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Sample records for alfred lothar wegener

  1. Alfred Wegener - en ilisimatoorsuaq

    DEFF Research Database (Denmark)

    Andersen, Jan

    2007-01-01

    Den naturvidenskabelige grønlandsforskning i begyndelsen af 1900-tallet skulle ikke involvere sig med Grønland. Dens projekt handlede om naturen - ikke kulturen. Wegener er kendt for sin kontinentaldriftsteori, der ofte fremstilles som et resultat af Danmark-ekspeditionens videnskabelige arbejde....... Da Wegener som medlem af ekspeditionen opholdt sig i Nordøstgrønland var tanken om kontinentaldrift imidlertid endnu ikke faldet ham ind. Vi har hans egne ord for, at ideen først opstod i 1910....

  2. Alfred Wegener-From Continental Drift to Plate Tectonics

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 10; Issue 6. Alfred Wegener – From Continental Drift to Plate Tectonics. A J Saigeetha Ravinder Kumar Banyal. General Article Volume 10 Issue 6 June 2005 pp 43-59. Fulltext. Click here to view fulltext PDF. Permanent link:

  3. Research Vessel HEINCKE Operated by the Alfred-Wegener-Institute

    Directory of Open Access Journals (Sweden)

    Rainer Knust

    2017-11-01

    Full Text Available HEINCKE operated by the Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung, is a medium size multipurpose research vessel, which was designed for long-term cruises throughout the North Atlantic Sea up to Svalbard and the adjacent shelf seas. She offers work places and accommodation for 12 scientists and 12 crew members. The operating range of this low noise ship is about 7500 nautical miles (= 30 passage days. Four laboratories (wet, dry, constant temperature controlled and hydroacoustic/CTD offer almost vibration-free work places. Additionally space is available for special containers. The ship is equipped with several winch systems, cranes, and sonar systems, which allow a wide range of biological, chemical, oceanographic, geological and geophysical research applications. The onboard science support equipment allows working in water depths of up to approximately 2000 meters.

  4. Archive of Geosample Information from the Alfred-Wegener-Institut (AWI) Core Repository

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Alfred-Wegener-Institut (AWI) made a one-time contribution to the Index to Marine and Lacustrine Geological Samples (IMLGS) database of metadata describing 1820...

  5. Alfred Wegener - From Continental Drift to Plate Tectonics

    Indian Academy of Sciences (India)

    permanently fixed on the Earth's surface and their positions do not change with time. In order to explain a wide range of confusing geological data, they supported the existence of huge land bridges that seem to have connected the .... courageously uses his intelligence." Needless to say, Wegener's new theory sparked a ...

  6. Neumayer III and Kohnen Station in Antarctica operated by the Alfred Wegener Institute

    Directory of Open Access Journals (Sweden)

    Christine Wesche

    2016-08-01

    Full Text Available The Alfred Wegener Institute operates two stations in Dronning Maud Land, Antarctica. The German overwintering station Neumayer III is located on the Ekström Ice Shelf at 70°40’S and 08°16’W and is the logistics base for three long-term observatories (meteorology, air chemistry and geophysics and nearby research activities. Due to the vicinity to the coast (ca. 20 km from the ice shelf edge, the Neumayer III Station is the junction for many German Antarctic expeditions, especially as the starting point for the supply traverse for the second German station Kohnen. The summer station Kohnen is located about 600 km from the coast and 750 km from Neumayer III Station on the Antarctic plateau at 75°S and 00°04’E. It was erected as the base for the deep-drilling ice core project, which took place between 2001 and 2006. Since then Kohnen Station is used as a logistics base for different research projects.

  7. [Wegener and Wegener's disease].

    Science.gov (United States)

    Knuistingh Neven, Arie

    2012-01-01

    This article describes the history and significance of the eponym 'Wegener'. After the American College of Chest Physicians awarded Wegener with the Master Clinician Award, discussion about his Nazi past arose. Should the eponym 'Wegener' be maintained?

  8. Alfred Werner

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Alfred Werner. Articles written in Resonance – Journal of Science Education. Volume 4 Issue 9 September 1999 pp 90-94 Reflections. On the Constitution and Configuration of Higher-order Compounds · Alfred Werner · More Details Fulltext PDF ...

  9. Alfred Nobel

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Alfred Nobel. Articles written in Resonance – Journal of Science Education. Volume 18 Issue 6 June 2013 pp 581-585 Classics. Letters Patent No.78,317 · Alfred Nobel · More Details Fulltext PDF ...

  10. Alfred Hansen

    DEFF Research Database (Denmark)

    Friis, Ib; Wind, Peter; Pedersen, Henrik Ærenlund

    2008-01-01

    Nekrolog over botanikeren Alfred Hansen, leder af Dansk Herbarium på Botanisk Museum, Københavns Universitet, med gennemgang af hans videnskabelige og formidlende publikationer og indsats som samler af videnskabeligt materiale.......Nekrolog over botanikeren Alfred Hansen, leder af Dansk Herbarium på Botanisk Museum, Københavns Universitet, med gennemgang af hans videnskabelige og formidlende publikationer og indsats som samler af videnskabeligt materiale....

  11. Alfred Werner

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 4; Issue 9. Alfred Werner. Animesh Chakravorty. Article-in-a-Box Volume 4 Issue 9 September 1999 pp 2-3. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/004/09/0002-0003. Author Affiliations. Animesh ...

  12. Alfred Schaffer

    African Journals Online (AJOL)

    Owner

    Kom in, dit vries daar buite bevat 'n keuse uit die poësie van Alfred Schaffer, uitgesoek deur die digter self en uit Nederlands vertaal deur. Daniel Hugo. Schaffer woon sedert 1996 byna onafgebroke in Suid-Afrika. .... dinsky, Pollock, Newman, Rothko and Still, die abstrakte sublieme noem. Schaffer is myns insiens as ...

  13. Granulomatose de Wegener Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    Telma Antunes

    2005-07-01

    Full Text Available A granulomatose de Wegener caracteriza-se por vasculite necrosante granulomatosa que acomete preferencialmente vias aéreas superiores, inferiores e rins. Seu diagnóstico é feito associando-se as manifestações clínicas, radiológicas (multiplos nódulos escavados e os achados anatomopatológicos e o anticorpo anticitoplasma de neutrófilos positivo. O tratamento com corticosteróides e ciclofosfamida leva a 90% de remissão da doença em 1 ano.Wegener's granulomatosis is characterized by granulomatous necrotizing vasculitis that primarily affects the airways (upper and lower and the kidneys. The diagnosis is made by analyzing the clinical and radiological manifestations (multiple pulmonary cavitations, together with the pathological findings and results of the test for cytoplasmic-pattern antineutrophil cytoplasmic antibodies. Treatment consists of corticosteroids and cyclophosphamide and leads to remission of the disease within one year in 90% of cases.

  14. Pachymeningitis in Wegener`s granulomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Burrell, H.; McConachie, N.S. [City and Univeristy Hospital, Nottingham (United Kingdom). Department of Radiology

    1998-11-01

    A case of Wegener`s granulomatosis is described in which meningeal thickening and enhancement was demonstrated on MR imaging. The diagnosis was suggested by the clinical picture, imaging findings and a positive anti-neutrophil cytoplasmic antibody; and confirmed by biopsy of ethmoidal tissue. Copyright (1998) Blackwell Science Pty Ltd 17 refs., 1 fig.

  15. Alfred Bernhard Nobel

    Indian Academy of Sciences (India)

    IAS Admin

    continues to teach and do research. His work is in the area of organosilicon chemistry ... entrepreneurial skill as Alfred Nobel. Early Life in Sweden and Russia. Alfred Nobel was born on 21st of ... was also able to hire private teachers to give his children good education which included science, literature, and languages.

  16. Alfred Wallaces evolutionsteori

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen; Winterdahl, Michael; Wang, Tobias

    2013-01-01

    I år er det hundrede år siden Alfred Wallace døde. Uafhængigt af Charles Darwin kom han på sporet af en evolutionsteori baseret på naturlig udvælgelse. Officielt blev begge teorier offentliggjort samtidigt på et møde i London i 1858, men i dag er Alfred Wallace glemt af de fleste....

  17. Alfred Wegener - From Continental Drift to Plate Tectonics

    Indian Academy of Sciences (India)

    The seawater occupies more than 70% of the Earth's surface. Several oceanographic studies and deep-sea surv~ys carried out after the World War II, established the fact that the ocean basement is not as flat and featureless as it was originally thought. The sea floor consists of Mid-Ocean ridges, huge volcanic moun-.

  18. WEGENER GRANULOMATOSIS- CASE REPORT

    Directory of Open Access Journals (Sweden)

    Ivanka Djordjevic

    2008-10-01

    Full Text Available Wegener granulomatosis is uncommon multisystemic disease, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tracts and general focal necrotizing vasculitis (Commonly known as „Wegener's triad“. The lungs are involved in 72 per cent of patients and the clinic and radiographic findings indicated bilateral pulmonary nodules of varying size and definition, cavitated in half of the patients, accompanied by the nodular lesion with a rare involvement of the pleura.We described a case of 62-year-old women with pansinusitis, mild azotemia and initial respiratory tract symptoms such as chronic cough and occasional hemoptysis. Due to bilateral nodular infiltrates in lungs on chest radiogram she was initially treated for smear negative pulmonary tuberculosis, but without expected antituberculous response. An additional diagnostic procedure pointed to Morbus Wegener.Two patterns of ANCA positive immunofluorescence are recognized as reliable and valuable diagnostic tools in the absence of histopathology for the diagnosis of Wegener granulomatosis.

  19. The Canonical Alfred Hitchcock

    Science.gov (United States)

    Lewis, Michael J.

    2010-01-01

    Alfred Hitchcock is a major figure of popular culture. He was one of the founding fathers of the cinematic art and, together with Eisenstein and Murnau, helped define its visual language. So fruitful was he that a single film could spawn an entire genre, as "Psycho" helped create the modern horror film and "North by Northwest" the style and tone…

  20. The Other Alfred Binet.

    Science.gov (United States)

    Siegler, Robert S.

    1992-01-01

    Reviews the major contributions of Alfred Binet. Explains why the fame of the Binet-Simon Intelligence Scale was so long lasting whereas that of his other contributions was so fleeting. Discusses implications of his contributions for current efforts to formulate unified theories of cognition and cognitive development. (Author/GLR)

  1. Haddon, Prof. Alfred Cort

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1936 Honorary. Haddon, Prof. Alfred Cort. Date of birth: 24 May 1855. Date of death: 20 April 1940. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held from ...

  2. Kastler, Prof. Alfred

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1970 Honorary. Kastler, Prof. Alfred Nobel Laureate (Physics) - 1966. Date of birth: 3 May 1902. Date of death: 7 January 1984. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science ...

  3. Haddon, Prof. Alfred Cort

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1936 Honorary. Haddon, Prof. Alfred Cort. Date of birth: 24 May 1855. Date of death: 20 April 1940. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the ...

  4. Alfred Bernhard Nobel

    Indian Academy of Sciences (India)

    IAS Admin

    Alfred Nobel was born in Sweden, but lived in many countries in Europe at different points of time. He went through many ups and downs during his life. He invented dynamite, a controllable explosive, which greatly enhanced the pace of industrialization by accelerating the process of construction of roads, railways, canals, ...

  5. Wang Yongbo & Lothar Ledderose (eds.: Buddhist Stone Sutras in China: Shandong Province, Vol. 1.

    Directory of Open Access Journals (Sweden)

    Henrik H. Sørensen

    2015-01-01

    Full Text Available This contribution offers a review of Wang Yongbo's and Lothar Ledderose's Buddhist Stone Sutras in China: Shandong Province, Vol. 1. Hangzhou and Wiesbaden: Harrassowitz and China Academy of Art Press, 2014. XXIV + 506 pages, hardcover € [D] 158, ISBN 978–3–447–06931–1.

  6. Recepción temprana de la teoría de la deriva continental y su competencia con las teorías rivales

    Directory of Open Access Journals (Sweden)

    Pérez-Malváez, Carlos

    2003-06-01

    Full Text Available In 1912 Alfred Lothar Wegener proposed the theory of the continental drift. Wegener thought that the displacement explained more paleontological and geophysical data than any other rival program. The great virtue of the drift theory resided in their great capacity of synthesis. Wegener appealed to the information provided by the Geology, Paleontology and Paleoclimatology.

    Alfred Lothar Wegener propuso la teoría de la deriva continental en 1912. Wegener ciertamente pensó que el desplazamiento explicaba mas datos paleontológicos y geofísicos que cualquiera de los programas de investigación establecidos. Desde luego, la gran virtud de la teoría de la deriva fue su gran capacidad de síntesis. Wegener recurrió a la información que provenía de la Geología, Geofísica, Paleontología y Paleoclimatología.

  7. Wegener granulomatosis masquerading as pneumonia.

    Science.gov (United States)

    Theodorou, D J; Theodorou, S J; Mpougias, K; Mastora, M; Stefanaki, S; Akritidis, N C

    2010-01-01

    We report a case of an elderly patient with a limited form of Wegener granulomatosis, which simulated the clinical and imaging features of organizing pneumonia. Here we call attention to this atypical case presentation that eloquently illustrates the many faces of Wegener granulomatosis.

  8. Schnittke, Alfred: Requiem / Didier Louis

    Index Scriptorium Estoniae

    Louis, Didier

    1996-01-01

    Uuest heliplaadist "Schnittke, Alfred: Requiem; Gorecki: Miserere. Solistes vocaux et instrumentaux, Choeur de chambre Eric Ericson, Choeur de la Radio Suedoise, Tõnu Kaljuste" Caprice CAP 21 515, distribution Disques Concord (CD: 160F). TT: 1h 08'49"

  9. Wegener and his Theory of Continental Drift

    Indian Academy of Sciences (India)

    they held that Wegener, not being a geologist by training, was unaware of the nuances of geological fieldwork and was meddling in topics outside his areas of competence. Wegener's Response. Convinced of its strength and tolerant about the limitations of his theory, Wegener sought to silence his critics by securing.

  10. Granulomatose de Wegener: relatos de casos Wegener's granulomatosis: cases reports

    Directory of Open Access Journals (Sweden)

    Ivana Cardoso Pereira

    2007-12-01

    Full Text Available A granulomatose de Wegener é descrita como uma tríade de lesões: granuloma necrosante do trato respiratório, vasculite disseminada e glomerulonefrite. Pode ocorrer de maneira sistêmica ou localizada. O envolvimento ocular e orbitário é comum em ambas as formas da doença, estando presente em 50% dos casos. O exame anatomopatológico e o c-ANCA+ foram fundamentais no diagnóstico efetivo da granulomatose de Wegener a despeito do envolvimento sistêmico nos casos apresentados.Wegener granulomatosis (WG is characterized by a classic triad of granulomatous inflammation of the respiratory tract, necrotizing vasculitis and nephritis. The absence of renal disease defines a subset of " limited WG" . Approximately 50% of WG patients develop ophthalmic disease. The histopatological study and +c-ANCA were essential to make a definite diagnosis in these cases.

  11. Da deriva continental de Wegener (1912) à moderna geodinâmica global

    OpenAIRE

    Dias, Rui

    2012-01-01

    Alfred Wegener formalizou o conceito de deriva continental (1912-1915) com base na mobilidade da superfície sólida da Terra; ele teve precursores mas, como meteorologista, conhecendo os movimentos rápidos dos fluidos na atmosfera, tinha as bases e a motivação necessárias para extrapolar esta mobilidade para o fluxo lento da superfície sólida terrestre, um salto fenomenológico maior nas Ciências da Terra. A tectónica de placas (1962-1969) progrediu a partir do conhecimento das bacias oceân...

  12. Culturele Veranderingen: het wegen waard?

    NARCIS (Netherlands)

    Mérove Gijsberts

    1993-01-01

    Verslag van een verkennend onderzoek naar de effecten van weging op de bestanden 'Culturele Verkenningen'. In kaart wordt gebracht in hoeverre er sprake is van selectieve non-respons in de databestanden. Het verschijnsel non-respons wordt nader belicht, evenals het begrip 'wegen',

  13. Sinonasal Wegener's granulomatosis: CT characteristics

    International Nuclear Information System (INIS)

    Benoudiba, F.; Marsot-Dupuch, K.; Rabia, Hadj M.; Lasjaunias, P.; Cabanne, J.; Bobin, S.

    2003-01-01

    Wegener's granulomatosis (WG) is a severe and potentially lethal granulomatosis. Even though no specific radiological criteria exist, CT may suggest the correct diagnosis at an early stage. Recent improvement in the prognosis is related to earlier diagnosis, allowing the initiation of efficient and specific treatment before any severe complications occur. We reviewed a series of WG cases in order to establish the CT diagnostic criteria. (orig.)

  14. Echocardiographic findings in patients with Wegener granulomatosis.

    Science.gov (United States)

    Oliveira, Guilherme H M; Seward, James B; Tsang, Teresa S M; Specks, Ulrich

    2005-11-01

    To describe the spectrum and clinical implications of echocardiographic findings associated with Wegener granulomatosis. We retrospectively reviewed the clinical records and echocardiographic data of consecutive patients with confirmed Wegener granulomatosis referred to the echocardiography laboratory during the 21-year period from 1976 through 1997. Of the 85 patients Identified as having confirmed Wegener granulomatosis, 73 (86%) were found to have echocardiographic abnormalities. In 26 (36%) of these 73 patients, lesions appeared directly related to Wegener granulomatosis. We found regional wall motion abnormalities in 17 (65%) of these 26 patients. Left ventricular systolic dysfunction with decreased ejection fraction was found in 13 patients (50%) and pericardial effusion in 5 patients (19%). Other findings Included valvulitis, left ventricular aneurysm, and a large intracardlac mass. A significantly increased mortality rate was observed among patients who had cardiac involvement of Wegener granulomatosis found by echocardiography. We found a high frequency of echocardiographic abnormalities that appear to be related to Wegener granulomatosis and associated with Increased mortality. Because cardiac involvement in Wegener granulomatosis often is silent and associated with Increased morbidity and worse prognosis, echocardlographic screening of patients with active Wegener granulomatosis may be of clinical value.

  15. Why turbulence dominates the atmosphere and hydrosphere? (Alfred Wegener Medal Lecture)

    Science.gov (United States)

    Zilitinkevich, Sergej

    2015-04-01

    It is widely recognised that in very stable stratifications, at Richardson numbers (Ri) exceeding the critical value Ric ~ 0.25, turbulence inevitably decays and the flow becomes laminar. This is so, indeed, in the low-Reynolds-number (Re) flows, e.g., in some laboratory experiments; but this is by no means always the case. Air flows in the free atmosphere and water currents in deep ocean are almost always turbulent in spite of the strongly supercritical stratifications, with typical values of Ri varying in the interval 10 Ric the familiar 'strong-mixing turbulence' regime, typical of boundary-layer flows and characterised by the practically invariable turbulent Prandtl number PrT ~ 1 (the so-called 'Reynolds analogy'), gives way to a previously unknown 'wave-like turbulence' regime, wherein PrT sharply increases with increasing Ri (rather than to the laminar regime as is often the case in lab experiments). It is precisely the wave-like turbulence that dominates the free flows in the atmosphere and ocean. Modellers have long been aware that the turbulent heat transfer in the free atmosphere/ocean is much weaker than the momentum transfer. Our theory gives authentic formulation for this heuristic rule and provides physically grounded method for modelling geophysical turbulence up to very stable startifications.

  16. The three lost millennia of the last deglaciation (Alfred Wegener Medal Lecture)

    Science.gov (United States)

    Bard, Edouard

    2013-04-01

    Looking back more than thirty years, climate history over the last period of deglaciation was seen to portray a smooth transition between the last glacial maximum (LGM) centered around 18,000 years ago (based on radiocarbon), and the beginning of the Holocene at about 10,000 years before present. At that time, the renowned CLIMAP group used the stratigraphy available to reconstruct the glacial world by averaging paleothermometric data over a wide time window, ranging between at least 14,000 and 24,000 yr BP, over which period climate was assumed to be rather stable. Even if northern European pollen records showed several phases of vegetation shift, the exact duration and spatial coverage of these shifts was unknown and their climatic significance was not well-enough understood to be separated from other biological effects, such as plant migration following ice-sheet demise. Significant progress came from mass spectrometry developments applied to isotope geochronology in the mid- and late- 1980s. This allowed the precise analysis of radiocarbon on small samples such as foraminifera in marine sediments and enabled the measurement of U-Th ages for accurate dating of corals and speleothems. These technological improvements permitted meaningful comparisons between proxy records from the various archives originating from all latitudes and longitudes. Today, it is clear that the old LGM time window corresponds to a period of more than ten millennia during which there was significant climate variability, including a prominent cooling event at the beginning of the deglaciation. This cooling event is known as the 'Oldest Dryas' by palynologists, as 'Heinrich Event #1' (H1) by paleoceanographers, and has even been dubbed the 'Mystery Interval' by prominent authors as they puzzled while attempting to synthesize and interpret its records. The H1 drastic cooling, attributed to a pulse-like injection of ice and meltwater into the North Atlantic, was first evidenced in 1987 in sediments from the Iberian Margin. Three years later, significant improvements of the radiocarbon calibration demonstrated that about three millennia were missing from the deglaciation record. Accordingly, the LGM mean age was pushed from 18,000 to 21,000 yr BP, the midpoint of H1 was shifted from 13,500 to 16,000 yr BP, and the beginning of the Holocene was repositioned at about 11,500 yr BP. This new climate chronology was subsequently confirmed by counting 'cryovarves' within the GRIP and GISP2 Greenland ice cores. These studies have since been complemented by many other records from polar ice, marine and lacustrine sediments and cave speleothems. In addition to extending the chronology by three additional millennia, improvement also arose from the quality of the new geological archives. These archives have allowed studies at much higher resolution than was previously achieved in the framework of CLIMAP, which included many records based on deep-sea cores characterized by low sedimentation rate, and thus very susceptible to smoothing processes such as bioturbation. In addition, analytical geochemistry has only recently provided techniques adapted to the production of high-resolution time series of various proxies based on elemental ratios, on organic compounds or on stable and radiogenic isotopes. More than a dozen years after the H1 discovery, the same Iberian Margin sediments were used to show that H1 comprised at least two phases, H1a and H1b, based on ice rafted debris (IRD) and other proxies. It is now recognized that the entire H1 event (H1 sensu lato) is a three millennia-long period (ca. 17,500 to 14,500 yr BP). To illustrate the progress in this research field, I will review the key records that can be used to document the complex nature of this episode. The H1 (s.l.) included several phases of intense cooling, of precipitation changes - notably at low latitudes and in the Asian monsoon area, of retreat and decay of glacial ice-sheets - as evidenced in sediments collected in river mouths, and of sea-level rise as recorded in corals from Tahiti and Barbados. Various isotopic proxies of deep-sea ventilation have been used to identify variations during the H1 sub-phases of the Meridional Overturning Circulation (MOC), indicating that ocean heat transport was involved in the observed climate fluctuations. The various records documenting different climate parameters at many locations over the Earth can also be used in meaningful comparison with numerical model simulations performed in a transient mode. Collectively, these works allow to estimate the phase relationships between the causes (insolation and the greenhouse effect) and the often abrupt responses of the various components of the climate system, such as the atmosphere, oceans and ice sheets. Although these studies concern a naturally-occurring global warming that took place over a long time period, useful parallels will be drawn with the evolution of modern climate. In fact, the phase relationships between forcings (such as greenhouse gases and solar input) and changes in regional and global temperatures are also at the heart of modern global climate change. As for early deglaciation, the ocean can modulate warming regionally, thereby delaying, or even temporarily masking, long-term changes. Climate changes over the last century have been smaller in magnitude than those of the last deglaciation. Fortunately for us, there has been no recent collapse of gigantic ice masses such as the Laurentian and Fennoscandian ice sheets. However, most climate models show a 20 to 40% reduction of the MOC during the 21st century. Even if this change exerts only a minor influence on the projected magnitude of global warming, such a slowdown in ocean circulation change is generally sufficient to reduce the simulated warming over the North Atlantic with a resulting impact on adjacent continents, including Europe.

  17. Alfred Russel Wallace deserves better.

    Science.gov (United States)

    Lloyd, David; Wimpenny, Julian; Venables, Alfred

    2010-09-01

    During 2009, while we were celebrating Charles Darwin and his The origin of species, sadly, little was said about the critical contribution of Alfred Russel Wallace (1823-1913) to the development of the theory of evolution. Like Darwin, he was a truly remarkable nineteenth century intellect and polymath and, according to a recent book by Roy Davies (The Darwin conspiracy: origins of a scientific crime), he has a stronger claim to the Theory of Evolution by Natural Selection than has Darwin. Here we present a critical comparison between the contributions of the two scientists. Sometimes referred to as 'The other beetle-hunter' and largely neglected for many decades, Wallace had a far greater experience of collecting and investigating animals and plants from their native habitats than had Darwin. He was furthermore much more than a pioneer biogeographer and evolutionary theorist, and also made contributions to anthropology, ethnography, geology, land reform and social issues. However, being a more modest, self-deprecating man than Darwin, and lacking the latter's establishment connections, Wallace's contribution to the theory of evolution was not given the recognition it deserved and he was undoubtedly shabbily treated at the time. It is time that Wallace's relationship with Darwin is reconsidered in preparation for 2013, the centenary of Wallace's death, and he should be recognized as at least an equal in the Wallace-Darwin theory of evolution.

  18. Wegener Granulomatosis: Otologic Manifestation as First Symptom.

    Science.gov (United States)

    Costa, Carla Fabiane da; Polanski, Jose Fernando

    2015-07-01

    Introduction Wegener granulomatosis is a systemic vasculitis affecting small and medium-sized vessels of the upper and lower respiratory tract and kidneys. Objective To describe a case of Wegener disease with atypical manifestation. Resumed Report We describe the case of a 50-year-old woman with chronic otitis media and sensorineural hearing loss as the primary symptoms, without other manifestations. Conclusion In cases of acute ear manifestations with or without hearing loss and with poor response to usual treatments, Wegener granulomatosis should be included among the possible etiologies. After adequate diagnoses and treatment of this rare disease, there was favorable evolution.

  19. Wegener Granulomatosis: Otologic Manifestation as First Symptom

    Directory of Open Access Journals (Sweden)

    Costa, Carla Fabiane da

    2014-11-01

    Full Text Available Introduction Wegener granulomatosis is a systemic vasculitis affecting small and medium-sized vessels of the upper and lower respiratory tract and kidneys. Objective To describe a case of Wegener disease with atypical manifestation. Resumed Report We describe the case of a 50-year-old woman with chronic otitis media and sensorineural hearing loss as the primary symptoms, without other manifestations. Conclusion In cases of acute ear manifestations with or without hearing loss and with poor response to usual treatments, Wegener granulomatosis should be included among the possible etiologies. After adequate diagnoses and treatment of this rare disease, there was favorable evolution.

  20. MRI appearance of pulmonary Wegener`s granulomatosis with concomitant splenic infarction

    Energy Technology Data Exchange (ETDEWEB)

    Kalaitzoglou, I.; Drevelengas, A.; Palladas, P. [Department of Radiology, `G. Papanikolaou` General Hospital, Thessaloniki (Greece); Asimaki, A. [Department of Pathology, `G. Papanikolaou` General Hospital, Thessaloniki (Greece)

    1998-03-27

    The MRI appearance of pulmonary lesions in a patient with Wegener`s granulomatosis is presented. Pulmonary involvement was characterized by multiple solid and cavitated nodules connected to vessels. Transbronchial biopsy demonstrated typical findings of granuloma. The spleen presented diffuse low signal intensity and an enhancing capsule on T1-weighted images, and inhomogeneously high signal intensity on T2-weighted images. This appearance of diffuse infarction could result from the vasculitis caused by Wegener`s disease. (orig.) With 5 figs., 14 refs.

  1. Deoxyspergualin in relapsing and refractory Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Flossmann, O; Baslund, B; Bruchfeld, A

    2008-01-01

    OBJECTIVES: Conventional therapy of Wegener's granulomatosis with cyclophosphamide and corticosteroids is limited by incomplete remissions and a high relapse rate. The efficacy and safety of an alternative immunosuppressive drug, deoxyspergualin, was evaluated in patients with relapsing or refrac......OBJECTIVES: Conventional therapy of Wegener's granulomatosis with cyclophosphamide and corticosteroids is limited by incomplete remissions and a high relapse rate. The efficacy and safety of an alternative immunosuppressive drug, deoxyspergualin, was evaluated in patients with relapsing...... or refractory disease. METHODS: A prospective, international, multicentre, single-limb, open-label study. Entry required active Wegener's granulomatosis with a Birmingham vasculitis activity score (BVAS) > or =4 and previous therapy with cyclophosphamide or methotrexate. Immunosuppressive drugs were withdrawn......-threatening (> or = grade 3) treatment-related adverse events occurred in 24 (53%) patients mostly due to leucopaenias. CONCLUSIONS: Deoxyspergualin achieved a high rate of disease remission and permitted prednisolone reduction in refractory or relapsing Wegener's granulomatosis. Adverse events were common but rarely led...

  2. Supraglottic stenosis in localized Wegener granulomatosis.

    Science.gov (United States)

    Belloso, Antonio; Estrach, Cristina; Keith, Andrew O

    2008-07-01

    We present what we believe is the first reported case of a patient with supraglottic stenosis secondary to Wegener granulomatosis. The diagnosis was unclear initially because the biopsy results were nonspecific, but a finding of an elevated cytoplasmic-pattern antineutrophil cytoplasmic antibody (c-ANCA) level established the diagnosis of localized supraglottic Wegener granulomatosis. Wegener granulomatosis is characterized by necrotizing vasculitis that is localized predominantly to the kidneys and the upper and lower airways. In the airways, subglottic involvement is well documented, but to the best of our knowledge, supraglottic stenosis has not previously been described. Localized forms of Wegener granulomatosis are characterized by limited disease that involves only the upper airway. The diagnosis in localized forms is complex because histology is diagnostic in only 50% of cases, and only 60% of patients have a positive c-ANCA level. We discuss the diagnostic criteria and management strategies for these localized forms.

  3. Rituximab for severe refractory pediatric Wegener granulomatosis.

    Science.gov (United States)

    Patel, Aarat M; Lehman, Thomas J A

    2008-10-01

    We describe a case of pediatric Wegener granulomatosis initially treated with cyclophosphamide and oral corticosteroids resulting in remission for 5 years. Of note in this case is relapse with severe pulmonary disease treated with multiple regimens, all unsuccessful. Patient achieved remission with rituximab infusion therapy. This demonstrates how rituximab may be beneficial for childhood-onset Wegener granulomatosis unresponsive to conventional therapy. The case is followed by a review of the current treatment options.

  4. Wegener granulomatosis--rare case presentation.

    Science.gov (United States)

    Bande, Uday; Baligar, Basavaraj; Terdal, Nandish

    2012-10-01

    Wegener granulomatosis is often misdiagnosed as pneumonia and most common cause for bilateral lung infiltrates' are bacterial, viral, pneumocystis jiroveci infection. We describe a 35 year old female with 15 days history of nasal obstruction, breathlessness and fever. Investigations in this patient revealed chronic necrotizing vasculitic and granulomatous lesion in nasal biopsy, vasculitic pauciimmune glomerulonephritis in renal biopsy, serology test was positive for C-ANCA, nodular with cystic lesion in CT-thorax. All these findings confirmed the diagnosis of Wegener granulomatosis.

  5. CT study of intracionial Wegener's Granulomatosis

    International Nuclear Information System (INIS)

    Yago, M.D.; Torres, T.; Martinez, G.; Lopez, A.; Barrena, R.

    1995-01-01

    Wegener granulamatosis is a multi systemic necrotizing granulomatous vasculitis distinguished from others by its predilection to affect the respiratory tract and the kidneys. Nervous system involvement occurs in 25% of cases, and the most common neurological manifestation is mono neuritis multiplex. However, primary affectation of CNS in an unusual manifestation. We report a case of Wegener Granulomatosis with almost unique neurological manifestation. CT imaging findings of meningeal involvement and retro-orbital pseudotumor are presented. 12 refs

  6. MRI of the nasal cavity, the paranasal sinuses and orbits in Wegener`s granulomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Muhle, C. [Kiel Univ. (Germany). Dept. of Diagnostic Radiology; Reinhold-Keller, E. [Rheumaklinik Bad Bramstedt (Germany). Dept. of Medicine]|[Medical Univ. Luebeck (Germany). Dept. of Rheumatology; Richter, C. [Rheumaklinik Bad Bramstedt (Germany). Dept. of Medicine]|[Medical Univ. Luebeck (Germany). Dept. of Rheumatology; Duncker, G. [Kiel Univ. (Germany). Dept. of Ophthalmology; Beigel, A. [Dr. Horst-Schmidt-Kliniken, Wiesbaden (Germany). ENT Clinic; Brinkmann, G. [Kiel Univ. (Germany). Dept. of Diagnostic Radiology; Gross, W.L. [Rheumaklinik Bad Bramstedt (Germany). Dept. of Medicine]|[Medical Univ. Luebeck (Germany). Dept. of Rheumatology; Heller, M. [Kiel Univ. (Germany). Dept. of Diagnostic Radiology

    1997-05-01

    The purpose of this study was to evaluate diagnostic MRI criteria in Wegener`s granulomatosis of the nasal cavity, the paranasal sinuses and orbits. Between March 1991 and January 1996, 62 patients with biopsy-proven Wegener`s granulomatosis were studied with T1- and T2-weighted spin-echo (SE) sequences. In 32 patients coronal postcontrast T1-weighted images were obtained. Mucosal thickening of the nasal cavity and paranasal sinuses was demonstrated as high-intensity lesions on T2-weighted SE sequences in 57 patients (92%). Of this group, inflammatory granulomatous tissue was found on biopsy in 30 patients (48%) in the nasal cavity and in 4 patients (6%) in the paranasal sinuses. In 23 patients (37%) biopsy revealed unspecific inflammatory changes without evidence of granulomatous tissue. In 14 patients (23%) granulomas were depicted as low-signal intensity lesions on T1- and T2-weighted SE sequences in the paranasal sinuses and orbits. In 5 patients (8%) osseous destruction was found. After gadolinium injection, 12 of 14 granulomas showed inhomogeneous signal enhancement. In two granulomas no enhancement was found. The MRI technique is helpful in the diagnosis of patients with Wegener`s granulomatosis. In the initial inflammatory process of Wegener`s granulomatosis, it is not possible to differentiate between mucosal inflammation and granulomatous tissue in MRI. In the later stage of granulomatous transformation, granulomas can be depicted as low-signal-intensity lesions. Therefore, Wegener`s granulomatosis should be included in the differential diagnosis of patients with low-signal-intensity lesions on T1- and T2-weighted SE sequences of the nasal cavity, paranasal sinuses and orbits. (orig.)

  7. Tracheal Stenosis Because of Wegener Granulomatosis Misdiagnosed as Asthma.

    Science.gov (United States)

    O'Hear, Kelley E; Ingrande, Jerry; Brodsky, Jay B; Morton, John M; Sung, Chih-Kwang

    2016-05-15

    We describe a patient with Wegener granulomatosis whose complaint of wheezing was incorrectly attributed to asthma. Anesthesiologists must recognize that tracheal stenosis is extremely common in Wegener granulomatosis and can mimic other causes of wheezing.

  8. Treatment of orbital inflammation with rituximab in Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Baslund, Bo; Wiencke, Anne Katrine; Rasmussen, Niels

    2012-01-01

    To study the efficacy of rituximab therapy for the treatment of orbital inflammation in patients with Wegener's granulomatosis (WG).......To study the efficacy of rituximab therapy for the treatment of orbital inflammation in patients with Wegener's granulomatosis (WG)....

  9. Forced Migration as Public Relations Process? Lothar B. Kalinowsky and the Trans-Atlantic Transfer of Electroconvulsive Therapy.

    Science.gov (United States)

    Stahnisch, Frank W

    2016-01-01

    Research in biological psychiatry during the first half of the 20 th century was based upon a wide range of interrelated disciplines, including neurology, neuroanatomy, neuropathology, and experimental biology. The work of German-American psychiatrist and neurologist Lothar B. Kalinowsky (1899-1992) is taken here as an example of how such fields could be combined to produce a highly innovative and multidimensional research program in clinical neuroscience. Kalinowsky functioned exceptionally well in both scientific and clinical cultures despite the marked contextual differences between the Charité in Berlin and his later workplace in New York's Columbia Medical School. The innovative ideas exemplified by Kalinowsky's efforts, however, sometimes amounted to a dubious advantage for émigré clinical neuroscientists: they easily led to incommensurable scientific views, and sometimes even resulted in the marginalization of the innovator from existing research programs.

  10. 'A Berlin psychiatrist with an American passport': Lothar Kalinowsky, electroconvulsive therapy and international exchange in the mid-twentieth century.

    Science.gov (United States)

    Rzesnitzek, Lara

    2015-12-01

    The emigration of Lothar Kalinowsky (1899-1992) might, at first glance, seem to be a history of coincidence and twists of fate, but it is shown to be a truly entangled and intertwined history and story. The international introduction of electroconvulsive therapy was not only closely involved with the political, scientific and economic conditions during World War II, but the story of Kalinowsky's relevance to it emerges from competing stories, told differently in Europe and the USA - and by Kalinowsky himself. Tracing these stories up to the end of the 1960s reveals Kalinowsky as an influential inheritor and patron of Berlin Biological Psychiatry, rather than telling the history of an émigré innovator of international neuropsychiatric research. © The Author(s) 2015.

  11. Pulmonary Wegener`s granulomatosis: changes at follow-up CT

    Energy Technology Data Exchange (ETDEWEB)

    Attali, P.; Begum, R.; Ben Romdhane, H.; Brauner, M.W. [Department of Radiology, Univ. Paris XIII (France); Valeyre, D. [Department of Pneumology, Univ. Paris XIII (France); Guillevin, L. [Department of Internal Medicine, Univ. Paris XIII (France)

    1998-07-01

    The objective of this study was to assess the reversibility of pulmonary lesions in Wegener`s granulomatosis using serial CT. We reviewed the follow-up CT scans of ten treated patients with confirmed Wegener`s granulomatosis. The delay between the first evaluation before treatment and the second, on patients in clinical and biological remission, ranged from 6 to 54 months (mean 20.5 months). Follow-up CT showed a decrease in the extent of disease in all cases. Lesions disappeared completely, without scarring, in 4 of 4 ground-glass opacities, 25 of 36 nodules, and 4 of 9 pulmonary consolidations; they disappeared with residual scarring in 8 of 8 masses, 3 of 9 pulmonary consolidations, and 2 of 36 nodules. The majority of lesions disappear without scarring. Residual fibrosis may follow the occurence of masses and pulmonary consolidation. Computed tomography permits assessment of cicatricial lesions. (orig.) With 4 figs., 1 tab., 11 refs.

  12. Wegener and his Theory of Continental Drift

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 4; Issue 7. Wegener and his Theory of Continental Drift. Ramesh Chander. General Article Volume 4 Issue 7 July 1999 pp 24-41. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/004/07/0024-0041 ...

  13. De ziekte van Wegener bij 2 adolescenten

    NARCIS (Netherlands)

    van der Aa, L. B.; van der Heide, M.; Sprikkelman, A. B.; Brinkhorst, G.; Tytgat, G. A. M.; van den Berg, J. M.

    2007-01-01

    Wegener's granulomatosis was diagnosed in 2 boys, aged 17 and 16 years. The first presented with pain in the right flank, without coughing or dyspnoea. He did have peaks of fever, night sweats, weight loss, headache, and epistaxis. The second presented with progressive dyspnoea, haemoptysis,

  14. Wegener and his Theory of Continental Drift

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 10; Issue 12. Wegener and his Theory of Continental Drift. Ramesh Chander. Volume 10 Issue 12 December 2005 pp 58-75. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/010/12/0058-0075 ...

  15. Wegener s granulomatosis with granulomatous liver involvement.

    Science.gov (United States)

    Holl-Ulrich, Konstanze; Klass, Monika

    2010-01-01

    We report on a patient with biopsy proven systemic Wegener's granulomatosis (WG) with a granulomatous necrotising manifestation of WG in the liver, lung, parotid gland and skin with subsequent death of liver failure. Liver involvement in WG is an exceedingly rare, though potentially fatal, organ manifestation of WG.

  16. Wegener's granulomatosis in childhood

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, G.; Benz-Bohm, G.; Rister, M.

    1984-07-01

    Wegener's granulomatosis (WG) is a rare disease in pediatric patients. The case of a 14-year-old girl with generalized WG is described and the pediatric literature reviewed. Thirty additional cases of WG in childhood have been traced in previous studies. Diagnostic problems are discussed in the context of clinical, radiological and biopsy findings.

  17. [Wegener's granulomatosis. Apropos of a case].

    Science.gov (United States)

    el Amine el Alami, N; Nazih, N; el Fakir, Y; Mohatane, A; Jazouli, N; Kzadri, M

    1997-01-01

    A rare case of granulomatosis of Wegener is rapported in this study. One patient presented with ENT and pulmonary symptoms. The differential diagnosis with tuberculosis was raised. Based on a literature review, the authors discuss clinical, pathological and imaging features of the condition and its management.

  18. Alfred Rõude sünnipäeval / Mai Levin

    Index Scriptorium Estoniae

    Levin, Mai, 1942-

    2011-01-01

    Alfred Rõudest (15.04.1896-8.09.1968) ja tema kunstikogust, mis pärast Alfred Rõude surma jäi tema abikaasa Alide Rõude (26.05.1895-14.09.1979) valdusse, siis läks Eesti Kunstimuuseumi. Nimetatud kogu töid, mis on olnud EKM-i või on Kumu püsiekspositsioonis. Autori arvates oleks Alfred Rõude suurtööle parim monument kataloogiga varustatud suur näitus

  19. An atypical case of Wegener`s granulomatosis complicated by sepsis and coxitis; Ziarniniakowatosc Wegenera o nietypowej lokalizacji powiklana posocznica i ropnym zapaleniem stawu biodrowego

    Energy Technology Data Exchange (ETDEWEB)

    Makowski, A.; Faflik, J. [Centrum Zdrowia Matki Polki, Lodz (Poland)

    1993-12-31

    There is presented an atypical case Wegener`s granulomatosis of maxillo-nasal region without bony destruction. The case is unusual because of sepsis and purulent coxitis. The patient responded well to treatment with vincristine and cyclophosphamide. ANCA (anti-neutrophil cytoplasmic antibodies) assays have very good sensitivity and specificity for Wegener`s granulomatosis. (author). 17 refs, 2 figs.

  20. Application of computed tomography in Wegener's granulomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Nagaoka, S.; Tani, K.; Kato, K. (Yokohama City Univ. (Japan). Faculty of Medicine)

    1982-06-01

    Computed tomographic (CT) findings in four patiemts with Wegener's granulomatosis were investigated. The diagnosis of Wegener's granulomatosis was made by clinical symptoms and the histological examination of biopsied materials from the nasal mucosa, bronchus and kidney. CT findings in three patients were compatible with the clinical and laboratory manifestations of Wegener's granulomatosis. In one case, CT showed a widening of the nasal cavity, bone destruction of the ethmoid and maxillary sinus. These results suggest that CT studies are very effective to evaluate the extent of Wegener's granulomatosis and its therapeutic effect.

  1. Le Corbusier, Alfred Roth y el color

    Directory of Open Access Journals (Sweden)

    Angelica Fernández-Morales

    2014-07-01

    Full Text Available This article discusses the relationship between Le Corbusier and Alfred Roth, a member of the Paris office between 1927 and 1928. It also deals with the influence that this period had with reference to an important factor in Roth’s professional development, as in Le Corbusier’s later works: the use of colour in his architecture. This article takes the position that Roth, given his close friendship with Mondrian, was an important figure in turning Le Corbusier’s work towards greater use of primary colours and aesthetic neoplasticism.

  2. [Massive alveolar haemorrhage in Wegener's granulomatosis].

    Science.gov (United States)

    Valero-Roldán, J; Nuñez-Castillo, D; Fernández-Fígares, C; López-Leiva, I

    2014-01-01

    Wegener's granulomatosis is a systemic vasculitis with involvement of primary granulomatous upper and lower respiratory tract, glomerulonephritis and vasculitis of small vessels. The lung disease ranges from asymptomatic pulmonary nodules to pulmonary infiltrates and fulminant alveolar haemorrhage. The prognosis is poor due to kidney and respiratory failure, although the data are changing due to new treatments with glucocorticoids and cyclophosphamide. We report a case with severe lung disease, which after appropriate anamnesis, multiple tests, and optimal sequential action, the patient was diagnosed with Wegener's granulomatosis. This disease has a low incidence in the Emergency Department, where the patient history supported by the appropriate additional provides a diagnostic suspicion. It is important that the Emergency Department has the skills to manage the stability in these patients in order to resolve their symptoms. Copyright © 2013 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  3. Paranasal sinus obliteration in Wegener granulomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Paling, M.R.; Roberts, R.L.; Fauci, A.S.

    1982-08-01

    The authors report 14 cases of Wegener granulomatosis in which one or more paranasal sinuses were obliterated by bone. The maxillary antra were involved in all cases, with the other sinuses being affected less frequently. These changes are thought to result from chronic bacterial sinusitis superimposed on the granulomatous vasculitic process. Computed tomography dramatically demonstrated the bone changes, consisting of a combination of sinus wall thickening and trabeculated new bone formation within the sinuses.

  4. Kidney involvement in a Wegener granulomatosis case.

    Science.gov (United States)

    Cavoli, Gioacchino Li; Ferrantelli, Angelo; Bono, Luisa; Tortorici, Calogera; Passantino, Rita; Rotolo, Ugo

    2012-01-01

    Wegener Granulomatosis is a systemic Anti-Neutrophil Cytoplasmic Autoantibody-associated Vasculitis, affecting small-to-medium vessels. Clinical presentation with simultaneous involvement of kidney and upper and lower respiratory tract is unusual. We report an instructive case of WG, analyzing clinical course, laboratory, and radiological features, kidney, lung, and larynx histological pictures. Besides renal biopsy, nephrology team performed larynx and lung biopsies because of unusual clinical presentation, computed tomography chest examination, and relevant malignancy risk regarding following immunosuppressant therapy.

  5. Granulomatose de Wegener: relato de caso Wegener's granulomatosis: a case report

    Directory of Open Access Journals (Sweden)

    Carlos E. B. Rezende

    2003-03-01

    Full Text Available A Granulomatose de Wegener é uma doença sistêmica, idiopática e rara, com acometimento das pequenas artérias dos tratos respiratórios superior e inferior e rins, levando à necrose e granuloma estes órgãos. Neste trabalho relatamos e discutimos o caso de uma adolescente, do sexo feminino, de apresentação inicial atípica e com evolução favorável após o diagnóstico precoce e tratamento adequados.Wegener's Granulomatosis is a rare systemic idiophatic disease. This disease has predilection for both the upper and lower respiratory tract and the kidney. In this paper we describe and discuss a case of Wegener's Granulomatosis, with atypical manifestations and favourable evolution after adequate diagnoses and treatment.

  6. Bronchoplastic procedure for an unusual indication--Wegener's granulomatosis.

    LENUS (Irish Health Repository)

    Soo, Alan

    2009-09-01

    Wegener\\'s granulomatosis (WG) is a systemic vasculitic condition that commonly affects the lung and kidneys. With improvement in medical therapy, airway complications are increasingly encountered and are difficult to manage. Here, we present a case whereby a patient presenting with airway complication is successfully treated with surgery.

  7. Diagnostic Consideration for Sinonasal Wegener's Granulomatosis Clinically Mistaken for Carcinoma

    Science.gov (United States)

    La Rosa, Cristina; Emmanuele, Carmela; Tranchina, Maria Grazia; Ippolito, Massimo; Cosentino, Sebastiano; Saita, Vincenzo; Fraggetta, Filippo

    2013-01-01

    We report a case of Wegener's granulomatosis clinically mistaken for carcinoma in a 21-year-old girl presenting with an ulcerated mass of the nasopharynx associated with enlarged laterocervical nodes. The lesion was clinically suspected as malignant on the basis of clinical and radiological findings (namely, computed tomography scan and positron emission tomography). However, multiple biopsies were not conclusive for malignancy showing histological change suggestive of Wegener's granulomatosis. A serum determination of cANCA supported the diagnosis of Wegener's granulomatosis. Clinical findings and image studies suggested an erroneous diagnosis of malignancy whereas a definitive diagnosis of Wegener's granulomatosis was achieved only after repeated biopsies thus leading to a correct therapeutic approach. The Wegener granulomatosis must be added to the list of the differential diagnoses of the masses of the nasopharynx associated with or without enlarged laterocervical nodes. PMID:24106630

  8. Incidence of granulomatosis with polyangiitis (Wegener`s) in Greenland and the Faroe Islands

    DEFF Research Database (Denmark)

    Faurschou, M; Helleberg, M; Obel, N

    2013-01-01

    Previous studies suggest that the incidence of granulomatosis with polyangiitis (Wegener's; GPA) increases along a south-north gradient in the Northern Hemisphere with an incidence of 8.0/million/year reported for the population of Northern Norway. In the present study, we assessed the incidence ...

  9. Alfred Russel Wallace's world of final causes.

    Science.gov (United States)

    Smith, Charles H

    2013-12-01

    Alfred Russel Wallace (1823-1913) is an important figure in the history of science, but there remain many questions about the nature of his world view, and how it developed. Here, Wallace's appreciation of the role of final causes in evolution is linked to some of its probable origins, with an emphasis on the influence of Alexander von Humboldt (1769-1859). The question is then asked whether a final causes-based scientific agenda might be possible, and answered by drawing attention to two current efforts in that direction by Adrian Bejan, and by the author. A sketch of the latter approach, adapted from Spinozian thinking, is given, with an empirical example involving drainage basin morphology that suggests structural influences of a final causes sort.

  10. O estilo em Alfred Döblin

    Directory of Open Access Journals (Sweden)

    Elcio Loureiro Cornelsen

    2010-01-01

    Full Text Available O objetivo do presente artigo é apresentar alguns aspectos teóricos postulados pelo escritor alemão Alfred Döblin em seus ensaios ao desenvolver sua própria concepção da obra épica na "era da técnica" à luz de questões estilísticas, propondo conceitos como "estilo cinematográfico", "despersonalização", "fantasia factual" e "fantasia cinética". Para uma delimitação conceitual em relação à noção de "estilo", serão tomadas por base as considerações de Antoine Compagnon, postuladas na obra O demônio da teoria (1999, bem como as reflexões de Walter Benjamin, presentes na resenha "A crise do romance" (1930 e no ensaio "O narrador" (1936.

  11. Selected scientific papers of Alfred Lande

    International Nuclear Information System (INIS)

    Barut, A.O.; Van der Merwe, A.; Lande, A.

    1988-01-01

    Alfred Lande (1888-1975) played a pivotal role in the development of quantum theory between 1914 and the birth of the new quantum theory in 1925. Today, physicists everywhere are familiar with his famous g factor (the reciprocal of the gyromagnetic ratio), his celebrated g formula, and his interval rule for the separation of multiplet sublevels. These seminal discoveries crowned Lande's brillant 'term analysis', in the period 1919 to 1922, of the anomalous Zeeman effect. Although spectroscopic term analysis is nowadays regarded (in the words of Lande) as 'self-evident... and the g formula as a feat of ingenuity', the present selection of papers will serve as a reminder that the g formula represented 'only a small step of applying the introduction of the g factor in the magnetic term analysis', which 'at the time... was the great breakthrough'. refs.; figs.; tabs

  12. Massive intracerebral hemorrhage associated with Wegener granulomatosis.

    Science.gov (United States)

    Ceri, Mevlut; Ortabozkoyun, Levent; Unverdi, Selman; Kirac, Mustafa; Duranay, Murat

    2012-06-01

    Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment strategies may be considered in addition to classical practices in serious organ involvement and recurrent attack. Here, we present an adult patient with WG whose disease was complicated by a massive intracerebral hemorrhage (ICH), which subsequently led to death.

  13. From Engineering Hydrology to Earth System Science: Milestones in the Transformation of Hydrologic Science (Alfred Wegener Medal Lecture)

    Science.gov (United States)

    Sivapalan, Murugesu

    2017-04-01

    Hydrologic science has undergone almost transformative changes over the past 50 years. Huge strides have been made in the transition from early empirical approaches to rigorous approaches based on the fluid mechanics of water movement on and below the land surface. However, further progress has been hampered by problems posed by the presence of heterogeneity, especially subsurface heterogeneity, at all scales. The inability to measure or map subsurface heterogeneity everywhere prevented further development of balance equations and associated closure relations at the scales of interest, and has led to the virtual impasse we are presently in, in terms of development of physically based models needed for hydrologic predictions. An alternative to the mapping of subsurface heterogeneity everywhere is a new earth system science view, which sees the heterogeneity as the end result of co-evolutionary hydrological, geomorphological, ecological and pedological processes, each operating at a different rate, which have helped to shape the landscapes that we see in nature, including the heterogeneity below that we do not see. The expectation is that instead of specifying exact details of the heterogeneity in our models, we can replace it, without loss of information, with the ecosystem function they perform. Guided by this new earth system science perspective, development of hydrologic science is now guided by altogether new questions and new approaches to address them, compared to the purely physical, fluid mechanics based approaches that we inherited from the past. In the emergent Anthropocene, the co-evolutionary view is expanded further to involve interactions and feedbacks with human-social processes as well. In this lecture, I will present key milestones in the transformation of hydrologic science from Engineering Hydrology to Earth System Science, and what this means for hydrologic observations, theory development and predictions.

  14. The Challenges of Developing a Framework for Global Water Cycle Monitoring and Prediction (Alfred Wegener Medal Lecture)

    Science.gov (United States)

    Wood, Eric F.

    2014-05-01

    The Global Earth Observation System of Systems (GEOSS) Water Strategy ("From Observations to Decisions") recognizes that "water is essential for ensuring food and energy security, for facilitating poverty reduction and health security, and for the maintenance of ecosystems and biodiversity", and that water cycle data and observations are critical for improved water management and water security - especially in less developed regions. The GEOSS Water Strategy has articulated a number of goals for improved water management, including flood and drought preparedness, that include: (i) facilitating the use of Earth Observations for water cycle observations; (ii) facilitating the acquisition, processing, and distribution of data products needed for effective management; (iii) providing expertise, information systems, and datasets to the global, regional, and national water communities. There are several challenges that must be met to advance our capability to provide near real-time water cycle monitoring, early warning of hydrological hazards (floods and droughts) and risk assessment under climate change, regionally and globally. Current approaches to monitoring and predicting hydrological hazards are limited in many parts of the world, and especially in developing countries where national capacity is limited and monitoring networks are inadequate. This presentation describes the developments at Princeton University towards a seamless monitoring and prediction framework at all time scales that allows for consistent assessment of water variability from historic to current conditions, and from seasonal and decadal predictions to climate change projections. At the center of the framework is an experimental, global water cycle monitoring and seasonal forecast system that has evolved out of regional and continental systems for the US and Africa. The system is based on land surface hydrological modeling that is driven by satellite remote sensing precipitation to predict current hydrological conditions, flood potential and the state of drought. Seasonal climate model forecasts are downscaled and bias-corrected to drive the land surface model to provide hydrological forecasts and drought products out 6-9 months. The system relies on historic reconstructions of water variability over the 20th century, which forms the background climatology to which current conditions can be assessed. Future changes in water availability and drought risk are quantified based on bias-corrected and downscaled climate model projections that are used to drive the land surface models. For regions with lack of on-the-ground data we are field-testing low-cost environmental sensors and along with new satellite products for terrestrial hydrology and vegetation, integrating these into the system for improved monitoring and prediction. At every step there are scientific challenges whose solutions are only partially being solved. In addition there are challenges in delivering such systems as "climate services", especially to societies with low technical capacity such as rural agriculturalists in sub-Saharan Africa, but whose needs for such information are great. We provide an overview of the system and some examples of real-world applications to flood and drought events, with a focus on Africa.

  15. Alfred Õunapi 36 pedagoogiaastat / Toomas Reinpõld

    Index Scriptorium Estoniae

    Reinpõld, Toomas, 1960-

    2009-01-01

    Persoonilugu Põltsamaa Ametikooli maamajanduseriala praktilise poole kutseõpetajast Alfred Õunapist, kes pälvis Eesti Põllumajandus-Kaubanduskoja ning Maaelu Edendamise Sihtasutuse eripreemia aastatepikkuse töö eest

  16. Granulomatose de Wegener – Forma limitada

    Directory of Open Access Journals (Sweden)

    I. Gil

    2002-01-01

    Full Text Available RESUMO: Doente do sexo feminino, 53 anos de idade, internada por lesões nodulares pulmonares sugestivas de doença metastática.Antecedentes de Doença de Graves e de Pyoderma gangrenosum.Biópsia pulmonar compatível com Granulomatose de Wegener.REV PORT PNEUMOL 2002; VIII (1: 87-93 ABSTRACT: Female, 53 years old, with nodular lung lesions suggesting metastatic disease.This patient had clinical antecedents of Graves disease and Pyoderma gangrenosum.The lung biopsy was compatible with Wegener’ Granulomatosis.REV PORT PNEUMOL 2002; VIII (1: 87-93 Palavras-chave: granulomatose, Wegener, forma limitada, vasculite, Key-words: granulomatosis, Wegener, limited, vasculitis

  17. A rare presentation of renal Wegener granulomatosis in a child.

    Science.gov (United States)

    D'Hauwe, Riet; Lerut, Evelyne; Breysem, Luc; Smet, Marleen

    2011-09-01

    We present a rare case of Wegener granulomatosis of the kidney in childhood. The diagnosis was suggested on imaging due to a combination of clinical symptoms, the lack of improvement with antibiotic therapy, and the absence of signs of inflammation on renal imaging. It was confirmed by histological examination following biopsy. The features and appearance of renal Wegener granulomatosis are described, and the differential diagnosis for a childhood renal mass is discussed.

  18. Marathon of eponyms: 23 Wegener granulomatosis.

    Science.gov (United States)

    Scully, C; Langdon, J; Evans, J

    2012-03-01

    The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry, oral and maxillofacial medicine, oral and maxillofacial pathology and oral, oral and maxillofacial radiology and maxillofacial surgery) and particularly by hospital-centred practitioners. This series has selected some of the more recognized relevant eponymous conditions and presents them alphabetically. The information is based largely on data available from MEDLINE and a number of internet websites as noted below: the authors would welcome any corrections. This document summarizes data about Wegener granulomatosis. © 2012 John Wiley & Sons A/S.

  19. Wegener Granulomatosis Revealed by Pleural Effusion

    Science.gov (United States)

    Toffart, Anne-Claire; Arbib, François; Lantuejoul, Sylvie; Roux, Jean-François; Bland, Vincent; Ferretti, Gilbert; Diab, Samia

    2009-01-01

    Pulmonary signs are common in Wegener's granulomatosis (WG). However, an initial presentation including pleural effusion has not been described. We describe a case of WG in which pleural effusion was the first clinical manifestation. A 45-year-old man with dorsal pain presented with pleural thickening and effusion, and a visible nodule on a thoracic scan. A dense chronic inflammatory infiltrate was obtained by pleural biopsy and an open lung biopsy revealed necrotizing granulomatous vasculitis. Serologies were positive for antineutrophil cytoplasmic antibodies and antiproteinase 3 antibodies. A diagnosis of WG was conducted and the patient was started on cyclophosphamide and methylprednisolone as an initial treatment, with a favorable evolution. Although pleural effusion is rarely described in WG, this pathology must be considered in the presence of this clinical manifestation. PMID:20168982

  20. Orbital Granulomatosis With Polyangiitis (Wegener Granulomatosis)

    Science.gov (United States)

    Muller, Karra; Lin, Jonathan H.

    2014-01-01

    The pathology of granulomatosis with polyangiitis (GPA), formerly Wegener granulomatosis, typically features a granulomatous and sometimes necrotizing vasculitis targeting the respiratory tract and kidneys. However, orbital involvement occurs in up to 60% of patients and is frequently the first or only clinical presentation in patients with systemic or limited forms of GPA. Orbital GPA can cause significant morbidity and potentially lead to complete loss of vision and permanent facial deformity. Fortunately, GPA is highly responsive to medical treatment with corticosteroids combined with cyclophosphamide or, more recently, rituximab. Therefore, it is imperative for this disease to be accurately diagnosed on orbital biopsy and distinguished from other histologically similar orbital lesions. Herein, we review the clinical and pathologic findings of orbital GPA, focusing on the differentiation of this disease from other inflammatory orbital lesions. PMID:25076302

  1. Wegener Granulomatosis Revealed by Pleural Effusion

    Directory of Open Access Journals (Sweden)

    Anne-Claire Toffart

    2009-01-01

    Full Text Available Pulmonary signs are common in Wegener's granulomatosis (WG. However, an initial presentation including pleural effusion has not been described. We describe a case of WG in which pleural effusion was the first clinical manifestation. A 45-year-old man with dorsal pain presented with pleural thickening and effusion, and a visible nodule on a thoracic scan. A dense chronic inflammatory infiltrate was obtained by pleural biopsy and an open lung biopsy revealed necrotizing granulomatous vasculitis. Serologies were positive for antineutrophil cytoplasmic antibodies and antiproteinase 3 antibodies. A diagnosis of WG was conducted and the patient was started on cyclophosphamide and methylprednisolone as an initial treatment, with a favorable evolution. Although pleural effusion is rarely described in WG, this pathology must be considered in the presence of this clinical manifestation.

  2. Fulminant Wegener's granulomatosis: a case report.

    Science.gov (United States)

    Dinić, Miroslav Z; Sekulović, Lidija Kandolf; Zolotarevski, Lidija; Zecević, Rados D

    2013-09-01

    Granulomatosis Wegener is anti-neutrophil cytoplasmic antibodies (ANCAs)-associated systemic vasculitis of unknown etiology. It is manifested as granulomatous necrotizing inflammation of the upper and lower parts of the respiratory tract, glomerulonephritis and systemic vasculitis involving most frequently the skin and oral mucous membrane. Sera markers of this disease are c-ANCA and pANCA. We presented a female patient aged 52 years with purpuric spots that had appeared on the lower legs ten months before admission to our hospital. The disease ran an aggressive course, and a month before admission hemorrhagic bullae, skin ulcers, hoarseness, dyspnea, generalized arthralgia, fatigue and fever had rapidly developed. Histopathological examination of a skin sample revealed necrotizing vasculitis, so that sera markers concentrations were elevated (c-ANCA, p-ANCA). There was a perforation of the nasal septum found on rhinoscopy. During hospitalization acute abdominal pain occurred, a possible tumor in the small intestine and possible granulomas in the liver were seen by multislice computed tomography (MSCT) examination, with normal findings on the lungs and kidneys. The treatment started with methylprednisolone: 500 mg/d i.v. infusion for consecutive 3 days, then 60 mg/d. On exploratory laparotomy small bowel perforation and diffuse peritonitis were found. Unstable in the postoperative period, the patient died on the day 12 of hospitalization. The reported patient was with fulminant Wegener's granulomatosis, dominantly with skin changes and with gastrointestinal manifestation. This case accents the need for rapid systemic clinical evaluation in a severely ill patient with unclear diagnosis.

  3. Wegener's granulomatosis in childhood

    Energy Technology Data Exchange (ETDEWEB)

    McHugh, K.; Manson, D. (Hospital for Sick Children, Toronto, ON (Canada). Dept. of Diagnostic Imaging); Eberhard, B.A.; Shore, A.; Laxer, R.M. (Hospital for Sick Children, Toronto, ON (Canada). Div. of Rheumatology)

    1991-12-01

    The authors reviewed the medical histories and radiological examinations of five pediatric patients with a histologic diagnosis of Wegener's granulomatosis (WG) seen over a six year period in whom a total of 22 thoracic CT scans were performed. Involvement of both the upper and lower respiratory tracts was seen in all patients at presentation. One patient had subglottic stenosis necessitating tracheotomy. Pulmonary hemorrhage occurred in three patients at initial diagnosis. Classic cavitary lung nodules were seen in two patients - one at initial presentation, the other at relapse. The plain radiographic lower respiratory tract manifestations of pediatric WG were protean both at initial presentation and during follow up. Similarly, disease expression was highly variable on thoracic CT examinations but, overall multifocal parenchymal infiltrates with or without small peripheral nodules were the commonest thoracic CT manifestations. As a consequence of cytotoxic and corticosteroid therapy the long-term prognosis of WG has improved considerably in recent years. Knowledge of the varied patterns of the primary disease and potential for iatrogenic complications are necessary for successful radiologic assessment of pediatric patients with WG. (orig.).

  4. Imaging diagnosis of orbital Wegener granulomatosis

    Science.gov (United States)

    Yang, Bin; Yin, Zhijian; Chen, Shuai; Yuan, Feng; Zhao, Wei; Yang, Yaying

    2017-01-01

    Abstract Introduction: Wegener granulomatosis (WG) is a rare idiopathic autoimmune disease causing necrotizing granulomatous vasculitis. Whether as the first symptom or as part of systemic changes, ocular manifestations in WG patients are not specific. Any part of the eyes can be affected, with the anterior segment and orbit most commonly involved. So, early diagnosis and treatment are essential for controlling the progression of the disease and improving the quality of life for patients. Clinical findings/Patient concerns: Here we present a rare case of orbital WG of a 22-year-old woman was admitted to the hospital because of intense pain associated with decreased visual acuity in her right eye since 1 day. She had been previously diagnosed with WG at our hospital. Imaging diagnosis: Orbital computed tomography imaging showed diffuse swelling of intraorbital muscles, and space-occupying lesions were present in both eyes. Most postnasal anatomical structures were absent, appearing as a massive cavity shadow. Orbital magnetic resonance imaging showed a shadow of orbital soft tissues. Conclusion: WG is a serious, fatal disease. Early diagnosis and treatment are essential for controlling the progression of the disease and improving the quality of life for patients. PMID:28591026

  5. Apostle of Freedom: Alfred Adler and His British Disciples

    Science.gov (United States)

    Hirsch, Pam

    2005-01-01

    The psychology of Alfred Adler is traditionally considered to be one of the three so-called in-depth or psychoanalytic therapies, the other two being the theories of Sigmund Freud and Carl Gustav Jung. This article demonstrates that Adler's Individual Psychology was especially influential on teachers in Vienna between the two world wars. There…

  6. Alfred Kongo, intiimse maalilaadi meister / Juta Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Juta, 1952-

    2001-01-01

    Alfred Kongost, tema loomingust. A. Kongo 95. sünniaastapäeva tähistav näitus Adamson-Ericu muuseumis 10. X-11. XI ja 9. XI toimub mälestusteõhtu. Näha saab Tiina Pargi 1984. a. filmi A. Kongost

  7. Sir Alfred Bray Kempe–An Amateur Kinematician

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 3. Sir Alfred Bray Kempe-An Amateur Kinematician. A K Mallik. General Article Volume 16 Issue 3 March 2011 pp 204-218. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/016/03/0204-0218 ...

  8. Kurt Alfred Georg Mendelssohn 7 January 1906 - 18 September 1980

    International Nuclear Information System (INIS)

    Shoenberg, D.

    1983-01-01

    The life, career and main themes of scientific achievement of Kurt Alfred Georg Mendelssohn are described in detail under the headings: early life in Germany, scientific work, early work in Germany, superconductivity, transport properties of metals, liquid helium, medical physics, Oxford and later life. (U.K.)

  9. Alfred Jules Aver's induction and Marxian historical evolution: It's ...

    African Journals Online (AJOL)

    Alfred Jules Aver's induction and Marxian historical evolution: It's lessons for the current economic global crisis. ... Economic liberalism, political manipulation and gross capitalism have been given as the major causes of the present situation in the world economy. It is on this touchstone that we tried to examine the Marxian ...

  10. An unusual presentation of Wegener disease of the cervix: presenting as cervical cancer.

    Science.gov (United States)

    Oladipo, Abi; Sathiyathasan, Sahathevan; Thomas, Syamala; Jeyanthan, Kannapar; Hakeem-Habeeb, Yewnade

    2011-10-01

    : Wegener granulomatosis is a rare autoimmune disease of unknown cause. It commonly affects the respiratory tracts, lungs, and kidneys.Involvement of the uterine cervix is rare, with only 4 previously published cases in the literature. : This is a case report. : We describe the unusual presentation of Wegener granulomatosis involving the uterine cervix, presenting as cervical cancer. : A review of previously published cases of Wegener granulomatosis involving the uterine cervix is presented.We report the first case of Wegener granulomatosis involving the cervix without antecedent diagnosis or treatment of Wegener granuloma in any other organ.

  11. [Wegener granulomatosis - otologic, nasal, tracheobronchial and pulmonary involvement].

    Science.gov (United States)

    Figueiredo, Sandra; Leal, Laurentino Mendes; Morais, António; Magalhães, Adriana; Oliveira, Teresa; Hespanhol, Venceslau; Dias, Carlos; Fernandes, Gabriela

    2009-01-01

    Wegener granulomatosis is a rare systemic idiopathic disease characterized by involvement of small vessels - medium and small arteries, venules, arterioles and ocasionally large arteries. This disease has predilection for the upper and lower respiratory tract and the kidney, with granulomatous inflamation and necrosis. Clinical manifestations and organ involvement of the disease vary widely. Early diagnosis and treatment may lead to a full recovery. Without treatment, Wegener's granulomatosis can be fatal. The authors present a case of a 33 year-old female, with severe disease, but with good outcome, after adequate diagnosis and treatment.

  12. Wegener granulomatosis causing compressive optic neuropathy in a child.

    Science.gov (United States)

    Aakalu, Vinay K; Ahmad, Amjad Z

    2009-01-01

    Wegener granulomatosis is an uncommon illness in children that is known to cause myriad ophthalmic complications, but it is rarely a cause of compressive optic neuropathy. A 17-year-old Hispanic boy with Wegener granulomatosis developed unilateral loss of vision, pain, and proptosis of the left eye. CT findings revealed enlargement of bilateral lacrimal glands with compression of the left optic nerve. The patient was admitted for high-dose intravenous corticosteroids and daily oral cyclophosphamide treatment. The patient's vision, pain, and proptosis improved dramatically, and he is now stable on mycophenolate mofetil and prednisone.

  13. Nephroangiography in Wegener's granulumatosis. A comparison with panarteritis nodosa.

    Science.gov (United States)

    Lundström, B; Lindqvist, B; Söderbergh, H; Wentzel, T; Hallmans, G

    1975-11-01

    Three cases of Wegener's granulomatosis with a classical course are described, 2 of which with fatal outcome in spite of immuno-suppressive therapy. Nephroangiography was performed during the oliguric or anuric phase. The appearances were similar to those encountered in glomerulonephritis and were compared with those in three cases of panarteritis nodosa. Two of these represented the classical form with intrarenal arterial aneurysms; the third was a case of the microscopic type presenting blurred intrarenal arteries with lumen variations and occlusions. These observations support the opinion that Wegener's granulomatosis nodosa are different diseases. Nephroangiography seems to be of value in their differentiation.

  14. Wegener granulomatosis-associated optic perineuritis.

    Science.gov (United States)

    Takazawa, Takanori; Ikeda, Ken; Nagaoka, Tetsuro; Hirayama, Takehisa; Yamamoto, Tatsuhiro; Yanagihashi, Masaru; Tochikubo, Tetsuo; Iwasaki, Yasuo

    2014-02-01

    INTRODUNCTION: We report two patients with optic perineuritis (OPN) and hypertrophic pachymeningitis in Wegener granulomatosis (WG). Patient 1: a 74-year-old man developed blurred vision in each eye, sequentially, over a year. In the first episode, visual acuity in the right eye was reduced to no light perception, and in the second episode, the vision in the left eye fell to 20/100. Brain and orbital magnetic resonance imaging (MRI) revealed abnormal enhancement in the meninges and the ipsilateral optic nerve sheath. T2-hyperintense lesions were found along the outer rim of the ipsilateral optic nerve. Seropositive proteinase-3-antineutrophil cytoplasmic antibody (PR3-ANCA), microhematuria and multiple pulmonary nodules suggested the diagnosis of WG. Steroid therapy was initiated 3 months after the first onset, but with no clinical response. At the 2nd episode, rapid administration of steroid ameliorated visual disturbance and MRI lesions markedly. Patient 2: a 72-year-old man developed blurred vision in each eye. Visual acuity measured no light perception in OD and 6/12 in OS. Gadolinium-enhanced MRI disclosed enhancement in the meninges and both optic nerve sheaths. T2-weighted imaging displayed hyperintense lesions along the outer rims of optic nerves. Otolaryngologic examination, seropositive PR3-ANCA and pulmonary nodules supported the diagnosis of WG. Steroid and cyclophosphamide treatment improved visual dysfunction and MRI lesions in the meninges and the optic nerve sheaths. The morphological similarity and the anatomical continuity between the meningeal and the perioptic tissues suggest that extension of granulomatous inflammation along such tissue planes accounted for visual loss in these two patients with WG.

  15. Fulminant Wegener's granulomatosis: A case report

    Directory of Open Access Journals (Sweden)

    Dinić Miroslav Ž.

    2013-01-01

    Full Text Available Introduction. Granulomatosis Wegener is anti-neutrophil cytoplasmic antibodies (ANCAs-associated systemic vasculitis of unknown etiology. It is manifested as granulomatous necrotizing inflammation of the upper and lower parts of the respiratory tract, glomerulonephritis and systemic vasculitis involving most frequently the skin and oral mucous membrane. Sera markers of this disease are c-ANCA and p-ANCA. Case report. We presented a female patient aged 52 years with purpuric spots that had appeared on the lower legs ten months before admission to our hospital. The disease ran an aggressive course, and a month before admission hemorrhagic bullae, skin ulcers, hoarseness, dyspnea, generalized arthralgia, fatigue and fever had rapidly developed. Histopathological examination of a skin sample revealed necrotizing vasculitis, so that sera markers concentrations were elevated (c-ANCA, p-ANCA. There was a perforation of the nasal septum found on rhinoscopy. During hospitalization acute abdominal pain occurred, a possible tumor in the small intestine and possible granulomas in the liver were seen by multislice computed tomography (MSCT examination, with normal findings on the lungs and kidneys. The treatment started with methylprednisolone: 500 mg/d i.v. infusion for consecutive 3 days, then 60 mg/d. On exploratory laparotomy small bowel perforation and diffuse peritonitis were found. Unstable in the postoperative period, the patient died on the day 12 of hospitalization. Conclusion. The reported patient was with fulminant Wegener’s granulomatosis, dominantly with skin changes and with gastrointestinal manifestation. This case accents the need for rapid systemic clinical evaluation in a severely ill patient with unclear diagnosis.

  16. Tracheobronchial Stenoses in Granulomatosis With Polyangiitis (Wegener's)

    Science.gov (United States)

    Girard, Charlotte; Charles, Pierre; Terrier, Benjamin; Bussonne, Guillaume; Cohen, Pascal; Pagnoux, Christian; Cottin, Vincent; Cordier, Jean-François; Guillevin, Loïc

    2015-01-01

    Abstract Tracheobronchial stenoses (TBSs) are potentially severe manifestations of granulomatosis with polyangiitis (Wegener's) (GPA) that usually respond poorly to corticosteroids and immunosuppressive agents. We describe 26 GPA patients with ≥1 tracheal (mainly subglottic, SGS) and/or bronchial stenosis(ses) (BS(s)). Sixteen patients had solitary SGS and 10 had ≥1 BS(s). The male/female sex ratio was 9:17, and the median age at GPA diagnosis was 32 years (3:13 and 28 years, respectively, for SGS patients). Antineutrophil cytoplasm antibodies were proteinase 3-positive in 65.5% of the patients (50% of those with SGS). Despite conventional GPA therapy, 62% patients experienced ≥1 stenosis relapse(s) (81% of SGS patients, for a total of 1–8 relapses per patient). None of the several systemic or endoscopic treatments prevented future relapses. Cyclophosphamide induction therapy was effective in 4/6 patients with BS(s) and in 1 patient with SGS among the 7 treated. After many relapses, rituximab achieved remission in 3/4 SGS patients. Endoscopic treatments (dilation, laser, corticosteroid injection, etc.) had only transient efficacy. Other GPA manifestations relapsed independently of TBSs. One SGS patient died of acute respiratory distress syndrome. Our findings confirmed that TBSs are severe GPA manifestations that evolve independently of other organ involvements and do not respond to conventional systemic regimens. As previously described, our population was younger and comprised more females than usual GPA patients, especially those with SGS. The small number of patients and the wide variety of local and systemic treatments prevent us from drawing definitive conclusions about the contribution of each procedure. However, cyclophosphamide seemed to effectively treat BSs, but not SGS, and rituximab may be of interest for SGS management. PMID:26266344

  17. Wegener's granulomatosis: chest computed tomography findings; Granulomatose de Wegener: aspectos na tomografia computadorizada de torax

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Evelise de Azevedo; Marchiori, Edson; Martins, Erick Malheiro Leoncio [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia]. E-mail: edmarchiori@zipmail.com.br; Souza Junior, Arthur Soares [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Hospital de Base; Cerqueira, Elza Maria F.P. de [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Ciencias Medicas. Dept. de Radiologia; Irion, Klaus L. [Pavilhao Pereira Filho, Porto Alegre, RS (Brazil); Araujo Neto, Cesar de [Bahia Univ., Salvador, BA (Brazil). Dept. de Radiologia; Souza, Rodrigo Azeredo de [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Dept. de Radiologia

    2003-03-01

    Wegeners granulomatosis is an inflammatory systemic necrotizing idiopathic vasculitis affecting mainly small vessels. In this paper we analyzed the computed tomography findings of seven patients with Wegeners granulomatosis. The most common findings were masses and nodules (71.4%), areas of ground glass attenuation (57.1%), consolidation (42.8%), halo sign (42.8%), cavitation (42.8%), interlobular septa thickening (14.2%), bronchial wall thickening (14.2%) and pleural effusion (14.2%). Although radiological findings are mostly nonspecific, computed tomography and particularly high-resolution computed tomography are important tools in the evaluation of disease activity when evaluated in association with bronchoscopy findings and clinical data. (author)

  18. Treatment of orbital inflammation with rituximab in Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Baslund, Bo; Wiencke, Anne Katrine; Rasmussen, Niels

    2012-01-01

    OBJECTIVES: To study the efficacy of rituximab therapy for the treatment of orbital inflammation in patients with Wegener's granulomatosis (WG). METHODS: Ten WG patients with orbital inflammation were included in this case-series. None had symptoms suggestive of extra-orbital disease activity...

  19. Infections and Wegener's granulomatosis - A cause and effect relationship?

    NARCIS (Netherlands)

    George, J; Levy, Y; Kallenberg, CGM; Shoenfeld, Y

    The association of infections and autoimmune disease has been noted by various authors. Several mechanisms have been proposed to explain this, with no current consensus. Wegener's granulo-matosis (WG) is an autoimmune disease involving predominantly the pulmonary and renal systems, and is associated

  20. Analysis of a cluster of cases of Wegener granulomatosis.

    Science.gov (United States)

    Albert, Daniel A; Albert, Alexis N; Vernace, Melchiore; Sebastian, Jodi K; Hsia, Elizabeth C

    2005-08-01

    Wegener granulomatosis is a chronic inflammatory autoimmune disease of unknown etiology. The sporadic occurrence, lack of familial or genetic associations, and rising incidence suggest possible exposure to environmental agents as causative for this disease. The objective of this study was to examine possible environmental triggers of Wegener granulomatosis. While conducting an environmental survey of potential precipitants of Wegener granulomatosis on a cohort of patients seen at Doylestown Hospital and at the University of Pennsylvania, we identified a cluster of cases in the Dublin, Pennsylvania, region. Through hospital records and patient contacts, we located 7 cases diagnosed in a 3-year period within a 10-mile radius of an Environmental Protection Agency (EPA) Superfund toxic waste site. The radius of inclusion represents a population of approximately 50,000 individuals. Assuming complete ascertainment of cases--which is unlikely given the methods used to acquire patients--the prevalence is 2- to 4-fold greater than the expected rate of 3 per 100,000. We identified toxins at or above "action level" within the demarcated geographic region using published data from the EPA. Furthermore, we queried patients regarding their particular chemical exposures. These patients with Wegener granulomatosis were possibly exposed to high levels of trichloroethylene (TCE), vinyl chloride, methyl tertiary-butyl ether (MTBE), dichloroethene (DCE), and chromic acid from several industrial waste sites within the area. Additionally, these patients reported a total of greater than 30 possible exposures, including the aforesaid chemical contaminants. Three of 5 patients whose water source is known had well water that exposed them to industrial runoff and necessitated EPA intervention. This data, along with other epidemiologic studies, suggest possible toxic exposures as potentially correctable risk factors for Wegener granulomatosis. We encourage clinicians to seek data that

  1. Building local participation and support for ALFRED project

    International Nuclear Information System (INIS)

    Apostol, M.; Constantin, M.; Diaconu, D.

    2016-01-01

    At the beginning of 2015, a Local Dialog Group (LDG) was set-up under the FP7 ARCADIA project, as an interface between the implementer of ALFRED demonstrator (Fostering ALfred CONstruction - FALCON consortium) and local community from Mioveni town. The paper discusses the current situation and the possible evolution of the group beyond the ARCADIA project (November 2016). The possible evolution could be the transformation in a Local Committee (LC), this fact leading to the extension of LDG.s actual role, towards a larger participation in decision making process (DMP). Aspects regarding LC construction elements as local context, mission and role, legitimacy, funding and resources, organizing mode, products and outputs, the interaction with other stakeholders, are presented in the paper. In order to describe the context, some general elements concerning the Local Committees (LCs) as tools for the communities. involvement in the DMP are also introduced. (authors)

  2. Neuropatia vasculítica na granulomatose de Wegener: relato de caso Vasculitic neuropathy in Wegener granulomatosis: case report

    Directory of Open Access Journals (Sweden)

    Hildo Azevedo Filho

    2001-06-01

    Full Text Available O acometimento neurológico no curso da granulomatose de Wegener atinge 15-50% dos pacientes, porém como sintomatologia inicial não é comentado na literatura. Relatamos o caso de uma paciente com mononeurite múltipla secundária a granulomatose de Wegener, enfocando os aspectos de antecipação do quadro neurológico em relação aos sintomas sistêmicos, a contribuição diagnóstica da biópsia do nervo sural e a boa evolução do quadro neurológico.The neurologic involvement during Wegener granulomatosis reachs 15-50% of patients, however as initial symptomatology is not commented in the literature. We describe a patient with Wegener's granulomatosis and mononeuritis multiplex, emphasizing the fact that neurologic manifestations antecipated systemic symptoms, and also focusing on the diagnostic contribution of sural biopsy and the good outcome of neurologic disease.

  3. Alfred Russel Wallace and the Antivaccination Movement in Victorian England

    OpenAIRE

    Weber, Thomas P.

    2010-01-01

    Alfred Russel Wallace, eminent naturalist and codiscoverer of the principle of natural selection, was a major participant in the antivaccination campaigns in late 19th-century England. Wallace combined social reformism and quantitative arguments to undermine the claims of provaccinationists and had a major impact on the debate. A brief account of Wallace’s background, his role in the campaign, and a summary of his quantitative arguments leads to the conclusion that it is unwarranted to portra...

  4. Cranial manifestation of Wegener's granuolomatosis: CT and MRI characteristics

    International Nuclear Information System (INIS)

    Hartmann, M.; Siebert, S.; Rohde, S.

    2006-01-01

    Wegener's granulomatosis is a rare systemic granulomatous disease which primarily involves the upper and lower respiratory tract and the kidneys. In addition the orbits, the peripheral and the central nervous system may also be affected. Computed tomography and magnetic resonance imaging have been proven to be quite useful for the detection of these lesions, for assessment of the extent of involvement, and for documentation of response to therapy. The drawback of CT and MR studies is that they lack specifity. Characteristic imaging findings for WG is a medial wall destruction of the maxillary sinus with gross thickening of the anterior and infratemporal walls with relatively low soft tissue proliferation. On T2-weighted MR images the granulomatous tissue appears markedly hypointense with dense enhancement. Although these findings are not specific, if they are obvious, Wegener's granulomatosis should be considered in the differential diagnosis. (orig.)

  5. Demonstration of Wegener's granuloma on mammography

    Energy Technology Data Exchange (ETDEWEB)

    Deininger, H.K.

    1984-08-01

    Communication about two patients with Wegener's granulomatosis of the mamma. In both cases the rare disease was detected on the occasion of a mammographic examination. The results of the mammography could cause misinterpretations, e.g. it might be mistaken for an advanced mamma carcinoma. Up to now, the manifestation of a Wegener's disease of the female breast was neither mentioned in collective statistics of more than 324 cases nor could it be found in examining the publications of additional 231 cases. Both patients showed an unusual course of the disease with a slow progression as well as an unimportant affection of the respiratory tract. The regression of the tumor like lesions in the breast was remarkable. 8 figs.

  6. Development of granulomatosis with polyangiitis (Wegener): listen to the patient.

    Science.gov (United States)

    Kandiah, David A

    2011-08-01

    Patients with rare or complex conditions may sometimes come up with the right diagnosis because of their previous exposure to the condition. This may be due to their knowledge of their family history or even concerns based on their exposure to information from electronic or paper repositories. In this case report, a 40-year-old woman who already had 1 rare condition of lymphangioleiomyomatosis developed breast "abscesses" that did not respond to traditional surgical debridement and antibiotics. She wondered if the lesions could be related to granulomatosis with polyangiitis (Wegener) as she had a strong family history of this condition. Subsequent investigations confirmed the diagnosis. Her response to treatment was complete. Breast lesions in granulomatosis with polyangiitis (Wegener) have been infrequently reported in the literature but should be considered in poorly healing lesions, despite the absence of other more typical symptoms at the time of presentation.

  7. [Recurrent pericarditis as an initial manifestation of Wegener's granulomatosis].

    Science.gov (United States)

    Leroy, S; Gaudebout, N; Lanteme, P; Seve, P

    2014-02-01

    Recurrent pericarditis occur in around a quarter of patients after a first episode of acute pericarditis. Most of the cases are idiopathic or viral pericarditis or post-pericardial injury syndromes. Recurrent pericarditis are most likely to occur in patients with known systemic lupus erythematosus or rheumatoid arthritis but are rare in other systemic auto-immune diseases. We report here an unusual case of a patient with a 5-year history of four acute myopericarditis revealing Wegener's granulomatosis. Clinicians should consider the possibility of Wegener's granulomatosis in case of recurrent pericarditis and look for features suggestive of granulomatous disease affecting the upper and lower respiratory tract. In this setting, antineutrophil cytoplasmic autoantibodies (ANCA) testing and/or biopsy of involved organs appear of particular interest to confirm the diagnosis. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  8. Liver changes in Wegener's granulomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, H.; Struve, C.

    1981-05-01

    A 54-year-old woman is described, who had been treated with immunosuppressive therapy for Wegener's granuloma for several years. The clinical course was surprisingly long and benign. An incidental sonographic and scintigraphic finding was a change in the liver which healed at the same time as the lung lesions and which is therefore assumed to have been due to inflammatory involvement of the liver.

  9. Sinonasal Wegener's granulomatosis: CT characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Benoudiba, F.; Marsot-Dupuch, K.; Rabia, Hadj M.; Lasjaunias, P. [Neuroradiology Department, Bicetre Hospital, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre (France); Cabanne, J. [Department of Internal Medecine, Saint-Antoine Hospital, 184 rue du Faubourg Saint-Antoine, 75012 Paris (France); Bobin, S. [Head and Neck Department, Bicetre Hospital, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre (France)

    2003-02-01

    Wegener's granulomatosis (WG) is a severe and potentially lethal granulomatosis. Even though no specific radiological criteria exist, CT may suggest the correct diagnosis at an early stage. Recent improvement in the prognosis is related to earlier diagnosis, allowing the initiation of efficient and specific treatment before any severe complications occur. We reviewed a series of WG cases in order to establish the CT diagnostic criteria. (orig.)

  10. Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients

    International Nuclear Information System (INIS)

    Lee, Kyung Soo; Kim, Tae Sung; Kim, Eun A.; Fujimoto, Kiminori; Moriya, Hiroshi; Watanabe, Hideyuki; Tateishi, Ukihide; Ashizawa, Kazuoto; Johkoh, Takeshi; Kwon, O. Jung

    2003-01-01

    Our objective was to describe the CT findings of thoracic Wegener's granulomatosis. At presentation, both conventional and thin-section CT scans were available in 30 patients with Wegener's granulomatosis. Serial CT scans (range of intervals: 1-25 months, mean 4.5 months) were available in 20 patients. The initial and follow-up CT scans were analyzed retrospectively by two observers in terms of pattern and extent of parenchymal and airway lesions. Positive CT findings were seen in 29 of 30 (97%) patients at initial presentation. The most common pattern was nodules or masses seen in 27 of 30 (90%) patients. They were multiple in 23 of 27 (85%) patients, bilateral in 18 (67%), subpleural in 24 (89%), and peribronchovascular in 11 (41%) in distribution. Bronchial wall thickening in the segmental or subsegmental bronchi was seen in 22 (73%) patients. Large airways were also abnormal in 9 (30%) patients. Patchy areas of consolidation and ground-glass opacity were seen in 7 (23%) patients, respectively. In 17 of 20 (85%) patients in whom follow-up CT scans were available, the parenchymal or airway lesion showed complete or partial improvement with treatment. The CT findings of Wegener's granulomatosis, although multiple and variable, consist mainly of bilateral subpleural or peribronchovascular nodules or masses and bronchial wall thickening in the segmental or subsegmental bronchi. Parenchymal and airway lesions improve with treatment in most patients. (orig.)

  11. Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study.

    Science.gov (United States)

    Merkel, Peter A; Lo, Grace H; Holbrook, Janet T; Tibbs, Andrea K; Allen, Nancy B; Davis, John C; Hoffman, Gary S; McCune, W Joseph; St Clair, E William; Specks, Ulrich; Spiera, Robert; Petri, Michelle; Stone, John H

    2005-04-19

    Venous thrombotic events (VTEs) have been observed in Wegener granulomatosis, but the incidence rate is not known. To measure the incidence of VTEs in patients with Wegener granulomatosis. Prospective, observational cohort study. A multicenter, randomized, double-blind, placebo-controlled treatment trial for Wegener granulomatosis. 180 patients with Wegener granulomatosis enrolled during periods of active disease. Venous thrombotic events (deep venous thromboses or pulmonary emboli) were documented and confirmed prospectively. Incidence rates were calculated on the basis of time to first VTE. Thirteen patients had VTEs before enrollment. During 228 person-years of prospective follow-up, 16 VTEs occurred in 167 patients with no history of VTE. Median time from enrollment to VTE for patients with an event was 2.1 months. The incidence of VTE among patients with Wegener granulomatosis was 7.0 per 100 person-years (95% CI, 4.0 to 11.4). Although prospectively recorded, screening for VTEs did not occur. The incidence rate of VTEs in Wegener granulomatosis is high when compared with available rates in the general population, patients with lupus, and patients with rheumatoid arthritis. These results have important implications for clinical care of patients with Wegener granulomatosis.

  12. The significance of Alfred Adler for the concept of narcissism.

    Science.gov (United States)

    Ansbacher, H L

    1985-02-01

    Alfred Adler's significance for the concept of narcissism is presented with reference to four aspects: 1) Adler's theory of masculine protest was evidently a factor influencing Freud to turn toward the phenomenon of narcissism. 2) Present-day understanding of narcissism shows remarkable similarity to Adler's views on psychodynamics and neurotic egocentricity. 3) Some contemporary criticisms of Freud's theory of narcissism are very similar to Adler's criticism. 4) Adler's theory of social interest permits subsumption of narcissism under lack of social interest rather than acceptance of it as an expression of innate socially negative tendencies.

  13. Alfred Schmidt y el potencial subversivo de la sensualidad

    OpenAIRE

    Lissette Silva Lazcano

    2013-01-01

    El filósofo alemán Alfred Schmidt analiza la relación entre naturaleza y hombre a partir del concepto de naturaleza de Marx. Schmidt explicita el “intercambio orgánico entre el hombre y la naturaleza”, resaltando que aunque la naturaleza se nos presenta siempre en el horizonte de formas históricamente cambiantes de su apropiación social, nosotros formamos parte de ella, sin embargo esta relación es siempre dialéctica. Pero este pensador va más allá y confronta la perspectiva marxiana de la re...

  14. Alfred Russell Wallace and the evolution of the human mind.

    Science.gov (United States)

    Gross, Charles

    2010-10-01

    Today the fame of Alfred Russell Wallace is as the independent codiscoverer with Charles Darwin of the origin of species by natural selection. Although they were on very amiable terms all their lives, 11 years after announcing their discovery, Wallace and Darwin had a major disagreement on the evolution of human cognition. The author considers how this divergence and other disagreements, particularly on the role of instinct, are related to the differences in their class backgrounds, education, experience with non-European cultures, and views on socialism, phrenology, mesmerism, and spiritualism.

  15. Assessment of the implementation risks for ALFRED demonstrator

    International Nuclear Information System (INIS)

    Constantin, M.; Diaconu, D.

    2016-01-01

    The risks related to the implementation of ALFRED demonstrator in Romania are discussed. The assessment is based on the risk matrix approach. Two groups of experts were used in the investigation: participants in FP7 ARCADIA projects and members of the FALCON consortium. The results consist of the hierarchy of the risks obtained based on the appreciations of the two groups. They are comparatively presented and discussed in terms of the identified critical risks and possible measures for prevention and mitigation. Additionally, some elements derived from the experience of similar project such as SUSEN and ELI-NP are discussed. (authors)

  16. Alfred Russel Wallace and the antivaccination movement in Victorian England.

    Science.gov (United States)

    Weber, Thomas P

    2010-04-01

    Alfred Russel Wallace, eminent naturalist and codiscoverer of the principle of natural selection, was a major participant in the antivaccination campaigns in late 19th-century England. Wallace combined social reformism and quantitative arguments to undermine the claims of provaccinationists and had a major impact on the debate. A brief account of Wallace's background, his role in the campaign, and a summary of his quantitative arguments leads to the conclusion that it is unwarranted to portray Victorian antivaccination campaigners in general as irrational and antiscience. Public health policy can benefit from history, but the proper context of the evidence used should always be kept in mind.

  17. Alfred Adler y la psicología académica / Alfred Adler and the academic psychology

    OpenAIRE

    Lück, Helmut E.; Universidad de Distancia-Hagen (Alemania)

    2016-01-01

    El presente trabajo tiene como tema las conflictivas relaciones entre Alfred Adler y la psicología académica de su época. La actitud ambivalente del fundador de la psicología individual fue causada, muy probablemente, por su fracaso para conseguir el permiso oficial para dictar clases en la Universidad de Viena, y se fortaleció por las actitudes decididamente antiacadémicas de algunos de sus seguidores. En el marco del presente estudio se contrasta esto con los planteamientos de dos important...

  18. The Alfred Nobel rocket camera. An early aerial photography attempt

    Science.gov (United States)

    Ingemar Skoog, A.

    2010-02-01

    Alfred Nobel (1833-1896), mainly known for his invention of dynamite and the creation of the Nobel Prices, was an engineer and inventor active in many fields of science and engineering, e.g. chemistry, medicine, mechanics, metallurgy, optics, armoury and rocketry. Amongst his inventions in rocketry was the smokeless solid propellant ballistite (i.e. cordite) patented for the first time in 1887. As a very wealthy person he actively supported many Swedish inventors in their work. One of them was W.T. Unge, who was devoted to the development of rockets and their applications. Nobel and Unge had several rocket patents together and also jointly worked on various rocket applications. In mid-1896 Nobel applied for patents in England and France for "An Improved Mode of Obtaining Photographic Maps and Earth or Ground Measurements" using a photographic camera carried by a "…balloon, rocket or missile…". During the remaining of 1896 the mechanical design of the camera mechanism was pursued and cameras manufactured. In April 1897 (after the death of Alfred Nobel) the first aerial photos were taken by these cameras. These photos might be the first documented aerial photos taken by a rocket borne camera. Cameras and photos from 1897 have been preserved. Nobel did not only develop the rocket borne camera but also proposed methods on how to use the photographs taken for ground measurements and preparing maps.

  19. Estudo "LOTHAR": avaliação de eficácia e tolerabilidade da combinação fixa de anlodipino e losartana no tratamento da hipertensão arterial primária The "LOTHAR" study: evaluation of efficacy and tolerability of the fixed combination of amlodipine and losartan in the treatment of essential hypertension

    Directory of Open Access Journals (Sweden)

    Osvaldo Kohlmann Jr

    2006-01-01

    Full Text Available OBJETIVO: O estudo LOTHAR avaliou a eficácia, tolerabilidade e os efeitos metabólicos em médio e longo prazo (um ano da combinação fixa de anlodipino e losartana versus anlodipino e losartana isoladamente. MÉTODOS: Estudo multicêntrico brasileiro, randomizado, duplo-cego e comparativo realizado com 198 pacientes com hipertensão arterial primária em estágios 1 e 2. RESULTADOS: A combinação fixa apresenta alta eficácia anti-hipertensiva que se mantém em longo prazo com percentual reduzido de escape do controle pressórico, inferior a dos dois regimes monoterápicos de comparação. Em longo prazo, mais de 60% dos pacientes tratados com a combinação fixa permaneceram com níveis da PAD OBJECTIVE: The LOTHAR study evaluated medium and long term (one year efficacy, tolerability and metabolic effects of the fixed combination of amlodipine and losartan compared to amlodipine or losartan alone. METHODS: Brazilian multicenter, randomized, double-blind and comparative trial performed with 198 patients in stage 1 and 2 essential hypertension. RESULTS: The fixed combination has a high antihypertensive efficacy that is sustained in the long term with very low percentage of loss of blood pressure control. This percentage is incidentally lower than that of the two monotherapy comparative regimens. In the long term, more than 60% of the patients treated with the fixed combination remained with DBP < 85 mmHg, and the antihypertensive effect, when assessed by ABPM persisted for 24 hours with a trough-to-peak ratio of 76.7%. The frequency of adverse events was quite low in this group, and the long-term incidence of leg edema was approximately four-fold lower than that observed with amlodipine alone. The fixed combination did not change glucose and lipid metabolism in the medium or in the long term. CONCLUSION: Based on these results, we can say that the combination of amlodipine and losartan - the first fixed combination of a calcium channel

  20. Alfred Josef Thelen--on the occasion of his seventy-fifth birthday.

    Science.gov (United States)

    Dobrowolski, J A

    2006-03-01

    Alfred Thelen has made many very important contributions to the field of optical thin films. To honor him on the occasion of his 75th birthday, I prepared a bibliography of his many contributions for the ninth Topical Meeting on Optical Interference Coatings. Here an updated list of Alfred Thelen's books, chapters, papers, conference reports, and patents is presented.

  1. Malignancies in Wegener's granulomatosis: incidence and relation to cyclophosphamide therapy in a cohort of 293 patients

    DEFF Research Database (Denmark)

    Faurschou, M.; Sorensen, I.J.; Mellemkjaer, L.

    2008-01-01

    To describe the incidence of malignancies in a cohort of Danish patients with Wegener's granulomatosis (WG) and to investigate the cancer risk associated with cyclophosphamide (CYC) -therapy in WG.......To describe the incidence of malignancies in a cohort of Danish patients with Wegener's granulomatosis (WG) and to investigate the cancer risk associated with cyclophosphamide (CYC) -therapy in WG....

  2. Etanercept-induced Wegener granulomatosis in a patient with rheumatoid arthritis.

    Science.gov (United States)

    Broshtilova, Valentina; Iliev, Emil; Gantcheva, Mary

    2013-01-01

    A very rare case of etanercept-induced Wegener's granulomatosis in a patient with long-standing rheumatoid arthritis is reported. A thorough critical analysis on Wegener's granulomatosis pathogenetic mechanisms is done. The peculiarities of etanercept pharmacodynamic features are also presented together with some suggestions of possible induction pathways. © 2013 Wiley Periodicals, Inc.

  3. An unusual orbital localization of wegener granulomatosis detected by 18F-FDG PET/CT.

    Science.gov (United States)

    Bertagna, Francesco; Treglia, Giorgio; Rossini, Pierluigi; Giubbini, Raffaele

    2014-08-01

    We report a case of a 61-year-old male patient affected by Wegener granulomatosis and left exophthalmos who underwent F-FDG PET/CT during follow-up for rectal cancer. The study was negative for secondary lesions but revealed high uptake at the left orbital mass consistent with Wegener granulomatosis.

  4. An atypical case of Wegener's granulomatosis complicated by sepsis and coxitis

    International Nuclear Information System (INIS)

    Makowski, A.; Faflik, J.

    1993-01-01

    There is presented an atypical case Wegener's granulomatosis of maxillo-nasal region without bony destruction. The case is unusual because of sepsis and purulent coxitis. The patient responded well to treatment with vincristine and cyclophosphamide. ANCA (anti-neutrophil cytoplasmic antibodies) assays have very good sensitivity and specificity for Wegener's granulomatosis. (author)

  5. Governing Civil Service Pay in China, by Alfred M. Wu. Copenhagen: NIAS Press, 2014. xvi+236 pp

    DEFF Research Database (Denmark)

    Brødsgaard, Kjeld Erik

    2016-01-01

    Book review of: Governing Civil Service Pay in China by Alfred M. Wu. Copenhagen: NIAS Press, 2014.......Book review of: Governing Civil Service Pay in China by Alfred M. Wu. Copenhagen: NIAS Press, 2014....

  6. Granulomatose de Wegener e estenose subglótica: descrição de caso Wegener's granulomatosis and subglottic stenosis: case description

    Directory of Open Access Journals (Sweden)

    Fernanda Guidolin

    2004-06-01

    Full Text Available Descreve-se o caso de um paciente com Granulomatose de Wegener, em tratamento com esteróides e ciclofosfamida, que, apesar do tratamento, evoluiu com dispnéia progressiva e rouquidão. A investigação mostrou tratar-se de uma estenose subglótica, sendo a dispnéia prontamente aliviada com a traqueostomia. São discutidos diagnósticos diferenciais e modalidades de tratamentos de estenose subglótica em portadores de Wegener.We describe a patient with Wegener Granulomatosis being treated with steroids and cyclofosfamide that developed progressive dyspnea and hoarseness despite of treatment. Investigation showed a subglotic stenosis. The dyspnea was relieved by tracheotomy. We discuss the differential diagnosis as well as a number of treatment modalities in patients with Wegener granulomatosis and subglottic stenosis.

  7. Wegener granulomatosis (granulomatosis with polyangiitis): evolving concepts in treatment.

    Science.gov (United States)

    Lynch, Joseph P; Tazelaar, Henry

    2011-06-01

    Wegener granulomatosis (WG), the most common of the pulmonary granulomatous vasculitides, typically involves the upper respiratory tract, lower respiratory tract (bronchi and lung), and kidney, with varying degrees of disseminated vasculitis. THE TERM GRANULOMATOSIS WITH POLYANGIITIS (WEGENER) WAS RECENTLY PROPOSED TO REPLACE THE OLDER TERM, WG. THE TERM GRANULOMATOSIS WITH POLYANGIITIS CAN BE ABBREVIATED TO GPA, WITH THE IDEA THAT THE EPONYM WEGENER WOULD BE OMITTED OVER TIME. Cardinal histologic features include a necrotizing vasculitis involving small vessels, extensive "geographic" necrosis, and granulomatous inflammation. Clinical manifestations of WG are protean; virtually any organ can be involved. The spectrum and severity of the disease are heterogeneous, ranging from indolent disease involving only one site to fulminant, multiorgan vasculitis. The pathogenesis of WG has not been elucidated, but both cellular and humoral components are involved. Circulating antibodies against cytoplasmic components of neutrophils [anti-neutrophil cytoplasmic antibodies (c-ANCAs)] likely play a role in the pathogenesis, and often correlate with activity of the disease. Treatment strategies are evolving. Cyclophosphamide (CYC) plus corticosteroids (CSs) is the mainstay of therapy for generalized, multisystemic WG. Historically, the combination of CYC plus CS was used for a minimum of 12 months, but concern about late toxicities associated with CYC has led to novel treatment approaches. Currently, short-course (3 to 6 months) induction treatment with CYC plus CS, followed by maintenance therapy with less toxic agents (e.g., methotrexate, azathioprine) is recommended. Further, methotrexate combined with CS may be adequate for limited, non-life-threatening WG. Recent studies suggest that rituximab may be useful for induction therapy or CYC-refractory WG. The role of other immunomodulatory agents (including trimethoprim-sulfamethoxazole) is also explored. © Thieme Medical

  8. Alfred P. Dachnowski and the scientific study of peats

    Science.gov (United States)

    Landa, E.R.; Cohen, K.M.

    2011-01-01

    Botanist Alfred Paul Dachnowski (1875–1949) was a major contributor to efforts at mapping organic soils in the United States during the early 20th century. He began his career at The Ohio State University, and spent most of his professional life at the U.S. Department of Agriculture in Washington, DC. His work spanned a diversity of topics, including bog ecology and the ecosystem services provided by wetlands, the mapping and chemical characterization of peat, and the commercial applications of peat. We present a biography and overview of his work. Dachnowski is best known today for the peat sampler that bears his name. The details of its operation are described here, and its place in modern peat studies is discussed.

  9. ALFRED: An Allele Frequency Database for Microevolutionary Studies

    Directory of Open Access Journals (Sweden)

    Kenneth K Kidd

    2005-01-01

    Full Text Available Many kinds of microevolutionary studies require data on multiple polymorphisms in multiple populations. Increasingly, and especially for human populations, multiple research groups collect relevant data and those data are dispersed widely in the literature. ALFRED has been designed to hold data from many sources and make them available over the web. Data are assembled from multiple sources, curated, and entered into the database. Multiple links to other resources are also established by the curators. A variety of search options are available and additional geographic based interfaces are being developed. The database can serve the human anthropologic genetic community by identifying what loci are already typed on many populations thereby helping to focus efforts on a common set of markers. The database can also serve as a model for databases handling similar DNA polymorphism data for other species.

  10. Crawford Long, Alfred Blalock, Louis Wright, and Georgia's Surgical Heritage.

    Science.gov (United States)

    Nakayama, Don K

    2016-02-01

    Georgia and the Atlanta area are associated with three important figures in the history of surgery. Crawford Long (1815-1878) discovered the anesthetic effects of ether while in practice in Jefferson. Born in Culloden, Alfred Blalock (1899-1964) was a pioneer researcher in shock and resuscitation, and developed the Blalock-Taussig shunt for Tetralogy of Fallot. His technician, African-American Vivien Thomas (1910-1985), was a full partner in the landmark advances. Louis T. Wright (1891-1952) was born in LaGrange and grew up in the Jim Crow South. As the country's leading black surgeon, he led the integration of major hospitals and helped lay the groundwork for the landmark civil rights legislation of the 1960s that integrated American medicine. Their stories, with roots in small towns in Georgia, reveal the deep surgical traditions of the South.

  11. Alfred Tarski early work in Poland—geometry and teaching

    CERN Document Server

    McFarland, Joanna; Smith, James

    2014-01-01

    Alfred Tarski (1901–1983) was a renowned Polish/American mathematician, a giant of the twentieth century, who helped establish the foundations of geometry, set theory, model theory, algebraic logic, and universal algebra. Throughout his career, he taught mathematics and logic at universities and sometimes in secondary schools. Many of his writings before 1939 were in Polish and remained inaccessible to most mathematicians and historians until now. This self-contained book focuses on Tarski’s early contributions to geometry and mathematics education, including the famous Banach–Tarski paradoxical decomposition of a sphere as well as high-school mathematical topics and pedagogy. These themes are significant since Tarski’s later research on geometry and its foundations stemmed in part from his early employment as a high-school mathematics teacher and teacher-trainer. The book contains careful translations and much newly uncovered social background of these works written during Tarski’s years in Poland....

  12. Wegener's granulomatosis. Report of five cases and revision of the literature

    International Nuclear Information System (INIS)

    Pedrozo Pupo, John C; Ortiz Ruiz, Guillermo; Ojeda Leon, Paulina; Carrillo Bayona, Jorge

    2001-01-01

    We describe the wegener's granulomatosis is illustrated by 5 case reports. Wegener's granulomatosis is a rare disease of unknown etiology, is characterized histologically by a necrotizing granulomatous vasculitis that most commonly involves the lungs together with the nasal pathways, paranasal sinuses, and kidneys, but may affect any organ system. There is increasing recognition of early forms of wegener's granulomatosis with limited disease extension an low activity. Treatment with cyclophosphamide and corticosteroids suppresses disease activity and results in long-term. Remissions. C-antineutrophil cytoplasmic antibodies and acute-phase reactants are helpful in monitoring overall activity, but they do not reflect the manifestation of disease in specific organ systems

  13. Pulmonary manifestations of wegener granulomatosis: CT findings in 57 patients and a review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Lohrmann, Christian; Uhl, Markus; Kotter, Elmar; Burger, Dieter; Ghanem, Nadir; Langer, Mathias

    2005-03-01

    Wegener granulomatosis is a multisystem disease of unknown cause characterized by a necrotizing granulomatous vasculitis. In comparison to other vasculitides, the lung is the most common organ involved in wegener granulomatosis presenting with a very aggressive airways pathology and chronic relapsing course. Chest radiographs fail to describe the pattern and distribution of thoracic pathology sufficiently, and CT has shown to be more sensitive for detecting lung involvement. We present the CT findings of 57 patients with wegener granulomatosis and a review of the literature.

  14. Kuidas Alfred Adler läks tülli Sigmund Freudiga / Aivar Kull

    Index Scriptorium Estoniae

    Kull, Aivar, 1955-

    1996-01-01

    Arvustus: Adler, Alfred. Inimesetundmine : Inimeste iseloomude peategurid ja nende areng / Tlk. Debora Hint. 2.tr. Tln. : Kupar, 1995. Vaata ka: Kull, Aivar. Kulli pilk. - Tartu : Ilmamaa, 2005, lk. 97-100

  15. [Alfred Ritscher. Reval an der schwelle zur neuzeit. T. 2] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2006-01-01

    Arvustus: Ritscher, Alfred. Reval an der schwelle zur neuzeit. T. 2: Vom tode Wolters von Plettenberg bis zum Untergang des Deutschen Ordens in Livland (1535-1561). Bonn: Kulturstiftung der deutshen Vertriebenen 2001. (Historische Forschungen).

  16. ASSOCIATION OF CHRONIC NASAL CARRIAGE OF STAPHYLOCOCCUS-AUREUS AND HIGHER RELAPSE RATES IN WEGENER GRANULOMATOSIS

    NARCIS (Netherlands)

    Stegeman, Coen; Tervaert, J.W.C.; Sluiter, W.J.; Manson, W.L.; DEJONG, P.E.; Kallenberg, Cees

    1994-01-01

    Objective: To examine possible risk factors for relapse, including chronic nasal carriage of Staphylococcus aureus and serial antineutrophil cytoplasmic antibody (ANCA) determinations in patients with Wegener granulomatosis. Design: Observational cohort study. Setting: Outpatient clinic at a

  17. [Wegener's granulomatosis with anti-neutrophil cytoplasmic antibodies against anti-cathepsin G antigen].

    Science.gov (United States)

    Ocaña Pérez, E; Peña Casas, A M; del Campo Muñoz, T; Avila Casas, A; Luque Barona, R

    2013-12-01

    Wegener's granulomatosis belongs to the group of small vessel vasculitis associated with anti-neutrophil cytoplasmic antibodies characterized by granulomatous inflammation and necrotising vasculitis in various organs with particular involvement of the upper and lower respiratory tracts and kidneys. Wegener's granulomatosis is a rare disorder in childhood and early diagnosis of this disease is critical to the long-term prognosis of the disease. The presence of positive cytoplasmic antineutrophil cytoplasmic antibody staining or a high titre of proteinase 3 antibodies were added as new criteria of vasculitis in childhood. This article presents a case of Wegener's granulomatosis, with the presence of anti-neutrophil cytoplasm antibodies with cytoplasmic pattern with absence of anti-proteinase 3 antibodies and presence of high levels of anti-cathepsin G antibodies, rarely described in Wegener's granulomatosis. Copyright © 2012 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  18. A disease activity score for ENT involvement in granulomatosis with polyangiitis (Wegener's)

    DEFF Research Database (Denmark)

    Del Pero, Marcos Martinez; Chaudhry, Afzal; Rasmussen, Niels

    2013-01-01

    Accurate assessment of disease activity in patients with otorhinolaryngological manifestations of granulomatosis with polyangiitis (Wegener's) (ENT/GPA) is necessary for treatment decisions and clinical trials. We have designed a disease activity score (ENT/GPA DAS) for this purpose....

  19. Impaired health-related quality of life in patients treated for Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Sigaard, Lene; Bjørner, Jakob Bue

    2010-01-01

    To investigate whether patients with Wegener's granulomatosis (WG) experience reduced health-related quality of life (HRQOL) after accomplishment of remission, and to study the influence of WG-associated organ damage on HRQOL.......To investigate whether patients with Wegener's granulomatosis (WG) experience reduced health-related quality of life (HRQOL) after accomplishment of remission, and to study the influence of WG-associated organ damage on HRQOL....

  20. Alfred Adler, pioneer in prevention of mental disorders.

    Science.gov (United States)

    Ansbacher, H L

    1990-09-01

    Alfred Adler (1870-1937) one of the four original members of what was to become the Vienna Psychoanalytic Society, was the first to accept a humanistic-educational model of man in contrast to Freud's medical model of man. This was in line with his deep involvement with prevention; in fact his original interest was in medical prevention. The present paper describes how his work touched on all the points of the contemporary field of psychological prevention. He developed a personality theory most suitable for application in prevention, education and brief psychotherapy. He identified various categories of children at risk. He advocated the right to abortion partly to prevent the birth of a child severely at risk by being unwanted. He considered the then existing dominance of the male sex to be damaging to both sexes. He engaged in practical prevention work by addressing general audiences and especially teachers and by the establishment of and participation in Educational Counseling Centers. He felt that the honest psychologist for reasons of prevention is bound to social advocacy, and that a true psychology of mental health merges into a corresponding world philosophy. These points are fully documented with quotations and references.

  1. The Victoria and Alfred Waterfront as playground for Capetonians

    Directory of Open Access Journals (Sweden)

    Sanette Ferreira

    2014-07-01

    Full Text Available The paper contributes to the exploration and understanding of the social geographies of public space in the Victoria & Alfred Waterfront (V&AW in Cape Town. The aim is to understand Capetonians’ (visitors and employees perceptions of the V&AW as public, leisure, shopping and working spaces. The appropriate literature on waterfront developments in providing public, working and leisure space is reviewed. Two questionnaire surveys (visitors and employees as well as eight unstructured interviews with important role players in the tourism industry of Cape Town were conducted. Findings revealed the most important reasons for Capetonians to visit or use certain spaces in the V&AW, the public open spaces they liked and how they perceived the V&AW as an inclusive space. The research also sought the respondents’ views on how the certain public spaces can be improved; what new activities and retail shops can be introduced; their opinions about the affordability of restaurants and parking; and how the V&AW can improve to cater for the needs of the Waterfront’s employees. Recommendations are made for making the V&AW more functional and accessible to Capetonians.

  2. Alfred Nobel and His Prizes: From Dynamite to DNA.

    Science.gov (United States)

    Lichtman, Marshall A

    2017-07-01

    Alfred Nobel was one of the most successful chemists, inventors, entrepreneurs, and businessmen of the late nineteenth century. In a decision later in life, he rewrote his will to leave virtually all his fortune to establish prizes for persons of any nationality who made the most compelling achievement for the benefit of mankind in the fields of chemistry, physics, physiology or medicine, literature, and peace among nations. The prizes were first awarded in 1901, five years after his death. In considering his choice of prizes, it may be pertinent that he used the principles of chemistry and physics in his inventions and he had a lifelong devotion to science, he suffered and died from severe coronary and cerebral atherosclerosis, and he was a bibliophile, an author, and mingled with the literati of Paris. His interest in harmony among nations may have derived from the effects of the applications of his inventions in warfare ("merchant of death") and his friendship with a leader in the movement to bring peace to nations of Europe. After some controversy, including Nobel's citizenship, the mechanisms to choose the laureates and make four of the awards were developed by a foundation established in Stockholm; the choice of the laureate for promoting harmony among nations was assigned to the Norwegian Storting, another controversy. The Nobel Prizes after 115 years remain the most prestigious of awards. This review describes the man, his foundation, and the prizes with a special commentary on the Nobel Prize in Physiology or Medicine.

  3. Alfred Binet and the concept of heterogeneous orders

    Directory of Open Access Journals (Sweden)

    Joel eMichell

    2012-08-01

    Full Text Available In a comment, hitherto unremarked upon, Alfred Binet, well known for constructing the first intelligence scale, claimed that his scale did not measure intelligence, but only enabled classification with respect to a hierarchy of intellectual qualities. Attempting to understand the reasoning behind this comment leads to an historical excursion, beginning with the ancient mathematician, Euclid and ending with the modern French philosopher, Henri Bergson. As Euclid explained (Heath, 1908, magnitudes constituting a given quantitative attribute are all of the same kind (i.e., homogeneous, but his criterion covered only extensive magnitudes. Duns Scotus (Cross, 1998 included intensive magnitudes by considering differences, which raised the possibility (later considered by Kant (Sutherland, 2004 of ordered attributes with heterogeneous differences between degrees (heterogeneous orders. Of necessity, such attributes are non-measurable. Subsequently, this became a basis for the quantity objection to psychological measurement, as developed first by Tannery (1875 and then by Bergson (1889. It follows that for attributes investigated in science, there are three structural possibilities: (1 classificatory attributes (with heterogeneous differences between categories; (2 heterogeneous orders (with heterogeneous differences between degrees; and (3 quantitative attributes (with thoroughly homogeneous differences between magnitudes. Measurement is possible only with attributes of kind (3 and, as far as we know, psychological attributes are exclusively of kinds (1 or (2. However, contrary to the known facts, psychometricians, for their own special reasons insist that test scores provide measurements.

  4. Alfred Binet and the Concept of Heterogeneous Orders†

    Science.gov (United States)

    Michell, Joel

    2012-01-01

    In a comment, hitherto unremarked upon, Alfred Binet, well known for constructing the first intelligence scale, claimed that his scale did not measure intelligence, but only enabled classification with respect to a hierarchy of intellectual qualities. Attempting to understand the reasoning behind this comment leads to an historical excursion, beginning with the ancient mathematician, Euclid and ending with the modern French philosopher, Henri Bergson. As Euclid explained (Heath, 1908), magnitudes constituting a given quantitative attribute are all of the same kind (i.e., homogeneous), but his criterion covered only extensive magnitudes. Duns Scotus (Cross, 1998) included intensive magnitudes by considering differences, which raised the possibility (later considered by Sutherland, 2004) of ordered attributes with heterogeneous differences between degrees (“heterogeneous orders”). Of necessity, such attributes are non-measurable. Subsequently, this became a basis for the “quantity objection” to psychological measurement, as developed first by Tannery (1875a,b) and then by Bergson (1889). It follows that for attributes investigated in science, there are three structural possibilities: (1) classificatory attributes (with heterogeneous differences between categories); (2) heterogeneous orders (with heterogeneous differences between degrees); and (3) quantitative attributes (with thoroughly homogeneous differences between magnitudes). Measurement is possible only with attributes of kind (3) and, as far as we know, psychological attributes are exclusively of kinds (1) or (2). However, contrary to the known facts, psychometricians, for their own special reasons insist that test scores provide measurements. PMID:22912619

  5. Alfred binet and the concept of heterogeneous orders.

    Science.gov (United States)

    Michell, Joel

    2012-01-01

    In a comment, hitherto unremarked upon, Alfred Binet, well known for constructing the first intelligence scale, claimed that his scale did not measure intelligence, but only enabled classification with respect to a hierarchy of intellectual qualities. Attempting to understand the reasoning behind this comment leads to an historical excursion, beginning with the ancient mathematician, Euclid and ending with the modern French philosopher, Henri Bergson. As Euclid explained (Heath, 1908), magnitudes constituting a given quantitative attribute are all of the same kind (i.e., homogeneous), but his criterion covered only extensive magnitudes. Duns Scotus (Cross, 1998) included intensive magnitudes by considering differences, which raised the possibility (later considered by Sutherland, 2004) of ordered attributes with heterogeneous differences between degrees ("heterogeneous orders"). Of necessity, such attributes are non-measurable. Subsequently, this became a basis for the "quantity objection" to psychological measurement, as developed first by Tannery (1875a,b) and then by Bergson (1889). It follows that for attributes investigated in science, there are three structural possibilities: (1) classificatory attributes (with heterogeneous differences between categories); (2) heterogeneous orders (with heterogeneous differences between degrees); and (3) quantitative attributes (with thoroughly homogeneous differences between magnitudes). Measurement is possible only with attributes of kind (3) and, as far as we know, psychological attributes are exclusively of kinds (1) or (2). However, contrary to the known facts, psychometricians, for their own special reasons insist that test scores provide measurements.

  6. Esclerite nodular e poliangiite granulomatosa (Wegener mimetizando tuberculose

    Directory of Open Access Journals (Sweden)

    Cybelle Moreno Luize Franco

    2015-04-01

    Full Text Available Poliangiite granulomatosa é uma doença sistêmica que afeta qualquer órgão, com predileção pelo trato respiratório superior, pulmões e rins. Este artigo tem como objetivo relatar um caso atípico de uma paciente com esclerite nodular como manifestação inicial da poliangiite granulomatosa (Wegener, mimetizando um quadro de tuberculose. A paciente apresentou hiperemia ocular e baixa acuidade visual progressiva por 1,5 anos, seguido por dor ocular por dois meses. A paciente possuía nódulos subpleurais com densidade de partes moles, linfonodomegalia em janela aorto-pulmonar e espessamento pleural bilateral discreto, negativo para bacilos álcool-ácido resistentes (BAAR. O diagnóstico histológico revelou uma vasculite granulomatosa sugestiva de vasculite não infecciosa (poliangiite granulomatosa. Foi iniciada pulsoterapia com ciclofosfamida.

  7. Wegener granulomatosis as an uncommon cause of panhypopituitarism in childhood.

    Science.gov (United States)

    Kara, Ozlem; Demirel, Fatma; Acar, Banu Celikel; Cakar, Nilgün

    2013-01-01

    Wegener granulomatosis (WG) is a cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)-associated, multi-system, necrotizing granulomatous vasculitis. Inflammation of the nasal or oral mucosa, and lung and kidney involvements are typical in the course of the disease. In rare cases, pituitary involvement may occur and cause panhypopituitarism. Pituitary involvement is very rare, and only two pediatric case reports have been published to date out of a total of 24 cases. This is a case report of an adolescent patient who presented with panhypopituitarism symptoms and was later diagnosed with WG. A 16-year-old female patient complained of fever, headache, purulent nasal discharge and severe muscle and joint pain. Additionally, she had polyuria and polydipsia. Investigations revealed a pituitary mass and panhypopituitarism. Positivity of c-ANCA and renal biopsy result compatible with WG confirmed the diagnosis.

  8. Wegener granulomatosis presenting as refractory otitis media: a case report.

    Science.gov (United States)

    Mercan, Gül Caner; Mercan, Bahattin; Cukurova, Ibrahim

    2012-01-01

    Wegener's granulomatosis (WG) is a granulomatous widespread necrotizing vasculitis, sometimes progressing rapidly, characterized by a tendency to involve the upper and lower respiratory tracts, and in most cases, the kidneys. Otologic manifestations may be seen during the course of the disease, however, they are not frequently seen as the first and only presenting feature. The presence of anticytoplasmic antibodies versus neutrophil polymorphonucleate granules (c-ANCA) is highly specific for the diagnosis of WG, being positive in 97% of the cases. The early diagnosis and the timely medical treatment result in high rates of remission of this potentially lethal disease. In this article, we report a case of WG presenting with acute serous otitis media, progressing to suppurative otitis media and granulomas as the first and only symptom, which was refractory to medical therapy during follow-up and which was diagnosed with further examination.

  9. Orbital granulomatosis with polyangiitis (Wegener granulomatosis): clinical and pathologic findings.

    Science.gov (United States)

    Muller, Karra; Lin, Jonathan H

    2014-08-01

    The pathology of granulomatosis with polyangiitis (GPA), formerly Wegener granulomatosis, typically features a granulomatous and sometimes necrotizing vasculitis targeting the respiratory tract and kidneys. However, orbital involvement occurs in up to 60% of patients and is frequently the first or only clinical presentation in patients with systemic or limited forms of GPA. Orbital GPA can cause significant morbidity and potentially lead to complete loss of vision and permanent facial deformity. Fortunately, GPA is highly responsive to medical treatment with corticosteroids combined with cyclophosphamide or, more recently, rituximab. Therefore, it is imperative for this disease to be accurately diagnosed on orbital biopsy and distinguished from other histologically similar orbital lesions. Herein, we review the clinical and pathologic findings of orbital GPA, focusing on the differentiation of this disease from other inflammatory orbital lesions.

  10. [Granulomatosis with polyangiitis (previously Wegener's granulomatosis) mimicking malingering].

    Science.gov (United States)

    Ene, N; Bélénotti, P; Benyamine, A; Sovaila, S; Ben Sahla Talet, M H; Kaminsky, P; Serratrice, J; Weiller, P-J

    2014-08-01

    ANCA vasculitis may involve the skin and develop slowly without specific histology, and without autoantibodies. We report a 50-year-old woman who experienced bilateral mastectomy because of ulcero-necrotic, non-specific inflammatory cutaneous lesions of the breasts. First considered by others as a malinger patient, she developed oto-neurological lesions leading to the diagnosis of Wegener's granulomatosis. Five years later, specific antibodies of the disease were present. Cutaneous involvement by ANCA vasculitis can be isolated for a long time. Physicians must have a high degree of suspicion to avoid diagnostic delay of ANCA vasculitis. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

  11. Treatment of orbital inflammation with rituximab in Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Baslund, Bo; Wiencke, Anne Katrine; Rasmussen, Niels

    2012-01-01

    OBJECTIVES: To study the efficacy of rituximab therapy for the treatment of orbital inflammation in patients with Wegener's granulomatosis (WG). METHODS: Ten WG patients with orbital inflammation were included in this case-series. None had symptoms suggestive of extra-orbital disease activity...... inflammation. All patients were treated with 1000 mg of rituximab administered twice with an interval of 14 days between the infusions. Six months after therapy, a physical examination and a control computerised tomography (CT) scan was performed. RESULTS: All patients had orbital inflammation demonstrated...... by CT-scan before treatment (3 had bilateral and 7 unilateral orbital involvement). Orbital symptoms at study baseline included pain, pressure sensation behind the eyes, epiphora, diplopia, and affection of the visual acuity. Nine out of ten patients experienced subjective improvement. Four patients...

  12. [Wegener granulomatosis and aneurysmal subarachnoid hemorrhage: an insignificant association?].

    Science.gov (United States)

    Marnet, D; Ginguené, C; Marcos, A; Cahen, R; Mac Gregor, B; Turjman, F; Vallée, B

    2010-08-01

    Wegener granulomatosis (WG) is an uncommon systemic necrotizing vasculitis that demonstrates renal and respiratory tropism. While the pathogenesis of WG remains controversial, autoimmune and inflammatory mechanisms are likely to be involved. The nervous system could be affected in up to 54% of cases. Although central nervous system involvement has been reported in 7-11% of cases, aneurysmal subarachnoid hemorrhage (SAH) occurrence is exceptional. We describe the third reported case of WG-related aneurysmal SAH and then discuss the diagnosis and pathogenesis of WG along with the physiopathology of intracranial aneurysm in light of recent data reported in the literature. A 63-year-old woman with WG was referred to our neurosurgical department for aneurysmal SAH. The vasculitis diagnosis had been established 4 years earlier when she presented with chronic sinusitis, recurrent cystitis, and renal failure. The cerebral angiography revealed an anterior communicating artery dysplastic aneurysm. The neurosurgical management of the aneurysm was scheduled but delayed because the patient was experiencing a vasculitis flare-up. Immunosuppressive therapy and intravenous corticotherapy were given, with the patient's improvement, allowing neurosurgical clipping of the aneurysm. Wegener granulomatosis-related aneurysmal SAH is an exceptional condition in neurovascular pathology. As inflammatory mechanisms are involved in the pathogenesis of aneurysm, the vasculitis flare-up could account for this SAH. The management of WG could benefit from anti-inflammatory therapy, as could the vasculitis-related SAH. SAH occurrence in patients with systemic vasculitis could indicate a vasculitis flare-up. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

  13. Granulomatose de Wegener: Envolvimento otológico, nasal, laringotraqueal e pulmonar Wegener granulomatosis: Otologic, nasal, tracheobronchial and pulmonary involvement

    Directory of Open Access Journals (Sweden)

    Sandra Figueiredo

    2009-10-01

    Full Text Available A granulomatose de Wegener é uma vasculite sistémica rara e idiopática caracterizada pelo atingimento dos pequenos vasos. A doença atinge, preferencialmente, as vias aérea superior e inferior e os rins, levando à formação de granulomas e necrose destes órgãos. As manifestações clínicas e o envolvimento orgânico variam largamente. O diagnóstico e tratamento precoce podem levar à recuperação total. No entanto, o atraso no diagnóstico pode ser fatal. Os autores apresentam o caso de uma doente de 33 anos com uma forma de apresentação grave e rara da doença, mas com uma evolução favorável após diagnóstico e tratamento adequado.Wegener granulomatosis is a rare systemic idiopathic disease characterized by involvement of small vessels - medium and small arteries, venules, arterioles and ocasionally large arteries. This disease has predilection for the upper and lower respiratory tract and the kidney, with granulomatous inflamation and necrosis. Clinical manifestations and organ involvement of the disease vary widely. Early diagnosis and treatment may lead to a full recovery. Without treatment, Wegener’s granulomatosis can be fatal. The authors present a case of a 33 year-old female, with severe disease, but with good outcome, after adequate diagnosis and treatment.

  14. Pseudotumor pulmonar como apresentação inicial de granulomatose de Wegener Lung pseudotumor as the initial presentation of Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    Marcelo Fouad Rabahi

    2009-04-01

    Full Text Available A granulomatose de Wegener é uma doença inflamatória multissistêmica de etiologia desconhecida, que se caracteriza por vasculite de pequeno e médio calibre. As manifestações clínicas mais comuns envolvem o trato respiratório superior, pulmões e rins e as alterações encontradas nos exames de imagem são geralmente opacidades pulmonares ou nódulos múltiplos, bilaterais e, em 50% dos casos, cavitações. O tratamento é feito com corticoides e imunossupressores. Descreve-se um caso atípico de um homem de 61 anos cuja investigação inicial de um tumor pulmonar unilateral evidenciou, na verdade, Granulomatose de Wegener.Wegener's granulomatosis is a multisystemic inflammatory illness of unknown etiology, characterized by vasculitis of small and medium caliber vessels. The most common clinical manifestations involve the upper respiratory tract, lungs and kidneys. Common alterations in imaging studies include pulmonary opacities and bilateral multiple nodules, cavitations occurring in 50% of the cases. Treatment includes corticosteroids and immunosuppressants. We describe an atypical case of a 61-year-old man initially investigated due to suspicion of a unilateral lung tumor, which proved to be, in fact, a case of Wegener's granulomatosis.

  15. Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease?

    Science.gov (United States)

    Witko-Sarsat, Véronique; Thieblemont, Nathalie

    2018-03-01

    Granulomatosis with polyangiitis (GPA, Wegener granulomatosis) is a systemic autoimmune vasculitis that affects small arteries, arterioles, and capillaries, most notably in the kidneys and lungs. In this disease, proteinase-3 (PR3), produced by neutrophils, is targeted by antineutrophil cytoplasmic antibodies (ANCA). Recent work by our group has shown how PR3 impairs the resolution of inflammation and deregulates the immune system. Normally, the clearance of activated neutrophils triggers an anti-inflammatory, pro-resolution process. In patients with GPA, however, macrophages phagocytose apoptotic neutrophils then release massive amounts of pro-inflammatory mediators, notably interleukin-1, thereby generating a pro-inflammatory microenvironment conducive to autoimmunity. This deregulation of immune processes is accompanied with activation of plasmacytoid dendritic cells and with polarization of T-helper-2 (Th2), Th9, and Th17 cells. These recent data highlight the dual role of PR3, both auto-antigenic and auto-inflammatory, thus potentially opening up new therapeutic avenues. Copyright © 2017 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.

  16. Imaging diagnosis of orbital Wegener granulomatosis: A rare case report.

    Science.gov (United States)

    Yang, Bin; Yin, Zhijian; Chen, Shuai; Yuan, Feng; Zhao, Wei; Yang, Yaying

    2017-06-01

    Wegener granulomatosis (WG) is a rare idiopathic autoimmune disease causing necrotizing granulomatous vasculitis. Whether as the first symptom or as part of systemic changes, ocular manifestations in WG patients are not specific. Any part of the eyes can be affected, with the anterior segment and orbit most commonly involved. So, early diagnosis and treatment are essential for controlling the progression of the disease and improving the quality of life for patients. Here we present a rare case of orbital WG of a 22-year-old woman was admitted to the hospital because of intense pain associated with decreased visual acuity in her right eye since 1 day. She had been previously diagnosed with WG at our hospital. Orbital computed tomography imaging showed diffuse swelling of intraorbital muscles, and space-occupying lesions were present in both eyes. Most postnasal anatomical structures were absent, appearing as a massive cavity shadow. Orbital magnetic resonance imaging showed a shadow of orbital soft tissues. WG is a serious, fatal disease. Early diagnosis and treatment are essential for controlling the progression of the disease and improving the quality of life for patients.

  17. Sellar Wegener Granulomatosis Masquerading as Cabergoline-Resistant Prolactinoma.

    Science.gov (United States)

    Eli, Ilyas M; Raheja, Amol; Corn, Heather J; Simmons, Debra L; Palmer, Cheryl Ann; Couldwell, William T

    2016-11-01

    Pituitary manifestation of Wegener granulomatosis (WG) is extremely rare. When there is pituitary involvement, the granulomatous inflammatory lesions involving the pituitary gland may appear several months to years after the primary diagnosis. We present a case of a 32-year-old woman who presented with galactorrhea, amenorrhea, and elevated serum prolactin levels. Imaging demonstrated a sellar lesion with characteristics of a pituitary macroadenoma. Treatment with cabergoline was initiated, but the tumor continued to grow during a 6-month period. Subsequent surgical exploration revealed a chronic inflammatory lesion; the patient subsequently was diagnosed with WG based on laboratory evaluation and further systemic manifestations. She had a favorable clinical and radiologic response with immunosuppressive doses of glucocorticoids and rituximab. This case appears to be the first reported of a patient with unknown WG in whom the diagnosis was established after she presented with a sellar lesion mimicking a prolactin-secreting pituitary adenoma on initial presentation requiring surgical resection. The only endocrine abnormality discovered was moderate hyperprolactinemia. Sellar lesions with only moderate elevations in serum prolactin, particularly those that are refractory to medical management with a dopamine agonist, should prompt further investigation to confirm the diagnosis. WG should be part of the differential diagnosis of inflammatory lesions in the sella, the identification of which can facilitate early diagnosis and treatment of this systemic disease for optimal outcome. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Chest CT findings in pediatric Wegener's granulomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Levine, Daniel [British Columbia Children' s Hospital, Department of Radiology and Nuclear Medicine, Vancouver, British Columbia (Canada); Akikusa, Jonathan [Royal Children' s Hospital Melbourne, Department of Rheumatology, Melbourne (Australia); Manson, David [Hospital for Sick Children, Department of Radiology, Toronto (Canada); Silverman, Earl; Schneider, Rayfel [Hospital for Sick Children, Department of Rheumatology, Toronto (Canada)

    2007-01-15

    Although pulmonary involvement occurs in the majority of children and adolescents with Wegener's granulomatosis (WG), relatively little has been published regarding the CT imaging manifestations in this group of patients. To determine the frequency and types of chest CT abnormalities in active pediatric WG (pWG). The study was a retrospective examination of 29 chest CT examinations performed at diagnosis (n=14) and during disease flares (n=15) in 18 children. The most common abnormalities were nodules (seen in 90% of examinations), ground-glass opacification (52%), and air-space opacification (45%). Of examinations with nodules, 73% demonstrated nodules >5 mm in diameter and 69% demonstrated more than five nodules; 17% had cavitary lesions. The only abnormality with a significant difference in prevalence between diagnosis and disease flares was air-space opacification, present in 71% and 20%, respectively (P < 0.01). In accordance with the findings of published adult studies and at variance with those of prior pediatric studies, our findings indicate that chest CT abnormalities in active pWG are frequent, most commonly comprising nodules and ground-glass opacification, which may be difficult to detect on plain radiography. We therefore advocate the routine use of chest CT for all affected patients, both at the time of presentation and during disease flares. (orig.)

  19. Hemorrhagic colitis as a presenting feature of Wegener granulomatosis.

    Science.gov (United States)

    Qian, Qi; Cornell, Lynn; Chandan, Vishal; Hartman, Robert; Caples, Sean

    2010-12-01

    Wegener granulomatosis (WG) is an idiopathic small vessel vasculitis involving primarily airway and kidneys. Intestinal involvement of WG is rare and usually occurs after several years of WG and its treatment. We report a case of WG, presented initially as rapid-onset hemorrhagic pancolitis without any preexisting or concurrent illness or any medication use. A 79-year-old previously healthy woman presented with 2-day duration of bloody diarrhea. Colonoscopy showed pancolitis with numerous ulcers; the biopsy showed foci of inflammation, ulceration and hemorrhage in the lamina propria, without features of chronic inflammatory bowel disease. Her stool studies were negative for infection. She subsequently developed pulmonary hemorrhage and kidney dysfunction. Kidney biopsy showed pauci-immune necrotizing glomerulonephritis. She responded to a combination therapy of steroids, cyclophosphamide and plasmapheresis with resolution of intestinal and pulmonary symptoms and improvement of kidney function. This case represents the first known example of colitis as an initial presentation of WG without confounding etiologic factors. Hemorrhagic colitis, although uncommon, may be the major presenting feature of WG.

  20. Rituximab for peripheral ulcerative keratitis with wegener granulomatosis.

    Science.gov (United States)

    Huerva, Valentín; Sanchez, María Carmen; Traveset, Alicia; Jurjo, Carmen; Ruiz, Agustín

    2010-06-01

    To demonstrate the effectiveness of Rituximab in the management of peripheral ulcerative keratitis (PUK) associated with Wegener granulomatosis (WG). A 50-year-old female with WG, confirmed by skin biopsy and positive anti-neutrophil cytoplasmic antibodies 3 years prior, was presented with a corneoscleral granulomatous mass that affected the superior limbus and with vasculitic PUK in the right eye. The mass was treated daily with oral prednisone (1 mg.kg-1.d-1) in conjunction with weekly maintenance treatment of 10 mg of methotrexate. After 2 months of treatment, the volume of the nodular granulomatous lesion decreased. However, the PUK and corneal thinning persisted, which presented a risk for corneal perforation. Subsequently, two 1000-mg infusions of rituximab were administered at weekly intervals. One week after the first administration of rituximab, we observed persistence of corneal thinning, flattening of the nodular lesion, and disappearance of the necrotic foci. After the second rituximab treatment, the patient exhibited no signs of corneal perforation and we further observed total epithelialization of the PUK. No systemic side effects were seen. After 2 months, no nodular lesion was observed, although conjunctival epithelialization from the previous PUK remained. Weekly methotrexate and 10 mg of prednisone per day were maintained. Rituximab seems to offer therapeutic promise in the treatment of refractory PUK associated with WG. Rituximab may be the elective treatment for severe anterior ocular inflammation associated with risk for corneal perforation, as a result of WG.

  1. Otologic symptoms as initial manifestation of wegener granulomatosis: diagnostic dilemma.

    Science.gov (United States)

    Wierzbicka, Małgorzata; Szyfter, Witold; Puszczewicz, Mariusz; Borucki, Lukasz; Bartochowska, Anna

    2011-08-01

    To show 7 cases of Wegener granulomatosis (WG) with early aural symptoms and to discuss the problems of otologic manifestation in WG. Retrospective case review. : Tertiary care university hospital. All patients were administered to the ENT University Department in Poznań in years 2002-2008 because of otitis media with effusion, facial palsy, sensorineural profound hypoacusis, hypoacusis combined with purulent discharge, and facial nerve palsy or progression of mixed type hypoacusis. Diagnostics and treatment. MAIN OUTCOME MEASURESL: Otologic symptoms as initial manifestation of WG diagnostic dilemma. The authors want to underline the young age of the patients, ranging from 32 to 46 years. The outcome of initially otologic cases, which developed generalized form of WG, was poor (the first patient died after 2 months, the second patient died after 7 days, the third had the pulmonary insufficiency in 2 months of observation, and the fourth had severe renal failure in 1 month), whereas the patients with localized disease have been successfully under control for 1 to 5 years. As WG often presents otologic symptoms, as an initial sign in some cases, it is important to take WG into consideration in atypical inflammatory states of the ear. The otologic onset of WG is very insidious, and prompt diagnosis in early stage of disease is a challenge. Focal and localized disease in the aural region might possibly require less aggressive therapy than acute-onset multi-organ disease and is connected with better prognosis.

  2. Severe impaired respiratory ciliary function in Wegener granulomatosis.

    Science.gov (United States)

    Ullrich, S; Gustke, H; Lamprecht, P; Gross, W L; Schumacher, U; Ambrosch, P; Laudien, M

    2009-06-01

    The pathogenesis of granulomatous inflammation in the respiratory tract and autoimmunity in Wegener granulomatosis (WG) are poorly understood. Since mucociliar clearance represents the first major line of defence in the respiratory tract and its breakdown facilitates chronic inflammation, we investigated ciliary beat frequency (CBF) in WG. Nasal epithelial cells were obtained from 30 patients with WG with involvement of the upper respiratory tract, 12 patients with other inflammatory rheumatic disease and 10 healthy controls. CBF was measured at 5 and 24 h after collection. were correlated with clinical data. Results: CBF was significantly reduced in WG compared to disease and healthy controls after 5 and 24 h. In WG, CBF almost stagnated after 24 h. Reduction of CBF correlated with the cumulative number of immunosuppressive agents in WG, but not in disease controls. No correlation was found between CBF impairment and cyclophosphamide levels, disease extent, disease activity, disease duration, serological and microbiological findings, or inflammation markers. CBF is severely impaired in WG, potentially influenced by immunosuppressive treatment. To what extent CBF impairment and subsequent barrier dysfunction are caused by other factors still has to be elucidated. Supportive measures to improve mucociliary clearance should be discussed in patients with WG.

  3. Cardiac involvement in Wegener granulomatosis diagnosed at autopsy.

    Science.gov (United States)

    Mukhopadhyay, Sanjay; Hensley, Richard G; Tazelaar, Henry D

    2010-01-01

    Wegener granulomatosis (WG) is a systemic vasculitis classically involving the lungs, kidneys, and upper respiratory tract. Involvement of other sites does occur but is less frequent. Clinically evident cardiac involvement is uncommon. There are only a few cases in the literature with documentation of the histologic appearance of cardiac involvement in WG. We report a case of a previously healthy 37-year-old man who presented with a one-week history of cough and weakness and a one-day history of shortness of breath. At presentation, he was hypoxic and required intubation. Upon hospitalization, he deteriorated rapidly, became bradycardic and expired the same night. Infection was suspected clinically as the cause of illness and death. At autopsy, the lungs showed diffuse alveolar hemorrhage with capillaritis, diffuse alveolar damage, and parenchymal necrosis with necrotizing granulomas. The heart was enlarged and showed a mixed inflammatory infiltrate composed of neutrophils, eosinophils, and histiocytes, with focal myocyte necrosis. Granulomas, giant cells, and vasculitis were absent. The esophagus showed submucosal vasculitis. A diagnosis of WG was made. Postmortem serology for c-ANCA was positive, and all cultures were negative, confirming the diagnosis. Cardiac involvement is an underrecognized and potentially fatal complication of WG. The histologic findings in the heart may consist of a non-specific inflammatory infiltrate without granulomas or vasculitis, raising a wide differential diagnosis. Copyright 2010 Elsevier Inc. All rights reserved.

  4. External dacryocystorhinostomy surgery in patients with Wegener granulomatosis.

    Science.gov (United States)

    Lee, Brian J; Nelson, Christine C; Lewis, Craig D; Perry, Julian D

    2012-01-01

    To determine surgical outcomes after external dacryocystorhinostomy (DCR) surgery in patients with Wegener granulomatosis (WG). The authors retrospectively reviewed the charts of consecutive patients with WG who underwent primary or secondary external DCR surgery between January 2001 and January 2010. Clinical data reviewed included patient demographics, systemic disease involvement and immunosuppression therapy, intraoperative biopsy findings, and postoperative outcomes and complications. Success was defined as resolution of epiphora. Sixteen primary external DCRs were performed on 9 patients with WG, and 2 secondary external DCRs were performed on 2 patients. At the time of surgery, all patients with WG were on systemic immunosuppressive agents including methotrexate, rapamycin, sirolimus, tacrolimus, azathioprine, cyclophosphamide, rituximab, and prednisone, and no patients received increased corticosteroids after surgery. Intraoperative biopsy in patients with WG revealed chronic inflammation (4 patients) and fibrosis (1 patient). Silicone stents were removed at an average of 5.8 months (range, 3-12 months). All surgeries were successful in resolving epiphora with an average follow up of 3.5 years (range, 10 months-6 years) and no complications. Primary and secondary external DCR surgery successfully treats nasolacrimal duct obstruction in patients with WG on systemic immunosuppression.

  5. Dorsal prevertebral lesions in Wegener granulomatosis: report on four cases.

    Science.gov (United States)

    Barreto, Paulo; Pagnoux, Christian; Luca, Luminata; Aouizerate, Jessie; Ortigueira, Isabel; Cohen, Pascal; Muller, Géraldine; Guillevin, Loïc

    2011-01-01

    Retroperitoneal fibrosis has been reported in several patients with Wegener granulomatosis (WG), but only three isolated cases of dorsal prevertebral lesions, closely resembling fibrosing mediastinitis, have been published so far. We describe four new WG patients (two men, two women), 49-59 years old at diagnosis, with dorsal prevertebral lesions, mainly right-sided, and with adjacent pleural thickening in two. These lesions were detected on computed-tomography scans at diagnosis in two patients, and occurred later in the two others. Only one of them had mild back pain. Two patients' lesions were biopsied, revealing granulomatous inflammation. In one patient, the lesion regressed under WG treatment. Lesion size did not change in the remainings. Intralesional calcifications appeared in two. None of the patients had local bone erosion, vascular or neurological complications. These prevertebral lesions might represent a dorsal form of retroperitoneal fibrosis in WG, but usually with a more benign presentation and course. WG should be included in the differential diagnosis of fibrosing mediastinitis (with tuberculosis, neoplastic diseases, sarcoidosis, histiocytosis and inflammatory pseudotumor), which may have a similar radiological appearance. Copyright © 2010 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.

  6. Massive Alveolar Hemorrhage During Wegener Granulomatosis: a Case Report

    Directory of Open Access Journals (Sweden)

    Gökhan Perincek

    2011-11-01

    Full Text Available This is a presentation of Wegener Granulomatosis (WG disease. Even though the lungs are rarely affected. massive alveolar hemorrhage is seen which leads to mortality. The patient was a 28 year old man. His illness was diagnosed as WG and glomerulonephritis a year previously and he was treated by administration of methylprednisolone orally. He had been treated irregularly. He applied to the emergency service with hemoptysis and asthma complaints two days earlier. After the results of his examination Hb: 3.6 gr/dl, Htc:10.3%, Üre:131 mg /dl, kreatini: 7.7 mg/dl, pH: 7.41, pO2: 55 mmHg, pCO2:33 mmHg, and being diagnosed as alveolar consolidation on lung X-ray, he was taken to the intensive care unit with a diagnosis of a massive alveolar hemorrhagei. He was intubated and attached to mechanical ventilation. He was treated with parenteral 1 mg/kg/day methylprednisolone and, siklofosfamid 2 mg/kg/day. He was extubated on the 21st day. He was taken to the chest service department on 24th day. He is still being treated.

  7. Variations sur Une promenade de Bélial d'Alfred Le Poittevin

    Directory of Open Access Journals (Sweden)

    Thomas Vercruysse

    2016-12-01

    Full Text Available À partir de remarques sur Une promenade de Bélial, conte philosophique d'Alfred Le Poittevin, cet article tente de proposer quelques éléments de réflexion pour éclairer la "mystique du style" de Flaubert à partir de la notion de métempsycose, au cœur du texte de Le Poittevin, ainsi qu’à travers le concept de « conatus » dû à Spinoza, référence discutée par Alfred et Gustave.

  8. Confessions of a serial entrepreneur: a conversation with Alfred E. Mann. Interview by Molly Joel Coye.

    Science.gov (United States)

    Mann, Alfred E

    2006-01-01

    In this wide-ranging interview, Alfred Mann describes the activities of several medical technology enterprises with which he is engaged. Several of them are companies that he formed; one is a nonprofit foundation, the Alfred E. Mann Foundation for Biomedical Engineering, founded to establish research-oriented institutes on a dozen university campuses and support their work in developing marketable innovations. Mann discusses the need to consider the cost implications of technology, in the context of U.S. health system reform, and describes several important innovations that have emerged from his companies over the years.

  9. Dvořákův Alfred. Překvapení po půldruhém století

    Czech Academy of Sciences Publication Activity Database

    Gabrielová, Jarmila; Dvořák, V.

    -, 27.8. (2014) Institutional support: RVO:68378076 Keywords : Antonín Dvořák * Alfred * concert performance Subject RIV: AL - Art, Architecture, Cultural Heritage http://operaplus.cz/dvorakuv-alfred-prekvapeni-po-puldruhem-stoleti/?pa=1

  10. [Subglottic stenosis as the initial manifestation of Wegener's granulomatosis in a teenager. Case report].

    Science.gov (United States)

    Cuestas, Giselle; Rodríguez, Verónica; Doormann, Flavia; Pringe, Alejandra; Bellia Munzón, Patricio; Bellia Munzón, Gastón; Ortega, Carlos; Álvarez, Rubén

    2017-04-01

    Wegener's granulomatosis is a necrotizing granulomatous vasculitis of autoimmune origin that primarily affects the upper and lower airways and kidneys. It is very rare in children and adolescents. When started at a young age it is often associated with subglottic stenosis. Subglottic stenosis is a potentially fatal manifestation of Wegener's granulomatosis. Its diagnosis requires a high index of suspicion since it might develop in the absence of other signs of activity. Occasionally, subglottic stenosis may present as the initial manifestation of the disease. Diagnosis is confirmed by endoscopic visualization of the lesion. The treatment is complex, and it often requires repeated interventions due to restenosis. We present a 13-year-old patient with subglottic stenosis secondary to Wegener's granulomatosis. We describe the clinical manifestations, diagnosis and treatment of this rare cause of respiratory distress in the pediatric population. Sociedad Argentina de Pediatría.

  11. Wegener granulomatosis as possible cause of vertigo: case report and review.

    Science.gov (United States)

    Goderis, J; De Schepper, S; Vannieuwenhuyze, P; Schmelzer, B

    2015-01-01

    Wegener granulomatosis (WG) or granulomatosis with polyangiitis (GPA) is a multi-system necrotizing granulomatous vasculitis that classically affects the upper respiratory tract, lungs and kidneys. We report the unusual clinical course of a patient with WG, and we present a literature review on the association between WG and vertigo. In our case, a 56-year-old female presented with a several-month history of chronic sinusitis and otalgia that was refractory to all initiated outpatient therapies. During hospitalization, a diagnostic evaluation revealed serious nasal crusting, chronic otitis media, and hematuria. Serologic testing showed elevated anti-neutrophil cytoplasmic antibodies (c-ANCAs). The tentative diagnosis of Wegener granulomatosis was confirmed by renal biopsy. Upon admission, the patient developed an acute vertigo with nystagmus, nausea, and vomiting, accompanied by sensorineural hearing loss in one ear. Vestibular symptoms may be associated with Wegener granulomatosis.

  12. Wegener's granulomatosis of the maxillary sinus: CT evaluation - report of two cases-

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong Hyun [Masan Korea General Hospital, Masan (Korea, Republic of)

    1991-03-15

    Wegener's granulomatosis is a specific vasculitis described by Klinger in 1931 and Wegener in 1939 as being different from periarteritis nodosa. Wegener's gramulomatosis involving the paranasal sinuses is relatively rare and few cases are reported in the Korean literature. However, CT evaluation has been lacking in the Korean literature. Although radiological evaluations were performed in the previous reports, they were not studied by CT. Only one report of the CT evaluation is available in the literature. Since the author observed somewhat different CT manifestations compared with the previous report, the CT findings with a brief review of the literature are presented. Although the difference from the previously reported series by Paling is not clear, it may be affected by differences in he duration of illness and severity of the disease.

  13. Tumor of the heart in a young woman; a rare manifestation of Wegener granulomatosis.

    Science.gov (United States)

    Singh, Remmi; Rosen, Seymour

    2012-02-01

    Wegener granulomatosis may rarely present with tumor masses that are in areas not typically involved by the disease. Although some cases have an associated positive anti-neutrophilic cytoplasmic antibodies, other cases do not, especially those of the limited form. To prevent misdiagnosis and ensure prompt treatment, it is extremely important to consider Wegener granulomatosis even in cases without the classic clinical findings. We report a case of a 19-year-old woman with no prior significant medical history who presented with persistent ventricular tachycardia and a papillary muscle mass in her left ventricle which upon excision and tissue evaluation demonstrated histologic changes of Wegener granulomatosis. Copyright © 2012 Elsevier Inc. All rights reserved.

  14. Strawberry gingivitis as the first presenting sign of wegener's granulomatosis: report of a case

    Science.gov (United States)

    2011-01-01

    Wegener's granulomatosis is a rare multi-system disease characterized by the classic triad of necrotizing granulomas affecting the upper and lower respiratory tracts, disseminated vasculitis and glomerulonephritis. Oral lesions as a presenting feature are only encountered in 2% of these cases. Hyperplastic gingival lesions or strawberry gingivitis, is a characteristic sign of Wegener's granulomatosis. The latter consists of reddish-purple exophytic gingival swellings with petechial haemorrhages thus resembling strawberries. Recognition of this feature is of utmost importance for timely diagnosis and definitive management of this potentially fatal disease. A case of strawberry gingivitis as the first presenting sign of Wegener's granulomatosis affecting a 50-year-old Malay male is reported here. The differential diagnosis of red lesions that may present in the gingiva is discussed. PMID:21813375

  15. Validation and correction of rainfall data from the WegenerNet high density network in southeast Austria

    Science.gov (United States)

    O, Sungmin; Foelsche, U.; Kirchengast, G.; Fuchsberger, J.

    2018-01-01

    Eight years of daily rainfall data from WegenerNet were analyzed by comparison with data from Austrian national weather stations. WegenerNet includes 153 ground level weather stations in an area of about 15 km × 20 km in the Feldbach region in southeast Austria. Rainfall has been measured by tipping bucket gauges at 150 stations of the network since the beginning of 2007. Since rain gauge measurements are considered close to true rainfall, there are increasing needs for WegenerNet data for the validation of rainfall data products such as remote sensing based estimates or model outputs. Serving these needs, this paper aims at providing a clearer interpretation on WegenerNet rainfall data for users in hydro-meteorological communities. Five clusters - a cluster consists of one national weather station and its four closest WegenerNet stations - allowed us close comparison of datasets between the stations. Linear regression analysis and error estimation with statistical indices were conducted to quantitatively evaluate the WegenerNet daily rainfall data. It was found that rainfall data between the stations show good linear relationships with an average correlation coefficient (r) of 0.97 , while WegenerNet sensors tend to underestimate rainfall according to the regression slope (0.87). For the five clusters investigated, the bias and relative bias were - 0.97 mm d-1 and - 11.5 % on average (except data from new sensors). The average of bias and relative bias, however, could be reduced by about 80 % through a simple linear regression-slope correction, with the assumption that the underestimation in WegenerNet data was caused by systematic errors. The results from the study have been employed to improve WegenerNet data for user applications so that a new version of the data (v5) is now available at the WegenerNet data portal (www.wegenernet.org).

  16. Obituary: James Alfred Van Allen, 1914-2006

    Science.gov (United States)

    Ludwig, George H.; McIlwain, Carl Edwin

    2006-12-01

    James Alfred Van Allen, world-renowned space scientist, died 9 August 2006 at the age of ninety-one. He succumbed to heart failure after a ten-week period of declining health. Van Allen served for his entire sixty-seven-year professional career as an amazingly productive researcher, space science spokesman, inspired teacher, and valued colleague. The realization by him and his associates that charged particles are trapped by the Earth's magnetic field began a whole new field of research, magnetospheric physics. Following that initial discovery, he and his associates quickly extended their observations, first to the inner planets, and then to the rest of the planets and beyond. During his tenure at Iowa, he and his group flew instruments on more than sixty successful Earth satellites and planetary spacecraft, including the first missions to the planets Venus, Mars, Jupiter, Saturn, Uranus, and Neptune. Van Allen's lifetime publication list numbers more than 275, of which many are widely-cited, seminal papers. He was the sole author of more than 125 of those papers. Beyond the research laboratory, Van Allen worked energetically throughout his career in establishing space research as a new branch of human inquiry. He was among the most sought-after as a committee member and adviser, working at the highest levels of government, including the White House and Congress, and at all levels of the national and international research establishments. Many presentations in the non-scientific arena helped to bring the exciting discoveries and challenges of space research to the attention of the general public. James Van Allen (Van to his many friends and colleagues) was born on 7 September 1914 on a small farm near Mount Pleasant, Iowa, the second of four sons of Alfred Morris Van Allen and Alma Olney Van Allen. After high school in Mount Pleasant, he entered Iowa Wesleyan College, majoring in physics and graduating summa cum laude. While there, he was introduced to geophysics

  17. [Coexistence of Crohn disease and Wegener granulomatosis in a 15-year-old patient].

    Science.gov (United States)

    Sieczkowska, Agnieszka; Lewandowski, Piotr; Szumera, Małgorzata; Kamińska, Barbara

    2011-01-01

    Crohn disease is being diagnosed more and more frequently in children and teenagers. Clinical symptoms are mainly related to the gastrointestinal tract, however there are many reports in the literature about the coexistence of Crohn disease with other autoimmunological disorders such as celiac disease, autoimmune hypothyroidism, systemic lupus erythematosus and Wegener granulomatosis. We report a 15-year-old patient with Crohn disease who also developed Wegener granulomatosis. The presented case illustrates the difficulties in establishing the diagnosis when symptoms of the original disease are superimposed on symptoms of a different disorder.

  18. Wegener's granulomatosis in North India. Radiologic manifestations in eleven patients

    Energy Technology Data Exchange (ETDEWEB)

    Bambery, P.; Katariya, S.; Sakhuja, V.; Kaur, U.; Behera, D.; Malik, S.K.; Deodhar, S.D.

    The chest radiograph in Wegener's granulomatosis reveals several striking, but not pathognomonic abnormalities. Nine (82%) of eleven patients with Wegener's granulomatosis had abnormal chest radiographs. Infiltrates were seen in all patients and were nodular in seven (77%). Six patients had cavities which were most often unilateral and thick walled. Serial radiographs showed the simultaneous appearance and resolution of infiltrates in 4 of 7 instances. Bilateral pulmonary involvement (67%), pleural effusion (33%), and pericardial effusion (22%) were also seen. Paranasal sinus involvement was seen in 4 of 5 studies. The chest radiograph was interpreted as tuberculosis in eight patients, resulting in delayed diagnosis and incorrect treatment.

  19. Why Community Works: The Use of Alfred Adler's Individual Psychology as a Foundational Theory.

    Science.gov (United States)

    Glenn, Robert K.; Keith, Edwin M.

    2002-01-01

    Asserts that the Individual Psychology of Alfred Adler should be used as a foundational theory for student affairs work. The success of community building programs is explained and the concepts of Individual Psychology are summarized. Also asserts that the current drive to develop programs to develop community on college campuses is firmly rooted…

  20. Periodic Reactions: The Early Works of William C. Bray and Alfred J. Lotka

    Science.gov (United States)

    Cervellati, Rinaldo; Greco, Emanuela

    2017-01-01

    Oscillating chemical reactions in the homogeneous phase have been studied intensively only since the mid-1960s, but they were known since 1920, having as forerunners the chemist William C. Bray and an "atypical" chemist Alfred J. Lotka. This contribution is the result of a careful reading of their literature and patient research into…

  1. A Paradoxical Partnership in Higher Education: The Alliance between Alfred C. Kinsey and Herman B Wells

    Science.gov (United States)

    Beineke, John A.

    2015-01-01

    Herman B Wells served as president of Indiana University from 1938 to 1962--from the days of the Great Depression into the turbulent 1960s. Alfred C. Kinsey was a professor, zoologist, and human sexuality researcher at Indiana University from 1920 until his death in 1956. A unique and paradoxical professional relationship existed between these two…

  2. Contrasting Views of Emotion in Learning: Alfred North Whitehead and Jerome Bruner

    Science.gov (United States)

    Woodhouse, Howard

    2017-01-01

    The article analyzes contrasting theories about the role of emotion in learning proposed by Alfred North Whitehead and Jerome Bruner. I argue that Whitehead's account of experience and emotion in his educational philosophy is best understood in the context of the philosophy of organism. Here he takes issue with the empiricists' view that sensa are…

  3. Cinemateca de Vertigo. El delirio de la mirada: Vertigo (1958, Alfred Hitchcock) Analisis de una secuencia

    OpenAIRE

    Castro de Paz, José Luis

    1992-01-01

    Castro De Paz, JL. (1992). Cinemateca de Vertigo. El delirio de la mirada: Vertigo (1958, Alfred Hitchcock) Analisis de una secuencia. Vértigo. Revista de cine. (2):43-48. http://hdl.handle.net/10251/42923. 43 48 2

  4. A fenomenologia social de Alfred Schutz e sua contribuicao para a enfermagem

    Directory of Open Access Journals (Sweden)

    Maria Cristina Pinto de Jesus

    2013-06-01

    Full Text Available O cuidado de enfermagem pode ser considerado uma ação social que tem como cenário o mundo cotidiano, onde são estabelecidas relações intersubjetivas que devem ser valorizadas pelo enfermeiro nos diversos contextos em que atua. Estudo teórico que teve como objetivo destacar as principais concepções da fenomenologia social de Alfred Schütz e sua contribuição para a Enfermagem como área de conhecimento e prática profissional. As seguintes questões nortearam este estudo: qual a compreensão do cuidar em Enfermagem sob a ótica da fenomenologia social de Alfred Schütz? Como aplicar as concepções teóricas de Alfred Schütz na ação de cuidar em Enfermagem? Foram demarcadas tais concepções e a interface destas com a Enfermagem. Ao incorporar à Enfermagem conceitos da teoria da ação social elaborados por Alfred Schütz, este estudo permite ao enfermeiro valorizar e aplicar os aspectos apontados por este referencial teórico no âmbito assistencial, no ensino e na investigação científica.

  5. Coexistent pulmonary granulomatosis with polyangiitis (Wegener granulomatosis) and Crohn disease.

    Science.gov (United States)

    Vaszar, Laszlo T; Orzechowski, Nicole M; Specks, Ulrich; Ytterberg, Steven R; Loftus, Edward V; Mark, Eugene J; Tazelaar, Henry D

    2014-03-01

    Crohn disease (CD) may be associated with various extraintestinal manifestations, including, rarely, respiratory tract involvement. When necrobiotic pulmonary nodules are present, the differential diagnosis includes granulomatosis with polyangiitis (Wegener granulomatosis) (GPA). The respiratory tract manifestations of CD and GPA may mimic each other, complicating the diagnosis and suggesting the possible coexistence of these 2 conditions. The aim of this study was to describe the clinical, radiographic, and pathologic features of patients in whom CD and GPA coexist. We reviewed the teaching files of the authors and searched the Mayo Clinic medical records for coexistent inflammatory bowel diseases and antineutrophilic cytoplasmic antibodies (ANCA)-associated vasculitides. We reviewed in detail 97 patient charts and excluded cases of ulcerative colitis and those in whom only one of the diagnoses was present. Pulmonary and gastrointestinal biopsies were reviewed when available. We also searched the medical literature for previously published cases. We found 6 cases of coexistent CD and pulmonary GPA and 4 cases with extrapulmonary GPA; 3 cases (all with extrapulmonary GPA) have been published previously. The diagnosis of CD preceded that of GPA in 11 cases. Proteinase 3-ANCA was positive in 6 cases, negative in 2, and not reported in 5 cases. Myeloperoxidase-ANCA was negative in 6 cases and unavailable in the remainder of patients. Pathology revealed features diagnostic of GPA in all cases with necrotizing granulomatous inflammation and segmental vasculitis. Pulmonary findings in patients with CD or the presence of granulomatous colitis in patients with GPA should prompt the inclusion in the differential diagnosis of a possible coexistence of CD and GPA.

  6. Cranial manifestation of Wegener's granuolomatosis: CT and MRI characteristics; Kraniale Manifestation des Morbus Wegener: Aktueller Stand der Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Hartmann, M.; Siebert, S.; Rohde, S. [Abt. Neuroradiologie, Neurologische Klinik, Universitaetsklinikum Heidelberg (Germany)

    2006-01-01

    Wegener's granulomatosis is a rare systemic granulomatous disease which primarily involves the upper and lower respiratory tract and the kidneys. In addition the orbits, the peripheral and the central nervous system may also be affected. Computed tomography and magnetic resonance imaging have been proven to be quite useful for the detection of these lesions, for assessment of the extent of involvement, and for documentation of response to therapy. The drawback of CT and MR studies is that they lack specifity. Characteristic imaging findings for WG is a medial wall destruction of the maxillary sinus with gross thickening of the anterior and infratemporal walls with relatively low soft tissue proliferation. On T2-weighted MR images the granulomatous tissue appears markedly hypointense with dense enhancement. Although these findings are not specific, if they are obvious, Wegener's granulomatosis should be considered in the differential diagnosis. (orig.)

  7. Comprometimento da árvore respiratória na granulomatose de Wegener Laryngeal and tracheobronchial involvement in Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    Ascedio Jose Rodrigues

    2012-04-01

    Full Text Available INTRODUÇÃO: A granulomatose de Wegener (GW é uma forma de vasculite sistêmica que envolve primariamente as vias aéreas superiores e inferiores e os rins. As manifestações mais frequentes nas vias aéreas são estenose subglótica e inflamações, estenoses da traqueia e dos brônquios. A visualização endoscópica das vias aéreas é a melhor ferramenta para avaliação, diagnóstico e manejo dessas alterações. OBJETIVOS: Descrever as alterações endoscópicas encontradas na mucosa das vias aéreas de um grupo de pacientes com GW submetido à broncoscopia no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP e relatar as intervenções terapêuticas broncoscópicas utilizadas em alguns casos. MÉTODOS: Foram estudados 15 pacientes com diagnóstico de GW provenientes do Ambulatório de Vasculites da Disciplina de Pneumologia do HC-FMUSP, encaminhados para a realização de broncoscopia no serviço de Endoscopia Respiratória do HC-FMUSP no período de 2003 a 2007. RESULTADOS: Dos 15 pacientes avaliados, 11 eram mulheres (73,33% com idade média de 34 ± 11,5 anos. Foram encontradas alterações das vias aéreas em 80% dos pacientes, e o achado endoscópico mais frequente foi estenose subglótica (n = 6. Realizou-se broncoscopia terapêutica em três pacientes com estenose subglótica e em outros três com estenose brônquica, todos apresentando bons resultados. CONCLUSÃO: A broncoscopia permite diagnóstico, acompanhamento e tratamento das lesões de vias aéreas na GW, constituindo-se um recurso terapêutico pouco invasivo em casos selecionados.INTRODUCTION: Wegener's granulomatosis (WG is a form of systemic vasculitis that involves primarily the upper and lower airways and the kidneys. The most frequent airway manifestations include subglottic stenosis and inflammation, and tracheal and bronchial stenoses. The endoscopic visualization of the airways is the best tool for assessing, diagnosing and

  8. Characteristics and Outcomes of Granulomatosis With Polyangiitis (Wegener) and Microscopic Polyangiitis Requiring Renal Replacement Therapy

    DEFF Research Database (Denmark)

    Hruskova, Zdenka; Stel, Vianda S; Jayne, David

    2015-01-01

    providing individual RRT patient data to the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry in 1993-2012 participated. PREDICTOR: Cause of primary kidney disease: AAV (ie, granulomatosis with polyangiitis [Wegener] and microscopic polyangiitis) versus 3 separate...

  9. Structured clinical assessment of the ear, nose and throat in patients with granulomatosis with polyangiitis (Wegener's)

    DEFF Research Database (Denmark)

    Martinez Del Pero, Marcos; Rasmussen, Niels; Chaudhry, Afzal

    2013-01-01

    The objective of this prospective cross-sectional study is to describe the clinical otorhinolaryngological manifestations of granulomatosis with polyangiitis (Wegener's) (GPA) in a prospective cohort. All patients suffering from GPA seen in a tertiary centre between March 2007 and November 2008 had...

  10. Increased morbidity from ischemic heart disease in patients with Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Mellemkjaer, Lene; Sorensen, Inge Juul

    2009-01-01

    OBJECTIVE: Experimental studies indicate that patients with Wegener's granulomatosis (WG) experience accelerated atherosclerosis. The purpose of this study was to investigate whether the occurrence of overt ischemic heart disease (IHD) is increased in WG. METHODS: A total of 293 WG patients were...

  11. Long-term damage to the ENT system in Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Martinez Del Pero, Marcos; Walsh, Michael; Luqmani, Raashid

    2011-01-01

    The objectives of the study are to describe long-term ENT damage and assess risk factors in patients with newly diagnosed and treated Wegener's granulomatosis (WG) using the vasculitis damage index (VDI). Data from four randomised controlled trials carried out by the European Vasculitis Study Group...

  12. Diversity of PR3-ANCA epitope specificity in Wegener's granulomatosis. Analysis using the biosensor technology

    NARCIS (Netherlands)

    Rarok, Agnieszka; van der Geld, Y.M.; Stegeman, Coen; Limburg, Piet; Kallenberg, Cees

    2003-01-01

    Wegener's granulomatosis is a systemic disease characterized by the presence of antineutrophil cytoplasm autoantibodies specific for proteinase 3 (PR3-ANCA). The functional characteristics of PR3-ANCA differ between quiescent and active disease, suggesting changes in the properties of the

  13. Mononeuritis multiplex as a presenting feature of Wegener granulomatosis: a case report.

    Science.gov (United States)

    Peshin, R; O'Gradaigh, D

    2007-08-01

    We report the case of a man presenting with clinical features of a mononeuritis multiplex, a perinuclear-ANCA (p-ANCA), and a renal biopsy suggestive of Wegener granulomatosis (WG). We wish to highlight this case as a learning point for clinicians as WG rarely presents in this form, and can be easily overlooked as a cause of mononeuritis multiplex.

  14. Bacterial infections in Wegener's granulomatosis : mechanisms potentially involved in autoimmune pathogenesis

    NARCIS (Netherlands)

    Tadema, Henko; Heeringa, Peter; Kallenberg, Cees G. M.

    Purpose of review Wegener's granulomatosis is associated with bacterial infection, in particular nasal carriage of Staphylococcus aureus. Infection may play a role in the induction of autoimmunity as well as in the effector phase of the disease. Here, the current hypotheses aiming to explain the

  15. Wegener's granulomatosis with unusual cavernous sinus and sella turcica extension

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, M.; Bobek-Billewicz, B. [Dept. of Radiology, Medical University of Gdansk (Poland); Bullo, B.; Hermann, A.; Rutkowski, B. [Dept. of Nephrology, Medical University of Gdansk (Poland)

    1999-07-01

    Intracerebral extension of Wegener's granulomatosis (WG) is rare. We present a patient with oculomotor and trochlear nerve palsy with histologically proved WG. An MR examination revealed granulomatous tissue in nasal cavity, paranasal sinuses with meningeal infiltration, and uncommon penetration into cavernous sinus and sella turcica. The MR images before and during pharmacological therapy are presented. (orig.)

  16. Granulomatosis with polyangiitis, a new nomenclature for Wegener's Granulomatosis - Case report*

    Science.gov (United States)

    de Lima, Alexandre Moretti; Torraca, Pedro de Freitas Silva; da Rocha, Sheila Pereira; Santiago, Carmelia Matos Reis; Ferraz, Fabio Humberto Ribeiro Paes

    2015-01-01

    The granulomatosis with polyangiitis, initially known as Wegener's granulomatosis, is a small and medium vessels vasculitis. It's classic form presents a triad: necrotizing granuloma of respiratory tract, necrotizing cutaneous vasculitis and glomerulonephritis. This vasculitis has cytoplasmic antineutrophil antibodies as signal. This work illustrates a case, of multisystemic rare disease, in which the segment and treatment were considered satisfactory for symptoms remission. PMID:26312687

  17. Wegener´s granulomatosis in a young patient preceded by localized cutaneous manifestations

    Directory of Open Access Journals (Sweden)

    Jesper Smit

    2011-10-01

    Full Text Available Wegener´s granulomatosis (WG is a rare, systemic vasculitis involving multiple organs. The clinical presentation is highly diverse, and there is considerable risk of mortality if diagnosis and treatment are delayed. We present a case illustrating that patients with WG may initially present with localized cutaneous symptoms and signs.

  18. Wegen en dammen in 't veen : onderzoek naar lichtgewicht weg- en damconstructies in veengebieden

    NARCIS (Netherlands)

    Gels, J.A.

    1989-01-01

    Aan de hand van de ervaringen komen in de conclusies en aanbevelingen schuimbeton. IMAG bodemonderzoek draagkracht veengronden en polystereen hardschuim als lichtgewicht funderingsconstructies voor wegen op veengrond naar voren in combinatie met een deklaag van in het werk gestort ongewapend of

  19. Wegener Granulomatosis with Oral Involvement as Primary Manifestation: A Case Study

    Directory of Open Access Journals (Sweden)

    Mahdokht Rashed

    2017-06-01

    Full Text Available Introduction: Wegener Granulomatosis is a rare multisystemic disease with an unknown cause, characterized by necrotic granulomatous lesions in respiratory tract, systemic vasculitis in small arteries and veins and necrotizing glomerulonephritis. Wegener can affect any organ including kidneys, eyes or other organs but classically affects upper and lower respiratory tract. One of the rare but important signs of this disease is oral involvement, generally occurring in 6-13% of patients, however, oral involvement as the primary manifestation of disease, occurs in only 5-6% of cases. The most common oral manifestation is strawberry gingivitis. Patients: Our patient was a 35 year-old man with gingival bleeding during brushing which began approximately 45 days before referring to the department of oral and maxillofacial diseases, Mashhad Dental School. In intraoral examination, his gingiva had a papillomatous appearance and was purple in color (strawberry appearance. Due to the presence of strawberry appearance in absence of plaque, primary diagnosis of Wegener granulomatosis was established and the patient was referred for histopathological evaluation. In laboratory tests, C-ANCA was positive and P-ANCA was negative. Finally, diagnosis of Wegener granulomatosis was confirmed and his treatment was started. Rheumatologic condition of patient's lungs was evaluated by chest X-ray and CT-scan and blood tests, biochemistry tests and urine analysis were performed for the patient. He did not have pulmonary or renal involvement. In our study, the patient was followed up after 1, 2 and 11 months from the first visit. Discussion: Up to now, few reports have been published on Wegener disease with oral involvement and in most of these articles, Wegener was diagnosed after respiratory symptoms and kidney or other organs involvement. Only in few studies was Wegener diagnosis confirmed on the basis of oral symptoms and gingival involvement. Immediate and aggressive

  20. Nomenclature and classification of vasculitis: lessons learned from granulomatosis with polyangiitis (Wegener's granulomatosis)

    Science.gov (United States)

    Jennette, J C

    2011-01-01

    Names influence how something is perceived. Diagnostic terms (diagnoses) are the names of diseases that are usually derived either from some distinctive characteristic of the disease or include an eponym recognizing someone who elucidated the disease. No matter how logical and appropriate a name may be, if it is not usable and used it is of no lasting value. This brief commentary focuses on the nomenclature of systemic vasculitides, and uses as a prime example Wegener's granulomatosis, which has been renamed recently ‘granulomatosis with polyangiitis’, in part because of concerns about the suitability of Friedrich Wegener as the source of an eponym. The most distinctive pathological feature of Wegener's granulomatosis is multi-focal necrotizing inflammation that has long been called granulomatosis. The systemic variant of Wegener's granulomatosis also is characterized by inflammation in many different vessels or different types, i.e. polyangiitis. Thus, granulomatosis with polyangiitis is a very appropriate alternative term for Wegener's granulomatosis. This term also is in accord with the name for a closely related vasculitis, i.e. microscopic polyangiitis. Terms that indicate aetiology and pathogenesis, when known, are useful to include in names for diseases (diagnoses). Anti-neutrophil cytoplasmic autoantibodies specific for myeloperoxidase (MPO-ANCA) or proteinase 3 (PR3-ANCA) are implicated in the cause of granulomatosis with polyangiitis and thus also should be specified in the diagnosis (e.g. PR3-ANCA-positive granulomatosis with polyangiitis or MPO-ANCA-positive microscopic polyangiitis). As our understanding of the clinical manifestations, pathogenesis and aetiology of vasculitides change over time, the names and approaches for diagnosing these diseases will change accordingly. PMID:21447122

  1. Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's)

    DEFF Research Database (Denmark)

    Cabral, David A; Canter, Debra L; Muscal, Eyal

    2016-01-01

    OBJECTIVE: To uniquely classify children with microscopic polyangiitis (MPA), to describe their demographic characteristics, presenting clinical features, and initial treatments in comparison to patients with granulomatosis with polyangiitis (Wegener's) (GPA). METHODS: The European Medicines Agen...

  2. The European Lead Fast Reactor Strategy and the Roadmap for the Demonstrator ALFRED

    International Nuclear Information System (INIS)

    Alemberti, A.; De Bruyn, D.; Grasso, G.; Mansani, L.; Mattioli, D.; Roelofs, F.

    2013-01-01

    Expected impacts: → To ensure that nuclear energy remains a long-term contributor to a low carbon economy it is necessary to increase its sustainability through demonstrating the technical, industrial and economic viability of Gen IV fast nuclear reactors; → With the construction and operation of MYRRHA and ALFRED, Europe will be in an excellent position to secure the development of a safe, sustainable and competitive fast nuclear technology; → ALFRED Demonstrator Roadmap will: • play a key role by involving European industry and maintaining and developing European leadership in nuclear technologies worldwide; • allow to investigate and address the main technological issues that can be implemented in the LFR prototype (2035); • make possible commercial deployment, by the European industry, of these technologies by 2050 and beyond; • contribute significantly to the development of a sustainable and secure energy supply for Europe from the second half of this century onwards

  3. [Alfred Adler and the psychology of aesthetic surgery in the United States].

    Science.gov (United States)

    Gilman, S L

    2002-01-01

    The quest for a psychological theory to explain the effects of aesthetic surgery reached its high point in the 1920s with the adoption of Alfred Adler's theory of the inferiority complex. The basis for this theory was Adler's early work in the psychological response of the body to disease and "degeneration". Aesthetic surgeons sought out the Adlerian model rather than a Freudian one as purely psychological while its roots, and their own theories, were clearly somatic in origin.

  4. Preface to The Diary of Vaslav Nijinsky by Alfred Adler, MD.

    Science.gov (United States)

    Ansbacher, H L

    1981-07-01

    This is a previously unpublished work by Alfred Adler that was written in 1936 as a preface to The Diary of Vaslav Nijinsky. A theory of schizophrenia is described in which characteristic prepsychotic features, especially lack of social interest and oversensitivity to real and imagined slights, lead to increasing irrationalism and preoccupation with grandiose ideas. The establishment of a cooperative therapeutic relationship and the instilling of hope are presented as central factors for successful treatment.

  5. Alfred Bentz - Erdölgeologe in schwieriger Zeit, 1938-1947

    Science.gov (United States)

    Seibold, E.; Seibold, I.

    2002-12-01

    Alfred Bentz was the leading oil geologist in Germany during the Third Reich, the World War II and thereafter. His relevant activities are treated here mainly on the base of documents in the Geologenarchiv Freiburg. In spite of his prominent position during the Nazi Regime he can obviously not be blamed for personal guilt. As a loyal civil servant he was embedded in the tragic German fate in these years.

  6. Charles Robert Darwin and Alfred Russel Wallace: their dispute over the units of selection.

    Science.gov (United States)

    Ruse, Michael

    2013-12-01

    Charles Darwin and Alfred Russel Wallace independently discovered the mechanism of natural selection for evolutionary change. However, they viewed the working of selection differently. For Darwin, selection was always focused on the benefit for the individual. For Wallace, selection was as much something of benefit for the group as for the individual. This difference is traced to their different background political-economic views, with Darwin in favor of Adam Smith's view of society and Wallace following Robert Owen in being a socialist.

  7. Spanish contribution in the design of the Alfred Reactor inside the ESNII+ Project

    Energy Technology Data Exchange (ETDEWEB)

    Romojaro, P.; García-Herranz, N.; Álvarez-Velarde, F.; López, D.

    2015-07-01

    Significant efforts are being devoted in order to boost R&D on advanced nuclear reactors due to their sustainability and improved safety characteristics. The main drawbacks for the industrial deployment of a Lead-cooled Fast Reactor (LFR) are the lack of operational experience and the technological uncertainties. In order to measure the robustness of the design and improve the safety characteristics of the ALFRED reactor -the demonstration reactor of the European LFR technology- a detailed analysis is envisaged within the EU FP7 ESNII+ project (project to support the European Sustainable Industrial Initiative) (ESNII+, 2013). One key research goal for ALFRED is the demonstration of favourable transient behaviour under accident conditions. Such behaviour depends primarily on the reactivity coefficients of the core. For evaluation of those coefficients, computational tools capable of providing results with a high level of accuracy are available. But the results will be affected by different sources of uncertainty, such as uncertainties on the engineering design, on the nuclear data, model uncertainties, etc. The objective of this work is to perform a sensitivity/uncertainty analysis of ALFRED reactor to assess the impact on the core reactivity of the uncertainties in nuclear data as well as the uncertainties in geometrical tolerances. This will allow having an exhaustive picture of their influence on the core performance, identifying key parameters and proposing specific R&D actions to achieve an improved safety level. (Author)

  8. Otomastoiditis como manifestación clínica inicial de granulomatosis de Wegener Otomastoiditis as an initial clinical manifestation of Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    Jorge De All

    2011-02-01

    Full Text Available La granulomatosis de Wegener (GW forma parte del grupo de vasculitis primarias, de vasos pequeños y medianos, asociadas a anticuerpos anticitoplasma de neutrófilos (ANCA. Esta enfermedad puede afectar cualquier órgano, especialmente vías aéreas superiores, inferiores y el riñón. Muy raramente la primera y única manifestación clínica de GW generalizada es la otomastoiditis. Presentamos el caso de un paciente que inició su enfermedad con una inflamación del oído medio, sin respuesta al tratamiento habitual. Posteriormente agregó compromiso nasal, pulmonar y renal. La determinación de anticuerpos anticitoplasma de neutrófilos y la biopsia transbronquial confirmaron el diagnóstico de GW. Comunicamos este caso para referir que la otomastoiditis del adulto, refractaria al tratamiento habitual, puede raramente ser la primera y única manifestación clínica de la GW.Wegener's granulomatosis (WG forms part of a group of primary vasculitis of the small and medium-sized blood vessels, associated with antineutrophil cytoplasmic antibodies (ANCA. This disease may affect any body organ, especially the upper and lower airways and the kidneys. Hardly ever is otomastoiditis the first and only clinical manifestation of generalized Wegener's granulomatosis. We present the case of a patient whose disease started with the inflammation of the middle ear, which was unresponsive to the usual treatment. Later he developed nasal, pulmonary and renal compromise. The determination of ANCA and a transbronchial biopsy confirmed the diagnosis of WG. We report this case to express the view that otomastoiditis in adults, which is refractory to the usual treatment, may seldom be the first and only clinical manifestation of WG.

  9. [A rare mode of revelation of Wegener's granulomatosis: myocarditis associated with a fibroblastic endocarditis].

    Science.gov (United States)

    Arous, Salim; Bensahi, Ilham; Noureddine, Malika; Habbal, Rachida

    2016-01-01

    We report, through this observation, a rare case of Wegener's disease revealed by myocarditis associated with fibroblastic endocarditis. The patient was initially admitted to hospital with global heart failure. The ECG showed atrial flutter rhythm disorder. Echocardiographic examination revealed non-dilated left ventricle with severe dysfunction and positive troponin dosage. Severe renal failure was discovered fortuitously and required hemodialysis. It was associated with an inflammatory anaemia confirmed by serum ferritin and myelogram. c-ANCA dosage was strongly positive, confirming the diagnosis. Chest CT scanning objectified right basal pneumonia. After starting appropriate treatment, including corticotherapy and immunosuppressive treatment, evolution was favorable with the normalization of left ventricular systolic function. Although obvious clinical cardiac events are rare, cardiac involvement in Wegener's disease is described, requiring rapid diagnostic orientation and rigorous knowledge of this serious disease.

  10. Management Scheme for Cerebral Wegener Granulomatosis: An Unusual Pseudotumoral Skull Base Pathology.

    Science.gov (United States)

    Bernat, Anne Laure; Lefevre, Etienne; Sène, Damien; Herman, Philippe; Biassette, Homa Adle; Froelich, Sébastien

    2016-12-01

    Granulomatosis with polyangiitis (Wegener disease) is a rare antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis that seldom involves brain and meninges. We present a case of a 35-year-old woman with granulomatosis with polyangiitis involving the brain and the meninges. The histologic diagnosis required a complete resection of the lesion. Despite the possibility of postoperative wound infection, surgery was mandatory to ascertain the diagnostic and to treat locally. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Pial involvement in Wegener's granulomatosis shown on MRI

    Energy Technology Data Exchange (ETDEWEB)

    Nusbaum, A.O. [Mount Sinai Hospital, New York (United States). Dept. of Radiology; Morgello, S.; Atlas, S.W. [Mount Sinai School of Medicine, New York (United States). Dept. of Pathology

    1999-11-01

    Involvement of the brain and meninges is rare in Wegener's granulomatosis (WG); it has been reported in 1.2-8 % of patients. Meningeal involvement in WG has been reported in imaging as being confined to the duramater, and is thought to represent granulomatous infiltration. We present a case of WG with abnormal pial enhancement and involvement of the perivascular spaces on MRI, pathologically proven to represent granulomatous infiltration due to the primary disease rather than to infection. (orig.)

  12. CT findings of sinonasal and orbital Wegener's granulomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Ri, Kyoushichi; Kushihashi, Tamio; Munechika, Hirotsugu (Showa Univ., Tokyo (Japan). School of Medicine) (and others)

    1994-02-01

    We reviewed the CT findings of four cases of Wegener's granulomatosis that presented as inflammatory masses in the sinonasal cavity or orbit. In the present study, an infiltrative nature and homogeneous texture with contrast enhancement were typical of the masses. In addition, the masses were frequently accompanied by infiltration of the pterygopalatine fossa or destruction of adjacent bone. However, no pathognomonic findings were observed. (author).

  13. Incidence of granulomatosis with polyangiitis (Wegener's) in Greenland and the Faroe Islands

    DEFF Research Database (Denmark)

    Faurschou, M; Helleberg, M; Obel, N

    2013-01-01

    Previous studies suggest that the incidence of granulomatosis with polyangiitis (Wegener's; GPA) increases along a south-north gradient in the Northern Hemisphere with an incidence of 8.0/million/year reported for the population of Northern Norway. In the present study, we assessed the incidence...... of GPA in the predominantly Inuit population of Greenland and in the Caucasian population of the Faroe Islands....

  14. [A case of pulmonary-limited Wegener granulomatosis mimicking bacterial pneumonia caused by Staphylococcus aureus].

    Science.gov (United States)

    Ugajin, Motoi; Miwa, Seiichi; Suda, Takafumi; Shirai, Masahiro; Hayakawa, Hiroshi; Chida, Kingo

    2011-04-01

    A 56-year-old woman who had suffered from systemic lupus erythematosus and Sjögren syndrome was admitted complaining of persistent cough. Chest X-ray films showed an infiltrative shadow in the right middle lung field. Her serum PR3-ANCA titer was high, and granulomatous inflammation with Langhans giant cell was noted in a transbronchial biopsy specimen. About 3 months later, purulent sputum and high grade fever developed, with a new infiltrative shadow in the left upper lung field noted on a chest X-ray film. We treated her based on a diagnosis of bacterial pneumonia caused by methicillin-resistant Staphylococcus aureus, but her condition did not improve. We finally gave her a diagnosis of pulmonary-limited Wegener's granulomatosis. Her condition improved with the administration of sulfamethoxazole-trimethoprim, prednisolone and cyclophosphamide. We report a case of pulmonary-limited Wegener granulomatosis which mimicked bacterial pneumonia caused by methicillin-resistant Staphylococcus aureus. This case suggests that Wegener's granulomatosis should be considered on encountering pneumonia caused by Staphylococcus aureus.

  15. Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Soo; Kim, Tae Sung; Kim, Eun A. [Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710 (Korea); Fujimoto, Kiminori [Department of Radiology, Kurume University School of Medicine, Kurume 830-0011 (Japan); Moriya, Hiroshi [Department of Radiology, Fukushima Medical University School of Medicine, Fukushima 960-1295 (Japan); Watanabe, Hideyuki [Department of Radiology, University of Occupational and Environmental Health, Japan School of Medicine, Kitakyushu 807-8555 (Japan); Tateishi, Ukihide [Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638 (Japan); Ashizawa, Kazuoto [Department of Radiology, Nagasaki University School of Medicine, Nagasaki 852-8501 (Japan); Johkoh, Takeshi [Department of Radiology, Osaka University Graduate School of Medicine, Suita 565-0871 (Japan); Kwon, O. Jung [Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710 (Korea)

    2003-01-01

    Our objective was to describe the CT findings of thoracic Wegener's granulomatosis. At presentation, both conventional and thin-section CT scans were available in 30 patients with Wegener's granulomatosis. Serial CT scans (range of intervals: 1-25 months, mean 4.5 months) were available in 20 patients. The initial and follow-up CT scans were analyzed retrospectively by two observers in terms of pattern and extent of parenchymal and airway lesions. Positive CT findings were seen in 29 of 30 (97%) patients at initial presentation. The most common pattern was nodules or masses seen in 27 of 30 (90%) patients. They were multiple in 23 of 27 (85%) patients, bilateral in 18 (67%), subpleural in 24 (89%), and peribronchovascular in 11 (41%) in distribution. Bronchial wall thickening in the segmental or subsegmental bronchi was seen in 22 (73%) patients. Large airways were also abnormal in 9 (30%) patients. Patchy areas of consolidation and ground-glass opacity were seen in 7 (23%) patients, respectively. In 17 of 20 (85%) patients in whom follow-up CT scans were available, the parenchymal or airway lesion showed complete or partial improvement with treatment. The CT findings of Wegener's granulomatosis, although multiple and variable, consist mainly of bilateral subpleural or peribronchovascular nodules or masses and bronchial wall thickening in the segmental or subsegmental bronchi. Parenchymal and airway lesions improve with treatment in most patients. (orig.)

  16. The Archaeology and Pottery of Nazca, Peru. Alfred L. Kroeber's 1926 Expedition. Alfred L Kroeber and Donald Collier. edited by Patrick H. Carmichael, Walnut Creek: Altamira Press, 1998

    Directory of Open Access Journals (Sweden)

    David L. Browman

    2000-05-01

    Full Text Available This volume is the much delayed publication of the results of the Second Marshall Field Archaeological Expedition to Peru in 1926, sponsored by the Field Museum of Natural History in Chicago, and con­ducted by Alfred Kroeber(1876-1960. It contains some useful short "history of the discipline" remarks both in the preface by Carmichael and in the draft introduction to the original manuscript by Kroeber and Collier. Donald Collier (1911-1995, was curator at the Field Museum from 1941 to 1976, and was working with Kroeber in the late 1950s to help bring the report out, but work stopped with Kroeber's death in 1960. Carmichael ran across the unfinished manuscript in the Field Museum in 1986 while do­ing research on the Nazca assemblages as a graduate student, and with Collier's permission and assis­tance, reassembled the component parts and edited the manuscript for publication.

  17. Esclerite como manifestação inicial de granulomatose de Wegener: descrição de caso Wegener's granulomatosis presenting as scleritis: case report

    Directory of Open Access Journals (Sweden)

    Leonardo Schmidt

    2007-04-01

    Full Text Available Esclerite é um processo inflamatório ocular caracterizado por edema e infiltração celular da esclera, que cursa com vermelhidão e dor locais e causa perda importante da acuidade visual. Pode ser a primeira manifestação de uma doença reumática sistêmica como lúpus, artrite reumatóide e policondrite recidivante, embora seja mais comum que apareça bastante tempo depois da doença já estabelecida. Os autores apresentam um caso de granulomatose de Wegener no qual essa forma de envolvimento ocular precedeu o aparecimento de glomerulonefrite em 18 meses.Scleritis is an ocular inflammatory condition characterized by edema and cellular infiltration of the sclera that causes local redness, pain and loss of visual acuity. It can be the first manifestation of a systemic rheumatic disease such as lupus, rheumatoid arthritis and relapsing polycondritis, although it is more frequently found in a well established disease. The authors describe a case of Wegener's granulomatosis where this form of ocular involvement preceded the glomerulonephritis by eighteen months.

  18. Cuidar em oncologia na perspectiva de Alfred Schütz Cuidado en oncología segundo Alfred Schütz Oncological care according Alfred Schütz

    Directory of Open Access Journals (Sweden)

    Regina Célia Popim

    2005-10-01

    Full Text Available O estudo foi realizado com enfermeiros oncológicos em seu cotidiano de trabalho. O objetivo foi compreender a ação subjetiva desses profissionais a partir de sua relação enfermeiro-doente. O referencial fenomenológico, fundamentado nas idéias de Alfred Schütz, possibilitou essa compreensão. Diante de uma questão orientadora: o que significa para você cuidar em oncologia? descreva para mim, foram obtidos depoimentos, os quais, depois de analisados, permitiram chegar ao típico da ação do cuidador enfermeiro neste cotidiano. O estudo revelou que cuidar em oncologia implica em lidar com o humano em situação de fragilidade; requer uma relação de afetividade; é um cuidado que traz consigo a gênese do desgaste profissional. O cuidado em oncologia reveste-se de grande complexidade, requerendo do profissional uma competência que vai para além da esfera técnico-científica. Nesse sentido, o enfermeiro necessita buscar por estratégias que lhe possibilitem o enfrentamento do desgaste a que é submetido em seu trabalho.El estudio fue realizado con enfermeros oncológicos en su cotidiano de trabajo. El objetivo fue comprender la acción subjetiva de esos profesionales desde la relación enfermero-enfermo. El referencial fenomenológico, fundamentado en las ideas de Alfred Schütz, posibilitó esa comprensión. Delante de una cuestión orientadora: ¿qué significa para usted el cuidado en oncología? Descríbame, se obtuvo declaraciones que, tras análisis, permitieron llegar a lo que es típico en la acción cotidiana del cuidador enfermero. El estudio reveló que cuidar en oncología implica tratar con el ser humano en situación de fragilidad; requiere una relación de afectividad; es un cuidado que trae consigo la génesis del desgaste profesional. El cuidado en oncología se reviste de gran complejidad y requiere del profesional una competencia que va más allá de la esfera técnico-científica. En ese sentido, el enfermero

  19. Antiproteinase 3 antineutrophil cytoplasmic antibodies and disease activity in Wegener granulomatosis.

    Science.gov (United States)

    Finkielman, Javier D; Merkel, Peter A; Schroeder, Darrell; Hoffman, Gary S; Spiera, Robert; St Clair, E William; Davis, John C; McCune, W Joseph; Lears, Andrea K; Ytterberg, Steven R; Hummel, Amber M; Viss, Margaret A; Peikert, Tobias; Stone, John H; Specks, Ulrich

    2007-11-06

    The utility of antineutrophil cytoplasmic antibody (ANCA) levels to guide the management of patients with Wegener granulomatosis remains controversial. To determine whether pro-proteinase 3 (PR3)-ANCA levels are a better measure of disease activity than mature-PR3-ANCA levels, whether decreases in either level are associated with shorter time to remission, and whether increases are followed by relapse. Prospective, observational cohort study. 8 United States medical centers that participated in a treatment trial for Wegener granulomatosis. 156 patients with Wegener granulomatosis enrolled during periods of active disease. PR3-ANCA levels (by capture enzyme-linked immunosorbent assay) and disease activity (by the Birmingham Vasculitis Activity Score for Wegener granulomatosis). The ANCA levels were only weakly associated with disease activity across patients. The longitudinal association within patients was stronger, but changes in ANCA levels explained less than 10% of the variation in disease activity. Decreases in mature- and pro-PR3-ANCA levels were not statistically significantly associated with shorter time to remission, and increases in mature-PR3-ANCA levels (adjusted hazard ratio, 0.8 [95% CI, 0.4 to 1.9]; P = 0.67) and pro-PR3-ANCA levels (adjusted hazard ratio, 1.0 [CI, 0.5 to 2.1]; P = 0.99) were not associated with relapse. The proportion of patients who had relapse within 1 year of an increase in PR3-ANCA levels was 40% for mature-PR3 (CI, 18% to 56%) and 43% for pro-PR3 (CI, 22% to 58%). Samples were collected approximately every 3 months. Sensitivity and specificity of ANCA levels for detecting remission and relapse could not be calculated because each patient had different follow-up times. Pro-PR3-ANCA is no better than mature-PR3-ANCA as a measure of Wegener granulomatosis activity. Decreases in PR3-ANCA levels are not associated with shorter time to remission, and increases are not associated with relapse. These findings suggest that ANCA levels

  20. [Doctor and poet as rivals. Sigmund Freud, Alfred von Berger and the narrative of female homosexuality].

    Science.gov (United States)

    Goldmann, Stefan

    2011-01-01

    Starting from a passage in the Dora case history where Freud suggests some differences between a literary and a clinical narrative of female homosexuality, this paper presents examples which he might have had in mind. Besides Balzac's "La fille aux yeux d'or" (1834/35) it is in particular Alfred v. Berger's novella "Die Italienerin [The Italian woman]" (1904) which may have served as a model and counterpoint to the literary strategies used in Freud's case history. Freud had a relationship of long standing with Berger. This newly discovered source may provide a clue for the date at which Freud finalized the Dora manscript which he had held back for years.

  1. Alfred Marshall y el Banco Central: política monetaria

    OpenAIRE

    Fernando Méndez Ibisate

    1994-01-01

    Editada en la Fundación Empresa Pública Como resultado de sus contribuciones a la teoría monetaria, Alfred Marshall propuso una renovación institucional decisiva dentro del sistema monetario: defendió un sistema de banca central con argumentos más racionales que los de sus predecesores —especialmente Walter Bagehot— y concedió un papel mucho más importante a la autoridad monetaria en el control de la política monetaria (especialmente en la lucha anticíclica). Marshall no contempló el siste...

  2. Alfred Rosenberg und die Nordische Gesellschaft – Der „nordische Gedanke“ in Theorie und Praxis

    Directory of Open Access Journals (Sweden)

    Birgitta Almgren; Jan Hecker-Stampehl; Ernst Piper

    2008-12-01

    Full Text Available This contribution traces the emergence, Gleichschaltung, expansion and demise of the Nordische Gesellschaft [Nordic Society] with a special focus on its leading protagonist Alfred Rosenberg. In the beginning of the article, the history of ideas and the organisa-tional foundations of the society are being set as a background. In the main part of the text the Nordische Gesellschaft’s activity during the “Third Reich” and under Rosenberg’s auspices is being analysed. Sources used comprise both archival material as well as the NG’s own publications

  3. Alfred Werner's role in the mid-20th century flourishing of American inorganic chemistry.

    Science.gov (United States)

    Labinger, Jay A

    2014-01-01

    The development of organic and physical chemistry as specialist fields, during the middle and end of the 19th century respectively, left inorganic behind as a decidedly less highly regarded subfield of chemistry. Despite Alfred Werner's groundbreaking studies of coordination chemistry in the early 20th century, that inferior status remained in place - particularly in the US - until the 1950s, when the beginnings of a resurgence that eventually restored its parity with the other subfields can be clearly observed. This paper explores the extent to which Werner's heritage - both direct, in the form of academic descendants, and indirect - contributed to those advances.

  4. Visionen von Natur vor uns. Alfred Ehrhardt fotografiert und filmt Urformen der Natur

    Directory of Open Access Journals (Sweden)

    Sabine Wilke

    2015-11-01

    Full Text Available What did nature look like before it was destroyed by modern civilization? That is a question that was at the center of modernist art photography. It also resonates today in the context of environmental debates. On the example of the art work of Bauhaus photographer and cinematographer Alfred Ehrhardt, the artistic project of portraying nature “before us” is analyzed as an aesthetic project that positions itself before and next to the Anthropocene, i.e., the geological concept that foregrounds a radical interconnectivity between humans and nonhuman nature in our post-industrial era of mankind.

  5. Alfred Werner

    Indian Academy of Sciences (India)

    experimentally by investigations of a very large number of molecular compounds which are now ~alled complex ... compounds must not invariably correspond to the maximum coordination number of the centre atom ... discovered first in the platinum series and then in the cobalt series, occupied my mind for many years, and ...

  6. Comprehensive approach of nursing: possibility of interpretation based on alfred schutz

    Directory of Open Access Journals (Sweden)

    Pétala Tuani Candido de Oliveira Salvador

    2014-01-01

    Full Text Available Objetivo: Refletir acerca da abordagem compreensiva da enfermagem a partir do referencial teórico de Alfred Schutz. Métodos: Estudo reflexivo, tecido à luz da fenomenologia sociológica compreensiva de Alfred Schutz. Resultados: São tecidas reflexões sobre a interpretação do cuidado de enfermagem a partir dos conceitos chave de Schutz, destacando-se: o cuidar a partir da tipificação do outro, que reconhece o mundo vida cotidiano dos sujeitos, que busca a intersubjetividade e que estabelece uma relação face a face. Reflete-se ainda acerca dos motivos-para e motivos-porque da prática de enfermagem. Conclusão: Conclui-se que a tipificação da prática de enfermagem traduz-se na compreensão de uma profissão essencialmente complexa, que se fundamenta no cuidar como elemento medular de suas práticas.

  7. Reversible complete atrioventricular block in patient with wegener's granulomatosis - a report on fortunate outcome with long term follow-up.

    Science.gov (United States)

    Steckiewicz, Roman; Rosiak, Marek; Stolarz, Przemysław; Świętoń, Elżbieta B; Grabowski, Marcin; Kosior, Dariusz A

    Reversible complete atrioventricular block in patient with Wegener's granulomatosis - a report on a positive outcome with long term follow-up. Atrioventricular (AV) block is a rare complication of Wegener's granulomatosis (WG), thus there are no standards of management in such cases. We present a case of a patient with a dual-chamber pacemaker (DDD) implanted due to complete AV block in the course of Wegener's granulomatosis (WG). An immunosuppressive therapy resulted in the resolution of non-cardiac and AV conduction disorders. The diagnostic functions of the pacemaker enabled us to evaluate AV conduction over a five-year follow-up period. The resolution of AV conduction disorders, which accompanied WG remission, suggests that careful monitoring with temporary cardiac pacing may be considered in some patients before permanent pacemaker implantation.

  8. [Wegener's granulomatosis: an often difficult diagnosis. Apropos of a case with digestive localization but without lung or kidney involvement].

    Science.gov (United States)

    El Fehri, F; Salih-Alj, A; Kzadri, M; Zemmama, M; Alaoui, H; Marandas, P; Jazouli, N

    1983-01-01

    Even if Wegener's disease is a rare condition, it interests many authors. Many recent reports had contributed to a best knowledge of the disease. Nevertheless, it persists a number of questions without yet an answer. In this paper, for example, we present a case of Wegener's granulomatosis, which mimics in the beginning the so-called "lethal midline granuloma", with progressive ulceration of the midfacial tissues and nose. It was highly suspected of being stewart's syndrome--Repeated biopsies gave no evidence of diagnosis. At least, the diagnosis was affirmed only by laparotomy. Pathological findings were typical of Wegener's granulomatosis with lesions interesting the sole digestive tract, lacking the characteristical chest and kidney involvement. The authors insist on the difficulties of the diagnosis, the etiologic considerations, and a better definition and classification of the affection.

  9. Manifestação otológica localizada em paciente com granulomatose de Wegener Localized otologic manifestation in a patient with Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    Márcia Regina Rosa Scalcon

    2008-08-01

    Full Text Available A granulomatose de Wegener (GW é uma vasculite granulomatosa multissistêmica rara, idiopática, que acomete vasos de pequeno e médio calibres, e que classicamente envolvem os tratos respiratórios superior, inferior e rins. Na forma limitada da doença, diversos sítios anatômicos podem ser afetados isoladamente. Foi descrito o caso de uma paciente jovem, que iniciou o acometimento da GW por dispnéia, estridor laríngeo e hipacusia. A investigação evidenciou o acometimento localizado na glote, e envolvimento da membrana timpânica comprovado por biópsia. A paciente obteve resposta com o tratamento instituído, mas permaneceu com seqüelas otológicas. Revisa-se neste artigo algumas das manifestações focais da GW, salientando especialmente as manifestações otológicas.Wegener's granulomatosis (WG is a rare, idiopathic granulomatous vasculitis, affecting small and medium-sized vessels, classically involving upper and lower respiratory tracts and kidneys. In the limited form of the disease, several other sites can be affected. We describe the case of a young woman who presented her disease with dyspnea, laryngeal stridor and hearing loss. Investigation revealed localized glottis involvement and a tympanum biopsy confirmed granulomatous vasculitis. The patient had a partial response with the treatment, with residual deafness. We performed a review concerning the focal manifestations of WG, focusing in the ear involvement.

  10. Plasma exchange for induction and cyclosporine A for maintenance of remission in Wegener's granulomatosis--a clinical randomized controlled trial

    DEFF Research Database (Denmark)

    Szpirt, Wladimir M; Heaf, James G; Petersen, Jørgen

    2011-01-01

    The use of plasma exchange (PE) for induction treatment of anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis (AAV), including Wegener's granulomatosis (WG), is still controversial. The use of PE in AAV is not commonly accepted in patients with a plasma creatinine......The use of plasma exchange (PE) for induction treatment of anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis (AAV), including Wegener's granulomatosis (WG), is still controversial. The use of PE in AAV is not commonly accepted in patients with a plasma creatinine...

  11. Granulomatous renal pseudotumor in Wegener's granulomatosis: imaging findings in one case

    Energy Technology Data Exchange (ETDEWEB)

    Verswijvel, G.; Eerens, I.; Oyen, R. [Department of Radiology, University Hospitals. Catholic University of Leuven, Leuven (Belgium); Messiaen, T. [Department of Nephrology, University Hospitals. Catholic University of Leuven, Leuven (Belgium)

    2000-08-01

    Wegener's granulomatosis is a clinico-pathological entity characterized by necrotizing granulomatous angiitis involving the upper- and/or lower respiratory tract and the kidneys. Renal involvement is usually characterized by a rapidly progressive necrotizing glomerulonephritis. A case is presented of a patient who developed renal failure and presented a solitary pseudotumoral lesion in the upper pole of the left kidney. Imaging characteristics on US, CT and MR imaging are discussed. The diagnosis was confirmed with ultrasound-guided needle biopsy. (orig.)

  12. Indium-111 leukocyte scintigraphy in Wegener's granulomatosis involving the spleen

    Energy Technology Data Exchange (ETDEWEB)

    Morayati, S.J.; Fink-Bennett, D.

    1986-12-01

    Indium-111-labeled leukocyte scintigraphy was performed on a 44-yr-old man to exclude an occult abscess. Four- and twenty-four-hour images of the abdomen revealed splenic photopenia except for a rim of activity medially. A subsequent computed tomography (CT) study demonstrated necrosis or hemorrhage of the spleen except for a medial rim. Exploratory laparotomy demonstrated necrotizing vasculitis with granuloma formation consistent with Wegener's granulomatosis and a rim of viable splenic tissue corresponding to the radionuclide and CT studies.

  13. Upper Respiratory Tract Symptoms, Renal Involvement and Vasculitis: A Case Report and Review of Wegener Granulomatosis

    Science.gov (United States)

    Said, Mohd Shahrir Mohamed

    2010-01-01

    Wegener’s Granulomatosis is a condition associated with systemic vasculitis which can present with upper respiratory tract symptoms initially. On September 2001, a 15-year-old girl presented with symptoms of nasal block for 3 weeks. She later developed joint pains and worsening renal status requiring dialysis. A renal biopsy was performed which showed pauci-immune cresentric glomerulonephritis. Her cANCA levels were positive. She was treated with oral cyclophosphamide and steroids and later responded. Keywords Wegener granulomatosis; Young girl; Cyclophophamide; cANCA PMID:21629538

  14. Orbital tumour due rhinosinusal extension in a patient with Wegener's granulomatosis.

    Science.gov (United States)

    Molina-Sócola, F E; Galván-Carrasco, M P; Del Estad-Cabello, A; Sánchez-Vicente, J L; Contreras-Díaz, M; Rueda-Rueda, T

    2016-09-01

    The case is presented of a 49 year-old woman with an orbital mass originating from the rhinosinus. She had a history of Wegener's granulomatosis, refractory to both biological and immunosuppressive therapy. Clinical examination showed proptosis, diplopia, and restriction of ocular movements. Orbital mass resection was performed, due to its rapid growth, and lack of response to medical treatment. Copyright © 2016 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  15. Lingual infarction in Wegener's Granulomatosis: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Brizman Eitan

    2008-08-01

    Full Text Available Abstract Wegener's granulomatosis (WG is a multi-system disease, characterised by the triad of necrotising granulomata affecting the upper and lower respiratory tracts, disseminated vasculitis and glomerulonephritis. Oral lesions are associated with up to 50% of cases, although are rare as a presenting feature. The most common oral lesions associated with WG are ulceration and strawberry gingivitis. We review the literature regarding oral manifestations of WG and present a case of lingual infarction, an extremely rare oral lesion associated with WG, in a severe, rapidly progressive and ultimately fatal form of the disease.

  16. 'KROLL, Frank-Lothar, Die Hohenzollern'

    OpenAIRE

    Olivier, Mathieu

    2013-01-01

    La parution d’une brève mise au point sur la dynastie Hohenzollern dans le cadre de la collection Wissen, que l’auteur prend soin de placer dans le contexte historiographique du renouveau général d’une histoire dynastique vouée aux gémonies il n’y a pas si longtemps encore, est à saluer. On ne peut qu’adhérer, de surcroît, aux choix d’exposition et de périodisation de l’auteur, logiques et pour tout dire attendus. C’est ainsi que la transformation de la modeste principauté brandebourgeoise en...

  17. Total nasal skeletal reconstruction disfigured by granulomatosis with polyangitis (wegener granulomatosis).

    Science.gov (United States)

    Hafezi, Farhad; Naghibzadeh, Bijan; Ashtiani, Abbas Kazemi; Nouhi, Amir Hossein; Naghibzadeh, Ghazal

    2015-02-01

    Nasal deformity is a common disorder in Wegener granulomatosis, which is produced by polyangitis of medium-sized vessels. This process may cause necrosis and destruction of the nasal mucosa and osteocartilaginous framework. At this time, there is a lack of published data on nasal deformities associated with Wegener granulomatosis. We present a 53-year-old woman with completely necrotized nasal lining and osteocartilage. The patient had a history of granulomatosis with polyangitis that was currently in remission. We reconstructed the patient's nose with fifth and sixth rib cartilages over 3 successive surgeries over a 2-year period. During the 3-year follow-up period, neither infection nor significant cartilage graft resorption was observed, and the aesthetic result was acceptable both to the patient and her physicians. In spite of contamination to the nasal lining and immune-compromising medications, nasal reconstruction is usually successful when considering these factors. Access to strong and abundant fifth or sixth rib cartilage presents an opportunity to reconstruct nasal destruction due to iatrogenic or autoimmune processes.

  18. WegenerNet climate station network region Feldbach, Austria: network structure, processing system, and example results

    Directory of Open Access Journals (Sweden)

    T. Kabas

    2011-03-01

    Full Text Available The WegenerNet climate station network is a pioneering weather and climate observation experiment at very high resolution in southeastern Austria. The network comprises 151 meteorological stations within a limited area of approximately 20 km × 15 km centered near the town of Feldbach. Measurements include the parameters air temperature, relative humidity, precipitation amount, and others at selected stations (e.g. wind and soil parameters. The temporal sampling is 5 min except 30 min sampling of soil measurements. All data pass a Quality Control System and the provided data products include station data (~1.4 km × 1.4 km grid and gridded data (1 km × 1 km and 0.01° × 0.01° grids on various temporal scales (from 5 min to annual. For application purposes all data are available in near real time (data latency less than 1–2 h in standard operation via the WegenerNet data portal (www.wegenernet.org.

  19. Therapeutic implications of coexisting severe pulmonary hemorrhage and pulmonary emboli in a case of Wegener granulomatosis.

    Science.gov (United States)

    Dreyer, Gavin; Fan, Stanley

    2009-05-01

    Wegener granulomatosis classically involves the renal, respiratory, and ear, nose, and throat systems. Pulmonary hemorrhage is recognized as a severe respiratory complication. Untreated, the mortality rate approaches 90% at 2 years. We describe a case of Wegener granulomatosis with coexistent severe lung hemorrhage and pulmonary and deep vein thromboses. A 31-year-old man presented with features of vasculitis, including epistaxis, fever, and acute kidney injury with an increased serum creatinine level (3.27 mg/dL). Kidney biopsy confirmed pauci-immune crescentic glomerulonephritis, and antineutrophil cytoplasmic antibody showing a cytoplasmic staining pattern was strongly positive. Standard immunosuppression therapy (prednisolone and cyclophosphamide) was started. Eleven days later, the patient developed sudden dyspnea. A computed tomographic pulmonary angiogram showed pulmonary emboli, and ultrasound of the limbs showed ileofemoral thrombi bilaterally. Subcutaneous enoxaparin and warfarin therapy was started, but 8 days later, the patient had a massive pulmonary hemorrhage. Anticoagulation therapy was stopped, and plasma exchange was started to prevent further life-threatening hemorrhage. An inferior vena cava filter was inserted to prevent further pulmonary emboli during the period when anticoagulation was withheld. Kidney function improved, and pulmonary hemorrhage resolved after 5 plasma exchanges. Reintroduction of intravenous heparin and subsequently warfarin caused no further bleeding. We discuss the difficult management dilemma this combination of disease manifestations presents and review the current literature.

  20. Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation.

    Science.gov (United States)

    Martinez, Felipe; Chung, Jonathan H; Digumarthy, Subba R; Kanne, Jeffrey P; Abbott, Gerald F; Shepard, Jo-Anne O; Mark, Eugene J; Sharma, Amita

    2012-01-01

    Wegener granulomatosis is an uncommon necrotizing vasculitis that classically manifests as a clinical triad consisting of upper and lower airway involvement and glomerulonephritis. Other less frequently involved organ systems include the central and peripheral nervous system and large joints. The diagnosis is based on a combination of clinical and laboratory findings. Because thoracic involvement often predominates, chest radiographic findings are often the first to suggest the diagnosis. However, chest computed tomography (CT) has superior sensitivity and specificity for evaluation of the airways, lung parenchyma, and mediastinum, particularly with the use of multiplanar reformatted and three-dimensional images. Common pulmonary radiologic findings include waxing and waning nodules, masses, ground-glass opacities, and consolidation. Airway involvement is usually characterized by circumferential tracheobronchial thickening, which can be smooth or nodular. Pleural effusions are the most common manifestation of pleural disease and can result from primary involvement or be secondary to renal failure. Mediastinal lymphadenopathy is a nonspecific finding and is usually reactive. Uncommon thoracic radiologic manifestations include involvement of the heart and great vessels. CT is the imaging modality of choice for diagnosis, surveillance, and follow-up in patients with Wegener granulomatosis. © RSNA, 2012.

  1. Discussion of Alfred Alder's preface to The Diary of Vaslav Nijinsky.

    Science.gov (United States)

    Ansbacher, H L

    1981-07-01

    In his preface to The Diary of Vaslav Nijinsky, Alfred Adler (1) found his theory of the dynamics of schizophrenia supported in the Diary, (2) alluded to Nijinsky's prepsychotic personality, and (3) briefly touched on the possibility and conditions of recovery. To add to the understanding of Adler's "Preface," this discussion (1) expands his theory of schizophrenia, (2) gives some concrete data of Nijinsky's prepsychotic personality, (3) describes two episodes of recovery subsequent to the "Preface," and (4) introduces an important aspect of Adler's theory, which he had to omit out of consideration for Nijinsky's wife, Romola-namely, her role in her husband's disorder. With the larger theoretical and historical context established. Adler's "Preface" can be appreciated for its predictive validity.

  2. Arte e identidad. En torno a la obra del artista Alfred Kubin

    OpenAIRE

    Llinares Chover, Joan B.

    1999-01-01

    Alfred Leopold Isidor Kubin nació en Leitmeritz, Bohemia, en 1877, y falleció en 1959 en Zwickledt, Austria, en el pequeño castillo de su propiedad en el que residía desde el otoño de 1906. Su obra goza de alta estima, sobre todo en el área cultural germánica, tanto en su faceta plástica, pues Kubin fue un reconocido pintor, dibujante e ilustrador de gran producción, insólita originalidad y constantes colaboraciones gráficas a lo largo de más de 60 años, como en su vertiente literaria, porque...

  3. COMIC AGENTS: FROM A POETIC TO AN ANTHROPOLOGICAL PARADIGM OF COMEDY (ARISTOTLE AND ALFRED GELL

    Directory of Open Access Journals (Sweden)

    ANNA KAWALEC

    2016-05-01

    Full Text Available Aristotle was concerned with the comedy genre as a kind of poetry. Its creators, the comic poets, interested him only marginally. This genological approach to its subject-matter dominated the theory and philosophy of art for subsequent centuries as evidenced by the subsequent elaborations of interpretations of Aristotle’s catharsis. The alternative approach focused instead on subjects as creators of art. As a consequence of the long-term development of anthropocentrism in the humanities, however, this approach took over. The “ performative turn” represents its more recent version. It allows one to interpret Poetics and other classical works not in the context of an object (comedy, but in the context of the acting subject. I claim that social anthropology further explores the concept of comedy and itself presumes it in its conceptual foundations and research approach. I elaborate the argument on the basis of the concept of the “spirit of comedy” coined by Alfred Gell .

  4. The aerial view of Cordoba drawn by Alfred Guesdon in 1853

    Directory of Open Access Journals (Sweden)

    Antonio Gámiz Gordo

    2018-02-01

    Full Text Available The aerial views by Alfred Guesdon are considered works of special interest due to their quality and beauty. These drawings are a faithful portrait of the great cities of the period, and a mystery in terms of their creation. After reviewing some of the aerial drawings of the mid-19th century, the author considers undocumented hypotheses regarding the relationship of Charles Clifford to the drawings by Guesdon of Spanish cities, and the issues related to their elaboration by means of plans, photographs and hot-air balloons. Some light is shed on this matter thanks to the unpublished drawing of the city of Cordoba (1853, whose accuracy is evident when compared to a city plan drawn by Montis (1851. A journey through the city of Cordoba and its landmarks proves the documentary value of the drawing by Guesdon, who knew how to combine traditional drawing skills with the latest technical advances of his time.

  5. Tumour necrosis factor-alpha (TNF), lymphotoxin and TNF receptor levels in serum from patients with Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Jónasdóttir, O; Petersen, J; Bendtzen, K

    2001-01-01

    Wegener's granulomatosis (WG) is a systemic inflammatory disease with vasculitis as the key feature. Abnormal expression of tumour necrosis factor alpha (TNFalpha) is considered of prime pathogenic importance in several inflammatory diseases. The effects of TNFa are mediated by TNF receptors (TNF...

  6. De keuze van de steekproef ten behoeve van het SWOV-project "Kencijfers voor de verkeersveiligheid van wegen".

    NARCIS (Netherlands)

    Minnen, J. van

    1987-01-01

    In the framework of the SWOV-research: "kencijfers voor de verkeersveiligheid van wegen "an inventory is made of the characteristics of the road, traffic and accidents of the main road network. The sequence of it is an inventory of secondary and tertiary roads outside built-up areas. As this would

  7. Granulomatose de Wegener – Envolvimento otológico, nasal, laringotraqueal e pulmonar

    Directory of Open Access Journals (Sweden)

    Sandra Figueiredo

    2009-09-01

    Full Text Available Resumo: A granulomatose de Wegener é uma vasculite sistémica rara e idiopática caracterizada pelo atingimento dos pequenos vasos. A doença atinge, preferencialmente, as vias aérea superior e inferior e os rins, levando à formação de granulomas e necrose destes órgãos. As manifestações clínicas e o envolvimento orgânico variam largamente. O diagnóstico e tratamento precoce podem levar à recuperação total. No entanto, o atraso no diagnóstico pode ser fatal. Os autores apresentam o caso de uma doente de 33 anos com uma forma de apresentação grave e rara da doença, mas com uma evolução favorável após diagnóstico e tratamento adequado. Abstract: Wegener granulomatosis is a rare systemic idiopathic disease characterized by involvement of small vessels – medium and small arteries, venules, arterioles and ocasionally large arteries. This disease has predilection for the upper and lower respiratory tract and the kidney, with granulomatous inflamation and necrosis. Clinical manifestations and organ involvement of the disease vary widely. Early diagnosis and treatment may lead to a full recovery. Without treatment, Wegener's granulomatosis can be fatal. The authors present a case of a 33 year-old female, with severe disease, but with good outcome, after adequate diagnosis and treatment. Palavras-chave: Granulomatose de Wegener, forma limitada grave, Key-words: Wegeneŕs granulomatosis, severe limited form

  8. [A historic case of Wegener's granulomatosis: the physicist who discovered the electromagnetic waves: Heinrich Hertz].

    Science.gov (United States)

    Feldmann, H

    2005-06-01

    A diary and an extensive correspondence of Heinrich Hertz and his family provide a meticulous documentation of his life, made available by Albrecht Folsing in 1997 through a carefully investigated biography, which permit the conclusion that H. Hertz died of Wegener's granulomatosis, 45 years before this disease had been explored. WEGENER'S GRANULOMATOSIS: The symptoms of the granulomatosis, that was first described by Friedrich Wegener in 1936 and 1939 are presented in short with literal quotations of the author: It begins with a refractory cold that will last until the end, then follow involvement of the paranasal sinuses, ears, mucous lining of mouth and pharynx, slight fever, weakness, in the final phase dissemination with nephritis, septic fever, arthritis, myalgia, paralyses leading to total immobility, exitus. The etiology is not fully understood but probably based on immunoreaction. H. HERTZ: CURRICULUM VITAE: Born in Hamburg, Germany, in 1857: after secondary school academic training in physics at Dresden, Munic and Berlin. 1885 professor of physics in Karlsruhe, then starting in 1889 at Bonn. 1887/88 exploration of the electromagnetic waves, now the basis for all radio communication, and exploration of the photoelectric effect, the basis of solar techniques. Numerous highranking distinctions. H. HERTZ: The case history is presented in detail based on numerous literal quotations from personal letters and the diary. After a few banal affections involving the teeth and toes the systemic disease became manifest in summer 1892 with a refractory cold which remained the focus of treatment until death. Granulation tissue in the nose that was excised several times: no tuberculosis, no carcinoma. Otitis with purulent mastoiditis, in October 1892 mastoidectomy, persistent purulence. Early in 1893 diagnosis of nephritis. Extraction of a superior tooth, punturing of the maxillary sinus, then twice radical opening of the maxillary sinus. Painful ankylosis and paralyses

  9. Amphipathic variable region heavy chain peptides derived from monoclonal human Wegener's anti-PR3 antibodies stimulate lymphocytes from patients with Wegener's granulomatosis and microscopic polyangiitis

    Science.gov (United States)

    Peen, E; Malone, C; Myers, C; Williams, R C; Peck, A B; Csernok, E; Gross, W L; Staud, R

    2001-01-01

    Amphipathic variable-region heavy chain 11-mer peptides from monoclonal human IgM antiproteinase-3 antibodies were studied for peripheral blood lymphocyte stimulation in 21 patients with Wegener's granulomatosis (WG) or microscopic polyangiitis (MPA), connective tissue disease controls and normal control subjects. Positive T-cell activation was observed in most experiments with WG patients' lymphocytes using amphipathic VH-region peptides from four different human monoclonal anti-PR3 antibodies. Control peptides of the same length but without amphipathic characteristics along with other amphipathic peptides not derived from monoclonal anti-PR3 sequence were employed as controls. No significant lymphocyte stimulation was observed with normal controls, but positive stimulation with amphipathic VH peptides was also recorded in other connective tissue disease controls mainly patients with rheumatoid arthritis. Amphipathic peptides not derived from anti-PR3 sequence did not stimulate WG lymphocytes. Our findings indicate that lymphocyte reactivity as an element of cell-mediated immunity may be activated by amphipathic VH-region amino acid sequences of autoantibodies which are themselves associated with diseases such as WG. PMID:11529926

  10. Airway Surgery in Tracheostomised Patients with Wegener Granulomatosis Leading to Subglottic Stenosis.

    Science.gov (United States)

    Altun, Demet; Sivrikoz, Nükhet; Çamcı, Emre

    2015-10-01

    Wegener granulomatosis (WG) is a multisystemic disorder characterised by granulomatous inflammation of the respiratory system. The growing of proliferative tissue towards the larynx and trachea may cause airway obstruction on account of subglottic stenosis. In this situation, the surgical goal is to eliminate the airway obstruction by providing natural airway anatomy. While mild lesions do not require surgical intervention, in fixed lesions, surgical intervention is required, such as tracheostomy, laser resection and dilatation. In tracheostomised patients, granuloma formation surrounding the tracheostomy cannula may occur in the trachea. Inflammation and newly formed granulation tissue result in severe stenosis in the airways. During surgical treatment of such patients, airway management is important. In this case report, we will discuss gas exchange and airway management with jet ventilation (JV) during excision of the granulation tissue with endolaryngeal laser surgery, leading to subglottic stenosis in tracheostomised patients in WG.

  11. Limited-Form Wegener Granulomatosis Case: Anaesthetic Approach and Literature Review.

    Science.gov (United States)

    Sarıtaş, Tuba Berra; Şahin, Osman; Borazan, Hale; Otelcioğlu, Şeref

    2014-12-01

    Wegener granulomatosis (WG) is a kind of vasculitis that affects small and medium-sized arteries. Necrotizing granulomatous vasculitis of the upper and lower respiratory tracts and necrotizing glomerulonephritis of the kidneys are present. WG affects mainly Caucasian individuals between 15-75 years old, with a mean age of onset of 41 years. It affects both males and females equally. Kidney involvement is not present in the limited form of WG. Peripheral nerve blocks are good alternatives when general anaesthesia is risky. Popliteal block is blockade of the sciatic nerve at the popliteal region. Popliteal block is a kind of peripheral block for surgeries below the knee level. In this article, we report on the anaesthesia management of a 61-year-old limited-form WG patient for whom general anaesthesia was risky because of lung involvement.

  12. [C-ANCA positive necrotising scleritis and multiple sclerosis compatible with ocular Wegener: treatment with rituximab].

    Science.gov (United States)

    Aldasoro-Cáceres, V; Aldasoro-Cáceres, I; Pérez-Moreiras, J V; Murié-Fernández, M; Ibáñez-Bosch, R

    2014-01-01

    A patient diagnosed with necrotizing scleritis, c-ANCA+ an orbital pseudotumour, and possible multiple sclerosis in 2003 was treated with oral cyclophosphamide and steroids with partial response. Between 2005-2010 she suffered self-limited episodes. In 2010 a first scleral transplant was performed with poor outcome. She was treated with rituximab, and a second graft was performed with good results. At 12 months there was no change in magnetic resonance and the second graft healed. Wegener's disease with limited involvement of the orbit and/or the eye is a rare condition. The histopathology, blood analysis, symptoms and good response to treatment are the key to its diagnosis. Copyright © 2011 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

  13. Detailed analysis of graft techniques for nasal reconstruction following Wegener granulomatosis.

    Science.gov (United States)

    Sepehr, Ali; Alexander, Ashlin J; Chauhan, Nitin; Gantous, Andres

    2011-12-01

    Saddle nose deformity secondary to Wegener granulomatosis (WG) presents a significant challenge for the reconstructive surgeon. Various grafting options have been proposed, but achieving good outcomes can be difficult. We conducted a retrospective analysis of 10 patients with WG who underwent reconstruction of saddle nose deformities by the senior author (A.G.) between 2005 and 2009. All patients were reconstructed using costal cartilage grafts. Primary surgery was functionally and cosmetically successful in 8 of 10 patients. Two patients experienced complications (graft resorption and columellar necrosis) requiring revision surgery; subsequently, they achieved good outcomes, with no further complications. There were no complications at the costal cartilage donor site. At the conclusion of the study, all patients were satisfied with their reconstructions. With a multidisciplinary team approach to pre- and postoperative patient management and careful surgical technique, reliable and excellent functional and cosmetic outcomes can be achieved with costal cartilage grafts.

  14. Current and future prospects in the management of granulomatosis with polyangiitis (Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    Tarzi RM

    2014-04-01

    Full Text Available Ruth M Tarzi, Charles D PuseyRenal and Vascular Inflammation Section, Department of Medicine, Imperial College, London, UKAbstract: Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis is a multisystem autoimmune condition associated with anti-neutrophil cytoplasm antibodies. Management of GPA can be complex, owing to the sometimes fulminant and multisystem nature of the presentation, the age demographics of the affected population, and a significant incidence of disease relapse. In this paper, we discuss how some of the challenges in the management of GPA have been and continue to be addressed including: reducing the toxicity of induction therapy; developing biomarkers to determine who can safely stop maintenance immunosuppression; improving the efficacy of maintenance therapy for relapsing patients; managing localized disease; and management of disease and treatment-associated comorbidity. Consideration is also given to emerging therapeutics in the treatment of GPA.Keywords: anti-neutrophil cytoplasm antibody, vasculitis, immunosuppression, biologics

  15. Wegener's Granulomatosis: A Model of Auto-antibodies in Mucosal Autoimmunity

    Science.gov (United States)

    Kelley, James M.; Edberg, Jeffrey C.; Kimberly, Robert P.

    2009-01-01

    Wegener's granulomatosis (WG) is an autoimmune condition marked by vasculitis of small and medium sized vessels particularly affecting the upper respiratory tract and kidneys. There is a strong mucosal component similar to other autoimmune conditions such as systemic lupus erythematosus and Behçet's disease. While the pathogenesis of WG is not completely known, auto-antibodies such as IgG ANCAs have been implicated in endovascular damage and modulation of neutrophil / monocyte responses by Fc receptor (FcR) signaling. Due to the substantial mucosal involvement in WG (oral, nasal, and upper respiratory tract involvement), it is probable that IgA antibodies (perhaps IgA ANCAs) play a role in disease. Given discrepancies in associating ANCA levels with disease activity, future work should determine if IgA ANCAs are present in WG patients and examine the biology underlying the ANCAs' signaling partners - the FcRs. PMID:19482554

  16. Pyoderma gangrenosum and Wegener granulomatosis-like syndrome induced by cocaine.

    Science.gov (United States)

    Jiménez-Gallo, D; Albarrán-Planelles, C; Linares-Barrios, M; Rodríguez-Hernández, C; Martínez-Rodríguez, A; García-Moreno, E; Bravo-Monge, R

    2013-12-01

    Cocaine abuse is associated with various skin and rheumatological diseases that mimic primary autoimmune diseases, including retiform purpura with involvement of the ears, cocaine-induced midline destructive lesions (CIMDL), and eruptive pyoderma gangrenosum (PG). Previous reports have suggested the use of perinuclear antineutrophil cytoplasmic antibodies (pANCA) with specificity against human neutrophil elastase (HNE) to differentiate these cocaine-induced diseases from primary autoimmune diseases. We describe a case of a 54-year-old woman with a history of cocaine abuse, who had PG lesions on her legs with accompanying CIMDL and lung lesions similar to those seen in Wegener granulomatosis. Detection of HNE-positive pANCA, and improvement or clinical recurrence after cessation or consumption of cocaine, respectively, were key to differentiating this presentation from primary autoimmune disease. © 2013 British Association of Dermatologists.

  17. [Tracheal resection for post-intubation subglottic stenosis in a patient with granulomatosis with polyangiitis (Wegener)].

    Science.gov (United States)

    Stoica, Radu; Negru, Irina; Matache, Radu; MirunaTodor

    2014-01-01

    Granulomatosis with polyangiitis (GPA or Wegener) is a systemic autoimmune disease with inflammation of small- and medium-size vessels. It can affect practically any organ or system, but renal, respiratory andjoint systems are most frequently damaged. Positive pANCA antibodies can raise the suspicion of diagnosis. Subglottic stenosis is relatively frequent, in a quarter of patients, especially in the third decade women. The case presented is of an 80-year-old woman, recently diagnosed with pulmonary, renal and systemic manifestations of GPA and with a subglottic stenosis rapidly evolving towards endotracheal intubation, tracheostomy with mechanical ventilation and renal failure. Further evolution has been favorable under corticoid therapy. After weaning from the mechanical ventilation and30 days after the suppression of the tracheostomy, the patient developed a tracheal stenosis with mixed etiology, secondary to vasculitis and prolonged intubation with tracheostomy. Tracheal resection with termino-terminal anastomosis was performed in emergency with simple post-operative evolution and without late complications.

  18. Meningeal involvement in Wegener granulomatosis: case report and review of the literature.

    Science.gov (United States)

    Soriano, A; Lo Vullo, M; Casale, M; Quattrocchi, C C; Afeltra, A

    2012-01-01

    Wegener Granulomatosis (WG) is a multisystem autoimmune disorder characterized by necrotizing granulomatous vasculitis that most commonly involves the upper respiratory tract, lungs, and kidneys. The involvement of the central nervous system (CNS) is infrequent and can cause stroke, cranial nerve abnormalities, cerebrovascular events, seizures, and meningeal involvement. Meningeal involvement is rare and may occur due to local vasculitis, directly spread from adjacent disease in the skull base, paranasal or orbital region. We describe the case of a 20-year-old Caucasian man who was diagnosed with sinonasal WG with frontal focal meningeal involvement. A literature review on diagnosis and treatment of meningeal involvement in course of WG was carried out. The importance of an early diagnosis and treatment of localized WG has been emphasized, in order to avoid the progression to a severe form of disease, especially in younger patients and in paucisymptomatic cases.

  19. ANCA-negative Wegener's granulomatosis with multiple lower cranial nerve palsies.

    Science.gov (United States)

    Kim, Sung-Hee; Park, Jin; Bae, Jung Ho; Cho, Min-Sun; Park, Kee Duk; Jeong, Jee Hyang

    2013-11-01

    Wegener's granulomatosis (WG) is a systemic vasculitis affecting small and medium-sized vessels with granulomatous formation. Though it is known for respiratory tract and kidney involvement, neurologic manifestation has been also reported. Herein we report a patient who suffered pansinusitis with multiple lower cranial nerve palsies but reached remission by immunosuppressant after the diagnosis of WG. A 54-yr-old female visited with headache, hearing difficulty, and progressive bulbar symptoms. She experienced endoscopic sinus surgeries due to refractory sinusitis. Neurologic examination revealed multiple lower cranial nerve palsies. Vasculitic markers showed no abnormality. Nasal biopsy revealed granulomatous inflammation and vasculitis involving small vessels. Given cyclophosphamide and prednisolone, her symptoms were prominently improved. WG should be considered in the patient with multiple cranial nerve palsies, especially those with paranasal sinus disease. Because WG can be lethal if delayed in treatment, prompt immunosuppressant is warranted after the diagnostic tissue biopsy.

  20. Wegener's granulomatosis and pyoderma gangrenosum--rare causes of facial ulcerations.

    Science.gov (United States)

    Kędzierska, Karolina; Sindrewicz, Krzysztof; Smektała, Tomasz; Wiśniewska, Magda; Masiuk, Marek; Staniszewska, Ewelina; Sporniak-Tutak, Katarzyna; Gołembiewska, Edyta; Ciechanowski, Kazimierz

    2016-03-16

    Pyoderma gangrenosum (PG) is caused by immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all PG patients also suffer from autoimmunological diseases, one of which is Wegener granulomatosis (WG). The purpose of this article was to compare cases of patients with WG and PG in terms of their clinical course, histopathology, and applied treatment. In both, histopathological features are not fully distinct. Data from microbiological and immunological evaluation and clinical presentation are required to establish the diagnosis. We also present the case of a patient with WG and deep facial skin lesions not responding to standard treatment. Systematic review of the literature in PubMed using the search terms "Wegener granulomatosis AND Pyoderma gangrenosum" and case report. The finding of 22 reports in the literature (PubMed) suggests that it is a rare phenomenon. This study revealed a similar rate of comorbidity of WG and PG in both genders and an increased incidence of both diseases after the age of 50. Among skin lesions there was a dominance of ulceration, most often deep and painful, covering a large area with the presence of advanced necrosis and destruction of the surrounding tissue. The most common location proved to be the cervical-cephalic area. The most popular treatment included steroids with cyclophosphamide. The rarity of the coexistence of these two diseases results in a lack of effective therapy. In such cases sulfone derivatives are still effective and provide an alternative to standard immunosuppression methods. Hyperbaric therapy and plasmapheresis can also play an important complementary role.

  1. Assessment of the Item Selection and Weighting in the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis

    Science.gov (United States)

    MAHR, ALFRED D.; NEOGI, TUHINA; LAVALLEY, MICHAEL P.; DAVIS, JOHN C.; HOFFMAN, GARY S.; MCCUNE, W. JOSEPH; SPECKS, ULRICH; SPIERA, ROBERT F.; ST.CLAIR, E. WILLIAM; STONE, JOHN H.; MERKEL, PETER A.

    2013-01-01

    Objective To assess the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG) with respect to its selection and weighting of items. Methods This study used the BVAS/WG data from the Wegener's Granulomatosis Etanercept Trial. The scoring frequencies of the 34 predefined items and any “other” items added by clinicians were calculated. Using linear regression with generalized estimating equations in which the physician global assessment (PGA) of disease activity was the dependent variable, we computed weights for all predefined items. We also created variables for clinical manifestations frequently added as other items, and computed weights for these as well. We searched for the model that included the items and their generated weights yielding an activity score with the highest R2 to predict the PGA. Results We analyzed 2,044 BVAS/WG assessments from 180 patients; 734 assessments were scored during active disease. The highest R2 with the PGA was obtained by scoring WG activity based on the following items: the 25 predefined items rated on ≥5 visits, the 2 newly created fatigue and weight loss variables, the remaining minor other and major other items, and a variable that signified whether new or worse items were present at a specific visit. The weights assigned to the items ranged from 1 to 21. Compared with the original BVAS/WG, this modified score correlated significantly more strongly with the PGA. Conclusion This study suggests possibilities to enhance the item selection and weighting of the BVAS/WG. These changes may increase this instrument's ability to capture the continuum of disease activity in WG. PMID:18512722

  2. Granulomatosis de Wegener Semejando Cáncer Epidermoide de Nasofaringe y Metástasis Pulmonares.

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    Gustavo Adolfo Martín Small

    2011-01-01

    Full Text Available La granulomatosis de Wegener (GW es una enfermedad idiopática, con posible componente autoinmune, que aparece generalmente en la quinta década de vida, caracterizándose por lesiones granulomatosas necrotizantes y vasculitis en vías aéreas y riñón. Paciente femenino de 54 años, quien desde Noviembre del 2008, presenta rinorrea, prurito y eritema en borde nasal inferior izquierdo, recibe antibióticos sin mejoría de los síntomas. En las radiografías torácicas, se observan dos radiopacidades redondeadas, de 4 cm de diámetro, sugestivas de lesiones tumorales en ambos campos pulmonares. La biopsia reporta cáncer epidermoide de alto grado, sospechándose primario en nasofaringe. Es remitida, por deterioro de condiciones, al Servicio de Neumonología del Hospital Universitario de Caracas el 18/03/2009, presentando disnea, tos productiva, placas purpúricas dolorosas en manos y pies, hipoacusia, hiperpigmentación del paladar duro, leucoplaquias y lesiones costrosas en lengua, insuficiencia renal (creatinina en 6,11 mg/dL y trombocitopenia. En TAC de tórax, se evidencian tumores mayores de 5 cm de diámetro, algunos con bordes bien definidos y otros mal delimitados con broncograma aéreo. Diagnostico definitivo de GW por serología. La GW con su afectación sistémica puede simular otras entidades como neoplasias de cabeza y cuello con metástasis pulmonares. Cuando las manifestaciones sistémicas son floridas debe sospecharse GW como diagnóstico diferencial. Palabras claves: Wegener, Granulomatosis, Vasculitis, Cáncer epidermoide.

  3. Jean-Alfred Fournier - the founder of the European venereology and dermatology (on the one hundredth death anniversary

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    O. A. Kisteneva

    2014-01-01

    Full Text Available The article presents a life story of a great French dermatologist and venereologist, one of the founders of the theory of syphilis Jean-Alfred Fournier (1832-1914. It provides data on the published works by Jean-Alfred Fournier, some of which earned him a doctoral degree. It also provides data on Fournier’s election as a member of the French Academy of Medicine in 1879 as well as on the founding of the French Society of Dermatology and Syphiligraphy by Fournier and other French dermatologists in 1889. The article defines the contribution made by Fournier to the development of venereology and practical medicine in the second half of the 19th century and early 20th century.

  4. Contribuciones de la fenomenologia de Alfred Schutz para las pesquisas sobre el SIDA: consideraciones epistemológicas y metodologicas

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    Leandro Oltramari

    2005-01-01

    Full Text Available The present article aims at discussing the contributions of Alfred Schutz's phenomenology to the field of research on sexual behavior and vulnerability to HIV/AIDS. First, na investigation of the main studies on vulnerability of HIV/AIDS in Brazil was carried out, along with a discussion on the main movement of the epidemic. Then, the phenomenological theory is discussed within the field of the social sciences based on the contributions by Alfred Schutz. Finally, a discussion on the epistemological and methodological application of the phenomenology in the studies on sexual behavior and risk of infection by HIV/Aids is presented, using categories as epoché and intersubjectivity.

  5. Number 13 / Part I. Music. 11. Great Contemporary Pianists in Interpretative Dialogue: Alfred Brendel and Murray Perahia

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    Tudor Brînduşa

    2017-03-01

    Full Text Available The choice of valuable interpretative versions is highly important for both pianists on their way to performance and teachers in their complex activity of piano training. These become real models of esthetical thinking and artistic inspiration in the approach of a musical work. We shall use Sonata in D minor D 958 by Franz Schubert as an interpretative analysis model in the view of the pianists Alfred Brendel and Murray Perahia.

  6. Wegener's Granulomatosis

    Science.gov (United States)

    ... male predominance. Granulomatosis with Polyangiitis typically occurs in middle age, but is found in people of all ages. ... with Polyangiitis in the upper respiratory tract. What’s New in Granulomatosis with Polyangiitis? In the past few ...

  7. The prominent absence of Alfred Russel Wallace at the Darwin anniversaries in Germany in 1909, 1959 and 2009.

    Science.gov (United States)

    Hossfeld, Uwe; Olsson, Lennart

    2013-12-01

    It is well known that the contribution of Alfred Russell Wallace (1823-1913) to the development of the "Darwinian" principle of natural selection has often been neglected. Here we focus on how the three anniversaries to celebrate the origin of the Darwin-Wallace theory in Germany in 1909, in 1959 in the divided country, as well as in 2009, have represented Charles Robert Darwin's and Alfred Russell Wallace's contributions. We have analyzed books and proceedings volumes related to these anniversaries, and the main result is that Wallace was almost always ignored, or only mentioned in passing. In 1909, Ernst Haeckel gave a talk in Jena, later published under the title The worldview of Darwin and Lamarck (Das Weltbild von Darwin und Lamarck), but not as the Darwin-Wallace concept. Haeckel mentions Wallace only once. In two important proceedings volumes from the 1959 anniversaries, Wallace was ignored. The only fair treatment of Wallace is given in another book, a collection of documents edited by Gerhard Heberer, for which the author selected nine key documents and reprinted excerpts (1959). Three of them were articles by Wallace, including the Sarawak- and Ternate-papers of 1855 and 1858, respectively. An analysis of the dominant themes during the celebrations of 2009 shows that none of the six topics had much to do with Wallace and his work. Thus, the tendency to exclude Alfred Russell Wallace is an international phenomenon, and largely attributable to the "Darwin industry".

  8. Socialization, Language, and Scenic Understanding. Alfred Lorenzer's Contribution to a Psycho-societal Methodology

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    Henning Salling Olesen

    2012-09-01

    Full Text Available The article is a guided tour to Alfred LORENZER's proposal for an "in-depth hermeneutic" cultural analysis methodology which was launched in an environment with an almost complete split between social sciences and psychology/psychoanalysis. It presents the background in his materialist socialization theory, which combines a social reinterpretation of the core insights in classical psychoanalysis—the unconscious, the drives—with a theory of language acquisition. His methodology is based on a transformation of the "scenic understanding" from a clinical to a text interpretation, which seeks to understand collective unconscious meaning in text, and is presented with an illustration of the interpretation procedure from social research. Then follows a brief systematic account of key concepts and ideas—interaction forms, engrams, experience, symbolization, language game, utopian imagination—with an outlook to the social theory connections to the Frankfurt School. The practical interpretation procedure in a LORENZER-based psycho-societal research is briefly summarized, emphasizing the role of the researcher subjects in discovering socially unconscious meaning in social interaction. Finally an outlook to contemporary epistemological issues. LORENZER's approach to theorize and research the subject as a socially produced entity appears as a psycho-societal alternative to mainstream social constructivism. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1203229

  9. The ornithologist Alfred Russel Wallace and the controversy surrounding the dinosaurian origin of birds.

    Science.gov (United States)

    Ibrahim, Nizar; Kutschera, Ulrich

    2013-12-01

    Over many years of his life, the British naturalist Alfred Russel Wallace (1823-1913) explored the tropical forests of Malaysia, collecting numerous specimens, including hundreds of birds, many of them new to science. Subsequently, Wallace published a series of papers on systematic ornithology, and discovered a new species on top of a volcano on Ternate, where he wrote, in 1858, his famous essay on natural selection. Based on this hands-on experience, and an analysis of an Archaeopteryx fossil, Wallace suggested that birds may have descended from dinosaurian ancestors. Here, we describe the "dinosaur-bird hypothesis" that originated with the work of Thomas H. Huxley (1825-1895). We present the strong evidence linking theropod dinosaurs to birds, and briefly outline the long and ongoing controversy around this concept. Dinosaurs preserving plumage, nesting sites and trace fossils provide overwhelming evidence for the dinosaurian origin of birds. Based on these recent findings of paleontological research, we conclude that extant birds indeed descended, with some modifications, from small, Mesozoic theropod dinosaurs. In the light of Wallace's view of bird origins, we critically evaluate recent opposing views to this idea, including Ernst Mayr's (1904-2005) arguments against the "dinosaur-bird hypothesis", and document that this famous ornithologist was not correct in his assessment of this important aspect of vertebrate evolution.

  10. BREASTFEEDING EXPERIENCED BY COLLEGE STUDENTS: CONTRIBUTIONS OF NURSING IN LIGHT OF THE PHENOMENOLOGY OF ALFRED SCHUTZ

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    Karina Viana Ribeiro

    2011-09-01

    Full Text Available O estudo teve como objeto o aleitamento materno na prática cotidiana da estudante de nível superior. Objetivo: captar as experiências vivenciadas pela estudante com o aleitamento materno durante a realização do curso de graduação. Métodos: Trata-se de um estudo qualitativo com enfoque na Fenomenologia Sociológica de Alfred Schutz, utilizando-se a entrevista fenomenológica. Os sujeitos foram estudantes de graduação que vivenciaram ou vivenciavam a gestação e/ou amamentação durante o curso de graduação numa universidade pública no Estado do Rio de Janeiro. Resultados: Surgiram as seguintes categorias: 1. Amamentar implica dificuldades para estudar; 2. Amamentar requer lançar mão de estratégias para continuar estudando e amamentando; 3. Amamentar precisa de apoio. Conclusões: Assim, o estudo é relevante por possibilitar a compreensão acerca do fenômeno amamentar no cotidiano da estudante e, a partir dele, discutir leis de proteção a essa população. Descritores: aleitamento materno, pesquisa qualitativa, enfermagem.

  11. Alfred Russel Wallace and the destruction of island life: the Iguana tragedy.

    Science.gov (United States)

    Kutschera, Ulrich; Kleinhans, Simon

    2013-12-01

    The Galápagos Islands (Ecuador) are usually associated with the explorations and theoretical deductions of Charles Robert Darwin (1809-1882), but Alfred Russel Wallace (1823-1913) also investigated these islands and published several reports on the living world of this unique archipelago. In contrast to Darwin, Wallace described the destruction of natural ecosystems by humans and foresaw the resulting extinction of species. Here, we outline two case studies pertinent to Wallace's prediction. First, we summarize the behavior of the predator-naive marine iguanas (Amblyrhynchus cristatus) on the Galápagos Islands, which are threatened by feral dogs and cats imported by humans. We also describe the unique life cycle of the spiny-tailed iguana (Ctenosaura bakeri) from the island of Utila (Honduras), a rare species whose populations are declining because of habitat destructions. In contrast to these threatened, endemic island species, the Green iguana (Iguana iguana) is still widely distributed, although, as a result of de-forestation, in some areas of South America local populations have disappeared. We conclude that Wallace was correct in his prediction that, because of human activities, numerous species of animals and plants will be driven to extinction, notably on islands.

  12. Deciphering the evolution of birdwing butterflies 150 years after Alfred Russel Wallace

    Science.gov (United States)

    Condamine, Fabien L.; Toussaint, Emmanuel F. A.; Clamens, Anne-Laure; Genson, Gwenaelle; Sperling, Felix A. H.; Kergoat, Gael J.

    2015-01-01

    One hundred and fifty years after Alfred Wallace studied the geographical variation and species diversity of butterflies in the Indomalayan-Australasian Archipelago, the processes responsible for their biogeographical pattern remain equivocal. We analysed the macroevolutionary mechanisms accounting for the temporal and geographical diversification of the charismatic birdwing butterflies (Papilionidae), a major focus of Wallace’s pioneering work. Bayesian phylogenetics and dating analyses of the birdwings were conducted using mitochondrial and nuclear genes. The combination of maximum likelihood analyses to estimate biogeographical history and diversification rates reveals that diversity-dependence processes drove the radiation of birdwings, and that speciation was often associated with founder-events colonizing new islands, especially in Wallacea. Palaeo-environment diversification models also suggest that high extinction rates occurred during periods of elevated sea level and global warming. We demonstrated a pattern of spatio-temporal habitat dynamics that continuously created or erased habitats suitable for birdwing biodiversity. Since birdwings were extinction-prone during the Miocene (warmer temperatures and elevated sea levels), the cooling period after the mid-Miocene climatic optimum fostered birdwing diversification due to the release of extinction. This also suggests that current global changes may represent a serious conservation threat to this flagship group. PMID:26133078

  13. Alfred Smith (1822-1898, pioneiro do turismo ornitológico em Portugal

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    Nuno Oliveira

    2015-06-01

    Full Text Available Desde cedo Portugal foi um destino de turismo ornitológico (ecoturístico e Alfred Smith foi um dos primeiros, senão o primeiro, turista a vir a Portugal, em 1868, motivado pelo interesse pelas aves. O livro que publicou contém uma lista inédita de aves de Portugal, que só encontrámos porque o bibliotecário da Academia de Ciências de Nova York acrescentou ao título, na ficha bibliográfica “com uma capítulo sobre as aves de Portugal, e uma lista de 235 espécies cuidadosamente determinadas”. Hoje o turismo ornitológico e o ecoturismo já se estão a desenvolver a bom ritmo e as espécies de aves ibéricas (a par da paisagem, da flora e da restante fauna constituem um produto turístico em que se deve apostar e que valoriza, essencialmente, as regiões do interior.

  14. Alfred Russel Wallace's medical libertarianism: state medicine, human progress, and evolutionary purpose.

    Science.gov (United States)

    Flannery, Michael A

    2015-01-01

    Alfred Russel Wallace (1823-1913), naturalist and explorer of South America and the Malay Archipelago, secured his place in history by independently discovering the theory of natural selection. His letter outlining the theory was sent from Ternate in eastern Indonesia and received at Down House, according to Charles Darwin (1809-82), on June 18, 1858, prompting the now-famed evolutionist to rush his languishing manuscript to press. Wallace's contributions to evolutionary biology, biogeography, and anthropology are well known, but his medical views have received far less attention. Within the context of a strident populist antivaccination movement and an ominous elitist eugenics campaign, Wallace took his stand, which revealed itself in a libertarianism that defended traditional socialist constituencies (the working poor, the lumpenproletariat, and feminist reformers) against state-mandated medical interventions. Rather than viewing Wallace as a heterodox contrarian, this article argues that his positions were logical outgrowths of his medical libertarianism and evolutionary and social theories. © The Author 2013. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  15. Early East Asian art history in Vienna and its trajectories: Josef Strzygowski, Karl With, Alfred Salmony

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    Julia Orell

    2015-12-01

    Full Text Available In 1912 Josef Strzygowski founded the ‘Section for East Asian Art History’ at the University of Vienna, which attracted many students who would continue their careers in museums and at universities and thus established East Asian art history as an academic field. This paper examines these early art historical engagements with East Asian art: First, I discuss the role of East Asian art in Strzygowski’s agenda of broadening art history’s geographical scope beyond Europe and in his argument about the dominance of ‘Nordic’ artistic traditions in Europe and in Asia. Secondly, I introduce the work of two early students at the ‘Section for East Asian Art History’ in Vienna, Karl With and Alfred Salmony. Their respective approaches to East Asian art exemplify a range of methodological concerns of their time, from stylistic narratives, the concept of ars una, comparative frameworks, to ideas about cultural or national ‘purity’ in the arts, and an interest in cross-cultural adaption and transformation of motifs and symbolism.

  16. Tyranny as a Childlike Power. The Ubu Roi of Alfred Jarry

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    Duccio Chiapello

    2013-12-01

    Full Text Available In the eighties of the nineteenth century Ubu comes into the world. Thanks to Alfred Jarry, in around ten years this imaginary tyrant with unrestrained longings will rise to an outstanding position in the Parisian theatrical arena. Ubu, anyway, is not a mere culture phenomenon: he is also – better, he is first of all – the outcome of an unprecedented and primitive reflection on power. So Ubu, from the beginning, is the embodiment of the excess, the expression of tyranny as the childish power par excellence, driven by a bulimic imagination and dragged by overwhelming yearnings, always associated with the denial of any decorum and mediation. Ubu is, to a certain extent, one of the most prophetic and accurate anticipations of that imbalance between the autocrat’s longings and the endurance degree of the environment around him: a political pathology which will be the eminent and dramatic feature of the terrible catastrophes of the 20th century. Jarry’s work is even more significant when, in the last of its plays, describes an institutional system protected by a brittle glass bell, unbreakable only by those who hesitate to strike it, and an administrative apparatus so much subject to arbitrary power that it seems built «by the tyrant himself».

  17. Conceptual design of a bayonet-tube steam generator for the ALFRED lead-cooled reactor

    International Nuclear Information System (INIS)

    Damiani, Lorenzo; Montecucco, Massimo; Pini Prato, Alessandro

    2013-01-01

    Highlights: • Conceptual design of a bayonet-tube steam generator for a lead-cooled reactor demonstrator. • Steady-state simulations effected through RELAP 5. • Performance evaluation of the steam generator for different configurations of the bayonet tubes. - Abstract: The present paper is centred on the design of a bayonet tube steam generator, fundamental part of an innovative lead-cooled fast nuclear reactor (LFR). The construction of the LFR is the main objective of the European project named LEADER, of which Ansaldo Nucleare is an important member. The steam generator described in this paper is expected to be installed in a 300 MW thermal power demonstrator plant, named ALFRED. The investigations carried out in this work through the RELAP 5 code have first faced the sizing of the single bayonet tube and then the design of the whole heat exchanger. The configurations of the four coaxial tubes composing the single bayonet, the length of the bayonets and the materials employed have been investigated; the final heat exchanger configuration provides 510 bayonet tubes of 6 m active length with a thermal insulation between the inner descending tube and the rising annulus, assured by a special extremely insulating paint. The whole steam generator has shown its capability to reach the required exchanged power of 37.5 MW th , providing as output dry superheated steam at the desired temperature of 450 °C

  18. Psychoanalysis, Socialization and Society—The Psychoanalytical Thought and Interpretation of Alfred Lorenzer

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    Thomas Leithäuser

    2012-09-01

    Full Text Available Alfred LORENZER belongs to those few psychoanalysts, who did understand psychoanalysis not only in clinical therapy, clinical thinking and research but also as a social science. In the perspective of LORENZER the individual fundamentally could not be taken out of his social contexts. The therapeutic setting of psychoanalysis insofar is an artificial undertaking, a psychological experiment of a special kind. LORENZER did understand society not only as an environment outside of the individual, how it is studied through most of the psychological paradigms. In the sense of LORENZER society penetrates and mediates the deep individual structures. He describes this process as a socialization of the individual. In my following essay I discuss the perspective of LORENZER's research in the fields of mother-child-relationship, of the child's learning of language, of work-relationships, and of religious and ideological attitudes. My research interest is directed on the complex mediation of familial and social interaction forms. The center of the analyses is the concept of the unconsciousness, which LORENZER has developed in a close relation to Sigmund FREUD. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1203176

  19. Mastoidite e paralisia facial como manifestações iniciais de Granulomatose de Wegener Mastoiditis and facial paralysis as initial manifestations of Wegener's Granulomatosis

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    André Souza de Albuquerque Maranhão

    2012-04-01

    Full Text Available A Granulomatose de Wegener (GW é caracterizada por granulomas necrotizantes e vasculite. Sem tratamento a doença tem prognóstico pobre com índice de mortalidade de 90% em 2 anos. Diversos autores citam as manifestações otológicas no curso da GW, entretanto não é especificado em que momento da doença elas apareceram, isto é, se como manifestação inicial ou subsequente a outros achados. Objetivo: Descrever três casos confirmados de GW que apresentaram inicialmente mastoidite e evoluíram com paralisia facial periférica (PFP. Material e Método: Estudo de série de casos. Pacientes diagnosticados com GW que apresentaram inicialmente manifestações otológicas são descritos. Resultados: Os três casos descritos abriram o quadro com otalgia, otorreia e hipoacusia unilateral, associada a paralisia facial periférica ipsilateral. Tiveram resposta inadequada aos tratamentos instituídos o que motivou uma investigação de outras doenças associadas. Nessas circunstâncias, detectaram-se títulos positivos de ANCA-C em todos pacientes, confirmando-se o diagnóstico de GW, após período variável de investigação. Institui-se o tratamento para GW observando-se melhora do quadro clínico, regressão da PFP e melhora parcial dos limiares auditivos. Conclusão: Complicações de otites médias agudas (mastoidite e PFP refratárias as terapêuticas habituais impõem a investigação de doenças associadas e a GW deverá ser pesquisada para que se possa fazer o diagnóstico o mais precocemente possível, alterando desta forma o prognóstico destes pacientes.Wegener's Granulomatosis (WG is characterized by necrotizing granulomas and vasculitis. If left untreated, the prognosis is poor - a 90% mortality rate within 2 years. Several authors have described the otologic manifestations of WG; these authors, however, have not mentioned the stage of the disease in which these findings present - whether as initial manifestations or subsequent to

  20. The Wegener-Bergeron-Findeisen process – Its discovery and vital importance for weather and climate

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    Trude Storelvmo

    2015-04-01

    Full Text Available The Wegener-Bergeron-Findeisen process refers to the rapid growth of ice crystals at the expense of surrounding cloud droplets, which frequently occurs in atmospheric mixed-phase clouds. The process is a result of the difference in saturation vapor pressures with respect to liquid and ice, and may in some circumstances lead to abrupt and complete cloud glaciation at temperatures between −40 °C and 0 °C in the Earth's atmosphere. The process is named after three eminent scientists who were active in the first half of the 20th century, among them being German meteorologist Walter Findeisen (1909–1945. In his classical paper published in 1938, Findeisen described the contemporary understanding of the Wegener-Bergeron-Findeisen process and other key cloud microphysical processes. Here, we compare the understanding of the aforementioned processes at the time with that of the present, and find that they are remarkably similar. We also discuss how the Wegener-Bergeron-Findeisen process is implemented in state-of-the-art numerical models of the atmosphere, and highlight its importance for both weather and climate.

  1. Chronic thrombotic microangiopathy secondary to chemotherapy for urothelial carcinoma in a patient with a history of Wegener granulomatosis.

    Science.gov (United States)

    Thomas, Jacob G; Sethi, Sanjeev; Norby, Suzanne M

    2011-05-01

    We present the case of a 62-year-old man with a history of Wegener granulomatosis who developed chronic thrombotic microangiopathy attributed to gemcitabine chemotherapy. Wegener granulomatosis had been diagnosed 15 years earlier, and the patient was treated using cyclophosphamide and prednisone, then maintained on mycophenolate mofetil and prednisone. Four years previously, he had been treated with mitomycin C for urothelial carcinoma and at the time of presentation had developed significant anemia and thrombocytopenia after a course of gemcitabine and carboplatin due to metastasis of the carcinoma. He was managed using red blood cell and platelet transfusions but then developed acute kidney injury, along with progressive dyspnea and pulmonary infiltrates. Imaging studies showed bilateral ureteral obstruction requiring placement of nephrostomy tubes. Because of concern about a flare of Wegener granulomatosis after withdrawing maintenance immunosuppression in the context of the malignancy, a kidney biopsy was performed that showed chronic thrombotic microangiopathy, likely secondary to gemcitabine chemotherapy. Clinical, laboratory, and pathologic findings of this case are discussed to illustrate the natural history of thrombotic microangiopathy associated with gemcitabine chemotherapy. Copyright © 2011 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  2. The core design of ALFRED, a demonstrator for the European lead-cooled reactors

    International Nuclear Information System (INIS)

    Grasso, G.; Petrovich, C.; Mattioli, D.; Artioli, C.; Sciora, P.; Gugiu, D.; Bandini, G.; Bubelis, E.; Mikityuk, K.

    2014-01-01

    Highlights: • The design for the lead fast reactor is conceived in a comprehensive approach. • Neutronic, thermal-hydraulic, and transient analyses show promising results. • The system is designed to withstand even design extension conditions accidents. • Activation products in lead, including polonium, are evaluated. - Abstract: The European Union has recently co-funded the LEADER (Lead-cooled European Advanced DEmonstration Reactor) project, in the frame of which the preliminary designs of an industrial size lead-cooled reactor (1500 MW th ) and of its demonstrator reactor (300 MW th ) were developed. The latter is called ALFRED (Advanced Lead-cooled Fast Reactor European Demonstrator) and its core, as designed and characterized in the project, is presented here. The core parameters have been fixed in a comprehensive approach taking into account the main technological constraints and goals of the system from the very beginning: the limiting temperature of the clad and of the fuel, the Pu enrichment, the achievement of a burn-up of 100 GWd/t, the respect of the integrity of the system even in design extension conditions (DEC). After the general core design has been fixed, it has been characterized from the neutronic point of view by two independent codes (MCNPX and ERANOS), whose results are compared. The power deposition and the reactivity coefficient calculations have been used respectively as input for the thermal-hydraulic analysis (TRACE, CFD and ANTEO codes) and for some preliminary transient calculations (RELAP, CATHARE and SIM-LFR codes). The results of the lead activation analysis are also presented (FISPACT code). Some issues of the core design are to be reviewed and improved, uncertainties are still to be evaluated, but the verifications performed so far confirm the promising safety features of the lead-cooled fast reactors

  3. The core design of ALFRED, a demonstrator for the European lead-cooled reactors

    Energy Technology Data Exchange (ETDEWEB)

    Grasso, G., E-mail: giacomo.grasso@enea.it [ENEA (Italian National Agency for New Technologies, Energy and Sustainable Economic Development), via Martiri di Monte Sole, 4, 40129 Bologna (Italy); Petrovich, C., E-mail: carlo.petrovich@enea.it [ENEA (Italian National Agency for New Technologies, Energy and Sustainable Economic Development), via Martiri di Monte Sole, 4, 40129 Bologna (Italy); Mattioli, D., E-mail: davide.mattioli@enea.it [ENEA (Italian National Agency for New Technologies, Energy and Sustainable Economic Development), via Martiri di Monte Sole, 4, 40129 Bologna (Italy); Artioli, C., E-mail: carlo.artioli@enea.it [ENEA (Italian National Agency for New Technologies, Energy and Sustainable Economic Development), via Martiri di Monte Sole, 4, 40129 Bologna (Italy); Sciora, P., E-mail: pierre.sciora@cea.fr [CEA (Alternative Energies and Atomic Energy Commission), DEN, DER, 13108 St Paul lez Durance (France); Gugiu, D., E-mail: daniela.gugiu@nuclear.ro [RATEN-ICN (Institute for Nuclear Research), Cod 115400 Mioveni, Str. Campului, 1, Jud. Arges (Romania); Bandini, G., E-mail: giacomino.bandini@enea.it [ENEA (Italian National Agency for New Technologies, Energy and Sustainable Economic Development), via Martiri di Monte Sole, 4, 40129 Bologna (Italy); Bubelis, E., E-mail: evaldas.bubelis@kit.edu [KIT (Karlsruhe Institute of Technology), Institute for Neutron Physics and Reactor Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Mikityuk, K., E-mail: konstantin.mikityuk@psi.ch [PSI (Paul Scherrer Institute), OHSA/D11, 5232 Villigen PSI (Switzerland)

    2014-10-15

    Highlights: • The design for the lead fast reactor is conceived in a comprehensive approach. • Neutronic, thermal-hydraulic, and transient analyses show promising results. • The system is designed to withstand even design extension conditions accidents. • Activation products in lead, including polonium, are evaluated. - Abstract: The European Union has recently co-funded the LEADER (Lead-cooled European Advanced DEmonstration Reactor) project, in the frame of which the preliminary designs of an industrial size lead-cooled reactor (1500 MW{sub th}) and of its demonstrator reactor (300 MW{sub th}) were developed. The latter is called ALFRED (Advanced Lead-cooled Fast Reactor European Demonstrator) and its core, as designed and characterized in the project, is presented here. The core parameters have been fixed in a comprehensive approach taking into account the main technological constraints and goals of the system from the very beginning: the limiting temperature of the clad and of the fuel, the Pu enrichment, the achievement of a burn-up of 100 GWd/t, the respect of the integrity of the system even in design extension conditions (DEC). After the general core design has been fixed, it has been characterized from the neutronic point of view by two independent codes (MCNPX and ERANOS), whose results are compared. The power deposition and the reactivity coefficient calculations have been used respectively as input for the thermal-hydraulic analysis (TRACE, CFD and ANTEO codes) and for some preliminary transient calculations (RELAP, CATHARE and SIM-LFR codes). The results of the lead activation analysis are also presented (FISPACT code). Some issues of the core design are to be reviewed and improved, uncertainties are still to be evaluated, but the verifications performed so far confirm the promising safety features of the lead-cooled fast reactors.

  4. Granulomatose de Wegener – Envolvimento otológico, nasal, laringotraqueal e pulmonar

    Directory of Open Access Journals (Sweden)

    Sandra Figueiredo

    2009-09-01

    Full Text Available Resumo: A granulomatose de Wegener é uma vasculite sistémica rara e idiopática caracterizada pelo atingimento dos pequenos vasos. A doença atinge, preferencial-mente, as vias aérea superior e inferior e os rins, levando à formação de granulomas e necrose destes órgãos. As manifestações clínicas e o envolvimento orgânico variam largamente. O diagnóstico e tratamento precoce podem levar à recuperação total. No entanto, o atraso no diagnóstico pode ser fatal. Os autores apresentam o caso de uma doente de 33 anos com uma forma de apresentação grave e rara da doença, mas com uma evolução favorável após diagnóstico e tratamento adequado.Rev Port Pneumol 2009; XV (5: 929-935 Abstract: Wegener granulomatosis is a rare systemic idiopathic disease characterized by involvement of small vessels – medium and small arteries, venules, arterioles and ocasionally large arteries. This disease has predilection for the upper and lower respiratory tract and the kidney, with granulomatous inflamation and necrosis. Clinical manifestations and organ involvement of the disease vary widely. Early diagnosis and treatment may lead to a full recovery. Without treatment, Wegener’s granulomatosis can be fatal. The authors present a case of a 33 year-old female, with severe disease, but with good outcome, after adequate diagnosis and treatment.Rev Port Pneumol 2009; XV (5: 929-935 Palavras-chave: Granulomatose de Wegener, forma limitada grave, Key-words: Wegener´s granulomatosis, severe limited form

  5. Nuclear Planetology: Constraining the Driving Force in Wegener's Continental Drift Theory

    Science.gov (United States)

    Roller, G.

    2015-12-01

    Nuclear planetology [1] is a new research field, which aims at deciphering the nuclear physics processes responsible for the evolution of ultra-substellar objects and the driving force in Wegener's continental drift theory by means of Re-Os nuclear geochronometry [2]. Terrestrial Re/Os ratios observed within diamond sulphide inclusions [3], compatible with lunar r-process production ratios of Th/U≈1≈Au/Ir [4], drop from ≈0.8 to 0.2-0.05 for nucleogeochronometric ages between 2.3 Ga and 1.4 Ga [5]. It has therefore been argued [5,6] that the Re/Os fractionation is related to a change in oxygen fugacity due to the physics/chemistry of Earth's core after a possibly Fermi-pressure controlled core collapse [4]. Here, Pd/Ru, Pd/Pt, Pd/Ir, Pd/Os, Ru/Ir, Ru/Os, Pt/Ir or Pt/Os ratios from 24 published H chondrite components [7] are connected to their respective nucleogeochronometric ages to constrain an extended fossil fractionation record over 800 Ma. The following ranges are obtained: 0.06-1.04 (Pd/Ru), 0.06-0.79 (Pd/Pt), 0.06-1.76 (Pd/Os), 0.07-1.94 (Pd/Ir), 1.08-1.99 (Ru/Ir), 0.83-2.41 (Pt/Os), 0.82-2.64 (Pt/Ir). Comparing the Re/Os fractionation pattern of the diamond sulphide inclusions with these results and considering that Re is readily oxidized even at ultra-low oxygen fugacity, it may be concluded that (i) extremely reducing conditions within Earth's core basically preserve any unfractionated r-process element ratio until today; and (ii) nuclear/quantum physics processes leading to the observed ratios and fractionation pattern are ultimately the driving force in Wegener's continental drift theory. [1] Roller (2015), Abstract T34B-0407, AGU Spring Meeting. [2] Roller (2015), Geophys. Res. Abstr. 17, EGU2015-17. [3] Smit et al. (2010), GCA 74, 3292. [4] Roller (2015), Abstract #5041, 78th Ann. Met. Soc. Meeting. [5] Roller (2015), Geophys. Res. Abstr. 17, EGU2015-2399. [6] Roller (2015), Abstract PG34A-0283, AGU Spring Meeting. [7] Horan et al. (2009), GCA 73

  6. Qualitative Research in Organizational Studies: Phenomenological Contributions of Alfred Schütz Pesquisa Qualitativa nos Estudos Organizacionais: Contribuições Fenomenológicas de Alfred Schütz

    Directory of Open Access Journals (Sweden)

    Fernando Gomes de Paiva Júnior

    2009-03-01

    Full Text Available Modern science is in crisis. Today, we live in a scientific paradigm transition motivated by differences and complexities. In the organizational field, qualitative research emerges as a methodological alternative to the researcher. It aids the contemporary understanding of the actor involved with the management phenomenon, as it reveals his/her impressions and feelings related to personal and professional lived experiences. The interpretative approach of Alfred Schütz's social phenomenology constitutes one of the variants of the phenomenological movement that makes knowledge of essences possible, and constitutes a type of "intelligible armor" of the organizational being's understanding, which has its structure and specific laws.

  7. Estenose subglótica como manifestação clínica da granulomatose de Wegener em adolescentes: relato de caso e revisão de literatura Subglottic stenosis as a clinical manifestation of Wegener's granulomatosis in adolescents: report of a case and review of literature

    Directory of Open Access Journals (Sweden)

    Márcia C. Machado

    2003-10-01

    Full Text Available A Granulomatose de Wegener é uma patologia caracterizada por vasculite sistêmica e inflamação granulomatosa necrotizante que compromete o trato respiratório alto, pulmões e rins, cujas manifestações iniciais, na maioria das vezes, ocorre em maiores de 20 anos de idade. As queixas clínicas otorrinolaringológicas estão, com freqüência, presentes nas fases iniciais da doença, sendo rinite, sinusopatia de repetição e epistaxe as mais comuns. A estenose subglógica parece estar correlacionada com a Granulomatose de Wegener em adolescentes. Relatamos o caso de uma paciente portadora de Granulomatose de Wegener cujo início dos sintomas foi na infância, tendo evoluído com estenose laríngea durante o curso da doença.Wegener's Granulomatosis is a well-characterized systemic vasculitis and necrotising granulomatous inflammation of the upper, lower respiratory tracts and the kidneys. The initial manifestations of the disease usually occur in patients over than twenty years old. The otolaryngologic symptoms like rhinorrhea, recurrent sinusitis and epistaxis are commonly present in early course of the disease. It seems that subglottic stenosis is correlated to Wegener's granumatosis in adolescents. We describe a case of a patient that developed subglottic stenosis associated with Wegener's granulomatosis in childhood during the course of the disease.

  8. The color of complexes and UV-vis spectroscopy as an analytical tool of Alfred Werner's group at the University of Zurich.

    Science.gov (United States)

    Fox, Thomas; Berke, Heinz

    2014-01-01

    Two PhD theses (Alexander Gordienko, 1912; Johannes Angerstein, 1914) and a dissertation in partial fulfillment of a PhD thesis (H. S. French, Zurich, 1914) are reviewed that deal with hitherto unpublished UV-vis spectroscopy work of coordination compounds in the group of Alfred Werner. The method of measurement of UV-vis spectra at Alfred Werner's time is described in detail. Examples of spectra of complexes are given, which were partly interpreted in terms of structure (cis ↔ trans configuration, counting number of bands for structural relationships, and shift of general spectral features by consecutive replacement of ligands). A more complete interpretation of spectra was hampered at Alfred Werner's time by the lack of a light absorption theory and a correct theory of electron excitation, and the lack of a ligand field theory for coordination compounds. The experimentally difficult data acquisitions and the difficult spectral interpretations might have been reasons why this method did not experience a breakthrough in Alfred Werner's group to play a more prominent role as an important analytical method. Nevertheless the application of UV-vis spectroscopy on coordination compounds was unique and novel, and witnesses Alfred Werner's great aptitude and keenness to always try and go beyond conventional practice.

  9. Wegener's granulomatosis: report of a case with rapidly progressive glomerulonephritis and diabetes mellitus.

    Science.gov (United States)

    Kakoi, H; Hiraide, F; Nishizawa, S; Inouye, T; Yoshizawa, N

    1986-01-01

    A patient with the classic form of Wegener's granulomatosis with severe dabetes mellitus and rapidly progressive glomerulonephritis is described. This 61-year-old male presented with epistaxis and nasal pain and obstruction. The nasal cavities were filled with crusts covering eroded mucosa. The diagnosis was made by biopsy of nasal and bronchial mucosa, and laboratory data. The epistaxis was stopped by 10 Gy irradiation over the nasal cavities. The patient had severe diabetes mellitus. His blood sugar was not controlled by diet and insulin injection. His general condition worsened rapidly as the growth of granuloma in the nose and lung. Accordingly, prednisolone therapy reinitiated to suppress the granuloma although it has a reverse effect on diabetes mellitus. Approximately one month after admission, he died of acute renal failure. Autopsy was carried out. Granulomatous lesions were noted in the nasal cavities, lungs and spleen. Many petechiae were found macroscopically over the cortex of the kidney. Hyalinization or sclerosis with crescent formation was found microscopically in estimated 85% of the glomeruli. Immunohistologic analysis of the renal tissue demonstrated an irregular linear pattern deposition of IgG, IgA and C3 and a granular pattern deposition of IgM and C1q.

  10. [Severe toe gangrene as an early manifestation of Wegener granulomatosis in a young patient].

    Science.gov (United States)

    Binder, C; Schattenkirchner, M; Krüger, K

    1998-08-01

    Gangrene of digits is a very rare manifestation of Wegener's granulomatosis (WG). We report a case of a 29-year-old woman with nonspecific symptoms like fever, weight loss, arthralgia, arthritis and high systemic inflammatory signs. On the grounds of a presumed infection the patient was treated with antibiotics which showed no effect. Within short she complained of pain and paresthesia of the right foot with a rapid lividity. Angiography demonstrated multiples stenoses and multisegmental occlusions of the lower leg arteries. Together with renal and pulmonal symptoms a WG was suspected, the diagnosis being confirmed by kidney biopsy and positive cANCAs. A few months after starting a combined therapy with cyclophosphamide and corticosteroids the patient showed a partial remission with a residual toe gangrene. Comparing the five worldwide reported cases with digital gangrene and our presentation there is a concordance of all in the occurrence of an extremely high disease activity together with a glomerulonephritis. The findings of p-ANCAs in our patient and positive Hbs antigen in another case of WG with digital gangrene suggests a relation to panarteriitis nodosa, where gangren is more common.

  11. Otomastoiditis como manifestación clínica inicial de granulomatosis de Wegener

    Directory of Open Access Journals (Sweden)

    Jorge De All

    2011-02-01

    Full Text Available La granulomatosis de Wegener (GW forma parte del grupo de vasculitis primarias, de vasos pequeños y medianos, asociadas a anticuerpos anticitoplasma de neutrófilos (ANCA. Esta enfermedad puede afectar cualquier órgano, especialmente vías aéreas superiores, inferiores y el riñón. Muy raramente la primera y única manifestación clínica de GW generalizada es la otomastoiditis. Presentamos el caso de un paciente que inició su enfermedad con una inflamación del oído medio, sin respuesta al tratamiento habitual. Posteriormente agregó compromiso nasal, pulmonar y renal. La determinación de anticuerpos anticitoplasma de neutrófilos y la biopsia transbronquial confirmaron el diagnóstico de GW. Comunicamos este caso para referir que la otomastoiditis del adulto, refractaria al tratamiento habitual, puede raramente ser la primera y única manifestación clínica de la GW.

  12. [A case of Wegener granulomatosis after treatment for non-tuberculous mycobacteriosis].

    Science.gov (United States)

    Fukusumi, Munehisa; Miyazaki, Kenji; Shibata, Masahiko; Aizawa, Toyoaki; Sakai, Toshihiko; Takemura, Tamiko; Tojima, Hirokazu

    2011-01-01

    A 67-year-old woman with a history of non-tuberculous mycobacteriosis due to Mycobacterium avium in 2002 and 2006 was admitted because of low-grade fever and cavitary lesions in both lungs on chest computed tomography (CT). Bronchial brushing cytology by bronchoscopy did not yield mycobacterium. Her serum antineutrophil cytoplasmic antibodies (MPO-ANCA) level was elevated and PR3 ANCA was negative. A surgical lung biopsy revealed basophilic necrosis with cavitary lesions and necrotizing vasculitis compatible with Wegener granulomatosis (WG). In the resected specimen, several hyalinizing nodules with caseous necrosis, probably associated with previous mycobacterium infection, were also seen. Because her disease was limited to the lungs, we successfully treated her with corticosteroids and methotrexate. WG is considered to be a type of ANCA-associated vasculitis, and microbial infections have been associated with initiation and relapse of WG. This case clearly demonstrated that lesions of WG occurred after mycobacterial infection in the lung. We believe that this case was ANCA production in association with bacterial infection.

  13. Association study with Wegener granulomatosis of the human phospholipase Cγ2 gene

    Directory of Open Access Journals (Sweden)

    Csernok Elena

    2005-02-01

    Full Text Available Abstract Background Wegener Granulomatosis (WG is a multifactorial disease of yet unknown aetiology characterized by granulomata of the respiratory tract and systemic necrotizing vasculitis. Analyses of candidate genes revealed several associations, e.g. with α(1-antitrypsin, proteinase 3 and with the HLA-DPB1 locus. A mutation in the abnormal limb mutant 5 (ALI5 mouse in the region coding for the hydrophobic ridge loop 3 (HRL3 of the phospholipaseCγ2 (PLCγ-2 gene, corresponding to human PLCγ-2 exon 27, leads to acute and chronic inflammation and granulomatosis. For that reason, we screened exons 11, 12 and 13 coding for the hydrophobic ridge loop 1 and 2 (HRL1 and 2, respectively and exon 27 of the PLCγ-2 protein by single strand conformation polymorphism (SSCP, sequencing and PCR/ restriction fragment length polymorphism (RFLP analyses. In addition, we screened indirectly for disease association via 4 microsatellites with pooled DNA in the PLCγ-2 gene. Results Although a few polymorphisms in these distinct exons were observed, significant differences in allele frequencies were not identified between WG patients and respective controls. In addition, the microsatellite analyses did not reveal a significant difference between our patient and control cohort. Conclusion This report does not reveal any hints for an involvement of the PLCγ-2 gene in the pathogenesis of WG in our case-control study.

  14. Sinonasal Wegener granulomatosis: a single-institution experience with 120 cases.

    Science.gov (United States)

    Cannady, Steven B; Batra, Pete S; Koening, Curry; Lorenz, Robert R; Citardi, Martin J; Langford, Carol; Hoffman, Gary S

    2009-04-01

    Wegener granulomatosis (WG) is intimately associated with the sinonasal tract, with involvement reported in 85% of patients during the course of the disease process. The objectives of the study were: 1) to describe sinonasal symptoms and signs at the time of initial otolaryngologic evaluation; and 2) to review indications and outcomes for rhinologic surgery in WG at our institution. A retrospective analysis of 120 patients presenting with WG and referred for otolaryngology consultation at a tertiary care center was performed. Eighty-nine percent of patients exhibited sinonasal involvement including nasal crusting (69%), chronic rhinosinusitis (CRS) (61%), nasal obstruction (58%), bloody nasal discharge (52%), septal perforation (33%), saddle-nose deformity (23%), epiphora (13%), and mucocele formation (3.3%). Thirty-nine (33%) patients underwent primary functional endoscopic sinus surgery or dacryocystorhinotomy (DCR) prior to referral. Nineteen (16%) patients underwent noncosmetic, functional sinonasal procedures at our institution. These included endoscopic sinus surgery for CRS or mucocele decompression in 14 patients, DCR for chronic epiphora in seven patients, and orbital decompression for pseudotumor in three patients. Individual symptom recurrence within the first year was greatest for visual impairment from pseudotumor (50%), followed by CRS (14%) and nasolacrimal duct obstruction (11%). The majority of patients with WG are referred to otolaryngology because of involvement of the sinonasal tract. Noncosmetic functional sinonasal procedures are indicated in a minority of patients. Sinonasal morbidity remains significant even after surgery. It is greatest for orbital pseudotumor, but also common for CRS and nasolacrimal duct obstruction.

  15. Nasal mucosa narrow band imaging in granulomatosis with polyangiitis (Wegener granulomatosis): A preliminary study.

    Science.gov (United States)

    Trimarchi, Matteo; Bozzolo, Enrica; Pilolli, Francesco; Bertazzoni, Giacomo; Campochiaro, Corrado; Sabbadini, Maria Grazia; Bussi, Mario

    2015-01-01

    Narrow band imaging (NBI) endoscopy is a technique that allows for real-time visualization of mucosal and submucosal vascular patterns. Because granulomatosis with polyangiitis (GPA) (Wegener granulomatosis) is an autoimmune disease defined by vascular inflammation, we examined patients with GPA and with NBI to evaluate whether disease-specific mucosal vascular patterns were present. To the best of our knowledge, the use of NBI endoscopy for assessment of an immune system disease such as GPA has never been previously attempted. We conducted a prospective observational study by performing an endoscopic evaluation of upper airways with NBI on patients diagnosed with GPA; on patients with symptoms and signs suggestive for GPA, who were scheduled to undergo nasal biopsy to confirm diagnosis; on patients affected by chronic rhinosinusitis with nasal polyps; and on healthy controls. We enrolled 69 patients. NBI vascular patterns in patients with GPA were consistently and recognizably different from healthy mucosal patterns in 53% of our cases. In patients with GPA, biopsy and NBI results were for the most part comparable, except for three cases. Nasal mucosa NBI endoscopy can be considered a promising rapid and noninvasive live imaging technique for nasal mucosa GPA that, based on further study, could become a supplementary diagnostic tool in the complex workup of GPA and vasculitis.

  16. Association study with Wegener granulomatosis of the human phospholipase Cγ2 gene

    Science.gov (United States)

    Jagiello, Peter; Wieczorek, Stefan; Yu, Philipp; Csernok, Elena; Gross, Wolfgang L; Epplen, Joerg T

    2005-01-01

    Background Wegener Granulomatosis (WG) is a multifactorial disease of yet unknown aetiology characterized by granulomata of the respiratory tract and systemic necrotizing vasculitis. Analyses of candidate genes revealed several associations, e.g. with α(1)-antitrypsin, proteinase 3 and with the HLA-DPB1 locus. A mutation in the abnormal limb mutant 5 (ALI5) mouse in the region coding for the hydrophobic ridge loop 3 (HRL3) of the phospholipaseCγ2 (PLCγ-2) gene, corresponding to human PLCγ-2 exon 27, leads to acute and chronic inflammation and granulomatosis. For that reason, we screened exons 11, 12 and 13 coding for the hydrophobic ridge loop 1 and 2 (HRL1 and 2, respectively) and exon 27 of the PLCγ-2 protein by single strand conformation polymorphism (SSCP), sequencing and PCR/ restriction fragment length polymorphism (RFLP) analyses. In addition, we screened indirectly for disease association via 4 microsatellites with pooled DNA in the PLCγ-2 gene. Results Although a few polymorphisms in these distinct exons were observed, significant differences in allele frequencies were not identified between WG patients and respective controls. In addition, the microsatellite analyses did not reveal a significant difference between our patient and control cohort. Conclusion This report does not reveal any hints for an involvement of the PLCγ-2 gene in the pathogenesis of WG in our case-control study. PMID:15703080

  17. Granulomatosis with polyangiitis (Wegener's granulomatosis) causing atlantoaxial instability: a case report.

    Science.gov (United States)

    Mohapatra, Anand; Khan, Taleef; Diaz, Jason; Brasington, Richard; Zebala, Lukas P

    2016-10-01

    No previous cases of atlantoaxial instability due to granulomatosis with polyangiitis have been reported. The aim of this study was to report a case of granulomatosis with polyangiitis causing atlantoaxial instability. This is a case report. A 45-year-old woman participated in this study. The patient's pain and atlantoaxial instability were resolved. A 45-year-old Caucasian woman with a large ulcerative lesion in her oropharynx initially presented with chronic sinusitis, pharyngitis, and severe odynophagia. Years after her original symptoms began, she developed neck pain radiating into her upper trapezial region and shoulders. Atlantoaxial fusion was performed on the patient, resolving her neck, upper trapezial, and shoulder pain. She was diagnosed with granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and treated with cyclophosphamide. Granulomatosis with polyangiitis should be part of the working differential diagnosis for non-traumatic cervical spine injury. The atlantoaxial instability can be managed with stabilization, and the disease process itself can be treated with cyclophosphamide. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. [Surgical treatment with dacryocystitis and retinal detachment in a patient with Wegener granulomatosis].

    Science.gov (United States)

    Metoki, Tomomi; Kubo, Masabumi; Takano, Yoshiko; Nakamura, Hideo; Nakazawa, Mitsuru

    2003-06-01

    We report surgical treatment of a patient with dacryocystitis and retinal detachment (RD), which are rare ophthalmic involvements of Wegener granulomatosis (WG). The patient was a 26-year-old man with WG. He was diagnosed as having WG 4 years ago and he has been treated by maintenance doses of predonisolone and cyclophosphamide. Rheumatoid factor and serum antinuclear antibody were negative. Cytoplasmic pattern-antineutrophil cytoplasmic antibody (C-ANCA) and renal function were normal. He was found to have nasolacrimal duct obstruction and lattice degeneration bilaterally, retinal tear with RD in the left eye and tear without RD in the right eye. No sign of vasculitis was found in fluorescein angiography. Bilateral dacryocystorhinostomy was performed without any sign of postoperative necrosis of the wound. After the surgery, epiphora and eye discharge disappeared and lacrimal passage has been maintained without obstruction. The pathological findings of his nasal mucosa and lacrimal sac showed chronic inflammation and no typical changes of WG. There was no abnormal change in the conjunctiva and sclera after an uncomplicated scleral buckling surgery. We conclude that operations such as dacryocystorhinostomy and scleral buckling surgery may be performed successfully when WG is controlled within the normal limits of C-ANCA.

  19. Alfred Donné and Léon Foucault: the first applications of electricity and photography to medical illustration.

    Science.gov (United States)

    Tobin, William

    2006-03-01

    The first electric projecting microscope and the first published photomicrographs harnessed recent technological developments to provide improved methods of medical illustration for educational purposes. Both projects were the work of two Frenchmen. The impetus came from the microscopist Dr Alfred Donné (1801-78), discoverer of trichomonas vaginalis and leukaemia. Implementation was primarily by his medical-student assistant, Léon Foucault (1819-68), who later gained fame as a physicist, especially with his pendulum demonstration of the Earth's rotation.

  20. ‘The man be more of woman, she of man’: Disfarce e Travestismo em The Princess de Alfred Tennyson

    OpenAIRE

    Mendes, Ana Cristina

    2016-01-01

    Numa altura em que se prefigurava o dilema finissecular da reconciliação do feminismo da “New Woman” com o livre arbítrio masculino, Alfred Tennyson parece apresentar no poema The Princess (1847) uma apologia da mulher como elemento fundamental para o homem, em si só incompleto. Este ensaio analisa o motivo do travesti, símbolo no texto da metamorfose necessária para sobreviver até à aquisição da identidade sexual e à inevitável aceitação do Outro, entendido como narrativamente produtivo nest...

  1. Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to tracheobronchial Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    S. A. R. Nouraei

    2008-04-01

    Full Text Available Background: Upper airway compromise due to tracheobronchial stenosis commonly occurs in patients with Wegener's Granulomatosis (WG. There is at present no consensus on the optimal management of this life-threatening condition. Objective: To assess the results of laryngo-tracheo-bronchoscopy, intralesional steroid therapy, laser surgery, and dilatation in managing obstructive tracheobronchial WG. Methods: Records of eighteen previously-untreated stridulous patients with obstructive tracheobronchial WG, treated between 2004 and 2006 were prospectively recorded on an airway database and retrospectively reviewed. Information about patient and lesion characteristics and treatment details were recorded. Treatment progress was illustrated using a timeline plot, and intervention-free intervals were calculated with actuarial analysis. Results: There were nine males and the average age at presentation was 40 (16 years [range 13–74]. There were thirteen patients with tracheal, and five patients with tracheal and bronchial lesions. The average tracheal lesion height was 8 (3 mm, located 23 (9 mm below the glottis. There were 1, 10 and 7 Myer-Cotton grade I, II and III lesions respectively. Mean intervention-free interval following minimally-invasive treatment was 26 (2.8 months. Following endobronchial therapy the median intervention-free interval was 22 months (p>0.8 vs. tracheal lesions. No patient required a tracheostomy or endoluminal stenting. Conclusions: Intralesional steroid therapy and conservative endoluminal surgery is an effective strategy for treating airway compromise due to active tracheal and bronchial WG, obviating the need for airway bypass or stenting. We recommend the combination of endotracheal dilatation, conservative laser surgery and steroid therapy as the standard of care for treating airway compromise due to obstructive tracheobronchial WG.

  2. Sinonasal imaging findings in granulomatosis with polyangiitis (Wegener granulomatosis): A systematic review.

    Science.gov (United States)

    D'Anza, Brian; Langford, Carol A; Sindwani, Raj

    2017-01-01

    Granulomatosis with polyangiitis (GPA) (Wegener granulomatosis) frequently presents in the head and neck, and the sinonasal cavity is among the most common areas affected. Although the clinical findings, histologic appearance, and laboratory workup have been described, characteristic findings and the distribution of disease on sinonasal imaging are not well established. The appropriate imaging modality to evaluate for sinonasal involvement is also unclear. To describe the imaging characteristics, distribution, and location of sinonasal pathology in patients with GPA as noted on computed tomography and magnetic resonance imaging modalities. A systematic review was conducted of English language articles, by using appropriate search terms, which reported the computed tomography and magnetic resonance imaging findings specific to sinonasal disease in adult subjects with GPA. Studies were included only when they focused primarily on specific imaging results in patients with GPA. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A total of 50 articles were identified on an initial search of medical literature data bases. There were seven articles that comprised 224 patients who met inclusion criteria. All the articles were retrospective case series and descriptive in nature. A high incidence of patients with GPA who were imaged showed evidence of pathologic findings. The prevalence of key radiographic findings in patients with GPA were the following: mucosal thickening (87.7% of patients), bony destruction (59.9%), and septal erosion (59.4%). There were no randomized or prospective studies that compared imaging findings between patients with GPA and the controls, and no studies that correlated imaging findings with prognosis. Sinus imaging in GPA revealed a spectrum of nonspecific findings. The constellation of septal erosion, mucosal thickening, and bony changes should raise suspicion for GPA. The current literature was

  3. Clinical manifestations and treatment of idiopathic and Wegener granulomatosis-associated subglottic stenosis.

    Science.gov (United States)

    Taylor, Stanford C; Clayburgh, Daniel R; Rosenbaum, James T; Schindler, Joshua S

    2013-01-01

    To compare and contrast the manifestations and surgical management of subglottic stenosis in patients with airway obstruction attributed to granulomatosis with polyangiitis (GPA), previously known as Wegener granulomatosis, and those with idiopathic subglottic stenosis (iSGS). Retrospective medical chart review. Review of subglottic stenosis cases seen in the otolaryngology department of an academic medical center from 2005 through 2010. Data were obtained on disease presentation, operative management. and findings. Tertiary referral center. A total of 24 patients with iSGS and 15 patients with GPA-associated subglottic stenosis (GPA-SGS). All individuals with iSGS were female, and 40% of patients with GPA-SGS were male (P < .01). Patients with iSGS tended to have a higher Myer-Cotton stenosis grade at the time of dilation than those with GPA-SGS (P = .02). Individuals with GPA-SGS were more likely to undergo tracheotomy as a result of disease-related complications than individuals with iSGS (P < .01). No patients with an open airway reconstruction in the iSGS group required follow-up mechanical dilation. In contrast, all patients with open airway reconstructions in the GPA-SGS group underwent more than 1 subsequent airway dilation (P < .01). While surgical utilization is the mainstay of treatment in iSGS and GPA-SGS, iSGS occurs almost exclusively in females and presents with a greater degree of stenosis at the time of endoscopic dilation. In contrast, GPA-SGS is associated with greater rates of tracheotomy. Open airway reconstruction may be used in the treatment of iSGS and GPA-SGS but is much more effective in iSGS.

  4. Urogenital manifestations in Wegener granulomatosis: a study of 11 cases and review of the literature.

    Science.gov (United States)

    Dufour, Jean-François; Le Gallou, Thomas; Cordier, Jean-François; Aumaître, Olivier; Pinède, Laurent; Aslangul, Elisabeth; Pagnoux, Christian; Marie, Isabelle; Puéchal, Xavier; Decaux, Olivier; Dubois, Alain; Agard, Christian; Mahr, Alfred; Comoz, François; Boutemy, Jonathan; Broussolle, Christiane; Guillevin, Loïc; Sève, Pascal; Bienvenu, Boris

    2012-03-01

    We describe the main characteristics and treatment of urogenital manifestations in patients with Wegener granulomatosis (WG). We conducted a retrospective review of the charts of 11 patients with WG. All patients were men, and their median age at WG diagnosis was 53 years (range, 21-70 yr). Urogenital involvement was present at onset of WG in 9 cases (81%), it was the first clinical evidence of WG in 2 cases (18%), and was a symptom of WG relapse in 6 cases (54%). Symptomatic urogenital involvement included prostatitis (n = 4) (with suspicion of an abscess in 1 case), orchitis (n = 4), epididymitis (n = 1), a renal pseudotumor (n = 2), ureteral stenosis (n = 1), and penile ulceration (n = 1). Urogenital symptoms rapidly resolved after therapy with glucocorticoids and immunosuppressive agents. Several patients underwent a surgical procedure, either at the time of diagnosis (n = 3) (consisting of an open nephrectomy and radical prostatectomy for suspicion of carcinoma, suprapubic cystostomy for acute urinary retention), or during follow-up (n = 3) (consisting of ureteral double J stents for ureteral stenosis, and prostate transurethral resection because of dysuria). After a mean follow-up of 56 months, urogenital relapse occurred in 4 patients (36%). Urogenital involvement can be the first clinical evidence of WG. Some presentations, such as a renal or prostate mass that mimics cancer or an abscess, should be assessed to avoid unnecessary radical surgery. Urogenital symptoms can be promptly resolved with glucocorticoids and immunosuppressive agents. However, surgical procedures, such as prostatic transurethral resection, may be mandatory in patients with persistent symptoms.

  5. Granulomatosis de Wegener Semejando Cáncer Epidermoide de Nasofaringe y Metástasis Pulmonares.

    Directory of Open Access Journals (Sweden)

    Gustavo Adolfo Martín Small

    2009-01-01

    Full Text Available La granulomatosis de Wegener (GW es una enfermedad idiopática, con posible componente autoinmune, que aparece generalmente en la quinta década de vida, caracterizándose por lesiones granulomatosas necrotizantes y vasculitis en vías aéreas y riñón. Paciente femenino de 54 años, quien desde Noviembre del 2008, presenta rinorrea, prurito y eritema en borde nasal inferior izquierdo, recibe antibióticos sin mejoría de los síntomas. En las radiografías torácicas, se observan dos radiopacidades redondeadas, de 4 cm de diámetro, sugestivas de lesiones tumorales en ambos campos pulmonares. La biopsia reporta cáncer epidermoide de alto grado, sospechándose primario en nasofaringe. Es remitida, por deterioro de condiciones, al Servicio de Neumonología del Hospital Universitario de Caracas el 18/03/2009, presentando disnea, tos productiva, placas purpúricas dolorosas en manos y pies, hipoacusia, hiperpigmentación del paladar duro, leucoplaquias y lesiones costrosas en lengua, insuficiencia renal (creatinina en 6,11 mg/dL y trombocitopenia. En TAC de tórax, se evidencian tumores mayores de 5 cm de diámetro, algunos con bordes bien definidos y otros mal delimitados con broncograma aéreo. Diagnostico definitivo de GW por serología. La GW con su afectación sistémica puede simular otras entidades como neoplasias de cabeza y cuello con metástasis pulmonares. Cuando las manifestaciones sistémicas son floridas debe sospecharse GW como diagnóstico diferencial.

  6. James Alfred Loader: ’n Huldeblyk aan ’n krities-solidêre profeet in die eties-teologiese tradisie/James Alfred Loader: A tribute to a critical-solidary prophet in the ethical theological tradition

    Directory of Open Access Journals (Sweden)

    Andries G. van Aarde

    2013-11-01

    Full Text Available This article is the introduction to the James Alfred Loader Dedication. It consists of a tribute to Professor Loader’s academic contribution to Old Testament, Middle-Eastern religio-literary studies and the Rabbinical background of the Old- and New Testament. The article is modelled after the tribute published in German in the annual publication of the Evangelisch-Theologische Fakultät Wien (Vienna, Austria due to the honorary doctorate conferred on Professor Loader by the University of Pretoria (South Africa in 2009. The tribute is combined with a comprehensive curriculum vitae, in part written in German, Afrikaans and English, and consisting of referencing Professor Loader’s personal data, his role as minister of religion, his academic awards, participation in scholarly societies, professional academic positions, academic reviewing, editorial activity, presentation of academic papers and a list of publications.

  7. Book Review: McCoy, Alfred, Policing America’s Empire: The United States, the Philippines, and the Rise of the Surveillance State

    Directory of Open Access Journals (Sweden)

    Salvador Santino F. Regilme, Jr

    2010-01-01

    Full Text Available Book Review of the Monograph: McCoy, Alfred (2009, Policing America’s Empire: The United States, the Philippines, and the Rise of the Surveillance State, Madison, Wisconsin: The University of Wisconsin Press ISBN 978-0-299-23414-0, 659 pages

  8. Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis : first results from a multicentre study

    NARCIS (Netherlands)

    Csernok, E; Holle, J; Hellmich, B; Willem, J; Tervaert, C; Kallenberg, CGM; Limburg, PC; Niles, J; Pan, GL; Specks, U; Westman, K; Wieslander, J; Gross, WL

    Objective: To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories. Methods: Serum samples were derived from patients with histological and clinical diagnosis of WG (n = 60),

  9. PSYCHOLOGY IN FRENCH ACADEMIC PUBLISHING IN THE LATE NINETEENTH CENTURY: ALFRED BINET, EDITORIAL DIRECTOR AT THE SCHLEICHER PUBLISHING HOUSE.

    Science.gov (United States)

    Nicolas, Serge

    2015-01-01

    To date, historians of psychology have largely ignored the role of academic publishing and the editorial policies of the late nineteenth century. This paper analyzes the role played by academic publishing in the history of psychology in the specific case of France, a country that provides a very interesting and unique model. Up until the middle of the 1890s, there was no collection specifically dedicated to psychology. Alfred Binet was the first to found, in 1897, a collection of works specifically dedicated to scientific psychology. He chose to work with Reinwald-Schleicher. However, Binet was soon confronted with (1) competition from other French publishing houses, and (2) Schleicher's management and editorial problems that were to sound the death knell for Binet's emerging editorial ambitions. The intention of this paper is to encourage the efforts of the pioneers of modern psychology to have their work published and disseminated. © 2015 Wiley Periodicals, Inc.

  10. Las fenomenologías poshusserlianas de Alfred Schutz y Niklas Luhmann: soluciones para el problema de la intersubjetividad

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    Pignuoli Ocampo, Sergio

    2015-12-01

    Full Text Available In this article we focus on the reception given by Luhmann to the works of Alfred Schutz. We compare both treatments to the phenomenological problem of intersubjectivity. Our hypothesis is that Luhmann developed an original poshusserlian phenomenological position, in dialog with Schutz.Este trabajo aborda la recepción dada por Luhmann a la obra de Schutz, en cuyo marco comparamos los tratamientos dados por ambos a los problemas fenomenológicos de la experiencia del otro y de la intersubjetividad. Nuestra hipótesis es que Luhmann desarrolló una posición fenomenológica original, de cuño poshusserliano, en dialogo privilegiado con Schutz.

  11. Alfred Pischinger (1899-1983): An Austrian career in anatomy continuing through National Socialism to postwar leadership.

    Science.gov (United States)

    Hildebrandt, Sabine; Czarnowski, Gabriele

    2017-05-01

    Despite intensified research efforts on the history of anatomy during National Socialism (NS), many aspects of this story still need further investigation. This study explores the life, work and politics of Alfred Pischinger, Chairman of the Institute for Embryology and Histology in Graz from 1936 to 1945, and in Vienna from 1958 to 1970, and is an addition to previous reports on careers in anatomy continuing through the Third Reich to the postwar period. Pischinger was an illegal NSDAP member in Austria, joined the SA in 1938, served as expert in racial hygiene, and as judge on the Genetic Health High Court of Graz. His research focus was histochemistry, but he became part of a scientific network at the University of Graz, which from 1939 on experimented on the bodies of pregnant women and their fetuses under the leadership of gynecologist Karl Ehrhardt. The researchers were among the many who took actively part in the complete exploitation and physical destruction of those considered to be "the enemy" by the NS regime. After the war, Pischinger received publicity for his work on the "scientific basis" of alternative and holistic approaches of medicine. His NS past and fetal experiments seem to have vanished from public knowledge. As systematic studies of the influence of the NS period on postwar medical education and the science of anatomy itself are still missing, this critical investigation of Alfred Pischinger's life within the relevant historic background aims to contribute to this body of knowledge. Copyright © 2017 Elsevier GmbH. All rights reserved.

  12. Thermal Models of the Ocean Floor: from Wegener to Cerro Prieto

    Science.gov (United States)

    Sclater, J. G.; Negrete-Aranda, R.

    2017-12-01

    Wegener (1925) argued that hot rock could explain the shallower depths of ridges in the center of the Atlantic Ocean. Hess (1963) proposed that the intrusion of molten rock occurred at a world encircling mid-ocean ridge system. However, he accounted for the elevation of the ridges by the formation of serpentinite and thermal convection. Langseth et al. (1966) provided the major advance by using a 100 km thick plate to argue such a concept could not explain the depth, heat flow versus distance relations. They had the correct model but misinterpreted the data. Reformulating theoretically, McKenzie (1967) created the generally accepted thermal model for the ocean floor. Unfortunately, in attempting to match erroneously low heat flow data, he used a 50 km thick plate. Addition of the effect of water and the realization of the importance of advective flow, enabled various groups to create thermal plate models that accounted for the heat flow and depth age relations. From this came the understanding of hydrothermal circulation in the oceanic crust, the thermal boundary layer concept of the oceanic plate and the realization that all thermal models differed only in the way the different groups had chosen to analyze the data. During the past 40 years many have applied similar concepts to continental margins: (1) Measurement of subsidence of the Atlantic margin, continental stretching and a Time Temperature, Depth and Maturation analysis of continental basins have created the field of Basin Analysis; (2) Changes in heat flow at ocean continent boundaries have determined the position of the transition and (3) In attempting to examine the ocean continent transition process in the northernmost basin of the Gulf of California, Neumann et al (in press) observed conductive heat flow values greater than 0.75 Watts, at a depth of < 150 m, along a 10 km section of a profile across the southern extension of the Cerro Prieto fault. The magnitude of these values overwhelms local

  13. Effects of Wegener-Bergeron-Findeisen Process on Global Black Carbon Distribution

    Science.gov (United States)

    Qi, L.

    2016-12-01

    In mixed-phase clouds, the Wegener-Bergeron-Findeisen (WBF) process (ice crystals may grow while water drops evaporate, thereby releasing black carbon (BC) particles into the interstitial air) slows down wet scavenging of BC. Rimming (snowflakes fall and collect cloud water drops and the BC in them along their pathways), in contrast, results in more efficient wet scavenging. We systematically investigate the effects of WBF on BC scavenging efficiency, surface BCair, deposition flux, concentration in snow, and washout ratio using a global 3D chemical transport model. We differentiate riming- vs WBF-dominated in-cloud scavenging based on liquid water content and temperature. Specifically, we relate WBF to either temperature or ice mass fraction in mixed-phase clouds. We find that at Jungfraujoch, Switzerland and Abisko, Sweden, where WBF dominates, the discrepancies of simulated BC scavenging efficiency and washout ratio are significantly reduced (from a factor of 3 to 10% and from a factor of 4-5 to a factor of two). However, at Zeppelin, Norway, where riming dominates, simulation of BC scavenging efficiency, BCair, and washout ratio become worse (relative to observations) when WBF is included. There is thus an urgent need for extensive observations to distinguish and characterize riming- versus WBF-dominated aerosol scavenging in mixed-phase clouds and the associated BC scavenging efficiency. We find the reduction resulting from WBF to global BC scavenging efficiency varies substantially, from 8% in the tropics to 76% in the Arctic. The resulting annual mean BCair increases by up to 156% at high altitudes and at northern high latitudes. Overall, WBF halves the model-observation discrepancy (from -65% to -30%) of BCair across North America, Europe, China and the Arctic. Globally WBF increases BC burden from 0.22 to 0.29-0.35 mg m-2 yr-1, which partially explains the gap between observed and previous model simulated BC burdens over land (Bond et al., 2013). In

  14. Effect of Wegener-Bergeron-Findeisen Process to Black Carbon Simulation

    Science.gov (United States)

    Qi, Ling; Li, Qinbin; He, Cenlin; Wang, Xin; Huang, Jianping

    2016-04-01

    We systematically investigated the effect of Wegener-Bergeron-Findeisen (WBF) process to black carbon (BC) simulation by a global 3D chemical transport model GEOS-Chem constrained by measurements of BC scavenging efficiencies, concentration in air, deposition fluxes, concentration in snow and washout ratios. Including effect of WBF process reduces the annual mean BC scavenging efficiencies (the ratio of BC in cloud droplets to total BC) at all altitudes by 43-76% in the Arctic. For mid latitude BC scavenging efficiencies decrease by 8-22%, 23-39%, and 41-50% in lower (0-2 km), middle (2-5 km) and upper troposphere (5-10 km), respectively. Simulated BC in air in the Arctic and at mid altitude (˜4 km) in mid latitude increases by ˜40%, and the discrepancy reduces from -65% to -30%. Simulated median BC in snow decreases from 25.7 to 22.4 ng g-1, by 15% in mid latitude and increases from 8.7 to 11.0 ng g-1, by 26% in the Arctic and the comparison with observations improves. The model overestimates washout ratios (ratio of BC in fresh snow/rain to BC in surface air) at most of the sites by up to a factor of 165. With effect of WBF process included, the discrepancy decreases to a factor of 72. The simulated BC burden increases from 0.22 to 0.35 mg m-2 yr-1 when effect of WBF process is included, partly explains the scaled up of BC burden in Bond et al., 2013. Moreover, burden above 5 km increases from 22% to 27% when WBF process is included, indicating a higher forcing efficiency. We also found that BC simulation is insensitive to the temperature criteria between mixed phase clouds and ice clouds. The simulated BC burden is the same when the temperature is set as -15° C and -25° C. This study also suggests that more observations are needed to better distinguish riming dominated and WBF dominated conditions and better parameterize BC scavenging efficiency under the two conditions.

  15. How Earth works 100 years after Wegener's continental drift theory and IGCP 648

    Science.gov (United States)

    Li, Z. X.; Evans, D. A.; Zhong, S.; Eglington, B. M.

    2015-12-01

    It took half a century for Wegener's continental drift theory to be accepted as a fundamental element of the plate tectonic theory. Another half a century on, we are still unsure of the driving mechanism for plate tectonics: is it dominated by thermal convection, gravitational forces, or by a combination of mechanisms? Nonetheless, breakthroughs in the past decades put us in a position to make a major stride in answering this question. These include: (1) widely accepted cyclic occurrences of supercontinent assembly and break-up (whereas random occurrence of supercontinents was an equal possibility in the 1990s); (2) the discovery of two equatorial and antipodal large low seismic velocity provinces (LLSVPs) that dominate the lower mantle and appear to have been the base for almost all mantle plumes since at the Mesozoic, and of subduction of oceanic slabs all the way to the core-mantle boundary, which together suggesting whole-mantle convection; (3) the recognition of true polar wander (TPW) as an important process in Earth history, likely reflecting Earth's major internal mass redistribution events; and (4) rapidly enhancing computer modelling power enabling us to simulate all aspect of Earth's dynamic inner working. Many new yet often controversial ideas have been proposed, such a possible coupling in time (with an offset) and space between supercontinent cycle and superplume (LLSVP) events which oppose to the idea of static and long-lived LLSVPs, and the orthoversion v.s. introversion or extroversion models for supercontinent transition. To fully utilise these advances as well as the rapidly expanding global geoscience databases to address the question of how Earth works, an UNESCO-IUGS sponsored IGCP project No. 648 was formed to coordinate a global cross-disciplinary effort. We aim to achieve a better understanding of the supercontinent cycle, and examine the relationship between supercontinent cycle and global plume events. We will establish a series of global

  16. Long-term outcome of airway stenosis in granulomatosis with polyangiitis (Wegener granulomatosis): an observational study.

    Science.gov (United States)

    Martinez Del Pero, Marcos; Jayne, David; Chaudhry, Afzal; Sivasothy, Pasupathy; Jani, Piyush

    2014-11-01

    Airway stenosis occurs in patients with granulomatosis with polyangiitis (GPA or Wegener granulomatosis). It produces significant morbidity and contributes to mortality. To investigate the frequency and distribution of airway stenoses in GPA and evaluate the efficacy of local interventions in maintaining airway patency. A retrospective single-center study of 44 patients with GPA and airway stenosis assessed and treated as needed by a multidisciplinary team at a university medical center between 1997 and 2012. The median duration of observation for each patient from the time of diagnosis was 146 months. Patients who had critical stenoses underwent either dilatation or laser radial cuts to the lesion. In some cases, intralesional administration of steroids or topical mitomycin C was used. The main outcome measure was airway patency for at least 12 months and the number of interventions required to achieve this end point. Details of patients and interventions were recorded at baseline and at each treatment. The median age at diagnosis was 37.6 years; 73% of patients were women (n = 34). The median follow-up after the initial intervention was 62.5 months. Subglottic stenosis was found in 36 patients, lower airway stenosis in 30. There were 213 interventions in 39 patients, including balloon and bougie dilatation and laser treatment. Adjuvant local treatment was used in 71 interventions. A 12-month period of airway stability was achieved in 34 of 36 cases (97%) (5 had no procedures and 3 had follow-up shorter than 12 months). The median interval between procedures was 4.9 months, and after the last intervention recorded, patients had at least 27 months of airway stability. Fourteen adverse events were recorded (6.6%). The frequency and distribution of airway stenoses in 44 patients with GPA has been described. In the 39 patients who required intervention, multiple procedures were required, but 97% then achieved a prolonged period of airway patency. The procedures and

  17. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria

    DEFF Research Database (Denmark)

    Ozen, Seza; Pistorio, Angela; Iusan, Silvia M

    2010-01-01

    To validate the previously proposed classification criteria for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA)....

  18. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria

    DEFF Research Database (Denmark)

    Ozen, Seza; Pistorio, Angela; Iusan, Silvia M

    2010-01-01

    To validate the previously proposed classification criteria for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA).......To validate the previously proposed classification criteria for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA)....

  19. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation

    DEFF Research Database (Denmark)

    Ruperto, Nicolino; Ozen, Seza; Pistorio, Angela

    2010-01-01

    To report methodology and overall clinical, laboratory and radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) classification criteria.......To report methodology and overall clinical, laboratory and radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) classification criteria....

  20. Aportes de la teoría social de Alfred Schutz para pensar la política y la acción colectiva Contributions of Alfred Schutz's social theory to think politics and collective action

    Directory of Open Access Journals (Sweden)

    Mariela Hemilse Acevedo

    2011-12-01

    Full Text Available Partiendo del interrogante acerca de qué elementos de la fenomenología social de Alfred Schutz pueden ser pertinentes para pensar la política y la acción colectiva, el interés en estas páginas estará puesto en exponer los planteos de Schutz acerca del lugar de los sistemas significativos y las representaciones simbólicas en la relación del hombre con el mundo, con el orden social y el orden político, y señalar los aportes de estos planteos a la reflexión sobre el accionar colectivo y la política. Para ello, se exponen brevemente algunas formulaciones de la teoría schutzeana del conocimiento del mundo, su teoría de las referencias apresentacionales y la simbolización, así como también sus referencias al papel de las estructuras de significatividades en la interpretación del mundo y en la acción, y se indaga la manera en que estos desarrollos de la teoría de Schutz son retomados por Ilja Srubar y por Daniel Cefaï para pensar la política.Starting from the question about which aspects of the social phenomenology of Alfred Schutz may be relevant to thinking about politics and collective action, interest in these pages will be on exposing the proposals of Schutz's place of systems of relevance and symbolic representations in the relationship between man and the world in social and political order, and noted the contributions of these approaches to the reflection on the collective action and politics. For this, it briefly describes some formulations of the theory schutzeana knowledge of the world, his theory of the references apresentacionales and symbolization, as well as references to the role of the structures of significance in the interpretation of the world and action, and it examines how these developments of the theory of Schutz are taken up by Ilja Srubar and Daniel Cefaï to think politics.

  1. Tumour necrosis factor-alpha (TNF), lymphotoxin and TNF receptor levels in serum from patients with Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Jónasdóttir, O; Petersen, J; Bendtzen, K

    2001-01-01

    Wegener's granulomatosis (WG) is a systemic inflammatory disease with vasculitis as the key feature. Abnormal expression of tumour necrosis factor alpha (TNFalpha) is considered of prime pathogenic importance in several inflammatory diseases. The effects of TNFa are mediated by TNF receptors (TNF......-R), and these receptors are often found in soluble forms (sTNF-R), which can modulate TNFalpha actions. To evaluate the clinical importance of the TNF family of cytokines, the serum levels of TNFalpha, TNFbeta, now termed lymphotoxin (LTalpha), and sTNF-R1 and sTNF-R2 were measured by ELISA in 8 patients with WG during...... active disease and during immunosuppressive treatment, and in 11 healthy controls in parallel. Serum concentrations of TNFalpha were undetectable in all except two controls (18%) and three patients with WG (37%). After 7 days of therapy, six of the WG patients had measurable TNFalpha levels. Examination...

  2. Progressive multifocal encephalopathy after cyclophosphamide in granulomatosis with polyangiitis (Wegener) patients: case report and review of literature.

    Science.gov (United States)

    Pugnet, G; Pagnoux, C; Bézanahary, H; Ly, K H; Vidal, E; Guillevin, L

    2013-01-01

    Progressive multifocal encephalopathy (PML) is a rare demyelinating disorder targeting the central nervous system and resulting from JC virus reactivation. PML occurs in patients immunocompromised because of haematological malignancies, HIV infection or treatment with cytotoxic drugs. Herein, we describe PML occurring in 2 granulomatosis with polyangiitis (Wegener) patients treated with steroids and cyclophosphamide. The outcome was progressively favourable after immunosuppressant discontinuation for 1 patient and fatal for the other. Four previously reported GPA patients developed PML in the course of their disease. One of them improved gradually after immunosuppressant withdrawal. PML should be strongly suspected whenever unusual central neurological manifestations appear in this context. No effective treatment is available, but immunosuppressants should be discontinued if possible.

  3. 18F-FDG PET/CT findings preceded elevation of serum proteinase 3 antineutrophil cytoplasmic antibodies in Wegener granulomatosis.

    Science.gov (United States)

    Ito, Kimiteru; Minamimoto, Ryogo; Yamashita, Hiroyuki; Morooka, Miyako; Okasaki, Momoko; Mimori, Akio; Kubota, Kazuo

    2014-01-01

    A 67-year-old woman underwent F-FDG PET/CT after developing a fever of unknown origin. PET/CT revealed intensive FDG uptake at the nasal and lung lesions. On the laboratory data, serum myeloperoxidase antineutrophil cytoplasmic antibodies (ANCA) titer was elevated, although serum directed against proteinase 3 (PR3) ANCA titer was within normal limits. One month after treatment, follow-up PET/CT revealed decreased FDG uptake at the lesions. One year later, serum PR3-ANCA titer elevated, which finally led to a diagnosis of Wegener granulomatosis (WG). WG lesions may be detected earlier by FDG PET/CT than by serum PR3-ANCA titers.

  4. Intense FDG uptake on PET/CT in the upper and lower respiratory system indicative of Wegener's granulomatosis.

    Science.gov (United States)

    Aydin, M; Akkoyunlu, M E; Yakar, F; Ergul, N; Sezer, M

    2014-01-01

    Wegener's granulomatosis (WG) is an uncommon systemic vasculitis, which involves the upper and lower respiratory tracts and the kidneys. Because the patients generally present with clinical manifestations that are similar to common diseases, WG may be initially misdiagnosed as infection or malignancy. We report the case of a 55-year-old male presenting with weight loss, cough, hemoptysis, low-grade fever, and pulmonary nodules detected on the thoracic CT scan. Malignancy was initially suspected, so a PET/CT was performed. It demonstrated intense FDG uptake in the upper and lower respiratory system. The diagnosis of WG was based on PET findings, elevated serum levels of inflammatory markers, and the presence of c-ANCA. We consider that the knowledge of FDG-PET/CT findings may help to make an easier and earlier diagnosis of WG. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  5. Pulmonary Wegener' s granulomatosis. Correlation between high-resolution CT findings and clinical scoring of disease activity

    International Nuclear Information System (INIS)

    Schnabel A, Reuter M; Tetzlaff K, Wesner F

    1999-01-01

    It has been considered that the treatment to the patient with Wegener granulomatosis (WG) it should be adapted to the activity of the illness. In this work it was looked for to evaluate if the discoveries in the high-resolution tomography of thorax of in several clinical stadiums of the illness were correlated with the clinical score of activity of the illness. 73 patients were studied with WG (30 women, 43 men) with age between 34 and 71 years. They were carried out 98 radiological exams. The pursuit was made with bronchoscopy, BAL, tests of pulmonary function, Rx thorax. The high-resolution tomography was taken before the bronchoscopy and it was the base for the realization of the BAL. Patient with Rx normal thorax they were also included

  6. High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's)

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Obel, Niels; Baslund, Bo

    2014-01-01

    OBJECTIVE: To assess the incidence of stroke, pulmonary embolism (PE), and deep venous thrombosis (DVT) in granulomatosis with polyangiitis (Wegener's) (GPA). METHODS: Patients diagnosed with GPA at a Danish tertiary care center during 1993-2011 were identified (n = 180). Each patient was matched...... with 19 population controls (n = 3,420). Information on hospitalizations for stroke, PE, and DVT was obtained from the Danish National Hospital Register. The occurrence of vascular events in the GPA cohort was compared with that in the control group by calculation of incidence rate ratios (IRRs). RESULTS......: The median duration of followup was 7.2 years (interquartile range 3.1-11.7 years) in the GPA cohort. Within the first 2 years following the diagnosis of vasculitis, the incidences of PE and DVT were substantially increased among the patients (IRR 25.7 [95% confidence interval (95% CI) 6.9-96] for PE and IRR...

  7. Tumour necrosis factor-alpha (TNF), lymphotoxin and TNF receptor levels in serum from patients with Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Jónasdóttir, O; Petersen, J; Bendtzen, K

    2001-01-01

    Wegener's granulomatosis (WG) is a systemic inflammatory disease with vasculitis as the key feature. Abnormal expression of tumour necrosis factor alpha (TNFalpha) is considered of prime pathogenic importance in several inflammatory diseases. The effects of TNFa are mediated by TNF receptors (TNF......-R), and these receptors are often found in soluble forms (sTNF-R), which can modulate TNFalpha actions. To evaluate the clinical importance of the TNF family of cytokines, the serum levels of TNFalpha, TNFbeta, now termed lymphotoxin (LTalpha), and sTNF-R1 and sTNF-R2 were measured by ELISA in 8 patients with WG during...... of the relative amounts of TNFalpha and sTNF-R indicated that TNFalpha was mostly bound to its soluble receptors. In WG, the serum levels of sTNF-R1 and sTNF-R2 were dramatically increased (p...

  8. Serial High-Resolution Computed Tomography Imaging in Patients with Wegener Granulomatosis: Differentiation Between Active Inflammatory and Chronic Fibrotic Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Lohrmann, C.; Uhl, M.; Schaefer, O.; Ghanem, N.; Kotter, E.; Langer, M. [Univ. Hospital of Freiburg (Germany). Dept. of Radiology

    2005-08-01

    PURPOSE: To evaluate pulmonary pathologies in Wegener granulomatosis with sequential computed tomography (CT) in order to differentiate active inflammatory lesions from chronic fibrotic lesions. MATERIAL AND METHODS: Serial CT findings in 38 patients with Wegener granulomatosis were retrospectively analyzed (mean follow-up period, 21 months). The presence, extension, and distribution of the following findings were evaluated with CT: parenchymal nodules, masses, ground-glass attenuation, airspace consolidation, bronchial wall-thickening, bronchiectasis, linear areas of attenuation, pleural irregularities, pleural effusions, hilar and mediastinal lymphadenopathy. RESULTS: Observed in 92% of patients, nodules were the most common CT pathology. Areas of ground-glass attenuation, consolidation, masses of linear attenuation, and tracheal/bronchial wall-thickening were detected in 24%, 26%, 32%, 39%, and 68% of patients. At follow-up, the clearance of lesions was most consistent for areas of ground-glass attenuation (89%), masses (87%), and cavitated nodules (85%). In the follow-up scan, 58% of all nodules, 47% of pulmonary consolidations, and 66% of bronchial wall-thickening were completely resolved. Areas of bronchiectasis and septal/non-septal lines remained stable in 70% and 71% of patients. CONCLUSION: The majority of the lesions decreased or resolved completely with or without areas of linear attenuation. Ground-glass attenuation, cavitated nodules and masses appear to represent active inflammatory lesions. In most probability, areas of bronchiectasis and septal/non-septal lines more often represent chronic fibrotic changes rather than active inflammatory changes. In combination with clinical evaluation and bronchoscopy, CT assists in the assessment of disease activity.

  9. Effects of the Wegener-Bergeron-Findeisen process on global black carbon distribution

    Science.gov (United States)

    Qi, Ling; Li, Qinbin; He, Cenlin; Wang, Xin; Huang, Jianping

    2017-06-01

    We systematically investigate the effects of Wegener-Bergeron-Findeisen process (hereafter WBF) on black carbon (BC) scavenging efficiency, surface BCair, deposition flux, concentration in snow (BCsnow, ng g-1), and washout ratio using a global 3-D chemical transport model (GEOS-Chem). We differentiate riming- versus WBF-dominated in-cloud scavenging based on liquid water content (LWC) and temperature. Specifically, we implement an implied WBF parameterization using either temperature or ice mass fraction (IMF) in mixed-phase clouds based on field measurements. We find that at Jungfraujoch, Switzerland, and Abisko, Sweden, where WBF dominates in-cloud scavenging, including the WBF effect strongly reduces the discrepancies of simulated BC scavenging efficiency and washout ratio against observations (from a factor of 3 to 10 % and from a factor of 4-5 to a factor of 2). However, at Zeppelin, Norway, where riming dominates, simulation of BC scavenging efficiency, BCair, and washout ratio become worse (relative to observations) when WBF is included. There is thus an urgent need for extensive observations to distinguish and characterize riming- versus WBF-dominated aerosol scavenging in mixed-phase clouds and the associated BC scavenging efficiency. Our model results show that including the WBF effect lowers global BC scavenging efficiency, with a higher reduction at higher latitudes (8 % in the tropics and up to 76 % in the Arctic). The resulting annual mean BCair increases by up to 156 % at high altitudes and at northern high latitudes because of lower temperature and higher IMF. Overall, WBF halves the model-observation discrepancy (from -65 to -30 %) of BCair across North America, Europe, China and the Arctic. Globally WBF increases BC burden from 0.22 to 0.29-0.35 mg m-2 yr-1, which partially explains the gap between observed and previous model-simulated BC burdens over land. In addition, WBF significantly increases BC lifetime from 5.7 to ˜ 8 days. Additionally

  10. On the Wegener granulomatosis associated region on chromosome 6p21.3

    Directory of Open Access Journals (Sweden)

    Csernok Elena

    2006-03-01

    Full Text Available Abstract Background Wegener granulomatosis (WG belongs to the heterogeneous group of systemic vasculitides. The multifactorial pathophysiology of WG is supposedly caused by yet unknown environmental influence(s on the basis of genetic predisposition. The presence of anti-neutrophil cytoplasmic antibodies (ANCA in the plasma of patients and genetic involvement of the human leukocyte antigen system reflect an autoimmune background of the disease. Strong associations were revealed with WG by markers located in the major histocompatibility complex class II (MHC II region in the vicinity of human leukocyte antigen (HLA-DPB1 and the retinoid X receptor B (RXRB loci. In order to define the involvement of the 6p21.3 region in WG in more detail this previous population-based association study was expanded here to the respective 3.6 megabase encompassing this region on chromosome 6. The RXRB gene was analysed as well as a splice-site variation of the butyrophilin-like (BTNL2 gene which is also located within the respective region. The latter polymorphism has been evaluated here as it appears as a HLA independent susceptibility factor in another granulomatous disorder, sarcoidosis. Methods 150–180 German WG patients and a corresponding cohort of healthy controls (n = 100–261 were used in a two-step study. A panel of 94 microsatellites was designed for the initial step using a DNA pooling approach. Markers with significantly differing allele frequencies between patient and control pools were individually genotyped. The RXRB gene was analysed for single strand conformation polymorphisms (SSCP and restriction fragment length polymorphisms (RFLP. The splice-site polymorphism in the BTNL2 gene was also investigated by RFLP analysis. Results A previously investigated microsatellite (#1.0.3.7, Santa Cruz genome browser (UCSC May 2004 Freeze localisation: chr6:31257596-34999883, which was used as a positive control, remained associated throughout the whole two

  11. On the Wegener granulomatosis associated region on chromosome 6p21.3

    Science.gov (United States)

    Szyld, Paweł; Jagiello, Peter; Csernok, Elena; Gross, Wolfgang L; Epplen, Joerg T

    2006-01-01

    Background Wegener granulomatosis (WG) belongs to the heterogeneous group of systemic vasculitides. The multifactorial pathophysiology of WG is supposedly caused by yet unknown environmental influence(s) on the basis of genetic predisposition. The presence of anti-neutrophil cytoplasmic antibodies (ANCA) in the plasma of patients and genetic involvement of the human leukocyte antigen system reflect an autoimmune background of the disease. Strong associations were revealed with WG by markers located in the major histocompatibility complex class II (MHC II) region in the vicinity of human leukocyte antigen (HLA)-DPB1 and the retinoid X receptor B (RXRB) loci. In order to define the involvement of the 6p21.3 region in WG in more detail this previous population-based association study was expanded here to the respective 3.6 megabase encompassing this region on chromosome 6. The RXRB gene was analysed as well as a splice-site variation of the butyrophilin-like (BTNL2) gene which is also located within the respective region. The latter polymorphism has been evaluated here as it appears as a HLA independent susceptibility factor in another granulomatous disorder, sarcoidosis. Methods 150–180 German WG patients and a corresponding cohort of healthy controls (n = 100–261) were used in a two-step study. A panel of 94 microsatellites was designed for the initial step using a DNA pooling approach. Markers with significantly differing allele frequencies between patient and control pools were individually genotyped. The RXRB gene was analysed for single strand conformation polymorphisms (SSCP) and restriction fragment length polymorphisms (RFLP). The splice-site polymorphism in the BTNL2 gene was also investigated by RFLP analysis. Results A previously investigated microsatellite (#1.0.3.7, Santa Cruz genome browser (UCSC) May 2004 Freeze localisation: chr6:31257596-34999883), which was used as a positive control, remained associated throughout the whole two-step approach

  12. Magnetic resonance imaging and computed tomography of the orbit in Wegener's granulomatosis. Magnetresonanztomographie und Computertomographie der Wegenerschen Granulomatose der Orbita

    Energy Technology Data Exchange (ETDEWEB)

    Muhle, C. (Klinik fuer Radiologische Diagnostik, Kiel (Germany)); Noelle, B. (Klinik fuer Ophthalmologie, Univ. Kiel (Germany)); Brinkmann, G. (Klinik fuer Radiologische Diagnostik, Kiel (Germany)); Schubert, F. (Klinik fuer Radiologische Diagnostik, Kiel (Germany)); Reinhold-Keller, E. (Poliklinik fuer Klinische Rheumatologie, Univ. Luebeck (Germany) Medizinische Krankenhausabteilung, Rheumaklinik Bad Bramstedt (Germany)); Spielmann, R.P. (Klinik fuer Radiologische Diagnostik, Kiel (Germany)); Reuter, M. (Klinik fuer Radiologische Diagnostik, Kiel (Germany))

    1994-09-01

    Of a total of 121 patients with histological proven Wegener's Granulomatosis, orbital involvement occurred in 12 cases. Eight of them underwent magnetic resonance imaging (MRI) of the head and brain, in 2 cases computed tomography (CT) was additionally performed. With MRI orbital granulomas had a low signal intensity in T[sub 1]- and T[sub 2]-weighted spin-echo sequences. After i.v. contrast medium administration an inhomogeneous enhancement was found. Because of the multiple imaging planes and high soft tissue contrast, orbital granulomas were better delineate with regard to the intraorbital muscles and the optic nerve using MRI than with CT. Osseous destruction and sclerosis of the orbital walls were demonstrated more effectively using CT. MRI and CT are thus complementary for diagnosing and staging, of orbital granulomas and periorbital involvement in Wegener's Granulomatosis. (orig.)

  13. High-resolution CT (HRCT) of the lung in Wegener's granulomatosis. High-Resolution CT (HRCT) der Lunge bei Wegenerscher Granulomatose

    Energy Technology Data Exchange (ETDEWEB)

    Schubert, F. (Klinik fuer Radiologische Diagnostik, Kiel Univ. (Germany)); Muhle, C. (Klinik fuer Radiologische Diagnostik, Kiel Univ. (Germany)); Schnabel, A. (Medizinische Abt., Rheumaklinik Bad Bramstedt (Germany) Abt. fuer Klinische Rheumatologie, Luebeck Univ. (Germany)); Handrock, K. (Medizinische Abt., Rheumaklinik Bad Bramstedt (Germany) Abt. fuer Klinische Rheumatologie, Luebeck Univ. (Germany)); Reuter, M. (Klinik fuer Radiologische Diagnostik, Kiel Univ. (Germany)); Spielmann, R.P. (Klinik fuer Radiologische Diagnostik, Kiel Univ. (Germany)); Gross, W.L. (Medizinische Abt., Rheumaklinik Bad Bramstedt (Germany) Abt. fuer Klinische Rheumatologie, Luebeck Univ. (Germany)); Heller, M. (Klinik fuer Radiologische Diagnostik, Kiel Univ. (Germany))

    1994-07-01

    HRCT of the lung and plain chest X-ray were performed to reveal pulmonary manifestation in primary diagnostics or reevaluation of 35 patients with Wegener's granulomatosis. Pleural and parenchymal pathology was detected in chest X-ray of 20 (57%) and in HRCT of 30 (85,7%) patients. Granulomas with and without cavitations and with smooth or spiculated margins were deemed pathognomonic. Nonspecific findings were infiltrates, thickened interlobular septae and fibrotic changes of parenchyma and pleura. Ground glass opacities, traction bronchiectasis and small cysts were only visible on HRCT. As expected HRCT proved to be more sensitive in detecting subtle lung alterations than plain film chest X-ray. It helps to differentiate acute inflammatory and thus potentially curable processes from chronic fibrotic changes in Wegener's granulomatosis. (orig.)

  14. Alfred Russel Wallace (1823-1913): the forgotten co-founder of the Neo-Darwinian theory of biological evolution.

    Science.gov (United States)

    Kutschera, Ulrich; Hossfeld, Uwe

    2013-12-01

    The British naturalist Alfred Russel Wallace (1823-1913), who had to leave school aged 14 and never attended university, did extensive fieldwork, first in the Amazon River basin (1848-1852) and then in Southeast Asia (1854-1862). Based on this experience, and after reading the corresponding scientific literature, Wallace postulated that species were not created, but are modified descendants of pre-existing varieties (Sarawak Law paper, 1855). Evolution is brought about by a struggle for existence via natural selection, which results in the adaptation of those individuals in variable populations who survive and reproduce (Ternate essay, 1858). In his monograph Darwinism (1889), and in subsequent publications, Wallace extended the contents of Darwin's Origin of Species (1859) into the Neo-Darwinian theory of biological evolution, with reference to the work of August Weismann (1834-1914). Wallace also became the (co)-founder of biogeography, biodiversity research, astrobiology and evolutionary anthropology. Moreover, he envisioned what was later called the anthropocene (i.e., the age of human environmental destructiveness). However, since Wallace believed in atheistic spiritualism and mixed up scientific facts and supernatural speculations in some of his writings, he remains a controversial figure in the history of biology.

  15. THE IMPORTANCE OF INSTRUMENT MAKERS FOR THE DEVELOPMENT OF EXPERIMENTAL PSYCHOLOGY: THE CASE OF ALFRED BINET AT THE SORBONNE LABORATORY.

    Science.gov (United States)

    Nicolas, Serge

    2016-07-01

    The importance of instrument firms in the development of psychology, and science in general, should not be underestimated since it would not have been possible for various leading psychologists at the turn of the twentieth century to conduct certain experiments without the assistance of instrument makers, as is often the case today. To illustrate the historical perspective introduced here, the example of Alfred Binet is taken, as he is an interesting case of a psychologist working in close collaboration with various French instrument designers of the time. The objective of this article is twofold: (1) to show the considerable activity carried out by early psychologists to finalize new laboratory instruments in order to develop their research projects; (2) to reassess the work of a major figure in French psychology through his activity as a designer of precision instruments. The development of these new instruments would certainly have been difficult without the presence in Paris of numerous precision instrument manufacturers such as Charles Verdin, Otto Lund, Henri Collin, and Lucien Korsten, on whom Binet successively called in order to develop his projects in the field of experimental psychology. © 2016 Wiley Periodicals, Inc.

  16. Engaging with Lyell: Alfred Russel Wallace's Sarawak Law and Ternate papers as reactions to Charles Lyell's Principles of Geology.

    Science.gov (United States)

    Costa, J T

    2013-12-01

    Alfred Russel Wallace (1823-1913) and Charles Darwin (1809-1882) are honored as the founders of modern evolutionary biology. Accordingly, much attention has focused on their relationship, from their independent development of the principle of natural selection to the receipt by Darwin of Wallace's essay from Ternate in the spring of 1858, and the subsequent reading of the Wallace and Darwin papers at the Linnean Society on 1 July 1858. In the events of 1858 Wallace and Darwin are typically seen as central players, with Darwin's friends Charles Lyell (1797-1875) and Joseph Dalton Hooker (1817-1911) playing supporting roles. This narrative has resulted in an under-appreciation of a more central role for Charles Lyell as both Wallace's inspiration and foil. The extensive anti-transmutation arguments in Lyell's landmark Principles of Geology were taken as the definitive statement on the subject. Wallace, in his quest to solve the mystery of species origins, engaged with Lyell's arguments in his private field notebooks in a way that is concordant with his engagement with Lyell in the 1855 and 1858 papers. I show that Lyell was the object of Wallace's Sarawak Law and Ternate papers through a consideration of the circumstances that led Wallace to send his Ternate paper to Darwin, together with an analysis of the material that Wallace drew upon from the Principles. In this view Darwin was, ironically, intended for a supporting role in mediating Wallace's attempted dialog with Lyell.

  17. ‘What is ‘Czech’ in Art in Bohemia? Alfred Woltmann and defensive mechanisms of Czech artistic historiography’

    Directory of Open Access Journals (Sweden)

    Jindrich Vybiral

    2013-06-01

    Full Text Available The art historian Alfred Woltmann (1841-1880 in a lecture delivered 1876 put forth a highly provocative thesis on the predominance of the German element in the art of the Bohemian capital. He created thereby the outlines of a highly problematic situation, the resolution of which for many decades formed one of the central themes of Czech art history. Scholarly conclusions that proved the inferiority of the Slavonic tribe – and could not be simply disproved – consequently formed an insurmountable barrier for the efforts of Czech nationalist scholarship. Psychology makes use of the concept of “frustration” for such cases. Reactions to frustration are most commonly the defensive or ego-defensive mechanisms first mentioned in 1894 by Sigmund Freud and later described more fully by his daughter Anna Freud. The individual manifesting the symptom attempts to “destroy” the barrier or to attack the source of frustration in order to renew his or her psychic balance and repair his or her damaged self-evaluation. The essay aspires to make use of Freud´s systematic analysis to sketch an overview of the unconscious defensive mechanisms to be discerned in Czech artistic historiography following in the wake of Woltmann’s lecture (aggression, escape into fantasy, dismissal, repression, compensation, rationalisation, auto-accusation.

  18. Low dose radiotherapy as an effective treatment in a patient with solitary Wegener's granulomatosis resistant to systemic treatment – case report

    Science.gov (United States)

    Rutkowski, Tomasz; Składowski, Krzysztof; Hejduk, Beata

    2013-01-01

    Wegener's granulomatosis is a rare disease (10 per 1 000 000 new cases per year), etiologically connected with necrotizing vasculitis of small to medium-size vessels. The disease occurs predominantly in the upper respiratory tract, lungs and kidneys, but any organ may be affected during the course of the illness. It may be difficult to diagnose, especially when c-ACNA antibodies (serologic symptom of Wegener's granulomatosis) are undetectable and chest X-ray is normal. Early diagnosis is crucial for treatment results. Untreated disease may lead to death. Cyclophosphamide used simultaneously with prednisone is the treatment of choice as the first line procedure. Resistance to standard systemic treatment may be a significant problem. New drugs (rituximab, infliximab) are still under clinical investigation, with promising results. Very limited data concerning effectiveness of radiation therapy exist. We present a report of a female patient with solitary form of Wegener's granulomatosis located in the facial region, who underwent successful radiation therapy with a complete response. PMID:23788974

  19. Evaluation of the current fast neutron flux monitoring instrumentation applied to LFR demonstrator ALFRED. Capabilities and limitations

    International Nuclear Information System (INIS)

    Lepore, Luigi; Remetti, Romolo; Cappelli, Mauro

    2015-01-01

    Among Gen IV projects for future nuclear power plants, Lead Fast Reactors (LFR) seem to be a very interesting solution due to their benefits in terms of fuel cycle, coolant-safety and waste management. The novelty of the matter causes some open issues about coolant chemical aspect, structural aspects, monitoring instrumentation, etc. Particularly hard neutron flux spectra would make traditional neutron instrumentation unfit to all reactor conditions, i.e. source, intermediate, and power range. Identification of new models of nuclear instrumentation specialized for LFR neutron flux monitoring asks for an accurate evaluation of the environment the sensor will work in. In this study, thermal-hydraulics and chemical conditions for LFR core environment will be assumed, as the neutron flux will be studied extensively by means of the Monte Carlo transport code MCNPX. The core coolant’s high temperature drastically reduces the candidate instrumentation, because only some kind of fission chambers and Self Powered Neutron Detectors can be operated in such an environment. This work aims to evaluate the capabilities of the available instrumentation (usually designed for Sodium Fast Reactors, SFRs) when exposed to the neutron spectrum derived from ALFRED, a pool-type small-power LFR project to demonstrate the feasibility of this technology into the European framework. This paper shows that such instruments do follow the power evolution, but they are not completely suitable to detect the whole range of reactor power. Some improvements are then possible in order to increase the signal-to-noise ratio, by optimizing each instrument in the range of reactor power, such to get the best solution. Some new detector designs are here proposed, and the possibilities for prototyping and testing by means of a fast reactor investigated. (author)

  20. An existential criterion for normal and abnormal personality in the works of Sigmund Freud and Alfred Adler.

    Directory of Open Access Journals (Sweden)

    Kapustin S.A.

    2015-07-01

    Full Text Available This is the second in a series of four articles scheduled for publication in this journal. In the previous article I proposed a description of a new so-called existential criterion of normal and abnormal personality that is implicitly present in the works of Erich Fromm. According to this criterion, normal and abnormal personalities are determined, first, by special features of the content of their position regarding existential dichotomies that are natural to human beings and, second, by particular aspects of the formation of this position. Such dichotomies, entitatively existent in all human life, are inherent, two-alternative contradictions. The position of a normal personality in its content orients one toward a contradictious predetermination of life in the form of existential dichotomies and the necessity of searching for compromise in resolving these dichotomies. This position is created on a rational basis with the person’s active participation. The position of an abnormal personality in its content subjectively denies a contradictious predetermination of life in the form of existential dichotomies and orients one toward a consistent, noncompetitive, and, as a consequence, one-sided way of life that doesn’t include self-determination. This position is imposed by other people on an irrational basis. Abnormality of personality interpreted like that is one of the most important factors influencing the development of various kinds of psychological problems and mental disorders — primarily, neurosis. In this article I show that this criterion is implicitly present in the personality theories of Sigmund Freud and Alfred Adler, although in more special cases. In the following articles I will show that this criterion is also implicitly present in the personality theories of Carl Jung, Carl Rogers, and Viktor Frankl.

  1. The role of the medical examiner in mass casualty situations with special reference to the Alfred P. Murrah Building bombing.

    Science.gov (United States)

    Jordan, F B

    1999-04-01

    To describe the events that shaped the investigation by the Oklahoma Office of the Chief Medical Examiner with regard to the terrorist bombing of the Alfred P. Murrah Federal Building in Oklahoma City in 1995 and to provide lessons learned for reinforcement and future planning. All persons known to have been killed by the blast. Standard forensic techniques with regard to crime scene investigation, documentation, body identification and cause of death determinations were followed. Fatality injury and related evidence documentation. A total of 168 people died principally from secondary and tertiary injuries caused by projectiles, victim displacement, and crushing. Emphasis is placed on the methods of operation required to find, remove, identify, and determine cause of death in these individuals. Simultaneously, evidence must be identified and preserved in a homicide investigation of this type. Close cooperation must exist among multiple varied agencies and disciplines to accomplish the task and to prepare for subsequent analysis and courtroom testimony required by the criminal justice system. Terrorism, both foreign and domestic, is a current fact and will be a problem in many forms in the 21st century. No one is immune. The key to success is to plan ahead and be aware of available resources. Preplanning for short comings and difficult issues, and most importantly, relying on team work will allow future participants to successfully meet and complete the challenge. The investigation developed detailed injury data and mechanisms that were available for subsequent judicial proceedings and for in-depth epidemiological studies spearheaded by the Injury Prevention Service of the Oklahoma State Department of Health.

  2. [Alfred Marcin Sokołowski and Władyslaw Matlakowski. Contribution to history of spa treatment of pulmonary tuberculosis].

    Science.gov (United States)

    Kierzek, Andrzej; Pozowski, Andrzej; Kuciel-Lewandowska, Jadwiga

    2007-01-01

    The professional, scientific and didactic careers of Alfred Marcin Sokołowski (1849-1924) and Władysław Matlakowski (1851-1895) are presented at the beginning. Sokołowski was an assistant and afterwards a deputy of the head of hospital department Herman Brehmer in health resort in Goerbersdorf. In 1880 Sokołowski organized the internal diseases ward and rhinolaryngological outpatient clinic at St. Spirit Hospital in Warsaw. Sokołowski published "Clinical lectures of diseases of respiratory tract" (1902-1906) and many scientific papers. He was a pioneer of Polish pulmonology, rhinolaryngology and spa treatment of respiratory tract diseases. He was a well-known social worker. Matlakowski, who was a surgeon of Surgical Clinic of Warsaw Emperor University and an assistant of Julian Kosiński specialized in abdominal surgery and gynaecologic surgery. While suffering from pulmonary tuberculosis he moved to Zakopane, where he became famous as an ethnographer, an author of two books: "Country architecture of the Tatra Highlands" and "Decoration and equipment of Polish people of the Tatra Highlands". He translated Shakespearian "Hamlet" into Polish. He was also a well-known philosopher and an ornithologist. The meeting of Sokołowski and Matlakowski in Goerbersdorf, and also their further acquaintance and friendship are described widely by the author. Their work at "Gazeta Lekarska" ("Medical Magazine's") editorial office, which was well-known in three sectors of partitioned Poland is presented with more details by the author. Finally the epitome of spa treatment of pulmonary tuberculosis is presented. Sokołowski and Matlakowski were propagators of spa treatment of pulmonary tuberculosis; Sokołowski made Goerbersdorf famous, Matlakowski did the same for Zakopane.

  3. Distinct proteinase 3-induced cytokine patterns in Wegener´s granulomatosis, Churg-Strauss syndrome, and healthy controls.

    Science.gov (United States)

    Fagin, Ursula; Csernok, Elena; Müller, Antje; Pitann, Silke; Fazio, Juliane; Krause, Kristina; Bremer, Philip; Wipfler-Freissmuth, Edith; Moosig, Frank; Gross, Wolfgang L; Lamprecht, Peter

    2011-01-01

    To analyse whether a specific cytokine pattern is elicited in response to the autoantigen proteinase 3 (PR3) in active Wegener's granulomatosis (WG). Six-colour flow cytometry was used to analyse cytokine production and surface markers of the total CD4+ T-cell population ex vivo and in PR3-stimulated T-cell lines of patients with active PR3-ANCA-positive WG, PR3-ANCA-negative Churg-Strauss syndrome (CSS), and healthy controls (HC). The cytokine response of the total PB CD4+ T cell population was skewed towards distinct pro-inflammatory cytokine patterns in WG (Th1-type) and CSS (Th17, Th1-/Th2-type). Th2-type as well as Th17 cell populations including Th17/Th1, Th17/Th2 and Th22 cells were elicited in response to PR3 stimulation in WG. In contrast, CSS patients displayed a Th2-type dominated response following PR3 stimulation. These data suggest that the cytokine response of the total CD4+ T-cell population and PR3-specific cells is influenced by the underlying disorder.

  4. Malignant Pyoderma Associated with Granulomatosis with Polyangiitis (Wegener Granulomatosis) as a Unique Indication for Facial Vascularized Composite Allotransplantation: Part I.

    Science.gov (United States)

    Gastman, Brian; Hashem, Ahmed M; Djohan, Risal; Bernard, Steven; Hendrickson, Mark; Schwarz, Graham; Gharb, Bahar B; Rampazzo, Antonio; Fernandez, Anthony; Zins, James; Hoffman, Gary S; Doumit, Gaby; Siemionow, Maria; Papay, Francis

    2016-06-01

    Granulomatosis with polyangiitis (Wegener granulomatosis) is a rare disease that commonly starts in the craniofacial region and can lead to considerable facial disfigurement. Granulomas and vasculitis, however, can involve many other tissues (especially pulmonary and renal). Dermatologic and subcutaneous components can lead to malignant pyoderma. The authors describe a unique pathologic condition, where significant Le Fort type trauma was associated with subsequent development of granulomatosis with polyangiitis and malignant pyoderma. Successive operations to excise necrotic tissue and reconstruct the defects were followed by worsening inflammation and tissue erosions. Trauma and surgery in proximity to the eye and sinuses masked the initial clinical presentation and led to delay in diagnosis and disease progression. The resultant facial disfigurement and tissue loss were substantial. Despite multiple confounding factors, accurate diagnosis was eventually established. This was based on persistence of sinus inflammations in the absence of infective agents, proven sterility of lung lesions, and antineutrophil cytoplasmic antibody positivity with proteinase 3 specificity. Skin lesion biopsy specimens were identified as pyoderma gangrenosum and later as malignant pyoderma. Institution of immunosuppressive therapy allowed successful control of the disease and wound healing. The resulting craniofacial destruction, however, necessitated facial vascularized composite allotransplantation. Recognition of this rare pathologic association is essential, to prevent delays in diagnosis and treatment that can lead to major craniofacial tissue loss. Therapeutic, V.

  5. Epidemiology and etiology of wegener granulomatosis, microscopic polyangiitis, churg-strauss syndrome and goodpasture syndrome: vasculitides with frequent lung involvement.

    Science.gov (United States)

    Gibelin, Aude; Maldini, Carla; Mahr, Alfred

    2011-06-01

    This review focuses on the epidemiological characteristics and etiologies of four primary systemic vasculitides with frequent lung involvement, namely Wegener granulomatosis (WG), microscopic polyangiitis (MPA), Churg-Strauss syndrome (CSS), and Goodpasture syndrome (GPS). Elucidation of the mechanisms underlying these vasculitides with frequent lung involvement is complicated by their rarity, which hampers the undertaking of large-scale studies; difficulties in classification; and their multifaceted clinical presentations, which infer the existence of several etiologic pathways. Notwithstanding, epidemiological research showed some evidence for international, interethnic, and temporal variations of the frequencies of these four vasculitides; led to the identification of several genetic and environmental risk factors; and provided insight on the extent to which genes and environment might contribute to their development. Available data support the concept that WG, MPA, CSS, and GPS have unique and shared risk determinants. Although the precise causes of these vasculitides are not yet fully understood and the development of prevention strategies is out of our reach at present, current knowledge enables the formulation of etiologic hypotheses to provide caregivers and their patients with valuable information on the nature of these rare entities. © Thieme Medical Publishers.

  6. O monismo de primazia internacional: a proposta de Alfred Verdross para a relação entre direito internacional e direito estatal

    OpenAIRE

    Guimarães Nóbrega, Beatrice

    2009-01-01

    A relação entre direito internacional e direito estatal corresponde a uma das questões freqüentemente presentes nos estudos do direito internacional. Por isso, diversas foram as propostas apresentadas por juristas, internacionalistas ou não, acerca de tal relação. Proposta como a do internacionalista Alfred Verdross, o qual explica a relação que ocorre entre direito internacional e direito estatal por meio da Teoria Monista de primazia do direito internacional, a qual será objeto do presente ...

  7. [From Swiss herbs to the global plant system and individual use--a biographic approach to Alfred Vogel].

    Science.gov (United States)

    Melzer, J

    2003-04-01

    Even 100 years after the birth of Alfred Vogel there is a lack of reliable data about his life as a non-doctoral therapist in the fields of naturopathy and phytotherapy. Which documents about A. Vogel do exist, which facts do they prove about his career and which interpretations of his point of view of phytotherapy do they allow. With the methods in medical history (heuristic, critic, interpretation) video, audio and written documents from the A. Vogel Museum and A. Vogel publisher in Teufen, the A. Vogel collection in the Museum in Aesch and the Bioforce AG in Roggwil have been examined. From 1923 to 1932 A. Vogel runs a grocer's shop or a herb and health-food store in Basel and later Bern, Zürich and Solothurn. The economic success of his health-food stores and his interest in the field of naturopathy enable him to take part in a training to become a 'natural doctor' and in 1933 he is registered by the 'Natural Doctors Association of Switzerland'. From 1935 on he is working as a nutritionalist in his own spa pension in Trogen and produces plant extracts in his 'Laboratory Bioforce'. From 1937 to 1957 he has a spa hotel in Teufen and is producer of extracts from fresh plants. He is able to travel all continents of the world from 1958 on, in order to observe customs and medical habits of different tribes. He writes about his findings in his own magazine and books. His knowledge about the usage of herbs in different cultures inspires his production of herbal extracts in his company. In 1963, to meet the increasing sales of his products, he founds the where he, until the early 1990s, takes part in the adjustment of the recipes to the new pharmaceutic-medical standards. Because of his work as a 'natural doctor' A. Vogel becomes one of Switzerland's best known non-doctoral therapists in the 20th century. The publication of his collected wisdom in a lay-like language is a contribution to the tradition and popularity in this field through which, as well as through the

  8. Lesões destrutivas da linha média induzidas por cocaína com ANCA positivo mimetizando a granulomatose de Wegener Cocaine-induced midline destruction lesions with positive ANCA test mimicking Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    Letícia Stahelin

    2012-06-01

    Full Text Available O uso crônico de cocaína por inalação pode causar lesões destrutivas de linha média (LDLMIC, que podem ser difíceis de distinguir das lesões da granulomatose de Wegener (GW nos ouvidos, nariz e garganta. Descrevemos o caso de uma paciente de 43 anos admitida com história de dois anos de obstrução nasal e rinorreia. Ela havia recebido o diagnóstico de GW há cinco meses e estava em tratamento com prednisona e ciclofosfamida. Ao exame físico apresentava perfuração de septo nasal e palato. Exames de laboratório mostraram elevação das proteínas de fase aguda e teste p-ANCA positivo. Ensaios ELISA antiproteinase 3 e mieloperoxidase foram negativos. Tomografia computadorizada (TC dos seios paranasais mostrou destruição de septo nasal e palato, bem como sinusite maxilar bilateral. TC de tórax resultou normal. Biópsia da mucosa nasal revelou infiltrado inflamatório sem granuloma ou vasculite. Quando questionada, admitiu ser usuária de cocaína há cinco anos. Os imunossupressores foram suspensos e a paciente não mais fez uso da droga. Ela está sendo monitorada há seis meses e não desenvolveu novas lesões ou sintomas de outros órgãos. O diagnóstico diferencial em pacientes com LDLMIC pode ser desafiador. A avaliação deve incluir pesquisa de uso intranasal de cocaína. Embora o teste de ANCA não diferencie claramente o ANCA encontrado em alguns pacientes com LDLMIC daqueles em pacientes com GW, o envolvimento localizado e os achados de biópsia não típicos de vasculite granulomatosa de pequenos vasos devem ser reconhecidos como características das lesões induzidas por cocaína.Chronic use of cocaine by inhalation may induce midline destructive lesions (CIMDL, which can sometimes be difficult to distinguish from the ear, nose and throat lesions of Wegener's Granulomatosis (WG. We describe the case of a 43-year-old female patient admitted with a two-year history of nasal obstruction and rhinorrhea. She had been

  9. Early extracorporeal life support as rescue for Wegener granulomatosis with diffuse alveolar hemorrhage and acute respiratory distress syndrome: a case report and literature review.

    Science.gov (United States)

    Joseph, Mark; Charles, Anthony G

    2011-12-01

    The study's objective was to report a case and review the literature on the use of extracorporeal life support in the face of severe pulmonary hemorrhage for acute respiratory distress syndrome. This study is a single case report of a pediatric patient who was successfully managed on venovenous extracorporeal life support for severe acute respiratory distress syndrome with acute pulmonary hemorrhage secondary to Wegener disease. Extracorporeal life support can be used successfully in selected patients with respiratory failure with pulmonary hemorrhage. The cautious use of anticoagulation should be balanced with the risk of bleeding, mindful of the need for other measures to mitigate severe bleeding if this should occur.

  10. Alfred Loisy, más allá del ruido y del humo. «Qui perdiderit animan suam salvam faciet eam (Marc, VIII, 35

    Directory of Open Access Journals (Sweden)

    Robles Muñoz, Cristobal

    2007-12-01

    Full Text Available Loisy and the modernism were identified during years. This work tries, beyond the noise and the smoke, to contribute not to loose in the forgetfulness neither the person nor the reasons of Alfred Loisy, one of the most affected by the modernist crisis. We have resorted mainly to his Mémoires. Loisy did not need to hope years to receive the tribute that deserves a person who has not betrayed itself.Loisy y el modernismo se identicaron durante años. Este trabajo pretende, más allá del ruido y del humo, contribuir a que no se pierda en el olvido ni la persona ni las razones de Alfred Loisy, uno de los más afectados por la crisis modernista. Hemos recurrido sobre todo a a sus Mémoires. Loisy no necesitó esperar años para recibir el homenaje que merece una persona que no se ha traicionado.

  11. LAS CIUDADES EN EL CINE DE ALFRED HITCHCOCK. UNA APROXIMACIÓN A LOS ESTUDIOS FÍLMICOS DESDE EL AMBITO DE LA GEOGRAFÍA

    Directory of Open Access Journals (Sweden)

    Aurelio Nieto Codina

    2015-01-01

    Full Text Available En este artículo se proponen pautas en relación a la influencia de lo audiovisual en nuestra percepción de la ciudad, seleccionando para este objetivo algunas películas de Alfred Hitchcock. La relación del cineasta con la ciudad es ambivalente, unas veces muestra la ciudad como fuente de referencias emblemáticas, mientras en otros casos no duda en estigmatizar la ciudad tradicional compacta (centros urbanos tradicionales y apostar por modelos de urbanismo extensivo (periferias urbanas. Se describe también una nueva forma de turismo urbano, que explota los escenarios que aparecen en las películas como recurso turístico.Abstract. In this paper we propose guidelines regarding the influence of the audiovisual in our perception of the city, selecting for this purpose some of Alfred Hitchcock´s movies. The filmmaker's relationship with the city is ambivalent, sometimes shows the city as a source of symbolic references, while in other cases does not hesitate to stigmatize traditional compact city (downtowns and go for extensive planning models (suburb. It also describes a new form of urban tourism that exploits the scenarios that appear in movies as a tourism resource.

  12. Quality aspects of the Wegener Center multi-satellite GPS radio occultation record OPSv5.6

    Science.gov (United States)

    Angerer, Barbara; Ladstädter, Florian; Scherllin-Pirscher, Barbara; Schwärz, Marc; Steiner, Andrea K.; Foelsche, Ulrich; Kirchengast, Gottfried

    2017-12-01

    The demand for high-quality atmospheric data records, which are applicable in climate studies, is undisputed. Using such records requires knowledge of the quality and the specific characteristics of all contained data sources. The latest version of the Wegener Center (WEGC) multi-satellite Global Positioning System (GPS) radio occultation (RO) record, OPSv5.6, provides globally distributed upper-air satellite data of high quality, usable for climate and other high-accuracy applications. The GPS RO technique has been deployed in several satellite missions since 2001. Consistency among data from these missions is essential to create a homogeneous long-term multi-satellite climate record. In order to enable a qualified usage of the WEGC OPSv5.6 data set we performed a detailed analysis of satellite-dependent quality aspects from 2001 to 2017. We present the impact of the OPSv5.6 quality control on the processed data and reveal time-dependent and satellite-specific quality characteristics. The highest quality data are found for MetOp (Meteorological Operational satellite) and GRACE (Gravity Recovery and Climate Experiment). Data from FORMOSAT-3/COSMIC (Formosa Satellite mission-3/Constellation Observing System for Meteorology, Ionosphere, and Climate) are also of high quality. However, comparatively large day-to-day variations and satellite-dependent irregularities need to be taken into account when using these data. We validate the consistency among the various satellite missions by calculating monthly mean temperature deviations from the multi-satellite mean, including a correction for the different sampling characteristics. The results are highly consistent in the altitude range from 8 to 25 km, with mean temperature deviations less than 0.1 K. At higher altitudes the OPSv5.6 RO temperature record is increasingly influenced by the characteristics of the bending angle initialization, with the amount of impact depending on the receiver quality.

  13. Antimicrobial peptides in nasal secretion and mucosa with respect to S. aureus colonisation in Wegener´s granulomatosis.

    Science.gov (United States)

    Hui, Yuan; Wohlers, Janet; Podschun, Rainer; Hedderich, Jürgen; Lamprecht, Peter; Ambrosch, Petra; Laudien, Martin

    2011-01-01

    Nasal S. aureus carrier rates are significantly higher in patients with Wegener's granulomatosis (WG) compared to healthy controls (HC), and nasal colonisation is a risk-factor for relapse. Antimicrobial peptides (AMP) are important defence molecules maintaining an intact barrier function. It is the aim of this study to see if there is a possible link between the nasal AMP pattern and S. aureus colonisation, a link which has not been investigated so far. ELISA was applied to quantify LL-37 and hBD-3 concentrations in nasal secretions (14 WG patients, 13 HC) with and without nasal S. aureus colonisation. Immunohistochemistry was used to detect the cellular sources of AMP in the nasal mucosa. Functional analyses of primary nasal epithelial cell cultures (NEC) of these groups stimulated with S. aureus were performed. LL-37 was found in significantly higher concentrations in colonised individuals (WG: p=0.001; HC: p=0.014).Using immunohistochemistry, local cellular sources for AMP could be demonstrated. After stimulation with S. aureus, significantly higher concentrations of LL-37 and hBD-3 could be detected in the supernatant of NEC of WG patients (LL-37: p=0.001; hBD-3: p=0.001) and HC (LL-37: p=0.019; hBD-3: p=0.001). HBD-3 concentrations were significantly lower in the supernatant of stimulated NEC of WG patients compared to the NEC of HC (p=0.032), and the dynamic range of the hBD-3 answer was significantly smaller in WG compared to HC (p=0.016). The dynamic response towards challenges with microbes is dysregulated in WG, and this might be one reason for higher S. aureus colonisation rates in WG.

  14. Active disease and residual damage in treated Wegener's granulomatosis: an observational study using pulmonary high-resolution computed tomography

    International Nuclear Information System (INIS)

    Komocsi, Andras; Reuter, Michael; Heller, Martin; Murakoezi, Henriette; Gross, Wolfgang L.; Schnabel, Armin

    2003-01-01

    The purpose of this study was to determine to what extent high-resolution computed tomography (HRCT) of the lungs can distinguish active inflammatory disease from inactive cicatricial disease in patients treated for Wegener's granulomatosis (WG). Twenty-eight WG patients with active pulmonary disease underwent a first HRCT examination immediately before standard immunosuppressive treatment and a second examination after clinical remission had been achieved. Lesions remaining after treatment were categorized as residual damage and were compared with findings during active disease to see by what features active and cicatricial disease can be distinguished. During active disease 17 patients had nodules/masses, 12 had ground-glass opacities, 6 had septal lines and 6 had non-septal lines. After treatment, ground-glass opacities had resolved completely. Nodules/masses had resolved in 8 patients and had diminished in 7 patients. Residual nodules were distinguished from nodules/masses in active disease by lack of cavitation and a diameter of mostly <15 mm. In one-third of patients lines resolved, but in 8 instances new lines evolved during immunosuppression. During a follow-up period of a median 26.5 months (range 20.0-33.8), patients with residual nodules or lines had no more relapses than patients with completely cleared lungs. Treated pulmonary WG leaves substantial residual damage. High-resolution CT does assist in the distinction between active and inactive lesions. Ground-glass opacities, cavitating nodules/masses and masses measuring more than 3 cm represent active disease ordinarily. Non-cavitary small nodules and septal or non-septal lines can be either active or cicatricial lesions. The nature of these lesions needs to be clarified by longitudinal observation. (orig.)

  15. Evaluation of GPM IMERG Early, Late, and Final rainfall estimates using WegenerNet gauge data in southeastern Austria

    Science.gov (United States)

    O, Sungmin; Foelsche, Ulrich; Kirchengast, Gottfried; Fuchsberger, Juergen; Tan, Jackson; Petersen, Walter A.

    2017-12-01

    The Global Precipitation Measurement (GPM) Integrated Multi-satellite Retrievals for GPM (IMERG) products provide quasi-global (60° N-60° S) precipitation estimates, beginning March 2014, from the combined use of passive microwave (PMW) and infrared (IR) satellites comprising the GPM constellation. The IMERG products are available in the form of near-real-time data, i.e., IMERG Early and Late, and in the form of post-real-time research data, i.e., IMERG Final, after monthly rain gauge analysis is received and taken into account. In this study, IMERG version 3 Early, Late, and Final (IMERG-E,IMERG-L, and IMERG-F) half-hourly rainfall estimates are compared with gauge-based gridded rainfall data from the WegenerNet Feldbach region (WEGN) high-density climate station network in southeastern Austria. The comparison is conducted over two IMERG 0.1° × 0.1° grid cells, entirely covered by 40 and 39 WEGN stations each, using data from the extended summer season (April-October) for the first two years of the GPM mission. The entire data are divided into two rainfall intensity ranges (low and high) and two seasons (warm and hot), and we evaluate the performance of IMERG, using both statistical and graphical methods. Results show that IMERG-F rainfall estimates are in the best overall agreement with the WEGN data, followed by IMERG-L and IMERG-E estimates, particularly for the hot season. We also illustrate, through rainfall event cases, how insufficient PMW sources and errors in motion vectors can lead to wide discrepancies in the IMERG estimates. Finally, by applying the method of Villarini and Krajewski (2007), we find that IMERG-F half-hourly rainfall estimates can be regarded as a 25 min gauge accumulation, with an offset of +40 min relative to its nominal time.

  16. Local-level ground valuation of rainfall estimates by GPM IMERG Final run using the WegenerNet high-resolution precipitation data

    Science.gov (United States)

    Oh, Sungmin; Foelsche, Ulrich; Fuchsberger, Jürgen; Kirchengast, Gottfried

    2017-04-01

    We first performed a study on evaluation of Integrated Multi-Satellite Retrievals for Global Precipitation Measurement (IMERG) Early, Late, and Final rainfall estimates. Afterwards we proceeded to use the WegenerNet gridded precipitation data for detailed analysis of the performance of IMERG Final run data. In this current work, IMERG Final run estimates during the period from April to October for 3 years (2014-2016) are assessed with focus put on various parameters affecting the satellite rainfall retrieval techniques, for example, IR/PMW sensor data involved and seasonal rainfall variations or spatial variability. The WegenerNet gridded data (on a 200 m x 200 m grid, updated every 5-min) are generated from 1km-scale gauge measurements of its 151 weather stations through an Inverse Distance Weighted interpolation method. Given that the network is located within an area of about 15 km × 20 km (centered at 46.93 ˚ N/15.90 ˚ E in south-eastern Austria), two 0.1˚ x 0.1˚ IMERG grid cells can be selected for a direct pixel-to-pixel validation of IMERG data. This presentation will summarize the first study evaluating the three different IMERG runs with updated IMERG data (v4) and then show the results from the current study focusing on the IMERG Final run data.

  17. The Origin of Continents and Oceans : A. Wegener (translated by J. Biram from the 4th revised German edition, 1929) Dover, New York N.Y., 1966, 246 pp., 63 illus., paperbound U.S.$2.00

    NARCIS (Netherlands)

    Bemmelen, R.W. van

    In the old controversy between fixism and mobilism a new scientific tool, palaeomagnetism, has recently brought forward independent diagnostic facts. In the discussions about drift many authors quote Wegener's classic work. It is fortunate that it has now appeared in an excellent English translation

  18. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation

    DEFF Research Database (Denmark)

    Ruperto, Nicolino; Ozen, Seza; Pistorio, Angela

    2010-01-01

    To report methodology and overall clinical, laboratory and radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) classification criteria....

  19. Evaluation of GPM IMERG Early, Late, and Final rainfall estimates using WegenerNet gauge data in southeastern Austria

    Directory of Open Access Journals (Sweden)

    S. O

    2017-12-01

    Full Text Available The Global Precipitation Measurement (GPM Integrated Multi-satellite Retrievals for GPM (IMERG products provide quasi-global (60° N–60° S precipitation estimates, beginning March 2014, from the combined use of passive microwave (PMW and infrared (IR satellites comprising the GPM constellation. The IMERG products are available in the form of near-real-time data, i.e., IMERG Early and Late, and in the form of post-real-time research data, i.e., IMERG Final, after monthly rain gauge analysis is received and taken into account. In this study, IMERG version 3 Early, Late, and Final (IMERG-E,IMERG-L, and IMERG-F half-hourly rainfall estimates are compared with gauge-based gridded rainfall data from the WegenerNet Feldbach region (WEGN high-density climate station network in southeastern Austria. The comparison is conducted over two IMERG 0.1°  ×  0.1° grid cells, entirely covered by 40 and 39 WEGN stations each, using data from the extended summer season (April–October for the first two years of the GPM mission. The entire data are divided into two rainfall intensity ranges (low and high and two seasons (warm and hot, and we evaluate the performance of IMERG, using both statistical and graphical methods. Results show that IMERG-F rainfall estimates are in the best overall agreement with the WEGN data, followed by IMERG-L and IMERG-E estimates, particularly for the hot season. We also illustrate, through rainfall event cases, how insufficient PMW sources and errors in motion vectors can lead to wide discrepancies in the IMERG estimates. Finally, by applying the method of Villarini and Krajewski (2007, we find that IMERG-F half-hourly rainfall estimates can be regarded as a 25 min gauge accumulation, with an offset of +40 min relative to its nominal time.

  20. Arbuscular mycorrhizal fungi induced differential Cd and P phytoavailability via intercropping of upland kangkong (Ipomoea aquatica Forsk.) with Alfred stonecrop (Sedum alfredii Hance): post-harvest study.

    Science.gov (United States)

    Hu, Junli; Li, Jintian; Wu, Fuyong; Wu, Shengchun; Ye, Zhihong; Lin, Xiangui; Wong, Ming Hung

    2013-12-01

    A post-harvest experiment was conducted further to our previous greenhouse pot study on upland kangkong (Ipomoea aquatica Forsk.) and Alfred stonecrop (Sedum alfredii Hance) intercropping system in Cd-contaminated soil inoculated with arbuscular mycorrhizal (AM) fungi. Previously, four treatments were established in the intercropping experiment, including monoculture of kangkong (control), intercropping with stonecrop (IS), and IS plus inoculation with Glomus caledonium (IS+Gc) or Glomus versiforme (IS+Gv). Both kangkong and stonecrop plants were harvested after growing for 8 weeks. Then, the tested soils were reclaimed for growing post-harvest kangkong for 6 weeks. In the post-harvest experiment, there were no significant differences between the IS and control treatments, except for a significantly decreased (ptreatment. Compared with IS, both IS+Gc and IS+Gv significantly decreased (ppost-harvest soils.

  1. La estructura temporal de la intervención en el Trabajo Social. Un enfoque desde la fenomenología de Alfred Schutz

    Directory of Open Access Journals (Sweden)

    Ramiro Rodríguez

    2011-01-01

    Full Text Available El artículo, aborda la intervención en el Trabajo Social, situándola entre una forma de acción que se constituye en fases temporales, cuya duración se da enteramente en el flujo de conciencia de los sujetos participantes. En este sentido, la intervención, tendría su génesis, en lo que Alfred Schütz llama objeto temporal inmanente, en virtud de un continuum de retenciones y protenciones, que conforman el horizonte de pasado y futuro de la acción, pero por otro lado, la intervención sería resultante de procesos de coexistencia y simultaneidad de dos conciencias, a partir de la puesta cara a cara entre el trabajador social y el otro, y la relación social nosotros que le es subsecuente.

  2. Woorden wikken en wegen

    NARCIS (Netherlands)

    Kraaij, W.

    2009-01-01

    Zoals eenieder zich nog wel de roes kan herinneren na de eindexamenuitslag van de middelbare school, zo heeft voor mij ook de eerste kennismaking met het world wide web een bijzondere indruk gemaakt. Het zal ergens in 1993 geweest zijn toen ik aan collega’s van het toenmalige Instituut voor Taal en

  3. Granulomatosis with Polyangiitis (Wegener's)

    Science.gov (United States)

    ... American College of Rheumatology Committee on Communications and Marketing. This information is provided for general education only. Individuals should consult a qualified health care provider for professional medical advice, diagnosis and treatment of a medical ...

  4. WATER TEMPERATURE and other data from POLARSTERN from 1985-02-25 to 1995-01-14 (NODC Accession 9500129)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The water depth and temperature data was collected from ship POLARSTERN by the Alfred-Wegener Institute (AWI), Bremenhaven, Germany. The data was collected from...

  5. An epifluorescence microscopy method for direct detection and enumeration of the fungilike marine protists, the thraustochytrids

    Digital Repository Service at National Institute of Oceanography (India)

    Raghukumar, S.; Schaumann, K.

    - rial, and M. Luecker and A. Krack for technical assistance. Contribution 556 from the Alfred-Wegener-Institute for Polar and Marine Research, Bremerhaven, Germany. advantages. All species may not grow on the substrates or nutrient media currently...

  6. La antropología, el arte y la vida de las cosas. Una aproximación desde "Art and Agency" de Alfred Gell

    Directory of Open Access Journals (Sweden)

    Sergio Martínez Luna

    2012-05-01

    Full Text Available El arte ha sido un concepto controvertido para la teoría antropológica desde sus inicios. La Antropología se situó a menudo entre el reconocimiento de la singularidad cultural de objetos y prácticas a los que no se podía calificar como artísticos sin caer en el etnocentrismo y el esfuerzo por componer marcos comparativos tan amplios como para incluir una variedad de prácticas humanas relativas a la experiencia estética. Para salir del espacio definido por esos dos discursos, Alfred Gell sugirió que la experiencia del arte tiene que ver con una especial forma de atribución de agencia a los objetos y las imágenes. Considerar este fenómeno puede ser el punto de partida para elaborar una genuina teoría antropológica del arte, construida sobre la especificidad de la disciplina y sus herramientas conceptuales. Tal enfoque plantea cuestiones acerca de la definición de los conceptos de agencia, personalidad y materialidad que comprometen a otras versiones del análisis y la crítica cultural.

  7. Resister's logic: the anti-vaccination arguments of Alfred Russel Wallace and their role in the debates over compulsory vaccination in England, 1870-1907.

    Science.gov (United States)

    Fichman, Martin; Keelan, Jennifer E

    2007-09-01

    In the 1880s, Alfred Russel Wallace, the celebrated co-discoverer of natural selection, launched himself into the centre of a politicised and polarised debate over the unpopular compulsory vaccination laws in England. Wallace never wavered in his belief that smallpox vaccination was useless and likely dangerous. Six years before his death, the anti-vaccinationists successfully secured a conscience clause that effectively dismantled the compulsory vaccination laws. Several other important Victorian scientists joined Wallace in the fight to repeal compulsory vaccination arguing that widely held views on the effectiveness of vaccination and evidence for immunity were inconclusive in the light of (then) contemporary standards of evidence. This article situates Wallace's anti-vaccination logic within the broader matrix of sociopolitical and cultural reform movements of the late Victorian era. Additionally it provides the first detailed analysis of his critique of vaccination science, in particular the role statistics played in his arguments. In this period, both pro-vaccinationists and anti-vaccinationists invested great efforts in collating and analysing statistical data sets that either supported or refuted the claims of vaccination's effectiveness. While each side presented 'controlled' case studies to support their assertions, without an unambiguous test to measure or demonstrate vaccination's effectiveness, the anti-vaccinationists continued to mount credible statistical critiques of vaccination science.

  8. Continuidade ou ruptura? Uma análise de alguns aspectos da filosofia social de John Stuart Mill, Alfred Marshall e John Maynard Keynes

    Directory of Open Access Journals (Sweden)

    LAURA VALLADÃO DE MATTOS

    2015-06-01

    Full Text Available O artigo argumenta que é possível se falar em uma 'tradição' no campo de filosofia social e econômica unindo as obras de J.S. Mill e Alfred Marshall e J.M. Keynes. Essa 'tradição' pode ser caracterizada pelas seguintes concepções: (a pela rejeição moral aos valores aquisitivos do capitalismo; (b pela visão de que o sistema capitalista seria incapaz de resolver de forma espontânea as questões das desigualdades de renda e riqueza e da pobreza; (c pela ideia de que, por uma questão de garantia de liberdade e da diversidade, além de por questões de eficiência econômica, dever-se-ia deixar a iniciativa individual agir livremente nas esferas em que é capaz de engendrar bons resultados, mas que o Estado deveria intervir, quando essa falha, atuando em benefício da coletividade; (d pela crença de que seria possível melhorar significativamente esse sistema por meio de mudanças pontuais e graduais.

  9. Using Remote Sensing and GIS Techniques to Detect Changes to the Prince Alfred Hamlet Conservation Area in the Western Cape, South Africa

    Science.gov (United States)

    Duncan, P.; Lewarne, M.

    2016-06-01

    Understanding and identifying the spatial-temporal changes in the natural environment is crucial for monitoring and evaluating conservation efforts, as well as understanding the impact of human activities on natural resources, informing responsible land management, and promoting better decision-making. Conservation areas are often under pressure from expanding farming and related industry, invasive alien vegetation, and an ever-increasing human settlement footprint. This study focuses on detecting changes to the Prince Alfred Hamlet commonage, near Ceres in the Cape Floral Kingdom. It was chosen for its high conservation value and significance as a critical water source area. The study area includes a fast-growing human settlement footprint in a highly productive farming landscape. There are conflicting development needs as well as risks to agricultural production, and both of these threaten the integrity of the ecosystems which supply underlying services to both demands on the land. Using a multi-disciplinary approach and high-resolution satellite imagery, land use and land cover changes can be detected and classified, and the results used to support the conservation of biodiversity and wildlife, and protect our natural resources. The aim of this research is to study the efficacy of using remote sensing and GIS techniques to detect changes to critical conservation areas where disturbances can be understood, and therefore better managed and mitigated before these areas are degraded beyond repair.

  10. USING REMOTE SENSING AND GIS TECHNIQUES TO DETECT CHANGES TO THE PRINCE ALFRED HAMLET CONSERVATION AREA IN THE WESTERN CAPE, SOUTH AFRICA

    Directory of Open Access Journals (Sweden)

    P. Duncan

    2016-06-01

    Full Text Available Understanding and identifying the spatial-temporal changes in the natural environment is crucial for monitoring and evaluating conservation efforts, as well as understanding the impact of human activities on natural resources, informing responsible land management, and promoting better decision-making. Conservation areas are often under pressure from expanding farming and related industry, invasive alien vegetation, and an ever-increasing human settlement footprint. This study focuses on detecting changes to the Prince Alfred Hamlet commonage, near Ceres in the Cape Floral Kingdom. It was chosen for its high conservation value and significance as a critical water source area. The study area includes a fast-growing human settlement footprint in a highly productive farming landscape. There are conflicting development needs as well as risks to agricultural production, and both of these threaten the integrity of the ecosystems which supply underlying services to both demands on the land. Using a multi-disciplinary approach and high-resolution satellite imagery, land use and land cover changes can be detected and classified, and the results used to support the conservation of biodiversity and wildlife, and protect our natural resources. The aim of this research is to study the efficacy of using remote sensing and GIS techniques to detect changes to critical conservation areas where disturbances can be understood, and therefore better managed and mitigated before these areas are degraded beyond repair.

  11. James Mark Baldwin with Alfred North Whitehead on Organic Selectivity: The “Novel” Factor in Evolution

    Directory of Open Access Journals (Sweden)

    Adam Christian Scarfe

    2009-11-01

    -ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

    The aim of this paper is to show how James Mark Baldwin’s theory of Organic Selection (also known as the “Baldwin effect” can be fruitfully integrated with Alfred North Whitehead’s speculative philosophy, as part of the endeavor to develop a comprehensive process-relational evolutionary cosmology. In so doing, it provides an overview of the theory of Organic Selection and points to several concrete examples from the Galapagos Islands which elucidate Baldwin’s claim that organisms, through their selective activities and behavioral adjustments, play a causal role in directing evolutionary processes. I emphasize some of the affinities between Baldwin’s theory of Organic Selection and Whitehead’s theory of prehensions, especially focusing on the latter’s notion of “prehensive selectivity.” Overall, while Baldwin’s theory of Organic Selection provides a biological ground for a comprehensive process-relational evolutionary cosmology to be developed, illuminating the importance of Whitehead’s theory of prehensions for evolutionary theory, Whitehead’s overall speculative scheme can, in turn, strengthen the metaphysical, epistemological, and ethical foundations of Baldwin’s theory. In the course of merging the two views, I arrive at an enlarged conception of Organic Selection, placing it in context with Darwin’s principle of Natural Selection. At the end of the paper, I take up the resulting question of the ethics of selectivity in general, arguing that the merger of Baldwin’s and Whitehead’s ideas constitutes a “non-reductionistic critical pan-selectionism.” This position stands in contrast to the antagonistic standpoints of “Selectionism” and

  12. Active disease and residual damage in treated Wegener's granulomatosis: an observational study using pulmonary high-resolution computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Komocsi, Andras [Poliklinik fuer Rheumatologie, Universitaet Luebeck, Ratzeburger Allee 160, 23538 Luebeck (Germany); Reuter, Michael; Heller, Martin [Klinik fuer Diagnostische Radiologische, Universitaet Kiel, Arnold-Heller-Strasse 7, 24105 Kiel (Germany); Murakoezi, Henriette; Gross, Wolfgang L.; Schnabel, Armin [Poliklinik fuer Rheumatologie, Universitaet Luebeck, Ratzeburger Allee 160, 23538 Luebeck (Germany); Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck (Germany)

    2003-01-01

    The purpose of this study was to determine to what extent high-resolution computed tomography (HRCT) of the lungs can distinguish active inflammatory disease from inactive cicatricial disease in patients treated for Wegener's granulomatosis (WG). Twenty-eight WG patients with active pulmonary disease underwent a first HRCT examination immediately before standard immunosuppressive treatment and a second examination after clinical remission had been achieved. Lesions remaining after treatment were categorized as residual damage and were compared with findings during active disease to see by what features active and cicatricial disease can be distinguished. During active disease 17 patients had nodules/masses, 12 had ground-glass opacities, 6 had septal lines and 6 had non-septal lines. After treatment, ground-glass opacities had resolved completely. Nodules/masses had resolved in 8 patients and had diminished in 7 patients. Residual nodules were distinguished from nodules/masses in active disease by lack of cavitation and a diameter of mostly <15 mm. In one-third of patients lines resolved, but in 8 instances new lines evolved during immunosuppression. During a follow-up period of a median 26.5 months (range 20.0-33.8), patients with residual nodules or lines had no more relapses than patients with completely cleared lungs. Treated pulmonary WG leaves substantial residual damage. High-resolution CT does assist in the distinction between active and inactive lesions. Ground-glass opacities, cavitating nodules/masses and masses measuring more than 3 cm represent active disease ordinarily. Non-cavitary small nodules and septal or non-septal lines can be either active or cicatricial lesions. The nature of these lesions needs to be clarified by longitudinal observation. (orig.)

  13. Alfred Nobel og hans priser

    DEFF Research Database (Denmark)

    Nielsen, Henry

    2017-01-01

    Siden 1901er der næsten hvert år blevet uddelt nobelpriser for fysik, kemi, fysiologi eller medicin, litteratur og fredsarbejde. Men hvad var det, der fik prisernes ophavsmand til at belønne netop disse fem felter? Og hvordan finder de ansvarlige i Stockholm og Oslo frem til årets prisvindere. De...

  14. Alfred Russel Wallace deserves better

    Indian Academy of Sciences (India)

    2010-06-30

    Jun 30, 2010 ... Like Darwin, he was a truly remarkable nineteenth century intellect and polymath and, according to a recent book by Roy Davies (The Darwin conspiracy: origins of a scientific crime), he has a stronger claim to the Theory of Evolution by Natural Selection than has Darwin. Here we present a critical ...

  15. Arbuscular mycorrhizal fungi enhance both absorption and stabilization of Cd by Alfred stonecrop (Sedum alfredii Hance) and perennial ryegrass (Lolium perenne L.) in a Cd-contaminated acidic soil.

    Science.gov (United States)

    Hu, Junli; Wu, Shengchun; Wu, Fuyong; Leung, Ho Man; Lin, Xiangui; Wong, Ming Hung

    2013-10-01

    A greenhouse pot experiment was conducted to compare the phytoextraction efficiencies of Cd by hyper-accumulating Alfred stonecrop (Sedum alfredii Hance) and fast-growing perennial ryegrass (Lolium perenne L.) from a Cd-contaminated (1.6 mg kg(-1)) acidic soil, and their responses to the inoculations of two arbuscular mycorrhizal (AM) fungal strains, Glomus caledonium 90036 (Gc) and Glomus mosseae M47V (Gm). Ryegrass and stonecrop were harvested after growing for 9 and 27 wk, respectively. Without AM fungal inoculation, the weekly Cd extraction by stonecrop (8.0 μg pot(-1)) was 4.3 times higher than that by ryegrass (1.5 μg pot(-1)). Both Gc and Gm significantly increased (P soil acid phosphatase activities, and available P concentrations, and thereby plant P absorptions (except for Gm-inoculated ryegrass), shoot biomasses, and Cd absorptions (except for Gm-inoculated stonecrop), while only Gc-inoculated stonecrop significantly accelerated (P soil pH. The results suggested the potential application of hyper-accumulating Alfred stonecrop associated with AM fungi (notably Gc) for both extraction and stabilization of Cd in the in situ treatment of Cd-contaminated acidic soil. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Characteristics and Outcomes of Granulomatosis With Polyangiitis (Wegener) and Microscopic Polyangiitis Requiring Renal Replacement Therapy: Results From the European Renal Association-European Dialysis and Transplant Association Registry.

    Science.gov (United States)

    Hruskova, Zdenka; Stel, Vianda S; Jayne, David; Aasarød, Knut; De Meester, Johan; Ekstrand, Agneta; Eller, Kathrin; Heaf, James G; Hoitsma, Andries; Martos Jimenéz, Carmen; Ravani, Pietro; Wanner, Christoph; Tesar, Vladimir; Jager, Kitty J

    2015-10-01

    This study describes the incidence and outcomes of European patients requiring renal replacement therapy (RRT) for kidney failure due to antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Cohort study. 12 renal registries providing individual RRT patient data to the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry in 1993-2012 participated. Cause of primary kidney disease: AAV (ie, granulomatosis with polyangiitis [Wegener] and microscopic polyangiitis) versus 3 separate matched control groups without AAV: (1) primary glomerulonephritis, (2) diabetes mellitus, and (3) disease other than diabetes mellitus as the cause of primary kidney disease, including glomerulonephritis (termed "nondiabetes"). Incidence, causes of death, and survival. ERA-EDTA primary renal disease codes. 2,511 patients with AAV (1,755, granulomatosis with polyangiitis; 756, microscopic polyangiitis) were identified, representing an incidence of 1.05 per million population (pmp) for granulomatosis with polyangiitis (predominating in Northern Europe) and 0.45 pmp for microscopic polyangiitis (prevailing in Southern Europe). Kidney transplantation was performed in 558 (22.2%) patients with vasculitis. The 10-year probability for survival on RRT after day 91 was 32.5% (95% CI, 29.9%-35.1%) in patients with vasculitis. Survival on RRT after day 91 did not differ between AAV and matched nondiabetes patients. Patient and transplant survival after kidney transplantation, adjusted for time period and country, was better in AAV than in matched nondiabetes patients (HRs of 0.81 [95% CI, 0.67-0.99] and 0.82 [95% CI, 0.69-0.96], respectively). No data for extrarenal manifestations, treatment, and relapses. Geographical differences in the incidence of RRT for kidney failure due to granulomatosis with polyangiitis and microscopic polyangiitis copied their distribution in the general population. Overall survival on RRT after day 91 for patients

  17. Mundo de la vida, comprensión y acción intersubjetiva en la sociología fenomenológica de Alfred Schütz.

    Directory of Open Access Journals (Sweden)

    Héctor Mora Nawrath

    2009-07-01

    Full Text Available El artículo elabora una aproximación descriptiva y analítica respecto de tres conceptos centrales en la propuesta de Alfred Schütz: ‘mundo de la vida’ (Lebenswelt, ‘comprensión’ (Verstehen y ‘acción intersubjetiva’. Explora el sentido del ‘mundo de la vida’ como realidad eminente, así como la multiformidad que éste adquiere desde la perspectiva del actor social; revisa el concepto de ‘comprensión’ en tanto capacidad del actor, como en su relación con la conformación del mundo social; y reflexiona respecto a las características que adquiere la acción social subjetiva e intersubjetiva, situándola en los marcos espaciotemporales.

  18. Prevalência das manifestações clínicas iniciais da granulomatose de Wegener no Brasil: relato de seis casos e revisão da literatura Wegener's granulomatosis: prevalence of the initial clinical manifestations - report of six cases and review of the literature

    Directory of Open Access Journals (Sweden)

    Carlos Ewerton Maia Rodrigues

    2010-04-01

    Full Text Available OBJETIVOS: Descrever as manifestações clínicas iniciais da Granulomatose de Wegener (GW diagnosticada no Brasil. PACIENTES E MÉTODOS: Análise retrospectiva de seis prontuários do Serviço de Reumatologia do Hospital Geral de Fortaleza (HGF, assim como a realização de um levantamento bibliográfico dos casos de GW descritos no Brasil obtidos dos bancos de dados LILACS, SciELO e MEDLINE. RESULTADOS: O estudo identificou 49 pacientes; 15 (31% do sexo masculino e 34 (69% do sexo feminino. A forma sistêmica ocorreu em 35 pacientes (73%: 28 adultos, cinco crianças e dois adolescentes. A doença limitada ocorreu em 13 adultos e uma criança. A média da idade adulta no início da doença foi de 42,2 anos (18 a 65 anos. O quadro clínico agudo, com sintomas há menos de três meses do diagnóstico, ocorreu em 41% (20/49 da casuística e a forma insidiosa, em 59% (29/49 dos pacientes. A prevalência das manifestações clínicas iniciais nos adultos com doença sistêmica (n = 28 foi 64% (18/28 das vias aéreas superiores (VAS, 36% (10/28 pulmonares, 18% (5/28 renais, 25% (7/28 oculares, 11% (3/28 cutâneas, 25% (7/28 musculoesqueléticas e 7% (2/28 neurológicas. Na forma limitada do adulto (n = 13, os sintomas prevalentes foram 84% (11/13 VAS, 23% (3/13 oculares e 15% (2/13 pulmonares. CONCLUSÃO: No Brasil, a prevalência das manifestações clínicas iniciais da GW foi semelhante aos resultados da literatura. A falta de especificidade dos sintomas pode retardar o diagnóstico na forma insidiosa da doença e aumentar a morbimortalidade das formas agudas.OBJECTIVES: To describe the initial clinical manifestations of Wegener's Granulomatosis (WG in Brazil. PATIENTS AND METHODS: Retrospective analysis of six medical records of WG patients followed-up at the Rheumatology Department of Hospital Geral of Fortaleza (HGF, as well as a bibliographic survey of cases of WG in Brazil on LILACS, SciELO, and MEDLINE databases. RESULTS: The study

  19. La modélisation de la face terrestre. Sur l'histoire des stratégies de modélisation de la dérive des continents

    OpenAIRE

    Grevsmühl, Sebastian

    2008-01-01

    International audience; Korrelierte Kontinente sind nicht die Erfindung Alfred Wegeners, wenngleich er dem Modell in »Die Entstehung der Kontinente« den Status einer Ikone der Moderne bereitet hat. Der Diskurs um die Korrelation beginnt schon im 16. Jahrhundert mit den ersten kartografischen Einschreibungen der kontinentalen Küstenlinien. Doch mit Wegeners umfassender »Verschiebungstheorie« erlangt die Figur der visuellen Korrelation eine erste, wenngleich umstrittene wissenschaftliche Fundie...

  20. Kinetic analysis of the blood clearance and organ uptake curves of IgG-coated red cells in HLA-typed controls and patients with Wegener's granulomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Woude, F.J. van der; Hauw The, T.; Beekhuis, H.; Beelen, J.M.

    1986-07-01

    Reticuloendothelial function and HLA type were studied in 22 controls and 15 patients with Wegener's granulomatosis (WG). IgG-coated red cells were injected intravenously and half-life of blood disappearance and liver spleen uptake curves were related to the degree of antibody coating. Erythrocytes with 13,990 molecules of IgG per cell gave biexponential blood disappearance curves and were suitable for measuring splenic reticuloendothelial function. Half-life times thus obtained were not significantly different for individuals with the HLA-DR2 or DR3 phenotype. In WG patients with major disease activity, blood clearance of the injected cells was considerably decreased. Kinetic analysis of blood disappearance and spleen uptake curves revealed that this was partly due to a decrease in reversible trapping of the cells in the spleen. This suggests that a blocking effect of circulating immune complexes on splenic Fc receptors is not likely to be the sole cause of the observed hyposplenism.

  1. A abordagem cognitiva da metáfora em perspectiva pragmática nos séculos dezoito e dezenove: as contribuições de Lambert e Wegener a discussões atuais

    Directory of Open Access Journals (Sweden)

    Ulrike Agathe Schröder

    2014-01-01

    Full Text Available Desde o surgimento da Teoria Conceptual da Metáfora, há mais de trinta anos, houve uma série de autores que apontaram a falta de contextualização historiográfica, uma vez que a maioria das hipóteses sobre a metáfora conceptual e até boa parte dos exemplos já são antecipadas desde o século dezessete em reflexões filosóficas, antropológicas, psicológicas e linguísticas. O presente trabalho pretende apresentar dois pensadores dos séculos dezoito e dezenove, a saber, o filósofo Johann Heinrich Lambert (1965 e o linguista Philipp Wegener (1991, que não apenas já desenvolvem uma teoria cognitiva da metáfora cotidiana, como também já conseguem integrar aspectos pragmáticos, que atualmente são redescobertos como fatores descuidados pela primeira geração da Linguística Cognitiva. Sendo assim, as duas concepções podem lançar uma ponte a discussões atuais, uma vez que ambas conseguem apontar caminhos para superar tanto o abismo entre o sujeito solipsista e a sociedade, como a dicotomia entre universalismo e relatividade cultural. Os dois autores entendem a metáfora como fenômeno cognitivo e, ao mesmo tempo, intersubjetivo, por ser negociado entre os participantes em situações comunicativas concretas.

  2. [Sigmund Freud's ambition and Alfred Adler].

    Science.gov (United States)

    Lebzeltern, G

    1984-11-09

    Freud never admitted to himself that he possessed a greater-than-average sense of ambition, which manifested itself in dreams, malachievement and priority problems. A completely new picture of Freud arises from such a perspective. Freud experienced childhood trauma in the form of his relationship with his nephew, John, in whom both an intimate friend and hated enemy were incorporated. This experience left a life-long impression which predetermined the neurotic element in Freud's relationship with men. Freud's own interpretation being that he had been betrayed by Breuer, Fliess, Adler and Jung. That is why the sentencing of his Uncle Joseph to a term of imprisonment had such far-reaching consequences for Freud. A further noteworthy observation is the close connection between ambition and death wishes and also between ambition and guilt feelings. Who, after all, likes to admit to harbouring such feelings? It appeared necessary to investigate the extent to which Freud's excessive ambition influenced his relationships with Breuer, Fliess and Adler. Freud was never prepared to recognize that Adler's contribution consisted of revealing the importance of the natural laws governing those layers of the psyche nearer to the conscious. The picture of the whole person emerges only by a combination of psychoanalysis and individual psychology.

  3. Alfred-Adler's Basic Concepts and Implications.

    Science.gov (United States)

    Lundin, Robert W.

    This book presents the basic principles of Adler's psychology. The first chapter looks at Adlerian psychology as it exists today, and examines earlier influences. The second chapter examines feelings of inferiority and compensation for these feelings. The third chapter considers the nature of goals and how they are formulated. The fourth chapter…

  4. Benzer Sektörde Faaliyet Gösteren Kurumların Kuruluş Tarihi Sıralamasının Kurum Kültüründe Ortaya Çıkan Yansımaları: Alfred Adler Üzerinden Coca Cola ve Pepsi Kurumları Üzerine Bir Değerlendirme

    OpenAIRE

    KARADOĞAN DORUK, Sevimece; SAVAŞ, Sezgin

    2017-01-01

    Çalışma, kurumların kuruluş sırası ile kurum kültürü oluşumunun bağlantısını Alfred Adler’in kavramsal yaklaşımı üzerinden ele alarak değerlendirmeyi amaçlamaktadır. Bu amaçtan hareketle çalışmanın ilk bölümünde Alfred Adler’in düşünsel pratiği ortaya konulurken, söz konusu araştırmacının özellikle doğum sırası sınıflandırması ve kompleks kavramına odaklanılmaktadır. Aynı doğrultuda ikinci bölümde de kurum kültürünün oluşumu ve bu oluşum sürecinde doğum sırası (kuruluş sırası) ve kompleksler...

  5. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    More Details Fulltext PDF. pp 35-42 General Article. X-ray Crystallography of Biological Macromolecules · K Suguna · More Details Fulltext PDF. pp 43-59 General Article. Alfred Wegener – From Continental Drift to Plate Tectonics · A J Saigeetha Ravinder Kumar Banyal · More Details Fulltext PDF. pp 60-69 General Article.

  6. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Ravinder Kumar Banyal. Articles written in Resonance – Journal of Science Education. Volume 10 Issue 6 June 2005 pp 43-59 General Article. Alfred Wegener – From Continental Drift to Plate Tectonics · A J Saigeetha Ravinder Kumar Banyal · More Details ...

  7. The dispersal-vicariance pendulum and butterfly biogeography

    Indian Academy of Sciences (India)

    concept of phylogeny unknown. Identification of centres-of-origin. Kodandaramaiah 2009. Evolutionary Biology. Page 13. Ratite (flightless) birds. Source: www.geo.arizona.edu. Photo: GD Rowley. Photo: David Bygott. Page 14. The Origin of Continents and Oceans -Alfred Wegener. 1915. Accepted in the 1960s. Page 15 ...

  8. AJ Saigeetha

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. A J Saigeetha. Articles written in Resonance – Journal of Science Education. Volume 10 Issue 6 June 2005 pp 43-59 General Article. Alfred Wegener – From Continental Drift to Plate Tectonics · A J Saigeetha Ravinder Kumar Banyal · More Details Fulltext PDF ...

  9. CryoSat-2 Validation using CryoVEX 2011-12 Airborne Campaigns

    DEFF Research Database (Denmark)

    Skourup, Henriette; Forsberg, René; Kildegaard Rose, Stine

    north of Alert and sea ice around Svalbard in the Fram Strait. Selected tracks were planned to match CryoSat-2 passes and a few of them were flown in formation flight with the Alfred Wegener Institute (AWI) Polar-5 carrying an EM-bird. This presentation summarizes the 2011-12 airborne campaigns...

  10. Frank Bursley Taylor - Forgotten Pioneer of Continental Drift.

    Science.gov (United States)

    Black, George W., Jr.

    1979-01-01

    Frank B. Taylor was an American geologist who specialized in the glacial geology of the Great Lakes. This article discusses his work on the Continental Drift theory, which preceeded the work of Alfred Wegener by a year and a half. (MA)

  11. Ravinder Kumar Banyal

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Ravinder Kumar Banyal. Articles written in Resonance – Journal of Science Education. Volume 10 Issue 6 June 2005 pp 43-59 General Article. Alfred Wegener – From Continental Drift to Plate Tectonics · A J Saigeetha Ravinder Kumar Banyal · More Details ...

  12. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 10; Issue 6. Alfred Wegener – From Continental Drift to Plate Tectonics. A J Saigeetha Ravinder Kumar Banyal. General Article Volume 10 Issue 6 June 2005 pp 43-59. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. Fulltext PDF

    Indian Academy of Sciences (India)

    In this issue, Resonance features that remarkable scientist, Alfred. Wegener, astronomer turned meteorologist. However ... and enjoy! The variety of articles in this issue of. Resonance is an affirmation of our philosophy that every student of science should find out about areas of science which may not be related to herown.

  14. Editorial

    Indian Academy of Sciences (India)

    the Bard 'Great lords, wise men ne'er sit and wail their loss, but cheerly seek how to redeem their harms' . In this issue, Resonance features that remarkable scientist, Alfred. Wegener, astronomer turned meteorologist. However, it was yet another science, geophysics, which brought him fame - he is justly given the credit for ...

  15. ESA CryoVEx 2011

    DEFF Research Database (Denmark)

    Skourup, Henriette; Barletta, Valentina Roberta; Einarsson, Indriði

    data obtained with an airborne electromagnetic (AEM) induction sounder conducted by Alfred Wegener Institute (AWI) with fixed‐wing airplane (Polar‐5, Basler BT‐67). DTU Space airborne team visited five main validation sites: Devon ice cap (Canada), Austfonna ice cap (Svalbard), the EGIG line crossing...

  16. Význam teorie kontinentálního driftu Alfreda Wegenera

    Czech Academy of Sciences Publication Activity Database

    Špičák, Aleš

    2012-01-01

    Roč. 55, č. 1 (2012), s. 3-6 ISSN 0300-4414 Institutional research plan: CEZ:AV0Z30120515 Institutional support: RVO:67985530 Keywords : Alfred Wegener * continental drift * plate tectonics * history of the Earth Sciences Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  17. A new numerical model for simulating the propagation of and inundation by tsunami waves

    NARCIS (Netherlands)

    Cui, H.

    2013-01-01

    This thesis has involved the development of an unstructured grid ocean model, H2Ocean, with accurate flooding and drying algorithms for tsunami studies. The research is co-funded by the Alfred Wegener Institute (AWI) in Bremerhaven, Germany, as part of their contribution to the German-Indonesian

  18. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria.

    Science.gov (United States)

    Ozen, Seza; Pistorio, Angela; Iusan, Silvia M; Bakkaloglu, Aysin; Herlin, Troels; Brik, Riva; Buoncompagni, Antonella; Lazar, Calin; Bilge, Ilmay; Uziel, Yosef; Rigante, Donato; Cantarini, Luca; Hilario, Maria Odete; Silva, Clovis A; Alegria, Mauricio; Norambuena, Ximena; Belot, Alexandre; Berkun, Yackov; Estrella, Amparo Ibanez; Olivieri, Alma Nunzia; Alpigiani, Maria Giannina; Rumba, Ingrida; Sztajnbok, Flavio; Tambic-Bukovac, Lana; Breda, Luciana; Al-Mayouf, Sulaiman; Mihaylova, Dimitrina; Chasnyk, Vyacheslav; Sengler, Claudia; Klein-Gitelman, Maria; Djeddi, Djamal; Nuno, Laura; Pruunsild, Chris; Brunner, Jurgen; Kondi, Anuela; Pagava, Karaman; Pederzoli, Silvia; Martini, Alberto; Ruperto, Nicolino

    2010-05-01

    To validate the previously proposed classification criteria for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA). Step 1: retrospective/prospective web-data collection for children with HSP, c-PAN, c-WG and c-TA with age at diagnosis

  19. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation.

    Science.gov (United States)

    Ruperto, Nicolino; Ozen, Seza; Pistorio, Angela; Dolezalova, Pavla; Brogan, Paul; Cabral, David A; Cuttica, Ruben; Khubchandani, Raju; Lovell, Daniel J; O'Neil, Kathleen M; Quartier, Pierre; Ravelli, Angelo; Iusan, Silvia M; Filocamo, Giovanni; Magalhães, Claudia Saad; Unsal, Erbil; Oliveira, Sheila; Bracaglia, Claudia; Bagga, Arvind; Stanevicha, Valda; Manzoni, Silvia Magni; Pratsidou, Polyxeni; Lepore, Loredana; Espada, Graciela; Kone-Paut, Isabella; Paut, Isabelle Kone; Zulian, Francesco; Barone, Patrizia; Bircan, Zelal; Maldonado, Maria del Rocio; Russo, Ricardo; Vilca, Iris; Tullus, Kjell; Cimaz, Rolando; Horneff, Gerd; Anton, Jordi; Garay, Stella; Nielsen, Susan; Barbano, Giancarlo; Martini, Alberto

    2010-05-01

    To report methodology and overall clinical, laboratory and radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) classification criteria. The preliminary Vienna 2005 consensus conference, which proposed preliminary criteria for paediatric vasculitides, was followed by a EULAR/PRINTO/PRES - supported validation project divided into three main steps. Step 1: retrospective/prospective web-data collection for HSP, c-PAN, c-WG and c-TA, with age at diagnosis

  20. Lothar de Maizière: Stasil on praegu rohkemgi võimu kui Saksa DV ajal / Lothar de Maizière ; intervjueerinud Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Maizière, Lothar de

    2009-01-01

    Intervjuu Saksa DV esimese ja ühtlasi viimase demokraatlikult valitud peaministriga Berliini müüri langemisest 20 aastat tagasi, 21. sajandi peamistest väljakutsetest. SDV ajaloo uurimisest läänesakslaste poolt, ajaloo läbitöötamise käigus sündinud vildakast pildist SDV ühiskonnast, Stasi toimikutest

  1. Postmarketing study of efficacy and safety of losartan during the treatment of patients with mild and moderate hypertension: Lothar study

    Directory of Open Access Journals (Sweden)

    Vasiljević Zorana

    2013-01-01

    Full Text Available Introduction. Losartan, the angiotensin type 1 receptor blocker (ARB exercises its main antihypertensive effect by vasodilatation of peripheral arteries. Objective. The aim of this study was to evaluate the antihypertensive effect and safety of losartan in patients with mild and moderate arterial hypertension (AH. Methods. This was an open post-marketing study with losartan as monotherapy in previously treated or untreated patients with AH. Primary efficacy parameter was the percentage of patients that achieved target blood pressure after 8-week treatment with a single daily dose of losartan of 50-100 mg. Safety parameters were assessed according to the percentage of adverse events and metabolic effects of therapy. Results. The study included 550 patients with AH (59% female and 41% male, mean age 56.8±11.4 years, BMI=27±4 kg/m2. Losartan was applied in 31% of untreated and 69% of previously treatment-resistant patients After 8 weeks target blood pressure was achieved in 67.8% (SBP and in 81.1% (DBP of patients, respectively. The mean decrease was 21.8% for SBP and 21.1% for DBP (p<0.001. Out of all, 65% of patients achieved both target SBP and DBP values. Hydrochlorothiazide was added to the therapy in 11.6% of patients. There were no significant differences in drug efficacy between the entire group and subgroups of patients with diabetes mellitus and impaired renal function (p=ns. Adverse events were rare and metabolic effect was favorable. Conclusion. Monotherapy with losartan in a dosage of 50-100 mg applied during 8 weeks resulted in achieving target values of blood pressure in 65% of patient with mild and moderate hypertension, also including the patients with diabetes mellitus and impaired renal function. Losartan is a safe and metabolically neutral medication.

  2. Stijging van het aantal operaties wegens stressincontinentie

    NARCIS (Netherlands)

    Vierhout, M.E.

    2005-01-01

    Since the introduction of the minimally invasive tension-free vaginal tape (TVT) the number of operations performed for treatment of stress urinary incontinence has increased dramatically from over 1600 in 1999 to more than 4200 in 2003. Both gynaecologists and urologists now perform more TVTs and

  3. Wegener and his Theory of Continental Drift

    Indian Academy of Sciences (India)

    as well as to a few causes in the solar system. Occasionally, we can feel the motion of the ... and in the animal and plant kingdoms may be explained simply if we assume that the continents, ..... interpreted in light of the seafloor spreading hypothesis and the phenomenon of thermo remnant magnetisation (TRM), can help in ...

  4. Sociale media: nieuwe wegen naar sociale innovatie

    NARCIS (Netherlands)

    Salverda, I.E.; Jagt, van der P.D.; Willemse, R.; Onwezen, M.C.; Top, J.L.

    2013-01-01

    Hoewel de rol en impact van internet en de sociale media in de samenleving algemeen worden aangenomen, is het nog niet duidelijk of en hoe het communiceren en delen van informatie via internet en de sociale media bijdragen aan het ontstaan van sociale innovatie. Hoofdvragen van deze verkenning zijn

  5. Heeft het wegen van wetenschappelijke publikaties zin?

    NARCIS (Netherlands)

    Poppen, Rita; Stokman, Frans

    1992-01-01

    In this paper, scientific productivity of academic institutions, research groups, and researchers in Sociology is measured by counting the numbers of scientific publications. We investigate whether the use of weight factors for length, quality, and multiple authorship has arty effect on productivity

  6. Sclerosing Wegener's granulomatosis in the orbit

    DEFF Research Database (Denmark)

    Ostri, Christoffer; Heegaard, Steffen; Prause, Jan Ulrik

    2008-01-01

    and from two enucleated eyes. RESULTS: All three patients had longstanding inflammation in the orbit and involvement of the paranasal sinuses. Proptosis, impaired ocular motility and reduced visual acuity dominated the clinical picture. All histopathological specimens featured granulomatous inflammation...

  7. Adolescente femenino con granulomatosis de Wegener fulminante

    Directory of Open Access Journals (Sweden)

    S C Scheffler-Mendoza

    2017-01-01

    Full Text Available Adolescente femenino de 13 años de edad, originaria de Guerrero, grupo étnico mixteco, padres analfabetos y con poco entendimiento del español. Sin otros antecedentes de importancia para el padecimiento. Inició un mes previo con la aparición de una pápula hipercrómica en párpado superior derecho que en los 10 días previos al ingreso aumentó de volumen generando proptosis. Al interrogatorio se negó dolor, lagrimeo, fiebre, o pérdida de peso. Ingresó con fiebre (39.0°C, palidez generalizada, proptosis derecha con exposición de córnea y conjuntiva, eritema periorbitario, movimientos oculares y agudeza visual disminuidos (i.e. contaba dedos a 1 m, pupila con tendencia a midriasis, hiperreactividad a la luz, y fondo de ojo con papila hiperémica edematosa y tortuosidad peripapilar. El resto de exploración no mostró datos relevantes. Se hospitalizó para iniciar tratamiento antimicrobiano parenteral de amplio espectro (i.e. ceftriaxona y vancomicina y abordar proptosis unilateral.

  8. Kamferintoxicatie na inname van mottenballen 'wegens hoofdpijn'

    NARCIS (Netherlands)

    Peters, Anna-Linda; Dekker, Eline; Michels, Wieneke M.

    2011-01-01

    Camphor is a toxic hydrocarbon, found in numerous over-the-counter medicinal products and chemist-shop items. The consequences of camphor poisoning depend on the dose, and severe poisoning can result in death. Ingestion of camphor can cause seizures, apnoea, renal insufficiency, raised hepatic

  9. Alfred Marshall, o capitalismo e sua utopia social Alfred Marshall, capitalism and his social utopia

    Directory of Open Access Journals (Sweden)

    Laura Valladão de Mattos

    2011-12-01

    Full Text Available Este artigo visa analisar a posição de Marshall em relação ao capitalismo de sua época e às possibilidades de mudança social. Argumenta-se que, apesar de ser um grande defensor do sistema de liberdade econômica, Marshall considerava fundamental sanar o problema da pobreza e da indigência que assolava e degradava física, moral e intelectualmente boa parte da população. Todavia, ao contrário dos socialistas e coletivistas que visavam extinguir as principais instituições vigentes (a concorrência, a propriedade privada, o trabalho assalariado, entre outras, o autor vislumbrava uma sociedade melhor ainda sob a égide dessas instituições capitalistas. Essa situação melhor poderia ser atingida por meio da intervenção do Estado e de mudanças importantes nos valores dos indivíduos - que envolveriam a adoção de uma postura mais nobre e cavalheiresca no seu agir econômico.This paper analyses Marshall's view in relation to capitalism and to the possibilities of social change. It is argued that in spite of being an important defender of the system of economic liberty, Marshall thought it was crucial to solve the problems of poverty and indigence that degraded physically, morally and intellectually a great part of the population. He rejected the socialists and collectivists solutions - that aimed at extinguishing the main prevailing institutions, such as competition in the market and private property, and wage-labor; and defended that a better society could be built preserving the key institutions of capitalism. He believed that this better situation could be achieved by prompt intervention of the State, and by important changes in the values of the individuals of society, that involved more nobility and chivalry in their economic action.

  10. Solar power stations for all roofs - two enterprises combine solar power generations and franchising; Fuer jedes Dach ein Solarkraftwerk - wie zwei Unternehmer Sonnenenergie und Franchising verbinden

    Energy Technology Data Exchange (ETDEWEB)

    Meyeren, T. von

    1997-12-31

    A project is presented in which two partners cooperate in roof-mounted solar power units. Prospects are good: Although the German market for photovolatic systems is still not in full swing, there are good chances worldwide. (orig.) [Deutsch] `Die Zeit is reif, etwas zu tun` fanden Lothar Kuhn, Elektromeister aus Starzach in Wuerttemberg, und Alfred Ritter, Inhaber des Schokoladen-Unternehmens Ritter Sport, angesichts der Zurueckhaltung der grossen deutschen Energieunternehmen gegenueber der Solar-Energie. Sie beschlossen, sich der Energieinteressen der Menschen konstruktiv anzunehmen, der eine - Alfred Ritter - als Kapitalgeber, der andere - Lothar Kuhn - als geschaeftsfuehrender Gesellschafter der im Juni 1996 gegruendeten Sunlive Solarnetwork GmbH and Co KG, auf Schloss Weitenburg in Starzach und zugleich Experte auf dem Gebiet der Solarstrom-Erzeugung. Die Vision:Jedes Dach soll ein solares E-Werk werden. Die Chancen: Nie besser als heute. Der deutsche Photovoltaik-Markt ist unterentwickelt, Prognosen bescheinigen jedoch weltweit gross Entwicklungschancen in wirtschaftlicher und technischer Hinsicht.(orig./AKF)

  11. Multiple Intestinal Perforation Due To Wegener?s Granulotamosis: Case Report

    Directory of Open Access Journals (Sweden)

    Nazif Zeybek

    2010-05-01

    Full Text Available Wegener’s granulomatosis is one of the well known vasculitis, which results with necrotizing granulomatous lesions in the upper and lower respiratuary system and glomerulonephritis. Vasculitis is also observed in several other tissues and organ systems including gastrointestinal system. However, gastrointestinal involvement in Wegener’s granulomatosis is extremely rare. This report presents a patient with Wegener’s granulomatosis, wo was diagnosed to have multiple intestinal perforations.

  12. Wegener`s granulomatosis and mucoromycosis: A case study and review of literature

    Directory of Open Access Journals (Sweden)

    Sayyed Mojtaba Abtahi

    2012-01-01

    Full Text Available Mucormycosis is a fatal invasive infection which mostly involves diabetic or immunosuppressed patients. Early diagnosis, improving immunosuppression, systemic antifungal therapy, and surgical debridement are necessary for successful treatment. In this case study, we represent a known case of Wegener′s granulomatosis (WG, with concomitant sinusal mucormycosis mimicking vasculitic disease relapse, which was successfully treated with surgical debridement, amphotericine, and intravenous immunoglobuline.

  13. Geological features and geophysical signatures of continental margins of India

    Digital Repository Service at National Institute of Oceanography (India)

    Krishna, K.S.

    margins of India, with which some of the main geological features of continental margins have been modified. This article provides a brief review on theory of plate tectonics for understanding the process of intra- continental breakup..., thereby the results are discussed for classification of the margins. The Theory of Plate Tectonics The theory of continental drift, which paves the way for discovery of plate tectonics, was put forward by Alfred Lother Wegener as early as in 1912...

  14. Cognitive continental drift: how attitudes can change the overall pattern of cognitive distances

    OpenAIRE

    Claus-Christian Carbon

    2010-01-01

    By the late Carboniferous period, the continents that today make up North America and Europe collided with the southern parts of Gondwana to form the western half of the last supercontinent Pangea. From this moment on, North America and Europe have steadily been drifting apart, as was initially described by Alfred Wegener in 1915. In this paper a cognitive counterpart of this continental drift is described—which progresses much faster than the phenomenon of plate tectonics. Distance estimatio...

  15. History and Nature of Science enriched Problem-Based Learning on the origins of biodiversity and of continents and oceans

    OpenAIRE

    Sousa, Cristina

    2014-01-01

    [EN] The episode of the History of Science (HOS) on the theory of continental drift proposed by Alfred Wegener has been considered an excellent example for teaching students aspects of Nature of Science (NOS) and the relation of Science with social and tecnological contexts. We implemented a NOS and HOS-enriched Problem-Based Learning environment at the middle (year 7 of the Portuguese National Curriculum) and secondary level (year 10) for teaching the origins of biodiversity and of continent...

  16. The isolation of (6S, 9S-cyclo(prolylvalyl from marine actinomycete, by use of high speed countercurrent chromatography

    Directory of Open Access Journals (Sweden)

    SINISA DJORDJEVIC

    2002-01-01

    Full Text Available The marine actinomycete B 1758 came from the actinomycete collection of the Alfred Wegener Institute for Polar and Marine Research in Bremerhafen, Germany. 1.079 g of raw extract was obtained by fermentation. Seven fractions were separated by column chromatography on silica gel. Fraction 4 was separated by high speed countercurrent chromatography. Fraction 4.6 yielded 5.2 mg of (6S, 9S-cyclo(prolylvalyl.

  17. La dérive des continents, son accueil à Neuchâtel et parmi les géologues alpins

    OpenAIRE

    Schaer, Jean-Paul

    2003-01-01

    International audience; At the beginning of the XX th century, a majority of geologists believe that the Earth is cooling.To adapt to its contraction, its crust must fold itself, forming mountains ranges who take birthin geosynclines, equally produced by the effects of contraction. In 1912, the meteorologist Alfred Wegener proposed that mountains ranges spring out through the confrontation of drifting continents floating on the top of the heavier rocks of the sima, also present under the ocea...

  18. Progress report on the scientific data compilation and analyses in support of the development of a CCAMLR MPA in the Weddell Sea (Antarctica)

    OpenAIRE

    Teschke, Katharina; Bornemann, Horst; Bombosch, Annette; Brey, Thomas; Brtnik, Patricia; Burkhardt, Elke; Dorschel, Boris; Feindt-Herr, Helena; Gerdes, Dieter; Gutt, Julian; Hain, Stefan; Herata, Heike; Jerosch, Kerstin; Knust, Rainer; Kock, Karl-Hermann

    2013-01-01

    At the CCAMLR meeting in 2012, the Commission welcomed the offer of Germany to take the lead in developing a Weddell Sea MPA for consideration in 2014. Subsequently, the German Federal Ministry of Food, Agriculture and Consumer Protection tasked the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research to compile and analyse scientific data for identifying areas which require particular protection in the Weddell Sea. Work under this project started mid-April 2013. This prog...

  19. School Counseling for African American Adolescents: The Alfred Adler Approach

    Science.gov (United States)

    Sapp, Marty

    2010-01-01

    This article discusses how Adlerian counseling can be used as a form of school counseling for African American adolescents. Moreover, school counseling for African American adolescents is discussed within the context of African American culture. Due to the strength-based nature of Adlerian approach, it can capitalize on African American…

  20. Orjastaja kirjutab talle sobivat ajalugu / Alfred Käärmann

    Index Scriptorium Estoniae

    Käärmann, Alfred, 1922-2010

    2002-01-01

    Venemaa versioon "ajaloolisest tõest" seoses Baltikumi lülitamisega NSVLi koosseisu ja sellele järgnevate sündmustega. Tekstilõigud on võetud Igor Põhhalovi artiklist ajalehe Spetznaz Rossii selle aasta numbrist

  1. Not so strangers. Patricia Highsmith according to Alfred Hitchcock

    Directory of Open Access Journals (Sweden)

    Peralta, Jorge Luis

    2010-07-01

    Full Text Available In this work I propose to analyze how the cinematographic transposition of Strangers on a train has changed the suffocating amoral world of Patricia Highsmith in a typical Hitchcockian frantic suspense story, blurring the darkest edges of the characters and situations of the original novel. The aim is not to determine whether the film is «more», «better» or «worse» than the text –an unproductive enterprise– but to reflect on the operations made by the director to seize the literary work and make of it a film that responds to his own vision of the world and of cinema.

  2. Alfred P. Gage and the Introductory Physics Laboratory

    Science.gov (United States)

    Greenslade, Thomas B., Jr.

    2016-01-01

    This article is about a late 19th-century teacher of secondary school physics. I was originally interested in the apparatus that he sold. This led me to the physics books that he wrote, and these took me to his unusual ideas about ways to use laboratory time to introduce students to the phenomena of physics. More than 100 years later educational…

  3. Sir Alfred Bray Kempe – An Amateur Kinematician

    Indian Academy of Sciences (India)

    sriranga

    1954-05-06

    He played first class cricket for a record 44 seasons even at the age of sixty. He played his last test cricket at the age of fifty. He captained England, Gloucestershire county. He is credited as the inventor of most of the batting strokes in display today. Roger Bannister (1929–): On May 6, 1954 he ran the first sub-four-minute ...

  4. 'ANTON, Hans Hubert, HAVERKAMP, Alfred, Trier im Mittelalter'

    OpenAIRE

    Monnet, Pierre

    2013-01-01

    Peu de villes en Allemagne peuvent se prévaloir d’une telle ancienneté et d’une telle urbanité. C’est le cas d’Augusta Treverorum, un peu une »ville-mère«, dont l’Université fondée en 1473, a édité et dirigé, à l’occasion du deuxième millénaire, une histoire de la cité en trois volumes. Les deux premiers sont diponibles depuis maintenant longtemps (Heinz Heinen, Trier und das Trevererland in römischer Zeit, 1985 (2e éd. 1993) et Kurt Düwell, Franz Irsigler (dir.), Trier in der Neuzeit, 1988 (...

  5. Alfred Thayor Mahan and Space: A Necessary Unity.

    Science.gov (United States)

    1986-06-01

    they explain a great deal. It was not until Sir Edmond Halley, brought Sir Issac Newton’s discoveries to light that the mystery of Keppler’s Laws...space programs, future space efforts, orbitology/orbital mechanics, and the writings of H. Jomini, A. T. Mahan, and Sir Julian Corbett. In order to...Foreign Space Programs, Future trends, Kepler, Newton , gravity, mechanical energy, Hohmann transfer, Least energy, LEO, GEO, HEO, <. Cis-Lunar, Lunar

  6. Organização empresarial em Alfred Marshall

    Directory of Open Access Journals (Sweden)

    Jaques Kerstenetzky

    2004-06-01

    Full Text Available Encontra-se na obra de Marshall uma abordagem ao ambiente empresarial que difere de sua tradicionalmente considerada contribuição à economia. Embora Marshall seja o fundador da vertente do equilíbrio parcial da microeconomia, seu trabalho no tema da organização empresarial é muito mais rico do que esta contribuição específica. O artigo explora a análise de cunho histórico e institucional desenvolvida por Marshall no tema da firma, dos mercados e dos ambientes empresariais. Como resultado, sugere que Marshall pode ser apontado como precursor de abordagens contemporâneas ao tema, como a abordagem das capacitações organizacionais, e da grande corporação americana, de autores como Berle e Means e Chandler.We can find in Marshall’s works an approach to business environments that is different from his traditionally accepted contribution to mainstream economics. Though Marshall is indeed the founder of the partial equilibrium analysis branch of traditional microeconomics, his work on the theme of business is much richer than his specific contribution to microeconomics. The article explores Marshall's institutional and historical analysis of firms, markets and of business environments. As an outcome, it suggests that Marshall can be pointed out as a forerunner of modern approaches to the theme, like Berle and Means’s and Chandler’s works on corporations, and the capabilities approach to the theory of the firm.

  7. Sir Alfred Bray Kempe – An Amateur Kinematician

    Indian Academy of Sciences (India)

    sriranga

    rate in quality. He wrote several papers mostly on al- gebra with special laws, which all bear the stamp of his impressive ability. His legal training always led him to make very lucid and precise statements. He was Presi- ... mechanisms like that of Roberts, Evans, Chebyshev, etc. were developed. Incidentally, the now famous ...

  8. Alfred Russel Wallace and the elimination of the unfit

    Indian Academy of Sciences (India)

    2012-03-23

    Mar 23, 2012 ... giving to the pure instincts of women the selective power in marriage. (Wallace 1894, p 87). Without making some numerical estimate of this kind it is impossible to realise the severity, of the struggle continually going on in nature and the resultant elimination of the unfit. (Wallace 1895, p 438). Accepting ...

  9. Väljavõtteid kunstikoguja Alfred Rõude mälestuste käsikirjast / Alfred Rõude

    Index Scriptorium Estoniae

    Rõude, Alfred

    1998-01-01

    Andrus Johanist, tema loomingust. Meenutusi A. Johani 'Pallases' õppimise ajast, Eestis 1933. ja 1936. a. koos tehtud kunstiretkedest, sel ajal A. Johanil valminud töödest. A. Johani kunstipärandist (Tallinn, aug. 1946). A. Rõude kogus süstemaatiliselt A. Johani töid

  10. Case note: Gerechtshof Leeuwarden (Wegener e.a./Hunter Select)

    NARCIS (Netherlands)

    Hugenholtz, P.B.

    2003-01-01

    Overname van personeelsadvertenties uit kranten in online vacaturebank. Is de vacaturerubriek een 'databank' in de zin van de Databankenwet? Het Hof oordeelt in afwijking van de rechter in eerste aanleg van wel. De wettelijke definitie impliceert geen eis van 'snel en efficiënt kunnen raadplegen van

  11. la granulomatose de wegener a propos de trois localisations orl ...

    African Journals Online (AJOL)

    GW) est une vascularite nécrosante de cause inconnue, touchant les voies respiratoires et le rein. Sa prévalence a été estimée à 3 cas pour 100000 per- sonnes (1). Le tableau clinique de la GW est dominé par l'atteinte.

  12. Cancer preceding Wegener's granulomatosis: a case-control study

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Mellemkjaer, Lene; Sorensen, Inge J

    2009-01-01

    OBJECTIVE: To investigate whether patients with WG have an increased risk of malignancies prior to and/or around the time of the vasculitis diagnosis, as suggested by previous studies. METHODS: A total of 293 WG patients were included in the study. Ten gender- and age-matched controls were selected...... randomly for each patient from the Danish Central Population Register. Information on malignancies was obtained through the Danish Cancer Registry. Occurrence of malignancies before WG diagnosis among patients and before WG diagnosis of their matched case among controls (reference date) was compared...

  13. Treatment of orbital inflammation with rituximab in Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Baslund, Bo; Wiencke, Anne Katrine; Rasmussen, Niels

    2012-01-01

    . Immunosuppressive medication (mycophenolate and prednisolone) was administered to 3 patients at the time of rituximab therapy. Three patients had previously been treated with anti-tumour-necrosis-factor-alpha antibodies, and one of these patients had also received cyclophosphamide as treatment for orbital...

  14. Granulomatosis with Polyangiitis (Wegener Granulomatosis Mimicking Infective Endocarditis

    Directory of Open Access Journals (Sweden)

    Imène Rachdi

    2014-10-01

    IE should be ruled out before initiation of immunosuppressive treatment. If the disease progresses despite antimicrobial treatment, vascular diseases should be rapidly taken into account in differential diagnosis and treated early to avoid fatal complications.

  15. A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener

    Directory of Open Access Journals (Sweden)

    James Norman

    2014-01-01

    Full Text Available Neurological manifestations of GPA are common, most frequently as a peripheral neuropathy. Cerebritis as a principal presentation is extremely rare. We report a patient who presented with subacute progression of ataxia, confusion, and vacant episodes. An MRI of her brain showed bilateral signal abnormalities in the cingulate and superior sagittal gyrus while a staging CT revealed a mass in the right upper lobe of the patient’s lung with a satellite nodule. C-ANCA antibodies specific for PR3 at high titres were positive and a diagnosis of GPA was made. The patient was commenced on intravenous methylprednisolone followed by cyclophosphamide and responded well to treatment. GPA is a rare and treatable differential diagnosis for confused patients with acute or subacute neurological features and unusual MRI findings.

  16. Granulomatosis with polyangiitis (Wegener): clinical aspects and treatment.

    Science.gov (United States)

    Comarmond, Cloé; Cacoub, Patrice

    2014-11-01

    Granulomatosis with polyangiitis (GPA) is a systemic necrotizing vasculitis, which affects small- and medium-sized blood vessels and is often associated with cytoplasmic ANCA. GPA occurs in patients between 45 and 60 years old of both genders, and is rarely observed in blacks. The prevalence of GPA increases along a south-north gradient in Europe (20 to 150/million). The main clinical characteristics involve the upper and/or lower respiratory tract and kidneys. Ear, nose and throat manifestations with recurrent sinusitis and crusting rhinorrhea are usually severe. Lung nodules are frequently seen, sometimes excavated. Renal involvement is characterized by rapidly progressive necrotizing glomerulonephritis with extracapillary crescents. Limited forms of GPA predominantly affect the upper respiratory tract, whereas generalized forms of GPA include renal manifestations and/or alveolar hemorrhage and/or vital organ involvement with an altered general condition. The combination of immunosuppressant drugs and corticosteroids has converted this typically fatal illness into one in which 80% of patients achieve remission. However, despite considerable therapeutic progress over the last decades, relapses remain frequent (50% at 5 years), and maintenance treatment is now the main therapeutic challenge. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Scleritis in patients with granulomatosis with polyangiitis (Wegener).

    Science.gov (United States)

    Cocho, Lidia; Gonzalez-Gonzalez, Luis Alonso; Molina-Prat, Nicolas; Doctor, Priyanka; Sainz-de-la-Maza, Maite; Foster, C Stephen

    2016-08-01

    To describe and compare clinical features, complications and outcomes in patients with granulomatosis with polyangiitis (GPA)-associated scleritis with those seen in idiopathic and other autoimmune-associated scleritis, and to further describe the features that may serve as an indicator of life-threatening systemic disease. We retrospectively reviewed electronic health records of all patients with scleritis seen at two tertiary care centres. Of 500 patients, 14 had GPA-associated scleritis and were included in this analysis. Measures included were age, gender, laterality, visual acuity and underlying systemic or ocular diseases. Clinical features (location, pain, inflammation) and ocular complications of these patients (decrease of vision, concomitant anterior uveitis and ocular hypertension) were studied and correlated. Fourteen of 500 patients with scleritis were GPA associated. Most of the patients with GPA-associated scleritis presented with sudden onset, bilateral, diffuse anterior scleral inflammation, with moderate-or-severe pain. Vision loss was not significantly different, and pain was more severe in these patients than in those with idiopathic scleritis. When compared with patients with other underlying autoimmune diseases, there were no significant differences found in epidemiological or clinical signs. Necrotising scleritis and corneal involvement were more commonly observed in GPA than in idiopathic scleritis and other autoimmune diseases and are often the presenting feature of the disease. The presence of necrotising changes or corneal involvement in the setting of scleral inflammation is highly suggestive of an underlying systemic vasculitis, of which GPA is the most common. These features should alert the doctor/optometrist and prompt a thorough diagnostic approach and an aggressive treatment given that it could reveal a life-threatening disease. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  18. [Granulomatosis with polyangiitis (Wegener). Description of 15 cases].

    Science.gov (United States)

    Martínez-Morillo, Melania; Grados, Dolors; Naranjo-Hans, Dolores; Mateo, Lourdes; Holgado, Susana; Olivé, Alejandro

    2012-01-01

    Granulomatosis with polyangiitis (GP) is a necrotizing vasculitis of unknown etiology that involves small and medium caliber vessels. It is associated with anti neutrophil cytoplasm antibodies (ANCA). It most often affects the respiratory tract and the kidneys and its most important pathologic feature is the presence of necrotizing granulomas. To detail the features of 15 patients with GP diagnosed in a university referral center. Retrospective study: between 1984 and 2009, 15 patients with GP were diagnosed in our center. Epidemiological, clinical, laboratory test as well as pathologic studies and treatment were retrospectively analyzed. Biopsy diagnosis of GP was considered as an inclusion criterion. Fifteen patients were diagnosed: 12 men and 3 women. Mean age at diagnosis: 52.2 years (14-78). 12 patients had a history of smoking. A biopsy was diagnostic in all patients. ANCA were positive in 11 cases, 6 had a cytoplasmic c-ANCA pattern. All patients had pulmonary involvement and seven (40%) had renal involvement. All patients received intravenous glucocorticoids and cyclophosphamide as induction therapy. During the disease progression 5 patients died. The clinical features of this series do not differ from those described by other authors. However, a history of smoking is more common than expected. Frequently used drugs were glucocorticoids and cyclophosphamide (oral and pulse therapy). The course was usually unfavorable, with outbreaks or complications due to immunosuppression, except for those with limited forms. Immunosuppressive therapy should be maintained indefinitely in most cases. Copyright © 2010 Elsevier España, S.L. All rights reserved.

  19. T-cell mediated immunity in Wegener's granulomatosis

    NARCIS (Netherlands)

    Abdulahad, Wayel Habib

    2008-01-01

    Although the pathogenetic mechanisms involved in Wegener’s granulomatosis (WG) are not completely understood, considerable evidence support the concepts that activated T-cells play an important role in disease expression. It is, however, not clear which subsets of T-cells are involved in the

  20. Granulomatosis with Polyangiitis (Wegener Granulomatosis) with Unusual Presentation.

    Science.gov (United States)

    Mannan, M A; Pasha, K; Nahar, S; Begum, K

    2017-01-01

    We came across a 32 years old male admitted in our hospital with prolonged low-grade fever, haemoptysis, leg swelling, weight loss, purpuric rashes and malaena. He received anti-TB treatment at another hospital without any improvement. He was pale with bullous and purpuric lesions over legs and feet. He also had features of consolidation over both lung fields. His CRP was 312mg/L, Urine R/M/E showed 40-50 RBC/HPF, Chest X-ray showed features of bilateral consolidation, c-ANCA-10U/L (positive); Tracheal aspirate for AFB was found to be negative. We diagnosed the case as Granulomatosis with Polyangitis (WG) and started treatment with steroid and cyclophosphamide. But the patient could not be saved probably due to delay in starting management.

  1. A presentation of cerebritis secondary to granulomatosis with polyangiitis (wegener).

    Science.gov (United States)

    Norman, James; Pande, Ira; Taylor, Timothy; Gran, Bruno

    2014-01-01

    Neurological manifestations of GPA are common, most frequently as a peripheral neuropathy. Cerebritis as a principal presentation is extremely rare. We report a patient who presented with subacute progression of ataxia, confusion, and vacant episodes. An MRI of her brain showed bilateral signal abnormalities in the cingulate and superior sagittal gyrus while a staging CT revealed a mass in the right upper lobe of the patient's lung with a satellite nodule. C-ANCA antibodies specific for PR3 at high titres were positive and a diagnosis of GPA was made. The patient was commenced on intravenous methylprednisolone followed by cyclophosphamide and responded well to treatment. GPA is a rare and treatable differential diagnosis for confused patients with acute or subacute neurological features and unusual MRI findings.

  2. Weten is wegen . . . . : Ureumgehalte melk bevestigt noodzaak goede voerweging

    NARCIS (Netherlands)

    Teenstra, E.D.

    2000-01-01

    Afgelopen jaar is veel tijd en energie gestoken in het uniformeren van de gegevensstroom. Vrijwel alle deelnemers beschikken nu over weegapparatuur waarmee ze nauwkeurig de voeropname van het vee kunnen registreren. Voor de berekening van de stikstofbenutting van het vee levert dit belangrijke

  3. Continental drift under the Third Reich.

    Science.gov (United States)

    Buffetaut, Eric

    2003-12-01

    Contrary to what happened in many other countries in the 1930s and 1940s, Alfred Wegener's theory of continental drift was not generally rejected in Nazi Germany, although several leading German geologists of the time did not accept it. It was actually presented as the modern view of Earth history in books and magazine articles aimed at the general public. Although outlandish geological theories such as Hörbiger's Welteislehre were favoured by some Nazi dignitaries, they were not widely accepted in scientific circles. On the other hand, continental drift received official support under the Third Reich, at a time when it was ignored or ridiculed by most earth scientists outside Germany.

  4. Aktiver submariner Vulkanismus am Gakkel Ruecken, Arktischer Ozean

    OpenAIRE

    Schlindwein, Vera; Müller, Christina; Jokat, Wilfried

    2006-01-01

    Aktiver submariner Vulkanismus am Gakkel Rücken, Arktischer OzeanVera Schlindwein, Christian Müller und Wilfried JokatStiftung Alfred-Wegener-Institut für Polar- und MeeresforschungAm alten Hafen 26D 27568 BremerhavenModelle für die Magmaproduktion an mittelozeanischen Rücken sagen eine Abnahme der Magmenmenge und somit Krustendicke für abnehmende Öffnungsraten voraus. Geringe Öffnungsraten und eine kühle Lithosphäre an den Riftachsen sorgen für konduktive Kühlung des oberen Mantels, die das ...

  5. Airborne observations of changes of ice sheet and sea ice in the Arctic using CryoVEx campaign data

    DEFF Research Database (Denmark)

    Hvidegaard, Sine Munk; Skourup, Henriette; Forsberg, René

    cap (Svalbard), the EGIG line crossing the Greenland Ice Sheet, as well as the sea ice north of Alert and sea ice around Svalbard in the Fram Strait. Selected tracks were planned to match CryoSat‐2 passes and a few of them were flown in formation flight with the Alfred Wegener Institute (AWI) Polar‐5......DTU Space have collected surface elevation observations of the Arctic sea ice and land ice since 1998 using laser scanning and radar altimetry from a small fixed‐wing Twin‐Otter aircraft. The observations provide unique datasets for studying ongoing changes, and support the analysis of satellite...

  6. Airborne Lidar and Radar Measurments In and Around Greenland CryoVEx 2006

    DEFF Research Database (Denmark)

    Stenseng, Lars; Hvidegaard, Sine Munk; Skourup, Henriette

    Air Greenland. The main purpose was to collect coincident ASIRAS and laser data at validation sites placed on land ice and sea ice in the Arctic area and offer logistic support to ground teams. The data collected will be important for the understanding of CryoSat-2 radar signals. A number...... at DNSC and the Alfred Wegener Institute (AWI). Since then an intensive collaboration between ESA, AWI and DNSC have ensured a solid processing of data where many minor and major problems have been identified and solved. Different investigations of the ASIRAS datation have also been performed...

  7. CryoVex 2008

    DEFF Research Database (Denmark)

    Hvidegaard, Sine Munk; Forsberg, René; Skourup, Henriette

    2009-01-01

    This report describes the airborne part of the field work of the CryoSat Validation Experiment (CryoVEx) 2008 and the processing of the collected datasets. The airborne part of the campaign was carried out by DTU Space (former Danish National Space Center, DNSC) using a Twin Otter chartered from....... The datasets from this campaign will be important for understanding the CryoSat-2 radar signals. The airborne part of CryoVEx 2008 was successfully carried out between April 15 and May 8 and the datasets have been stored and secured at DTU Space and Alfred Wegener Institute (AWI). Afterwards extensive data...

  8. Esa Cryovex 2011 Airborne Campaign For Cryosat-2 Calibration And Validation

    DEFF Research Database (Denmark)

    Skourup, Henriette; Einarsson, Indriði; Sørensen, Louise Sandberg

    After the successful launch of CryoSat-2 in April 2010, the first direct validation campaign of the satellite was carried out in the April-May 2011. DTU Space has been involved in ESA’s CryoSat Validation Experiment (CryoVEx) with airborne activities since 2003. To validate the performance...... of Alert and sea ice around Svalbard in the Fram Strait. Selected tracks were planned to match CryoSat-2 passes and a few of them were flown in formation flight with the Alfred Wegener Institute (AWI) Polar-5 carrying an EM-bird. We present an overview of the 2011 airborne campaign together with first...

  9. The Forster Magnetic Anomaly: reading between the lines to better understand a major suture crossing central Dronning Maud Land

    Science.gov (United States)

    Ruppel, Antonia; Eagles, Graeme; Jacobs, Joachim; Jokat, Wilfried; Läufer, Andreas

    2017-04-01

    Combined aeromagnetic and geological investigations in the area of Dronning Maud Land have led to several hypotheses regarding the assembly of East Antarctica as an integral part of Gondwana. One hypothesis suggests that a prominent NE-SW trending magnetic lineament in central Dronning Maud Land, the Forster Magnetic Anomaly (FMA), represents a major suture between rocks with African affinities and Archean to Mesoproterozoic ages in the West and junvenile Early Neoproterozoic rocks of the recently defined TOAST (Tonian Oceanic Arc Super Terrane) in the East. Consistent with this idea, satellite gravity data have recently revealed that a major change in lithospheric thickness coincides with the FMA. The FMA was first identified during aerogeophysical surveys carried out by the Alfred Wegener Institute between 2001 and 2005, and lies well to the south of isolated mountainous outcrops that do not directly help to identify the anomaly source. The Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research and the Federal Institute for Geosciences and Natural Resources collected aerogeophysical data in 2015-17 from Neumayer III and Kohnen stations, with the objective to densify existing coverage of the FMA from a line spacing of 10 km up to a line spacing of 5 km. We will present preliminary aerogeophysical data that provide a better image of the FMA itself, and with it an interpretation of the transition from an African continental plate margin to Early Neoproterozoic accretionary rocks.

  10. Inherent veilige 80 km/uur-wegen : ontwikkeling van een strategie voor een duurzaam-veilige (her)inrichting van doorgaande 80 km/uur-wegen. Deel I: keuze van de relevante wegen en het opstellen van criteria en eisen.

    NARCIS (Netherlands)

    Minnen, J. van

    1993-01-01

    The former Dienst Verkeerskunde of Rijkswaterstaat commissioned SWOV Institute for Road Safety Research to develop a strategy for an "inherent safe" reconstruction of 80 km/h through roads in the Netherlands. The first part of this study is the conceptualization phase. It classifies 80 km/h through

  11. The Individual Psychology of Alfred Adler: Toward an Adlerian Vocational Theory.

    Science.gov (United States)

    Watkins, C. Edward, Jr.

    1984-01-01

    Presents an Adlerian vocational theory with several hypotheses and corollaries regarding: (a) life style, (b) work as life task, (c) family atmosphere and relationships, and (d) early recollections. Develops predictive vocational statements and offers the resulting framework as a stimulant to generate further study of Adlerian vocational…

  12. Proceedings of the second Alfred O. Nier symposium on inorganic mass spectrometry

    International Nuclear Information System (INIS)

    Green, L.W.

    1996-01-01

    The proceedings are organized under the following headings: thermal ionization mass spectrometry, applications and instrumentation; inductively coupled plasma and glow discharge mass spectrometry; gases; laser resonance ionization; general. Topics of nuclear significance include: determination of trace iron in zirconium; characterization of uranium in surface waters; subpicogram quantities of technetium; measurement of isotope ratios; determination of hydrogen and deuterium in zirconium and its alloys; Kr and Xe isotopic measurements; Kr-85 detection; SIMS study of zirconium corrosion; isotopes at CEA (Commissariat a l'Energie Atomique). All the papers have been abstracted separately for INIS

  13. Parents' perceptions about the health and well-being of farm schools / Leuba Alfred Mphahlele

    OpenAIRE

    Mphahlele, Leuba Alfred

    2008-01-01

    Various research reports and articles in the popular press have highlighted the obstacles and negative conditions that learners experience at some farm schools in South Africa. These obstacles and conditions are not conducive to the health and well-being of farm schools and violate farm school learners' rights to receive a high quality of education. The aim of this research was to establish how parents of farm school learners perceive the health and well-being of farm schools. A liter...

  14. Comparison of statistical evaluation of criticality calculations for reactors VENUS-F and ALFRED

    Directory of Open Access Journals (Sweden)

    Janczyszyn Jerzy

    2017-01-01

    Full Text Available Limitations of correct evaluation of keff in Monte Carlo calculations, claimed in literature, apart from the nuclear data uncertainty, need to be addressed more thoroughly. Respective doubts concern: the proper number of discarded initial cycles, the sufficient number of neutrons in a cycle and the recognition and dealing with the keff bias. Calculations were performed to provide more information on these points with the use of the MCB code, solely for fast cores. We present applied methods and results, such as: calculation results for stability of variance, relation between standard deviation reported by MCNP and this from the dispersion of multiple independent keff values, second order standard deviations obtained from different numbers of grouped results. All obtained results for numbers of discarded initial cycles from 0 to 3000 were analysed leading for interesting conclusions.

  15. Chartres – 44 rue des Bas-Bourgs, rue Alfred Piébourg

    OpenAIRE

    Lévêque, Stéphane

    2014-01-01

    Une étude d'évaluation a été effectuée préalablement à la construction d'un immeuble de 289 m2. Il ressort de la surveillance de 26 creusements de puits de fondations, et après réalisation de relevés stratigraphiques, que le site n'a pas été occupé durant l'Antiquité, ni durant les périodes médiévales et modernes. L'apport de remblais pendant la période antique a eu pour fonction de niveler le site afin, probablement, de le rendre utilisable dans un but agricole.

  16. Proceedings of the Alfred O. Nier symposium on inorganic mass spectrometry

    International Nuclear Information System (INIS)

    Rokop, D.J.

    1993-05-01

    Over 100 inorganic mass spectroscopists, including representatives from 9 different countries, attended. This proceedings contains 12 papers, 11 abstracts, and 38 poster abstracts; an author index is included

  17. Symposium for Alfred Wolf's 75th birthday at American Chemical Society meeting

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-02

    This report contains abstracts from the symposium presented by the Division of Nuclear Chemistry and Technology of the American Chemical Society. Sessions covered the following topics: Therapeutic radionuclides--Making the right choice; Aspects of nuclear science; Nuclear structure with large gamma-ray detector arrays and their auxiliary devices; Thirty years of research in nuclear dynamics--From fission to the quark-gluon plasma; Chelated metal ions for diagnosis and therapy; Radiochemistry--Basic and applied; and Applications of small accelerators in science and industry.

  18. Symposium for Alfred Wolf's 75th birthday at American Chemical Society meeting

    International Nuclear Information System (INIS)

    1998-01-01

    This report contains abstracts from the symposium presented by the Division of Nuclear Chemistry and Technology of the American Chemical Society. Sessions covered the following topics: Therapeutic radionuclides--Making the right choice; Aspects of nuclear science; Nuclear structure with large gamma-ray detector arrays and their auxiliary devices; Thirty years of research in nuclear dynamics--From fission to the quark-gluon plasma; Chelated metal ions for diagnosis and therapy; Radiochemistry--Basic and applied; and Applications of small accelerators in science and industry

  19. Learning How to See and Feel: Alfred Lichtwark and His Concept of Artistic and Aesthetic Education

    Science.gov (United States)

    Priem, Karin; Mayer, Christine

    2017-01-01

    Focusing on Lichtwark's concept of museology, this article shows what role he envisaged for art in public life at a time when the rise of mass consumption and popular culture created new lifestyles. Lichtwark's concept of artistic and aesthetic education did not only extend to museums and classrooms but also to dilettantism as a basis for…

  20. Citation for presentation of the 2010 Alfred Treibs Award to John Volkman

    Science.gov (United States)

    de Leeuw, Jan W.

    2012-07-01

    Over the past decades, Dr. John Volkman has established himself as a world authority on the discovery and application of biomarkers in organic geochemistry, environmental geochemistry, petroleum geochemistry and palaeoclimatology. His work has laid the foundation on which much modern biomarker research is based and his studies of lipids in microalgae, in particular, have had a considerable influence and is widely cited. He has identified many new compounds including sterols, alcohols, diols and hydrocarbons. He has written a large number of review papers which are commonly used by younger organic geochemists to become acquainted with the field and as reference work by many others. John Volkman is truly exceptional in the breadth of expertise, his ability to integrate different sub-disciplines and his openness for young organic geochemists to act as a sparring-partner in scientific discussions. John has achieved this very impressive record even though he has not been employed as a “hard-core” organic geochemist for the last two decades but has nevertheless remained active in organic geochemistry in his “free” time. In addition, John's contributions to more applied fields of research are also numerous.

  1. WHEN GOD TALKS BACK. UNDERSTANDING THE AMERICAN ENGANGELICAL RELATIONSHIP WITH GOD. ALFRED A KNOPF, NEW YORK.

    Directory of Open Access Journals (Sweden)

    Tanya Luhrmann

    2012-12-01

    Full Text Available This book is started with the main question, how come some people in the USA believe in an invisible being, that is God. How has belief in God come to influence people’s lives? How has God come to be really present in human life? Almost 100 percent people in the US, believe in God according to a Gallup Poll (Luhrmann, 2012: xi. In addition, religious enthusiasm for American has grown increasingly rapidly. Throughout the 20th century, American churches and congregations have developed remarkably (Luhrmann, 14. Even Luhrmann gives an example about the paradoxical things. Many people thought that the hippie vision would bring radical revolutionaries movement that threated the right wing. As a contrary, Christian Hippies play significant roles in making religion to be able publicly accepted (even though there were on drugs (Luhrmann 16-17

  2. Muusikamaailm : Pfingstfestspiele (suvistefestival) Baden Badenis. Glyndebourne'is, Leipzigis... . Strasbourg Pariisis. Alfred Brendeli juubeliks / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    H. von Karajani mälestuseks korraldatud suvistepühafestivalist Baden Badenis. Festivalidest : Glyndebourne'i ooperifestivalist, Leipzigi Bachi festivalist, Schwetzingeni lossifestivalist. Strasbourg'i ooperiteatri külalisetendustest Pariisi Chatelet' teatris. A.Brendeli 70. juubeli tähistamisest Londoni South Bank Centre'is

  3. Sex will never be the same: the contributions of Alfred C. Kinsey.

    Science.gov (United States)

    Bullough, Vern L

    2004-06-01

    Kinsey built upon what other European and American researchers had done, but in his male volume he was much more critical of his predecessors than he was in the female volume. Although he mentioned many of the European sex researchers, several were conspicuous by their absence and, at times, he seemed very moralistic (e.g., that Hirschfeld was not an objective researcher because of his campaign for gay rights or the failure of H. Ellis to have face-to-face contact with his participants). He had little positive to say about psychiatrists in general, although he imparted a more positive message in the female volume. If bibliographical citations are any example, Kinsey explored much more widely in the social sciences in the female volume than he did in the male volume, indicating that he himself acquired greater expertise over the years. Certainly, the female volume was a more well rounded treatment. Overall, the effect of his books was to change the way people looked at sex; indeed, sex could never be the same again.

  4. WEGENER: Solid Body Dynamics Investigation of Venus. Results from Summer School Alpbach 2014.

    Science.gov (United States)

    Bialek, A.; Coyle, S.; Czeluschke, A.; Donaldson Hanna, K.; Donohoe, A.; Hu, H.; Koopmans, R.-J.; Lucchetti, A.; Mannel, T.; Nachon, M.; Nilsson, D.; Shelakhaev, N.; Suer, A.; Timoney, R.

    2015-10-01

    The work presented in this paper was performed by the Orange Team during Summer School Alpbach 2014, which mainly concerns about geophysics of terrestrial planets. A mission is designed to investigate the past and current tectonic and volcanic activity on Venus. During the mission, a simultaneous observations from topographic, magnetic and gravitational measurements will be performed and the combination of the information has the potential to provide an improved understanding of the formation and evolution of the planet.

  5. Haalbaarheidsstudie naar een database voor onderzoek op het gebied van wegen en verkeer.

    NARCIS (Netherlands)

    Reurings, M.C.B. & Schermers, G.

    2008-01-01

    SWOV’s new research programme started in 2007. This research programme consists of ten sub-programmes, and Roads and Traffic is one of them. Research database is a project within this sub-programme. In this project, data needs to be acquired for study of the effects of road and traffic

  6. Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations

    Science.gov (United States)

    Kubaisi, Buraa; Abu Samra, Khawla; Foster, C. Stephen

    2016-01-01

    Summary Granulomatosis with polyangiitis (GPA) is a potentially lethal systemic disorder that is characterized by necrotizing vasculitis of small arteries and veins. The respiratory system is most commonly affected in limited forms of the disease, however upper and lower respiratory system, systemic vasculitis, and necrotizing glomerulonephritis are the characteristic components of the disease triad. The peak incidence is observed at 64–75 years of age, with a prevalence of 8–10 per million depending on geographic location. In this review we focus on the ocular manifestations of the disease which occur in nearly in one third of the patients. In addition we describe the neuro-ophthalmic complications which occur in up to half of cases. We also discuss the current systemic treatment options including corticosteroids, cyclophosphamide, azathioprine, and the available biologic response modifiers including rituximab. The disease remains difficult to diagnose due to the generalized symptomatic presentation of patients with GPA. As a result, several sets of diagnostic criteria have been developed which include clinical, serological, and histopathological findings to varying extents. Early diagnosis and multi-specialty collaboration among physicians is necessary to adequately manage the disease and the potential complications that may result from drugs used in the treatment of the disease. Despite recent advances, more research is necessary to prevent the high rates of mortality from the disease itself and from therapeutic side effects. PMID:27195187

  7. Clinical features and outcomes of 37 Argentinean patients with severe granulomatosis with polyangiitis (wegener granulomatosis).

    Science.gov (United States)

    Orden, Alberto Omar; Muñoz, Sebastián Andrés; Basta, María Cristina; Allievi, Alberto

    2013-03-01

    Most epidemiologic studies involving severe granulomatosis with polyangiitis (SGPA) patients have investigated populations from the northern hemisphere, whereas few studies have been conducted in South America. None of the South American studies have differentiated between localized GPA and SGPA. The present study was designed to describe a cohort of Argentinean patients who were diagnosed with SGPA and to compare this cohort with previously well-described cohorts. We performed a retrospective study that included 37 consecutive SGPA patients who were seen at 2 tertiary centers in Buenos Aires. Nineteen patients (51.3%) were male, and 18 patients (49.7%) were female. The mean age at the onset of symptoms was 48.5 ± 12.01 years. Antineutrophil cytoplasmic antibody (ANCA) was detected in 34 patients (91.89%): 32 patients (86.48%) had a cytoplasmic staining pattern, whereas 2 patients (5.40%) had a perinuclear pattern. Three patients were ANCA-negative. Twenty-four patients (64%) achieved remission, and 7 patients (19%) had response as defined by at least 50% reduction in the disease activity score. Nineteen relapses were observed in 12 patients, and 2 of the relapses were fatal. Overall, there were 14 deaths (37.83%). The present series demonstrated that Argentinean patients have similar demographics, clinical manifestations, and outcomes as the cohorts from the northern hemisphere. There was less granulomatous organ involvement (ear/nose/throat, lung granulomas) in the present cohort compared with other series.

  8. Granulomatosis with polyangiitis (Wegener granulomatosis) as a differential diagnosis of sternal osteomyelitis: the challenges in diagnosis.

    Science.gov (United States)

    Kim, Sang-Dong; Kim, Gun-Woo; Kim, Tae-Eun; Nam, Eun-Jung; Han, Seung-Woo

    2013-12-01

    Although granulomatosis with polyangiitis (GPA) can affect a large number of organ systems and produce a broad spectrum of clinical symptoms, skeletal involvement is very rare, with the exception of facial bone involvement associated with destructive nasal and sinus inflammation. We describe here a 54-year-old man with sternal osteomyelitis and destructive arthritis around the sternoclavicular joint. Despite antibiotics and conventional immunosuppressive treatment, his symptoms deteriorated, and a new mass-like lung lesion was developed. A histopathologic analysis of the lung mass revealed chronic granulomatous inflammation with fibrinoid necrosis, and he was diagnosed with GPA. When a patient with a destructive inflammatory lesion has negative culture results and no response to conventional therapy, we propose that an aggressive approach is necessary for a pathologic diagnosis to exclude the possibility of GPA.

  9. Subglottic stenosis in granulomatosis with polyangiitis (Wegener's granulomatosis): Report of 4 cases.

    Science.gov (United States)

    Horta-Baas, Gabriel; Hernández-Cabrera, María Fernanda; Catana, Rocío; Pérez-Cristóbal, Mario; Barile-Fabris, Leonor Adriana

    2016-01-01

    Subglottic stenosis (SGS) in granulomatosis with polyangiitis (GPA) may result from active disease or from chronic recurrent inflammation. The objective of the study was to describe the clinical features and treatment of patients with subglottic stenosis. We retrospectively reviewed the medical records of all patients with SGS due to GPA diagnosed at Rheumatology deparment between January 2000 and June 2015. We present 4 cases of SGS at our department during a period of 15 years. The interval between the presentation of the GPA and SGS varied between 2 and 144 months. The leading symptoms of SGS were dyspnoea on exertion and stridor. Three patients presented SGS without evidence of systemic activity. Two patients presented SGS grade i and received tracheal dilatation; two recurred and three needed a tracheostomy due to severe airway-limiting stenosis. SGS presents high morbidity. Even though subglottic dilatation provides symptomatic relief, recurrences may present. Severe airway-limiting stenosis often requires tracheostomy. Copyright © 2015 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

  10. Granulomatous polyangitis (Wegener granulomatosis): Clinical findings and results of long-term follow-up.

    Science.gov (United States)

    Şen, Nazan; Aydın Tufan, Müge; Yıldız, Reyhan; Ersözlü Bozkırlı, Emine Duygu; Yücel, Eftal

    2016-09-01

    To evaluate long-term outcome of patients with granulomatous polyangitis (GPA) followed up in a tertiary university hospital. We reviewed medical records of 22 patients with GPA diagnosis confirmed by tissue biopsies between 2004 and 2014. The mean time from the onset of symptoms to diagnosis was 7.8 ± 12.3 months [interquartile range (IR)= 4.0]. The most commonly involved organs were the upper respiratory tract (URT) (72.7%), lower respiratory tract (81.8%) and kidneys (72.7%). URT involvement indicated good prognosis (p= 0.046). Survival in the patients with and without URT involvement was 124.6 ± 6.9 months and 59.7 ± 22.9 months, respectively. End-stage renal failure (ESRF) requiring dilaysis and cardiac involvement were associated with mortality (p= 0.022 and p= 0.026, respectively). Of the 12 dialysis-dependent patients at diagnosis, 11 survived > 3 months and seven regained renal function permanently. Dialysis dependency was significantly lower in patients who received plasmapheresis (p= 0.047). Overall mortality rate was 18% (4/22). Mean survival was 55.9 ± 42.8 months (IR= 84.0). Diagnosis of GPA may be delayed by the nonspecific nature of its symptoms. URT involvement was associated with good prognosis, whereas cardiac involvement and ESRF requiring dialysis were associated with poor outcome. Plasmapheresis may increase the rate of renal recovery in the patients with ESRF requiring dialysis.

  11. Total Nasal Skeletal Reconstruction Disfigured by Granulomatosis with Polyangitis (Wegener Granulomatosis

    Directory of Open Access Journals (Sweden)

    Farhad Hafezi, MD

    2015-02-01

    Conclusions: In spite of contamination to the nasal lining and immune-compromising medications, nasal reconstruction is usually successful when considering these factors. Access to strong and abundant fifth or sixth rib cartilage presents an opportunity to reconstruct nasal destruction due to iatrogenic or autoimmune processes.

  12. Gingival granulomatosis with polyangiitis (Wegener's granulomatosis) as a primary manifestation of the disease.

    Science.gov (United States)

    Fonseca, F P; Benites, B M; Ferrari, Alv; Sachetto, Z; de Campos, G V; de Almeida, O P; Fregnani, E R

    2017-03-01

    Granulomatosis with polyangiitis (GPA) is a potentially lethal disease characterized by systemic necrotizing vasculitis, which affects small- and medium-sized blood vessels and is often associated with serum cytoplasmic antineutrophil cytoplasmic antibody. The upper and lower respiratory tract and kidney are the most involved sites, but oral lesions can be identified in 6-13% of the cases, whereas in only 2% of the cases, oral manifestations represent the first signal of the disease usually as gingival swellings or unspecific ulcerations. Without treatment, the mainstay of which is the combination of immunosuppressants and systemic corticosteroids, GPA may run a fatal course. In this report we describe an original case of GPA affecting a 75-year-old female patient referred to our service due to a gingival swelling with 3-month duration. Although the patient was correctly diagnosed and promptly treated, she died 3 months after the initial diagnosis. © 2016 Australian Dental Association.

  13. The presentation and management of granulomatosis with polyangiitis (Wegener's Granulomatosis) in the pediatric airway.

    Science.gov (United States)

    Lee, Pui Y; Adil, Eelam A; Irace, Alexandria L; Neff, Laura; Son, Mary Beth F; Lee, Edward Y; Perez-Atayde, Antonio; Rahbar, Reza

    2017-01-01

    Granulomatosis with polyangiitis (GPA) is a necrotizing inflammatory disease that can affect the airway. The purpose of this study was to present a case of pediatric laryngotracheal GPA and provide management recommendations based on a thorough review of the literature. Retrospective chart and literature review REVIEW METHODS: A pediatric patient with laryngotracheal and pulmonary manifestations of GPA who underwent chemotherapy and intralesional corticosteroid injection is described. An extensive literature review of pediatric GPA affecting the larynx/trachea was also performed. A pediatric patient presented with acute respiratory distress. Flexible laryngoscopy revealed a laryngeal mass. Magnetic resonance imaging showed circumferential subglottic stenosis, and chest computed tomography demonstrated multiple pulmonary nodules. Laryngeal and tracheal biopsy revealed granulation tissue and primary vasculitis. Labs demonstrated positive cytoplasmic antineutrophil cytoplasmic antibody, consistent with GPA. Methylprednisone, rituximab, cyclophosphamide, and intralesional steroid injection resulted in remission after 12 weeks. Review of the literature revealed two pediatric cases series and 10 case reports of GPA affecting the larynx or trachea. There is a higher prevalence of GPA of the airway in children when compared to adults. Biopsy of the airway lesion may not be necessary and has lower diagnostic yield compared to other GPA subsites. Medical management includes induction therapy followed by maintenance therapy once the disease is in remission. Most patients will require a surgical intervention to maintain the airway. NA Laryngoscope, 127:233-240, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  14. Extracorporeal membrane oxygenation rescue in adolescent with bronchiolitis obliterans-organizing pneumonia like Wegener's granulomatosis.

    Science.gov (United States)

    Falk, Lars; Broman, Lars Mikael

    2017-01-01

    We report a 17-year-old woman with bronchiolitis obliterans-organizing pneumonia (BOOP)-like granulomatosis with polyangiitis developing severe airway obliterations. Pending age, phase and grade of autoimmune treatment, and offering ECMO treatment may be crucial for survival but occasionally preface futility. ECMO-treated patient with BOOP-like GPA has never been described before.

  15. Landwirtschaft und Agrarpolitik in Deutschland und Frankreich auf der Suche nach neuen Wegen

    OpenAIRE

    Schlagheck, Hermann

    2001-01-01

    The concept of integrated rural development also represents a suitable approach for solving rural development problems in Europe. There are several reasons supporting the concept of rural development: changing framework conditions require new solutions and policies; rural areas need region-specific-development concepts; complex decision making requires cooperation between different actors and levels; sector-specific support remains part of region-specific development concepts; integrated rura...

  16. Cranial nerve palsy in Wegener's granulomatosis--lessons from clinical cases

    DEFF Research Database (Denmark)

    Nowack, Rainer; Wachtler, Paul; Kunz, Jürgen

    2009-01-01

    with CT and MRI and the laboratory provided no clues suggesting active vasculitis. However, in both patients the neuropathies fully recovered in response to standard induction protocols of vasculitis. In the absence of organ-specific proof of vasculitis, these treatment decisions were guided...

  17. Het meten en wegen van runderen voor de selectie op vleesproduktie

    NARCIS (Netherlands)

    Vos, M.P.M.

    1969-01-01

    Literature review and introduction A farmer's net profit from beef production depends on the amount he produces, the price he receives for it and the costs of producing it (Fig. 4). The amount of beef is related to a readily measurable characteristic, liveweight per unit age. This is in turn a

  18. Blijvend vlakke wegen - CROW-werkgroep integraal wegontwerp - evaluatie van schadecases uit de praktijk

    NARCIS (Netherlands)

    Egmond-Weijburg, C.; Galjaard, P.J.; Van Gurp, C.A.P.M.

    2008-01-01

    This report presents an inquiry into cases of pavement design, construction and maintenance in which distress has been observed instigated by deeper subgrade or by inadequate attention for the interaction between subgrade and pavement structure. Almost all cases are situated in areas with subgrade

  19. Die DDC auf neuen Wegen - verbale Sucheinstiege für klassifikatorisch erschlossene Titel

    Directory of Open Access Journals (Sweden)

    Christiane Maibach

    2014-12-01

    Full Text Available Die Dewey-Dezimalklassifikation (DDC ist ein mächtiges Instrument der klassifikatorischen Inhaltserschließung. Immer mehr Bibliotheken im In- und Ausland erkennen den Nutzen der international am weitesten verbreiteten Universalklassifikation. Die Deutsche Nationalbibliothek (DNB setzt die DDC seit 2006 für die inhaltliche Erschließung der Bibliografiereihen A, B und H ein. Seitdem wurden rund 800.000 Publikationen mit DDC-Notationen versehen. Der Nutzen von Klassifikationen ist unter Bibliothekar/innen unumstritten. Die Bibliotheksnutzer/innen hingegen wissen oft nicht, dass der Katalog ihrer Bibliothek auch eine systematische Recherche ermöglicht. Ihre Recherchestrategie ist meist verbal. Durch Internetsuchmaschinen wird diese Strategie noch bestärkt. Daher liegt es nahe, auch für die klassifikatorisch erschlossenen Titel einen verbalen Sucheinstieg zu schaffen. Die DDC enthält nicht nur die in vielen Klassifikationssystemen üblichen Registereinträge und Klassenbenennungen, sondern auch die im Rahmen des Projekts CrissCross in großem Umfang erstellten Verknüpfungen zu Schlagwörtern der Gemeinsamen Normdatei (GND, die für diesen Zweck ausgewertet werden können. The Dewey Decimal Classification (DDC is a powerful indexing tool. A rising number of libraries worldwide recognize the benefit of this universal classification. Since 2006 the German National Library (DNB has used the DDC to index titles belonging to series A, B and H of the German National Bibliography. In 2012 100,000 publications were indexed with DDC notations. The benefits of classifications for indexing is widely accepted among librarians. However, library users take a different point of view. Mostly, they are not even aware that their library's catalogue offers a systematic search. Most library users prefer verbal search strategies. This is enforced by internet search engines, which have changed the search habits of library users. Therefore, the obvious solution is to create a verbal access to classified titles. The DDC does not only contain a relative index with verbal elements and class names, but also links to subject headings taken from the German Integrated Authority File (GND. These were established as a part of the CrissCross project. All of these verbal elements can be used to make the DDC accessible by words.

  20. Instability Rules: The Ten Most Amazing Ideas of Modern Science

    Science.gov (United States)

    Flowers, Charles

    2002-03-01

    World-altering discoveries that reveal a universe of uncertainty and constant change Whether probing the farthest reaches of the vast universe or exploring the microscopic world of genetics and the subatomic world of quantum mechanics, Instability Rules is a remarkably informative and engaging look at ten milestone discoveries and their discoverers-a wide range of very human personalities whose insights have dramatically altered our most basic assumptions about human existence during the last century. The stories include Edwin Hubble and the expanding universe, Alfred Wegener and continental drift, Neils Bohr and quantum mechanics, Alan Turing and artificial intelligence, and James Watson and Francis Crick and DNA. Also covering discoveries of the twenty-first century that are already refining these and other ideas, Instability Rules is an exhilarating, sometimes amusing encounter with the defining scientific discoveries of our age.

  1. Selective preservation of organic matter in marine environments - processes and impact on the fossil record

    Science.gov (United States)

    Zonneveld, K. A. F.; Versteegh, G. J. M.; Kasten, S.; Eglinton, T. I.; Emeis, K.-C.; Huguet, C.; Koch, B. P.; de Lange, G. J.; de Leeuw, J. W.; Middelburg, J. J.; Mollenhauer, G.; Prahl, F. G.; Rethemeyer, J.; Wakeham, S. G.

    2009-07-01

    The present paper is the result of a workshop sponsored by the Research Centre Ocean Margins, the International Graduate College EUROPROX and the Alfred Wegener Institute for Polar Research. The workshop brought together specialists on organic matter degradation and on proxy-based environmental reconstruction. The paper deals with the main theme of the workshop, understanding the impact of selective degradation/preservation of organic matter (OM) in marine sediments on the interpretation of the fossil record. Special attention is paid to (A) the influence of the molecular composition of OM in relation to the biological and physical depositional environment, including new methods for determining complex organic biomolecules, (B) the impact of selective OM preservation on the interpretation of proxies for marine palaeoceanographic and palaeoclimatic reconstruction, and (C) past marine productivity and selective preservation in sediments.

  2. ESSReS-PEP, an international and interdisciplinary postgraduate education concept on Earth and Environmental Sciences

    Science.gov (United States)

    Grosfeld, Klaus; Lohmann, Gerrit; Ladstätter-Weißenmayer, Annette; Burrows, John

    2013-04-01

    Promoting young researchers is a major priority of the German Helmholtz Association. Since more than five years graduate and postgraduate education in the field of Earth System and Environmental Science has been established in Bremen and Bremerhaven, north-western Germany. Using the network and collaboration of experts and specialists on observational and paleoclimate data as well as on statistical data analysis and climate modelling from two Universities and the Helmholtz research institute on Polar and Marine Research, master and PhD students are trained to understand, decipher and cope with the challenges of recent climate change on an highly interdisciplinary and inter-institutional level. The existing research infrastructure at the Alfred Wegener Institute in Bremerhaven (AWI), University of Bremen, and Jacobs University Bremen offers a unique research environment to study past, present and future changes of the climate system, with special focus on high latitudinal processes. It covers all kind of disciplines, climate science, geosciences and biosciences, and provides a consistent framework for education and qualification of a new generation of expertly trained, internationally competitive master and PhD students. On postgraduate level, the Postgraduate Programme Environmental Physics (PEP) at the University of Bremen (www.pep.uni-bremen.de) educates the participants on the complex relationship between atmosphere, hydrosphere (ocean), cryosphere (ice region) and solid earth (land). Here, the learning of experimental methods in environmental physics at the most advanced level, numerical data analysis using supercomputers, and data interpretation via sophisticated methods prepare students for a scientific career. Within cooperation with the Ocean University of China (OUC) students are participating one year in the PEP programme during their master studies since 2006, to get finally a double degree of both universities. At the Alfred Wegener Institute for Polar

  3. TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation

    OpenAIRE

    2008-01-01

    TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation correspondence: Corresponding author. Tel.: +49 241 8080208; fax: +49 241 8082613. (Rink, Lothar) (Rink, Lothar) Institute of Immunology, University Hospital, RWTH Aachen University - Aachen--> - GERMANY (Uciechowski, Peter) Institute of Immunology, University Hospital, RWTH Aachen University - Aachen--> - GERMAN...

  4. Symbiogenesis, natural selection, and the dynamic Earth.

    Science.gov (United States)

    Kutschera, U

    2009-08-01

    One century ago, Constantin S. Mereschkowsky introduced the symbiogenesis theory for the origin of chloroplasts from ancient cyanobacteria which was later supplemented by Ivan E. Wallin's proposal that mitochondria evolved from once free-living bacteria. Today, this Mereschkowsky-Wallin principle of symbiogenesis, which is also known as the serial primary endosymbiosis theory, explains the evolutionary origin of eukaryotic cells and hence the emergence of all eukaryotes (protists, fungi, animals and plants). In 1858, the concept of natural selection was described independently by Charles Darwin and Alfred R. Wallace. In the same year, Antonio Snider-Pellegrini proposed the idea of shifting continents, which was later expanded by Alfred Wegener, who published his theory of continental drift eight decades ago. Today, directional selection is accepted as the major cause of adaptive evolution within natural populations of micro- and macro-organisms and the theory of the dynamic Earth (plate tectonics) is well supported. In this article, I combine the processes and principles of symbiogenesis, natural selection and the dynamic Earth and propose an integrative 'synade-model' of macroevolution which takes into account organisms from all five Kingdoms of life.

  5. 'Industry, perseverance, self-reliance, and integrity'. Alfred A. Walton and mid-Victorian working-class radicalism

    OpenAIRE

    Mares, Detlev

    2018-01-01

    Biography of one of the lesser-known Victorian working-class radicals, who was active in political (Chartism, electoral reform), social (O'Brienism, co-operation, trade unionism) and international (International Working Men's Association) movements in the mid-Victorian era. He also was a prolific author of pamphlets and newspaper contributions on political and social questions, esp. land reform, co-operation and working-class representation.

  6. Alfred Schütz’s writings from the perspective of a theory of action’s creativity

    Directory of Open Access Journals (Sweden)

    Javier L. Cristiano

    2013-06-01

    Full Text Available The article proposes a review of the work of Schütz from the question about “creativity” of social action, which was not made expressly by the author but it is in his writings an important principle of response. After positioning the subject in some coordinates of the current sociological discussion, we present four specific fields from schütz’ contributions: the ability to expand and make a creative use of “the social heritage of knowledge”, the individual and collective capacity to imagine action projects, the ability to create and use symbols, and producing with them exclusive worlds of imaginary existence, as well as the ability to give birth to new experiences. It is stated that these four fields outline the contours of a phenomenology of creativity of action, which sets out some open fields for further research.

  7. O fotográfico como retrato e “Readymade” a propósito de Alfred Hitchcock

    OpenAIRE

    Leitão, José António

    2008-01-01

    Revista do IHA, N.5 (2008), pp.208-217 Sempre que se fotografa alguém faz-se retrato. Retrato, precisamente segundo os critérios tradicionais da análise formal: representa-se alguém concreto com fidelidade ao visível. Se a fotografia faz, sempre, mesmo que secundariamente, retrato, isso acontece pela “natureza” do fotográfico: a fotografia é “retrato” do mundo - seu duplo mimético exacto. Não é a Verónica que faz do ícone retrato e, portanto, “verdadeiro” (verum Eikôn)? ...

  8. Genetics Home Reference: granulomatosis with polyangiitis

    Science.gov (United States)

    ... kidneys. This disorder is also commonly known as Wegener granulomatosis. A characteristic feature of GPA is inflammation ... 3 links) Johns Hopkins Vasculitis Center: How is Wegener's Granulomatosis Diagnosed? MedlinePlus Encyclopedia: Wegener's Granulomatosis Merck Manual ...

  9. Rijsnelheden op 80- en 100 km/uur-wegen (II) : verslag van landelijk representatieve snelheidsmetingen voor het project `Monitoring rijsnelheden' op 80- en 100 km/uur-wegen, Fase 3, 2e meting.

    NARCIS (Netherlands)

    Catshoek, J.W.D. & Varkevisser, G.A.

    1995-01-01

    The Transport Research Center (AVV) of the Directorate General for Public Works and Water Management commissioned the SWOV Institute for Road Safety Research to carry out speed measurements on 80 and 100 km/h roads in twelve Dutch provinces. These measurements were executed in the year 1994. The

  10. Hémothorax spontané révélant une vascularite de Wegener chez ...

    African Journals Online (AJOL)

    L'hémothorax spontané demeure une pathologie rare. Ses étiologies sont multiples mais restent parfois inconnues. Chez certains patients, la thoracotomie peut être le seul recours pour déterminer son origine. Les vascularites n'ont pas été rapporté comme cause habituelle des hémothorax spontanés. La grossesse ne ...

  11. Generations of spreading basins and stages of breakdown of Wegener's Pangea in the geodynamic evolution of the Arctic Ocean

    Science.gov (United States)

    Shipilov, E. V.

    2008-03-01

    Chronological succession in the formation of spreading basins is considered in the context of reconstruction of breakdown of Wegener’s Pangea and the development of the geodynamic system of the Arctic Ocean. This study made it possible to indentify three temporally and spatially isolated generations of spreading basins: Late Jurassic-Early Cretaceous, Late Cretaceous-Early Cenozoic, and Cenozoic. The first generation is determined by the formation, evolution, and extinction of the spreading center in the Canada Basin as a tectonic element of the Amerasia Basin. The second generation is connected to the development of the Labrador-Baffin-Makarov spreading branch that ceased to function in the Eocene. The third generation pertains to the formation of the spreading system of interrelated ultraslow Mohna, Knipovich, and Gakkel mid-ocean ridges that has functioned until now in the Norwegian-Greenland and Eurasia basins. The interpretation of the available geological and geophysical data shows that after the formation of the Canada Basin, the Arctic region escaped the geodynamic influence of the Paleopacific, characterized by spreading, subduction, formation of backarc basins, collision-related processes, etc. The origination of the Makarov Basin marks the onset of the oceanic regime characteristic of the North Atlantic (intercontinental rifting, slow and ultraslow spreading, separation of continental blocks (microcontinents), extinction of spreading centers of primary basins, spreading jumps, formation of young spreading ridges and centers, etc., are typical) along with retention of northward propagation of spreading systems both from the Pacific and Atlantic sides. The aforesaid indicates that the Arctic Ocean is in fact a hybrid basin or, in other words, a composite heterogeneous ocean in respect to its architectonics. The Arctic Ocean was formed as a result of spatial juxtaposition of two geodynamic systems different in age and geodynamic style: the Paleopacific system of the Canada Basin that finished its evolution in the Late Cretaceous and the North Atlantic system of the Makarov and Eurasia basins that came to take the place of the Paleopacific system. In contrast to traditional views, it has been suggested that asymmetry of the northern Norwegian-Greenland Basin is explained by two-stage development of this Atlantic segment with formation of primary and secondary spreading centers. The secondary spreading center of the Knipovich Ridge started to evolve approximately at the Oligocene-Miocene transition. This process resulted in the breaking off of the Hovgard continental block from the Barents Sea margin. Thus, the breakdown of Wegener’s Pangea and its Laurasian fragments with the formation of young spreading basins was a staged process that developed nearly from opposite sides. Before the Late Cretaceous (the first stage), the Pangea broke down from the side of Paleopacific to form the Canada Basin, an element of the Amerasia Basin (first phase of ocean formation). Since the Late Cretaceous, destructive pulses came from the side of the North Atlantic and resulted in the separation of Greenland from North America and the development of the Labrador-Baffin-Makarov spreading system (second phase of ocean formation). The Cenozoic was marked by the development of the second spreading branch and the formation of the Norwegian-Greenland and Eurasia oceanic basins (third phase of ocean formation). Spreading centers of this branch are functioning currently but at an extremely low rate.

  12. DDR-Justiz und NS-Verbrechen Band 8 : Sammlung ostdeutscher Strafurteile wegen nationalsozialistischer Tötungsverbrechen

    NARCIS (Netherlands)

    Rüter, Christiaan F.

    2006-01-01

    Volume 8 contains the trial cases finalized between mid-May and the end of August 1949. Most of the cases in this volume involve denunciations, NS-crimes in detainment centers and final phase crimes. Also, there are some dealing with judicial crimes, mass extermination and war crimes, as well as

  13. DDR-Justiz und NS-Verbrechen Band 5 : Sammlung ostdeutscher Strafurteile wegen nationalsozialistischer Tötungsverbrechen

    NARCIS (Netherlands)

    Rüter, Christiaan F.

    2004-01-01

    This volume contains part of the trial cases finalized in the year 1951; the others are published in vol. IV. Again, a number of different criminal complexes are dealt with: - mass extermination crimes, - judicial crimes, - war crimes, - crimes committed in concentration camps and other detainment

  14. Klinisch denken en beslissen in de praktijk. Een man met eenzijdige aanvalsgewijze spierverstijvingen na een halsoperatie wegens maligniteit

    NARCIS (Netherlands)

    Bromberg, J. E.; Niermeijer, J. M.; Hart, W.

    2003-01-01

    A 54-year-old man with a history of generalised tonic clonic seizures presented with complaints of daily unilateral stiffening of the limbs, preceded by paraesthesia. Two years before he had been treated with surgery and radiotherapy for a laryngo-pharyngeal carcinoma. Therefore, epilepsy due to

  15. De relatie tussen ongevallen en etmaalintensiteit op provinciale wegen in Gelderland : intensiteitsmetingen en wegkenmerken van enkelbaans- en dubbelbaanswegen.

    NARCIS (Netherlands)

    Reurings, M.C.B. & Janssen, S.T.M.C.

    2007-01-01

    The aim of the Infrastructure and road safety project is to establish mathematical relations between infrastructural road characteristics and the safety of these roads. In scientific literature such mathematical relations are generally refered to as accident prediction models (APMs). In this report

  16. Evaluatie snelheidscampagne op 80- en 100 km/uur-wegen in Overijssel : rapportage over fase 0, 1 en 2.

    NARCIS (Netherlands)

    Oei, H.-l. & Goldenbeld, C.

    1995-01-01

    In 1994, a speed enforcement campaign was conducted on a two-lane provincial road network in the Dutch province of Overijssel. The campaign was conducted during two phases of around three months each, before and after the summer holidays. Before the start and during the campaign information about

  17. Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

    Science.gov (United States)

    Korkmaz, Brice; Lesner, Adam; Letast, Stephanie; Mahdi, Yassir K; Jourdan, Marie-Lise; Dallet-Choisy, Sandrine; Marchand-Adam, Sylvain; Kellenberger, Christine; Viaud-Massuard, Marie-Claude; Jenne, Dieter E; Gauthier, Francis

    2013-07-01

    Neutrophils are among the first cells implicated in acute inflammation. Leaving the blood circulation, they quickly migrate through the interstitial space of tissues and liberate oxidants and other antimicrobial proteins together with serine proteinases. Neutrophil elastase, cathepsin G, proteinase 3 (PR3), and neutrophil serine protease 4 are four hematopoietic serine proteases activated by dipeptidyl peptidase I during neutrophil maturation and are mainly stored in cytoplasmic azurophilic granules. They regulate inflammatory and immune responses after their release from activated neutrophils at inflammatory sites. Membrane-bound PR3 (mbPR3) at the neutrophil surface is the prime antigenic target of antineutrophil cytoplasmic autoantibodies (ANCA) in granulomatosis with polyangiitis (GPA), a vasculitis of small blood vessels and granulomatous inflammation of the upper and/or lower respiratory tracts. The interaction of ANCA with mbPR3 results in excessive activation of neutrophils to produce reactive oxygen species and liberation of granular proteinases to the pericellular environment. In this review, we focus on PR3 and dipeptidyl peptidase I as attractive pharmacological targets whose inhibition is expected to attenuate autoimmune activation of neutrophils in GPA.

  18. Intra- and inter-rater reliability of endonasal activity estimation in granulomatosis with polyangiitis (Wegener´s).

    Science.gov (United States)

    Garske, Ulrike; Haack, Andrea; Beltrán, Olga; Flores-Suárez, Louis F; Bremer, Jan P; Lamprecht, Peter; Hedderich, Jürgen; Quetz, Joachim; Gross, Wolfgang L; Ambrosch, Petra; Laudien, Martin

    2012-01-01

    Granulomatosis with polyangiitis (GPA) frequently starts with an affection of the nasal and paranasal mucosa. Localised GPA of the nasal mucosa or persistent disease activity ('grumbling disease') is often encountered even under immunosuppressive therapy. Necessity for reconstructive surgery is common and careful scheduling to prevent failure and minimise revision rates is crucial. Therefore, reliable estimation of GPA activity in the upper airways using a score is mandatory for diagnosis, follow-up and scheduling reconstructive surgery. Fifty endoscopic, endonasal images of 45 patients with GPA were used. Twelve (4 German, 8 Mexican) experienced (n=7) and inexperienced (n=5) physicians assessed GPA-activity at two times (T1/T2) in dichotomy and in a grading approach (none, mild, moderate and high activity) using the novel ENT Activity Score (ENTAS). All documents were written in English. Estimation of activity in dichotomy (none vs. mild/moderate/high): Cohen's Kappa (κ) for intra-rater reliability T1/T2 in inexperienced and experienced physicians was κ=0.58 (agreement 85%) and κ=0.72 (agreement 91%). The inter-rater reliability (Fleiss's κ) T1/T2 for inexperienced and experienced physicians was κ=0.62/κ=0.59 and κ=0.50/κ=0.58 respectively. Estimation of activity in grading approach (none, mild, moderate, high): for inexperienced physicians the intra-rater reliability T1/T2 was κ=0.67 (agreement 56%) and the inter-rater reliability at T1/T2 was κ=0.29 (intraclass correlation coefficient, ICC=0.69) and κ=0.27 (ICC=0.59). For experienced physicians the intra-rater reliability T1/T2 was κ=0.80 (agreement 67%) and the inter-rater reliability at T1 and T2 was κ=0.41 (ICC=0.77) and κ=0.39 (ICC=0.75) respectively. Intra-rater reliability is high in decision in dichotomy and even in grading activity. There is no difference for experienced or inexperienced physicians. Inter-rater reliability is high in dichotomy, but low for activity grading. Thus, the ENTAS provides a reliable instrument for assessing, documenting and following GPA-related disease activity in the upper respiratory tract. The relationship of activity and following damage needs to be investigated in further studies.

  19. A case of squamous cell carcinoma of the nasal cavity in a patient with granulomatosis with polyangiitis (Wegener granulomatosis).

    Science.gov (United States)

    Kuan, Edward C; Peng, Kevin A; Gonzalez, Lyndon O; Sercarz, Joel A

    2018-01-01

    We report a rare case of squamous cell carcinoma (SCC) of the nasal cavity arising in a patient with granulomatosis with polyangiitis (GPA). The patient was a 35-year-old man who had been diagnosed 15 years earlier with GPA and treated medically for sinonasal, pulmonary, and renal involvement. He presented to us with left-sided orbital and cheek pain and nasal obstruction. Endoscopy detected a friable, exophytic mass that involved the left lateral nasal wall and septum. Biopsy analysis identified the mass as an SCC. A definitive endoscopic resection was performed, followed by chemoradiation, but the patient exhibited progression of disease 2 months after the cessation of therapy. He then underwent an open craniofacial resection and a second round of chemoradiation. At 7 months of follow-up, he remained disease-free. Sinonasal symptoms in GPA are consistent with those in chronic rhinosinusitis, but the presence of unilateral symptoms may suggest a neoplastic process. Immunosuppressants are implicated in the pathophysiology of this malignancy, but equally plausible is the oncogenic role of chronic inflammation.

  20. De lichttechnische eigenschappen van lichtgekleurde wegoppervlakken : artikel Wegen 56 10: 803-824 t/m 803-325.

    NARCIS (Netherlands)

    Schreuder, D.A.

    1982-01-01

    Cement concrete road surfaces have, because of their light colour, a double luminance yield as compared with bituminous roads. Savings in electricity amount to at least 20% in illumination costs or 5-10% of total maintenance costs. Light colour improves visibility at night. Road markings in white