are currently testing a dual sensor ALIS which is a real-time sensor tracking system based on a CCD camera and image processing. In this paper we introduce ALIS systems which we have developed for detection of buried antipersonnel mines and small size explosives. The performance of ALIS has been tested in Cambodia since 2009. More than 80 anti-personnel mines have been detected and removed from local agricultural area. ALIS has cleared more than 70,000 m2 area and returned it to local farmers.

  3. Tibet's Ali: Asia's Atacama?

    CERN Document Server

    Ye, Quan-Zhi; Li, Hong; Zhang, Xinmin

    2015-01-01

    The Ngari (Ali) prefecture of Tibet, one of the highest areas in the world, has recently emerged as a promising site for future astronomical observation. Here we use 31 years of reanalysis data from the Climate Forecast System Reanalysis (CFSR) to examine the astroclimatology of Ngari, using the recently-erected Ali Observatory at Shiquanhe (5~047~m above mean sea level) as the representative site. We find the percentage of photometric night, median atmospheric seeing and median precipitable water vapor (PWV) of the Shiquanhe site to be $57\\%$, $0.8"$ and 2.5~mm, comparable some of the world's best astronomical observatories. Additional calculation supports the Shiquanhe region as one of the better sites for astronomical observations over the Tibetan Plateau. Based on the studies taken at comparable environment at Atacama, extraordinary observing condition may be possible at the few vehicle-accessible 6~000~m heights in the Shiquanhe region. Such possibility should be thoroughly investigated in future.

  4. AliPDU Package Upgrade

    CERN Document Server

    "Martin, Michael

    2015-01-01

    "AliPDU Package" is a set of script, panels, and datapoints designed in WinCC to manage and monitor PDU's. PDU is an essential component in the data center, in order to make data center working properly through the monitoring of power distribution and environmental condition of the data center. In this project "AliPDU Package" is upgraded so it can be used to monitor environmental condition of data center using PDU's and external environmental sensor connected to PDU.

  5. AliPDU Package Upgrade

    CERN Document Server

    Martin, Michael

    2015-01-01

    AliPDU Package is a set of script, panels, and datapoints designed in WinCC to manage and monitor PDU's. PDU is an essential component in the data center, in order to make data center working properly through the monitoring of power distribution and environmental condition of the data center. In this project "AliPDU Package" is upgraded so it can be used to monitor environmental condition of data center using PDU's and external environmental sensor connected to PDU.

  6. AliEn Resource Brokers

    CERN Document Server

    Saiz, P; Peters, A J; Saiz, Pablo; Buncic, Predrag; Peters, Andreas J.

    2003-01-01

    AliEn (ALICE Environment) is a lightweight GRID framework developed by the Alice Collaboration. When the experiment starts running, it will collect data at a rate of approximately 2 PB per year, producing O(109) files per year. All these files, including all simulated events generated during the preparation phase of the experiment, must be accounted and reliably tracked in the GRID environment. The backbone of AliEn is a distributed file catalogue, which associates universal logical file name to physical file names for each dataset and provides transparent access to datasets independently of physical location. The file replication and transport is carried out under the control of the File Transport Broker. In addition, the file catalogue maintains information about every job running in the system. The jobs are distributed by the Job Resource Broker that is implemented using a simplified pull (as opposed to traditional push) architecture. This paper describes the Job and File Transport Resource Brokers and sho...

  7. Effects of Splenectomy on Spontaneously Chronic Pancreatitis in aly/aly Mice

    Directory of Open Access Journals (Sweden)

    Heng-Xiao Wang

    2010-01-01

    Full Text Available Background and Aim. Mice with alymphoplasia (aly/aly mutation characterized by a lack of lymph nodes, Peyer's patches, and well-defined lymphoid follicles in the spleen were found. In this study, we used splenectomized aly/aly mice to elucidate the effects of secondary lymphoid organs in the development of aly/aly autoimmune pancreatitis. Methods. Forty-eight 10-week-old aly/aly mice were divided into two groups for splenectomy and sham operation. Histological and immunohistochemical analyses of the pancreas were performed at the ages of 20, 30, and 40 weeks old after operation, respectively. Results. Our results showed that mononuclear cell infiltration was restricted to the interlobular connective tissues at the age of 20 weeks, and not increase obviously at the age of 30 and 40 weeks in splenectomized aly/aly mice. Furthermore, an apparent decrease in the expressions of CD4+ T, CD8+ T, and B cells was detected in the pancreatic tissues compared with sham aly/aly mice, however, no significant difference in macrophage expression between mice with and without a splenectomy. Conclusions. Inflammation infiltration and development of the pancreatitis in aly/aly mice were suppressed effectively after splenectomy, which was, at least partly, correlated to inhibition of the infiltration of T and B cells in pancreatic tissues but not to macrophages.

  8. AliEn - EDG Interoperability in ALICE

    OpenAIRE

    Bagnasco, S.; Barbera, R.; Buncic, P.; Carminati, F.; P. Cerello; Saiz, P.

    2003-01-01

    AliEn (ALICE Environment) is a GRID-like system for large scale job submission and distributed data management developed and used in the context of ALICE, the CERN LHC heavy-ion experiment. With the aim of exploiting upcoming Grid resources to run AliEn-managed jobs and store the produced data, the problem of AliEn-EDG interoperability was addressed and an in-terface was designed. One or more EDG (European Data Grid) User Interface machines run the AliEn software suite (Cluster Monitor, Stora...

  9. AliEn - EDG Interoperability in ALICE

    CERN Document Server

    Bagnasco, S; Buncic, P; Carminati, F; Cerello, P G; Saiz, P

    2003-01-01

    AliEn (ALICE Environment) is a GRID-like system for large scale job submission and distributed data management developed and used in the context of ALICE, the CERN LHC heavy-ion experiment. With the aim of exploiting upcoming Grid resources to run AliEn-managed jobs and store the produced data, the problem of AliEn-EDG interoperability was addressed and an in-terface was designed. One or more EDG (European Data Grid) User Interface machines run the AliEn software suite (Cluster Monitor, Storage Element and Computing Element), and act as interface nodes between the systems. An EDG Resource Broker is seen by the AliEn server as a single Computing Element, while the EDG storage is seen by AliEn as a single, large Storage Element; files produced in EDG sites are registered in both the EDG Replica Catalogue and in the AliEn Data Catalogue, thus ensuring accessibility from both worlds. In fact, both registrations are required: the AliEn one is used for the data management, the EDG one to guarantee the integrity and...

  10. Entretien avec Ali Ben Makhlouf

    Directory of Open Access Journals (Sweden)

    2005-04-01

    Full Text Available Ali Benmakhlouf est actuellement maître de conférences à l’Université de Paris-X Nanterre. Spécialiste de logique et des œuvres de Frege, Russel et Whitehead, il est par ailleurs depuis dix ans la cheville ouvrière de la convention passée entre la Fondation du Roi Abdul Aziz pour les études islamiques et les sciences humaines (Casablanca et le Collège international de Philosophie (Paris. Cinq volumes, publiés par les éditions Le Fennec en français et en arabe, témoignent de cet échange : La Raison et la question des limites (1997, Routes et déroutes de l’universel (1998, Le voyage des théories (2000, Tout est-il relatif ? (2001 et Droit et participation politique (20021. L’entretien qu’il a accordé à Asterion met en évidence les enjeux d’un tel travail commun pour la philosophie et sa pratique.

  11. Surfactant Therapy of ALI and ARDS

    OpenAIRE

    Raghavendran, K; Willson, D; Notter, RH

    2011-01-01

    This article examines exogenous lung surfactant replacement therapy and its utility in mitigating clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Biophysical research has documented that lung surfactant dysfunction can be reversed or mitigated by increasing surfactant concentration, and multiple studies in animals with ALI/ARDS have shown that respiratory function and pulmonary mechanics in vivo can be improved by exogenous surfactant administration. Exoge...

  12. ALIED: A Theory of Lie Detection

    OpenAIRE

    Street, Chris N. H.

    2016-01-01

    We are very inaccurate lie detectors, and tend to believe what others tell us is the truth more often than we ought to. In fact, studies on lie detection typically describe our tendency to believe others as an error in judgment. Although people may look like hopeless lie detectors, the Adaptive Lie Detector theory (ALIED) claims that people are actually making smart, informed judgments. This article explores the ALIED theory and what it means for those wanting to spot a liar.

  13. ALIED: A Theory of Lie Detection

    Directory of Open Access Journals (Sweden)

    Chris N. H. Street

    2016-07-01

    Full Text Available We are very inaccurate lie detectors, and tend to believe what others tell us is the truth more often than we ought to. In fact, studies on lie detection typically describe our tendency to believe others as an error in judgment. Although people may look like hopeless lie detectors, the Adaptive Lie Detector theory (ALIED claims that people are actually making smart, informed judgments. This article explores the ALIED theory and what it means for those wanting to spot a liar.

  14. AliEnFS - a Linux File System for the AliEn Grid Services

    OpenAIRE

    Peters, Andreas J.; Saiz, P.; Buncic, P.

    2003-01-01

    Among the services offered by the AliEn (ALICE Environment http://alien.cern.ch) Grid framework there is a virtual file catalogue to allow transparent access to distributed data-sets using various file transfer protocols. $alienfs$ (AliEn File System) integrates the AliEn file catalogue as a new file system type into the Linux kernel using LUFS, a hybrid user space file system framework (Open Source http://lufs.sourceforge.net). LUFS uses a special kernel interface level called VFS (Virtual F...

  15. Analysis list: aly-2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available aly-2 Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/aly-2.1....tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/aly-2.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/al...y-2.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/aly-2.Larvae.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

  16. AliEn: ALICE Environment on the GRID

    CERN Multimedia

    Bagnasco, S; Buncic, P; Carminati, F; Cirstoiu, C; Grigoras, C; Hayrapetyan, A; Harutyunyan, A; Peters, A J; Saiz, P

    2007-01-01

    Starting from mid-2008, the ALICE detector at CERN LHC will collect data at a rate of 4PB per year. ALICE will use exclusively distributed Grid resources to store, process and analyse this data. The top-level management of the Grid resources is done through the AliEn (ALICE Environment) system, which is in continuous development since year 2000. AliEn presents several original solutions, which have shown their viability in a number of large exercises of increasing complexity called Data Challenges. This paper describes the AliEn architecture: Job Management, Data Management and UI. The current status of AliEn will be illustrated, as well as the performance of the system during the data challenges. The paper also describes the future AliEn development roadmap.

  17. AliEn: ALICE environment on the GRID

    International Nuclear Information System (INIS)

    Starting from mid-2008, the ALICE detector at CERN LHC will collect data at a rate of 4PB per year. ALICE will use exclusively distributed Grid resources to store, process and analyse this data. The top-level management of the Grid resources is done through the AliEn (ALICE Environment) system, which is in continuous development since year 2000. AliEn presents several original solutions, which have shown their viability in a number of large exercises of increasing complexity called Data Challenges. This paper describes the AliEn architecture: Job Management, Data Management and UI. The current status of AliEn will be illustrated, as well as the performance of the system during the data challenges. The paper also describes the future AliEn development roadmap

  18. AliEn: ALICE Environment on the GRID

    CERN Document Server

    CERN. Geneva

    2012-01-01

    AliEn is the GRID middleware used by the ALICE collaboration. It provides all the components that are needed to manage the distributed resources. AliEn is used for all the computing workflows of the experiment: Montecarlo production, data replication and reconstruction and organixed or chaotic user analysis. Moreover, AliEn is also being used by other experiments like PANDA and CBM. The main components of AliEn are a centralized file and metadata catalogue, a job execution model and file replication model. These three components have been evolving over the last 10 years to make sure that the satisfy the computing requirements of the experiment, which keep increasing every year.

  19. Evaluation test of ALIS in Cambodia for humanitarian demining

    Science.gov (United States)

    Sato, Motoyuki

    2010-04-01

    ALIS is a hand-held dual sensor developed by Tohoku University, Japan since 2002. Dual sensor is a general name of sensor for humanitarian demining, which are equipped with metal detector and GPR. ALIS is only one hand-held dual sensor, which can record the sensor position with sensor signals. Therefore, the data can be processed after data acquisition, and can increase the imaging capability. ALIS has been tested in some mine affected courtiers including Afghanistan (2004), Egypt(2005), Croatia(2006-) and Cambodia(2007-). Mine fields at each country has different conditions and soil types. Therefore testes at the real mine fields are very important. ALIS has detected more than 30 AP-Mines in evaluation test in Cambodia held in 2009.

  20. AliEn - ALICE environment on the GRID

    International Nuclear Information System (INIS)

    AliEn (http://alien.cern.ch) (ALICE Environment) is a Grid framework built on top of the latest Internet standards for information exchange and authentication (SOAP, PKI) and common Open Source components. AliEn provides a virtual file catalogue that allows transparent access to distributed datasets and a number of collaborating Web services which implement the authentication, job execution, file transport, performance monitor and event logging. In the paper we will present the architecture and components of the system

  1. AliEn - GRID application for ALICE Collaboration

    International Nuclear Information System (INIS)

    AliEn (ALICE Environment) is a GRID framework built on top of the latest Internet standards for information exchange and authentication (SOAP, PKI) and common Open Source components. AliEn provides a virtual file catalogue that allows transparent access to distributed data-sets and a number of collaborating Web services which implement the authentication, job execution, file transport, performance monitor and event logging.The ALICE experiment has developed AliEn as an implementation of distributed computing infrastructure needed to simulate, reconstruct and analyze data from the experiment. The sites that belong to the ALICE Virtual Organisation can be seen and used as a single entity - any available node executes jobs and access to logical and datasets is transparent to the user. In developing AliEn common standards and solutions in the form of Open Source components were used. Only 1% (25k physical lines of code in Perl) is native AliEn code while 99% of the code has been imported in form of Open Sources packages and Perl modules. Currently ALICE is using the system for distributed production of Monte Carlo data at over 30 sites on four continents. During the last twelve months more than 30,000 jobs have been successfully run under AliEn control worldwide, totalling 25 CPU years and producing 20 TB of data. The user interface is compatible to EU DataGrid at the level of authentication and job description language. In perspective AliEn will be interfaced to the mainstream Grid infrastructure in HEP and it will remain to serve as interface between ALICE Offline framework and external Grid infrastructure. (authors)

  2. Site Protection Program and Progress Report of Ali Observatory, Tibet

    Science.gov (United States)

    Yao, Yongqiang; Zhou, Yunhe; Wang, Xiaohua; He, Jun; Zhou, Shu

    2015-08-01

    The Ali observatory, Tibet, is a promising new site identified through ten year site survey over west China, and it is of significance to establish rules of site protection during site development. The site protection program is described with five aspects: site monitoring, technical support, local government support, specific organization, and public education. The long-term sky brightness monitoring is ready with site testing instruments and basic for light pollution measurement; the monitoring also includes directions of main light sources, providing periodical reports and suggestions for coordinating meetings. The technical supports with institutes and manufacturers help to publish lighting standards and replace light fixtures; the research pays special attention to the blue-rich sources, which impact the important application of high altitude sites. An official leading group towards development and protection of astronomical resources has been established by Ali government; one of its tasks is to issue regulations against light pollution, including special restrictions of airport, mine, and winter heating, and to supervise lighting inspection and rectification. A site protection office under the official group and local astronomical society are organized by Ali observatory; the office can coordinate in government levels and promote related activities. A specific website operated by the protection office releases activity propaganda, evaluation results, and technical comparison with other observatories. Both the site protection office and Ali observatory take responsibility for public education, including popular science lectures, light pollution and energy conservation education. Ali Night Sky Park has been constructed and opens in 2014, and provides a popular place and observational experience. The establishment of Ali Observatory and Night Sky Park brings unexpected social influence, and the starry sky trip to Ali becomes a new format of culture

  3. The AliEn system, status and perspectives

    CERN Document Server

    Buncic, P; Peters, A J

    2003-01-01

    AliEn is a production environment that implements several components of the Grid paradigm needed to simulate, reconstruct and analyse HEP data in a distributed way. The system is built around Open Source components, uses the Web Services model and standard network protocols to implement the computing platform that is currently being used to produce and analyse Monte Carlo data at over 30 sites on four continents. The aim of this paper is to present the current AliEn architecture and outline its future developments in the light of emerging standards.

  4. The AliEn system, status and perspectives

    OpenAIRE

    Buncic, P.; Saiz, P.; Peters, A J

    2003-01-01

    AliEn is a production environment that implements several components of the Grid paradigm needed to simulate, reconstruct and analyse HEP data in a distributed way. The system is built around Open Source components, uses the Web Services model and standard network protocols to implement the computing platform that is currently being used to produce and analyse Monte Carlo data at over 30 sites on four continents. The aim of this paper is to present the current AliEn architecture and outline i...

  5. Izraba alternativnih energij: etično ali ne?

    OpenAIRE

    Brodnjak, Tadeja

    2014-01-01

    Diplomska naloga predstavlja različne načine izrabe alternativnih virov nekoč in danes. Drugo poglavje opredeljuje alternativne vire in njihove možnosti uporabe na praktičnih primerih. Sledimo v opredeljevanje celotne skupine alternativnih obnovljivih virov, kot so sončna energija, vodna energija, raba biomase in geotermalne energije. V tretjem poglavju se lotimo vprašanja, ali je ravnanje ljudi z energetskimi viri etično ali ne, saj se moramo zavedati, da smo ljudje največji sovražniki na...

  6. Suurajatolla Ali al-Sistani saabus Najaffi / Kalev Vilgats

    Index Scriptorium Estoniae

    Vilgats, Kalev

    2004-01-01

    Mässulise shiiidivaimuliku Moqtada al-Sadri Mahdi armee võitlejad on pidanud Najafis USA vägedega lahinguid juba kolm nädalat. Iraagi kõrgeim shiiiavaimulik suurajatolla Ali al-Sistani kutsub kõiki iraaklasi endaga Najaffi marssima, et lahingutele lõpp teha

  7. Enhancing the AliEn Web Service Authentication

    International Nuclear Information System (INIS)

    Web Services are an XML based technology that allow applications to communicate with each other across disparate systems. Web Services are becoming the de facto standard that enable inter operability between heterogeneous processes and systems. AliEn2 is a grid environment based on web services. The AliEn2 services can be divided in three categories: Central services, deployed once per organization; Site services, deployed on each of the participating centers; Job Agents running on the worker nodes automatically. A security model to protect these services is essential for the whole system. Current implementations of web server, such as Apache, are not suitable to be used within the grid environment. Apache with the modssl and OpenSSL only supports the X.509 certificates. But in the grid environment, the common credential is the proxy certificate for the purpose of providing restricted proxy and delegation. An Authentication framework was taken for AliEn2 web services to add the ability to accept X.509 certificates and proxy certificates from client-side to Apache Web Server. The authentication framework could also allow the generation of access control policies to limit access to the AliEn2 web services.

  8. Exhaled breath analysis discriminates phenotypes of acute lung injury (ALI)

    OpenAIRE

    Bos, L.D.J.; Hemmes, S.N.T.; Nijsen, T.M.E.; P. J. Sterk; Schultz, M.J

    2012-01-01

    Introduction It has been postulated that the pathophysiology and clinical presentation of ALI based on pulmonary and non-pulmonary etiology represent different phenotypes1. Until now, little biological evidence on the molecular level has been presented to support this hypothesis. Exhaled air contains volatile organic compounds (VOCs), metabolites of systemic or respiratory origin. Exhaled air metabolites may differ between diseases2. Molecular profiling of exhaled air of intubated and mechani...

  9. The final story on the ALA3/ALIS1 complex

    DEFF Research Database (Denmark)

    Lopez Marques, Rosa Laura

    mutant were phenotypically analyzed. When grown under 24 h light conditions, mutant plants are significantly smaller than control wild type plants. A decrease in root growth is related to the inability of ala3 plants to release border-like cells from root caps that are damaged during root penetration.......         Together with ALIS1, we have found that ALA3, localises to the Golgi apparatus in plant cells. Expression of a ß-glucuronidase (GUS) gene under the control of the promoter for either ALIS1 or ALA3 showed a high expression level for both promoters at the columella root cap. Two independent lines of ala3...... of the growth medium. Electron micrographs show cellular defects in cells of the root cap of mutant plants related to the formation of vesicles in the trans side of the Golgi apparatus. We propose that the flippase activity of the ALA3/ALIS1 complex in the Golgi is required for important secretory processes...

  10. Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy.

    Science.gov (United States)

    Stubbs, Sarah H; Conrad, Nicholas K

    2015-01-01

    Pre-mRNA processing is mechanistically linked to transcription with RNA pol II serving as a platform to recruit RNA processing factors to nascent transcripts. The TREX complex member, REF/Aly, has been suggested to play roles in transcription and nuclear RNA stability in addition to its more broadly characterized role in mRNA export. We employed RNA-seq to identify a subset of transcripts with decreased expression in both nuclear and cytoplasmic fractions upon REF/Aly knockdown, which implies that REF/Aly affects their expression upstream of its role in mRNA export. Transcription inhibition experiments and metabolic labeling assays argue that REF/Aly does not affect stability of selected candidate transcripts. Instead, ChIP assays and nuclear run-on analysis reveal that REF/Aly depletion diminishes the transcription of these candidate genes. Furthermore, we determined that REF/Aly binds directly to candidate transcripts, supporting a direct effect of REF/Aly on candidate gene transcription. Taken together, our data suggest that the importance of REF/Aly is not limited to RNA export, but that REF/Aly is also critical for gene expression at the level of transcription. Our data are consistent with the model that REF/Aly is involved in linking splicing with transcription efficiency.

  11. Peran Mukti Ali dalam Pengembangan Toleransi Antar Agama di Indonesia

    Directory of Open Access Journals (Sweden)

    Khairah Husin

    2014-06-01

    Full Text Available Agama sebagai sasaran kajian penelitian sudah banyak dilakukan oleh para sarjana disiplin ilmu. Mereka melakukan penelitian terhadap berbagai aspek dari agama, baik aspek ide maupun aspek perwujudan dalam kenyataan. Dimulai dari keyakinan dan ajaran yang dimiliki oleh suatu agama hingga pengaruh agama pada kehidupan masyarakat pemeluk agama tersebut. Kalau yang dimaksud metode dalam ilmu perbandingan agama adalah cara untuk memperoleh dan mamahami kebenaran agama dari realitas empiris, atau lebih tepatnya “kebenaran ilmiah agamis”, maka pendekatan tiada lain adalah suatu sikap ilmiah (persepsi dari seorang yang harus ditunjukkan untuk menemukan kebenaran ilmiah yang hendak diperoleh. Dengan demikian pendekatan sifatnya umum. Dalan suatu pendekatan tertentu dapat digunakan bermacammacam metode, umpamanya seorang Sosiolog akan mengkaji agama pasti akan menerapkan pendekatan metode-metode sosiologis. Begitu pula Sejarawan, Antropolog, Fenomenolog, dan lain-lain akan menerapkan pendekatan dan metode sesuai dengan latar belakang keahliannya. Maka sasaran ideal dari beberapa pendekatan adalah memperoleh interelasi yang sistematis dari fakta-fakta agama, dan bertujuan untuk mencari jawaban tentang fakta-fakta tersebut dengan menggunakan kesangsian sistematis. Pendekatan keilmuan dalam meneliti agama mencoba mendeskripsikan dunia pemeluk agama secara apa adanya (das sein, bukan didasarkan semestinya secara normatif (das sollen. Dengan demikian, pendekatan keilmuan yang empiris ini menggunakan dan mengadaptasi pendekatanpendekatan ilmu-ilmu sosial dan budaya. Dari sekian tokoh ilmu Perbandingan Agama, kebanyakan dari mereka merupakan ilmuwan Barat. Namun demikian ada juga beberapa tokoh perbandingan agama dari duni Islam, antara lain adalah Prof. Dr. H.A. Mukti Ali, Ibnu Hazm dan As-Syahrastani. Sementara Ibnu Hazm Al Andalusy dan As-Syahrastani merupakan tokoh-tokoh Perbaga Muslim dari zaman klasik – zaman ketika Perbaga belum terbentuk sebagai

  12. Viral factors reveal a role for REF/Aly in nuclear RNA stability.

    Science.gov (United States)

    Stubbs, Sarah H; Hunter, Olga V; Hoover, Ashley; Conrad, Nicholas K

    2012-04-01

    TREX is a conserved multiprotein complex that is necessary for efficient mRNA export to the cytoplasm. In Saccharomyces cerevisiae, the TREX complex is additionally implicated in RNA quality control pathways, but it is unclear whether this function is conserved in mammalian cells. The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein binds and recruits the TREX component REF/Aly to viral mRNAs. Here, we demonstrate that REF/Aly is recruited to the KSHV noncoding polyadenylated nuclear (PAN) RNA by ORF57. This recruitment correlates with ORF57-mediated stabilization of PAN RNA, suggesting that REF/Aly promotes nuclear RNA stability. Further supporting this idea, tethering REF/Aly to PAN RNA is sufficient to increase the nuclear abundance and half-life of PAN RNA but is not sufficient to promote its export. Interestingly, REF/Aly appears to protect the poly(A) tail from deadenylation, and REF/Aly-stabilized transcripts are further adenylated over time, consistent with previous reports linking poly(A) tail length with nuclear RNA surveillance. These studies show that REF/Aly can stabilize nuclear RNAs independently of their export and support a broader conservation of RNA quality control mechanisms from yeast to humans.

  13. Dynamic virtual AliEn Grid sites on Nimbus with CernVM

    International Nuclear Information System (INIS)

    We describe the work on enabling one click deployment of Grid sites of AliEn Grid framework on the Nimbus 'science cloud' at the University of Chicago. The integration of computing resources of the cloud with the resource pool of AliEn Grid is achieved by leveraging two mechanisms: the Nimbus Context Broker developed at Argonne National Laboratory and the University of Chicago, and CernVM - a baseline virtual software appliance for LHC experiments developed at CERN. Two approaches of dynamic virtual AliEn Grid site deployment are presented.

  14. The similarity of Ali (as and Jesus (PBUH in Islamic tradition

    Directory of Open Access Journals (Sweden)

    Sorush Ghanbari

    2016-01-01

    Full Text Available According to the teachings of the Shia, Imam Ali (AS has unique features by which he earned the merits of becoming the successor to the Prophet (pbuh as the Imam and Wali. One of the most important of his features is his similarity to the Jesus as one of the greatest prophets before Prophet Muhammad (pbuh. This similarity was first mentioned in some Islamic traditions, especially the ones narrated through Shiite Isnad in interpretation of the verses 57-59 of the Surta Az-Zukhruf. In these traditions, the Prophet has regarded the Position of Imam Ali (AS in his nation the same as Jesus's Position among the Israel. The Quran has cited the inimical arguments of the Arab infidels against this prophet's saying: they considered the worshiping of their own gods better than accepting Prophet's remark in equating his cousin with Jesus (pbuh. By resorting to this remark, the infidels regarded worshiping their own gods more preferable than deifying a man. Therefore, the first and most prominent similarity between Imam Ali (AS and Jesus Christ (pbuh is attributing divinity to Imam Ali (AS, at least by some of his extreme lovers. The Quranic command saying: "Do not Exaggerate about your religion… .(Quran 4:17 refers to the Christian extremism in deifying Jesus, But soon word Ghali was borrowed from this verse and used to refer to Shiite extremists. Moreover, the Quran (4: 159, talks about the advent of Jesus Christ to his followers before their death .The same concept has been mentioned in Shiite traditions about Imam Ali (AS, according to which, he is believed to be present beside every dying Muslim individual. This appearance of Imam Ali (AS would remind us the idea of Imam Ali's (AS return to this world. Thus, the return of Imam Ali (AS to this world is the third similarity between Imam Ali (AS and Jesus Christ (PBUH. Not only the return of Jesus has been mentioned in in the Christian tradition as the one manifested to the apostles after his ascension

  15. Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

    DEFF Research Database (Denmark)

    Afshari, Arash; Brok, Jesper; Møller, Ann;

    2010-01-01

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are critical conditions that are associated with high mortality and morbidity. Aerosolized prostacyclin has been used to improve oxygenation despite the limited evidence available so far....

  16. Gaia16ali and Gaia16alj supernovae confirmed by Euler imaging

    Science.gov (United States)

    Roelens, M.; Blanco-Cuaresma, S.; Semaan, T.; Palaversa, L.; Mowlavi, N.; Eyer, L.

    2016-04-01

    We report confirmation of Gaia Science Alerts transients Gaia16ali and Gaia16alj. Images were obtained through modified Gunn R band filter of the ECAM instrument installed on the Swiss 1.2m Euler telescope at La Silla, on 2016 April 19 - 22 UT. These new sources are supernovae candidates and they are not visible in archival 2MASS and DSS images: Gaia16ali (near centre of galaxy GALEXASC J041551.89-621715.5) and Gaia16alj.

  17. Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

    DEFF Research Database (Denmark)

    Afshari, Arash; Brok, Jesper; Møller, Ann;

    2010-01-01

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are critical conditions that are associated with high mortality and morbidity. Aerosolized prostacyclin has been used to improve oxygenation despite the limited evidence available so far.......Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are critical conditions that are associated with high mortality and morbidity. Aerosolized prostacyclin has been used to improve oxygenation despite the limited evidence available so far....

  18. ASTER, ALI and Hyperion sensors data for lithological mapping and ore minerals exploration

    OpenAIRE

    Beiranvand Pour, Amin; Hashim, Mazlan

    2014-01-01

    This paper provides a review of the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), Advanced Land Imager (ALI), and Hyperion data and applications of the data as a tool for ore minerals exploration, lithological and structural mapping. Spectral information extraction from ASTER, ALI, and Hyperion data has great ability to assist geologists in all disciplines to map the distribution and detect the rock units exposed at the earth’s surface. The near coincidence of Earth ...

  19. Preliminary studies on the extraction of Glycospanonins in Tongkat Ali extract

    Science.gov (United States)

    Abirame, S.; Sivakumar, K.; Chua, L. S.; Sarmidi, M. R.

    2016-06-01

    Eurycoma longifolia, locally known as Tongkat Ali, is a famous medicinal plant in the family of Simaroubaceae and well known for its aphrodisiac properties from its water extract. The root of E. longifolia is used to extract wide range bioactive components of Tongkat Ali. Previous works standardised Tongkat Ali extracts by measuring the concentration of eurycomanone, a quassinoid marker chemical, within the overall extract. There is a newer Malaysian standard that specifies that Tongkat Ali can be standardised to glycosaponin, thus it is desired to determine how extraction parameters such as particle size, extraction temperature, and solvent type affects the glycosaponin content in the extract. The overall study is aimed to determine how the extraction parameters affect the glycosaponin amount in extract. This paper presents the preliminary work where in this study the effect of particle size on overall extract and glycosaponin quantification method development is presented. A reflux extraction method was used to extract Tongkat Ali with a particle size of 0.5 mm, 1.0 mm and 2.0 mm of raw material to study effect of particle size on overall extract. Water and methanol were the two types of solvent used for extraction to study the quantity of glycosaponin.

  20. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future perspectives of therapies

    OpenAIRE

    Luh, Shi-Ping; Chiang, Chi-huei

    2006-01-01

    Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), which manifests as non-cardiogenic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/AR...

  1. Upright position mechanical ventilation: an alternative strategy for ALI/ARDS patients?

    Science.gov (United States)

    Zhu, Min; Zhang, Wei; Wang, Jia-Ning; Yan, Hua; Li, Yang-Kai; Ai, Bo; Fu, Sheng-Lin; Fu, Xiang-Ning

    2009-11-01

    Use of body positioning to improve oxygenation in mechanically ventilated patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) has been well documented. However, neither prone position ventilation nor side lying ventilation has been reported to improve the survival. Whether there is a body position superior to routine supine position or other positions as therapeutic adjunct for ventilated patients with ALI and ARDS? We propose the hypothesis that upright position ventilation may be helpful to improve oxygenation and benefit patients with ALI/ARDS. According to the existing physiologic and pathophysiologic data of upright position investigation, we suppose that improvement of V/Q matching, increased functional residual capacity, alveolar recruitment, accelerated diaphragm recovery, early gastric emptying and enteric feeding may be a potential protect mechanism of upright position ventilation. Whether this can be translated into improvement in patient outcome should be further tested in clinical trial. PMID:19683402

  2. PRENOVA PROCESA UVAJANJA NOVEGA MODELA ALI TIPA IZDELKA DO FAZE PRIPRAVE NA PROIZVODNJO

    OpenAIRE

    Gavez, Alenka

    2012-01-01

    V Gorenju, d. d., uvajanje novih modelov ali tipov izdelkov upravljamo s procesom Osvajanje izvedenk. Pri tem procesu gre za osvajanje novega modela ali tipa že obstoječega izdelka in ga vedno začnemo v Trženju. Ugotovili smo, da procesa osvajanja novih izvedenk že vrsto let nismo bistveno spremenili, kljub temu da se je v zadnjih letih močno spremenila informacijska tehnologija. Proces še vedno poteka zelo sekvenčno, zaradi česar imamo precej čakalnih časov, informacije niso vedno dovolj ...

  3. Highly pathogenic avian influenza virus nucleoprotein interacts with TREX complex adaptor protein Aly/REF.

    Science.gov (United States)

    Balasubramaniam, Vinod R M T; Hong Wai, Tham; Ario Tejo, Bimo; Omar, Abdul Rahman; Syed Hassan, Sharifah

    2013-01-01

    We constructed a novel chicken (Gallus gallus) lung cDNA library fused inside yeast acting domain vector (pGADT7). Using yeast two-hybrid screening with highly pathogenic avian influenza (HPAI) nucleoprotein (NP) from the strain (A/chicken/Malaysia/5858/2004(H5N1)) as bait, and the Gallus gallus lung cDNA library as prey, a novel interaction between the Gallus gallus cellular RNA export adaptor protein Aly/REF and the viral NP was identified. This interaction was confirmed and validated with mammalian two hybrid studies and co-immunoprecipitation assay. Cellular localization studies using confocal microscopy showed that NP and Aly/REF co-localize primarily in the nucleus. Further investigations by mammalian two hybrid studies into the binding of NP of other subtypes of influenza virus such as the swine A/New Jersey/1976/H1N1 and pandemic A/Malaysia/854/2009(H1N1) to human Aly/REF, also showed that the NP of these viruses interacts with human Aly/REF. Our findings are also supported by docking studies which showed tight and favorable binding between H5N1 NP and human Aly/REF, using crystal structures from Protein Data Bank. siRNA knockdown of Aly/REF had little effect on the export of HPAI NP and other viral RNA as it showed no significant reduction in virus titer. However, UAP56, another component of the TREX complex, which recruits Aly/REF to mRNA was found to interact even better with H5N1 NP through molecular docking studies. Both these proteins also co-localizes in the nucleus at early infection similar to Aly/REF. Intriguingly, knockdown of UAP56 in A549 infected cells shows significant reduction in viral titer (close to 10 fold reduction). Conclusively, our study have opened new avenues for research of other cellular RNA export adaptors crucial in aiding viral RNA export such as the SRSF3, 9G8 and ASF/SF2 that may play role in influenza virus RNA nucleocytoplasmic transport.

  4. A forgotten Ottoman composer: Ali Şîrûganî Dede

    Directory of Open Access Journals (Sweden)

    M. Emin Soydaş

    2007-10-01

    Full Text Available Although being one of the major composers of religious music in the Ottoman era, Ali Şîrûganî Dede, who was famous throughout his life as well as afterwards, is not known nowadays much well as he deserves. In this article Ali Şîrûganî Dede is introduced and information is given on his musicianship and his works, while his situation in the history of Ottoman music is pointed out and especially his importance with regard to religious music is emphasized. Some new information about the subject is also presented within this work.

  5. ALI LAHKO V SLOVENSKEM PRAVNEM REDU GOVORIMO O PRAVICAH ŽIVALI?

    OpenAIRE

    Brežnik, Melita

    2012-01-01

    Pravice živali so v zadnjem času predmet številnih razprav. Povzročajo spore med zagovorniki dobrobiti živali, zagovorniki pravic živali ter ostalo družbo, ali bi živalim morali priznati pravice, če je odgovor pritrdilen, katere in kako jih vključiti v realnost. Ker so pravice živali zelo široka tema, sem se osredotočila na pravni sistem Slovenije. Izpostavila sem vprašanje: Ali lahko v slovenskem pravnem redu govorimo o pravicah živali? V diplomski nalogi sem obravnavala vprašanje iz filozo...

  6. 家蚕Aly/REF的基因克隆、序列分析及其细胞定位%Cloning, sequence analysis and cellular localization of Aly/REF from the silkworm, Bombyx mori

    Institute of Scientific and Technical Information of China (English)

    钟金凤; 曹广力; 薛仁宇; 贡成良

    2011-01-01

    RNA和输出因子结合蛋白(RNA and exportfactor binding proteins,REF/Aly)参与RNA的稳定、加工和输出.本研究参照已公开的家蚕Bombyx mori aly序列(GenBank登录号:DQ497195.1),通过RT-PCR克隆了家蚕aly/ref基因(Bmaly/ref).测序结果显示,该基因的开放读码框为765 bp,编码254个氨基酸残基,BmAly/REF与黑腹果蝇Drosophila melanogaster、小鼠Mus musculus的同源体的氨基酸序列一致性分别为49.7%和52.7%.结构预测结果显示,BmAly/REF具有REF家族的与RNA结合的结构域RRM,N和C端分别具有REF-N和REF-C基序.进化分析结果显示,昆虫的ALY/REF聚为一类,BmAly/REF与赤拟谷盗tribolium castaneum、意大利蜜蜂Apis mellifera的Aly/REF较为接近.将Bmaly/ref基因克隆进pGS21a(+)载体进行原核表达,重组蛋白免疫小鼠,获得鼠抗BmAly/REF多抗.免疫荧光实验结果显示,BmAly/REF在细胞质和细胞核中均有分布,但主要分布在细胞核中.芯片数据分析显示Bmaly/ref基因在家蚕幼虫5龄第3天各组织中均有较高水平的表达.研究结果显示BmAly/REF可能在RNA的核输出方面发挥作用,为进一步探讨BmAly/REF的功能奠定了基础.%RNA and export factor binding proteins (Aly/REF) play important roles in RNA stability, processing and nuclear export. Referring to the sequence of Bombyx mori aly gene ( GenBank accession no. DQ497195.1 ), the aly/refgene (Bmaly/ref) from the silkworm, B. mori, was cloned via RT-PCR. The sequencing result showed that the open reading frame (ORF) of Bmaly/ref is 765 bp in length, encoding 254 amino acid residues, and the amino acid sequence of BmAIy/REF showed 49.7% and 52.7% identities with the homologs of Drosophila melanogaster and Mus musculus, respectively. The structure prediction displayed that BmAIy/REF contains RNA binding domain (RRM), REF-N and REF-C motif of REF subfamily. Phylogenetic analysis showed that the insect Aly/REF proteins clustered to a group and the BmAly/REF was close

  7. 肺损伤预测评分在ALI/ARDS早期诊断中的应用%Evaluation of Lung Injury Prediction Score in Early Identification of Patients at Risk of ALI/ARDS

    Institute of Scientific and Technical Information of China (English)

    夏炎火; 童秋玲; 林锡芳; 王丹; 朱海萍; 戴震宇

    2013-01-01

    目的 评估肺损伤预测评分(LIPS)在早期预测急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)中的价值和可行性.方法 对43例ALI/ARDS患者和32例非ALI/ARDS患者分别进行LIPS、肺损伤评分(LIS)和急性生理学及慢性健康状况(APACHE)Ⅱ评分,计算两组病死率,并对结果进行比较和相关性分析,利用受试者工作特征(ROC)曲线评价LIPS和LIS的诊断分辨度.结果 与非ALI/ARDS组相比,ALI/ARDS组的ICU平均住院时间、LIPS和LIS较高,而PaO2/FiO2相对较低,且病死率高达34.88%.LIPS与LIS呈明显正相关(r=0.669,P<0.001),但LIPS、LIS与APACHEⅡ评分间的相关性不强(r分别为0.460和0.342,P<0.05).LIPS评分对预测ALI/ARDS有意义[曲线下面积(AUC) =0.832,95% CI:0.728 ~0.908,P<0.001],当LIPS>7分时,预测ALI/ARDS的敏感度为83.72%,特异性为78.12%.LIS评分对预测ALI/ ARDS也有意义(AUC=0.802,95% CI:0.693 ~0.885,P<0.001),LIS>0.67分时,预测ALI/ARDS的敏感度、特异性分别为81.40%和77.80%.结论 LIPS对预测ALI/ARDS的准确性较好,且与LIS系统具有较好的相关性,早期即可获得,临床操作性较强,该评分系统为早期预测ALI/ARDS提供了可能.%Objective To evaluate the value and feasibility of lung injury prediction score ( LIPS) in early identification of ALI/ ARDS. Methods The clinical data of 43 ALI/ARDS patients and 32 non - ALI / ARDS patients was collected and evaluated with LIPS, lung injury score(LIS) and APACHE II score system. Mortality of two groups and correlation analysis were evaluated. The forecast value of LIPS and LIS in diagnosis of ALI/ARDS was analyzed by receiver operator characteristic( ROC) curve. Results Compared with non -ALI /ARDS group, the average hospitalization days in ICU, LIPS and LIS of ALI / ARDS group were significantly higher,but the PaO2/ FiO2 was lower. Furthermore, the mortality of ALI/ARDS group was very high (34. 88% ). The LIPS of patients had positive

  8. ALIS-FLP: Amplified ligation selected fragment-length polymorphism method for microbial genotyping

    DEFF Research Database (Denmark)

    Brillowska-Dabrowska, A.; Wianecka, M.; Dabrowski, Slawomir;

    2008-01-01

    A DNA fingerprinting method known as ALIS-FLP (amplified ligation selected fragment-length polymorphism) has been developed for selective and specific amplification of restriction fragments from TspRI restriction endonuclease digested genomic DNA. The method is similar to AFLP, but differs...

  9. Põhja-Küprose liider soovib isolatsiooni lõppemist / Mehmet Ali Talat ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Talat, Mehmet Ali

    2004-01-01

    Põhja-Küprose liidri väitel soovib türklaste kogukond diplomaatilise tunnustuse asemel isolatsiooni lõppemist. Intervjuus käsitletavad teemad: Küprose saare tulevik, liitumine Euroopa Liiduga, Türgi liitumine euroliiduga. Lisad: Kahe kogukonna - kreeklaste ja türklaste - vahel lõhestatud Küpros; Mehmet Ali Talat

  10. Deployment of dual-sensor ALIS for humanitarian demining in Cambodia

    Science.gov (United States)

    Sato, M.; Takahashi, K.

    2013-06-01

    We are in the process of developing a high-resolution landmine scanning system "ALIS" which produces horizontal slices of the shallow subsurface for visualization of buried explosives and inert clutter. As many AP mines contain minimum amounts of metal, metal detectors need to be combined with a complimentary subsurface imaging sensor. Ground Penetrating Radar (GPR) is widely accepted for subsurface sensing in the fields of geology, archaeology and utility detection. The demining application requires real-time imaging results with centimetre resolution in a highly portable package. The key requirement for sharp images of the subsurface is the precise tracking of the geophysical sensor(s) during data collection. We should also notice that GPR system is a very wide band radar system, and equivalent to UWB radar, which has recently been developed for short-range high-accuracy radar. We are testing simplified but effective signal processing for imaging mines. We are currently testing a dual sensor ALIS which is a realtime sensor tracking system based on a CCD camera and image processing. In this paper we introduce the GPR systems which we have developed for detection of buried antipersonnel mines and small size explosives. ALIS has been deployed in Cambodia since 2009 and detected more than 70 mines in mine fields, and returned more than 13ha cleaned fields to local farmers. We also report the current status of ALIS in Cambodia.

  11. Cellular and molecular mechanisms of ACE2/Ang1-7/Mas in ALI/ARDS%ACE2/Ang1-7/Mas在ALI/ARDS中作用机制研究

    Institute of Scientific and Technical Information of China (English)

    孙佳; 朱彪

    2016-01-01

    Renin-angiotensin system(RAS)plays important roles in the pathogenesis of acute lung injury(ALI)/acute respiratory distress syndrome(ARDS).About 60% of ARDS patients are shown to develop pulmonary fibrosis with increased mortality rate.Recent researches have demonstrated potent inhibitory of angiotensin-converting enzyme 2 (ACE2)/angiotensin 1-7 (Ang1-7)/Mas axis on ALI/ARDS.This review summarizes the beneficial action of ACE2/Ang1-7/Mas on ALI/ARDS and research progress on relative signaling pathway.%肾素-血管紧张素系统在 ALI/ARDS的病理过程中有重要作用。大约60% ARDS患者进展成肺纤维化且其病死率明显增加。目前研究显示 ACE/AngⅡ/AT1 R 与 ALI/ARDS 发病机制有关,而ACE2/Ang1-7/Mas起负向调节作用———ACE2和Ang1-7对ALI/ARDS有保护作用。因此,本文就 ACE2/Ang1-7/Mas在 ALI/ARDS中的保护作用和相关信号传导通路等方面最新研究进展作一阐述。

  12. ALIED: Una teoría de la detección de mentiras

    Directory of Open Access Journals (Sweden)

    Chris N. H. Street

    2016-07-01

    Full Text Available En general, somos torpes a la hora de detectar mentiras y tendemos a creer que los demás dicen la verdad con más frecuencia de la que deberíamos. De hecho, los estudios sobre detección de mentiras suelen describir nuestra tendencia a creer a otras personas como un error de juicio. Aunque parezcamos irremediablemente malos a la hora de detectar mentiras, la teoría del Detector de Mentiras Adaptativo (ALIED afirma que, en realidad, hacemos juicios inteligentes y bien informados. Este artículo explora la teoría ALIED y sus implicaciones para quienes deseen pillar a un mentiroso.

  13. PESANTREN AND MODERNITY IN INDONESIA: MA’HAD ALY OF KUNINGAN

    Directory of Open Access Journals (Sweden)

    Didin Nurul Rosidin

    2012-12-01

    Full Text Available In Indonesia where the majority of the population is Muslims, pesantren that has thrived since the arrival of Islam to the shore of the archipelago is still out of the central field of the national educational system. As such, pesantren was and is forced to continually be aware with ongoing new educational developments in the country as the result of modernisation and globalisation. The foundation of Ma’had Aly is one of the ways taken by the pesantrens to response to the current developments within Muslim communities, to define or even maintain their central roles as well as to preserve their tradition in such a modernised and globalised Indonesia. By exploring the foundation of Ma’had Alys in Kuningan as a case study, this article closely elaborates how the pesantren world engages these processes both in their cirricular settings and practices and provides how it negotiates with the ongoing changes within its surrounding communities.

  14. Theoretical description of slow non-monotonic relaxation processes in Al-Y melts

    OpenAIRE

    Vasin, M. G.; Menshikova, S. G.; Ivshin, M. D.

    2015-01-01

    The slow non-monotonic relaxation processes, which have been recently fixed in Al-Y melts, are described theoretically. The theoretical description is based on the Cahn-Hilliard theory and functional methods of non-equilibrium dynamics. In terms of the suggested approach the reasons of this relaxation kinetics are non-linearity of the system near to the liquidus line, which sharply increases with Y concentration, and strong initial heterogeneity of the melt on the concentration of Y atoms. Ac...

  15. Vizija organizacij: poslovni evangeliji, navigacijski simboli ali strateško izhodišče:

    OpenAIRE

    Gruban, Brane

    1998-01-01

    Oblikovanje vizij je poizkus artikulirati želeno prihodnost organizacij z namenom diferenciacije organizacije v okolju in motiviranja zaposlenih v njej za prispevek skupnim ciljem organizacije. Snovanje vizij organizacij v praksi pogosto ne preseže navadnega oblikovanja "oglaševalsko" naravnanih sporočil ali pa opredeljene vizije nimajo ustreznih povezav s cilji, strategijo in vrednotami organizacij. Vizije so pogosto slabo komuniciranje, zato je v procesu njihove artikulacije in udejanjanja ...

  16. Ali Yaşar Sarıbay (1952 - …)

    OpenAIRE

    D. Ali ARSLAN

    2011-01-01

    Ali Yaşar Sarıbay was searched in this study. He is one of the most important social scientist in contemporary Turkey. A critical literature review accomplished on the first stage. Following this, a rather detailed interview schedule with mostly open-ended (unstructured) questions were prepared. And than, a very successful and productive face to face interview was realised with the author.

  17. Comment on "Black Hole with Quantum Potential," by A. F. Ali and M. M. Khalil

    CERN Document Server

    Culetu, Hristu

    2015-01-01

    Few comments upon Ali and Khalil article were pointed out. Their modified Schwarzschild metric seems not to be new as it has the same structure as Eq.(2.6) from Ref.3. Their black hole temperature T and the heat capacity C correspond exactly to the Reissner-Nordtstrom values, with $\\hbar \\eta$ instead of $Q^{2}$. The expression for the black hole entropy turns out to be wrong and does not fit with the other authors' calculations.

  18. Quality and storage characteristics of yogurt containing Lacobacillus sakei ALI033 and cinnamon ethanol extract

    OpenAIRE

    Choi, Yu Jin; Jin, Hee Yeon; Yang, Hee Sun; Lee, Sang Cheon; Huh, Chang Ki

    2016-01-01

    Background This study was conducted to examine the quality and storage characteristics of yogurt containing antifungal-active lactic acid bacteria (ALH, Lacobacillus sakei ALI033) isolated from kimchi and cinnamon ethanol extract. The starter was used for culture inoculation (1.0 % commercial starter culture YF-L812 and ALH). Results The antifungal activity of cinnamon extracts was observed in treatments with either cinnamon ethanol extracts or cinnamon methanol extracts. Changes in fermented...

  19. Implementation and performance analysis of Soft Killer background subtraction method in the AliROOT framework

    CERN Document Server

    Schlag, Bastian

    2016-01-01

    The Soft Killer background subtraction method removes the softest particles up to a certain transverse momentum cut-off threshold in an event. The applied threshold is determined dynamically on an event-by-event basis. The aim of this project was to implement the Soft Killer subtraction method within the AliROOT framework and to study the performance in the LHC energy regime for p-p and Pb-Pb collision systems.

  20. ADDITIONAL BRACHIOPOD FINDINGS FROM THE LOPINGIAN SUCCESSION OF THE ALI BASHI MOUNTAINS, NW IRAN

    Directory of Open Access Journals (Sweden)

    CLAUDIO GARBELLI

    2014-03-01

    Full Text Available Aim of this note is to describe additional findings of Lopingian brachiopods along the Main Valley section and at Localities 1, 3, and 4 of the Ali Bashi Mountains, N Iran. Here we provide:1 taxonomic descriptions of two newly recorded taxa, one of which is a new species, Meekella julfensis n. sp.;2 more information on the stratigraphic range of brachiopods from the Ali Bashi Mountains, which show a greater abundance and diversity in the upper part of the Julfa Formation, in the Ali Bashi Formation, and in the Boundary Clay. The newly collected faunas are characterized by miniaturization which is considered to be a response to deep water conditions in well oxygenated, but trophic resource-limited settings, and not a Lilliput-effect related to the end-Permian crisis;3 a discussion on the phylogenetic relationships between Araxathyris and Transcaucasathyris , proposing that the former may have evolved from the latter by the convergence of the dental plates to form a spondylium, that was probably a structure that functioned to optimize the muscle length in response to greater shell volumes.

  1. JAliEn - A new interface between the AliEn jobs and the central services

    CERN Document Server

    Grigoras, A G; Pedreira, M M; Saiz, P; Schreiner, S

    2014-01-01

    Since the ALICE experiment began data taking in early 2010, the amount of end user jobs on the AliEn Grid has increased signif icantly. Presently 1/3 of the 40K CPU cores available to ALICE are occupied by jobs submitted by about 400 distinct users, individually or in organized analysis trains. The overall stability of the AliEn middleware has been excellent throughout the 3 years of running, but the massive amount of end-user analysis and its specific requirements and load has revealed few components which can be improved. One of them is the interface between users and central AliEn services (catalogue, job submission system) which we are currently re-implementing in Java . The interface provides persistent connection with enhanced data and job submission authenticity. In this paper we will describe the architecture of the new interface, the ROOT binding which enables the use of a single interface in addition to the standard UN IX-like access shell and the new security-related features.

  2. Securing the AliEn File Catalogue - Enforcing authorization with accountable file operations

    International Nuclear Information System (INIS)

    The AliEn Grid Services, as operated by the ALICE Collaboration in its global physics analysis grid framework, is based on a central File Catalogue together with a distributed set of storage systems and the possibility to register links to external data resources. This paper describes several identified vulnerabilities in the AliEn File Catalogue access protocol regarding fraud and unauthorized file alteration and presents a more secure and revised design: a new mechanism, called LFN Booking Table, is introduced in order to keep track of access authorization in the transient state of files entering or leaving the File Catalogue. Due to a simplification of the original Access Envelope mechanism for xrootd-protocol-based storage systems, fundamental computational improvements of the mechanism were achieved as well as an up to 50% reduction of the credential's size. By extending the access protocol with signed status messages from the underlying storage system, the File Catalogue receives trusted information about a file's size and checksum and the protocol is no longer dependent on client trust. Altogether, the revised design complies with atomic and consistent transactions and allows for accountable, authentic, and traceable file operations. This paper describes these changes as part and beyond the development of AliEn version 2.19.

  3. Petrogenesis of skarn related Cu-porphyry intrusion deposit, Ali-Abad- Darreh Zereshk, Yazd

    Directory of Open Access Journals (Sweden)

    Batoul Taghipour

    2011-04-01

    Full Text Available The study area is a part of Cenozoic magmatic belt of Central Iran, which is located in the West of Yazd porovince. Contact metamorphism and skarn occurred in conglomerate part of Sngestan Formation. The Oligocene intrusion bodies of Ali-Abad-Darreh Zereshk are leucocerate and have the chemical composition of granite to granodiorite with calc-alkaline affinity from volcanic arc geological setting. The main mineral assemblage of skarn in order of imprtance is as follow: Garnet + epidote + quartz + calcite + pyrite + iron oxides. Brown garnets are the skarn characteristic mineral. EPMA analysis has shown that the chemical composition with garnet belong to andradite-grossular solid-solution (And 65, Gross 30 with more andradite component. The high permeability and presence of carbonate pebbles in conglomerate are two important factors for fluid flow and genesis of garnets. Distinct oscillatory zoning in garnets is resulted from the change of fO2 in fluids. The evolution of Ali-Abad skarn is took place in the range of 380 to 530 ºC, 0.5 Kbar pressure and high fO2. Also close association of this skarn with Ali-Abad intrusive with Cu-porphyry mineralization shows that this skarn is a Cu-porphyry type skarn.

  4. Relationship between elevated soluble CD74 and severity of experimental and clinical ALI/ARDS

    Science.gov (United States)

    Wu, Guosheng; Sun, Yu; Wang, Kang’an; Chen, Zhengli; Wang, Xingtong; Chang, Fei; Li, Ting; Feng, Ping; Xia, Zhaofan

    2016-01-01

    CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A circulating form of CD74 (soluble CD74, sCD74) was recently discovered in autoimmune liver disease. Using two murine ALI models and cells culture, we examined the presence of sCD74 in circulation and alveolar space and preliminarily assessed the biological function of sCD74. The concentrations of sCD74 were increased in serum and bronchoalveolar lavage fluids (BALF) of murine ALI models. The elevated levels of sCD74 in BALF positively correlated with lung permeability and inflammation. In addition, sCD74 is secreted by macrophages in response to MIF stimulation and itself can stimulate the production of inflammatory cytokines. Our clinical study confirmed some findings of basic research. Moreover, we also found Day 3 serum sCD74 levels were associated with worse clinical outcomes. In conclusion, higher serum sCD74 levels may reflect more severe lung injury and may be used to help physicians determine prognosis of acute respiratory distress syndrome (ARDS). PMID:27444250

  5. Securing the AliEn File Catalogue - Enforcing authorization with accountable file operations

    Science.gov (United States)

    Schreiner, Steffen; Bagnasco, Stefano; Sankar Banerjee, Subho; Betev, Latchezar; Carminati, Federico; Vladimirovna Datskova, Olga; Furano, Fabrizio; Grigoras, Alina; Grigoras, Costin; Mendez Lorenzo, Patricia; Peters, Andreas Joachim; Saiz, Pablo; Zhu, Jianlin

    2011-12-01

    The AliEn Grid Services, as operated by the ALICE Collaboration in its global physics analysis grid framework, is based on a central File Catalogue together with a distributed set of storage systems and the possibility to register links to external data resources. This paper describes several identified vulnerabilities in the AliEn File Catalogue access protocol regarding fraud and unauthorized file alteration and presents a more secure and revised design: a new mechanism, called LFN Booking Table, is introduced in order to keep track of access authorization in the transient state of files entering or leaving the File Catalogue. Due to a simplification of the original Access Envelope mechanism for xrootd-protocol-based storage systems, fundamental computational improvements of the mechanism were achieved as well as an up to 50% reduction of the credential's size. By extending the access protocol with signed status messages from the underlying storage system, the File Catalogue receives trusted information about a file's size and checksum and the protocol is no longer dependent on client trust. Altogether, the revised design complies with atomic and consistent transactions and allows for accountable, authentic, and traceable file operations. This paper describes these changes as part and beyond the development of AliEn version 2.19.

  6. Ali Emirî'nin Osmanlı Tarih ve Edebiyat Mecmuası Ali Emiri's Ottoman History And Literature Periodicals

    Directory of Open Access Journals (Sweden)

    Seher ERDOĞAN ÇELTİK

    2013-03-01

    Full Text Available Periodicals are the documents which constitute resources for ourhistory. A kind of literary atmosphere forms around the magazines;feuilleton novel, story, poetry, critics and similar literary works cometogether with the reader via these magazines. Founder of the PublicLibrary, Ali Emirî published two literary periodicals named OttomanHistory and Literature and History and Literature which are thesuccessor to each other. Totally comprising of 36 issues, the first ispublished as 31 and the latter is published as 5 issues. During theirpublication years, the periodical constituted highly literary atmosphereand this atmosphere undertook an encoring mission in youth’s literaryworks.In this study, these periodicals are introduced and theircontributions to our literary and cultural life are mentioned.First of all Ali Emirî published Ottoman History and Literatureand History and Literature with the aim of being useful for his countryand nation. Later he aimed to illuminate the information/sources ofabout Ottoman history and literature and correct document mistakes.He also wanted to replay to the works that were published as anopposition for him through the magazine and, including Mehmet FuatKöprülü he criticized many other people and institutions.Ali Emiri introduces Divanu Lügati't-Türk to Turkish world. Hewho travelled a lot because of his occupation and thus he continuouslycollected new information and documents. As he enlarged Emirisometimes introduced this information to the readers. Ettik şeref-i hizmet-i ecdâdı ferâmûşÂsârına eslâfımızın rağbet olunmazBir gün bilinir kıymeti mecmûamın ammâPek çok aranır ortada mecmûa bulunmazSüreli yayınlar, edebiyat tarihimize kaynaklık eden dokümanlardandır. Dergiler çevresinde genelde edebî bir muhit oluşur; tefrika roman, hikâye, şiir, tenkit ve benzeri gibi edebî ürünler onlar vasıtasıyla okuyucusuyla buluşur. Millet Kütüphanesinin kurucusu olan Ali Emir

  7. The Anglo-Russian Compromise of 1907 and the Downfall of Mohammad Ali Shah Qajar

    Directory of Open Access Journals (Sweden)

    Nugzar Ter-Oganov

    2015-09-01

    Full Text Available The present paper attempts to show a correlation between the implementation of the Anglo-Russian Convention of 1907 and its direct impact on the Russia's policy in Iran. This paper examines how the signing of that agreement by the Russian Foreign Minister Alexander Petrovich Izwolsky (1906-1910, a devoted supporter of the alliance with Great Britain, led to changes in Russia's policy in Iran, particularly towards Mohammad Ali Shah's authoritarian regime, with crucial consequences for the latter. The author argues that Izwolsky sought to settle the Anglo-Russian rivalry in Asia, particularly in Iran, in return for gaining British support on European issues. In particular, Izwolsky had an obsessive aspiration for Russia to seize the Black Sea Straits in the near future. As the paper will demonstrate, for this objective Izwolsky was ready to make concessions to the British in Iran. The revolutionary events of the end of 1908 and the first part of 1909 in Iran prove that Izwolsky consciously took several steps to arrive at those concessions. Among them was, first of all, the replacement of the experienced Russian Envoy to Tehran Nicolas Genrikhovich Gartvig (Hartwig, a strong opponent to Izwolsky's "liberal" policy in Iran, by the young and weak-willed Charge d'Affaires Evgueni Vasilievich Sablin, in order to give the British ally the upper hand in that country. There are several other clear manifestations of Izwolsky's changing policy towards Iran. First of all, Russian troops suddenly raised the siege of the Iranian city of Tabriz in April 1909 at a time when Russophile Mohammad Ali Shah was very close to demolishing the Constitutional movement. Also the Russian Mission abstained from supporting Mohammad Ali Shah in fighting the Constitutionalists. Notably, it refrained from using the Russian military detachment, which had arrived in Qazvin on July 11, 1909, against the Constitutionalist forces that were advancing towards Tehran. In addition, the

  8. Expounding a Few Key Strategies of Imam Ali (AS on Prevention of Diseases by Means of Improving Nutrition Style

    Directory of Open Access Journals (Sweden)

    Hossein Moradi

    2016-06-01

    Conclusion: Using the guidelines of Imam Ali (AS, new dimensions of prevention practices and treatment of chronic diseases can be achieved. Furthermore, many other hypotheses can be raised making available a wide range of scientific researches

  9. ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.

    Science.gov (United States)

    Taniguchi, Ichiro; Ohno, Mutsuhito

    2008-01-01

    Loading of export factors onto mRNAs is a key step in gene expression. In vertebrates, splicing plays a role in this process. Specific protein complexes, exon junction complex and transcription/export complex, are loaded onto mRNAs in a splicing-dependent manner, and adaptor proteins such as Aly/REF in the complexes in turn recruit mRNA exporter TAP-p15 onto the RNA. By contrast, how export factors are recruited onto intronless mRNAs is largely unknown. We previously showed that Aly/REF is preferentially associated with intronless mRNAs in the nucleus. Here we show that Aly/REF could preferentially bind intronless mRNAs in vitro and that this binding was stimulated by RNA helicase UAP56 in an ATP-dependent manner. Consistently, an ATP binding-deficient UAP56 mutant specifically inhibited mRNA export in Xenopus oocytes. Interestingly, ATP activated the RNA binding activity of UAP56 itself. ATP-bound UAP56 therefore bound to both RNA and Aly/REF, and as a result ATPase activity of UAP56 was cooperatively stimulated. These results are consistent with a model in which ATP-bound UAP56 chaperones Aly/REF onto RNA, ATP is then hydrolyzed, and UAP56 dissociates from RNA for the next round of Aly/REF recruitment. Our finding provides a mechanistic insight into how export factors are recruited onto mRNAs.

  10. Visâlî Ali Çelebi ve Mevlid’i Visâlî Ali Çelebi And His Mevlid

    Directory of Open Access Journals (Sweden)

    Abdülmecit İSLAMOĞLU

    2013-03-01

    Full Text Available Visali Ali Çelebi is one of the XVIth century poets. On the basis of the poet’s work, limited information of his life can be reached. Of this kind of information is that Visali’s name was Ali and hi lived in the time of Suleiman the Magnificent. Poet’s work entitled “Mevlid-i Fahr-i Kâ’inât Muhammedini’l-Mustafâ” is a work composed in the form of mawlid that dealt with the birth of the Prophet, his childhood until seven years of age and some miracles taking place in this period. The only known manuscript copy of Visali Mevlidi is recorded in Türk Dil Kurumu Kütüphanesi, manuscript A/99 numbered. Though the mawlidmost of which was written in the masnawi form of verse, in order toavoid monotony and catch the attention of readers, the verses in theform of qasida/gazel were interspersed throughout text. In the work,intensely, Fâ‘ilâtün Fâ‘ilâtün Fâ‘ilün aruz prosody was used. In theparts written in verse, the language becomes more difficult. It can besaid that in the parts written in the form of masnawi, a plainer lenguageis used. Nevertheless, Arabic-Persian words and phrases are also seenin the Masnawis. In the Mawlid, there also existed completely Arabic orPersian verses. Considering these features, poet’s style and his power inthe field of poetry, it can be said that the work is not simple and fluent.The fat that Mawlid was suddenly finished in the childhood period ofthe Prophet gives the impression that the works was left half finished.However, when the work is compared with other texts written in theform of mawlid, with 1715 verses, it can be categorized among thevoluminous works. In this article, after giving some information aboutthe form and contents of Visali Ali Çelebi’s Mawlid, the transliteratedtext of the only copy of work we could find so far has been presented. Visâlî Ali Çelebi XVI. yüzyıl şairlerindendir. Şairin bilinen tek eseri olan Mevlid’inden yola çıkılarak adının Ali oldu

  11. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALI/ARDS

    Directory of Open Access Journals (Sweden)

    Surender Rajasekaran

    2012-01-01

    Full Text Available Introduction. In the first 48 hours of ventilating patients with acute lung injury (ALI/acute respiratory distress syndrome (ARDS, a multipronged approach including packed red blood cell (PRBC transfusion is undertaken to maintain oxygen delivery. Hypothesis. We hypothesized children with ALI/ARDS transfused within 48 hours of initiating mechanical ventilation would have worse outcome. The course of 34 transfused patients was retrospectively compared to 45 nontransfused control patients admitted to the PICU at Helen DeVos Children’s Hospital between January 1st 2008 and December 31st 2009. Results. Mean hemoglobin (Hb prior to transfusion was 8.2 g/dl compared to 10.1 g/dl in control. P/F ratio decreased from 135.4±7.5 to 116.5±8.8 in transfused but increased from 148.0±8.0 to 190.4±17.8 (P<0.001 in control. OI increased in the transfused from 11.7±0.9 to 18.7±1.6 but not in control. Ventilator days in the transfused were 15.6±1.7 versus 9.5±0.6 days in control (P<0.001. There was a trend towards higher rates of MODS in transfused patients; 29.4% versus 17.7%, odds ratio 1.92, 95% CI; 0.6–5.6 Fisher exact P<0.282. Conclusion. This study suggests that early transfusions of patients with ALI/ARDS were associated with increased ventilatory needs.

  12. Theoretical description of slow non-monotonic relaxation processes in Al-Y melts

    Science.gov (United States)

    Vasin, M. G.; Menshikova, S. G.; Ivshin, M. D.

    2016-05-01

    The slow non-monotonic relaxation processes, which have been recently fixed in Al-Y melts, are described theoretically. The theoretical description is based on the Cahn-Hilliard theory and functional methods of non-equilibrium dynamics. In terms of the suggested approach the reasons of this relaxation kinetics are non-linearity of the system near to the liquidus line, which sharply increases with Y concentration, and strong initial heterogeneity of the melt on the concentration of Y atoms. According to our analysis one can conclude that the non-monotonic temporal dependence of viscosity is caused by the Ostwald ripening processes in the rich in yttrium areas.

  13. Odonata (Insecta diversity of Salim Ali Bird Sanctuary and its adjacent areas in Thattekkad, Kerala, India

    Directory of Open Access Journals (Sweden)

    A.P. Varghese

    2014-06-01

    Full Text Available Odonata diversity of Salim Ali Bird Sanctuary and its adjacent areas in Thattekkad, Kerala, India were documented from 2010 to 2012. Opportunistic observations were carried out to record species diversity. Eighty-two species of Odonata, which included 51 species of Anisoptera (dragonflies and 31 species of Zygoptera (damselflies, were recorded during the study. Of this 21 species are endemic to the Western Ghats. The presence of the IUCN categorized nearly threatened species like Megalogomphus hannyngtoni and vulnerable species like Platysticta deccanensis and Protosticta sanguinostigma is remarkable.

  14. ALIED: Una teoría de la detección de mentiras

    OpenAIRE

    Street, Chris N. H.

    2016-01-01

    En general, somos torpes a la hora de detectar mentiras y tendemos a creer que los demás dicen la verdad con más frecuencia de la que deberíamos. De hecho, los estudios sobre detección de mentiras suelen describir nuestra tendencia a creer a otras personas como un error de juicio. Aunque parezcamos irremediablemente malos a la hora de detectar mentiras, la teoría del Detector de Mentiras Adaptativo (ALIED) afirma que, en realidad, hacemos juicios inteligentes y bien informados. Este artículo ...

  15. Ab-initio study of phase stability, elastic and thermodynamic properties of AlY alloy under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Dawei [College of Physics and Electronic Engineering, Nanyang Normal University, Nanyang 473061 (China); Su, Taichao [Institute of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000 (China); Song, Haizhen; Lu, Cheng; Zhong, Zhiguo; Lu, Zhiwen [College of Physics and Electronic Engineering, Nanyang Normal University, Nanyang 473061 (China); Pu, Chunying, E-mail: puchunying@126.com [College of Physics and Electronic Engineering, Nanyang Normal University, Nanyang 473061 (China)

    2015-11-05

    Using the particle swarm optimization algorithm combined with first-principles methods, we explore the diagram of AlY alloy up to 250 GPa. It is found that AlDy phase, rather than the experimentally observed B2 phase, is the most stable structure at 0 K and 0–20 GPa. However, our results show that B2 phase can exist as a stable phase at 20–27.6 GPa. At higher pressure, four new high-pressure phases with Cmcm-I, Cmcm-II, I4/mmm and P4/nmm structure are identified for the first time. The hardness, elastic and thermodynamic properties of the newly found phases are investigated and compared with B2 phase. The calculated hardness of AlDy, Cmcm-I, Cmcm-II, I4/mmm and P4/nmm phases is in the range of 7–9 GPa, higher than that of B2 phase. In addition, it is found that AlDy phase is a brittle material at 0 GPa, which changes to a ductile material above 12 GPa. Except for AlDy phase, all the other AlY compounds exhibit completely ductile behavior under pressure. Compared with the other phases, B2 phase is found to have the best ductility and the largest elastic anisotropy over the whole pressure investigated. Moreover, all AlY intermetallics exhibit a nearly elastic isotropy in compressibility but a comparatively large elastic anisotropy in shear. The structural stability, electronic structure, bulk and shear modulus, Debye temperature as well as sound velocities of AlY alloy under pressure are also deeply discussed. - Graphical abstract: Pressure-induced phase transition of AlY alloy up to 250 GPa. - Highlights: • The diagram of AlY alloy was explored and four new stable phases were predicted. • B2 phase shows the largest ductility and elastic anisotropy among AlY alloys. • All AlY alloys exhibit ductile behavior except for AlDy phase under pressure. • All AlY alloys show strong isotropy in compressibility and anisotropy in shear.

  16. Phytochemical screening and In vitro antioxidant activity of Paracalyx scariosa (Roxb Ali

    Directory of Open Access Journals (Sweden)

    RAMOJI ALLA

    2014-06-01

    Full Text Available Paracalyx scariosa (Roxb. Ali. also called as Paracalyx scariosus and cylista scariosa is a woody twiners belongs to the family Fabaceae is one of the important medicinal plant distributed in Central Provinces, West and South India, and Upper Burma. It is woody twiners with tomentose branches and stems finely downy. Leaves are 3-foliate with rhachis prolonged 6-13mm. between the insertion of the leaflets and stipels of the terminal one. The objective of this study is to explore the phytochemistry and the antioxidant potential of various extracts of Paracalyx scariosa (Roxb. Ali which is considered traditionally as an important medicinal plant. The preliminary phytochemical analysis was done to find out the presence of various bioactive compounds and TLC was performed to identify the no of flavonoids present. In vitro antioxidant analysis of methanol, acetone, benzene extracts and ethyl acetate , aqueous fractions of methanol extract was carried out by DPPH assay and Nitric oxide assay. It is observed from the phytochemical study, carbohydrates, proteins, saponins, triterpenoids, flavonoids and alkaloids are present in all the three extracts and Ethyl acetate fraction, benzene extract were separated in to 5 spots identified by bluish black colour confirming the presence of 5 types of flavonoids and the Acetone extract was not separated. Besides the extracts and fractions also possess strong antioxidant activity

  17. Study on nursing of sequential mechanical ventilation treatment of ALI/ARDS%序贯性机械通气治疗ALI/ARDS的护理探讨

    Institute of Scientific and Technical Information of China (English)

    梁梅英; 陈广雪; 梁永祥; 黄富; 韦幼苗; 严文红

    2016-01-01

    ObjectiveTo study the nursing methods of sequential mechanical ventilation in the treatment of acute lung injury and acute respiratory distress syndrome.Methods40 patients with ALI/ARDS,who were treated with sequential mechanical ventilation and were hospitalized in respiratory medicine department of our hospital from June 2014 to August 2015,were selected as the research objects, and were adopted by comprehensive nursing methods of psychological nursing, infection prevention nursing, airway nursing, nasal feeding nursing, grasped the best sequential opportunity of mechanical ventilation.To record the cases of successful offline,the index of blood gas analysis,pH,heart rate,respiratory rate before mechanical ventilation,4h after mechanical ventilation, before tube drawing,4h noninvasive ventilation of patients.Results After sequential mechanical ventilation treatment and nursing on 40 patients,there were 35 cases clinical cured with successful offline,and 5 cases dead.The index of blood gas analysis,pH,heart rate,respiratory rate after mechanical ventilation was better than which before mechanical ventilation,and which in study group was better than which in control group,the differences was statically significant(P<0.05),which 4h after mechanical ventilation was obviously better than which before tube drawing, the differences was statically significant (P<0.05).ConclusionThe effective implementation of positive nursing methods is much important, is basic condition to ensure sequential mechanical ventilation in the treatment of ALI/ARDS,could reduce the VAP incidence, shorten MV time and hospitalization time,reduce patients' hospitalization expenses and economic burden.%目的:探讨序贯性机械通气治疗急性肺损伤/急性呼吸窘迫综合征护理措施。方法选择2014年6月~2015年8月本院呼吸内科住院序贯性机械通气治疗ALI/ARDS患者40例为研究对象,采取心理护理、预防感染护理、气道护理、鼻饲饮食护

  18. Ali Canip Yöntem’in Sanata ve Edebiyata Bakışı Ali Canip Yöntem’s Perspective to Art and Literature

    Directory of Open Access Journals (Sweden)

    Abdullah HARMANCI

    2012-09-01

    Full Text Available Ali Canip Yöntem (1887-1967 who is one of the prominent names of the national literary movement gave many works relating to literary theory and criticism as well as poem. Before being connected to national literary, author who has largely been seeking on the line extending from Muallim Naci to Cedideci (New Literature movement and Fecr-i Aticis (Dawn of the Future has deep thoughts in his many articles that will light the way for today’s artists and researchers either due to hiscommand of our classical literature or of Western Literature. From hiswritings in question, in our article, opinions of Yöntem about somematters such as what is the art and literature, why it is existing, whatcould be its power and effect, how to take advantage of art andliterature, the place and importance of the imitation in art, pleasure,beauty, perception and genius concepts, purpose of art, relationshipbetween artist and school of art, art and dialectic, poem and knowledge,poem and sensation etc were scanned and these opinions were whollyattempted to be assessed. Apart from these, problems collected undersome titles such as what, in fact, is the concept of national literature adhow it should be understood, our mistakes when assessing the concept“national”, dimensions of artist and public when assessing within thecontext of national literature have been the topic of the Ali CanipYöntem’s articles and opinions of author about these issues wereattempted to be examined by us. Yöntem also referred to the problemsabout limits of literary criticism and features which a reviewer musthave, and attached importance to the relationship of literary criticismwith literary text. Milli edebiyat akımının önde gelen isimlerinden olan Ali Canip Yöntem (1887 – 1967, şiirin yanı sıra edebiyat teorisine ve eleştirisine ilişkin eserler de vermiştir. Milli edebiyata mensup olmadan önce, Muallim Naci’den Edebiyatı Cedidecilere, Fecr-i Âticilere uzanan

  19. Plasma CC16 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia: a retrospective observational study

    OpenAIRE

    Lutter Rene; Waddy Sam; Millo Julian L; Determann Rogier M; Garrard Chris S; Schultz Marcus J

    2009-01-01

    Abstract Background Despite consensus criteria, diagnosing acute lung injury, or its more severe form acute respiratory distress syndrome (ALI/ARDS) remains challenging. Adding objective measures, such as plasma levels of biological markers could facilitate recognition of ALI/ARDS. This study was designed to assess and compare the diagnostic accuracy of biological markers for ALI/ARDS with ventilator-associated pneumonia (VAP). Methods We performed serial measurements of Clara cell protein (C...

  20. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

    International Nuclear Information System (INIS)

    One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples. The mRNA levels were measured by quantitative real-time PCR and hybridization of a tumor tissue cDNA array; and the protein levels and distribution by immunostaining of a custom tissue array containing a set of paraffin-embedded samples of different tumor and normal tissues followed by statistical analysis. We show that the expression of two mRNP factors, THOC1 and ALY are altered in several tumor tissues. THOC1 mRNA and protein levels are up-regulated in ovarian and lung tumors and down-regulated in those of testis and skin, whereas ALY is altered in a wide variety of tumors. In contrast to THOC1, ALY protein is highly detected in normal proliferative cells, but poorly in high-grade cancers. These results suggest a differential connection between tumorogenesis and the expression levels of human THO and ALY. This study opens the possibility of defining mRNP biogenesis factors as putative players in cell proliferation that could contribute to tumor development

  1. Arbitražo proceso ypatumai, kai viena iš bylos šalių yra valstybė

    OpenAIRE

    Malinauskaitė, Agnė

    2014-01-01

    Darbe analizuojamas arbitražo procesas, konkretizuojant jį, kai viena iš proceso šalių tampa valstybė. Aptariami esminiai arbitražo, kaip alternatyvaus teismui ginčų sprendimo bruožai tam, kad suvokti paties proceso prigimtį. Gilinamasi į procedūrinius skirtumus, kai atsiranda valstybinė dalyvaujančioji šalis. Aptariamas Lietuvos ir kitų valstybių teisinis reglamentavimas, susijęs su valstybės dalyvavimu arbitražiniame susitarime ir arbitražo procese. Aktualus arbitruotinumo klausimas, su tuo...

  2. Reconnectionless CME eruption: putting the Aly-Sturrock conjecture to rest

    CERN Document Server

    Rachmeler, L A; Kankelborg, C C

    2008-01-01

    We demonstrate that magnetic reconnection is not necessary to initiate fast CMEs. The Aly-Sturrock conjecture states that the magnetic energy of a given force free boundary field is maximized when the field is open. This is problematic for CME initiation because it leaves little or no magnetic energy to drive the eruption, unless reconnection is present to allow some of the field to escape without opening. Thus, it has been thought that reconnection must be present to initiate CMEs. This theory has not been subject to rigorous numerical testing because conventional MHD numerical models contain numerical diffusion, which introduces uncontrolled numerical reconnection. We use a quasi-Lagrangian simulation technique to run the first controlled experiments of CME initiation in the complete lack of reconnection. We find that a flux rope confined by an arcade, when twisted beyond a critical amount, can escape to an open state, allowing some of the surrounding arcade to shrink and releasing magnetic energy from the ...

  3. FAMoS - an information service on the usage of data files in AliEn

    Science.gov (United States)

    Abramyan, A.; Betev, L.; Buncic, P.; Grigoras, C.; Grigoryan, A.; Manukyan, N.; Pedreira, M. M.; Saiz, P.

    2015-05-01

    The File Access Monitoring Service (FAMoS) leverages the information stored in the central AliEn file catalogue, which describes every file in a Unix-like directory structure, as well as metadata on file location and its replicas. In addition, it uses the access information provided by a set of API servers, used by all Grid clients to access the catalogue. The main functions of FAMoS are to sort the file accesses by logical groups, access time, user and storage element. The collected data identifies rarely used groups of files, as well as those with high popularity over different time periods. This information can be further used to optimize file distribution and replication factors, thus increasing the data processing efficiency. The paper describes the FAMoS structure and user interface and presents the results obtained in one year of service operation.

  4. Lietuvos interneto žiniasklaidos vaidmuo formuojant šalies įvaizdį

    OpenAIRE

    Pilinkaitė, Miglė

    2014-01-01

    Magistro darbo objektas – interneto žiniasklaida kaip viena iš priemonių, padedančių valstybei kurti įvaizdį bei taip siekti užsibrėžtų tikslų ir interesų tiek tarptautiniu, tiek nacionaliniu mastu. Interneto žiniasklaida darbe apjungia tris priemones: naujienų portalus, dienraščių interneto portalus bei interneto dienoraščius. Darbo tikslas – išnagrinėti Lietuvos interneto žiniasklaidos vaidmenį šalies įvaizdžio formavimo procese. Rengiant darbą buvo iškelti tokie pagrindiniai uždaviniai: ap...

  5. The DUB-ious lack of ALIS in Salmonella infection: a Salmonella deubiquitinase regulates the autophagy of protein aggregates.

    Science.gov (United States)

    Thomas, Mair; Mesquita, Francisco S; Holden, David W

    2012-12-01

    Ubiquitinated aggregates are formed in eukaryotic cells in response to several external stimuli, including exposure to bacterial lipopolysaccharide (LPS). Although Salmonella enterica serovar Typhimurium (S. Typhimurium) LPS has been shown to induce aggresome-like induced structures (ALIS) in macrophages, these have not been described in S. Typhimurium-infected macrophages. Given that LPS is present in infection, this suggests that S. Typhimurium might suppress the formation of ALIS. We found that S. Typhimurium induces the formation of ubiquitinated aggregates in epithelial cells and macrophages, but that their presence is masked by the deubiquitinase (DUB) activity of the S. Typhimurium virulence protein, SseL. SseL deubiquitinates SQSTM1/p62-bound proteins found in S. Typhimurium-induced aggregates and ALIS, and reduces the recruitment of autophagic components. While the functions of ALIS and other ubiquitinated aggregates remain unclear, they serve to sequester cytosolic proteins under a variety of stress conditions and are suggested to be involved in host immune defense. During infection, the deubiquitinase activity of SseL reduces autophagic flux in infected cells and favors bacterial replication. This is a new example of how a bacterial pathogen counteracts the autophagy pathway through the action of a translocated virulence protein.

  6. De IPR-bepalingen in de ALI/UNIDROIT Principles of transnational civil procedure. : Een bruikbaar model voor harmonisatie?

    NARCIS (Netherlands)

    X.E. Kramer (Xandra)

    2009-01-01

    textabstractIn deze bijdrage worden de nog weinig onderzochte bepalingen van de ALI/UNIDROIT Principles of transnational civil procedure bekeken die relevant zijn voor het internationaal privaatrecht. Deze Principles worden afgezet tegen bestaande internationale en Nederlandse IPR-regels. Voorts wor

  7. The Relation of UCCE and Politics in the Period of Ali Coşkun's Presidential Term at UCCE

    Directory of Open Access Journals (Sweden)

    Hüseyin ÇAVUŞOĞLU

    2011-06-01

    Full Text Available One can see that during the period between establishment of Turkish Union of Chambers and Exchange Commodities (TOBB (6 February 1952 and Mehmet Yazar’s presidency of Turkish Union of Chambers (27 May 1979 Democratic Party and Justice Party dominated the Union of Chambers. During Mehmet Yazar’s presidency period of TOBB (27 May 1979 – 4 April 1985 relationship between TOBB and Mother Land Party (ANAP became problematic, and in contrast to the previous periods the TOBB became an independent foundation and gained significant contributions in being a group of interest and reached a substantial economical power. In Ali Coskun’s presidency period of TOBB (4 June 1986 – 30 May 1990, on the other hand, one might see that ANAP dominated the TOBB, and TOBB lost its independence and couldn’t make significant proceedings in being a group of interest. In the same period, ANAP government made steps in direction of requests from the TOBB. As in the previous periods, during Ali Coskun’s presidency period a lot of people entered policy from the central-right parties (ANAP and True Path Party, DYP. Aim of the present study was to discuss the relationship between political power and Union of Chambers during Ali Coskun’s presidency period of TOBB and Ali Coskun’s presidency period’s differences from and similarities with the previous periods.

  8. The Ali Rajas of Cannanore : status and identity at the interface of commercial and political expansion, 1663-1723

    NARCIS (Netherlands)

    John, Binu Mailaparambil

    2007-01-01

    The present study focuses on the Mappila Muslim trading elites in the port city of Cannanore, particularly the Arackal Ali Rajas, on the south-west coast of India and their response to the shifting power relations in the region brought about by the changes in the Indian Ocean maritime trade scenario

  9. Identification of Antifungal Substances of Lactobacillus sakei subsp. ALI033 and Antifungal Activity against Penicillium brevicompactum Strain FI02.

    Science.gov (United States)

    Huh, Chang Ki; Hwang, Tae Yean

    2016-03-01

    This study was performed to investigate the antifungal substances and the antifungal activity against fungi of lactic acid bacteria (LAB) isolated from kimchi. LAB from kimchi in Imsil showed antifungal activity against Penicillium brevicompactum strain FI02. LAB LI031 was identified as Lactobacillus sakei subsp. Antifungal substances contained in L. sakei subsp. ALI033 culture media were unstable at high pH levels. Both, the control and proteinase K and protease treated samples showed clear zones, suggesting that the antifungal substances produced by ALI033 were non-protein substances unaffected by protesases. Both, the control and catalase showed clear zones, suggesting that the antifungal metabolite was not H2O2. The molecular weights of the antifungal substances were ≤3,000 Da. The organic acid content of crude antifungal substances produced by L. sakei subsp. ALI033 showed high concentrations of lactic acid (502.47 mg/100 g). Therefore, these results suggest that antifungal substance produced by L. sakei subsp. ALI033 is most likely due to its ability in producing organic acid. PMID:27069906

  10. Mir Masoom Ali: A Distinguished and Dedicated Statistician Who Never Gets Old – Even at Seventy-Five

    Directory of Open Access Journals (Sweden)

    Aylin Alin

    2012-07-01

    Full Text Available I first met Distinguished Professor Dr. Mir Masoom Ali at the International Conference on Mathematics and Statistics held in Athens, Greece in 2007. He was there as an invited speaker and he also chaired my session. After my session we had a chance to chat on our way to the restaurant where the banquet was held.  Even though it was the first time we hadmet, he was very kind to me.  He was there with his wife Firoza (Leena Ali. They looked great together.  Family is the most important part of our lives.  It was immediately apparent to me that Professor Ali, apart from being an outstanding statistician and a great teacher, is also a dedicated husband, father and grandfather. We have always kept in touch since our first meeting. I am very lucky to have had a chance to recently collaborate with him in a research paper. It is also a great honor for me to have been asked to serve as a guest editor for this special issue and to be able to be part of this undertaking to celebrate Dr. Ali’s 75th birthday anniversary. To some people, age is only an indicator of the year they were born but inside they feel much younger. Professor Ali is onesuch person who not only looks very young both physically and emotionally for his age but who also has the personality and mentality of a very active younger person. That is why I have chosen the title "Mir Masoom Ali: A Distinguished and Dedicated Statistician Who Never Gets Old - Even at Seventy-Five."  

  11. Effet des conditions climatiques sur le niveau du lac Sidi Ali (Moyen Atlas, Maroc

    Directory of Open Access Journals (Sweden)

    Claude Martin

    2011-11-01

    Full Text Available Le lac Sidi Ali est un lac naturel d'altitude (2070-2080 m, sans exutoire superficiel, déterminé par le barrage d'une coulée basaltique. Doté d'un bassin versant apparent de 15,6 km2, il est alimenté par des eaux de ruissellement et par des sources karstiques. Son niveau subit des variations très fortes, annuelles et interannuelles, sous le contrôle des conditions climatiques, et en particulier des pluies et de l'évapotranspiration. Les périodes de sécheresse qui ont marqué les trois dernières décennies, se sont traduites par un abaissement du niveau de près de 7 m. Mais les précipitations abondantes des années 2008-09 et 2009-10 ont provoqué une nette remontée. Une régression multiple d'assez bonne qualité (r = 0,87 lie la variation annuelle du niveau (d'août à août à différents paramètres (conditions climatiques et niveau initial du lac.Lake Sidi Ali is a natural lake at high altitude (2070-2080 m, without surface outlet, determined by the dam of a basalt flow. With an apparent catchment of 15.6 km2, it is fed by runoff and karst springs. Its level shows strong annual and interannual variations, depending on weather conditions, particularly rainfall and evapotranspiration. Droughts that have marked the last three decades have resulted in a lowering of about 7 m of the water level. But heavy rainfall that occurred in 2008-09 and 2009-10 caused a marked rise. A multiple regression of sufficient quality (r = 0.87 binds the annual change (from august to august at differents parameters (weather conditions and initial level of the lake.

  12. Lithospheric mantle evolution in the Afro-Arabian domain: Insights from Bir Ali mantle xenoliths (Yemen)

    Science.gov (United States)

    Sgualdo, P.; Aviado, K.; Beccaluva, L.; Bianchini, G.; Blichert-Toft, J.; Bryce, J. G.; Graham, D. W.; Natali, C.; Siena, F.

    2015-05-01

    Detailed petrological and geochemical investigations of an extensive sampling of mantle xenoliths from the Neogene-Quaternary Bir Ali diatreme (southern Yemen) indicate that the underlying lithospheric mantle consists predominantly of medium- to fine-grained (often foliated) spinel-peridotites (85-90%) and spinel-pyroxenites (10-15%) showing thermobarometric estimates in the P-T range of 0.9-2.0 GPa and 900-1150 °C. Peridotites, including lherzolites, harzburgites and dunites delineate continuous chemical, modal and mineralogical variations compatible with large extractions of basic melts occurring since the late Proterozoic (~ 2 Ga, according to Lu-Hf model ages). Pyroxenites may represent intrusions of subalkaline basic melts interacting and equilibrated with the host peridotite. Subsequent metasomatism has led to modal changes, with evidence of reaction patches and clinopyroxene and spinel destabilization, as well as formation of new phases (glass, amphibole and feldspar). These changes are accompanied by enrichment of the most incompatible elements and isotopic compositions. 143Nd/144Nd ranges from 0.51419 to 0.51209 (εNd from + 30.3 to - 10.5), 176Hf/177Hf from 0.28459 to 0.28239 (εHf from + 64.4 to - 13.6), and 208Pb/204Pb from 36.85 to 41.56, thus extending from the depleted mantle (DM) towards the enriched OIB mantle (EM and HIMU) components. 3He/4He (R/RA) ratios vary from 7.2 to 7.9 with He concentrations co-varying with the most incompatible element enrichment, in parallel with metasomatic effects. These metasomatic events, particularly effective in harzburgites and dunites, are attributable to the variable interaction with alkaline basic melts related to the general extensional and rifting regime affecting the East Africa-Arabian domain during the Cenozoic. In this respect, Bir Ali mantle xenoliths resemble those occurring along the Arabian margins and the East Africa Rift system, similarly affected by alkaline metasomatism, whereas they are

  13. Experimental study on influence of Tongfu Xiefei therapy on immune inflammatory damage in ALI/ARDS Rats%通腑泻肺法对ALI/ARDS大鼠免疫炎症损伤影响的实验研究

    Institute of Scientific and Technical Information of China (English)

    刘恩顺; 苏景深; 孙增涛; 付敏; 封继宏

    2011-01-01

    [Objective] To observe the effect of Tongfu Xiefei therapy on the immune inflammatory damage in ALI/ARDS rats and to investigate the biological basis of the interior-exteriorly related theory of lung and the large intestine. [Methods] The health Wistar rats were divided the health Wistar rats into 5 groups: control group, model group, lung treatment group, large intestine treatment group and lung-large intestine treatment group. The ALI/ARDS in rats was established by intravenous injecting oleic acid plus endotoxin in caudal vein, and the D-Lactate, DAO, TNF-α, IL-1β, IL-6, IL-10 in blood, sIgA in lung and large intestine were observed. [Results] Tongfu Xiefei therapy could effectively reduce the expression of systemic inflammatory factors in rats, such as TNF-α, IL-1β, IL-6, IL-10; and reduced the D-Lactate, DAO and sIgA in lung and large intestine organs. [Conclusion] l)Tongfu Xiefei therapy can effectively reduce the immune inflammation and the intestinal mucosal barrier injury in rats with ALI/ARDS. The combined method is superior than either single method of Xiefei therapy or Tongfu therapy; 2)The action targets of Xiefei therapy, Tongfu therapy and Tongfu Xiefei therapy on inflammatory factors in ALI/ARDS rats are different, and the mechanism may be related with inhibiting the synthesis and secretion of inflammatory factors and regulating the immune function of the intestines.%[目的]观察通腑泻肺法对急性肺损伤(ALI)急性呼吸窘迫综合征(ARDS)大鼠免疫炎症损伤的影响,探讨肺与大肠相表里理论的生物学基础.[方法]将健康wistar大鼠随机分为5组,正常对照组、模型组、治肺组、治肠组和肺肠同治组,采用尾静脉注射油酸加内毒素方法造成大鼠ALI/ARDS模型,观察大鼠血中D-乳酸、丙二醛(DAO)、肿瘤坏死因子-α(TNF-α)、白介素IL-Iβ(IL-Iβ)、白介素-6(IL一6)、白介素一10(IL-IO)及肺、肠组织分泌型免疫球蛋白A(slgA)含量.[结果]通腑泻肺法可

  14. The Effect of Dramatized Instruction on Speaking Ability of Imam Ali University EFL Learners

    Directory of Open Access Journals (Sweden)

    Sadegh Khosronejad

    2013-09-01

    Full Text Available Teaching language as a second or foreign language, undoubtedly, is so demanding and seeking to find methods for facilitating this prominent practice whets the appetite of any practitioner who works in this field. Research shows that using drama in the classroom as a means of teaching helps students learn socially, academically, and developmentally. This study was an attempt to determine the effect of dramatized instruction on the speaking ability of EFL learners of Imam Ali University. Sixty EFL male students at the intermediate level participated in the study. Their age range was 19-22. Two instruments were utilized in this study; pretest, and posttest.  The data were analyzed through t-test. The data analysis indicated that the mean scores of the experimental group students (M = 72.80 were significantly different (3.29>2; df = 58 from the control group students (M = 65.39. In other words, the experimental group outperformed the control group in the posttest significantly. Moreover, the findings indicated that dramatized instruction does have a great effect on the speaking skills. This study supported the idea of effectiveness of dramatized instruction on developing speaking skill and the teachers can help the learners at lower levels promote their speaking skill through dramatized instruction in EFL classes.Key words: Drama, Dramatized Instruction, Conventional Methods

  15. A Review of Ferdous al-Hekma fil-Tibb by Ali ibn Raban Tabari.

    Science.gov (United States)

    Ardalan, Mohammadreza; Khodadoust, Kazem; Mostafidi, Elmira

    2015-01-01

    T Ferdous al-Hekma (Paradise of Wisdom) is one of the oldest medical texts in the Islamic world written in Arabic in 850 AD by Ali ibn Raban Tabari. He was a Persian physician who moved from Tabaristan (Mazandaran province of modern day Iran) to Samarra during the reign of the Abbasid Caliph al-Mutawakkil (847-861 AD). We studied the book of Ferdous al-Hekma fil-Tibb, in an attempt to comprehend its general outlook on diseases of different organs, their classifications and the associated signs and symptoms. The book is one of the earliest medical pandects of the period of translation, adaptation and expansion of knowledge in the Islamic world during the 9(th) century AD. Tabari was mainly influenced by Hippocrates, Galen and Aristotle, as well as his contemporaries Johanna ibn Massavieh and Hunayn ibn Ishaq. The book is written in thirty chapters in a total number of 308 subtitles. In each part there is an introduction to the symptomatology, followed by organ specific diseases and therapeutic recommendations. Symptoms and physical signs of different diseases are vividly described in Ferdous al-Hekma, and some of them are even understandable for contemporary medical students. PMID:27350863

  16. Greater self-enhancement in Western than Eastern Ukraine, but failure to replicate the Muhammad Ali effect.

    Science.gov (United States)

    Kemmelmeier, Markus; Malanchuk, Oksana

    2016-02-01

    Based on the cross-cultural research linking individualism-collectivism and self-enhancement, this research examines regional pattern of self-enhancement in Ukraine. Broadly speaking, the western part of Ukraine is mainly Ukrainian speaking and historically oriented towards Europe, whereas Eastern Ukraine is mainly Russian speaking and historically oriented towards the Russian cultural sphere. We found self-enhancement on a "better than average" task to be higher in a Western Ukrainian sample compared to an Eastern Ukrainian sample, with differences in independent self-construals supporting assumed regional variation in individualism. However, the Muhammad Ali effect, the finding that self-enhancement is greater in the domain of morality than intelligence, was not replicated. The discussion focuses on the specific sources of this regional difference in self-enhancement, and reasons for why the Muhammad Ali effect was not found.

  17. Greater self-enhancement in Western than Eastern Ukraine, but failure to replicate the Muhammad Ali effect.

    Science.gov (United States)

    Kemmelmeier, Markus; Malanchuk, Oksana

    2016-02-01

    Based on the cross-cultural research linking individualism-collectivism and self-enhancement, this research examines regional pattern of self-enhancement in Ukraine. Broadly speaking, the western part of Ukraine is mainly Ukrainian speaking and historically oriented towards Europe, whereas Eastern Ukraine is mainly Russian speaking and historically oriented towards the Russian cultural sphere. We found self-enhancement on a "better than average" task to be higher in a Western Ukrainian sample compared to an Eastern Ukrainian sample, with differences in independent self-construals supporting assumed regional variation in individualism. However, the Muhammad Ali effect, the finding that self-enhancement is greater in the domain of morality than intelligence, was not replicated. The discussion focuses on the specific sources of this regional difference in self-enhancement, and reasons for why the Muhammad Ali effect was not found. PMID:25684090

  18. Said Ali e a acentuação: primórdios da Linguística no Brasil

    Directory of Open Access Journals (Sweden)

    Maria Mercedes Saraiva Hackerott

    2011-01-01

    Full Text Available Since his first articles in Revista Brazileira published in 1895, Manuel Said Ali Ida (1860-1953 gave priority to the synchronic study of the spoken language. He argues that dynamic accent (greater voice intensity and musical accent (pitch affect the meaning of the clause and demonstrate the interdependence of the phonetic, syntactic and semantic levels. In Portuguese, the word pronounced with most stress contains the main idea and is usually placed at the end of the clause. A change of word order or stress replacement draws the listener’s attention and facilitates the identification of new information by means of intonation. The introduction of phonetic criteria as a parameter of analysis separates Said Ali from the grammatical tradition of his time, making him the precursor of Brazilian linguistics. This essay in Linguistic Historiography seeks to trace in Said Ali’s work on accent the emergence of a new field of language study.

  19. ALICE distributed analysis of the K*(892)0 signal in pp events with the AliEn package

    International Nuclear Information System (INIS)

    A simulation study concerning the K*(892)0 resonance was carried out within the ALICE Collaboration, in order to evaluate the capability of the detector in the reconstruction of this signal in pp collisions at the Large Hadron Collider (LHC) energy. A description of the analysis procedure which makes use of AliEn, the ALICE package for distributed computing, is given together with the obtained results

  20. Identification of Antifungal Substances of Lactobacillus sakei subsp. ALI033 and Antifungal Activity against Penicillium brevicompactum Strain FI02

    OpenAIRE

    Huh, Chang Ki; Hwang, Tae Yean

    2016-01-01

    This study was performed to investigate the antifungal substances and the antifungal activity against fungi of lactic acid bacteria (LAB) isolated from kimchi. LAB from kimchi in Imsil showed antifungal activity against Penicillium brevicompactum strain FI02. LAB LI031 was identified as Lactobacillus sakei subsp. Antifungal substances contained in L. sakei subsp. ALI033 culture media were unstable at high pH levels. Both, the control and proteinase K and protease treated samples showed clear ...

  1. JAliEn – A new interface between the AliEn jobs and the central services

    International Nuclear Information System (INIS)

    Since the ALICE experiment began data taking in early 2010, the amount of end user jobs on the AliEn Grid has increased significantly. Presently 1/3 of the 40K CPU cores available to ALICE are occupied by jobs submitted by about 400 distinct users, individually or in organized analysis trains. The overall stability of the AliEn middleware has been excellent throughout the 3 years of running, but the massive amount of end-user analysis and its specific requirements and load has revealed few components which can be improved. One of them is the interface between users and central AliEn services (catalogue, job submission system) which we are currently re-implementing in Java. The interface provides persistent connection with enhanced data and job submission authenticity. In this paper we will describe the architecture of the new interface, the ROOT binding which enables the use of a single interface in addition to the standard UNIX-like access shell and the new security-related features

  2. EXAMINING ASGHAR ALI ENGINEER'S QUR'ANIC INTERPRETATION OF WOMEN IN ISLAM

    Directory of Open Access Journals (Sweden)

    M. Agus Nuryatno

    2007-08-01

    Full Text Available This article discusses Asghar Ali Engineer’s interpretation of women in Islam. Two topics discussed in this article are the status of women in Islam and the veil. Engineer offers an approach in understanding the Qur’an to deal with these topics and his method is based on three principles: firstly, the Qur’an has two ingredients: normative and contextual. Normative ingredient refers to the fundamental values and principles of Qur’an such as equality and justice, and these principles are eternal and can be applied in various social contexts. Contextual revelations, on the other hand, deal with verses that were tailored to socio-historical problems of the time. In line with the changes in context and time these verses can be abrogated. Secondly, the interpretation of the Qur’anic verses is very dependent on one’s own perceptions, world-view, experiences and the sociocultural background in which he/she lives. Thus, a ‘pure’ interpretation of the Scripture is not possible; it is always influenced by sociological circumstances, no one can be free of such influences. Thirdly, the meaning of the Qur’anic verses unfolds with time, therefore, the interpretations of classical scholars can be radically different from the interpretation of modern scholars. This is because Qur’anic verses often use symbolic or metaphorical language that is ambiguous in meaning. This ambiguity serves, of course, to promote flexibility and creative change. These three principles can be employed to understand the status of women in Islam and the veil.

  3. A study of fine structure of diffuse aurora with ALIS-FAST measurements

    Directory of Open Access Journals (Sweden)

    T. Sergienko

    2008-10-01

    Full Text Available We present results of an investigation of the fine structure of the night sector diffuse auroral zone, observed simultaneously with optical instruments (ALIS from the ground and the FAST electron spectrometer from space 16 February 1997. Both the optical and particle data show that the diffuse auroral zone consisted of two regions. The equatorward part of the diffuse aurora was occupied by a pattern of regular, parallel auroral stripes. The auroral stripes were significantly brighter than the background luminosity, had widths of approximately 5 km and moved southward with a velocity of about 100 m/s. The second region, located between the region with auroral stripes and the discrete auroral arcs to the north, was filled with weak and almost homogeneous luminosity, against which short-lived auroral rays and small patches appeared chaotically. From analysis of the electron differential fluxes corresponding to the different regions of the diffuse aurora and based on existing theories of the scattering process we conclude the following: Strong pitch angle diffusion by electron cyclotron harmonic waves (ECH of plasma sheet electrons in the energy range from a few hundred eV to 3–4 keV was responsible for the electron precipitation, that produced the background luminosity within the whole diffuse zone. The fine structure, represented by the auroral stripes, was created by precipitation of electrons above 3–4 keV as a result of pitch angle diffusion into the loss cone by whistler mode waves. A so called "internal gravity wave" (Safargaleev and Maltsev, 1986 may explain the formation of the regular spatial pattern formed by the auroral stripes in the equatorward part of the diffuse auroral zone.

  4. Islam dan Pemberontakan terhadap Status Quo: Telaah atas Pemikiran teologi Sosial Ali Syariati

    Directory of Open Access Journals (Sweden)

    Mukhlis Mukhlis

    2015-12-01

    Full Text Available Ali Syariati, a Syiah moslem intellectual and a doctor in sociology of Islam, has written books and articles that are inspired by his Islamic internalization as a Syiah moslem. This article, through social theological perpective, is aimed at grasping sociological ideas of Syariati’s by tracing its theological and philosophical basis and his world view. It is found that his ideas are more an expression of islamic thought which are articulated in sociological terms. His ideas aimed to break the opressor-oppressed relation of Iran people at his time. The spirit of his ideas is to vanish the first and, then, awaken the second so that they are able to quit of the shackle of oppression. Those are responsible to do such a hard duty are rûshanfekr, enlightened intellectual. Qs. 28:5 and Qs. 30:1-4 and 30 are among al-Qur’an verses that inspired him and became theological arm rest of his ideas. 

  5. Geochemical and mineralogical features of the polymetallic deposit from Ali' (NE Sicily, Italy

    Directory of Open Access Journals (Sweden)

    D'Urso, D

    2007-04-01

    Full Text Available The mineralization processes in the Peloritani Belt (Southern Sector of the Calabria- Peloritani Arc, related to Pre-Variscan intracontinental rifting, produced sedex-type Pb, Zn, F (Ag, Cu, W (As, Sb ores. This paper focuses on the metalliferous stratabound mineralization outcropping in the Ali' area (Tripi locality. It is part of sulphide ores, concordant with the regional foliation of the hosting unit (Fv2, very widespread in the Mandanici Unit (MaU. This unit is characterized by a Variscan low-P, polyphasic and plurifacial metamorphic overprint involving the basement. This metamorphic overprint exhibits a prograde zoning, from a chlorite zone of greenschist facies to an oligoclase-almandine zone of amphibolite facies. The metalliferous mineral association is formed by galena, sphalerite, pyrite, chalcopyrite, arsenopyrite and covellite. Quartz and fluorite among non-metalliferous minerals are predominant. Some minerals like quartz, fluorite, galena, sphalerite and pyrite are present in two generations, the second of which can be related to intense hydrothermal activity involving the whole Peloritani Belt. Trace-element contents of sulphide ores detected by Atomic Absorption and Inductively Coupled Plasma-Mass Spectrometry on powdered and selected samples of minerals have been determined. Major elements have been analyzed by Scanning Electron Microscopy. The Ag content is quite high in galena, relative to the same mineral of other Peloritani deposits in which this content is around 1000 ppm. Galena shows a high content of Sb (x=621 and lower values of Cd (x=132 and Cu (x=108 whereas in sphalerite the Sb content (x=134 is lower than Cd (x=1118 and Cu (x=1127. Mn is scarcely present in sphalerite, while galena shows higher contents. Fe content in sphalerite is about 6%, in agreement with Pressure-Temperature conditions of the Unit.

  6. Alteration zone Mapping in the Meiduk and Sar Cheshmeh Porphyry Copper Mining Districts of Iran using Advanced Land Imager (ALI Satellite Data

    Directory of Open Access Journals (Sweden)

    A. Beiranvand Pour

    2015-10-01

    Full Text Available This study evaluates the capability of Earth Observing-1 (EO1 Advanced Land Imager (ALI data for hydrothermal alteration mapping in the Meiduk and Sar Cheshmeh porphyry copper mining districts, SE Iran. Feature-oriented principal components selection, 4/2, 8/9, 5/4 band ratioing were applied to ALI data for enhancing the hydrothermally altered rocks associated with porphyry copper mineralization, lithological units and vegetation. Mixture-tuned matched-filtering (MTMF was tested to discriminate the hydrothermal alteration areas of porphyry copper mineralization from surrounding environment using the shortwave infrared bands of ALI. Results indicate that the tested methods are able to yield spectral information for identifying vegetation, iron oxide/hydroxide and clay minerals, lithological units and the discrimination of hydrothermally altered rocks from unaltered rocks using ALI data.

  7. Plasma CC16 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia: a retrospective observational study

    Directory of Open Access Journals (Sweden)

    Lutter Rene

    2009-12-01

    Full Text Available Abstract Background Despite consensus criteria, diagnosing acute lung injury, or its more severe form acute respiratory distress syndrome (ALI/ARDS remains challenging. Adding objective measures, such as plasma levels of biological markers could facilitate recognition of ALI/ARDS. This study was designed to assess and compare the diagnostic accuracy of biological markers for ALI/ARDS with ventilator-associated pneumonia (VAP. Methods We performed serial measurements of Clara cell protein (CC16, soluble receptor for advanced glycation end products (sRAGE, surfactant protein D (SP-D and Krebs von den Lungen (KL-6 in plasma of patients with VAP and mechanically ventilated control patients without VAP. ALI/ARDS was diagnosed using the criteria of the North-American European consensus conference. Results Thirty-seven patients were enrolled - 22 patients with VAP and 15 control patients. Ten patients with pneumonia met the ALI/ARDS consensus criteria. Control patients never met these criteria. Plasma CC16 had a good diagnostic capacity for ALI/ARDS as shown by the receiver operating characteristic curve with an area under the curve of 0.91 (95% confidence interval (CI 0.79 - 1.00; p p = 0.02. The diagnostic accuracies of KL-6 and sRAGE were low. Conclusion Plasma CC16 seems a potential biological marker for ALI/ARDS in patients with VAP. Plasma levels of sRAGE, SP-D and KL-6 have limited discriminative power for diagnosing ALI/ARDS in VAP.

  8. 75 FR 2921 - In the Matter of the Designation of Said Ali al-Shihri, Also Known as Abu-Sayyaf, Also Known as...

    Science.gov (United States)

    2010-01-19

    ... Matter of the Designation of Said Ali al-Shihri, Also Known as Abu-Sayyaf, Also Known as Abu-Sufyan al-Azidi, Also Known as Abu-Sayyaf al-Shihri, Also Known as Abu Sufian Kadhdhaab Matrook, Also Known as Sa'id Ali Jabir al-Khathim al-Shihri, Also Known as Salad, Also Known as Abu Salah Abu Sufyan,...

  9. Mineral mapping on the Chilean-Bolivian Altiplano using co-orbital ALI, ASTER and Hyperion imagery: Data dimensionality issues and solutions

    Science.gov (United States)

    Hubbard, B.E.; Crowley, J.K.

    2005-01-01

    Hyperspectral data coverage from the EO-1 Hyperion sensor was useful for calibrating Advanced Land Imager (ALI) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) images of a volcanic terrane area of the Chilean-Bolivian Altiplano. Following calibration, the ALI and ASTER datasets were co-registered and joined to produce a 13-channel reflectance cube spanning the Visible to Short Wave Infrared (0.4-2.4 ??m). Eigen analysis and comparison of the Hyperion data with the ALI + ASTER reflectance data, as well as mapping results using various ALI+ASTER data subsets, provided insights into the information dimensionality of all the data. In particular, high spectral resolution, low signal-to-noise Hyperion data were only marginally better for mineral mapping than the merged 13-channel, low spectral resolution, high signal-to-noise ALI + ASTER dataset. Neither the Hyperion nor the combined ALI + ASTER datasets had sufficient information dimensionality for mapping the diverse range of surface materials exposed on the Altiplano. However, it is possible to optimize the use of the multispectral data for mineral-mapping purposes by careful data subsetting, and by employing other appropriate image-processing strategies.

  10. Incorporation of Tongkat Ali and Ginseng extracts from mass propagated roots derived from bioreactor technology as supplements in energy chocolate confectionery

    International Nuclear Information System (INIS)

    Tongkat Ali (Eurycoma longifolia) and Ginseng (Panax ginseng) are well known herbs among Asians and have been sought after by Europeans and others for the benefits to health, especially as aphrodisiac and nourishing stimulants. They have high antioxidant level and were reported to be used in the treatment of type II diabetes, as well as for sexual dysfunction in men. Since Tongkat Ali and Ginseng are difficult to cultivate and have a long cultivation period, the bioreactor technology is the alternative method to produce huge amount of raw materials for the herbal industry and continuous supply of standardized raw materials that is not affected by geographical and environmental factors, soil less and free from pesticides and other contaminants. Tongkat Ali and Ginseng extracts from mass propagated roots derived from bioreactor technology have similar profiles as extracts derived from normal cultivation. Liquid Chromatography-Mass Spectrometer (LC-MS) profiles showed presence of active compounds in the Tongkat Ali and Ginseng extracts from the mass propagated roots. Cytotoxicity test using the brine shrimp (Artemia salina Leach) lethality assay, revealed that higher concentration of Tongkat Ali and Ginseng extracts from mass propagated roots did not kill or affect the brine shrimps, implying that the extracts were safe for consumption. Incorporation of combination of Tongkat Ali and Ginseng total extracts from mass propagated roots derived from bioreactor technology energy chocolate confectionery was accepted by the panelists in sensory evaluation and showed that the chocolate product has good potential as a carrier besides beverages and capsules. (author)

  11. 血浆vWF:Ag、蛋白C活性在ALI/ARDS患者诊断和预后中的意义%Evaluation of Plasma vWF : Ag and Protein C Activity in the Diagnosis and Prognosis of Patients at Risk of ALI/ARDS

    Institute of Scientific and Technical Information of China (English)

    夏炎火; 林锡芳; 潘景业; 王丹; 李卓英; 杨梅

    2013-01-01

    Objective To evaluate the value and feasibility of plasma vWF: Ag and protein C activity in the diagnosis and prognosis in ALI/ARDS patients. Methods The clinical data of 49 ALI/ARDS patients and 21 non - ALI / ARDS patients was collected and evaluated with APACHE II score system and lung injury score(LIS). Furthermore, ALI/ARDS patients were divided into two groups by prognosis, etiology, and organ failure number ( nonpulmonary). Mortality of every group was collected. Plasma vWF:Ag and protein C activity of patients were detected and evaluated. The value of plasma vWF:Ag and protein C activity in diagnosis of ALI/ARDS was analyzed by receiver operator characteristic( ROC) curve. Results Compared with non - ALI/ARDS group, the mortality and LIS score of ALI/ARDS group were significantly increased, PaO2/FiO2 was significantly declined. Plasma vWF: Ag (104% -752% ) in ALI / ARDS group was higher (P = 0.026), but PC activity ( 14% -125%) was significantly lower (P =0. 002). In the ALI/ARDS patients, plasma vWF: Ag of dead group, infected group and 3: 2 organ failure group were significantly higher than their control group; while PC activity of the three groups were greatly lower than their control groups. ROC curve analysis showed that PC activity was better in prediction ALI/ARDS (AUC = 0.709,95% CI:0.588 -0. 811 ,P =0. 0016) ,and the sensitivity and specificity were respectively 77. 75% and 57. 14% when PC activity ≤83% ; but vWF: Ag was poor in prediction ALI/ARDS ( AUC =0. 584,95% CI:0. 460-0. 701, P=0.2426). Conclusion Elevated plasma vWF;Ag and declined PC activity are associated with an increased risk of death and worse prognosis in ALI/ARDS patients. The accuracy of plasma PC activity to predict ALI/ARDS was better, but it is a controversial conclusion in prediction ALI/ARDS by plasma vWF:Ag.%目的 探讨血浆血管性血友病因子抗原(vWF:Ag)、蛋白C(PC)活性在急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)患者早期诊断

  12. Mohammed Ali, ʿƎmanini (“Trust me”): Linguistic features of a novel in Tigre

    OpenAIRE

    Lusini, Gianfrancesco

    2012-01-01

    The novel ʿƎmanini (“Trust me”) by Mohammed Ali Ibrahim Mohammed (born 1966) is the first work written in Tigre by a native speaker. This is a true literary and linguistic experiment, which will greatly enrich our knowledge of the Tǝgrāyǝt grammar and vocabulary, specifically its little known variant spoken among the Beni ʿAmǝr. Several phonetic, morphological, syntactical and lexical peculiarities of the text are here examined in order to reveal whether they are dictated by linguistic constr...

  13. Birds of the Sálim Ali Centre for Ornithology and Natural History Campus, Anaikatty Hills, southern India

    Directory of Open Access Journals (Sweden)

    A.M.S. Ali

    2013-12-01

    Full Text Available A study on avifauna was conducted in and around the campus of the Sálim Ali Centre for Ornithology and Natural History, Anaikatty hills, Coimbatore, Southern India between January 2012 and May 2013. A total of 145 species of birds belonging to 48 families and 15 orders was recorded of which 73 species were residents, 58 local migrants and 14 were winter migrants. Forty species of birds were recorded breeding here. The birds of the campus included two species endemic to Western Ghats and 14 species listed under Schedule-I of the Indian Wildlife (Protection Act, 1972.

  14. Birds of the Sálim Ali Centre for Ornithology and Natural History Campus, Anaikatty Hills, southern India

    OpenAIRE

    A.M.S. Ali; S.B. Shanthakumar; S.R. Kumar; Chandran, R; S.S. Marimuthu; P. R. Arun

    2013-01-01

    A study on avifauna was conducted in and around the campus of the Sálim Ali Centre for Ornithology and Natural History, Anaikatty hills, Coimbatore, Southern India between January 2012 and May 2013. A total of 145 species of birds belonging to 48 families and 15 orders was recorded of which 73 species were residents, 58 local migrants and 14 were winter migrants. Forty species of birds were recorded breeding here. The birds of the campus included two species endemic to Western Ghats and 14 sp...

  15. Epiduralni spinalni apsces nakon vađenja zuba- rijetka, ali moguće fatalna komplikacija

    OpenAIRE

    Škrobot, Renato; Macan, Darko

    2004-01-01

    Poznate su komplikacije odontogenog apscesa, a otežano gutanje kod submandibularnog ili pterigomandibularnog apscesa ozbiljan je i pažnje vrijedan znak. Ali većini liječnika nije poznato da ukočen i bolan vrat može biti pokazatelj komplikacije odontogene infekcije. Upravo je to jedan od prvih, a ujedno i glavni simptom kod epiduralnoga spinalnog apscesa. U literaturi se navodi samo nekoliko slučajeva obrađenih pacijenata s takvim apscesom. Specifičnost epiduralnog spinalnog apscesa jest št...

  16. The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.

    Science.gov (United States)

    Tian, Xiaochen; Devi-Rao, Gayathri; Golovanov, Alexander P; Sandri-Goldin, Rozanne M

    2013-07-01

    Herpes simplex virus 1 (HSV-1) protein ICP27 enables viral mRNA export by accessing the cellular mRNA export receptor TAP/NXF, which guides mRNA through the nuclear pore complex. ICP27 binds viral mRNAs and interacts with TAP/NXF, providing a link to the cellular mRNA export pathway. ICP27 also interacts with the mRNA export adaptor protein Aly/REF, which binds cellular mRNAs and also interacts with TAP/NXF. Studies using small interfering RNA (siRNA) knockdown indicated that Aly/REF is not required for cellular mRNA export, and similar knockdown studies during HSV-1 infection led us to conclude that Aly/REF may be dispensable for viral RNA export. Recently, the structural basis of the interaction of ICP27 with Aly/REF was elucidated at atomic resolution, and it was shown that three ICP27 residues, W105, R107, and L108, interface with the RNA recognition motif (RRM) domain of Aly/REF. Here, to determine the role the interaction of ICP27 and Aly/REF plays during infection, these residues were mutated to alanine, and a recombinant virus, WRL-A, was constructed. Virus production was reduced about 10-fold during WRL-A infection, and export of ICP27 protein and most viral mRNAs was less efficient. We conclude that interaction of ICP27 with Aly/REF contributes to efficient viral mRNA export.

  17. Frequency of Meningitis in Children Presenting with Febrile Seizures at Ali- Asghar Children’s Hospital

    Directory of Open Access Journals (Sweden)

    Azita TAVASOLI

    2014-12-01

    Full Text Available How to Cite This Article: Tavasoli A, Afsharkhas L, Edraki A. Frequency of Meningitis in Children Presenting with Febrile Seizure in Ali-Asghar Children’s Hospital. Iran J Child Neurol. 2014 Autumn; 8(4:51-56.AbstractObjectiveFebrile seizures (FS are the most common type of childhood seizures, affecting 2–5% of children. As the seizure may be the sole presentation of bacterial meningitis in febrile infants, it is mandatory to exclude underlying meningitis in children presenting with fever and seizure. To determine the frequency of meningitis in children with FS and related risk factors, the present study was conducted at Ali-Asghar Children’s Hospital.Materials & MethodsThe records of children aged from 1-month–6 years of age with fever and seizure admitted to the hospital from October 2000–2010 were studied. The charts of patients who had undergone a lumbar puncture were studied and cases of meningitis were selected. The related data was collected and analyzed with SPSS version 16.ResultsA total of 681 patients with FS were known from which 422 (62% lumbar punctures (LP were done. Meningitis (bacterial or aseptic was identified in 19 cases (4.5%, 95% CI 2.9–6.9 by Wilson- Score internal and bacterial meningitis in 7 (1.65%, 95% CI 0.8–3.3. None of the patients with bacterial meningitis had meningeal irritation signs. Complex FS, first attack of FS, and impaired consciousness were more common in patients with meningitis when compared to non- meningitis patients.ConclusionMeningitis is more common in patients less than 18 months presenting with FS; however, complex features of seizures, first attack of FS, or impaired consciousness seem significant risk factors for meningitis in these children and an LP should be considered in this situation. ReferencesKimia A, Ben-Joseph EP, Rudleo T, et al. Yield of lumbar puncture among children who present with their first complex febrile seizure. Pediatrics.2010; 126: 62

  18. The Effects of Physical Education Course on Mental Health of Students in Bu-Ali Sina University, Hamedan-Iran

    Directory of Open Access Journals (Sweden)

    Sajad Moemeni Piri

    2015-03-01

    Full Text Available IntroductionMental disorders are a major cause of morbidity and disability in the worldand can reduce the success and academic achievement. Experts believe that exercise can be used as a means to achieve favorable mental status. The aim of this study was to investigate the effect of physical education course (I on mental health of Bu-Ali Sina University students, Hamadan.MethodologyIn this descriptive study, 108 students of Bu-Ali Sina University, were randomly selected as research sample. Data collection tool was the 28-item standard questionnaire of Mental Health of Goldberg (GHQ-28 with 0. 89 reliability. To determine the suspected cases of mental disorders, cutoff point 23 has been used. Data were analyzed using descriptive and inferential statistics (Pair t-tests at the significance level 0.05.ResultsThe findings showed that the average pretest score of students` mental health was 21.86 ± 8.96 and the average post-test score was 22.55 ± 10.83. 40.7 percent of participants were suspected to have mental disorders before participation in physical education classes (score above 23 and decreased to 37% after the end of the semester, the dependent t-test results showed no significant difference between students` mental health before and after the general physical education (p> 0.05. The post-test results showed that depressive symptoms were significantly increased (p>0.05; 2.81 ± 5.64.Conclusion

  19. ALIS: An efficient method to compute high spectral resolution polarized solar radiances using the Monte Carlo approach

    International Nuclear Information System (INIS)

    An efficient method to compute accurate polarized solar radiance spectra using the (3D) Monte Carlo model MYSTIC has been developed. Such high resolution spectra are measured by various satellite instruments for remote sensing of atmospheric trace gases. ALIS (Absorption Lines Importance Sampling) allows the calculation of spectra by tracing photons at only one wavelength. In order to take into account the spectral dependence of the absorption coefficient a spectral absorption weight is calculated for each photon path. At each scattering event the local estimate method is combined with an importance sampling method to take into account the spectral dependence of the scattering coefficient. Since each wavelength grid point is computed based on the same set of random photon paths, the statistical error is almost same for all wavelengths and hence the simulated spectrum is not noisy. The statistical error mainly results in a small relative deviation which is independent of wavelength and can be neglected for those remote sensing applications, where differential absorption features are of interest. Two example applications are presented: The simulation of shortwave-infrared polarized spectra as measured by GOSAT from which CO2 is retrieved, and the simulation of the differential optical thickness in the visible spectral range which is derived from SCIAMACHY measurements to retrieve NO2. The computational speed of ALIS (for 1D or 3D atmospheres) is of the order of or even faster than that of one-dimensional discrete ordinate methods, in particular when polarization is considered.

  20. Pharmacognostic and phytochemical analyses of leaves and seed storage of abutilon pakistanicum jafri and ali an endemic plant of pakistan

    International Nuclear Information System (INIS)

    There are vast varieties of medicinal plant in the world having therapeutical importance. With increasing popularity of herbal medicine as a curative measure, the need for correct identification and standardization of the plant is also increased. Present work was performed to study the pharmacognostic and phytochemical characters of leaves and exsitu seed conservation by seed storage of Abutilon pakistanicum Jafri and Ali. It is an endemic plant, found in the sub tropical regions of Pakistan and is used in traditional medicine for treating rheumatism. The leaves of Abutilon pakistanicum Jafri andAli were investigated for pharmacognostic parameters. Phytochemical screening, macroscopic characters, physiochemical attributes and fluorescence analysis. The results revealed the presence of pharmacologically active compounds like alkaloids, flavonoids, terpinoids, saponins and phenolic compounds, leaf constant values and the extractive values obtained were found close to the values reported for other Abutilon species, while high ash value indicated presence of impurities in the crude drug. The investigation provides information for correct identification and authentication of plant species for further studies and medicinal evaluation of the species. (author)

  1. Properties of AlyGa1-yN/AlxGa1-xN/AlN/GaN Double-Barrier High Electron Mobility Transistor Structure

    Institute of Scientific and Technical Information of China (English)

    GUO Lun-Chun; WANG Xiao-Liang; XIAO Hong-Ling; RAN Jun-Xue; Wang Cui-Mei; MA Zhi-Yong; LUO Wei-Jun; WANG Zhan-Guo

    2009-01-01

    Electrical properties of AlyGa1-yN/AlxGa1-xN/AIN/GaN structure are investigated by solving coupled Schrodinger and Poisson equation self-consistently. Our calculations show that the two-dimensional electron gas (2DEG) den-sity will decrease with the thickness of the second barrier (AlyGa1-yN) once the AIN content of the second barrier is smaller than a critical value yc, and will increase with the thickness of the second barrier (AlyGa1-yN) when the critical AIN content of the second barrier yc is exceeded. Our calculations also show that the critical AlN content of the second barrier yc will increase with the AlN content and the thickness of the first barrier layer (AlxGa1-xN).

  2. Palyginamųjų daugiklių metodo taikymo nelikvidžiose rinkose galimybių vertinimas. Baltijos šalių atvejis

    OpenAIRE

    Vilkauskaitė, Gintarė

    2013-01-01

    Darbe analizuojamos palyginamųjų daugiklių metodo taikymo galimybės Baltijos šalių listinguojamoms įmonėms. Darbo tikslas - įvertinti palyginamųjų daugiklių metodo taikymo galimybes nelikvidžiose rinkose Baltijos šalių listinguojamų įmonių pavyzdžiu. Darbą sudaro trys dalys, kurių pirmojoje pristatomi daugiklių metodo privalumai, trūkumai, praktinio pritaikymo etapai ir skirtingų metodų, naudojamų kiekviename praktinio pritaikymo etape, poveikio vertinimo rezultatams apžvalga. Antroje dalyje ...

  3. Šiaurės Amerikos laisvosios prekybos sutartis, jos veiklos mechanizmas bei įtaka šalių dalyvių ekonominei ir socialinei raidai

    OpenAIRE

    Maslauskaitė, Indrė

    2007-01-01

    Šiuolaikinis pasaulinis ūkis pasižymi nuolatos vykstančiais integraciniais procesais, visos šalys dalyvauja tarptautin÷je prekyboje, išskyrus tokias retas išimtis kaip Šiaur÷s Kor÷ja. Šalys d÷l įvairiausių priežasčių jungiasi į asociacijas, bendrijas, sąjungas, sudarydamos sutartis, konvencijas, susitarimus. Globalizacijos procesas daro reikšmingos įtakos tarptautin÷ms kapitalo rinkoms, prekių rinkoms, makroekonominei (biudžeto) politikai, pramon÷s santykiams ir darbo rinkos re...

  4. Regions of Different Confinement in Low-Dimensional AlyInxGa1−x−yN Quantum Structures

    Directory of Open Access Journals (Sweden)

    A. Gröning

    2007-01-01

    Full Text Available The optical properties of metal-organic vapor phase epitaxy grown AlyInxGa1−x−yN quantum dot structures have been studied by time-resolved photoluminescence experiments. We investigated the recombination dynamics of the photo-exited carriers in dependence of the growth parameters such as aluminium flow and the duration of the growth interruption after the dot deposition. Our results confirm the presence of localized states, where the degree of localization is strongly dependent on the growth conditions. To describe this behavior, we propose a band structure with coupled potentials for these nanostructures. Finally, we demonstrate state filling to prove the zero-dimensional character of the strongly localized states in our quaternary quantum dots.

  5. Plasticité du droit constitutionnel et dynamique de l’autoritarisme dans la Tunisie de Ben Ali

    Directory of Open Access Journals (Sweden)

    Éric Gobe

    2012-02-01

    Full Text Available Le droit des institutions politiques dans la Tunisie de Ben Ali apparaît particulièrement plastique et instable car ce sont les échéances politiques liées à la pérennisation du régime autoritaire qui dictent le rythme et la nature des changements institutionnels. Ce droit est conçu de façon à rendre impensable l’éventualité d’une alternance au sommet de l’État tout en permettant aux pouvoirs publics tunisiens de tenir un discours sur la résolution de la Tunisie à approfondir son engagement démocratique. Les récents textes constitutionnels et législatifs organisant la vie politique concourent, dans le même temps à limiter formellement les pratiques autoritaires tout en les autorisant si nécessaire.

  6. New insights into the structure of Om Ali-Thelepte basin, central Tunisia, inferred from gravity data: Hydrogeological implications

    Science.gov (United States)

    Harchi, Mongi; Gabtni, Hakim; El Mejri, Hatem; Dassi, Lassaad; Mammou, Abdallah Ben

    2016-08-01

    This work presents new results from gravity data analyses and interpretation within the Om Ali-Thelepte (OAT) basin, central Tunisia. It focuses on the hydrogeological implication, using several qualitative and quantitative techniques such as horizontal gradient, upward continuation and Euler deconvolution on boreholes log data, seismic reflection data and electrical conductivity measurements. The structures highlighted using the filtering techniques suggest that the Miocene aquifer of OAT basin is cut by four major fault systems that trend E-W, NE-SW, NW-SE and NNE-SSW. In addition, a NW-SE gravity model established shows the geometry of the Miocene sandstone reservoir and the Upper Cretaceous limestone rocks. Moreover, the superimposition of the electrical conductivity and the structural maps indicates that the low conductivity values of sampled water from boreholes are located around main faults.

  7. Unsupervised Clustering of EO-1 ALI Panchromatic Data Using Multilevel Local Pattern Histograms and Latent Dirichlet Allocation Classification

    Directory of Open Access Journals (Sweden)

    Costăchioiu Teodor

    2011-09-01

    Full Text Available Over the last years huge amounts of remotely sensed data have been acquired. Among remote sensing satellites we can mention the EO-1 ALI mission, designed as a platform for testing and validation of new technologies that will be incorporated in the forthcoming Landsat LDCM satellite. In this paper we propose a method for unsupervised clustering of the panchromatic band of EO-1 data using multilevel local pattern histograms to capture local and spatial information by recording the size and distribution of bright, dark and homogenous area within a moving window. For classification task we propose the use of Latent Dirichlet Allocation, a method that can discover complex patterns in data, providing results with a high semantic meaning, close to expectations of the human user.

  8. Bensaâd Ali (dir., L’eau et ses enjeux au Sahara, Iremam, Karthala, 2011, 242 p.

    Directory of Open Access Journals (Sweden)

    Jean-Louis Marçot

    2011-11-01

    Full Text Available Je dirai en premier ma déception. Comme le suggère Ali Bensaâd à l’entrée du livre qu’il a dirigé, l’enjeu de l’eau au Sahara n’est ni plus ni moins que la conservation de la vie dans ce milieu qui lui est particulièrement hostile - la vie sous tous ses aspects. Or cet enjeu « vital » a été négligé au profit d’une approche micro-géographique. C’est pourtant par cette entrée que le travail collectif aurait pu légitimement intéresser un vaste public. Comment l’eau existe-t-elle à l’état naturel...

  9. Assessment of a volume-dependent dynamic respiratory system compliance in ALI/ARDS by pooling breathing cycles

    International Nuclear Information System (INIS)

    New methods were developed to calculate the volume-dependent dynamic respiratory system compliance (Crs) in mechanically ventilated patients. Due to noise in respiratory signals and different characteristics of the methods, their results can considerably differ. The aim of the study was to establish a practical procedure to validate the estimation of intratidal dynamic Crs. A total of 28 patients from intensive care units of eight German university hospitals with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) were studied retrospectively. Dynamic volume-dependent Crs was determined during ongoing mechanical ventilation with the SLICE method, dynostatic algorithm and adaptive slice method. Conventional two-point compliance C2P was calculated for comparison. A number of consecutive breathing cycles were pooled to reduce noise in the respiratory signals. Crs-volume curves produced with different methods converged when the number of pooling cycles increased (n ≥ 7). The mean volume-dependent Crs of 20 breaths was highly correlated with mean C2P (C2P,mean = 0.945 × Crs,mean − 0.053, r2 = 0.968, p < 0.0001). The Bland–Altman analysis indicated that C2P,mean was lower than Crs,mean (−2.4 ± 6.4 ml cm−1 H2O, mean bias ± 2 SD), but not significant according to the paired t-test (p > 0.05). Methods for analyzing dynamic respiratory mechanics are sensitive to noise and will converge to a unique solution when the number of pooled cycles increases. Under steady-state conditions, assessment of the volume-dependent Crs in ALI/ARDS patients can be validated by pooling respiratory data of consecutive breaths regardless of which method is applied. Confidence in dynamic Crs determination may be increased with the proposed pooling. (note)

  10. Changes of plasma renin activity and angiotensin Ⅱ level in and its sig-nificance%血浆PRA、AngⅡ在ALI/ARDS患者中的变化和意义

    Institute of Scientific and Technical Information of China (English)

    夏炎火; 郑小蕾; 王丹; 余方友; 林锡芳; 潘景业

    2014-01-01

    目的:探讨PRA、AngⅡ在ALI/ARDS患者中的变化和意义。方法测定ALI/ARDS和非ALI/ARDS患者血浆PRA和AngⅡ浓度,进行APACHEⅡ评分和LIS评分,计算病死率,进一步将患者按预后分组,进行比较和相关分析,利用ROC曲线评价PRA和AngⅡ的诊断分辨度。结果与非ALI/ARDS组相比,ALI/ARDS组血浆PRA和AngⅡ浓度明显增高(P<0.05),死亡组血浆PRA和AngⅡ浓度高于存活组(P <0.05)。 PRA、AngⅡ与APACHEⅡ评分、LIS、乳酸(LAC)间均呈明显正相关。 PRA在预测ALI/ARDS方面有显著意义(AUC=0.705,P=0.001),AngⅡ对预测ALI/ARDS也有显著意义(AUC=0.672, P=0.007)。在预测ALI/ARDS方面,PRA、AngⅡ与LIS相比无明显差异(P=0.923,P=0.713)。结论 ALI/ARDS患者血浆PRA和AngⅡ水平明显升高,两者在预测ALI/ARDS和判断其预后方面均有重要意义,而AngⅡ在预测ALI/ARDS中的特异度较高。%Objective To investigate the clinical significance and levels of plasma renin activity (PRA), Angiotensin (Ang) Ⅱ in ALI / ARDS patients. Methods The levels of PRA and AngⅡ, APACHE Ⅱ score, lung injury score(LIS), and mortality were analyzed in ALI/ARDS patients and non-ALI/ARDS group. After the patients were grouped accord-ing to prognosis, correlation analysis and ROC curve to evaluate diagnostic efficacy of PRA and AngⅡ were performed. Results Compared with non- ALI/ARDS group, the levels of PRA and AngⅡ were significantly increased in ALI/ARDS (P<0.05). In the death group, the levels of PRA and AngⅡwere higher than that of the survival group (P<0.05). It was significant positive correlation between APACHEⅡ score,LIS,lactic acid (LAC) and PRA, so as AngⅡ. In pre-dicting ALI/ARDS, PRA was significant (AUC=0.705, P=0.001), so as AngⅡ(AUC=0.672, P =0.007). In predict-ing ALI/ARDS, there was no significant difference between PRA and LIS (P=0.923), and also between AngⅡ and LIS (P = 0.713). Conclusion

  11. ALI BEY HÜSEYNZADE’S ROLE IN WORK OF COMMON TURKIC LANGUAGE IN XX CENTURY XX. YÜZYILDA ORTAK TÜRK DİLİ ÇALIŞMALARINDA ALI BEY HÜSEYNZADE`NIN ROLÜ

    Directory of Open Access Journals (Sweden)

    Elza SEMEDLİ

    2009-12-01

    Full Text Available In this research, we will speak about the thoughts of the tireless defender of the Turkic Union Ali bay Huzeynzadeh on the Turkic Language. As it is known, the XX century was a period of rapid changes of sociopolitical tension, disorders, events both in Azerbaijan and geographical regions where Turks live. These disorders and rapid changes of affected the formation of literary language. Enlighteners, media members of that period played a special role in this process. The agenda was in which language and dialect Turk nations should write. The opinions were different. Some intellectuals were supporters of the Ottoman dialect, others suggested the local dialects. Ali bay Huseynzadeh told that all dialects are perfect and defended common opinion. Bu çalışmada İsmail Kaspıralı ile başlayan “Dilde, fikirde, işte birlik” düşüncesinin ısrarlı takipçisi Ali Bey Hüseynzade`nin XX.yüzyılın başlangıcından itibaren Türk ittihadı uğruna yaptığı yoğun mücadelenin sadece bir kısmını, Ortak Türk dili için Azerbaycan`da verdiği mücadeleyi incelemeye, bu dahi mütefekkirin kendi eserlerinden yola çıkarak incelemeye çalışacağız. Bilindiği gibi, XX.yüzyılın başlangıcında Azerbaycan`da, aynı zamanda Türk kavimlerinin yaşadığı diğer coğrafyalarda, birçok alanda görülen mücadele, toplumsal-siyasi gerginlik, karmaşa, olayların hızlı değişimi edebi dilin şekillenmesini de önemli ölçüde etkiliyordu. Özellikle, dönemin ileri gelen eğitimcileri, basın mensubları bu konuyu sürekli gündemde tutarak “hangi dil veya şiveyle yazmalı” sorusuyla tartışmayı alevlendiriyodu. Işte bu soru bütün Türk kavimlernin gündemine oturuyor ve bu konudaki görüşler zamanla şekillenerek iki istikamette yoğunlaşıyordu. Bir kısım aydınlar Osmanlı Türkçesinin olduğu gibi almak gerektiğini söylerken, bir kısmı bir dialektin hazır alınmasının doğru olmadığını, her şivenin kendi

  12. Examination of the "Theory of Guidance" in the View of 'Ali Ibn Abi Talib (A): An Exploration into the Nahj Al-Balaghah

    Science.gov (United States)

    Rostami-Nasab, Abas Ali; Tajedini, Oranus; Sadatmoosavi, Ali

    2016-01-01

    This study examines the "Theory of Guidance" according to 'Ali ibn Abi Talib (a). This theory is based on three divine covenants or fundamentals in guidance including the divine Prophet, the divine Book, and the divine human nature ("fitrat"). Research in this regard seems essential because this theory has not been previously…

  13. Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication.

    Science.gov (United States)

    Li, Da-Jiang; Verma, Dinesh; Swaminathan, Sankar

    2012-09-01

    Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is expressed early during lytic KSHV replication, enhances expression of many KSHV genes, and is essential for virus production. ORF57 is a member of a family of proteins conserved among all human and many animal herpesviruses that are multifunctional regulators of gene expression and act posttranscriptionally to increase accumulation of their target mRNAs. The mechanism of ORF57 action is complex and may involve effects on mRNA transcription, stability, and export. ORF57 directly binds to REF/Aly, a cellular RNA-binding protein component of the TREX complex that mediates RNA transcription and export. We analyzed the effects of an ORF57 mutation known to abrogate REF/Aly binding and demonstrate that the REF-binding mutant is impaired in activation of viral mRNAs and noncoding RNAs confined to the nucleus. Although the inability to bind REF leads to decreased ORF57 activity in enhancing gene expression, there is no demonstrable effect on nuclear export of viral mRNA or the ability of ORF57 to support KSHV replication and virus production. These data indicate that REF/Aly-ORF57 interaction is not essential for KSHV lytic replication but may contribute to target RNA stability independent of effects on RNA export, suggesting a novel role for REF/Aly in viral RNA metabolism.

  14. Muusikamaailm : Ozawa festival Matsumotos. Pidustused Utrechtis ülehomseni. Philip Glassi uusteos Salzburgis. Alexandre Lagoya surnud. Frangiz Ali-Zade asutamine Luzernis. Wolfgang Wagner 80 / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    1999-01-01

    H.Saito mälestusfestivalist "Saito Kinen" 29.08-12.09 Jaapanis. Utrechti varajase muusika pidustustest 27.08-5.09. P.Glassi teose "Requiem, Bardo and Nimanakaya" maailmaesiettekandest Salzburgi suvefestivalil 28.08. A. Lagoya elust ja tegevusest. Luzerni festivali resideerivaks heliloojaks oli F.Ali-Zade. W. Wagneri tegevusest impressaariona

  15. Experiences in application of professional database about ALI/ARDS following open heart surgery%心内直视手术后ALI/ARDS专业数据库的应用体会

    Institute of Scientific and Technical Information of China (English)

    陈柏成; 陈建新; 肖颖彬; 陈林; 钟前进; 王学锋

    2005-01-01

    目的将数据库技术应用于心血管外科临床资料的管理以及我科承担的全军医药卫生基金课题的实施与开展.方法应用Microsoft Access XP软件、VB6.0、Microsoft SQL建立心内直视手术后ALI/ARDS专业数据库,通过建立专业字典与临床资料表格实现了数据库的专业性;通过控件属性的设置建立了实用的数据录入窗体,减少文字输入,减轻工作量;通过SQL命令语句实现数据库的查询功能;通过与统计软件的联结实现高效能的统计分析功能.结果采用该实用的专业数据库,顺利完成了体外循环心内直视手术后血气分析的变化特点与临床意义、体外循环后ALI/ARDS病例临床分析、体外循环后长时间呼吸机支持与ARDS发生的危险因素分析等多项研究,取得了良好的效果.结论我们自行构建的心脏外科专业数据库,可较全面地收集心内直视手术病人临床资料,从而提高了临床研究的效率,也增强了临床研究的科学性.专业数据库作用的发挥有赖于临床医疗工作中的规范化与制度化.

  16. Probing the structures of gold-aluminum alloy clusters AuxAly-: a joint experimental and theoretical study

    Science.gov (United States)

    Khetrapal, Navneet Singh; Jian, Tian; Pal, Rhitankar; Lopez, Gary V.; Pande, Seema; Wang, Lai-Sheng; Zeng, Xiao Cheng

    2016-05-01

    Besides the size and structure, compositions can also dramatically affect the properties of alloy nanoclusters. Due to the added degrees of freedom, determination of the global minimum structures for multi-component nanoclusters poses even greater challenges, both experimentally and theoretically. Here we report a systematic and joint experimental/theoretical study of a series of gold-aluminum alloy clusters, AuxAly- (x + y = 7,8), with various compositions (x = 1-3 y = 4-7). Well-resolved photoelectron spectra have been obtained for these clusters at different photon energies. Basin-hopping global searches, coupled with density functional theory calculations, are used to identify low-lying structures of the bimetallic clusters. By comparing computed electronic densities of states of the low-lying isomers with the experimental photoelectron spectra, the global minima are determined. It is found that for y >= 6 there is a strong tendency to form the magic-number square bi-pyramid motif of Al6- in the AuxAly- clusters, suggesting that the Al-Al interaction dominates the Au-Au interaction in the mixed clusters. A closely related trend is that for x > 1, the gold atoms tend to be separated by Al atoms unless only the magic-number Al6- square bi-pyramid motif is present, suggesting that in the small-sized mixed clusters, Al and Au components do not completely mix with one another. Overall, the Al component appears to play a more dominant role due to the high robustness of the magic-number Al6- square bi-pyramid motif, whereas the Au component tends to be either ``adsorbed'' onto the Al6- square bi-pyramid motif if y >= 6, or stays away from one another if x searches, coupled with density functional theory calculations, are used to identify low-lying structures of the bimetallic clusters. By comparing computed electronic densities of states of the low-lying isomers with the experimental photoelectron spectra, the global minima are determined. It is found that for y >= 6

  17. A little known astronomer in the late Islamic period. A study of Qasim ali al-Qayini's manuscripts

    CERN Document Server

    Akbari, Marjan

    2012-01-01

    It is widely believed that the advance of science in the Islamic world after the mid-fifteenth century A.D. suffered a decline. For the purpose of examining this belief, a manuscript by Qasim ali al-Qayini (ca. A.D.1685) was chosen based on previous works which considered it a valuable source on the history of optics that had not been studied before. After studying his major optical manuscript, titled Manazir wa Maraya, it was found very interesting that the majority of al-Qayini's propositions relating to natural phenomena were not merely geometrical definitions, but that the proofs related to astronomy. As an example, in one case, which had not been explained in previous astronomical and optical manuscripts, al-Qayini tried, despite lacking a vigorous proof, to show how a special point in a room could be lit up by sunlight throughout the year. His particular interest in astronomy led us to a general study of his other works, and it is worth noting that out of the nineteen works that have been attributed to ...

  18. Investigating Factors Affecting Knowledge of Agricultural Science Students of Bu-Ali Sina University of Iran toward Organic Farming

    Directory of Open Access Journals (Sweden)

    Farid Golzardi

    2012-04-01

    Full Text Available The purpose of this research was to investigate viewpoints of students about organic farming. The undesirable negative consequence of conventional farming has lead to the need and emphasis for new sustainable agricultural production techniques. Agricultural students play an important role in extension and spread of the system. This research was carried out applying a survey method. The respondents were 150 agricultural students from Bu-ali Sina University of Hamedan. Instrument of data gathering was questionnaire. Likert-type scales were used to measure knowledge and attitude toward organic farming. Cronbach’s alpha coefficient was higher than 0.7 which was favorable. Validity of the questionnaire was confirmed by an experts’ panel. Data analysis was accomplished using SPSS. The results indicated that access to environmental information as well as the attitude toward environmental issues has positive and direct effect on knowledge toward organic farming. Based on the results, variables of attitude towards health within the framework of environmental attitude exert indirect effects of knowledge toward organic farming.

  19. Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.

    Science.gov (United States)

    Hung, Ming-Lung; Hautbergue, Guillaume M; Snijders, Ambrosius P L; Dickman, Mark J; Wilson, Stuart A

    2010-06-01

    The REF/ALY mRNA export adaptor binds TAP/NXF1 via an arginine-rich region, which overlaps with its RNA-binding domain. When TAP binds a REF:RNA complex, it triggers transfer of the RNA from REF to TAP. Here, we have examined the effects of arginine methylation on the activities of the REF protein in mRNA export. We have mapped the arginine methylation sites of REF using mass spectrometry and find that several arginines within the TAP and RNA binding domains are methylated in vivo. However, arginine methylation has no effect on the REF:TAP interaction. Instead, arginine methylation reduces the RNA-binding activity of REF in vitro and in vivo. The reduced RNA-binding activity of REF in its methylated state is essential for efficient displacement of RNA from REF by TAP in vivo. Therefore, arginine methylation fine-tunes the RNA-binding activity of REF such that the RNA-protein interaction can be readily disrupted by export factors further down the pathway.

  20. Les « faux » mariages homosexuels de Sidi Ali au Maroc : enjeux d’un scandale médiatique

    Directory of Open Access Journals (Sweden)

    Florence Bergeaud-Blackler

    2012-01-01

    Full Text Available Les affaires de « mariages homosexuels » à Ksar el Kebir puis à Sidi Ali ont fait grand bruit dans la presse marocaine. Au-delà de l’émotion soulevée par le scandaleux amalgame entre l’institution respectée du mariage et une forme illégale de sexualité, elle a mis en évidence une transformation du traitement public de la question homosexuelle. Le changement de ton de la presse reflète-t-il celui de l’attitude de la société marocaine vis-à-vis de l’homosexualité ? Assiste-t-on à l’émergence d’une communauté homosexuelle militant pour la défense de ses droits ? Les « mariages » de Ksar el Kebir et de Sidi Ali constituent-ils des démonstrations visant à briser le tabou de l’homosexualité par l’émergence d’une « fierté » homosexuelle ? D’enquêtes menées à Sidi Ali, Fez et Casablanca, nous concluons que la médiatisation autour des affaires de mariages d’homosexuels a été un instrument d’une stratégie d’un « retour de la morale » aux relents nationalistes consécutive à la période d’establishement du roi Mohamed VI. L’article s’attache à montrer les enjeux locaux et nationaux d’une fausse chasse aux sorcières dans un pays où les conditions d’un débat sur la dépénalisation de l’homosexualité ne semblent pas encore réalisées.

  1. Stress conditions promote yeast Gap1 permease ubiquitylation and down-regulation via the arrestin-like Bul and Aly proteins.

    Science.gov (United States)

    Crapeau, Myriam; Merhi, Ahmad; André, Bruno

    2014-08-01

    Gap1, the yeast general amino acid permease, is a convenient model for studying how the intracellular traffic of membrane transporters is regulated. Present at the plasma membrane under poor nitrogen supply conditions, it undergoes ubiquitylation, endocytosis, and degradation upon activation of the TORC1 kinase complex in response to an increase in internal amino acids. This down-regulation is stimulated by TORC1-dependent phosphoinhibition of the Npr1 kinase, resulting in activation by dephosphorylation of the arrestin-like Bul1 and Bul2 adaptors recruiting the Rsp5 ubiquitin ligase to Gap1. We report here that Gap1 is also down-regulated when cells are treated with the TORC1 inhibitor rapamycin or subjected to various stresses and that a lack of the Tco89 subunit of TORC1 causes constitutive Gap1 down-regulation. Both the Bul1 and Bul2 and the Aly1 and Aly2 arrestin-like adaptors of Rsp5 promote this down-regulation without undergoing dephosphorylation. Furthermore, they act via the C-terminal regions of Gap1 not involved in ubiquitylation in response to internal amino acids, whereas a Gap1 mutant altered in the N-terminal tail and resistant to ubiquitylation by internal amino acids is efficiently down-regulated under stress via the Bul and Aly adaptors. Although the Bul proteins mediate Gap1 ubiquitylation of two possible lysines, Lys-9 and Lys-16, the Aly proteins promote ubiquitylation of the Lys-16 residue only. This stress-induced pathway of Gap1 down-regulation targets other permeases as well, and it likely allows cells facing adverse conditions to retrieve amino acids from permease degradation.

  2. Study of np2P1/2,3/2 Rydberg series of AlI by the method of laser stepwise excitation and ionization by electric field

    International Nuclear Information System (INIS)

    Frequencies of the 4s2S1/2-np2P1/2,3/2 transitions are measured and the energies of high-lying P states, as well as the ionization energy of aluminum atoms, are determined by the method of two-step laser excitation and ionization of excited atoms of AlI by an electric field. 4 refs., 3 figs., 1 tab

  3. Mesostructured HfxAlyO2 Thin Films as Reliable and Robust Gate Dielectrics with Tunable Dielectric Constants for High-Performance Graphene-Based Transistors.

    Science.gov (United States)

    Lee, Yunseong; Jeon, Woojin; Cho, Yeonchoo; Lee, Min-Hyun; Jeong, Seong-Jun; Park, Jongsun; Park, Seongjun

    2016-07-26

    We introduce a reliable and robust gate dielectric material with tunable dielectric constants based on a mesostructured HfxAlyO2 film. The ultrathin mesostructured HfxAlyO2 film is deposited on graphene via a physisorbed-precursor-assisted atomic layer deposition process and consists of an intermediate state with small crystallized parts in an amorphous matrix. Crystal phase engineering using Al dopant is employed to achieve HfO2 phase transitions, which produce the crystallized part of the mesostructured HfxAlyO2 film. The effects of various Al doping concentrations are examined, and an enhanced dielectric constant of ∼25 is obtained. Further, the leakage current is suppressed (∼10(-8) A/cm(2)) and the dielectric breakdown properties are enhanced (breakdown field: ∼7 MV/cm) by the partially remaining amorphous matrix. We believe that this contribution is theoretically and practically relevant because excellent gate dielectric performance is obtained. In addition, an array of top-gated metal-insulator-graphene field-effect transistors is fabricated on a 6 in. wafer, yielding a capacitance equivalent oxide thickness of less than 1 nm (0.78 nm). This low capacitance equivalent oxide thickness has important implications for the incorporation of graphene into high-performance silicon-based nanoelectronics. PMID:27355098

  4. Mass propagation of in vitro plantlets and extraction of bioactive compounds from Eurycoma Longifolia Jack (Tongkat Ali) using cell and organ cultures

    International Nuclear Information System (INIS)

    Eurycoma longifolia Jack or better known in Malaysia as Tongkat Ali is an important herbal plant that owes its popularity locally and worldwide to its aphrodisiac claim and has been sought after as an essential component for the treatment of anti-malarial, anti-ulcer, anti-tumour promoting and anti-parasitic agent and also as health supplements. Quassinoids and canthin-6-one alkaloids contained in Tongkat Ali roots are the main substances having active functions for human body. Propagation is commonly done through seeds or some vegetative means such as cuttings of stems and root, grafting or layering. However, propagation by conventional method is inadequate to meet the demand due to low viability, low germination rate, delayed rooting and long life cycle. Tissue culture has been successfully applied for mass production of plantlets and extraction of many useful secondary metabolites, including pharmaceuticals, pigments and other fine chemicals. Tongkat Ali active substances have also been derived through cell culture technology but its processes need to be optimized before the product can be commercialized. Cell and organ cultures have been proven to be an efficient alternative method for biomass production due to its fast growth and stable metabolite production. In view of its potential commercial value as a plantation crop as well as to conserve its germplasm, micropropagation technique using cell culture system is an attractive method for regeneration and mass propagation. (Author)

  5. Designing Learning Materials within the Framework of the ALIS-T Project: Story Telling Activities for Hearing Impaired Individuals

    Directory of Open Access Journals (Sweden)

    Yasemin Karal

    2014-04-01

    Full Text Available The present study aims to examine the usefulness of 47 stories which were developed as learning materials within the scope of the ALIS-T (Alternative Communication System – Design Project. This project aims to develop a graphical symbolic system which is relevant to Turkish social and cultural systems of understanding. In the study, stories were developed (generated by a Turkish Language and Literature academic taking the objectives of primary 1st year life science, Turkish, and mathematics curricula into account. Stories, which consist of a setting, characters, and plot were developed. The stories were presented to 5 teachers who teach to hearing impaired students in order to check the appropriateness of each. Those teachers’ views were taken into account about the positive/negative effects of stories in the learning and teaching activities. On the other hand, all stories were elaborated by teachers in terms of whether they met the objectives of curriculum and were useful in developing the literacy skills of hearing impaired pupils. Teachers were asked to do any alterations or corrections needed to make stories compatible with curriculum objectives. Obtained data were analyzed descriptively. All participants stated that each of the stories were beneficial and usable for teaching and learning activities. They emphasized that sentences should be short, clear, and comprehendible and found that stories which were too long should be corrected. On the basis of teachers’ feed-back, 39 stories were re-designed and corrected. 8 stories which were found to be unsuitable were excluded from the study

  6. Evaluation of Myocardial Performance Index(Mpi in Beta Thalassemia Major Patients at the Ali Asghar Hospital , Zahedan , Iran

    Directory of Open Access Journals (Sweden)

    R Sohrevardi

    2004-04-01

    Full Text Available Introduction : Patients with major thalassemia need recurrent transfusions and if not treated are at risk of heart dysfunction. Heart tissue could be abnormal in patients who use desferral continously due to iron deposits , fibrosis , hypertrophy and side effects of chronic anemia. Cardiac involvement is the main cause of morbidity and mortality in major thalassemics, so we decided to improve early diagnosis of cardiac involvement by measuring myocardial performance index( MPI . Method & Materials : This case-control study was performed from April 2003 to December 2003 at the Ali-Asghar pediatrics hospital, Zahedan, Iran. MPI of both ventricles was measured by Doppler echocardiography in 48 patients with major thalassemia aged between 10-18 years and compared with 48 age , sex-matched controls. Patients had no abnormality in physical examination , chest x-ray and ECG and echocardiography did not show heart failure. Hemoglobin and serum ferritin levels was measured in all patients before echocardiography. Results: Mean age of patients was 12.3±2.4 years and that in the control group was 12.7±2years . Right ventricle isovolumetric relaxation time (RVIRT (107 ± 14 vs 94 ±14 , p0.05 and LVICT (31 ± 13 vs 21 ± 15 , p0.05 in the two groups. Finally, RVMPI (0.59 ± 0.12 Vs 0.46 ± 0.12 , p<0.001 was increased in 87% of patients and LVMPI (0.49 ± 0.12 Vs 0.41± 0.09 , p0.05. Conclusion: This study showed that RVMPI and LVMPI increase in major thalassemia patients that indicates systolic and diastolic dysfunction and RVMPI increases more than LVMPI. On the other hand, MPI has a direct correlation with serum ferritin . On the basis of this study ,we suggest MPI measurement in serial echocardiography in asymptomatic major thalassemia patients.

  7. Summer students and professor from the United Arab Emirates - from left to right : Alya Ali Binghurair, Shaikha Al Kalbani, Professor Chafia Hejase de Trad, Mariam Al Hassani, Aminah Al Abdouli.

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Summer students and professor from the United Arab Emirates - from left to right : Alya Ali Binghurair, Shaikha Al Kalbani, Professor Chafia Hejase de Trad, Mariam Al Hassani, Aminah Al Abdouli.

  8. Correlation between the interleukin 10-1082 G/A polymorphism and ALI/ARDS: a meta-analysis%白细胞介素10-1082G/A基因多态性与ALI/ARDS关系的Meta分析

    Institute of Scientific and Technical Information of China (English)

    熊浩岚; 陈仲清

    2014-01-01

    目的 研究白细胞介素10-1082G/A基因多态性与急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)的相关性.方法 全面检索PubMed、Embase、Ovid数据库获取白细胞介素10-1082 G/A基因多态性与急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)关系的病例-对照研究,采用等位基因模型、显性遗传模型、隐性遗传模型、共显性遗传模型、超显性遗传模型分别评价ALI/ARDS发病的相对危险度,并按照病种及人种分组对基因多态性进行亚组分析.运用荟萃分析方法综合评价白细胞介素10-1082G/A基因多态性与急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)的相关性.结果 采用等位基因模型、显性基因模型、隐性基因模型、共显性模型及超显性模型分别进行分析,结果均表明IL-10-1082 G/A基因多态性与ALI/ARDS的发病风险无显著相关.结论 10-1082 G/A基因多态性与急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)无明显关系.%Objective To evaluate the correlation between the interleukin 10-1082 G/A polymorphism and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).Methods The case-control studies on correlation between the interleukin 10-1082 G/A polymorphism and ALI/ARDS were collected by searching the databases of PubMed,EMBASE and Ovid.The pooled odds ratios were performed respectively for allele comparison,additive genetic model,dominant genetic model and recessive genetic model and subgroup analysis were also performed by ethnicity.Results Using allele model,dominant model,recessive model,co-dominant model,and overdominant model for analysis,they all produced nonsignificant results.Conclusion There is no significant association between the interleukin 10-1082 G/A polymorphism and ALI/ARDS.

  9. Preparation and Luminescence Properties of MZrO3:Eu3+, A (M=Ca2+, Ba2+; A=Li+, Na+, K+) Phosphors with Perovskite Structure

    Institute of Scientific and Technical Information of China (English)

    MAR B; CEMBRERO-COCA P; SINGH K C; KAUSHIK R D; OM Hari

    2013-01-01

    Calcium and barium zirconate powders based upon CaZrO3:Eu3+, A and BaZrO3:Eu3+, A (A=Li+, Na+, K+) were prepared by combustion synthesis method and heating to ~1000 °C to improve crystal inity. The structure and morphology of materials were examined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). XRD results showed that CaZrO3:Eu3 +, A and BaZrO3:Eu3 +, A (A=Li +, Na +, K +) perovskites possessed orthorhombic and cubic structures, respectively. The morphologies of al powders were very similar consisting of smal , coagulated, cubical particles with narrow size distributions and smooth and regular surfaces. The characteristic luminescences of Eu3+ ions in CaZrO3:Eu3+, A (A=Li+, Na+, K+) lattices were present with strong emissions at 614 and 625 nm for 5D0→7F2 transitions with other weaker emissions observed at 575, 592, 655, and 701 nm corresponding to 5D0→7Fn transitions (where n=0, 1, 3, 4, respectively). In BaZrO3:Eu3 + both the 5D0→7F1 and 5D0→7F2 transitions at 595 and 613 nm were strong. Photoluminescence intensities of CaZrO3:Eu3+ samples were higher than those of BaZrO3:Eu3+ lattices. This remarkable increase of photoluminescence intensity (corresponding to 5D0→7Fn transitions) was observed in CaZrO3:Eu3 + and BaZrO3:Eu3 + if co-doped with Li + ions. An additional broad band composed of many peaks between 440 to 575 nm was observed in BaZrO3:Eu3 +, A samples. The intensity of this band was greatest in Li+ co-doped samples and lowest for K+ doped samples.

  10. Valorisation de boues de STEP dans l'agriculture de Guadeloupe. Synthèse de travaux réalisés à l'INRA

    OpenAIRE

    Sierra, Jorge

    2009-01-01

    Ce diaporama présente d’une part, les travaux réalisés à l’INRA en Guadeloupe concernant l'utilisation des boues en application directe, d’autre part les aspects règlementaires de leur recyclage en agriculture. Ces travaux abordent la qualité des boues, la réponse des cultures, la biodégradation dans le sol et leur valeur comme engrais organique et comme amendement. La deuxième partie traite des aspects règlementaires qui représentent des contraintes à l'utilisation directe des boues aux Anti...

  11. The results of treating Hyaline membrane disease with Surfactant during 1 year at Ali-Asghar Hospital, neonatal intensive care unit

    OpenAIRE

    Naeri F; Samaei H

    1999-01-01

    The routine intake of surfactant as a part of HMD (Hyaline Membrane Disease) treatment had significant effect on the prognosis of premature neonates. But since in our country this drug is not widely and routinely used, and there are not records about its use, we decided to make good on this shortcoming through a retrospective study. During 1 year, 54 neonates with HMD were admitted in Ali-Asghar's NICU, 30 of them had gestational age of less than 34 weeks and for 15 cases, surfactant was...

  12. Investigation on the geomorphological characteristics of the Kabutar Ali Chai watershed (NW Iran) and their role in flood production

    Science.gov (United States)

    Jananeh, Keristineh

    2016-04-01

    The Kabutar Ali Chai watershed is located in NW Iran, 75 km northwest of Tabriz, on the southern hillsides of Mishow mountains. It occupies an area of 67.46 km2 and the length of the main stream is about 24.5 km. Due to the fact that flooding in this watershed threats the downstream rural areas, an investigation was carried out to extract its geomorphologic characteristics and evaluate their contribution in flood production. In this regard, the watershed area was divided into 4 sections based on physiographic and topographic characteristics and stream network: A1 (the southern, low-height part), A2 (mid-western half), A3 (mid-eastern half) and A4 (the northern and highest part). Hypsometric maps and diagrams prepared for the area show that it is confined between 1390 and 3230m elevation levels with a general dip towards the south. The main part of it (57.93%) is located between the elevation levels of 1390 and 1500m. Using the precipitation records of 4 neighboring stations for 20 years, the estimated time of concentration for the runoff varies in the sub-zones: 1.64 hr in A1 (13.9 km stream length and 710 m altitude difference), 0.63 hr in A2 (7.2 km and 1200 m), 0.35 hr in A3 (4.7 km and 1530 m) and 0.48 hr in A4 (5.9 km and 1330 m.) Dip angle is one of the most important factors affecting the time of concentration for runoff and flood production. The average dip of the main part of the area (79.82%) ranges between 0 and 5°, while only the 0.44% of the area has dips about 30-40°. Highest dips are found in the A4 zone (0-40°) and the weight average dip of the total area is 12.94%. Geologically, the most widespread rocks are Pre-Cambrian shales, schists and limestones (Kahar Formation, 43.53%), upper-Cretaceous flysch sequence comprised of shale, limestone and sandstone (13.99%), Miocene marls, silts, clays and limestones (4.13%) and Quaternary alluvial terraces and plains (30.33%). Geomorphologically, this watershed is comprised of 3 types of lands: (1

  13. Technical feasibility of a seabed gallery seawater intake at Ras Abu Ali Island, Arabian Gulf, Saudi Arabia

    KAUST Repository

    Rachman, Rinaldi

    2014-07-23

    Open-ocean intake systems require extensive and advanced pretreatment unit operation to produce feed water with low membrane fouling potential in seawater reverse osmosis (SWRO) facilities. Alternatively, subsurface intake systems tend to produce high quality raw seawater even before pretreatment. Subsurface intakes extract seawater indirectly through the geological structure of shoreline or nearshore sediments. Water percolation through geological units provides physical and biological treatment, so that the raw seawater is microbiologically stable with relatively low particulate and organics content. Overall, utilization of subsurface intakes will reduce the intensity of pretreatment, which reduces operating cost, lowers chemical and energy consumption, and reduces environmental impacts. An important aspect in the feasibility of a subsurface intake is the compatibility of the local geological environment. In this study, a field investigation was conducted at Ras Abu Ali Island in the Arabian Gulf. This location currently contains an of existing oil company facilities and a proposed governmental marine fish hatchery facility. Recreational, commercial, and domestic potable water uses require the need to use the SWRO process to meet demands. Characterization of the shoreline and marine offshore bottom were performed as well as observation of tidal fluctuations and wave heights. A specific grid area was chosen where 35 sediment samples were collected from the seabed floor for laboratory analysis of grain size distribution, sediment porosity, and hydraulic conductivity. Onsite observation showed that the marine bottom has a low slope creating a wide intertidal area. The lowest tidal zone is more than 150 m from the shoreline defining a far seaward boundary for the intake construction point. A relatively thin layer of mixed-type sediment (carbonate and siliciclastic) covers the marine hardground bottom. The unlithified bottom sediment contains a low mud percentage

  14. Using a source-to-source transformation to introduce multi-threading into the AliRoot framework for a parallel event reconstruction

    CERN Document Server

    Lohn, Stefan B; Carminati, Federico

    2012-01-01

    Chip-Multiprocessors are going to support massive parallelism by many additional physical and logical cores. Improving performance can no longer be obtained by increasing clock-frequency because the technical limits are almost reached. Instead, parallel execution must be used to gain performance. Resources like main memory, the cache hierarchy, bandwidth of the memory bus or links between cores and sockets are not going to be improved as fast. Hence, parallelism can only result into performance gains if the memory usage is optimized and the communication between threads is minimized. Besides concurrent programming has become a domain for experts. Implementing multi-threading is error prone and labor-intensive. A full reimplementation of the whole AliRoot source-code is unaffordable. This paper describes the effort to evaluate the adaption of AliRoot to the needs of multi-threading and to provide the capability of parallel processing by using a semi-automatic source-to-source transformation to address the prob...

  15. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.

    Science.gov (United States)

    Zhang, Ting; Liu, Yong; Yang, Xianshu; Martin, Gary E; Yao, Huifang; Shang, Jackie; Bugianesi, Randal M; Ellsworth, Kenneth P; Sonatore, Lisa M; Nizner, Peter; Sherer, Edward C; Hill, Susan E; Knemeyer, Ian W; Geissler, Wayne M; Dandliker, Peter J; Helmy, Roy; Wood, Harold B

    2016-03-10

    A potent and selective Factor IXa (FIXa) inhibitor was subjected to a series of liver microsomal incubations, which generated a number of metabolites. Using automated ligand identification system-affinity selection (ALIS-AS) methodology, metabolites in the incubation mixture were prioritized by their binding affinities to the FIXa protein. Microgram quantities of the metabolites of interest were then isolated through microisolation analytical capabilities, and structurally characterized using MicroCryoProbe heteronuclear 2D NMR techniques. The isolated metabolites recovered from the NMR experiments were then submitted directly to an in vitro FIXa enzymatic assay. The order of the metabolites' binding affinity to the Factor IXa protein from the ALIS assay was completely consistent with the enzymatic assay results. This work showcases an innovative and efficient approach to uncover structure-activity relationships (SARs) and guide drug design via microisolation-structural characterization and ALIS capabilities. PMID:26871940

  16. The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable.

    Science.gov (United States)

    Johnson, Lisa A; Li, Ling; Sandri-Goldin, Rozanne M

    2009-07-01

    Herpes simplex virus 1 (HSV-1) protein ICP27 has been shown to shuttle between the nucleus and cytoplasm and to bind viral RNA during infection. ICP27 was found to interact with the cellular RNA export adaptor protein Aly/REF, which is part of the TREX complex, and to relocalize Aly/REF to viral replication sites. ICP27 is exported to the cytoplasm through the export receptor TAP/NXF1, and ICP27 must be able to interact with TAP/NXF1 for efficient export of HSV-1 early and late transcripts. We examined the dynamics of ICP27 movement and its localization with respect to Aly/REF and TAP/NXF1 in living cells during viral infection. Recombinant viruses with a yellow fluorescent protein (YFP) tag on the N or C terminus of ICP27 were constructed. While the N-terminally tagged ICP27 virus behaved like wild-type HSV-1, the C-terminally tagged virus was defective in viral replication and gene expression, and ICP27 was confined to the nucleus, suggesting that the C-terminal YFP tag interfered with ICP27's C-terminal interactions, including the interaction with TAP/NXF1. To assess the role of Aly/REF and TAP/NXF1 in viral RNA export, these factors were knocked down using small interfering RNA. Knockdown of Aly/REF had little effect on the export of ICP27 or poly(A)(+) RNA during infection. In contrast, a decrease in TAP/NXF1 levels severely impaired export of ICP27 and poly(A)(+) RNA. We conclude that TAP/NXF1 is essential for ICP27-mediated export of RNA during HSV-1 infection, whereas Aly/REF may be dispensable.

  17. Geochemistry of rare earth elements in the Baba Ali magnetite skarn deposit, western Iran – a key to determine conditions of mineralisation

    Directory of Open Access Journals (Sweden)

    Zamanian Hassan

    2016-03-01

    Full Text Available The Baba Ali skarn deposit, situated 39 km to the northwest of Hamadan (Iran, is the result of a syenitic pluton that intruded and metamorphosed the diorite host rock. Rare earth element (REE values in the quartz syenite and diorite range between 35.4 and 560 ppm. Although the distribution pattern of REEs is more and less flat and smooth, light REEs (LREEs in general show higher concentrations than heavy REEs (HREEs in different lithounits. The skarn zone reveals the highest REE-enriched pattern, while the ore zone shows the maximum depletion pattern. A comparison of the concentration variations of LREEs (La–Nd, middle REEs (MREEs; Sm–Ho and HREEs (Er–Lu of the ore zone samples to the other zones elucidates two important points for the distribution of REEs: 1 the distribution patterns of LREEs and MREEs show a distinct depletion in the ore zone while representing a great enrichment in the skarn facies neighbouring the ore body border and decreasing towards the altered diorite host rock; 2 HREEs show the same pattern, but in the exoskarn do not reveal any distinct increase as observed for LREEs and MREEs. The ratio of La/Y in the Baba Ali skarn ranges from 0.37 to 2.89. The ore zone has the highest La/Y ratio. In this regard the skarn zones exhibit two distinctive portions: 1 one that has La/Y >1 beingadjacent to the ore body and; 2 another one with La/Y < 1 neighbouring altered diorite. Accordingly, the Baba Ali profile, from the quartz syenite to the middle part of the exoskarn, demonstrates chiefly alkaline conditions of formation, with a gradual change to acidic towards the altered diorite host rocks. Utilising three parameters, Ce/Ce*, Eu/Eu* and (Pr/Ybn, in different minerals implies that the hydrothermal fluids responsible for epidote and garnet were mostly of magmatic origin and for magnetite, actinolite and phlogopite these were of magmatic origin with low REE concentration or meteoric water involved.

  18. THE EFFECTS OF THE ATTACKS TO ANATOLIA BY MEHMED ALI PASHA ON NİĞDE AND NEVŞEHİR PROVINCES

    Directory of Open Access Journals (Sweden)

    Efkan UZUN

    2012-08-01

    Full Text Available Mehmed Ali Pasha was the absolute ruler in Egypt since the Ottoman Empire was in very bad situation at that time as a result of some events. Mehmed Ali Pasha was among the soldiers sent to Egypt upon the invasion of the country by Napoleon. When his help was demanded to eliminate the rebellion in the Morea by the Sultan Mahmud the second of the Ottoman Empire, he wanted to be the governor of theMorea and the Crete Island in return for its help. However, when the Morea was taken by independent Greece in Edirne Treaty, therefore, he wanted to be the governor of Syria in place of the Morea. Sultan Mahmut the Second accepted to appoint him as the governor of the Crete Island but not Syria. As a result of this disagrement, he rebelled against the rule of The Ottoman Empire. His son, IbrahimPasha, invaded Syria with his Egyptian troops and he defeated the Ottoman army in Adana and Konya. He reached as far as Kutahya Province. The capital city, Istanbul,was in jeopardy and Sultan Mahmut the second, had to demand the aidof the Russians.When the Russian Navy reached Istanbul, England and France became worried about the situation. The domestic problem turned into an international one.The problem was solved temporarily by Kutahya Treaty signed by related states.In our study, issues related to the event such as the critical situations at that time, the worries of the people of the provinces, the technical and military support given to the empire by the provinces during Ibrahim Pasha's attacks, son of Mehmed Ali Pasha were discussed in the light of some documents and data emerged lately.The aim of the study is to introduce and discuss the event with a different aspect. Therefore, the studies about the subject done so far and documents in the archives of the empire were used. Screening model, one of the qualitative research was used in the study.

  19. Geochemistry of rare earth elements in the Baba Ali magnetite skarn deposit, western Iran - a key to determine conditions of mineralisation

    Science.gov (United States)

    Zamanian, Hassan; Radmard, Kaikosrov

    2016-03-01

    The Baba Ali skarn deposit, situated 39 km to the northwest of Hamadan (Iran), is the result of a syenitic pluton that intruded and metamorphosed the diorite host rock. Rare earth element (REE) values in the quartz syenite and diorite range between 35.4 and 560 ppm. Although the distribution pattern of REEs is more and less flat and smooth, light REEs (LREEs) in general show higher concentrations than heavy REEs (HREEs) in different lithounits. The skarn zone reveals the highest REE-enriched pattern, while the ore zone shows the maximum depletion pattern. A comparison of the concentration variations of LREEs (La-Nd), middle REEs (MREEs; Sm-Ho) and HREEs (Er-Lu) of the ore zone samples to the other zones elucidates two important points for the distribution of REEs: 1) the distribution patterns of LREEs and MREEs show a distinct depletion in the ore zone while representing a great enrichment in the skarn facies neighbouring the ore body border and decreasing towards the altered diorite host rock; 2) HREEs show the same pattern, but in the exoskarn do not reveal any distinct increase as observed for LREEs and MREEs. The ratio of La/Y in the Baba Ali skarn ranges from 0.37 to 2.89. The ore zone has the highest La/Y ratio. In this regard the skarn zones exhibit two distinctive portions: 1) one that has La/Y >1 beingadjacent to the ore body and; 2) another one with La/Y < 1 neighbouring altered diorite. Accordingly, the Baba Ali profile, from the quartz syenite to the middle part of the exoskarn, demonstrates chiefly alkaline conditions of formation, with a gradual change to acidic towards the altered diorite host rocks. Utilising three parameters, Ce/Ce*, Eu/Eu* and (Pr/Yb)n, in different minerals implies that the hydrothermal fluids responsible for epidote and garnet were mostly of magmatic origin and for magnetite, actinolite and phlogopite these were of magmatic origin with low REE concentration or meteoric water involved.

  20. Pb-Zn mineralization of Ali ou Daoud area (Central High Atlas, Morocco: characterisation of deposit and relationship with the clay assemblages

    Directory of Open Access Journals (Sweden)

    Daoudi, L.

    2008-12-01

    Full Text Available Zn-Pb-Fe ores in the Ali ou Daoud deposit (Central High Atlas are found as stratiform levels and as karst fillings in carbonate platforms facies of Bajocian age. Tectonic structures (e.g., synsedimentary faults played a relevant role in the ore emplacement. The dolomitic ore-related host-rock levels are characterized by the presence of kaolinite enrichment in clay levels in amounts directly related to the proportion of the clay minerals. The latter is evidenced by correlation between kaolinite and sulphide contents, suggesting that the installation of kaolinite and mineralisations would result from the same hydrothermal fluid.[Français] Dans les séries sédimentaires carbonatées d’Ali ou Daoud (Haut Atlas Central, les minéralisations à Zn, Pb et Fe en amas stratiformes forment les faciès de remplissage des karsts d’une plateforme carbonatée bajocienne. Le contrôle structural joue un rôle capital dans la localisation du gîte en bordure de plateforme sur des failles synsédimentaires. Dans les niveaux dolomitiques encaissants des minéralisations, les assemblages argileux sont caractérisés par la présence de kaolinite dont la teneur varie parallèlement avec celle du minerai. Ceci suggère que la mise en place de la kaolinite et des minéralisations résulterait du même fluide hydrothermal. [Español] En las series sedimentarias carbonatadas de Ali ou Daoud (Alto Atlas Central, las mineralizaciones de Zn, Pb y Fe aparecen en niveles estratiformes como facies de reemplazamiento de los karsts de una plataforma carbonatada Bajociense. El control estructural desempeña un papel crucial en la localización del yacimiento a lo largo de la plataforma sobre fallas sinsedimentarias. En los niveles dolomíticos que incluyen las mineralizaciones, las asociaciones arcillosas se caracterizan por la presencia de caolinita, cuyo contenido varía paralelamente al de la mineralización. Esto sugiere que la creación de caolinita y de la

  1. Effet des interconnexions brasées sur le signal de capteurs de force réalisés en technologie des couches épaisses

    OpenAIRE

    Maeder, Thomas; Ryser, Peter

    2002-01-01

    Ce travail présente les résultats de mesure sur des capteurs de force à poutre (cantilever), réalisés en technologie des couches épaisses et assemblés par brasure tendre Sn-Ag (Sn96). Les phénomènes de relaxation de la brasure tendre entraînent une dérive du signal de sortie des capteurs. Les résultats sont discutés en fonction de la procédure de brasage et des paramètres géométriques des capteurs (dimensions de la poutre et placement des résistances de mesure), et des recommandations p...

  2. Oferta ir akceptas kaip šalių valios sudaryti sutartį išraiška – teoriniai ir praktiniai aspektai

    OpenAIRE

    Karpickis, Kazimieras

    2011-01-01

    Šiame magistro baigiamajame darbe atskleidžiama ofertos ir akcepto, kaip asmens valios išraiškos aktų, teisinė prigimtis. Kadangi teisės doktrinoje ir teismų praktikoje oferta ir akceptas yra prilyginami vienašaliams sandoriams, darbe oferta ir akceptas yra analizuojami sandorių ir vienos iš jų rūšies, t. y. vienašalių sandorių, atžvilgiu. Pirmajame darbo skyriuje analizuojama asmens valia ir jos išraiška bei prieinama išvados, jog bendrąja prasme, nevertinant ofertos ir akcepto teisinės prig...

  3. Aliénation mentale et justice pénale : pour une histoire des représentations judiciaires

    Directory of Open Access Journals (Sweden)

    Laurence Guignard

    2009-10-01

    Full Text Available Cet article vise à montrer l'intérêt d'une étude conjointe du droit et des procédures judiciaires qui président à la production des archives. Il s'appuie sur l'exemple du traitement de la question de l'aliénation mentale des criminels par la justice pénale au xixe siècle en France et tente de saisir la logique du travail des représentations judiciaires à la croisée du droit et de la psychiatrie.This article seeks to show the interest of a joint study of the law and the judicial procedures which preside over the production of archives. It is based on the example of the treatment of the question of the insanity of the criminals by the penal justice in the XIXth century in France.

  4. The results of treating Hyaline membrane disease with Surfactant during 1 year at Ali-Asghar Hospital, neonatal intensive care unit

    Directory of Open Access Journals (Sweden)

    Naeri F

    1999-08-01

    Full Text Available The routine intake of surfactant as a part of HMD (Hyaline Membrane Disease treatment had significant effect on the prognosis of premature neonates. But since in our country this drug is not widely and routinely used, and there are not records about its use, we decided to make good on this shortcoming through a retrospective study. During 1 year, 54 neonates with HMD were admitted in Ali-Asghar's NICU, 30 of them had gestational age of less than 34 weeks and for 15 cases, surfactant was used. The results of treating this group were then compared with another group of neonates, who were not given this drug. From a statistical point of view, mortality, the length of the period in which the respirator was used, the use of high pressure in respirator, pneumothorax and pulmonary hemorrhage in neonates under treatment with surfactant was significantly less than those of the other group.

  5. Analyse statistique de l'assemblage acier/aluminium réalisé par le procédé de soudage MIG-CMT

    OpenAIRE

    Mezrag, Bachir; Benachour, Mustapha; Deschaux Beaume, Frédéric

    2014-01-01

    La dépendance vis-à-vis des paramètres de soudage de la géométrie de l'assemblage hétérogène acier/aluminium réalisé par le procédé MIG-CMT dans une configuration à clin est étudiée à travers un plan d'expérience. Les paramètres choisis comme facteurs d'influence sont la puissance de soudage, la distance entre la torche et la pièce ou "stick-out", le débit de gaz et la vitesse de soudage, tandis que les caractéristiques géométriques sélectionnées comme fonctions objectifs sont le poids de mét...

  6. Pb-Zn mineralization of the Ali ou Daoud area (Central High Atlas, Morocco): characterisation of the deposit and relationships with the clay assemblages; Mineralisation Pb-Zn du type MVT de la region d'Ali ou Daoud (Haut Atlas Central, Maroc): caracterisations du gite et relations avec les corteges de mineraux argileux

    Energy Technology Data Exchange (ETDEWEB)

    Mouguina, E. M.; Daoudi, L.

    2008-07-01

    Zn-Pb-Fe ores in the Ali ou Daoud deposit (Central High Atlas) are found as stratiform levels and as karst fillings in carbonate platforms facies of Bajocian age. Tectonic structures (e.g., syn sedimentary faults) played a relevant role in the ore emplacement. The dolomitic ore-related host-rock levels are characterized by the presence of kaolinite enrichment in clay levels in amounts directly related to the proportion of the clay minerals. The latter is evidenced by correlation between kaolinite and sulphide contents, suggesting that the installation of kaolinite and mineralizations would result from the same hydrothermal fluid. (Author) 55 refs.

  7. Geochemistry, Petrology, and Provenance of Magnetite-Rich Ortaklar Cu Deposit Hosting Basalts from Koçali Complex, Gaziantep, Turkey

    Science.gov (United States)

    Yun, E.; Lee, I.; Kang, J.; Dönmez, C.; Yildirim, N.

    2015-12-01

    Magnetite-rich Cyprus type VMS deposit has been recently discovered from the Ortaklar-Gaziantep region within Koçali complex, SE Turkey. Magnetite rich sulfide ore bodies are in close contact with underlying footwall spilitic basalts. These basalts are part of Koçali mélange, which represents an accreted oceanic complex during closing of southern Neotethys. These extrusives are low-K, low alkali tholeiites with Ca rich, partially sericitized plagioclase subophitically enclosed by augite with disseminated Fe-Ti oxides and pyrite. Mineral crystallization sequence of plagioclase followed by augite and opaque is typical of MORB. Major and trace element analyses for least altered basalts based on LOI (1.5~3.6 wt%), Ce/Ce* (0.9~1.1) exhibit limited range of element abundances. Low Mg# (59~60) suggests that basalts were derived from moderately evolved magma with fractional crystallization. HFSE (Th, Nb, Hf, Zr) were used for tectonic discrimination and basalts were plotted within MORB end spectrum, near MORB-IAT boundary. N-MORB normalized La to Lu ranges from 0.4 to 0.9 times N-MORB with LREE depletion [(La/Sm)N = 0.58~0.67] and flat HREE [(Tb/Lu)N = 0.95~1.05]. Chondrite normalized REE patterns resemble those of N-MORB but characterized by severe LREE depletion [(La/Sm)CN = 0.35~0.45]. LREE depletion coupled with high Sm/Nd (0.36~0.43), high CaO/Na2O (5.0~6.2) and low Nb/Yb (0.23~0.39) suggest depleted N-MORB composition derived from the refractory mantle source. Analyzed basalts are similar to those found from other rift (Costa Rica Rift Hole 504b) and intra-transform fault (Siqueiros transform). Magnetite emplacement occurring close to the ore-host boundary and lack of pyrrhotite from hosting basalts imply an involvement of oxidized hydrothermal fluids. Basalts probably have formed by late stage, partial melting of the refractory mantle at low pressure, shallow depth, and H2O rich environment. Possible source of mantle heterogeneity can be identified by isotope

  8. Sociological Review of Literatüre of Opportunity For Analysıs of The Ballad of Ali of Keshan

    Directory of Open Access Journals (Sweden)

    Mustafa KARABULUT

    2012-06-01

    Full Text Available Theatre, as a kind of Western modern sense began to appear in Turkish literature from the Tanzimat period on. Muhsin Ertuğrul, several authors have also grown at the initiative of the Republican era. Haldun Taner, who is an important process in the world of literature as the author replaces. He works in the works of modern and traditional elements together successfully. The author has greatly contributed to the modern Turkish theater in the formation and progression. Although many games to write Taner, Epic is known for not Pay. This works in our country, now a pioneer of epic theater, the first native, gave an instance of musical play. Haldun Taner, a critical perspective, the community The Ballad of Ali of Keshan. In this game, the conflict between urbanization and urban life, social distortions, administrators negligence, economic problems and so on. issues be heard. The author, using the power of literature, social, community life in the 1960s, offers cross-sections.

  9. Statement from the 1983 meeting of the International Commission on Radiological Protection: annual limits for intakes (ALI) and derived air concentrations (DAC) for members of the public

    International Nuclear Information System (INIS)

    The limitation of the committed effective dose equivalent for members of the public is sufficient to provide compliance over a lifetime with the limit for single organs, thus avoiding non-stochastic effects. Relative values for infants and adults of the committed dose equivalent in a number of tissues per unit intake for each of a few radionuclides have been given: the values for infants are just more than 1 up to 100 times greater than those for adult workers. In each of these cases the appropriate annual dose-equivalent limits recommended by the Commission for members of the public are 10 times less than the corresponding values for workers; the resulting ALI for infants aged six months will be smaller than the values given in ICRP Publication 30 for limiting stochastic effects in workers by factors that range from just more than 10 (for caesium-137) to 1,000 (for ingested plutonium-239). Intermediate factors would apply for older members of the public. The magnitude of the range emphasises the need to consider each situation carefully, with particular reference to children and women. (author)

  10. Structural phase stability, electronic structure and mechanical properties of alkali metal hydrides AMH4 (A=Li, Na; M=B, AL)

    Science.gov (United States)

    Santhosh, M.; Rajeswarapalanichamy, R.

    2016-01-01

    The structural stability of Alkali metal hydrides AMH4 (A=Li, Na; M=B, Al) is analyzed among the various crystal structures, namely hexagonal (P63mc), tetragonal (P42/nmc), tetragonal (P-421c), tetragonal (I41/a), orthorhombic (Pnma) and monoclinic (P21/c). It is observed that, orthorhombic (Pnma) phase is the most stable structure for LiBH4, monoclinic (P21/c) for LiAlH4, tetragonal (P42/nmc) for NaBH4 and tetragonal (I41/a) for NaAlH4 at normal pressure. Pressure induced structural phase transitions are observed in LiBH4, LiAlH4, NaBH4 and NaAlH4 at the pressures of 4 GPa, 36.1 GPa, 26.5 GPa and 46 GPa respectively. The electronic structure reveals that these metal hydrides are wide band gap insulators. The calculated elastic constants indicate that these metal hydrides are mechanically stable at normal pressure.

  11. UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.

    Science.gov (United States)

    Hautbergue, Guillaume M; Hung, Ming-Lung; Walsh, Matthew J; Snijders, Ambrosius P L; Chang, Chung-Te; Jones, Rachel; Ponting, Chris P; Dickman, Mark J; Wilson, Stuart A

    2009-12-01

    Messenger RNA (mRNA) export adaptors play an important role in the transport of mRNA from the nucleus to the cytoplasm. They couple early mRNA processing events such as 5' capping and 3' end formation with loading of the TAP/NXF1 export receptor onto mRNA. The canonical adaptor REF/ALY/Yra1 is recruited to mRNA via UAP56 and subsequently delivers the mRNA to NXF1 [1]. Knockdown of UAP56 [2, 3] and NXF1 [4-7] in higher eukaryotes efficiently blocks mRNA export, whereas knockdown of REF only causes a modest reduction, suggesting the existence of additional adaptors [8-10]. Here we identify a new UAP56-interacting factor, UIF, which functions as an export adaptor, binding NXF1 and delivering mRNA to the nuclear pore. REF and UIF are simultaneously found on the same mRNA molecules, and both proteins are required for efficient export of mRNA. We show that the histone chaperone FACT specifically binds UIF, but not REF, via the SSRP1 subunit, and this interaction is required for recruitment of UIF to mRNA. Together the results indicate that REF and UIF represent key human adaptors for the export of cellular mRNAs via the UAP56-NXF1 pathway.

  12. Crystal structures of hydrates of simple inorganic salts. III. Water-rich aluminium halide hydrates: AlCl3 · 15H2O, AlBr3 · 15H2O, AlI3 · 15H2O, AlI3 · 17H2O and AlBr3 · 9H2O.

    Science.gov (United States)

    Schmidt, Horst; Hennings, Erik; Voigt, Wolfgang

    2014-09-01

    Water-rich aluminium halide hydrate structures are not known in the literature. The highest known water content per Al atom is nine for the perchlorate and fluoride. The nonahydrate of aluminium bromide, stable pentadecahydrates of aluminium chloride, bromide and iodide, and a metastable heptadecahydrate of the iodide have now been crystallized from low-temperature solutions. The structures of these hydrates were determined and are discussed in terms of the development of cation hydration spheres. The pentadecahydrate of the chloride and bromide are isostructural. In AlI(3) · 15H2O, half of the Al(3+) cations are surrounded by two complete hydration spheres, with six H2O in the primary and 12 in the secondary. For the heptadecahydrate of aluminium iodide, this hydration was found for every Al(3+).

  13. A comparison between HfO2/Al2O3 nano-laminates and ternary HfxAlyO compound as the dielectric material in InGaAs based metal-oxide-semiconductor (MOS) capacitors

    Science.gov (United States)

    Krylov, Igor; Pokroy, Boaz; Eizenberg, Moshe; Ritter, Dan

    2016-09-01

    We compare the electrical properties of HfO2/Al2O3 nano-laminates with those of the ternary HfxAlyO compound in metal oxide semiconductor (MOS) capacitors. The dielectrics were deposited by atomic layer deposition on InGaAs. Water, ozone, and oxygen plasma were tested as oxygen precursors, and best results were obtained using water. The total dielectric thickness was kept constant in our experiments. It was found that the effective dielectric constant increased and the leakage current decreased with the number of periods. Best results were obtained for the ternary compound. The effect of the sublayer thicknesses on the electrical properties of the interface was carefully investigated, as well as the role of post-metallization annealing. Possible explanations for the observed trends are provided. We conclude that the ternary HfxAlyO compound is more favorable than the nano-laminates approach for InGaAs based MOS transistor applications.

  14. Low-Cost Evaluation of EO-1 Hyperion and ALI for Detection and Biophysical Characterization of Forest Logging in Amazonia (NCC5-481)

    Science.gov (United States)

    Asner, Gregory P.; Keller, Michael M.; Silva, Jose Natalino; Zweede, Johan C.; Pereira, Rodrigo, Jr.

    2002-01-01

    quantify both the presence and degree of structural disturbance caused by various logging regimes. Our quantitative assessment of Hyperion hyperspectral and ALI multi-spectral data for the detection and structural characterization of selective logging in Amazonia will benefit from data collected through an ongoing project run by the Tropical Forest Foundation, within which we have developed a study of the canopy and landscape biophysics of conventional and reduced-impact logging. We will add to our base of forest structural information in concert with an EO-1 overpass. Using a photon transport model inversion technique that accounts for non-linear mixing of the four biogeophysical indicators, we will estimate these parameters across a gradient of selective logging intensity provided by conventional and reduced impact logging sites. We will also compare our physical ly-based approach to both conventional (e.g., NDVI) and novel (e.g., SWIR-channel) vegetation indices as well as to linear mixture modeling methods. We will cross-compare these approaches using Hyperion and ALI imagers to determine the strengths and limitations of these two sensors for applications of forest biophysics. This effort will yield the first physical ly-based, quantitative analysis of the detection and intensity of selective logging in Amazonia, comparing hyperspectral and improved multi-spectral approaches as well as inverse modeling, linear mixture modeling, and vegetation index techniques.

  15. Study of the growth, reproductive biology and abundance for invasive shrimpsPalaemon elegans Rathke from Garmat Ali river Basrah, Southern Iraq

    Institute of Scientific and Technical Information of China (English)

    Khaled Khasaf Al-Khafaji; Imad Hadi Al Qarooni; Murtatha Youssef Al Abbad; Nada Moffed Abd Al-Lateef

    2016-01-01

    Objective:To describe the growth, reproductive biology and abundance of the population of invasive shrimpsPalaemon elegans (P. elegans) in one of the branches of Garmat Ali river at Basrah, Southern Iraq. Methods:Monthly samples of the prawnP. elegans were collected with a bottom hand net (40 cm, 0.5 mm mesh) hauled over a distance of 10 m. A simple random sampling was conducted monthly between December 2012 and November 2013. Results:Seasonal changes were observed in the composition of the population of the species during the study year with the highest abundance in 2013 and the lowest abundance for the males was reported in January and for the females occurred in June. Salinity showed a significant correlation with the abundance of shrimps at the sampling site. The largest female measured 67.90 mm while the corresponding value for males was 61.31 mm. The proportion of ovigerous adults rose during spring season to peak on about July and ovigerous prawns were taken in all months of the year. The sex ratio indicated a preponderance of females over males in all months in the study period. Each females produced around 36–1 324 eggs and the incubation period lasted for 11–14 days at 17–29°C. Conclusions:The results of the present study indicate that this species has a wide distribution range, high density, and great reproduction potential. This study reveals the lack of researches on this species in environments of Shatt Al-Arab river and its branches. Thus,P. elegans has most likely formed a permanent population in all the brackish waters in Basrah area.

  16. Survey of characteristics of neonatal death in neonatal intensive care unit of Boo-Ali Sina educational & therapeutic center between 2003-2006

    Directory of Open Access Journals (Sweden)

    Azita Bala Ghafari

    2009-01-01

    Full Text Available , , , (Received 24 June, 2009 ; Accepted 16 September, 2009AbstractBackground and purpose: The neonatal mortality rate is an important index for evaluation of public health. It involves the death of infants under 28 days. Obviously, recognizing the characteristics of neonatal mortality in this center, may be useful for promoting the procedures in the NICU, as well as planning to impede the severe complications or death.Materials and methods: This is a descriptive study performed by analyzing the available data from the medical records of NICU patients at Boo-Ali Sina Educational & Therapeutic Center during 2003 and 2006. The number of deaths, names, and medical records number of the dead infants were collected. Among 1238 patients in the NICU, 363 deaths were reported. According to medical records, 222 deaths occurred in neonates aged 0 to 27 days. Data were collected using a checklist, the validity and reliability of which were approved by clinicians. The Descriptive methods were used in analyzing the data.Results: The findings include: 140 subjects were male (63.1%; 72 from single birth (77.5%; the age-group of mothers of 38 cases (37.7% was 20-24 y; 132 cases (59.5% resided in villages; 129 cases (58.1% with prenatal care; 120 cased of Caesarian section (54%; 155 cases (76% with birth weight lower than 2500 grams and 154 preterm (75.5%. Mortality during neonatal period was divided in two groups: early death (0-6 days 142 cases (62% and late death (7-27 days 80 cases (36%.Conclusion: Correct and exact completion of NICU forms would help undertaking descriptive and analytic epidemiologic studies.Key words: Neonatal mortality, early neonatal mortality, late neonatal mortality, NICUJ Mazand Univ Med Sci 2009; 20(74: 79-83 (Persian

  17. Development of Antisense Therapeutic and Imaging Agents to Detect and Suppress Inducible Nitric Oxide Synthase (iNOS) Expression in Acute Lung Injury (ALI)

    Science.gov (United States)

    Shen, Yuefei

    This dissertation focuses on the development and investigation of antisense imaging and therapeutic agents, combined with nanotechnology, to detect and suppress inducible nitric oxide synthase (iNOS) expression for the diagnosis and treatment of acute lung injury (ALI). To achieve this goal, several efforts were made. The first effort was the identification and characterization of high binding affinity antisense peptide nucleic acids (PNAs) and shell-crosslinked knedel-like nanoparticle (SCK)-PNA conjugates to the iNOS mRNA. Antisense binding sites on the iNOS mRNA were first mapped by a procedure for rapidly generating a library of antisense accessible sites on native mRNAs (MASL) which involves reverse transcription of whole cell mRNA extracts with a random oligodeoxynucleotide primer followed by mRNA-specific PCR. Antisense PNAs against the antisense accessible sites were accordingly synthesized and characterized. The second effort was the investigation of cationic shell crosslinked knedel-like nanoparticle (cSCK)-mediated siRNA delivery to suppress iNOS expression for the treatment of ALI. siRNA with its unique gene-specific properties could serve as a promising therapeutic agent, however success in this area has been challenged by a lack of efficient biocompatible transfection agents. cSCK with its nanometer size and positive charge previously showed efficient cellular delivery of phosphorothioate ODNs (oligodeoxynucleotides), plasmid DNA and PNA. Herein, cSCK showed good siRNA binding and facilitated efficient siRNA transfection in HeLa, a mouse macrophage cell line and other human cell lines. cSCK led to greater silencing efficiency than Lipofectamine 2000 in HeLa cells as determined by the viability following transfection with cytotoxic and non-cytotoxic siRNAs, as well in 293T and HEK cells, and was comparable in BEAS-2B and MCF10a cells. The third effort was the preparation of an iNOS imaging probe through electrostatic complexation between a radiolabeled

  18. Clinical significance of PCT in exhaled breath condensate and serum of patients with acute lung injury/acute respiratory distress syndrome%ALI/ARDS患者呼出气冷凝液和血清中PCT检测及其临床意义

    Institute of Scientific and Technical Information of China (English)

    陈金亮; 陈建荣; 薛垒喜; 陶一江; 陶国华

    2015-01-01

    目的:研究ALI/ARDS患者呼出气冷凝液( EBC)和血清中降钙素原( PCT)的变化规律,探讨PCT在ALI/ARDS诊断、病情评估、预后判断中的临床意义。方法选择行机械通气的ALI/ARDS患者33例;同时选择20例健康体检者为健康对照组。观察ALI/ARDS患者与健康对照组之间血清和EBC中PCT的差异,分析临床指标和各种指标之间的相关性。结果①ALI/ARDS组EBC和血清中PCT高于健康对照组。②ARDS组患者第七天EBC和血清中PCT中PCT高于ALI组。③存活组患者治疗后EBC和血清中PCT水平下降,病死组患者EBC和血清中PCT持续升高。④EBC和血清中PCT与PaO2/FiO2、APACHEⅡ有相关性。结论 ALI/ARDS患者EBC和血清中PCT的检测,有助于ALI/ARDS的诊断、病情评估和判断预后。%Objective To detect the change of procalcitonin ( PCT) in exhaled breath condensate ( EBC) and serum of ALI/ARDS patients and to explore its clinical significance in diagnosis, illness evaluation and progno-sis. Methods The study selected 33 mechanical ventilation patients with ALI/ARDS as the observation group and 20 healthy people as the control group. The difference of PCT in EBC and serum was compared between the two groups, and the correlation among the clinical indicators was analyzed. Results ①The level of PCT in EBC and se-rum was higher in the observation group than in the control group. ②The level of PCT was higher in the ARDS group than in the ALI group on the seventh day. ③The level of PCT decreased in the survival group after treatment, but it increased in the death group. ④ The level of PCT in EBC and serum was associated with PaO2/FiO2 and APACHE Ⅱ. Conclusion The test of PCT in EBC and serum of ALI/ARDS patients can contribute to their diagnosis, condi-tion evaluation and prognosis.

  19. Tunable deep ultraviolet femtosecond sum frequency laser based on Ba1-xB2-y-zO4SixAlyGaz crystal%Ba1-xB2-y-z O4SixAly Gaz晶体和频可调谐深紫外飞秒激光器∗

    Institute of Scientific and Technical Information of China (English)

    孟祥昊; 刘华刚; 黄见洪; 戴殊韬; 邓晶; 阮开明; 陈金明; 林文雄

    2015-01-01

    Tunable coherent deep ultraviolet (DUV) light sources, especially ultrashort pulse DUV lasers have great appli-cations in the fields of time-resolved, material processing, spectroscopy, laser spectroscopy and laser fusion. In the UV region, the best choice of generating the laser pulses in the femtosecond or picosecond regime is the frequency up-conversation technique based on second order nonlinearities. Over the past three decades, quite a lot of nonlinear crystals, such as LiB3O5, β-BaB2O4, KBe2BO3F2 and Ba1−xB2−y−zO4SixAlyGaz have been developed and employed for gener-ating the femtosecond pulses in the blue, ultraviolet, and even the deep-ultraviolet region. A tunable deep ultraviolet femtosecond laser is experimentally studied based on the new nonlinear crystal Ba1−xB2−y−zO4SixAlyGaz It is a kind of low-temperature phase barium metaborate single crystal belonging to a trigonal system, doped with one or more elements selected from Si, Al and Ga. As an optimized β-BaB2O4 crystal, Ba1−xB2−y−zO4SixAlyGaz completely overcomes the shortcomings of deliquescence compared withβ-BaB2O4, and its nonlinear efficiency and optical damage threshold have also been greatly improved. Using two crystals as second harmonic generation is to compensate for the spatial walk-off effect and the light path walk-off due to refraction effect The optical axis of the second Ba1−xB2−y−zO4SixAlyGaz is twice the phase matching angle with respect to the first one. In a femtosecond regime, short pulse provides high efficient frequency conversation due to their high peak powers, but the group velocity mismatch is a cognitive factor to limit conversion efficiency. It is obvious that after the frequency doubling, the second harmonic pulse and fundamental pulse separate from each other. The second harmonic pulse lags behind the fundamental pulse as they propagate through the crystal and the second harmonic pulse is broadened into a longer pulse duration than the

  20. Unustatud katakombid / Claudia Haj Ali

    Index Scriptorium Estoniae

    Haj Ali, Claudia

    1999-01-01

    Arheoloog Jean-Yves Empereur leidis Egiptuse Aleksandria linna lähedal asuvasse kaljusse rajatud katakombid, mis on osa hellenistlikul perioodil rajatud ning pikka aega unustuse hõlmas olnud surnute linnast. Leidude seas on kipsist Meduusa pea nind leide Rooma perioodist.

  1. A new myxosporean species Myxobolus sclerii sp. nov. and one known species M. stomum Ali et al. 2003 from two Indian major carp fishes.

    Science.gov (United States)

    Kaur, Harpreet; Singh, Ranjeet

    2010-04-01

    The present communication deals with description of one new species of Myxobolus (Myxozoa: Myxosporea: Bivalvulida), M. sclerii sp. nov. infecting eye ball of Catla catla (Hamilton) and redescription of M. stomum infecting scales of Labeo rohita (Hamilton), two major carps of Kanjali and Ropar Wetlands respectively. Spores of M. sclerii sp. nov. measure 7.9-9.5(8.7 ± 1.13) × 4.3-5.7(5 ± 0.98) μm in size. Parietal folds absent. Polar capsules two, equal and measuring 4-5.4(4.7 ± 0.98) × 1-2.6(1.8 ± 1.31) μm in size. A rod-shaped medium-sized intercapsular process is present. Iodinophilous vacuole present measuring 2.19-4.13(3.16 ± 1.37) μm in diameter. Spores of M. stomum Ali et al.2003 measure 9.8-10.3(10.0 ± 0.35) × 7.9-8.7(8.3 ± 0.56) μm in size, with rounded anterior and posterior end. Spore valves smooth, symmetrical, thick measuring 0.88 μm in thickness. Parietal folds absent. Two anteriorly situated polar capsules are equal, pear-shaped measuring 4.8-5.2(5.0 ± 0.28) × 1.5-2.3(1.9 ± 0.56) μm in size, each with a neck leading to a fine duct opening independently. Both polar capsules converge slightly anteriorly but diverge apart posteriorly occupying more than half of spore body. Intercapsular appendix is absent. Earlier, the parasite was recorded in the buccal cavity, muscles and lips of Plectorhynchus gaterinus (Forsskal), Egypt. A new locality-Ropar Wetland, a new location-scales and a new host- Labeo rohita (Hamilton) are recorded for this parasite. PMID:21526031

  2. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali: Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology

    Directory of Open Access Journals (Sweden)

    Shaheed Ur Rehman

    2016-03-01

    Full Text Available Eurycoma longifolia Jack (known as tongkat ali, a popular traditional herbal medicine, is a flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and also Cambodia, Myanmar, Laos and Thailand. E. longifolia, is one of the well-known folk medicines for aphrodisiac effects as well as intermittent fever (malaria in Asia. Decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever. Mostly, the roots extract of E. longifolia are used as folk medicine for sexual dysfunction, aging, malaria, cancer, diabetes, anxiety, aches, constipation, exercise recovery, fever, increased energy, increased strength, leukemia, osteoporosis, stress, syphilis and glandular swelling. The roots are also used as an aphrodisiac, antibiotic, appetite stimulant and health supplement. The plant is reported to be rich in various classes of bioactive compounds such as quassinoids, canthin-6-one alkaloids, β-carboline alkaloids, triterpene tirucallane type, squalene derivatives and biphenyl neolignan, eurycolactone, laurycolactone, and eurycomalactone, and bioactive steroids. Among these phytoconstituents, quassinoids account for a major portion of the E. longifolia root phytochemicals. An acute toxicity study has found that the oral Lethal Dose 50 (LD50 of the alcoholic extract of E. longifolia in mice is between 1500–2000 mg/kg, while the oral LD50 of the aqueous extract form is more than 3000 mg/kg. Liver and renal function tests showed no adverse changes at normal daily dose and chronic use of E. longifolia. Based on established literature on health benefits of E. longifolia, it is important to focus attention on its more active constituents and the constituents’ identification, determination, further development and most

  3. Centennial-scale vegetation and climate changes in the Middle Atlas, Morocco: new insights from multi-proxy investigations at Lake Sidi Ali

    Science.gov (United States)

    Fletcher, William; Campbell, Jennifer; Joannin, Sebastien; Mischke, Steffen; Zielhofer, Christoph; de Batist, Marc; Mikdad, Abdes

    2016-04-01

    The karstic lakes of the Middle Atlas, Morocco, represent a valuable archive of environmental and climatic change for Northwest Africa. Here we present the results of centennial-scale palynological and charcoal analyses as part of a multiproxy palaeolimnological study of sediment cores from Lake Sidi Ali in the Middle Atlas, Morocco (33° 03 N, 05° 00 W; 2,080 m a.s.l.). Supported by absolute dating including 23 more than twenty AMS 14C dates on pollen concentrates, the record covers the entire Holocene and offers insights into vegetation and climate change at a regionally unprecedented centennial-scale. Pollen assemblages are dominated by steppic herbs, evergreen oaks (Quercus), junipers (Cupressaceae) and Atlantic cedar (Cedrus atlantica). A long-term evolution of the montane vegetation is recorded, reflecting progressive changes in the dominant arboreal taxa and leading to the full establishment of the emblematic cedar forests of the area during the mid-Holocene by 6000 cal BP. Orbital-scale changes in seasonality and growing season moisture availability linked to declining summer insolation are implicated, with a transition from (a) warm, dry summers associated with summer drought tolerant taxa especially evergreen Quercus, high algal productivity in the lake, and high background levels of microcharcoal reflecting distant fire activity during the early Holocene, to (b) cool, relatively humid summers with dominance of montane conifers, declining algal productivity in the lake, and episodic local fire activity during the mid- to late Holocene. Superimposed on the long-term environmental changes are recurrent centennial-scale fluctuations in vegetation composition, reflecting competitive dynamics between the major taxa, initially between steppic and arboreal elements, and later between the major tree taxa. Parallels with hydrological proxies including stable O and C isotopes suggest common responses to climatic drivers (fluctuations in moisture sources and

  4. Le champ critique de claquage de films d'oxyde de polyphénylène réalisés par voie électrochimique

    Science.gov (United States)

    Adohi, B.; Gosse, J. P.; Gosse, B.

    1991-10-01

    The electrical breakdown of thin films of polyphenylene oxide electrochemically deposited on stainless steel plane substrates has been studied. First it was examined the dependence of the medium surrounding the dielectric and the electrodes (nature, hydrostatic pressure) on the breakdown voltage and on its statistical distribution. Between sphere and plane electrodes, it appears that even for pressurified gases, breakdown of the film is caused by the gas breakdown. We have analysed the discharges occurring at atmosphere pressure in the test cell. Breakdown of the film occurred when the electric field due to the charge deposited on its surface was about 230 V/μm. We have also studied self-healing capacitors with PPO as a dielectric, and determined the life-time of this material. On a étudié le claquage électrique de films minces d'oxyde de polyphénylène de quelques microns d'épaisseur déposés par voie électrochimique sur un plan en acier inoxydable. L'étude a d'abord été faite en rampe de tension continue dans la géométrie d'électrodes sphèreplan, en fonction du milieu ambiant liquide ou gazeux. L'influence de la pression sur la rigidité diélectrique du matériau, les distributions statistiques de Weibull et les cratères formés au moment du claquage, dans les différents milieux et dans les deux polarités de l'électrode sphérique montrent que le claquage du matériau est causé par des décharges qui se produisent dans le milieu environnant. A partir de l'analyse quantitative de ces décharges, on propose comme critère de caractérisation de la rupture d'un matériau sounmis aux décharges, le champ créé au moment de la rupture par les charges déposées à sa surface. On a réalisé ensuite des échantillons plans > par dépôt de couches minces d'aluminium (quelques milliers d'Å d'épaisseur) sur le film de PPO. On étudie dans cette configuration la durée de vie du matériau.

  5. Erken Cumhuriyet Yılları Milli Kimlik Tartışmaları: Hasan Ali Yücel ve Türkiye’de Hümanizma Arayışları Discussions on National Identity in the Early Republican Years: Hasan Ali Yucel and Searching for Turkish Humanism

    Directory of Open Access Journals (Sweden)

    Emre YILDIRIM

    2013-09-01

    Full Text Available This article aims to demonstrate a small group of intellectuals’ thoughts on nationalism and Turkish national identity who had tried to give an answer by searching for a new and unique Turkish humanism in general and particularly former Minister of Education, Hasan Ali Yücel’s period (1939-1946 and his humanist reformist approach to politics during the nation/identity-building process in the early decades of Republican Era. After the historical and social transition, French Revolution spreading the ideas of equality, liberty and fraternity giving rise to nationalist movements throughout Europe ended up with the decline of the multi-national empires and gave birth to the nation-states. Like the others, a new nation-state, Turkish Republic was established after the Ottoman Empire had collapsed. Turkish modernization initially took a form of westernization. Three ideologies; Pan-Ottomanism, Pan-Islamism and Pan-Turkism were seen as an appropriate direction for the society’s search for a new identity. At the same time, Turkish national identity was seen as an appropriate direction for the society’s search for a new identity and The republican elite embarked a radical stand and defined Turkish identiy as western modern secular nation which later became a dominant ideology for the new republic. At the time of early years of Republic, there were seen different acceptions for the content national identity. Hasan Ali Yücel and intellectuals searching for Turkish humanism defined modern Turkish identity by deriving it from Anatolian humanism, which could be realized through a Turkish Renaissance and claimed that it would be possible to create a unique Anatolian identity by this definition. Bu çalışma, Modern Türkiye tarihinin erken Cumhuriyet yıllarının ulus-devletleşme sürecinde milliyetçilik ve milli kimlik üzerine yaşanan tartışmalara katkıları açısından milli kimliğin içeriğini belirlemede Türkiye’ye özgü yeni bir

  6. Spectroscopic Characterization of GaAs and AlxGa1 – xAs / AlyGa1 – yAs Quantum Well Heterostructures

    Directory of Open Access Journals (Sweden)

    Mirgender Kumar

    2013-07-01

    Full Text Available This work presents the results of the characterization of GaAs and AlxGa1 – xAs / AlyGa1 – yAs quantum well hetero-structures growth by MOVPE system. The main goal is to explore the ability of characterization techniques for multilayer structures like quantum wells. The characterization was performed using photoreflectance spectroscopy, surface photovoltaic spectroscopy and X-ray diffraction. The experimental results are verified by numerical simulation.

  7. Akçali Emel, Chypre : un enjeu géopolitique actuel, Paris : L’Harmattan, (Collect. Histoire et perspectives méditerranéennes, 2010, 356 p.

    Directory of Open Access Journals (Sweden)

    Gérard Groc

    2011-05-01

    Full Text Available L’étude de E. Akçali est un travail très intéressant car fourni et diversifié, bâti à partir d’une problématique complexe et qui tend à renseigner sur de nombreux aspects de la question. À côté de la dimension analytique, cette dimension informative du travail est immédiatement à souligner. Le titre en est, certes, Chypre, un enjeu géopolitique… mais autant l’introduction que la quatrième de couverture lui préfèrent le terme de « question chypriote », ce qui me semble bien être le véritable o...

  8. Retraction: "Inactivation of Ink4a/Arf Leads to Deregulated Expression of miRNAs in K-Ras Transgenic Mouse Model of Pancreatic Cancer" by Ali et al.

    Science.gov (United States)

    2016-10-01

    The above article, published online on June 21, 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figure 5A to be inappropriately manipulated. Literature Cited Ali S, Banerjee S, Logna F, Bao B, Philip PA, Korc M, Sarkar FH. 2012. Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer. J Cell Physiol 227:3373-3380; doi: 10.1002/jcp.24036. PMID:27315161

  9. Retraction: "Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer" by Ali et al.

    Science.gov (United States)

    2016-08-01

    The above article, published online on March 8, 2010 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figures 2A, 4, 6A, and 6C to be inappropriately manipulated. REFERENCE Ali S, Banerjee S, Schaffert JM, El-Rayes BF, Philip PA, Sarkar FH. 2010. Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer. J Cell Biochem 110:171-181; doi: 10.1002/jcb.22523.

  10. Retraction: "Inactivation of Ink4a/Arf Leads to Deregulated Expression of miRNAs in K-Ras Transgenic Mouse Model of Pancreatic Cancer" by Ali et al.

    Science.gov (United States)

    2016-10-01

    The above article, published online on June 21, 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figure 5A to be inappropriately manipulated. Literature Cited Ali S, Banerjee S, Logna F, Bao B, Philip PA, Korc M, Sarkar FH. 2012. Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer. J Cell Physiol 227:3373-3380; doi: 10.1002/jcp.24036.

  11. İslam Dünyasının İlk Tıp Ansiklopedisi Firdevsü'l-Hikme ve Müellifi ?Ali b. Sehl Rabban Taberi: Hayatı ve Eserleri

    Directory of Open Access Journals (Sweden)

    Salim Aydüz

    2013-01-01

    Full Text Available As a physician, scientist and philosopher, ‘Alī b. Sahl Rabbān al-Ṭabarī was the son of Sahl Sahl Rabbān al-Ṭabarī. ‘Ali was born in the educated and intellectual Christian family. He wrote many books on philosophy, medicine and religious matters. Particularly, his Firdaws al-ḥikma is the first ever written medical encyclopaedia which incorporates all the branches of the medical sciences. This article demonstrates how important ‘Alī b. Sahl al-Ṭabarī’s contribution was significant in Muslim heritage in terms of philosophical, religious and medicinal works. A rich bibliography backs the arguments of the articles and provides a solid basis for further reading.

  12. Recherches sur les biocénoses céréalières. I. - Incidence à long terme des rotations maïs-blé sur les niveaux de populations d’insectes ravageurs

    OpenAIRE

    Chambon, Jean-Pierre

    1982-01-01

    La connaissance des biocénoses est la base écologique indispensable pour comprendre le fonctionnement des agrosystèmes, pour apprécier les répercussions des interventions phytosanitaires et les aménager rationnellement. De 1974 à 1980, l’évolution des populations d’insectes a été étudiée dans les cultures céréalières du Bassin parisien par des techniques de piégeage qui ont permis de mettre en évidence l’abondance et la complexité de la faune entomologique des milieux céréaliers. Cette ...

  13. Retraction: "Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer" by Ali et al.

    Science.gov (United States)

    2016-08-01

    The above article, published online on March 8, 2010 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figures 2A, 4, 6A, and 6C to be inappropriately manipulated. REFERENCE Ali S, Banerjee S, Schaffert JM, El-Rayes BF, Philip PA, Sarkar FH. 2010. Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer. J Cell Biochem 110:171-181; doi: 10.1002/jcb.22523. PMID:27301888

  14. 维生素E对LPS诱导的急性肺损伤中氧化应激的影响%Effect of Vitamin E on oxidative stress of LPS-induced ALI

    Institute of Scientific and Technical Information of China (English)

    张天杰; 李雪飞

    2013-01-01

      目的:探讨维生素E对脂多糖(lipopolysaccharide,LPS)诱导的急性肺损伤(acute lung injury,ALI)中氧化应激状态的影响。方法:以Wistar大鼠为研究对象,实验分成正常对照组、ALI组及维生素E预处理组。用LPS作用于大鼠6 h后检测各组大鼠肺组织中丙二醛(Malondialdehyde,MDA)的含量、乳酸脱氢酶(lactate dehydroge-nase,LDH)及超氧化物歧化酶(superoxide dismutase,SOD)活性,并应用RT-PCR及ELISA法检测大鼠肺组织中TNF-α的水平。结果:ALI组与正常对照组比较SOD活性下降、LDH的活性增强、MDA的含量升高,且TNF-αmRNA 及蛋白的表达增加(P﹤0.05);维生素E预处理组与ALI组比较SOD活性增强,LDH的活性减弱, MDA的含量降低,TNF-αmRNA 及蛋白的表达降低(P﹤0.05)。结论:维生素E预处理可减轻LPS诱导的ALI大鼠肺组织的脂质过氧化损伤,减少炎症因子的表达,发挥一定的抗损伤效应。%Objective To explore the effect of vitamin E on oxidative stress of lipopolysaccharide (LPS) in-duced acute lung injury (ALI).Methods Wistar rats as the research object, the experiment is divided into normal group, ALI group and vitamin E pretreatment group. After LPS treat rats on 6 hours,MDA content, LDH and SOD activity in the lung tissue were detected, RT-PCR and ELISA were used to detect TNF-αexpression of lung.Re-sults ALI groups activity of SOD decreased, activity of LDH strengthen,content of MDA increased and TNF alpha mRNA and protein expression increased compared with normal groups (P﹤0.05).Vitamin E pretreatment groups activity of SOD strengthen, activity of LDH abated, content of MDA reduced, and TNF alpha mRNA and protein expression reduced compared with LPS groups (P﹤0.05).Conclusion Vitamin E pretreatment can reduce lipid peroxidation damage and inflammatory factor expression of lung tissue in LPS-induced ALI, playing against-in-jury effect.

  15. Hasan Ali Toptaş'ın Kayıp Hayaller Kitabı'nda Büyülü Gerçekçilik In Kayıp Hayaller Kitabı of Hasan Ali Toptaş Megical Realism

    Directory of Open Access Journals (Sweden)

    Oktay YİVLİ

    2013-09-01

    Full Text Available In narrations of magical reality, real and unreal, ordinary andextraordinary, authentic and imaginary elements exist together withoutany conflict. Magical Realism flourishes especially in the twentiethcentury Latin American Literature. This sense results from the struggleof comprehending and narrating new reality as opposed to fantasticfictions and tales. In his novel called Kayıp Hayaller Kitabı, Hasan AliToptaş included the techniques and elements used in the samples ofmagical realism, such as de-familiarization, singularity, indefiniteness,dead people and multiple narrators.As be different fantastic in magical realism fictional people havebeen to become inured to in a world which is together realty and magic,just about accepted it as a natural media. Formal notice of magicalrealism from fantastic is that it selects spaces from realty world notimaginary world.In his novel called Kayıp Hayaller Kitabı, external reality isn’talways reflected one to one. The narration differentiates from classicnarrative structure reality in terms of presentations. Event descriptionsseen, heard and dreamed are presented in an imaginary order. In thenovel, the nature of entities and objects are given as changed Thus ittries to catch to catch another dimension of reality. The people in thenovel doubt from their own realities. What is real, what is not realbecome confused.After all these features, the novel studied should be considered asa magical realistic novel and should be evaluated as use aesthetics ofmagical realism. Büyülü gerçekçi anlatılarda gerçekle gerçek dışı, olağanla olağan olmayan, düşsel ile sahici ögeler aynı dünyanın içinde herhangi bir çatışmaya girmeden yaşarlar. Büyülü gerçekçilik özellikle yirminci yüzyıl Latin Amerikan edebiyatında gelişip serpilmiştir. Bu anlayış fantastikten ve masaldan ayrı olarak yeni gerçekliği kavramanın ve anlatmanın bir çabası olarak ortaya çıkmıştır. Hasan Ali

  16. 27 August 2013 - Signature of an Agreement between KTO Karatay University in Turkey represented by the Dean of Engineering Professor Ali Okatan, CERN represented by Director for Research and Computing Dr Sergio Bertolucci and ALICE Collaboration represented by ALICE Collaboration Spokesperson Dr Paolo Giubellino.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    27 August 2013 - Signature of an Agreement between KTO Karatay University in Turkey represented by the Dean of Engineering Professor Ali Okatan, CERN represented by Director for Research and Computing Dr Sergio Bertolucci and ALICE Collaboration represented by ALICE Collaboration Spokesperson Dr Paolo Giubellino.

  17. The randomized, controlled trials for treatment of ALI/ARDS by enteral nutrition with EPA and GLA%多不饱和脂肪酸肠内营养治疗急性肺损伤/急性呼吸窘迫综合征

    Institute of Scientific and Technical Information of China (English)

    罗亮

    2011-01-01

    多不饱和脂肪酸(PUFA)富含二十碳五烯酸(EPA)和γ-亚麻酸(GLA),治疗急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)是近年来的又一进展.迄今为止,EPA+GLA的肠内营养(EN)制剂用于ALI/ARDS治疗的前瞻性、随机、双盲对照试验已有四项.其结论显示,EPA+GLA的EN治疗ALI/ARDS,有助于早期改善病人的氧合情况和缩短机械通气时间,同时改善呼吸力学情况、缩短ICU入住时间、减少新发器官功能衰竭以及改善生存等.EPA+GLA的EN治疗ALUARDS的临床随机对照试验结果仍存在异质性和局限性,需要进一步大型随机对照临床试验.%Polyunsaturated fatty acid has been used in clinical setting for a long time. Now, an advancement has been achieved in the adjuvant treatment of acute lung injury (ALI) or acute respiratory distress syndrome(ARDS) by enteral nutrition with eicosapentaenoic acid (EPA)and gamma-linolenic acid (GLA). Up to now, four prospective, randomized, double-blind, controlled clinical trials have been completed, which concentrated its' attention on the therapeutic effect of enteral nutrition with EPA and GLA on ALI/ARDS. These results showed that nutrition therapy with EPA and GLA could improve oxygenation and reduce the requirement of ventilation. However, the heterogeneity of results and the limitation of studies really exits, which need large scale randomized, controlled clinical trial .

  18. Le diagnostic anténatal de la trisomie 21 par l'hybridation in situ en fluorescence (FISH): à propos des premiers tests réalisés au Maroc

    Science.gov (United States)

    Lamzouri, Afaf; Natiq, Abdelhafid; Tajir, Mariam; Sendid, Mohamed; Sefiani, Abdelaziz

    2012-01-01

    Introduction Le but de cette étude était de présenter les premiers résultats de diagnostic anténatal de la trisomie 21 par la technique d'hybridation in situ en fluorescence (FISH) au Maroc et discuter son intérêt dans le diagnostic rapide de cette aneuploïdie. Méthodes Ce travail a été réalisé chez 23 femmes avec des grossesses à haut risque de trisomie 21. La moyenne d’âge des gestantes étaient de 37,43 ans avec des extrêmes de 21 et 43 ans. Toutes étaient musulmanes mariées, mariage légitimé par la Charia, dont trois mariages consanguins, sauf une originaire de la République Démocratique du Congo qui était chrétienne et concubine. La majorité des femmes étaient fonctionnaires et avaient un niveau de scolarisation moyen à élevé. Toutes les patientes ont bénéficié d'une consultation de génétique médicale au cours de laquelle il leur a été donné des informations sur la technique, son intérêt et ses limites. Il s'agit de femmes enceintes qui avaient soit un âge maternel élevé ou des signes d'appel échographiques et/ ou biochimiques. Une des patientes était porteuse d'une translocation robertsonienne t(14;21) équilibrée. Une amniocentèse a été réalisée chez toutes les gestantes et aucun avortement n'a était induit par ce geste invasif. L’âge gestationnel moyen à la première consultation était de 14 semaines d'aménorrhée (SA) et à l'amniocentèse était de 16 SA et 5 jours. L'analyse FISH a été réalisée, après consentement des couples, sur des cellules non cultivées à partir des échantillons de liquides amniotiques, en utilisant des sondes spécifiques du chromosome 21. Résultats Parmi les 23 patientes qui ont bénéficiées d'un diagnostic anténatal de la trisomie 21 par la technique FISH, nous avons pu rassurer 21 d'entre elles, et nous avons détecté deux cas de trisomie 21 fœtal. Conclusion La technique FISH permet un diagnostic anténatal rapide, en moins de 48h, de la trisomie 21 sur

  19. Research on engineering geological properties and transformation measurements of salted frozen soil of the Ali airport%阿里机场盐渍化冻土工程地质特性及其改良

    Institute of Scientific and Technical Information of China (English)

    孙俊; 张旭

    2013-01-01

    Ali airport is located in the Ali region of Tibet, which is the second highest airport above sea level in China. It lies in a unique climate zone in the cold plateau with monsoon and drought. The annual average temperature in most of the time of the year is below zero degree centigrade. Groundwater in the shallow aquifer contains salt, forming the salted frozen soil foundation at the airport. The engineering geological properties of the salted frozen soil are unique. There is not any experience in design and construction of airport of this kind in the history of Chinese airport construction. By examining the engineering geological properties, this paper puts forward a series of targeted treatment schemes applied to engineering construction. The airport is now safely operated and monitored by related tests for more than two years. It is proven that these technical schemes have successfully shoveled the problem of seasonal salted frozen soil in the airport runway foundation. The results also provide experience for similar airport construction in the plateau area of China.%阿里机场位于西藏阿里地区,是我国海拔第二高机场,处于高原寒带季风干旱气候区,年平均气温在0℃以下.由于机场场区地下水埋深浅,且含有一定盐分,形成了盐渍化季节性冻土.盐渍化季节性冻土工程地质性质独特,在我国机场建设历史上尚属首次发现,在设计和施工中没有类似工程经验可以借鉴.本文通过对盐渍化季节性冻土工程地质特性的研究,提出了有针对性的技术处理方案,并运用到工程建设中.机场经两年多的运行和相关监测验证,该技术方法成功解决了机场场道地基盐渍化季节性冻土问题,从而为我国类似高原机场建设积累了宝贵经验.

  20. İSMAİL BEY GASPIRALI’NIN ALİ MERDAN TOPÇUBAŞI’NA YAZDIĞI MEKTUPLAR / THE LETTERS WRITTEN BY ISMAIL BEY GASPRINSKIJ TO ALI MERDAN BEY TOPCHUBASHI

    Directory of Open Access Journals (Sweden)

    Rıdvan ÇİTİL

    2015-09-01

    Full Text Available Rusya Müslümanları-Türkleri hakkında bilinmeyenler, araştırmacılar arasında her geçen gün daha çok merak uyandırmaktadır. Bu konuda, yeni belgeler gün yüzüne çıkmakta ve birçok çalışmalar yapılmaktadır. Bu makalemizde 1904-1910 yılları arasında cereyan eden siyasî, kültürel vb. olayları o dönemin en önde gelen aydın, lider ve maarifçilerinden biri olan İsmail Bey Gaspıralı’nın Azerbaycanlı avukat, yazar, gazeteci ve siyaset adamı Ali Merdan Topçubaşı’na yazdığı yedi adet mektuptan takip etme imkânını bulacağız. Böylece o dönemle ilgili en ince ayrıntıları yakalamış ve bazı bilinmeyenleri birinci ağızdan öğrenmiş olacağız. / Unknowns about Russian Muslims-Turks day by day become more and more curious. In this issues, appear new documents and studies are carried out. When it comes to correspondence of Ismail Gasprinski and other intellectuals and the author of the Turkic World the importance of these documents rises one more time. In this study we will have possibility to follow up the political, cultural and so on events that took place between the years 1904-1910, from seven letters whom write one of the leading intellectuals of the authority of that era, one of the leaders and educator Ismail Bey Gasprinski to Azerbaijani lawyer, author, journalist Ali Merdan Topçubashi. So we caught the finest details about that period and will learn unknowns from the first person.

  1. Cross-calibration of the Terra MODIS, Landsat 7 ETM+ and EO-1 ALI sensors using near-simultaneous surface observation over the Railroad Valley Playa, Nevada, test site

    Science.gov (United States)

    Chander, G.; Angal, A.; Choi, T.; Meyer, D.J.; Xiong, X.; Teillet, P.M.

    2007-01-01

    A cross-calibration methodology has been developed using coincident image pairs from the Terra Moderate Resolution Imaging Spectroradiometer (MODIS), the Landsat 7 (L7) Enhanced Thematic Mapper Plus (ETM+) and the Earth Observing EO-1 Advanced Land Imager (ALI) to verify the absolute radiometric calibration accuracy of these sensors with respect to each other. To quantify the effects due to different spectral responses, the Relative Spectral Responses (RSR) of these sensors were studied and compared by developing a set of "figures-of-merit." Seven cloud-free scenes collected over the Railroad Valley Playa, Nevada (RVPN), test site were used to conduct the cross-calibration study. This cross-calibration approach was based on image statistics from near-simultaneous observations made by different satellite sensors. Homogeneous regions of interest (ROI) were selected in the image pairs, and the mean target statistics were converted to absolute units of at-sensor reflectance. Using these reflectances, a set of cross-calibration equations were developed giving a relative gain and bias between the sensor pair.

  2. Hydrogen Storage Properties of La1-xYxNi5-yAly Alloys%La1-xYxNi5-yAly合金的储氢性能研究

    Institute of Scientific and Technical Information of China (English)

    罗刚; 胡晓晨; 李慎兰; 陈伟; 韩兴博; 陈江平; 陈德敏; 杨柯

    2012-01-01

    从晶体结构、吸放氢性能和抗粉化性能的角度研究了La1-xYxNi5-yAly (x=0.6,0.7;y=0.1,0.2)金属氢化物合金用于高气压氢压缩机的可行性.XRD分析表明,合金都为CaCu5型六方结构,晶胞体积随着Y含量的增加而减小,随着Al含量的增加而变大.采用恒温体积法在20、30和40℃的实验条件下,对合金的吸放氢PCT曲线和吸氢动力学曲线进行了测定.结果表明,Y和Al能够有效地调节合金的吸放氢平台压,其中Y使合金的平台压升高,Al使合金的平台压降低,两种元素对LaNis基合金的其它储氢性能没有明显的负面影响.分析表明,这些合金能够以“合金对”的形式应用于双级金属氢化物压缩机中,将室温下的2 MPa的低压氢增压为35~40 MPa的高压氢,放氢温度为135~155℃.%The feasibilities of La1-xYxNi5-yAly alloys (x=0.6,0.7; y=0.1,0.2) applied in metal hydride high-pressure compressor were investigated systematically in terms of the crystal structure,hydrogen absorption/desorption properties and pulverization resistance.XRD analyses show that all the investigated alloys present CaCus type hexagonal structure and the unit cell volume decreases with the increase of Y,but increases with the increase of Al content.The pressure-composition isotherms and absorption kinetics were measured at 20,30 and 40 ℃ by the volumetric method.Hydrogen absorption/desorption measurement reveals that Y and Al could effectively increase and decrease the equilibrium hydrogen pressure,respectively.They are ideal elements to adjust the equilibrium hydrogen pressure of LaNi5-based alloys without other remarkable negative influences.We think that the alloys could be matched as ‘alloy pairs' and applied in a double-stage metal hydride compressor;the compressor could boost the feed hydrogen gas at room temperature from 2 MPa to 35~40 MPa at 135~155 ℃.

  3. al-Ghabbân Ali Ibrâhîm, Les deux routes syrienne et égyptienne de pèlerinage au nord-ouest de l’Arabie Saoudite, Le Caire, Institut français d’archéologie orientale, Textes arabes et études islamiques 44/1, 2011, 759 p., 290 fig.

    OpenAIRE

    Frédéric Imbert

    2012-01-01

    La toute récente publication des travaux du chercheur saoudien Ali Ibrâhîm al-Ghabbân, dans les collections de l’IFAO, est un événement scientifique qu’il convient de marquer d’une pierre blanche. Voilà enfin mis à la disposition du public un ouvrage en français traitant d’archéologie et d’épigraphie islamiques sur les terres du Royaume d’Arabie Saoudite. Il serait inexact de dire que les ouvrages saoudiens sur l’archéologie d’époque islamique font défaut ; bien au contraire, le royaume conna...

  4. al-Ghabbân Ali Ibrâhîm, Les deux routes syrienne et égyptienne de pèlerinage au nord-ouest de l’Arabie Saoudite, Le Caire, Institut français d’archéologie orie

    OpenAIRE

    Imbert, Frédéric

    2013-01-01

    La toute récente publication des travaux du chercheur saoudien Ali Ibrâhîm al-Ghabbân, dans les collections de l’IFAO, est un événement scientifique qu’il convient de marquer d’une pierre blanche. Voilà enfin mis à la disposition du public un ouvrage en français traitant d’archéologie et d’épigraphie islamiques sur les terres du Royaume d’Arabie Saoudite. Il serait inexact de dire que les ouvrages saoudiens sur l’archéologie d’époque islamique font défaut ; bien au contraire, le royaume conna...

  5. 中小微企业网络融资模式实验--以“阿里小贷”为例%The Small and Medium-sized Enterprise Network Financing Model Experiment---Taking “Ali Micro Credit” as an Example

    Institute of Scientific and Technical Information of China (English)

    吴俊英

    2014-01-01

    “网络融资”是解决中小微企业融资难问题的新型融资模式。以阿里巴巴小额贷款股份有限公司(简称阿里小贷)小额网络信贷的金融实验为典型案例,从运营特征、贷款技术、风险控制、信用体系方面展开分析,得出结论:网络贷款快速、高效的特性切合了中小微企业融资“短、频、快”实际需求,网络贷款的灵活性降低了中小微企业融资成本,网络信用数据库的建立提高了企业信息透明度,信息的无障碍传播降低了中小微企业授信成本。%“Network financing” is a new financing mode to solve the financing problem of micro , small and me-dium-sized enterprises .This paper takes Alibaba Micro Credit Limited ’ s ( referred to Ali ) network loan experi-ments as the typical case, has an analysis on operational features , loan techniques, risk control, credit system and concludes:Network loans ’ fast and efficient features can meet the financing demands of micro , small and medium-sized enterprises -“short, frequent, fast”.The flexibility of network loans reduces loan financing costs of mi-cro, small and medium-sized enterprises.The establishment of network credit database improves the enterprise in-formation transparency , and barrier-free information communication reduces the enterprise credit cost .

  6. INVENTORY OF THE INVASIVE ALIE N PLANT SPECIES IN INDONESIA

    Directory of Open Access Journals (Sweden)

    SRI S UDARMIYATI T JITROSOEDIRDJO

    2005-01-01

    Full Text Available An inventory of the alien plant species in Indone sia based on the existing references and herbarium specimens concluded that 1936 alien plant species ar e found in Indonesia which belong to 187 families. Field studies should be done to get the complete figur es of alien plant species in Indonesia. Based on the existing figures of the plant species, the invasive alien plant species can be iden tified, followed by studies on the assessment of losses, biology, management and their possible utilizations. Alien plant species are imported to Indonesia for cultivation, collection of the botanical garden, as experimental plants or other curiosities. Aside from plants purposely imported, there are also introduced plant propagules conta-minating imported agricultural products. These alien plant species can be beneficial or have a potential of being invasive. The alien cultivated species consisted of 67% of the total number. More than half of the cultivated plants are ornamental plants. Some of th e species are naturalized or escaped from cultivation and become wild and invasive. Some other natura lized species, adapted well without any problems of invasion. There are 339 species or 17% of the species r ecorded as weeds. The highest record of weeds is found in the family of Poaceae (57 species, follo wed by Asteraceae (53 species and Cyperaceae (35 species. There are 6 families having more than 10 species of weeds: Amaranthaceae, Asteraceae, Cyperaceae, Euphorbiaceae, Poaceae, and Rubiaceae. Three families have more than 100 species: Asteraceae 162 species, Poaceae 120 species, and Papillionaceae 103 species. Five species of aquatic and 20 species of terrestrial plants considered as important alien plant species in Indonesia were identified and some of their distributions noted

  7. Premagovanje panične motnje z ali brez agorafobije

    OpenAIRE

    Šeško, Anja

    2012-01-01

    Panični napad je duševna motnja, ki lahko prizadene vsakega izmed nas. Napade pogosto spremljajo telesni občutki, kot so dušenje, potenje, omotičnost, pospešeno bitje srca, tresenje itd. Velikokrat pa imajo posamezniki tudi strah pred smrtjo. Panični napadi po navadi trajajo le kakšno minuto, vendar pa so za osebo, ki jih doživlja, izjemno neprijetni. Veliko ljudi, ki trpijo zaradi napadov panike, razvije agorafobijo, motnjo, ki posamezniku pogosto preprečuje, da bi zapustila dom. V stra...

  8. Challenge and Opportunity: the ALI/III Global Principles Project

    Directory of Open Access Journals (Sweden)

    IF Fletcher

    2008-04-01

    Full Text Available This article deals with an international project to establish the extent to which it is feasible to achieve a worldwide acceptance of the Principles of Cooperation among the NAFTA Countries together with the Guidelines Applicable to Court-to-Court Communications in Cross-Border Cases. This contribution explains the process whereby the American Law Institute and the International Insolvency Institute (1 developed principles of cooperation with regard to cross-border insolvency; (2 established acceptance of these principles in jurisdictions across the world, subject to any necessary local modifications; and (3 obtained the endorsement of leading domestic associations, courts, and other groups in those jurisdictions. This article may contribute to the development the South African cross-border insolvency law. The inclusion of the challenges of harmonisation of private international law is also contributing to current debate.

  9. PLAVA RIBA – PREDNOSTI ALI I NEKI RIZICI KONZUMIRANJA

    OpenAIRE

    Nosić, Mario; Krešić, Greta

    2015-01-01

    Plava riba je nutritivno izrazito vrijedna, lako probavljiva namirnica koja je izvor biološki vrijednih bjelančevina, joda i selena dok istovremeno sadrži malo masti i ima niski sadržaj kolesterola. Vrijedan je izvor višestruko nezasićenih masnih kiselina kojima se pripisuju brojni pozitivni učinci na zdravlje. Međutim uz konzumaciju plavu ribu mogu biti vezani i određeni rizici, primjerice, histaminsko trovanje. Histaminsko trovanje morskom ribom uzrokuje 5% svih oboljenja vezanih za hranu k...

  10. Earth Observing 1 Advanced Land Imager (ALI): 2009-2010

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Global Land Survey (GLS) datasets are a collection of orthorectified, cloud-minimized Landsat-type satellite images, providing near complete coverage of the...

  11. Earth Observing-1 Advanced Land Imager (ALI): 2004-2008

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Global Land Survey (GLS) datasets are a collection of orthorectified, cloud-minimized Landsat-type satellite images, providing near complete coverage of the...

  12. Efektifitas Pemijatan Perineum Terhadap Ruptur Perineum di Klinik Bersalin Fatimah Ali I dan Fatimah Ali II Marendal Medan Tahun 2010

    OpenAIRE

    Royyany, Tengku

    2010-01-01

    Perkembangan ilmu kesehatan masyarakat telah mengantar kita pada paradigma baru, sehingga kini paradigma sehat menjadI orientasi baru pembangunan kesehatan dunia, termasuk Indonesia yang dirumuskan dalam suatu visi “Indonesia Sehat 2010”. Hal yang mendasar pada paradigma sehat antara lain terjadinya: pergeseran dari pelayanan medis (medicalcare) sehingga setiap upaya penanggulangan masalah kesehatan lebih menonjolkan aspek peningkatan (promotive) dan cpencegahan (preventive) dibanding pengoba...

  13. Management in ekonomija: ali je to dvoje ali eno? (Elementi in razumevanje postocializma in managerske revolucije = Management and Economy: Are They the Same Or Not?

    Directory of Open Access Journals (Sweden)

    Tonci Kuzmanic

    2007-03-01

    Full Text Available Author starts from important but suppressed equalisation of economy and management in post socialist and post capitalist circumstances which represents the very essence of post-modern global dominance (globalisation. An attempt to distinguish economy from management is connected with the appearance of neo-liberalism as the central argumentative machinery of management being connected with postmodern type of subjectivity. In comparison with the so-called »objective law« around which economy used to revolve (ideally, of course, management explicitly leaves this terrain and opens itself up to the subjective, even subversive activity at the level of global society. In that sense economy and management are operating on two radically different levels and we could even speak of two different entities which should be analytically distinguished. The very supposition for modern defence with regard to post-modern forms of dominance is exactly a possibility of differentiating between economy and management.

  14. ALI/ARDS抗炎治疗研究的策略与展望%Present strategies and future perspectives for therapies of ALI/ARDS

    Institute of Scientific and Technical Information of China (English)

    李玉梅; 卫洪昌

    2009-01-01

    急性肺损伤(acute lung injury,ALI)既是呼吸道重大疫病(如SARS、禽流感)的病理基础,也是全身炎症反应综合征(systemic inflammatory response syndrome,sins)时最易出现的组织损伤。ALI进一步发展即为急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)。随着失控性的炎症反应(uncontrolled inflammatory response)引发多器官功能障碍综合征(muhipile organs disfunction syndrome,MODS)学说的提出,人们对ALI/ARDS认识转向对炎症发生、调控的认识,参与炎症反应的炎症细胞和细胞因子则成为研究的热点3。

  15. Laser surface cladding of ZM5 Mg-base alloy with Al+Y powder

    Institute of Scientific and Technical Information of China (English)

    陈长军; 王东生; 王茂才

    2004-01-01

    The surface properties of ZM5 Mg-base alloy were modified by laser cladding with Al+ Y powder. Laser cladding was carried out with a 5 kW continuous wave CO2 laser by melting the preplaced powder mixture of Al and Y. Following laser cladding, the cladding zone was characterized by a detailed microstructural observation and phase analysis. Moreover, the microhardness and element distribution were evaluated in detail. The surface modified layer consists of Mg17 Al12 and Al4 MgY phases, while a-Mg and Mg17 Al12 in the substrate. The microhardness of the cladding zone was significantly enhanced as high as HV122 - 180 as compared to HV60 - 80 of the substrate region. The maximal hardness about HV224 is in the interface due to the formation of intermetallic Mg17 Al12 phase. The microstructure is refined and Mg diffuses into the cladding material which leads to the formation of Mg17 Al12.

  16. Trženjski splet v ekonomski teoriji ali "chamberlinovih" 4p

    OpenAIRE

    Lah, Marko

    2014-01-01

    Prispevek obravnava korenine trženjske teorije 4P oziroma njenih posameznih elementov v delu ekonomista Edwarda H. Chamberlina. Trženjsko videnje Chamberlinove teorije monopolistične konkurence, kar je jedrnato prikazano s "Chamberlinovo" tabelo 4P - pokaže, da je Chamberlina mogoče videti kot začetnika teorije 4P. Takšen pristop izpostavlja pomen Chamberlinove kratkoročne analize oziroma - v trženjskem jeziku - ohranjanja kratkoročnih konkurenčnih prednosti podjetja, ki nastajajo zaradi učin...

  17. Oxidation resistant and low coefficient of thermal expansion Nia1-CoCrAly alloy

    Science.gov (United States)

    Hebsur, Mohan G. (Inventor)

    2004-01-01

    A bond coat composition for use in thermal barrier coatings comprises a NiAl--CoCrAlY matrix containing particles of AlN dispersed therein. The bond coat composition is prepared by croymilling NiAl and CoCrAlY in liquid nitrogen.

  18. Recommended ALIs and DACs for 10 CFR part 220: A consistent numerical set

    Energy Technology Data Exchange (ETDEWEB)

    Eckerman, K.F.

    1996-05-01

    Appendix B to 10 CFR Part 20 contains numerical data for controlling the intake of radionuclides in the workplace or in the environment. These data, derived from the recommendations of the International Commission on Radiological Protection (ICRP), do not provide a numerically consistent basis for demonstrating compliance with the limitation on dose stated in the regulation. This situation is largely a consequence of the numerical procedures used by the ICRP which did not maintain, in a strict numerical sense, the hierarchial relationship among the radiation protection quantities. In this work recommended values of the quantities in Appendix B to CFR Part 20 are developed using the dose coefficients of the applicable ICRP publications and a numerical procedure which ensures that the tabulated quantities are numerically consistent.

  19. Pivško jygajo se 'guncajo se' (Petelinje) ali o nastanku slovenskega razmerja jugati : gugati:

    OpenAIRE

    Furlan, Metka

    2010-01-01

    Since the Pivka dialect does not have second palatalization of velars, the verb jyugajo se 'they are swinging' (Petelinje), with its Slovene phonetic equivalents from Slovene gúgati se, is explained with dissimilation g : g --> o : g and the appearance of the prothetic -j.

  20. Development of Resource Sharing System Components for AliEn Grid Infrastructure

    CERN Document Server

    Harutyunyan, Artem

    2010-01-01

    The problem of the resource provision, sharing, accounting and use represents a principal issue in the contemporary scientific cyberinfrastructures. For example, collaborations in physics, astrophysics, Earth science, biology and medicine need to store huge amounts of data (of the order of several petabytes) as well as to conduct highly intensive computations. The appropriate computing and storage capacities cannot be ensured by one (even very large) research center. The modern approach to the solution of this problem suggests exploitation of computational and data storage facilities of the centers participating in collaborations. The most advanced implementation of this approach is based on Grid technologies, which enable effective work of the members of collaborations regardless of their geographical location. Currently there are several tens of Grid infrastructures deployed all over the world. The Grid infrastructures of CERN Large Hadron Collider experiments - ALICE, ATLAS, CMS, and LHCb which are exploi...

  1. Šalies neįgaliųjų sporto plėtros modeliavimas

    OpenAIRE

    Rimšaitė , Simona

    2008-01-01

    Darbo tikslas - išanalizuoti neįgaliųjų sporto būklę Lietuvoje ir tendencijas pasaulyje bei sukurti neįgaliųjų sporto plėtros modelį, kuris sudarytų sąlygas vystytis neįgaliųjų sportui Lietuvoje. Neįgaliųjų sportas yra žaidžiamas asmenų su negalia, įskaitant fizinę ir protinę negalią. Neįgaliųjų sporto plėtojimo procesas yra ilgas procesas, reikalaujantis daug pastangų. Mūsų šalyje trūksta sporto klubų, kurie būtų pritaikyti neįgaliems asmenims, taip pat kvalifikuotų trenerių, bet ir finansav...

  2. L’aliénation, le conséquentialisme et les exigences de la morale

    Directory of Open Access Journals (Sweden)

    Peter Railton

    2008-02-01

    Full Text Available Parution originale sous le titre « Alienation, Consequentialism and the Demands of Morality » dans _Philosophy and Social Affairs_, vol. 13, No. 2 (Printemps 1984, pp. 134-171. Traduit de l’Anglais par Eric Guindon, révisé par Christine Tappolet.

  3. "Ženske v integriranem vezju" ali na poti posodobljenih raziskovanj spola:

    OpenAIRE

    Vendramin, Valerija

    2011-01-01

    By proceeding from a specific epistemological perspective, the author sheds some light on the conditions of learning and delves into the issue of "better" (or perhaps more adequate) gender research in education and beyond. She highlights the position of feminist epistemology that the knowing subject is always "somewhere", in a certain social "location" that enables his or her view and constrains it at the same time. She problematizes the traditional view of research, which understands it as a...

  4. Feministična krivda ali ambivalentnost feminizma do lepotnih praks

    OpenAIRE

    Otorepec, Klara

    2015-01-01

    Namen diplomskega dela je raziskati različne dejavnike, ki sooblikujejo in tvorijo koncept feministične krivde. Tako poimenujem občutek nelagodja, ki nastopi kot odziv na težave pri uveljavljanju feminističnih načel v vsakodnevnem življenju v odnosu do (ne)prakticiranja lepotnih praks oziroma kot razpetost med feministično ideologijo in patriarhalno družbeno ureditvijo. V teoretičnem delu raziskujem, kako pritisk k normativni ženskosti kot focaultovski disciplinirajoči projekt sodobne družbe,...

  5. Studying the potential role of ALIS proteins on the functionality of ALA2

    DEFF Research Database (Denmark)

    Lopez Marques, Rosa Laura; Poulsen, Lisbeth Rosager; Meffert, Katharina;

    The plant P4-ATPase ALA2 is involved in flipping of phosphatidylserine analogues Rosa Laura López-Marqués1, Lisbeth Rosager Poulsen1, Katharina Meffert2, Thomas Pomorski2, Michael Gjedde Palmgren1 1Centre for Membrane Pumps in Cells and Disease - PUMPKIN, Danish National Research Foundation...

  6. Approximating tasseled cap values to evaluate brightness, greenness, and wetness for the Advanced Land Imager (ALI)

    Science.gov (United States)

    Yamamoto, Kristina H.; Finn, Michael P.

    2012-01-01

    The Tasseled Cap transformation is a method of image band conversion to enhance spectral information. It primarily is used to detect vegetation using the derived brightness, greenness, and wetness bands. An approximation of Tasseled Cap values for the Advanced Land Imager was investigated and compared to the Landsat Thematic Mapper Tasseled Cap values. Despite sharing similar spectral, temporal, and spatial resolution, the two systems are not interchangeable with regard to Tasseled Cap matrices.

  7. Izbira najprimernejšega hladiva enostopenjske ali dvostopenjske visokotemperaturne toplotne črpalke

    OpenAIRE

    Ceglar, Simon

    2016-01-01

    Energetske in ekološke krize ter omejenost zalog fosilnih goriv so pripeljale do svetovnega trenda iskanja obnovljivih virov energije, pri čemer je geotermalna energija ena najpomembnejših. Hkrati pa nas k temu zavezujejo tudi evropske direktive, ki smo jih sprejeli v obliki novega Energetskega zakona (EZ-1), z namenom zagotavljanja zanesljive oskrbe z energijo in energetskimi storitvami ob upoštevanju trajnostnega razvoja. Namen diplomske naloge je preučiti možnost uporabe visokotemperat...

  8. Slovenske slikanice: rušenje stereotipov ali nadaljevanje patriarhalnih vzorcev

    OpenAIRE

    Žnidarčič, Mateja

    2016-01-01

    V diplomskem delu analiziram stereotipne upodobitve likov v slikanicah izdanih med letoma 2011 in 2014, hkrati pa izpostavljam tudi odmike od takega upodabljanja likov. Raziskujem jih s pristopi s področja feministične literarne vede. Spremembe v družbi odsevajo tudi v literaturi, zato jim sledim v slikanicah. Predstavim rezultate raziskav Adele Turin, Igorja Sakside, Katje Koren Valenčič, ki so se v devetdesetih letih 20. stoletja ukvarjali z analiziranjem stereotipnih podob spolnih vlog in ...

  9. VARIETY OF GRAY-SCALE SONOGRAPHIC APPEARANCE OF UNTREATED LIVER METASTASES ALI HADIDI

    Directory of Open Access Journals (Sweden)

    ALI HADIDI

    1982-07-01

    Full Text Available Encountered wit h b izarre patterns o f l i v e r metas t a s es dec l i ned our accuracy rate s o the humi liation o f mist ake s motivated me to re-assess t he value o f hepatic sonography in patients s u spe c t ed o f having metastatic l i ver neoplasms . 43 pat ients , who had no t recieved any prior the r a phy , had been studied by gray-scale ult r a s ound . The echographic evidence i n accordance with o ur e x p e r ~ e n ce can be categorized as fo l l ows : I l a rge echo g enic or ~c ho poor area , II d iscrete masse s wi t.h high-level e c hoes spreaded t hroughout a lobe o f the l i ve r , III e cho f ree mass with i r regular mar q i.n , r .J d i f f use a lterat ion of the homogeneous e cho pattern of t he liver , V Bull ' s - eye ,VI abscess like,VII sol id echogenic mass vei th a centra l hyperechoic hor izontal l i ne , VIII echogenic mass ".;i t;l two l a t eral hypo e choic marg i n s, rX isodense e chog eni c a r ea bounded by an hypoechoic c i r c l e . The f e at u r e s seen i n l iver ultra sonography of t he entire pat t e r ns , a nd those s e en as new c r i teria are presented ~

  10. ALiCCE: Atomic Lines Calibration using the Cross-Entropy Algorithm

    CERN Document Server

    Martins, Lucimara; Caproni, Anderson; Vitoriano, Roberto

    2014-01-01

    Atomic line opacities play a crucial role in stellar astrophysics. They strongly modify the radiative transfer in stars, therefore impacting their physical structure. Ultimately, most of our knowledge of stellar population systems (stars, clusters, galaxies, etc.) relies on the accuracy with which we understand and reproduce the stellar spectra. With such a wide impact on Astronomy, it would be ideal to have access to a complete, accurate and precise list of atomic transitions. This, unfortunately, is not the case. Few atomic transitions had their parameters actually measured in the laboratory, and for most of the lines the parameters were calculated with low precision atomic energy levels. Only a small fraction of the lines were calibrated empirically. For the purpose of computing a stellar spectral grid with a complete coverage of spectral types and luminosity classes, this situation is rather limiting. We have implemented an innovative method to perform a robust calibration of atomic line lists used by spe...

  11. Is surfactant a promising additive drug in ALI/ARDS-patients?

    NARCIS (Netherlands)

    Schultz, MJ; Kesecioglu, J

    2004-01-01

    The rationale for surfactant replacement therapy in patients with acute respiratory distress syndrome (ARDS) is to restore the normal composition of the surfactant system, as well as to overcome ongoing inactivation of present surfactant. Indeed, surfactant replacement therapy call normalize the com

  12. The Al(I) molecule, Ph2COAl and its anion

    Science.gov (United States)

    Zhang, Xinxing; Eichhorn, Bryan; Schnöckel, Hansgeorg; Bowen, Kit

    2016-08-01

    We have formed the Al(I)-containing molecule, benzophenone-aluminum, i.e., Ph2COAl, and studied it by conducting density functional theory calculations on both its neutral and anionic forms and by measuring the photoelectron spectrum of its anion. Our calculations identified two nearly iso-energetic anion isomers, (Ph2COAl)-, the vertical detachment energies (VDE) of which are in excellent agreement with our photoelectron spectrum. Natural population analysis (NPA) of Ph2COAl found the Al moiety to be positively charged by +0.81 e, indicating a strongly ionic bond between Al and Ph2CO, i.e., Ph2CO-Al+.

  13. 76 FR 11756 - Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges

    Science.gov (United States)

    2011-03-03

    ... Act of 1950 (50 U.S.C. 783(b)), or section 38 of the Arms Export Control Act (22 U.S.C. 2778).'' 15..., 2010 (75 FR 50,681, August 16, 2010), has continued the Regulations in effect under the International..., selling, delivering, storing, disposing of, forwarding, transporting, financing, or otherwise servicing...

  14. Magnetic ordering in PrBa2Cu3-yAlyO6+x

    DEFF Research Database (Denmark)

    Longmore, A.; Boothroyd, A.T.; Chen, C.K.;

    1996-01-01

    The magnetic ordering in single crystals of PrBa2CU3O6+x has been investigated by elastic neutron scattering over the full range of temperatures for reduced and oxygenated crystals. The crystals were grown in alumina crucibles and therefore contained dissolved aluminum on the Cu(1) site. Both...... aluminum and oxygen contents were analyzed in detail in order to establish their effects on the magnetic ordering, Our crystals exhibited Pr ordering and the two types of antiferromagnetic Cu ordering frequently reported in related compounds, but our results differ in several respects from previous studies...... axis, we find the moment to be aligned well away from the c axis, in agreement with recent Yb-170(3+) Mossbauer spectroscopy results. Ridges of scattering indicative of 2D magnetic ordering were seen in both oxygenated and reduced crystals, though we believe different magnetic moments are responsible...

  15. Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS)

    DEFF Research Database (Denmark)

    Holmqvist, Anna Sällfors; Olsen, Jørgen H.; Mellemkjaer, Lene;

    2015-01-01

    all autoimmune diseases combined, corresponding to an AER of 67 per 100 000 person-years. The SHRRs were significantly increased for autoimmune haemolytic anaemia (16.3), Addison's disease (13.9), polyarteritis nodosa (5.8), chronic rheumatic heart disease (4.5), localised scleroderma (3......OBJECTIVES: The pattern of autoimmune diseases in childhood cancer survivors has not been investigated previously. We estimated the risk for an autoimmune disease after childhood cancer in a large, population-based setting with outcome measures from comprehensive, nationwide health registries.......6), idiopathic thrombocytopenic purpura (3.4), Hashimoto's thyroiditis (3.1), pernicious anaemia (2.7), sarcoidosis (2.2), Sjögren's syndrome (2.0) and insulin-dependent diabetes mellitus (1.6). The SHRRs for any autoimmune disease were significantly increased after leukaemia (SHRR 1.6), Hodgkin's lymphoma (1...

  16. World music, authenticity and Africa: Reading Cesaria Evora and Ali Farka Toure

    OpenAIRE

    Anandam Kavoori

    2011-01-01

    In this essay, I engage with the complex set of sonic connections known as 'World Music'. The section on 'Framing World Music/The Global Postmodern/Authenticity' outlines some key elements in how World Music can be theoretically framed - as a specific kind of text, anchored in conditions of global post modernity and characterized by a defining discourse - that of 'authenticity'. This is followed by a biographical/textual account of two major global music stars from Africa - Cesaria Evora (Cap...

  17. Direct evidence of the fermi-energy-dependent formation of Mn interstitials in modulation doped Ga1-yAlyAs/Ga1-xMnxAs/Ga1-yAlyAs heterostructures

    Energy Technology Data Exchange (ETDEWEB)

    Yu, K.M.; Walukiewicz, W.; Wojtowicz, T.; Lim, W.L.; Liu, X.; Dobrowolska, M.; Furdyna, J.K.

    2004-01-30

    Using ion channeling techniques, we investigate the lattice locations of Mn in Ga{sub 1-x}Mn{sub x}As quantum wells between Be-doped Ga{sub 1-y}Al{sub y}As barriers. The earlier results showed that the Curie temperature T{sub C} depends on the growth sequence of the epitaxial layers. A lower T{sub C} was found in heterostructures in which the Ga{sub 1-x}Mn{sub x}As layer is grown after the modulation-doped barrier. Here we provide direct evidence that this reduction in T{sub C} is directly correlated with an increased formation of magnetically inactive Mn interstitials. The formation of interstitials is induced by a shift of the Fermi energy as a result of the transfer of holes from the barrier to the quantum well during the growth.

  18. Egypt's Pop-Music Clashes and the “World-Crossing” Destinies of Muhammad Ali Street Musicians

    OpenAIRE

    Puig, Nicolas

    2006-01-01

    The “suq al-Musiqiyyin”, the musicians' market, in Cairo refers to the social space of non academic music and especially of music played at weddings. This is a vernacular notion that covers everything at the same time, musical training, social affiliations and professional practice of non-academic music. This practice is linked most of the time to family events and especially wedding celebrations – but there is also private evenings and celebrations of mûlid (saint's festival). So we can call...

  19. Internetinės žiniasklaidos verslo organizavimo aspektai: mažos šalies patirtis

    OpenAIRE

    Mažeikienė, Giedrė

    2008-01-01

    Internetinė žiniasklaida, kaip savarankiška verslo ir žiniasklaidos sritis, gyvuoja jau daugiau nei dešimtmetį Lietuvoje. Perėjusi įvairias vystymosi stadijas, šiuo metu ji yra viena iš pelningiausių verslo sričių bei svarbi reklamos rinkos dalis. Tą įrodo ir egzistuojantys teiginiai „jei tavęs nėra internete, tavęs nėra niekur“, ir gausiai besikuriančios viešųjų ryšių agentūros, besistengiančios bendradarbiauti su internetine žiniasklaida, ir vis augantis internetinės žiniasklaidos vartotoji...

  20. Reading Studies Of A Story Named “Şarap Lekesi” By Hasan Ali Toptaş

    Directory of Open Access Journals (Sweden)

    Mustafa ÇALDAK

    2009-06-01

    Full Text Available Şarap Lekesi, which includes meaning blanks, reticence and numerous dark points, is a story which melts the real truth and fiction world into each other, creating a new world, and in which the author leaves his dominant position to readers. The story embraces as many meanings as its number of readers. There is no single focused idea/meaning in the text. The plot of the story is based on a wine spot on a table, and imaginary characters are created, and the dog, Alyoşa, is used as a metaphor for reticence/ silence. This short and deep story is analyzed in three aspects: the sole existence of the text as an object; Alyoşa as the language of reticence/silence and self-deconstruction.

  1. VizieR Online Data Catalog: PCF, SpecB or SDSSB asteroids parameters (Ali-Lagoa+, 2016)

    Science.gov (United States)

    Ali-Lagoa, V.; Licandro, J.; Gil-Hutton, R.; Canada-Assandri, M.; Delbo, M.; de, Leon J.; Campins, H.; Pinilla-Alonso, N.; Kelley, M. S. P.; Hanus, J.

    2016-04-01

    The table contains the best-fitting values of size and beaming parameter and corresponding visible geometric albedos for all our objects. We fitted the near-Earth asteroid thermal model of Harris (1998Icar..131..291H) to WISE/NEOWISE thermal infrared data (see, e.g., Mainzer et al., 2011ApJ...736..100M and Masiero et al., 2014ApJ...791..121M). Minimum relative errors of 10, 15, and 20 percent should be considered for size, beaming parameter and albedo in those cases for which the beaming parameter could be fitted. Otherwise, a default value of the beaming parameter is assumed (its negative value is given in the table) and the minimum relative errors in size and albedo increase to 20 and 40 percent (see, e.g., Mainzer et al., 2011ApJ...736..100M). We also provide the asteroid absolute magnitudes and slope parameters retrieved from the Minor Planet Center (MPC), the number of observations used in each WISE band (W3 and W4), plus the corresponding average values of heliocentric and geocentric distances and phase angle (r, g, a) based on the ephemerides taken from the MIRIADE service (http://vo.imcce.fr/webservices/miriade/?ephemph). The subsample label indicates whether the object belongs to the SDSS, spectroscopic B or PCF groups. Labels with the suffix 'qA' indicate that only data with signal-to- noise ratio greater than 10 were used for that case (see Appendix A of the article for more details). (1 data file).

  2. Analiza ekonomske upravičenosti izločanja plastike za energetsko ali snovno izrabo odpadkov

    OpenAIRE

    Golavšek, Matej

    2013-01-01

    V skladu z direktivami EU je ravnanje z odpadki urejeno v obliki hierarhije, kjer si od najvišje do najnižje prioritete sledijo preprečevanje, ponovna uporaba, snovna izraba, energetska izraba in odlaganje odpadkov na deponijah. V magistrskem delu smo analizirali ekonomske in okoljske faktorje procesov snovne in energetske izrabe odpadkov, ki jih uporabljamo, kadar se nastanku odpadkov ne moremo izogniti. Dodali smo tudi tehnično-ekonomsko analizo avtomatskega in ročnega izločanje plastike iz...

  3. Optimization and Calculation of TbCl3-ACl (A=Li, Na, K, Rb, Cs) Phase Diagrams

    Institute of Scientific and Technical Information of China (English)

    Sun Yimin; Zhang Jing; Guan Mingyun; Qiao Zhiyu

    2005-01-01

    By using CALPHAD (Calculation of Phase Diagram) technique the optimization and calculation of the binary systems of TbCl3-ACl (A= Li, Na, K, Rb, Cs) were carried out. For describing the Gibbs free energy of liquid phase in these systems the new modified quasichemical model in the pair-approximation for short-range ordering was used. From measured phase equilibria data and experimental integral properties the TbCl3-ACl phase diagrams were optimized and calculated. A set of thermodynamic functions was optimized based on an interactive computer-assisted analysis. The calculated phase diagrams and thermodynamic data are self-consistent.

  4. The Prevalence of fungal infections in children with hematologic malignancy in Ali-Asghar Children Hospital between 2005 and 2010

    OpenAIRE

    Ansari, Sh.; Shirzadi, E; Elahi, M.

    2015-01-01

    Background A fungal infection represents a growing problem in children with hematologic malignancies, during chemotherapy induced neutropenia. Fungal colonization is considered a major risk factor for subsequent fungal infections. The aim of this retrospective study was to evaluate prevalence of fungal infection among children admitted to hospital between 2005 and 2010 in Tehran, Iran. Materials and Methods 617 hematological patients in the age range of neoteric to 19 years old were enrolled ...

  5. Vladimir Nabokov, un exemple d’aliénation créatrice Vladimir Nabokov, an Instance of Creative Alienation

    Directory of Open Access Journals (Sweden)

    Marie Bouchet

    2009-06-01

    Full Text Available The terms “strange” and “stranger” derive from extraneus, a Latin word literally meaning “outside of”. This article proposes to examine the notions of distance and limit which shape the consciousness of a foreigner / outsider—Vladimir Nabokov. Nabokov lost his native land when he was 18, and was condemned to remain a stranger in a foreign land. In his fiction, many “estranged” characters are to be found, especially as main focalizers or first-person narrators. The present article thus demonstrates how the concept of frontier is crucial to interpreting such alien status: these characters are forever estranged, due to geographical borders, temporal distances or linguistic barriers. Nabokov, himself a trilingual writer, challenged the very idea of a foreign language. His English, which he claimed was merely “second rate”, is indeed quite different from the style of American classics, yet it has a unique poetic flavor. Maybe because he “did not think in any language, but in images”, his condition as a foreigner was not felt as alienating. Contrary to most of his characters, hybridization seems to have been a powerful element inspiring his artistic impulse, as illustrated in his extraordinary linguistic virtuosity and his constant playing on words. Similarly, the repeated inclusion of other semiotic codes (painting, photography, advertisements,… shows that by playing with limits and the interpenetration of familiar and strange(r elements, Nabokov found a creative alternative to the usually alienating condition of being a foreigner.

  6. Changes in the structure of MgxAly(OH)z layered double hydroxides during the adsorption of organic compounds

    OpenAIRE

    Butenko, E.O; Kapustina, E.V.; Kapustin, A.E.; Kracvenko, V.S.; GROMILOV S.A.; Guégan, Régis

    2011-01-01

    International audience Layered double hydroxides (LDHs) are used as sorbents, catalysts, and carriers for catalytic species. In general, they are natural or synthetic minerals with part of their cations being replaced isomorphically with cations of higher oxidation states, which results in the formation of positively charged two-dimensional layers containing solvate molecules and counterions capable of anion exchange [1]. LDHs are solid bases [2]. Since there are both Brønsted and Lewis si...

  7. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  8. Slovensko približevanje Evropski uniji: ideološki projekt ali proces (post)modernizacije:

    OpenAIRE

    Hafner-Fink, Mitja

    2000-01-01

    The text starts with the hypothesis that Slovenian's attitudes toward Slovenian accession to EU are strongly influenced by ideological activities of the Slovene political elite and partly by the process of post-modernisation of Slovene society. The hypothesis is tested on the basis of data from the Slovene public opinion survey. It presents the results of a regression analysis which shows the following most important factors of Slovenes' attitudes toward Slovenian accession to EU: level of kn...

  9. Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI)

    Science.gov (United States)

    Karbach, Michael; Braumueller, Sonja; Kellermann, Philipp; Gebhard, Florian; Huber-Lang, Markus; Perl, Mario

    2016-01-01

    Background Severe blunt chest trauma is associated with high mortality. Sepsis represents a serious risk factor for mortality in acute respiratory distress syndrome (ARDS). In septic patients with ARDS complement activation products were found to be elevated in the plasma. In single models like LPS or trauma complement has been studied to some degree, however in clinically highly relevant double hit models such as the one used here little data is available. Here, we hypothesized that absence of C5 is correlated with a decreased inflammatory response in trauma induced septic acute lung injury. Methods 12 hrs after DH in mice the local and systemic cytokines and chemokines were quantified by multiplex bead array or ELISA, activated caspase-3 by western blot. Data were analyzed using one-way ANOVA followed by post-hoc Sidak’s multiple comparison test (significance, p≤ 0.05). Results In lung tissue interleukin (IL)-6, monocyte chemo attractant protein-1 (MCP-1) and granulocyte-colony stimulating factor (G-CSF) was elevated in both C5-/- mice and wildtype littermates (wt), whereas caspase-3 was reduced in lungs after DH in C5-/- mice. Systemically, reduced keratinocyte-derived chemokine (KC) levels were observed after DH in C5-/- compared to wt mice. Locally, lung myeloperoxidase (MPO), protein, IL-6, MCP-1 and G-CSF in brochoalveolar lavage fluid (BALF) were elevated after DH in C5-/- compared to wt. Conclusions In the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent. PMID:27437704

  10. Asmens teisės naujosiose Vidurio ir Rytų Europos šalių Konstitucijose

    OpenAIRE

    Tenčurinaitė, Ina

    2006-01-01

    At the end of XX century, after the collapse of totalitarian regimes, Central and Eastern European states started a new development process related to essential constitutional reforms. It became necessary to ensure human rights and freedoms, their fulfilment and protection. Human rights and freedoms confirmed in the constitutions of Central and Eastern European countries make one of the most fundamental institutions of constitutional law. This master thesis analysis human rights and freedoms ...

  11. Slovenščina in drugi jeziki - vrednota ali grožnja? Programi slovenskih parlamentarnih strank 2008

    OpenAIRE

    Stritar, Mojca

    2015-01-01

    V prispevku so predstavljena stališča slovenskih političnih strank o slovenščini in drugih jezikih v njihovih programih s parlamentarnih volitev 2008. Liberalnejše stranke sledijo evropskim smernicam in zagovarjajo večkulturnost ter podporo manjšinskim jezikom, konservativnejše pa se osredotočajo na slovenščino kot temelj slovenske identitete in predlagajo ukrepe za njeno zaščito.

  12. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... physical symptoms. A key element of her pain management was helping her understand how articulate the ailments ... Aly. Today, Aly is still focused on a quality life. Aly Becker Aly is still the go- ...

  13. PARAÇALI REGRASYON YARDIMIYLA BİTKİ BOYU ZAMAN İLİŞKİSİ PARAMETRELERİNİN TAHMİNİ

    Directory of Open Access Journals (Sweden)

    UFUK KARADAVUT

    2005-01-01

    Full Text Available Bu çalışma Bahri Dağdaş Uluslararası Tarımsal Araştırma Enstitüsü Deneme alanlarında yürütülmüştür. Çalışmada Dağdaş-94 buğday çeşiti kullanılmıştır. Bitkilerde lO'ar gün aralıklarla düzenli olarak 15 kez boy ölçümleri yapılmıştır. Her parselden 5 bitki tesadüfen alınmış ve üç tekrarlamalı olarak yapılan ölçümlerde, her ölçüm için toplam J 5 bitki kullanılmıştır. Buğday bitkisinin boyunun zamana göre modellenınesi ve model parametrelerinin tahmini uygulaına yönünden önem arzetmektedir. Bu amaçla, doğrusal olmayan bir model gösteren bitkinin boy uzunluğu ile zaman ilişkisi, belli noktalarda zıplamalar gösterirken bazı noktalarda kesilmeler gösterebilmektedir. Bu çalışmamızda buğday bitkisinin boy uzunluğu ve zaman ilişkisi açısından parçalı regresyon modelinin parametre tahmini ve zıplama noktalarının tahmin edilmesi ele alınmıştır

  14. Pédagogie et apprentissage par projet : cas des projets d'innovation réalisés dans le cadre d'un partenariat industriel

    OpenAIRE

    Claude, Sylvain; Ponchon, Camille; Maison, Marie; Boulon, Pascal; Muniglia, Lionel; Cuq, Bernard

    2015-01-01

    International audience Project-based learning is fully implemented in the curricula of French higher education institutions in agribusiness. For 15 years, twelve institutions have developed operational teaching approaches to integrate in their education curriculum participation of students in the food eco-innovation contest ECOTROPHELIA. Created in 2000, the contest succeeds in mobilizing and facilitating cooperation between higher education and representatives of the food sector to train ...

  15. Calorimetric determination of the enthalpy of formation and the description of the constitutional defects of the ordered (Ni, Co)1-yAly phase

    International Nuclear Information System (INIS)

    The enthalpy of formation of the ordered phase (NixCo1-x)0.50Al0.50, (NixCo1-x)0.58Al0.42 with (0 ≤ x ≤ 1) and Ni0.30Co0.15Al0.55 with the B2 (CsCl) structure was measured by differential solution calorimetry at 1073 K as a function of composition in order to describe the constitutional defects. The binary Ni0.50Al0.50-phase exhibits the most negative enthalpy of formation (-71.27 kJ mol-1). The absolute value of the enthalpy of formation decreases by substituting nickel for cobalt with constant aluminium content. The composition dependence of the enthalpy of formation can be described by the disorder model of Wagner and Schottky. The model provides information about the composition dependence of the concentration of the existing defects (vacancy, antistructure atom) of the ordered ternary phases. (orig.)

  16. Excitonic localization in AlN-rich AlxGa1−xN/AlyGa1−yN multi-quantum-well grain boundaries

    KAUST Repository

    Ajia, Idris A.

    2014-09-22

    AlGaN/AlGaN multi-quantum-wells (MQW) with AlN-rich grains have been grown by metal organic chemical vapor deposition. The grains are observed to have strong excitonic localization characteristics that are affected by their sizes. The tendency to confine excitons progressively intensifies with increasing grain boundary area. Photoluminescence results indicate that the MQW have a dominant effect on the peak energy of the near-bandedge emission at temperatures below 150 K, with the localization properties of the grains becoming evident beyond 150 K. Cathodoluminescence maps reveal that the grain boundary has no effect on the peak intensities of the AlGaN/AlGaN samples.

  17. Reply to Aitchison and Ali: Reconciling Himalayan ophiolite and Asian magmatic arc records with a two-stage India-Asia collision model

    NARCIS (Netherlands)

    van Hinsbergen, D.J.J.; Lippert, P.C.; Dupont-Nivet, G.; McQuarrie, N.; Doubrovine, P.V.; Spakman, W.; Torsvik, T.H.

    2012-01-01

    We recently presented a compilation of paleomagnetic data arguing for Cretaceous extension within Greater India. These data imply that a Tibetan Himalayan (TH) microcontinent rifted away from India, opening an oceanic Greater India Basin (GIB) in its wake. Consequently, we postulated a two-stage Ind

  18. DIDAKTIČNA MAPA ZA POUČEVANJE GEOGRAFIJE AVSTRALIJE IN POLARNIH OBMOČIJ PRI POUKU S SLEPIM ALI SLABOVIDNIM UČENCEM

    OpenAIRE

    Vrčkovnik, Mateja

    2016-01-01

    Slepi in slabovidni otroci predstavljajo skupino otok s posebnimi potrebami, ki imajo okvaro vidne funkcije. Slovenija spada po pojavnosti slepote v evropsko povprečje. Slabovidnost je pogostejši pojav kot slepota, tako pri mlajših kot tudi pri starejših, vendar pa se delež teh povečuje. Slepi in slabovidni so prikrajšani za vizualno spoznavanje in doživljanje sveta okoli sebe, zato informacije okoli sebe pridobivajo predvsem z drugimi čutili. Vse več slepih in slabovidnih otrok se z dana...

  19. Bez čvrstih stavova, ali s mnogo zahtjeva: čvrstoća uvjerenja i želja za označavanjem genetski modificirane hrane

    OpenAIRE

    Radas, Sonja; Teisl, Mario

    2007-01-01

    Postoje dva oprečna stajališta u odnosu na prihvaćanje genetski modificirane hrane (GM) i želje potrošača za označavanjem tih proizvoda. S jedne strane, postoji mišljenje kako potrošači nisu zainteresirani i kako stoga ne postoji želja za označavanjem GM proizvoda. Drugi se protive tom stavu. Podvojena mišljenja možda nastaju kao posljedica činjenice da u svakodnevnom životu potrošači mogu razlikovati više mogućnosti nego što se to u istraživanjima razmatra. Istodobno, potrošači mogu na razli...

  20. Influence of inelastic collisions with hydrogen atoms on the formation of AlI and SiI lines in stellar spectra

    Science.gov (United States)

    Mashonkina, L. I.; Belyaev, A. K.; Shi, J.-R.

    2016-06-01

    We have performed calculations by abandoning the assumption of local thermodynamic equilibrium (within the so-called non-LTE approach) for Al I and Si I with model atmospheres corresponding to stars of spectral types F-G-Kwith differentmetal abundances. To take into account inelastic collisions with hydrogen atoms, for the first time we have applied the cross sections calculated by Belyaev et al. using model approaches within the formalism of the Born-Oppenheimer quantum theory. We show that for Al I non-LTE leads to higher ionization (overionization) than in LTE in the spectral line formation region and to a weakening of spectral lines, which is consistent with earlier non-LTE studies. However, our results, especially for the subordinate lines, differ quantitatively from the results of predecessors. Owing to their large cross sections, the ion-pair production and mutual neutralization processes Al I( nl) + HI(1 s) ↔ Al II(3 s 2) + H- provide a close coupling of highly excited Al I levels with the Al II ground state, which causes the deviations from the equilibrium level population to decrease compared to the calculations where the collisions only with electrons are taken into account. For three moderately metal-deficient dwarf stars, the aluminum abundance has been determined from seven Al I lines in different models of their formation. Under the assumption of LTE and in non-LTE calculations including the collisions only with electrons, the Al I 3961 ˚A resonance line gives a systematically lower abundance than the mean abundance from the subordinate lines, by 0.25-0.45 dex. The difference for each star is removed by taking into account the collisions with hydrogen atoms, and the rms error of the abundance derived from all seven Al I lines decreases by a factor of 1.5-3 compared to the LTE analysis. We have calculated the non- LTE corrections to the abundance for six subordinate Al I lines as a function of the effective temperature (4500 K ≤ T eff ≤ 6500 K), surface gravity (3.0 ≤ log g ≤ 4.5), and metal abundance ([M/H] = 0, -1, -2, and -3). For Si I including the collisions with HI leads to the establishment of equilibrium populations in the spectral line formation region even in hot metal-deficient models and to vanishingly small departures from LTE in spectral lines.

  1. AnAlySiS of CoAlbed GAS CompoSition in GAS SAmple%瓦斯样品中气体成分分析

    Institute of Scientific and Technical Information of China (English)

    夏峰; 赵兰芳; 聂全新

    2015-01-01

    将野外装入解吸罐中的煤芯样,用真空脱气装置脱气,脱出的气体通过GC4008B气相色谱仪进行组份浓度测定,记录的数据经A5000气相色谱工作站数据处理软件处理。从而快速、准确地测定出CO、CO2、CH4、C2H4、C2H6、C3H8以及重烃等气体成分的含量。用于大批量实际样品测定,符合质量管理的要求。%Put coal core sample in analysis tank in the field and degassed it in a vacuum degasser. The gas product was determined for its compositional concentration with gas chromatograph GC4008B. Recorded data was processed with A5000 gas chromatograph workstation data processing software. It was fast to measure the contents of CO, CO2, CH4, C2H4, C2H6, C3H8 and heavy hydrocarbon gases. It meets the quality requirement when used for measurement of samples in large quantities.

  2. First principles study of structural, elastic, electronic and magnetic properties of Mn-doped AlY (Y=N, P, As) compounds

    Energy Technology Data Exchange (ETDEWEB)

    Sajjad, M. [School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876 (China); Alay-e-Abbas, S.M. [Department of Physics, University of Sargodha, Sargodha 40100 (Pakistan); Department of Physics, Government College University, Faisalabad, Allama Iqbal Road, Faisalabad 38000 (Pakistan); Zhang, H.X. [School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876 (China); Beijing Key Laboratory of Work Safety Intelligent Monitoring (Beijing University of Posts and Telecommunications), Beijing 100876 (China); Noor, N.A. [Centre for High Energy Physics, University of the Punjab, Quaid-e-Azam Campus, 54590 Lahore (Pakistan); Saeed, Y. [Department of Physics, Government College University, Faisalabad, Allama Iqbal Road, Faisalabad 38000 (Pakistan); Shakir, Imran [Deanship of scientific research, College of Engineering, King Saud University, P. O. BOX 800, Riyadh 11421 (Saudi Arabia); Shaukat, A., E-mail: schaukat@gmail.com [Department of Physics, University of Sargodha, Sargodha 40100 (Pakistan)

    2015-09-15

    We investigate zinc-blende phase Al{sub 0.75}Mn{sub 0.25}Y (Y=N, P, As) compounds using full-potential linear-augmented-plane wave plus local-orbital method. For computing structural and elastic properties the Generalized Gradient Approximation (GGA) has been used; whereas the electronic and magnetic properties are examined at the optimized GGA lattice parameters by employing modified Becke and Johnson local density approximation. All these compounds are found to be stable in ferromagnetic ordering in the zinc-blende structure which is supported by the computed elastic constants. The nature of electronic band structure are calculated and the nature of band gaps in the doped system is analyzed. The results are examined to identify exchange mechanism which is the main source of introducing ferromagnetism in the compounds under investigation. Spin charge density contour plots in the (1 1 0) plane and the evaluation of s–p and p–d exchange constants (N{sub 0}α and N{sub 0}β) are evaluated for understanding bonding and exchange splitting process, respectively. - Highlights: • Spin-polarized DFT investigation Mn-doped AlN, AlP and AlAs is reported. • Structrual and elastic properites are computed for evaluating stability. • mBJLDA used for appropriate treatment of d states of Mn for electronic properties. • Half metallicity, ferromagnetic stability and exchange constants are evaluated.

  3. Identifying the Effect of the Old Neighborhoods İdentity on the Consent of the Living Environment (Case Study: Ali Gholi Agha and Vali Asr Neighborhood in Esfahan)

    OpenAIRE

    MOAKHAR, Elnaz Khadem; GHARAEI, Fariba; ESFAHANI, Morvarid Ghasemi; KHADEM, Hamid

    2015-01-01

    A lot of cities in Iran including Esfahan have a significant old history, and the inner parts of the city is historically valuable, but the exogenous growth, adding multiple functions in different parts of the city, and its expansion caused the neighborhoods gradually experienced problems. Fortunately, most of these neighborhoods in Esfahan have retained their identities and people still keep the sense of belonging to the neighborhoods. But today, some neighborhoods are emerging which except ...

  4. Development of Chromatographic Fingerprints of Eurycoma longifolia (Tongkat Ali) Roots Using Online Solid Phase Extraction-Liquid Chromatography (SPE-LC).

    Science.gov (United States)

    Zaini, Nor Nasriah; Osman, Rozita; Juahir, Hafizan; Saim, Norashikin

    2016-04-30

    E. longifolia is attracting interest due to its pharmacological properties and pro-vitality effects. In this study, an online SPE-LC approach using polystyrene divinyl benzene (PSDVB) and C18 columns was developed in obtaining chromatographic fingerprints of E. longifolia. E. longifolia root samples were extracted using pressurized liquid extraction (PLE) technique prior to online SPE-LC. The effects of mobile phase compositions and column switching time on the chromatographic fingerprint were optimized. Validation of the developed method was studied based on eurycomanone. Linearity was in the range of 5 to 50 µg∙mL(-1) (r² = 0.997) with 3.2% relative standard deviation of peak area. The developed method was used to analyze 14 E. longifolia root samples and 10 products (capsules). Selected chemometric techniques: cluster analysis (CA), discriminant analysis (DA), and principal component analysis (PCA) were applied to the fingerprint datasets of 37 selected peaks to evaluate the ability of the chromatographic fingerprint in classifying quality of E. longifolia. Three groups were obtained using CA. DA yielded 100% correlation coefficient with 19 discriminant compounds. Using PCA, E. longifolia root samples were clearly discriminated from the products. This study showed that the developed online SPE-LC method was able to provide comprehensive evaluation of E. longifolia samples for quality control purposes.

  5. Controlling the compositional inhomogeneities in AlxGa1-xN/AlyGa1-yN MQWs grown by PA-MBE: Effect on luminescence properties

    Science.gov (United States)

    Pramanik, Pallabi; Sen, Sayantani; Singha, Chirantan; Roy, Abhra Shankar; Das, Alakananda; Sen, Susanta; Bhattacharyya, Anirban; Kumar, Deepak; Sridhara Rao, D. V.

    2016-04-01

    Al0.35Ga0.65N/Al0.55Ga0.45N MQWs were grown by PA-MBE using a range of group III/V flux ratios. TEM images indicate sharp interfaces and well/barrier widths of 1.5/2 nm. We observe that small variations of group III/V flux ratio cause dramatic variations in the room temperature photoluminescence (PL) spectra. In addition to band edge luminescence, multiple low energy PL peaks are observed for growths under excess group III conditions, which are absent for near-stoichiometric growth. Temperature dependent PL measurements indicate that at room temperature, emission occurs due to transitions at potential fluctuations generated by the presence of compositional inhomogeneity. These effects are dominant for growth under excess group III conditions due to the presence of a metallic layer on the growth surface during deposition. This can be eliminated by the use of an Indium surfactant during growth, which modifies the diffusion length of Ga and Al adatoms. Under these conditions, the optical properties of MQWs are relatively insensitive to variations in group III to V flux ratio and hence substrate temperature, thus making them suitable for industrial-scale fabrication of optoelectronic devices in the ultraviolet range.

  6. 一种新型通用全数字时钟匀滑技术%A Novel Universal Ali-Digital Clock Smoothness Technique

    Institute of Scientific and Technical Information of China (English)

    秦晓懿; 王瀚晟; 曾烈光

    2001-01-01

    针对锁相环在匀滑含有低频大幅度的抖动和漂移的时钟时有诸如同步和捕捉范围很窄、容易失锁等缺点,提出了一种新的全数字时钟匀滑技术一统计预测法.其主要思想是用一个周期的统计结果来预测下一个周期的处理值.从该方法的原理和性能分析可知,其可有效的匀滑各种抖动和漂移,抖动积累较小,同步和捕捉范围很宽,可以匀滑不同频率的时钟.另外,改进的变周期的统计预测法也可使捕捉时间降到合适的长度,以适用于不同场合.

  7. Težave z zaposlovanjem mladih, ki so bili v otroštvu ali zgodnji mladosti zdravljeni zaradi raka

    OpenAIRE

    Babič, Janja

    2015-01-01

    A malign illness and its treatment in childhood or adolescence may be immediately or eventually followed by physical or mental consequences. The impact of the illness on the quality ofends upon the type of consequence and upon the response of the former patient, as well as of society, to the illness and to its consequences. The undesired results include difficulties in schooling, in the search of employment, and at work. The percentage of persons with difficulties in finding employment and at...

  8. Ö?RETMEN ADAYLARININ ÖZ YETERLYK YNANÇLARI ve EPYSTEMOLOJYK YNANÇLARI ÜZERYNE BYR ÇALI?MA

    OpenAIRE

    Gürol, Aysun

    2010-01-01

    This study addresses prospective teachers' self-efficacy beliefs and epistemological beliefs in terms of such variables as gender, type of high school, branches of them at high school and their departments at the university and whether there is a significant relation between these beliefs. Descriptive method was used in the study. Study group is composed of fourth-grade students continuing their education in various departments at the Faculty of Education, at Fyrat University. Data collected ...

  9. Evaluation of radiologic findings in neonates with hirschprung's disease, referred to Boo-Ali Sina Hospital in Sari between 2008 and 2009

    OpenAIRE

    Abdolrasoul Alaee; Zoha Mehrara; Arezou Nozari

    2009-01-01

    (Received 9 September, 2009 ; Accepted 9 November, 2009)AbstractBackground and purpose: Diagnosis of Hirschprung's disease is one of the most important problems of pediatric surgeons and leaving it without treatment has its own complications. Early diagnosis in younger age with special attention to clinical and radiological findings can reduce these complications. The aim of this study was to compare the findings of plain abdominal radiography and contrast enema in neonates with Hirschprung's...

  10. Suivi de l'eutrophisation en Baie de Douarnenez - Estimation de la biomasse en algues vertes (Mission réalisée le 1° aout 1996)

    OpenAIRE

    1996-01-01

    La mission menée dans le cadre du programme concernant le suivi de l'eutrophisation en baie de Douarnenez s'est déroulée le 1er août 1996. Ce travail fait partie d'un programme de lutte contre les marées vertes, coordonné par l'IFREMER et le CEMAGREF dans le cadre du Contrat de Plan Etat-Région et intitulé : Bassins versants et transmission des pollutions au littoral. Cette mission comprenant les prises de vues aériennes et les échantillonnages de terrain s'est déroulée lors d'un coefficient ...

  11. Development of Chromatographic Fingerprints of Eurycoma longifolia (Tongkat Ali) Roots Using Online Solid Phase Extraction-Liquid Chromatography (SPE-LC).

    Science.gov (United States)

    Zaini, Nor Nasriah; Osman, Rozita; Juahir, Hafizan; Saim, Norashikin

    2016-01-01

    E. longifolia is attracting interest due to its pharmacological properties and pro-vitality effects. In this study, an online SPE-LC approach using polystyrene divinyl benzene (PSDVB) and C18 columns was developed in obtaining chromatographic fingerprints of E. longifolia. E. longifolia root samples were extracted using pressurized liquid extraction (PLE) technique prior to online SPE-LC. The effects of mobile phase compositions and column switching time on the chromatographic fingerprint were optimized. Validation of the developed method was studied based on eurycomanone. Linearity was in the range of 5 to 50 µg∙mL(-1) (r² = 0.997) with 3.2% relative standard deviation of peak area. The developed method was used to analyze 14 E. longifolia root samples and 10 products (capsules). Selected chemometric techniques: cluster analysis (CA), discriminant analysis (DA), and principal component analysis (PCA) were applied to the fingerprint datasets of 37 selected peaks to evaluate the ability of the chromatographic fingerprint in classifying quality of E. longifolia. Three groups were obtained using CA. DA yielded 100% correlation coefficient with 19 discriminant compounds. Using PCA, E. longifolia root samples were clearly discriminated from the products. This study showed that the developed online SPE-LC method was able to provide comprehensive evaluation of E. longifolia samples for quality control purposes. PMID:27144555

  12. Hospital contacts for endocrine disorders in Adult Life after Childhood Cancer in Scandinavia (ALiCCS): a population-based cohort study

    DEFF Research Database (Denmark)

    de Fine Licht, Sofie; Winther, Jeanette Falck; Gudmundsdottir, Thorgerdur;

    2014-01-01

    BACKGROUND: The pattern of endocrine disorders in long-term survivors of childhood cancer has not been investigated comprehensively. Here, we aimed to assess the lifetime risk of these disorders in Nordic survivors of childhood cancer. METHODS: From the national cancer registries of Denmark...... were linked to the national hospital registries, and observed numbers of first-time hospital contacts for endocrine disorders in survivors of childhood cancer were compared with the expected numbers derived from the population comparison cohort. We calculated the absolute excess risks attributable...... to status as a childhood cancer survivor and standardised hospitalisation rate ratios (SHRRs). FINDINGS: Of the childhood cancer survivors, 3292 had contact with a hospital for an endocrine disorder, yielding a SHRR of 4·8 (95% CI 4·6-5·0); the highest risks were in survivors of leukaemia (SHRR 7·3 [95% CI...

  13. Carrier-carrier scattering in the gain dynamics of InxGa1-xAs/AlyGa1-yAs diode lasers

    DEFF Research Database (Denmark)

    Sanders, Gary D; Sun, C.-K.; Golubovic, B.;

    1996-01-01

    Ultrafast optical nonlinearities in semiconductors play a central role in determining transient amplification and pulse-dependent gain saturation in diode lasers. Both carrier-phonon and carrier-carrier scattering are expected to determine the gain dynamics in these systems. We present a relaxation......-Dirac function where the chemical potential and temperature are self-consistently chosen so that both particle number and energy are conserved in the carrier-carrier scattering process. The relaxation approximation makes the problem an effective one-dimensional problem which can then be solved directly for the...

  14. Impacts du changement climatique sur les calendriers agricoles : Exemples de cultures céréalières du Plateau lorrain

    OpenAIRE

    Fournier, Thomas; De La Torre, Claudia

    2015-01-01

    Cette étude conduite pour déterminer si les cycles des céréales sont modifiés avec le changement climatique, articule pour la première fois les conduites menées par les agriculteurs du Nord-Est de la France et celles de gestionnaires de dispositifs d’expérimentation agronomique. Menée en Lorraine, elle essaie de tester l'hypothèse formulée en Finlande en 2008: les dates de semis et de récolte sont avancées. Les calendriers culturaux sont examinés avec deux méthodes : (i) des enquêtes chez 12 ...

  15. Iranian supplier HEPCO receives CMS Gold Award: Ali Mohammad Rafiee (left) from HEPCO receives the CMS Gold Award from CMS spokesman Michel Della Negra.

    CERN Multimedia

    Patrice Loïezi

    2004-01-01

    As part of the fifth annual CMS awards, Iranian contractor HEPCO has received a Gold Award, for top suppliers, in a ceremony held on 14 June. HEPCO received the award for the excellent quality of work in constructing two 20 tonne support tables, two 75 tonne shields and supporting brackets to lower the Hadron Forward Calorimeter into the CMS detector cavern, to tolerances that were very difficult in structures of this size.

  16. Barriers of the Development of Web-Based Training in Agricultural Higher Education System in Iran: A Case Study of Hamadan Bu Ali Sina University, Iran

    Science.gov (United States)

    Saadi, Heshmatollah; Mirzayi, Khalil; Movahedi, Reza

    2016-01-01

    Recently, higher education systems seek to use network-based and Internet-based information technologies in education, teaching and learning. E-learning in Iran higher education system has been started since 2003, however, its development has been very slow. The present study is a survey research. The participants of the study are faculty members,…

  17. Siserände suundumused 20. sajandil = Trends of internal migration during the 20th century and at the beginning of the 21st century / Alis Tammur

    Index Scriptorium Estoniae

    Tammur, Alis

    2008-01-01

    Siserände suundadest Eestis alates 1920ndatest aastatest kuni 2007. aastani. Kaart: Linnadesse tulnud endise alalise elukoha järgi, 1922-1934. Graafik: Siserände vanusjaotus. Tabel: Linnade ja maa-asulate vahelised rändesuunad 2000-2007

  18. First principles study of structural, elastic, electronic and magnetic properties of Mn-doped AlY (Y=N, P, As) compounds

    International Nuclear Information System (INIS)

    We investigate zinc-blende phase Al0.75Mn0.25Y (Y=N, P, As) compounds using full-potential linear-augmented-plane wave plus local-orbital method. For computing structural and elastic properties the Generalized Gradient Approximation (GGA) has been used; whereas the electronic and magnetic properties are examined at the optimized GGA lattice parameters by employing modified Becke and Johnson local density approximation. All these compounds are found to be stable in ferromagnetic ordering in the zinc-blende structure which is supported by the computed elastic constants. The nature of electronic band structure are calculated and the nature of band gaps in the doped system is analyzed. The results are examined to identify exchange mechanism which is the main source of introducing ferromagnetism in the compounds under investigation. Spin charge density contour plots in the (1 1 0) plane and the evaluation of s–p and p–d exchange constants (N0α and N0β) are evaluated for understanding bonding and exchange splitting process, respectively. - Highlights: • Spin-polarized DFT investigation Mn-doped AlN, AlP and AlAs is reported. • Structrual and elastic properites are computed for evaluating stability. • mBJLDA used for appropriate treatment of d states of Mn for electronic properties. • Half metallicity, ferromagnetic stability and exchange constants are evaluated

  19. WikiLeaks teroristična organizacija - da ali ne? : diplomsko delo visokošolskega strokovnega študija Varnost in policijsko delo

    OpenAIRE

    Livojević, Luka

    2013-01-01

    V diplomski nalogi je prikazan celotne potek afere WikiLeaks, pred in po izdaji tajnih dokumentov. V prvem delu sem napisal nekaj on internetnem terorizmu in tajnih dokumentih za lažje razumevanje diplomske naloge. Kaj je to kibernetski prostor in kako se ga uporablja. V nadaljevanju sem prešel na glavnega akterja zgodbe Juliana Assangeea. Opisal sem njegovo odraščanje in mladost, ki je imelo nanj velik vpliv. Prav zaradi nenehnih selitev v mladosti je bil pripravljen zapustiti mesto, s...

  20. Structural and Electrochemical Investigation of Li(Ni0.4Co0.2-yAlyMn0.4)O2 Cathode Material

    Energy Technology Data Exchange (ETDEWEB)

    Rumble, C.; Conry, T.E.; Doeff, Marca; Cairns, Elton J.; Penner-Hahn, James. E.; Deb, Aniruddha

    2010-02-02

    Li(Ni{sub 0.4}Co{sub 0.2-y}Al{sub y}Mn{sub 0.4})O{sub 2} with y=0.05 was investigated to understand the effect of replacement of the cobalt by aluminum on the structural and electrochemical properties. The effect of the substitution was studied by in-situ X-ray absorption spectroscopy (XAS), utilizing a novel in situ electrochemical cell, specifically designed for long-term X-ray experiments. The cell was cycled at a moderate rate through a typical Li-ion battery operating voltage range (1.0-4.7 V). XAS measurements were performed at different states-of-charge (SOC) during cycling, at the Ni, Co, and the Mn edges, revealing details about the response of the cathode to Li insertion and extraction processes. The extended X-ray absorption fine structure region of the spectra revealed the changes of bond distance and coordination number of Ni, Co, and Mn absorbers as a function of the SOC of the material. The oxidation states of the transition metals in the system are Ni{sup 2+}, Co{sup 3+}, and Mn{sup 4+} in the as-made material (fully discharged), while during charging the Ni{sup 2+} is oxidized to Ni{sup 4+} through an intermediate stage of Ni{sup 3+}, Co{sup 3+} is oxidized towards Co{sup 4+} and Mn was found to be electrochemically inactive and remains as Mn{sup 4+}. The EXAFS results during cycling show that the Ni-O changes the most, followed by Co-O and Mn-O varies the least. These measurements on this cathode material confirmed that the material retains its symmetry and good structural short-range order leading to the superior cycling reported earlier.

  1. Structural and electrochemical Investigation of Li(Ni0.4Co0.2-yAlyMn0.4)O2 Cathode Material

    Energy Technology Data Exchange (ETDEWEB)

    Rumble, C.; Conry, T.E.; Doeff, Marca; Cairns, Elton J.; Penner-Hahn, James E.; Deb, Aniruddha

    2010-06-14

    Li(Ni{sub 0.4}Co{sub 0.15}Al{sub 0.05}Mn{sub 0.4})O{sub 2} was investigated to understand the effect of replacement of the cobalt by aluminum on the structural and electrochemical properties. In situ X-ray absorption spectroscopy (XAS) was performed, utilizing a novel in situ electrochemical cell, specifically designed for long-term X-ray experiments. The cell was cycled at a moderate rate through a typical Li-ion battery operating voltage range. (1.0-4.7 V) XAS measurements were performed at different states of charge (SOC) during cycling, at the Ni, Co, and the Mn edges, revealing details about the response of the cathode to Li insertion and extraction processes. The extended X-ray absorption fine structure (EXAFS) region of the spectra revealed the changes of bond distance and coordination number of Ni, Co, and Mn absorbers as a function of the SOC of the material. The oxidation states of the transition metals in the system are Ni{sup 2+}, Co{sup 3+}, and Mn{sup 4+} in the as-made material (fully discharged), while during charging the Ni{sup 2+} is oxidized to Ni{sup 4+} through an intermediate stage of Ni{sup 3+}, Co{sup 3+} is oxidized toward Co{sup 4+}, and Mn was found to be electrochemically inactive and remained as Mn{sup 4+}. The EXAFS results during cycling show that the Ni-O changes the most, followed by Co-O, and Mn-O varies the least. These measurements on this cathode material confirmed that the material retains its symmetry and good structural short-range order leading to the superior cycling reported earlier.

  2. S tatu s a n dC omparativ e An aly sis of Overseas Upstream Businesses of China'sOil Majors%S tatu s a n dC omparativ e An aly sis of Overseas Upstream Businesses of China'sOil Majors

    Institute of Scientific and Technical Information of China (English)

    LiYushun

    2012-01-01

    In recent years, China's three oil majors has taken .the opportunity of rising oil price and financialcrisis, implemented the "going out" strategy and done international businesses. They have been actively engaged in overseas oil/gas development and petroleum engineering services. They have completed market existence in overseas upstream business successively and their overseas upstream business is on a fast track of development.

  3. BORÇALI VE ÇILDIR KARAPAPAK / TEREKEME AĞZI SÖZ VARLIĞININ ALINTI SÖZCÜKLER AÇISINDAN KARŞILAŞTIRILMASI / THE COMPARISON OF QUOTED WORDS IN BORÇALI AND ÇILDIR KARAPAPAK / TEREKEME DIALECT

    Directory of Open Access Journals (Sweden)

    Bahadır GÜNEŞ

    2015-09-01

    Full Text Available Bu çalışmada Borçalı ve Çıldır Karapapak / Terekeme ağzındaki alıntı sözcükler, ilgili yörelerden tarafımızca ses kayıt cihazı yardımıyla ve not alarak derlenen metinlerden hareketle karşılaştırmalı olarak gösterilecektir. Bunun yapılmasındaki en önemli neden, söz konusu çalışmanın eş zamanlı ve karşılaştırmalı olmasıdır. Bu nedenle aynı zaman diliminde derlenen metinlerden yararlanılmıştır. Bir başka deyişle ilgili yörelerden daha önce derlenen metinlerin söz varlığına burada yer verilmemiştir. Bu çalışma, anılan yörelerin söz varlığını bütünüyle ortaya koyma iddiası taşımamaktadır. Aynı kökene sahip Türklerin farklı coğrafya, kültür, siyasi ve sosyal alanlarda varlık gösteren ağızlarındaki söz varlığının eş zamanlı ve karşılaştırmalı olarak nasıl bir sonuç vereceğine dair bir ipucu elde etme düşüncesi hâkimdir. / In this study Borçalı and Çıldır Karapapak / Terekeme quoted words will be shown in comparison related places by us with the help of voice recorder and taking notes compiled text of the support. The study simultaneously and is comparatively the most important reason for this. Therefore, it is used also compiled texts. That does not existence of an earlier text. This study does not specify all of the vocabulary of the places. Karapapak / Terekeme Turkish different geographies, cultures, simultaneously indicating the presence of vocabulary in the dialect in political and social fields and the idea that how to get a result as compared.

  4. Double stars measurements with cheap CCD sensors (French Title: Mesures d'étoiles doubles visuelles réalisées à l'aide de capteurs dtc de grande diffusion)

    Science.gov (United States)

    Losse, F.

    2005-09-01

    This paper presents 262 measurements of visual binaries. They essentially come from a three years evaluation period of cheap CCD sensors coupled with either off the shelves or modified webcam electronics. The evaluation cycle and results are largely described in Bulletin n°40 de la Commission des Etoiles Doubles (Sept. 2002 - Société Astronomique de France). These devices can produce measurements as consistent as those obtained with a filar micrometer on the same 8" telescope. The most recent measurements (epoch 2004+) were obtained with an "Audine" camera shipped with a KAF400. Besides the stars visited for evaluation purpose, we present some systems of interest : 17 orbital binaries, 35 neglected systems, 15 confirmations and 2 discoveries of a third component in already known systems.

  5. Incidences des normes de conception sur la sécurié routière. Recherche réalisée pour la Commission Européenne (DG VII).

    NARCIS (Netherlands)

    Ruyters, H.G.J.C.M. Slop, M. & Wegman, F.C.M. (eds.)

    1994-01-01

    This report describes the results of a study carried out for the European Union. The report uses the safety principle that: (i) proper road design is crucial to prevent human errors in traffic; and (ii) less human errors will result in less accidents. The study contains the following parts: (1) gath

  6. Ali stanje lišajske flore že kaže na spremembo kakovosti zraka v Šaleški dolini po izgradnji čistilnih naprav v termoelektrarni Šoštanj?

    OpenAIRE

    Savšek, Simona; Ambrožič, Tomaž; Stopar, Bojan; Turk, Goran; Poličnik, Helena; Franc BATIČ

    2016-01-01

    Lišaje zaradi njihove specifične biologije pogosto uporabljamo kot bioindikatorje kvalitete zraka. Njihova steljka je brez pravih tkiv in organov, nimajo razvite kutikule in korenin. Vse, kar potrebujejo za svojo rast in razvoj, črpajo iz zraka. Epifitske lišaje uporabljamo za (1) sledenje vnosa težkih kovin v okolje, saj se težke kovine v njih kopičijo, ter (2) za sledenje splošne onesnaženosti zraka, saj lišaji na območjih večjega onesnaženja začnejo propadati. Na območju Šaleške doline smo...

  7. 双排龈技术在CAD/CAM全瓷修复中的临床应用%Clinical application of double gingival retraction technique for ali- ceramic restorations of CAD / CAM.

    Institute of Scientific and Technical Information of China (English)

    孙珍; 许晓波; 边华琴

    2011-01-01

    Objection: To evaluate double gingival retraction technique of all-ceramic restorations in CAD/CAM.Method: 30 patients,48 restorations in CAD/CAM were used with double gingival retraction technique, observed gingival、prepared tooth, digital impression and all-ceramic restoration. Result: The rates of satisfaction with double gingival retraction were 97.91%,95.83 % and 100 %. Conclusion:Double gingival retraction technique was an effective method in CAD/CAM restoration.%目的:评价双排龈技术在CAD/CAM全瓷修复中的临床应用效果.方法:对30例48单位前牙行CAD/CAM全瓷修复,牙体预备后采用双排龈技术进行排龈,检查牙龈及预备体、光学印模以及修复体边缘情况.结果:双排龈技术的满意率分别为97.91%,95.83%,100.0%.结论:双排龈技术在CAD/CAM全瓷修复时具有很好的应用效果.

  8. Improvement orange–red emitting by codoping A{sup +} (A=Li, Na, K) in Ca{sub 2}BO{sub 3}Cl:Sm{sup 3+}phosphor

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhijun, E-mail: wangzhijunmail@yahoo.com.cn [College of Physics Science and Technology, Hebei University, Baoding 071002 (China); Li, Panlai; Zhang, Xing; Li, Qingxuan; Li, Ting; Yang, Zhiping; Guo, Qinglin [College of Physics Science and Technology, Hebei University, Baoding 071002 (China)

    2013-04-01

    Sm{sup 3+} doped Ca{sub 2}BO{sub 3}Cl with different charge compensation approaches are synthesized by a high temperature solid state reaction method, and systematically characterized by the luminescent properties and the CIE chromaticity coordinates. All the samples show the characteristics orange–red emission of Sm{sup 3+} ion with good CIE chromaticity coordinates. When codoped Li{sup +}, Na{sup +}, K{sup +} as charge compensators, the relative emission intensities of Ca{sub 2}BO{sub 3}Cl:Sm{sup 3+} are increased to 1.57, 1.99 and 1.78 times that of the direct charge balance. The difference is considered to be due to the different ion radii effect on the crystal field of Sm{sup 3+} ions. The results indicate that Na{sup +} ion may be the optimal compensation charge for Ca{sub 2}BO{sub 3}Cl:Sm{sup 3+}.

  9. 对支付宝快捷支付事件的经济法律解读%An Explanation of Ali-Pay’s Quick Payment from the Angle of Economics and Law

    Institute of Scientific and Technical Information of China (English)

    黎四奇

    2014-01-01

    就事物的发展而言,问题本身并不会阻碍事物的发展。然而,如果一个问题的解决是以理念与方法都错位的方式处理时,那么它不仅会使问题晦涩化,而且也会扰乱与问题相关的社会关系,从而导致资源配置的低下与正义目的的落空。对于快捷支付的是非,只有置于市场自由、竞争、创新、国家权力的边界等基点上,并本着问题的解决必须给未来发展留下空间的新思维,才可能形成理性且富有效率的答案。%As far as the development is concerned, problem itself is not the barrier for its evolution. However, if a problem is solved in a wrong way or incorrect doctrine, it will not only make the problem more troublesome, but also disturb the social order connected with it, and lead to the inefficiency of resources and failure of justice. Regarding the quick payment, only on the basis of market freedom, competition, innovation, conifnes of state power and considering the future development in dealing with problem can produce the reasonable and efifcient answer.

  10. Neplačevanje prispevkov s strani delodajalca - prekršek ali kaznivo dejanje? : diplomsko delo visokošolskega strokovnega študija Varnost in policijsko delo

    OpenAIRE

    Jenkole, Maša

    2012-01-01

    Prispevki za socialno varnost so sredstva, ki jih morajo delodajalci in delojemalci plačevati mesečno. Ti prispevki se plačujejo v odstotkih od bruto plače. Plačujejo se do petnajstega v mesecu za pretekli mesec. Gospodarska kriza je dobro prispevala k temu, da veliko gospodarskih družb ni plačevalo prispevkov za socialno varnost svojim delavcem. Za vsakogar je pomembno, da se zaveda svojih pravic, ki mu v delovnem razmerju pripadajo. Ena izmed teh pravic so tudi pravice, ki jih pridobi za...

  11. Comment on 'Artificial neural network based modeling of heated catalytic converter performance' by M. Ali Akcayol and Can Cinar [Applied Thermal Engineering 25 (2005) 2341

    Energy Technology Data Exchange (ETDEWEB)

    Sha, W. [Metals Research Group, School of Planning, Architecture and Civil Engineering, The Queen' s University of Belfast, Belfast BT7 1NN (United Kingdom)

    2007-02-15

    A paper has been published in Applied Thermal Engineering, using feed-forward artificial neural network (ANN) in the modeling of heated catalytic converter performance. The present paper attempts to discuss and comment on the paper. The amount of data used in the paper are not enough to determine the number of fitting parameters in the network. Therefore, the model is not mathematically sound or justified. The conclusion is that ANN modeling should be used with care and enough data. (author)

  12. KAİZEN MALİYETLEME SİSTEMİ : DİNAMİK BİR MALİYET YÖNETİMİ SİSTEMİ Öğr.Gör.Dr. Ali ALTINBAY

    OpenAIRE

    ,

    2006-01-01

    Kaizen Maliyetleme Sistemi, “yalın muhasebe” kavramı içerisinde yeralan maliyet yönetim sistemlerinden birisidir. Kaizen Maliyetleme Sistemi 1970’li yıllarda geliştirilmiş olup, halen en önemli Japon işletmeleri tarafından kullanılmaktadır. Bir mamule üretim sürecinde uygulanan Kaizen Maliyetleme Sisteminin iki temel amacı bulunmaktadır. Bu amaçlardan birincisi Kaizen Felsefesini üretim sürecine uygulayarak maliyet azaltımını sağlamaktır. Ulaşılması istenen amaçlardan ikincisi ise değer katma...

  13. Résistance culturelle et “Révolution nationale” pétainiste: Les Mouches de Jean-Paul Sartre comme dénonciation d’une religion aliénante sous la France de Vichy

    Directory of Open Access Journals (Sweden)

    Nathalie Stevens

    2009-12-01

    Full Text Available Este artículo analiza de qué manera Jean-Paul Sartre utilizó el teatro –y notablemente su primera obra Les Mouches- para criticar el régimen de Vichy y su instrumentalización de las creencias religiosas a fin de someter y dominar a la población francesa. Él no sólo quiso ilustrar la conveniente relación entre la Iglesia y el poder sino también mostrar las posibilidades con que contaban los intelectuales franceses para luchar contra la dominación de Vichy, la censura y las represalias de los adversarios políticos.___________________ABSTRACT:This paper analyses the way in which Jean-Paul Sartre used the theatre – and outstandingly, his first play Les Mouches - to criticise the regime of Vichy and the way it exploited religious beliefs in order to subjugate and dominate the French population. Not only did he manage to illustrate the convenient relationship between the Church and the power, but also showed how the French intellectuals were able to fight against the domination of Vichy, the censorship and the reprisals against political adversaries.

  14. deSiertoS de aliMentoS. aProXiMaCioneS ConCePtUaleS al eStUdio JURÍDICO DEL PROBLEMA DEL HAMBRE

    Directory of Open Access Journals (Sweden)

    Cesar Augusto Molina Saldarriaga

    2014-12-01

    Full Text Available La protección del Derecho a la Alimentación en el contexto colombiano no ha sido clara. La naturaleza del derecho y sus ámbitos de protección obligan a estudiar estrategias que superen las visiones unidimensionales de la disciplina jurídica en su reconocimiento, protección y garantía. Los estudios sobre el fenómeno alimentario han dado lugar al surgimiento del concepto Desiertos de Alimentos. Este ofrece puntos de reflexión importantes en relación con el Derecho a la Alimentación; sin embargo, en Colombia los estudios desde él son inexistentes. A partir de un levantamiento del estado del arte sobre Desiertos de Alimentos se analiza su relación con el Derecho a laAlimentación, con el objeto de determinar la importancia de los es- tudios y estrategias de atención holísticos e interdisciplinares desde el derecho para atender las problemáticas alimentarias. Se concluye que los fenómenos alimentarios son complejos, requieren aproximaciones multidimensionales y la transformación de la cultura jurídica para atenderlos.

  15. Advancing Glaciological Applications of Remote Sensing with EO-1: (1) Mapping Snow Grain Size and Albedo on the Greenland Ice Sheet Using an Imaging Spectrometer, and (2) ALI Evaluation for Subtle Surface Topographic Mapping via Shape-from Shading

    Science.gov (United States)

    2003-01-01

    The Hyperion sensor, onboard NASA's Earth Observing-1 (EO-1) satellite,is an imaging spectroradiometer with 220 spectral bands over the spectral range from 0.4 - 2.5 microns. Over the course of summer 2001, the instrument acquired numerous images over the Greenland ice sheet. Our main motivation is to develop an accurate and robust approach for measuring the broadband albedo of snow from satellites. Satellite-derived estimates of broadband have typically been plagued with three problems: errors resulting from inaccurate atmospheric correction, particularly in the visible wavelengths from the conversion of reflectance to albedo (accounting for snow BRDE); and errors resulting from regression-based approaches used to convert narrowband albedo to broadband albedo. A typerspectral method has been developed that substantially reduces these three main sources of error and produces highly accurate estimates of snow albedo. This technique uses hyperspectral data from 0.98 - 1.06 microns, spanning a spectral absorption feature centered at 1.03 microns. A key aspect of this work is that this spectral range is within an atmospheric transmission window and reflectances are largely unaffected by atmospheric aerosols, water vapor, or ozone. In this investigation, we make broadband albedo measurements at four sites on the Greenland ice sheet: Summit, a high altitude station in central Greenland; the ETH/CU camp, a camp on the equilibrium line in western Greenland; Crawford Point, a site located between Summit and the ETH/CU camp; and Tunu, a site located in northeastern Greenland at 2000 m. altitude. Each of these sites has an automated weather station (AWS) that continually measures broadband albedo thereby providing validation data.

  16. Etablissement de scénarios alternatifs de valorisations alimentaires et non alimentaires des ressources céréalières wallonnes à l'horizon 2030

    Directory of Open Access Journals (Sweden)

    Van Stappen, F.

    2014-01-01

    Full Text Available Alternative scenarios for food and non-food uses of Walloon cereals by 2030. Topic. Based on the current uses of cereals grown in Wallonia (Belgium, various scenarios defining possible futures for the Walloon cereal sector have been created. Purpose. These scenarios lay the basis for research aiming at assessing the sustainability of food and non-food uses of cereals. Method. Based on contrasted hypotheses, four scenarios for the uses of Walloon cereals by 2030 have been defined with the support of stakeholders involved in all the steps of the chain. Results. The first scenario, called "Business-as-Usual", extrapolates trends from 15 years before 2010 and up to 2030. In the second scenario, called "Strategic", the current system is optimized from the environmental, economic and social point of view. The third and fourth scenarios break with current trends. The third scenario, called "Localization", considers an increased autonomy and the development of new cereal processing units in Wallonia. The fourth scenario, called "Globalization", focuses on a massive level of cereal export in response to an increasing demand from the global market and deals with high added-value products within Wallonia. Conclusions. Issues such as competition between food uses and non-food uses of cereals and of Walloon dependency on imports are addressed in these scenarios illustrating possible future situations, from food self-sufficiency to dramatic globalization, through the development of new outlets combining the adaptation of cropping practices, consumption, the evolution of habits and the use of new technologies.

  17. 从阿里平台看农产品电子商务发展趋势%The Development Trend of Agricultural Products E-business from the Perspective of Ali Platform

    Institute of Scientific and Technical Information of China (English)

    陈亮

    2015-01-01

    当前,电子商务发展呈现无线化、全球化、娱乐化、线上线下一体化、农村发力、大数据作用凸显等趋势。农产品电子商务发展也出现如下几个新特点:一是通过互联网用心做农业的“新农人”崛起;二是原产地农产品直销成为热点;三是越来越多的海外农产品涌进中国;四是生鲜农产品电子商务快速发展;五是非标准化农产品探索新标准;六是农产品成为县域电子商务的关键抓手,一些特点明显的县域电子商务模式不断涌现。%At present,the development of e-business is demonstrating the characteristics of wireless,global,entertaining, online and offline integrated,the rising force in rural areas,and the highlighted big data. And some new features of e-business of agricultural products existed:first,the rising of“new farmers”who doing agriculture related business through internet;second, the hot direct sell of agricultural products from areas of origin;third,more and more imported agricultural products;fourth,the rapid developing e-business of fresh agricultural products;fifth,exploring new standard for non standard agricultural products;and sixth,agricultural products as the focus of e-business in county areas.

  18. Diversifier les rotations céréalières notamment avec du pois et du colza – Données récentes d’expérimentations et d’études

    Directory of Open Access Journals (Sweden)

    Schneider Anne

    2010-09-01

    Full Text Available Simplification has been a clear trend in the composition of French crop rotations in the past decades, whereas agronomic knowledge proves the interest of diversification in order to benefit from the so called “preceding effects” and “cumulative effects”. It is needed to study the possible input of crops such as rape seed or pea for the cereal-based rotations in agronomic terms but also in economic and environmental terms. The first step is to quantify the impacts specifically due to the change in crop succession composition, and afterwards to allocate an objective economic value to them so that they are easy to integrate into comparisons of production systems. The regional case studies of a current multi-partner project enable to illustrate the economic and environmental evaluation of alternatives to the rotation “Oilseed rape – Wheat – Barley”. In addition, the recent field experiment data of this project (farm tests or experimental trials provide technical and scientific elements on technical feasibility and the economic performance of the innovative succession “pea before rape seed”, but also on the interest of the introduction of symbiotically fixed nitrogen in crop rotations in order to decrease the negative environmental impacts of mineral fertilisers-based systems. Diversification of crops and nitrogen fixation appear to be two key elements for (i competitiveness, when at least the agronomic effects are taken into account, and (ii sustainable systems, when one considers the preservation of farm potential and of the environment.

  19. Ekphrasis : au lieu de décrire ce qu’ils voyaient, ils réalisèrent ce qui était décrit

    Directory of Open Access Journals (Sweden)

    Ana Vanessa Lucena

    2014-04-01

    Full Text Available Cette contribution s’insère dans le domaine des recherches actuelles en didactique des arts visuels mettant en évidence les pratiques de la réception des œuvres. Elle rend compte d’un projet d’apprentissage artistique prenant comme matière la collection René et Madeleine Junod et pratiquée durant quatre mois de leçons hebdomadaires dans deux classes de 7e maturité d’une école publique de la ville de La Chaux-de-Fonds en Suisse. Le projet a été vécu en trois parties : un exercice d’ekphrasis et de reproduction par la méthode de la grille de copie en salle de classe, une série de « jeux de stimulation de l’observation » pendant une visite au musée, complétée par les activités de dessin et coloriage à la maison et en salle de classe. Cet article est centré sur le premier exercice de « l’ekphrasis » où il a été proposé aux élèves la description de quatre tableaux de styles, thèmes et artistes différents. Chaque descriptif posait des contraintes en termes de composition des images et d’interprétation d’un vocabulaire spécifique aux arts visuels. Ekphrasis: Instead of describing what they were seeing, they created what was described This contribution goes into the domain of current research in Visual Arts didactics putting in evidence the methods of the “réception d’œuvre”. It reports an artistic learning project based on René and Madeleine Junod’s collection and practiced during four month of weekly Visual Arts lessons in two 7th grade classes of a public school in the city of La Chaux-de-Fonds, Switzerland. The project was built in three parts: an “ekphrasis” activity, which implies describing by words a few paintings of the collection, then copying them using the “grille de copie” method; a few “games of observation skills stimulation” during the visit of a museum, then reinforced and completed by the “painting and drawing activities” at home and in the classroom. This article focuses only on the first exercise of the “ekphrasis” in which four paintings descriptions, all of different styles, themes and artists, were given to the students. Each description setting represented a constraint in terms of images composition and interpretation of a specific Visual Arts vocabulary.

  20. Rändeandmete kvaliteet ja rändesuundumused Eestis aastatel 2000-2005 = The quality of migration data and the trends of migration in Estonia in 2000-2005 / Alis Tammur, Tiit Tammaru, Ene- Margit Tiit

    Index Scriptorium Estoniae

    Tammur, Alis

    2006-01-01

    Eesti statistilise rahvastikuarvestuse alus on olnud viimase rahvaloenduse rahvaarv, millele lisatakse omavalitsusüksuste kaupa registripõhiselt kogutavad sünnid, surmad ning sisse- ja väljaränne. Rahvaloenduse ja rahvastikuregistri andmete põhimõtteline erinevus. Sise- ja välisrände arvestamise probleemid, rändesuundumuste analüüs. Diagramm. Tabelid

  1. Exploitation du consommateur et aliénation du client. La sphère domestique comme espace de création de valeur économique et symbolique

    Directory of Open Access Journals (Sweden)

    Alexandra Perronet

    2006-07-01

    Full Text Available La phase actuelle d’accumulation capitalistique tend à faire de la consommation non seulement une sphère de reproduction des rapports sociaux, mais un lieu de production des forces de travail. Partant de ce postulat, cet article se propose de montrer comment les pratiques de consommation structurent les rapports sociaux de production. Selon l’auteur, il s’agit d’une question à la fois pratique et symbolique : la consommation détermine tant l’organisation des rapports sociaux que le développement d’un imaginaire social.

  2. Exploitation du consommateur et aliénation du client: la sphère domestique comme espace de création de valeur économique et symbolique

    Directory of Open Access Journals (Sweden)

    Perronet, Alexandra

    2006-07-01

    Full Text Available La phase actuelle d’accumulation capitalistique tend à faire de la consommation non seulement une sphère de reproduction des rapports sociaux, mais un lieu de production des forces de travail. Partant de ce postulat, cet article se propose de montrer comment les pratiques de consommation structurent les rapports sociaux de production. Selon l’auteur, il s'agit d'une question à la fois pratique et symbolique : la consommation déterminant tant l'organisation des rapports sociaux que le développement d'un imaginaire social.

  3. Exploitation du consommateur et aliénation du client. La sphère domestique comme espace de création de valeur économique et symbolique

    OpenAIRE

    Perronet, Alexandra

    2006-01-01

    La phase actuelle d’accumulation capitalistique tend à faire de la consommation non seulement une sphère de reproduction des rapports sociaux, mais un lieu de production des forces de travail. Partant de ce postulat, cet article se propose de montrer comment les pratiques de consommation structurent les rapports sociaux de production. Selon l’auteur, il s'agit d'une question à la fois pratique et symbolique : la consommation déterminant tant l'organisation des rapports sociaux que le développ...

  4. Etude d'un revêtement d'acier inoxydable Z 2 CND 18-12 réalisé sur un acier doux, sous irradiation laser avec injection de poudre coaxiale au faisceau

    OpenAIRE

    Fouquet, F.; Sallamand, P.; Dierickx, P.; Bonne, D.; Millet, J

    1994-01-01

    Le présent travail traite du dépôt d'acier inoxydable austénitique de type AISI 316 L sur acier doux par projection de poudre sous faisceau laser et de la caractérisation du revêtement élaboré. Les revêtements obtenus par cette technique sont de bonne qualité, exempts de fissures, avec peu de porosités et parfaitement adhérents au substrat. Leur microstructure très fine est dendritique ou cellulaire. La structure est apparue majoritairement austénitique, mais avec présence non négligeable de ...

  5. 深孔钻探降低钻探成本方法%AnAlySiS of method reduCinG CoSt of deep-hole drillinG CoSt

    Institute of Scientific and Technical Information of China (English)

    王幼凤

    2015-01-01

    Combined with practice of deep-hole drilling in recent years, this paper analyzed the composition of the drilling cost, discussed the influence factors and put forward a way of reducing the cost.%结合近年来施工的深部钻探实践,从深部钻探成本构成分析入手,讨论了影响钻探成本的因素,提出了降低钻探成本的途径。

  6. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... Aly. Today, Aly is still focused on a quality life. Aly Becker Aly is still the go-getter ... you or a loved one? Click here . A Quality Life: Episode 10, Marion’s Palliative Care Story January, 2016 ...

  7. Therapeutic Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Models of Pulmonary and Extrapulmonary Acute Lung Injury.

    Science.gov (United States)

    Liu, Ling; He, Hongli; Liu, Airan; Xu, Jingyuan; Han, Jibin; Chen, Qihong; Hu, Shuling; Xu, Xiuping; Huang, Yingzi; Guo, Fengmei; Yang, Yi; Qiu, Haibo

    2015-01-01

    Bone marrow-derived mesenchymal stem cells (MSCs) offer a promising therapy for acute lung injury (ALI). However, whether the same MSC treatments possess similar potential for different ALI models is not fully clear. The present study evaluated the distribution and therapeutic effects of intravenous MSC administration for the treatment of intratracheal lipopolysaccharide (LPS)-induced intrapulmonary ALI and intravenous LPS/zymosan-induced extrapulmonary ALI, matched with lung injury severity, at 30 min and 1, 3, and 7 days. We found that MSC transplantation attenuated lung injury and inhibited lung inflammation in both ALI models. The benefits of MSCs were more significant in the intrapulmonary ALI mice. In vivo and ex vivo fluorescence imaging showed that MSCs primarily homed into the lung. However, more MSCs were recruited into the lungs of the intrapulmonary ALI mice than those of the extrapulmonary ALI mice over the time course. A few MSCs were also detected in the liver and spleen at days 3 and 7. In addition, the two ALI models showed different extrapulmonary organ dysfunction. A lower percentage of cell apoptosis and SDF-1α levels was found in the liver and spleen of the intrapulmonary ALI mice than in those of the extrapulmonary ALI mice. These results suggested that the two ALI models were accompanied with different degrees of extrapulmonary organ damage, which resulted in differences in the trafficking and accumulation of MSCs to the injured lung and consequently accounted for different therapeutic effects of MSCs for lung repair in the two ALI models. These data suggest that intravenous administration of MSCs has a greater potential for the treatment of intrapulmonary ALI than extrapulmonary ALI matched with lung injury severity; these differences were due to more recruitment of MSCs in the lungs of intrapulmonary ALI mice than those of extrapulmonary ALI mice. This finding may contribute to the clinical use of MSCs for the treatment of ALI. PMID

  8. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... her goal is simple: to live the best life possible. This is her palliative care story. Aly ... blood. Determined to live an active and normal life, Aly kept up with all of her classes, ...

  9. 77 FR 14596 - Supplemental Identification Information for Thirteen Individuals and One Entity Designated...

    Science.gov (United States)

    2012-03-12

    .... nationals or the national security, foreign policy, or economy of the United States; (3) persons determined....k.a. JUMALE, Ahmed Ali; a.k.a. JUMALI, Ahmed Ali), P.O. Box 3312, Dubai, United Arab...

  10. Differential effects of kidney-lung cross-talk during acute kidney injury and bacterial pneumonia

    OpenAIRE

    Singbartl, Kai; Bishop, Jeffery; Wen, Xiaoyan; Murugan, Raghavan; Chandra, Saurabh; Filippi, Marie-Dominique; John A Kellum

    2011-01-01

    Acute kidney injury (AKI) and acute lung injury (ALI) represent serious, complex clinical problems. The combination of AKI and ALI drastically decreases survival. However, detailed knowledge about the interactions between these two organs is scarce.

  11. The value of nitrogen washout/washin method in assessing alveolar recruitment volume in acute lung injury patients

    Institute of Scientific and Technical Information of China (English)

    李洋

    2013-01-01

    Objective To evaluate the precision and feasibility of nitrogen washout/washin method in assessing lung recruitment of acute lung injury(ALI)patients.Methods Fifteen ALI patients underwent mechanical ventilation

  12. Developing novel therapeutic strategies for acute lung injury and infection-peripheral blood monocyte depletion and prophylactic antimicrobial therapy

    OpenAIRE

    Dhaliwal, Kanwaldeep

    2013-01-01

    BACKGROUND Acute lung injury (ALI) and nosocomial pneumonia are major causes of morbidity and mortality. There are 200,000 cases per year of ALI in the US with a mortality of 40%. On the intensive care unit (ICU), ALI accounts for over 40% of all ventilated patients at any one time. Despite this huge burden on healthcare and the relatively high prevalence, no therapies currently exist in clinical practice that attenuate the condition. The pathophysiology and aetiology of ALI is...

  13. Ulster Medical Society Junior Members Forum Thursday 12th December 2013

    OpenAIRE

    Boyle, AJ; Digangi, A; Mottram, LJ; Hamid, U; McNamee, L; G. White; Cross, LJM; McNamee, J; O'Kane, C; McAuley, DM; Kennedy, F.; Russell, A; Smithson, WH; Parsons, L.; Robertson, I.

    2016-01-01

    Introduction Platelet activation has a role in the pathogenesis of acute lung injury (ALI). Observational data suggests aspirin treatment may prevent the development of ALI in critically ill patients. However, it is unknown if aspirin usage alters outcomes in patients with established ALI. Methods All patients with ALI were identified prospectively in a single large regional medical and surgical Intensive Care Unit (ICU) between December 2010 and July 2012. Demographic, clinical, and laborato...

  14. Neutrophil Elastase Contributes to Acute Lung Injury Induced by Bilateral Nephrectomy

    OpenAIRE

    Ishii, Tomoko; DOI, Kent; Okamoto, Koji; Imamura, Mitsuru; Dohi, Makoto; Yamamoto, Kazuhiko; Fujita, Toshiro; Noiri, Eisei

    2010-01-01

    Acute kidney injury (AKI) is a serious problem in critically ill patients of intensive care units. It has been reported previously that AKI can induce acute lung injury (ALI), as well as cause injuries to other remote organs, including the lungs. Patients with AKI complicated by ALI show remarkably high mortality. ALI is characterized by neutrophil infiltration into the lung. Neutrophil elastase (NE) is a key enzyme for tissue injury caused by activated neutrophils, such as occurs in ALI. The...

  15. Soluble Endothelial Selectin in Acute Lung Injury Complicated by Severe Pneumonia

    Directory of Open Access Journals (Sweden)

    Daisuke Osaka, Yoko Shibata, Kazunori Kanouchi, Michiko Nishiwaki, Tomomi Kimura, Hiroyuki Kishi, Shuichi Abe, Sumito Inoue, Yoshikane Tokairin, Akira Igarashi, Keiko Yamauchi, Yasuko Aida, Takako Nemoto, Keiko Nunomiya, Koji Fukuzaki, Isao Kubota

    2011-01-01

    Full Text Available Background: Pneumonia is still one of the most frequent causes of death in the elderly. Complication of acute lung injury (ALI/acute respiratory distress syndrome (ARDS by pneumonia makes patients very ill due to severe respiratory failure. Biomarkers that can discriminate the presence of complicating ALI/ARDS are required for early detection. The aim of this research was to investigate whether soluble endothelial selectin (sES could be a biomarker for ALI.Methods: Serum sES levels were measured in 27 pneumonia patients, who were enrolled between April 2006 and September 2007. Among these patients, six had ALI or a condition that was clinically comparable to ALI (cALI. All patients who were enrolled were successfully treated and survived.Results: Circulating sES levels were elevated in pneumonia patients with ALI/cALI, and sES levels decreased following treatment of their pneumonia. Univariate and multivariate logistic regression analyses showed that sES was the only significant factor for identifying complicating ALI/cALI, independently of C-reactive protein (CRP and lactate dehydrogenase (LDH. By receiver operating characteristic (ROC curve analysis, the cut-off value for sES was 40.1 ng/mL, with a sensitivity of 0.8 and a specificity of 0.8.Conclusion: sES may be a useful biomarker for discriminating complicating ALI/cALI in patients with severe pneumonia.

  16. Ascertainment of acute liver injury in two European primary care databases

    NARCIS (Netherlands)

    Ruigómez, A.; Brauer, R.; Rodríguez, L. A García; Huerta, C.; Requena, G.; Gil, M.; de Abajo, Francisco; Downey, G.; Bate, A.; Tepie, M. Feudjo; de Groot, M.C.H.; Schlienger, R.; Reynolds, R.; Klungel, O.

    2014-01-01

    Purpose The purpose of this study was to ascertain acute liver injury (ALI) in primary care databases using different computer algorithms. The aim of this investigation was to study and compare the incidence of ALI in different primary care databases and using different definitions of ALI. Methods T

  17. Ali vadba na ravnotežni plošči Wii z igrami Wii Fit pri bolnikih s pridobljenimi okvarami perifernih živcev vpliva na ravnotežje in hojo?: Does training on the Wii balance board with Wii Fit games have an effect on balance and walking in patients with acquired peripheral nerve lesions?:

    OpenAIRE

    Vidmar, Gaj; Zupanc, Aleksander

    2014-01-01

    Background: Patients with acquired peripheral lesions have balance and walking disorders. The aim of our study was to determine if training on the Wii balance board with Wii Fit games improves balance and walking in patients with acquired peripheral nerve lesions. Methods: Our observational study involved 11 patients (6 male, 5 female), aged 43.5 years on average (range 15-72 years). They performed training on the Wii balance board in addition to physiotherapy every day for 30 min per session...

  18. Analysis on Financing Cases of Internet Financial Boost of Small and Micro Businesses:Taking Ali as an Example%互联网金融助推小微企业融资的案列分析--以阿里金融为例

    Institute of Scientific and Technical Information of China (English)

    郑兴东; 王明虎; 徐美丽

    2015-01-01

    with the rapid development of mobile payment, social networks, big data and cloud computing such as Internet information technology, mass consumption patterns change and innovation of modern financial theories, Internet and financial deepening mutual integration and penetration. Small and micro businesses and made great contribution to the economic development, but the problem of financing Small and micro businesses have also been there. Research on small micro enterprise financing problems theorists have been in progress, but because of the national economic structure and the limitations of existing policies, small micro enterprise financing problems have not been fundamentally resolved always. Internet finance makes completely solve the small micro enterprise financing problems become possible. Internet Finance six major models as well as the advantages of the Internet financial data of low cost advantage, and the small micro enterprise financing difficulties and the existing analysis methods are put forward to solve the theory, finally by analyzing the example of Alibaba small micro finance.%伴随移动支付、社交网络、大数据和云计算等互联网信息技术的飞速发展,大众消费方式的改变以及现代金融理念的革新,互联网与金融业的相互融合和渗透日益深化。小微企业对于经济的发展做出了巨大的贡献,但是小微企业的融资问题却也一直存在。理论界针对小微企业融资问题的研究一直在进行,但是由于国家经济结构与现有政策的限制,小微企业融资问题一直没有得到根本的解决。互联网金融的产生,使得彻底解决小微企业融资问题成为了可能。互联网金融有六大模式并具有大数据优势与低成本优势,对小微企业存在融资困境进行理论分析能够得到相应的解决方法,阿里巴巴公司就是很好的实例。

  19. L’élevage des abeilles mélipones sur l’île de Cuba : une enquête ethnozoologique réalisée dans la plaine du río Mayabeque et la forêt de la Sierra del Rosario

    OpenAIRE

    Rouzic, Samuel Perichon Le; Peña, Walberto Lóriga; Lorenzo, Jorge Demedio

    2015-01-01

    En Amérique centrale, l’élevage des abeilles sans dard est une pratique vieille d’au moins deux millénaires, qui a connu son apogée à la fin de l’ère maya. Les Méliponinés, sous-famille à laquelle appartiennent ces abeilles, rassemblent près de 500 espèces distribuées pour l’essentiel en zone intertropicale. La plupart d’entre elles nichent dans des cavités d’arbres secs ou sous terre, et affectionnent les forêts ombrophiles où elles assurent un rôle actif dans la pollinisation des plantes sa...

  20. Translation into Turkish of: “Changes to publication requirements made at the XVIII International Botanical Congress in Melbourne – what does e-publication mean for you?”. Translated by Ali A. Dönmez, Yusuf Menemen and Zübeyde Uğurlu

    Directory of Open Access Journals (Sweden)

    Sandra Knapp

    2012-03-01

    Full Text Available Changes to the International Code of Botanical Nomenclature are decided on every 6 years at Nomenclature Sections associated with International Botanical Congresses (IBC. The XVIII IBC was held in Melbourne, Australia; the Nomenclature Section met on 18-22 July 2011 and its decisions were accepted by the Congress at its plenary session on 30 July. Several important changes were made to the Code as a result of this meeting that will affect publication of new names. Two of these changes will come into effect on 1 January 2012, some months before the Melbourne Code is published. Electronic material published online in Portable Document Format (PDF with an International Standard Serial Number (ISSN or an International Standard Book Number (ISBN will constitute effective publication, and the requirement for a Latin description or diagnosis for names of new taxa will be changed to a requirement for a description or diagnosis in either Latin or English. In addition, effective from 1 January 2013, new names of organisms treated as fungi must, in order to be validly published, include in the protologue (everything associated with a name at its valid publication the citation of an identifier issued by a recognized repository (such as MycoBank. Draft text of the new articles dealing with electronic publication is provided and best practice is outlined.To encourage dissemination of the changes made to the International Code of Nomenclature for algae, fungi, and plants, this article will be published in BMC Evolutionary Biology, Botanical Journal of the Linnean Society, Brittonia, Cladistics, MycoKeys, Mycotaxon, New Phytologist, North American Fungi, Novon, Opuscula Philolichenum, PhytoKeys, Phytoneuron, Phytotaxa, Plant Diversity and Resources, Systematic Botany and Taxon.

  1. Analysis on the Scenery Characteristic and the Influence Element of the Tularemia Natural Focus in Ali,Tibet%西藏阿里野兔热自然疫源地景观特征和影响因素分析

    Institute of Scientific and Technical Information of China (English)

    党荣理; 周新荣; 王天祥; 张桂林; 吉宝新; 窦君

    2000-01-01

    本文分析了西藏阿里野兔热自然疫源地景观特征和影响因素,着重探讨了自然疫源地存在的客观条件及其与自然疫源性疾病的内在关系,为该地区野兔热自然疫源地的深入研究和防治提供参考.

  2. QUALICOPC: Birinci basamak sağlik hizmetlerini kalite, maliyet ve aşitlik açisindan değerlendiren çok ülkeli bir çalişma* = QUALICOPC: a multi-country study evaluating quality, costs and equity in primary care.

    NARCIS (Netherlands)

    Akman, M.; Kalaça, S.; Sargin, M.; Tuncel, B.; Ünlüoğlu, I.; Uğurlu, M.; Schäfer, W.L.A.; Boerma, W.G.W.; Groenewegen, P.P.

    2012-01-01

    Objectives: The QUALICOPC (Quality and Costs of Primary Care in Europe) study aims to evaluate the performance of primary care systems in Europe in terms of quality, equity and costs. QUALICOPC is funded by the European Commission under the "Seventh Framework Program". In this article the backgroun

  3. La lixiviation d’azote nitrique dans les rotations céréalières avec colza : un diagnostic à partir de l’analyse de résultats d’expérimentations pluriannuelles et de modélisations

    Directory of Open Access Journals (Sweden)

    Reau Raymond

    2006-11-01

    Full Text Available Nitrate leaching was measured during 6 years in a crop rotation including oilseed rape (OSR and winter wheat in two field trials, on two rendzina soils differing by their water content, in Le Magneraud (West of France and Martincourt (East of France. Results show that nitrate losses are variable within the year and drainage: between 20 and 95 kgN.ha–1.an–1. When the soil remains without cover crop after OSR, losses under wheat following OSR are definitely higher than under OSR following wheat: respectively 54.1 kgN.ha–1.an–1 and 14.8 kgN.ha–1.an–1 during the first three years in Le Magneraud. Results even show that nitrate losses differed according to N strategy management. Among the treatments of nitrogen management, the least losses are observed with optimized fertilization plus OSR volunteers used as cover crop between OSR and wheat; and the highest losses are observed with high fertilization without OSR volunteers as catch crop : respectively in Le Magneraud (second phases of three years 29.9 and 61.1 kgN.ha–1.an–1, and at Martincourt 43.0 and 61.4 kgN.ha–1.an–1 on average. Simulations realized with LIXIM and DEAC models for new years, soils and regions, show the same trend that experimental results: nitrate losses are higher under wheat after OSR, and the high performance cropping systems are based on optimized N fertilization management of OSR and the catch of nitrate at the end of summer by OSR (after wheat or its volunteers (before wheat.

  4. Çokanlamlilik Ve Değiştirim Üzerine Anlambilimsel Bir Çalişma: Fransizcada Algilama Eylemleri Une Etude Sémantique Sur La Polysémie Et La Commutation : Le Cas Des Verbes De Perception En Français

    Directory of Open Access Journals (Sweden)

    Fulya BOYRAZ

    2013-09-01

    Full Text Available Dans ce travail, nous avons distingué l’expression linguistique dela perception d’une phénoménologie de la perception et nous n’avonsétudié que les “verbes de perception”. Il faut noter justement ici que lesverbes dont le contenu sémantique désigne le perceptible (comme puer,luire… sont très différents des verbes qui imposent l’achèvement de laperception (voir, entendre… et des verbes dont la signification impliqueune intention précise (regarder, toucher, écouter…. Dans ce cadre, cespremiers sont écartés de cette étude. Cet article vise à aborder lesproblèmes engendrés par la polysémie et la commutation. Nous avonssuivi une démarche sémantique et discursive en vue d’observer lesacceptions de ces verbes et d’exposer les sous-catégories en tenantcompte de la richesse d’expression que fournissent ces verbes.Il est possible de définir la commutation comme fait desubstitutiond’un mot par un autre lorsqu’ils sont polysémiques ou lorsqu’ilsrenvoient à la même zone de signification. Bien que les verbes deperception en français soient polysémiques, il n’est pas difficile derelever le sens discursif en tenant compte du contexte et lacommutation peut se faire selon les possibilités du contexte. Toutefois,il y a des cas où ces verbes sont employés pour désigner plutôt lerésultat d’une activité intellectuelle et ils recouvrent dans ce cadre, lasignification du verbe “comprendre”. Le fait qui ne permet pas tojoursune commutation entre ces verbes et qui pose certains problèmesdidactiques, surtout pour expliquer le sens linguistique et la valeurdiscursive dans l’enseignement du français langue étrangère. Bu çalışmada, algılamanın dilsel ifadesi olan sözcükler, bir olgu olan “algı”dan ayrılmış ve sadece sözcük türü olarak “algılama eylemleri” araştırma konusu yapılmıştır. Anlamsal içeriği, kokmak, parıldamak, çatırdamak gibi algılananın algıya neden olan özelliklerini ifade eden eylemlerin, algılama eyleminin gerçekleşimini ifade eden eylemlerden (görmek, duymak gibi ve algılamaya yöneltilen bilinçli eylemlerden (bakmak, dinlemek, dokunmak gibi ayrı tutulması gerekir. Bu çalışmada, yukarıda sözü edilen eylemlerden ilk grubu oluşturanlar inceleme dışında tutulmuş ve algıya yönelik bilinçli ve istemli algı ifade den eylemlerle, bu eylemlerin bir sonucu olarak ortya çıkan algılama ya da algılayamama durumunu ifade eden eylemler söz konusu edilmiştir. Çalışmamızda Fransızca’daki algılama eylemleri, özellikle çokanlamlı yapıları nedeniyle ortaya koydukları sorunlar çerçevesinde anlambilimsel açıdan ve söylemsel boyuttaki ifade zenginlikleri nedeniyle söylemsel açıdan ele alınmıştır.Değiştirim anlamdaş ya da yakın anlamlı sözcükler arasında birbirinin yerine geçme durumu olarak tanımlanabilir ve değiştirim yapılabilmesi için sözcede (énoncé ya da tümcede (phrase anlamsal ve söylemsel değerin korunması ön koşuldur. Fransızcanın algılama eylemleri (toucher, regarder, voir, écouter, entendre, sentir çokanlamlı yapıya sahip olmalarına rağmen söylem içerisinde ve bağlam değerlendirildiğinde anlamları kesinleşmekte ve değişitirim (commutation söz konusu bağlamın izin verdiği ölçüde, gerçekleşebilmektedir. Oysa ki bu sözcükler duyusal algı değil de zihinsel algı sürecinin sonucu olan “anlamak” sözcüğünün yerine geçtikleri zaman dilsel ve söylemsel sorunlar ortaya çıkmakta, değişitirim seçenekleri daralmakta ve özellikle Fransızcanın yabancı dil olarak öğretiminde söylemsel değeri açıklamak daha zor hale gelmektedir.

  5. Ocena učinkovitosti, varnosti in sprejemljivosti orodisperzibilnega risperidona pri bolnikih s shizofrenijo ali bipolarno manijo in pri vedenjskih motnjah dementnih bolnikov: Evaluation of efficacy, safety and acceptability of orodispersible risperidone in patients with schizophrenia, bipolar mania and behavioural disturbances in dementia patients:

    OpenAIRE

    Barbič-Žagar, Breda; Dular Meglič, Tina; Ristovski, Aleksandar

    2008-01-01

    Second generation antipsvchotics are currently the drugs of choice for the treatment of schizophrenia and bipolar mania, as well as for behavioural symptoms in patients with dementia. All these diseases represent an important healthcare problem in Europe, so that early treatment is recommended. Due to improved patient compliance, new pharmaceutical forms of already proven therapy are developed. Orally disintegrated tablets disintegrate rapidly in the mouth without water. Therefore, a study wa...

  6. La pyramide de Archie B. Carroll a l’épreuve du jeu des acteurs francophones – Quelles sont les parties prenantes et quelles sont leurs différentes représentations en matière de Responsabilité Sociale des Entreprises ? Inventaire Internet réalisé en 2008 sur 313 sites francophones

    OpenAIRE

    Christian Bourion; Sybil Persson

    2008-01-01

    Afin d’actualiser la connaissance des débats susceptibles d’impacter la régulation opérée sous l’égide de la Responsabilité Sociale des Entreprises, l’étude établit un bilan 2008 des Parties prenantes francophones en présence. Après avoir rappelé le modèle de Carroll qui établit une hiérarchie des différentes représentations en matière de Corporate Social Responsability, la recherche explore la toile internet pour retenir 313 sites qui permettent d’identifier et de catégoriser les acteurs en ...

  7. Analyse Conseptuelle Et Perceptice Du Traitement Littéraire De L’aliénatiın Dans “La Nausée “ De Jean Paul Sartre Analysis Of Conceptual And Perceptual Processing Of Literary Of Alienation In Nausea By Jean-Paul Sartre

    Directory of Open Access Journals (Sweden)

    Muzaffer KAYA

    2013-03-01

    Full Text Available In this work where a phlosophical thought is told and explained,Jean Paul Sartre states his phlosophic views by means of protagonistRoquentin. Roquentin lives in a world that is not understood by himand he, bevilderedly, observes how the urban bourgeoisie cant perceivethe reflections of the reality.Taking care of his thoughts to be clear, Jean Paul Sartre used aplain tongue and paid attention to his style to be cognisable. This is the general characteristic of that period.Authors made a point of beingapparent intellectually in literary languageThe basic idea of the novel is that the hero of the work Roquentinis in a constant anxiety and demoralization. This is such a state ofdistress that led our hero to analyze the situation and try to understandthe process. He decides to define this anxiety,he felt, as nausea andrealizes that he does not recognize the status of this nausea.Accordingto him nausea is being revolted at everything and and a state ofalienation.Increasing state of nausea,in time, is an alienation from theobjects, the society,self-precense,women and finally the world.In this study we examined the sense of alienation in Jean PaulSartre’s Nausea under four sub-headings. Examining the personality ofthe Protagonist Rocquentin we probed that how he alienated from theobjects, the society, himself and the women and we came to aconclusion. In this context,we stated that alienation is one of the mostimportant social problems of our time and these problems causepsychic deterioration that arise through the confliction of the oldculturel values and the new habitudes. Cette oeuvre est un récit dans lequel se développe toute uneréflexion philosophique où Sartre montre son refus envers la société engénéral par le biais de Roquetin, qui vit dans un monde où il ne trouveaucun sens à la vie et où il s’étonne de voir que la bourgeoisie de la villene voit pas les aspects de la réalité qui, pour lui, sont assez évidents.Pour exprimer ses idées, Sartre utilise un langage sans ornementsrhétoriques qui peuvent rendre difficile sa compréhension, puisquesurtout, les auteurs engagés du XXème siècle (comme Sartre donnentplus d’importance au message qu’à la forme dans l’objectif d’être lu parle plus possible public.Le thème principal de l’oeuvre est le fait que Roquentin se trouvedans un état d’angoisse, un état de démoralisation ; une sorte d’ennuiqui va le mener à essayer de réfléchir sur ce qu’est l’existence ettrouver un moyen de l’expliquer. Il ressent une sorte d’angoisse qu’il vaappeler la nausée et il se rend compte qu’il ne peut définir l’existence decette nausée. Pour lui ce sentiment de nausée est comme une sorted’étrangeté et de dégout envers tout. Cette nausée qui progresse avec letemps se fait sentir en premier devant les objets puis devant personnesrencontrées et s’étend à tout son rapport au monde.

  8. Osmanlı Devleti’nde Kadınlara Yönelik Tarih Öğretimi Çabaları ve Ali Seydi Bey’in Kızlara Mahsûs Târîh-i Osmânî Adlı Eseri

    OpenAIRE

    2011-01-01

    ÖzetBu makalede Osmanlı Devleti’nde kadınlara yönelik tarih öğretimi paralelinde kaleme alınmış olan “Kızlara Mahsûs Târîh-i Osmânî” adlı eser, tarih eğitimi ve kadın eğitimi bağlamında incelenmiştir. Osmanlı Devleti’nde eğitim Tanzimat Fermanı’nın ilanından sonra değişmeye başlamıştır. Modernleşme paralelinde açılan yeni bürokratik kurumların nitelikli eleman ihtiyacını arttırması eğitimin devlet tarafından yeniden organize edilmesine ve yeni eğitim kurumlarının doğmasına yol açmıştır. Bu ye...

  9. WORD BORROWING AND VOCABULARY EXCHANGE IN TURKISH DIALECTS: CASE OF OSMANIYE TATAR DIALECT / TÜRK LEHÇELERI ARASINDA SÖZCÜK ALIS VERISI VE SÖZ VARLIĞI DEĞISIMI: OSMANIYE TATAR AĞZI ÖRNEĞI

    Directory of Open Access Journals (Sweden)

    Dr. Ercan ALKAYA

    2008-08-01

    Full Text Available The basic vocabulary which constructs the main vocabulary of alanguage is the word that is transferred from generation to generation in everylanguage, has importance of first degree and reflects important concepts aboutmankind and his environment. The words dealing with body, color, andconcepts about nature, animal names, numbers, and the most used verbs,words of holy concepts and persons and traditions consist of basic vocabularyof a language. In this study, the change in vocabulary of Kazan Tatar Turks, whomigrated from Kazan, Orenburg and Samara regions and inhabited in thevillage of Osmaniye of Çifteler, Eskisehir after 1884, was investigated. Thedialects of Tatar Turks who migrated from Kazan and its surrounding areawere affected by the local people who have been living in that region. Thoughthey still protect phonetical and morphological features of their language, itwas affected by the local dialect and Turkey Turkish.The main changes in the vocabulary of Tatar Turks in Osmaniye villagewere evaluated under several headings.

  10. « Le plus beau rêve réalisé » “ The most beautiful dream has come true ”: The ’Journal of Salonique’ and the Young Turks 1rst July 1908-30th June 1909

    Directory of Open Access Journals (Sweden)

    Joëlle Dalègre

    2012-05-01

    Full Text Available Le « Journal de Salonique », francophone et francophile, salue avec enthousiasme la Révolution Jeune-Turque à Salonique. Fidèle aux idéaux de la Révolution Française, il assure un soutien indéfectible aux Jeunes-Turcs en qui il place tous ses espoirs pour un nouvel Empire ottoman. Saadi et Samuel Levy en font un journal riche en informations à la fois sur la vie de Salonique et sur les nouveautés politiques. Il s’oppose également aux sionistes, jugeant que Salonique est, pour un Juif, le meilleur endroit de la terre et il invite les organisations juives à investir dans les tchifliks de Macédoine pour y établir les Juifs chassés d’Europe orientale par les pogroms.The “ Journal de Salonique ”, a French speaking and France loving newspaper, welcomes the revolution of the Young Turks on Thessaloniki with great enthusiasm. Faithful to the ideals of the French Revolution, it provided strong support to the Young Turks in which it places its hopes for a new Ottoman Empire. Saadi and Samuel Levy have given us a newspaper rich in information regarding the life of Thessaloniki and political novelty. It was opposed to the Zionists,maintaining the notion that Thessaloniki is the best place on earth for a Jew. So, the newspaper invited Jewish organizations to invest in tchifliks in Macedonia, in order to establish there the Jews who were expelled from eastern Europe by the pogroms.

  11. Breath-hold times in patients undergoing radiological examinations: comparison of expiration and inspiration with and without hyperventilation: primerjava časov po izdihu in po vdihu z ali brez hiperventilacije: Zadrževanje diha pri bolnikih, ki so radiološko preiskovani:

    OpenAIRE

    Groell, Reinhard; Schaffler, Gottfried J; Schloffer, Stephan

    2001-01-01

    Background: Breath-holding is necessary for imaging studies of the thorax and abdomen using computed tomography, magnetic resonance imaging or ultrasound examinations. The purpose of this study was to compare the breath-hold times in expiration and inspiration and to evaluate the effects of hyperventilation.Patients and methods. Thirty patients and 19 healthy volunteers participated in this study after informed consent was obtained in all. The breath-hold times were measured in expiration and...

  12. Scale Effects in Laboratory and Pilot-Plant Reactors for Trickle-Flow Processes Les conséquences de l'extrapolation appliquée aux procédés à écoulement ruisselant réalisés en laboratoire et dans les réacteurs des unités-pilotes

    Directory of Open Access Journals (Sweden)

    Sie S. T.

    2006-11-01

    Full Text Available Research and development studies in a laboratory are necessarily conducted on a scale which is orders of magnitude smaller than that in commercial practice. In the case of the development and commercialization of an unprecedented novel process technology, available laboratory results have to be translated into envisaged technology on a commercial scale, i. e. the problem is that of scaling-up. However, in many circumstances the commercial technology is more or less defined as far as type of reactor is concerned and laboratory studies are concerned with the generation of predictive information on the behaviour of new catalysts, alternative feedstocks, etc. , in such a reactor. In many cases the complexity of feed composition and reaction kinetics preclude the prediction to be made on the basis of a combination of fundamental kinetic data and computer models, so that there is no other option than to simulate the commercial reactor on a laboratory scale, i. e. the problem is that of scaling-down. From the point of view of R & D Defficiency, the scale of the laboratory experiments should be as small as possible without detracting from the meaningfulness of the results. In the present paper some problems in the scaling-down of a trickle-flow reactor as applied in hydrotreating processes to kinetically equivalent laboratory reactors of different sizes will be discussed. Two main aspects relating to inequalities in fluid dynamics resulting from the differences in scale will be treated in more detail, viz. deviations from ideal plug flow and non ideal wetting or irrigation of the catalyst particles. Although a laboratory reactor can never be a true small-scale replica of a commercial trickle-flow reactor in all respects, it can nevertheless be made to provide representative data as far as the catalytic conversion aspects are concerned. By ressorting to measures such as catalyst bed dilution with fine catalytically inert material it proves possible to carry out meaningful process research on hydrotreating processes on the scale of micro-reactors. Les études et mises au point effectuées en laboratoire sont nécessairement effectuées à plus petite échelle que les réalisations commerciales. Dans le cas de la mise au point et de la commercialisation de la technologie d'un procédé nouveau, il faudra traduire les résultats obtenus en laboratoire pour la technologie envisagée à l'échelle commerciale; le problème est donc l'extrapolation vers le haut. Cependant, bien souvent, la technologie commerciale, pour ce qui touche au type de réacteur, est plus ou moins bien définie et les études de laboratoire s'attachent à produire des données permettant de prévoir le comportement qu'auront dans ce réacteur des catalyseurs nouveaux, de matières premières de substitution, etc. Dans bien des cas, étant donné la complexité de la composition de la matière première et la cinétique de réaction, il est impossible de mener la prévision en s'appuyant sur les données cinétiques et les modèles informatiques, de sorte qu'il n'y a pas d'autre solution que la simulation du réacteur commercial à l'échelle du laboratoire; le problème est donc l'extrapolation vers le bas. Du point de vue de l'efficacité des études de recherche et développement, pour les expériences en laboratoire, l'échelle devra être aussi petite que possible sans nuire à la signification des résultats. Le présent article examine certains problèmes liés à l'extrapolation vers le bas d'un réacteur à écoulement ruisselant telle qu'elle est appliquée dans les procédés d'hydrotraitement à des réacteurs de laboratoire de tailles différentes cinétiquement équivalents. Deux aspects principaux relatifs à des inégalités de dynamique des fluides résultant de différences d'échelle sont décrits plus en détail, i. e. les écarts par rapport à un écoulement idéal donnant lieu à un effet bouchon et au mouillage ou à l'irrigation non-idéal des particules de catalyseur. Bien qu'un réacteur de laboratoire ne puisse jam

  13. Antalya Emniyet Müdürlüğü Hassas Bölgeleri Koruma Şube Müdürlüğü Personelinde Tükenmişlik Sendromu Üzerine Bir Çalişma

    OpenAIRE

    Kaya, Zeynel Abidin

    2014-01-01

    A Study On The Burn-Out Syndrome Observed Among The Personel Of The Sensitive Areas Protection Unit Of The Antalya Police ForceBurn-out syndrome, which has different causes and symptoms than stress and depression, and the concept of ”burn-out”, have been investigated since the 1980s. According to Masclach, burn-out syndrome, which consists of three subdimensions (emotional exhaustion, desentisization and a decrease in personal success), appears on emotional, behavioral and physical levels. Pe...

  14. Both rejection and tolerance of allografts can occur in the absence of secondary lymphoid tissues.

    Science.gov (United States)

    Kant, Cavit D; Akiyama, Yoshinobu; Tanaka, Katsunori; Shea, Susan; Yamada, Yohei; Connolly, Sarah E; Marino, Jose; Tocco, Georges; Benichou, Gilles

    2015-02-01

    In this study, we showed that aly/aly mice, which are devoid of lymph nodes and Peyer's patches, acutely rejected fully allogeneic skin and heart grafts. They mounted potent inflammatory direct alloresponses but failed to develop indirect alloreactivity after transplantation. Remarkably, skin allografts also were rejected acutely by splenectomized aly/aly (aly/aly-spl(-)) mice devoid of all secondary lymphoid organs. In these recipients, the rejection was mediated by alloreactive CD8(+) T cells presumably primed in the bone marrow. In contrast, cardiac transplants were not rejected by aly/aly-spl(-) mice. Actually, aly/aly-spl(-) mice that spontaneously accepted a heart allotransplant and displayed donor-specific tolerance also accepted skin grafts from the same, but not a third-party, donor via a mechanism involving CD4(+) regulatory T cells producing IL-10 cytokine. Therefore, direct priming of alloreactive T cells, as well as rejection and regulatory tolerance of allogeneic transplants, can occur in recipient mice lacking secondary lymphoid organs.

  15. Alcoholic liver injury:Influence of gender and hormones

    Institute of Scientific and Technical Information of China (English)

    Patricia; K; Eagon

    2010-01-01

    This article discusses several subjects pertinent to a consideration of the role of gender and hormones in alcoholic liver injury (ALI). Beginning with an overview of factors involved in the pathogenesis of ALI, we review changes in sex hormone metabolism resulting from alcohol ingestion, summarize research that points to estrogen as a cofactor in ALI, consider evidence that gut injury is linked to liver injury in the setting of alcohol, and briefly review the limited evidence regarding sex hormones and gut...

  16. Endovascular Management of Acute Limb Ischemia.

    LENUS (Irish Health Repository)

    Hynes, Brian G

    2011-09-14

    Despite major advances in pharmacologic and endovascular therapies, acute limb ischemia (ALI) continues to result in significant morbidity and mortality. The incidence of ALI may be as high as 13-17 cases per 100,000 people per year, with mortality rates approaching 18% in some series. This review will address the contemporary endovascular management of ALI encompassing pharmacologic and percutaneous interventional treatment strategies.

  17. Biomarkers in Acute Lung Injury

    OpenAIRE

    Bhargava, Maneesh; Wendt, Chris

    2012-01-01

    Acute Respiratory Distress Syndrome (ARDS) and Acute Lung Injury (ALI) result in high permeability pulmonary edema causing hypoxic respiratory failure with high morbidity and mortality. As the population ages, the incidence of ALI is expected to rise. Over the last decade, several studies have identified biomarkers in plasma and bronchoalveolar lavage fluid providing important insights into the mechanisms involved in the pathophysiology of ALI. Several biomarkers have been validated in subjec...

  18. Pharmacotherapy of Acute Lung Injury and Acute Respiratory Distress Syndrome

    OpenAIRE

    Raghavendran, Krishnan; Pryhuber, Gloria S.; Chess, Patricia R.; Davidson, Bruce A.; Paul R. Knight; Notter, Robert H.

    2008-01-01

    Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are characterized by rapid-onset respiratory failure following a variety of direct and indirect insults to the parenchyma or vasculature of the lungs. Mortality from ALI/ARDS is substantial, and current therapy primarily emphasizes mechanical ventilation and judicial fluid management plus standard treatment of the initiating insult and any known underlying disease. Current pharmacotherapy for ALI/ARDS is not optimal, a...

  19. Acute lung injury and ARDS in acute pancreatitis: Mechanisms and potential intervention

    Institute of Scientific and Technical Information of China (English)

    Roland; Andersson

    2010-01-01

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem,with a mortality rate in the range of 30%-40%.The present review evaluates underlying pathophysiological mechanisms in both ALI and ARDS and potential clinical implications.Several mediators and pathophysiological pathways are involved during the different phases of ALI and ARDS.The initial exudative phase is characterized by diffuse alveolar damage,microvascular injury and inf...

  20. Time-dependent changes of autophagy and apoptosis in lipopolysaccharide-induced rat acute lung injury

    OpenAIRE

    Li Lin; Lijun Zhang; Liangzhu Yu; Lu Han; Wanli Ji; Hui Shen; Zhenwu Hu

    2016-01-01

    Objective(s): Abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ALI). To identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (LPS)-induced ALI, we decided to evaluate autophagy (by LC3-II and autophagosome) and apoptosis (by caspase-3) at different time points after LPS treatment in a rat model of LPS-induced ALI. Materials and Methods: Sprague-Dawley ra...

  1. Experiment list: SRX065708 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available annel_1 || strain=OP217(official name : OP217 genotype : unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) outcross : 3 transgene... : aly-2 tags : Bombard tag : GFP::3xFlag description : This strain's transgene...genotype=unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) || Sex=Hermaphrodite || transgene

  2. Experiment list: SRX065717 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nnel_1 || strain=OP217(official name : OP217 genotype : unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) outcross : 3 transgene... : aly-2 tags : Bombard tag : GFP::3xFlag description : This strain's transgene...ype=unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) || Sex=Hermaphrodite || transgene

  3. Experiment list: SRX065707 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available annel_1 || strain=OP217(official name : OP217 genotype : unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) outcross : 3 transgene... : aly-2 tags : Bombard tag : GFP::3xFlag description : This strain's transgene...genotype=unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) || Sex=Hermaphrodite || transgene

  4. Experiment list: SRX065710 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nnel_1 || strain=OP217(official name : OP217 genotype : unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) outcross : 3 transgene... : aly-2 tags : Bombard tag : GFP::3xFlag description : This strain's transgene...enotype=unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) || Sex=Hermaphrodite || transgene

  5. Experiment list: SRX065709 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nnel_1 || strain=OP217(official name : OP217 genotype : unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) outcross : 3 transgene... : aly-2 tags : Bombard tag : GFP::3xFlag description : This strain's transgene...enotype=unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) || Sex=Hermaphrodite || transgene

  6. Experiment list: SRX065716 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available annel_1 || strain=OP217(official name : OP217 genotype : unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) outcross : 3 transgene... : aly-2 tags : Bombard tag : GFP::3xFlag description : This strain's transgene...type=unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) || Sex=Hermaphrodite || transgene

  7. Experiment list: SRX065715 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available annel_1 || strain=OP217(official name : OP217 genotype : unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) outcross : 3 transgene... : aly-2 tags : Bombard tag : GFP::3xFlag description : This strain's transgene...type=unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) || Sex=Hermaphrodite || transgene

  8. Experiment list: SRX065718 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nnel_1 || strain=OP217(official name : OP217 genotype : unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) outcross : 3 transgene... : aly-2 tags : Bombard tag : GFP::3xFlag description : This strain's transgene...ype=unc119(ed3);wgIs217(aly-2:TY1 EGFP FLAG;unc119) || Sex=Hermaphrodite || transgene

  9. Red blood cell transfusion and outcomes in patients with acute lung injury, sepsis and shock

    OpenAIRE

    Parsons, Elizabeth C.; Hough, Catherine L.; Seymour, Christopher W; Cooke, Colin R.; Rubenfeld, Gordon D.; Watkins, Timothy R

    2011-01-01

    Introduction In this study, we sought to determine the association between red blood cell (RBC) transfusion and outcomes in patients with acute lung injury (ALI), sepsis and shock. Methods We performed a secondary analysis of new-onset ALI patients enrolled in the Acute Respiratory Distress Syndrome Network Fluid and Catheter Treatment Trial (2000 to 2005) who had a documented ALI risk factor of sepsis or pneumonia and met shock criteria (mean arterial pressure (MAP) < 60 mmHg or vasopressor ...

  10. MicroRNA 16 Modulates Epithelial Sodium Channel in Human Alveolar Epithelial Cells

    OpenAIRE

    Parthasarathy, Prasanna Tamarapu; Galam, Lakshmi; Huynh, Bao; Yunus, Asfiya; Abuelenen, Toaa; Castillo, Annie; Ramanathan, Gurukumar Kollongod; Ruan, Cox; Kolliputi, Narasaiah

    2012-01-01

    Acute lung injury (ALI) is a devastating disease characterized by pulmonary edema. Removal of edema from the air spaces is a critical function of the epithelial sodium channel (ENaC) in ALI. The molecular mechanisms behind resolution of pulmonary edema are incompletely understood. MicroRNA’s (miRNA) are crucial gene regulators and are dysregulated in various diseases including ALI. Recent studies suggest that microRNA-16 (miR-16) targets serotonin transporter (SERT) involved in the serotonin ...

  11. VDR Attenuates Acute Lung Injury by Blocking Ang-2-Tie-2 Pathway and Renin-Angiotensin System

    OpenAIRE

    Kong, Juan; Zhu, Xiangdong; Shi, Yongyan; Liu, Tianjing; Chen, Yunzi; Bhan, Ishir; Zhao, Qun; Thadhani, Ravi; Li, Yan Chun

    2013-01-01

    Acute lung injury (ALI) is a hallmark of systemic inflammation associated with high mortality. Although the vitamin D receptor (VDR) is highly expressed in the lung, its role in lung physiology remains unclear. We investigated the effect of VDR deletion on ALI using a lipopolysaccharide (LPS)-induced sepsis model. After LPS challenge VDR-null mice exhibited more severe ALI and higher mortality compared with wild-type (WT) counterparts, manifested by increased pulmonary vascular leakiness, pul...

  12. Acute Lung Injury Induced by Lipopolysaccharide Is Independent of Complement Activation1

    OpenAIRE

    Rittirsch, Daniel; Flierl, Michael A; Day, Danielle E.; Nadeau, Brian A.; McGuire, Stephanie R.; Hoesel, Laszlo M.; Ipaktchi, Kyros; Zetoune, Firas S.; Sarma, J. Vidya; Leng, Lin; Huber-Lang, Markus S.; Neff, Thomas A.; Bucala, Richard; Ward, Peter A.

    2008-01-01

    Although acute lung injury (ALI) is an important problem in humans, its pathogenesis is poorly understood. Airway instillation of bacterial LPS, a known complement activator, represents a frequently used model of ALI. In the present study, pathways in the immunopathogenesis of ALI were evaluated. ALI was induced in wild-type, C3–/–, and C5–/– mice by airway deposition of LPS. To assess the relevant inflammatory mediators, bronchoalveolar lavage fluids were evaluated by ELISA analyses and vari...

  13. Discovery of the gene signature for acute lung injury in patients with sepsis Address for reprint requests and other correspondence: J. A. Howrylak, UPMC Montefiore NW 628, 3459 5th Ave., Pittsburgh, PA 15213 (e-mail: howrylakj@upmc.edu).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    Science.gov (United States)

    Howrylak, Judie A.; Dolinay, Tamas; Lucht, Lorrie; Wang, Zhaoxi; Christiani, David C.; Sethi, Jigme M.; Xing, Eric P.; Donahoe, Michael P.; Choi, Augustine M. K.

    2009-01-01

    The acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) was described 30 yr ago, yet making a definitive diagnosis remains difficult. The identification of biomarkers obtained from peripheral blood could provide additional noninvasive means for diagnosis. To identify gene expression profiles that may be used to classify patients with ALI, 13 patients with ALI + sepsis and 20 patients with sepsis alone were recruited from the Medical Intensive Care Unit of the University of Pittsburgh Medical Center, and microarrays were performed on peripheral blood samples. Several classification algorithms were used to develop a gene signature for ALI from gene expression profiles. This signature was validated in an independently obtained set of patients with ALI + sepsis (n = 8) and sepsis alone (n = 1). An eight-gene expression profile was found to be associated with ALI. Internal validation found that the gene signature was able to distinguish patients with ALI + sepsis from patients with sepsis alone with 100% accuracy, corresponding to a sensitivity of 100%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 100%. In the independently obtained external validation set, the gene signature was able to distinguish patients with ALI + sepsis from patients with sepsis alone with 88.9% accuracy. The use of classification models to develop a gene signature from gene expression profiles provides a novel and accurate approach for classifying patients with ALI. PMID:19174476

  14. Lipocalin-2 Test in Distinguishing Acute Lung Injury Cases from Septic Mice Without Acute Lung Injury

    Institute of Scientific and Technical Information of China (English)

    Gao Zeng; Cong-wei Jia; Jie Liu; Shu-bin Guo

    2014-01-01

    Objective To explore whether the amount of lipocalin-2 in the biofluid could reflect the onset of sepsis-induced acute lung injury (ALI) in mice. Methods Lipopolysaccharide (LPS, 10 mg/kg) injection or cecal ligation and puncture (CLP) was performed to induce severe sepsis and ALI in C57 BL/6 male mice randomly divided into 5 groups (n=10 in each group):group A (intraperitoneal LPS injection), group B (intravenous LPS injection via tail vein), group C (CLP with 25%of the cecum ligated), group D (CLP with 75%of the cecum ligated), and the control group (6 sham-operation controls plus 4 saline controls). All the mice received volume resuscitation. Measurements of pulmonary morphological and functional alterations were used to identify the presence of experimental ALI. The expressions of lipocalin-2 and interleukin (IL)-6 in serum, bronchoalveolar lavage fluid (BALF), and lung tissue were quantified at both protein and mRNA levels. The overall abilities of lipocalin-2 and IL-6 tests to diagnose sepsis-induced ALI were evaluated by generating receiver operator characteristic curves (ROC) and computing area under curve (AUC). Results In both group B and group D, most of the“main features”of experimental ALI were reproduced in mice, while group A and group C showed septic syndrome without definite evidence for the presence of ALI. Compared with septic mice without ALI (group A+group C), lipocalin-2 protein expression in septic mice with ALI (group B+group D) was significantly up-regulated in BALF (P Conclusions Lipocalin-2 expression is significantly up-regulated in septic ALI mice compared with those without ALI. Lipocalin-2 tests with a dual cutoff system could be an effective tool in distinguishing experimental ALI cases.

  15. I nipoti di Gutenberg / di Mariarosa Rosi : a colloquio con Mauro Guerrini. --- Prima del titolo: Biblioteca digitale online. --- Titoli sulle pagine seguenti: "Dante e Petrarca, Leopardi e Manzoni, Keplero e Galilei: l'accordo tra Italia e Google ha dato le ali a molti testi preziosi. Un matrimonio di interesse reciproco. Il sogno? Un catalogo unico" (p. 19 e 21) "Copyright e modelli di tutela. Se ne discute ancora. Peter Suber: il web del futuro? Sostenibile e trasparente" (p. 23).

    OpenAIRE

    Mauro Guerrini

    2013-01-01

    In 1971 an American computer technician, Michael Hart, realized that the biggest computer’s potentiality was the access trough the web to everything preserved in libraries, archives and museum. So “Project Gutenberg” was born and so following numerous projects in others countries. The biggest one is Google Books, born in 2000. Digital library shows new problems about technical perspectives (information compatibility), legal perspectives (copyright) and socio-environmental perspectives (energy...

  16. The risk of acute liver injury among users of antibiotic medications in the protect project: The results of a nested case-control study using european outpatient healthcare data

    NARCIS (Netherlands)

    Brauer, Ruth; Douglas, Ian; Rodriguez, Luis Alberto Garcia; Bate, Andrew; Smeeth, Liam; Reynolds, Robert; Klungel, Olaf; Ruigomez, Ana

    2014-01-01

    Background: The estimated incidence of antibiotic induced acute liver injury (ALI) varies widely, depending on the case definition and source population used. Objectives: We aimed to compare the risk of ALI associated with exposure to any type of antibiotic in a Spanish and United Kingdom (UK) datab

  17. Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy.

    Directory of Open Access Journals (Sweden)

    Masashi Aizawa

    Full Text Available Previous clinical and experimental studies have indicated that cells responsible for IgA nephropathy (IgAN, at least in part, are localized in bone marrow (BM. Indeed, we have demonstrated that murine IgAN can be experimentally reconstituted by bone marrow transplantation (BMT from IgAN prone mice in not only normal mice, but also in alymphoplasia mice (aly/aly independent of IgA+ cells homing to mucosa or secondary lymphoid tissues. The objective of the present study was to further assess whether secondary lymph nodes (LN contribute to the progression of this disease. BM cells from the several lines of IgAN prone mice were transplanted into aly/aly and wild-type mice (B6. Although the transplanted aly/aly showed the same degree of mesangial IgA and IgG deposition and the same serum elevation levels of IgA and IgA-IgG immune-complexes (IC as B6, even in extent, the progression of glomerular injury was observed only in B6. This uncoupling in aly/aly was associated with a lack of CD4+ T cells and macrophage infiltration, although phlogogenic capacity to nephritogenic IC of renal resident cells was identical between both recipients. It is suggested that secondary LN may be required for the full progression of IgAN after nephritogenic IgA and IgA/IgG IC deposition.

  18. Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastography

    NARCIS (Netherlands)

    Stravitz, R. Todd; Lisman, Ton; Luketic, Velimir A.; Sterling, Richard K.; Puri, Puneet; Fuchs, Michael; Ibrahim, Ashraf; Lee, William M.; Sanyal, Arun J.

    2012-01-01

    Background & Aims: Patients with acute liver injury/failure (ALI/ALF) are assumed to have a bleeding diathesis on the basis of elevated INR; however, clinically significant bleeding is rare. We hypothesized that patients with ALI/ALF have normal hemostasis despite elevated INR. Methods: Fifty-one pa

  19. Alveolar epithelial cells (A549) exposed at the air-liquid interface to diesel exhaust: First study in TNO's powertrain test center

    NARCIS (Netherlands)

    Kooter, I.M.; Alblas, M.J.; Jedynska, A.D.; Steenhof, M.; Houtzager, M.M.G.; Ras, M.G. van

    2013-01-01

    Air–liquid interface (ALI) exposures enable in vitro testing ofmixtures of gases and particles such as diesel exhaust (DE). The main objective of this study was to investigate the feasibility of exposing human lung epithelial cells at the ALI to complete DE generated by a heavy-duty truck in the sta

  20. Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection

    NARCIS (Netherlands)

    R.A. Bem; J.B.M. van Woensel; A.P. Bos; A. Koski; A.W. Farnand; J.B. Domachowske; H.F. Rosenberg; T.R. Martin; G. Matute-Bello

    2009-01-01

    Severe infection with respiratory syncytial virus (RSV) in children can progress to respiratory distress and acute lung injury (ALI). Accumulating evidence suggests that mechanical ventilation (MV) is an important cofactor in the development of ALI by modulating the host immune responses to bacteria

  1. Clinical analysis of acute lung injury after esophagectomy

    Directory of Open Access Journals (Sweden)

    Wei-chun Wu

    2014-01-01

    Conclusion: Greater surgical stress, such as a longer operative time, is thus considered to be associated with the first attack of ALI. The adverse events developing in the extrathoracic site, such as necrosis and local infection around anastomosis may, therefore, be the second attack. Furthermore, ALI may cause not only systemic inflammatory response syndrome but also other complications such as anastomotic leakage.

  2. Association between insertion/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury/acute respiratory distress syndrome: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Matsuda Akihisa

    2012-08-01

    Full Text Available Abstract Background A previous meta-analysis reported a positive association between an insertion/deletion (I/D polymorphism in the angiotensin-converting enzyme gene (ACE and the risk of acute lung injury (ALI/acute respiratory distress syndrome (ARDS. Here, we updated this meta-analysis and additionally assessed the association of this polymorphism with ALI/ARDS mortality. Methods We searched electronic databases through October 2011 for the terms “angiotensin-converting enzyme gene”, “acute lung injury”, and “acute respiratory distress syndrome,” and reviewed all studies that reported the relationship of the I/D polymorphism in ACE with ALI/ARDS in humans. Seven studies met the inclusion criteria, comprising 532 ALI/ARDS patients, 3032 healthy controls, and 1432 patients without ALI/ARDS. We used three genetic models: the allele, dominant, and recessive models. Results The ACE I/D polymorphism was not associated with susceptibility to ALI/ARDS for any genetic model. However, the ACE I/D polymorphism was associated with the mortality risk of ALI/ARDS in Asian subjects ( Pallele Pdominant = 0.001, Precessive = 0.002. This finding remained significant after correction for multiple comparisons. Conclusions There is a possible association between the ACE I/D polymorphism genotype and the mortality risk of ALI/ARDS in Asians.

  3. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... group. So it really was just this constant go, go, go.” In high school, after feeling soreness and pain ... quality life. Aly Becker Aly is still the go-getter she was as a kid despite her ...

  4. Biomarkers in acute lung injury.

    Science.gov (United States)

    Mokra, Daniela; Kosutova, Petra

    2015-04-01

    Acute respiratory distress syndrome (ARDS) and its milder form acute lung injury (ALI) may result from various diseases and situations including sepsis, pneumonia, trauma, acute pancreatitis, aspiration of gastric contents, near-drowning etc. ALI/ARDS is characterized by diffuse alveolar injury, lung edema formation, neutrophil-derived inflammation, and surfactant dysfunction. Clinically, ALI/ARDS is manifested by decreased lung compliance, severe hypoxemia, and bilateral pulmonary infiltrates. Severity and further characteristics of ALI/ARDS may be detected by biomarkers in the plasma and bronchoalveolar lavage fluid (or tracheal aspirate) of patients. Changed concentrations of individual markers may suggest injury or activation of the specific types of lung cells-epithelial or endothelial cells, neutrophils, macrophages, etc.), and thereby help in diagnostics and in evaluation of the patient's clinical status and the treatment efficacy. This chapter reviews various biomarkers of acute lung injury and evaluates their usefulness in diagnostics and prognostication of ALI/ARDS.

  5. The Sclerotic Scatter Limbal Arc Is More Easily Elicited under Mesopic Rather Than Photopic Conditions.

    Directory of Open Access Journals (Sweden)

    Eric Denion

    Full Text Available We aimed to determine the limbal lighting illuminance thresholds (LLITs required to trigger perception of sclerotic scatter at the opposite non-illuminated limbus (i.e. perception of a light limbal scleral arc under different levels of ambient lighting illuminance (ALI.Twenty healthy volunteers were enrolled. The iris shade (light or dark was graded by retrieving the median value of the pixels of a pre-determined zone of a gray-level iris photograph. Mean keratometry and central corneal pachymetry were recorded. Each subject was asked to lie down, and the ALI at eye level was set to mesopic values (10, 20, 40 lux, then photopic values (60, 80, 100, 150, 200 lux. For each ALI level, a light beam of gradually increasing illuminance was applied to the right temporal limbus until the LLIT was reached, i.e. the level required to produce the faint light arc that is characteristic of sclerotic scatter at the nasal limbus.After log-log transformation, a linear relationship between the logarithm of ALI and the logarithm of the LLIT was found (p<0.001, a 10% increase in ALI being associated with an average increase in the LLIT of 28.9%. Higher keratometry values were associated with higher LLIT values (p = 0.008 under low ALI levels, but the coefficient of the interaction was very small, representing a very limited effect. Iris shade and central corneal thickness values were not significantly associated with the LLIT. We also developed a censored linear model for ALI values ≤ 40 lux, showing a linear relationship between ALI and the LLIT, in which the LLIT value was 34.4 times greater than the ALI value.Sclerotic scatter is more easily elicited under mesopic conditions than under photopic conditions and requires the LLIT value to be much higher than the ALI value, i.e. it requires extreme contrast.

  6. Change and significance of plasma surfactant protein D level in patients with severe multiple trauma combined with acute lung injury%严重多发伤并发急性肺损伤患者血浆中肺表面活性物质相关蛋白D的变化及意义

    Institute of Scientific and Technical Information of China (English)

    王白云; 徐道妙

    2008-01-01

    Objective To dynamically measure level of surfactant protein D(SP-D)in patients with severe multiple trauma and discuss the relationship between SP-D and acute lung injury(ALI)/ARDS and its clinical significance. Methods A total of 36 patients with severe multiple trauma were divided into ALI/ARDS group(20 patients)and non-ALI/ARDS group(16 patients).Peripheral blood samples were collected at days 1,3,7 and 14 after trauma for calculating lung injury score(LIS)and PaO2/FiO2 ratio.Another 12 healthy persons were served as control group.Plasma SP-D levels were measured by using enzyme linked immunoabsorbent assay(ELISA). Results The plasma SP-D levels in ALI/ARDS group were markedly higher than those of control group and non-ALI/ARDS group(P<0.01).In ALI/ARDS group,the plasma SP-D levels in severe lung injury group were significantly higher than those of modcrate lung injury group(P<0.05).The plasma SP-D levels in ALI/ARDS group were inversely related to their PaO2/FiO2 ratios(rs=-0.745,P<0.01). Conclusions The plasma SP-D level is relevant not only to the occurrence of traumatic ALI/ARDS after multiple trauma,but also closely to the severity of lung injury,indicating that plasma SP-D is a valuable biomarker in ALI/ARDS.%目的 动态观测严重多发伤患者血浆中肺表面活性物质相关蛋白D(SP-D)水平并探讨它与创伤性急性肺损伤(ALI)/ARDS之间的关系及意义.方法 将36例严重多发伤患者分为多发伤后并发ALI/ARDS组20例(ALI/ARDS组)与多发伤后未并发ALI/ARDS组16例(非ALI/ARDS组).分别于伤后第1,3,7,14天收集外周血;同时计算PaO2/FiO2并行肺损伤评分;另12例体检健康者设为正常对照组.运用ELISA测定血浆SP-D的浓度.结果 ALI/ARDS组患者血浆SP-D水平显著高于正常对照组和非ALI/ARDS组(P<0.01);ALI/ARDS患者重度肺损伤组血浆SP-D水平明显高于中度肺损伤组(P<0.05);SP-D水平与其相应的PaO2/FiO2呈负相关关系(rs=-0.745,P<0.01).结论 严重多发伤

  7. Human models of acute lung injury

    Directory of Open Access Journals (Sweden)

    Alastair G. Proudfoot

    2011-03-01

    Full Text Available Acute lung injury (ALI is a syndrome that is characterised by acute inflammation and tissue injury that affects normal gas exchange in the lungs. Hallmarks of ALI include dysfunction of the alveolar-capillary membrane resulting in increased vascular permeability, an influx of inflammatory cells into the lung and a local pro-coagulant state. Patients with ALI present with severe hypoxaemia and radiological evidence of bilateral pulmonary oedema. The syndrome has a mortality rate of approximately 35% and usually requires invasive mechanical ventilation. ALI can follow direct pulmonary insults, such as pneumonia, or occur indirectly as a result of blood-borne insults, commonly severe bacterial sepsis. Although animal models of ALI have been developed, none of them fully recapitulate the human disease. The differences between the human syndrome and the phenotype observed in animal models might, in part, explain why interventions that are successful in models have failed to translate into novel therapies. Improved animal models and the development of human in vivo and ex vivo models are therefore required. In this article, we consider the clinical features of ALI, discuss the limitations of current animal models and highlight how emerging human models of ALI might help to answer outstanding questions about this syndrome.

  8. MicroRNA Regulation of Acute Lung Injury and Acute Respiratory Distress Syndrome.

    Science.gov (United States)

    Rajasekaran, Subbiah; Pattarayan, Dhamotharan; Rajaguru, P; Sudhakar Gandhi, P S; Thimmulappa, Rajesh K

    2016-10-01

    The acute respiratory distress syndrome (ARDS), a severe form of acute lung injury (ALI), is a very common condition associated with critically ill patients, which causes substantial morbidity and mortality worldwide. Despite decades of research, effective therapeutic strategies for clinical ALI/ARDS are not available. In recent years, microRNAs (miRNAs), small non-coding molecules have emerged as a major area of biomedical research as they post-transcriptionally regulate gene expression in diverse biological and pathological processes, including ALI/ARDS. In this context, this present review summarizes a large body of evidence implicating miRNAs and their target molecules in ALI/ARDS originating largely from studies using animal and cell culture model systems of ALI/ARDS. We have also focused on the involvement of miRNAs in macrophage polarization, which play a critical role in regulating the pathogenesis of ALI/ARDS. Finally, the possible future directions that might lead to novel therapeutic strategies for the treatment of ALI/ARDS are also reviewed. J. Cell. Physiol. 231: 2097-2106, 2016. © 2016 Wiley Periodicals, Inc. PMID:26790856

  9. Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation.

    Directory of Open Access Journals (Sweden)

    Jochen Grommes

    Full Text Available INTRODUCTION: Treatment of acute lung injury (ALI remains an unsolved problem in intensive care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored its effects on development of ALI and due to the importance of neutrophils in ALI also on neutrophil effector functions. METHODS: C57Bl/6 mice were exposed to aerosolized LPS (500 µg/ml for 30 min. The count of alveolar, interstitial, and intravasal neutrophils were assessed 4 h later by flow cytometry. Lung permeability changes were assessed by FITC-dextran clearance and albumin content in the BAL fluid. In vitro, we analyzed the effect of simvastatin on neutrophil adhesion, degranulation, apoptosis, and formation of reactive oxygen species. To monitor effects of simvastatin on bacterial clearance we performed phagocytosis and bacterial killing studies in vitro as well as sepsis experiments in mice. RESULTS: Simvastatin treatment before and after onset of ALI reduces neutrophil influx into the lung as well as lung permeability indicating the protective role of simvastatin in ALI. Moreover, simvastatin reduces the formation of ROS species and adhesion of neutrophils without affecting apoptosis, bacterial phagocytosis and bacterial clearance. CONCLUSION: Simvastatin reduces recruitment and activation of neutrophils hereby protecting from LPS-induced ALI. Our results imply a potential role for statins in the management of ALI.

  10. Subsurface Imaging by UWB Radar: Application to Humanitarian Demining in Cambodia

    Science.gov (United States)

    Sato, Motoyuki

    Ground Penetrating Radar (GPR) has been widely used applications which include detection of subsurface facilities, concrete inspection and archaeology. Among these applications, humanitarian demining is still difficult task. Since 2002, we have developed a new hand-held land mine detection dual-sensor ALIS. ALIS is equipped with a metal detector and a GPR, and it has a sensor tracking system, which can record the GPR and Metal detector signal with its location. ALIS can process the data and is used for image re-construction by migration processing. ALIS is the only one mine detection system in the world which can visualize the GPR image by hand scanning. We found that the migration processing can reduce the clutter and gives us clear images of buried mines. After several tests of ALIS in mine affected courtiers, operation of ALIS in mine fields in Cambodia started in summer 2009. Two sets of ALIS have been operated in Cambodia and more than 77 antipersonnel mines have been detected and 137,000m2 farmland was cleaned.

  11. Transmission Dynamics of Visceral Leishmaniasis in the Indian Subcontinent – A Systematic Literature Review

    Science.gov (United States)

    Boelaert, Marleen; Matlashewski, Greg; Mondal, Dinesh; Arana, Byron; Kroeger, Axel; Olliaro, Piero

    2016-01-01

    Background As Bangladesh, India and Nepal progress towards visceral leishmaniasis (VL) elimination, it is important to understand the role of asymptomatic Leishmania infection (ALI), VL treatment relapse and post kala-azar dermal leishmaniasis (PKDL) in transmission. Methodology/ Principal Finding We reviewed evidence systematically on ALI, relapse and PKDL. We searched multiple databases to include studies on burden, risk factors, biomarkers, natural history, and infectiveness of ALI, PKDL and relapse. After screening 292 papers, 98 were included covering the years 1942 through 2016. ALI, PKDL and relapse studies lacked a reference standard and appropriate biomarker. The prevalence of ALI was 4–17-fold that of VL. The risk of ALI was higher in VL case contacts. Most infections remained asymptomatic or resolved spontaneously. The proportion of ALI that progressed to VL disease within a year was 1.5–23%, and was higher amongst those with high antibody titres. The natural history of PKDL showed variability; 3.8–28.6% had no past history of VL treatment. The infectiveness of PKDL was 32–53%. The risk of VL relapse was higher with HIV co-infection. Modelling studies predicted a range of scenarios. One model predicted VL elimination was unlikely in the long term with early diagnosis. Another model estimated that ALI contributed to 82% of the overall transmission, VL to 10% and PKDL to 8%. Another model predicted that VL cases were the main driver for transmission. Different models predicted VL elimination if the sandfly density was reduced by 67% by killing the sandfly or by 79% by reducing their breeding sites, or with 4–6y of optimal IRS or 10y of sub-optimal IRS and only in low endemic setting. Conclusion/ Significance There is a need for xenodiagnostic and longitudinal studies to understand the potential of ALI and PKDL as reservoirs of infection. PMID:27490264

  12. Discovery of a Novel Alginate Lyase from Nitratiruptor sp. SB155-2 Thriving at Deep-sea Hydrothermal Vents and Identification of the Residues Responsible for Its Heat Stability.

    Science.gov (United States)

    Inoue, Akira; Anraku, Moe; Nakagawa, Satoshi; Ojima, Takao

    2016-07-22

    Extremophiles are expected to represent a source of enzymes having unique functional properties. The hypothetical protein NIS_0185, termed NitAly in this study, was identified as an alginate lyase-homolog protein in the genomic database of ϵ-Proteobacteria Nitratiruptor sp. SB155-2, which was isolated from deep-sea hydrothermal vents at a water depth of 1,000 m. Among the characterized alginate lyases in the polysaccharide lyase family 7 (PL-7), the amino acid sequence of NitAly showed the highest identity (39%) with that of red alga Pyropia yezoensis alginate lyase PyAly. Recombinant NitAly (rNitAly) was successfully expressed in Escherichia coli Purified rNitAly degraded alginate in an endolytic manner. Among alginate block types, polyM was preferable to polyG and polyMG as a substrate, and its end degradation products were mainly tri-, tetra-, and penta-saccharides. The optimum temperature and pH values were 70 °C and around 6, respectively. A high concentration of NaCl (0.8-1.4 m) was required for maximum activity. In addition, a 50% loss of activity was observed after incubation at 67 °C for 30 min. Heat stability was decreased in the presence of 5 mm DTT, and Cys-80 and Cys-232 were identified as the residues responsible for heat stability but not lyase activity. Introducing two cysteines into PyAly based on homology modeling using Pseudomonas aeruginosa alginate lyase PA1167 as the template enhanced its heat stability. Thus, NitAly is a functional alginate lyase, with its unique optimum conditions adapted to its environment. These insights into the heat stability of NitAly could be applied to improve that of other PL-7 alginate lyases. PMID:27231344

  13. PAVING THE WAY FOR INTERRELIGIOUS DIALOGUE, TOLERANCE, AND HARMONY: Following Mukti Ali’s Path

    Directory of Open Access Journals (Sweden)

    Faisal Ismail

    2012-01-01

    Full Text Available A known Indonesian Muslim scholar Mukti Ali (1923-2004 was very much concerned with dialogue, tolerance, and harmony among the people of different traditions, cultures, and religions. In his many academic works, he stressesed the importance of promoting, strengthening, and maintaining intercultural and interreligious dialogue, tolerance, and harmony. Not only did he produce various academic works, but also made efforts in putting his intercultural and interreligious ideas into practice. Both as a scholar and expert in the comparative study of religions and as Minister of Religious Affairs of the Republic of Indonesia (1971-1978, Mukti Ali endlessly promoted intercultural and interreligiuos diologue, tolerance, and harmony. Realizing that Indonesia is a pluralistic society, Mukti Ali adopted an approach called ‘agree in disagreement’ in the effort of creating and supporting tolerance, harmony, and security among people of different religious traditions. This paper will highlight the principles and values which Mukti Ali struggled for during his long administrative and academic careers.[Mukti Ali (1923-2004 adalah salah seorang intelektual Muslim ternama di Indonesia. Dia dedikasikan hidupnya untuk menyemai dialog, toleransi dan kehidupan harmonis antar tradisi, budaya dan agama yang beragam. Dalam berbagai karya akademiknya, Mukti Ali selalu menekankan pentingnya kehidupan harmonis dan toleransi antar pemeluk agama dan budaya. Lebih dari itu, dia melampaui hanya sekedar batas pemikiran dengan mengimplementasikan gagasan-gagasannya tersebut. Sebagai seorang ilmuwan dengan keahlian perbandingan agama dan sebagai Menteri Agama RI (1971-1978, Mukti Ali dengan kukuh memperjuangkan dialog, toleransi dan kehidupan harmonis antar agama dan budaya. Mukti Ali sadar, Indonesia adalah negara yang plural, karena itu dia menawarkan pendekatan “agree in disagreement” untuk menciptakan harmoni dan toleransi tersebut. Tulisan ini mengulas prinsip dan

  14. Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.

    Directory of Open Access Journals (Sweden)

    Fiona E Lovegrove

    2008-05-01

    Full Text Available Although acute lung injury (ALI is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria (CM; however, no model of malaria-induced lung injury has been definitively established. This study used bronchoalveolar lavage (BAL, histopathology and gene expression analysis to examine the development of ALI in mice infected with Plasmodium berghei ANKA (PbA. BAL fluid of PbA-infected C57BL/6 mice revealed a significant increase in IgM and total protein prior to the development of CM, indicating disruption of the alveolar-capillary membrane barrier-the physiological hallmark of ALI. In contrast to sepsis-induced ALI, BAL fluid cell counts remained constant with no infiltration of neutrophils. Histopathology showed septal inflammation without cellular transmigration into the alveolar spaces. Microarray analysis of lung tissue from PbA-infected mice identified a significant up-regulation of expressed genes associated with the gene ontology categories of defense and immune response. Severity of malaria-induced ALI varied in a panel of inbred mouse strains, and development of ALI correlated with peripheral parasite burden but not CM susceptibility. Cd36(-/- mice, which have decreased parasite lung sequestration, were relatively protected from ALI. In summary, parasite burden and CD36-mediated sequestration in the lung are primary determinants of ALI in experimental murine malaria. Furthermore, differential susceptibility of mouse strains to malaria-induced ALI and CM suggests that distinct genetic determinants may regulate susceptibility to these two important causes of malaria-associated morbidity and mortality.

  15. PEVSKI ZBOR KOT OBOGATITVENA DEJAVNOST V VRTCU

    OpenAIRE

    Škorjanc, Nina

    2015-01-01

    Glasba nas čustveno bogati, je pozitivna terapija za dušo, kadar smo žalostni, nas pomiri in razbremeni. Z glasbo se nekateri dojenčki srečajo že v prenatalnem obdobju, zahvaljujoč predvsem mamicam, ki v nosečnosti intenzivno poslušajo glasbo, prepevajo pesmi ali igrajo na instrument. Po rojstvu je od vsakega otroka, ki mu je bilo to dano, odvisno ali bo informacije, ki jih je sprejel v maminem trebuhu nadgradil ali zatrl. Otroci radi pojejo, saj jih petje sprošča in razveseljuje. Zato je...

  16. POVEZANOST MED NOTRANJO TRŽNO NARAVNANOSTJO IN ZUNANJO TRŽNO NARAVNANOSTJO V PODJETJIH V SLOVENIJI

    OpenAIRE

    Kralj Palka, Vlasta

    2012-01-01

    Vsa podjetja ali organizacije, ki delujejo na spreminjajočih se trgih, se morajo nenehno bolj ali manj spreminjati in uvajati novosti na vseh ravneh znotraj organizacije, kot tudi odjemalcem ponujati nove in spremenjene izdelke ali storitve. V organizacijah, kjer imajo zadovoljne zaposlene, vsekakor lažje in hitreje pridejo do boljših rezultatov pri prodaji, kar hkrati krepi položaj na trgu. Notranja tržna naravnanost predstavlja vse napore, dejavnosti in delovanja v podjetju, ki se nana...

  17. Profesinių centrų veiklos ypatumai kaitos sąlygomis

    OpenAIRE

    Kniežaitė, Živilė

    2011-01-01

    Profesinio rengimo tinklo veiklos tobulinimo problema kaitos kontekste Lietuvoje kaip niekada yra aktuali. EUROSTAT duomenimis, Lietuva yra tarp trijų labiausiai atsiliekančių Europos Sąjungos šalių pagal darbo jėgos dalyvavimą formaliajame ir neformaliajame mokyme. Šalies profesinio rengimo sektorius nespėja reaguoti į aplinkos pokyčius ir šalies ūkio poreikius, t.y. trūksta kvalifikuotų darbininkų, paslaugų sektoriaus darbuotojų, aukštos kvalifikacijos specialistų. Tyrimo objektas: prof...

  18. Poročanje o tveganjih in njihovem obvladovanju v letnih poročilih - primer Thermana d.d.

    OpenAIRE

    Pušnik, Zlatka

    2016-01-01

    Tveganje je verjetnost, da bo rezultat naše poslovne odločitve drugačen od pričakovanega za nas najbolj verjetnega. Podjetje tvega, da se poslovna zamisel delno uresniči ali pa se sploh ne. Od uspešnosti obvladovanja tveganj je odvisno, ali bo podjetje uspešno ali ne. Predstaviti želimo, kako pomembne so kakovostne informacije v letnih poročilih zlasti pri komuniciranju z zunanjimi uporabniki poslovnih informacij. Na podlagi poročanj o tveganjih v letnih poročilih si lahko zunanji uporabn...

  19. VRLINE V POSLOVNEM SVETU: RADODARNOST

    OpenAIRE

    Sovinc, Darinka

    2016-01-01

    Diplomsko delo obravnava problematiko vrlin v poslovnem svetu, s posebnim poudarkom na radodarnosti. V teoretičnem delu je osnovni namen predstaviti pojem vrline in radodarnost kot ene izmed njih ter jo povezati z utilitarizmom in deontološko teorijo. Osredotočili smo se na poslovno etiko, ki smo jo poskušali povezati z nekaterimi etičnimi teorijami. Poskušali smo ugotoviti prisotnost vrlin v poslovnem svetu in ali je možno govoriti o prisotnosti radodarnosti v poslovnem svetu. Izhajali smo i...

  20. REVIZORJEVI POSTOPKI V ZVEZI S PREVARAMI

    OpenAIRE

    Banovšek, Maja

    2011-01-01

    Prevaro MSR 240 (2009) opredeljuje kot namerno dejanje enega ali več članov poslovodstva, pristojnih za upravljanje, zaposlenih ali tretjih oseb, da z goljufijo pridobijo neupravičene ali nezakonite koristi. Glavno odgovornost za preprečevanje in odkrivanje prevar imajo tako pristojni za upravljanje organizacije kot poslovodstvo. Pomembno je, da daje poslovodstvo ob nadziranju, ki ga izvajajo pristojni za upravljanje, velik poudarek preprečevanju prevar, kar lahko zmanjšuje priložnosti za ...

  1. ODŠKODNINSKA ODGOVORNOST DELODAJALCA ZARADI POŠKODB PRI DELU V REPUBLIKI SLOVENIJI IN MOŽNOST SKLENITVE ZAVAROVANJA

    OpenAIRE

    Miklavčič Podbelšek, Marjana

    2011-01-01

    POVZETEK Pri kakršnem koli ravnanju človeka ali opravljanju sleherne dejavnosti, dela oz. lahko nastane škoda, ki jo ima oškodovanec ob določenih pogojih pravico dobiti povrnjeno. Enako je lahko v situaciji pri delu delavca, v delovnem razmerju, s tem da je delavec lahko povzročitelj škode ali oškodovanec na drugi strani. Zakon o delovnih razmerjih ureja primere, ko delavec na delu ali v zvezi z delom delodajalcu povzroči škodo, vendar delavec odgovarja za nastanek škode le, če je ško...

  2. VPLIV CENE NA ZADOVOLJSTVO IN ZVESTOBO UPORABNIKOV TELEKOMUNIKACIJSKIH STORITEV

    OpenAIRE

    Majcen, Mateja

    2016-01-01

    Cena izdelka ali storitve, ki jo plača uporabnik, ima pomemben vpliv na zadovoljstvo ali nezadovoljstvo uporabnika z uporabo tega izdelka ali storitve in posledično na zadovoljstvo do podjetja. Glede na to, da se različni avtorji strinjajo in to tudi dokazujejo z raziskavami, zadovoljstvo nedvoumno vpliva na zvestobo uporabnika, zvestoba pa na dolgoročno uspešnost podjetja, smo v delu ugotavljali, kako sama cena storitve vpliva na zadovoljstvo in kako posredno preko zadovoljstva vpliva na zve...

  3. IZDELAVA SPLETNE TRGOVINE ZA PODJETJE ŽGANJEKUHA ŽAN FRANC S.P.

    OpenAIRE

    Bergant, David

    2012-01-01

    Podjetje Žganjekuha Žan Franc, s. p., želi povečati prodajo svojih izdelkov predvsem fizičnim osebam, ki trenutno odkupijo manj kot 10 odstotkov vseh njihovih izdelkov. Zaradi večje proizvodne zmogljivosti bi radi povečali prodajo tudi pravnim osebam, saj jim novi proizvodni obrat to omogoča. Ker podjetje še ni prisotno na spletu, smo se odločili za izdelavo spletne trgovine, s pomočjo katere bi prodajo zagotovo povečali, poleg tega pa tudi olajšali stik s potencialnimi strankami. Ker ponudba...

  4. Vsebinsko in jezikovno integrirano učenje pri pouku angleškega jezika v petem razredu osnovne šole

    OpenAIRE

    Žanet, Pavlica

    2015-01-01

    Vsebinsko in jezikovno integrirano učenje (VJIU) ali CLIL (ang. Content and Language Integrated Learning), ki je krovno poimenovanje za odprt didaktični pristop pouka, kjer se vse ali zgolj določene vsebine nejezikovnega predmeta ali predmetov obravnavajo v ciljnem jeziku, je ena od najbolj učinkovitih poti za doseganje evropske politike večjezičnosti. V teoretičnem delu magistrskega dela smo opredelili didaktični pristop VJIU, njegove oblike izvajanja, prednosti in slabosti, njegovo zgod...

  5. OSINT - študija primera WIKILEAKS in študija primera SUPERVIZOR : diplomsko delo univerzitetnega študija

    OpenAIRE

    Mahne, Katja

    2013-01-01

    Supervizor na nacionalni in Wikileaks na svetovni ravni danes predstavljata sredstvi za lažje finančno, politično ali vse svetovno poznavanje dogajanja v državi ali v svetu. Aplikacija Supervizor nam omogoča, da lahko kadarkoli preverimo, koliko denarja je dobila osnovna šola v našem kraju ali morda koliko je podjetje našega soseda prejelo od države za urejanje vrtov. V nasprotju s finančnimi tokovi nam Wikileaks razkriva, kaj sta se na poslovnem kosilu pogovarjala ameriški minister in na...

  6. Cilt 2, Sayı 4, Bahar 2014

    OpenAIRE

    ,

    2014-01-01

    Abdüsselam UYGUR (Tunceli Üniversitesi) Adem ASALIOĞLU (Tunceli Üniversitesi) Ahmet Kerim GÜLTEKİN (Tunceli Üniversitesi) Ahmet UZUN (Cumhuriyet Üniversitesi) Ahmet Yaşar OCAK (Hacettepe Üniversitesi) Ali ERKUL (Cumhuriyet Üniversitesi) Ali Kemal ÖZCAN (Tunceli Üniversitesi) Ali TAŞKIN (Cumhuriyet Üniversitesi) Arzu KARACA ÇAKINBERK (Tunceli Üniversitesi) Candan BADEM (Tunceli Üniversitesi) Cemal GÜZEL (Hacettepe Üniversitesi) Erdal YILDIRIM (Tunceli Üniversitesi) Faruk KOCACIK (C...

  7. Pravna ureditev izrednih prevozov v cestnem prometu za potrebe gradbeništva

    OpenAIRE

    Dragičevič, Sonja

    2013-01-01

    Namen diplomskega dela je bil celovito in na enem mestu zbrati pravno podlago, ki ureja postopke in načine izvedbe izrednih prevozov v cestnem prometu. Izredni prevozi so vedno bili zahtevni logistični procesi, ki od pripravljalca in izvajalca zahtevajo dodatne priprave za varen transport določene stvari (bodisi v tekočem bodisi trdem stanju) ali tovora, ki zaradi svoje oblike ali velikosti pogosto presega standarde obstoječe cestne zmogljivosti ali ki zaradi strupenosti, eksplozivnosti in po...

  8. Involvement of the p38 mitogen-activated protein kinase signal transduction pathway in burns-induced lung injury

    Institute of Scientific and Technical Information of China (English)

    CHEN Xu-lin; XIA Zhao-fan; WEI Duo; WANG Yong-jie; WANG Chang-rong

    2005-01-01

    @@ Acute lung injury (ALI) is a leading complication in extensively burned patients, especially those with inhalation injury.1 It can cause hypoxia resulting in injury of remote organs and dysfunction. P38 mitogen-activated protein kinase (p38 MAPK) is a stress activated protein kinase in the MAPK family.2 Most of the previous studies have demonstrated that p38 MAPK signal transduction pathway mediated ALI in rats with acute severe pancreatitis, sepsis etc.3-5 However, there is little information regarding the role of p38 MAPK signal transduction pathway in ALI after severe burn trauma.

  9. An improved heuristic for one-machine scheduling with delays constraints

    Institute of Scientific and Technical Information of China (English)

    杜东雷; 韩继业; 陈礴

    1997-01-01

    An improved heuristic is proposed for one-machine scheduling problem with delay constraints,thus an open problem raised by Wikum et al.is solved.The heuristic solves the corresponding unit-execution-time problem optimally.

  10. POZNAVANJE IN UPORABA CRM V SLOVENSKIH PODJETJIH PRI POSLOVANJU S TUJIMI PODJETJI

    OpenAIRE

    Kričej, Ana

    2011-01-01

    V diplomi je prestavljena teorija o CRM, strategija CRM in njena implementacija v podjetje. V zadnjem poglavju je analiza anketnega vprašalnika, ali podjetja poznajo in uporabljajo CRM pri poslovanju s tujimi podjetji.

  11. [Tänavuse Whitbreadi auhinna pälvis Hilary Spurling biograafia "Matisse the master" eest] / Lauri Eesmaa

    Index Scriptorium Estoniae

    Eesmaa, Lauri

    2006-01-01

    Romaanikategooria auhinna sai Ali Smith romaaniga "The accidental", luulekategoorias Christopher Logue luulekoguga "Cold calls", parima debüüdi tegi Tash Aw romaaniga "The harmony silk factory" ning lasteraamatu kategooria auhinna sai Kate Thompsoni teos "The new policeman"

  12. Linkage disequilibrium between incompatibility locus region genes in the plant Arabidopsis lyrata

    DEFF Research Database (Denmark)

    Hagenblad, Jenny; Bechsgaard, Jesper Smærup; Charlesworth, Deborah

    2006-01-01

    We have studied diversity in Arabidopsis lyrata of sequences orthologous to the ARK3 gene of A. thaliana. Our main goal was to test for recombination in the S-locus region. In A. thaliana, the single-copy ARK3 gene is closely linked to the non-functional copies of the self-incompatibility loci, and...... the ortholog in A. lyrata (a self-incompatible species) is in the homologous genome region and is known as Aly8. It is thus of interest to test whether Aly8 sequence diversity is elevated due to close linkage to the highly polymorphic incompatibility locus, as is theoretically predicted. However, Aly8...... linked to the incompatibility locus, one being a pseudogene. We determined the phase of multiple haplotypes in families of plants from Icelandic and other populations. Different Aly8 sequence types are associated with different SRK alleles, while haplotypes with the same SRK sequences tend to have the...

  13. Anti-inflammatory effects of eugenol on lipopolysaccharide-induced inflammatory reaction in acute lung injury via regulating inflammation and redox status.

    Science.gov (United States)

    Huang, Xianfeng; Liu, Yuanyuan; Lu, Yingxun; Ma, Chunhua

    2015-05-01

    Acute lung injury (ALI) represents a clinical syndrome that results from complex responses of the lung to a multitude of direct and indirect insults. This study aims to evaluate the possible mechanisms responsible for the anti-inflammatory effects of eugenol (EUL) on lipopolysaccharide (LPS)-induced inflammatory reaction in ALI. ALI was induced in mice by intratracheal instillation of LPS (0.5 mg/kg), and EUL (5, and 10 mg/kg) was injected intraperitoneally 1h prior to LPS administration. After 6h, bronchoalveolar lavage fluid (BALF) and lung tissue were collected. The findings suggest that the protective mechanism of EUL may be attributed partly to decreased production of proinflammatory cytokines through the regulating inflammation and redox status. The results support that use of EUL is beneficial in the treatment of ALI.

  14. Assembly line balancing problem: Comparison of some heuristic procedures

    OpenAIRE

    Mete, Hasan Ali

    1989-01-01

    Ankara : The Department of Management and the Graduate School of Business Administration of Bilkent Univ. , 1989. Thesis (Master's) -- Bilkent University, 1989. Includes bibliographical references leaves 56-58. Mete, Hasan Ali Master's

  15. TAKIM ANALYZY

    OpenAIRE

    ERDEM, Orhan; Polat, Sedat

    2010-01-01

    Bu makale takym olu?um sürecini ve takym olu?um a?amalaryndaki takym üyelerini, takym ruhunu, ileti?imi, çaty?ma ve çaty?ma yönetimini ve teknolojinin etkisini tahlil etmektedir. Bu makale özetle takym içinde takym olu?um süreçleri olan "olu?ma, aly?ma, kuralla?ma ve çaly?ma" basamaklarynda ya?ananlary tespit etmektedir. Bu çaly?ma ?u sorulara cevap bulmaktadyr: Takym olu?um a?amalarynyn herbirinde ne kadar zaman harcanmaktadyr? Takymda ne gibi bir olu?um vardyr? Bu çaly?man...

  16. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... being in band, and I had a part-time job at Staples and was very involved in ... soreness and pain for an extended period of time, Aly was diagnosed with Juvenile Arthritis. Despite receiving ...

  17. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... in band, and I had a part-time job at Staples and was very involved in my ... class was a major frustration and a major loss for her,” she added. Although Aly was initially ...

  18. 76 FR 37094 - List of Correspondence

    Science.gov (United States)

    2011-06-24

    ... May Be of Interest to Readers Topic Addressed: Harassment And Bullying. Dear Colleague Letter dated October 26, 2010 from Office for Civil Rights Assistant Secretary Russlynn Ali, regarding bullying...

  19. PODPORA MOBILNEGA POSLOVANJA S CELOVITIMI INFORMACIJSKIMI REŠITVAMI

    OpenAIRE

    Kos, Gašper

    2013-01-01

    Mobilno poslovanje je podjetjem dodalo nove dimenzije. Vso poslovanje je sedaj na dosego mobilnega telefona ali tabličnega računalnika. To tudi predstavlja konkurenčno prednost podjetij, ki izvajajo m-poslovanje.

  20. Engineering professor achieves two prestigious professional milestones

    OpenAIRE

    Gilbert, Karen

    2005-01-01

    Ali Nayfeh of Blacksburg, University Distinguished Professor in the Department of Engineering Science and Mechanics in the College of Engineering at Virginia Tech, recently achieved two prestigious professional milestones.

  1. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... Clinicians For Policymakers For Family Caregivers Menu In this section RESOURCES Links News Videos, Podcasts & Livechats For ... is simple: to live the best life possible. This is her palliative care story. Aly has always ...

  2. AcEST: DK961874 [AcEST

    Lifescience Database Archive (English)

    Full Text Available sp|A8MBU4|NPD_CALMQ NAD-dependent deacetylase OS=Caldivirga maquilingensis (strain DSMZ 13496 / IC-167) Ali...MQ NAD-dependent deacetylase OS=Caldivirga maquilingensis (strain DSMZ 13496 / IC

  3. 2 October 2012 - Egyptian Academy of Scientific Research and Technology President M. Al Sherbiny signing a protocol agreement with CERN Director-General R. Heuer, witnessed by Ambassador to the UN W. Bassim. This signature is followed by the signature of an MoU with ALICE and CMS Collaborations.

    CERN Document Server

    Maximilien Brice

    2012-01-01

    Where present: ALICE Collaboration: CP. Giubellino, F. Carminati, C. Decosse, and A. N. Tawfik CMS Collaboration: T. Camporesi A. Charkiewicz, A. De Roeck, A. Petrilli, A. Sharma with S. Aly, Y. Assran, M. Attia, R. Masod and A. Radi

  4. Filme kaladest : "Maelströmi" külm langemine, "Bo Ba Bu" kiviaegne röhkimine ja vanameister Imamura "Soe vesi punase silla all" / Erkki Luuk

    Index Scriptorium Estoniae

    Luuk, Erkki, 1971-

    2001-01-01

    Temaatiliselt koos vaadeldakse kolme erineva kultuuritaustaga režissööri filme : kanadalase Denis Villeneuve "Maelström", usbeki Ali Hamrajevi "Bo Ba Bu" ja jaapanlase Shohei Imamura "Soe vesi punase silla all"

  5. Gene : CBRC-MMUS-11-0132 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available ERASE) (MONOBUTYRASE) (COCAINE ESTERASE) (PROCAINE ESTERASE) (METHYLBUTYRASE) ......d library, clone:A430088E12 product:similar to CARBOXYLESTERASE PRECURSOR (EC 3.1.1.1) (ALI-ESTERASE) (B-EST

  6. A new species of Begonia L.(Begoniaceae) from Yunnan, Chinas Y. Y. Qian; New species; China%云南秋海棠属一新种

    Institute of Scientific and Technical Information of China (English)

    钱义咏

    2001-01-01

    @@ Begonia menglianensis Y. Y. Qian, sp. nov. (Sect. Platycentrum Ser. Cathayanae). Fig. 1 Habitu B. versicolori lrmsch. similis, sed foliorum laminis supra glabris, florum staminatorum tepalis 4, capsularum alis majoribus ligulatis, 20~22 mm longis differt.

  7. Disease: H01301 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ncodes tight-junction protein causes this syndrome. Nervous system disease hsa045...vich AJ, Ali B, Al-Gazali L, Walsh CA A homozygous mutation in the tight-junction protein JAM3 causes

  8. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... three-year-old Aly Becker lives with the symptoms of multiple diagnoses including Churg Strauss syndrome and ... diagnosed with Juvenile Arthritis. Despite receiving treatment, her symptoms worsened. She began to lose significant weight and ...

  9. Plaadid / Margus Kiis

    Index Scriptorium Estoniae

    Kiis, Margus

    2002-01-01

    Uutest plaatidest Nightlight Dou "La Fiesta Del Sol", Yves Montand "Ses Plus Grands Succes", Natalia Oreiro "Tu veneno", Daishin Kashimoto "Passionata", Mike Oldfield "Tres Lunas", Ali G Indiahouse "Da Soundtrack", Ronan Keating "Destination", Roger Waters "Flickering Flame"

  10. Simulatsioon, situatsioon, kaos / Rain Tolk

    Index Scriptorium Estoniae

    Tolk, Rain, 1977-

    2004-01-01

    Provokatiivse teleprogrammi "Ekskursioon" (Kanal 2) võrdlus ameerika ja inglise analoogidega - "Da Ali G Show" ja "The Awful Truth & TV-Nation". Lisatud Kanal 2 programmijuhi Olle Mirme kommentaar ja "Provokatiivseid saateid ja momente eesti teleajaloos" lk. 126

  11. Zaposlovanje tujcev v Republiki Sloveniji

    OpenAIRE

    Manoleva, Nada

    2010-01-01

    Zaradi vse večjega staranja prebivalstva in zmanjševanja naravnega prirastka se povečuje povpraševanje po tuji delovni sili. Postopek zaposlovanja je odvisen od tega, ali tujec prihaja iz držav članic EU, EGP in Švicarske konfederacije ali pa iz t.i. tretjih držav. Za vse zaposlene delavce v Sloveniji ne glede na to, ali so slovenski državljani, državljani držav članic EU, EGP in Švicarske konfederacije ali pa državljani tretjih držav, velja, da so glede plače ter drugih delovnih pogojev p...

  12. 新生儿急性肺损伤

    Institute of Scientific and Technical Information of China (English)

    蔡栩栩; 韩玉昆

    2003-01-01

    @@ 20世纪90年代,人们对急性呼吸窘迫综合征(ARDS)的认识逐步深化,提出了急性肺损伤( ALI)的概念,认为ALI与ARDS同属于一个病理生理过程,ARDS是ALI发展的严重阶段,并认识到ALI/ARDS是全身炎症反应综合征(SIRS)在肺部的表现,是致炎和抗炎之间平衡失调的结果.但有关新生儿ALI/ARDS的研究起步较晚,本文就近年来有关新生儿ALI/ARDS的临床和基础研究加以综述.

  13. В российских СМИ начались чистки / Ксения Репсон

    Index Scriptorium Estoniae

    Репсон, Ксения

    2011-01-01

    Venemaa oligarh Ališer Usmanov vallandas ASi Kommersant Holding peadirektori Andrei Galijevi ja ajakirja Kommersant-Vlast peatoimetaja Maksim Kovalski, tuues põhjuseks Venemaa peaministri Vladimir Putini solvamise

  14. Vene oligarh vallandas meediajuhte / Ksenia Repson

    Index Scriptorium Estoniae

    Repson, Ksenia

    2011-01-01

    Venemaa oligarh Ališer Usmanov vallandas ASi Kommersant Holding peadirektori Andrei Galijevi ja ajakirja Kommersant-Vlast peatoimetaja Maksim Kovalski, tuues põhjuseks Venemaa peaministri Vladimir Putini solvamise

  15. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... Quiz Videos, Podcasts and Livechats Living Well with Serious Illness: Aly’s Palliative Care Story August, 2016 Navigating ... anyone. Imagine spending those pivotal years with a serious illness. Twenty-three-year-old Aly Becker lives ...

  16. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... Livechats Living Well with Serious Illness: Aly’s Palliative Care Story August, 2016 Navigating the uncertain waters of ... the best life possible. This is her palliative care story. Aly has always been the type to ...

  17. Forschungsschwerpunkte im Institut für Kulturgeographie der Universität Frankfurt am Main am Ende der 80er Jahre

    Directory of Open Access Journals (Sweden)

    Klaus Wolf

    1987-12-01

    Full Text Available The review of research work of the Institute exposes the spheres of tourism population development and sub-urbanisation with ali accompanying economic and non-economic phenomena.

  18. Rural Health Information Hub

    Science.gov (United States)

    ... be the best treatment. Exploring High Infant and Maternal Mortality Rates in the Rural U.S. with Dr. Ali ... reasons behind the United States’ high infant and maternal mortality rates. A Professor of Global Health at the ...

  19. EVTANAZIJA MED RELIGIJO IN PRAVOM

    OpenAIRE

    Bajrektarević, Selim

    2012-01-01

    Evtanazija? Dostojanstvena smrt ali odvzem življenja, pomoč v življenjski stiski ali kaznivo dejanje. Večna dilema, ki jo najdemo na vseh stopnjah družbenega življenja. V medicini, kjer zdravniki bijejo bitko sami s sabo, ali naj umirajočemu skrajšajo bolečine ali podaljšajo neizogibno. V pravu, kjer zakonodaja na vse načine poskuša s pravili evtanazijo zadržati pod kontrolo, jo legalizirati, vendar vedno naletijo na težave zlorabe teh pravil, zaradi katerih je dilema še večja. Tu je tudi pod...

  20. 77 FR 39573 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Science.gov (United States)

    2012-07-03

    ... to the Kingpin Act: SALEH, Ali Mohamad, c/o ALMACEN BATUL; c/o COMERCIAL ESTILO Y MODA; DOB 1 Jan... To: COMERCIAL ESTILO Y MODA. Dated: June 27, 2012. Adam J. Szubin, Director, Office of Foreign...

  1. 77 FR 60022 - Supplemental Identification Information for One (1) Individual Designated Pursuant to Executive...

    Science.gov (United States)

    2012-10-01

    ..., or economy of the United States; (3) persons determined by the Director of OFAC, in consultation with.... JUMALI, Ahmed Ali), P.O. Box 3312, Dubai, United Arab Emirates; Mogadishu, Somalia; Djibouti,...

  2. 3Corners of the World / Joosep Sang

    Index Scriptorium Estoniae

    Sang, Joosep

    2009-01-01

    Arvustused : Robert Jürjendal, Petri Kuljuntausta, David Rothenberg. 3Corners of the World. [Tallinn] : Terra Nova Music, 2008. Nadia ja Fragile. Uhke ali. [Tallinn] : Nadia & Fragile, 2008. UMA. Civitas Soli. [Tallinn] : Elwood, 2008. Uutest heliplaatidest

  3. Nucleotide sequence of the coat protein genes of alstroemeria mosaic virus and amazon lily mosaic virus, a tentative species of genus potyvirus.

    Science.gov (United States)

    Fuji, S; Terami, F; Furuya, H; Naito, H; Fukumoto, F

    2004-09-01

    The nucleotide sequences of the 3' terminal region of the genomes of Alstroemeria mosaic virus (AlsMV) and the Amazon lily mosaic virus (ALiMV) have been determined. These sequences contain the complete coding region of the viral coat protein (CP) gene followed by a 3'-untranslated region (3'-UTR). AlsMV and ALiMV share 74.9% identity in the amino acid sequence of the CP, and 55.6% identity in the nucleotide sequence of the 3'-UTR. Phylogenetic analysis of these CP genes and 3'-UTRs in relation to those of 79 potyvirus species revealed that AlsMV and ALiMV should be assigned to the Potato virus Y (PVY) subgroup. AlsMV and ALiMV were concluded to have arisen independently within the PVY subgroup. PMID:15593424

  4. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... those pivotal years with a serious illness. Twenty-three-year-old Aly Becker lives with the symptoms ... Valerie Wallace, a young, vibrant, upbeat mother of three diagnosed with colorectal cancer that spread to her ...

  5. ALICE-ARC integration

    DEFF Research Database (Denmark)

    Anderlik, Csaba; Gregersen, Anders Rhod; Kleist, Josva;

    2008-01-01

    Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The interoperation has two aspects, one is the data......AliEn or Alice Environment is the Gridware developed and used within the ALICE collaboration for storing and processing data in a distributed manner. ARC (Advanced Resource Connector) is the Grid middleware deployed across the Nordic countries and gluing together the resources within the Nordic...... management part and the second the job management aspect. The first aspect was solved by using dCache across NDGF to handle data. dCache provides support for several data management tools (among them for xrootd the tools used by AliEn) using the so called "doors". Therefore, we will concentrate on the second...

  6. ALICE - ARC integration

    DEFF Research Database (Denmark)

    Anderlik, Csaba; Gregersen, Anders Rhod; Kleist, Josva;

    Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The interoperation has two aspects, one is the data......AliEn or Alice Environment is the Gridware developed and used within the ALICE collaboration for storing and processing data in a distributed manner. ARC (Advanced Resource Connector) is the Grid middleware deployed across the Nordic countries and gluing together the resources within the Nordic...... management part and the second the job management aspect. The first aspect was solved by using dCache across NDGF to handle data. dCache provides support for several data management tools (among them for xrootd the tools used by AliEn) using the so called "doors". Therefore, we will concentrate on the second...

  7. BREZKRTAČNI MOTORJI ZA ELEKTRIČNA KOLESA

    OpenAIRE

    Flis, Marko

    2014-01-01

    Diplomsko delo obravnava brezkrtačne motorje za električna dvokolesna vozila. Električna dvokolesna vozila niso samo ekološka in varčna, temveč so izreden pripomoček ljudem, ki imajo kakršnokoli motnjo ali težavo pri premikanju ali hoji. Zlasti starejši ljudje kmalu po nastanku težav opustijo uporabo kolesa pretežno zaradi težav premagovanja klančin, ko noge ne »zdržijo« več, ali pa se lahko zgodi, da nastopi nenadna utrujenost ali dihalne težave. Glavni del električnega kolesa predstavlja el...

  8. Berliini biennal : teater ühel tänaval : biennaalikunst / Rael Artel

    Index Scriptorium Estoniae

    Artel, Rael, 1980-

    2006-01-01

    IV Berliini kaasaegse kunsti biennaal "Of Mice and Men / Hiirtest ja inimestest" Berliinis Auguststrasse ümbruses kuni 28. V. Kuraatorid Maurizio Cattelan, Massimiliano Gioni ja Ali Subotnick. Väljapanekust, toimumiskohast

  9. Dicty_cDB: VSD225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available skitlvlcviqkvkskvtfsdq sprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---VYINNVKSTSRR**lqsi...*lsdkentgrermvftsiskitlvlcviqkvkskvtfsdq sprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---...iqkvkskvtf sdqsprnapiygqrlppmpvplfk*ihiklkq Homology vs CSM-cDNA Score E Sequences producing significant ali

  10. Dicty_cDB: VSD437 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available slpskvskvv*idyhpqvlviw swlpskrvnqn*erkfalv*lsdkentgrermvftsiskitlvlcviqkvkskvtfsdqs prnapiygqrlppmpvplfk*IHI...ermvftsiskitlvlcviqkvkskvtfsdqs prnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---hk*cqkhkps...iyfednagvmcnpkgevkgnilg pvakecsdlgqrlppmpvp Homology vs CSM-cDNA Score E Sequences producing significant ali

  11. Disease: H01070 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H01070 Vibrio furnissii infection Vibrio furnissii, first described as a gasproducing biovar of Vibrio fluvi...alis, is associated with human acute gastroenteritis. The pathology of V. furnissii

  12. On Certain Classes of Biharmonic Mappings Defined by Convolution

    Directory of Open Access Journals (Sweden)

    J. Chen

    2012-01-01

    Full Text Available We introduce a class of complex-valued biharmonic mappings, denoted by , together with its subclass , and then generalize the discussions in Ali et al. (2010 to the setting of and in a unified way.

  13. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... possible. This is her palliative care story. Aly has always been the type to want to do ... her degree. Becoming an advocate for palliative care has also been an exciting new venture. “I had ...

  14. Faculty bestowed IBM Faculty Awards

    OpenAIRE

    Daniilidi, Christina

    2009-01-01

    Wu Feng of the computer science and electrical and computer engineering departments in Virginia Tech's College of Engineering, and Ali Butt, also of the computer science department, were recently named as recipients of IBM Faculty Awards.

  15. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... period of time, Aly was diagnosed with Juvenile Arthritis. Despite receiving treatment, her symptoms worsened. She began ... a multitude of illnesses, including lupus and rheumatoid arthritis. As her symptoms worsened, her quality of life ...

  16. Protective Effect of Rhubarb on Endotoxin-Induced Acute Lung Injury

    Institute of Scientific and Technical Information of China (English)

    李春盛; 周景; 桂培春; 何新华

    2001-01-01

    To approach the mechanism of lipopolysaccharide (LPS) in causing acute lung injury (ALI) and the protective effect of rhubarb and dexamethasone, lung specimens were examined with macroscopy, microscopy, electron microscopy and the biological markers of ALI including lung wet/dry weight, the rate of neutrophils and protein content in the pulmonary alveolar lavage fluid, pulmonary capillary permeability and pulmonary alveolar permeability index were observed. The mechanism of the ALI is mainly due to direct injury of alveolar epithelium and pulmonary vascular endothelium. Rhubarb and dexamethasone could significantly reduce the edema of the lung tissue, decrease the red blood cell exudation, neutrophil infiltration and plasma protein exudation in the alveoli and all the biological markers in comparison with the ALI model rats, indicating they have protective action on vascular endothelium and alveolar epithelium.

  17. Pommipanija vabastamine tekitab tõsiseid pingeid / Tiina Tamman

    Index Scriptorium Estoniae

    Tamman, Tiina, 1948-

    2009-01-01

    Lockerbié lennukatastroofi korraldamise eest vangi mõistetud Abdul Baset Ali al-Megrahi vabastamine Šotimaal on USA-s kaasa toonud proteste. Suurbritannia kinnitusel Šotimaale otsuse tegemisel survet ei avaldatud

  18. Põhjapanevad uuendused Brunei naftasultanaadis / Allan Espenberg

    Index Scriptorium Estoniae

    Espenberg, Allan

    2004-01-01

    Parlamenti ehk Seadusandlikku Kogu pole Bruneis eksisteerinud 42 aastat, sest 1962. a. saatis valitseja Omar Ali Saifuddin selle laiali. 25. sept. tuli 21-liikmeline parlament kokku. Bruneist kui heaolu riigist

  19. Bakuus vaikne võimuvahetus / Tõnis Arnover

    Index Scriptorium Estoniae

    Arnover, Tõnis, 1952-

    2003-01-01

    Aserbaidžaanis läks võim kauaaegselt liidrilt Heidar Alijevilt poeg Ilhamile, kellelt oodatakse sõjalise konflikti lahendamist Mägi-Karabahhias ning majandusreformide jätkamist. Lisa: Heidar Ali-oglu Alijev

  20. Screening for Dysglycemia: Connecting Supply and Demand to Slow Growth in Diabetes Incidence.

    Directory of Open Access Journals (Sweden)

    Mohammed K Ali

    2016-07-01

    Full Text Available Mohammed Ali and Venkat Narayan describe the challenge of implementing evidence-based interventions for prevention for the large number of people at increased risk of type 2 diabetes.

  1. Videos, Podcasts and Livechats

    Medline Plus

    Full Text Available ... addition to providing support for the depression and anxiety that stemmed from her illness, the team helped Aly find additional outlets for her stress. She began seeing the team’s chaplain to discuss ...

  2. Belgia kunstikoguja segab Kuressaaret kunstiafääri / Taavi Tuisk

    Index Scriptorium Estoniae

    Tuisk, Taavi

    2008-01-01

    Mehhikos elav belglane Francis Alys (1959) süüdistab 1997. a. Saaremaa biennaali korraldajaid temale kuulunud ja biennaalil eksponeeritud tööde (Jean-Jacques Henner' maali koopiad) äravahetamises

  3. Relationship between the expression of Toll-like receptor 2 and 4 in mononuclear cells and postoperative acute lung injury in orthotopic liver transplantation

    Institute of Scientific and Technical Information of China (English)

    CHI Xin-jin; CAI Jun; LUO Chen-fang; CHENG Nan; HEI Zi-qing; LI Shang-rong; LUO Gang-jian

    2009-01-01

    Background The aim of this study was to investigate the potential relationship between the dynamic expression of Toll-like receptor 2 and 4 (TLR2/4) in peripheral blood mononuclear cells as well as changes in serum concentration of inflammatory factors and acute lung injury (ALl) in patients after orthotopic liver transplantation (OLT).Methods The peripheral blood samples of 27 patients (23 men and 4 women with ASA Ⅲ to Ⅳ) who received OLT were collected for measurement of TLR2/4 at T1 (after induction of anesthesia), T2 (25 minutes after anhepatic phase), T3 (3 hours after graft reperfusion) and T4 (24 hours after graft reperfusion). The expression of TLR2/4 in mononuclear cells was measured by flow cytometry. The serum concentrations of tumor necrosis factor (TNF)-a, intedeukin (IL)-113 and IL-8 were measured by enzyme-linked irnmunosorbent assay (ELISA). Twenty-seven patients were assigned to ALI group (n=9) and non-ALI group (n=18) according to the diagnostic criteria of ALI. The expression of TLR2/4 in the ALl group or non-ALI group was analyzed.Results Compared to the non-ALI group, the volumes of blood loss, ascites, total output and transfused red blood cells were higher in the ALI group, and the anhepallc phase lasted longer (P0.05). The expression of TLR2/4 in mononuclear cells increased significantly at T3 and 14 in the ALI group (P<0.05, P<0.01). A positive correlation was noted between the expression of TLR4 in mononuclear cells and the serum concentrations of TNF-α, IL-1β (P=0.041, P=0.046) in the ALl group. In the non-ALI group, statistical results showed that the expression level of TLR2/4 in mononuclear cells was not significantly different during the peri-operative period of OLT (besides TLR4 expression at T4). Compared to the non-ALI group, the increasing amplitude of TLR2/4 expression in mononuclear cells was more significant in the ALI group. The patients whose TLR2/4 expression in mononuclear cells exceeded that at T1 by one time were

  4. Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.

    Directory of Open Access Journals (Sweden)

    Shunying Jin

    Full Text Available Immune-complexes play an important role in the inflammatory diseases of the lung. Neutrophil activation mediates immune-complex (IC deposition-induced acute lung injury (ALI. Components of gamma amino butyric acid (GABA signaling, including GABA B receptor 2 (GABABR2, GAD65/67 and the GABA transporter, are present in the lungs and in the neutrophils. However, the role of pulmonary GABABR activation in the context of neutrophil-mediated ALI has not been determined. Thus, the objective of the current study was to determine whether administration of a GABABR agonist, baclofen would ameliorate or exacerbate ALI. We hypothesized that baclofen would regulate IC-induced ALI by preserving pulmonary GABABR expression. Rats were subjected to sham injury or IC-induced ALI and two hours later rats were treated intratracheally with saline or 1 mg/kg baclofen for 2 additional hours and sacrificed. ALI was assessed by vascular leakage, histology, TUNEL, and lung caspase-3 cleavage. ALI increased total protein, tumor necrosis factor α (TNF-α and interleukin-1 receptor associated protein (IL-1R AcP, in the bronchoalveolar lavage fluid (BALF. Moreover, ALI decreased lung GABABR2 expression, increased phospho-p38 MAPK, promoted IκB degradation and increased neutrophil influx in the lung. Administration of baclofen, after initiation of ALI, restored GABABR expression, which was inhibited in the presence of a GABABR antagonist, CGP52432. Baclofen administration activated pulmonary phospho-ERK and inhibited p38 MAPK phosphorylation and IκB degradation. Additionally, baclofen significantly inhibited pro-inflammatory TNF-α and IL-1βAcP release and promoted BAL neutrophil apoptosis. Protective effects of baclofen treatment on ALI were possibly mediated by inhibition of TNF-α- and IL-1β-mediated inflammatory signaling. Interestingly, GABABR2 expression was regulated in the type II pneumocytes in lung tissue sections from lung injured patients, further suggesting

  5. Adult Stem Cells for Acute Lung Injury: Remaining Questions & Concerns

    OpenAIRE

    Zhu, Ying-Gang; Hao, Qi; Monsel, Antoine; Feng, Xiao-mei; Lee, Jae W.

    2013-01-01

    Acute lung injury (ALI) or acute respiratory distress syndrome remains a major cause of morbidity and mortality in hospitalized patients. The pathophysiology of ALI involves complex interactions between the inciting event, such as pneumonia, sepsis or aspiration, and the host immune response resulting in lung protein permeability, impaired resolution of pulmonary edema, an intense inflammatory response in the injured alveolus and hypoxemia. In multiple pre-clinical studies, adult stem cells h...

  6. Traditional Chinese medicine, Qing Ying Tang, ameliorates the severity of acute lung injury induced by severe acute pancreatitis in rats via the upregulation of aquaporin-1

    OpenAIRE

    GAO, ZHENMING; Xu, Junfeng; Sun, Deguang; ZHANG, Rixin; LIANG, RUI; Wang, Liming; Fan, Rong

    2014-01-01

    Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role in a number of edema-associated lung diseases. Qing Yin Tang (QYT), a traditional Chinese medicine, has been shown to effectively reduce the mortality rate of acute lung injury (ALI) induced by severe acute pancreatitis (SAP). The current study aimed to investigate the detailed mechanisms underlying the effects of QYT on ALI induced by SAP, particularly the effects on ...

  7. Lithium abundances in high- and low-alpha halo stars

    DEFF Research Database (Denmark)

    Nissen, P. E.; Schuster, W. J.

    2012-01-01

    is well fitted by a relation A(Li) = a0 + a1 M + a2 Z + a3 M Z, where a0, a1, a2, and a3 are constants. Extrapolating this relation to Z = 0 leads to A(Li)= 2.58 ± 0.08 close to the primordial Li abundance predicted from standard Big Bang nucleosynthesis calculations and the WMAP baryon density. A...

  8. Recurrent Arterial Thrombosis as a Presenting Feature of a Variant M3-Acute Promyelocytic Leukemia

    OpenAIRE

    Chotai, Pranit N.; Kasangana, Kalenda; Abhinav B. Chandra; Atul S Rao

    2016-01-01

    Acute limb ischemia (ALI) is a common vascular emergency. Hematologic malignancies are commonly associated with derangement of normal hemostasis and thrombo-hemorrhagic symptoms during the course of the disease are common. However, ALI as an initial presenting feature of acute leukemia is rare. Due to the rarity of this presentation, there is a scarcity of prospective randomized data to optimally guide the management of these patients. Current knowledge is mainly based on isolated cases. We r...

  9. Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients

    OpenAIRE

    Slutsky Arthur S; Zhang Haibo; Haitsma Jack J; Royakkers Annick ANM; Determann Rogier M; Ranieri V Marco; Schultz Marcus J

    2010-01-01

    Abstract Background Preventing ventilator-associated lung injury (VALI) has become pivotal in mechanical ventilation of patients with acute lung injury (ALI) or its more severe form, acute respiratory distress syndrome (ARDS). In the present study we investigated whether plasma levels of lung-specific biological markers can be used to evaluate lung injury in patients with ALI/ARDS and patients without lung injury at onset of mechanical ventilation. Methods Plasma levels of surfactant protein ...

  10. Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

    OpenAIRE

    Koeppen, Michael; Eckle, Tobias; Eltzschig, Holger K.

    2011-01-01

    Murine models are extensively used to investigate acute injuries of different organs systems (1-34). Acute lung injury (ALI), which occurs with prolonged mechanical ventilation, contributes to morbidity and mortality of critical illness, and studies on novel genetic or pharmacological targets are areas of intense investigation (1-3, 5, 8, 26, 30, 33-36). ALI is defined by the acute onset of the disease, which leads to non-cardiac pulmonary edema and subsequent impairment of pulmonary gas exch...

  11. Heat Shock Protein 90 Inhibitors Prolong Survival, Attenuate Inflammation, and Reduce Lung Injury in Murine Sepsis

    OpenAIRE

    Chatterjee, Anuran; Dimitropoulou, Christiana; Drakopanayiotakis, Fotios; ANTONOVA, Galina; Snead, Connie; Cannon, Joseph; Venema, Richard C.; Catravas, John D.

    2007-01-01

    Rationale: Severe sepsis is the leading cause of death for patients in intensive care units. Patients with severe sepsis develop multiple organ failure, including acute lung injury (ALI), resulting from a deregulated inflammatory response. Inhibitors of the ubiquitous chaperone, heat shock protein 90 (Hsp90), block the activity of certain proinflammatory mediators in vitro. We hypothesized that Hsp90 inhibitors may ameliorate the inflammation and ALI associated with severe sepsis.

  12. On the link between the Bonferroni index and the measurement of inclusive growth.

    OpenAIRE

    Jacques Silber; Hyun Son

    2010-01-01

    In a recent paper Ali and Son (2007) suggested measuring the concept of "inclusive growth" via the use of what they called a "social opportunity function". The latter was assumed to depend on the average opportunities available in the population and to give greater weight to the opportunities enjoyed by the poor. On the basis of this approach Ali and Son (2007) then defined an "opportunity index" and an "opportunity curve". The present paper derives the link which exists between these concept...

  13. Detection of Bay of Bengal eddies from TOPEX and in situ observations

    Digital Repository Service at National Institute of Oceanography (India)

    Gopalan, A.K.S.; Gopalakrishna, V.V.; Ali; Sharma, R.

    BayofBengaleddiesfromTOPEXandinsituobservations byA.K.S.Gopalan 1,V.V.GopalaKrishna 2,M.M.Ali1andRashmiSharma 1ABSTRACT Oceaniceddieshavewarmorcoldtemperaturesandhighorlowseasurfaceheight(SSH)atthecenterdependinguponthedirectionofrotation.However,sincetheBayofBengalwatersarehighlystratibullet5ed.../cycloniceddies,waterconverges/divergesatthecenteroftheeddyduringtheformationprocessresultingindownward/upwardmotionofwater.Henceverticalthermalsectionsshowtrough/ridgeintheisothermalpatterns. Informationoneddiesisrequiredinmanyoceanicandatmosphericstudieslikeacousticpropagation,optimumshiprouteplanning,bullet5shery,delineatinggood/badmonsoonyears(Dubeetal.,190),heattransport,etc.Eddiescanbestudiedindetailusingremotesensors inthemicrowaveregionliketheradaraltimeter,syntheticapertureradar,andthoseoperatingininfraredandvisibleregions.Scatterometerwindsalsocanbeusedthroughoceancirculationmodels.Ali...

  14. Arsenic enrichment in estuarine sediments-impact of iron and manganese mining

    Digital Repository Service at National Institute of Oceanography (India)

    Nair, M.; Joseph, T.; Balachandran, K.K.; Nair, K.K.C.; Paimpillii, J.S.

    , Tokyo, Japan with assistance from ITN Centre, Bangladesh. Edited by: M. Feroze Ahmed Ph.D. Professor Department of Civil Engineering, SUET, Dhaka-1000, Bangladesh, M. Ashraf Ali Ph.D. AssociateProfes~or Department of Civil Engineering, BUET, Dhaka-1000... Enrichment in Estuarine Sediments 57 Arsenic Enrichment in Estuarine Sediments - Impact of Iron and Manganese Mining Maheswari Nair, T. Joseph, K.K. Balachandran, K.K.C.Nair Regional Center, National Institute of Oceanography, Salim Ali Road, eochin 14, India...

  15. Seafloor spreading magnetic anomalies in the southeastern Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Chaubey, A.K.; Bhattacharya, G.C.; Rao, D.G.

    28 or anom- aly 27) when the spreading centre jumped between India and Seychelles. This phase of spreading possibly ceased or became very slow sometime after the formation of anomaly 21. The spreading of the later phase commenced in its present... in our study area. Schlich (1975) recognized the existence of a brief normal polarity interval within these two relatively long normal polarity intervals of anom- aly 24. This interval was included as the third subchron (24N2) in the recent...

  16. What drives nearshore sediment transport controls on the depletion of beach placers at Manavalakurichi, Southwest Coast of India?.

    Digital Repository Service at National Institute of Oceanography (India)

    DineshKumar, P.K.; ManiMurali, R.; Babu, M.T.; Sudheesh, K.; Vethamony, P.; NaveenKumar, K.R.

    7000 km, large deposits of beach sand minerals have been reported at selected locations in the coastal stretches of peninsular India (Ali, Krishnan, &Banerjee, 2001; AMD, 2000; Ashwathanarayana, 1964; GSI, 1976; Gujar, 1996; Hashimi, Kidwai, & Nair..., this deposit has been extensively exploited commercially for important minerals, such asilmenite, rutile, garnet, and monazite (Ali, Krishnan, & Banerjee, 2001; Vivekandan, 2005). Over the decades, it has been observed that the quantity of heavy minerals...

  17. Can words be read without abstract letter identities?

    OpenAIRE

    Simon Fischer-Baum

    2014-01-01

    Most theories of reading and writing posit a level of representation that codes abstract letter identities (ALIs) independent of the font, case, and even modality in which the letter was presented or produced (e.g., Caramazza & Hillis, 1990). Most cognitive theories assume that ALIs are critical for mediating between peripheral (e.g., processing visual shapes, executing motor plans) and central (e.g., accessing semantic or lexical information) written language processes. We present a case stu...

  18. Involvement of NF-ΚB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens

    OpenAIRE

    Ibrahim, Mohamed Yousif

    2014-01-01

    Mohamed Yousif Ibrahim,1 Najihah Mohd Hashim,1 Syam Mohan,2 Mahmood Ameen Abdulla,3 Siddig Ibrahim Abdelwahab,2 Behnam Kamalidehghan,1 Mostafa Ghaderian,1,4 Firouzeh Dehghan,1,5 Landa Zeenelabdin Ali,1 Hamed Karimian,1 Maizatulakmal Yahayu,6 Gwendoline Cheng Lian Ee,7 Abdoreza Soleimani Farjam,8 Hapipah Mohd Ali9 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Medical Research Centre, Jazan University, Jazan, Saudi Arabia; 3Department of Molecular ...

  19. Spred-2 Deficiency Exacerbates Lipopolysaccharide-Induced Acute Lung Inflammation in Mice

    OpenAIRE

    Yang Xu; Toshihiro Ito; Soichiro Fushimi; Sakuma Takahashi; Junya Itakura; Ryojiro Kimura; Miwa Sato; Megumi Mino; Akihiko Yoshimura; Akihiro Matsukawa

    2014-01-01

    BACKGROUND: Acute respiratory distress syndrome (ARDS) is a severe and life-threatening acute lung injury (ALI) that is caused by noxious stimuli and pathogens. ALI is characterized by marked acute inflammation with elevated alveolar cytokine levels. Mitogen-activated protein kinase (MAPK) pathways are involved in cytokine production, but the mechanisms that regulate these pathways remain poorly characterized. Here, we focused on the role of Sprouty-related EVH1-domain-containing protein (Spr...

  20. The molecular fingerprint of lung inflammation after blunt chest trauma

    OpenAIRE

    Ehrnthaller, Christian; Flierl, Michael; Perl, Mario; Denk, Stephanie; Unnewehr, Heike; Ward, Peter A.; Radermacher, Peter; Ignatius, Anita; Gebhard, Florian; Chinnaiyan, Arul; Huber-Lang, Markus

    2015-01-01

    Background After severe blunt chest trauma, the development of an acute lung injury (ALI) is often associated with severe or even lethal complications. Especially in multiple injured patients after blunt chest trauma ALI/ARDS [acute respiratory distress syndrome (ARDS)] is frequent. However, in the initial posttraumatic phase, inflammatory clinical signs are often not apparent and underlying changes in gene-expression profile are unknown. Methods Therefore, inflammation in lung tissue followi...

  1. ISKANJE IN REALIZACIJA NOVIH POSLOVNIH IDEJ ZA REŠEVANJE »GRADBENEGA PODJETJA« V TEŽAVAH

    OpenAIRE

    Cerovec, Marija

    2012-01-01

    Stalne spremembe na trgu vplivajo na podjetja, da neprenehoma ustvarjajo nove proizvode ali storitve. Podjetja, ki tem spremembam sledijo, v njih prepoznavajo nove priložnosti za svoj razvoj. Razvoj podjetja je povezan z dejstvom, da podjetje spodbuja inovatinovst v svojih poslovnih procesih in ustvarja dodano vrednost v svojih izdekih in storitvah. Prvi pogoj za ustvarjalnost v podjetju je ustvarjalni in inovativni vodstveni kader ali podjetnik, ki bo znal prepričati svoje zaposlene, da spr...

  2. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury

    OpenAIRE

    Feinman, Rena; Deitch, Edwin A.; Watkins, Anthony C.; Abungu, Billy; Colorado, Iriana; Kannan, Kolenkode B.; Sheth, Sharvil U.; Caputo, Francis J.; Lu, Qi; Ramanathan, Madhuri; Attan, Shirhan; Badami, Chirag D.; Doucet, Danielle; Barlos, Dimitrios; Bosch-Marce, Marta

    2010-01-01

    Acute lung injury (ALI) and the development of the multiple organ dysfunction syndrome (MODS) are major causes of death in trauma patients. Gut inflammation and loss of gut barrier function as a consequence of splanchnic ischemia-reperfusion (I/R) have been implicated as the initial triggering events that contribute to the development of the systemic inflammatory response, ALI, and MODS. Since hypoxia-inducible factor (HIF-1) is a key regulator of the physiological and pathophysiological resp...

  3. Proportional assistierte Spontanatmung mit automatischer Tubuskompensation versus druckunterstützte Spontanatmung bei experimentell induziertem akuten Lungenversagen

    OpenAIRE

    Bensberg, Ralf

    2010-01-01

    It has been suggested, that the preservation of some degree of spontaneous breathing might be advantageous in acute respiratory distress. Therefore, proportional assisted ventilation with automatic tube compensation (PAV/ATC) and pressure support ventilation (PSV) were compared in an animal model of acute lung injury (ALI) regarding gas exchange, haemodynamics and ventilation-perfusion distribution. Using repetitive bronchoalveolar lavage manoeuvre, ALI was induced in 20 pigs until PaO2/FiO2 ...

  4. ALICE - ARC integration

    OpenAIRE

    Anderlik, Csaba; Gregersen, Anders Rhod; Kleist, Josva; Peters, Andreas; Siaz, Pablo

    2007-01-01

    AliEn or Alice Environment is the Gridware developed and used within the ALICE collaboration for storing and processing data in a distributed manner. ARC (Advanced Resource Connector) is the Grid middleware deployed across the Nordic countries and gluing together the resources within the Nordic Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructur...

  5. OBVLADOVANJE KONFLIKTOV V ORGANIZACIJI

    OpenAIRE

    Benkič, Sabina

    2014-01-01

    V diplomski nalogi opredeljujemo pomen konfliktov in njihovo reševanje v organizaciji. V vsaki organizaciji kdaj naletimo na konfliktno situacijo. Konflikti nastanejo zaradi nasprotij interesov med posamezniki ali skupinami. Lahko bi rekli, da konflikti slabšajo in zavirajo poslovanje organizacij, kar se lahko kaže v nemotiviranosti zaposlenih, neproduktivnosti ali celo neuspešnosti organizacij. Sprejeti jih moramo kot nekaj vsakdanjega in naravnega, česar se ne moremo izogniti. Ključnega po...

  6. Spectroscopic Approach to Capillary-Alveolar Membrane Damage Induced Acute Lung Injury

    Directory of Open Access Journals (Sweden)

    Jing Wang

    1999-01-01

    Full Text Available BACKGROUND: Acute (or adult respiratory distress syndrome (ARDS is often associated with a high mortality rate in the critical care population. The term acute lung injury (ALI, a primitive phase of ARDS, was introduced by the European and American consensus groups to provide early diagnoses of ARDS. The pathophysiological characterization of ALI/ARDS – an increased pulmonary capillary-alveolar membrane barrier permeability – is generally not included in current intensive care unit diagnosis criteria.

  7. Cardiorespiratory effects of recruitment maneuvers and positive end expiratory pressure in an experimental context of acute lung injury and pulmonary hypertension

    OpenAIRE

    Doras, Camille; Le Guen, Morgan; Peták, Ferenc; Habre, Walid

    2015-01-01

    Background Recruitment maneuvers (RM) and positive end expiratory pressure (PEEP) are the cornerstone of the open lung strategy during ventilation, particularly during acute lung injury (ALI). However, these interventions may impact the pulmonary circulation and induce hemodynamic and respiratory effects, which in turn may be critical in case of pulmonary hypertension (PHT). We aimed to establish how ALI and PHT influence the cardiorespiratory effects of RM and PEEP. Methods Rabbits control o...

  8. OPTICAL IMAGING OF LIPOPOLYSACCHARIDE-INDUCED OXIDATIVE STRESS IN ACUTE LUNG INJURY FROM HYPEROXIA AND SEPSIS

    OpenAIRE

    Sepehr, Reyhaneh; Audi, Said H.; Maleki, Sepideh; Staniszewski, Kevin; EIS, ANNIE L.; Konduri, Girija G.; Ranji, Mahsa

    2013-01-01

    Reactive oxygen species (ROS) have been implicated in the pathogenesis of many acute and chronic pulmonary disorders such as acute lung injury (ALI) in adults and bronchopulmonary dysplasia (BPD) in premature infants. Bacterial infection and oxygen toxicity, which result in pulmonary vascular endothelial injury, contribute to impaired vascular growth and alveolar simplification seen in the lungs of premature infants with BPD. Hyperoxia induces ALI, reduces cell proliferation, causes DNA damag...

  9. Dramatisk og farverig

    DEFF Research Database (Denmark)

    Haarder, Jon Helt

    2007-01-01

    Khaled Hosseini: UNDER EN STRÅLENDE SOL (A Thousand Splendid Suns) Oversat fra amerikansk af Alis Friis Caspersen 320 sider, 299,95 kr. Cicero UDKOMMER I DAG. Fire stjerner Udgivelsesdato: 22.05......Khaled Hosseini: UNDER EN STRÅLENDE SOL (A Thousand Splendid Suns) Oversat fra amerikansk af Alis Friis Caspersen 320 sider, 299,95 kr. Cicero UDKOMMER I DAG. Fire stjerner Udgivelsesdato: 22.05...

  10. Effects of sigh during pressure control and pressure support ventilation in pulmonary and extrapulmonary mild acute lung injury

    OpenAIRE

    Moraes, Lillian; Santos, Cíntia Lourenco; Santos, Raquel Souza; Cruz, Fernanda Ferreira; Saddy, Felipe; Morales, Marcelo Marcos; Capelozzi, Vera Luiza; Silva, Pedro Leme; Gama de Abreu, Marcelo; Garcia, Cristiane Sousa Nascimento Baez; Pelosi, Paolo; Rocco, Patricia Rieken Macedo

    2014-01-01

    Introduction Sigh improves oxygenation and lung mechanics during pressure control ventilation (PCV) and pressure support ventilation (PSV) in patients with acute respiratory distress syndrome. However, so far, no study has evaluated the biological impact of sigh during PCV or PSV on the lung and distal organs in experimental pulmonary (p) and extrapulmonary (exp) mild acute lung injury (ALI). Methods In 48 Wistar rats, ALI was induced by Escherichia coli lipopolysaccharide either intratrachea...

  11. Cleavage of endogenous γENaC and elevated abundance of αENaC are associated with increased Na+ transport in response to apical fluid volume expansion in human H441 airway epithelial cells

    OpenAIRE

    Tan, Chong D.; Selvanathar, Indusha A.; Baines, Deborah L.

    2011-01-01

    Using human H441 airway epithelial cells cultured at air–liquid interface (ALI), we have uniquely correlated the functional response to apical fluid volume expansion with the abundance and cleavage of endogenous α- and γENaC proteins in the apical membrane. Monolayers cultured at ALI rapidly elevated I sc when inserted into fluid-filled Ussing chambers. The increase in I sc was not significantly augmented by the apical addition of trypsin, and elevation was abolished by the protease inhibitor...

  12. Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy

    OpenAIRE

    Maha Gamal; Zainab Abdel Wahab; Mohamed Eshra; Laila Rashed; Nivin Sharawy

    2014-01-01

    Objective. Encephalopathy and brain edema are serious complications of acute liver injury and may lead to rapid death of patients. The present study was designed to investigate the role of the inflammatory mediators and oxidative stress in the cytotoxic brain oedema and the neuroprotective effects of both minocycline and dexamethasone. Methods. 48 male albino rats were divided into 4 groups: control group, acute liver injury (ALI) group, minocycline pretreated ALI group, and dexamethasone...

  13. Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury

    OpenAIRE

    Deqing Wu; Yue Zeng; Yuting Fan; Jianghong Wu; Tunike Mulatibieke; Jianbo Ni; Ge Yu; Rong Wan; Xingpeng Wang; Guoyong Hu

    2016-01-01

    Junctional adhesion molecule-C (JAM-C) plays a key role in the promotion of the reverse transendothelial migration (rTEM) of neutrophils, which contributes to the dissemination of systemic inflammation and to secondary organ damage. During acute pancreatitis (AP), systemic inflammatory responses lead to distant organ damage and typically result in acute lung injury (ALI). Here, we investigated the role of rTEM neutrophils in AP-associated ALI and the molecular mechanisms by which JAM-C regula...

  14. Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPS-induced acute lung injury in rats

    OpenAIRE

    Li Jianjun; Li Dong; Liu Xiaomei; Tang Shuhai; Wei Fengcai

    2012-01-01

    Abstract Background Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties and simultaneously lack the ability to illicit immune responses. Hence, MSCs have emerged as a promising candidate for cellular therapeutics for inflammatory diseases. Within the context of this study, we investigated whether human umbilical cord-derived mesenchymal stem cells (UC-MSCs) could ameliorate lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in a rat model. Methods ALI was induced ...

  15. Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury

    OpenAIRE

    Silva, Pedro L; Cruz, Fernanda F.; Fujisaki, Livia C; Gisele P. Oliveira; Samary, Cynthia S; Ornellas, Debora S; Maron-Gutierrez, Tatiana; Rocha, Nazareth N.; Goldenberg, Regina; Garcia, Cristiane SNB; MARCELO M. MORALES; Vera L. Capelozzi; Gama de Abreu, Marcelo; Pelosi, Paolo; Rocco, Patricia RM

    2010-01-01

    Introduction Recruitment maneuvers (RMs) seem to be more effective in extrapulmonary acute lung injury (ALI), caused mainly by sepsis, than in pulmonary ALI. Nevertheless, the maintenance of adequate volemic status is particularly challenging in sepsis. Since the interaction between volemic status and RMs is not well established, we investigated the effects of RMs on lung and distal organs in the presence of hypovolemia, normovolemia, and hypervolemia in a model of extrapulmonary lung injury ...

  16. Effects of overinflation on procollagen type III expression in experimental acute lung injury

    OpenAIRE

    de Carvalho, Maria-Eudóxia Pilotto; Dolhnikoff, Marisa; Meireles, Sibele Inácio; Reis, Luiz Fernando Lima; Martins, Milton Arruda; Deheinzelin, Daniel

    2007-01-01

    Introduction In acute lung injury (ALI), elevation of procollagen type III (PC III) occurs early and has an adverse impact on outcome. We examined whether different high-inflation strategies of mechanical ventilation (MV) in oleic acid (OA) ALI alter regional expression of PC III. Methods We designed an experimental, randomized, and controlled protocol in which rats were allocated to two control groups (no injury, recruited [alveolar recruitment maneuver after tracheotomy without MV; n = 4 ra...

  17. PREDNOSTI IN SLABOSTI VEGETARIJANSKE PREHRANE

    OpenAIRE

    Grut, Petra

    2009-01-01

    Diplomska naloga predstavlja raziskavo med vegetarijanci ter vsejedi. Primerjamo njihov način prehranjevanja, vplive prehrane na zdravje in življenje. Anketiranih je bilo 50 naključno izbranih vegetarijancev ter 50 vsejedov v eni izmed mariborskih restavracij. Stari so bili med 20 ter 60 let. Cilji raziskave so bili: - Ugotoviti, ali imajo vegetarijanci manj zdravstvenih težav kot vsejedi. - Ugotoviti katera vrsta vegetarijancev prevladuje v našem okolju. - Ugotoviti, ali ljudje ...

  18. Prostacyclin-Inhalation in Kombination mit Almitrine zur Therapie des akuten Lungenversagens

    OpenAIRE

    Kurth, Roland

    2003-01-01

    The aim of this prospective controlled animal study was to investigate a possible additive effect of combined inhaled prostacycline and intravenous almitrine bismesylate (ALM) on pulmonary ventilation-perfusion ratio in acute lung injury (ALI) compared to inhaled prostacycline or intravenous ALM alone. Experimental ALI was established in all 24 pigs (weighing 30+/-3 kg) by repeated lung lavage. Animals were randomly assigned to receive either 25 ng/kg/min inhaled prostacycline alone, 1 µg/kg/...

  19. Therapeutic Modulation of Coagulation and Fibrinolysis in Acute Lung Injury and the Acute Respiratory Distress Syndrome

    OpenAIRE

    Sebag, Sara C.; Bastarache, Julie A.; Ware, Lorraine B.

    2011-01-01

    Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are characterized by excessive intra-alveolar fibrin deposition, driven, at least in part by inflammation. The imbalance between activation of coagulation and inhibition of fibrinolysis in patients with ALI/ARDS favors fibrin formation and appears to occur both systemically and in the lung and airspace. Tissue factor (TF), a key mediator of the activation of coagulation in the lung, has been implicated in the pathogenesis ...

  20. Radiological anatomy of the C7 vertebra: Clinical implications in spine surgery.

    OpenAIRE

    Fatih Keskin; Fatih Erdi; Alaaddin Nayman; Ozan Babaoglu; Kalkan Erdal; Ali Fahir Ozer

    2015-01-01

    Radiological anatomy of the C7 vertebra: Clinical implications in spine surgery Fatih Keskin, Fatih Erdi, Alaaddin Nayman, Ozan Babaoglu, Kalkan Erdal and Ali Ozer Journal of Craniovertebral Junction and Spine. 6.1 (January-March 2015): p30. Copyright: COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd. http://www.jcvjs.com/ Full Text: Byline: Fatih. Keskin, Fatih. Erdi, Alaaddin. Nayman, Ozan. Babaoglu, Kalkan. Erdal, Ali. Ozer Context: This study was designed to understand and define th...

  1. Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways

    OpenAIRE

    Shuang Peng; Nan Hang; Wen Liu; Wenjie Guo; Chunhong Jiang; Xiaoling Yang; Qiang Xu; Yang Sun

    2016-01-01

    Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a severe, life-threatening medical condition characterized by widespread inflammation in the lungs, and is a significant source of morbidity and mortality in the patient population. New therapies for the treatment of ALI are desperately needed. In the present study, we examined the effect of andrographolide sulfonate, a water-soluble form of andrographolide (trade name: Xi-Yan-Ping Injection), on lipopolysaccharide (LPS)...

  2. Role of Ventilation in Cases of Acute Respiratory Distress Syndrome /Acute Lung injury

    Directory of Open Access Journals (Sweden)

    Hemant M Shah

    2014-02-01

    Conclusion: Early application of Non-invasive ventilation in patients of ARDS/ALI, in form of high PEEP and low Tidal Volume, which helps in clearance of secretion and prevents collapse of alveoli and thereby decreases need of invasive ventilation as well as decreases the mortality due to ARDS/ALI;and thereby 100% chances of improvement. In invasive ventilation, outcome of the patients is not favorable. [Natl J Med Res 2014; 4(1.000: 48-52

  3. Role of Ventilation in Cases of Acute Respiratory Distress Syndrome /Acute Lung injury

    OpenAIRE

    Hemant M Shah; Shilpa B Sutariya; Parul M Bhatt; Nishil Shah; Shweta Gamit

    2014-01-01

    Introduction: Acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are characterized by refractory hypoxemia that develops secondary to high-permeability pulmonary edema. These syndromes are gaining more attention as a means of better comprehending the pathophysiology of ARDS and possiblyfor modifying ventilatory management. In this context a study was done to compare role of invasive and non-invasive ventilation in cases of ARDS/ALI. Methods: in this study patients of AR...

  4. Lithium abundance/surface activity connections in solar-type Pleiades

    OpenAIRE

    Clarke, D.; MacDonald, E. C.; Owens, S.

    2004-01-01

    The relation between the lithium abundance, ALi, and photospheric activity of solar-type Pleiads is investigated for the first time via acquisition and analysis of B and V-band data. Predictions of activity levels of target stars were made according to the ALi/(B - V) relation and then compared with new CCD photometric measurements. Six sources behaved according to the predictions while one star (HII 676), with low predicted activity, exhibited the largest variability of the study; another st...

  5. Pattern Recognition Receptor–Dependent Mechanisms of Acute Lung Injury

    OpenAIRE

    Xiang, Meng; Fan, Jie

    2009-01-01

    Acute lung injury (ALI) that clinically manifests as acute respiratory distress syndrome is caused by an uncontrolled systemic inflammatory response resulting from clinical events including sepsis, major surgery and trauma. Innate immunity activation plays a central role in the development of ALI. Innate immunity is activated through families of related pattern recognition receptors (PRRs), which recognize conserved microbial motifs or pathogen-associated molecular patterns (PAMPs). Toll-like...

  6. α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo

    OpenAIRE

    Ibrahim MY; Hashim NM; Mohan S; Abdulla MA; Kamalidehghan B; Ghaderian M; Dehghan F; Ali LZ; Arbab IA; Yahayu M; Lian GE; Ahmadipour F; Ali HM

    2014-01-01

    Mohamed Yousif Ibrahim,1 Najihah Mohd Hashim,1 Syam Mohan,2 Mahmood Ameen Abdulla,3 Behnam Kamalidehghan,1 Mostafa Ghaderian,1,4 Firouzeh Dehghan,1,5 Landa Zeenelabdin Ali,1 Ismail Adam Arbab,6 Maizatulakmal Yahayu,7 Gwendoline Ee Cheng Lian,8 Fatemeh Ahmadipour,1 Hapipah Mohd Ali9 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Medical Research Centre, Jazan University, Jazan, Saudi Arabia; 3Department of Molecular Medicine, Faculty of Medicine Un...

  7. α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo

    OpenAIRE

    Ibrahim, Mohamed Yousif

    2014-01-01

    Mohamed Yousif Ibrahim,1 Najihah Mohd Hashim,1 Syam Mohan,2 Mahmood Ameen Abdulla,3 Behnam Kamalidehghan,1 Mostafa Ghaderian,1,4 Firouzeh Dehghan,1,5 Landa Zeenelabdin Ali,1 Ismail Adam Arbab,6 Maizatulakmal Yahayu,7 Gwendoline Ee Cheng Lian,8 Fatemeh Ahmadipour,1 Hapipah Mohd Ali9 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Medical Research Centre, Jazan University, Jazan, Saudi Arabia; 3Department of Molecular Medicine, Faculty of Medicine Un...

  8. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.

    Directory of Open Access Journals (Sweden)

    Jason D Christie

    Full Text Available Acute Lung Injury (ALI is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA approach to identify putative risk variants for ALI. Genome wide genotyping was performed using the Illumina Human Quad 610 BeadChip. We performed a two-stage GWA study followed by a third stage of functional characterization. In the discovery phase (Phase 1, we compared 600 European American trauma-associated ALI cases with 2266 European American population-based controls. We carried forward the top 1% of single nucleotide polymorphisms (SNPs at p<0.01 to a replication phase (Phase 2 comprised of a nested case-control design sample of 212 trauma-associated ALI cases and 283 at-risk trauma non-ALI controls from ongoing cohort studies. SNPs that replicated at the 0.05 level in Phase 2 were subject to functional validation (Phase 3 using expression quantitative trait loci (eQTL analyses in stimulated B-lymphoblastoid cell lines (B-LCL in family trios. 159 SNPs from the discovery phase replicated in Phase 2, including loci with prior evidence for a role in ALI pathogenesis. Functional evaluation of these replicated SNPs revealed rs471931 on 11q13.3 to exert a cis-regulatory effect on mRNA expression in the PPFIA1 gene (p = 0.0021. PPFIA1 encodes liprin alpha, a protein involved in cell adhesion, integrin expression, and cell-matrix interactions. This study supports the feasibility of future multi-center GWA investigations of ALI risk, and identifies PPFIA1 as a potential functional candidate ALI risk gene for future research.

  9. Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling

    OpenAIRE

    Lee Hsuan-Shu; Yu Chia-Jung; Chen Wang-Chuan; Lin Bor-Ru; Chang Huei-Min; Lee Yen-Chih; Chien Chiang-Ting; Chen Chau-Fong

    2009-01-01

    Abstract Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial apoptosis- and proinflammatory cytokine-signaling pathways, and possible mechanism(s) by which green tea (GT) extract modulates the apoptotic and proinflammatory signaling in rat. D-GalN induced hepatic hypoxia/hypoperfusion and triggered reactive oxygen species (ROS) production f...

  10. Sistem enkratne prijave Shibboleth

    OpenAIRE

    Železnik, Klemen

    2015-01-01

    Cilj protokola Shibboleth je predvsem razbremenitev večkratne avtentikacije uporabnikov znotraj na primer večjih javnih ali zasebnih ustanov, kot so univerze, podjetja, ki imajo razne aplikacije ali storitve, ki potrebujejo avtentikacijo. Protokol Shibboleth deluje na principu enkratne prijave, kar pomeni, da bi uporabnik potreboval le eno uporabniško ime in geslo za prijavo v vse aplikacije znotraj neke ustanove. V delu bomo najprej opisali koncepte protokola Shibboleth in njegove povezave z...

  11. The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1.

    Science.gov (United States)

    Liang, Xingsi; Zhang, Bin; Chen, Quan; Zhang, Jing; Lei, Biao; Li, Bo; Wei, Yangchao; Zhai, Run; Liang, Zhiqing; He, Songqing; Tang, Bo

    2016-01-01

    Characterized by its acute onset, critical condition, poor prognosis, and high mortality rate, severe acute pancreatitis (SAP) can cause multiple organ failure at its early stage, particularly acute lung injury (ALI). The pathogenesis of ALI is diffuse alveolar damage, including an increase in pulmonary microvascular permeability, a decrease in compliance, and invasion of many inflammatory cells. Corticosteroids are the main treatment method for ALI; however, the associated high toxicity and side effects induce pain in patients. Recent studies show that the effective components in many traditional Chinese medicines can effectively inhibit inflammation with few side effects, which can decrease the complications caused by steroid consumption. Based on these observations, the main objective of the current study is to investigate the effect of alpinetin, which is a flavonoid extracted from Alpinia katsumadai Hayata, on treating lung injury induced by SAP and to explore the mechanism underlying the alpinetin-mediated decrease in the extent of ALI. In this study, we have shown through in vitro experiments that a therapeutic dose of alpinetin can promote human pulmonary microvascular endothelial cell proliferation. We have also shown via in vitro and in vivo experiments that alpinetin upregulates aquaporin-1 and, thereby, inhibits tumor necrosis factor-α expression as well as reduces the degree of lung injury. Overall, our study shows that alpinetin alleviates SAP-induced ALI. The likely molecular mechanism includes upregulated aquaporin expression, which inhibits tumor necrosis factor-α and, thus, alleviates SAP-induced ALI. PMID:26966354

  12. ALICE-ARC integration

    International Nuclear Information System (INIS)

    AliEn or Alice Environment is the Grid middleware developed and used within the ALICE collaboration for storing and processing data in a distributed manner. ARC (Advanced Resource Connector) is the Grid middleware deployed across the Nordic countries and gluing together the resources within the Nordic Data Grid Facility (NDGF). In this paper we will present our approach to integrate AliEn and ARC, in the sense that ALICE data management and job processing can be carried out on the NDGF infrastructure, using the client tools available in AliEn. The inter-operation has two aspects, one is the data management part and the second the job management aspect. The first aspect was solved by using dCache across NDGF to handle data. Therefore, we will concentrate on the second part. Solving it, was somewhat cumbersome, mainly due to the different computing models employed by AliEn and ARC. AliEN uses an Agent based pull model while ARC handles jobs through the more 'traditional' push model. The solution comes as a module implementing the functionalities necessary to achieve AliEn job submission and management to ARC enabled sites

  13. Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

    Directory of Open Access Journals (Sweden)

    Daniely Cornélio Favarin

    2013-01-01

    Full Text Available Acute lung injury (ALI is a life-threatening syndrome that causes high morbidity and mortality worldwide. ALI is characterized by increased permeability of the alveolar-capillary membrane, edema, uncontrolled neutrophils migration to the lung, and diffuse alveolar damage, leading to acute hypoxemic respiratory failure. Although corticosteroids remain the mainstay of ALI treatment, they cause significant side effects. Agents of natural origin, such as medicinal plants and their secondary metabolites, mainly those with very few side effects, could be excellent alternatives for ALI treatment. Several studies, including our own, have demonstrated that plant extracts and/or secondary metabolites isolated from them reduce most ALI phenotypes in experimental animal models, including neutrophil recruitment to the lung, the production of pro-inflammatory cytokines and chemokines, edema, and vascular permeability. In this review, we summarized these studies and described the anti-inflammatory activity of various plant extracts, such as Ginkgo biloba and Punica granatum, and such secondary metabolites as epigallocatechin-3-gallate and ellagic acid. In addition, we highlight the medical potential of these extracts and plant-derived compounds for treating of ALI.

  14. Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy

    Directory of Open Access Journals (Sweden)

    Maha Gamal

    2014-01-01

    Full Text Available Objective. Encephalopathy and brain edema are serious complications of acute liver injury and may lead to rapid death of patients. The present study was designed to investigate the role of the inflammatory mediators and oxidative stress in the cytotoxic brain oedema and the neuroprotective effects of both minocycline and dexamethasone. Methods. 48 male albino rats were divided into 4 groups: control group, acute liver injury (ALI group, minocycline pretreated ALI group, and dexamethasone pretreated ALI group. 24 hours after acute liver injury serum ammonia, liver enzymes, brain levels of heme oxygenase-1 gene, iNOS gene expression, nitrite/nitrate, and cytokines were measured. In addition, the grades of encephalopathy and brain water content were assessed. Results. ALI was associated with significant increases in all measured inflammatory mediators, oxidative stress, iNOS gene expression, and nitrite/nitrate. Both minocycline and dexamethasone significantly modulated the inflammatory changes and the oxidative/nitrosative stress associated with ALI. However, only minocycline but not dexamethasone significantly reduced the cytotoxic brain oedema. Conclusion. Both minocycline and dexamethasone could modulate inflammatory and oxidative changes observed in brain after ALI and could be novel preventative therapy for hepatic encephalopathy episodes.

  15. Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome.

    Science.gov (United States)

    Sebag, Sara C; Bastarache, Julie A; Ware, Lorraine B

    2011-09-01

    Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are characterized by excessive intraalveolar fibrin deposition, driven, at least in part by inflammation. The imbalance between activation of coagulation and inhibition of fibrinolysis in patients with ALI/ARDS favors fibrin formation and appears to occur both systemically and in the lung and airspace. Tissue factor (TF), a key mediator of the activation of coagulation in the lung, has been implicated in the pathogenesis of ALI/ARDS. As such, there have been numerous investigations modulating TF activity in a variety of experimental systems in order to develop new therapeutic strategies for ALI/ARDS. This review will summarize current understanding of the role of TF and other proteins of the coagulation cascade as well the fibrinolysis pathway in the development of ALI/ARDS with an emphasis on the pathways that are potential therapeutic targets. These include the TF inhibitor pathway, the protein C pathway, antithrombin, heparin, and modulation of fibrinolysis through plasminogen activator- 1 (PAI-1) or plasminogen activators (PA). Although experimental studies show promising results, clinical trials to date have proven unsuccessful in improving patient outcomes. Modulation of coagulation and fibrinolysis has complex effects on both hemostasis and inflammatory pathways and further studies are needed to develop new treatment strategies for patients with ALI/ARDS. PMID:21401517

  16. Activation of PPARα by Wy-14643 ameliorates systemic lipopolysaccharide-induced acute lung injury

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Seong Ho, E-mail: yoosh@snu.ac.kr [Seoul National University Hospital, Biomedical Research Institute and Institute of Forensic Medicine, Seoul National University College of Medicine, Seoul (Korea, Republic of); Abdelmegeed, Mohamed A. [Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD (United States); Song, Byoung-Joon, E-mail: bj.song@nih.gov [Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD (United States)

    2013-07-05

    Highlights: •Activation of PPARα attenuated LPS-mediated acute lung injury. •Pretreatment with Wy-14643 decreased the levels of IFN-γ and IL-6 in ALI. •Nitrosative stress and lipid peroxidation were downregulated by PPARα activation. •PPARα agonists may be potential therapeutic targets for acute lung injury. -- Abstract: Acute lung injury (ALI) is a major cause of mortality and morbidity worldwide. The activation of peroxisome proliferator-activated receptor-α (PPARα) by its ligands, which include Wy-14643, has been implicated as a potential anti-inflammatory therapy. To address the beneficial efficacy of Wy-14643 for ALI along with systemic inflammation, the in vivo role of PPARα activation was investigated in a mouse model of lipopolysaccharide (LPS)-induced ALI. Using age-matched Ppara-null and wild-type mice, we demonstrate that the activation of PPARα by Wy-14643 attenuated LPS-mediated ALI. This was evidenced histologically by the significant alleviation of inflammatory manifestations and apoptosis observed in the lung tissues of wild-type mice, but not in the corresponding Ppara-null mice. This protective effect probably resulted from the inhibition of LPS-induced increases in pro-inflammatory cytokines and nitroxidative stress levels. These results suggest that the pharmacological activation of PPARα might have a therapeutic effect on LPS-induced ALI.

  17. Disaturated-phosphatidylcholine and Surfactant protein-B turnover in human acute lung injury and in control patients

    Directory of Open Access Journals (Sweden)

    Rizzi Sabina

    2011-03-01

    Full Text Available Abstract Background Patients with Adult Respiratory Distress Syndrome (ARDS and Acute Lung Injury (ALI have low concentrations of disaturated-phosphatidylcholine and surfactant protein-B in bronchoalveolar lavage fluid. No information is available on their turnover. Objectives To analyze disaturated-phosphatidylcholine and surfactant protein-B turnover in patients with ARDS/ALI and in human adults with normal lungs (controls. Methods 2H2O as precursor of disaturated-phosphatidylcholine-palmitate and 113C-Leucine as precursor of surfactant protein-B were administered intravenously to 12 patients with ARDS/ALI and to 8 controls. Disaturated-phosphatidylcholine and surfactant protein-B were isolated from serial tracheal aspirates, and their fractional synthetic rate was derived from the 2H and 13C enrichment curves, obtained by gas chromatography mass spectrometry. Disaturated-phosphatidylcholine, surfactant protein-B, and protein concentrations in tracheal aspirates were also measured. Results 1 Surfactant protein-B turned over at faster rate than disaturated-phosphatidylcholine both in ARDS/ALI patients and in controls. 2 In patients with ARDS/ALI the fractional synthesis rate of disaturated-phosphatidylcholine was 3.1 times higher than in controls (p Conclusions 1 Disaturated-phosphatidylcholine and surfactant protein-B have a different turnover both in healthy and diseased lungs. 2 In ARDS/ALI the synthesis of these two surfactant components may be differently regulated.

  18. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.

    Science.gov (United States)

    Imai, Yumiko; Kuba, Keiji; Neely, G Greg; Yaghubian-Malhami, Rubina; Perkmann, Thomas; van Loo, Geert; Ermolaeva, Maria; Veldhuizen, Ruud; Leung, Y H Connie; Wang, Hongliang; Liu, Haolin; Sun, Yang; Pasparakis, Manolis; Kopf, Manfred; Mech, Christin; Bavari, Sina; Peiris, J S Malik; Slutsky, Arthur S; Akira, Shizuo; Hultqvist, Malin; Holmdahl, Rikard; Nicholls, John; Jiang, Chengyu; Binder, Christoph J; Penninger, Josef M

    2008-04-18

    Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI). We show that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI. The oxidized phospholipid (OxPL) OxPAPC was identified to induce lung injury and cytokine production by lung macrophages via TLR4-TRIF. We observed OxPL production in the lungs of humans and animals infected with SARS, Anthrax, or H5N1. Pulmonary challenge with an inactivated H5N1 avian influenza virus rapidly induces ALI and OxPL formation in mice. Loss of TLR4 or TRIF expression protects mice from H5N1-induced ALI. Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI.

  19. The clinical usefulness of extravascular lung water and pulmonary vascular permeability index to diagnose and characterize pulmonary edema: a prospective multicenter study on the quantitative differential diagnostic definition for acute lung injury/acute respiratory distress syndrome

    Science.gov (United States)

    2012-01-01

    Introduction Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is characterized by features other than increased pulmonary vascular permeability. Pulmonary vascular permeability combined with increased extravascular lung water content has been considered a quantitative diagnostic criterion of ALI/ARDS. This prospective, multi-institutional, observational study aimed to clarify the clinical pathophysiological features of ALI/ARDS and establish its quantitative diagnostic criteria. Methods The extravascular lung water index (EVLWI) and the pulmonary vascular permeability index (PVPI) were measured using the transpulmonary thermodilution method in 266 patients with PaO2/FiO2 ratio ≤ 300 mmHg and bilateral infiltration on chest radiography, in 23 ICUs of academic tertiary referral hospitals. Pulmonary edema was defined as EVLWI ≥ 10 ml/kg. Three experts retrospectively determined the pathophysiological features of respiratory insufficiency by considering the patients' history, clinical presentation, chest computed tomography and radiography, echocardiography, EVLWI and brain natriuretic peptide level, and the time course of all preceding findings under systemic and respiratory therapy. Results Patients were divided into the following three categories on the basis of the pathophysiological diagnostic differentiation of respiratory insufficiency: ALI/ARDS, cardiogenic edema, and pleural effusion with atelectasis, which were noted in 207 patients, 26 patients, and 33 patients, respectively. EVLWI was greater in ALI/ARDS and cardiogenic edema patients than in patients with pleural effusion with atelectasis (18.5 ± 6.8, 14.4 ± 4.0, and 8.3 ± 2.1, respectively; P < 0.01). PVPI was higher in ALI/ARDS patients than in cardiogenic edema or pleural effusion with atelectasis patients (3.2 ± 1.4, 2.0 ± 0.8, and 1.6 ± 0.5; P < 0.01). In ALI/ARDS patients, EVLWI increased with increasing pulmonary vascular permeability (r = 0.729, P < 0.01) and was weakly

  20. Allergic Lung Inflammation Reduces Tissue Invasion and Enhances Survival from Pulmonary Pneumococcal Infection in Mice, Which Correlates with Increased Expression of Transforming Growth Factor β1 and SiglecF(low) Alveolar Macrophages.

    Science.gov (United States)

    Sanfilippo, Alan M; Furuya, Yoichi; Roberts, Sean; Salmon, Sharon L; Metzger, Dennis W

    2015-07-01

    Asthma is generally thought to confer an increased risk for invasive pneumococcal disease (IPD) in humans. However, recent reports suggest that mortality rates from IPD are unaffected in patients with asthma and that chronic obstructive pulmonary disease (COPD), a condition similar to asthma, protects against the development of complicated pneumonia. To clarify the effects of asthma on the subsequent susceptibility to pneumococcal infection, ovalbumin (OVA)-induced allergic lung inflammation (ALI) was induced in mice followed by intranasal infection with A66.1 serotype 3 Streptococcus pneumoniae. Surprisingly, mice with ALI were significantly more resistant to lethal infection than non-ALI mice. The heightened resistance observed following ALI correlated with enhanced early clearance of pneumococci from the lung, decreased bacterial invasion from the airway into the lung tissue, a blunted inflammatory cytokine and neutrophil response to infection, and enhanced expression of transforming growth factor β1 (TGF-β1). Neutrophil depletion prior to infection had no effect on enhanced early bacterial clearance or resistance to IPD in mice with ALI. Although eosinophils recruited into the lung during ALI appeared to be capable of phagocytizing bacteria, neutralization of interleukin-5 (IL-5) to inhibit eosinophil recruitment likewise had no effect on early clearance or survival following infection. However, enhanced resistance was associated with an increase in levels of clodronate-sensitive, phagocytic SiglecF(low) alveolar macrophages within the airways following ALI. These findings suggest that, while the risk of developing IPD may actually be decreased in patients with acute asthma, additional clinical data are needed to better understand the risk of IPD in patients with different asthma phenotypes. PMID:25964474