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Sample records for alexander disease serial

  1. Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matter

    OpenAIRE

    Voorn, van, G.A.K.; Pouwels, P. J. W.; Salomons, G.S.; Barkhof, F.; Knaap, van der, W.

    2009-01-01

    Introduction Alexander disease is a rare disorder of the central nervous system with characteristic symmetric white matter abnormalities with frontal predominance on magnetic resonance (MR) images. Histopathology shows a lack of myelin in the affected white matter, variably interpreted as hypomyelination or demyelination. To increase our insight into the nature of the pathology leading to the MR imaging findings in Alexander disease, we applied serial MR imaging, spectroscopy, magnetization t...

  2. Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matter

    Energy Technology Data Exchange (ETDEWEB)

    Voorn, J.P. van der [VU University Medical Center, Department of Child Neurology, Amsterdam (Netherlands); VU University Medical Center, Department of Pathology, Amsterdam (Netherlands); Pouwels, Petra J.W. [VU University Medical Center, Department of Physics and Medical Technology, Amsterdam (Netherlands); Salomons, Gajja S. [VU University Medical Center, Department of Clinical Chemistry (Metabolic Unit), Amsterdam (Netherlands); Barkhof, Frederik [VU University Medical Center, Department of Radiology, Amsterdam (Netherlands); Knaap, Marjo S. van der [VU University Medical Center, Department of Child Neurology, Amsterdam (Netherlands)

    2009-10-15

    Alexander disease is a rare disorder of the central nervous system with characteristic symmetric white matter abnormalities with frontal predominance on magnetic resonance (MR) images. Histopathology shows a lack of myelin in the affected white matter, variably interpreted as hypomyelination or demyelination. To increase our insight into the nature of the pathology leading to the MR imaging findings in Alexander disease, we applied serial MR imaging, spectroscopy, magnetization transfer (MT) imaging (MTI), and diffusion tensor imaging (DTI) in six patients with juvenile Alexander disease. The MR imaging protocol comprised T1- and T2-weighted spin echo images and fluid-attenuated inversion recovery images. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), and MT ratio (MTR) maps were generated, and MR spectroscopy concentrations were quantified for several metabolites. MR imaging showed similar cerebral white matter abnormalities in all patients, with only minor increase on prolonged follow-up, despite sometimes serious clinical progression. MR spectroscopy showed highly elevated levels of myo-inositol, lactate, and choline-containing compounds and decreased total N-acetyl-aspartate and N-acetyl-aspartyl-glutamate levels in the abnormal white matter. High values of ADC were observed, and both FA and MTR were attenuated. The sequential MR imaging findings in Alexander disease provide strong evidence against active demyelination as sole explanation for the underlying pathology. An alternative explanation for our spectroscopic, DTI, and MTI findings - which would suggest demyelination - could be hyperplasia and hypertrophy of astrocytes, as seen in low grade gliomas. (orig.)

  3. Alexander disease with mild dorsal brainstem atrophy and infantile spasms.

    Science.gov (United States)

    Torisu, Hiroyuki; Yoshikawa, Yoko; Yamaguchi-Takada, Yui; Yano, Tamami; Sanefuji, Masafumi; Ishizaki, Yoshito; Sawaishi, Yukio; Hara, Toshiro

    2013-05-01

    We present the case of a Japanese male infant with Alexander disease who developed infantile spasms at 8 months of age. The patient had a cluster of partial seizures at 4 months of age. He presented with mild general hypotonia and developmental delay. Macrocephaly was not observed. Brain magnetic resonance imaging (MRI) findings fulfilled all MRI-based criteria for the diagnosis of Alexander disease and revealed mild atrophy of the dorsal pons and medulla oblongata with abnormal intensities. DNA analysis disclosed a novel heterozygous missense mutation (c.1154 C>T, p.S385F) in the glial fibrillary acidic protein gene. At 8 months of age, tonic spasms occurred, and electroencephalography (EEG) revealed hypsarrhythmia. Lamotrigine effectively controlled the infantile spasms and improved the abnormal EEG findings. Although most patients with infantile Alexander disease have epilepsy, infantile spasms are rare. This comorbid condition may be associated with the distribution of the brain lesions and the age at onset of Alexander disease.

  4. Alexander disease as a cause of nocturnal vomiting in a 7-year-old girl

    International Nuclear Information System (INIS)

    Alexander disease is a rare form of leukodystrophy with a highly variable clinical course. Occasionally night-time nausea and vomiting are the first symptoms of juvenile Alexander disease. A 7-year-old girl had recurrent night-time vomiting and her growth and weight gain had deteriorated after her sixth birthday. Cranial MRI demonstrated two small, symmetrical focal areas of abnormally high signal intensity in the dorsal medulla oblongata on T2-W and FLAIR images. These were suggestive of juvenile Alexander disease, and subsequent sequencing of the glial fibrillary acidic protein (GFAP) gene revealed a heterogeneous missense mutation in the GFAP gene in exon 6. Alexander disease should be considered in young patients with atypical anorexia nervosa-type symptoms. (orig.)

  5. Alexander disease as a cause of nocturnal vomiting in a 7-year-old girl

    Energy Technology Data Exchange (ETDEWEB)

    Niinikoski, Harri [University of Turku, Department of Paediatrics, Turku (Finland); Haataja, Leena [University of Turku, Department of Paediatrics, Turku (Finland); University of Turku, Department of Pediatric Neurology, Turku (Finland); Brander, Antti [University of Tampere, Department of Radiology, Tampere (Finland); Valanne, Leena [University of Helsinki, Department of Radiology, Helsinki (Finland); Blaser, Susan [Hospital for Sick Children, Department of Radiology, Toronto (Canada)

    2009-08-15

    Alexander disease is a rare form of leukodystrophy with a highly variable clinical course. Occasionally night-time nausea and vomiting are the first symptoms of juvenile Alexander disease. A 7-year-old girl had recurrent night-time vomiting and her growth and weight gain had deteriorated after her sixth birthday. Cranial MRI demonstrated two small, symmetrical focal areas of abnormally high signal intensity in the dorsal medulla oblongata on T2-W and FLAIR images. These were suggestive of juvenile Alexander disease, and subsequent sequencing of the glial fibrillary acidic protein (GFAP) gene revealed a heterogeneous missense mutation in the GFAP gene in exon 6. Alexander disease should be considered in young patients with atypical anorexia nervosa-type symptoms. (orig.)

  6. Samuel Alexander Kinnier Wilson. Wilson's disease, Queen Square and neurology.

    Science.gov (United States)

    Broussolle, E; Trocello, J-M; Woimant, F; Lachaux, A; Quinn, N

    2013-12-01

    This historical article describes the life and work of the British physician Samuel Alexander Kinnier Wilson (1878-1937), who was one of the world's greatest neurologists of the first half of the 20th century. Early in his career, Wilson spent one year in Paris in 1903 where he learned from Pierre-Marie at Bicêtre Hospital. He subsequently retained uninterrupted links with French neurology. He also visited in Leipzig the German anatomist Paul Flechsig. In 1904, Wilson returned to London, where he worked for the rest of his life at the National Hospital for the Paralysed and Epileptic (later the National Hospital for Nervous Diseases, and today the National Hospital for Neurology and Neurosurgery) in Queen Square, and also at Kings' College Hospital. He wrote on 'the old motor system and the new', on disorders of motility and muscle tone, on the epilepsies, on aphasia, apraxia, tics, and pathologic laughing and crying, and most importantly on Wilson's disease. The other objective of our paper is to commemorate the centenary of Wilson's most important work published in 1912 in Brain, and also in Revue Neurologique, on an illness newly recognized and characterized by him entitled "Progressive lenticular degeneration, a familial nervous disease associated with liver cirrhosis". He analyzed 12 clinical cases, four of whom he followed himself, but also four cases previously published by others and a further two that he considered in retrospect had the same disease as he was describing. The pathological profile combined necrotic damage in the lenticular nuclei of the brain and hepatic cirrhosis. This major original work is summarized and discussed in the present paper. Wilson not only delineated what was later called hepato-lenticular degeneration and Wilson's disease, but also introduced for the first time the terms extrapyramidal syndrome and extrapyramidal system, stressing the role of the basal ganglia in motility. The present historical work emphasizes the special

  7. Infantile Refsum disease: serial evaluation with MRI.

    Science.gov (United States)

    Cakirer, Sinan; Savas, Mahmut R

    2005-02-01

    Refsum disease is a rare metabolic disorder, which is characterized by the accumulation of phytanic acid in the blood and tissues, including the brain. A variant of this condition that occurs in young children is called infantile Refsum disease. The MRI findings of symmetrical signal change involving the corticospinal tracts, cerebellar dentate nuclei, and corpus callosum are characteristic. We report the serial MRI findings of a child with this rare metabolic disorder.

  8. Infantile Refsum disease: serial evaluation with MRI

    Energy Technology Data Exchange (ETDEWEB)

    Cakirer, Sinan; Savas, Mahmut R. [Sisli Etfal Hospital, Neuroradiology Section, Department of Radiology, Istanbul (Turkey)

    2005-02-01

    Refsum disease is a rare metabolic disorder, which is characterized by the accumulation of phytanic acid in the blood and tissues, including the brain. A variant of this condition that occurs in young children is called infantile Refsum disease. The MRI findings of symmetrical signal change involving the corticospinal tracts, cerebellar dentate nuclei, and corpus callosum are characteristic. We report the serial MRI findings of a child with this rare metabolic disorder. (orig.)

  9. Phenotypic Conversions of “Protoplasmic” to “Reactive” Astrocytes in Alexander Disease

    OpenAIRE

    Sosunov, Alexander A.; Guilfoyle, Eileen; Wu, Xiaoping; Guy M McKhann; Goldman, James E.

    2013-01-01

    Alexander Disease (AxD) is a primary disorder of astrocytes, caused by heterozygous mutations in GFAP, which encodes the major astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). Astrocytes in AxD display hypertrophy, massive increases in GFAP, and the accumulation of Rosenthal fibers, cytoplasmic protein inclusions containing GFAP and small heat shock proteins. To study the effects of GFAP mutations on astrocyte morphology and physiology we have examined hippocam...

  10. GFAP expression as an indicator of disease severity in mouse models of Alexander disease

    Directory of Open Access Journals (Sweden)

    Albee Messing

    2013-03-01

    Full Text Available AxD (Alexander disease is a rare disorder caused by heterozygous mutations in GFAP (glial fibrillary acidic protein resulting in accumulation of the GFAP protein and elevation of Gfap mRNA. To test whether GFAP itself can serve as a biomarker of disease status or progression, we investigated two independent measures of GFAP expression in AxD mouse models, one using a genetic reporter of promoter activity and the other quantifying GFAP protein directly in a manner that could also be employed in human studies. Using a transgenic reporter line that expresses firefly luciferase under the control of the murine Gfap promoter (Gfap-luc, we found that luciferase activity reflected the regional CNS (central nervous system variability of Gfap mRNA in Gfap+/+ mice, and increased in mice containing a point mutation in Gfap that mimics a common human mutation in AxD (R239H in the human sequence, and R236H in the murine sequence. In a second set of studies, we quantified GFAP protein in CSF (cerebrospinal fluid taken from three different AxD mouse models and littermate controls. GFAP levels in CSF were increased in all three AxD models, in a manner corresponding to the concentrations of GFAP in brain. These studies demonstrate that transactivation of the Gfap promoter is an early and sustained indicator of the disease process in the mouse. Furthermore, GFAP in CSF serves as a potential biomarker that is comparable between mouse models and human patients.

  11. Serial MR imaging in Creutzfeldt-Jakob disease

    Energy Technology Data Exchange (ETDEWEB)

    Uchino, A.; Hata, H.; Ohno, M. (Kyushu Rosai Hospital, Kitakyushu (Japan). Dept. of Radiology); Yoshinaga, M.; Shiokawa, O. (Kyushu Rosai Hospital, Kitakyushu (Japan). Stroke Care Unit)

    1991-08-01

    Serial magnetic resonance (MR) imagings of two autopsied patients with Creutzfeldt-Jakob disease (CJD) are presented. Both patients showed a dramatic progression of brain atrophy. The initial MR imagings were, however, interpreted as normal except for localized mild cortical atrophy in one patient. When a normal MR image is obtained in a demented middle-aged or aged patient, CJD may still need to be ruled out: follow up MR imaging may be useful. (orig.).

  12. Alexander Fleming

    Institute of Scientific and Technical Information of China (English)

    李琳

    2006-01-01

    Alexander Fleming was born in a remote, rural part of Scotland. After completing school he was employed by a shipping firm, though he didn’t much like it. In 1900, when the Boer War broke out between the United Kingdom and its colonies in southern Africa, Fleming and two brothers joined a Scottish regiment, which turned out to be as much a sporting club as anything. Soon after this, he got a legacy of 250 pounds from his uncle and decided to study medicine.

  13. Serial computed tomography findings in Creutzfeldt-Jakob disease

    Energy Technology Data Exchange (ETDEWEB)

    Schlenska, G.K.; Walter, G.F.

    1989-09-01

    Serial CT investigations of 3 patients with histologically confirmed Creutzfeldt-Jakob disease revealed persisting slight brain atrophy to progressive extreme atrophy corresponding to the absolute, not the individual duration of illness. No correlation was observed between CT findings and the patients condition or electroencephalographic results. In one case with a duration of about 16 months and a terminal brain weight of 750 g a massive bilateral, later unilateral subdural hygroma appeared which probably was caused by retraction of the brain showing an enormous atrophy. (orig.).

  14. Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic.

    Science.gov (United States)

    Boczek, Nicole J; Sigafoos, Ashley N; Zimmermann, Michael T; Maus, Rachel L; Cousin, Margot A; Blackburn, Patrick R; Urrutia, Raul; Clark, Karl J; Patterson, Marc C; Wick, Myra J; Klee, Eric W

    2016-09-01

    A de novo GFAP variant, p.R376W, was identified in a child presenting with hypotonia, developmental delay, and abnormal brain MRI. Following the 2015 ACMG variant classification guidelines and the functional studies showing protein aggregate formation in vitro, p.R376W should be classified as a pathogenic variant, causative for Alexander disease.

  15. Serial CT scans and Menkes' kinky hair disease

    Energy Technology Data Exchange (ETDEWEB)

    Nakada, Eizo; Kameyama, Junji; Yoshimitsu, Hajime; Mori, Mikio; Tanaka, Mutsuo; Yoshimitsu, Kazunori.

    1988-02-01

    Menkes' kinky hair disease is a sex-linked recessive disorder of copper metabolism, characterized by progressive psychomotor deterioration, seizures, and peculiar hair structure. We examined serial CT scans of patients with this disease. A 2,210-g male infant was delivered after an uneventful gestation of 36 weeks. His one-minute Apgar score was 9. His uncle had died at 1 year of age. His first cousin was also diagnosed as having Menkes' kinky hair disease when our patient was 2 years old. Shortly after birth he had mild respiratory distress. At 5 days of age, he developed setting-sun signs. The first CT scan, at 10 days of age, revealed mild posterior fossa hemorrhages. At 3 months of age, myoclonic seizures began, and the CT scan revealed subdural effusion and mild brain atrophy. The seizures were controllable by using phenobarbital, valproic acid, and nitrazepam. He did not follow light or a fixate, but the fundi were normal. He was diffusely hypotonic. At 9 months of age, the seizures became uncontrollable. The CT scans at 15 and 31 months of age showed subdural hemorrhage and/or brain atrophy. At 15 months of age, the serum copper level was 42 ..mu.. g/dl, while the serum ceruloplasmin level was 3.2 mg/dl. He exhibited severe developmental failure. At 4 years of age, he died.

  16. Computing the Alexander Polynomial Numerically

    DEFF Research Database (Denmark)

    Hansen, Mikael Sonne

    2006-01-01

    Explains how to construct the Alexander Matrix and how this can be used to compute the Alexander polynomial numerically.......Explains how to construct the Alexander Matrix and how this can be used to compute the Alexander polynomial numerically....

  17. [Samuel Alexander Kinnier Wilson].

    Science.gov (United States)

    Kikuchi, Raita

    2014-11-01

    Samuel Alexander Kinnier Wilson is considered a pioneer in extrapyramidal system research largely due to his dissertation on progressive lenticular degeneration, later known as "Wilson's Disease". His concept of neurological symptomatology was based on the clinical observations of Pierre Marie, Joseph Babinski and John Hughlings Jackson, who he observed when he was young. To keep focusing on the nature of actual symptoms while performing medical examinations is the essence of neurological symptomatology, which in turn form the spirit of neurology. This paper will discuss major events in Wilson's later life that would explain how his basic idea for neurological symptomatology was eventually formed. PMID:25407062

  18. Serial MR findings of metaphyseal cyst in Legg-Calve-Perthes disease: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Chang Min; Na, Jae Boem; Moon, Haeng Jin [Gyeongsang National Univ., College of Mdicine, Chinju (Korea, Republic of)

    2001-11-01

    Metaphyseal cysts are common findings in Lee-Calve-Perthes(LCP) disease, though usually disappear within 6-12 months several studies have described the MR imaging findings of these cysts, though serial MRI findings have not been documented. In this report, therefore, we report the serial MRI results of metaphyseal cyst in LCP patients.

  19. Serial measurements of high-sensitivity cardiac troponin T after exercise stress test in stable coronary artery disease

    DEFF Research Database (Denmark)

    Axelsson, Anna; Ruwald, Martin Huth; Dalsgaard, Morten;

    2013-01-01

    The aim was to assess serial measurements of high-sensitivity cardiac troponin T (hs-cTNT) post-exercise in patients with stable coronary artery disease (CAD).......The aim was to assess serial measurements of high-sensitivity cardiac troponin T (hs-cTNT) post-exercise in patients with stable coronary artery disease (CAD)....

  20. Memorial Alexander Center

    Directory of Open Access Journals (Sweden)

    AECK Associates, Arquitectos

    1958-05-01

    Full Text Available En Atlanta, el Instituto Tecnológico de Georgia acaba de ampliar sus instalaciones deportivas, construyendo el Alexander Memorial Center. Consta este nuevo Centro de dos edificios: una pista de baloncesto cubierta y un edificio anejo con vestuarios, duchas, una pista de entrenamiento, equipos técnicos y la emisora de radio Georgia Tech W. G. S. T.

  1. Computed tomography of neurodegenerative disease in childhood. Serial CT findings and their diagnostic values

    Energy Technology Data Exchange (ETDEWEB)

    Kataoka, Kenkichi; Nakagawa, Yoshihiro; Hojo, Hiroatsu

    1984-12-01

    Serial computed tomographic scans were performed on seven children with neurodegenerative disorders. In two cases of white-matter diseases (Krabbe's disease and metachromatic leukodystrophy), diffuse, low-density lesions of white matter were visible in the early stage of the diseases. In one case of adrenoleukodystrophy, regional low-density lesions of the white matter around the posterior horns and peculiar high-density strip lesions were visible in the early stage. In two cases of storage-type gray-matter diseases (Tay-Sachs' and infantile Gaucher's disease), there were no abnormalities in the early stage, but diffuse cortical atrophies in the late stage. In one case of Leigh's disease, there were small, low-density lesions of the basal ganglia and multiple low-density lesions of the gray matter in the early stage. In one case of subacute sclerosing panencephalitis, there were no abnormalities in the early stage, but small, low-density lesions of the basal ganglia and diffuse cerebral atrophies in the late stage. Diagnostic values were recognized dominantly in two cases of adrenoleukodystrophy and Leigh's disease. In the other cases, however, serial CT scans were useful in the diagnostic process. (author).

  2. A canine orthologue of the human GFAP c.716G>A (p.Arg239His) variant causes Alexander disease in a Labrador retriever.

    Science.gov (United States)

    Van Poucke, Mario; Martlé, Valentine; Van Brantegem, Leen; Ducatelle, Richard; Van Ham, Luc; Bhatti, Sofie; Peelman, Luc J

    2016-06-01

    Alexander disease (AxD) is a fatal neurodegenerative disorder of astrocyte dysfunction in man, for which already a number of causal variants are described, mostly de novo dominant missense variants in the glial fibrillary acidic protein (GFAP). A similar disorder was already phenotypically described in animals but without the identification of causal variants. We diagnosed a Labrador retriever with a juvenile form of AxD based on clinical (tetraparesis with spastic front limbs mimicking 'swimming puppy syndrome') and pathological (the detection of GFAP containing Rosenthal fibers in astrocytes) features. In order to identify a causal variant, the coding sequences of the four detected GFAP transcript variants (orthologues from human transcript variants α, γ, δ/ɛ and κ) were sequenced. From the five detected variants, a heterozygous c.719G>A nucleotide substitution resulting in a p.Arg240His substitution was considered to be causal, because it is orthologous to the heterozygous de novo dominant c.716G>A (p.Arg239His) hotspot variant in man, proven to cause a severe phenotype. In addition, the variant was not found in 50 unrelated healthy Labrador retrievers. Because the condition in dogs is morphologically similar to man, it could be a promising animal model for further elucidating the genotype/phenotype correlation in order to treat or prevent this disease. PMID:26486469

  3. Characterizing the molecular basis of attenuation of Marek’s disease virus via in vitro serial passage

    Science.gov (United States)

    Marek’s disease (MD) is a lymphoproliferative disease of chickens caused by the oncogenic Gallid herpesvirus 2, commonly known as Marek’s disease virus (MDV). MD vaccines, the primary control method, are often generated by repeated in vitro serial passage of this highly cell-associated virus to atte...

  4. Adult-onset Alexander disease with typical "tadpole" brainstem atrophy and unusual bilateral basal ganglia involvement: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Sakoe Kumi

    2010-04-01

    Full Text Available Abstract Background Alexander disease (ALX is a rare neurological disorder characterized by white matter degeneration and cytoplasmic inclusions in astrocytes called Rosenthal fibers, labeled by antibodies against glial fibrillary acidic protein (GFAP. Three subtypes are distinguished according to age at onset: infantile (under age 2, juvenile (age 2 to 12 and adult (over age 12. Following the identification of heterozygous mutations in GFAP that cause this disease, cases of adult-onset ALX have been increasingly reported. Case Presentation We present a 60-year-old Japanese man with an unremarkable past and no family history of ALX. After head trauma in a traffic accident at the age of 46, his character changed, and dementia and dysarthria developed, but he remained independent. Spastic paresis and dysphagia were observed at age 57 and 59, respectively, and worsened progressively. Neurological examination at the age of 60 revealed dementia, pseudobulbar palsy, left-side predominant spastic tetraparesis, axial rigidity, bradykinesia and gaze-evoked nystagmus. Brain MRI showed tadpole-like atrophy of the brainstem, caused by marked atrophy of the medulla oblongata, cervical spinal cord and midbrain tegmentum, with an intact pontine base. Analysis of the GFAP gene revealed a heterozygous missense mutation, c.827G>T, p.R276L, which was already shown to be pathogenic in a case of pathologically proven hereditary adult-onset ALX. Conclusion The typical tadpole-like appearance of the brainstem is strongly suggestive of adult-onset ALX, and should lead to a genetic investigation of the GFAP gene. The unusual feature of this patient is the symmetrical involvement of the basal ganglia, which is rarely observed in the adult form of the disease. More patients must be examined to confirm, clinically and neuroradiologically, extrapyramidal involvement of the basal ganglia in adult-onset ALX.

  5. Alexander Duals of Multipermutohedron Ideals

    Indian Academy of Sciences (India)

    Ajay Kumar; Chanchal Kumar

    2014-02-01

    An Alexander dual of a multipermutohedron ideal has many combinatorial properties. The standard monomials of an Artinian quotient of such a dual correspond bijectively to some -parking functions, and many interesting properties of these Artinian quotients are obtained by Postnikov and Shapiro (Trans. Am. Math. Soc. 356 (2004) 3109–3142). Using the multigraded Hilbert series of an Artinian quotient of an Alexander dual of multipermutohedron ideals, we obtained a simple proof of Steck determinant formula for enumeration of -parking functions. A combinatorial formula for all the multigraded Betti numbers of an Alexander dual of multipermutohedron ideals are also obtained.

  6. Alexander Lowen: An Energetic Man.

    Science.gov (United States)

    Good, Glenn E.; Rabinowitz, Fredric E.

    1992-01-01

    Presents interview with Alexander Lowen, prominent psychotherapist, who discusses his personal and professional development, as well as the evolution of bioenergetic analysis. Includes a list of suggested readings by Lowen. (Author/NB)

  7. Alexander: From Invasion to Absorption

    Directory of Open Access Journals (Sweden)

    محمود امیدسالار

    2013-01-01

    Full Text Available The character of Alexander is a mingling of good and bad features; however, there is a kind of illogical anti- Alexander attitude in the studies of the Shāh-nāmeh which is in contrast with the popularity of Alexander in both oral tradition and formal literature. In the Shāh-nāmeh, Alexander is the son of Darab and a descendant of Iranian kings and is entitled to the crown. His story is narrated in about 2408 couplets in detail. The Shāh-nāmeh episode of Alexander has been interpreted by Nöldeke and others as a “face-saving” stratagem aimed at lessening the dishonor of defeat by an alien invader. Although the idea that Iranians may have concocted this story in order to soften the blow of foreign conquest is plausible, this plausibility is not the same thing as proof. A similar story according to which Alexander is the son of an Egyptian king exists in Egyptian versions of the story of Alexander. Since these similar tales existed among two peoples whom Alexander vanquished and then sought to conciliate, it could be equally assumed if these two tales were made up by Alexander’s own propagandists. Alternatively, these tales may have been fabricated by the Greco-Persian and Greco-Egyptian nobilities of the post-conquest societies of Iran and Egypt which sought to bridge the gap between the worlds of their fathers with those of their mothers. All of these scenarios, which are not necessarily mutually exclusive, are plausible. The article discusses these different interpretations by drawing on the known historical details of Alexander’s invasion of Iran.

  8. Leukocyte scintigraphy: correlation of serial scintigraphic findings and clinical progression of inflammatory bowel disease

    Energy Technology Data Exchange (ETDEWEB)

    Ho, Y.; Kelly, M.J.; Kaliff, V. [Alfred Hospital, Prahan, VIC (Australia). Department of Nuclear Medicine

    1997-12-01

    Full text: This study was performed (a) to determine whether the clinical progress of individual patients with inflammatory bowel disease mirrored changes in leukocyte scans, and (b) to assess the reasons for significant discrepancies. Two nuclear medicine physicians reviewed 44 white cell scans in 20 consecutive patients (4 males, 18 females) who were referred for two or more leukocyte scans (using either the {sup 111}In Oxine or {sup 99m}Tc HMPAO labelling methods) by three gastroenterologists between 1 January 1992 and 1 June 1996. The sequential scanpairs (range 2-18 months apart) were classified by consensus reading as showing no change, more severe or less severe disease. Questionnaires were sent to the referring gastroenterologists to determine whether the overall clinical status of each patient was unchanged, better or worse in the interval between the two scans. There was complete agreement between clinical and scintigraphic assessment in 45% (10/22) of the study pairs. Review of responses of the three individual gastroenterologists showed a wide range of agreement (4/4, 4/5, 2/13). Review of data showed that most disagreement was based on subjective clinical assessment, and hence of uncertain significance. In two patients, however, potentially preventable false negative leukocyte scans occurred in patients with active proctitis. This may be overcome by rigorous attention to ensure complete emptying of radioactivity from the bladder when {sup 99m}Tc HMPAO is used. It was concluded that serial leukocyte scans add to clinical assessment but careful technique is needed to avoid false negative scans in the rectum

  9. Sir Alexander Fleming: Scottish researcher who discovered penicillin.

    Science.gov (United States)

    Ligon, B Lee

    2004-01-01

    The discovery and development of penicillin changed the entire direction of approaches to treating infectious diseases and saved the lives of millions of people. Indeed, the development of penicillin was a watershed event in the battle against infectious diseases, and the individual who discovered it, Sir Alexander Fleming, remains a prominent individual in the annals of medical history. This article focuses primarily on the personal life of Alexander Fleming, an individual who had a remarkable diversity of interests and who made many contributions to science and medicine.

  10. Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia. Assessment with serial CT

    International Nuclear Information System (INIS)

    Objective. To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods. Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HRCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results. On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean±SD extent, 30±16%) and irregular lines (mean±SD extent, 17±7%) and 10 patients had honeycombing (mean±SD extent, 10±6%). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean±SD extent, 51±26%), 5 patients had irregular linear opacities (mean±SD extent, 5±5%), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p2 test). Conclusion. In patients with UIP, areas of ground-glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment. (authors)

  11. Serial position effects scoring in the assessment of memory in Alzheimer's disease and major depression

    NARCIS (Netherlands)

    Bemelmans, Karel Jozef

    2009-01-01

    The objective of this thesis was to validate serial position effects (SPE’S) scoring in the Rey Auditory Verbal Learning Test (RAVLT). The RAVLT is a much used clinical method for assessing memory performance, but the method of scoring obfuscates that two memory processes underlie free recall. This

  12. Representations of Knot Groups and Twisted Alexander Polynomials

    Institute of Scientific and Technical Information of China (English)

    Xiao Song LIN

    2001-01-01

    We present a twisted version of the Alexander polynomial associated with a matrix representation of the knot group. Examples of two knots with the same Alexander module but differenttwisted Alexander polynomials are given.

  13. Serial and static brain radioangiogram in diagnosis of carotid disease: value, indication and limits by comparative study with EEG, Doppler study and cerebral arteriography

    International Nuclear Information System (INIS)

    Value, indication and limits of serial and static brain radioangiogram in carotid disease are studied comparatively with EEG, Doppler study and cerebral arteriograhy. The isotopic study shows the occlusion and its consequences on middle cerebral artery and cerebral hemisphere. The 'Hot-Nose' sign is rarely seen, but then with large focal abnormalities. In 20% of studied cases, isotopic study provides information about the efficiency of suppleance circulation or the existence of a blood derivation. The value of serial and static scintigraphy deserves it a better place among the non invasive diagnosis method of carotid disease

  14. Alexander the Great and West Nile Virus Encephalitis

    OpenAIRE

    Marr, John S.; Calisher, Charles H.

    2003-01-01

    Alexander the Great died in Babylon in 323 BC. His death at age 32 followed a 2-week febrile illness. Speculated causes of death have included poisoning, assassination, and a number of infectious diseases. One incident, mentioned by Plutarch but not considered by previous investigators, may shed light on the cause of Alexander’s death. The incident, which occurred as he entered Babylon, involved a flock of ravens exhibiting unusual behavior and subsequently dying at his feet. The inexplicable...

  15. Did Alexander the Great read Xenophon?

    OpenAIRE

    McGroarty, Kieran

    2006-01-01

    It has been assumed by writers, ancient and modern, that Xenophon’s literary output had a direct influence on Alexander the Great. But is there any evidence to prove that it did? In spite of the paucity of references to Xenophon in the surviving Alexander sources, many writers, both ancient and modern, have no doubts concerning the influence of Xenophon’s writings on Alexander. An extreme position is suggested by Eunapius, the sophist and historian born at Sardis c. AD 345, when he says in hi...

  16. A psychoanalytic study of Alexander the Great.

    Science.gov (United States)

    Thomas, K R

    1995-12-01

    The purpose of this paper was to demonstrate how Freudian concepts such as the Oedipus complex, castration anxiety, fear of loss of love, the psychosexual stages of development, and the tripartite structure of personality can be used to understand the life and achievements of Alexander the Great. To accomplish this purpose, specific incidents, myths, and relationships in Alexander's life were analyzed from a Freudian psychoanalytic perspective. Green (1991), in his recent biography of Alexander, has questioned the merit of using Freudian concepts to understand Alexander's character. In fact, he stated specifically: If he (Alexander) had any kind of Oedipus complex it came in a poor second to the burning dynastic ambition which Olympias so sedulously fostered in him; those who insist on his psychological motivation would do better to take Adler as their mentor than Freud (p.56). Later, in the concluding section of his book, Green (1991, pp. 486-487) discounted Freudian interpretations of Alexander's distaste for sex, the rumors of his homosexual liaisons, his partiality for middle-aged or elderly ladies, and the systematic domination of his early years by Olympias as little more than the projected fears and desires of the interpreters. And again, an Adlerian power-complex paradigm was suggested as the preferable theoretical framework to use. Green's argument was based primarily on an exchange, reported originally by Plutarch, which took place between Alexander and Philip prior to Alexander's tutorship with Aristotle. Purportedly, Philip enjoined his son to study hard and pay close attention to all Aristotle said "so that you may not do a great many things of the sort that I am sorry I have done." At this point, Alexander "somewhat pertly" took Philip to task "because he was having children by other women besides his wife." Philip's reply was: "Well then, if you have many competitors for the kingdom, prove yourself honorable and good, so that you may obtain the

  17. Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

    Science.gov (United States)

    Krombholz, Christopher Felix; Aumann, Konrad; Kollek, Matthias; Bertele, Daniela; Fluhr, Silvia; Kunze, Mirjam; Niemeyer, Charlotte M; Flotho, Christian; Erlacher, Miriam

    2016-05-01

    Juvenile myelomonocytic leukemia is a clonal malignant disease affecting young children. Current cure rates, even with allogeneic hematopoietic stem cell transplantation, are no better than 50%-60%. Pre-clinical research on juvenile myelomonocytic leukemia is urgently needed for the identification of novel therapies but is hampered by the unavailability of culture systems. Here we report a xenotransplantation model that allows long-term in vivo propagation of primary juvenile myelomonocytic leukemia cells. Persistent engraftment of leukemic cells was achieved by intrahepatic injection of 1×10(6) cells into newborn Rag2(-/-)γc(-/-) mice or intravenous injection of 5×10(6) cells into 5-week old mice. Key characteristics of juvenile myelomonocytic leukemia were reproduced, including cachexia and clonal expansion of myelomonocytic progenitor cells that infiltrated bone marrow, spleen, liver and, notably, lung. Xenografted leukemia cells led to reduced survival of recipient mice. The stem cell character of juvenile myelomonocytic leukemia was confirmed by successful serial transplantation that resulted in leukemia cell propagation for more than one year. Independence of exogenous cytokines, low donor cell number and slowly progressing leukemia are advantages of the model, which will serve as an important tool to research the pathophysiology of juvenile myelomonocytic leukemia and test novel pharmaceutical strategies such as DNA methyltransferase inhibition. PMID:26888021

  18. Clinical and genetic study of twelve Chinese patients with Alexander disease%亚历山大病12例中国患儿临床及遗传学研究

    Institute of Scientific and Technical Information of China (English)

    臧莉莉; 吴晔; 王静敏; 顾强; 姜玉武; 高志杰; 杨艳玲; 肖江喜; 吴希如

    2012-01-01

    Objective To delineate the phenotype and genotype characteristics in 12 Chinese children with Alexander disease ( AD),which is helpful for the molecular diagnosis and genetic counseling in China.Methods Clinical diagnosis of AD was based on MRI criteria proposed by van der Knaarp in 2001.Included AD patients were followed up for 0.50-3.67 years.Mutations in GFAP were detected by DNA sequencing.Results The 12 cases of AD were clinically diagnosed.Age of first visit was 4.87 years (0.75-12.00 years),with 3 type s of chief complaints:developmental delay in 3,recurrent seizures in 7,unable to walk after falling in 2.Average head circumference was 52.34 cm (44-58 cm),which larger than age-matched average by 6.45% ( 1.80% -13.95% ).On the first visit,scaling according to Gross motor functional classification system ( GMFCS ) was performed,with GMFCS Ⅰ in 8,Ⅱ in 3,V in 1.Mild to severe cognitive dysfunction were found in 8,and seizures in 11 cases.The 12 patients were followed up for 0.50-3.67 years,their motor and cognitive function remained stable. Episodic aggravations provoked by fever or falling were observed in 5 cases (41.67%). Heterozygous missense mutations of GFAP were detected in 12 patients.All mutations were de novo; 3 out of 10 mutations identified were novel.R79 and P239 were hot mutations,which was consistent with previous reports.Mutations were located in exon 1 in 8 cases.Conclusions The phenotype in these patients is characterized by slower progression compared with reports from other population and high incidence of seizures.And episodic aggravations provoked by fever or falling were more common.The genotype characteristics are consistent with previous reports.The results of this research expanded the number of patients with Alexander disease found to have GFAP coding mutations in China.%目的 了解12例中国亚历山大病(Alexander disease,AD)患儿的临床表型及遗传学特点,为在国内开展该病的分子诊断及

  19. Disease: H00065 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00065 Alexander disease Alexander disease is a rare, but often fatal neurological ...ult forms. The characteristic neuropathological feature of all forms of Alexander's disease is the presence ...enthal fibers MeSH: D038261 OMIM: 203450 PMID:17498694 Quinlan RA, Brenner M, Goldman JE, Messing A. GFAP and its role in Alex... R, Gibbon T, Prescott AR, Brenner M, Quinlan RA The Alexander disease-causing gl... M TRH therapy in a patient with juvenile Alexander disease. Brain Dev 28:663-7 (

  20. A Metabiography of Alexander von Humboldt

    OpenAIRE

    Nicolaas A. Rupke

    2006-01-01

    Article in English.The author's recently published monograph on Alexander von Humboldt describes the multiple images of this great cultural icon. The book is a metabiographical study that shows how from the middle of the nineteenth century to the present day Humboldt has served as a nucleus of crystallisation for a variety of successive socio-political ideologies, each producing its own distinctive representation of him. The historiographical implications of this biographical diversity are p...

  1. "Most brilliant in judgment": Alexander the Great and Aristotle.

    Science.gov (United States)

    Lainas, Panagiotis; Panutsopulos, Dimitrios; Skandalakis, Panagiotis N; Zoras, Odysseas; Skandalakis, John E

    2005-03-01

    From historical sources, it is evident that Alexander the Great was indebted to one of his teachers, Aristotle of Stagira. It was the teaching of Aristotle that evoked all the nascent talents of young Alexander and turned him into a great man. Alexander was extremely interested in the secrets of medicine and considered it an art. The medical knowledge he acquired from Aristotle may have saved his life and the lives of his troops on many occasions. If Alexander did not possess medical knowledge and if his everyday life had not been so greatly influenced by medicine, he might never have been able to create his empire.

  2. Decreasing Serial Cost Sharing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Østerdal, Lars Peter

    The increasing serial cost sharing rule of Moulin and Shenker [Econometrica 60 (1992) 1009] and the decreasing serial rule of de Frutos [Journal of Economic Theory 79 (1998) 245] have attracted attention due to their intuitive appeal and striking incentive properties. An axiomatic characterization...... of the increasing serial rule was provided by Moulin and Shenker [Journal of Economic Theory 64 (1994) 178]. This paper gives an axiomatic characterization of the decreasing serial rule...

  3. Decreasing serial cost sharing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Østerdal, Lars Peter Raahave

    2009-01-01

    The increasing serial cost sharing rule of Moulin and Shenker (Econometrica 60:1009-1037, 1992) and the decreasing serial rule of de Frutos (J Econ Theory 79:245-275, 1998) are known by their intuitive appeal and striking incentive properties. An axiomatic characterization of the increasing serial...... rule was provided by Moulin and Shenker (J Econ Theory 64:178-201, 1994). This paper gives an axiomatic characterization of the decreasing serial rule....

  4. Twisted Alexander polynomials of hyperbolic knots

    CERN Document Server

    Dunfield, Nathan M; Jackson, Nicholas

    2011-01-01

    We study a twisted Alexander polynomial naturally associated to a hyperbolic knot in an integer homology 3-sphere via a lift of the holonomy representation to SL(2, C). It is an unambiguous symmetric Laurent polynomial whose coefficients lie in the trace field of the knot. It contains information about genus, fibering, and chirality, and moreover is powerful enough to sometimes detect mutation. We calculated this invariant numerically for all 313,209 hyperbolic knots in S^3 with at most 15 crossings, and found that in all cases it gave a sharp bound on the genus of the knot and determined both fibering and chirality. We also study how such twisted Alexander polynomials vary as one moves around in an irreducible component X_0 of the SL(2, C)-character variety of the knot group. We show how to understand all of these polynomials at once in terms of a polynomial whose coefficients lie in the function field of X_0. We use this to help explain some of the patterns observed for knots in S^3, and explore a potential...

  5. Serial color Doppler flow of uterine vasculature combined with serum beta-hCG measurements for improved monitoring of patients with gestational trophoblastic disease. A preliminary report.

    Science.gov (United States)

    Maymon, R; Schneider, D; Shulman, A; Bukowsky, I; Weinraub, Z

    1996-01-01

    Weekly serum beta-hCG measurements and transvaginal ultrasound scans coupled with color Doppler flow were performed on 8 patients with hydatidiform mole. Two patients later developed persistent trophoblastic disease, necessitating chemotherapy. The correlation coefficients between Doppler flow indices, systolic-diastolic (S/D) ratio and pulsatility index (PI) with log beta-hCG were -0.96 and -0.97, respectively. The weekly S/D and PI indices were plotted on an individual curve. Only the 2 patients who developed persistent gestational trophoblastic disease had PI index levels of < or = 1.5 as early as 2 weeks after molar evacuation. At that stage their serum beta-hCG levels were not different from some of the other patients. In this preliminary report, the regression of the disease could be reliably assessed by observing the changes in low resistance flow which paralleled the gradual decrements in serial beta-hCG levels. Thus, the contribution of this noninvasive imaging technique encourages the authors to further investigate Doppler flow monitoring among a larger sample of patients suffering from various gestational trophoblastic diseases.

  6. The Greek Phyllada and the Old Serbian Alexander Romance

    OpenAIRE

    Krzysztof Usakiewicz

    2015-01-01

    The Greek Phyllada and the Old Serbian Alexander RomanceThe texts presents chosen fragments of the Greek "Phyllada", or the story about Alexander the Great, and its Polish translation, with an introduction commenting the relation between the Greek and Serbian version of Alexader's gesta.

  7. The Alexander the First collection of the Lausanne Museum

    NARCIS (Netherlands)

    Minina, E.L.

    2004-01-01

    Study of written sources in archives sometimes allows to restore the history of collections. A good example is the Alexander the First collection. In 1819, de la Harpe had sent an Etruscan vase to Alexander I as a gift, and had received a collection of Russian minerals in return. Alexander’s collect

  8. Eigenvalue conjecture and colored Alexander polynomials

    CERN Document Server

    Mironov, A

    2016-01-01

    We connect two important conjectures in the theory of knot polynomials. The first one is the property Al_R(q) = Al_{[1]}(q^{|R|}) for all single hook Young diagrams R, which is known to hold for all knots. The second conjecture claims that all the mixing matrices U_{i} in the relation {\\cal R}_i = U_i{\\cal R}_1U_i^{-1} between the i-th and the first generators {\\cal R}_i of the braid group are universally expressible through the eigenvalues of {\\cal R}_1. Since the above property of Alexander polynomials is very well tested, this relation provides a new support to the eigenvalue conjecture, especially for i>2, when its direct check by evaluation of the Racah matrices and their convolutions is technically difficult.

  9. Simultaneously Cooperative, but Serially Antagonistic: A Neuropsychological Study of Diagonistic Dyspraxia in a Case of Marchiafava-Bignami Disease

    OpenAIRE

    Kazumi Hirayama; Kaori Tachibana; Nobuhito Abe; Hideaki Manabe; Takahisa Fuse; Tetsuro Tsukamoto

    2008-01-01

    We describe a patient with Marchiafava-Bignami disease who showed, in addition to signs of callosal interruption, a peculiar form of diagonistic dyspraxia. Unlike the typical diagonistic dyspraxia, both of the patient’s hands could simultaneously cooperate in a sequence of bimanual actions. More specifically, his right hand could start a commanded action with the cooperation of his left hand. However, once the action was completed, his left hand started an antagonistic action, undoing the res...

  10. Port Alexander, Alaska Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Port Alexander, Alaska Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  11. A Complex-Network Perspective on Alexander's Wholeness

    CERN Document Server

    Jiang, Bin

    2016-01-01

    The wholeness, conceived and developed by Christopher Alexander, is what exists to some degree or other in space and matter, and can be described by precise mathematical language. However, it remains mysterious and hard to grasp. This paper develops a complex network perspective on the wholeness to better understand the nature of order or beauty, and apply it into sustainable design. I bring together a set of complexity-science subjects such as complex networks, fractal geometry, and in particular underlying scaling hierarchy derived by head/tail breaks, in order to make Alexander's profound thoughts more accessible to design practitioners and complexity-science researchers. Through several case studies (some of which Alexander studied), I demonstrate that the complex-network perspective helps reduce the mystery of wholeness and brings new insights to Alexander's thoughts on the concept of wholeness or objective beauty in fine structures. The complex-network perspective enables us to see things in their whole...

  12. Leni Alexander Pollack (1924-2005

    Directory of Open Access Journals (Sweden)

    Raquel Bustos Valderrama

    2007-06-01

    Full Text Available El estudio de Leni Alexander Pollack, considerada la compositora nacional más importante del siglo XX, expande y profundiza nuestro conocimiento del aporte de la mujer a la creación musical chilena. En el presente trabajo las entrevistas personales fueron no sólo la fuente primaria para obtener los antecedentes biográficos iniciales, sino también una oportunidad para discutir y aclarar asuntos de estética, tendencias y estilo. Sobre estas bases se analizan tres obras específicas, consideradas como demarcatorias de la evolución de sus recursos creativos. El catálogo de sus obras es una muestra vívida de la gran versatilidad de la compositora en el libre uso de los parámetros musicales, como elementos básicos generadores de toda una obra y, a la vez, en las sugerencias que hace a los instrumentistas- intérpretes o a los actores de su hörspiel o "teatro para escuchar". En suma, sus composiciones y escritos académicos, a los que se agrega la difusión radial comentada de la música contemporánea en Chile y en el extranjero, confirman su calidad de representante itinerante y portavoz de la vanguardia musical del siglo XXLeni Alexander Pollack, has been considered the most important national female composer of the 20th century. The study of her musical composition has contributed to further our knowledge of women's contributions to musical creation in Chile. For the present paper, personal interviews were not only a primary source for the initial biographical information, but also an opportunity to discuss with the composer topics related to aesthetics, tendencies and style. Upon these bases, three specific works are analyzed, which are considered turning points in the evolution of her creative resources. The catalog of her work is a vivid demonstration of her versatility in the free use of musical parameters, which can be seen as basic element in the generation of complete works, as well as in the suggestions she offers to the

  13. ALEXANDER THE GREAT IN THE SEYAHATNAME OF EVLİYA ÇELEBİ

    OpenAIRE

    Avcı, İsmail

    2013-01-01

    Evliya Çelebi's Seyahatname, an unprecedented work of his lifetime travels throughout the Ottoman Empire mentions about four sovereigns who subjugated throughout the world. These sovereigns were Solomon, Alexander, Yanko bin Madyan and Buhtunnasr. Amongst them, Alexander is referred in the work of Evliya Çelebi as Zulkarneyn, Iskender-i Zulkarneyn, Iskender-i Kubra, Iskender-i Rumi, Iskender-i Yunan, Alexander, Feyleko Alexander, and Alexander the Son of Filkos and provided various aspects of...

  14. Serial action and perception

    NARCIS (Netherlands)

    Abrahamse, Elger Leander

    2010-01-01

    The central theme of this dissertation concerns the nature of (implicit) perceptual-motor sequence learning as studied in the serial reaction time (SRT) task. Convincing support exists in the literature for three forms of serial learning: perceptual learning (S-S associations), response-based learni

  15. Serial MRI in early Creutzfeldt-Jacob disease with a point mutation of prion protein at codon 180

    International Nuclear Information System (INIS)

    We report a 66-year-old woman with histologically diagnosed Creutzfeld-Jacob disease (CJD), followed with MRI from an early clinical stage. MRI demonstrated expansion of the high cortical signal on T2-weighted images, which differs from previous MRI reports of CJD. This patient followed an atypical clinical course: 16 months had passed before she developed akinetic mutism, and periodic sharp waves had not been detected on EEG after 2 years in spite of her akinetic mutism. Brain biopsy showed primary spongiform changes in the grey matter, and a point mutation of the prion protein gene at codon 180 was discovered using polymerase chain reaction direct sequencing and Tth 111 I cutting. This is the first case with the point mutation of the codon 180 variant with an atypical clinical course and characteristic MRI findings. (orig.)

  16. Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG-based analysis

    Directory of Open Access Journals (Sweden)

    Sanju P Joy

    2015-01-01

    Full Text Available Purpose: We studied the sleep macroarchitecture with polysomnography (PSG in drug naïve patients with Parkinson′s disease (PD and reassessed them following treatment with levodopa. Materials and Methods: This prospective hospital-based study included 15 patients with PD (age: 59 ± 11.2 years, duration of PD: 11.8 ± 12.3 months; and male: female (M:F = 11:4. They were assessed for demography, phenotype, modified Hoehn and Yahr staging (H & Y; Schwab and England and Activities of Daily Living (S and E ADL Scale; and Unified PDRating Scale (UPDRS. Sleep was assessed using Epworth Sleepiness Scale (ESS, Pittsburgh Sleep Quality Index (PSQI, and National Institute of Mental Health and Neurosciences (NIMHANS comprehensive sleep disorder questionnaire. They underwent overnight PSG at baseline and after13.3 ± 5.7 months of levodopa (440 mg/day. Results: Patients with PD had responded to levodopa as indicated by the significant improvement in UPDRS motor score in ON state compared to OFF state. Nocturnal sleep quality indices did not vary significantly, but the excessive daytime somnolence improved (P = 0.04 with levodopa. Sleep efficiency (P = 0.65, latency to sleep onset (P = 0.19, latency to stage 1 (P = 0.12, and duration of stage 1 (P = 0.55 had increased. Duration of ′awake in bed′ (P = 0.24, slow wave sleep (P = 0.29, and rapid eye movement (REM sleep (P = 0.24 decreased with treatment. Periodic leg movements (PLMs had reduced (P = 0.68 and mean oxygen saturation during sleep improved (P = 0.002. Surprisingly, snore index (P < 0.03 during sleep had increased with levodopa. Conclusions: Sleep alterations in PD occur even in early stages due to the disease process. There was improvement in most of the parameters of sleep macroarchitecture with levodopa.

  17. Alexander Lernet-Holenia und Maria Charlotte Sweceny

    OpenAIRE

    Dietz, Christopher

    2013-01-01

    Zentrum der vorliegenden Arbeit bildet die Edition des Briefwechsels zwischen dem österreichischen Schriftsteller Alexander Lernet-Holenia (1897-1976) und Maria Charlotte ("Lotte") Sweceny (geb. Stein, 1904-1956), Gesellschafterin des Wiener Verlags Manz, während der Jahre 1938 bis 1945. Ein einleitender Aufsatz bietet einen Forschungsüberblick, gibt den Inhalt der Briefe wieder und analysiert ihre Bedeutung für Biografie und Werk Alexander Lernet-Holenias. Auf die Transkripte der 154 Briefe ...

  18. Valuing the Numismatic Legacy of Alexander the Great

    OpenAIRE

    Taylor, J. Edward

    2007-01-01

    The conquests of Alexander III ("The Great") transformed the economic as well as political landscape of ancient Greece and Persia. It produced a prolific coinage, part of which survives today. This paper uses a hedonic price modeling approach to analyze auction prices of the major coin type of Alexander the Great. The findings make it possible to identify the effects of specific coin characteristics on realized auction prices, sellers' reservation prices (auction price estimates), discrepa...

  19. Simultaneously cooperative, but serially antagonistic: a neuropsychological study of diagonistic dyspraxia in a case of Marchiafava-Bignami disease.

    Science.gov (United States)

    Hirayama, Kazumi; Tachibana, Kaori; Abe, Nobuhito; Manabe, Hideaki; Fuse, Takahisa; Tsukamoto, Tetsuro

    2008-01-01

    We describe a patient with Marchiafava-Bignami disease who showed, in addition to signs of callosal interruption, a peculiar form of diagonistic dyspraxia. Unlike the typical diagonistic dyspraxia, both of the patient's hands could simultaneously cooperate in a sequence of bimanual actions. More specifically, his right hand could start a commanded action with the cooperation of his left hand. However, once the action was completed, his left hand started an antagonistic action, undoing the result, with the cooperation of his right hand. Once this countermanding action was completed, the original action started again. These antagonistic actions repeated themselves alternately unless he was restrained. The patient's diagonistic dyspraxia was apparent in only some bimanual actions, and he showed no diagonistic dyspraxia when performing voluntary actions; the antagonistic actions occurred in response to oral commands or by imitation. Magnetic resonance imaging showed symmetrical demyelination with partial necrosis in the genu, body, and anterior splenium of the corpus callosum. We speculate that the bimanual coordination is possible because part of the corpus callosum is intact, whereas the antagonistic actions may be caused by conflict between the two hemispheres due to interhemispheric disinhibition elicited by the demyelinated part of the corpus callosum. PMID:18641433

  20. Simultaneously Cooperative, but Serially Antagonistic: A Neuropsychological Study of Diagonistic Dyspraxia in a Case of Marchiafava-Bignami Disease

    Directory of Open Access Journals (Sweden)

    Kazumi Hirayama

    2008-01-01

    Full Text Available We describe a patient with Marchiafava-Bignami disease who showed, in addition to signs of callosal interruption, a peculiar form of diagonistic dyspraxia. Unlike the typical diagonistic dyspraxia, both of the patient’s hands could simultaneously cooperate in a sequence of bimanual actions. More specifically, his right hand could start a commanded action with the cooperation of his left hand. However, once the action was completed, his left hand started an antagonistic action, undoing the result, with the cooperation of his right hand. Once this countermanding action was completed, the original action started again. These antagonistic actions repeated themselves alternately unless he was restrained. The patient's diagonistic dyspraxia was apparent in only some bimanual actions, and he showed no diagonistic dyspraxia when performing voluntary actions; the antagonistic actions occurred in response to oral commands or by imitation. Magnetic resonance imaging showed symmetrical demyelination with partial necrosis in the genu, body, and anterior splenium of the corpus callosum. We speculate that the bimanual coordination is possible because part of the corpus callosum is intact, whereas the antagonistic actions may be caused by conflict between the two hemispheres due to interhemispheric disinhibition elicited by the demyelinated part of the corpus callosum.

  1. Alexander F. Chamberlain: a life's work.

    Science.gov (United States)

    Berkman, Julia M

    2005-01-01

    This article examines the life and work of Alexander Francis Chamberlain. Though he has received little attention since the early 1900s, the importance of this scholar should not be underestimated. Chamberlain made notable contributions to the body of knowledge in anthropology-a discipline that, at the time, was a combination of anthropological and psychological inquiry. His early work began with investigations into the cultures and languages of two Indian tribes indigenous to Canada and the northern United States and, within a few decades, positioned Chamberlain as the leading scholar in this domain. Beyond his ethnographic insights, Chamberlain queried the development of the child and wrote on the subject of childhood in world folklore. He concerned himself with a scope of worthwhile subjects ranging from linguistics to women's suffrage. No topic was out of range as all forms of human study addressed the need for seeing each group as a contributing force to humanity at large. Chamberlain emphasized that no single racial, ethnic, or religious group should be singled out as inherently superior to another, a belief far ahead of his time. This article is an attempt at drawing a picture of a man whose scholarly achievements and strength of character are captured in the depth and breadth of his writing. PMID:17549937

  2. CRNL library serials list

    International Nuclear Information System (INIS)

    A list of 1900 serial publications (periodicals, society transactions and proceedings, annuals and directories, indexes, newspapers, etc.) is presented with volumes and years held by the Main Library. This library is the largest in AECL as well as one of the largest scientific and technical libraries in North America, and functions as a Canadian resource for nuclear information. A main alphabetical list is followed by broad subject field lists representing research interests, and lists of abstract and index serials, general bibliographic serials, conference indexes, press releases, English translations, and original language journals

  3. Alexander quandle lower bounds for link genera

    CERN Document Server

    Benedetti, Riccardo

    2011-01-01

    We denote by Q_F the family of the Alexander quandle structures supported by finite fields. For every k-component oriented link L, every partition P of L into h:=|P| sublinks, and every labelling z of such a partition by the natural numbers z_1,...,z_n, the number of X-colorings of any diagram of (L,z) is a well-defined invariant of (L,P), of the form q^(a_X(L,P,z)+1) for some natural number a_X(L,P,z). Letting X and z vary in Q_F and among the labellings of P, we define a derived invariant A_Q(L,P)=sup a_X(L,P,z). If P_M is such that |P_M|=k, we show that A_Q(L,P_M) is a lower bound for t(L), where t(L) is the tunnel number of L. If P is a "boundary partition" of L and g(L,P) denotes the infimum among the sums of the genera of a system of disjoint Seifert surfaces for the L_j's, then we show that A_Q(L,P) is at most 2g(L,P)+2k-|P|-1. We set A_Q(L):=A_Q(L,P_m), where |P_m|=1. By elaborating on a suitable version of a result by Inoue, we show that when L=K is a knot then A_Q(K) is bounded above by A(K), where ...

  4. Classifying serial killers.

    Science.gov (United States)

    Promish, D I; Lester, D

    1999-11-01

    We attempted to match the appearance and demeanor of 27 serial killers to the postmortem 'signatures' found on their victims' bodies. Our results suggest that a link may exist between postmortem signatures and two complementary appearance-demeanor types.

  5. The Windows serial port programming handbook

    CERN Document Server

    Bai, Ying

    2004-01-01

    The fundamentals of serial port communications. Serial port programming in ANSI C and Assembly languages for MS-DOS. Serial ports interface developed in VC++ 6.0. Serial port programming in Visual Basic. Serial port programming in LabVIEW. Serial port programming in MATLAB. Serial port programming in Smalltalk. Serial port programming in Java.

  6. Finite-dimensional (*)-serial algebras

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Let A be a finite-dimensional associative algebra with identity over a field k. In this paper we introduce the concept of (*)-serial algebras which is a generalization of serial algebras. We investigate the properties of (*)-serial algebras, and we obtain suficient and necessary conditions for an associative algebra to be (*)-serial.

  7. Obituary: Donald Alexander Macrae, 1916-2006

    Science.gov (United States)

    Seaquist, E. R.

    2007-12-01

    With the passing of Donald Alexander MacRae on 6 December 2006 at age 90, the astronomy community lost a visionary scientist and a great educator in the field. Don MacRae was born in Halifax, Nova Scotia, on 19 February 1916, to Donald Alexander and Laura Geddes (Barnstead) MacRae. His father was originally a classics scholar and preceptor of Greek and Latin at Princeton, but at the time of Don's birth in 1916 he was Dean of the Dalhousie Law School in Halifax. The family moved to Toronto, Ontario, in 1924 when his father joined the faculty of Osgoode Hall Law School in Toronto as a Professor of Law. After the family moved to Toronto, where he received most of his early education, he obtained his undergraduate degree in Mathematics and Physics in 1937 from the University of Toronto (U of T). He obtained the degree of A.M. in 1940 and of Ph.D. in 1943 from Harvard University under the mentorship of Bart Bok in the field of galactic structure. During his early career he worked briefly at the University of Pennsylvania, Cornell University, and Carbide and Chemical Corporation at Oak Ridge, Tennessee. For Don the latter work was a brief and somewhat uneasy association with the Manhattan Project. In 1946, he obtained a position at Case Institute of Technology (now Case Western Reserve University), where he worked until 1953. In 1953, he accepted a position at the U of T, replacing Ralph Williamson, who had earlier introduced Don to the emerging field of radio astronomy while they both were at Cornell. Don's primary research field was stellar spectroscopy, but his interests were much broader than this, and he possessed an abiding ability to interest students and faculty in new and emerging ideas. In the early 1960s he developed a strong interest in the nature and origin of the lunar surface, and discussed these extensively with colleagues. Many of his ideas on this subject were later confirmed by the lunar exploration program. Don's continuing interest in radio astronomy

  8. Plasma exchange combined with azathioprine in multiple sclerosis using serial gadolinium-enhanced MRI to monitor disease activity: a randomized single-masked cross-over pilot study

    DEFF Research Database (Denmark)

    Sørensen, P.S.; Wanscher, B; Szpirt, W;

    1996-01-01

    the whole trial, and three patients discontinued the trial, two during the run-in period of azathioprine treatment and one at the introduction of PE. The primary efficacy variables were the number of gadolinium-enhancing lesions and the occurrence of new enhancing lesions on serial MRI performed every 3...

  9. Alexander Falconer Sr Seamen's missionary in New Zealand, son Alexander Falconer medical superintendent for mentally ill, grandson Murray Falconer neurosurgeon.

    Science.gov (United States)

    Hawgood, Barbara J

    2016-08-01

    Alexander Falconer Sr (1843-1915) came from Scotland to New Zealand. A practical Christian, he set up places of relaxation for miners, sailors and soldiers; he became the Seamen's Missionary. Son, Dr Alexander Falconer (1874-1955) trained at Otago University Medical School. As medical superintendent for the mentally ill, he urged the early introduction of psychotherapy. His son, Murray Falconer (1910-1977) was the first Nuffield Dominions Clinical Fellow, training in neurosurgery in Oxford. He was the first director of the Guy's-Maudsley Neurosurgical Unit in London and was internationally known for the surgical management of temporal lobe epilepsy in adults and children. PMID:26025843

  10. ECONOMICS OF ALEXANDER THE GREAT (15 vols + 4 cdroms) by Gregory Zorzos

    OpenAIRE

    Gregory Zorzos

    2002-01-01

    Research contains many ancient texts (Ancient Greek, Hebrews, Hieroglyphs, Assyrian, Sumerian, Babylonian, Latin, etc.). 1. (MICRO-MACRO ECONOMICS OF ALEXANDER THE GREAT (5 vols + cdrom). Microeconomics and macroeconomics of Alexander the Great. Economic theories, feasibilities, economic plannings, general description of the campaign's business plan etc. 2. BANKS OF ALEXANDER THE GREAT (2 vols + cdrom) Describes banking system, economists, financiers, investors, accountants, bookkeepers, etc,...

  11. Krahv Alexander von Keyserling / Sirje Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Sirje, 1947-

    2002-01-01

    Alexander Friedrich Michael Lebrecht Arthur Nicolaus James von Keyserlingi (1815-1891) elust ja teaduslikest ekspeditsioonidest Venemaal ning tegevusest Eestis Raikküla mõisnikuna, loodusteadlasena, Eestimaa rüütelkonna peamehena, eesti talupoegade olukorra parandajana, Tartu õpperingkonna kuraatorina, maanõunikuna, tema pereelust ja lastest

  12. Alexander the Great, the dahlia, and the tortoise.

    Science.gov (United States)

    Macmillan, Malcolm

    2004-06-01

    Some of the problems of establishing the cause of the death of Alexander the Great are like the attempts to find causes other than hysteria for Anna O.'s symptoms. The more general problem of using plausibility as a criterion of the truth of such reconstructions are illustrated by the arguments embedded in Tom Stoppard's Arcadia. PMID:15370321

  13. Teaching Nuclear Radiation and the Poisoning of Alexander Litvinenko

    Science.gov (United States)

    David R. Lapp

    2008-01-01

    The recent international story about the death of the former KGB agent Alexander Litvinenko has more than just a few wondering about radiation poisoning and the sinister sounding polonium-210. I was preparing to begin a nuclear radiation unit the Monday after Thanksgiving 2006. As it turned out, Litvinenko died Thanksgiving Day after a short and…

  14. Bemerkungen zu Alexander von Humboldts Russland-Tagebuch

    Directory of Open Access Journals (Sweden)

    Petra Werner

    2008-04-01

    Full Text Available Article in German, Abstracts in English and GermanIn this study the fragment of Alexander von Humboldt’s Siberian personal diary of 1829 is introduced. The evaluation is focussed on Humboldt’s remarks about mineral resources, especially gold and diamonds. Also mentioned are results which Humboldt recorded about geographical, botanical, meteorological, zoological and ethnological questions.

  15. Suicide in serial killers.

    Science.gov (United States)

    Lester, David; White, John

    2010-02-01

    In a sample of 248 killers of two victims in America from 1900 to 2005, obtained from an encyclopedia of serial killers by Newton (2006), those completing suicide did not differ in sex, race, or the motive for the killing from those who were arrested. PMID:20402450

  16. Newcomers to serials

    OpenAIRE

    Everard, Jayne; Stone, Graham

    2002-01-01

    This briefing session will look at the issues facing the librarian who is new to managing serials in the academic library. It will cover the administration and management of both print and e-journals and will consider the particular challenges associated with the hybrid nature of such a role.

  17. Selection and Serial Entrepreneurs

    DEFF Research Database (Denmark)

    Chen, Jing

    2013-01-01

    There is substantial evidence that serial entrepreneurs outperform de novo entrepreneurs. But is this positive association between prior experience and performance the result of learning by doing or of selection on ability? This paper proposes a strategy that combines the fixed-effects model and IV...... when the analysis focuses on founding new startups in sectors closely related to entrepreneurs' previous ventures....

  18. Selection and Serial Entrepreneurs

    DEFF Research Database (Denmark)

    Chen, Jing

    2011-01-01

    Although it has been broadly evidenced that entrepreneurial experience plays a substantial role in the emergence of serial entrepreneurship, the debate is still going on about whether this relationship should be attributed to learning by doing or instead be explained by selection on ability. This...

  19. Suicide in serial killers.

    Science.gov (United States)

    Lester, David; White, John

    2010-02-01

    In a sample of 248 killers of two victims in America from 1900 to 2005, obtained from an encyclopedia of serial killers by Newton (2006), those completing suicide did not differ in sex, race, or the motive for the killing from those who were arrested.

  20. Delaware's first serial killer.

    Science.gov (United States)

    Inguito, G B; Sekula-Perlman, A; Lynch, M J; Callery, R T

    2000-11-01

    The violent murder of Shirley Ellis on November 29, 1987, marked the beginning of the strange and terrible tale of Steven Bryan Pennell's reign as the state of Delaware's first convicted serial killer. Three more bodies followed the first victim, and all had been brutally beaten and sadistically tortured. The body of a fifth woman has never been found. State and county police collaborated with the FBI to identify and hunt down their suspect, forming a task force of over 100 officers and spending about one million dollars. Through their knowledge and experience with other serial killers, the FBI was able to make an amazingly accurate psychological profile of Delaware's serial killer. After months of around-the-clock surveillance, Steven Pennell was arrested on November 29, 1988, one year to the day after the first victim was found. Pennell was found guilty in the deaths of the first two victims on November 29, 1989, and plead no contest to the murder of two others on October 30, 1991. Still maintaining his innocence, he asked for the death penalty so that he could spare his family further agony. Steven Pennell was executed by lethal injection on March 15, 1992.

  1. Delaware's first serial killer.

    Science.gov (United States)

    Inguito, G B; Sekula-Perlman, A; Lynch, M J; Callery, R T

    2000-11-01

    The violent murder of Shirley Ellis on November 29, 1987, marked the beginning of the strange and terrible tale of Steven Bryan Pennell's reign as the state of Delaware's first convicted serial killer. Three more bodies followed the first victim, and all had been brutally beaten and sadistically tortured. The body of a fifth woman has never been found. State and county police collaborated with the FBI to identify and hunt down their suspect, forming a task force of over 100 officers and spending about one million dollars. Through their knowledge and experience with other serial killers, the FBI was able to make an amazingly accurate psychological profile of Delaware's serial killer. After months of around-the-clock surveillance, Steven Pennell was arrested on November 29, 1988, one year to the day after the first victim was found. Pennell was found guilty in the deaths of the first two victims on November 29, 1989, and plead no contest to the murder of two others on October 30, 1991. Still maintaining his innocence, he asked for the death penalty so that he could spare his family further agony. Steven Pennell was executed by lethal injection on March 15, 1992. PMID:11125664

  2. Alexander von Humboldt and the Beginning of the Environmental Movement

    Directory of Open Access Journals (Sweden)

    Engelhard Weigl

    2001-04-01

    Full Text Available Article in English, Abstracts in English and German.In the middle of the 19th century the question whether expanding civilization and industrialization had an effect on climate was discussed intensely worldwide. It was feared that increasing deforestation would lead to continuous decrease in rainfall. This first scientific discussion about climate change as the result of human intervention was strongly influenced by the research Alexander von Humboldt and Jean-Baptiste Boussingault had undertaken when they investigated the falling water levels of Lake Valencia in Venezuela. This essay aims to clarify the question whether Alexander von Humboldt can be counted among the leading figures of modern environmentalism on account of this research as is being claimed by Richard H. Grove in his influential book Green Imperialism. Colonial Expansion, Tropical Island Edens and Origins of Environmentalism, 1600-1860 (1995.

  3. SIGNS AND NARRATIVE DESIGN IN PLUTARCH’S ALEXANDER

    OpenAIRE

    P. Bosman

    2012-01-01

    Plutarch’s Alexander reflects the tendency among earlier Alexandersources to augment the life of the great Macedonian with asupernatural aspect. Plutarch himself selects from, dismisses andfashions this material in accordance with his own standards forresponsible biography, but also with his narrative purposes. Thispaper explores the relationship between signs from the supernaturalsphere (semeia / theia, including dreams, oracles, omens, portents)and Plutarch’s narrative line. In the initial ...

  4. The Old Serbian Alexander Romance and the Greek Phyllada

    Directory of Open Access Journals (Sweden)

    Krzysztof Usakiewicz

    2014-12-01

    Full Text Available The paper includes a short introduction and four excerpts from the Old Serbian Alexander Romance translated into Polish by Maciej Falski. Tekst zawiera krótką prezentację zagadnienia filiacji Opowieści o Aleksandrze w bałkańskiej przestrzeni kulturowej oraz przekład fragmentów tzw. Serbskiej Aleksandreidy na język polski.

  5. Prof. Alexander Strunnikov: Drug Discovery Opportunities Lead Me to China

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    After working for NIH for more than 3.6 years as microorganism genetics expert, in late 203.3-, Alexander Strunnikov joined the CAS Guangzhou Institutes of Biomedicine and Health (GIBH) and embarked on cancer research that had enticed him for quite a few years. As he mentioned, the successful application of the RPFE grant has played a key role, and that he needed only minor lifestyle adjustments to facilitate his work in Guangzhou.

  6. Alexander the Great, Prester John, Strabo of Amasia, and Wonders of the East

    OpenAIRE

    Wang, I-Chun

    2012-01-01

    In her article "Alexander the Great, Prester John, Strabo of Amasia, and Wonders of the East" I-Chun Wang analyses the wonders referred to the realm of Prester John and the imagination of India as exemplified in the pseudo-letter of Alexander the Great. The pseudo letters attributed to Prester John and Alexander demonstrate imagination and identity construction. Throughout history, terra incognita suggested a longing to discover new lands and utopia. Cathay, India, Timbuktu, and El Dorado hav...

  7. Provintsist pärit IT-mõtleja / Alexander Galitsky ; interv. Viktoria Korpan

    Index Scriptorium Estoniae

    Galitsky, Alexander

    2005-01-01

    Venemaa tuntumaid info- ja kõrgtehnoloogiavaldkonna spetsialiste infotehnoloogiast ja selle erinevatest võimalustest, tehnoloogia lahendustest ning avastustest, turvaprobleemidest. Lisa: Alexander Galitsky

  8. Reluctant genius Alexander Graham Bell and the passion for invention

    CERN Document Server

    Gray, Charlotte

    2011-01-01

    The popular image of Alexander Graham Bell is that of an elderly American patriarch, memorable only for his paunch, his Santa Claus beard, and the invention of the telephone. In this magisterial reassessment based on thorough new research, acclaimed biographer Charlotte Gray reveals Bell's wide-ranging passion for invention and delves into the private life that supported his genius. The child of a speech therapist and a deaf mother, and possessed of superbly acute hearing, Bell developed an early interest in sound. His understanding of how sound waves might relate to electrical waves enabled h

  9. HiN : Alexander von Humboldt im Netz

    OpenAIRE

    2010-01-01

    Inhalt: Michael Zeuske: Humboldt en Cuba, 1800/1801 y 1804. Huellas de un enigma Reinaldo Funes Monzote: El cambio socio-ambiental en Cuba a fines del siglo XVIII e inicios del XIX. Impresiones y legado de Alejandro Humboldt. Segundo E. Moreno Yánez, Christiana Borchart de Moreno: Los Andes ecuatoriales: entre la estética y la ciencia. Las catorce láminas relativas al Ecuador en la obra “Vues des Cordillères et Monuments des Peuples Indigènes de l’Amérique” de Alexander von Humboldt Scarlett ...

  10. Theorie und Engagement: Gedenkschrift für Alexander Krafft

    OpenAIRE

    Krafft, Alexander; Ulrich, Günter; Müller-Doohm, Stefan

    2007-01-01

    Dieses Gedenkbuch ist Prof. Dr. Alexander Krafft gewidmet, der am 17. März 2005 nach mehr als 30jähriger Tätigkeit als Soziologe an der Carl von Ossietzky Universität Oldenburg gestorben ist. Der Beitrag von Thomas Blanke ist Ausdruck der Trauer um den Toten - und zeigt zugleich, wie wir im Alltagsleben mit der Erfahrung des Todes fertig werden. Zu den eher theoretisch orientierten Beiträgen zählt die von Krafft/Ulrich verfasste Studie über 'Kultur und Kontingenz'. Den Autoren geht es darum, ...

  11. Bildnisse mit Berg: Goethe und Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Renato Giuseppe Mazzolini

    2004-04-01

    Full Text Available Article in German, translated by Wolfgang Böker, Abstracts in English and GermanBoth Alexander von Humboldt and Johann Wolfgang von Goethe have been portrayed in their later years anachronistically before the background of a mountain that had been of high significance in their earlier biography and carreer. For Goethe this was the Vesuvio, and for Humboldt the Chimborazo. This paper examines the numerous conceptual and formal parallels between the two paintings which make it probable that the Goethe portrait served as a blueprint for the portrait of Humboldt.

  12. Short-term genome stability of serial Clostridium difficile ribotype 027 isolates in an experimental gut model and recurrent human disease.

    Directory of Open Access Journals (Sweden)

    David W Eyre

    Full Text Available BACKGROUND: Clostridium difficile whole genome sequencing has the potential to identify related isolates, even among otherwise indistinguishable strains, but interpretation depends on understanding genomic variation within isolates and individuals. METHODS: Serial isolates from two scenarios were whole genome sequenced. Firstly, 62 isolates from 29 timepoints from three in vitro gut models, inoculated with a NAP1/027 strain. Secondly, 122 isolates from 44 patients (2-8 samples/patient with mostly recurrent/on-going symptomatic NAP-1/027 C. difficile infection. Reference-based mapping was used to identify single nucleotide variants (SNVs. RESULTS: Across three gut model inductions, two with antibiotic treatment, total 137 days, only two new SNVs became established. Pre-existing minority SNVs became dominant in two models. Several SNVs were detected, only present in the minority of colonies at one/two timepoints. The median (inter-quartile range [range] time between patients' first and last samples was 60 (29.5-118.5 [0-561] days. Within-patient C. difficile evolution was 0.45 SNVs/called genome/year (95%CI 0.00-1.28 and within-host diversity was 0.28 SNVs/called genome (0.05-0.53. 26/28 gut model and patient SNVs were non-synonymous, affecting a range of gene targets. CONCLUSIONS: The consistency of whole genome sequencing data from gut model C. difficile isolates, and the high stability of genomic sequences in isolates from patients, supports the use of whole genome sequencing in detailed transmission investigations.

  13. Short-Term Genome Stability of Serial Clostridium difficile Ribotype 027 Isolates in an Experimental Gut Model and Recurrent Human Disease

    Science.gov (United States)

    Eyre, David W.; Walker, A. Sarah; Freeman, Jane; Baines, Simon D.; Fawley, Warren N.; Chilton, Caroline H.; Griffiths, David; Vaughan, Alison; Crook, Derrick W.; Peto, Tim E. A.; Wilcox, Mark H.

    2013-01-01

    Background Clostridium difficile whole genome sequencing has the potential to identify related isolates, even among otherwise indistinguishable strains, but interpretation depends on understanding genomic variation within isolates and individuals. Methods Serial isolates from two scenarios were whole genome sequenced. Firstly, 62 isolates from 29 timepoints from three in vitro gut models, inoculated with a NAP1/027 strain. Secondly, 122 isolates from 44 patients (2–8 samples/patient) with mostly recurrent/on-going symptomatic NAP-1/027 C. difficile infection. Reference-based mapping was used to identify single nucleotide variants (SNVs). Results Across three gut model inductions, two with antibiotic treatment, total 137 days, only two new SNVs became established. Pre-existing minority SNVs became dominant in two models. Several SNVs were detected, only present in the minority of colonies at one/two timepoints. The median (inter-quartile range) [range] time between patients’ first and last samples was 60 (29.5–118.5) [0–561] days. Within-patient C. difficile evolution was 0.45 SNVs/called genome/year (95%CI 0.00–1.28) and within-host diversity was 0.28 SNVs/called genome (0.05–0.53). 26/28 gut model and patient SNVs were non-synonymous, affecting a range of gene targets. Conclusions The consistency of whole genome sequencing data from gut model C. difficile isolates, and the high stability of genomic sequences in isolates from patients, supports the use of whole genome sequencing in detailed transmission investigations. PMID:23691061

  14. Stiffness of serial and quasi-serial manipulators: comparison analysis

    Directory of Open Access Journals (Sweden)

    Klimchik Alexandr

    2016-01-01

    Full Text Available The paper deals with comparison analysis of serial and quasi-serial manipulators. It shows a difference between stiffness behaviours of corresponding industrial robots under external loading, which is caused by machining process. The analysis is based on the estimation of compliance errors induced by cutting forces that are applied to the manipulator end-effector. We demonstrate that the quasi-seral manipulators are preferable for large-dimensional tasks while the quasi-serial ones better suit small size tasks.

  15. [Alexander Borodin--physician, chemist, scientist, teacher and composer].

    Science.gov (United States)

    Vik, T

    1998-12-10

    Concert programmes and CD covers suggest that the Russian composer Alexander Borodin (1833-87) was also a great scientist. In this article we examine this proposition. Borodin was born in St. Petersburg as the illegitimate son of a Russian nobleman. As a boy his talents ranged from music to chemistry and languages. Borodin studied medicine at the Medico-Surgical Academy in St. Petersburg from 1850 to 1855 and defended his doctoral thesis on the similarity between arsenic and phosphoric acid in 1858. He did not, however, feel comfortable in his role as a doctor, and soon started to work as a chemist. In 1864 he was appointed professor of chemistry at the Medico-Surgical Academy. In 1861, Borodin attended the first international congress of chemistry in Karlsruhe, and he was among the founders of the Russian Chemical Society in 1868. He published 42 articles and was a friend of Dmitri Mendeleev, the scientist who described the periodic system. In 1872, Borodin started the first medical courses for women in Russia. It seems warranted to conclude that Alexander Borodin was indeed a great scientist and university teacher, though his immortality was earned by his leisure time activities. PMID:9914755

  16. Kinesthetic Ventures Informed by the Work of F. M. Alexander, Stanislavski, Peirce, and Freud.

    Science.gov (United States)

    Bouchard, Ed; Wright, Ben; Protzel, Michael, Ed.

    This book is about education harvested from self-observation. F. Matthias Alexander (1869-1955) studied the experience of self formation, working with motor habits. His method is used in performing arts training to enhance bodily and vocal expression. Like Alexander, Konstantine Stanislavski (1863-1938) and Sigmund Freud (1856-1939) studied human…

  17. 76 FR 28226 - Ndahendekire Barbara v. African Shipping; Njoroge Muhia; Alco Logistics, Llc; Brenda Alexander...

    Science.gov (United States)

    2011-05-16

    ... Ndahendekire Barbara v. African Shipping; Njoroge Muhia; Alco Logistics, Llc; Brenda Alexander; and AIR 7 Seas... ``Complainant,'' against African Shipping; Njoroge Muhia, ALCO Logistics, LLC; Brenda Alexander; and Air 7 Seas Transport Logistics, Inc.; hereinafter ``Respondents''. Complainant asserts that she is acting agent...

  18. Political Essay on the Island of Cuba: A Critical Edition - by Von Humboldt, Alexander [Ressenya

    OpenAIRE

    Sánchez Cobos, Amparo

    2013-01-01

    Review of the book: Political Essay on the Island of Cuba: A Critical Edition / Alexander von Humboldt; edited by Vera M. Kutzinski and Ottmar Ette.- Chicago: University of Chicago Press, 2011. xxvi+519 p. - ISBN 9780226465678. - (Alexander von Humboldt in English)

  19. Whole rice bran for beef heifers raised on alexander grass pasture

    Directory of Open Access Journals (Sweden)

    P. R. Salvador

    2016-09-01

    Full Text Available The objective of this study was to evaluate the development of beef heifers exclusively fed alexander grass (Urochloa plantaginea (Link Hitch or alexander grass and whole rice meal as supplement offered from Monday to Friday. The experimental design was completely randomized, with repeated measures over time, and consisted of two treatments and three replications of area. Heifers receiving whole rice meal exhibited higher average daily gain after day 42 of pasture use and a 21% higher body weight at the end of the grazing period. The stocking rate, weight gain per area, hip height, weight-height ratio, and body condition score were similar for heifers exclusively fed alexander grass and alexander grass plus rice bran. Beef heifers raised exclusively on alexander grass from 15 to 18 months of age reached adequate body development, reproductive tract score (4.22 points and pelvic area (206.3 cm² to be bred at 18-20 months of age.

  20. ALEXANDER OF APHRODISIAS’ THE VIEWS BELONGING TO THE METAPHYSICS IN THE CONTEXT OF ARISTOTLE AND ISLAMIC PHILOSOPHERS

    OpenAIRE

    Sarıtaş, Kamil

    2012-01-01

    Alexander of Aphrodisias is a philosopher and commentator who is a member of Aristotelian school. In the history of philosophy Alexander who is first commentator taking up in detail of Peripatetism was admitted greatly influenced Islamic philosophers as well. In this article it was intended to be adressing the views of metaphysics of Alexander of Aphrodisias. His thoughts related Metaphysics such being, God, mind and immortality were included. However, by being compared Alexander's ideas ...

  1. Auditory distraction and serial memory

    OpenAIRE

    Jones, D M; Hughes, Rob; Macken, W.J.

    2010-01-01

    One mental activity that is very vulnerable to auditory distraction is serial recall. This review of the contemporary findings relating to serial recall charts the key determinants of distraction. It is evident that there is one form of distraction that is a joint product of the cognitive characteristics of the task and of the obligatory cognitive processing of the sound. For sequences of sound, distraction appears to be an ineluctable product of similarity-of-process, specifically, the seria...

  2. Alexander the Great's tombolos at Tyre and Alexandria, eastern Mediterranean

    Science.gov (United States)

    Marriner, N.; Goiran, J. P.; Morhange, C.

    2008-08-01

    Tyre and Alexandria's coastlines are today characterised by wave-dominated tombolos, peculiar sand isthmuses that link former islands to the adjacent continent. Paradoxically, despite a long history of inquiry into spit and barrier formation, understanding of the dynamics and sedimentary history of tombolos over the Holocene timescale is poor. At Tyre and Alexandria we demonstrate that these rare coastal features are the heritage of a long history of natural morphodynamic forcing and human impacts. In 332 BC, following a protracted seven-month siege of the city, Alexander the Great's engineers cleverly exploited a shallow sublittoral sand bank to seize the island fortress; Tyre's causeway served as a prototype for Alexandria's Heptastadium built a few months later. We report stratigraphic and geomorphological data from the two sand spits, proposing a chronostratigraphic model of tombolo evolution.

  3. Teaching Nuclear Radiation and the Poisoning of Alexander Litvinenko

    Science.gov (United States)

    Lapp, David R.

    2008-03-01

    The recent international story about the death of the former KGB agent Alexander Litvinenko has more than just a few wondering about radiation poisoning and the sinister sounding polonium-210. I was preparing to begin a nuclear radiation unit the Monday after Thanksgiving 2006. As it turned out, Litvinenko died Thanksgiving Day after a short and terrible three-week illness. Having the story continue to unfold throughout the next two weeks of the new unit provided a daily opportunity for students to see the relevance of what we were doing in class. My students were able to have meaningful and informed conversations with their peers and parents over an important international event. They even began to feel a bit like authorities themselves when listening to experts respond to media questions about polonium-210 and nuclear radiation in general. This paper discusses some of the ways that the story of Litvinenko was used while presenting the topic of nuclear radiation.

  4. Alexander v. Sandoval:A Setback for Civil Rights

    Directory of Open Access Journals (Sweden)

    Kevin G. Welner

    2001-06-01

    Full Text Available This article confronts the serious implications of a recent U.S. Supreme Court decision, Alexander v. Sandoval, which eliminated an important legal avenue for civil rights plaintiffs. For over 35 years, individuals have been allowed to bring lawsuits directly challenging violations of rights set forth in the federal regulations implementing Title VI of the 1964 Civil Rights Act. Because these actions could be grounded in proof of disparate impact, rather than discriminatory intent, they allowed for some claims that could not go forward under other legal authorities, such as the Fourteenth Amendment. While the author concludes by identifying key remaining options, he highlights the real damage done by this decision.

  5. Serial Input Output

    Energy Technology Data Exchange (ETDEWEB)

    Waite, Anthony; /SLAC

    2011-09-07

    Serial Input/Output (SIO) is designed to be a long term storage format of a sophistication somewhere between simple ASCII files and the techniques provided by inter alia Objectivity and Root. The former tend to be low density, information lossy (floating point numbers lose precision) and inflexible. The latter require abstract descriptions of the data with all that that implies in terms of extra complexity. The basic building blocks of SIO are streams, records and blocks. Streams provide the connections between the program and files. The user can define an arbitrary list of streams as required. A given stream must be opened for either reading or writing. SIO does not support read/write streams. If a stream is closed during the execution of a program, it can be reopened in either read or write mode to the same or a different file. Records represent a coherent grouping of data. Records consist of a collection of blocks (see next paragraph). The user can define a variety of records (headers, events, error logs, etc.) and request that any of them be written to any stream. When SIO reads a file, it first decodes the record name and if that record has been defined and unpacking has been requested for it, SIO proceeds to unpack the blocks. Blocks are user provided objects which do the real work of reading/writing the data. The user is responsible for writing the code for these blocks and for identifying these blocks to SIO at run time. To write a collection of blocks, the user must first connect them to a record. The record can then be written to a stream as described above. Note that the same block can be connected to many different records. When SIO reads a record, it scans through the blocks written and calls the corresponding block object (if it has been defined) to decode it. Undefined blocks are skipped. Each of these categories (streams, records and blocks) have some characteristics in common. Every stream, record and block has a name with the condition that each

  6. [Serial episodes of gastric and cecal perforation in a patient with Behcet's disease involving the whole gastrointestinal tract: a case report].

    Science.gov (United States)

    Shin, Dong Yeob; Cheon, Jae Hee; Park, Jae Jun; Kim, Hoguen; Kim, Tae Il; Lee, Yong Chan; Kim, Nam Kyu; Kim, Won Ho

    2009-02-01

    Behcet's disease (BD) has been recognized as multi-systemic chronic vasculitic disorder of recurrent inflammation, characterized by the involvement of multiple organs and resulting in orogenital ulcers, uveitis, and skin lesions. Involvement of the central nervous system, vessels, and intestines in BD often leads to a poor prognosis. Digestive manifestations in BD have been reported in up to 1-60% of cases, although the rate varies in different countries. The most frequent extra-oral sites of gastrointestinal involvement are the ileocecal region and the colon. Gastric or esophageal involvement is reported to be very rare. Moreover, there have been no reports on the simultaneous involvement of the esophagus, stomach, ileum, and colon. Here, we present a 55-year-old Korean man with intestinal BD and multiple ileal and colonic ulcerations complicated by perforation, gastric ulcer with bleeding followed by perforation, and esophageal ulcers with bleeding.

  7. Siim Nestor soovitab : Ben Frost ja Alexander Robotnik Eclectical / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2007-01-01

    Austraalia muusik ja helilooja Ben Frost projektiga "6 guitars" esinemas festivali Eclectica raames 6. sept. Tartu klubis Rock ja Roll ja itaalia diskor Alexander Robotnik 7. sept. klubis Trehv, esinejatest

  8. The Berlin tradition in Chicago: Franz Alexander and the Chicago Institute for Psychoanalysis.

    Science.gov (United States)

    Schmidt, Erika S

    2010-01-01

    Freud considered Franz Alexander, the first graduate of the Berlin Psychoanalytic Institute and an assistant in the Berlin Polyclinic, to be "one of our strongest hopes for the future." Alexander went on to become the first director of the Chicago Institute for Psychoanalysis in 1932 and modeled some of the Chicago Institute's mission on his Berlin experiences. He was also a researcher in psychosomatic medicine, a prolific writer about psychoanalysis and prominent in psychoanalytic organizations. As he proposed modifications in psychoanalytic technique, he became a controversial figure, especially in the elaboration of his ideas about brief therapy and the corrective emotional experience. This paper puts Alexander's achievements in historical context, draws connections between the Berlin and Chicago Institutes and suggests that, despite his quarrels with traditional psychoanalysis, Alexander's legacy may be in his attitude towards psychoanalysis, characterized by a commitment to scientific study, a willingness to experiment, and a conviction about the role of psychoanalysis within the larger culture.

  9. Jules Vernes literarische Thematisierung der Kanarischen Inseln als Hommage an Alexander von Humboldt

    OpenAIRE

    Georg Schifko

    2010-01-01

    Article in German. AbstractJules Verne’s very short literary treatment of the Canary Islands underlines his talent as a science novelist. It also reveals him to be a great admirer of Alexander von Humboldt.

  10. Use of serial assessment of disease severity and liver biopsy for indication for liver transplantation in pediatric Epstein-Barr virus-induced fulminant hepatic failure.

    Science.gov (United States)

    Nakazawa, Atsuko; Nakano, Natsuko; Fukuda, Akinari; Sakamoto, Seisuke; Imadome, Ken-Ichi; Kudo, Toyoichiro; Matsuoka, Kentaro; Kasahara, Mureo

    2015-03-01

    The decision to perform liver transplantation (LT) in patients with Epstein-Barr virus (EBV)-induced fulminant hepatic failure (FHF) relies on a precise assessment of laboratory and pathological findings. In this study, we analyzed clinical and laboratory data as well as the pathological features of the liver in order to evaluate the pathogenesis and the need for LT in 5 patients with EBV-induced FHF. According to the King's College criteria, the Acute Liver Failure Early Dynamic (ALFED) model, and the Japanese criteria (from the Acute Liver Failure Study Group of Japan), only 1 patient was considered to be a candidate for LT. However, explanted liver tissues in 3 cases exhibited massive hepatocellular necrosis together with diffuse CD8-positive T cell infiltration in both the portal area and the sinusoid. EBV was detected in the liver, plasma, and peripheral blood mononuclear cells (PBMNCs). In 2 cases indicated to be at moderate risk by the ALFED model, liver biopsy showed CD8-positive and EBV-encoded RNA signal-positive lymphocytic infiltration predominantly in the portal area, but massive hepatocellular necrosis was not observed. These patients were treated with immunosuppressants and etoposide under the diagnosis of EBV-induced hemophagocytic lymphohistiocytosis or systemic EBV-positive T cell lymphoproliferative disease of childhood. EBV DNA was detected at a high level in PBMNCs, although it was negative in plasma. On the basis of the pathological analysis of the explanted liver tissues, LT was proposed for the restoration of liver function and the removal of the EBV-infected lymphocytes concentrated in the liver. Detecting EBV DNA by a quantitative polymerase chain reaction in plasma and PBMNCs was informative. An accurate evaluation of the underlying pathogenesis is essential for developing a treatment strategy in patients with EBV-induced FHF.

  11. La pasión de Alexander Crichton

    Directory of Open Access Journals (Sweden)

    Matusevich, Daniel

    2015-12-01

    Full Text Available Alexander Crichton was born in Edinburgh in 1763; he graduated from Leyden University and travelled through Berlín, Paris, Stuttgart, Prague and Gotinga to perfect his knowledge in medicine while he establish a deep connection between the social media and the culture of those places. On 1798 he published An inquiry into the nature and origin of Mental Derangement, the only book he wrote dedicated to madness. In this paper we review some questions referred to the general method that the author applies, his contributions to the semiotics of the mind and to the analysis of the process of aging and the function of the attention; we also take a look to his conception of the world of passions and of madness, who influenced Philippe Pinel and Dominique Esquirol and also constitute a cornerstone in the birth of psychiatry.Alexander Crichton, nació en Edimburgo en 1763, se graduó en la Universidad de Leyden y completó su formación médica en Berlín, Paris, Stuttgart, Praga y Gotinga, vinculándose estrechamente con el ambiente social y cultural de esos prestigiosos centros europeos. En el año 1798 publicó An Inquiry into the nature and origin of Mental Derangement (Investigación sobre la naturaleza y el origen del trastorno mental, única obra de su autoría dedicada a la locura. En este artículo se analizan algunas cuestiones referidas al método general que aplica el autor para la concepción de su obra, sus contribuciones a la semiología de la mente, al análisis del proceso de envejecimiento y a la función de la atención, para detenernos, finalmente, en su conceptuación del mundo de las pasiones y de la locura que fueron retomadas por otros autores como Philippe Pinel y Dominique Esquirol, y que constituyeron un antecedente fundamental en el nacimiento de la psiquiatría.

  12. Jules Vernes literarische Thematisierung der Kanarischen Inseln als Hommage an Alexander v. Humboldt

    OpenAIRE

    Schifko (Wien), Georg

    2011-01-01

    Der vorliegende Artikel zeigt auf, dass Jules Vernes einzige und sehr kurze belletristische Thematisierung der Kanarischen Inseln ihn als Vertreter des Wissenschaftsromans, und ebenso als großen Bewunderer des Gelehrten Alexander v. Humboldt ausweisen. Jules Verne’s very short literary treatment of the Canary Islands underlines his talent as a science novelist. It also reveals him to be a great admirer of Alexander von Humboldt. Este artículo, demuestra que la única y muy breve referenc...

  13. A Review of Passionate Patron: The Life of Alexander Hardcastle and the Greek Temples of Agrigento

    OpenAIRE

    Antonino Crisa

    2014-01-01

    Richardson’s 143-page book provides an interesting account on the life of Alexander Hardcastle (London, 1872 – Agrigento, 1933), a rich English patron and archaeologist, who operated in Sicily during the early twentieth century. Son of Hernt and Marie Sophie Hardcastle Herschel, Alexander took his military service in the Royal Navy, gaining a thorough technical knowledge, which he successfully used in Sicily. After he obtained a passport in December 1920, Hardcastle moved to Girgenti (now Agr...

  14. Holocene morphogenesis of Alexander the Great's isthmus at Tyre in Lebanon

    OpenAIRE

    Marriner, Nick; Morhange, Christophe; Meulé, Samuel

    2007-01-01

    In 332 B.C., Alexander the Great constructed an ≈1,000-m-long causeway to seize the offshore island of Tyre. The logistics behind this engineering feat have long troubled archaeologists. Using the Holocene sedimentary record, we demonstrate that Alexander's engineers cleverly exploited a shallow proto-tombolo, or sublittoral sand spit, to breach the offshore city's defensive impregnability. We elucidate a three-phase geomorphological model for the spit's evolution. Settled since the Bronze Ag...

  15. Reflection in Russian public opinion accession to the throne of Emperor Alexander II

    OpenAIRE

    Maxim N. Krot; Oksana O. Zavyalova

    2016-01-01

    The article deals with the perception of Russian society coming to the throne of Emperor Alexander II in 1855. The author analyzes the internal and external situation in Russia in this period, identifying the most significant factors that influenced the public's attitude to the new monarch, and the expectations that were associated with his coming to power. The article draws parallels between the initial period of the reign of the two liberal Russian monarchs of the XIX century – Alexander I ...

  16. IN MEMORIAM: In Memoriam: Alexander A Golovin and Alexei M Oparin In Memoriam: Alexander A Golovin and Alexei M Oparin

    Science.gov (United States)

    2008-10-01

    In Memoriam of Alexander A Golovin (1962-2008) Alexander (Sasha) Golovin passed away on 10 September 2008. Sasha's scientific heritage includes seminal works in different fields of physics, from Marangoni convection to self-assembly of quantum dots, and from combustion fronts to anomalous diffusion in flows and on a crystal surface. A graduate of the Moscow Institute for Physics and Technology, he had very broad scientific interests and a unique ability to identify and solve new, intellectually challenging and technologically important problems. One of the basic fields of Sasha's research was the fluid dynamics in systems with interfaces. His favorite subject was the motion of droplets, bubbles and particles in the presence of heat and mass transfer. Sasha's early works contained the discovery of the spontaneous motion of droplets due to the Marangoni effect and the investigation of the interaction between solid particles, bubbles and droplets caused by the Marangoni effect, which is a crucial factor that determines the effect of heat/mass transfer on the rate of coalescence. In both cases, Sasha's work was the first in a long sequence of papers written by different authors. Later, Sasha returned to that field when studying such fascinating subjects as levitation of droplets above the surface of an evaporating liquid and encapsulation of particles and bubbles by an advancing solidification front. The subject of interfacial hydrodynamics overlaps with another basic field of Sasha's research, the theory of pattern formation. The contribution of Sasha's work to the modern understanding of the variety of pattern formation phenomena is significant. It includes the analysis of the interaction between long-wave and short-wave instability modes in Marangoni convection, investigation of the large-scale Marangoni convection that led to the prediction of different patterns including quasipatterns, and the description of various non-potential effects in Marangoni convection

  17. Alexander Forbes, Walter Cannon, and science-based literature.

    Science.gov (United States)

    Garson, Justin

    2013-01-01

    The Harvard physiologists Alexander Forbes (1882-1965) and Walter Bradford Cannon (1871-1945) had an enormous impact on the physiology and neuroscience of the twentieth century. In addition to their voluminous scientific output, they also used literature to reflect on the nature of science itself and its social significance. Forbes wrote a novel, The Radio Gunner, a literary memoir, Quest for a Northern Air Route, and several short stories. Cannon, in addition to several books of popular science, wrote a literary memoir in the last year of his life, The Way of an Investigator. The following will provide a brief overview of the life and work of Forbes and Cannon. It will then discuss the way that Forbes used literature to express his views about the changing role of communications technology in the military, and his evolving view of the nervous system itself as a kind of information-processing device. It will go on to discuss the way that Cannon used literature to articulate the horrors he witnessed on the battlefield, as well as to contribute to the philosophy of science, and in particular, to the logic of scientific discovery. Finally, it will consider the historical and philosophical value of deeper investigation of the literary productions of scientists. PMID:24290268

  18. Alexander von Humboldt und die transnationale Wissenschaftskommunikation im 19. Jahrhundert

    Directory of Open Access Journals (Sweden)

    Ulrich Päßler

    2008-10-01

    Full Text Available Article in german, abstracts in english and frenchAlexander von Humboldt has been labelled a “scientific cosmopolitan”. Through his vast correspondence and a network of personal contacts, he upheld a form of scientific exchange that was characteristic of the eighteenth-century “republic of letters”.This article examines how Humboldt adapted this cosmopolitan tradition of communication to a nineteenth century scientific culture that was largely institutionalized and was becoming increasingly nationalized. Humboldt quite successfully fostered scientific exchange between Berlin and Paris after 1830 and, on various occasions between the 1830s and 1850s, readily advocated international large-scale projects. These examples demonstrate that Humboldt observed the development of nationally defined scientific cultures and the opening of the sciences towards the public realm. Moreover, they indicate how he was able to make use of these developments as he promoted the sciences in Prussia. In scientific controversies within the Parisian scientific community, Humboldt was involuntarily assigned the role of a “neutral” foreign arbitrator. Thus, the development of nineteenth century sciences also jeopardized Humboldt’s unique position as an independent “homme des lettres”.

  19. Serial crystallography for the masses?

    OpenAIRE

    Wright, Jonathan P.

    2015-01-01

    Serial crystallography should be possible with a much wider range of radiation sources as Ayyer et al. [ IUCrJ (2015), 2, 29–34] show that crystallographic intensities can be recovered from randomly oriented frames which are too sparse for indexing.

  20. 24 CFR 3280.6 - Serial number.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Serial number. 3280.6 Section 3280... DEVELOPMENT MANUFACTURED HOME CONSTRUCTION AND SAFETY STANDARDS General § 3280.6 Serial number. (a) A manufactured home serial number which will identify the manufacturer and the state in which the...

  1. The life and death of Alexander Bogdanov, physician.

    Science.gov (United States)

    Huestis, D W

    1996-08-01

    It was early in April in 1928 when the word went out in Moscow that Alexander Bogdanov had died. He was a controversial figure, an old Bolshevik who had left that party long before the 1917 revolution and never returned. All the same, he had had Lenin's respect as a scientist (as long as he stayed out of politics). More recently, he also had the support of the new party strong man, Stalin. Bogdanov opposed the growing despotism of the "dictatorship of the proletariat", under which slogan Communist autocracy was being developed. But he was respected as a tireless propagandist for the socialist cause, an enthusiastic teacher of the proletariat, and a writer of arcane science and philosophy. Bogdanov was held in such respect that Communist bigwigs spoke glowingly at the funeral, praising his intellect, courage, and dedication to science and humanity. They did not fail to point out that he had split with his one-time friend, Lenin, and had succumbed to ideological "errors". Indeed, he had powerful enemies in the early Soviet state. Bogdanov was a physician, economist, philosopher, natural scientist, writer of utopian science fiction, poet, teacher, politician (unsuccesful), lifelong revolutionary, forerunner of what we now call cybernetics and organizational science, and founder of the world's first institution devoted entirely to the field of blood transfusion. You could call him a Renaissance man. Although he clearly fitted the category of the late-nineteenth-century Russian intellectual revolutionary, Bogdanov differed from most of them in being no dilettante. More than just a theorist, he was an active scientist and physician. As a teacher, he firmly believed that education and indoctrination could alter people's ways of thinking and behaving, and that humanity could be perfected under socialism. Like many revolutionaries, Bogdanov tried to keep ahead of the Tsar's police by using a variety of pseudonyms, among them Riadavoy, Werner, Maximov, and Bogdanov. After

  2. Serial killer: il database mondiale

    Directory of Open Access Journals (Sweden)

    Gaetano parente

    2016-07-01

    Full Text Available The complex and multisided study of serial killers is partly made difficult by the current level of progress that has led these deviant people to evolve in relation to the aspects of shrewdness (concerning the staging and mobility. Despite the important work of some scholars who proposed important theories, all this shows that, concerning serial murders, it is still particularly frequent not to pay attention to links among homicides committed by the same person but in different parts of the world. It is therefore crucial to develop a worldwide database that allows all police forces to access information collected on crime scenes of murders which are particularly absurd and committed without any apparent reason. It will then be up to the profiler, through ad hoc and technologically advanced tools, to collect this information on the crime scene that would be made available to all police forces thanks to the worldwide database.

  3. Nanoflow electrospinning serial femtosecond crystallography

    International Nuclear Information System (INIS)

    A low flow rate liquid microjet method for delivery of hydrated protein crystals to X-ray lasers is presented. Linac Coherent Light Source data demonstrates serial femtosecond protein crystallography with micrograms, a reduction of sample consumption by orders of magnitude. An electrospun liquid microjet has been developed that delivers protein microcrystal suspensions at flow rates of 0.14–3.1 µl min−1 to perform serial femtosecond crystallography (SFX) studies with X-ray lasers. Thermolysin microcrystals flowed at 0.17 µl min−1 and diffracted to beyond 4 Å resolution, producing 14 000 indexable diffraction patterns, or four per second, from 140 µg of protein. Nanoflow electrospinning extends SFX to biological samples that necessitate minimal sample consumption

  4. The sexually sadistic serial killer.

    Science.gov (United States)

    Warren, J I; Hazelwood, R R; Dietz, P E

    1996-11-01

    This article explores characteristics and crime scene behavior of 20 sexually sadistic serial murderers. The pairing of character pathology with paraphilic arousal to the control and degradation of others is examined as it manifests itself in their murders. Commonalities across murders and across murderers are highlighted, i.e., the execution of murders that are well-planned, the use of preselected locations, captivity, a variety of painful sexual acts, sexual bondage, intentional torture, and death by means of strangulation and stabbing.

  5. Nanoflow electrospinning serial femtosecond crystallography.

    Science.gov (United States)

    Sierra, Raymond G; Laksmono, Hartawan; Kern, Jan; Tran, Rosalie; Hattne, Johan; Alonso-Mori, Roberto; Lassalle-Kaiser, Benedikt; Glöckner, Carina; Hellmich, Julia; Schafer, Donald W; Echols, Nathaniel; Gildea, Richard J; Grosse-Kunstleve, Ralf W; Sellberg, Jonas; McQueen, Trevor A; Fry, Alan R; Messerschmidt, Marc M; Miahnahri, Alan; Seibert, M Marvin; Hampton, Christina Y; Starodub, Dmitri; Loh, N Duane; Sokaras, Dimosthenis; Weng, Tsu-Chien; Zwart, Petrus H; Glatzel, Pieter; Milathianaki, Despina; White, William E; Adams, Paul D; Williams, Garth J; Boutet, Sébastien; Zouni, Athina; Messinger, Johannes; Sauter, Nicholas K; Bergmann, Uwe; Yano, Junko; Yachandra, Vittal K; Bogan, Michael J

    2012-11-01

    An electrospun liquid microjet has been developed that delivers protein microcrystal suspensions at flow rates of 0.14-3.1 µl min(-1) to perform serial femtosecond crystallography (SFX) studies with X-ray lasers. Thermolysin microcrystals flowed at 0.17 µl min(-1) and diffracted to beyond 4 Å resolution, producing 14,000 indexable diffraction patterns, or four per second, from 140 µg of protein. Nanoflow electrospinning extends SFX to biological samples that necessitate minimal sample consumption. PMID:23090408

  6. Notorious Cases of Serial Killers

    Directory of Open Access Journals (Sweden)

    Iosub Elena-Cătălina

    2014-05-01

    Full Text Available The reconstruction of a death scene provides an overall picture of the crime and will indicate the murder as an event or one of a series of events and also the criminal. But when the criminal is declared a serial killer, many questions are raised up. How could a person kill some else without a reason or why people react in such a disorganized way and become so brutal or what made them act like that and so many questions with also so many answers. This project explains the psychology of a murderer, his own way of thinking and acting by presuming that we may accurately discover what is in their minds when they kill. It is about a very complex issue regarding murder investigations, biological factors and psychological profile of a serial killer. Dealing with this problem we will at last reach to the question that could solve finally the puzzle: ―Are serial murderers distorted reflections of society's own values?

  7. Serial murder by healthcare professionals.

    Science.gov (United States)

    Yorker, Beatrice Crofts; Kizer, Kenneth W; Lampe, Paula; Forrest, A R W; Lannan, Jacquetta M; Russell, Donna A

    2008-01-01

    The prosecution of Charles Cullen, a nurse who killed at least 40 patients over a 16-year period, highlights the need to better understand the phenomenon of serial murder by healthcare professionals. The authors conducted a LexisNexis search which yielded 90 criminal prosecutions of healthcare providers that met inclusion criteria for serial murder of patients. In addition we reviewed epidemiologic studies, toxicology evidence, and court transcripts, to provide data on healthcare professionals who have been prosecuted between 1970 and 2006. Fifty-four of the 90 have been convicted; 45 for serial murder, four for attempted murder, and five pled guilty to lesser charges. Twenty-four more have been indicted and are either awaiting trial or the outcome has not been published. The other 12 prosecutions had a variety of legal outcomes. Injection was the main method used by healthcare killers followed by suffocation, poisoning, and tampering with equipment. Prosecutions were reported from 20 countries with 40% taking place in the United States. Nursing personnel comprised 86% of the healthcare providers prosecuted; physicians 12%, and 2% were allied health professionals. The number of patient deaths that resulted in a murder conviction is 317 and the number of suspicious patient deaths attributed to the 54 convicted caregivers is 2113. These numbers are disturbing and demand that systemic changes in tracking adverse patient incidents associated with presence of a specific healthcare provider be implemented. Hiring practices must shift away from preventing wrongful discharge or denial of employment lawsuits to protecting patients from employees who kill.

  8. 非手术序列化治疗单侧梅尼埃病48例%Non-surgical serialization treatment of unilateral Meniere disease in 48 cases

    Institute of Scientific and Technical Information of China (English)

    张运波; 习国平; 靳红芳; 王彩君

    2016-01-01

    Objective To explore the efficacy of treating Meniere disease by non-operative serialization through various listening stages.Methods Serialized treatment was conducted in 48 patients with unilateral Meniere disease according to the listening stages.In period Ⅰ,patients received regular diet control,blood vessel expansion,nerve nutrition and vitamin medication.In period Ⅱ,on the basis of conventional treatment,patients were injected with odium succinate 40 mg,once in 3 days for 3 times.If it was not effective,tympanostomy tube and tympanic cavity inflation were ad-ministered.In period Ⅲ,on the basis of regular treatment,patients underwent tympanic cavity perfusion after tympa-nostomy tube and injection of prednisolone sodium of 40 mg,once in 3 days for 3 times,and received inflation treat-ment in middle ear drum balloon.In period Ⅳ,on the basis of conventional treatment,patients received gentamicin 40 000 U +0.5%,sodium bicarbonate 0.5 mL and tympanic cavity injection once a week.The frequency of injection was commonly 2-3 times a week,determined by circumgyration,hearing changes and situations of tinnitus.For patients who had low vestibular apparatus function,rehabilitation training of vestibular function was provided.Patients’vertigo, hearing,activity ability and tinnitus changes were followed up for 18-24 months.Results Vertigo was fully controlled in 12 cases,basically controlled in 33 cases,partially controlled in 3 cases,and the clinical effective rate was 93%. The hearing ability was improved to A level in 12 cases (>30 db or the frequency <20 db),to B level in 6 cases (15-30 db),to C level in 29 cases (0-14 db),and to Dlevel in 1 case (improvement <0 db).The mobility was fully con-trolled in 16 cases (A level),basically controlled in 32 cases (B level),and the effective rate was 100%.The score of Tinnitus Handicap Inventory after treatment was significantly decreased (P <0.05 ).Conclusion Treatment of Meniere disease vertigo by non

  9. Alexander Numan (1780-1852) en de veredeling van de Nederlandse schapenrassen

    OpenAIRE

    Jesper Oldenburger; Bert Theunissen

    2015-01-01

    Alexander Numan and the improvement of the Dutch sheep breedsAlexander Numan’s life and work provide a splendid illustration of the early nineteenth-century Dutch scientist’s view of the role of science and scientists in society. As a professor at the Utrecht veterinary school he spent a substantial part of his time on a practical endeavour: the improvement of the wool quality of the Dutch sheep breeds. He did not confine his activities to the scientific aspects only, but aimed to obtain the ...

  10. De luchtvaart van Alexander de Grote in de verbeelding der Middeleeuwen.

    OpenAIRE

    Schmidt, Victor Michael

    1988-01-01

    The story of Alexander the Great's Aerial Flight holds a special position among the manifold legendary traditions around the famous world conqueror that were known during the Middle Ages, since no other legend of his miraculous life was represented so often in art as this one. According to the legend Alexander had travelled through the sky in a vehicle drawn by griffins, which he had lured upward by holding meat in front of them. A review of the existing literature on the subject, notably the...

  11. Notorious Cases of Serial Killers

    OpenAIRE

    Iosub Elena-Cătălina

    2014-01-01

    The reconstruction of a death scene provides an overall picture of the crime and will indicate the murder as an event or one of a series of events and also the criminal. But when the criminal is declared a serial killer, many questions are raised up. How could a person kill some else without a reason or why people react in such a disorganized way and become so brutal or what made them act like that and so many questions with also so many answers. This project explains the psycholo...

  12. The sexually sadistic serial killer.

    Science.gov (United States)

    Warren, J I; Hazelwood, R R; Dietz, P E

    1996-11-01

    This article explores characteristics and crime scene behavior of 20 sexually sadistic serial murderers. The pairing of character pathology with paraphilic arousal to the control and degradation of others is examined as it manifests itself in their murders. Commonalities across murders and across murderers are highlighted, i.e., the execution of murders that are well-planned, the use of preselected locations, captivity, a variety of painful sexual acts, sexual bondage, intentional torture, and death by means of strangulation and stabbing. PMID:8914287

  13. Tartu ülikooli Vene ajaloo professor Alexander Brückner (1834-1896) / Tiit Rosenberg

    Index Scriptorium Estoniae

    Rosenberg, Tiit, 1946-

    2004-01-01

    Alexander Brückneri elust, vaadetest, loomingust ja perekonnast. Alexander Brücknerist kui Õpetatud Eesti Seltsi liikmest. Tartu Ülikooli vene ajaloo õppejõududest. Lühidalt Tartust pärit vene ajaloo uurijast Ernst Adolf Herrmannist

  14. Reconciling rising serials costs, the serials budget, and reference needs in a medical library serials retrenchment program: a methodology.

    Science.gov (United States)

    Spang, L

    1995-01-01

    Devising a coherent serials retrenchment plan while maintaining quality reference service is a dilemma faced by increasing numbers of medical librarians. In 1991, the staff of the Shiffman Medical Library, Wayne State University, began to address increasing serials budget reductions that by 1994 amounted to a projected 20% maximum cut. The resulting retrenchment plan combined an ongoing serials use study, faculty and librarian reviews of cancellation lists, and systematic refinements in interlibrary cooperation and document delivery service. The Shiffman plan provides a constructive framework that can be adapted to other medical libraries facing immediate, major serials retrenchment.

  15. Coalgèbres d'Alexander-Whitney: un modèle algébrique pour les espaces topologiques

    OpenAIRE

    Naïto, Théophile

    2009-01-01

    The goal of this work is to study Alexander-Whitney coalgebras (first defined in [HPST06]) from a topological point of view. An Alexander-Whitney coalgebra is a coassociative chain coalgebra over Z with an extra algebraic structure : the comultiplication must respect the coalgebra structure up to an infinite sequence of homotopies (this sequence is part of the data of the Alexander-Whitney coalgebra structure). Alexander-Whitney coalgebras are interesting for topologists because the normalize...

  16. Stubb : EL saavutas Gruusia kriisi ajal palju / Alexander Stubb ; interv. Liisi Poll

    Index Scriptorium Estoniae

    Stubb, Alexander, 1968-

    2008-01-01

    Intervjuu Soome välisministri Alexander Stubbiga, kes vastab küsimustele, mis puudutavad Euroopa Liidu positsiooni seoses Venemaa agressiooniga Gruusias ja Soome seisukohti seoses NATOga. Euroliidu reaktsioon Venemaa agressioonile Gruusias oli poliitiliselt tugev ja majanduslikult nõrk, arvab ta

  17. Vorstenschool. Vier geschiedenisschrijvers over Alexander en hun visie op het keizerschap

    NARCIS (Netherlands)

    Mulder-Bakker, Antje Beitske

    1983-01-01

    Alexander the Great has been renowned both in the middle ages and at other times as one of the most celebrated heroes. Stories of his deeds have been handed down in almost every language and civilization. He was known everywhere, loved by everyone. He was world famous. This very fact diminishes his

  18. Russia's Literary Genius Alexander Pushkin: The Great-Grandson of an African Slave.

    Science.gov (United States)

    Lounsbery, Anne

    2000-01-01

    Alexander Pushkin, Russia's most celebrated literary figure, descended from an African slave. On both parents' sides, he was related to Avram Petrovich Gannibal, who was born to an African prince and abducted to become a slave to a Russian diplomat. Pushkin chose to pride himself on both his aristocratic life and his African ancestry. (SM)

  19. "In the Footsteps of Alexander the Great" PBS Series. Teacher's Guide.

    Science.gov (United States)

    Corporation for Public Broadcasting, Washington, DC.

    This teacher's guide correlates with the Public Broadcasting Service (PBS) television series "In the Footsteps of Alexander the Great" hosted by historian Michael Wood. The four episodes of the series are entitled: "Son of God"; "Lord of Asia"; "Across the Hindu Kush"; and "To the Ends of the Earth." The guide consists of four core units related…

  20. Holocene morphogenesis of Alexander the Great's isthmus at Tyre in Lebanon

    Science.gov (United States)

    Marriner, Nick; Morhange, Christophe; Meulé, Samuel

    2007-05-01

    In 332 B.C., Alexander the Great constructed an ≈1,000-m-long causeway to seize the offshore island of Tyre. The logistics behind this engineering feat have long troubled archaeologists. Using the Holocene sedimentary record, we demonstrate that Alexander's engineers cleverly exploited a shallow proto-tombolo, or sublittoral sand spit, to breach the offshore city's defensive impregnability. We elucidate a three-phase geomorphological model for the spit's evolution. Settled since the Bronze Age, the area's geological record manifests a long history of natural and anthropogenic forcings. (i) Leeward of the island breakwater, the maximum flooding surface (e.g., drowning of the subaerial land surfaces by seawater) is dated ≈8000 B.P. Fine-grained sediments and brackish and marine-lagoonal faunas translate shallow, low-energy water bodies at this time. Shelter was afforded by Tyre's elongated sandstone reefs, which acted as a 6-km natural breakwater. (ii) By 6000 B.P., sea-level rise had reduced the dimensions of the island from 6 to 4 km. The leeward wave shadow generated by this island, allied with high sediment supply after 3000 B.P., culminated in a natural wave-dominated proto-tombolo within 1-2 m of mean sea level by the time of Alexander the Great (4th century B.C.). (iii) After 332 B.C., construction of Alexander's causeway entrained a complete anthropogenic metamorphosis of the Tyrian coastal system.

  1. De luchtvaart van Alexander de Grote in de verbeelding der Middeleeuwen.

    NARCIS (Netherlands)

    Schmidt, Victor Michael

    1988-01-01

    The story of Alexander the Great's Aerial Flight holds a special position among the manifold legendary traditions around the famous world conqueror that were known during the Middle Ages, since no other legend of his miraculous life was represented so often in art as this one. According to the legen

  2. Alexander Pechersky Testifies: an Open Page of Sobibor Death Camp History

    Directory of Open Access Journals (Sweden)

    Lev S. Simkin

    2013-01-01

    Full Text Available Here, the author introduces the interrogation of the witness Alexander Aronovich Pechersky, the leader of the German death camp Sobibor Revolt during the World War II. Special attention is attached to the daily life of the death camp. The picture of revolt preparation was completed

  3. A review of the contributions of Dr. Alexander F. H. Goetz to imaging spectroscopy

    NARCIS (Netherlands)

    Ustin, S.; Macdonald, J.; Schaepman, M.E.

    2006-01-01

    All aspects of the science and engineering of imaging spectrometry have been advanced by the work of Dr. Alexander F.H. Goetz over the past 30 years. Dr. Goetz¿s pioneering efforts were among the first to realize that it was feasible to obtain laboratory like spectra from space that would quantify e

  4. Old Age, the Ancient Military, and Alexander's Army: Positive Examples for a Graying America.

    Science.gov (United States)

    Kebric, Robert B.

    1988-01-01

    Presents examples from ancient Greece and Rome illustrating working aged and intergenerational dependence. Describes normal active participation of elderly as officers and common soldiers in ancient military as example of their capabilities. Notes that Alexander the Great's army, in particular, depended on contributions of older men. (Author/NB)

  5. Alexander Cameron Rutherford: A Gentleman and a Scholar. Documents in the Classroom.

    Science.gov (United States)

    Hodysh, Henry W.

    2000-01-01

    Provides information about Alexander Cameron Rutherford, a provincial politician. Includes a letter written by Rutherford in 1912 that provides insights into his responsibilities to the general public, information about Rutherford himself, the economic conditions of Alberta, Canada in 1912, and information about the individual to whom it was…

  6. Planar Serial Manipulator Motion Synthesis

    Institute of Scientific and Technical Information of China (English)

    Yanhui Wei; Han Han; Zepeng Wang; Xin Liu; Guangchun Li

    2015-01-01

    This paper deals with the universal serial manipulator on the inverse kinematics problem of plane type, the fast working space solution method, and the obstacle avoidance path planning method. With the vector projection as the main constraint condition of the target, it proposes a general form of the inverse kinematics solution which does not depend on the robot configuration of freedom degree. By identifying the target vector direction maximum and minimum workspace boundary and determining the destination vector by thick search on the workspace boundary method, an expressing method of the polar coordinate form of work space is then introduced. Finally, according to the form of plane trajectory planning for obstacle avoidance problem, the method of solving the inverse kinematics solution of the concave and convex forms of the safe obstacle avoidance area is improved. The simulation results verify that the proposed method has feasibility and generality.

  7. Obituary: Alexander (Andy) Franz Lubenow, 1956-2005

    Science.gov (United States)

    Buie, Marc William

    2006-12-01

    Alexander (Andy) Franz Lubenow, Program Coordinator at the Space Telescope Science Institute, was diagnosed with cancer of the gallbladder, pancreas, and liver in May 2005 and died on 29 September 2005. He was forty-nine. Andy was born to Bodo and Helen Lubenow in St. Paul, Minnesota on 4 January 1956. In 1964 at the age of eight, he moved with his family to Buenos Aires, Argentina, and attended the American Community School there until returning with his family in 1973 to St. Paul. Argentina had a big impact on Andy's future as an astronomer. He later recalled how he had observed and was puzzled by the "upside-down" appearance of the Moon in the southern hemisphere. In Argentina, he built his first telescope using a mirror he had ground himself. He never parted ways with that instrument. Andy did not follow a standard educational track. He spent two years at St. Olaf College in Northfield, Minnesota, before transferring to the University of Minnesota, where he earned his bachelor's degree and began work towards a master's degree in astrophysics. Later he transferred to the University of Illinois at Urbana-Champaign, where he remained until Dr. Peter Stockman hired him to work on the Hubble Space Telescope project. While in school, he worked as a teacher's assistant, taught night school, and gave demonstrations of stargazing. He was an excellent teacher and had a flair for writing. He later wrote articles for a sailing magazine and a pilot's magazine. Andy was a very practical, meticulous, and steady worker, attributes that he combined with an understated and dry sense of humor. He was always able to find a way through a problem, no matter how sticky. If a job required him to roll up his sleeves and get it done through hard work, he would persevere. Nevertheless, he was always on the lookout for an easier way. He had no patience for being forced to deal with stupid things for stupid reasons. At work at the Space Telescope Science Institute (STScI), Andy was

  8. 47 CFR 95.671 - Serial number.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Serial number. 95.671 Section 95.671 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO... number. The serial number of each CB transmitter must be engraved on the transmitter chassis....

  9. Serial Position Functions in General Knowledge

    Science.gov (United States)

    Kelley, Matthew R.; Neath, Ian; Surprenant, Aimée M.

    2015-01-01

    Serial position functions with marked primacy and recency effects are ubiquitous in episodic memory tasks. The demonstrations reported here explored whether bow-shaped serial position functions would be observed when people ordered exemplars from various categories along a specified dimension. The categories and dimensions were: actors and age;…

  10. The Serial Murderer's Motivations: An Interdisciplinary Review.

    Science.gov (United States)

    DeHart, Dana D.; Mahoney, John M.

    1994-01-01

    Defines serial killer as individual who murders two or more victims over an extended period of time, ranging from days to years, with the crimes often being sexually motivated. Reviews existing motivational theories of serial murder and proposes additional explications from range of disciplines. Presents suggestions for future research and…

  11. Modus operandi of female serial killers.

    Science.gov (United States)

    Wilson, W; Hilton, T

    1998-04-01

    The modus operandi of female serial killers was examined from a chronology of 58 cases in America and 47 cases in 17 other countries, compiled over 25-year intervals. Female serial killers in other countries accounted for a disproportionately greater number of victims, but those in America managed a longer killing career when associated with a low profile modus operandi. PMID:9621726

  12. Serial Cohabitation and the Marital Life Course

    Science.gov (United States)

    Lichter, Daniel T.; Qian, Zhenchao

    2008-01-01

    Using cohort data from the National Longitudinal Survey of Youth, this paper tracks the experiences of "serial cohabitors." Results indicate that only a minority of cohabiting women (about 15%-20%) were involved in multiple cohabitations. Serial cohabitations were overrepresented among economically disadvantaged groups, especially those with low…

  13. Modus operandi of female serial killers.

    Science.gov (United States)

    Wilson, W; Hilton, T

    1998-04-01

    The modus operandi of female serial killers was examined from a chronology of 58 cases in America and 47 cases in 17 other countries, compiled over 25-year intervals. Female serial killers in other countries accounted for a disproportionately greater number of victims, but those in America managed a longer killing career when associated with a low profile modus operandi.

  14. Serial killers with military experience: applying learning theory to serial murder.

    Science.gov (United States)

    Castle, Tammy; Hensley, Christopher

    2002-08-01

    Scholars have endeavored to study the motivation and causality behind serial murder by researching biological, psychological, and sociological variables. Some of these studies have provided support for the relationship between these variables and serial murder. However, the study of serial murder continues to be an exploratory rather than explanatory research topic. This article examines the possible link between serial killers and military service. Citing previous research using social learning theory for the study of murder, this article explores how potential serial killers learn to reinforce violence, aggression, and murder in military boot camps. As with other variables considered in serial killer research, military experience alone cannot account for all cases of serial murder. Future research should continue to examine this possible link.

  15. Serial killers with military experience: applying learning theory to serial murder.

    Science.gov (United States)

    Castle, Tammy; Hensley, Christopher

    2002-08-01

    Scholars have endeavored to study the motivation and causality behind serial murder by researching biological, psychological, and sociological variables. Some of these studies have provided support for the relationship between these variables and serial murder. However, the study of serial murder continues to be an exploratory rather than explanatory research topic. This article examines the possible link between serial killers and military service. Citing previous research using social learning theory for the study of murder, this article explores how potential serial killers learn to reinforce violence, aggression, and murder in military boot camps. As with other variables considered in serial killer research, military experience alone cannot account for all cases of serial murder. Future research should continue to examine this possible link. PMID:12150084

  16. Clinical application of serial operations with preserving spleen

    Institute of Scientific and Technical Information of China (English)

    Hong-Chi Jiang; Bei Sun; Hai-Quan Qiao; Jun Xu; Da-Xun Piao; Hang Yin

    2001-01-01

    AIM: To evaluate the clinical application of serial operations with preservation of spleen. METHODS: Serial operations with preserving spleen were performed on 211 cases in our hospital from 1980 to 2000.The patient's age ranged from 13 to 56 years, averaging 3years. Diseases included splenic injury in 171 cases, portal hypertension in 9 cases, splenic cyst in 10 cases, and the lesion of pancreatic body and tail in 21 cases. RESULTS: All the cases were cured, and 129 patients were followedup from 3 months to 3 years with the leukocyte phagocytosis test, detection of immunoglubin, CT, 99mTc scanning and ultrasonogrsphy. The results were satisfactory. CONCLUSION: The operations with preserving spleen were safe, feasible, and worth of clinical application.

  17. Serial powering of pixel modules

    CERN Document Server

    Stockmanns, Tobias; Hügging, Fabian Georg; Peric, I; Runólfsson, O; Wermes, Norbert

    2003-01-01

    Modern pixel detectors for the next generation of high-energy collider experiments like LHC use readout electronics in deep sub- micron technology. Chips in this technology need a low supply voltage of 2-2.5 V alongside high current consumption to achieve the desired performance. The high supply current leads to significant voltage drops in the long and low mass supply cables so that voltage fluctuations at the chips are induced, when the supply current changes. This problem scales with the number of modules when connected in parallel to the power supplies. An alternative powering scheme connects several modules in series resulting in a higher supply voltage but a lower current consumption of the chain and therefore a much lower voltage drop in the cables. In addition the amount of cables needed to supply the detector is vastly reduced. The concept and features of serial powering are presented and studies of the implementation of this technology as an alternative for the ATLAS pixel detector are shown. In par...

  18. Background instrumental music and serial recall.

    Science.gov (United States)

    Nittono, H

    1997-06-01

    Although speech and vocal music are consistently shown to impair serial recall for visually presented items, instrumental music does not always produce a significant disruption. This study investigated the features of instrumental music that would modulate the disruption in serial recall. 24 students were presented sequences of nine digits and required to recall the digits in order of presentation. Instrumental music as played either forward or backward during the task. Forward music caused significantly more disruption than did silence, whereas the reversed music did not. Some higher-order factor may be at work in the effect of background music on serial recall.

  19. The Alexander Technique and musicians: a systematic review of controlled trials

    OpenAIRE

    Klein, Sabine; Bayard, Claudine; Wolf, Ursula

    2014-01-01

    BACKGROUND: Musculoskeletal disorders, stress and performance anxiety are common in musicians. Therefore, some use the Alexander Technique (AT), a psycho-physical method that helps to release unnecessary muscle tension and re-educates non-beneficial movement patterns through intentional inhibition of unwanted habitual behaviours. According to a recent review AT sessions may be effective for chronic back pain. This review aimed to evaluate the evidence for the effectiveness of AT sessions o...

  20. Alexander Duality for Functions: the Persistent Behavior of Land and Water and Shore

    CERN Document Server

    Edelsbrunner, Herbert

    2011-01-01

    This note contributes to the point calculus of persistent homology by extending Alexander duality to real-valued functions. Given a perfect Morse function $f: S^{n+1} \\to [0,1]$ and a decomposition $S^{n+1} = U \\cup V$ such that $M = \\U \\cap V$ is an $n$-manifold, we prove elementary relationships between the persistence diagrams of $f$ restricted to $U$, to $V$, and to $M$.

  1. Geomagnetic Measurement on Reference Point at the Airport Alexander the Great Skopje

    OpenAIRE

    Krstevski, Vladko

    2011-01-01

    For purposes of this Master thesis, measurements were made of total magnetic field on the airport "Alexander the Great", specifically in and around runway airport. Were selected 40 reference measurement points, paying particular emphasis on the threshold of the runway (threshold 16 and 34) where the density of reference points are greatest. Measurements were carried out in excellent weather, sunny day temperature of 20 degrees Celsius. During the measurements wer...

  2. The birth of Russian intelligentsia from the spirit of the enlightenment: Alexander Radishchev

    OpenAIRE

    Subotić Milan

    2009-01-01

    This text is the second part of a study about Alexander Radishchev, one of the leading representatives of Enlightenment in Russia's XVIII Century. Starting with explanation of the 'enlightened absolutism' of Catherine the Great, the author analyses the political and social ideas presented in Radishchev's book Journey from St. Petersburg to Moscow. Considering Radishchev as a 'father of Russian intelligentsia', the author stress that Radishchev's social criticism anticipated the later phenomen...

  3. Russia and Great Britain in the historian’s fate: Alexander Savin

    OpenAIRE

    Antonina Sharova

    2013-01-01

    This article examines the biography of the historian Alexander Nikolaevich Savin (1873-1923), a specialist in English agrarian history of the 16th and 17th centuries. Based on archival sources, the published and unpublished writings of the historian, reminiscences about him, his diaries and his correspondence, this article focuses on the significance of two countries–Great Britain and Russia—for his personal and intellectual life

  4. The birth of Russian intelligentsia from the spirit of the enlightenment: Alexander Radishchev

    Directory of Open Access Journals (Sweden)

    Subotić Milan

    2009-01-01

    Full Text Available This text is the second part of a study about Alexander Radishchev, one of the leading representatives of Enlightenment in Russia's XVIII Century. Starting with explanation of the 'enlightened absolutism' of Catherine the Great, the author analyses the political and social ideas presented in Radishchev's book Journey from St. Petersburg to Moscow. Considering Radishchev as a 'father of Russian intelligentsia', the author stress that Radishchev's social criticism anticipated the later phenomenon of 'dissidence'.

  5. FIVE UNPUBLISHED COINS OF ALEXANDER THE GREAT AND HIS SUCCESSORS IN THE RHODES UNIVERSITY COLLECTION

    OpenAIRE

    J.D. Snowball; W.D. Snowball

    2012-01-01

    The article briefly discusses the economic and political significance of the Alexander III (“the Great”) type silver tetradrachm and publishes three of his coins currently held by the Rhodes University Classics Museum. Based on stylistic elements, they are classified as from the Amphipolis and Arados mints and were probably minted during his lifetime. Two further tetradrachms from the empires of Alexander’s successors, Ptolemy II and Seleucus IV, are also published.

  6. Ex Occidente Imperium. Alexander the Great and the Rise of the Maurya Empire

    OpenAIRE

    Fauconnier, Bram

    2015-01-01

    Since the nineteenth century, many authors have seen the campaign of Alexander the Great in the Punjab as a pivotal moment in the history of the Indian subcontinent. British historians writing during the apex of Britain’s colonial rule perceived it as the coming of Western culture and civilisation. Nationalistic Indian historians saw the Maurya Empire, which was established shortly after Alexander’s incursion, as a patriotic reaction to the foreign oppressor. This paper discusses both hist...

  7. 'The tropics make it difficult to mope': The imaginative geography of Alexander Payne's The Descendants (2011)

    OpenAIRE

    Sánchez-Palencia, Carolina

    2015-01-01

    This paper analyses the cinematic landscape of The Descendants (Payne, 2011) by engaging with Edward Said's concept of "imaginative geographies" (Orientalism, 1978), a theoretical approach that addresses the interaction between the material and the symbolic in spatial representation. I also draw from Henri Lefebvre (The Production of Space, 1974) to explain how Alexander Payne renders space and subjectivity as mutually constitutive. The Descendants' powerful analogies between family ties and ...

  8. Reflection in Russian public opinion accession to the throne of Emperor Alexander II

    Directory of Open Access Journals (Sweden)

    Maxim N. Krot

    2016-03-01

    Full Text Available The article deals with the perception of Russian society coming to the throne of Emperor Alexander II in 1855. The author analyzes the internal and external situation in Russia in this period, identifying the most significant factors that influenced the public's attitude to the new monarch, and the expectations that were associated with his coming to power. The article draws parallels between the initial period of the reign of the two liberal Russian monarchs of the XIX century – Alexander I and Alexander II, most clearly expressed not so much in the circumstances of their accession, but in the public mood that prevailed in the country. It presents a broad picture of the "awakening" of public consciousness and activity after the stagnation and oppression of the preceding reign, which was reflected primarily in an effort to think freely and to discuss pressing issues facing the country, as well as contribute to the supreme power in the modernization of social and political relations, awareness where necessary, at this time it becomes clearly. The author identifies semantic levels of social consciousness of the period, indicating the particular circumstances that have shaped them. Much attention is paid to the influence of Russian society of the Crimean War, which in many ways was the starting point of social upheaval transformed in 1855 from a national-patriotic in the socio-political. The author points out that at this time has unique conditions for overcoming the contradictions between state and society and their successful cooperation in the reform of the country. This suggests a significant, perhaps - the crucial role of the public in the selection of the vector conversion of Russia, which has become a feature of the reign of Alexander II.

  9. Gratifications of Daytime TV Serial Viewers.

    Science.gov (United States)

    Compesi, Ronald J.

    1980-01-01

    The gratifications identified by viewers of the daytime television serial "All My Children" were (in rank order): entertainment, habit, convenience, social utility, relaxation or escape from problems, escape from boredom, and reality exploration or advice. (GT)

  10. Terabit/s serial optical communications

    DEFF Research Database (Denmark)

    Oxenløwe, Leif Katsuo; Galili, Michael; Mulvad, Hans Christian Hansen;

    2009-01-01

    We report on an experimental demonstration of a 1.28 Tbit/s serial data generation and demultiplexing and discuss the prospects of upgrading other essential functionalities to 1.28 Tbit/s.......We report on an experimental demonstration of a 1.28 Tbit/s serial data generation and demultiplexing and discuss the prospects of upgrading other essential functionalities to 1.28 Tbit/s....

  11. Plutarcho Aleksandras: interpretacijos problemos. Plutarch‘s Alexander: Problems of Interpretation

    Directory of Open Access Journals (Sweden)

    Nijolė Juchnevičienė

    2010-01-01

    Full Text Available Alexander‘ s character and his activities occupy a special position in the works of Plutarch. Alexander’s Life is the second largest life in the corpus, there are two elaborated speeches on him included into Moralia, and he is often mentioned in the other pieces of this corpus. The speeches, usually called De Alexandri Magni fortuna aut virtute (A and B, were written by the young Plutarch. They belong to the epideictic rhetoric tradition and are based on the opposition between the hero’s ἀρετήand τύχη, which was in general not favor­able to him. According to Plutarch, all Alexander’s life was a struggle between τύχη and ἀρ��τή. The speeches reveal the impressive portrait of Alexander not only as an invincible warrior, but also as a philosopher in arms, whose immortal achievements are the best proof of his ἀρετή. He managed to overcome the unfavorable τύχη and to civilize the world of the barbarians. There is a difference of interpretation of the character between the speeches and the Life. Alexander is not as perfect there as in the speeches, but his character still is in the center of the narration. The motive of ἀρετήvs. τύχη is also present and Plutarch still sticks to his earlier opinion that Alexander’s ἀρετή, not τύχη was the decisive factor in his life. Plutarch notices the changes in Alexander and his negative features, but at the same time, he tries to explain and extenuate his behavior pointing out to Alexander’s extreme valuation of his δόξα, which he regarded more important than the royal power and the life itself. In my opinion, Alexander’s attitude to his δόξα reveals the difference between the heroes of the pair, Alexander and Caesar. This differ­ence is also expanded in the detailed description of the post-mortal status and fate of their bodies, the effect that reminiscence of them makes on the living. I agree with the opinion, that Caesar is

  12. Teachers' professional development needs and current practices at the Alexander Science Center School

    Science.gov (United States)

    Gargus, Gerald Vincent

    This investigation represents an in-depth understanding of teacher professional development at the Alexander Science Center School, a dependent charter museum school established through a partnership between the California Science Center and Los Angeles Unified School District. Three methods of data collection were used. A survey was distributed and collected from the school's teachers, resulting in a prioritized list of teacher professional development needs, as well as a summary of teachers' opinions about the school's existing professional development program. In addition, six key stakeholders in the school's professional development program were interviewed for the study. Finally, documents related to the school's professional development program were analyzed. Data collected from the interviews and documents were used to develop an understand various components of the Alexander Science Center School's professional development program. Teachers identified seven areas that had a high-priority for future professional development including developing skills far working with below-grade-level students, improving the analytical skills of student in mathematics, working with English Language Learners, improving students' overall reading ability levels, developing teachers' content-area knowledge for science, integrating science across the curriculum, and incorporating hands-on activity-based learning strategies to teach science. Professional development needs identified by Alexander Science Center School teachers were categorized based on their focus on content knowledge, pedagogical content knowledge, or curricular knowledge. Analysis of data collected through interviews and documents revealed that the Alexander Science Center School's professional development program consisted of six venues for providing professional development for teachers including weekly "banked time" sessions taking place within the standard school day, grade-level meetings, teacher support

  13. [The serial murder: a few theoretical perspectives].

    Science.gov (United States)

    Leistedt, S; Linkowski, P

    2011-01-01

    Despite numbers of publications and effort to try to establish the definition, the classification, the epidemiology, the clinical aspects and the psychopathology of serial killers, a universal consensus seems to say the least. Crime, though reduced in some countries, appears to impact more and more consistent worldwide, generating controversial ideas and a multitude of possible explanations. The serial killer usually presents as a caucasian man, aged between 20 and 40 years, often embedded socially and in his family, but with serious psychiatric, personal and especially family history. Usually acting alone, the serial killer plans a crime well in advance, but sometimes within the scope of impulsivity for a minority, the victim not being previously selected. In the latter case, an actual mental illness like psychosis is found. It is clear from numerous psychopathological studies conducted so far that most serial killers are defined as psychopathic sexual sadists, whose childhood was difficult, if not flouted, punctuated by physical and psychological violence situations. In addition, pervasive fantasies combined with thoughts of death, sex and violence are as much in common with the original acts of which they are the instigators. Beyond a relentless media that is constantly watering the public with stories and pictures depicting them as such, serial killers remain an enigma. We can therefore attempt to answer the various questions raised by this phenomenon, the way these people operate and how we can curb the rise, thanks to the neurobiological and neurophysiological approaches that science offers us. PMID:21834446

  14. [The serial murder: a few theoretical perspectives].

    Science.gov (United States)

    Leistedt, S; Linkowski, P

    2011-01-01

    Despite numbers of publications and effort to try to establish the definition, the classification, the epidemiology, the clinical aspects and the psychopathology of serial killers, a universal consensus seems to say the least. Crime, though reduced in some countries, appears to impact more and more consistent worldwide, generating controversial ideas and a multitude of possible explanations. The serial killer usually presents as a caucasian man, aged between 20 and 40 years, often embedded socially and in his family, but with serious psychiatric, personal and especially family history. Usually acting alone, the serial killer plans a crime well in advance, but sometimes within the scope of impulsivity for a minority, the victim not being previously selected. In the latter case, an actual mental illness like psychosis is found. It is clear from numerous psychopathological studies conducted so far that most serial killers are defined as psychopathic sexual sadists, whose childhood was difficult, if not flouted, punctuated by physical and psychological violence situations. In addition, pervasive fantasies combined with thoughts of death, sex and violence are as much in common with the original acts of which they are the instigators. Beyond a relentless media that is constantly watering the public with stories and pictures depicting them as such, serial killers remain an enigma. We can therefore attempt to answer the various questions raised by this phenomenon, the way these people operate and how we can curb the rise, thanks to the neurobiological and neurophysiological approaches that science offers us.

  15. Stochastic modeling of a serial killer.

    Science.gov (United States)

    Simkin, M V; Roychowdhury, V P

    2014-08-21

    We analyze the time pattern of the activity of a serial killer, who during 12 years had murdered 53 people. The plot of the cumulative number of murders as a function of time is of "Devil's staircase" type. The distribution of the intervals between murders (step length) follows a power law with the exponent of 1.4. We propose a model according to which the serial killer commits murders when neuronal excitation in his brain exceeds certain threshold. We model this neural activity as a branching process, which in turn is approximated by a random walk. As the distribution of the random walk return times is a power law with the exponent 1.5, the distribution of the inter-murder intervals is thus explained. We illustrate analytical results by numerical simulation. Time pattern activity data from two other serial killers further substantiate our analysis.

  16. Rar o koshmare ili intervju, kotorogo ne bõlo / Alexander Rahr ; interv. Jana Toom

    Index Scriptorium Estoniae

    Rahr, Alexander

    2008-01-01

    Tallinnas toimus 2007. a. aprillisündmustele pühendatud V Kodurahu foorum. Esinejate hulgas oli ka tuntud Saksa politoloog Alexander Rahr, kes Eestisse saabus loenguga teemal "Saksamaa-Venemaa: strateegilise partnerluse ülesehitamise kogemused". Lääneriigid on veendunud, et NATO ja Euroopa Liidu laienemine tugevdab ja konsolideerib demokraatlikku Euroopat, kuid Venemaad uude Euroopasse mitteintegreerides teeb Lääs strateegilise vea, mille eest tasumine jääb järgnevatele põlvedele. Kahjuks aitab eneseisolatsioonile kaasa ka Moskva tegevus. Euroopa ühise kodu idee, vanade ja uute Euroopa Liidu liikmete suhted Venemaaga, teemad, mis vajaksid kogu Euroopa koostööd

  17. DENT, Alexander Sebastian. River of tears: country music, memory and modernity in Brasil

    OpenAIRE

    Sautchuk, João Miguel

    2014-01-01

    River of tears: country music, memory and modernity in Brasil, de Alexander Sebastian Dent (professor de antropologia na George Washington University, EUA), consiste numa análise etnográfica da música rural mediatizada das regiões Sudeste, Centro-Oeste e Sul do Brasil, que busca compreender a modernidade brasileira e como ela se configura a partir de uma relação contínua e dialética com o passado idealizado na representação da ruralidade. Este brasilianista denomina de “música rural” precisam...

  18. Alexander Fleming, citrated blood and penicillin: paths not pursued and applications delayed.

    Science.gov (United States)

    Mortimer, P P

    2009-12-01

    Ninety years ago Alexander Fleming (later to discover penicillin) jointly wrote a description of the use of indirect transfusions of citrated blood at a World War 1 (WW1) base hospital. It was the longest series yet to be published, incorporating what was then a novel procedure for treating war casualties. Returning to civilian life Fleming, a qualified surgeon and bacteriologist, chose a different career path, and not until the wars of the late 1930s were the advances in transfusion in WW1 fully incorporated into the management of trauma and haemorrhage. Like penicillin, the benefits of indirect transfusion were only slowly realised.

  19. Das Ganze der Natur Alexander von Humboldt und das romantische Forschungsprogramm

    Directory of Open Access Journals (Sweden)

    Kristian Köchy

    2002-10-01

    Full Text Available Article in German, Abstracts in English, German and Spanish. The wholeness of natureAlexander von Humboldt and the romantic research programIt does not seem to be clear whether there is a tight junction between the humboldian science and the romantic research program. But by recognizing the principal aim of Humboldts concept – the representation of nature as a whole – one can see how Humboldts view has been developed in contact with romantic ideas. This investigation analyses Humboldts research program in consideration of its main features and the special relations between science, philosophy of nature, feeling of nature, history and art.

  20. Local move formulae for \\\\the Alexander polynomials of $n$-knots

    OpenAIRE

    Ogasa, Eiji

    2005-01-01

    It is well-known:Suppose there are three 1-dimensional links $K_+$, $K_-$, $K_0$ such that $K_+$, $K_-$, and $K_0$ coincide out of a 3-ball $B$ trivially embedded in $S^3$ and that $K_+\\cap B$, $K_-\\cap B$, and $K_0\\cap B$ are drawn as follows. Then $\\Delta_{K_+}-\\Delta_{K_+}=(t-1)\\cdot\\Delta_{K_0}$, where $\\Delta_{K}$ is the Alexander polynomial of $K$. We know similar formulae of other invariants of 1-dimensional knots and links. (The Jones polynomial etc.) It is natural to ask: Suppose the...

  1. "Die Toten reiten schnelle." Literarische Zitate in Briefen von und an Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Ingo Schwarz

    2007-04-01

    Full Text Available Article in GermanAbstract in English and GermanAlexander von Humboldt and his correspondents liked to enrich or embellish their letters with quotations from classic works of ancient literature as well as from recent poems, plays, or novels. This paper tries to show that references to literature were very often used in order to express thoughts and feelings more clearly not so much for impressing the recipients of letters with high education. In educated circles a good knowledge of ancient and modern works of literature was a standard requirement, which often allowed the letter writers to use quotations in a playful manner.

  2. The presentation of the results of Alexander von Humboldt's voyage to Carlos IV

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Puig-Samper

    2016-05-01

    Full Text Available Resumen  Desde nuestras primeras investigaciones sobre la estancia de Alexander von Humboldt en España siempre nos sorprendió la ausencia de una mínima relación posterior del sabio prusiano con la corona española y sus autoridades. Iniciada una nueva investigación, encontramos que efectivamente se produjo el envío de un primer trabajo a Carlos IV desde Roma acompañado de una carta de gratitud por la protección recibida durante su viaje americano y de sumisión a la corona española, que ahora presentamos.   Summary Ever since our first research into Alexander von Humboldt's stay in Spain, the absence of an ensuing relationship between the wise Prussian and the Spanish Crown and Authorities had always surprised us. On starting new research, we found that indeed he sent his first work to Carlos IV from Rome accompanied by a letter of gratitude for the protection he had received during his American trip and submission to the Spanish Crown, which we now present. This first literary fruit of his voyage, which Alexander von Humboldt alluded to in the letter is the first instalment of his work Plantes Équinoxiales, Recueillies au Mexique, dans l’ile de Cuba, dans les provinces de Caracas, de Cumana etc., published in Paris in 1805.   Zusammenfassung Seit unseren ersten Forschungen über den Aufenthalt Alexander von Humboldts in Spanien hat uns das Fehlen einer hieran anschließenden Beziehung des preußischen Wissenschaftlers mit der spanischen Krone und ihren Behörden erstaunt. Im Laufe einer erneuten Aufnahme der Forschung, haben wir nun entdeckt, dass Humboldt in der Tat von Rom aus eine erste Arbeit an Karl IV gesandt hatte, zusammen mit einem Schreiben des Dankes (für den während der amerikanischen Reise erhaltenen Schutz sowie seiner Unterordnung unter die spanische Krone, das wir nun präsentieren. Das erste literarische Ergebnis seiner Reise, auf das Humboldt in diesem Brief verweist, ist der erste Faszikel seines Werkes

  3. The eyeball killer: serial killings with postmortem globe enucleation.

    Science.gov (United States)

    Coyle, Julie; Ross, Karen F; Barnard, Jeffrey J; Peacock, Elizabeth; Linch, Charles A; Prahlow, Joseph A

    2015-05-01

    Although serial killings are relatively rare, they can be the cause of a great deal of anxiety while the killer remains at-large. Despite the fact that the motivations for serial killings are typically quite complex, the psychological analysis of a serial killer can provide valuable insight into how and why certain individuals become serial killers. Such knowledge may be instrumental in preventing future serial killings or in solving ongoing cases. In certain serial killings, the various incidents have a variety of similar features. Identification of similarities between separate homicidal incidents is necessary to recognize that a serial killer may be actively killing. In this report, the authors present a group of serial killings involving three prostitutes who were shot to death over a 3-month period. Scene and autopsy findings, including the unusual finding of postmortem enucleation of the eyes, led investigators to recognize the serial nature of the homicides.

  4. The eyeball killer: serial killings with postmortem globe enucleation.

    Science.gov (United States)

    Coyle, Julie; Ross, Karen F; Barnard, Jeffrey J; Peacock, Elizabeth; Linch, Charles A; Prahlow, Joseph A

    2015-05-01

    Although serial killings are relatively rare, they can be the cause of a great deal of anxiety while the killer remains at-large. Despite the fact that the motivations for serial killings are typically quite complex, the psychological analysis of a serial killer can provide valuable insight into how and why certain individuals become serial killers. Such knowledge may be instrumental in preventing future serial killings or in solving ongoing cases. In certain serial killings, the various incidents have a variety of similar features. Identification of similarities between separate homicidal incidents is necessary to recognize that a serial killer may be actively killing. In this report, the authors present a group of serial killings involving three prostitutes who were shot to death over a 3-month period. Scene and autopsy findings, including the unusual finding of postmortem enucleation of the eyes, led investigators to recognize the serial nature of the homicides. PMID:25682709

  5. Alexander Dalgarno

    Science.gov (United States)

    Fox, Jane L.

    Alex Dalgarno saved my career. I entered the Graduate School at Harvard in the Chemistry Department in September of 1973 from the University of Michigan, where I had (unfortunately) majored in Chemistry. Chemistry is considered a "laboratory science" but I had no talent in the laboratory. I had merely fallen in love with the ideal gas law in high school, and I had stubbornly allowed this to determine my course of studies, most of which had nothing to do with the ideal gas law, and much of which was focused on laboratory studies...

  6. Recalling visual serial order for verbal sequences

    NARCIS (Netherlands)

    Logie, R.H.; Saito, S.; Morita, A.; Varma, S.; Norris, D.

    2016-01-01

    We report three experiments in which participants performed written serial recall of visually presented verbal sequences with items varying in visual similarity. In Experiments 1 and 2 native speakers of Japanese recalled visually presented Japanese Kanji characters. In Experiment 3, native speakers

  7. Serial Position Curves in Free Recall

    Science.gov (United States)

    Laming, Donald

    2010-01-01

    The scenario for free recall set out in Laming (2009) is developed to provide models for the serial position curves from 5 selected sets of data, for final free recall, and for multitrial free recall. The 5 sets of data reflect the effects of rate of presentation, length of list, delay of recall, and suppression of rehearsal. Each model…

  8. Identität und Differenz Goethes Faust und Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Heinz Krumpel

    2007-04-01

    Full Text Available Article in German, Abstracts in English, Spanish and GermanIn the article “Identity and difference between Goethe`s Faust and Alexander von Humboldt” the issue of how much Faust is contained in Humboldt and in which way Goethe`s Faust has to be related to Alexander von Humboldt is discussed. Here the connection of activity, knowledge and vision as well as the relationship between humans and nature are central to the examination. Goethe and Humboldt were greatly influenced by the enlightenment. Their ideas and visions show us today that modernity is an incomplete project. In Goethe`s Faust the question of the essence of mankind is posed because there is a hint of Faust and Mephisto in each human. With Humboldt those principles acted among other things as a driving force for greater productitivity and the extraction of knowledge. Even though Faust did not fail in his bet with Mephisto, on the other hand he also did not win. Humboldt, however, would have won the bet. Considering the global ecological crisis and regional conflicts today the idea of the relation of Goethe´s Faust and Humboldt has an astonishing relevance.

  9. Book review: An Introduction to Audio Content Analysis: Applications in Signal Processing and Music Informatics by Alexander Lerch

    DEFF Research Database (Denmark)

    Sturm, Bob L.

    2013-01-01

    A critical review of the book: An Introduction to Audio Content Analysis: Applications in Signal Processing and Music Informatics, by Alexander Lerch, October 2012, Wiley-IEEE Press. ISBN: 978-1-118-26682-3, Hardcover, 272 pages, 503 references. List price $125.00......A critical review of the book: An Introduction to Audio Content Analysis: Applications in Signal Processing and Music Informatics, by Alexander Lerch, October 2012, Wiley-IEEE Press. ISBN: 978-1-118-26682-3, Hardcover, 272 pages, 503 references. List price $125.00...

  10. Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia.

    Science.gov (United States)

    Davis, K Rennis; Vadakkan, D Thomas; Krishnakumar, E V; Anas, A Muhammed

    2015-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by alveolar accumulation of surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages. Mainstay of treatment is whole lung lavage, which requires general anesthesia. Herein, we report a case of primary PAP, successfully treated with serial bronchoscopic lung lavages under local anesthesia. PMID:25814803

  11. Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia

    OpenAIRE

    K Rennis Davis; D Thomas Vadakkan; Krishnakumar, E. V.; A Muhammed Anas

    2015-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by alveolar accumulation of surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages. Mainstay of treatment is whole lung lavage, which requires general anesthesia. Herein, we report a case of primary PAP, successfully treated with serial bronchoscopic lung lavages under local anesthesia.

  12. Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia

    Directory of Open Access Journals (Sweden)

    K Rennis Davis

    2015-01-01

    Full Text Available Pulmonary alveolar proteinosis (PAP is a rare disease, characterized by alveolar accumulation of surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages. Mainstay of treatment is whole lung lavage, which requires general anesthesia. Herein, we report a case of primary PAP, successfully treated with serial bronchoscopic lung lavages under local anesthesia.

  13. Serial position markers in space: visuospatial priming of serial order working memory retrieval.

    Science.gov (United States)

    De Belder, Maya; Abrahamse, Elger; Kerckhof, Emma; Fias, Wim; van Dijck, Jean-Philippe

    2015-01-01

    Most general theories on serial order working memory (WM) assume the existence of position markers that are bound to the to-be-remembered items to keep track of the serial order. So far, the exact cognitive/neural characteristics of these markers have remained largely underspecified, while direct empirical evidence for their existence is mostly lacking. In the current study we demonstrate that retrieval from verbal serial order WM can be facilitated or hindered by spatial cuing: begin elements of a verbal WM sequence are retrieved faster after cuing the left side of space, while end elements are retrieved faster after cuing the right side of space. In direct complement to our previous work--where we showed the reversed impact of WM retrieval on spatial processing--we argue that the current findings provide us with a crucial piece of evidence suggesting a direct and functional involvement of space in verbal serial order WM. We outline the idea that serial order in verbal WM is coded within a spatial coordinate system with spatial attention being involved when searching through WM, and we discuss how this account can explain several hallmark observations related to serial order WM. PMID:25611595

  14. Serial position markers in space: visuospatial priming of serial order working memory retrieval.

    Directory of Open Access Journals (Sweden)

    Maya De Belder

    Full Text Available Most general theories on serial order working memory (WM assume the existence of position markers that are bound to the to-be-remembered items to keep track of the serial order. So far, the exact cognitive/neural characteristics of these markers have remained largely underspecified, while direct empirical evidence for their existence is mostly lacking. In the current study we demonstrate that retrieval from verbal serial order WM can be facilitated or hindered by spatial cuing: begin elements of a verbal WM sequence are retrieved faster after cuing the left side of space, while end elements are retrieved faster after cuing the right side of space. In direct complement to our previous work--where we showed the reversed impact of WM retrieval on spatial processing--we argue that the current findings provide us with a crucial piece of evidence suggesting a direct and functional involvement of space in verbal serial order WM. We outline the idea that serial order in verbal WM is coded within a spatial coordinate system with spatial attention being involved when searching through WM, and we discuss how this account can explain several hallmark observations related to serial order WM.

  15. 7 CFR 29.9205 - Identification number (farm serial number).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Identification number (farm serial number). 29.9205 Section 29.9205 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... number (farm serial number). The serial number assigned to an individual farm by the appropriate...

  16. English Literature: A Student's Guide to Serial Bibliographies.

    Science.gov (United States)

    McGill Univ., Montreal (Quebec). McLennan Library.

    This selected guide to serial bibliographies covering English language literature is based on an essay bibliography by David E. Pownall. Other bibliographies of serial bibliographies which were consulted include "A Reference Guide to English Studies,""Periodicals Containing Reviews and Bibliographies,""Serial Bibliographies in the Humanities and…

  17. Automated detection of multiple sclerosis lesions in serial brain MRI

    Energy Technology Data Exchange (ETDEWEB)

    Llado, Xavier; Ganiler, Onur; Oliver, Arnau; Marti, Robert; Freixenet, Jordi [University of Girona, Computer Vision and Robotics Group, Girona (Spain); Valls, Laia [Dr. Josep Trueta University Hospital, Department of Radiology, Girona (Spain); Vilanova, Joan C. [Girona Magnetic Resonance Center, Girona (Spain); Ramio-Torrenta, Lluis [Dr. Josep Trueta University Hospital, Institut d' Investigacio Biomedica de Girona, Multiple Sclerosis and Neuroimmunology Unit, Girona (Spain); Rovira, Alex [Vall d' Hebron University Hospital, Magnetic Resonance Unit, Department of Radiology, Barcelona (Spain)

    2012-08-15

    Multiple sclerosis (MS) is a serious disease typically occurring in the brain whose diagnosis and efficacy of treatment monitoring are vital. Magnetic resonance imaging (MRI) is frequently used in serial brain imaging due to the rich and detailed information provided. Time-series analysis of images is widely used for MS diagnosis and patient follow-up. However, conventional manual methods are time-consuming, subjective, and error-prone. Thus, the development of automated techniques for the detection and quantification of MS lesions is a major challenge. This paper presents an up-to-date review of the approaches which deal with the time-series analysis of brain MRI for detecting active MS lesions and quantifying lesion load change. We provide a comprehensive reference source for researchers in which several approaches to change detection and quantification of MS lesions are investigated and classified. We also analyze the results provided by the approaches, discuss open problems, and point out possible future trends. Lesion detection approaches are required for the detection of static lesions and for diagnostic purposes, while either quantification of detected lesions or change detection algorithms are needed to follow up MS patients. However, there is not yet a single approach that can emerge as a standard for the clinical practice, automatically providing an accurate MS lesion evolution quantification. Future trends will focus on combining the lesion detection in single studies with the analysis of the change detection in serial MRI. (orig.)

  18. Automated detection of multiple sclerosis lesions in serial brain MRI

    International Nuclear Information System (INIS)

    Multiple sclerosis (MS) is a serious disease typically occurring in the brain whose diagnosis and efficacy of treatment monitoring are vital. Magnetic resonance imaging (MRI) is frequently used in serial brain imaging due to the rich and detailed information provided. Time-series analysis of images is widely used for MS diagnosis and patient follow-up. However, conventional manual methods are time-consuming, subjective, and error-prone. Thus, the development of automated techniques for the detection and quantification of MS lesions is a major challenge. This paper presents an up-to-date review of the approaches which deal with the time-series analysis of brain MRI for detecting active MS lesions and quantifying lesion load change. We provide a comprehensive reference source for researchers in which several approaches to change detection and quantification of MS lesions are investigated and classified. We also analyze the results provided by the approaches, discuss open problems, and point out possible future trends. Lesion detection approaches are required for the detection of static lesions and for diagnostic purposes, while either quantification of detected lesions or change detection algorithms are needed to follow up MS patients. However, there is not yet a single approach that can emerge as a standard for the clinical practice, automatically providing an accurate MS lesion evolution quantification. Future trends will focus on combining the lesion detection in single studies with the analysis of the change detection in serial MRI. (orig.)

  19. A Survey of Electronic Serials Managers Reveals Diversity in Practice

    Directory of Open Access Journals (Sweden)

    Laura Costello

    2014-09-01

    Full Text Available A Review of: Branscome, B. A. (2013. Management of electronic serials in academic libraries: The results of an online survey. Serials Review, 39(4, 216-226. http://dx.doi.org/10.1016/j.serrev.2013.10.004 Abstract Objective – To examine industry standards for the management of electronic serials and measure the adoption of electronic serials over print. Design – Survey questionnaire. Setting – Email lists aimed at academic librarians working in serials management. Subjects – 195 self-selected subscribers to serials email lists. Methods – The author created a 20 question survey that consisted primarily of closed-ended questions pertaining to the collection demographics, staff, budget, and tools of serials management groups in academic libraries. The survey was conducted via Survey Monkey and examined using the analytical features of the tool. Participants remained anonymous and the survey questions did not ask them to reveal identifiable information about their libraries. Main Results – Collection demographics questions revealed that 78% of surveyed librarians estimated that print-only collections represented 40% or fewer of their serials holdings. The author observed diversity in the factors that influence print to digital transitions in academic libraries. However 71.5% of participants indicated that publisher technology support like IP authentication was required before adopting digital subscriptions. A lack of standardization also marked serials workflows, department responsibilities, and department titles. The author did not find a correlation between serials budget and the enrollment size of the institution. Participants reported that they used tools from popular serials management vendors like Serials Solutions, Innovative Interfaces, EBSCO, and Ex Libris, but most indicated that they used more than one tool for serials management. Participants specified 52 unique serials management products used in their libraries. Conclusion

  20. Stochastic modeling of a serial killer

    CERN Document Server

    Simkin, M V

    2012-01-01

    We analyze the time pattern of the activity of a serial killer, who during twelve years had murdered 53 people. The plot of the cumulative number of murders as a function of time is of "Devil's staircase" type. The distribution of the intervals between murders (step length) follows a power law with the exponent of 1.4. We propose a model according to which the serial killer commits murders when neuronal excitation in his brain exceeds certain threshold. We model this neural activity as a branching process, which in turn is approximated by a random walk. As the distribution of the random walk return times is a power law with the exponent 1.5, the distribution of the inter-murder intervals is thus explained. We confirm analytical results by numerical simulation.

  1. Data Driven Hierarchical Serial Scene Classification Framework

    Institute of Scientific and Technical Information of China (English)

    FENG Wen-Gang

    2014-01-01

    Scene classification is a complicated task, because it includes much content and it is difficult to capture its distribution. A novel hierarchical serial scene classification framework is presented in this paper. At first, we use hierarchical feature to present both the global scene and local patches containing specific objects. Hierarchy is presented by space pyramid match, and our own codebook is built by two different types of words. Secondly, we train the visual words by generative and discriminative methods respectively based on space pyramid match, which could obtain the local patch labels efficiently. Then, we use a neural network to simulate the human decision process, which leads to the final scene category from local labels. Experiments show that the hierarchical serial scene image representation and classification model obtains superior results with respect to accuracy.

  2. Speciation despite globally overlapping distributions in Penicillium chrysogenum: the population genetics of Alexander Fleming’s lucky fungus

    Science.gov (United States)

    Eighty years ago, Alexander Fleming described the antibiotic effects of a fungus that had contaminated his bacterial culture, kick starting the antimicrobial revolution. The fungus was later ascribed to a globally distributed asexual species, Penicillium chrysogenum. Recently, the species has been...

  3. Reliance on Arbitral Awards in Title VII Suits: Implications of Alexander v. Gardner-Denver and Public Employment Cases

    Science.gov (United States)

    Miller, David R.

    1976-01-01

    The 1974 Supreme Court decision in Alexander v. Gardner-Denver Co. resolved the controversy in the lower courts concerning the finality of an arbitration award when concurrent or subsequent court action is brought under Title VII. For journal availability see HE 508 844. (LBH)

  4. Growing Community: The Impact of the Stephanie Alexander Kitchen Garden Program on the Social and Learning Environment in Primary Schools

    Science.gov (United States)

    Block, Karen; Gibbs, Lisa; Staiger, Petra K.; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

    2012-01-01

    This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has…

  5. Brookhaven Lab physicists Edward Beebe and Alexander Pikin win 'Brightness Award' for achievement in ion source physics and technology

    CERN Document Server

    2003-01-01

    "Edward Beebe and Alexander Pikin, physicists at the U.S. Department of Energy's Brookhaven National Laboratory, have been awarded the Ion Source Prize, known as the "Brightness Award," which recognizes and encourages innovative and significant recent achievements in the fields of ion source physics and technology" (1 page).

  6. Monitor Forest Fires with FY Serial Satellites

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Remote sensing as the measure to monitor disasters has the advantage of temporal resolution and large scale. Since "5.6 catastrophe" in 1987, China began to monitor forest fires broadly. In the summer of 2002, many forest/grass fires occurred in the Daxing'anling Mountains, and the damage was very heavy. In the forest fires fighting, the meteorological satellites play an important role in monitoring the fires. Especially the FY serial meteorological satellites have the advantage of large scale monitorin...

  7. Lipidic phase membrane protein serial femtosecond crystallography

    OpenAIRE

    Johansson, LC; Arnlund, D.; White, TA; Katona, G.; DePonte, DP; Weierstall, U.; Doak, RB; Shoeman, RL; Lomb, L; Malmerberg, E.; Davidsson, J; Nass, K.; Liang, MN; Andreasson, J.; Dell'Aquila, A.

    2012-01-01

    X-ray free electron laser (X-FEL)-based serial femtosecond crystallography is an emerging method with potential to rapidly advance the challenging field of membrane protein structural biology. Here we recorded interpretable diffraction data from micrometer-sized lipidic sponge phase crystals of the Blastochloris viridis photosynthetic reaction center delivered into an X-FEL beam using a sponge phase micro-jet.

  8. Serial correlation in the Italian futures market

    Science.gov (United States)

    Bianco, Simone; Reno, Roberto

    2005-05-01

    We study the serial correlation of high-frequency intraday returns on the Italian stock index futures (FIB30) in the period 2000-2002. We adopt three different methods of analysis: the spectral density via Fast Fourier Transform, Detrended Fluctuation Analysis (DFA) and the Variance Ratio test. We find that intraday autocorrelation is mostly negative for time scales lower than 20 minutes, but we support the efficiency of the Italian futures market.

  9. Serials collection management in recessionary times

    CERN Document Server

    Lawson, Karen G

    2013-01-01

    Strategic planning, collaboration, continual stewardship, best practices, and re-engineering can provide librarians with a toolkit of innovative strategies that meets the worst of economic times with bold, persistent experimentation.This book covers the implications for libraries of a broad range of technological and economic challenges. These challenges include the fallout from the global economic crisis, the positioning of usage statistics, the advent of open access scholarship, database management, responding to budgetary constrictions and general access to serials.Taken as

  10. Fungal myositis in children: serial ultrasonographic findings

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Jung Hwa; Lee, Hee Jung; Choi, Jin Soo [Keimyung University School of Medicine, Daegu (Korea, Republic of)

    2003-08-01

    To evaluate serial ultrasonographic findings of fungal myositis in children. Eleven lesions caused by fungal myositis and occurring in six children were included in this study. Eight lesions in five children were histopathologically proven and the other three were clinically diagnosed. Serial ultrasonographic findings were retrospectively evaluated in terms of size, location, margin, internal echotexture and adjacent cortical change occurring during the follow-up period ranging from five days to two months. Three patients (50%) had multiple lesions. The sites of involvment were the thigh (n=4), calf (n=3), chest wall (n=2), abdominal wall (n=1) and forearm (n=1). Initially, diffuse muscular swelling was revealed, with ill-defined hypoechoic lesions confined to the muscle layer (n=8). Follow-up examination of eight lesions over a period of 5-10 days showed that round central echogenic lesions were surrounded by previous slightly echogenic lesions (n=6, 75%). Long-term follow-up of five lesions over a two-month period revealed periosteal thickening in one case (20%), and the peristence of echogenic solid nodules in four (80%). Pathologic examination showed that the central lesions correlated with a fungus ball and the peripheral slightly echogenic lesions corresponded to hematoma and necrosis. Serial ultrasonographic findings of fungal myositis in children revealed relatively constant features in each case. In particular, the findings of muscular necrosis and a fungus ball over a period of 5-14 days were thought to be characteristic.

  11. Las construcciones verbales seriales en mapuche

    Directory of Open Access Journals (Sweden)

    Ana Fernández-Garay

    2009-06-01

    Full Text Available Este artículo analiza las construcciones verbales seriales (CVS del mapudungun, lengua indígena hablada en el sur de la República Argentina, sobre todo en las provincias de La Pampa, Neuquén, Río Negro y Chubut. Los estudios tradicionales del mapudungun han tratado los verbos conformadospor dos o más raíces verbales como lexemas compuestos. A partir de la perspectiva tipológica, que define las construcciones verbales seriales como una secuencia de verbos que funciona como un predicado único, sin presentar elementos coordinantes ni subordinantes entre ellos, se las analiza estableciendo los distintos tipos de CVS, sus valores semánticos, así como su frecuencia de aparición en los corpora sobre los que se basanuestro trabajo. -- This article analyzes the serial verb constructions (SVC of Mapudungun, an indigenous language spoken in the southern region of Argentina —mainly in the provinces of La Pampa, Neuquén, Río Negro y Chubut.Traditional investigations of Mapudungun have considered verbs constituted by two or more verbal roots as complex lexemes. From a typological trend, which defines SVC as a sequence of verbs that functions as a unique predicate, without presenting coordination or subordination elements betweenthem, we analyze Mapudungun SVC and, thus, establish a typology, their semantic values and the appearance frequency in the corpora we gathered for this investigation.

  12. Serial Pixel Analog-to-Digital Converter

    Energy Technology Data Exchange (ETDEWEB)

    Larson, E D

    2010-02-01

    This method reduces the data path from the counter to the pixel register of the analog-to-digital converter (ADC) from as many as 10 bits to a single bit. The reduction in data path width is accomplished by using a coded serial data stream similar to a pseudo random number (PRN) generator. The resulting encoded pixel data is then decoded into a standard hexadecimal format before storage. The high-speed serial pixel ADC concept is based on the single-slope integrating pixel ADC architecture. Previous work has described a massively parallel pixel readout of a similar architecture. The serial ADC connection is similar to the state-of-the art method with the exception that the pixel ADC register is a shift register and the data path is a single bit. A state-of-the-art individual-pixel ADC uses a single-slope charge integration converter architecture with integral registers and “one-hot” counters. This implies that parallel data bits are routed among the counter and the individual on-chip pixel ADC registers. The data path bit-width to the pixel is therefore equivalent to the pixel ADC bit resolution.

  13. Die Entstehung einer Legende. Alexander von Humboldts angeblicher Ausspruch über Salzburg.

    Directory of Open Access Journals (Sweden)

    Robert Hoffmann

    2006-04-01

    Full Text Available Article in German, Abstract in English.This paper sheds light on the history of the quotation “I regard the environs of Salzburg, Naples, and Constantinople as the most beautiful on earth”, which is usually attributed to Alexander von Humboldt. The author shows that Humboldt’s alleged praise of Salzburg first appeared around 1870, and thus the quotation cannot be regarded as authentic. As a local legend it was meant to connect permanently the famous name of Humboldt with that of the growing centre of tourism. The circumstances under which the quotation found its way into the literature remain to be investigated; however, it seems clear that this can be seen as a typical example of what Eric Hobsbawm has called „invention of tradition“. Invented traditions – this might comfort the tourist industry of Salzburg – have particularly long lives.

  14. Neuromusicology or musiconeurology? Omni-art in Alexander Scriabin as a fount of ideas

    Directory of Open Access Journals (Sweden)

    Lazaros C. Triarhou

    2016-03-01

    Full Text Available Science can uncover neural mechanisms by looking at the work of artists. The ingenuity of a titan of classical music, the Russian composer Alexander Scriabin (1872–1915, in combining all the sensory modalities into a polyphony of aesthetical experience, and his creation of a chord based on fourths rather than the conventional thirds are proposed as putative points of departure for insight, in future studies, into the neural processes that underlie the perception of beauty, individually or universally. Scriabin’s Omni-art was a new synthesis of music, philosophy and religion, and a new aesthetic language, a unification of music, vision, olfaction, drama, poetry, dance, image and conceptualization, all governed by logic, in the quest for the integrative action of the human mind toward a higher reality of which music is only a component.

  15. Neuromusicology or Musiconeurology? “Omni-art” in Alexander Scriabin as a Fount of Ideas

    Science.gov (United States)

    Triarhou, Lazaros C.

    2016-01-01

    Science can uncover neural mechanisms by looking at the work of artists. The ingenuity of a titan of classical music, the Russian composer Alexander Scriabin (1872–1915), in combining all the sensory modalities into a polyphony of aesthetical experience, and his creation of a chord based on fourths rather than the conventional thirds are proposed as putative points of departure for insight, in future studies, into the neural processes that underlie the perception of beauty, individually or universally. Scriabin’s “Omni-art” was a new synthesis of music, philosophy and religion, and a new aesthetic language, a unification of music, vision, olfaction, drama, poetry, dance, image, and conceptualization, all governed by logic, in the quest for the integrative action of the human mind toward a “higher reality” of which music is only a component. PMID:27014167

  16. Alexander Tomov (1930-2009: A Founder of the Astronomical Photoelectric Photometry in Bulgaria [In Bulgarian

    Directory of Open Access Journals (Sweden)

    N. Tomov

    2011-08-01

    Full Text Available This paper describes the work of Dr. Alexander Tomov on establishment and equipment of the Astronomical Observatory of Belogradchik. Tomov’s research activity in that observatory is commented as well. The official opening of the observatory took place on July 21st, 1965. During the period 1966-1969 a monitoring program for determining the orbits of artificial satellites was successfully realized. Constructing a new building expanded later observatory. In mid-1969 the observatory was supplied by 60 cm reflector optical system ‘Cassegrain’, produced by Carl Zeiss in Germany; it was the biggest telescope in Bulgaria at that time. In the period 1970-1973 a modern single-channel photoelectric UBV photometer was constructed and put in operation. In 1976 the Belogradchik observatory joined with the Institute of Astronomy of the Bulgarian Academy of Sciences. In the second half of seventies and early eighties hundreds of galaxies were studied.

  17. Neuromusicology or Musiconeurology? "Omni-art" in Alexander Scriabin as a Fount of Ideas.

    Science.gov (United States)

    Triarhou, Lazaros C

    2016-01-01

    Science can uncover neural mechanisms by looking at the work of artists. The ingenuity of a titan of classical music, the Russian composer Alexander Scriabin (1872-1915), in combining all the sensory modalities into a polyphony of aesthetical experience, and his creation of a chord based on fourths rather than the conventional thirds are proposed as putative points of departure for insight, in future studies, into the neural processes that underlie the perception of beauty, individually or universally. Scriabin's "Omni-art" was a new synthesis of music, philosophy and religion, and a new aesthetic language, a unification of music, vision, olfaction, drama, poetry, dance, image, and conceptualization, all governed by logic, in the quest for the integrative action of the human mind toward a "higher reality" of which music is only a component. PMID:27014167

  18. Political Economy, Alexander Von Humboldt, and Mexico’s 1810 and 1910 Revolutions

    Directory of Open Access Journals (Sweden)

    Richard Weiner

    2010-08-01

    Full Text Available This article, which is informed by Steve Pincus’ scholarship on revolution, engages in the novelendeavor of comparing Mexico’s 1810 and 1910 Revolutions. The article explores broad parallelsbetween the two upheavals, and highlights significant features of Mexico’s Revolutions thatscholars have ignored. Alexander von Humboldt’s Ensayo político sobre el reino de la NuevaEspaña proved to be influential in both of Mexico’s Revolutions, albeit in distinct ways in eachcase. Conflicts over political economy were also central aspects of each Revolution. Theseeconomic disagreements sometimes pitted revolutionists against traditionalists, and sometimesdivided revolutionists against each other. Even if revolutionists differed in terms of economicvisions, they were all “statists” in the sense that they designated an important role for governmentin fostering economic and social modernization.

  19. The birth of Russian intelligentsia from the spirit of enlightenment: Alexander Radishchev (I

    Directory of Open Access Journals (Sweden)

    Subotić Milan

    2008-01-01

    Full Text Available This text is the first part of a larger study about Alexander Radishchev, one of the leading representatives of Enlightenment in Russia's XVIII Century. Analyzing Voltaire's and Diderot's relationship with Catherine II, the Empress of Russia, in the Introduction of this article, the author formulates the reasons for thematization of Russian reception of Enlightenment. Since Radishchev is considered as 'the father of Russian intelligentsia', different approaches to the meaning of the concept of 'Russian intelligentsia' are considered in the first chapter. Radishchev's biography is interpreted in the second chapter in order to facilitate the understanding of his ideas. Interpretation of his ideas, as well as of Catherina's 'enlightened absolutism', will be subject to further consideration in the second part of the study.

  20. Alexander Numan (1780-1852 en de veredeling van de Nederlandse schapenrassen

    Directory of Open Access Journals (Sweden)

    Jesper Oldenburger

    2015-10-01

    Full Text Available Alexander Numan and the improvement of the Dutch sheep breedsAlexander Numan’s life and work provide a splendid illustration of the early nineteenth-century Dutch scientist’s view of the role of science and scientists in society. As a professor at the Utrecht veterinary school he spent a substantial part of his time on a practical endeavour: the improvement of the wool quality of the Dutch sheep breeds. He did not confine his activities to the scientific aspects only, but aimed to obtain the active involvement of all relevant stakeholders in his project: the government, the sheep farmers and the wool industry.In the literature, Numan’s project is seen as a failure: the stakeholders were skeptical about his project from the beginning, as wool improvement was seen as a misguided aim. The Dutch wool industry was perfectly satisfied with the quality of the Dutch wool, and the trend among sheep breeders was to improve their sheeps’ meat meat quality rather than their wool. Eventually, the government withdrew its indispensable support.Nevertheless, Numan clung doggedly to the aim he had set himself, and the question we want to answer is this paper is why. We argue that the answer is to be found in Numan’s view of the role of science in society. His motives were not merely economic, but, first and foremost, of a moral nature. Wool quality, for him, was a measure of the level of civilization a country had reached. Social and cultural progress went hand in hand with the availability of higher quality clothing, the raw materials for which the Dutch sheep were as yet unable to provide. By providing these materials Numan was convinced to contribute directly to the well-being and cultural enhancement of the Dutch population, an objective that was characteristic of the self-fashioned private and public persona of the early nineteenth-century Dutch scientist.

  1. Serial observations in Crohn`s disease: can hydro-MRI replace follow-through examinations?; Verlaufskontrolle des Morbus Crohn: Kann die Hydro-MRT die fraktionierte Magen-Darm-Passage ersetzen?

    Energy Technology Data Exchange (ETDEWEB)

    Schunk, K. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Metzmann, U. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Kersjes, W. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Schadmand-Fischer, S. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Kreitner, K.F. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Duchmann, R. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Protzer, U. [Mainz Univ. (Germany). 1. Medizinische Klinik und Poliklinik; Wanitschke, R. [Mainz Univ. (Germany). 1. Medizinische Klinik und Poliklinik; Thelen, M. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie

    1997-05-01

    To compare the value of hydro-MRI with follow-through examinations in the follow-up of Crohn`s disease. 22 patients known to be suffering from Crohn`s disease were examined via 1.5 T-MR system; an oral contrast examination using 1000 ml of a 2.5% mannitol solution was performed in all patients. T{sub 2}-weighted TSE sequences and T{sub 1}-weighted SE sequences were performed before and after the intravenous injection of Gd-DTPA. To reduce movement artifacts caused by peristalsis of the gut, intravenous injection of 40 mg Buscopan was given. The findings of hydro-MRI were compared with the follow-through examinations. In the upper gastrointestinal tract, the follow-through examination showed clear advantages compared with hydro-MRI for the demonstration of inflammatory changes in the gut; Hydro-MRI was, however, somewhat more reliable in the ileum and colon. It was also more sensitive than the follow-through for the demonstration of enteric fistulae (four as compared with two cases), and in demonstration extraluminal changes (free fluid in six against zero, and inflammatory adherent loops (four against zero)). Amongst the 22 patients, hydro-MRI was equal (in 10) or better (in 8) than the follow-through examination for demonstrating the intestinal manifestations of Crohn`s disease, and follow-through was better in only four. For follow-up of Crohn`s disease, hydro-MRI is at least as good as follow-through examination, and is even preferable, because of the absence of radiation exposure of the usually young patients. (orig.) [Deutsch] Die Aussagekraft der Hydro-Magnetresonanztomographie (Hydro-MRT) bei der Verlaufskontrolle eines M. Crohn sollte mit der der fraktionierten Magen-Darm-Passage (MDP) verglichen werden. 22 Patienten mit einem bekannten M. Crohn wurden an einem 1,5 T-MR-System untersucht; bei allen wurde eine orale Darmkontrastierung mit 1000 ml einer 2,5%igen Mannitolloesung durchgefuehrt. Zum Einsatz kamen T{sub 2}-gewichtete TSE-Sequenzen sowie T{sub 1

  2. Rapid serial visual presentation design for cognition

    CERN Document Server

    Spence, Robert

    2013-01-01

    A powerful new image presentation technique has evolved over the last twenty years, and its value demonstrated through its support of many and varied common tasks. Conceptually, Rapid Serial Visual Presentation (RSVP) is basically simple, exemplified in the physical world by the rapid riffling of the pages of a book in order to locate a known image. Advances in computation and graphics processing allow RSVP to be applied flexibly and effectively to a huge variety of common tasks such as window shopping, video fast-forward and rewind, TV channel selection and product browsing. At its heart is a

  3. Serial Dissection of Parasite Gene Families.

    Science.gov (United States)

    Bzik, David J

    2016-05-01

    Calcium ion signaling regulates central aspects of the biology controlling stage and life cycle transitions of apicomplexan parasites. In the current issue of Infection and Immunity, Long and coworkers (S. Long, Q. Wang, and L. D. Sibley, Infect Immun 84:1262-1273, 2016, http://dx.doi.org/10.1128/IAI.01173-15) describe a powerful genetic system enabling reliable serial genetic dissection of a large gene family encoding novel calcium-dependent protein kinases (CDPKs) that provides new insights into the roles of CDPKs during Toxoplasma gondii infection. PMID:26953326

  4. Berglinien im Vergleich. Bemerkungen zu einem klimageografischen Diagramm Alexander von Humboldts

    Directory of Open Access Journals (Sweden)

    Birgit Schneider

    2013-04-01

    Full Text Available Zusammenfassung Der Artikel analysiert aus bildwissenschaftlicher und historischer Perspektive die unveröffentlichte Skizze zu einem Bergdiagramm aus dem handschriftlichen Nachlass Alexander von Humboldts. Das mehrfach beklebte Skizzenblatt stand im Zentrum klimageografischer Fragestellungen nach den Gründen für die weltweit unterschiedlich hohen Schneegrenzen in Gebirgen. Aufgrund des unfertigen, skizzenhaften Charakters des Diagramms lassen sich Fragen über den Forschungskontext des Diagramms, den epistemischen Stellenwert zeichnerischer Praktiken sowie über die heuristische Rolle der Berge und ihrer charakteristischen Profillinien in Humboldts Forschungen stellen. Gezeigt wird, wie das visuelle Denken und das Interesse Humboldts an neuen grafischen Methoden zu einer wichtigen Bedingung wurden, um die holistische Synopsis der Welt als ökologisches System erforschen und darstellen zu können. Abstract The article analyses from a visual studies and historical perspective the unpublished sketch of a mountain profile found among the handwritten papers of Alexander von Humboldt’s estate. The small sheet of sketches, with its pasted additions, was at the heart of climatic-geographic academic enquiry into the reasons for worldwide differences in the levels of mountain snow lines. The unfinished, sketchy nature of the diagramme raises questions about its research context, about the epistemic value of draughtsmanship practice and about the heuristic role of mountains and their characteristic profiles in Humboldt’s research. It becomes evident how Humboldt’s visual logic and his interest in new forms of graphics became important factors in investigation and depiction of the world as an ecological system. Resumen En el artículo se analizan los bocetos sin publicar de perspectivas históricas y de la ciencia de la imagen del diagrama montañoso de las obras póstumas escritas a mano de Alexander von Humboldt. La hoja de bocetos pegada de

  5. Breaking the indexing ambiguity in serial crystallography.

    Science.gov (United States)

    Brehm, Wolfgang; Diederichs, Kay

    2014-01-01

    In serial crystallography, a very incomplete partial data set is obtained from each diffraction experiment (a `snapshot'). In some space groups, an indexing ambiguity exists which requires that the indexing mode of each snapshot needs to be established with respect to a reference data set. In the absence of such re-indexing information, crystallographers have thus far resorted to a straight merging of all snapshots, yielding a perfectly twinned data set of higher symmetry which is poorly suited for structure solution and refinement. Here, two algorithms have been designed for assembling complete data sets by clustering those snapshots that are indexed in the same way, and they have been tested using 15,445 snapshots from photosystem I [Chapman et al. (2011), Nature (London), 470, 73-77] and with noisy model data. The results of the clustering are unambiguous and enabled the construction of complete data sets in the correct space group P63 instead of (twinned) P6322 that researchers have been forced to use previously in such cases of indexing ambiguity. The algorithms thus extend the applicability and reach of serial crystallography.

  6. Galileo - The Serial-Production AIT Challenge

    Science.gov (United States)

    Ragnit, Ulrike; Brunner, Otto

    2008-01-01

    The Galileo Project is one of the most demanding projects of ESA, being Europe's autarkic navigation system and a constellation composed of 30 satellites. This presentation points out the different phases of the project up to the full operational capability and the corresponding launch options with respect to launch vehicles as well as launch configurations. One of the biggest challenges is to set up a small serial 'production line' for the overall integration and test campaign of satellites. This production line demands an optimization of all relevant tasks, taking into account also backup and recovery actions. A comprehensive AIT concept is required, reflecting a tightly merged facility layout and work flow design. In addition a common data management system is needed to handle all spacecraft related documentation and to have a direct input-out flow for all activities, phases and positions at the same time. Process optimization is a well known field of engineering in all small high tech production lines, nevertheless serial production of satellites are still not the daily task in space business and therefore new concepts have to be put in place. Therefore, and in order to meet the satellites overall system optimization, a thorough interface between unit/subsystem manufacturing and satellite AIT must be realized to ensure a smooth flow and to avoid any process interruption, which would directly lead to a schedule impact.

  7. 著名亚洲学者钢和泰%A Brief Review of Alexander von Stael-Holstein——A Great Scholar in Asiatic Studies

    Institute of Scientific and Technical Information of China (English)

    王启龙

    2008-01-01

    @@ "Stael-Holstein"(1897-1937) should be a memorable name in Asian academic field, but it's a pity that today it has been almost forgotten by us. His full name in German is Alexander von Stael-Holstein.

  8. [Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003

    Index Scriptorium Estoniae

    Garleff, Michael, 1940-

    2011-01-01

    Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003. Heidelberg : Universitätsverlag Winter, 2007

  9. Representation of the serial killer on the Italian Internet.

    Science.gov (United States)

    Villano, P; Bastianoni, P; Melotti, G

    2001-10-01

    The representation of serial killers was examined from the analysis of 317 Web pages in the Italian language to study how the psychological profiles of serial killers are described on the Italian Internet. The correspondence analysis of the content of these Web pages shows that in Italy the serial killer is associated with words such as "monster" and "horror," which suggest and imply psychological perversion and aberrant acts. These traits are peculiar for the Italian scenario.

  10. Representation of the serial killer on the Italian Internet.

    Science.gov (United States)

    Villano, P; Bastianoni, P; Melotti, G

    2001-10-01

    The representation of serial killers was examined from the analysis of 317 Web pages in the Italian language to study how the psychological profiles of serial killers are described on the Italian Internet. The correspondence analysis of the content of these Web pages shows that in Italy the serial killer is associated with words such as "monster" and "horror," which suggest and imply psychological perversion and aberrant acts. These traits are peculiar for the Italian scenario. PMID:11783573

  11. Unterwegs zum Weltbewußtsein. Alexander von Humboldts Wissenschaftsverständnis und die Entstehung einer ethisch fundierten Weltanschauung

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2000-10-01

    Full Text Available Article in German, Abstracts in English and Spanish. Towards Global Consciousness. Alexander von Humboldt's Conception of Science and the emerging ethical Weltanschauung. In the context of recent reflections upon global ethics (Hans Küng, global democracy (Otfried Höffe and a new cultural situation after the end of the Cold War (Clifford Geertz, Alexander von Humboldt's concept of global consciousness (Weltbewußtsein marks a decisive point in the ungoing process of the construction of a new ethics of globalization. This article tries to show how Humboldt's transdisciplinary and intercultural conception of sience as WorldWideWeb integrates Kant's philosophical visions of global political institutions and formulates a critique of the non-empirical foundations of Hegel's teleological Weltanschauung. From his Visions of Nature and his Personal Narrative to his Cosmos, Humboldt's theory and practice of science help us to find a new ethos and new answers to the contemporary questions of divergent modernities.

  12. "Outstanding Services to Negro Health": Dr. Dorothy Boulding Ferebee, Dr. Virginia M. Alexander, and Black Women Physicians' Public Health Activism.

    Science.gov (United States)

    Gamble, Vanessa Northington

    2016-08-01

    An examination of the lives and careers of physician-activists Dorothy Boulding Ferebee (1898-1972) and Virginia M. Alexander (1899-1949) demonstrates how Black physicians in the first half of the 20th century used public health to improve the health of Black Americans and provides insights into the experiences of Black women physicians. I discuss their professional and personal backgrounds and analyze their divergent strategies to address health inequities. Ferebee used her leadership in Black women's organizations to develop public health programs and become a national advocate for Black health. Alexander, a Quaker, used her religious connections to urge Whites to combat racism in medicine. She also conducted public health research and connected it to health activism. Both were passionate advocates of health equity long before it gained prominence as a major public health issue. An analysis of their work illuminates past efforts to improve the health of Black Americans. PMID:27310348

  13. A psychological profile of a serial killer: a case report.

    Science.gov (United States)

    Dogra, T D; Leenaars, Antoon A; Chadha, R K; Manju, Mehta; Lalwani, Sanjeev; Sood, Mamta; Lester, David; Raina, Anupuma; Behera, C

    2012-01-01

    Serial killers have always fascinated society. A serial killer is typically defined as a perpetrator who murders three or more people over a period of time. Most reported cases of serial killers come from the United States and Canada. In India, there are few reported cases. We present, to the best of our knowledge, the first Indian case in the literature. The present case is of a 28-year-old man, Surinder Koli. The Department of Forensic Medicine & Toxicology, All India Institute of Medical Sciences, New Delphi handled the forensic study. We present a most unique psychological investigation into the mind of a serial killer.

  14. A psychological profile of a serial killer: a case report.

    Science.gov (United States)

    Dogra, T D; Leenaars, Antoon A; Chadha, R K; Manju, Mehta; Lalwani, Sanjeev; Sood, Mamta; Lester, David; Raina, Anupuma; Behera, C

    2012-01-01

    Serial killers have always fascinated society. A serial killer is typically defined as a perpetrator who murders three or more people over a period of time. Most reported cases of serial killers come from the United States and Canada. In India, there are few reported cases. We present, to the best of our knowledge, the first Indian case in the literature. The present case is of a 28-year-old man, Surinder Koli. The Department of Forensic Medicine & Toxicology, All India Institute of Medical Sciences, New Delphi handled the forensic study. We present a most unique psychological investigation into the mind of a serial killer. PMID:23115894

  15. Malignant sex and aggression: an overview of serial sexual homicide.

    Science.gov (United States)

    Myers, W C; Reccoppa, L; Burton, K; McElroy, R

    1993-01-01

    Serial murderers have attracted considerable attention in the popular press and criminal justice field, but scientific literature about these individuals is limited. This article provides an overview, from a psychiatric perspective, of serial sexual homicide, one type of serial killing. Characteristics of this type of murder and of these offenders are discussed. Defining qualities and diagnoses applicable to serial sexual killers are reviewed. Various etiologic theories are discussed, with emphasis on the role of fantasy and psychodynamic explanations. Governmental agencies involved in combating this type of crime, along with the role of mental health professionals in criminal profiling, are presented. Finally, the authors explore the reaction of society to this phenomenon.

  16. On the American expedition of Alexander von Humboldt (1769-1859): connection with nature, nomadic impulse and self-realization

    OpenAIRE

    Jordi García Farrero

    2015-01-01

    In this article, the author approaches the figure of Alexander von Humboldt (1769-1859) basically for two reasons. First, he is one of the leading naturalists and geographers of Romanticism, as demonstrated by the following scientific contributions: the organic unity between man and nature, and the vision of nature as a realm of freedom; secondly, his biographical trajectory is quite inspiring from a pedagogical perspective, concerning the scientific expedition he conducted along with the Fre...

  17. "Ein beschränkter Verstandesmensch ohne Einbildungskraft" Anmerkungen zu Friedrich Schillers Urteil über Alexander von Humboldt

    OpenAIRE

    Ingo Schwarz

    2006-01-01

    Article in German, Abstract in English. In a letter dated August 6, 1797 to his friend Christian Gottfried Körner, Friedrich Schiller characterized Alexander von Humboldt as a person of limited imagination, who, in spite of his numerous activities, would never be able to achieve greatness in his scientific pursuits. Yet, only in 1849 did Humboldt learn of Schiller’s opinion from the published correspondence between Schiller and Körner. Nonetheless, Humboldt declared that this basically unjust...

  18. The effectiveness of Alexander Technique on music performance and musicians’ health and well-being – a systematic review

    OpenAIRE

    Klein, Sabine D.; Bayard, Claudine; Wolf, Ursula

    2013-01-01

    Introduction Musicians often suffer injuries related to their music playing. Therefore, some use Alexander Technique (AT), a mental-physical method that facilitates to release unnecessary muscle tension and to re-educate non-beneficial movement patterns through enhanced kinaesthetic awareness. According to a recent review AT may be effective for chronic back pain [1]. This review aimed to evaluate the evidence for the effectiveness of AT lessons on music performance and musicians’ health a...

  19. Woody Allen, serial schlemiel ?

    Directory of Open Access Journals (Sweden)

    Frédérique Brisset

    2011-04-01

    Full Text Available Woody Allen a développé au fil des années une persona cinématographique de schlemiel new-yorkais aisément reconnaissable par le spectateur. Elle marque nombre de ses films, qu’il y apparaisse en tant qu’acteur ou y dirige des substituts comédiens comme déclinaisons de lui-même. Si cette figure prototypique est le fondement de la sérialité dans sa filmographie, il est des traits stylistiques qui en portent trace tout au long de son œuvre : la récurrence annuelle de ses réalisations, la signature formelle symbolisée par ses génériques à la typographie singulière, le rythme de ses dialogues ponctués d’interjections et l’usage de l’autocitation sont autant de procédés qui marquent son cinéma d’un sceau très personnel. Ils fonctionnent comme des clins d’œil au spectateur qui reçoit dès lors LE Woody Allen millésimé comme une invitation à retrouver son microcosme. Ainsi la sérialité se pose comme à la fois initiale et conséquentielle de son système filmique, processus de création unique dans le cinéma américain.Woody Allen has long constructed a cinematographic persona of schlemiel New- Yorker that the audience can easily identify. It impacts most of his films, whether he stars in them or directs “substitute” actors to impersonate his character. If this prototypical figure is the basis of seriality in his cinematography, serial stylistic features can also be found all along his career: the annual recurrence of his productions, the formal signature symbolised by the typography of his singular credit titles, his rhythmical interjection-punctuated dialogues and the use of self-quotation imprint a very personal seal upon his movies. They all work as a recognition signals for the audience who thus receive THE Woody Allen vintage as an invitation to re-enter his microcosm. Seriality is then both initial and consequential to his cinematographic system, a unique creative process in American film history.

  20. The Development of Information Policy of the Russian Empire During the Reign of Alexander II

    Directory of Open Access Journals (Sweden)

    Elena S. Ustinovich

    2015-03-01

    Full Text Available During this historical period was actively carried out the process of interaction and interdependence of the development of state power and social consciousness within the limits of formation of the state information policy. Alexander II and his inner circle, given these trends and evaluating the shortcomings of the reign of his father, after years of ignoring the power of public opinion on important socio-political and socio-economic issues, after a long ban on open discussion of the shortcomings of the actions of the authorities and of the state apparatus, deliberately stimulated the beginning of the «era of conviction». Growth of social consciousness, the press has naturally gained a strong influence on representatives of the Russian society and contributed to raising awareness of and advocate for their rights. The authority is committed to the advancement of social development, directs itself to the expansion of media freedom and on the settlement of socio-political issues through dialogue, carried out with the assistance of the media.

  1. Zum Verhältnis Charles Darwins zu Alexander v. Humboldt und Christian Gottfried Ehrenberg

    Directory of Open Access Journals (Sweden)

    Petra Werner

    2009-05-01

    Full Text Available Article in German, Abstracts in English and German.While it is well known that Charles Darwin and Alexander von Humboldt appreciated each other's work, Humboldt's influence on Darwin has not yet been thoroughly examined. The following paper shows to what extent Darwin was inspired by Humboldt's publications while writing his Origin of Species.Darwin paid special attention to Humboldt's observations on plant migration and throughout his whole scientific career he used Humboldt's books as a major source of information. In fact, Darwin's last annotations in his copy of the Personal Narrative of travels to the Equinoctial Regions of the New continent during the Years 1799-1804 date back to the last weeks of his life.On the other hand, Darwin rejected many of Humboldt's scientific conclusions. The two authors differed in their assessment of Heinrich Bronn's biological research. Finally, Darwin was dissatisfied with Humboldtís last work Cosmos because it did not contain the information he expected. Darwinís collaboration with Humboldt's travel companion Christian Gottfried Ehrenberg proved to be similarly disappointing. Darwin sent 183 samples of infusoria to Berlin, but the results of Ehrenberg's analysis did not support Darwin's theory on evolution.

  2. PRAYER AND THE "SPIRITUAL CONSTITUENT" IN THE IMAGE OF A BELOVED IN ALEXANDER PUSHKIN'S LYRIC POETRY

    Directory of Open Access Journals (Sweden)

    Elena Alexandrovna Kuchina

    2013-11-01

    Full Text Available Prayer in Alexander Pushkin's lyric poetry appears in its natural ecclesiological context. In his prayerful poems devoted to a woman the motif of turning Love into Divinity in the light of Christian understanding of Beauty plays the most important role. Pushkin's personal prayers are very close to the patristic idea. In his poem Akathist to Ekaterina Nikolaevna Karamzina Pushkin embodied the prayer-praising; in his poem I loved you — and love it may yet be Deep in my soul... he embodied the prayer-blessing; in his sonnet Madonna the reader can find benediction and in the poem To the Beauty (1832 one can feel the state of religious reverence. The heroine of these poems is considered to be a divine creature, a sacral image. In Pushkin's lyric poetry these profound evangelical ideas are renewed. The hymnologic genre and Christian divine service in his poems become obvious. The artistic embodiment of a prayer becomes possible with the help of an iconic word and image. A prayerful word in Pushkin's poems contributes to idealization of the form that evolves from emotional and sensual state to spiritual and ascetical world-view, from the artistic and figurative word to the iconic clarity.

  3. Speciation despite globally overlapping distributions in Penicillium chrysogenum: the population genetics of Alexander Fleming's lucky fungus.

    Science.gov (United States)

    Henk, D A; Eagle, C E; Brown, K; Van Den Berg, M A; Dyer, P S; Peterson, S W; Fisher, M C

    2011-10-01

    Eighty years ago, Alexander Fleming described the antibiotic effects of a fungus that had contaminated his bacterial culture, kick starting the antimicrobial revolution. The fungus was later ascribed to a putatively globally distributed asexual species, Penicillium chrysogenum. Recently, the species has been shown to be genetically diverse, and possess mating-type genes. Here, phylogenetic and population genetic analyses show that this apparently ubiquitous fungus is actually composed of at least two genetically distinct species with only slight differences detected in physiology. We found each species in air and dust samples collected in and around St Mary's Hospital where Fleming worked. Genotyping of 30 markers across the genome showed that preserved fungal material from Fleming's laboratory was nearly identical to derived strains currently in culture collections and in the same distinct species as a wild progenitor strain of current penicillin producing industrial strains rather than the type species P. chrysogenum. Global samples of the two most common species were found to possess mating-type genes in a near 1:1 ratio, and show evidence of recombination with little geographic population subdivision evident. However, no hybridization was detected between the species despite an estimated time of divergence of less than 1MYA. Growth studies showed significant interspecific inhibition by P. chrysogenum of the other common species, suggesting that competition may facilitate species maintenance despite globally overlapping distributions. Results highlight under-recognized diversity even among the best-known fungal groups and the potential for speciation despite overlapping distribution.

  4. Alexander von Humboldt und seine geognostischen Studien in Göttingen

    Directory of Open Access Journals (Sweden)

    Bernd Kölbel

    2006-04-01

    Full Text Available Article in German, Abstracts in English and German.Even before he went to Freiberg (Saxony to study with Abraham Gottlob Werner, Alexander von Humboldt had done research into geognosy and the science of salt making. The results were published in the book “Mineralogische Beobachtungen über einige Basalte am Rhein”, and in „Versuch über einige physikalische und chemische Grundsätze der Salzwerkskunde“ (1792. Humboldt’s first teachers in geognosy, J. F. Blumenbach and H. F. Link had an important impact on these early studies. Until 1795, 31% of Humboldt’s scientific work consisted of research into these fields. This paper argues that, due to Humboldt’s comprehensive knowledge of the literature on geognosy, the references to this field in Steven Jan van Geuns’s journal of a common trip along the river Rhine (1789 were directly influenced by Humboldt. Thus van Geuns’s diary contains Humboldt’s first statements on volcanism, the geognosy of basalts, and references to salt making.

  5. Alexander von Humboldt's Idea of Interconnectedness and its Relationship to Interdisciplinarity and Communication

    Directory of Open Access Journals (Sweden)

    Detlev Doherr

    2015-10-01

    Full Text Available Alexander von Humboldt, a German scientist and explorer of the 19th century, viewed the natural world holistically and described the harmony of nature among the diversity of the physical world as a conjoining between all physical disciplines. He noted in his diary: "Everything is interconnectedness." The main feature of Humboldt's pioneering work was later named "Humboldtian science", meaning the accurate study of interconnected real phenomena in order to find a definite law and a dynamic cause. Following Humboldt's idea of nature, an Internet edition of his works must preserve the author's original intention, retain an awareness of all relevant works, and still adhere to the requirements of scholarly edition. At the present time, however, the highly unconventional form of his publications has undermined the awareness and a comprehensive study of Humboldt's works. Digital libraries should supply dynamic links to sources, maps, images, graphs and relevant texts. New forms of interaction and synthesis between humanistic texts and scientific observation need to be created. Information technology is the only way to do justice to the broad range of visions, descriptions and the idea of nature of Humboldt's legacy. It finally leads to virtual research environments as an adequate concept to redesign our digital archives, not only for Humboldt's documents, but for all interconnected data.

  6. PRAYER IN ALEXANDER BLOK'S LYRIC POETRY ("A GIRL WAS SINGING IN THE CHURCH CHOIR..."

    Directory of Open Access Journals (Sweden)

    Irina Aleksandrovna Spiridonova

    2013-11-01

    Full Text Available The article examines the genre clash of a prayer and stanzas in Alexander Blok’s poem A girl was singing in the church choir... (1905. Prayer is the main ecclesiastical source, shaping the poem’s lyric model. The genre canon of stanzas with the strophes detached substantially and compositionally, transforms the central musical theme into four scene-developments linked by dissonance. Each of the strophes in A girl was singing in the church choir... has its own semantic point (prayer – singings – illusion – enlightenment and reveals a different content of the event, intensifies and develops the tragic theme of two worlds, intended and unintended substitutions, spiritual quest and time losses. Blok’s stanzas are poetic evidence of a modern man’s exit from a prayerful concentration. The model of “conflicting synthesis” of ecclesiastical and literary genres reflects the religious/mystical opposition in symbolism aesthetics and strengthens the tragic pathos of Blok’s lyric poetry.

  7. A Multilingual Monologue: Alexander Lenard’s Self-Translated Autobiography in Three Languages

    Directory of Open Access Journals (Sweden)

    Helga Lénárt-Cheng

    2015-01-01

    Full Text Available The paper investigates the question of self-translation in the work of Alexander Lenard (Lénárd Sándor. Lenard, a polyglot writer and translator, rewrote his autobiography three times, in three different languages (in German, English, and Hungarian. This process of self-translation created a fascinating web of autobiographical texts, which invite a multiscopic reading. Following in the footsteps of 18th century parodists, Lenard challenges a great number of protocols associated with life-writing. The most important among these is the authority of the proper name as a guarantee of autobiographical authenticity. To challenge the authority of the proper name Lenard purposely multiplies his own authorial identities, for example by claiming that “A. L. is only a pseudonym.” Thus, the word ‘self-plagiarism’ acquires in Lenard’s case a double meaning, implying both that the author plagiarizes his own text and that he plagiarizes his own self. The paper explains why existing theories of self-translation cannot be applied to Lenard’s texts, and why his unique case can enrich future studies of this topic.

  8. La fabrique du savoir Essai sur les carnets de voyage d'Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Marie-Noëlle Bourguet

    2006-10-01

    Full Text Available Article in French, Abstract in English.Whilst the notebook belongs to the imagery of the enlightened scientist's persona (an auxiliary tool kept by his side to be hastily scribbled with data, when at the bench or in the field, it has been given little attention by historians of science, who are used to consider its manuscript pages as a documentary resource to complement the printed text, but rarely take the notebook as a material and cultural object by itself, the history and epistemology of which is to be explored. Only recently have new trends in the historiography, by historians of printed books and reading practices, and by social and cultural historians of knowledge, called for a fresh look and opened the way for new approaches. Taking Alexander von Humboldt as a paramount example, who expressly devoted his life to "observing and recording" the world, pen in hand, this paper explores the note-taking practices at work in his travel diaries and notebooks from the perspective of the history of scientific observation and cognitive practices. Four themes are successively considered : the question of method and apprenticeship ; the timing of note-taking practices ; the nature and status of the data jotted down on the page ; finally, their uses in the production of scientific knowledge. In the back and forth movement between the observation of the world and the writing of science, the notebook stood as a crucial intellectual step and cognitive tool.

  9. Alexander Scriabin: his chronic right-hand pain and Its impact on his piano compositions.

    Science.gov (United States)

    Altenmüller, Eckart

    2015-01-01

    Alexander Scriabin was an outstanding pianist and an avant-garde composer who influenced later generations with his innovative "multimedia" conceptions of aesthetic experience. As an adolescent, he was systematically trained as a concert pianist and received lessons from Vassily Safonoff, one of the founders of the legendary Russian Piano School. At age 20, Scriabin suffered an overuse injury of his right hand when attempting to improve the sound quality of his piano touch. This injury caused a deep crisis and influenced his later composition style in his piano works. From this time on, his works were frequently dominated by unusual virtuosic use and wide spans of his left hand. Rest, restricted repertoire, and an increased focus on composition contributed to recovery; however, he always remained anxious concerning the stamina of his right hand. The case report impressively demonstrates the stressors an aspiring young pianist had to cope with at the end of the nineteenth century. Furthermore, it is a convincing example of how resource-oriented behavior and intuition lead to the improvement of health status. Differential diagnoses and the modern concept of multimodal pain therapy in chronic overuse injury will be discussed from a historical perspective.

  10. The Russian secret service and King Alexander Obrenović of Serbia (1900-1903

    Directory of Open Access Journals (Sweden)

    Rajić Suzana

    2012-01-01

    Full Text Available The period of 1900-1903 saw three phases of cooperation between the Rus­sian Secret Service (Okhrana and King Alexander Obrenović of Serbia. It is safe to say that the Secret Service operated in Serbia as an extended arm of the Russian Ministry of Foreign Affairs, i.e. of its diplomatic mission in Belgrade. Its goal was to fortify the position of Russia in Serbia after King Alexander’s wedding and the departure of his father, ex-King Milan (who abdicated in 1889 in favour of his minor son, from the country. The Serbian King, however, benefited little from the cooperation, because he did not receive assistance from the Secret Service when he needed it most. Thus, the issue of conspiracy against his life was lightly treated throughout 1902 until his assassination in 1903. In the third and last period of cooperation, from the beginning of 1902 until the King’s assassination on 11 June 1903,1 the Russian ministries of Internal and Foreign Affairs forbade the agents to receive money from the Serbian King and relieved them of any duty regarding the protection of his life. [Projekat Ministarstva nauke Republike Srbije, br. 177014: Serbian nation: Integrating and disintegrating processes

  11. Causes of ransom private railways in the Russian Empire during the reign of Alexander III

    Directory of Open Access Journals (Sweden)

    Pavel A. Gurianov

    2016-03-01

    Full Text Available This article focuses on a number of reasons, redemption of private railways in the Russian Empire during the reign of Alexander III. Preconditions for this step. After the defeat in the Crimean War, the state began to consider two basic ways construction of railways: the expense of the treasury at the expense of private capital, including foreign ones. Attempts to organize joint capital of private foreign and domestic on the example of the main Russian Railway Company ended sadly. Foreign capital is mainly interested in speculation on the Russian stock exchange, as a result the majority of the company's shares went to the Russian capital. To support the private Russian capital the government has gone the way of the guarantee capital, in certain cases, as a joint stock or bond or one of the types of capital. When distribution concessions were not crucial economic factors, and the proximity to the elite or the corruption component. Often concession won by those who offered the lowest price, which affects the quality of railway construction in the country. As a result of the concession is not got the most professionally trained people who are almost entirely the burden shifted to the state, and profits for the most part getting any private owners. As a result, such practice is ruinous for the Treasury forced the government to buy back a significant portion of private railways on acceptable terms. As a result, initially malpractice and corruption safeguards prevent a real manifestation of self-employment initiatives

  12. The Predictive Diagnostic Value of Serial Daily Bedside Ultrasonography for Severe Dengue in Indonesian Adults

    OpenAIRE

    Meta Michels; Uun Sumardi; Quirijn de Mast; Hadi Jusuf; Mita Puspita; Intan Mauli Warma Dewi; Sylvia Sinarta; Bachti Alisjahbana; van der Ven, André J. A. M.

    2013-01-01

    BACKGROUND: Identification of dengue patients at risk for progressing to severe disease is difficult. Significant plasma leakage is a hallmark of severe dengue infection which can suddenly lead to hypovolemic shock around the time of defervescence. We hypothesized that the detection of subclinical plasma leakage may identify those at risk for severe dengue. The aim of the study was to determine the predictive diagnostic value of serial ultrasonography for severe dengue. METHODOLOGY/PRINCIPAL ...

  13. Handbook of serial communications interfaces a comprehensive compendium of serial digital input/output (I/O) standards

    CERN Document Server

    Frenzel, Louis

    2015-01-01

    This book catalogs the most popular and commonly used serial-port interfaces and provides details on the specifications and the latest standards, enabling you to select an interface for a new design or verify that an interface is working correctly. Each chapter is based on a different interface and is written in an easy to follow, standard format. With this book you will learn: The most widely used serial interfacesHow to select the best serial interface for a specific application or designThe trade-offs between data rate and distance (length or range)The operation and benefits of serial

  14. Antec starts serial production; Antec startet Serienfertigung

    Energy Technology Data Exchange (ETDEWEB)

    Iken, J.

    2001-01-12

    Thuringian producer Antec Solar has produced CdTe modules to near maturity. Serial production is envisaged for January 2001. The CdTe modules will be marketed under the name ATF (Advanced Thin Film Technology). Full production capacityis expected for mid-2002. [German] Die Fertigung von Cadmium-Tellurid-Modulen (CdTe) beim thueringischen Unternehmen Antec Solar steht vor der Serienreife. Die Nullserie wurde Anfang November gestartet und erfolgreich abgeschlossen: 'Die Produktion ist angelaufen, die ersten Module sind gefertigt'. Der Start der Serienproduktion ist fuer Anfang Januar 2001 vorgesehen. Die volle Produktionskapazitaet fuer die CdTe-Module, die Antec unter dem Namen ATF (Advanced Thin Film Technology) vermarkten will, soll Mitte naechsten Jahres erreicht werden. (orig./AKF)

  15. Huntington's disease

    DEFF Research Database (Denmark)

    Hjermind, Lena Elisabeth; Law, Ian; Jønch, Aia;

    2011-01-01

    In this open-label pilot study, the authors evaluated the effect of memantine on the distribution of brain glucose metabolism in four Huntington's disease (HD) patients as determined by serial 18-fluoro-deoxyglucose [F(18)]FDG-PET scans over a period of 3-4 months (90-129 days, with one patient...

  16. Price Index for U.S. Serial Services 1991.

    Science.gov (United States)

    Shroyer, Andrew

    1991-01-01

    Presents the annual survey of prices for U.S. serial services for 1991 which was compiled in conjunction with the Faxon Company. Comparative data for 1977-91 are included for the areas of business, humanities, law, science and technology, social science, and documents, as well as serial services from the H.W. Wilson Company. (LRW)

  17. Serials Information on CD-ROM: A Reference Perspective.

    Science.gov (United States)

    Karch, Linda S.

    1990-01-01

    Describes Ulrich's PLUS (a CD-ROM version of Ulrich's serials directories) and EBSCO's CD-ROM version of "The Serials Directory," and compares the two in terms of their use as reference tools. Areas discussed include database content, user aids, system features, search features, and a comparison of search results. Equipment requirements for both…

  18. Indexing Serialized Fiction: May the Force Be with You.

    Science.gov (United States)

    Barr, Melissa M.

    The adult novel offers indexers an unusual opportunity to create a serialized fiction index. This research paper involved designing and creating a Character Index, Thesaurus, Glossary, and Abstract (with descriptors) for 21 novels based on the "Star Wars" movies. The novels are an unusual example of serialized fiction featuring main characters,…

  19. Antisocial personality disorder, sexual sadism, malignant narcissism, and serial murder.

    Science.gov (United States)

    Geberth, V J; Turco, R N

    1997-01-01

    This paper examines the research on serial murder and its relationship to antisocial personality disorder and sexual sadism. The concept of malignant narcissism is also discussed. Case studies of serial killers are examined regarding the nature of sexual violation and crime scene behavior.

  20. Serials Positions in U. S. Academic Libraries, 1980-1988: A Survey of Position Announcements.

    Science.gov (United States)

    Mueller, Carolyn J.; Mering, Margaret V.

    1991-01-01

    Discusses serials-related functions in academic research libraries, considers the operation of a separate serials department versus integration of serials functions within a general technical services department, and describes an analysis of advertisements for serials positions that was conducted to determine the need for serials specialists and…

  1. Serial CSTR digester configuration for improving biogas production from manure

    DEFF Research Database (Denmark)

    Boe, Kanokwan; Angelidaki, Irini

    2009-01-01

    A new configuration of manure digesters for improving biogas production has been investigated in laboratory scale. A single thermophilic continuous-flow stirred tank reactor (CSTR) operated with a hydraulic retention time (HRT) of 15 days was compared to a serial CSTR configuration with volume...... distribution ratio of 80/20 and 90/10, and total HRT of 15 days. The results showed that the serial CSTR could obtain 11% higher biogas yield compared to the single CSTR. The increased biogas yield in the serial CSTR was mainly from the second reactor, which accounted for 16% and 12% of total biogas yield...... in the 90/10 and 80/20 configuration, respectively. VFA concentration in the serial CSTR was high in the first reactor but very low in the second reactor. The results from organic pulse load test showed that the second reactor in serial CSTR helped utilizing VFA produced from overloading in the first...

  2. Serial Entrepreneurship, Learning by Doing and Self-selection

    DEFF Research Database (Denmark)

    Rocha, Vera; Carneiro, Anabela; Varum, Celeste

    2015-01-01

    of the person-specific effect, using information on individuals’ past histories in paid employment, confirm that serial entrepreneurs exhibit, on average, a larger person-specific effect than non-serial business owners. Moreover, ignoring serial entrepreneurs’ self-selection overestimates learning by doing......It remains a question whether serial entrepreneurs typically perform better than their novice counterparts owing to learning by doing effects or mostly because they are a selected sample of higher-than-average ability entrepreneurs. This paper tries to unravel these two effects by exploring a novel...... empirical strategy based on continuous time duration models with selection. We use a large longitudinal matched employer-employee dataset that allows us to identify about 220,000 individuals who have left their first entrepreneurial experience, out of which over 35,000 became serial entrepreneurs. We...

  3. Design and Verification of Serial Peripheral Interface using OVM

    Directory of Open Access Journals (Sweden)

    Archana Ramesh R

    2012-11-01

    Full Text Available The main objective of the work is to design SPI Master Core using Verilog and verify the code using Open Verification Methodology. Serial Peripheral Interface (SPI is an interface that facilitates the transfer of synchronous serial data, which is engineer’s favorite for its convenience and saving system resource. SPI (Serial Peripheral Interface is a synchronous serial data link that operates in full duplex mode. It communicates in master/slave mode where the master device initiates the data frame. Multiple slave devices are allowed with individual slave select line .Serial Peripheral Interface of symmetrical structure can be synthesized using Xilinx 12.3, and then can be simulated using Questasim 10.0b. It is a popular interface used for connecting peripherals to each other and to microprocessors.

  4. Alexander von Humboldt und Carl Friedrich Gauß als Wegbereiter der neuen Disziplin Erdmagnetismus

    Directory of Open Access Journals (Sweden)

    Karin Reich

    2011-03-01

    Full Text Available AbstractThough Alexander von Humboldt was motivated for the first time to deal with earthmagnetism during his stay in Freiberg, it was in France that he really became a specialist in this respect. During most of his journeys he made earthmagnetic measurements. His collaboration with Arago was of great importance, it was in Paris that the first magnetic observatory was built. Humboldt rendered outstanding services to the investigation of earth magnetism by two major achievements: 1. He emphasized intensity measurements and 2. he put forward the law that the magnetic intensity is increasing from the magnetic equator toward the magnetic poles. At least since 1803 Carl Friedrich Gauss was interested in earthmagnetism and especially in Humboldt’s early published data. That Wilhelm Weber became professor of physics at the University of Göttingen in 1831 was a turning point for Gauss. In 1833 Göttingen was the centre of investigating earthmagnetism, a new era began which lasted only until 1843. Gauss’ main contributions were more or less theoretical, in 1832/3 he transformed Humboldt’s relative intensity measurements into absolute ones which were independent of the instrument’s needle. A new epoch began with Gauss’ publication „Allgemeine Theorie des Erdmagnetismus” (1839. The main point was the newly defined notion of „potential“. Gauss was the first to present the surface of the earth with equipotential lines. ZusammenfassungAlexander von Humboldt hatte sich bereits in Freiberg mit dem Erdmagnetismus beschäftigt; jedoch erst in Frankreich lernte er die entsprechenden Beobachtungsmethoden kennen. Auf allen seinen Reisen machte er erdmagnetische Messungen. Seine Zusammenarbeit mit Arago in Paris war besonders fruchtbar, hier wurde das erste magnetische Observatorium gebaut. Humboldt beschäftigte sich vor allem mit Intensitätsmessungen; sein wichtigster Beitrag war die Feststellung, dass die magnetische Intensität vom

  5. Consideraciones críticas sobre el modelo de Alexander V. Chayanov

    Directory of Open Access Journals (Sweden)

    Josefina Liendo

    2013-12-01

    Full Text Available Este trabajo presenta un estado de la cuestión sobre la obra del economista ruso Alexander Chayanov y su crítica. El objetivo es analizar La organización de la unidad económica campesina [1924] desde una perspectiva que contemple tanto las intenciones del autor y la arquitectura de su obra como la crítica pasada y presente de sus lectores. Comenzando por los aspectos metodológicos, se propone revisar el modelo teórico básico y su funcionamiento real. Se entiende que el aislamiento del campesinado de su medio social más amplio es el método utilizado por el autor para construir un modelo conceptual de tipo puro. Sin embargo, su obra no se reduce a este objetivo. Al tratarse de una teoría práctica, Chayanov busca probar el funcionamiento real del modelo dejando caer los supuestos iniciales para insertar a los campesinos en el marco más amplio de la economía de mercado, introduciendo elementos ausentes en la simplificación inicial: la situación de mercado, los salarios y las inversiones de capital. El análisis conduce a sostener que la operación metodológica que el autor realiza para construir la teoría socava su capacidad explicativa. Se reflexiona, finalmente, sobre las virtudes y limitaciones de la obra desde una perspectiva histórica

  6. Networking Knowledge. Considering Alexander von Humboldt’s Legacy in a New Shared Space in Education

    Directory of Open Access Journals (Sweden)

    Karin Lundberg

    2015-05-01

    Full Text Available Zusammenfassung Weltbürgerschaft und kulturelle Vielfalt sind überall gegenwärtige Konzepte im heutigen Bildungswesen. In den Vereinigten Staaten werden Lernziele und Kompetenzen geformt, um die Studenten gegenüber den vielen kulturellen Hintergründen, die in den Bildungsinstitutionen vorzutreffen sind, zu sensibilisieren.Trotzdem wird wahre Globalität, wie sie heute in den vielfältigen Diskursen und Perspektiven der Welt repräsentiert ist, immer noch in Lehrplänen und Studienarbeiten vernachlässigt. Dieser Artikel untersucht die Möglichkeiten, die sich heute im Bildungswesen durch den neuen, gemeinsam geteilten, globalen Bildungsraum anbieten, in dem die multikulturelle Studentenbevölkerung verschiedene Formen vernetzten Wissens und facettenreiche Perspektiven der Welt eine globale Plattform des Austausches bildet. Das von Alexander von Humboldt am Anfang des neunzehnten Jahrhunderts beschriebene universale Wissenschaftskonzept, beleuchtet solch einen vernetzten Ansatz an ein Wissen um die Welt, der auf heutige Bildungskonzepte und Kursdesigns einen positiven Einfluss nehmen könnte. Humboldts Schriften unterstreichen die Bedeutung der Inklusivität und des Wechselspiels zwischen Kulturen und Naturphänomenen. Indem wir Studenten mit unterschiedlichem kulturellen Hintergrundwissen dazu einladen, ihre jeweiligen Diskurse des Wissens aktiv zu repräsentieren, werden diese gegenseitig mit einander verknüpten Beziehungen des Wissens transparenter. Auf diese Weise, entsteht die Möglichkeit, heutige Lernziele mit neuen, produktiven Formen des Weltwissens zu berreichern, worin sich ein wahres Weltbürgertum, wie es sich in diesem neuen Bildungsraum des globalen Austausches hervortut, wiederspiegeln würde. Summary Global citizenship and diversity are well-represented concepts in today’s higher education. Learning outcomes and competencies are designed to sensitize students to the many cultural backgrounds of U.S. learning institutions

  7. The Impact of International Standardization on the Rules of Entry for Serials

    Science.gov (United States)

    Cannan, Judith Proctor

    1975-01-01

    The major provisions of the International Serials Data System and International Standard Bibliographic Description for Serials are presented and related to present rules of entry for serials as detailed in the Anglo-American Cataloging Rules. (Author)

  8. On the classification of diseases.

    Science.gov (United States)

    Smart, Benjamin

    2014-08-01

    Identifying the necessary and sufficient conditions for individuating and classifying diseases is a matter of great importance in the fields of law, ethics, epidemiology, and of course, medicine. In this paper, I first propose a means of achieving this goal, ensuring that no two distinct disease-types could correctly be ascribed to the same disease-token. I then posit a metaphysical ontology of diseases-that is, I give an account of what a disease is. This is essential to providing the most effective means of interfering with disease processes. Following existing work in the philosophy of medicine and epidemiology (primarily Christopher Boorse; Caroline Whitbeck; Alexander Broadbent), philosophy of biology (Joseph LaPorte; D.L. Hull), conditional analyses of causation (J.L. Mackie; David Lewis), and recent literature on dispositional essentialism (Stephen Mumford and Rani Anjum; Alexander Bird), I endorse a dispositional conception of disease. Following discussion of various conceptions of disease-identity, their relations to the clinical and pathological effects of the diseases in question, and how diseases are treated, I conclude (i) that diseases should be individuated by their causes, and (ii) that diseases are causal processes best seen as simultaneously acting sequences of mutually manifesting dispositions.

  9. Serial estimation of serum CRP levels in patients of COPD with acute exacerbation

    OpenAIRE

    Rajesh Gupta; Ramanjit Kaur; Veena Singh; Vipin Goyal; Kiran Dahiya; Anupama Gupta; Manjulata Kumawat

    2013-01-01

    Objectives By representing the C-reactive protein (CRP) levels with the dates of determining CRP, the status of disease can be known. The serial levels of CRP in patients of COPD were assessed to evaluate them as a determinant of the status of disease. Methods A total of 100 known patients of COPD were evaluated at the time of admission, discharge from the ward, follow-up at six weeks. Serum CRP was measured by quantitative turbidimetric test and was correlated with Forced expiratory volume i...

  10. Serial neuroradiological studies in focal cerebritis

    Energy Technology Data Exchange (ETDEWEB)

    Hatta, S. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Mochizuki, H. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Kuru, Y. (Dept. of Radiology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Miwa, H. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Kondo, T. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Mori, H. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Mizuno, Y. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan))

    1994-05-01

    We report serial neuroradiological studies in a patient with focal cerebritis in the head of the left caudate nucleus. On the day after the onset of symptoms, CT showed an ill-defined low density lesion. The lack of contrast enhancement appeared to be the most important finding for differentiating focal cerebritis from an encapsulated brain abscess or a tumour. MRI two days later revealed the centre of the lesion to be of slightly low intensity on T1-weighted inversion recovery (IR) images and very low intensity on T2-weighted spin echo images, which appeared to correspond to the early cerebritis stage of experimentally induced cerebritis and brain abscess. Ten days after the onset of symptoms, CT revealed a thin ring of enhancement in the head of the caudate nucleus, and a similar small ring was seen in the hypothalamus 16 days after the onset, corresponding to the late cerebritis stage. MRI nine days later revealed ill-defined high signal lesions within the involved area on the T1-weighted IR images. To our knowledge, this is the first published MRI documentation of the early cerebritis stage developing into an encapsulated brain abscess. The mechanisms underlying of these radiographic changes are discussed. (orig.)

  11. Serial neuroradiological studies in focal cerebritis

    International Nuclear Information System (INIS)

    We report serial neuroradiological studies in a patient with focal cerebritis in the head of the left caudate nucleus. On the day after the onset of symptoms, CT showed an ill-defined low density lesion. The lack of contrast enhancement appeared to be the most important finding for differentiating focal cerebritis from an encapsulated brain abscess or a tumour. MRI two days later revealed the centre of the lesion to be of slightly low intensity on T1-weighted inversion recovery (IR) images and very low intensity on T2-weighted spin echo images, which appeared to correspond to the early cerebritis stage of experimentally induced cerebritis and brain abscess. Ten days after the onset of symptoms, CT revealed a thin ring of enhancement in the head of the caudate nucleus, and a similar small ring was seen in the hypothalamus 16 days after the onset, corresponding to the late cerebritis stage. MRI nine days later revealed ill-defined high signal lesions within the involved area on the T1-weighted IR images. To our knowledge, this is the first published MRI documentation of the early cerebritis stage developing into an encapsulated brain abscess. The mechanisms underlying of these radiographic changes are discussed. (orig.)

  12. Task based synthesis of serial manipulators

    Directory of Open Access Journals (Sweden)

    Sarosh Patel

    2015-05-01

    Full Text Available Computing the optimal geometric structure of manipulators is one of the most intricate problems in contemporary robot kinematics. Robotic manipulators are designed and built to perform certain predetermined tasks. There is a very close relationship between the structure of the manipulator and its kinematic performance. It is therefore important to incorporate such task requirements during the design and synthesis of the robotic manipulators. Such task requirements and performance constraints can be specified in terms of the required end-effector positions, orientations and velocities along the task trajectory. In this work, we present a comprehensive method to develop the optimal geometric structure (DH parameters of a non-redundant six degree of freedom serial manipulator from task descriptions. In this work we define, develop and test a methodology to design optimal manipulator configurations based on task descriptions. This methodology is devised to investigate all possible manipulator configurations that can satisfy the task performance requirements under imposed joint constraints. Out of all the possible structures, the structures that can reach all the task points with the required orientations are selected. Next, these candidate structures are tested to see whether they can attain end-effector velocities in arbitrary directions within the user defined joint constraints, so that they can deliver the best kinematic performance. Additionally least power consuming configurations are also identified.

  13. Graphene-based microfluidics for serial crystallography.

    Science.gov (United States)

    Sui, Shuo; Wang, Yuxi; Kolewe, Kristopher W; Srajer, Vukica; Henning, Robert; Schiffman, Jessica D; Dimitrakopoulos, Christos; Perry, Sarah L

    2016-08-01

    Microfluidic strategies to enable the growth and subsequent serial crystallographic analysis of micro-crystals have the potential to facilitate both structural characterization and dynamic structural studies of protein targets that have been resistant to single-crystal strategies. However, adapting microfluidic crystallization platforms for micro-crystallography requires a dramatic decrease in the overall device thickness. We report a robust strategy for the straightforward incorporation of single-layer graphene into ultra-thin microfluidic devices. This architecture allows for a total material thickness of only ∼1 μm, facilitating on-chip X-ray diffraction analysis while creating a sample environment that is stable against significant water loss over several weeks. We demonstrate excellent signal-to-noise in our X-ray diffraction measurements using a 1.5 μs polychromatic X-ray exposure, and validate our approach via on-chip structure determination using hen egg white lysozyme (HEWL) as a model system. Although this work is focused on the use of graphene for protein crystallography, we anticipate that this technology should find utility in a wide range of both X-ray and other lab on a chip applications. PMID:27241728

  14. Switch for serial or parallel communication networks

    Science.gov (United States)

    Crosette, D.B.

    1994-07-19

    A communication switch apparatus and a method for use in a geographically extensive serial, parallel or hybrid communication network linking a multi-processor or parallel processing system has a very low software processing overhead in order to accommodate random burst of high density data. Associated with each processor is a communication switch. A data source and a data destination, a sensor suite or robot for example, may also be associated with a switch. The configuration of the switches in the network are coordinated through a master processor node and depends on the operational phase of the multi-processor network: data acquisition, data processing, and data exchange. The master processor node passes information on the state to be assumed by each switch to the processor node associated with the switch. The processor node then operates a series of multi-state switches internal to each communication switch. The communication switch does not parse and interpret communication protocol and message routing information. During a data acquisition phase, the communication switch couples sensors producing data to the processor node associated with the switch, to a downlink destination on the communications network, or to both. It also may couple an uplink data source to its processor node. During the data exchange phase, the switch couples its processor node or an uplink data source to a downlink destination (which may include a processor node or a robot), or couples an uplink source to its processor node and its processor node to a downlink destination. 9 figs.

  15. Serials cataloging at the turn of the century

    CERN Document Server

    Williams, James W

    2014-01-01

    An overview of the research topics and trends that have appeared over the last five years, Serials Cataloging at the Turn of the Century doesn't just tell you that there has been a lot of change--that the information environment is something of a chameleon, always beguiling and slipping out of grasp. Instead, it gives you the plain facts on the specific challenges serials catalogers have been facing and how they're meeting adversity head-on, ready to gain the advantage in the rumble with proliferating information and formats.Comprehensive, resource-packed, and easy-to-digest, Serials Catalogin

  16. Serial ATA的部分技术背景

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    仿真并行ATA模式,仿真并行ATA模式为Serial ATA控制器定义了一个等同于并行ATA的传输标准。在此模式下,Serial ATA控制器能仿真Master-Only(主通道devico 0设备)并行ATA或共享(通道)并行ATA。在Master-Only并行ATA仿真模式下,Serial ATA控制器在电脑系统中充当一个

  17. Transtornos de personalidade, psicopatia e serial killers Personality disorders, psychopathy and serial killers

    Directory of Open Access Journals (Sweden)

    Hilda C P Morana

    2006-10-01

    Full Text Available OBJETIVO: Apresentar as características básicas dos diversos transtornos específicos de personalidade, mas centrando-se no transtorno de personalidade anti-social, fazendo sua diferenciação com psicopatia. O estudo ainda se propõe a abordar a figura do serial killer, apontando a presença de aspectos psicopáticos no homicídio seriado. MÉTODO: Uma revisão bibliográfica foi feita no sentido de se abordar convergências e divergências entre diversos autores sobre um assunto tão polêmico, sobretudo quanto à viabilidade de tratamento dessa clientela forense. RESULTADOS: Enquanto o transtorno de personalidade anti-social é um diagnóstico médico, pode-se entender o termo "psicopatia", pertencente à esfera psiquiátrico-forense, como um "diagnóstico legal". Não se pode falar ainda de tratamento eficaz para os chamados "serial killers". CONCLUSÃO: Os transtornos de personalidade, especialmente o tipo anti-social, representam ainda hoje um verdadeiro desafio para a psiquiatria forense. O local mais adequado e justo para seus portadores, bem como recomendação homogênea e padronizada de tratamento são questões ainda não respondidas.OBJECTIVE: To illustrate the basic characteristics of several specific personality disorders, focusing mainly in antisocial personality disorder. The differences between antisocial personality disorder and psychopathy are highlighted. Serial killers and its psychopathic aspects are also discussed. METHOD: A bibliographic review was completed in order to outline convergences and divergences among different authors about this controversial issue, especially those concerning the possibility of treatment. RESULTS: While anti-social personality disorder is a medical diagnosis, the term "psychopathy" (which belongs to the sphere of forensic psychiatry may be understood as a "legal diagnosis". It is not still possible to identify an effective treatment for serial killers. CONCLUSION: Personality disorders

  18. Alexander von Humboldt” als Name für Forschungsschiffe vor dem Hintergrund seiner meereskundlichen Arbeiten

    Directory of Open Access Journals (Sweden)

    Gerhard Kortum

    2002-10-01

    Full Text Available Article in German, Abstract in English. A. v. Humboldt as a Name of Research VesselsA number of special purpose vessels in the world carried or carry the name of Alexander von Humboldt, who had substantial interests in oceanography. However, most of his marine texts are scattered over his major works, and he never finished his manuscript on ocean circulation. But there is a general agreement that A. v. Humboldt was one of the pioneers of marine sciences. He made his own observations on the sailing vessels he used on his expedition to the Neotropics, mainly concerning sea surface temperatures. In 2002 there was a discussion in Germany about the name of a new research vessel which is going to be commissioned in the summer of 2004. It was suggested by the science community to take the name of „Alexander von Humboldt“ again, as the new vessel is replacing a medium-sized ship with this name operated now by the Baltic Sea Research Institute in Rostock-Warnemünde. This vessel has been in service from 1970 to 1990 for the Academy of Sciences of the former German Democratic Republic. The first German research vessel „Alexander von Humboldt“ was a fishing trawler (1939. Furthermore, Peru and Mexico operate research vessels bearing Humboldt’s name. The best known „Alexander von Humboldt“ is an ocean going sailing ship of the International Sail Training Association, based in Bremen. She is engaged in educational programmes and went the South America in 1999 following Humboldt’s route. Thus, Humboldt’s marine legacy is preserved. The proposal to use the undisputed name of this great all-round scientist for the new German vessel under construction now was not successful. A high-ranking jury decided to prefer “Maria Sibylla Merian” (1647-1717, which was suggested by a young student in a nation-wide competition to find a name. As Humboldt 100 years later, she went to South America to study plants and other fields of natural history.

  19. Counseling and Psychotherapy Transcripts, Client Narratives, and Reference Works. A User’s Guide from Alexander Street Press

    OpenAIRE

    2011-01-01

    Представлено руководство по работе в базe Counseling and Psychotherapy Transcripts, Client Narratives, and Reference Works на английском языке издательства Alexander Street Press.

  20. The Grothendieck festschrift a collection of articles written in honor of the 60th birthday of Alexander Grothendieck

    CERN Document Server

    Cartier, Pierre; Katz, Nicholas; Manin, Yuri; Illusie, Luc; Laumon, Gérard; Ribet, Kenneth

    2009-01-01

    This three-volume work contains articles collected on the occasion of Alexander Grothendieck's sixtieth birthday and originally published in 1990. The articles were offered as a tribute to one of the world's greatest living mathematicians. Many of the groundbreaking contributions in these volumes contain material that is now considered foundational to the subject. Topics addressed by these top-notch contributors match the breadth of Grothendieck's own interests, including: functional analysis, algebraic geometry, algebraic topology, number theory, representation theory, K-theory, category theo

  1. Alexander Brem & Éric Viardot (eds.), Adoption of Innovation: Balancing Internal and External Stakeholders in the Marketing of Innovation

    OpenAIRE

    AYDIN, Gökhan

    2015-01-01

    Abstract. The Adoption of Innovation:Balancing Internal and External Stakeholders in the Marketing of Innovation book edited by Alexander Brem & Éric Viardot provides a contemporary look at innovation from a marketing point of view. Innovation has been a hot topic both for academicians and managers for the last twenty years may well remain an area of interest for years to come. The title of the book emphasizes basic topics that are covered in the book but it hardly represents whole covera...

  2. Area Efficient and A High Bit Rate Serial-Serial Multiplier With On-the-Fly Accumulation by Asynchronous Counters

    Directory of Open Access Journals (Sweden)

    Balakrishna Konda

    2012-11-01

    Full Text Available Traditional Serial-Serial multiplier addresses the high data sampling rate. It is effectively considered as the entire partial product matrix with n data sampling cycle for n×n multiplication function instead of 2n cycles in the conventional multipliers. This multiplication of partial products by considering two series inputs among which one is starting from LSB the other from MSB. Using this feed sequence and accumulation technique it takes only n cycle to complete the partial products. It achieves high bit sampling rate by replacing conventional full adder and highest 5:3 counters. Here asynchronous 1’s counter is presented. This counter takes critical path is limited to only an AND gate and D flip-flops. Accumulation is integral part of serial multiplier design. 1’s counter is used to count the number of ones at the end of the nth iteration in each counter produces. The implemented multipliers consist of a serial-serial data accumulator module and carry save adder that occupies less silicon area than the full carry save adder. In this paper we implemented model address for the 8bit 2’s complement implementing the Baugh-wooley algorithm and unsigned multiplication implementing the architecture for 8×8 Serial-Serial unsigned multiplication.

  3. Connecting the New World. Nets, mobility and progress in the Age of Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Moritz von Brescius

    2012-12-01

    Full Text Available Zusammenfassung Dieser Artikel untersucht das Verhältnis zwischen den revolutionären technologischen Neuerungen des 19. Jahrhunderts und dem Leben und Wirken Alexander von Humboldts (1769-1859. Dabei wird gefragt, wie Humboldt versuchte, die neuen und sprichwörtlich bahnbrechenden Kommunikations- und Transporttechnologien seiner Zeit zu nutzen, um den amerikanischen Kontinent in globale kommerzielle und kulturelle Austauschprozesse zu integrieren. Jüngere Forschungen zu Humboldts amerikanischer Expedition (1799-1804 haben behauptet, dass seine Beschreibungen Südamerikas den Kontinent für zahlreiche „transformative interventions“ (Pratt von Seiten europäischer Kapitalisten und Investoren zugänglich gemacht hätten. Diese Studien haben jedoch nicht analysiert, aus welchen Motiven heraus Humboldt diese Eingriffe in die Natur unterstützte. Darüber hinaus wurde nicht der zentralen Frage nachgegangen, welche Rolle diese Projekte in Humboldts eigener Auffassung über die Kräfte des gesellschaftlichen Fortschritts gespielt haben. Um Humboldts Unterstützung für tiefgreifende Eingriffe in die Natur Amerikas nachvollziehen zu können, analysiert dieser Artikel zunächst, welche Rolle der „Geodeterminismus“ und die Fortschrittstheorien der Aufklärung in seinem Verständnis von zivilisatorischer Entwicklung spielten. Dabei sollen solche Beispiele menschlicher Interventionen in die Natur Amerikas untersucht werden, die Humboldt selbst aktiv förderte – nicht zuletzt, da sie geeignet schienen, „natürliche“ Barrieren für gesellschaftliche Austauschprozesse zu beseitigen. Dies waren vor allem die Nutzung von Dampfschiffen, elektrischer Telegrafie, Eisenbahnen und großangelegten Kanalprojekten, deren gebündelte Effekte zu einer signifikanten Beschleunigung von Welthandel und Kommunikationsprozessen führten. Diese zeitgenössischen Innovationen sollen mit den vier Motiven „Netz“, „Mobilität“, „Fortschritt“ und

  4. Automatic registration of serial mammary gland sections

    Energy Technology Data Exchange (ETDEWEB)

    Arganda-Carreras, Ignacio; Fernandez-Gonzalez, Rodrigo; Ortiz-de-Solorzano, Carlos

    2004-04-13

    We present two new methods for automatic registration of microscope images of consecutive tissue sections. They represent two possibilities for the first step in the 3-D reconstruction of histological structures from serially sectioned tissue blocks. The goal is to accurately align the sections in order to place every relevant shape contained in each image in front of its corresponding shape in the following section before detecting the structures of interest and rendering them in 3D. This is accomplished by finding the best rigid body transformation (translation and rotation) of the image being registered by maximizing a matching function based on the image content correlation. The first method makes use of the entire image information, whereas the second one uses only the information located at specific sites, as determined by the segmentation of the most relevant tissue structures. To reduce computing time, we use a multiresolution pyramidal approach that reaches the best registration transformation in increasing resolution steps. In each step, a subsampled version of the images is used. Both methods rely on a binary image which is a thresholded version of the Sobel gradients of the image (first method) or a set of boundaries manually or automatically obtained that define important histological structures of the sections. Then distance-transform of the binary image is computed. A proximity function is then calculated between the distance image of the image being registered and that of the reference image. The transformation providing a maximum of the proximity function is then used as the starting point of the following step. This is iterated until the registration error lies below a minimum value.

  5. Alexander Mikhailovich Zakharov and his works on the venom apparatus and venoms of some poisonous snakes

    Directory of Open Access Journals (Sweden)

    Cherlin Vladimir Alexandrovich

    2013-10-01

    Full Text Available The article gives brief biographical information about a very talented herpetologist Alexander M. Zakharov, and describes the general results of his works on the structure and function of venom glands of some poisonous snakes and their venoms. In his studies, he got the results, which are fundamentally different from the conventional concept of 30s - 70s of the XX century. Unfortunately, among physicians this concept has not changed up today. At that time it was thought that the poisons of Viperidae snakes are almost completely hemotoxic, and poisons of Elapidae (cobra are almost neurotoxic. But A.M.Zaharov found out, that poisons of both types of snakes (Viperidae and Elapidae include three groups of substances: hemotoxins, neurotoxins and non-toxic component – hyaluronidase. Each of these groups of substances is produced by independent part of venom glands and has its own special effect. Neurotoxins act on the central nervous system (mainly the respiratory center, but are greatly destroyed by means of the blood antigen properties and cannot pass through the hematoencephalic barrier. Hyaluronidase , connecting with neurotoxins, has an important property – to "smuggle" neurotoxins through the hematoencephalic barrier exactly into the target organ – the respiratory center in the central nervous system. In this case, neurotoxin enters the respiratory center not through the blood and lymph vessels, but directly through the nerve channel, through synapsis. The main function of hemotoxins is not to kill the victim, but to protect neurotoxins and hyaluronidase from the destructive activity of the victim's blood. Therefore, the target of the poisons of Viperidae and Elapidae snakes is the central nervous system of victims, but Elapidae has almost no hemotoxins. That’s why their striking effect can be achieved only by a strong increase in the amount of neurotoxins and hyaluronidase. Hemotoxins of Viperidae venoms permits to reduce the amount of

  6. Fast Grasp Contact Computation for a Serial Robot

    Science.gov (United States)

    Shi, Jianying (Inventor); Hargrave, Brian (Inventor); Diftler, Myron A. (Inventor)

    2015-01-01

    A system includes a controller and a serial robot having links that are interconnected by a joint, wherein the robot can grasp a three-dimensional (3D) object in response to a commanded grasp pose. The controller receives input information, including the commanded grasp pose, a first set of information describing the kinematics of the robot, and a second set of information describing the position of the object to be grasped. The controller also calculates, in a two-dimensional (2D) plane, a set of contact points between the serial robot and a surface of the 3D object needed for the serial robot to achieve the commanded grasp pose. A required joint angle is then calculated in the 2D plane between the pair of links using the set of contact points. A control action is then executed with respect to the motion of the serial robot using the required joint angle.

  7. Evolutionary Algorithm Aided Interleaver Design for Serially Concatenated Codes

    OpenAIRE

    Maunder, R.G.; Hanzo, L

    2011-01-01

    In this paper, we propose an algorithm for designing the interleavers of Serially Concatenated Codes (SCCs), in order to increase the Minimum Hamming Distance (MHD) between the legitimate permutations of the encoded bit sequence and hence to improve the corresponding error floor. Unlike previous so-called Code Matched Interleaver (CMI) designs, our approach is capable of creating interleavers for serial concatenations of both irregular and non-linear codes, as well as achieving MHDs that are ...

  8. Wavelength Preserving Optical Serial-to-Parallel Conversion

    DEFF Research Database (Denmark)

    Galili, Michael; Palushani, Evarist; Mulvad, Hans Christian Hansen;

    2013-01-01

    We demonstrate optical wavelength preserving serial-to-parallel conversion. 9-of-16 OTDM channels are simultaneously mapped from a 160 Gbit/s signal to a 100 GHz WDM grid by wavelength preserving FWM idler generation, with BER<1E-9 performance.......We demonstrate optical wavelength preserving serial-to-parallel conversion. 9-of-16 OTDM channels are simultaneously mapped from a 160 Gbit/s signal to a 100 GHz WDM grid by wavelength preserving FWM idler generation, with BER

  9. How Do We Write about Performance in Serial Television?

    OpenAIRE

    Elliott Logan

    2015-01-01

    Television studies has produced few sustained analyses of performance in serial television. Yet film studies scholarship has shown how attending to the integration of performances with other aspects of film style is crucial to the interpretation and appreciation of expression and meaning in filmed narrative fictions. However, as a particle form of filmed serial narrative, series television raises a number of questions about performance that will not necessarily be satisfyingly addressed by th...

  10. [A serial killer as exemplified by T. R. Bundy].

    Science.gov (United States)

    Gałeska-Sliwka, Anita

    2008-01-01

    The question of serial homicides and their perpetrators poses a considerable problem of both a definitional and practical nature. T R. Bundy is the first perpetrator who was officially termed a "serial killer". Since that time, this concept has been commonly used and sometimes even overused, e.g. in reference to mass murderers. However, the definitions established for Bundy's case have been preserved and continue to be used in practice.

  11. Serial Communications Programming in Windows95 with API Functions

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper introduces the usage of these functions. It presents the technique of how to program with them to perform the serial communications between a computer and other digital devices by the serial ports in Windows95.The related sample codes of the applications of this technique written in C++ programming language are also given. This technique is applied successfully to receive the data of the radio noise from a frequency monitor.

  12. 实战Serial-ATA硬盘安装

    Institute of Scientific and Technical Information of China (English)

    阿囡

    2004-01-01

    Serial-ATA硬盘在外部结构方面与传统并行IDE硬盘有着一定的区别,因此在使用时需要格外注意。我们可以很明显地看到,Serial-ATA硬盘所采用的数据线接口以及电源接口都非常特殊(图1)。

  13. Integrated Lot Sizing in Serial Supply Chains with Production Capacities

    OpenAIRE

    Romero-Morales, Dolores; Wagelmans, Albert; Romeijn, H. Edwin; Hoesel, Stan van

    2005-01-01

    We consider a model for a serial supply chain in which production, inventory, and transportation decisions are integrated in the presence of production capacities and concave cost functions. The model we study generalizes the uncapacitated serial single-item multilevel economic lot-sizing model by adding stationary production capacities at the manufacturer level. We present algorithms with a running time that is polynomial in the planning horizon when all cost functions are concave. In additi...

  14. Serial CSTR digester configuration for improving biogas production from manure.

    Science.gov (United States)

    Boe, Kanokwan; Angelidaki, Irini

    2009-01-01

    A new configuration of manure digesters for improving biogas production has been investigated in laboratory scale. A single thermophilic continuous-flow stirred tank reactor (CSTR) operated with a hydraulic retention time (HRT) of 15 days was compared to a serial CSTR configuration with volume distribution ratio of 80/20 and 90/10, and total HRT of 15 days. The results showed that the serial CSTR could obtain 11% higher biogas yield compared to the single CSTR. The increased biogas yield in the serial CSTR was mainly from the second reactor, which accounted for 16% and 12% of total biogas yield in the 90/10 and 80/20 configuration, respectively. VFA concentration in the serial CSTR was high in the first reactor but very low in the second reactor. The results from organic pulse load test showed that the second reactor in serial CSTR helped utilizing VFA produced from overloading in the first reactor, which improved the effluent quality and conversion efficiency of the serial CSTR.

  15. How Do We Write about Performance in Serial Television?

    Directory of Open Access Journals (Sweden)

    Elliott Logan

    2015-05-01

    Full Text Available Television studies has produced few sustained analyses of performance in serial television. Yet film studies scholarship has shown how attending to the integration of performances with other aspects of film style is crucial to the interpretation and appreciation of expression and meaning in filmed narrative fictions. However, as a particle form of filmed serial narrative, series television raises a number of questions about performance that will not necessarily be satisfyingly addressed by the direct adoption and application of approaches to writing about performance that have been honed in regard to film. How, then, do we write about performance in television serials in ways that recognise and accommodate the form’s relationship to film, while at the same time appropriately acknowledging and responding to long-form television’s serial status? To examine the difficulties and opportunities of approaching performance in serial television this way, the article conducts close readings of various pieces of television studies writing on performance, by scholars such as Jason Mittell, Sue Turnbull, George Toles, and Steven Peacock. Their work brings into view film and television’s points of common relation, and the distinctive challenges, achievements, and rewards of appreciating the best television serials, and the performances in them.

  16. Three more semantic serial position functions and a SIMPLE explanation.

    Science.gov (United States)

    Kelley, Matthew R; Neath, Ian; Surprenant, Aimée M

    2013-05-01

    There are innumerable demonstrations of serial position functions-with characteristic primacy and recency effects-in episodic tasks, but there are only a handful of such demonstrations in semantic memory tasks, and those demonstrations have used only two types of stimuli. Here, we provide three more examples of serial position functions when recalling from semantic memory. Participants were asked to reconstruct the order of (1) two cartoon theme song lyrics, (2) the seven Harry Potter books, and (3) two sets of movies, and all three demonstrations yielded conventional-looking serial position functions with primacy and recency effects. The data were well-fit by SIMPLE, a local distinctiveness model of memory that was originally designed to account for serial position effects in short- and long-term episodic memory. According to SIMPLE, serial position functions in both episodic and semantic memory tasks arise from the same type of processing: Items that are more separated from their close neighbors in psychological space at the time of recall will be better remembered. We argue that currently available evidence suggests that serial position functions observed when recalling items that are presumably in semantic memory arise because of the same processes as those observed when recalling items that are presumably in episodic memory.

  17. Alexander Pope and Heroic Couplet%亚历山大·蒲伯与英雄双韵体

    Institute of Scientific and Technical Information of China (English)

    何津

    2014-01-01

    Alexander Pope is one of the greatest poetsin British Enlightenment,best known for his satirical verse and for his trans⁃lation of Homer. Heroic couplet, two successive rhyming lines of iambic pentameter, is a popular form of English poetryin the 18th century.After a long process of development, it is Alexander Pope who carries heroic couplet to perfection.%亚历山大·蒲伯是英国启蒙时期最伟大的诗人之一,因其讽刺诗篇和翻译荷马史诗而闻名。英雄双韵体指连续两行压韵的五音步抑扬格,是18世纪英国流行的诗歌形式。经过漫长的发展过程,亚历山大·蒲伯将英雄双韵体推向了完美。

  18. Mielekkäät liikkeet instrumenttiopintoihin : Alexander-tekniikan opettajan ja muusikon näkökulma soitinopintojen alkuvaiheeseen

    OpenAIRE

    Markula, Helena

    2015-01-01

    Opinnäytetyöni päämääränä on auttaa soitinopintojaan aloittelevien lasten opettajia löytämään sellaisia opetustapoja, jotka ohjaavat lapsia yhdistämään musiikin tekemiseen luonnollisen hyvän toimivuuden säilymisen. Kerron omista lähtökohdistani muusikkona ja Alexander-tekniikan opettajana sekä Alexander-tekniikasta ja sen aikaisemmasta soveltamisesta lasten ja musiikin opetukseen. Pohdin lasten lähtötilannetta ennen soitinopiskelujen aloittamista sekä kerron hyvän koordinaation perusteist...

  19. Reorganising the Local Government at the End of the 18th and the Beginning of the 19th Centuries: Comparative Analysis of the Policies of Paul I and Alexander I

    Directory of Open Access Journals (Sweden)

    Jurij V. Tot

    2013-12-01

    Full Text Available The article examines the reorganisation of the local government undertaken by Paul I and Alexander I at the beginning of their reigns. In utilising legal acts, minutes of sessions of the State Council as well the historiography of the problem, the author comes to a conclusion regarding the identity of the policies of Paul I and Alexander I.

  20. The predictive diagnostic value of serial daily bedside ultrasonography for severe dengue in Indonesian adults.

    Directory of Open Access Journals (Sweden)

    Meta Michels

    Full Text Available BACKGROUND: Identification of dengue patients at risk for progressing to severe disease is difficult. Significant plasma leakage is a hallmark of severe dengue infection which can suddenly lead to hypovolemic shock around the time of defervescence. We hypothesized that the detection of subclinical plasma leakage may identify those at risk for severe dengue. The aim of the study was to determine the predictive diagnostic value of serial ultrasonography for severe dengue. METHODOLOGY/PRINCIPAL FINDINGS: Daily bedside ultrasounds were performed with a handheld ultrasound device in a prospective cohort of adult Indonesians with dengue. Timing, localization and relation to dengue severity of the ultrasonography findings were determined, as well as the relation with serial hematocrit and albumin values. The severity of dengue was retrospectively determined by WHO 2009 criteria. A total of 66 patients with proven dengue infection were included in the study of whom 11 developed severe dengue. Presence of subclinical plasma leakage at enrollment had a positive predictive value of 35% and a negative predictive value of 90% for severe dengue. At enrollment, 55% of severe dengue cases already had subclinical plasma leakage, which increased to 91% during the subsequent days. Gallbladder wall edema was more pronounced in severe than in non-severe dengue patients and often preceded ascites/pleural effusion. Serial hematocrit and albumin measurements failed to identify plasma leakage and patients at risk for severe dengue. CONCLUSIONS/SIGNIFICANCE: Serial ultrasonography, in contrast to existing markers such as hematocrit, may better identify patients at risk for development of severe dengue. Patients with evidence of subclinical plasma leakage and/or an edematous gallbladder wall by ultrasonography merit intensive monitoring for development of complications.

  1. Serial intralesional injections of infliximab in small bowel Crohn’s strictures are feasible and might lower inflammation

    DEFF Research Database (Denmark)

    Hendel, Jakob; Karstensen, John Gásdal; Vilmann, Peter

    2014-01-01

    BACKGROUND: Crohn's disease can cause strictures throughout the gastrointestinal tract. Endoscopic balloon dilatation is a well-established treatment, but recurrence is seen in up to three out of four cases. Infliximab is playing an increasingly important role in the modern systemic treatment...... is feasible. OBJECTIVE: We wanted to assess whether serial intralesional injection of infliximab in small bowel strictures is feasible and reduces local inflammation. METHODS: We included six patients with Crohn's disease and inflammatory small bowel strictures. They were treated with endoscopic serial...... balloon dilatation. Subsequent to each dilatation, 40 mg infliximab was injected submucosally. A modified simplified endoscopic score for Crohn's disease was used for the involved area before the initial treatment and at the final follow-up after six months. Complications and development of symptoms were...

  2. Alexander von Humboldt brachte Guano nach Europa - mit ungeahnten globalen Folgen

    Directory of Open Access Journals (Sweden)

    Bärbel Rott

    2016-05-01

    Full Text Available Zusammenfassung Die vorliegende Abhandlung beschäftigt sich mit einem bisher wenig beachteten Aspekt von Humboldts Amerikanischer Reise (1799─1804. Während seine Studien der Pflanzen- und Tierwelt bis heute große Aufmerksamkeit genießen, wird Humboldts Beitrag zu der Entwicklung der modernen Landwirtschaft wenig beachtet. Während seines Aufenthalts in Lima erhielt er Proben von Guano, Vogelmist von den Chincha-Inseln vor der peruanischen Küste. Einige Proben, die er von dieser Reise zurückbrachte, wurden von Wissenschaftlern in Frankreich und Deutschland untersucht. Die Analysenergebnisse zeigten außerordentlich hohe Gehalte an Pflanzennährstoffen, insbesondere Stickstoff und Phosphor. In den folgenden Jahrzehnten wurde Guano zu einem bedeutsamen Düngemittel und Auslöser eines Booms in Europa und Peru. Die Auswirkungen dieser Entwicklung sind bis heute sichtbar und werden hier unter besonderer Beachtung von Phosphor beschrieben. Abstract One aspect of Humboldt’s travel to South America (1799─1804 received little attention. The fascination of his studies of the South American flora and fauna is unbroken to the present day. Yet Humboldt’s contribution to modern agriculture remains almost unnoticed. During his stay in Lima Humboldt received samples of guano, a mixture of bird droppings from the Chincha Islands off the Peruvian coast, which he took to Europe and had analyzed by the most famous chemists in France and Germany. The results showed outstanding fertilizing effects, in particular due to the high content of nitrogen and phosphorus. The ensuing boom starting from the 1840s influenced agriculture in Europe and the economy of Peru seriously. Some aspects of this historical development may give an idea of the ensuing change not only in agriculture. Résumé Il y a un aspect du voyage de Alexander von Humboldt en Amérique du Sud (1799─1804 qui jusqu’à présent a été peu considéré. Ses études de la flore at le da

  3. Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography

    Directory of Open Access Journals (Sweden)

    Pardo Moira

    2007-01-01

    Full Text Available Abstract Cancer therapy has shown terrific progress leading to important reduction of morbidity and mortality of several kinds of cancer. The therapeutic management of oncologic patients includes combinations of drugs, radiation therapy and surgery. Many of these therapies produce adverse cardiovascular complications which may negatively affect both the quality of life and the prognosis. For several years the most common noninvasive method of monitoring cardiotoxicity has been represented by radionuclide ventriculography while other tests as effort EKG and stress myocardial perfusion imaging may detect ischemic complications, and 24-hour Holter monitoring unmask suspected arrhythmias. Also biomarkers such as troponine I and T and B-type natriuretic peptide may be useful for early detection of cardiotoxicity. Today, the widely used non-invasive method of monitoring cardiotoxicity of cancer therapy is, however, represented by Doppler-echocardiography which allows to identify the main forms of cardiac complications of cancer therapy: left ventricular (systolic and diastolic dysfunction, valve heart disease, pericarditis and pericardial effusion, carotid artery lesions. Advanced ultrasound tools, as Integrated Backscatter and Tissue Doppler, but also simple ultrasound detection of "lung comet" on the anterior and lateral chest can be helpful for early, subclinical diagnosis of cardiac involvement. Serial Doppler echocardiographic evaluation has to be encouraged in the oncologic patients, before, during and even late after therapy completion. This is crucial when using anthracyclines, which have early but, most importantly, late, cumulative cardiac toxicity. The echocardiographic monitoring appears even indispensable after radiation therapy, whose detrimental effects may appear several years after the end of irradiation.

  4. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: The Alexander the First collection of the Lausanne Museum

    NARCIS (Netherlands)

    Minina, E.L.

    2004-01-01

    Study of written sources in archives sometimes allows to restore the history of collections. A good example is the Alexander the First collection. In 1819, de la Harpe had sent an Etruscan vase to Alexander I as a gift, and had received a collection of Russian minerals in return. Alexander's collect

  5. Hardware Implementation of Serially Concatenated PPM Decoder

    Science.gov (United States)

    Moision, Bruce; Hamkins, Jon; Barsoum, Maged; Cheng, Michael; Nakashima, Michael

    2009-01-01

    A prototype decoder for a serially concatenated pulse position modulation (SCPPM) code has been implemented in a field-programmable gate array (FPGA). At the time of this reporting, this is the first known hardware SCPPM decoder. The SCPPM coding scheme, conceived for free-space optical communications with both deep-space and terrestrial applications in mind, is an improvement of several dB over the conventional Reed-Solomon PPM scheme. The design of the FPGA SCPPM decoder is based on a turbo decoding algorithm that requires relatively low computational complexity while delivering error-rate performance within approximately 1 dB of channel capacity. The SCPPM encoder consists of an outer convolutional encoder, an interleaver, an accumulator, and an inner modulation encoder (more precisely, a mapping of bits to PPM symbols). Each code is describable by a trellis (a finite directed graph). The SCPPM decoder consists of an inner soft-in-soft-out (SISO) module, a de-interleaver, an outer SISO module, and an interleaver connected in a loop (see figure). Each SISO module applies the Bahl-Cocke-Jelinek-Raviv (BCJR) algorithm to compute a-posteriori bit log-likelihood ratios (LLRs) from apriori LLRs by traversing the code trellis in forward and backward directions. The SISO modules iteratively refine the LLRs by passing the estimates between one another much like the working of a turbine engine. Extrinsic information (the difference between the a-posteriori and a-priori LLRs) is exchanged rather than the a-posteriori LLRs to minimize undesired feedback. All computations are performed in the logarithmic domain, wherein multiplications are translated into additions, thereby reducing complexity and sensitivity to fixed-point implementation roundoff errors. To lower the required memory for storing channel likelihood data and the amounts of data transfer between the decoder and the receiver, one can discard the majority of channel likelihoods, using only the remainder in

  6. Orientation angle rotatability of planar serial n-link manipulators

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This paper presents a new method of analyzing the orientation angle rotatability of a planar serial n-link manipulator by examining the rotatability of its virtual equivalent mechanism.Workspace orientation boundary region decomposition is proposed based on the polynomial discriminant derived from a serial three-link manipulator.Orientation angle workspace indicates a set of angle ranges by which the end-effector can reach with certain orientation for every point in the reachable position workspace.By introducing a virtual equivalent mechanism,the open-chain kinematic problem is converted into a close-chain mechanism,and the Grashof-type condition is used to examine the rotatability of the end-effector link.The reachable position workspace can be divided into several Grashof intervals and non-Grashof intervals based on the extreme positions and singular configurations of a manipulator.The derived equations in this paper can be used to calculate the variation rule of the orientation angle workspace of any given planar serial n-link manipulator on the basis of its link parameters.The orientation angle rotatability of a seven-link serial manipulator is solved by the proposed method and graphical representations of the orientation angle workspaces are mapped onto a three-dimensional coordinate system.The theoretical approach has practical significance for the design of a highly dexterous serial n-link manipulator with proposed link relations.

  7. Genetic programming and serial processing for time series classification.

    Science.gov (United States)

    Alfaro-Cid, Eva; Sharman, Ken; Esparcia-Alcázar, Anna I

    2014-01-01

    This work describes an approach devised by the authors for time series classification. In our approach genetic programming is used in combination with a serial processing of data, where the last output is the result of the classification. The use of genetic programming for classification, although still a field where more research in needed, is not new. However, the application of genetic programming to classification tasks is normally done by considering the input data as a feature vector. That is, to the best of our knowledge, there are not examples in the genetic programming literature of approaches where the time series data are processed serially and the last output is considered as the classification result. The serial processing approach presented here fills a gap in the existing literature. This approach was tested in three different problems. Two of them are real world problems whose data were gathered for online or conference competitions. As there are published results of these two problems this gives us the chance to compare the performance of our approach against top performing methods. The serial processing of data in combination with genetic programming obtained competitive results in both competitions, showing its potential for solving time series classification problems. The main advantage of our serial processing approach is that it can easily handle very large datasets.

  8. The relationship between serial sexual murder and autoerotic asphyxiation.

    Science.gov (United States)

    Myers, Wade C; Bukhanovskiy, Alexandr; Justen, Elle; Morton, Robert J; Tilley, John; Adams, Kenneth; Vandagriff, Virgil L; Hazelwood, Robert R

    2008-04-01

    This case series documents and examines the association between autoerotic asphyxiation, sadomasochism, and serial sexual murderers. Autoerotic asphyxiation, along with other paraphilias found in this population, is reviewed. Five cases of serial sexual killers who engaged in autoerotic asphyxiation were identified worldwide: four from the United States and one from Russia. Case reports for each are provided. All (100%) were found to have sexual sadism in addition to autoerotic asphyxiation. Furthermore, two (40%) had bondage fetishism, and two (40%) had transvestic fetishism, consistent with these paraphilias co-occurring in those with autoerotic asphyxiation. Overall the group averaged 4.0 lifetime paraphilias. Some possible relationships were observed between the offenders' paraphilic orientation and their modus operandi, e.g., all of these serial killers strangled victims-suggesting an association between their sadistic and asphyxiative paraphilic interests. The overlap of seemingly polar opposite paraphilias in this sample--sexual sadism and autoerotic asphyxiation--is explored from a historical and clinical perspective. Multiple commonalities shared between these five offenders and serial sexual murderers in general are addressed. A primary limitation of this study is its small sample size and empirical basis; the results may not be generalizable beyond the sample. The findings from this study support the supposition that crime scene behaviors often reflect paraphilic disturbances in those who commit serial sexual homicides. PMID:17980531

  9. The relationship between serial sexual murder and autoerotic asphyxiation.

    Science.gov (United States)

    Myers, Wade C; Bukhanovskiy, Alexandr; Justen, Elle; Morton, Robert J; Tilley, John; Adams, Kenneth; Vandagriff, Virgil L; Hazelwood, Robert R

    2008-04-01

    This case series documents and examines the association between autoerotic asphyxiation, sadomasochism, and serial sexual murderers. Autoerotic asphyxiation, along with other paraphilias found in this population, is reviewed. Five cases of serial sexual killers who engaged in autoerotic asphyxiation were identified worldwide: four from the United States and one from Russia. Case reports for each are provided. All (100%) were found to have sexual sadism in addition to autoerotic asphyxiation. Furthermore, two (40%) had bondage fetishism, and two (40%) had transvestic fetishism, consistent with these paraphilias co-occurring in those with autoerotic asphyxiation. Overall the group averaged 4.0 lifetime paraphilias. Some possible relationships were observed between the offenders' paraphilic orientation and their modus operandi, e.g., all of these serial killers strangled victims-suggesting an association between their sadistic and asphyxiative paraphilic interests. The overlap of seemingly polar opposite paraphilias in this sample--sexual sadism and autoerotic asphyxiation--is explored from a historical and clinical perspective. Multiple commonalities shared between these five offenders and serial sexual murderers in general are addressed. A primary limitation of this study is its small sample size and empirical basis; the results may not be generalizable beyond the sample. The findings from this study support the supposition that crime scene behaviors often reflect paraphilic disturbances in those who commit serial sexual homicides.

  10. Alexander Graham Bell's Patent for the Telephone and Thomas Edison's Patent for the Electric Lamp. The Constitution Community: The Development of the Industrial United States (1870-1900).

    Science.gov (United States)

    Schur, Joan Brodsky

    In 1876 Americans held a Centennial Exhibition in Philadelphia (Pennsylvania) to celebrate the nation's birth 100 years earlier. Machinery Hall drew the most admiration and wonder. Alexander Graham Bell exhibited the first telephone, and Thomas Alva Edison presented the automatic telegraph, one of more than 1,000 inventions he would patent in his…

  11. Towards time-resolved serial crystallography in a microfluidic device.

    Science.gov (United States)

    Pawate, Ashtamurthy S; Šrajer, Vukica; Schieferstein, Jeremy; Guha, Sudipto; Henning, Robert; Kosheleva, Irina; Schmidt, Marius; Ren, Zhong; Kenis, Paul J A; Perry, Sarah L

    2015-07-01

    Serial methods for crystallography have the potential to enable dynamic structural studies of protein targets that have been resistant to single-crystal strategies. The use of serial data-collection strategies can circumvent challenges associated with radiation damage and repeated reaction initiation. This work utilizes a microfluidic crystallization platform for the serial time-resolved Laue diffraction analysis of macroscopic crystals of photoactive yellow protein (PYP). Reaction initiation was achieved via pulsed laser illumination, and the resultant electron-density difference maps clearly depict the expected pR(1)/pR(E46Q) and pR(2)/pR(CW) states at 10 µs and the pB1 intermediate at 1 ms. The strategies presented here have tremendous potential for extension to chemical triggering methods for reaction initiation and for extension to dynamic, multivariable analyses.

  12. Violent cultural factors and serial homicide by males.

    Science.gov (United States)

    DeFronzo, James; Prochnow, Jane

    2004-02-01

    Explaining the phenomenon of male serial homicide has usually been approached from a psychiatric perspective. However, recent integrative theory suggests that cultural factors may play a role in shaping the psychology of young males with particular psychiatric and possibly neurological vulnerabilities in such ways as to facilitate converting the motivation to kill into actual behavior. Present results indicated that 34-45% of the interstate variation in rates of serial killer activity could be accounted for by three dimensions of local culture. Higher rates of male serial killer activity were associated with a local state culture supportive of game hunting and military training and a local culture supportive of punitive violence. The findings must be viewed with caution since societal variables are complex and the results are based on correlations which cannot be causally interpreted without more direct evidence of validity.

  13. A combination strategy for tracking the serial criminal

    Science.gov (United States)

    He, Chuan; Zhang, Yuan-Biao; Wan, Jiadi; Yu, Wenjing

    2010-08-01

    We build a Geographic Profiling Model to generate the criminal's geographical profile, by combining two complementary strategies: the Spatial Distribution Strategy and the Probability Distance Strategy. In the first strategy, we designate the mean of all the known crime sites as the anchor point, and build a Standard Deviational Ellipse Model, considering the effect of landscape. In the second strategy, we take many factors such as the buffer zone and distance decay theory into consideration and calculate the probability of the offender's residence in a certain area by using the Bayesian Theorem and the Rossmo Algorithm. Then, we combine the result of two strategies and get three search areas suit different conditions of the police to track the serial criminal. Apply the model to the English serial killer Peter Sutcliffe's case, the calculation result shows that the model can effectively be used to track serial criminal.

  14. Hallar e inventar a un público. Nuevos proyectos editoriales acerca de la obra de Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2008-10-01

    Full Text Available Article in español, abstracts in englisch, español and german.In Latin America, Alexander von Humboldt was and is known as one of the most famous historic and literary figures; in his own country, though, the acquaintance with his texts has until the 80s been reduced to groups of specialized scholars. Yet, for a couple of years, a growing interest in the works of Humboldt can be noticed, based on numerous new editions, which have been published since. Among others, these are the new edition of the Relation historique (1991, the editions of the „Humboldt Project“ (2004-2006 as part of the „Andere Bibliothek“, as well as current projects on German editions concerning Asie Centrale and the Examen critique.

  15. The evolution of ultrahigh carbon steels - from the Great Pyramids, to Alexander the Great, to Y2K

    Energy Technology Data Exchange (ETDEWEB)

    Wadsworth, J

    1999-10-01

    Hypereutectoid steels containing between about 1 and 2.1 wt%C, and now known as ultrahigh carbon steels (UHCS), have both a rich history (dating back to the time of Alexander the Great, i.e. {approximately} 300 BC) and an interesting, recent, technological period of development (from 1975 to the present). The connections between the modern UHCS and their ancient counterparts, and in particular Damascus steels, have received considerable attention. In addition to monolithic products, UHCS have also been used in both ancient and modern times in laminated composites. In the present paper, a summary of the modern development of UHCS and UHCS-containing laminates is given, and parallels are drawn with ancient materials. Also, ancient laminated composites containing other steels are described; controversial issues and a possible solution related to the age of such a laminate found in the Great Pyramid of Gizeh are discussed.

  16. Alexander von Humboldt y la génesis de la geografía física moderna

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Vitte

    2010-10-01

    Full Text Available Article in Spanish. AbstractThis article discusses the genesis of modern physical geography since the formation of the concepts of nature, space and morphology in the writings of Alexander von Humboldt. Influenced by the reflections of Kant in the “Critique of Judgment”, the writings of Goethe and Schelling, Humboldt has developed a new interpretation and representation of nature in the earth’s surface that turned the concept of space out to be crucial to the explanation of the phenomena of nature. A complex starting point of influences as such aesthetics or self developed instrumentals has structured modern Physical Geography through a principle of connection between artistic and scientific invention in the geographic concept of landscape.

  17. The appearance of the artist to the people: the creativity, personality and malady of Alexander Ivanov (1806-58).

    Science.gov (United States)

    Lerner, Vladimir; Witztum, Eliezer

    2005-02-01

    Alexander Ivanov was an outstanding Russian painter who lived in the middle of the nineteenth century, during the romantic period. He did not accept romanticism but instead tried to create his own original style, an ambitious combination of spiritual profundity and a manner of execution unparalleled in Western European art. Ivanov's intention and style are best reflected in his major work The Appearance of Christ to the People, a picture on which he worked for over 20 years. He painted more than 400 sketches of the picture while attempting to bring his masterpiece to perfection. At the end of his life Ivanov became disillusioned, renounced his strong religious conviction and became suspicious. This study examines the influence of his background, life story and personality on the creative process. From a diagnostic perspective, Ivanov's personality featured obsessive, narcissistic and schizoid traits. In his final years he suffered from a delusional disorder. PMID:15682233

  18. Jade aus Amerika und weitere Grünsteinobjekte von Alexander von Humboldt aus dem Berliner Mineralienkabinett

    Directory of Open Access Journals (Sweden)

    Renate Nöller

    2002-04-01

    Full Text Available Article in German, Abstracts in English, Spanish and German.Alexander von Humboldt sent samples of minerals from America not only for scientific or economic purposes. We also find carved pieces made out of green stone material known as Jade, that has been culturally very important in Mesoamerica. In Europe these green stone objects have been treated differently. The Jade-Celt and the Sun-Disc - known as “Humboldt-Axt” and “Humboldt-Scheibe” - both lost during the second world war, had gained great interest, whereas a small head-pendant - made out of Jade has been totally forgotten. The samples reflect the understanding of their worth in distinct cultural contexts.

  19. On the American expedition of Alexander von Humboldt (1769-1859: connection with nature, nomadic impulse and self-realization

    Directory of Open Access Journals (Sweden)

    Jordi García Farrero

    2015-06-01

    Full Text Available In this article, the author approaches the figure of Alexander von Humboldt (1769-1859 basically for two reasons. First, he is one of the leading naturalists and geographers of Romanticism, as demonstrated by the following scientific contributions: the organic unity between man and nature, and the vision of nature as a realm of freedom; secondly, his biographical trajectory is quite inspiring from a pedagogical perspective, concerning the scientific expedition he conducted along with the French botanist Aimé Bonpland (1773-1858 through the Americas. Thus, this paper intends to carry out a pedagogical reading of the said journey, divided into the three stages proposed by the same German scientist (preparation, travel and preparation of the work, in order to highlight a number of concepts (nature, nomadism and self-training as part of different pedagogical worldviews that have occurred throughout the history of education. With this background, this proposed itinerary concludes by emphasizing that one of its possible pedagogical drifts can be an educational practice as well-known as field trips. It is, therefore, a study that has been carried out through the hermeneutics of the main texts of Humboldt and others from natural science and, of course, of pedagogy. How to reference this article García Farrero, J. (2015. Sobre la expedición americana de Alexander von Humboldt (1769-1859: vinculación con la naturaleza, impulso nómada y realización de uno mismo. Espacio, Tiempo y Educación, 2(2, 313-333. doi: http://dx.doi.org/10.14516/ete.2015.002.002.015

  20. THE SERIAL MODEL IN LIQUID FLUIDIZATION AND ITS LIMITATIONS

    Institute of Scientific and Technical Information of China (English)

    R. Escudié; N. Epstein; H. T. Bi; J. R. Grace

    2006-01-01

    The serial model of Epstein et al. (1981) is demonstrated to predict successfully the overall voidage of the mixed layer of incompletely segregated binary and ternary mixtures of liquid-fluidized solids that differ only in shape. Some speculations are then offered on the conditions for the success and failure of this model. Finally, methods proposed in the literature for estimating the deviations from the serial model for a binary-solids bed, which manifest themselves as a bed contraction, are discussed, with emphasis on packing models.

  1. The stand-alone test and decreasing serial cost sharing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Thorlund-Petersen, Lars

    2000-01-01

    The rule of decreasing serial cost sharing defined in de Frutos [1] over the class of concave cost functions may violate the important stand-alone test. Sufficient conditions for the test to be satisfied are given, in terms of individual rationality as well as coalitional stability. These conditi......The rule of decreasing serial cost sharing defined in de Frutos [1] over the class of concave cost functions may violate the important stand-alone test. Sufficient conditions for the test to be satisfied are given, in terms of individual rationality as well as coalitional stability...

  2. IT-based Value Creation in Serial Acquisitions

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Yetton, Philip

    2013-01-01

    serial acquirers realize IT-based value, we integrate and model the findings on individual acquisitions from the extant literature, and extend that model to explain the effects of sequential acquisitions in a growth-by-acquisition strategy. This extended model, drawing on the Resource-Based Theory......The extant research on post-acquisition IT integration analyzes how acquirers realize IT-based value in individual acquisitions. However, serial acquirers make 60% of acquisitions. These acquisitions are not isolated events, but are components in growth-by-acquisition programs. To explain how...

  3. Serial murder in America: case studies of seven offenders.

    Science.gov (United States)

    Beasley, James O

    2004-01-01

    This article summarizes and compares information on seven interviewed serial killers in an ongoing project designed to study similarities and differences among these individuals. The aim of this article is to increase our collective knowledge of the dynamics of serial murder by examining the perpetrators' backgrounds, as well as the unique ways in which they view themselves and the world around them. Although qualitative interview research alone is not sufficient to fully understand such behavior, it is useful in many ways. Some of the information discussed based on the seven offenders interviewed is compared with broader epidemiological studies, and the strengths and limitations of each type of research are discussed.

  4. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Nakane, Takanori [The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Song, Changyong [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); POSTECH, Pohang 790-784 (Korea, Republic of); Suzuki, Mamoru [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871 (Japan); Nango, Eriko; Kobayashi, Jun [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Masuda, Tetsuya [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan); Inoue, Shigeyuki [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Mizohata, Eiichi [Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan); Nakatsu, Toru [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Tanaka, Tomoyuki; Tanaka, Rie [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Shimamura, Tatsuro [Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi [Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Hatsui, Takaki; Yabashi, Makina [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Nureki, Osamu [The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Iwata, So [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Sugahara, Michihiro, E-mail: msuga@spring8.or.jp [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan)

    2015-11-27

    Sulfur SAD phasing facilitates the structure determination of diverse native proteins using femtosecond X-rays from free-electron lasers via serial femtosecond crystallography. Serial femtosecond crystallography (SFX) allows structures to be determined with minimal radiation damage. However, phasing native crystals in SFX is not very common. Here, the structure determination of native lysozyme from single-wavelength anomalous diffraction (SAD) by utilizing the anomalous signal of sulfur and chlorine at a wavelength of 1.77 Å is successfully demonstrated. This sulfur SAD method can be applied to a wide range of proteins, which will improve the determination of native crystal structures.

  5. Neurodegeneration in D-bifunctional protein deficiency: diagnostic clues and natural history using serial magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Aneal [University of Calgary, Department of Medical Genetics and Pediatrics, Alberta Children' s Hospital, Calgary, AB (Canada); Wei, Xing-Chang [University of Calgary, Department of Radiology, Alberta Children' s Hospital, Calgary, AB (Canada); Snyder, Floyd F. [Alberta Children' s Hospital, Biochemical Genetics Laboratory, Calgary, AB (Canada); Mah, Jean K. [University of Calgary, Division of Neurology, Department of Pediatrics, Calgary, AB (Canada); Waterham, Hans; Wanders, Ronald J.A. [University of Amsterdam, Academic Medical Center, Lab Genetic Metabolic Diseases, Amsterdam (Netherlands)

    2010-12-15

    We report serial neurodegenerative changes on neuroimaging in a rare peroxisomal disease called D-bifunctional protein deficiency. The pattern of posterior to anterior demyelination with white matter disease resembles X-linked adrenoleukodystrophy. We feel this case is important to (1) highlight that D-bifunctional protein deficiency should be considered in cases where the neuroimaging resembles X-linked adrenoleukodystrophy, (2) to show different stages of progression to help identify this disease using neuroimaging in children, and (3) to show that neuroimaging suggesting a leukodystrophy can warrant peroxisomal beta-oxidation studies in skin fibroblasts even when plasma very long chain fatty acids are normal. (orig.)

  6. Whole-pattern fitting technique in serial femtosecond nanocrystallography

    Science.gov (United States)

    Dilanian, Ruben A.; Williams, Sophie R.; Martin, Andrew V.; Streltsov, Victor A.; Quiney, Harry M.

    2016-01-01

    Serial femtosecond X-ray crystallography (SFX) has created new opportunities in the field of structural analysis of protein nanocrystals. The intensity and timescale characteristics of the X-ray free-electron laser sources used in SFX experiments necessitate the analysis of a large collection of individual crystals of variable shape and quality to ultimately solve a single, average crystal structure. Ensembles of crystals are commonly encountered in powder diffraction, but serial crystallography is different because each crystal is measured individually and can be oriented via indexing and merged into a three-dimensional data set, as is done for conventional crystallography data. In this way, serial femtosecond crystallography data lie in between conventional crystallography data and powder diffraction data, sharing features of both. The extremely small sizes of nanocrystals, as well as the possible imperfections of their crystallite structure, significantly affect the diffraction pattern and raise the question of how best to extract accurate structure-factor moduli from serial crystallography data. Here it is demonstrated that whole-pattern fitting techniques established for one-dimensional powder diffraction analysis can be feasibly extended to higher dimensions for the analysis of merged SFX diffraction data. It is shown that for very small crystals, whole-pattern fitting methods are more accurate than Monte Carlo integration methods that are currently used. PMID:27006776

  7. Ultra-high-speed serial optical communications: Enabling technologies

    DEFF Research Database (Denmark)

    Oxenløwe, Leif Katsuo; Galili, Michael; Mulvad, Hans Christian Hansen;

    2008-01-01

    This paper will present recently identified and demonstrated key technologies for ultra-high-speed serial communications. Certain key components such as stabilised highly non-linear fibre switches, periodically poled Lithium Niobate devices and semiconductor optical amplifiers will be described w...

  8. Asymmetrical learning between a tactile and visual serial RT task

    NARCIS (Netherlands)

    Abrahamse, Elger L.; Lubbe, van der Rob H.J.; Verwey, Willem B.

    2007-01-01

    According to many researchers, implicit learning in the serial reaction-time task is predominantly motor based and therefore should be independent of stimulus modality. Previous research on the task, however, has focused almost completely on the visual domain. Here we investigated sequence learning

  9. Kiondo Bag Boutique: A Serial Case for Introductory Financial Accounting

    Science.gov (United States)

    Siriwardane, Harshini P.

    2014-01-01

    Kiondo Bag Boutique is a hypothetical serial case involving a start-up retail business. The case evolves from an ambitious business idea to a successful business. Through the evolving business, the importance of accounting information is highlighted. Different iterations are used to illustrate the role of accounting in serving and managing…

  10. 'American Psycho': a double portrait of serial yuppie Patrick Bateman

    NARCIS (Netherlands)

    J. Kooijman; T. Laine

    2003-01-01

    Kooijman and Laine analyze Mary Harron's "American Psycho," a 2000 film adaptation of the 1980s satirical novel by Bret Easton Ellis in which Patrick Bateman, a narcissistic Wall Street young urban professional ("yuppie"), assumes an alternate identity as a serial killer. The authors examine the dou

  11. Context dependent learning in the serial RT task

    NARCIS (Netherlands)

    Abrahamse, Elger L.; Verwey, Willem B.

    2007-01-01

    This study investigated the development of contextual dependencies for sequential perceptual-motor learning on static features in the learning environment. In three experiments we assessed the eVect of manipulating task irrelevant static context features in a serial reaction-time task. Experiment 1

  12. Development of parallel/serial program analyzing tool

    International Nuclear Information System (INIS)

    Japan Atomic Energy Research Institute has been developing 'KMtool', a parallel/serial program analyzing tool, in order to promote the parallelization of the science and engineering computation program. KMtool analyzes the performance of program written by FORTRAN77 and MPI, and it reduces the effort for parallelization. This paper describes development purpose, design, utilization and evaluation of KMtool. (author)

  13. Whole-pattern fitting technique in serial femtosecond nanocrystallography

    Directory of Open Access Journals (Sweden)

    Ruben A. Dilanian

    2016-03-01

    Full Text Available Serial femtosecond X-ray crystallography (SFX has created new opportunities in the field of structural analysis of protein nanocrystals. The intensity and timescale characteristics of the X-ray free-electron laser sources used in SFX experiments necessitate the analysis of a large collection of individual crystals of variable shape and quality to ultimately solve a single, average crystal structure. Ensembles of crystals are commonly encountered in powder diffraction, but serial crystallography is different because each crystal is measured individually and can be oriented via indexing and merged into a three-dimensional data set, as is done for conventional crystallography data. In this way, serial femtosecond crystallography data lie in between conventional crystallography data and powder diffraction data, sharing features of both. The extremely small sizes of nanocrystals, as well as the possible imperfections of their crystallite structure, significantly affect the diffraction pattern and raise the question of how best to extract accurate structure-factor moduli from serial crystallography data. Here it is demonstrated that whole-pattern fitting techniques established for one-dimensional powder diffraction analysis can be feasibly extended to higher dimensions for the analysis of merged SFX diffraction data. It is shown that for very small crystals, whole-pattern fitting methods are more accurate than Monte Carlo integration methods that are currently used.

  14. Serial takeovers, large shareholders, and CEOs’ equity-based compensation

    NARCIS (Netherlands)

    Pikulina, E.S.; Renneboog, L.D.R.; Hill, J.; Thomas, R.

    2015-01-01

    In this chapter we investigate how the structure of a CEO’s compensation package – and especially his bonus and equity-based compensation (EBC) – influences his M & A decisions. We find that a CEO with a higher proportion of EBC is more likely to initiate (serial) acquisitions. Likewise, a CEO who r

  15. Asymmetric binding in serial memory for verbal and spatial information

    NARCIS (Netherlands)

    Guerard, Katherine; Morey, Candice C.; Lagace, Sebastien; Tremblay, Sebastien

    2013-01-01

    As the number of studies showing that items can be retained as bound representations in memory increases, researchers are beginning to investigate how the different features are bound together. In the present study, we examined the relative importances of the verbal and spatial features in serial me

  16. Dyslexia: The Effects of Visual Memory and Serial Recall.

    Science.gov (United States)

    McIntyre, Thomas C.

    Research on the role of visual memory and serial recall in dyslexia is reviewed. Findings touch on feature theory, which proposes that information is held in the form of "features," and that students for example learn to discriminate letters by marking certain identifiable aspects. Other studies are described which focus on speed of processing…

  17. Bit Serial Architecture for Variable Block Size Motion Estimation

    Directory of Open Access Journals (Sweden)

    Krishna Kaveri Devarinti

    2013-06-01

    Full Text Available H.264/AVC is the latest video coding standard adopting variable block size, quarter-pixel accuracy and motion vector prediction and multi-reference frames for motion estimations. These new features result in higher computation requirements than that for previous coding standards.The computational complexity of motion estimation is about 60% in the H.264/AVC encoder. In this paper most significant bit (MSB first arithmetic based bit serial Variable Block Size Motion Estimation (VBSME hardware architecture is proposed. MSB first bit serial architecture main feature is, its early termination SAD computation compared to normal bit serial architectures. With this early termination technique, number computations are reduced drastically. Hence power consumption is also less compared to parallel architectures. An efficient bit serial processing element is proposed and developed 2D architecture for processing of 4x4 block in parallel .Inter connect structure is developed in such way that data reusability is achieved between PEs. Two types of adder trees are employed for variable block size SAD calculation with less number of adders. The proposed architecture can generate up to 41 motion vectors (MVs for each macroblock. The inter connection complexity between PEs reduced drastically compared to parallel architectures. The architecture supports processing of SDTV (640x480 with 30fps at 172.8 MHz for search range [+8, -7]. We could reduce 14% of computations by using early termination technique.

  18. Serial Mechanisms in Lexical Access: The Rank Hypothesis

    Science.gov (United States)

    Murray, W. S.; Forster, K. I.

    2004-01-01

    There is general agreement that the effect of frequency on lexical access time is roughly logarithmic, although little attention has been given to the reason for this. The authors argue that models of lexical access that incorporate a frequency-ordered serial comparison or verification procedure provide an account of this effect and predict that…

  19. Child serial murder-psychodynamics: closely watched shadows.

    Science.gov (United States)

    Turco, R

    2001-01-01

    There is a malignant transformation in object relations resulting in an identification with an omnipotent and cruel object resulting in an identity transformation. If the tension, desperation, and dissociation increase, serial murder becomes spree murder. The presence of pathological narcissism and psychopathic tendencies are of diagnostic significance in understanding the murderer's personality functioning and motivation to kill. Meloy (1988) considered the degree of sadism and aggression combined with narcissistic qualities to reflect the "malignancy" of the psychopathic disturbance where gratification (of aggression) occurs in the service of narcissistic functioning--that is, cruelty toward others in the form of a triumphant victory over a rejecting object. Meloy also believes that dissociation is ubiquitious in the psychopath. The initial murder of the serial murderer may reflect a "new identity." The pathological object-relations of narcissism and the malignant narcissism are important diagnostic indicators in the personality functioning of serial killers and the occurrence of these phenomena is a significant factor in the formation of the personalities of serial killers, their inner motivations, and their pattern of commission.

  20. Serial Killers: Academic Libraries Respond to Soaring Costs.

    Science.gov (United States)

    McCarthy, Paul

    1994-01-01

    Discusses ways in which academic libraries are responding to rising costs of serials. Topics addressed include pricing by publishers; the effect of journal cancellations on research activities; interlibrary loans and document delivery services; coordinated cancelling; electronic journals; and experiences at the University of Arizona. (LRW)

  1. Experiment und Wissensvermittlung. Alexander von Humboldts Darstellungsmethoden in seinen Versuchen über die gereizte Muskel- und Nervenfaser

    Directory of Open Access Journals (Sweden)

    Alexander Stöger

    2016-11-01

    Full Text Available Zusammenfassung Alexander von Humboldt hat sich in jungen Jahren mit galvanischen Experimenten beschäftigt und die Resultate in einem umfassenden, zweibändigen Werk publiziert. Dabei zeigte er nicht nur, dass er als Experimentator und Teil der wissenschaftlichen Gemeinschaft fähig war, sich mit einem so neuen und komplexen Phänomen zu beschäftigen. Es lässt sich auch erkennen, dass er bereits in dieser frühen Schrift versuchte, das umfangreiche Wissen dem Leser zugänglich zu machen. Der Artikel betrachtet Humboldts Galvanismusschrift Versuche über die gereizte Muskel- und Nervenfaser (1797–1798 und untersucht einige Elemente wie Anhänge und Schreibstil, die Humboldt nutzte, um die umfangreichen Informationen zu ordnen und dem Leser so neben den Big Data seiner Erkenntnisse auch passende Suchfunktionen zur Verfügung zu stellen, die eine gezielte Nutzung überhaupt ermöglichen.  Abstract In the early stages of his scientific career, Alexander von Humboldt took an interest in experiments in galvanism. He publicised the results in a two-volume work under the title Versuche über die gereizte Muskel- und Nervenfaser (Experiments on the Stimulated Muscle and Nerve Fibre in 1797 and 1798. In this treatise, he presented himself as competent experimenter and member of the scientific community, but also demonstrated that he was capable of researching new and complex phenomena. These volumes also provide insight into his early attempts to facilitate the readers’ access to the extensive information he had compiled. This article analyses some aspects of Humboldt’s efforts to arrange his vast numbers of observations and theories, for example by means of appendices and narrative style, which he used not only to present the resulting big data collected during his research, but also to make it possible for the reader to organise and utilise this data.   Resumen A temprana edad Alexander von Humboldt se dedicó a galvanismo. En 1797 y 1798

  2. DISEASES

    DEFF Research Database (Denmark)

    Pletscher-Frankild, Sune; Pallejà, Albert; Tsafou, Kalliopi;

    2015-01-01

    Text mining is a flexible technology that can be applied to numerous different tasks in biology and medicine. We present a system for extracting disease-gene associations from biomedical abstracts. The system consists of a highly efficient dictionary-based tagger for named entity recognition...... of human genes and diseases, which we combine with a scoring scheme that takes into account co-occurrences both within and between sentences. We show that this approach is able to extract half of all manually curated associations with a false positive rate of only 0.16%. Nonetheless, text mining should...... not stand alone, but be combined with other types of evidence. For this reason, we have developed the DISEASES resource, which integrates the results from text mining with manually curated disease-gene associations, cancer mutation data, and genome-wide association studies from existing databases...

  3. SAIISA: a project for semi-automatic assignment of ISSN codes to Italian serials

    OpenAIRE

    Verniti, Vincenzo; Mangiaracina, Silvana; Cancedda, Flavia

    2011-01-01

    SAIISA is a project designed with the aim of assigning ISSN codes to Italian serials included in the Italian Serials Catalogue, ACNP, using semiautomatic procedures developed at the ISSN International Centre (IC). The ACNP Catalogue contains about 34,000 Italian serials lacking ISSN codes (about 65% of all Italian serials). This lack of information causes several problems in the case of automatic uploads of the records from library catalogues and also reduces the international visibility of I...

  4. Evaluating return on investment in a school based health promotion and prevention program: the investment multiplier for the Stephanie Alexander Kitchen Garden National Program.

    Science.gov (United States)

    Eckermann, Simon; Dawber, James; Yeatman, Heather; Quinsey, Karen; Morris, Darcy

    2014-08-01

    Successful health promotion and disease prevention strategies in complex community settings such as primary schools rely on acceptance and ownership across community networks. Assessing multiplier impacts from investment on related community activity over time are suggested as key alongside evidence of program health effects on targeted groups of individuals in gauging community network engagement and ownership, dynamic impacts, and program long term success and return on investment. An Australian primary school based health promotion and prevention strategy, the Stephanie Alexander Kitchen Garden National Program (SAKGNP), which has been providing garden and kitchen classes for year 3-6 students since 2008, was evaluated between 2011 and 2012. Returns on Australian Federal Government investment for school infrastructure grants up to $60,000 are assessed up to and beyond a two year mutual obligation period with: (i) Impacts on student lifestyle behaviours, food choices and eating habits surveyed across students (n = 491 versus 260) and parents (n = 300 versus 234) in 28 SAKGNP and 14 matched schools, controlling for school and parent level confounders and triangulated with SAKGNP pre-post analysis; (ii) Multiplier impacts of investment on related school and wider community activity up to two years; and (iii) Evidence of continuation and program evolution in schools observed beyond two years. SAKGNP schools showed improved student food choices (p = 0.024) and kitchen lifestyle behaviour (p = 0.019) domains compared to controls and in pre-post analysis where 20.0% (58/290) reported eating fruit and vegetables more often and 18.6% (54/290) preparing food at home more often. No significant differences were found in case control analysis for eating habits or garden lifestyle behaviour domains, although 32.3% of children helped more in the garden (91/278) and 15.6% (45/289) ate meals together more often in pre-post analysis. The multiplier impact on total

  5. „Warum ich nicht Diorit-Trachyt sagen soll.“ – Ein geologischer Brief Gustav Roses an Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Konstantin Treuber

    2014-08-01

    Full Text Available Zusammenfassung Gustav Rose (1798-1873 begleitete Alexander von Humboldt auf seiner Russlandreise und stand bis zu Humboldts Tod persönlich und postalisch zum ihm in Kontakt. Die Edition des vorliegenden Briefs zielt darauf ab, die Bedeutung der Person Gustav Rose in ihrer Beziehung zu Alexander von Humboldt und ihrem Einfluss auf den mineralogisch-geologischen Teil des Kosmos zu beleuchten und dem Leser dieses interessante historische Dokument zugänglich zu machen. Abstract Gustav Rose (1798-1873 accompanied Humboldt on his journey to Russia. He kept in touch with Humboldt after this expedition until Humboldt died in 1859. The edition of the letter at hand aims at highlighting Rose’s relation to Humboldt and how he influenced the geological and mineralogical part of the Kosmos. It shall also make this impressive historical document accessible to readers by providing illustrating annotations.

  6. Shakespeare à l’écran : Makibefo d’Alexander Abela, un exemple extrême d’appropriation culturelle Alexander Abela’s Makibefo: an Example of Radical Cultural Appropriation on Screen

    Directory of Open Access Journals (Sweden)

    Anne-Marie Costantini-Cornède

    2009-06-01

    Full Text Available Alexander Abela’s Makibefo (1999 shot in Madagascar and played by non-professional actors. The use of the Antandroy people or “an ancient tribe” who had never even seen a film before, is an example of cultural appropriation or a “transcultural” approach to the play, a complex process of rewriting which consists in a narrative and aesthetic remoulding of the play adapted. By transposing the play Macbeth to an unusual context, a poor fishermen’s village lost at the other end of the world, the filmmaker means to enhance its mythic and universal dimension. He resorts to various narrative and aesthetic strategies such as plot displacements, character suppressions or dialogue simplifications as well as ample and systematic use of cinematic rhetoric (camera movements, framing and angle shot effects or light contrasts, which helps create a filmic mode. The process is paradoxical, as it is not so much meant to deconstruct the play as to reconstruct its essential meaning in a novel, powerful and visionary way, thus offering an alternative reading of the play.

  7. Thirteen Steps to Avoiding Bad Luck in a Serials Cancellation Project.

    Science.gov (United States)

    Metz, Paul

    1992-01-01

    Rampant inflation in serials' pricing is forcing many academic libraries to initiate serials cancellation projects. If libraries plan carefully and involve faculty throughout the process, serials can be canceled without excessive damage to the collection or to the library's relationship with the rest of the college. (six references) (LAE)

  8. 77 FR 66920 - Registration of Claims to Copyright: Group Registration of Serial Issues Filed Electronically

    Science.gov (United States)

    2012-11-08

    ... of Claims to Copyright, 72 FR 36883 (July 6, 2007). When this electronic system was implemented, it... certain serial publications. 55 FR 50556 (December 7, 1990). Under these regulations, issues of serials... Copyright Office 37 CFR Part 202 Registration of Claims to Copyright: Group Registration of Serial...

  9. Entre a batuta e o tubo de ensaio: a carreira admirável de Alexandre Borodin Between baton and test tube: the admirable career of Alexander Borodin

    OpenAIRE

    Carlos A. L. Filgueiras

    2002-01-01

    Alexander Borodin (1833-1887) is a singularity in the history of science. Whereas other scientists may have kept lifelong interests in some artistic field, he was unique in pursuing with great success two parallel careers in both chemistry and music, managing to excell in both to the end of his life. Although he considered himself primarily a chemist, present-day appreciation of his powerful music has greatly surpassed interest for his chemistry. This article treats the life and the unusual d...

  10. Acute Cholecystitis Detected by Serial Emergency Department Focused Right Upper Quadrant Ultrasound

    Directory of Open Access Journals (Sweden)

    David Bosch

    2016-06-01

    Full Text Available Acute cholecystitis is a common etiology of acute right upper quadrant pain in patients presenting to the emergency department (ED. The use of ED-focused right upper quadrant ultrasound (RUQ US is becoming more widely utilized to evaluate abdominal pain thought to be hepatobiliary in nature. We describe a case series of two patients with acute cholecystitis detected by serial ED-focused RUQ US. Case 1: A woman presented to the ED with epigastric pain of acute onset. She was initially found to have a mild leukocytosis and cholelithiasis detected by ED-focused RUQ US. Seventy-five minutes later, the patient had a repeat bedside ultrasound by the same sonographer that showed visual evidence of acute cholecystitis that was later confirmed by surgical pathology. She was treated operatively. Case 2: A man with known cholelithiasis presents to the ED with acute-onset RUQ pain. Initial RUQ ultrasound performed by the Department of Radiology (University of Colorado Hospital was equivocal, showing cholelithiasis with a mildly thickened wall and no pericholecystic fluid. A repeat ED-focused RUQ ultrasound 5 hours later showed increased wall thickness and pericholecystic fluid. The patient was subsequently taken for same-day cholecystectomy. This case series demonstrates the dynamic and progressive nature of acute cholecystitis detected by ED-focused RUQ US. It also highlights how serial bedside ultrasonography can reduce harm, appropriately triage patients with hepatobiliary disease and lead to reductions in overall morbidity.

  11. Serial Section Registration of Axonal Confocal Microscopy Datasets for Long-Range Neural Circuit Reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Hogrebe, Luke; Paiva, Antonio R.; Jurrus, Elizabeth R.; Christensen, Cameron; Bridge, Michael; Dai, Li; Pfeiffer, Rebecca; Hof, Patrick; Roysam, Badrinath; Korenberg, Julie; Tasdizen, Tolga

    2012-06-15

    In the context of long-range digital neural circuit reconstruction, this paper investigates an approach for registering axons across histological serial sections. Tracing distinctly labeled axons over large distances allows neuroscientists to study very explicit relationships between the brain's complex interconnects and, for example, diseases or aberrant development. Large scale histological analysis requires, however, that the tissue be cut into sections. In immunohistochemical studies thin sections are easily distorted due to the cutting, preparation, and slide mounting processes. In this work we target the registration of thin serial sections containing axons. Sections are first traced to extract axon centerlines, and these traces are used to define registration landmarks where they intersect section boundaries. The trace data also provides distinguishing information regarding an axon's size and orientation within a section. We propose the use of these features when pairing axons across sections in addition to utilizing the spatial relationships amongst the landmarks. The global rotation and translation of an unregistered section are accounted for using a random sample consensus (RANSAC) based technique. An iterative nonrigid refinement process using B-spline warping is then used to reconnect axons and produce the sought after connectivity information.

  12. [Some criminological and psychopathologic reflexions about serial crimes].

    Science.gov (United States)

    Romi, Juan Carlos

    2011-01-01

    This article reviews the concept of serial crime, including murder as well as any action for the purpose of inflicting bodily harm upon any person. It characterizes three types of multi-murderers: serial killers, mass murderers, and spree killers. These offenders often have a specific (ritual) behavior that is idiosyncratic and repeated on each crime, which allows the psychological profiling of the murderer. Examples, a psychopathological background, and a description of both their criminal behavior and dynamics are provided for each of these criminals. They are further classified according to their different motivations: psychotic, prophetic or enlightened, pleasure, secondary or pecuniary profits, power or control. Finally, the author shares his personal experience over 20 years in the assessment of sexual offenders. PMID:22091451

  13. Freeing the Serial Mechanism Designer from Inverse Kinematic Solvability Constraints

    Directory of Open Access Journals (Sweden)

    Diana C. W. Friedman

    2010-01-01

    Full Text Available This paper presents a fast numerical solution for the inverse kinematics of a serial manipulator. The method is implemented on the C-arm, a manipulator designed for use in robotic surgery. The inverse kinematics solution provides all possible solutions for any six degree-of-freedom serial manipulator, assuming that the forward kinematics are known and that it is possible to solve for the remaining joint angles if one joint angle’s value is known. With a fast numerical method and the current levels of computing power, designing a manipulator with closed-form inverse kinematics is no longer necessary. When designing the C-arm, we therefore chose to weigh other factors, such as actuator size and patient safety, more heavily than the ability to find a closed-form inverse kinematics solution.

  14. Low-Stroke Actuation for a Serial Robot

    Science.gov (United States)

    Gao, Dalong (Inventor); Ihrke, Chris A. (Inventor)

    2014-01-01

    A serial robot includes a base, first and second segments, a proximal joint joining the base to the first segment, and a distal joint. The distal joint that joins the segments is serially arranged and distal with respect to the proximal joint. The robot includes first and second actuators. A first tendon extends from the first actuator to the proximal joint and is selectively moveable via the first actuator. A second tendon extends from the second actuator to the distal joint and is selectively moveable via the second actuator. The robot includes a transmission having at least one gear element which assists rotation of the distal joint when an input force is applied to the proximal and/or distal joints by the first and/or second actuators. A robotic hand having the above robot is also disclosed, as is a robotic system having a torso, arm, and the above-described hand.

  15. Dental identification in serial homicides: the Green River Murders.

    Science.gov (United States)

    Rothwell, B R; Haglund, W; Morton, T H

    1989-09-01

    At least 40 young women have died at the hands of a serial killer in what has been called the Green River Murders. Because most of the victims' remains were severely decomposed with partial or complete skeletonization and little or no personal effects were recovered, forensic odontologic methods played a key role in their identifications. Although numerous methods were used to accumulate leads to the identities of the badly decomposed skeletonized remains, leads generated through traditional investigative methods established the identities in most cases. Of 40 victims, 36 have now been identified, mainly by means of dental evidence. This article details the challenges presented by serial homicides and the key role of forensic odontologic methods in the Green River Murders investigation.

  16. Jacob--the case of a serial killer.

    Science.gov (United States)

    Kallian, M; Bar-el, Y C; Durst, R; Witztum, E

    1996-01-01

    This paper describes a rare forensic psychiatric syndrome which has been the subject of massive publicity in the last decade. Despite the widespread interest, the psychodynamic process whereby a person becomes a serial murderer remains largely unknown. "Jacob" was convicted of a series of murders that he carried out over a decade. The case material is based on the psychiatric reports that were presented to the court and the many articles published in the local press at the time. Despite the limitations imposed by the material, the available information on "Jacob" bears some similarity to the phenomenological and psychodynamic models described in the literature. An attempt is made to understand the transformation of a person into a serial killer considering the life events, psychopathology and stressors that lead to the emergence from the world of imagination and fantasy of a potential murderer to the deeds that comprise the syndrome.

  17. Serial Nuclear Transfer of Goat-Rabbit Interspecies Reconstructed Embryos

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhi-guo; CHENG Li-zi; ZHANG Xiao-rong; LIU Ya; JING Ren-tao; WANG Cun-li; ZHAO Huan; LI Bin; CAO Chen-chong; LI Dong-wei

    2005-01-01

    The experiments of serial nuclear transfer were conducted between Boer goat and rabbit. The enucleated oocytes of rabbit were used as recipients while the blastomeres of goat morula was used as nuclear donor. The reconstructed embryos developing to morula were used as donor for serial cloning. As a result, two generations of reconstructed embryos were obtained, including 58 first generation reconstructed embryos and 14 second generation reconstructed embryos. The fusion rates were 79.5 and 70%, respectively. and there was no significant difference between them (P>0.05). The cleavage rates were 75.9 and 28.6% respectively with significant difference (P<0.01). No blastocyst was obtained from the second generation reconstructed embryos while 13.8% of first generation reconstructed embryos developed to blastocyst.

  18. [Some criminological and psychopathologic reflexions about serial crimes].

    Science.gov (United States)

    Romi, Juan Carlos

    2011-01-01

    This article reviews the concept of serial crime, including murder as well as any action for the purpose of inflicting bodily harm upon any person. It characterizes three types of multi-murderers: serial killers, mass murderers, and spree killers. These offenders often have a specific (ritual) behavior that is idiosyncratic and repeated on each crime, which allows the psychological profiling of the murderer. Examples, a psychopathological background, and a description of both their criminal behavior and dynamics are provided for each of these criminals. They are further classified according to their different motivations: psychotic, prophetic or enlightened, pleasure, secondary or pecuniary profits, power or control. Finally, the author shares his personal experience over 20 years in the assessment of sexual offenders.

  19. Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.

    Science.gov (United States)

    Weierstall, Uwe; James, Daniel; Wang, Chong; White, Thomas A; Wang, Dingjie; Liu, Wei; Spence, John C H; Bruce Doak, R; Nelson, Garrett; Fromme, Petra; Fromme, Raimund; Grotjohann, Ingo; Kupitz, Christopher; Zatsepin, Nadia A; Liu, Haiguang; Basu, Shibom; Wacker, Daniel; Han, Gye Won; Katritch, Vsevolod; Boutet, Sébastien; Messerschmidt, Marc; Williams, Garth J; Koglin, Jason E; Marvin Seibert, M; Klinker, Markus; Gati, Cornelius; Shoeman, Robert L; Barty, Anton; Chapman, Henry N; Kirian, Richard A; Beyerlein, Kenneth R; Stevens, Raymond C; Li, Dianfan; Shah, Syed T A; Howe, Nicole; Caffrey, Martin; Cherezov, Vadim

    2014-01-01

    Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography. Data collected from sub-10-μm-sized crystals produced with less than 0.5 mg of purified protein yield structural insights regarding cyclopamine binding to the Smoothened receptor.

  20. A STUDY ON ASYNCHRONOUS SERIAL COMMUNICATON BETWEEN COMPONENTS IN AUTOMOBILES

    OpenAIRE

    ŞAHİN, Yaşar Güneri

    2010-01-01

    ABSTRACTIn connection with the developments in the automobile sector, the number of in-automobile components, the amount of cable used for providing in-automobile communication between these components and costs are increased gradually. In this study, a method is presented in which asynchronous serial connection is used for decreasing the initial and maintenance costs by means of decreasing the amount of cables used in middle and lower class automobiles. The electronic circuits required to es...

  1. Topological analysis of singularity loci for serial and parallel manipulators

    OpenAIRE

    Paganelli, Davide

    2008-01-01

    Singularities of robot manipulators have been intensely studied in the last decades by researchers of many fields. Serial singularities produce some local loss of dexterity of the manipulator, therefore it might be desirable to search for singularityfree trajectories in the jointspace. On the other hand, parallel singularities are very dangerous for parallel manipulators, for they may provoke the local loss of platform control, and jeopardize the structural integrity of links o...

  2. Serialized participatory culture: the digital transformation of youth audiences

    OpenAIRE

    Ganito, Carla; Burnay, Catarina Duff; Ferreira, Cátia

    2012-01-01

    Digital technologies are transforming audiences and media practices. In a context of serialization this paper wants to make the case for television series as much of the attention from the industry and the academy is drawn by music and cinema neglecting the effects on television viewing. Lawrence Lessig has proposed “remix” as one of the main outcomes of social and cultural practices enabled by new technologies that allow for easy production and sharing. Henry Jenkins talks of a "convergence ...

  3. Serial Analysis of Gene Expression: Applications in Human Studies

    OpenAIRE

    Renu Tuteja; Narendra Tuteja

    2004-01-01

    Serial analysis of gene expression (SAGE) is a powerful tool, which provides quantitative and comprehensive expression profile of genes in a given cell population. It works by isolating short fragments of genetic information from the expressed genes that are present in the cell being studied. These short sequences, called SAGE tags, are linked together for efficient sequencing. The frequency of each SAGE tag in the cloned multimers directly reflects the transcript abundance. Therefore, SAGE r...

  4. building a comprehensive serials decision database at Virginia Tech

    OpenAIRE

    Metz, P.; Cosgriff, J.

    2000-01-01

    Although for many years academic libraries have relied on data on cost, library use, or citations to inform collection development decisions respecting serials, they have not fully exploited the possibilities for compiling numerous measures into comprehensive databases for decision support. The authors discuss the procedures used and the advantages realized from an effort to build such a resource at Virginia Polytechnic Institute and State University (Virginia Tech), where the available data ...

  5. An efficient ternary serial adder based on carbon nanotube FETs

    OpenAIRE

    Mohammad Hossein Moaiyeri; Molood Nasiri; Nooshin Khastoo

    2016-01-01

    This paper presents an efficient ternary serial adder for nanotechnology employing negative, positive and standard ternary logics. Multiple-valued logic results in chips with more density, less complexity and high-bandwidth data transfer. The unique properties of CNTFETs such as the capability of adapting the desired threshold voltage by changing the diameters of the nanotubes and same carrier mobility for the n-type and p-type devices play an important role in designing this circuit. The pro...

  6. Mexican Serials: Titles, Contents and Readers of Treasures to Tap

    OpenAIRE

    Lau, Jesús

    2001-01-01

    Mexican journals are usually ignored at local and foreign universities despite the fact that they convey the most updated academic and scientific information generated by national researchers and writers. Libraries and readers have difficulty in accessing Mexican journals, because local serials are normally out of the mainstream of journal indexing and full-text databases from the industrialized world. The barriers for local journals are many, among them the language, limited marketing, and...

  7. Occupational therapy articles in serial publications: an analysis of sources.

    OpenAIRE

    Reed, K L

    1988-01-01

    This study was designed to locate and document serial literature on occupational therapy published since 1900. Emphasis is placed on finding articles on occupational therapy or by occupational therapists from sources other than those normally associated with the professional journals. Multiple sources were used including print indexes, online databases, occupational therapy bibliographies, and tables of contents or yearly indexes. Almost 7,000 articles were identified, not including those pub...

  8. Oil-free hyaluronic acid matrix for serial femtosecond crystallography

    Science.gov (United States)

    Sugahara, Michihiro; Song, Changyong; Suzuki, Mamoru; Masuda, Tetsuya; Inoue, Shigeyuki; Nakane, Takanori; Yumoto, Fumiaki; Nango, Eriko; Tanaka, Rie; Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi; Hatsui, Takaki; Yabashi, Makina; Nureki, Osamu; Numata, Keiji; Iwata, So

    2016-04-01

    The grease matrix was originally introduced as a microcrystal-carrier for serial femtosecond crystallography and has been expanded to applications for various types of proteins, including membrane proteins. However, the grease-based matrix has limited application for oil-sensitive proteins. Here we introduce a grease-free, water-based hyaluronic acid matrix. Applications for proteinase K and lysozyme proteins were able to produce electron density maps at 2.3-Å resolution.

  9. Which serial killers commit suicide? An exploratory study.

    Science.gov (United States)

    Lester, David; White, John

    2012-11-30

    In a sample of 483 serial killers, 6.2% were documented to have committed suicide. Those who committed suicide were found to come from more dysfunctional homes characterized by more psychiatric disturbance in the parents. The sexual acts involved in the murders by the suicides seemed to be more deviant in some aspects, such as committing more bizarre sexual acts or more often taping the murder.

  10. THE TRADITIONS OF ERMOLAY-ERAZMUS'S "THE TALE OF PETER AND FEVRONIA" IN ALEXANDER PUSHKIN'S NOVEL "THE CAPTAIN'S DAUGHTER"

    Directory of Open Access Journals (Sweden)

    Natalya Gennadievna Komar

    2013-11-01

    Full Text Available This article raises the question of the Old Russian sources of Alexander Pushkin’s novel The Captain’s Daughter and presents an attempt to identify the traditions of Ermolay-Erazmus’s The Tale of Peter and Fevronia in it. The main purpose of the research was to identify the parallelism between Pushkin’s novel and The Tale at the imaginative, narrative and thematic levels. Therefore, it was based on application of the comparative method. The main characters of both the books are compared in succession: Prince Peter and Peter Grinyov first, and then Fevronia and Masha Mironova. The results of the analysis lead to the conclusion that the male images reflect the spiritual evolution from being self-willed to obtaining Christian humility, and the key moment of the characters’ spiritual evolution is the meeting with wise virgins, etc. As far as the female images are concerned, the key parallel between them is the praise of their wisdom at the end of both stories. Thus, the material of the research enables us to speak about the traditions of The Tale of Peter and Fevronia being preserved in Pushkin’s last novel.

  11. Growing community: the impact of the Stephanie Alexander Kitchen Garden Program on the social and learning environment in primary schools.

    Science.gov (United States)

    Block, Karen; Gibbs, Lisa; Staiger, Petra K; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

    2012-08-01

    This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has a positive impact on student engagement, social connections, and confidence within and beyond the school gates. Primary evidence for the research question came from qualitative data collected from students, parents, teachers, volunteers, school principals, and specialist staff through interviews, focus groups, and participant observations. This was supported by analyses of quantitative data on child quality of life, cooperative behaviors, teacher perceptions of the school environment, and school-level educational outcome and absenteeism data. Results showed that some of the program attributes valued most highly by study participants included increased student engagement and confidence, opportunities for experiential and integrated learning, teamwork, building social skills, and connections and links between schools and their communities. In this analysis, quantitative findings failed to support findings from the primary analysis. Limitations as well as benefits of a mixed-methods approach to evaluation of complex community interventions are discussed.

  12. Two Exceptional Witnesses of Latin American Independence: The Prussian Explorer Alexander Von Humboldt and The Virginian Politician Thomas Jefferson

    Directory of Open Access Journals (Sweden)

    Sandra Rebok

    2014-01-01

    Full Text Available Este artículo analiza las respectivas posturas de Alexander von Humboldt y Thomas Jefferson en relación con la independencia de los territorios hispanoamericanos y el modo en que estas se hallaban condicionadas por sus propias experiencias: Humboldt, como observador de la situación americana justo antes del comienzo de los movimientos independentistas; y Jefferson, como actor importante en la independencia de los EE.UU. y la posterior creación de una nueva sociedad. Asimismo, no se pueden estudiar sus respectivas posiciones hacia los movimientos independentistas en la América española, desvinculadas de sus conclusiones respecto a la Revolución francesa y sus consecuencias. El trabajo muestra de qué manera los dos personajes comentaron estos sucesos en la correspondencia que mantuvieron entre sí. Finalmente, también se evalúan, a través de estos famosos representantes del llamado Nuevo Mundo y el Viejo Mundo, las diferencias y similitudes en la manera de reaccionar ante estos eventos políticos y sociales desde el punto de vista europeo, en comparación con la mirada desde Norteamérica.

  13. Voltage balancing strategies for serial connection of microbial fuel cells

    Science.gov (United States)

    Khaled, Firas; Ondel, Olivier; Allard, Bruno; Buret, François

    2015-07-01

    The microbial fuel cell (MFC) converts electrochemically organic matter into electricity by means of metabolisms of bacteria. The MFC power output is limited by low voltage and low current characteristics in the range of microwatts or milliwatts per litre. In order to produce a sufficient voltage level (>1.5 V) and sufficient power to supply real applications such as autonomous sensors, it is necessary to either scale-up one single unit or to connect multiple units together. Many topologies of connection are possible as the serial association to improve the output voltage, or the parallel connection to improve the output current or the series/parallel connection to step-up both voltage and current. The association of MFCs in series is a solution to increase the voltage to an acceptable value and to mutualize the unit's output power. The serial association of a large number of MFCs presents several issues. The first one is the hydraulic coupling among MFCs when they share the same substrate. The second one is the dispersion between generators that lead to a non-optimal stack efficiency because the maximum power point (MPP) operation of all MFCs is not permitted. Voltage balancing is a solution to compensate non-uniformities towards MPP. This paper presents solutions to improve the efficiency of a stack of serially connected MFCs through a voltage-balancing circuit. Contribution to the topical issue "Electrical Engineering Symposium (SGE 2014)", edited by Adel Razek

  14. The ATLAS pixel stave emulator for serial powering

    International Nuclear Information System (INIS)

    A serial powering scheme is being developed for the upgrade of the ATLAS pixel detector in view of sLHC. It offers in fact significant advantages over the presently used parallel powering scheme, namely reduced material budget in active area and power losses on cables, smaller number of power supplies, and no need for external, distant regulation of voltages. The development of this powering scheme requires not only the design of custom-developed voltage regulators, the basic elements of serial powering, but also the early study of system aspects connected to it, for instance the safety of the powering chain and AC-coupled data transmission. To this aim a test system emulating an ATLAS pixel stave is being developed. It will provide a realistic environment to test both concepts and sub-components. Due to its flexibility, it will offer the possibility to study not only serial powering concepts, but more generally system aspects related to the ATLAS pixel detector. In particular alternative powering schemes, data coding schemes, physical layer data transmission, and Detector Control System concepts will also be evaluated with this test system. The description and development of the ATLAS pixel stave emulator are presented and first results are discussed

  15. Cognitive, emotional and social markers of serial murdering.

    Science.gov (United States)

    Angrilli, Alessandro; Sartori, Giuseppe; Donzella, Giovanna

    2013-01-01

    Although criminal psychopathy is starting to be relatively well described, our knowledge of the characteristics and scientific markers of serial murdering is still very poor. A serial killer who murdered more than five people, KT, was administered a battery of standardized tests aimed at measuring neuropsychological impairment and social/emotional cognition deficits. KT exhibited a striking dissociation between a high level of emotional detachment and a low score on the antisocial behavior scale on the Psychopathy Checklist-Revised (PCL-R). The Minnesota Multiphasic Personality Inventory-2 showed a normal pattern with the psychotic triad at borderline level. KT had a high intelligence score and showed almost no impairment in cognitive tests sensitive to frontal lobe dysfunction (Wisconsin Card Sorting Test, Theory of Mind, Tower of London, this latter evidenced a mild impairment in planning performance). In the tests on moral, emotional and social cognition, his patterns of response differed from matched controls and from past reports on criminal psychopaths as, unlike these individuals, KT exhibited normal recognition of fear and a relatively intact knowledge of moral rules but he was impaired in the recognition of anger, embarrassment and conventional social rules. The overall picture of KT suggests that serial killing may be closer to normality than psychopathy defined according to either the DSM IV or the PCL-R, and it would be characterized by a relatively spared moral cognition and selective deficits in social and emotional cognition domains.

  16. Comparative Analysis of Serial Decision Tree Classification Algorithms

    Directory of Open Access Journals (Sweden)

    Matthew Nwokejizie Anyanwu

    2009-09-01

    Full Text Available Classification of data objects based on a predefined knowledge of the objects is a data mining and knowledge management technique used in grouping similar data objects together. It can be defined as supervised learning algorithms as it assigns class labels to data objects based on the relationship between the data items with a pre-defined class label. Classification algorithms have a wide range of applications like churn prediction, fraud detection, artificial intelligence, and credit card rating etc. Also there are many classification algorithms available in literature but decision trees is the most commonly used because of its ease of implementation and easier to understand compared to other classification algorithms. Decision Tree classification algorithm can be implemented in a serial or parallel fashion based on the volume of data, memory space available on the computer resource and scalability of the algorithm. In this paper we will review the serial implementations of the decision tree algorithms, identify those that are commonly used. We will also use experimental analysis based on sample data records (Statlog data sets to evaluate the performance of the commonly used serial decision tree algorithms

  17. Introduction of serial architecture for small CNC facilities

    Directory of Open Access Journals (Sweden)

    R.A. Mahdavinejad

    2009-09-01

    Full Text Available Purpose: The concept of open-architecture control, which has been used as a main method of control in many branches such as automatic systems of machining, robotics, testing and control, causes a great increment in efficiency and precision of control systems and dynamic capability to industrial control networks.Design/methodology/approach: The high execution costs in one hand and unnecessary usage of all OAC standard components on the other hand, makes the modeling of OAC concept impossible for such systems.Findings: This paper tries to represent a simple system based on elimination of unessential elements of open-architecture to reach a limited and efficient control system.Research limitations/implications: In hierarchical architecture systems, regarding to the synchronous processes of calculation and controlling, the total execution time is very low in comparison with similar serial system. In spite of this, the execution time of synchronous processes in serial architecture is lower than hierarchical one.Practical implications: The utilization of one processor instead of multiple one, merging the industrial control network layer into system management layer and omission of processor execution layer in each axis and optimized using of multi-tasking capability of processor.Originality/value: The analysis of simulated data in motions with higher degrees of freedom shows that the usage of CNC machines with serial architecture for higher than 3-degrees of freedom is unaccepted due to large increment in total machining time.

  18. Primary School Pupils’ Attitude Towards Violence in the TV Serial: Arka Sokaklar

    OpenAIRE

    Gedik, Ezgi

    2014-01-01

    ABSTRACT: The study seeks to explore violence in Arka Sokaklar (Back Streets) serial on children. The aforementioned serial is a detective serial and is very popular both in Turkey and Turkish Republic of Northern Cyprus. It is on the air in a national channel in Turkey. Old episodes are during the weekdays; yet new episodes are on Saturday nights. Arka Sokaklar serial started to be broadcasted in 2006 and managed to be still on up to today. It is a detective serial that presents a different ...

  19. Serial measurements of serum human placental lactogen (hPL) and serial ultrasound examinations in the evaluation of fetal growth

    DEFF Research Database (Denmark)

    Sørensen, Steen; von Tabouillot, D; Schioler, V;

    2000-01-01

    Serial serum hPL measurements and serial ultrasound fetometry were compared in the evaluation of fetal growth by relating these two parameters to size at birth and to clinical factors known to influence size at birth. The data were from a prospective study of 1000 consecutive pregnant women...... deviation, smoking in pregnancy and diagnosis of preeclampsia. A significant correlation was found between the hPL-slope and the intrauterine fetal growth velocity (r=0.34), and between hPL-slope and birth weight deviation (r=0.32). Mean hPL was correlated to birth weight deviation (r=0.27), but only very...... weakly to intrauterine growth velocity (r=0.08). hPL-slope and intrauterine growth velocity independently predicted birth weight deviation. Heavy smoking which was stopped before the third trimester was not associated with low intrauterine growth velocity, but with a low hPL-slope. Preeclampsia...

  20. Regression of coronary atherosclerosis by simvastatin: a serial intravascular ultrasound study

    DEFF Research Database (Denmark)

    Jensen, Lisette Okkels; Thayssen, Per; Pedersen, Knud Erik;

    2004-01-01

    . The aim of this study was to investigate the effect of lipid lowering by simvastatin on coronary atherosclerotic P+M as changes in volumes of EEM, P+M, and lumen. METHODS AND RESULTS: In 40 male patients with hypercholesterolemia, ischemic heart disease, and a nonsignificant coronary artery lesion......BACKGROUND: Angiography of the coronary arteries reflects only changes in luminal dimensions. With intravascular ultrasound, cross-sectional images can be obtained and area measurements can be added to calculate volumes of the external elastic membrane (EEM), plaque plus media (P+M), and lumen...... in a not previously revascularized coronary artery, serial intravascular ultrasound studies with an ECG-triggered pullback were performed at baseline, after 3 months on a lipid-lowering diet, and after another 12 months on simvastatin 40 mg/d. Mean length of the analyzed atherosclerotic segments was 5.9+/-3.3 mm...

  1. Alexander Ya. Orolv - Well-Known Scientist and Recognized Organizer of Astronmoical Research. Little Known Facts of His Life

    Science.gov (United States)

    Yatskiv, Ya. S.; Vavilova, I. B.; Korsun', A. A.

    Alexander Ya. Orlov is a well-known astronomer and geophysicist as well as a worldrecognized organizer of scientific research in Russia, the USSR, and Ukraine. Orlov has formulated his main scientific ideas during the Odesa's period of life. He studied a tidal deformation of the Earth and its polar motion using the gravity and latitude observations. He has proposed new defenitions of a mean pole and a mean latitude, as wel as a new method for determing the Earth pole coordinates. To the end of 1940-ties, the Orlov's scientific ideas were implemented and stimulated a development of a research field, which is now called as Astrogeodynamics or Space Geodynamics. Among the representatives of the Orlov's scientific school are about 20 Doctors of Sciences and more than 40 Candidates of Sciences, including the members of Academy of Sciences of Ukraine and other countries. Among them are N.Stoyko-Radilenko (France), J.Witkowski (Poland), V.Zhardetsky (Yugoslavia-Austria-USA), D.Pyaskovsky, Z.Aksent'eva, E.Lavrentieva, N.Popov, E.Fedorov and A.Korol in Ukraine. The deserved followers of the Orlov's scientific ideas were also I.Androsov, I.Dyukov, K.Mansurova, B.Novopashennyj, N.V.Zimmerman in Russia and M.Bursa (Chesh Republic), who worked with him, as well as his sons, A.A.Orlov and B.A. Orlov. The Orlov's life and scientific activity were fully described in many articles. For that reason in this paper we will focus on the little-known facts of the Orlov's scientific-organizational activity, for example, the Orlov's appointments as a director of observatories in Odesa, Poltava, m.Pip-Ivan, Pulkovo, and Kyiv; interesesting facts related to his membership in the Academies of Sciences of the USSR and Ukrainian SSR; organization of a large-scale program on the latitude observations and gravimetric survey. We describe briefly his life and his astrogeodynamic scientific school.

  2. Geosciences Information for Teachers (GIFT) Workshops held in Conjunction with Alexander von Humboldt (AvH) EGU Conferences

    Science.gov (United States)

    Laj, Carlo; Cifelli, Francesca

    2015-04-01

    The Alexander von Humboldt Conference Series of the European Geosciences Union are a series of meetings held outside of Europe, in particular in South America, Africa or Asia, on selected topics of geosciences with a socio-economic impact for regions on these continents, jointly organised with the scientists and their institutes and the institutions of these regions. Given the increasing success of the GIFT workshops held in conjunction with the General Assemblies, since 2010 EGU has also developed a series of GIFT workshops held in conjunction with AvH conferences. Associated GIFT workshops were held in Merida, Yucatan, on the theme of Climate Change, Natural Hazards and Societies (March 2010), then in Penang, Malaysia (June 2011) on the theme of Ocean Acidification, in November 2012 in Cusco (Peru) on the theme of Natural Disasters, Global Change and the Preservation of World Heritage Sites, finally in Istanbul (March 2014) on "High Impact Natural Hazards Related to the Euro-Mediterranean Region. The next GIFT workshop is already planned for October 2015 in Adis Ababa (Ethiopia) on the theme "Water". In each case, the GIFT workshop was held on the last two days of the AvH conference and reunited 40-45 teachers from the nation where the AvH was held. Keynote speakers from AvH were speakers to the GIFT workshops which also included hands-on activities animated by sciences educators. These GIFT workshops represented the first workshops specifically aimed at teachers held in the country, and therefore represents a significant Earth Sciences contribution to secondary education in non European countries.

  3. Inorganic positive uniaxial films fabricated by serial bideposition.

    Science.gov (United States)

    Hodgkinson, Ian; Wu, Qi Hong; De Silva, Lakshman; Arnold, Matthew

    2004-08-01

    The physical vapor deposition process of serial bideposition is adapted to the fabrication of uniaxial optical coatings. During the coating process the vapor impinges at an angle of incidence of about 70 on to the substrate, and a stepwise axial rotation with 90 increments causes a columnar structure to grow normal to the substrate. Symmetry considerations that follow from the choice of 90 for the stepwise increment ensure that the film is achiral and has negligible in-plane linear birefringence. Optical characterization techniques confirm that films of tantalum oxide, titanium oxide and zirconium oxide are positive uniaxial with ne -no in the range 0.10 to 0.14. PMID:19483917

  4. Lean buffering in serial production lines with Bernoulli machines

    Directory of Open Access Journals (Sweden)

    A. B. Hu

    2006-01-01

    Full Text Available Lean buffering is the smallest buffer capacity necessary to ensure the desired production rate of a manufacturing system. In this paper, analytical methods for selecting lean buffering in serial production lines are developed under the assumption that the machines obey the Bernoulli reliability model. Both closed-form expressions and recursive approaches are investigated. The cases of identical and nonidentical machines are analyzed. Results obtained can be useful for production line designers and production managers to maintain the required production rate with the smallest possible inventories.

  5. 日立全新Serial ATA硬盘

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    日立环球存储科技公司推出全新ATA/Serial ATA台式机硬盘。日立Deskstar 7K250的3.5英寸硬盘通过80GB以上的单碟容量科技能提供达四分之一Terabyte的容量(Iterabyte为1000GB;1/4terabyte即250GB)。日立全新7200RPM硬盘专为传统台式设计,

  6. POSSIBILITIES OF INCREASING EFFICIENCY WITHIN SERIAL PRODUCTION MANAGEMENT

    Directory of Open Access Journals (Sweden)

    CODRUŢA DURA

    2010-01-01

    Full Text Available Under the impact of transition to the new post-industrial society, massproduction recently faced the most numerous difficulties. They are caused by turbulences in theexternal environment in which companies operate, manifested in particular by enhancing thedynamism of markets and by deep changes in the structure of consumers’ demands. In thiscontext, specialized literature records the concerns for increasing the efficiency and flexibilityof products, elements involving radical changes of management and manufacturingtechnologies methods. Given these issues, the paper approaches two separate ways to improvethe management of serial production: increasing economic efficiency by optimizing the size ofbatches and flexible production systems by implementing techniques to reduce the change-overtime.

  7. Word-serial Architectures for Filtering and Variable Rate Decimation

    Directory of Open Access Journals (Sweden)

    Eugene Grayver

    2002-01-01

    Full Text Available A new flexible architecture is proposed for word-serial filtering and variable rate decimation/interpolation. The architecture is targeted for low power applications requiring medium to low data rate and is ideally suited for implementation on either an ASIC or an FPGA. It combines the small size and low power of an ASIC with the programmability and flexibility of a DSP. An efficient memory addressing scheme eliminates the need for power hungry shift registers and allows full reconfiguration. The decimation ratio, filter length and filter coefficients can all be changed in real time. The architecture takes advantage of coefficient symmetries in linear phase filters and in polyphase components.

  8. SERIAL SECTIONS THROUGH A CONTINUOUS FIBER-REINFORCED POLYMER COMPOSITE

    Directory of Open Access Journals (Sweden)

    Laurent Bizet

    2011-05-01

    Full Text Available The microstructure of a unidirectional glass-fiber composite material is described seeking especially for the influence of the stitching perpendicular to the reinforcement. Serial cuts are performed through the composite and the microstructure is quantified using global parameters and linear morphological analysis. A key result is that the stitching induces variations in fibers spacing within the yarns and in the matrix volume between the yarns. This can affect noticeably the flow of the resin during the manufacturing process and also the mechanical properties of the composite.

  9. Analyzing the Ruling Measures of Alexander the Great in Eastern Areas%亚历山大东方治理措施探析

    Institute of Scientific and Technical Information of China (English)

    武晓阳

    2016-01-01

    With the military victory and the continuous progress of the expedition, Alexander the Great confronted the difficulties in ruling the conquered eastern areas. Alexander the Great explored actively and practiced boldly. He enhanced the relationship with the eastern aristocrats and broadened the foundation of new empire through marriage and through adopting the eastern ceremonies and habitude. Relying on the Alexandria newly created, with the measures above mentioned and others as well, Alexander the Great con-trolled his empire firmly and basically maintained the stability of the eastern areas.%随着军事胜利和远征的不断推进,如何治理被征服的东方地区成为亚历山大亟待解决的问题。亚历山大积极探索,大胆实践,主动采用东方的礼仪习俗,并通过联姻方式,加强与东方贵族的联系,拓宽新兴帝国的基础,以新建的众多亚历山大城为中心点,实施多种管理方式,同时还严惩地方总督和将领的不法行为,加强对东方的管理。通过这些举措,基本上维持了东方统治区域的稳定。

  10. Rethinking Conceptual Definitions of the Criminal Career and Serial Criminality.

    Science.gov (United States)

    Edelstein, Arnon

    2016-01-01

    Since Cesare Lombroso's days, criminology seeks to define, explain, and categorize the various types of criminals, their behaviors, and motives. This aim has theoretical as well as policy-related implications. One of the important areas in criminological thinking focuses chiefly on recidivist offenders who perform large numbers of crimes and/or commit the most dangerous crimes in society (rape, murder, arson, and armed robbery). These criminals have been defined as "habitual offenders," "professional criminals," "career criminals," and "serial offenders." The interest in these criminals is a rational one, given the perception that they present a severe threat to society. The main challenge in this area of research is a conceptual problem that has significant effects across the field. To this day, scholars have reused and misused titles to define and explain different concepts. The aim of this article is 3-fold. First, to review the concepts of criminal career, professional crime, habitual offenses, and seriality with a critical attitude on confusing terms. Second, to propose the redefinition of concepts mentioned previously, mainly on the criminal career. Third, to propose a theoretical model to enable a better understanding of, and serve as a basis for, further research in this important area of criminology.

  11. Serial femtosecond crystallography: A revolution in structural biology.

    Science.gov (United States)

    Martin-Garcia, Jose M; Conrad, Chelsie E; Coe, Jesse; Roy-Chowdhury, Shatabdi; Fromme, Petra

    2016-07-15

    Macromolecular crystallography at synchrotron sources has proven to be the most influential method within structural biology, producing thousands of structures since its inception. While its utility has been instrumental in progressing our knowledge of structures of molecules, it suffers from limitations such as the need for large, well-diffracting crystals, and radiation damage that can hamper native structural determination. The recent advent of X-ray free electron lasers (XFELs) and their implementation in the emerging field of serial femtosecond crystallography (SFX) has given rise to a remarkable expansion upon existing crystallographic constraints, allowing structural biologists access to previously restricted scientific territory. SFX relies on exceptionally brilliant, micro-focused X-ray pulses, which are femtoseconds in duration, to probe nano/micrometer sized crystals in a serial fashion. This results in data sets comprised of individual snapshots, each capturing Bragg diffraction of single crystals in random orientations prior to their subsequent destruction. Thus structural elucidation while avoiding radiation damage, even at room temperature, can now be achieved. This emerging field has cultivated new methods for nanocrystallogenesis, sample delivery, and data processing. Opportunities and challenges within SFX are reviewed herein.

  12. Serial Contradictions. The Italian Debate on Tv Series

    Directory of Open Access Journals (Sweden)

    Daniela Cardini

    2016-06-01

    Full Text Available In the last decade the academic debate on television seriality has become lively and often quite animated, in the US as well as in Italy. The traditional hierarchic relation between cinema and television is clearly represented by the form of the most recent tv drama, whose boundaries are more and more difficult to locate. The main questions at stake seem to be the so-called “cinematic television” (Mills, 2013; Jaramillo, 2013, the umbrella definition of “quality tv” (McCabe and Akass, 2007 and its relation with the broadest concept of “complex tv” (Mittell, 2009, 2015. The essay will take into consideration these oxymorons, which are deeply rooted in the Italian tv series debate, with the aim of considering both their risks and their opportunities. A great variety of texts are grouped under the “tv series” label, but they are very different as far as content, production values and audience reactions are concerned. The academic discourse, however, only recently has tried to identify the differences between longstanding mainstream shows (such as, for instance, Grey’s Anatomy or CSI and some more recent, and supposedly “cinematic” series like True Detective or Fargo. Together with the analysis of the oxymoric nature of recent television seriality, the essay will explore the need to historicising what is proving to be one of the most dense and fruitful domains of recent television studies.

  13. Serial crystallography on in vivo grown microcrystals using synchrotron radiation

    Directory of Open Access Journals (Sweden)

    Cornelius Gati

    2014-03-01

    Full Text Available Crystal structure determinations of biological macromolecules are limited by the availability of sufficiently sized crystals and by the fact that crystal quality deteriorates during data collection owing to radiation damage. Exploiting a micrometre-sized X-ray beam, high-precision diffractometry and shutterless data acquisition with a pixel-array detector, a strategy for collecting data from many micrometre-sized crystals presented to an X-ray beam in a vitrified suspension is demonstrated. By combining diffraction data from 80 Trypanosoma brucei procathepsin B crystals with an average volume of 9 µm3, a complete data set to 3.0 Å resolution has been assembled. The data allowed the refinement of a structural model that is consistent with that previously obtained using free-electron laser radiation, providing mutual validation. Further improvements of the serial synchrotron crystallography technique and its combination with serial femtosecond crystallography are discussed that may allow the determination of high-resolution structures of micrometre-sized crystals.

  14. Emotional and coping responses to serial killings. The Gainesville murders.

    Science.gov (United States)

    Norvell, N K; Cornell, C E; Limacher, M C

    1993-07-01

    Forensic experts have focused more on the psychological profile of a serial killer rather than on the pronounced effects on the community at large. Coping with a stressful event is thought to influence emotional states. However, little empirical understanding of this process exists. The present study examined changes in psychological factors 9 days after the occurrence of serial killings in a college community. Multivariate analyses of variance conducted on the variables of stress, anxiety, physical symptoms, and depression revealed a significant difference between the group tested after the murders and a cross-sectional cohort group. Univariate analyses revealed that the study class was significantly more depressed compared with the cohort group. The study class was also significantly more depressed compared with their own responses 1 year before the killings. For both classes, depression was significantly correlated with certain coping styles, including escape-avoidance and accept responsibility. Results have implications for certain coping behaviors (i.e., avoidant behaviors), such as that leaving the community may have been maladaptive and perhaps diverted attention from the more necessary active problem-solving behaviors (e.g., increasing security) in addition to increasing depression.

  15. Serial femtosecond crystallography: A revolution in structural biology.

    Science.gov (United States)

    Martin-Garcia, Jose M; Conrad, Chelsie E; Coe, Jesse; Roy-Chowdhury, Shatabdi; Fromme, Petra

    2016-07-15

    Macromolecular crystallography at synchrotron sources has proven to be the most influential method within structural biology, producing thousands of structures since its inception. While its utility has been instrumental in progressing our knowledge of structures of molecules, it suffers from limitations such as the need for large, well-diffracting crystals, and radiation damage that can hamper native structural determination. The recent advent of X-ray free electron lasers (XFELs) and their implementation in the emerging field of serial femtosecond crystallography (SFX) has given rise to a remarkable expansion upon existing crystallographic constraints, allowing structural biologists access to previously restricted scientific territory. SFX relies on exceptionally brilliant, micro-focused X-ray pulses, which are femtoseconds in duration, to probe nano/micrometer sized crystals in a serial fashion. This results in data sets comprised of individual snapshots, each capturing Bragg diffraction of single crystals in random orientations prior to their subsequent destruction. Thus structural elucidation while avoiding radiation damage, even at room temperature, can now be achieved. This emerging field has cultivated new methods for nanocrystallogenesis, sample delivery, and data processing. Opportunities and challenges within SFX are reviewed herein. PMID:27143509

  16. SERIAL EFFECTS OF EVIDENCE ON LEGAL DECISION-MAKING

    Directory of Open Access Journals (Sweden)

    Raluca Enescu

    2012-07-01

    Full Text Available The order in which evidence is presented to a criminal court might influence the verdict. This study investigated the serial position effect in a judicial context. 1831 Swiss criminal judges received a filmed mock trial with a specific order stemming from the combination of 3 witnesses: a forensic expert, an eyewitness and an alibi witness. The evidence order was completely counterbalanced and each witness represented a different type of testimony chosen in accordance with the legal practice. If judges rendered their verdict on the basis of the first witness, a primacy effect would be observed. Conversely, if the last testimony would be preponderant, a recency effect would influence their judgment. Results showed a recency effect based on a defence eyewitness whose placement in the last position provoked significantly less condemnations. Furthermore, the probative value estimated by the judges for each piece of evidence was not associated with its serial impact. Results are discussed in relation to legal decision-making and the identification of a central witness mediating order effects.

  17. Entre a batuta e o tubo de ensaio: a carreira admirável de Alexandre Borodin Between baton and test tube: the admirable career of Alexander Borodin

    Directory of Open Access Journals (Sweden)

    Carlos A. L. Filgueiras

    2002-11-01

    Full Text Available Alexander Borodin (1833-1887 is a singularity in the history of science. Whereas other scientists may have kept lifelong interests in some artistic field, he was unique in pursuing with great success two parallel careers in both chemistry and music, managing to excell in both to the end of his life. Although he considered himself primarily a chemist, present-day appreciation of his powerful music has greatly surpassed interest for his chemistry. This article treats the life and the unusual double career of the Russian chemist-musician.

  18. Deceit, desire, and The Dunciad: mimetic theory and Alexander Pope – and – Birthing the canon: Eliot, Hegel, Marx and literary labour

    OpenAIRE

    Doolittle, Allan Laurence

    2008-01-01

    Essay 1: This paper analyses Alexander Pope’s depiction of apocalypse in his seminal satiric masterpiece, The Dunciad. Rene Girard’s mimetic theory explains Pope’s relationship to his literary rivals and his motivation in writing, expanding and obsessing over this work throughout the entire course of his life. This paper reads Pope’s literary and critical efforts to control the literary scene of early eighteenth-century England in a Girardian framework. Essay 2: This two-part study examines t...

  19. Saint Sisoes above the grave of Alexander the Great. A monastic theme of post-Byzantine art and its examples from the 17th century Serbian painting

    OpenAIRE

    Živković Miloš

    2013-01-01

    The depiction of St. Sisoes above the grave of Alexander the Great was formulated at the end of the 15th century. The image in question is a visual interpretation of a short song («I see you, grave»), and it was often painted in the churches throughout the Balkans during the next two centuries. With references to the textual basis of this iconographic theme, as well as its meaning, the article is devoted to insufficiently studied Serbian examples of frescoe...

  20. Una propuesta de la integración psicocorporal a través de la técnica Alexander y la danza movimiento terapia

    OpenAIRE

    Martínez Martínez, Laura; Pérez Testor, Susana

    2012-01-01

    Este trabajo es una propuesta de integración de la Técnica Alexander y la Danza Movimiento Terapia. Partiendo de la realidad de que ambas técnicas tienen como objetivo final la integración de la dimensión de la psique, del cuerpo y de la emoción, para restaurar el equilibrio integral del ser humano que como consecuencia aporta un estado de salud al individuo. Cada una de ellas se posiciona sobre un camino diferente hacia la curación, aunque comparten muchas bases en común. Una de ellas trata ...

  1. INSECTOS DE LA ORINOQUIA COLOMBIANA: EVALUACIÓN A PARTIR DE LA COLECCIÓN ENTOMOLÓGICA DEL INSTITUTO ALEXANDER VON HUMBOLDT (IAVH)

    OpenAIRE

    IRINA T MORALES-CASTAÑO; Medina U., Claudia Alejandra

    2009-01-01

    A partir de la revisión de insectos de la Colección Entomológica del Instituto Alexander von Humboldt (IAvH), provenientes de la región de la Orinoquia colombiana, se realizó una lista preliminar de los insectos de esta región. En la presente contribución se amplía el conocimiento de cuatro órdenes de insectos (Coleoptera, Dictyoptera, Hemiptera e Hymenoptera), encontrándose 168 especies, pertenecientes a 156 géneros, 59 tribus, 39 subfamilias y 15 familias. Se presentan 84 nuevos registros p...

  2. The Neotropical tanyderid Araucoderus gloriosus (Alexander) (Diptera, Tanyderidae), with description of the egg, larva and pupa, redescription of adults, and notes on natural history.

    Science.gov (United States)

    Madriz, R Isaí; Courtney, Gregory W

    2016-01-01

    Larvae, pupae and adults of Araucoderus gloriosus (Alexander) were collected during fieldwork in Chilean Patagonia, December 2013 and January 2014. Eggs were obtained from females that oviposited in captivity. Association of all life stages is based on co-occurrence and rearing of individual larvae to adults. A diagnosis for the genus and species is provided. Descriptions of the egg, larva and pupa and redescriptions of the male and female are completed. Eggs of A. gloriosus are the first described for Tanyderidae. Natural history characteristics for this species, including microhabitat, copulatory behavior and oviposition, are discussed. PMID:27615889

  3. On the Performance of the Python Programming Language for Serial and Parallel Scientific Computations

    OpenAIRE

    Xing Cai; Hans Petter Langtangen; Halvard Moe

    2005-01-01

    This article addresses the performance of scientific applications that use the Python programming language. First, we investigate several techniques for improving the computational efficiency of serial Python codes. Then, we discuss the basic programming techniques in Python for parallelizing serial scientific applications. It is shown that an efficient implementation of the array-related operations is essential for achieving good parallel performance, as for the serial case. Once the array-r...

  4. The Organized/Disorganized Typology of Serial Murder: Myth or Model?

    OpenAIRE

    Canter, David V.; Alison, Laurence J.; Alison, Emily; Wentink, Natalia

    2004-01-01

    Despite weaknesses in the organized/disorganized classification of serial killers, it is drawn on for "offender profiles," theories of offending, and in murder trials. This dichotomy was therefore tested by the multidimensional scaling of the co-occurrence of 39 aspects of serial killings derived 100 murders committed by 100 U.S. serial killers. Results revealed no distinct subsets of offense characteristics reflecting the dichotomy. They showed a subset of organized features typical of most ...

  5. Implementation of Serial Shipping Container Code as a component of Electronic Data Interchange

    OpenAIRE

    Typovský, Martin

    2014-01-01

    Typovsky, M. Implementation of Serial Shipping Container Code as a component of Electronic Data Interchange. Bachelor thesis. Brno: FBE Mendel university in Brno 2014. This bachelor thesis deals with functioning of Serial Shipping Container Code in process of sending business documents inside of supply chain. The main objective is to analyze implementation process of Serial Shipping Container Code. Through evaluation of survey, quantification of benefits and cost is done for both Electronic D...

  6. Serial Monodomy in the Gypsy Ant, Aphaenogaster araneoides: Does Nest Odor Reduction Influence Colony Relocation?

    OpenAIRE

    McGlynn, Terry

    2010-01-01

    Serial monodomy is the nesting behavior in which a colony of animals maintains multiple nests for its exclusive use, occupying one nest at a time. Among serially monodomous ants, the availability of unoccupied nests reduces the probability and costs of army ant attacks. It has been proposed that nest odors mediate serial monodomy in the gypsy ant, Aphaenogaster araneoides Emery (Hymenoptera: Formicidae), and that colonies avoid returning to previously occupied nests that harbor colony odors. ...

  7. 三星首款Serial ATA硬盘 三得SP1614C

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    不可否认,Serial ATA已经成为新一代硬盘的接口标准,各个硬盘厂商的serialATA硬盘已经纷纷在市场上销售。最近.三星公司也推出了自己的首款采用SerialATA接口的硬盘产品——三星SPl614C。

  8. Effects of Age on Serial Recall of Natural and Synthetic Speech

    OpenAIRE

    Humes, Larry E.; Nelson, Kathleen J.; Pisoni, David B.; Lively, Scott E.

    1993-01-01

    The present study addressed the effects of aging on auditory serial-recall performance for natural and synthetic words. Word difficulty, measured in terms of frequency of occurrence and phonological similarity, and rate of presentation were also manipulated in an effort to determine which processes underlying serial-recall performance, if any, were affected by aging. Results indicated that age per se had little effect on short-term (working) memory as measured by the serial recall of monosyll...

  9. A low-power, radiation-hard gigabit serializer for use in the CMS electromagnetic calorimeter

    CERN Document Server

    Denes, P; Bussat, J M; Wixted, R

    2000-01-01

    An integrated fiber-optic bit serializer and VCSEL driver has been constructed in radiation-hard complementary heterostructure GaAs FET (CHFET) technology. The serializer, which converts 20 parallel inputs into a high-speed serial output, consumes 60 mW at nominal supply voltage when operating at the Large Hadron Collider word rate of 40 MHz (0.8-GB/s serial rate). The integrated driver directly drives a VCSEL and provides 10-mA switched current and 5 mA of prebias. The complete digital optical link thus consumes 90 mW. (6 refs).

  10. Management of serial ECGs and control strategies for the comparison process.

    Science.gov (United States)

    Fayn, J; Rubel, P; Willems, J L

    1994-03-01

    Serial ECG management and control of the comparison process should be dynamically driven by patient data. The functional architecture requirements are specified for a computerized ECG processing system integrating serial analysis. The concepts of reference investigations and temporal events are first explained. A conceptual reference model is proposed which stratifies the serial analysis process into a few generic strategies which will be instantiated into several types of serial comparison processing tasks as a function of the clinical evolution of the patient. This model is an extension of the OEDIPE core data model developed and implemented during the AIM #2026 project.

  11. A low-power, radiation-hard gigabit serializer for use in the CMS electromagnetic calorimeter

    International Nuclear Information System (INIS)

    An integrated fiber-optic bit serializer and VCSEL (Vertical Cavity Surface Emitting Laser) driver has been constructed in radiation-hard complementary heterostructure GaAs FET (CHFET) technology. The serializer, which converts 20 parallel inputs into a high-speed serial output, consumes 60 mW at nominal supply voltage when operating at the Large Hadron Collider (LHC) word rate of 40 MHz (0.8-GB/s serial rate). The integrated driver directly drives a VCSEL and provides 10-mA switched current and 5 mA of prebias. The complete digital optical link thus consumes 90 mW

  12. Serial intravascular ultrasound assessment of changes in coronary atherosclerotic plaque dimensions and composition: an update

    DEFF Research Database (Denmark)

    Hartmann, Marc; Huisman, Jennifer; Böse, Dirk;

    2011-01-01

    This manuscript reviews the use of serial intravascular ultrasound (IVUS) examination of coronary atherosclerosis in recent observational studies and randomized trials that revealed the effects of cholesterol-lowering and lipid-modifying therapies and offered novel insight into plaque progression...... and regression. We discuss the value of plaque progression-regression as complementary imaging endpoint and potential surrogate marker of cardiovascular event risk. In addition, the progress in serial assessment of coronary plaque composition and plaque vulnerability by radiofrequency-based analyses is reviewed....... Finally, we report on the evaluation of true vessel remodelling in recent serial IVUS trials and discuss the future perspective of serial invasive imaging of coronary atherosclerosis....

  13. Serial measurements of serum human placental lactogen (hPL) and serial ultrasound examinations in the evaluation of fetal growth

    DEFF Research Database (Denmark)

    Sørensen, Steen; von Tabouillot, D; Schioler, V;

    2000-01-01

    Serial serum hPL measurements and serial ultrasound fetometry were compared in the evaluation of fetal growth by relating these two parameters to size at birth and to clinical factors known to influence size at birth. The data were from a prospective study of 1000 consecutive pregnant women...... considered to be at risk for fetal growth retardation with retrospective analysis. Serum hPL was measured by radioimmunoassay and fetal weight estimated by ultrasound every 3 weeks during the last trimester. hPL values were expressed as multiples of the median (MoM) and linear regression analysis of the h......PL MoM values was carried out for each pregnancy to find the slope of the line (hPL-slope); at least 3 serum hPL values were required. The estimated fetal weight and weight-for-age at birth was expressed in Z-scores. The individual intrauterine growth velocity was calculated by regression analysis and...

  14. Serial transfer of a transplantable tumor: implications for Marek's vaccine mechanisms.

    Science.gov (United States)

    Hunt, Henry D; Dunn, John R

    2011-06-01

    The mechanism of Marek's disease (MD) vaccination to prevent the lymphoproliferative disease in chickens is not well understood. It is generally recognized that vaccination prevents disease, including the induction of T-cell tumors, but it does not prevent the pathogenic virus from infecting and replicating in the vaccinated host, nor does it prevent bird to bird spread of the oncogenic virus. The stage at which the vaccinated immune system intervenes in the process from infection to the induction of tumors remains obscure. Using a transplantable tumor induced by the Md5 strain of MD virus (MDV), we show that CVI988 vaccination does not prevent the induction of transplantable tumors in the 15I(5) x 7(1) chicken line. A monoclonal tumor with a V beta 1 T-cell receptor spectratype of 207 base pairs was used to follow the transplantable tumor in serial passages in vivo. This transplantable tumor could be passed in vaccinated birds. The length of time between vaccination and challenge (5 to 12 days) had little or no influence on the ability to transfer the tumor. There was variability in the manifestation of the disease produced by the transplanted tumor. Some chickens presented as normal but were still capable of transmitting the transplanted tumor to newly vaccinated recipients via their blood. This indicates that some chickens can control, but not eliminate, the tumor. The variables inducing health or disease in the challenged chickens remain obscure, but environmental or other factors likely depress the immune system allowing the tumor to overwhelm the immune system.

  15. Capilaroscopia periungueal seriada (CPU como parâmetro de monitoramento da evolução de pacientes com diagnóstico inicial de fenômeno de Raynaud (FRy isolado ou de doença indiferenciada do tecido conjuntivo (DITC Serial nailfold capillaroscopy (NFC as a tool for prospective evaluation of patients with initial isolated Raynaud's phenomenon (RP or undifferentiated connective tissue disease (UCDT

    Directory of Open Access Journals (Sweden)

    Viviane Shinsato Higashi

    2005-12-01

    Raynaud's phenomenon (RP or undifferentiated connective tissue disease (UCTD. METHODS: We evaluated 19 patients with previous diagnosis of isolated Raynaud's Phenomenon or UCTD who had two or more NFC exams within at least one-year interval. RESULTS: Eleven patients have had initial diagnosis of isolated RP; seven maintained the RP diagnosis, three developed Systemic Sclerosis (SSc, and one evolved to Sjögren´s Syndrome (SSj. Eight patients were diagnosed with UCTD in the first evaluation and all of them kept the initial diagnosis. Nine patients presented changes in NFC pattern. Seven patients presented intensification of SD pattern (group A. In three of these patients, the diagnosis has evolved from isolated FRy to SSc. The remaining four cases (one RP and three UCTD maintained the initial diagnosis. Group B included two cases in which the SD pattern has been attenuated or disappeared. One of these patients has evolved from isolated RP to SSj. Ten patients had the NFC pattern unaltered (Group C and all of them have kept the initial diagnosis (four with UCTD and six with RP. All patients who had evolved to SSc have shown intensification or appearance of SD pattern (sensitivity=100%. On the other hand, among the 16 patients who have not evolved to SSc, 12 had not shown appearance or intensification of SD pattern (specificity=75%. CONCLUSIONS: The appearance or intensification of SD pattern in serial NFC analysis during the study period has shown high sensitivity and moderate specificity in regard to the development of SSc.

  16. Alexander von Humboldts Weltbild

    Directory of Open Access Journals (Sweden)

    Eberhard Knobloch

    2009-10-01

    Full Text Available Article in German. Abstracts in German and English. The paper is divided into five sections. It begins by showing the similarity between Humboldt's world view and that of the Pythagoreans. It inquires into Humboldt's notion of nature that comprehends natura naturans and natura naturata as well. Numbers are powers of the univers. They especially occur in the 'only decisive method' that is in the method of mean values. This method makes it possible to recognize the law guiding the changes of variable quantities. The botanical arithmetic and earth magnetism provide examples. Finally the paper explains how Humboldt combined the three possible approaches to the world that is thinking, acting, and regarding by means of the notion of knowledge.

  17. Liquid sample delivery techniques for serial femtosecond crystallography.

    Science.gov (United States)

    Weierstall, Uwe

    2014-07-17

    X-ray free-electron lasers overcome the problem of radiation damage in protein crystallography and allow structure determination from micro- and nanocrystals at room temperature. To ensure that consecutive X-ray pulses do not probe previously exposed crystals, the sample needs to be replaced with the X-ray repetition rate, which ranges from 120 Hz at warm linac-based free-electron lasers to 1 MHz at superconducting linacs. Liquid injectors are therefore an essential part of a serial femtosecond crystallography experiment at an X-ray free-electron laser. Here, we compare different techniques of injecting microcrystals in solution into the pulsed X-ray beam in vacuum. Sample waste due to mismatch of the liquid flow rate to the X-ray repetition rate can be addressed through various techniques.

  18. Serial femtosecond crystallography datasets from G protein-coupled receptors.

    Science.gov (United States)

    White, Thomas A; Barty, Anton; Liu, Wei; Ishchenko, Andrii; Zhang, Haitao; Gati, Cornelius; Zatsepin, Nadia A; Basu, Shibom; Oberthür, Dominik; Metz, Markus; Beyerlein, Kenneth R; Yoon, Chun Hong; Yefanov, Oleksandr M; James, Daniel; Wang, Dingjie; Messerschmidt, Marc; Koglin, Jason E; Boutet, Sébastien; Weierstall, Uwe; Cherezov, Vadim

    2016-08-01

    We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human δ-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data.

  19. Serialization and persistent objects turning data structures into efficient databases

    CERN Document Server

    Soukup, Jiri

    2014-01-01

    Recently, the pressure for fast processing and efficient storage of large data with complex?relations increased beyond the capability of traditional databases. Typical examples include iPhone applications, computer aided design - both electrical and mechanical, biochemistry applications, and incremental compilers. Serialization, which is sometimes used in such situations is notoriously tedious and error prone.In this book, Jiri Soukup and Petr Macha?ek show in detail how to write programs which store their internal data automatically and transparently to disk. Together with special data structure libraries which treat relations among objects as first-class entities, and with a UML class-diagram generator, the core application code is much simplified. The benchmark chapter shows a typical example where persistent data is faster by the order of magnitude than with a traditional database, in both traversing and accessing the data.The authors explore and exploit advanced features of object-oriented languages in a...

  20. Bit-Serial Adder Based on Quantum Dots

    Science.gov (United States)

    Fijany, Amir; Toomarian, Nikzad; Modarress, Katayoon; Spotnitz, Mathew

    2003-01-01

    A proposed integrated circuit based on quantum-dot cellular automata (QCA) would function as a bit-serial adder. This circuit would serve as a prototype building block for demonstrating the feasibility of quantum-dots computing and for the further development of increasingly complex and increasingly capable quantum-dots computing circuits. QCA-based bit-serial adders would be especially useful in that they would enable the development of highly parallel and systolic processors for implementing fast Fourier, cosine, Hartley, and wavelet transforms. The proposed circuit would complement the QCA-based circuits described in "Implementing Permutation Matrices by Use of Quantum Dots" (NPO-20801), NASA Tech Briefs, Vol. 25, No. 10 (October 2001), page 42 and "Compact Interconnection Networks Based on Quantum Dots" (NPO-20855), which appears elsewhere in this issue. Those articles described the limitations of very-large-scale-integrated (VLSI) circuitry and the major potential advantage afforded by QCA. To recapitulate: In a VLSI circuit, signal paths that are required not to interact with each other must not cross in the same plane. In contrast, for reasons too complex to describe in the limited space available for this article, suitably designed and operated QCA-based signal paths that are required not to interact with each other can nevertheless be allowed to cross each other in the same plane without adverse effect. In principle, this characteristic could be exploited to design compact, coplanar, simple (relative to VLSI) QCA-based networks to implement complex, advanced interconnection schemes. To enable a meaningful description of the proposed bit-serial adder, it is necessary to further recapitulate the description of a quantum-dot cellular automation from the first-mentioned prior article: A quantum-dot cellular automaton contains four quantum dots positioned at the corners of a square cell. The cell contains two extra mobile electrons that can tunnel (in the

  1. Merging of synchrotron serial crystallographic data by a genetic algorithm.

    Science.gov (United States)

    Zander, Ulrich; Cianci, Michele; Foos, Nicolas; Silva, Catarina S; Mazzei, Luca; Zubieta, Chloe; de Maria, Alejandro; Nanao, Max H

    2016-09-01

    Recent advances in macromolecular crystallography have made it practical to rapidly collect hundreds of sub-data sets consisting of small oscillations of incomplete data. This approach, generally referred to as serial crystallography, has many uses, including an increased effective dose per data set, the collection of data from crystals without harvesting (in situ data collection) and studies of dynamic events such as catalytic reactions. However, selecting which data sets from this type of experiment should be merged can be challenging and new methods are required. Here, it is shown that a genetic algorithm can be used for this purpose, and five case studies are presented in which the merging statistics are significantly improved compared with conventional merging of all data. PMID:27599735

  2. Serial femtosecond crystallography datasets from G protein-coupled receptors.

    Science.gov (United States)

    White, Thomas A; Barty, Anton; Liu, Wei; Ishchenko, Andrii; Zhang, Haitao; Gati, Cornelius; Zatsepin, Nadia A; Basu, Shibom; Oberthür, Dominik; Metz, Markus; Beyerlein, Kenneth R; Yoon, Chun Hong; Yefanov, Oleksandr M; James, Daniel; Wang, Dingjie; Messerschmidt, Marc; Koglin, Jason E; Boutet, Sébastien; Weierstall, Uwe; Cherezov, Vadim

    2016-01-01

    We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human δ-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data. PMID:27479354

  3. Statistical design for a small serial dilution series.

    Science.gov (United States)

    Zelterman, Daniel; Tulupyev, Alexander; Heimer, Robert; Abdala, Nadia

    2010-02-10

    We describe statistical plans for a serial dilution series designed to detect and estimate the number of viral particles in a solution. The design addresses a problem when a very limited number of aliquots are available for proliferation. A gamma prior distribution on the number of viral particles allows us to describe the marginal probability distribution of all experimental outcomes. We examine a design that minimizes the expected reciprocal information and compare this with the maximum entropy design. We argue that the maximum entropy design is more useful from the point of view of the laboratory technician. The problem and design are motivated by our study of the viability of human immunodeficiency virus in syringes and other equipment that might mediate blood-borne viral transmission.

  4. SERIAL EFFECTS OF EVIDENCE ON LEGAL DECISION-MAKING

    Directory of Open Access Journals (Sweden)

    Raluca Enescu

    2012-07-01

    Full Text Available The order in which evidence is presentedto a criminal court might influence the verdict.This study investigated the serial position effectin a judicial context. 1831 Swiss criminal judgesreceived a filmed mock trial with a specificorder stemming from the combination of 3witnesses: a forensic expert, an eyewitness andan alibi witness. The evidence order wascompletely counterbalanced and each witnessrepresented a different type of testimony chosenin accordance with the legal practice. If judgesrendered their verdict on the basis of the firstwitness, a primacy effect would be observed.Conversely, if the last testimony would bepreponderant, a recency effect would influencetheir judgment. Results showed a recency effectbased on a defence eyewitness whose placementin the last position provoked significantly lesscondemnations. Furthermore, the probativevalue estimated by the judges for each piece of evidence was not associated with its serialimpact. Results are discussed in relation to legaldecision-making and the identification of acentral witness mediating order effects.

  5. Serial femtosecond X-ray diffraction of enveloped virus microcrystals

    Directory of Open Access Journals (Sweden)

    Robert M. Lawrence

    2015-07-01

    Full Text Available Serial femtosecond crystallography (SFX using X-ray free-electron lasers has produced high-resolution, room temperature, time-resolved protein structures. We report preliminary SFX of Sindbis virus, an enveloped icosahedral RNA virus with ∼700 Å diameter. Microcrystals delivered in viscous agarose medium diffracted to ∼40 Å resolution. Small-angle diffuse X-ray scattering overlaid Bragg peaks and analysis suggests this results from molecular transforms of individual particles. Viral proteins undergo structural changes during entry and infection, which could, in principle, be studied with SFX. This is an important step toward determining room temperature structures from virus microcrystals that may enable time-resolved studies of enveloped viruses.

  6. A Comparative Study on Serial and Parallel Web Content Mining

    Directory of Open Access Journals (Sweden)

    Binayak Panda

    2016-03-01

    Full Text Available World Wide Web (WWW is such a repository which serves every individuals need starting with the context of education to entertainment etc. But from users point of view getting relevant information with respect to one particular context is time consuming and also not so easy. It is because of the volume of data which is unstructured, distributed and dynamic in nature. There can be automation to extract relevant information with respect to one particular context, which is named as Web Content Mining. The efficiency of automation depends on validity of expected outcome as well as amount of processing time. The acceptability of outcome depends on user or user’s policy. But the amount of processing time depends on the methodology of Web Content Mining. In this work a study has been carried out between Serial Web Content Mining and Parallel Web Content Mining. This work also focuses on the frame work of implementation of parallelism in Web Content Mining.

  7. Unequal Input Voltages Distribution Between the Serial Connected Halfbridges

    Directory of Open Access Journals (Sweden)

    Radovan Ovcarcik

    2006-01-01

    Full Text Available This paper describes a topology of DC-DC converter consisting in two serial connected half-bridges. Secondary circuit is realized like a conventional full-wave rectifier. The main advantage of this topology is the possibility of dividing the input voltage between the half-bridges. The converter is controlled using the phase-shift modulation, which allows a ZVSoperation mode. The voltage unbalance between the inputs causes an important problem of the presented topology. It is necessary to avoid it by the control algorithm, which is described in the text. The practical results show a zero voltage switching technique and the limits of the chosen topology and of the control.

  8. Data processing pipeline for serial femtosecond crystallography at SACLA1

    Science.gov (United States)

    Nakane, Takanori; Joti, Yasumasa; Tono, Kensuke; Yabashi, Makina; Nango, Eriko; Iwata, So; Ishitani, Ryuichiro; Nureki, Osamu

    2016-01-01

    A data processing pipeline for serial femtosecond crystallography at SACLA was developed, based on Cheetah [Barty et al. (2014). J. Appl. Cryst.47, 1118–1131] and CrystFEL [White et al. (2016). J. Appl. Cryst.49, 680–689]. The original programs were adapted for data acquisition through the SACLA API, thread and inter-node parallelization, and efficient image handling. The pipeline consists of two stages: The first, online stage can analyse all images in real time, with a latency of less than a few seconds, to provide feedback on hit rate and detector saturation. The second, offline stage converts hit images into HDF5 files and runs CrystFEL for indexing and integration. The size of the filtered compressed output is comparable to that of a synchrotron data set. The pipeline enables real-time feedback and rapid structure solution during beamtime. PMID:27275146

  9. MISD Compiler for Feature Vector Computation in Serial Input Images

    Directory of Open Access Journals (Sweden)

    Lucas Leiva

    2011-06-01

    Full Text Available In this paper a compiler capable of generate Multiple Instruction Single Data (MISD architectures for feature vector calculation is presented. The input is a high-level language, avoiding to developers to involve in low level design. Instead, the output is expressed in a Hardware Description Language (HDL, and can be used for FPGA configuration. A FPGA is a programmable device which allows parallelism, increasing the system speed up. The tool is intended to use in feature vector calculation of region of interest (ROI for real time video applications. These ROIs arrives serially. Also, is possible to evaluate the vector in design time, allowing system prototyping. The compiler optimizes the response time and the number of registers required to meet real time constraints.

  10. Automatic failure detection of serial products using novelty filter

    Directory of Open Access Journals (Sweden)

    Márcia Helena Veleda Moita

    2013-08-01

    Full Text Available The present paper focus on a computer tool that seeks the failure detection of serial products. This paper begins with a brief description about the quality on manufacturing process and points out the relevance of product inspection for detecting fails aiming the product's quality. For such inspection to be accomplished, was used Digital Image Processing Techniques and Artificial Intelligence. This research were done in a mobile phone industry located in the Manaus Industrial Polo - PIM. The tool's methodology localize the possible defect areas and uses a process in which, from a data base composed by pattern images, the Novelty Filter Technique is able to discern regions of  failure through what it was instructed.

  11. Whole brain imaging with Serial Two-Photon Tomography

    Directory of Open Access Journals (Sweden)

    Stephen P Amato

    2016-03-01

    Full Text Available Imaging entire mouse brains at submicron resolution has historically been a challenging undertaking and largely confined to the province of dedicated atlasing initiatives. The has limited systematic investigations into important areas of neuroscience, such as neural circuits, brain mapping and neurodegeneration. In this paper, we describe in detail Serial Two-Photon (STP tomography, a robust, reliable method for imaging entire brains with histological detail. We provide examples of how the basic methodology can be extended to other imaging modalities, such as optical coherence tomography, in order to provide unique contrast mechanisms. Furthermore we provide a survey of the research that STP tomography has enabled in the field of neuroscience, provide examples of how this technology enables quantitative whole brain studies, and discuss the current limitations of STP tomography-based approaches

  12. Reversibility of hepatopulmonary syndrome evidenced by serial pulmonary perfusion scan.

    Science.gov (United States)

    Shijo, H; Sasaki, H; Sakata, H; Kusuhara, H; Ueki, T; Okumura, M

    1993-02-01

    A patient with liver cirrhosis who exhibited marked hypoxemia is presented. An abnormal dilatation of intrapulmonary capillaries was evidenced by perfusion lung scan, contrast-enhanced echocardiography, and histological examinations of lungs. Serial perfusion lung scan disclosed that the radioisotope uptake by extrapulmonary organs was significantly increased and uptake by both lungs was significantly decreased during the state of severer hypoxemia. Shunt quantification method revealed that intrapulmonary right-to-left shunt ratio also paralleled the extent of hypoxemia. The pathophysiology of hepatopulmonary syndrome appeared to involve a reversible intrapulmonary vascular dilatation. The perfusion lung scan could semiquantitate the severity of intrapulmonary vascular dilatation and could offer the efficient method to follow their progress. PMID:8440418

  13. Split-plot designs for robotic serial dilution assays.

    Science.gov (United States)

    Buzas, Jeffrey S; Wager, Carrie G; Lansky, David M

    2011-12-01

    This article explores effective implementation of split-plot designs in serial dilution bioassay using robots. We show that the shortest path for a robot to fill plate wells for a split-plot design is equivalent to the shortest common supersequence problem in combinatorics. We develop an algorithm for finding the shortest common supersequence, provide an R implementation, and explore the distribution of the number of steps required to implement split-plot designs for bioassay through simulation. We also show how to construct collections of split plots that can be filled in a minimal number of steps, thereby demonstrating that split-plot designs can be implemented with nearly the same effort as strip-plot designs. Finally, we provide guidelines for modeling data that result from these designs.

  14. Serial ATA眼睛(EYE)的故事

    Institute of Scientific and Technical Information of China (English)

    赵秀哲; 谢荣禧

    2004-01-01

    自2003年第二委起Intel推出支持Serial ATA(以下简称SATA)的南桥芯片(ICH 5)后,SATA接口将取代传统Parallel ATA(IDE)的态势也日渐明显(请参考表1之比较表)。而大部分的厂商在评估SATA相关chip的优劣时,往往会从Performance、Compatibility与SATA PHY的特性来观察比较,而有关SATA PHY的特性量测,最常使用的就是所谓的EYE Diaqram(眼图)特性的比较了。

  15. Assessing sleep consciousness within subjects using a serial awakening paradigm

    Directory of Open Access Journals (Sweden)

    Francesca eSiclari

    2013-08-01

    Full Text Available Dreaming - a particular form of consciousness that occurs during sleep - undergoes major changes in the course of the night. We aimed to outline state-dependent features of consciousness using a paradigm with multiple serial awakenings/questionings that allowed for within as well as between subject comparisons. Seven healthy participants who spent 44 experimental study nights in the laboratory were awakened by a computerized sound at 15-30 minute intervals, regardless of sleep stage, and questioned for the presence or absence of sleep consciousness. Recall without content (‘I was experiencing something but do not remember what’ was considered separately. Subjects had to indicate the content of the most recent conscious experience prior to the alarm sound and to estimate its duration and richness. We also assessed the degree of thinking and perceiving, self- and environment-relatedness and reflective consciousness of the experiences. Of the 778 questionings, 5% were performed during wakefulness, 2% in stage N1, 42% in N2, 33% in N3 and 17% in rapid eye movement (REM sleep. Recall with content was reported in 34% of non-REM and in 77% of REM sleep awakenings. Sleep fragmentation inherent to the study design appeared to only minimally affect the recall of conscious experiences. Each stage displayed a unique combination of characteristic features of sleep consciousness. In conclusion, our serial awakening paradigm allowed us to collect a large and representative sample of conscious experiences across states of being. It represents a time-efficient method for the study of sleep consciousness that may prove particularly advantageous when combined with techniques such as functional MRI and high-density EEG.

  16. 27 CFR 20.179 - Package identification number or serial number.

    Science.gov (United States)

    2010-04-01

    ... number or serial number. 20.179 Section 20.179 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... Package identification number or serial number. (a) Requirement. A dealer who fills packages with specially denatured spirits shall mark each package with a package identification number, in accordance...

  17. Analysis of Readex's Serial Set MARC Records: Improving the Data for the Library Catalog

    Science.gov (United States)

    Draper, Daniel; Lederer, Naomi

    2013-01-01

    Colorado State University Libraries (CSUL) purchased the digitized "United States Congressional Serial Set," 1817-1994 and "American State Papers" (1789-1838) from the Readex Division of NewsBank, Inc. and, once funds and records were available, the accompanying MARC records. The breadth of information found in the "Serial Set" is described, along…

  18. Serial cranial ultrasonography or early MRI for detecting preterm brain injury?

    NARCIS (Netherlands)

    Plaisier, Annemarie; Raets, Marlou M A; Ecury-Goossen, Ginette M; Govaert, Paul; Feijen-Roon, Monique; Reiss, Irwin K M; Smit, Liesbeth S; Lequin, Maarten H; Dudink, Jeroen

    2015-01-01

    OBJECTIVE: To investigate detection ability and feasibility of serial cranial ultrasonography (CUS) and early MRI in preterm brain injury. DESIGN: Prospective cohort study. SETTING: Level III neonatal intensive care unit. PATIENTS: 307 infants, born below 29 weeks of gestation. METHODS: Serial CUS a

  19. Visual and Phonological Similarity Effects in Verbal Immediate Serial Recall: A Test with Kanji Materials

    Science.gov (United States)

    Saito, Satoru; Logie, Robert H.; Morita, Aiko; Law, Anna

    2008-01-01

    In a series of three experiments, native speakers of Japanese performed serial ordered written recall of visually presented Japanese kanji characters that varied systematically in visual and phonological similarity. Overall effects of phonological similarity were observed for retention of serial order under silent reading in Experiments 1 and 3…

  20. The transition model test for serial dependence in mixed-effects models for binary data

    DEFF Research Database (Denmark)

    Breinegaard, Nina; Rabe-Hesketh, Sophia; Skrondal, Anders

    2016-01-01

    Generalized linear mixed models for longitudinal data assume that responses at different occasions are conditionally independent, given the random effects and covariates. Although this assumption is pivotal for consistent estimation, violation due to serial dependence is hard to assess by model...... the targeted root mean squared error of approximation (TRSMEA) as a measure of the population misfit due to serial dependence....

  1. 9 CFR 113.8 - In vitro tests for serial release.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false In vitro tests for serial release. 113.8 Section 113.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT... REQUIREMENTS Applicability § 113.8 In vitro tests for serial release. (a) Master Seed which has...

  2. Serial CT findings of cryptogenic organizing pneumonia and changes after corticosteroid therapy

    International Nuclear Information System (INIS)

    Objective: To review the serial CT findings of cryptogenic organizing pneumonia (COP) and semi-quantitatively analyze the changes after corticosteroid therapy. Methods: The clinical and radiological features of 13 patients with COP confirmed by pathology were retrospectively collected and analyzed. The lung lesions extent on CT scans was estimated using semi-quantitative method. Changes of overall disease extent were evaluated by comparing the initial CT images and the follow-up CT scans after corticosteroid therapy. Results: CT images of all cases revealed diffuse and bilateral lesions, mainly located in lower zone, distributed as predominantly subpleural and (or) along the bronchovascular bundle. The two most common manifestations of lung abnormality on initial scans were ground-glass opacity (GGO) (13 cases) and consolidation (12 cases), the average areas of which were 13% and 10% respectively. The treatment with antibiotics was ineffective. After treatment with corticosteroid, the lesions resolved completely in 2 patients; the disease was decreased in extent in 8 patients; and the lesion showed no change in extent in one patient, while the disease progressed in extent in 2 patients on follow-up CT. The most common CT findings were GGO (10 cases) and reticulation (5 cases), followed by consolidation (4 cases), the average areas of which were 19%, 2% and 1% respectively. Conclusion: The CT features of the patients with COP are characteristic. The most lesions resolved or improved after corticosteroid therapy on follow-up CT scans. The estimation of disease extent with semi-quantitative method is helpful for the clinicians to evaluate the therapeutic effect. (authors)

  3. Changing Series: Narrative Models and the Role of the Viewer in Contemporary Television Seriality

    Directory of Open Access Journals (Sweden)

    Veronica Innocenti

    2015-04-01

    Full Text Available In the past few years television serial narratives have gone through some severe changes in the way they are organized from a narrative point of view, as well as in the way they are perceived by the audiences. Our article originates from the necessity of investigating the products of this new wave of serial production, with the purpose of focusing on narrative formulas and on the relationships that serial products establish with their users. Vast serialized narratives are not just texts anymore, they have become complex universes of meaning that last for long time and that have a strong influence on the audiences. The article aims to investigate serial narratives as usable objects, that are not just seen by the public, but that are part of a complex experience. 

  4. Psychological profiling of offender characteristics from crime behaviors in serial rape offences.

    Science.gov (United States)

    Kocsis, Richard N; Cooksey, Ray W; Irwin, Harvey J

    2002-04-01

    Criminal psychological profiling has progressively been incorporated into police procedures despite a dearth of empirical research. Indeed, in the study of serial violent crimes for the purpose of psychological profiling, very few original, quantitative, academically reviewed studies actually exist. This article reports on the analysis of 62 incidents of serial sexual assault. The statistical procedure of multidimensional scaling was employed in the analysis of this data, which in turn produced a five-cluster model of serial rapist behavior. First, a central cluster of behaviors were identified that represent common behaviors to all patterns of serial rape. Second, four distinct outlying patterns were identified as demonstrating distinct offence styles, these being assigned the following descriptive labels brutality, intercourse, chaotic, and ritual. Furthermore, analysis of these patterns also identified distinct offender characteristics that allow for the use of empirically robust offender profiles in future serial rape investigations.

  5. The case of Jeffrey Dahmer: sexual serial homicide from a neuropsychiatric developmental perspective.

    Science.gov (United States)

    Silva, J Arturo; Ferrari, Michelle M; Leong, Gregory B

    2002-11-01

    Sexual serial homicidal behavior has received considerable attention during the last three decades. Substantial progress has been made in the development of methods aimed at identifying and apprehending individuals who exhibit these behaviors. In spite of these advances, the origins of sexual serial killing behavior remain for the most part unknown. In this article we propose a biopsychosocial psychiatric model for understanding the origins of sexual serial homicidal behavior from both neuropsychiatric and developmental perspectives, using the case of convicted serial killer Jeffrey Dahmer as the focal point. We propose that his homicidal behavior was intrinsically associated with autistic spectrum psychopathology, specifically Asperger's disorder. The relationship of Asperger's disorder to other psychopathology and to his homicidal behavior is explored. We discuss potential implications of the proposed model for the future study of the causes of sexual serial homicidal crime.

  6. Testing Cross-Sectional Correlation in Large Panel Data Models with Serial Correlation

    Directory of Open Access Journals (Sweden)

    Badi H. Baltagi

    2016-11-01

    Full Text Available This paper considers the problem of testing cross-sectional correlation in large panel data models with serially-correlated errors. It finds that existing tests for cross-sectional correlation encounter size distortions with serial correlation in the errors. To control the size, this paper proposes a modification of Pesaran’s Cross-sectional Dependence (CD test to account for serial correlation of an unknown form in the error term. We derive the limiting distribution of this test as N , T → ∞ . The test is distribution free and allows for unknown forms of serial correlation in the errors. Monte Carlo simulations show that the test has good size and power for large panels when serial correlation in the errors is present.

  7. IEEE 1394/firewire a low cost, high speed, digital serial bus

    Energy Technology Data Exchange (ETDEWEB)

    Gaunt, R.

    1997-05-01

    Does the world need yet another 1/0 bus standard? If you need fast and cheap serial video communication, then the answer is yes. As technology advances, so too must data transport mechanisms advance. You can`t expect RS-232 to support real-time digital video, and if you can`t afford expensive professional serial video interfaces, (such as Sony`s Serial Digital Interface), Firewire may be a good solution. IEEE 1394, or commonly known as Firewire, is a general purpose serial bus that meets many of the 1/0 needs of today`s video and multimedia developers. For those of you who only read the first paragraph, here`s Firewire in a nutshell: It provides a guaranteed transfer rate of 10OMbps or 20OMbps of digital data (such as video direct from camera to computer), over an inexpensive, non-proprietary serial bus. Here is a list of its features.

  8. Depression and pain: testing of serial multiple mediators

    Directory of Open Access Journals (Sweden)

    Wongpakaran T

    2016-07-01

    Full Text Available Tinakon Wongpakaran,1 Nahathai Wongpakaran,1 Sitthinant Tanchakvaranont,2 Putipong Bookkamana,3 Manee Pinyopornpanish,1 Kamonporn Wannarit,4 Sirina Satthapisit,5 Daochompu Nakawiro,6 Thanita Hiranyatheb,6 Kulvadee Thongpibul7 1Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Kingdom of Thailand; 2Department of Psychiatry, Queen Savang Vadhana Memorial Hospital, Chonburi, Kingdom of Thailand; 3Department of Statistics, Faculty of Science, Chiang Mai University, Chiang Mai, Kingdom of Thailand; 4Department of Psychiatry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Kingdom of Thailand; 5Department of Psychiatry, Khon Kaen Regional Hospital, Khon Kaen, Kingdom of Thailand; 6Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Kingdom of Thailand; 7Department of Psychology, Faculty of Humanities, Chiang Mai University, Chiang Mai, Kingdom of Thailand Purpose: Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders.Participants and methods: An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36, the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed.Results: Perceived stress, self-sacrificing interpersonal style, and cognitive

  9. Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation

    NARCIS (Netherlands)

    Hemels, Martin E. W.; Van Noord, Trudeke; Crijns, Harry J. G. M.; Van Veldhuisen, Dirk J.; Veeger, Nic J. G. M.; Bosker, Hans A.; Wiesfeld, Ans C. P.; Van den Berg, Maarten P.; Ranchor, Adelita V.; Van Gelder, Isabelle C.

    2006-01-01

    OBJECTIVES The VERDICT (Verapamil Versus Digoxin and Acute Versus Routine Serial Cardioversion Trial) is a prospective, randomized study to investigate whether: 1) acutely repeated serial electrical cardioversions (ECVs) after a relapse of atrial fibrillation (AF); and 2) prevention of intracellular

  10. Quantitative serial MRI of the treated fibroid uterus.

    Directory of Open Access Journals (Sweden)

    Kirsty I Munro

    Full Text Available There are no long-term medical treatments for uterine fibroids, and non-invasive biomarkers are needed to evaluate novel therapeutic interventions. The aim of this study was to determine whether serial dynamic contrast-enhanced MRI (DCE-MRI and magnetization transfer MRI (MT-MRI are able to detect changes that accompany volume reduction in patients administered GnRH analogue drugs, a treatment which is known to reduce fibroid volume and perfusion. Our secondary aim was to determine whether rapid suppression of ovarian activity by combining GnRH agonist and antagonist therapies results in faster volume reduction.Forty women were assessed for eligibility at gynaecology clinics in the region, of whom thirty premenopausal women scheduled for hysterectomy due to symptomatic fibroids were randomized to three groups, receiving (1 GnRH agonist (Goserelin, (2 GnRH agonist+GnRH antagonist (Goserelin and Cetrorelix or (3 no treatment. Patients were monitored by serial structural, DCE-MRI and MT-MRI, as well as by ultrasound and serum oestradiol concentration measurements from enrolment to hysterectomy (approximately 3 months.A volumetric treatment effect assessed by structural MRI occurred by day 14 of treatment (9% median reduction versus 9% increase in untreated women; P = 0.022 and persisted throughout. Reduced fibroid perfusion and permeability assessed by DCE-MRI occurred later and was demonstrable by 2-3 months (43% median reduction versus 20% increase respectively; P = 0.0093. There was no apparent treatment effect by MT-MRI. Effective suppression of oestradiol was associated with early volume reduction at days 14 (P = 0.041 and 28 (P = 0.0061.DCE-MRI is sensitive to the vascular changes thought to accompany successful GnRH analogue treatment of uterine fibroids and should be considered for use in future mechanism/efficacy studies of proposed fibroid drug therapies. GnRH antagonist administration does not appear to accelerate volume reduction

  11. Alexander von Humboldt und Carlos Montúfar als Reisegefährten: ein Vergleich ihrer Tagebücher zum Chimborazo-Aufstieg

    Directory of Open Access Journals (Sweden)

    Reinhard Andress

    2011-03-01

    Full Text Available ZusammenfassungAls Alexander von Humboldt im Juni 1802 von Quito aus zum Rest seiner lateinamerikanischen Forschungsreise aufbrach, begleitete ihn, abgesehen von Aimé Bonpland, Carlos Montúfar bis nach Europa zurück begleitet, u.a. auch auf beim Versuch, den Chimborazo zu ersteigen. Bis kurz vor der Stadt Cajamarca im heutigen Peru schrieb Montúfar ein relativ unbekanntes Tagebuch zur Reise. Nach einem kurzen Ausflug in das Leben von Humboldts Begleiter steht im Zentrum der weiteren Ausführungen die Frage, ob sein Tagebuch ein anderes Licht auf Humboldt und speziell auf den Aufstiegsversuch wirft. Das läuft auf einen Vergleich der Tagebücher der beiden Reisegefährten hinaus und auf den Versuch, die scheinbaren Widersprüche aufzulösen.AbstractWhen Alexander von Humboldt left Quito in June 1802 in order to undertake the rest of his Latin-American trip of exploration, he was accompanied, aside from Aimé Bonpland, by Carlos Montúfar all the way back to Europe, including the attempt to scale the Chimborazo. Up to shortly before the city of Cajamarca in today’s Peru, Montúfar wrote an relatively unknown diary account of their travels. After a brief excursion into the life of Humboldt’s companion, the question is considered whether his diary sheds a different light on Humboldt and specifically on the mountain climb. That amounts to a comparison of the diaries of the two travel companions and to an attempt to explain the apparent contradictions.ResumenCuando Alexander von Humboldt salió de Quito en junio de 1802 para continuar con el resto de su viaje de exploración por la América Latina, fue acompañado por Carlos Montúfar además de Aimé Bonpland hasta que volvieron a Europa. Este trayecto incluía la tentativa de llegar a la cima del Chimborazo. Hasta un poco antes de la cuidad de Cajamarca que está en el Perú de hoy día, Montúfar mantenía un diario relativamente no conocido del viaje. Después de una breve excursión por

  12. Optical Waveform Sampling of a 320 Gbit/s Serial Data Signal using a Hydrogenated Amorphous Silicon Waveguide

    DEFF Research Database (Denmark)

    Ji, Hua; Hu, Hao; Pu, Minhao;

    2011-01-01

    We propose using a hydrogenated amorphous silicon waveguide for ultra-high-speed serial data waveform sampling. 320 Gbit/s serial optical data sampling is experimentally demonstrated with +12 dB intrinsic four wave mixing conversion efficiency.......We propose using a hydrogenated amorphous silicon waveguide for ultra-high-speed serial data waveform sampling. 320 Gbit/s serial optical data sampling is experimentally demonstrated with +12 dB intrinsic four wave mixing conversion efficiency....

  13. High speed serial link for UA1 microprocessor network

    International Nuclear Information System (INIS)

    The UA1 data acquisition system consists of a set of distributed microprocessor units. An interprocessor link, independent of the CAMAC data readout, has been developed in order to have continuous remote control and run-time data handling, e.g. transmission of calibration programs/parameters, equipment rest/status and histogram accumulation. The data transmission system is designed to be used in a loop configuration equipped with transceivers for twisted pair cables (RS-422). As an economical system it is running as an ancillary serial loop-link between microprocessors Like Data Acquisition Crate Controllers and systems with distributed intelligence. The software driver consists of a loop-controller package, which may run in a BAMBI Computer Language environment and a fully interrupt controlled program for all other secondary stations. A special single-character mode provides a handy link for remote debugging in a pseudo-full-duplex mode. The format is based on the HDLC protocol without sequence numbering. The Chip MC-6854 from Motorola, Inc. enables an implementation with few components. (orig.)

  14. Simulation and Analysis of Uncooled Microbolometer for Serial Readout Architecture

    Directory of Open Access Journals (Sweden)

    Musaed Alhussein

    2016-01-01

    Full Text Available A detailed thermal behavior and theoretical analysis of uncooled resistive microbolometer is presented along with the proposed thermal imager simulator. An accurate model of a thermal detector is required to design a readout circuit that can compensate for the noise due to process variability and self-heating. This paper presents a realistic simulation model of microbolometer that addresses the fixed pattern noise, Johnson noise, and self-heating. Different simulations were performed to study the impact of infrared power and bias power on the performance of microbolometers. The microbolometers were biased with different bias currents along with different thermal parameters of the reference microbolometer to analyze the impact of self-heating on the thermal image. The proposed thermal imager simulator is used as a tool to visually analyze the impact of noise on the quality of a thermal image. This simulator not only helps in compensating the noise prior to the implementation in Analog Design Environment, but also can be used as a platform to explore different readout architectures. In this work, serial readout architecture was simulated with a row of blind microbolometers that served as a reference. Moreover, the algorithm for the proposed thermal imager simulator is presented.

  15. A novel inert crystal delivery medium for serial femtosecond crystallography

    Directory of Open Access Journals (Sweden)

    Chelsie E. Conrad

    2015-07-01

    Full Text Available Serial femtosecond crystallography (SFX has opened a new era in crystallography by permitting nearly damage-free, room-temperature structure determination of challenging proteins such as membrane proteins. In SFX, femtosecond X-ray free-electron laser pulses produce diffraction snapshots from nanocrystals and microcrystals delivered in a liquid jet, which leads to high protein consumption. A slow-moving stream of agarose has been developed as a new crystal delivery medium for SFX. It has low background scattering, is compatible with both soluble and membrane proteins, and can deliver the protein crystals at a wide range of temperatures down to 4°C. Using this crystal-laden agarose stream, the structure of a multi-subunit complex, phycocyanin, was solved to 2.5 Å resolution using 300 µg of microcrystals embedded into the agarose medium post-crystallization. The agarose delivery method reduces protein consumption by at least 100-fold and has the potential to be used for a diverse population of proteins, including membrane protein complexes.

  16. A novel inert crystal delivery medium for serial femtosecond crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Conrad, Chelsie E.; Basu, Shibom; James, Daniel; Wang, Dingjie; Schaffer, Alexander; Roy-Chowdhury, Shatabdi; Zatsepin, Nadia A.; Aquila, Andrew; Coe, Jesse; Gati, Cornelius; Hunter, Mark S.; Koglin, Jason E.; Kupitz, Christopher; Nelson, Garrett; Subramanian, Ganesh; White, Thomas A.; Zhao, Yun; Zook, James; Boutet, Sébastien; Cherezov, Vadim; Spence, John C. H.; Fromme, Raimund; Weierstall, Uwe; Fromme, Petra

    2015-06-30

    Serial femtosecond crystallography (SFX) has opened a new era in crystallography by permitting nearly damage-free, room-temperature structure determination of challenging proteins such as membrane proteins. In SFX, femtosecond X-ray free-electron laser pulses produce diffraction snapshots from nanocrystals and microcrystals delivered in a liquid jet, which leads to high protein consumption. A slow-moving stream of agarose has been developed as a new crystal delivery medium for SFX. It has low background scattering, is compatible with both soluble and membrane proteins, and can deliver the protein crystals at a wide range of temperatures down to 4°C. Using this crystal-laden agarose stream, the structure of a multi-subunit complex, phycocyanin, was solved to 2.5Å resolution using 300µg of microcrystals embedded into the agarose medium post-crystallization. The agarose delivery method reduces protein consumption by at least 100-fold and has the potential to be used for a diverse population of proteins, including membrane protein complexes.

  17. Serial monogamy and sex ratio bias in Nazca boobies.

    Science.gov (United States)

    Maness, Terri J; Anderson, David J

    2007-08-22

    Biased operational sex ratios (OSRs) can drive sexual selection on members of the over-represented sex via competition for mates, causing higher variance and skew in reproductive success (RS) among them if an individual's quality is a persistent characteristic. Alternatively, costs of reproduction may degrade breeding performance, creating the opportunity for members of the limiting sex to switch mates adaptively, effectively homogenizing variance and skew in RS among the sex in excess. We tested these two contrasting models in a male-biased population of the Nazca booby (Sula granti) with demonstrated costs of reproduction with data on total RS over a 14-year period. Variances and skews in RS were similar, and males changed from breeder to non-breeder more frequently than females. Under the persistent individual quality model, females should mate only with high quality males, and non-breeding males should seldom enter the breeding pool, yet 45% of non-breeding males (re)entered the breeding pool each year on average. Many Nazca booby females apparently exchange a depleted male for a new mate from the pool of current non-breeder males. Our evidence linking serial monogamy to costs of reproduction is novel and suggests selection on female mating preferences based on an interaction between at least two life-history components (OSR and reproductive effort).

  18. Bottlenecks in serial production lines: A system-theoretic approach

    Directory of Open Access Journals (Sweden)

    C.-T. Kuo

    1996-01-01

    Full Text Available In this work, a new definition of production systems bottlenecks is formulated and analyzed. Specifically, a machine is defined as the bottleneck if the sensitivity of the system's performance index to this machine's production rate in isolation is the largest. Although appealing from the systems point of view, this definition suffers a deficiency due to the fact that the sensitivities involved cannot be either measured on-line or efficiently calculated off-line. To avoid this, the paper develops a method based on indirect but real-time data. From this point of view, the main result of the work is as follows: The bottleneck machine in a serial production line can be identified by analyzing relationships between the so-called manufacturing blockage and manufacturing starvation of each machine. This leads to a simple rule for bottleneck identification. The rule requires neither the calculation of the production rate sensitivities nor the production rate itself. When the probabilities of manufacturing blockages and starvations are not available from on-line measurements, the paper presents their analytical estimates which, under certain conditions, can be used for bottleneck identification. Finally, a case study at an automotive component plant is described.

  19. Serial Analysis of Gene Expression: Applications in Human Studies

    Directory of Open Access Journals (Sweden)

    Tuteja Renu

    2004-01-01

    Full Text Available Serial analysis of gene expression (SAGE is a powerful tool, which provides quantitative and comprehensive expression profile of genes in a given cell population. It works by isolating short fragments of genetic information from the expressed genes that are present in the cell being studied. These short sequences, called SAGE tags, are linked together for efficient sequencing. The frequency of each SAGE tag in the cloned multimers directly reflects the transcript abundance. Therefore, SAGE results in an accurate picture of gene expression at both the qualitative and the quantitative levels. It does not require a hybridization probe for each transcript and allows new genes to be discovered. This technique has been applied widely in human studies and various SAGE tags/SAGE libraries have been generated from different cells/tissues such as dendritic cells, lung fibroblast cells, oocytes, thyroid tissue, B-cell lymphoma, cultured keratinocytes, muscles, brain tissues, sciatic nerve, cultured Schwann cells, cord blood-derived mast cells, retina, macula, retinal pigment epithelial cells, skin cells, and so forth. In this review we present the updated information on the applications of SAGE technology mainly to human studies.

  20. Serial femtosecond crystallography of soluble proteins in lipidic cubic phase.

    Science.gov (United States)

    Fromme, Raimund; Ishchenko, Andrii; Metz, Markus; Chowdhury, Shatabdi Roy; Basu, Shibom; Boutet, Sébastien; Fromme, Petra; White, Thomas A; Barty, Anton; Spence, John C H; Weierstall, Uwe; Liu, Wei; Cherezov, Vadim

    2015-09-01

    Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) enables high-resolution protein structure determination using micrometre-sized crystals at room temperature with minimal effects from radiation damage. SFX requires a steady supply of microcrystals intersecting the XFEL beam at random orientations. An LCP-SFX method has recently been introduced in which microcrystals of membrane proteins are grown and delivered for SFX data collection inside a gel-like membrane-mimetic matrix, known as lipidic cubic phase (LCP), using a special LCP microextrusion injector. Here, it is demonstrated that LCP can also be used as a suitable carrier medium for microcrystals of soluble proteins, enabling a dramatic reduction in the amount of crystallized protein required for data collection compared with crystals delivered by liquid injectors. High-quality LCP-SFX data sets were collected for two soluble proteins, lysozyme and phycocyanin, using less than 0.1 mg of each protein. PMID:26306196

  1. Serial femtosecond crystallography of soluble proteins in lipidic cubic phase

    Directory of Open Access Journals (Sweden)

    Raimund Fromme

    2015-09-01

    Full Text Available Serial femtosecond crystallography (SFX at X-ray free-electron lasers (XFELs enables high-resolution protein structure determination using micrometre-sized crystals at room temperature with minimal effects from radiation damage. SFX requires a steady supply of microcrystals intersecting the XFEL beam at random orientations. An LCP–SFX method has recently been introduced in which microcrystals of membrane proteins are grown and delivered for SFX data collection inside a gel-like membrane-mimetic matrix, known as lipidic cubic phase (LCP, using a special LCP microextrusion injector. Here, it is demonstrated that LCP can also be used as a suitable carrier medium for microcrystals of soluble proteins, enabling a dramatic reduction in the amount of crystallized protein required for data collection compared with crystals delivered by liquid injectors. High-quality LCP–SFX data sets were collected for two soluble proteins, lysozyme and phycocyanin, using less than 0.1 mg of each protein.

  2. Serial femtosecond crystallography of soluble proteins in lipidic cubic phase

    Energy Technology Data Exchange (ETDEWEB)

    Fromme, Raimund; Ishchenko, Andrii; Metz, Markus; Chowdhury, Shatabdi Roy; Basu, Shibom; Boutet, Sébastien; Fromme, Petra; White, Thomas A.; Barty, Anton; Spence, John C. H.; Weierstall, Uwe; Liu, Wei; Cherezov, Vadim

    2015-08-04

    Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) enables high-resolution protein structure determination using micrometre-sized crystals at room temperature with minimal effects from radiation damage. SFX requires a steady supply of microcrystals intersecting the XFEL beam at random orientations. An LCP–SFX method has recently been introduced in which microcrystals of membrane proteins are grown and delivered for SFX data collection inside a gel-like membrane-mimetic matrix, known as lipidic cubic phase (LCP), using a special LCP microextrusion injector. Here, it is demonstrated that LCP can also be used as a suitable carrier medium for microcrystals of soluble proteins, enabling a dramatic reduction in the amount of crystallized protein required for data collection compared with crystals delivered by liquid injectors. High-quality LCP–SFX data sets were collected for two soluble proteins, lysozyme and phycocyanin, using less than 0.1 mg of each protein.

  3. Serial Myocardial Imaging after a Single Dose of Thallium-201

    Directory of Open Access Journals (Sweden)

    Takahiko Kamata

    2014-10-01

    Full Text Available Although thallium-201 exercise scintigraphy has been established for the detection of myocardial ischemia and viability, little is known regarding the myocardial thallium-201 kinetics during angioplasty. Herein, we report a 77-year old man with angina pectoris, in whom serial myocardial imaging after a single dose of thallium-201 was helpful in identifying not only the culprit lesion and myocardial viability, but also the dynamic changes in myocardial perfusion during angioplasty. Thallium-201 images after exercise showed a perfusion defect in the inferior wall, with a trivial redistribution 3 hours after the exercise and a marked improvement 24 hours later. Coronary angiography, performed 27 hours after exercise scintigraphy, showed severe stenosis in the right coronary artery. Guidewire crossing of the lesion interrupted the antegrade flow, which was restored after balloon dilation and stent implantation. Thallium-201 images, 2 hours after angioplasty (i.e., 30 hours after exercise, showed a decreased tracer uptake in the inferior wall, which improved the next day (i.e., 48 hours after exercise. Cardiac biomarkers were negative in the clinical course.

  4. Prophetic Visions, Quality Serials: Twin Peaks’ new mode of storytelling

    Directory of Open Access Journals (Sweden)

    Mikhail L. Skoptsov

    2015-05-01

    Full Text Available Following the April 1990 debut of Twin Peaks on ABC, the vision - a sequence of images that relates information of the narrative future or past – has become a staple of numerous network, basic cable and premium cable serials, including Buffy the Vampire Slayer (WB, Battlestar Galactica (SyFy and Game of Thrones (HBO. This paper argues that Peaks in effect had introduced a mode of storytelling called “visio-narrative,” which draws on ancient epic poetry by focusing on main characters that receive knowledge from enigmatic, god-like figures that control his world. Their visions disrupt linear storytelling, allowing a series to embrace the formal aspects of the medium and create the impression that its disparate episodes constitute a singular whole. This helps them qualify as ‘quality TV’, while disguising instances of authorial manipulation evident within the texts as products of divine internal causality.As a result, all narrative events, no matter how coincidental or inconsequential, become part of a grand design. Close examination of Twin Peaks and Carnivàle will demonstrate how the mode operates, why it is popular among modern storytellers and how it can elevate a show’s cultural status.

  5. Serial pharmacological prescribing practices for tic management in Tourette syndrome.

    Science.gov (United States)

    Farag, Mena; Stern, Jeremy S; Simmons, Helen; Robertson, Mary M

    2015-11-01

    Pharmacological treatments for Tourette syndrome (TS) vary in efficacy between different patients. The evidence base is limited as even high quality controlled studies tend to be of relatively short duration which may lose relevance in clinical usage. Patients are frequently treated with serial agents in the search for efficacy and tolerability. The success of this strategy has not been previously documented. We examined 400 consecutive TS patients seen over a 10-year period, some with a longer prior history in other clinics; 255/400 (64%) were prescribed medication. We present this heterogeneous cohort in terms of the number of drugs they had tried, and as a proxy measure of some benefit of the last drug used, whether it had been prescribed under our supervision for ≥ 5 months. The most commonly prescribed medications were aripiprazole (64%), clonidine (40%), risperidone (30%) and sulpiride (29%) with changes in prescribing practises over the period examined. The number of different drugs tried were one (n = 155), two (n = 69), three (n = 36), four (n = 14), five (n = 15), six (n = 5), seven (n = 2) and eight (n = 1). The data illustrate the difficulty in drug treatment of tics and suggest that even after trials of several agents there is potential benefit in trying further options.

  6. Implications of the focal beam profile in serial femtosecond crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Galli, Lorenzo [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Chapman, Henry N. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Metcalf, Peter [Univ. of Auckland (New Zealand)

    2015-05-12

    The photon density profile of an X-ray free-electron laser (XFEL) beam at the focal position is a critical parameter for serial femtosecond crystallography (SFX), but is difficult to measure because of the destructive power of the beam. A novel high intensity radiation induced phasing method (HIRIP) has been proposed as a general experimental approach for protein structure determination, but has proved to be sensitive to variations of the X-ray intensity, with uniform incident fluence desired for best performance. Here we show that experimental SFX data collected at the nano-focus chamber of the Coherent X-ray Imaging end-station at the Linac Coherent Light Source using crystals with a limited size distribution suggests an average profile of the X-ray beam that has a large variation of intensity. We propose a new method to improve the quality of high fluence data for HI-RIP, by identifying and removing diffraction patterns from crystals exposed to the low intensity region of the beam. The method requires crystals of average size comparable to the width of the focal spot.

  7. High speed serial link for UA1 microprocessor network

    CERN Document Server

    Cittolin, Sergio; Zurfluh, E

    1981-01-01

    The UA1 data acquisition system consists of a set of distributed microprocessor units. An interprocessor link, independent of the CAMAC data readout, has been developed in order to have continuous remote control and run-time data handling, e.g. transmission of calibration programs/parameters, equipment test/status and histogram accumulation. The data transmission system is designed to be used in a loop configuration equipped with transceivers for twisted pair cables (RS-422). As an economical system, it is running as an ancillary serial loop-link between microprocessors, like data acquisition crate controllers and systems with distributed intelligence. The software driver consists of a loop-controller package, which may run in a BAMBI computer language environment and a fully interrupt controlled program for all other secondary stations. A special single-character mode provides a handy link for remote debugging in a pseudo-full-duplex mode. The format is based on the HDLC protocol without sequence numbering. ...

  8. High speed serial link for UA1 microprocessor network

    CERN Document Server

    Cittolin, S; Zurfluh, E

    1981-01-01

    The UA1 data acquisition system consists of a set of distributed microprocessor units. An interprocessor link, independent of the CAMAC data readout, has been developed in order to have continuous remote control and run-time data handling, e.g. transmission of calibration programs/parameters, equipment test/status and histogram accumulation. The data transmission system is designed to be used in a loop configuration equipped with transceivers for twisted pair cables (RS-422). As an economical system, it is running as an ancillary serial loop-link between microprocessors, like Data Acquisition Crate Controllers and systems with distributed intelligence. The software driver consists of a loop-controller package, which may run in a BAMBI Computer Language environment and a fully interrupt controlled program for all other secondary stations. A special single-character mode provides a handy link for remote debugging in a pseudo-full-duplex mode. The format is based on the HDLC protocol without sequence numbering. ...

  9. Realisation of serial powering of ATLAS pixel modules

    CERN Document Server

    Stockmanns, Tobias; Fischer, P; Hügging, Fabian Georg; Peric, Ivan; Runólfsson, Ogmundur; Wermes, Norbert

    2004-01-01

    Modern hybrid pixel detectors as they will be used for the next generation of high energy collider experiments like LHC avail deep sub micron technology for the readout electronics. To operate chips in this technology low supply voltages of 2.0 V to 2.5 V and high currents to achieve the desired performance are needed. Due to the long and low mass supply cables this high current leads to a significant voltage drop so that voltage fluctuations at the chip result, when the supply current changes. Therefore the parallel connection of the readout electronics with the power supplies imposes severe constraints on a detector with respect to voltage fluctuations and cable mass. To bypass this problem a new concept of serially connecting modules in a supply chain was developed. The basic idea of the concept, the potential risk and ways to minimize these risks are presented. In addition, studies of the implementation of this technology as an alternative for a possible upgrade of the ATLAS pixel detector are shown. In p...

  10. Serial DNA immobilization in micro- and extended nanospace channels.

    Science.gov (United States)

    Renberg, Björn; Sato, Kae; Mawatari, Kazuma; Idota, Naokazu; Tsukahara, Takehiko; Kitamori, Takehiko

    2009-06-01

    That focused arrays, even with a small set of ligands, provide more data than single point experiments is well established in the DNA microarray research field, but microarray technology has yet to be transferred to fused silica microchips. Fused silica microchips have several attractive features such as stability to pressure, solvents, acids and bases, and can be fabricated with minute dimensions, making them good candidates for nanofluidic research. However, due to harsh bonding conditions, DNA ligands must be immobilized after fabrication, thus preventing standard microarray spotting techniques from being used. In this paper, we provide tools for serial DNA immobilization in fused silica microchips using UV. We report the synthesis of a new UV-linker which was used to covalently couple functional DNA oligos to the inside of channels in fused silica microchips. With some simple modifications to our mask aligner, we were able to transfer OHP mask patterns, which allows the creation of basically any pattern in the channels. The functionality of the oligos was measured through the binding of fluorophore-labeled complementary target oligos. We examined parameters influencing DNA immobilization, and carry-over between spots after consecutive immobilizations inside the same channel. We also report the first successful multiple immobilizations of functional DNA oligos inside single channels of extended nanospace depth (460 nm). PMID:19458857

  11. Natural born killers?: the development of the sexually sadistic serial killer.

    Science.gov (United States)

    Johnson, B R; Becker, J V

    1997-01-01

    Today's society seems enthralled with serial killers in the news and the media. Forensic psychiatrists often interview serial killers after they have been caught. There are retrospective studies and case reports of individuals who have committed sexually sadistic serial murders. However, there exists a dearth of case reports on adolescents who have expressed serious fantasies about becoming serial killer prior to actualizing their fantasy. This article presents nine clinical cases of 14- to 18-year-olds who have clinically significant fantasies of becoming a serial killer. Similarities exist in these adolescent cases when compared with retrospective studies and case reports of serial killers on the role of sexually sadistic fantasies and actual killings. Since it has been established that sexual paraphilias may develop at a young age, one can surmise that sadistic paraphilias may also develop in some adolescents. The question is posed, can we predict which of these adolescents may go on to actually become serial killers? This article focuses on how the sexually sadistic fantasy can eventually be acted out and possible motives for the act to be repeated multiple times. Finally, recommendations are made about assessing and treating a youngster who expresses violent sexually sadistic killing fantasies so that attempts can be made to interrupt the progression to actual killing.

  12. Uncovering the genetic basis of attenuation in Marek’s disease virus

    Science.gov (United States)

    While in vitro serial passage of Marek’s disease virus (MDV) is a proven method to attenuate MDV strains, the underlying genetic changes responsible for attenuation remains unknown. To identify candidate genes and mutations, a virulent MDV generated from an Md5-containing BAC clone was serially pass...

  13. From Outer Space to the Circus Tent. Science Fiction and the Problems of ’68 in Alexander Kluge’s »Die Ungläubige«

    Directory of Open Access Journals (Sweden)

    Kirkland A. Fulk

    2013-11-01

    Full Text Available This paper explores Alexander Kluge’s forgotten work of science fiction Die Ungläubige , Kluge’s literary addendum to Die Artisten in der Zirkuskuppel: ratlos , and places it against the background of the aesthetic debates of 1968 and Kluge’s larger canon. Why did Kluge turn to science fiction at this particular time? How does this genre interrogate, expand on, or even challenge our understanding of Kluge and his aesthetic project, which in many ways cannot be thought apart from this pivotal period in German post-war history? Kluge’s text is at once a sharp critique of capitalist structures and a critical representation of utopian visions of the future, making the work an important piece of aesthetic, social and political commentary.

  14. Borg Alexander, A comparative glossary of Cypriot Maronite Arabic (Arabic-English), with an Introductary Essay, Brill, Leiden / Boston, 2004, pp. IX-XXVIII + 486 p.

    OpenAIRE

    Arlette Roth

    2006-01-01

    Dans cet ouvrage Alexander Borg parachève un ensemble de travaux qu’il a consacrés au cours des vingt dernières années à une variété d’arabe proche-oriental implantée en Chypre depuis plus d’un millénaire. Cette variété a la particularité de fonctionner à l’écart de toute influence de l’arabe écrit et sans interférences avec d’autres variétés d’arabe dialectal, ce qui lui donne, aux yeux de l’auteur, le statut d’objet scientifique idéal en matière de dialectologie arabe. L’arabe chypriote a s...

  15. [Researchers training in the context of the collaborative projects: experiences of Instituto de Medicina Tropical "Alexander von Humbolt", Universidad Peruana Cayetano Heredia].

    Science.gov (United States)

    Gotuzzo, Eduardo; González, Elsa; Verdonck, Kristien

    2010-09-01

    Research is a main element for human and social development. Under this point of view, it involves particular challenges and opportunities for the so-called "developing countries". An approach for those challenges and opportunities comes from the analysis of two interrelated activities; the training of new researchers and the research development with institutions or researchers which are external to the institution ("collaborative research"). Both activities are essential for the consolidation, widening and updating of the institutional capabilities for scientific production. We present here the experiences of the Instituto de Medicina Tropical "Alexander von Humboldt" of the Universidad Peruana Cayetano Heredia, in relation to the training of new researchers, we discuss the four elements we consider key for this process; the promotion of stimulating environments for research, the proactive identification of fellows, the complementary advice and networks consolidation; and we analyze three successful models of international collaboration for the training of new researchers under different institutional approaches.

  16. Major mutation events in structural genes of peste des petits ruminants virus through serial passages in vitro.

    Science.gov (United States)

    Wu, Xiaodong; Liu, Fuxiao; Li, Lin; Zou, Yanli; Liu, Shan; Wang, Zhiliang

    2016-06-01

    Peste des petits ruminants (PPR) is an highly contagious disease of small ruminants, and caused by peste des petits ruminants virus (PPRV), a member of the genus Morbillivirus in the family Paramyxoviridae. The first outbreak of PPR in China was officially reported in July 2007, when a PPRV strain was successfully isolated from a sick goat in Tibet, followed by sequencing at a full-genome level (China/Tibet/Geg/07-30, GenBank: FJ905304.1). To date, this isolate has been virulently attenuated by more than 90 serial passages in Vero-Dog-SLAM cells at our laboratory. In this study, a total of nine strains by serial passages (namely the 10th, 20th, 30th, 40th, 50th, 60th, 70th, 80th, and 90th passages) were chosen for sequencing of six structural genes in PPRV. The sequence analysis showed that mutation rates in all viral genes were relatively low, and only a few identical mutations within certain genes were stably maintained after an earlier passage, perhaps indicating a predominance of mutants after such a passage. PMID:26995222

  17. Serial measurements of cardiac biomarkers in patients after allogeneic hematopoietic stem cell transplantation

    Directory of Open Access Journals (Sweden)

    Roziakova Lubica

    2012-02-01

    Full Text Available Abstract Background Previous therapy with anthracyclines (ANT and conditioning regimen followed by hematopoietic stem cell transplantation (HSCT represents a high risk for development of cardiotoxicity. The aim of this study was to assess subclinical myocardial damage after HSCT using echocardiography and cardiac biomarkers - high sensitive cardiac troponin T (hs-cTnT and N-terminal pro-B-type natriuretic peptide (NT-proBNP and to identify patients at risk of developing clinical cardiotoxicity. Patients and methods Thirty-seven patients who were treated with allogeneic HSCT for hematologic diseases at median age of 28 years at time of HSCT were studied. Conditioning regimen included either chemotherapy without total body irradiation (TBI or combination of chemotherapy with TBI. Twenty-nine (78,3% patients were pretreated with ANT therapy. Cardiac biomarkers were serially measured before conditioning regimen and at days 1, 14 and 30 after HSCT. Cardiac systolic and diastolic functions were assessed before conditioning regimen and 1 month after HSCT by echocardiography. Results The changes in plasma NT-proBNP and hs-cTnT levels during the 30 days following the HSCT were statistically significant (P P Conclusions Elevations in both cardiac biomarkers were found before clinical signs of cardiotoxicity developed. Persistent elevations in NT-pro-BNP and hs-cTnT concentrations simultaneously for a period exceeding 14 days might be used for identification of patients at risk of developing cardiotoxicity and requiring further cardiological follow up.

  18. Serial analysis of gene expression (SAGE in bovine trypanotolerance: preliminary results

    Directory of Open Access Journals (Sweden)

    David Berthier

    2003-06-01

    Full Text Available Abstract In Africa, trypanosomosis is a tsetse-transmitted disease which represents the most important constraint to livestock production. Several indigenous West African taurine (Bos taurus breeds, such as the Longhorn (N'Dama cattle are well known to control trypanosome infections. This genetic ability named "trypanotolerance" results from various biological mechanisms under multigenic control. The methodologies used so far have not succeeded in identifying the complete pool of genes involved in trypanotolerance. New post genomic biotechnologies such as transcriptome analyses are efficient in characterising the pool of genes involved in the expression of specific biological functions. We used the serial analysis of gene expression (SAGE technique to construct, from Peripheral Blood Mononuclear Cells of an N'Dama cow, 2 total mRNA transcript libraries, at day 0 of a Trypanosoma congolense experimental infection and at day 10 post-infection, corresponding to the peak of parasitaemia. Bioinformatic comparisons in the bovine genomic databases allowed the identification of 187 up- and down- regulated genes, EST and unknown functional genes. Identification of the genes involved in trypanotolerance will allow to set up specific microarray sets for further metabolic and pharmacological studies and to design field marker-assisted selection by introgression programmes.

  19. Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient.

    Science.gov (United States)

    Dazert, Eva; Colombi, Marco; Boldanova, Tujana; Moes, Suzette; Adametz, David; Quagliata, Luca; Roth, Volker; Terracciano, Luigi; Heim, Markus H; Jenoe, Paul; Hall, Michael N

    2016-02-01

    Compensatory signaling pathways in tumors confer resistance to targeted therapy, but the pathways and their mechanisms of activation remain largely unknown. We describe a procedure for quantitative proteomics and phosphoproteomics on snap-frozen biopsies of hepatocellular carcinoma (HCC) and matched nontumor liver tissue. We applied this procedure to monitor signaling pathways in serial biopsies taken from an HCC patient before and during treatment with the multikinase inhibitor sorafenib. At diagnosis, the patient had an advanced HCC. At the time of the second biopsy, abdominal imaging revealed progressive disease despite sorafenib treatment. Sorafenib was confirmed to inhibit MAPK signaling in the tumor, as measured by reduced ribosomal protein S6 kinase phosphorylation. Hierarchical clustering and enrichment analysis revealed pathways broadly implicated in tumor progression and resistance, such as epithelial-to-mesenchymal transition and cell adhesion pathways. Thus, we describe a protocol for quantitative analysis of oncogenic pathways in HCC biopsies and obtained first insights into the effect of sorafenib in vivo. This protocol will allow elucidation of mechanisms of resistance and enable precision medicine. PMID:26787912

  20. Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient

    Science.gov (United States)

    Dazert, Eva; Colombi, Marco; Boldanova, Tujana; Moes, Suzette; Adametz, David; Quagliata, Luca; Roth, Volker; Terracciano, Luigi; Heim, Markus H.; Jenoe, Paul; Hall, Michael N.

    2016-01-01

    Compensatory signaling pathways in tumors confer resistance to targeted therapy, but the pathways and their mechanisms of activation remain largely unknown. We describe a procedure for quantitative proteomics and phosphoproteomics on snap-frozen biopsies of hepatocellular carcinoma (HCC) and matched nontumor liver tissue. We applied this procedure to monitor signaling pathways in serial biopsies taken from an HCC patient before and during treatment with the multikinase inhibitor sorafenib. At diagnosis, the patient had an advanced HCC. At the time of the second biopsy, abdominal imaging revealed progressive disease despite sorafenib treatment. Sorafenib was confirmed to inhibit MAPK signaling in the tumor, as measured by reduced ribosomal protein S6 kinase phosphorylation. Hierarchical clustering and enrichment analysis revealed pathways broadly implicated in tumor progression and resistance, such as epithelial-to-mesenchymal transition and cell adhesion pathways. Thus, we describe a protocol for quantitative analysis of oncogenic pathways in HCC biopsies and obtained first insights into the effect of sorafenib in vivo. This protocol will allow elucidation of mechanisms of resistance and enable precision medicine. PMID:26787912

  1. Serial MRI and MRS studies with unusual findings in Rasmussen's encephalitis

    Energy Technology Data Exchange (ETDEWEB)

    Tuerkdogan-Soezueer, D. [Department of Pediatric Neurology, Institute of Neurological Sciences, Marmara University, Istanbul (Turkey); Oezek, M.M.; Pamir, M.N. [Department of Neurosurgery, Institute of Neurological Sciences, Marmara University, Istanbul (Turkey); Sav, A. [Department of Pathology, Institute of Neurological Sciences, Marmara University, Istanbul (Turkey); Dincer, A. [Radyomar MR Center, Istanbul (Turkey)

    2000-06-01

    Rasmussen's syndrome is characterized by intractable seizures and progressive neuropsychiatric deterioration secondary to unilateral cortical inflammation and tissue destruction. Diagnosis of Rasmussen's syndrome in the early phase depends mainly on the clinical features. Neuroimaging and histopathologic examinations may not be specific during this period. We report a case of Rasmussen's syndrome followed by serial MRI and magnetic resonance spectroscopy (MRS) studies over a 3- to 16-month period. A healthy 6-year-old boy presented with focal motor seizures. An MRI study demonstrated prominent enlargement and T2 hyperintensity of the left mesial temporal lobe and perisylvian region. This early finding evolved to volume loss and later progressive atrophy of the ipsilateral hemisphere when epilepsia partialis continua occurred. Being aware of those early MRI features in a patient with increasing frequency of focal motor seizures should suggest Rasmussen's syndrome. In addition, we found prominently increased myoinositol concentration in atrophic cortex which might reflect increased gliosis in the late period of the disease. (orig.)

  2. Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset.

    Science.gov (United States)

    Blyuss, Oleg; Gentry-Maharaj, Alex; Fourkala, Evangelia-Orania; Ryan, Andy; Zaikin, Alexey; Menon, Usha; Jacobs, Ian; Timms, John F

    2015-01-01

    Early detection of ovarian cancer through screening may have impact on mortality from the disease. Approaches based on CA125 cut-off have not been effective. Longitudinal algorithms such as the Risk of Ovarian Cancer Algorithm (ROCA) to interpret CA125 have been shown to have higher sensitivity and specificity than a single cut-off. The aim of this study was to investigate whether other ovarian cancer-related biomarkers, Human Epididymis 4 (HE4), glycodelin, mesothelin, matrix metalloproteinase 7 (MMP7), and cytokeratin 19 fragment (CYFRA 21-1), could improve the performance of CA125 in detecting ovarian cancer earlier. Serum samples (single and serial) predating diagnosis from 47 women taking part in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) who went on to develop primary invasive ovarian, fallopian tube, or peritoneal cancer (index cancer) (170 samples) and 179 matched controls (893 samples) were included in the study. A multiplex immunobased assay platform (Becton Dickinson) allowing simultaneous measurement of the six serum markers was used. The area under the ROC curve for the panel of three biomarkers (CA125, HE4, and glycodelin) was higher than for CA125 alone for all analysed time groups, indicating that these markers can improve on sensitivity of CA125 alone for ovarian cancer detection. PMID:26819954

  3. Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset

    Directory of Open Access Journals (Sweden)

    Oleg Blyuss

    2015-01-01

    Full Text Available Early detection of ovarian cancer through screening may have impact on mortality from the disease. Approaches based on CA125 cut-off have not been effective. Longitudinal algorithms such as the Risk of Ovarian Cancer Algorithm (ROCA to interpret CA125 have been shown to have higher sensitivity and specificity than a single cut-off. The aim of this study was to investigate whether other ovarian cancer-related biomarkers, Human Epididymis 4 (HE4, glycodelin, mesothelin, matrix metalloproteinase 7 (MMP7, and cytokeratin 19 fragment (CYFRA 21-1, could improve the performance of CA125 in detecting ovarian cancer earlier. Serum samples (single and serial predating diagnosis from 47 women taking part in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS who went on to develop primary invasive ovarian, fallopian tube, or peritoneal cancer (index cancer (170 samples and 179 matched controls (893 samples were included in the study. A multiplex immunobased assay platform (Becton Dickinson allowing simultaneous measurement of the six serum markers was used. The area under the ROC curve for the panel of three biomarkers (CA125, HE4, and glycodelin was higher than for CA125 alone for all analysed time groups, indicating that these markers can improve on sensitivity of CA125 alone for ovarian cancer detection.

  4. Non-Euclidean Space, Movement and Astronomy in Modern Art: Alexander Calder’s Mobiles and Ben Nicholson’s Reliefs

    Directory of Open Access Journals (Sweden)

    Malloy Vanja

    2013-09-01

    Full Text Available John Keats once wrote that ‘there is no such thing as time and space’ rather, believing that time and space are mental constructs that are subject to a variety of forms and as diverse as the human mind. In the 1920s through the 1930s, modern physics in many ways supported this idea through the various philosophical writings on the Theory of General Relativity to the masses by scientists such as Arthur Eddington and Albert Einstein. These new concepts of modern physics fundamentally changed our understanding of time and space and had substantial philosophical implications, which were absorbed by modern artists resulting in the 1936 Dimensionist Manifesto. Seeking to internalize the developments of modern science within modern art, this manifesto was widely endorsed by the most prominent figures of the avant-garde such as Marcel Duchamp, Jean Arp, Naum Gabo, Joan Miró, László Moholy-Nagy, Wassily Kandinsky and Alexander Calder. Of particular interest to this manifesto was the new concept of the fourth-dimension, which in many ways revolutionized the arts. Importantly, its interpretation varied widely in the artistic community, ranging from a purely physical four-dimensional space, to a kinetic concept of space in which space and time are linked, to a metaphysical interest in a space that exists beyond the material realm. The impact of modern science and astronomy on avant-garde art is currently a bourgeoning area of research with considerable implications to our rethinking of substantial artistic figures of this era. Through a case study of Alexander Calder’s Mobiles and Ben Nicholson’s Reliefs, this paper explores how these artworks were informed by an interest in modern science.

  5. Destructive hostility: the Jeffrey Dahmer case. A psychiatric and forensic study of a serial killer.

    Science.gov (United States)

    Jentzen, J; Palermo, G; Johnson, L T; Ho, K C; Stormo, K A; Teggatz, J

    1994-12-01

    We were involved as forensic experts in the case of the serial killer Jeffrey Dahmer. We discuss the scene and victim autopsy findings, with a brief consideration of the basic emotion of hostility. These findings support the thesis that at the basis of this serial killer's behavior were primary unconscious feelings of hate that he had channeled into a sadistic programmed destruction of 17 young men. The interview of the serial killer, the photographic scene documentation, and the autopsy findings stress the ambivalent homosexuality of the killer, his sexual sadism, his obsessive fetishism, and his possible cannibalism and necrophilia.

  6. A 16:1 serializer ASIC for data transmission at 5 Gbps

    Science.gov (United States)

    Gong, D.

    2010-12-01

    A high speed, low power 16:1 serializer has been developed with a commercial 0.25 μm silicon-on-sapphire CMOS technology. The serializer operates from 4.0 to 5.7 Gbps. The total jitter is 62 ps and the eye opening of the bathtub curve is 122 ps at bit error rate of 10-12 at 5 Gbps. Power consumption is 463 mW at 5 Gbps. A proton beam test indicates the serializer is suitable for applications in high energy physics experiments.

  7. A 16:1 Serializer ASIC for Data Transmission at 5 Gbps

    CERN Document Server

    Gong, D; The ATLAS collaboration

    2010-01-01

    A high speed, low power 16:1 serializer has been developed with a commercial 0.25 μm silicon-on-sapphire CMOS technology. The serializer operates from 4.0 to 5.7 Gbps. Total jitter is 62 ps and the eye openning of the bathtub curve is 122 ps at bit rate error of 10-12 at 5 Gbps. Power consumption is 463 mW at 5 Gbps. A proton beam test indicates the serializer is suitable for applications in high energy physics experiments.

  8. A 16:1 serializer ASIC for data transmission at 5 Gbps

    Energy Technology Data Exchange (ETDEWEB)

    Gong, D, E-mail: dtgong@physics.smu.ed [Southern Methodist University, Dallas, Texas 75275 (United States)

    2010-12-15

    A high speed, low power 16:1 serializer has been developed with a commercial 0.25 {mu}m silicon-on-sapphire CMOS technology. The serializer operates from 4.0 to 5.7 Gbps. The total jitter is 62 ps and the eye opening of the bathtub curve is 122 ps at bit error rate of 10{sup -12} at 5 Gbps. Power consumption is 463 mW at 5 Gbps. A proton beam test indicates the serializer is suitable for applications in high energy physics experiments.

  9. A 16:1 serializer ASIC for data transmission at 5 Gbps

    International Nuclear Information System (INIS)

    A high speed, low power 16:1 serializer has been developed with a commercial 0.25 μm silicon-on-sapphire CMOS technology. The serializer operates from 4.0 to 5.7 Gbps. The total jitter is 62 ps and the eye opening of the bathtub curve is 122 ps at bit error rate of 10-12 at 5 Gbps. Power consumption is 463 mW at 5 Gbps. A proton beam test indicates the serializer is suitable for applications in high energy physics experiments.

  10. E-serials cataloging access to continuing and integrating resources via the catalog and the web

    CERN Document Server

    Cole, Jim

    2014-01-01

    This comprehensive guide examines the state of electronic serials cataloging with special attention paid to online capacities. E-Serials Cataloging: Access to Continuing and Integrating Resources via the Catalog and the Web presents a review of the e-serials cataloging methods of the 1990s and discusses the international standards (ISSN, ISBD[ER], AACR2) that are applicable. It puts the concept of online accessibility into historical perspective and offers a look at current applications to consider. Practicing librarians, catalogers and administrators of technical services, cataloging and serv

  11. HDL Design for 1 Zetta Bits Per Second (1 Zbps Multichannel 64:1 LVDS Data Serializer & De-Serializer ASIC Array Card Design for 6th Sense and Future Ultra High Wireless and Mobile Communication Protocol Cards

    Directory of Open Access Journals (Sweden)

    P. N. V. M SASTRY

    2015-01-01

    Full Text Available The Aim is to HDL Design & Implementation for Exa Bit Rate Multichannel 64:1 LVDS Data Serializer & De-Serializer ASIC Array Card for Ultra High Speed Wireless Communication Products like Network On Chip Routers, Data Bus Communication Interface Applications, Cloud Computing Networks , Zetta bit Ethernet at Zetta Bit Rate Of Data Transfer Speed. Basically This Serializer Array Converts 64 bit parallel Data Array in to Serial Array Form on Transmitter Side and Transmission Done through High Speed Wireless Serial Communication Link and also Converts this Same Serial Array Data into Parallel Data Array on the Receiver Side by De-Serializer Array ASIC without any noise, also measure Very High Compressed Jitter Tolerance & Eye Diagram, Bit Error Rate through Analyzer. This LVDS Data SER-De-SER mainly used in High Speed Bus Communication Protocol Transceivers, Interface FPGA Add On Cards. The Process Of Design is Implemented through Verilog HDL / VHDL, Programming & Debugging Done Latest FPGA Board.

  12. Room-temperature macromolecular serial crystallography using synchrotron radiation.

    Science.gov (United States)

    Stellato, Francesco; Oberthür, Dominik; Liang, Mengning; Bean, Richard; Gati, Cornelius; Yefanov, Oleksandr; Barty, Anton; Burkhardt, Anja; Fischer, Pontus; Galli, Lorenzo; Kirian, Richard A; Meyer, Jan; Panneerselvam, Saravanan; Yoon, Chun Hong; Chervinskii, Fedor; Speller, Emily; White, Thomas A; Betzel, Christian; Meents, Alke; Chapman, Henry N

    2014-07-01

    A new approach for collecting data from many hundreds of thousands of microcrystals using X-ray pulses from a free-electron laser has recently been developed. Referred to as serial crystallography, diffraction patterns are recorded at a constant rate as a suspension of protein crystals flows across the path of an X-ray beam. Events that by chance contain single-crystal diffraction patterns are retained, then indexed and merged to form a three-dimensional set of reflection intensities for structure determination. This approach relies upon several innovations: an intense X-ray beam; a fast detector system; a means to rapidly flow a suspension of crystals across the X-ray beam; and the computational infrastructure to process the large volume of data. Originally conceived for radiation-damage-free measurements with ultrafast X-ray pulses, the same methods can be employed with synchrotron radiation. As in powder diffraction, the averaging of thousands of observations per Bragg peak may improve the ratio of signal to noise of low-dose exposures. Here, it is shown that this paradigm can be implemented for room-temperature data collection using synchrotron radiation and exposure times of less than 3 ms. Using lysozyme microcrystals as a model system, over 40 000 single-crystal diffraction patterns were obtained and merged to produce a structural model that could be refined to 2.1 Å resolution. The resulting electron density is in excellent agreement with that obtained using standard X-ray data collection techniques. With further improvements the method is well suited for even shorter exposures at future and upgraded synchrotron radiation facilities that may deliver beams with 1000 times higher brightness than they currently produce. PMID:25075341

  13. Room-temperature macromolecular serial crystallography using synchrotron radiation

    Directory of Open Access Journals (Sweden)

    Francesco Stellato

    2014-07-01

    Full Text Available A new approach for collecting data from many hundreds of thousands of microcrystals using X-ray pulses from a free-electron laser has recently been developed. Referred to as serial crystallography, diffraction patterns are recorded at a constant rate as a suspension of protein crystals flows across the path of an X-ray beam. Events that by chance contain single-crystal diffraction patterns are retained, then indexed and merged to form a three-dimensional set of reflection intensities for structure determination. This approach relies upon several innovations: an intense X-ray beam; a fast detector system; a means to rapidly flow a suspension of crystals across the X-ray beam; and the computational infrastructure to process the large volume of data. Originally conceived for radiation-damage-free measurements with ultrafast X-ray pulses, the same methods can be employed with synchrotron radiation. As in powder diffraction, the averaging of thousands of observations per Bragg peak may improve the ratio of signal to noise of low-dose exposures. Here, it is shown that this paradigm can be implemented for room-temperature data collection using synchrotron radiation and exposure times of less than 3 ms. Using lysozyme microcrystals as a model system, over 40 000 single-crystal diffraction patterns were obtained and merged to produce a structural model that could be refined to 2.1 Å resolution. The resulting electron density is in excellent agreement with that obtained using standard X-ray data collection techniques. With further improvements the method is well suited for even shorter exposures at future and upgraded synchrotron radiation facilities that may deliver beams with 1000 times higher brightness than they currently produce.

  14. Does registration of serial MRI improve diagnosis of dementia?

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, Josephine; Kennedy, Jonathan; Barker, Suzie; Lehmann, Manja; Nordstrom, R.C.; Smith, Joseph R.; Rossor, Martin N.; Fox, Nick C. [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); Mitchell, L.A. [Austin Health, Radiology Department, Heidelberg (Australia); Melbourne University, Radiology Department, Melbourne (Australia); Bastos-Leite, Antonio J. [University of Oporto, Department of Medical Imaging, Faculty of Medicine, Oporto (Portugal); National Hospital for Neurology and Neurosurgery, Lysholm Department of Neuroradiology, London (United Kingdom); Frost, Chris [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); London School of Hygiene and Tropical Medicine, Department of Medical Statistics, London (United Kingdom); Garde, Ellen [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); Copenhagen University Hospital Hvidovre, Danish Research Centre for Magnetic Resonance, Hvidovre (Denmark)

    2010-11-15

    We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia. One hundred twenty subjects with clinical follow-up of at least 1 year with two scans were selected from a cognitive disorders clinic. Scans were reviewed as a single first scan (method A), two unregistered scans presented side-by-side (method B) and a registered pair (method C). Scans were presented to two neuroradiologists and a clinician together with approximate scan interval (if applicable) and age. Raters decided on a main and subtype diagnosis. There was no evidence that differences between methods (expressed as relative odds of a correct response) differed between reviewers (p = 0.17 for degenerative condition or not, p = 0.5 for main diagnosis, p = 0.16 for subtype). Accordingly, results were pooled over reviewers. For distinguishing normal/non-progressors from degenerative conditions, the proportions correctly diagnosed were higher with methods B and C than with A (p = 0.001, both tests). The difference between method B and C was not statistically significant (p = 0.18). For main diagnosis, the proportion of correct diagnoses were highest with method C for all three reviewers; however, this was not statistically significant comparing with method A (p = 0.23) or with method B (p = 0.16). For subtype diagnosis, there was some evidence that method C was better than method A (p = 0.01) and B (p = 0.048). Serial MRI and registration may improve visual diagnosis in dementia. (orig.)

  15. Does registration of serial MRI improve diagnosis of dementia?

    International Nuclear Information System (INIS)

    We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia. One hundred twenty subjects with clinical follow-up of at least 1 year with two scans were selected from a cognitive disorders clinic. Scans were reviewed as a single first scan (method A), two unregistered scans presented side-by-side (method B) and a registered pair (method C). Scans were presented to two neuroradiologists and a clinician together with approximate scan interval (if applicable) and age. Raters decided on a main and subtype diagnosis. There was no evidence that differences between methods (expressed as relative odds of a correct response) differed between reviewers (p = 0.17 for degenerative condition or not, p = 0.5 for main diagnosis, p = 0.16 for subtype). Accordingly, results were pooled over reviewers. For distinguishing normal/non-progressors from degenerative conditions, the proportions correctly diagnosed were higher with methods B and C than with A (p = 0.001, both tests). The difference between method B and C was not statistically significant (p = 0.18). For main diagnosis, the proportion of correct diagnoses were highest with method C for all three reviewers; however, this was not statistically significant comparing with method A (p = 0.23) or with method B (p = 0.16). For subtype diagnosis, there was some evidence that method C was better than method A (p = 0.01) and B (p = 0.048). Serial MRI and registration may improve visual diagnosis in dementia. (orig.)

  16. LHCb: SPECS: a Serial Protocol for the Experiment Control System of LHCb

    CERN Multimedia

    Charlet, D

    2007-01-01

    The SPECS is a single master, multi slave serial bus. It communicates between an unique master and up to 32 slaves (limit fixed by the address range), at a 10 MHz rate, thanks to 4 different unidirectional lines.

  17. Robust Optimization and Reflection Gain Enhancement of Serial Link System for Signal Integrity and Power Integrity

    Directory of Open Access Journals (Sweden)

    Rakesh Malik

    2011-08-01

    Full Text Available System level signal integrity and power integrity problems for high speed serial links have been explored in this paper. An example of the USB 2.0 IP has been used in this paper, but the analysis is generic for all serial links. This paper considers signal and power integrity as effects simultaneoulsy. A model is developed to optimize the performance of high speed serial link in terms of jitter and amplitude performance. Sensitivity analysis is carried out with a set of dependent parameters affecting the performance. Taguchi array optimization has been applied during the optimization process. Finally, reflection gain concept is also applied to further improve the performance for the eye diagram. A strong correlation between measured and simulated results is shown. A generic methodology for SI and PI for high speed serial links is presented with complete analysis of package, board, termination, squidd card, decoupling network etc

  18. Alur Kerja Tahap Produksi Karakter Animasi Serial 3D Menggunakan Perangkat Lunak Maxon Cinema 4D

    Directory of Open Access Journals (Sweden)

    Ardiyan

    2011-03-01

    Full Text Available 3D Animation serial for television needs have been showed in the national television program, especially fantasy theme and educational program for children. There are so many and sequential needs which tricked by instant and high-quality production so the work flow in creating 3D animation serial are facilitating the producers. The article will explain specifically how the software of Maxon Cinema 4D in process production in 3D animation serial. The article will also clarify and focus on how the work flow of Maxon Cinema 4D software in processing production and post-production stages. The writer does research including audio visual tutorial, end-result comparison and rendering time between some software, self-observation of work flow in creating 3D animation serial using Maxon Cinema 4D software and digital literature study (e-book.

  19. The International Standard Serial Number (ISSN) and Its Use by the United States Postal Service.

    Science.gov (United States)

    Bartley, Linda K.

    1980-01-01

    Describes the rationale and procedures for the implementation of the mandatory printing of ISSN on serials mailed at special rates through the United States mail. The article cites bibliographical, commercial, and managerial benefits for the information community. (Author/RAA)

  20. Serial fetal abdominal circumference measurements in predicting normal birth weight in gestational diabetes mellitus.

    LENUS (Irish Health Repository)

    Neff, Karl J

    2013-06-24

    To construct a clinical management matrix using serial fetal abdominal circumference measurements (ACMs) that will predict normal birth weight in pregnancies complicated by gestational diabetes (GDM) and reduce unnecessary ultrasound examination in women with GDM.