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Sample records for alexander disease serial

  1. Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matter

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    Voorn, J.P. van der [VU University Medical Center, Department of Child Neurology, Amsterdam (Netherlands); VU University Medical Center, Department of Pathology, Amsterdam (Netherlands); Pouwels, Petra J.W. [VU University Medical Center, Department of Physics and Medical Technology, Amsterdam (Netherlands); Salomons, Gajja S. [VU University Medical Center, Department of Clinical Chemistry (Metabolic Unit), Amsterdam (Netherlands); Barkhof, Frederik [VU University Medical Center, Department of Radiology, Amsterdam (Netherlands); Knaap, Marjo S. van der [VU University Medical Center, Department of Child Neurology, Amsterdam (Netherlands)

    2009-10-15

    Alexander disease is a rare disorder of the central nervous system with characteristic symmetric white matter abnormalities with frontal predominance on magnetic resonance (MR) images. Histopathology shows a lack of myelin in the affected white matter, variably interpreted as hypomyelination or demyelination. To increase our insight into the nature of the pathology leading to the MR imaging findings in Alexander disease, we applied serial MR imaging, spectroscopy, magnetization transfer (MT) imaging (MTI), and diffusion tensor imaging (DTI) in six patients with juvenile Alexander disease. The MR imaging protocol comprised T1- and T2-weighted spin echo images and fluid-attenuated inversion recovery images. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), and MT ratio (MTR) maps were generated, and MR spectroscopy concentrations were quantified for several metabolites. MR imaging showed similar cerebral white matter abnormalities in all patients, with only minor increase on prolonged follow-up, despite sometimes serious clinical progression. MR spectroscopy showed highly elevated levels of myo-inositol, lactate, and choline-containing compounds and decreased total N-acetyl-aspartate and N-acetyl-aspartyl-glutamate levels in the abnormal white matter. High values of ADC were observed, and both FA and MTR were attenuated. The sequential MR imaging findings in Alexander disease provide strong evidence against active demyelination as sole explanation for the underlying pathology. An alternative explanation for our spectroscopic, DTI, and MTI findings - which would suggest demyelination - could be hyperplasia and hypertrophy of astrocytes, as seen in low grade gliomas. (orig.)

  2. Genetics Home Reference: Alexander disease

    Science.gov (United States)

    ... up study of 22 Chinese children with Alexander disease and analysis of parental origin of de novo GFAP mutations. J Hum Genet. 2013 Apr;58(4):183-8. doi: 10.1038/jhg.2012.152. Epub 2013 Jan 31. Citation on ... GS. Alexander disease: ventricular garlands and abnormalities of the medulla and ...

  3. Alexander disease : Diagnosis with MR imaging

    NARCIS (Netherlands)

    van der Knaap, MS; Naidu, S; Breiter, SN; Blaser, S; Stroink, H; Spinger, S; Begeer, JC; van Coster, R; Barth, PG; Thomas, NH; Powers, JM; Valk, J.

    2001-01-01

    BACKGROUND AND PURPOSE: To date, the demonstration of Rosenthal fibers on brain biopsy or autopsy specimens is considered a prerequisite for a definitive diagnosis of Alexander disease. We initiated a multiinstitutional survey of MR abnormalities in both presumed and confirmed cases of Alexander dis

  4. Alexander disease with mild dorsal brainstem atrophy and infantile spasms.

    Science.gov (United States)

    Torisu, Hiroyuki; Yoshikawa, Yoko; Yamaguchi-Takada, Yui; Yano, Tamami; Sanefuji, Masafumi; Ishizaki, Yoshito; Sawaishi, Yukio; Hara, Toshiro

    2013-05-01

    We present the case of a Japanese male infant with Alexander disease who developed infantile spasms at 8 months of age. The patient had a cluster of partial seizures at 4 months of age. He presented with mild general hypotonia and developmental delay. Macrocephaly was not observed. Brain magnetic resonance imaging (MRI) findings fulfilled all MRI-based criteria for the diagnosis of Alexander disease and revealed mild atrophy of the dorsal pons and medulla oblongata with abnormal intensities. DNA analysis disclosed a novel heterozygous missense mutation (c.1154 C>T, p.S385F) in the glial fibrillary acidic protein gene. At 8 months of age, tonic spasms occurred, and electroencephalography (EEG) revealed hypsarrhythmia. Lamotrigine effectively controlled the infantile spasms and improved the abnormal EEG findings. Although most patients with infantile Alexander disease have epilepsy, infantile spasms are rare. This comorbid condition may be associated with the distribution of the brain lesions and the age at onset of Alexander disease.

  5. Alexander disease as a cause of nocturnal vomiting in a 7-year-old girl

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    Niinikoski, Harri [University of Turku, Department of Paediatrics, Turku (Finland); Haataja, Leena [University of Turku, Department of Paediatrics, Turku (Finland); University of Turku, Department of Pediatric Neurology, Turku (Finland); Brander, Antti [University of Tampere, Department of Radiology, Tampere (Finland); Valanne, Leena [University of Helsinki, Department of Radiology, Helsinki (Finland); Blaser, Susan [Hospital for Sick Children, Department of Radiology, Toronto (Canada)

    2009-08-15

    Alexander disease is a rare form of leukodystrophy with a highly variable clinical course. Occasionally night-time nausea and vomiting are the first symptoms of juvenile Alexander disease. A 7-year-old girl had recurrent night-time vomiting and her growth and weight gain had deteriorated after her sixth birthday. Cranial MRI demonstrated two small, symmetrical focal areas of abnormally high signal intensity in the dorsal medulla oblongata on T2-W and FLAIR images. These were suggestive of juvenile Alexander disease, and subsequent sequencing of the glial fibrillary acidic protein (GFAP) gene revealed a heterogeneous missense mutation in the GFAP gene in exon 6. Alexander disease should be considered in young patients with atypical anorexia nervosa-type symptoms. (orig.)

  6. Samuel Alexander Kinnier Wilson. Wilson's disease, Queen Square and neurology.

    Science.gov (United States)

    Broussolle, E; Trocello, J-M; Woimant, F; Lachaux, A; Quinn, N

    2013-12-01

    This historical article describes the life and work of the British physician Samuel Alexander Kinnier Wilson (1878-1937), who was one of the world's greatest neurologists of the first half of the 20th century. Early in his career, Wilson spent one year in Paris in 1903 where he learned from Pierre-Marie at Bicêtre Hospital. He subsequently retained uninterrupted links with French neurology. He also visited in Leipzig the German anatomist Paul Flechsig. In 1904, Wilson returned to London, where he worked for the rest of his life at the National Hospital for the Paralysed and Epileptic (later the National Hospital for Nervous Diseases, and today the National Hospital for Neurology and Neurosurgery) in Queen Square, and also at Kings' College Hospital. He wrote on 'the old motor system and the new', on disorders of motility and muscle tone, on the epilepsies, on aphasia, apraxia, tics, and pathologic laughing and crying, and most importantly on Wilson's disease. The other objective of our paper is to commemorate the centenary of Wilson's most important work published in 1912 in Brain, and also in Revue Neurologique, on an illness newly recognized and characterized by him entitled "Progressive lenticular degeneration, a familial nervous disease associated with liver cirrhosis". He analyzed 12 clinical cases, four of whom he followed himself, but also four cases previously published by others and a further two that he considered in retrospect had the same disease as he was describing. The pathological profile combined necrotic damage in the lenticular nuclei of the brain and hepatic cirrhosis. This major original work is summarized and discussed in the present paper. Wilson not only delineated what was later called hepato-lenticular degeneration and Wilson's disease, but also introduced for the first time the terms extrapyramidal syndrome and extrapyramidal system, stressing the role of the basal ganglia in motility. The present historical work emphasizes the special

  7. Infantile Refsum disease: serial evaluation with MRI.

    Science.gov (United States)

    Cakirer, Sinan; Savas, Mahmut R

    2005-02-01

    Refsum disease is a rare metabolic disorder, which is characterized by the accumulation of phytanic acid in the blood and tissues, including the brain. A variant of this condition that occurs in young children is called infantile Refsum disease. The MRI findings of symmetrical signal change involving the corticospinal tracts, cerebellar dentate nuclei, and corpus callosum are characteristic. We report the serial MRI findings of a child with this rare metabolic disorder.

  8. Infantile Refsum disease: serial evaluation with MRI

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    Cakirer, Sinan; Savas, Mahmut R. [Sisli Etfal Hospital, Neuroradiology Section, Department of Radiology, Istanbul (Turkey)

    2005-02-01

    Refsum disease is a rare metabolic disorder, which is characterized by the accumulation of phytanic acid in the blood and tissues, including the brain. A variant of this condition that occurs in young children is called infantile Refsum disease. The MRI findings of symmetrical signal change involving the corticospinal tracts, cerebellar dentate nuclei, and corpus callosum are characteristic. We report the serial MRI findings of a child with this rare metabolic disorder. (orig.)

  9. Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.

    Science.gov (United States)

    LaPash Daniels, Christine M; Paffenroth, Elizabeth; Austin, Elizabeth V; Glebov, Konstantin; Lewis, Diana; Walter, Jochen; Messing, Albee

    2015-01-01

    Alexander disease is a fatal neurodegenerative disease caused by mutations in the astrocyte intermediate filament glial fibrillary acidic protein (GFAP). The disease is characterized by elevated levels of GFAP and the formation of protein aggregates, known as Rosenthal fibers, within astrocytes. Lithium has previously been shown to decrease protein aggregates by increasing the autophagy pathway for protein degradation. In addition, lithium has also been reported to decrease activation of the transcription factor STAT3, which is a regulator of GFAP transcription and astrogliogenesis. Here we tested whether lithium treatment would decrease levels of GFAP in a mouse model of Alexander disease. Mice with the Gfap-R236H point mutation were fed lithium food pellets for 4 to 8 weeks. Four weeks of treatment with LiCl at 0.5% in food pellets decreased GFAP protein and transcripts in several brain regions, although with mild side effects and some mortality. Extending the duration of treatment to 8 weeks resulted in higher mortality, and again with a decrease in GFAP in the surviving animals. Indicators of autophagy, such as LC3, were not increased, suggesting that lithium may decrease levels of GFAP through other pathways. Lithium reduced the levels of phosphorylated STAT3, suggesting this as one pathway mediating the effects on GFAP. In conclusion, lithium has the potential to decrease GFAP levels in Alexander disease, but with a narrow therapeutic window separating efficacy and toxicity.

  10. GFAP expression as an indicator of disease severity in mouse models of Alexander disease

    Directory of Open Access Journals (Sweden)

    Albee Messing

    2013-03-01

    Full Text Available AxD (Alexander disease is a rare disorder caused by heterozygous mutations in GFAP (glial fibrillary acidic protein resulting in accumulation of the GFAP protein and elevation of Gfap mRNA. To test whether GFAP itself can serve as a biomarker of disease status or progression, we investigated two independent measures of GFAP expression in AxD mouse models, one using a genetic reporter of promoter activity and the other quantifying GFAP protein directly in a manner that could also be employed in human studies. Using a transgenic reporter line that expresses firefly luciferase under the control of the murine Gfap promoter (Gfap-luc, we found that luciferase activity reflected the regional CNS (central nervous system variability of Gfap mRNA in Gfap+/+ mice, and increased in mice containing a point mutation in Gfap that mimics a common human mutation in AxD (R239H in the human sequence, and R236H in the murine sequence. In a second set of studies, we quantified GFAP protein in CSF (cerebrospinal fluid taken from three different AxD mouse models and littermate controls. GFAP levels in CSF were increased in all three AxD models, in a manner corresponding to the concentrations of GFAP in brain. These studies demonstrate that transactivation of the Gfap promoter is an early and sustained indicator of the disease process in the mouse. Furthermore, GFAP in CSF serves as a potential biomarker that is comparable between mouse models and human patients.

  11. Screening for GFAP rearrangements in a cohort of Alexander disease and undetermined leukoencephalopathy patients.

    Science.gov (United States)

    Ferreira, Marie-Céleste; Dorboz, Imen; Rodriguez, Diana; Boespflug Tanguy, Odile

    2015-09-01

    Alexander disease (AxD), a fatal degenerative leukoencephalopathy, is caused by de novo heterozygous missense mutations in the Glial Fibrillary Acidic Protein (GFAP) gene. The pathological hallmark of the disease is the presence of Rosenthal fibers, cytoplasmic inclusions in astrocytes, composed mainly of GFAP, αB-crystallin and HSP27. To date, several patients with a typical presentation of the disease or displaying characteristic Rosenthal fibers in brain material have been reported with no GFAP mutation. Recently, several studies have demonstrated a correlation between Rosenthal fiber formation and wild-type GFAP overexpression, despite the absence of mutations. We tested the hypothesis that a GFAP gene rearrangement could modulate AxD severity or promote GFAP overexpression and aggregation, resulting in leukoencephalopathy. A QMPSF assay was validated for 11 exonic fragments: 3 in control genes (CFTR, DSCR1, F9) and 8 corresponding to GFAP exons. A total of 97 patients suspected of AxD were analyzed: 28 with a GFAP mutation; 69 with clinical and magnetic resonance imaging criteria compatible with the disease. Neither duplications nor deletions of GFAP were found, suggesting that GFAP coding-region rearrangements may not be involved in AxD or Alexander-related leukoencephalopathies. In addition, 80 patients with undetermined leukodystrophies, and negative for PLP1, GJA12, Sox10 and MCT8 mutations and PLP1 and Lamin B1 rearrangements, were tested. These patients were also negative for GFAP rearrangements. Other hypotheses should be investigated for a molecular diagnosis in patients with undetermined leukoencephalopathy: mutations in GFAP isoforms, splicing sites or regulatory regions, or defaults in genes encoding molecular partners of GFAP.

  12. Fibrinoid leukodystrophy (Alexander's disease-like disorder) in a young adult French bulldog.

    Science.gov (United States)

    Ito, Tsuyoshi; Uchida, Kazuyuki; Nakamura, Masatoshi; Nakashima, Ko; Suzuki, Kazuhiko; Nakayama, Hiroyuki

    2010-10-01

    The paper describes clinical and pathological features of Alexander's disease (AD)-like disorder in a 1 year and 8 months old French bulldog. Clinically, the dog exhibited megaesophagus, emaciation and weakness without any specific neurological symptoms. The dog died of aspiration pneumonia. On the gross observation of formalin-fixed brain, discolored foci were observed in the white matter of the cerebellum and brain stem. Histologically, numerous Rothenthal fibers and hypertrophic astrocytes were distributed especially in the perivascular, subependymal and subpial area of both the cerebrum and cerebellum. The Rosenthal fibers were intensely immunopositive for GFAP and ubiquitin. Demyelination of the white matter was occasionally found in the brain stem. The present case is likely to be categorized in the adult form of AD, though previous AD-like cases in dogs were in the juvenile form.

  13. The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease.

    Science.gov (United States)

    Sosunov, Alexander A; McKhann, Guy M; Goldman, James E

    2017-03-31

    Rosenthal fibers (RFs) are cytoplasmic, proteinaceous aggregates. They are the pathognomonic feature of the astrocyte pathology in Alexander Disease (AxD), a neurodegenerative disorder caused by heterozygous mutations in the GFAP gene, encoding glial fibrillary acidic protein (GFAP). Although RFs have been known for many years their origin and significance remain elusive issues. We have used mouse models of AxD based on the overexpression of human GFAP (transgenic, TG) and a point mutation in mouse GFAP (knock-in, KI) to examine the formation of RFs and to find astrocyte changes that correlate with the appearance of RFs. We found RFs of various sizes and shapes. The smallest ones appear as granular depositions on intermediate filaments. These contain GFAP and the small heat shock protein, alphaB-crystallin. Their aggregation appears to give rise to large RFs. The appearance of new RFs and the growth of previously formed RFs occur over time. We determined that DAPI is a reliable marker of RFs and in parallel with Fluoro-Jade B (FJB) staining defined a high variability in the appearance of RFs, even in neighboring astrocytes. Although many astrocytes in AxD with increased levels of GFAP and with or without RFs change their phenotype, only some cells with large numbers of RFs show a profound reconstruction of cellular processes, with a loss of fine distal processes and the appearance of large, lobulated nuclei, likely due to arrested mitosis. We conclude that 1) RFs appear to originate as small, osmiophilic masses containing both GFAP and alphaB-crystallin deposited on bundles of intermediate filaments. 2) RFs continue to form within AxD astrocytes over time. 3) DAPI is a reliable marker for RFs and can be used with immunolabeling. 4) RFs appear to interfere with the successful completion of astrocyte mitosis and cell division.

  14. Alexander Fleming

    Institute of Scientific and Technical Information of China (English)

    李琳

    2006-01-01

    Alexander Fleming was born in a remote, rural part of Scotland. After completing school he was employed by a shipping firm, though he didn’t much like it. In 1900, when the Boer War broke out between the United Kingdom and its colonies in southern Africa, Fleming and two brothers joined a Scottish regiment, which turned out to be as much a sporting club as anything. Soon after this, he got a legacy of 250 pounds from his uncle and decided to study medicine.

  15. Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic.

    Science.gov (United States)

    Boczek, Nicole J; Sigafoos, Ashley N; Zimmermann, Michael T; Maus, Rachel L; Cousin, Margot A; Blackburn, Patrick R; Urrutia, Raul; Clark, Karl J; Patterson, Marc C; Wick, Myra J; Klee, Eric W

    2016-09-01

    A de novo GFAP variant, p.R376W, was identified in a child presenting with hypotonia, developmental delay, and abnormal brain MRI. Following the 2015 ACMG variant classification guidelines and the functional studies showing protein aggregate formation in vitro, p.R376W should be classified as a pathogenic variant, causative for Alexander disease.

  16. Serial CT scans and Menkes' kinky hair disease

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    Nakada, Eizo; Kameyama, Junji; Yoshimitsu, Hajime; Mori, Mikio; Tanaka, Mutsuo; Yoshimitsu, Kazunori.

    1988-02-01

    Menkes' kinky hair disease is a sex-linked recessive disorder of copper metabolism, characterized by progressive psychomotor deterioration, seizures, and peculiar hair structure. We examined serial CT scans of patients with this disease. A 2,210-g male infant was delivered after an uneventful gestation of 36 weeks. His one-minute Apgar score was 9. His uncle had died at 1 year of age. His first cousin was also diagnosed as having Menkes' kinky hair disease when our patient was 2 years old. Shortly after birth he had mild respiratory distress. At 5 days of age, he developed setting-sun signs. The first CT scan, at 10 days of age, revealed mild posterior fossa hemorrhages. At 3 months of age, myoclonic seizures began, and the CT scan revealed subdural effusion and mild brain atrophy. The seizures were controllable by using phenobarbital, valproic acid, and nitrazepam. He did not follow light or a fixate, but the fundi were normal. He was diffusely hypotonic. At 9 months of age, the seizures became uncontrollable. The CT scans at 15 and 31 months of age showed subdural hemorrhage and/or brain atrophy. At 15 months of age, the serum copper level was 42 ..mu.. g/dl, while the serum ceruloplasmin level was 3.2 mg/dl. He exhibited severe developmental failure. At 4 years of age, he died.

  17. Computing the Alexander Polynomial Numerically

    DEFF Research Database (Denmark)

    Hansen, Mikael Sonne

    2006-01-01

    Explains how to construct the Alexander Matrix and how this can be used to compute the Alexander polynomial numerically.......Explains how to construct the Alexander Matrix and how this can be used to compute the Alexander polynomial numerically....

  18. Remembering Alexander Meiklejohn.

    Science.gov (United States)

    Tussman, Joseph

    1984-01-01

    A former student of Alexander Meiklejohn, a member of the Experimental College movement on the 1930s, describes his impressions of Meiklejohn's life, leadership qualities, and personal characteristics. (MSE)

  19. Serial measurements of high-sensitivity cardiac troponin T after exercise stress test in stable coronary artery disease

    DEFF Research Database (Denmark)

    Axelsson, Anna; Ruwald, Martin Huth; Dalsgaard, Morten;

    2013-01-01

    The aim was to assess serial measurements of high-sensitivity cardiac troponin T (hs-cTNT) post-exercise in patients with stable coronary artery disease (CAD).......The aim was to assess serial measurements of high-sensitivity cardiac troponin T (hs-cTNT) post-exercise in patients with stable coronary artery disease (CAD)....

  20. Serial Ultrasonography Assessments of a Testicular Infarction Mimicking Testicular Tumor in a Behcet Disease Patient

    Directory of Open Access Journals (Sweden)

    Zeid Al-Ani

    2014-03-01

    Full Text Available Behcet disease (BD, a vasculitic disease, may present with a broad range of systemic manifestations. Urologic complications are rarely described in the literature, but when they occur, they present as epididymo-orchitis. We describe a rare case of testicular infarction in a patient with BD followed up with serial ultrasound imaging. We highlight the diagnostic challenges when presented with testicular pain in a patient with BD and the potential consequences in the management.

  1. Memorial Alexander Center

    Directory of Open Access Journals (Sweden)

    AECK Associates, Arquitectos

    1958-05-01

    Full Text Available En Atlanta, el Instituto Tecnológico de Georgia acaba de ampliar sus instalaciones deportivas, construyendo el Alexander Memorial Center. Consta este nuevo Centro de dos edificios: una pista de baloncesto cubierta y un edificio anejo con vestuarios, duchas, una pista de entrenamiento, equipos técnicos y la emisora de radio Georgia Tech W. G. S. T.

  2. The genomes of Marek’s disease virus exist as quasispecies at defined intervals during serial passage-induced attenuation

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    Marek’s disease (MD) is a lymphoproliferative disease of chickens caused by gallid herpesvirus type 2 (GaHV-2). The disease is controlled through mass vaccination with live-attenuated strains. Attenuation of oncogenic GaHV-2 involves the serial passage of a virulent field isolate in avian embryo fib...

  3. Adult-onset Alexander disease with typical "tadpole" brainstem atrophy and unusual bilateral basal ganglia involvement: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Sakoe Kumi

    2010-04-01

    Full Text Available Abstract Background Alexander disease (ALX is a rare neurological disorder characterized by white matter degeneration and cytoplasmic inclusions in astrocytes called Rosenthal fibers, labeled by antibodies against glial fibrillary acidic protein (GFAP. Three subtypes are distinguished according to age at onset: infantile (under age 2, juvenile (age 2 to 12 and adult (over age 12. Following the identification of heterozygous mutations in GFAP that cause this disease, cases of adult-onset ALX have been increasingly reported. Case Presentation We present a 60-year-old Japanese man with an unremarkable past and no family history of ALX. After head trauma in a traffic accident at the age of 46, his character changed, and dementia and dysarthria developed, but he remained independent. Spastic paresis and dysphagia were observed at age 57 and 59, respectively, and worsened progressively. Neurological examination at the age of 60 revealed dementia, pseudobulbar palsy, left-side predominant spastic tetraparesis, axial rigidity, bradykinesia and gaze-evoked nystagmus. Brain MRI showed tadpole-like atrophy of the brainstem, caused by marked atrophy of the medulla oblongata, cervical spinal cord and midbrain tegmentum, with an intact pontine base. Analysis of the GFAP gene revealed a heterozygous missense mutation, c.827G>T, p.R276L, which was already shown to be pathogenic in a case of pathologically proven hereditary adult-onset ALX. Conclusion The typical tadpole-like appearance of the brainstem is strongly suggestive of adult-onset ALX, and should lead to a genetic investigation of the GFAP gene. The unusual feature of this patient is the symmetrical involvement of the basal ganglia, which is rarely observed in the adult form of the disease. More patients must be examined to confirm, clinically and neuroradiologically, extrapyramidal involvement of the basal ganglia in adult-onset ALX.

  4. Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.

    Science.gov (United States)

    Watts, Joel C; Condello, Carlo; Stöhr, Jan; Oehler, Abby; Lee, Joanne; DeArmond, Stephen J; Lannfelt, Lars; Ingelsson, Martin; Giles, Kurt; Prusiner, Stanley B

    2014-07-15

    An increasing number of studies argues that self-propagating protein conformations (i.e., prions) feature in the pathogenesis of several common neurodegenerative diseases. Mounting evidence contends that aggregates of the amyloid-β (Aβ) peptide become self-propagating in Alzheimer's disease (AD) patients. An important characteristic of prions is their ability to replicate distinct strains, the biological information for which is enciphered within different conformations of protein aggregates. To investigate whether distinct strains of Aβ prions can be discerned in AD patients, we performed transmission studies in susceptible transgenic mice using brain homogenates from sporadic or heritable (Arctic and Swedish) AD cases. Mice inoculated with the Arctic AD sample exhibited a pathology that could be distinguished from mice inoculated with the Swedish or sporadic AD samples, which was judged by differential accumulation of Aβ isoforms and the morphology of cerebrovascular Aβ deposition. Unlike Swedish AD- or sporadic AD-inoculated animals, Arctic AD-inoculated mice, like Arctic AD patients, displayed a prominent Aβ38-containing cerebral amyloid angiopathy. The divergent transmission behavior of the Arctic AD sample compared with the Swedish and sporadic AD samples was maintained during second passage in mice, showing that Aβ strains are serially transmissible. We conclude that at least two distinct strains of Aβ prions can be discerned in the brains of AD patients and that strain fidelity was preserved on serial passage in mice. Our results provide a potential explanation for the clinical and pathological heterogeneity observed in AD patients.

  5. Serial chest CT findings in interstitial lung disease associated with polymyositis-dermatomyositis

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    Bonnefoy, Olivier; Ferretti, Gilbert; Calaque, Olivier; Coulomb, Max; Begueret, Hugues; Beylot-Barry, Marie; Laurent, Francois E-mail: francois.laurent@chu-bordeaux.fr

    2004-03-01

    Objective: A retrospective study was carried out in two institutions to determine serial changes in the pattern, distribution, and extent of interstitial lung disease (ILD) associated with polymyositis (PM)-dermatomyositis (DM) using HRCT. Subjects and methods: Twenty patients with PM-DM and clinical suspicion of ILD who underwent at least two serial HRCT examinations were retrospectively evaluated by two readers. Patients were classified according to the dominant CT pattern which was correlated with clinical evolution and underlying histology when available (n=6). Results: Patients were classified into four groups according to the dominant pattern: ground-glass attenuation and reticulation (group 1, n=9); honeycombing (group 2, n=4); airspace consolidation (group 3, n=4), and normal or almost normal lung (group 4, n=3). Under medical treatment, serial HRCT showed that the extent of areas of ground-glass opacities (group 1) decreased in five patients, stabilized in two, and increased in two. Pathologic findings demonstrated usual interstitial pneumonia (UIP) in two cases and unspecified interstitial pneumonia in one. In group 2, extent of honeycombing increased in three cases and stabilized in one. In group 3, dramatic resolution of airspace consolidation occurred in three cases. Clinical deterioration with extensive consolidation at CT and diffuse alveolar damage (DAD) at histology occurred in one patient of each of the three previous groups. Lesions stayed invisible or progressed slightly in the fourth group. Conclusion: In ILD associated with PM-DM, clinical deterioration and DAD in the follow-up can be observed whatever the HRCT pattern. However, unfavorable evolution is constant when honeycombing is present at the initial CT.

  6. Efficacy of serial medical surveillance for chronic beryllium disease in a beryllium machining plant.

    Science.gov (United States)

    Newman, L S; Mroz, M M; Maier, L A; Daniloff, E M; Balkissoon, R

    2001-03-01

    There is limited information on the use of the blood beryllium lymphocyte proliferation test (BeLPT) at regular intervals in medical surveillance. Employees of a beryllium machining plant were screened with the BeLPT biennially, and new employees were screened within 3 months of hire. Of 235 employees screened from 1995 to 1997, a total of 15 (6.4%) had confirmed abnormal BeLPT results indicating beryllium sensitization; nine of these employees were diagnosed with chronic beryllium disease. Four of the 15 cases were diagnosed within 3 months of first exposure. When 187 of the 235 employees participated in biennial screening in 1997 to 1999, seven more had developed beryllium sensitization or chronic beryllium disease, increasing the overall rate to 9.4% (22 of 235). The blood BeLPT should be used serially in beryllium disease surveillance to capture new or missed cases of sensitization and disease. Beryllium sensitization and chronic beryllium disease can occur within 50 days of first exposure in modern industry.

  7. Alexander Duals of Multipermutohedron Ideals

    Indian Academy of Sciences (India)

    Ajay Kumar; Chanchal Kumar

    2014-02-01

    An Alexander dual of a multipermutohedron ideal has many combinatorial properties. The standard monomials of an Artinian quotient of such a dual correspond bijectively to some -parking functions, and many interesting properties of these Artinian quotients are obtained by Postnikov and Shapiro (Trans. Am. Math. Soc. 356 (2004) 3109–3142). Using the multigraded Hilbert series of an Artinian quotient of an Alexander dual of multipermutohedron ideals, we obtained a simple proof of Steck determinant formula for enumeration of -parking functions. A combinatorial formula for all the multigraded Betti numbers of an Alexander dual of multipermutohedron ideals are also obtained.

  8. Alexander Lowen: An Energetic Man.

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    Good, Glenn E.; Rabinowitz, Fredric E.

    1992-01-01

    Presents interview with Alexander Lowen, prominent psychotherapist, who discusses his personal and professional development, as well as the evolution of bioenergetic analysis. Includes a list of suggested readings by Lowen. (Author/NB)

  9. Leukocyte scintigraphy: correlation of serial scintigraphic findings and clinical progression of inflammatory bowel disease

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    Ho, Y.; Kelly, M.J.; Kaliff, V. [Alfred Hospital, Prahan, VIC (Australia). Department of Nuclear Medicine

    1997-12-01

    Full text: This study was performed (a) to determine whether the clinical progress of individual patients with inflammatory bowel disease mirrored changes in leukocyte scans, and (b) to assess the reasons for significant discrepancies. Two nuclear medicine physicians reviewed 44 white cell scans in 20 consecutive patients (4 males, 18 females) who were referred for two or more leukocyte scans (using either the {sup 111}In Oxine or {sup 99m}Tc HMPAO labelling methods) by three gastroenterologists between 1 January 1992 and 1 June 1996. The sequential scanpairs (range 2-18 months apart) were classified by consensus reading as showing no change, more severe or less severe disease. Questionnaires were sent to the referring gastroenterologists to determine whether the overall clinical status of each patient was unchanged, better or worse in the interval between the two scans. There was complete agreement between clinical and scintigraphic assessment in 45% (10/22) of the study pairs. Review of responses of the three individual gastroenterologists showed a wide range of agreement (4/4, 4/5, 2/13). Review of data showed that most disagreement was based on subjective clinical assessment, and hence of uncertain significance. In two patients, however, potentially preventable false negative leukocyte scans occurred in patients with active proctitis. This may be overcome by rigorous attention to ensure complete emptying of radioactivity from the bladder when {sup 99m}Tc HMPAO is used. It was concluded that serial leukocyte scans add to clinical assessment but careful technique is needed to avoid false negative scans in the rectum

  10. Sir Alexander Fleming: Scottish researcher who discovered penicillin.

    Science.gov (United States)

    Ligon, B Lee

    2004-01-01

    The discovery and development of penicillin changed the entire direction of approaches to treating infectious diseases and saved the lives of millions of people. Indeed, the development of penicillin was a watershed event in the battle against infectious diseases, and the individual who discovered it, Sir Alexander Fleming, remains a prominent individual in the annals of medical history. This article focuses primarily on the personal life of Alexander Fleming, an individual who had a remarkable diversity of interests and who made many contributions to science and medicine.

  11. Conjecture of Alexander and Orbach.

    Science.gov (United States)

    Rudra, Jayanta; Doiron, Curtis

    2009-03-01

    The dynamical properties of fractal networks have received wide range of attention. Works on this area by several pioneering authors^1-2 have led to the introduction of the spectral dimension that dictates the dynamic properties on a fractal lattice. Most of the studies involving spectral dimension have been performed on a type of fractal lattice known as percolation network. Alexander and Orbach^2 conjectured that the spectral dimension might be exactly 4/3 for percolation networks with Euclidean dimension de >= 2. Recent numerical simulations, however, could not decisively prove or disprove this conjecture, although there are other indirect evidences that it is true. We apply a stochastic approach^3 to determine the spectral dimension of percolation network for de >= 2 and check the validity of the Alexander-Orbach conjecture. Our preliminary results on 2- and 3-dimensional percolation networks indeed show that Alexander-Orbach conjecture is true, resolving a long-standing debate. References: 1. P. G. deGennes, La Recherche 7 (1976) 919. 2. S. Alexander and R. Orbach, J. Phys. Lett. (Paris) 43 (1982) L625. 3. J. Rudra and J. Kozak, Phys. Lett A 151 (1990) 429.

  12. Serial position effects scoring in the assessment of memory in Alzheimer's disease and major depression

    NARCIS (Netherlands)

    Bemelmans, Karel Jozef

    2009-01-01

    The objective of this thesis was to validate serial position effects (SPE’S) scoring in the Rey Auditory Verbal Learning Test (RAVLT). The RAVLT is a much used clinical method for assessing memory performance, but the method of scoring obfuscates that two memory processes underlie free recall. This

  13. Serial MRI Features of Canine GM1 Gangliosidosis: A Possible Imaging Biomarker for Diagnosis and Progression of the Disease

    Directory of Open Access Journals (Sweden)

    Daisuke Hasegawa

    2012-01-01

    Full Text Available GM1 gangliosidosis is a fatal neurodegenerative lysosomal storage disease caused by an autosomal recessively inherited deficiency of β-galactosidase activity. Effective therapies need to be developed to treat the disease. In Shiba Inu dogs, one of the canine GM1 gangliosidosis models, neurological signs of the disease, including ataxia, start at approximately 5 months of age and progress until the terminal stage at 12 to 15 months of age. In the present study, serial MR images were taken of an affected dog from a model colony of GM1 gangliosidosis and 4 sporadic clinical cases demonstrating the same mutation in order to characterize the MRI features of this canine GM1 gangliosidosis. By 2 months of age at the latest and persisting until the terminal stage of the disease, the MR findings consistently displayed diffuse hyperintensity in the white matter of the entire cerebrum on T2-weighted images. In addition, brain atrophy manifested at 9 months of age and progressed thereafter. Although a definitive diagnosis depends on biochemical and genetic analyses, these MR characteristics could serve as a diagnostic marker in suspect animals with or without neurological signs. Furthermore, serial changes in MR images could be used as a biomarker to noninvasively monitor the efficacy of newly developed therapeutic strategies.

  14. Representations of Knot Groups and Twisted Alexander Polynomials

    Institute of Scientific and Technical Information of China (English)

    Xiao Song LIN

    2001-01-01

    We present a twisted version of the Alexander polynomial associated with a matrix representation of the knot group. Examples of two knots with the same Alexander module but differenttwisted Alexander polynomials are given.

  15. Robert Alexander and His Passionate Philosophy (Profile).

    Science.gov (United States)

    Bosseau, Remi Barclay

    1994-01-01

    Discusses the passionate philosophy of Robert Alexander, founder and director of living stage theater company and his views of art, creativity, the entire process of learning, politics, philosophy, and hope. Presents several excerpts from Alexander's presentations for artists and teachers during Living Stage residencies in cities around the…

  16. Dancers' Application of the Alexander Technique

    Science.gov (United States)

    Fortin, Sylvie; Girard, Fernande

    2005-01-01

    This qualitative study describes the experience of professional contemporary dancers studying and applying the Alexander Technique to their dancing. This study was motivated by: 1. years of teaching both dance and somatics, 2. a strong desire to better understand how the Alexander Technique can be applied by dancers, and 3. a gap that the…

  17. Serial Pursuits

    OpenAIRE

    Mabb, David; Parekh, Manisha; Dayanita, Dayanita Singh; Audiobombing Crew,

    2011-01-01

    Nature Morte is pleased to announce „Serial Pursuits,“ a group exhibition in which recent works in various media by David Mabb, Manisha Parekh, Dayanita Singh and Audiobombing Crew will be brought together to present an exploration of art works created as sets or in sequences. The highlight of the opening night will be a performance by Audiobombing Crew. Founded by Markus Zull and Stephan Ebersthäuser in 2003, the sound art collective creates serial sound loops, which are collaged togethe...

  18. Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease.

    Science.gov (United States)

    Trueman, R C; Dunnett, S B; Jones, L; Brooks, S P

    2012-06-01

    Huntington's disease is an autosomal dominant genetic disorder, with motor, cognitive and psychiatric symptoms. To date there is no cure. In order to understand better this disease and to develop novel treatments, many genetically modified animal models of Huntington's disease have been created. However, to utilize these models fully, appropriate functional assays need to be developed for behavioural assessments of the mice. Various facets of attention have been reported to be affected in Huntington's disease patients, and the Hdh(Q92/Q92) mice have been shown to have deficits on operant tasks which have attentional components. In the present study, the Hdh(Q92/Q92) mouse model is assessed on a well established test of attentional function, the operant 5-choice serial reaction time task (5-CSRT), in which the mice must respond with a nose poke to light stimuli presented randomly across a 5 hole light array to receive a reward. In the present paper, the Hdh(Q92/Q92) mice exhibited deficits on the 5-CSRT when pseudorandomly presented with stimuli of different durations. However, alterations in the pacing of the task, therefore requiring an increase in sustained attention, did not affect the Hdh(Q92/Q92) mice more than their wildtype littermates. This study indicates that the Hdh(Q92/Q92) mice may have deficits in aspects of attentional function, in particular disruption in the ability to maintain attention in the visuospatial domain, suggesting that this knock-in mouse model of Huntington's disease may be a relevant model of the disease for the testing of novel therapeutic interventions.

  19. Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease.

    Science.gov (United States)

    Olsson, Eleonor; Winter, Christof; George, Anthony; Chen, Yilun; Howlin, Jillian; Tang, Man-Hung Eric; Dahlgren, Malin; Schulz, Ralph; Grabau, Dorthe; van Westen, Danielle; Fernö, Mårten; Ingvar, Christian; Rose, Carsten; Bendahl, Pär-Ola; Rydén, Lisa; Borg, Åke; Gruvberger-Saal, Sofia K; Jernström, Helena; Saal, Lao H

    2015-05-18

    Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it is rarely curable. Cell-free circulating tumor DNA (ctDNA) contains tumor-specific chromosomal rearrangements that may be interrogated in blood plasma. We evaluated serial monitoring of ctDNA for earlier detection of metastasis in a retrospective study of 20 patients diagnosed with primary breast cancer and long follow-up. Using an approach combining low-coverage whole-genome sequencing of primary tumors and quantification of tumor-specific rearrangements in plasma by droplet digital PCR, we identify for the first time that ctDNA monitoring is highly accurate for postsurgical discrimination between patients with (93%) and without (100%) eventual clinically detected recurrence. ctDNA-based detection preceded clinical detection of metastasis in 86% of patients with an average lead time of 11 months (range 0-37 months), whereas patients with long-term disease-free survival had undetectable ctDNA postoperatively. ctDNA quantity was predictive of poor survival. These findings establish the rationale for larger validation studies in early breast cancer to evaluate ctDNA as a monitoring tool for early metastasis detection, therapy modification, and to aid in avoidance of overtreatment.

  20. Clinical and genetic study of twelve Chinese patients with Alexander disease%亚历山大病12例中国患儿临床及遗传学研究

    Institute of Scientific and Technical Information of China (English)

    臧莉莉; 吴晔; 王静敏; 顾强; 姜玉武; 高志杰; 杨艳玲; 肖江喜; 吴希如

    2012-01-01

    Objective To delineate the phenotype and genotype characteristics in 12 Chinese children with Alexander disease ( AD),which is helpful for the molecular diagnosis and genetic counseling in China.Methods Clinical diagnosis of AD was based on MRI criteria proposed by van der Knaarp in 2001.Included AD patients were followed up for 0.50-3.67 years.Mutations in GFAP were detected by DNA sequencing.Results The 12 cases of AD were clinically diagnosed.Age of first visit was 4.87 years (0.75-12.00 years),with 3 type s of chief complaints:developmental delay in 3,recurrent seizures in 7,unable to walk after falling in 2.Average head circumference was 52.34 cm (44-58 cm),which larger than age-matched average by 6.45% ( 1.80% -13.95% ).On the first visit,scaling according to Gross motor functional classification system ( GMFCS ) was performed,with GMFCS Ⅰ in 8,Ⅱ in 3,V in 1.Mild to severe cognitive dysfunction were found in 8,and seizures in 11 cases.The 12 patients were followed up for 0.50-3.67 years,their motor and cognitive function remained stable. Episodic aggravations provoked by fever or falling were observed in 5 cases (41.67%). Heterozygous missense mutations of GFAP were detected in 12 patients.All mutations were de novo; 3 out of 10 mutations identified were novel.R79 and P239 were hot mutations,which was consistent with previous reports.Mutations were located in exon 1 in 8 cases.Conclusions The phenotype in these patients is characterized by slower progression compared with reports from other population and high incidence of seizures.And episodic aggravations provoked by fever or falling were more common.The genotype characteristics are consistent with previous reports.The results of this research expanded the number of patients with Alexander disease found to have GFAP coding mutations in China.%目的 了解12例中国亚历山大病(Alexander disease,AD)患儿的临床表型及遗传学特点,为在国内开展该病的分子诊断及

  1. "Most brilliant in judgment": Alexander the Great and Aristotle.

    Science.gov (United States)

    Lainas, Panagiotis; Panutsopulos, Dimitrios; Skandalakis, Panagiotis N; Zoras, Odysseas; Skandalakis, John E

    2005-03-01

    From historical sources, it is evident that Alexander the Great was indebted to one of his teachers, Aristotle of Stagira. It was the teaching of Aristotle that evoked all the nascent talents of young Alexander and turned him into a great man. Alexander was extremely interested in the secrets of medicine and considered it an art. The medical knowledge he acquired from Aristotle may have saved his life and the lives of his troops on many occasions. If Alexander did not possess medical knowledge and if his everyday life had not been so greatly influenced by medicine, he might never have been able to create his empire.

  2. Decreasing Serial Cost Sharing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Østerdal, Lars Peter

    The increasing serial cost sharing rule of Moulin and Shenker [Econometrica 60 (1992) 1009] and the decreasing serial rule of de Frutos [Journal of Economic Theory 79 (1998) 245] have attracted attention due to their intuitive appeal and striking incentive properties. An axiomatic characterization...... of the increasing serial rule was provided by Moulin and Shenker [Journal of Economic Theory 64 (1994) 178]. This paper gives an axiomatic characterization of the decreasing serial rule...

  3. Decreasing serial cost sharing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Østerdal, Lars Peter Raahave

    2009-01-01

    The increasing serial cost sharing rule of Moulin and Shenker (Econometrica 60:1009-1037, 1992) and the decreasing serial rule of de Frutos (J Econ Theory 79:245-275, 1998) are known by their intuitive appeal and striking incentive properties. An axiomatic characterization of the increasing serial...

  4. Twisted Alexander polynomials of hyperbolic knots

    CERN Document Server

    Dunfield, Nathan M; Jackson, Nicholas

    2011-01-01

    We study a twisted Alexander polynomial naturally associated to a hyperbolic knot in an integer homology 3-sphere via a lift of the holonomy representation to SL(2, C). It is an unambiguous symmetric Laurent polynomial whose coefficients lie in the trace field of the knot. It contains information about genus, fibering, and chirality, and moreover is powerful enough to sometimes detect mutation. We calculated this invariant numerically for all 313,209 hyperbolic knots in S^3 with at most 15 crossings, and found that in all cases it gave a sharp bound on the genus of the knot and determined both fibering and chirality. We also study how such twisted Alexander polynomials vary as one moves around in an irreducible component X_0 of the SL(2, C)-character variety of the knot group. We show how to understand all of these polynomials at once in terms of a polynomial whose coefficients lie in the function field of X_0. We use this to help explain some of the patterns observed for knots in S^3, and explore a potential...

  5. The Alexander the First collection of the Lausanne Museum

    NARCIS (Netherlands)

    Minina, E.L.

    2004-01-01

    Study of written sources in archives sometimes allows to restore the history of collections. A good example is the Alexander the First collection. In 1819, de la Harpe had sent an Etruscan vase to Alexander I as a gift, and had received a collection of Russian minerals in return. Alexander’s collect

  6. The Greek Phyllada and the Old Serbian Alexander Romance

    Directory of Open Access Journals (Sweden)

    Krzysztof Usakiewicz

    2015-06-01

    Full Text Available The Greek Phyllada and the Old Serbian Alexander Romance The texts presents chosen fragments of the Greek "Phyllada", or the story about Alexander the Great, and its Polish translation, with an introduction commenting the relation between the Greek and Serbian version of Alexader's gesta.

  7. A Study of Combined Arms Warfare by Alexander the Great.

    Science.gov (United States)

    2007-11-02

    Alexander’s mother Olympias. She had previously been set aside by Philip 19 for a new queen, Cleopatra . Olympias, acting without Alexander’s knowledge...had Cleopatra and her infant daughter put to death and eliminated any further legal claims to the throne (Warry 71). Upon his succession to the

  8. Serial color Doppler flow of uterine vasculature combined with serum beta-hCG measurements for improved monitoring of patients with gestational trophoblastic disease. A preliminary report.

    Science.gov (United States)

    Maymon, R; Schneider, D; Shulman, A; Bukowsky, I; Weinraub, Z

    1996-01-01

    Weekly serum beta-hCG measurements and transvaginal ultrasound scans coupled with color Doppler flow were performed on 8 patients with hydatidiform mole. Two patients later developed persistent trophoblastic disease, necessitating chemotherapy. The correlation coefficients between Doppler flow indices, systolic-diastolic (S/D) ratio and pulsatility index (PI) with log beta-hCG were -0.96 and -0.97, respectively. The weekly S/D and PI indices were plotted on an individual curve. Only the 2 patients who developed persistent gestational trophoblastic disease had PI index levels of < or = 1.5 as early as 2 weeks after molar evacuation. At that stage their serum beta-hCG levels were not different from some of the other patients. In this preliminary report, the regression of the disease could be reliably assessed by observing the changes in low resistance flow which paralleled the gradual decrements in serial beta-hCG levels. Thus, the contribution of this noninvasive imaging technique encourages the authors to further investigate Doppler flow monitoring among a larger sample of patients suffering from various gestational trophoblastic diseases.

  9. Eigenvalue conjecture and colored Alexander polynomials

    CERN Document Server

    Mironov, A

    2016-01-01

    We connect two important conjectures in the theory of knot polynomials. The first one is the property Al_R(q) = Al_{[1]}(q^{|R|}) for all single hook Young diagrams R, which is known to hold for all knots. The second conjecture claims that all the mixing matrices U_{i} in the relation {\\cal R}_i = U_i{\\cal R}_1U_i^{-1} between the i-th and the first generators {\\cal R}_i of the braid group are universally expressible through the eigenvalues of {\\cal R}_1. Since the above property of Alexander polynomials is very well tested, this relation provides a new support to the eigenvalue conjecture, especially for i>2, when its direct check by evaluation of the Racah matrices and their convolutions is technically difficult.

  10. Alexander von Humboldt in Daniel Kehlmanns Welt

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2012-12-01

    Full Text Available Zusammenfassung Wie stark sich im Verlauf des zurückliegenden Vierteljahrhunderts der Bekanntheitsgrad Alexander von Humboldts in der deutschsprachigen Öffentlichkeit verändert hat, zeigen nicht nur Fernsehumfragen zu den berühmtesten Deutschen, in denen Alexander von Humboldt mittlerweile figuriert, oder Fernsehserien, die über aktuelle Expeditionen berichten und auf Humboldts Namen zurückgreifen. Am deutlichsten vielleicht belegt dies der enorme Erfolg von Daniel Kehlmanns Roman Die Vermessung der Welt, der ohne die zuvor skizzierte Entwicklung nicht denkbar gewesen wäre. Es ist vor diesem Hintergrund nicht nur reizvoll, sondern aufschlußreich, sich mit dem großen Erfolg dieses kleinen Romans zu beschäftigen. Worum geht es in Die Vermessung der Welt? Und wie läßt sich das „Phänomen Kehlmann“ aus etwas größerer Distanz erklären? Abstract In the last 25 years, Alexander von Humboldt‘s popularity has radically changed in the german-speaking public opinion. Proof of this are not only television surveys about the most famous germans - in which Alexander von Humboldt now regularly figures - or television series about contemporary expeditions, which constantly refer to Humboldt‘s name; perhaps what most clearly verifies this change is the great success of Daniel Kehlmann‘s novel Die Vermessung der Welt. Without the recent developments outlined above, this novel‘s degree of impact would have been unimaginable. To study the great success of this text against this backdrop is not only attractive, but also revealing. What is Die Vermessung der Welt really about? And how can we explain the „Kehlmann phenomenon“ from a greater distance? Resumen La popularidad de Alejandro de Humboldt ha cambiado profundamente dentro del último cuarto de siglo en la opinión pública de habla alemana. Prueba de esto son no sólo las encuestas televisivas sobre los alemanes más famosos, dentro de las cuales figura en estos momentos Alejandro

  11. Successful polymyxin B hemoperfusion treatment associated with serial reduction of serum anti-CADM-140/MDA5 antibody levels in rapidly progressive interstitial lung disease with amyopathic dermatomyositis.

    Science.gov (United States)

    Teruya, Aoi; Kawamura, Kodai; Ichikado, Kazuya; Sato, Shinji; Yasuda, Yuko; Yoshioka, Masakazu

    2013-12-01

    Clinically amyopathic dermatomyositis (CADM), a subtype of dermatomyositis with subtle or no muscle involvement, is occasionally accompanied by fatal, rapidly progressive interstitial lung disease (RP-ILD) that is resistant to aggressive immunosuppressive therapy. The presence of anti-CADM-140/MDA5 antibodies is diagnostic for patients with dermatomyositis (particularly CADM) and is known to be strongly associated with the pathogenesis, disease activity, and mortality of RP-ILD. Polymyxin-B direct hemoperfusion (PMX-DHP), originally developed for the removal of endotoxin, has been demonstrated to be effective for treating various types of acute respiratory failure. We describe a patient with amyopathic dermatomyositis who developed RP-ILD characterized by elevated anti-CADM-140/MDA5 autoantibodies, was resistant to combined steroid and immunosuppressant therapy, and was treated successfully with PMX-DHP. To our knowledge, this is the first case to indicate a serial reduction of anti-CADM-140/MDA5 autoantibodies, associated with clinical improvement, following PMX-DHP. Early intervention using PMX-DHP may improve the prognosis of RP-ILD accompanied by CADM.

  12. Decreasing Serial Cost Sharing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Østerdal, Lars Peter

    The increasing serial cost sharing rule of Moulin and Shenker [Econometrica 60 (1992) 1009] and the decreasing serial rule of de Frutos [Journal of Economic Theory 79 (1998) 245] have attracted attention due to their intuitive appeal and striking incentive properties. An axiomatic characterization...

  13. Leni Alexander Pollack (1924-2005

    Directory of Open Access Journals (Sweden)

    Raquel Bustos Valderrama

    2007-06-01

    Full Text Available El estudio de Leni Alexander Pollack, considerada la compositora nacional más importante del siglo XX, expande y profundiza nuestro conocimiento del aporte de la mujer a la creación musical chilena. En el presente trabajo las entrevistas personales fueron no sólo la fuente primaria para obtener los antecedentes biográficos iniciales, sino también una oportunidad para discutir y aclarar asuntos de estética, tendencias y estilo. Sobre estas bases se analizan tres obras específicas, consideradas como demarcatorias de la evolución de sus recursos creativos. El catálogo de sus obras es una muestra vívida de la gran versatilidad de la compositora en el libre uso de los parámetros musicales, como elementos básicos generadores de toda una obra y, a la vez, en las sugerencias que hace a los instrumentistas- intérpretes o a los actores de su hörspiel o "teatro para escuchar". En suma, sus composiciones y escritos académicos, a los que se agrega la difusión radial comentada de la música contemporánea en Chile y en el extranjero, confirman su calidad de representante itinerante y portavoz de la vanguardia musical del siglo XXLeni Alexander Pollack, has been considered the most important national female composer of the 20th century. The study of her musical composition has contributed to further our knowledge of women's contributions to musical creation in Chile. For the present paper, personal interviews were not only a primary source for the initial biographical information, but also an opportunity to discuss with the composer topics related to aesthetics, tendencies and style. Upon these bases, three specific works are analyzed, which are considered turning points in the evolution of her creative resources. The catalog of her work is a vivid demonstration of her versatility in the free use of musical parameters, which can be seen as basic element in the generation of complete works, as well as in the suggestions she offers to the

  14. Port Alexander, Alaska Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Port Alexander, Alaska Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST) model....

  15. A Complex-Network Perspective on Alexander's Wholeness

    CERN Document Server

    Jiang, Bin

    2016-01-01

    The wholeness, conceived and developed by Christopher Alexander, is what exists to some degree or other in space and matter, and can be described by precise mathematical language. However, it remains mysterious and hard to grasp. This paper develops a complex network perspective on the wholeness to better understand the nature of order or beauty, and apply it into sustainable design. I bring together a set of complexity-science subjects such as complex networks, fractal geometry, and in particular underlying scaling hierarchy derived by head/tail breaks, in order to make Alexander's profound thoughts more accessible to design practitioners and complexity-science researchers. Through several case studies (some of which Alexander studied), I demonstrate that the complex-network perspective helps reduce the mystery of wholeness and brings new insights to Alexander's thoughts on the concept of wholeness or objective beauty in fine structures. The complex-network perspective enables us to see things in their whole...

  16. Alexander in the Tychaion: Ps.-Libanius on the Statues

    Directory of Open Access Journals (Sweden)

    Craig A. Gibson

    2010-11-01

    Full Text Available Of the statues in the precinct of Tyche in Alexandria, described by [Lib.] Ecphr. 25, the "founder" holding the token of the "Soter" is not Ptolemy I but Alexander in the guise of Zeus.

  17. Alexander’s Return to Greece in the Alexander Romance

    Directory of Open Access Journals (Sweden)

    Benjamin Garstad

    2016-11-01

    Full Text Available The ahistorical return to suppress a revolt may reflect the author’s misunderstanding of some statements in Plutarch’s De fort. Alex., as well as his desire to make Alexander the principal in every action.

  18. Geschichte der Natur bei Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Christian Helmreich

    2009-05-01

    Full Text Available Article in German, Abstracts in English, German and French.This article analyses the importance of an historical view of nature in the works of Alexander von Humboldt. In several of his first writings, Humboldt seems to outline the importance of what one may call history of nature. But even before his famous American travel, his position changed and he became reluctant to accept the seriousness of historical enquiry in the area of natural sciences: if we want to reconstruct the past state of nature, we cannot rely on empirical proofs; and history of nature is therefore necessarily based on uncertain hypotheses. Humboldt kept his sceptical attitude in the first decades of the 19th century, despite the positive results of the palaeontological researches of his scientific colleagues. However, he gradually convinced himself of the scientific interest of historical investigations in the natural sciences. The Cosmos paradoxally displays two apparently conflicting points of view: in his methodological remarks, Humboldt maintains that precise accounts of the past state of nature are out of reach of human knowledge, yet elsewhere in the same Cosmos he gives broad and rather vivid descriptions of the eventful history of nature.

  19. Disease: H00065 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00065 Alexander disease Alexander disease is a rare, but often fatal neurological ...ult forms. The characteristic neuropathological feature of all forms of Alexander's disease is the presence ...y acidic protein (GFAP) and small stress proteins in astrocytes. Neurodegenerative disease GFAP; glial fibrillary acidic protein (mutation) [HSA:2670] [KO:K05640] thyrotropin releasing hormone [DR:D00176] Disease class: leukodystrophy Affected regtion: midbrain, cerebellum Microscopic lesion: Rosenthal fibers MeSH: D038261 OMIM: 203450 PMID:17498694 Quinlan RA, Brenner M, Goldman JE, Messing A. GFAP and its role in Alexander... R, Gibbon T, Prescott AR, Brenner M, Quinlan RA The Alexander disease-causing gl... M TRH therapy in a patient with juvenile Alexander disease. Brain Dev 28:663-7 (

  20. Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG-based analysis

    Directory of Open Access Journals (Sweden)

    Sanju P Joy

    2015-01-01

    Full Text Available Purpose: We studied the sleep macroarchitecture with polysomnography (PSG in drug naïve patients with Parkinson′s disease (PD and reassessed them following treatment with levodopa. Materials and Methods: This prospective hospital-based study included 15 patients with PD (age: 59 ± 11.2 years, duration of PD: 11.8 ± 12.3 months; and male: female (M:F = 11:4. They were assessed for demography, phenotype, modified Hoehn and Yahr staging (H & Y; Schwab and England and Activities of Daily Living (S and E ADL Scale; and Unified PDRating Scale (UPDRS. Sleep was assessed using Epworth Sleepiness Scale (ESS, Pittsburgh Sleep Quality Index (PSQI, and National Institute of Mental Health and Neurosciences (NIMHANS comprehensive sleep disorder questionnaire. They underwent overnight PSG at baseline and after13.3 ± 5.7 months of levodopa (440 mg/day. Results: Patients with PD had responded to levodopa as indicated by the significant improvement in UPDRS motor score in ON state compared to OFF state. Nocturnal sleep quality indices did not vary significantly, but the excessive daytime somnolence improved (P = 0.04 with levodopa. Sleep efficiency (P = 0.65, latency to sleep onset (P = 0.19, latency to stage 1 (P = 0.12, and duration of stage 1 (P = 0.55 had increased. Duration of ′awake in bed′ (P = 0.24, slow wave sleep (P = 0.29, and rapid eye movement (REM sleep (P = 0.24 decreased with treatment. Periodic leg movements (PLMs had reduced (P = 0.68 and mean oxygen saturation during sleep improved (P = 0.002. Surprisingly, snore index (P < 0.03 during sleep had increased with levodopa. Conclusions: Sleep alterations in PD occur even in early stages due to the disease process. There was improvement in most of the parameters of sleep macroarchitecture with levodopa.

  1. Simultaneously Cooperative, but Serially Antagonistic: A Neuropsychological Study of Diagonistic Dyspraxia in a Case of Marchiafava-Bignami Disease

    Directory of Open Access Journals (Sweden)

    Kazumi Hirayama

    2008-01-01

    Full Text Available We describe a patient with Marchiafava-Bignami disease who showed, in addition to signs of callosal interruption, a peculiar form of diagonistic dyspraxia. Unlike the typical diagonistic dyspraxia, both of the patient’s hands could simultaneously cooperate in a sequence of bimanual actions. More specifically, his right hand could start a commanded action with the cooperation of his left hand. However, once the action was completed, his left hand started an antagonistic action, undoing the result, with the cooperation of his right hand. Once this countermanding action was completed, the original action started again. These antagonistic actions repeated themselves alternately unless he was restrained. The patient's diagonistic dyspraxia was apparent in only some bimanual actions, and he showed no diagonistic dyspraxia when performing voluntary actions; the antagonistic actions occurred in response to oral commands or by imitation. Magnetic resonance imaging showed symmetrical demyelination with partial necrosis in the genu, body, and anterior splenium of the corpus callosum. We speculate that the bimanual coordination is possible because part of the corpus callosum is intact, whereas the antagonistic actions may be caused by conflict between the two hemispheres due to interhemispheric disinhibition elicited by the demyelinated part of the corpus callosum.

  2. Simultaneously cooperative, but serially antagonistic: a neuropsychological study of diagonistic dyspraxia in a case of Marchiafava-Bignami disease.

    Science.gov (United States)

    Hirayama, Kazumi; Tachibana, Kaori; Abe, Nobuhito; Manabe, Hideaki; Fuse, Takahisa; Tsukamoto, Tetsuro

    2008-01-01

    We describe a patient with Marchiafava-Bignami disease who showed, in addition to signs of callosal interruption, a peculiar form of diagonistic dyspraxia. Unlike the typical diagonistic dyspraxia, both of the patient's hands could simultaneously cooperate in a sequence of bimanual actions. More specifically, his right hand could start a commanded action with the cooperation of his left hand. However, once the action was completed, his left hand started an antagonistic action, undoing the result, with the cooperation of his right hand. Once this countermanding action was completed, the original action started again. These antagonistic actions repeated themselves alternately unless he was restrained. The patient's diagonistic dyspraxia was apparent in only some bimanual actions, and he showed no diagonistic dyspraxia when performing voluntary actions; the antagonistic actions occurred in response to oral commands or by imitation. Magnetic resonance imaging showed symmetrical demyelination with partial necrosis in the genu, body, and anterior splenium of the corpus callosum. We speculate that the bimanual coordination is possible because part of the corpus callosum is intact, whereas the antagonistic actions may be caused by conflict between the two hemispheres due to interhemispheric disinhibition elicited by the demyelinated part of the corpus callosum.

  3. Classifying serial killers.

    Science.gov (United States)

    Promish, D I; Lester, D

    1999-11-01

    We attempted to match the appearance and demeanor of 27 serial killers to the postmortem 'signatures' found on their victims' bodies. Our results suggest that a link may exist between postmortem signatures and two complementary appearance-demeanor types.

  4. Serial floating point formatter

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, R. D.; Penner, W. A.

    1985-11-12

    A floating point formatter for changing fixed point serial digital data, such as that received by a seismic data acquisition system, is disclosed wherein fixed point serial digital data is received and scaled to remove any bias added by preamplification. The scaled data is shifted a predetermined number of bits and a resulting exponent is calculated. The shifted data signal and corresponding exponent are combined and further scaled to permit stacking the data without exceeding the system capacity.

  5. Finite-dimensional (*)-serial algebras

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Let A be a finite-dimensional associative algebra with identity over a field k. In this paper we introduce the concept of (*)-serial algebras which is a generalization of serial algebras. We investigate the properties of (*)-serial algebras, and we obtain suficient and necessary conditions for an associative algebra to be (*)-serial.

  6. The Windows serial port programming handbook

    CERN Document Server

    Bai, Ying

    2004-01-01

    The fundamentals of serial port communications. Serial port programming in ANSI C and Assembly languages for MS-DOS. Serial ports interface developed in VC++ 6.0. Serial port programming in Visual Basic. Serial port programming in LabVIEW. Serial port programming in MATLAB. Serial port programming in Smalltalk. Serial port programming in Java.

  7. Obituary: Donald Alexander Macrae, 1916-2006

    Science.gov (United States)

    Seaquist, E. R.

    2007-12-01

    With the passing of Donald Alexander MacRae on 6 December 2006 at age 90, the astronomy community lost a visionary scientist and a great educator in the field. Don MacRae was born in Halifax, Nova Scotia, on 19 February 1916, to Donald Alexander and Laura Geddes (Barnstead) MacRae. His father was originally a classics scholar and preceptor of Greek and Latin at Princeton, but at the time of Don's birth in 1916 he was Dean of the Dalhousie Law School in Halifax. The family moved to Toronto, Ontario, in 1924 when his father joined the faculty of Osgoode Hall Law School in Toronto as a Professor of Law. After the family moved to Toronto, where he received most of his early education, he obtained his undergraduate degree in Mathematics and Physics in 1937 from the University of Toronto (U of T). He obtained the degree of A.M. in 1940 and of Ph.D. in 1943 from Harvard University under the mentorship of Bart Bok in the field of galactic structure. During his early career he worked briefly at the University of Pennsylvania, Cornell University, and Carbide and Chemical Corporation at Oak Ridge, Tennessee. For Don the latter work was a brief and somewhat uneasy association with the Manhattan Project. In 1946, he obtained a position at Case Institute of Technology (now Case Western Reserve University), where he worked until 1953. In 1953, he accepted a position at the U of T, replacing Ralph Williamson, who had earlier introduced Don to the emerging field of radio astronomy while they both were at Cornell. Don's primary research field was stellar spectroscopy, but his interests were much broader than this, and he possessed an abiding ability to interest students and faculty in new and emerging ideas. In the early 1960s he developed a strong interest in the nature and origin of the lunar surface, and discussed these extensively with colleagues. Many of his ideas on this subject were later confirmed by the lunar exploration program. Don's continuing interest in radio astronomy

  8. Obituary: Walter Alexander Feibelman, 1930-2004

    Science.gov (United States)

    Oergerle, William

    2005-12-01

    Walter Alexander Feibelman, 79, an astronomer who discovered the E-ring of Saturn, died of a heart attack 19 November 2004 at his home at Riderwood Village in Silver Spring, Maryland. Walter was born 30 October 1925 in Berlin, Germany to Bernard and Dora Feibelman. He came to the United States with his parents in 1941. They were some of the last German Jews to flee Nazi Germany. Years later, he reported his experiences in an account contributed to the U.S. Holocaust Memorial Museum. As a youth, he worked at a cleaning shop and as a soda jerk before taking a course in tool and die making. He worked at the Abbey Photo Corp. in New York and in a model-making firm, where he constructed models of aircraft for use in identification courses by the Army Air Forces. After high school, he attended the Carnegie Institute of Technology and received his BS degree in 1956. Until 1969, he was a research scientist at the University of Pittsburgh. While working as an assistant research professor in physics and astronomy at the University of Pittsburgh in 1967, he examined a photo of Saturn taken a year earlier at the university's Allegheny Observatory. The E-ring -- unlike the bright main rings, A, B, C, D and F -- is faint and not easily spotted. He paired his observation with calculations and announced his discovery, which remained unconfirmed until the Pioneer 11 flyby in 1979. Walter joined the Optical Astronomy Division of Goddard Space Flight Center in Greenbelt in 1969, and worked there until 2002, when he became an emeritus astronomer at NASA. He became associated with the International Ultraviolet Explorer project, and worked on developing detectors for the orbiting observatory's spectrograph. The project turned out to be one of NASA's most successful observatories, operating from 1978 to 1996. In his scientific career, he published more than 200 refereed articles, mainly on hot stars and planetary nebulae. He also wrote papers in the fields of photography, spectroscopy

  9. Plasma exchange combined with azathioprine in multiple sclerosis using serial gadolinium-enhanced MRI to monitor disease activity: a randomized single-masked cross-over pilot study

    DEFF Research Database (Denmark)

    Sørensen, P.S.; Wanscher, B; Szpirt, W;

    1996-01-01

    the whole trial, and three patients discontinued the trial, two during the run-in period of azathioprine treatment and one at the introduction of PE. The primary efficacy variables were the number of gadolinium-enhancing lesions and the occurrence of new enhancing lesions on serial MRI performed every 3...

  10. Scientific Serial Lists

    Directory of Open Access Journals (Sweden)

    Dana L. Roth

    1972-03-01

    Full Text Available This article describes the need for user-oriented serial lists and the development of such a list in the California Institute of Technology library. The results of conversion from EAM to EDP equipment and subsequent utilization of COM (Computer-Output-Microfilm is reported.

  11. Selection and Serial Entrepreneurs

    DEFF Research Database (Denmark)

    Chen, Jing

    2011-01-01

    Although it has been broadly evidenced that entrepreneurial experience plays a substantial role in the emergence of serial entrepreneurship, the debate is still going on about whether this relationship should be attributed to learning by doing or instead be explained by selection on ability. This...

  12. Selection and Serial Entrepreneurs

    DEFF Research Database (Denmark)

    Chen, Jing

    2013-01-01

    There is substantial evidence that serial entrepreneurs outperform de novo entrepreneurs. But is this positive association between prior experience and performance the result of learning by doing or of selection on ability? This paper proposes a strategy that combines the fixed-effects model and IV...... when the analysis focuses on founding new startups in sectors closely related to entrepreneurs' previous ventures....

  13. Second premolar serial extraction.

    Science.gov (United States)

    Joondeph, D R; Riedel, R A

    1976-02-01

    Serial extraction of mandibular second premolars should be considered if they are impacted or in cases with moderate arch length deficiency combined with an absence of dentofacial protrusion. The favorable dental changes associated with this approach greatly minimize future orthodontic treatment complexity and time.

  14. Suicide in serial killers.

    Science.gov (United States)

    Lester, David; White, John

    2010-02-01

    In a sample of 248 killers of two victims in America from 1900 to 2005, obtained from an encyclopedia of serial killers by Newton (2006), those completing suicide did not differ in sex, race, or the motive for the killing from those who were arrested.

  15. A complex-network perspective on Alexander's wholeness

    Science.gov (United States)

    Jiang, Bin

    2016-12-01

    The wholeness, conceived and developed by Christopher Alexander, is what exists to some degree or other in space and matter, and can be described by precise mathematical language. However, it remains somehow mysterious and elusive, and therefore hard to grasp. This paper develops a complex network perspective on the wholeness to better understand the nature of order or beauty for sustainable design. I bring together a set of complexity-science subjects such as complex networks, fractal geometry, and in particular underlying scaling hierarchy derived by head/tail breaks - a classification scheme and a visualization tool for data with a heavy-tailed distribution, in order to make Alexander's profound thoughts more accessible to design practitioners and complexity-science researchers. Through several case studies (some of which Alexander studied), I demonstrate that the complex-network perspective helps reduce the mystery of wholeness and brings new insights to Alexander's thoughts on the concept of wholeness or objective beauty that exists in fine and deep structure. The complex-network perspective enables us to see things in their wholeness, and to better understand how the kind of structural beauty emerges from local actions guided by the 15 fundamental properties, and in particular by differentiation and adaptation processes. The wholeness goes beyond current complex network theory towards design or creation of living structures.

  16. Bemerkungen zu Alexander von Humboldts Russland-Tagebuch

    Directory of Open Access Journals (Sweden)

    Petra Werner

    2008-04-01

    Full Text Available Article in German, Abstracts in English and GermanIn this study the fragment of Alexander von Humboldt’s Siberian personal diary of 1829 is introduced. The evaluation is focussed on Humboldt’s remarks about mineral resources, especially gold and diamonds. Also mentioned are results which Humboldt recorded about geographical, botanical, meteorological, zoological and ethnological questions.

  17. Alexander von Humboldt als astronomischer Arbeiter, Diskussionspartner und Ideengeber

    Directory of Open Access Journals (Sweden)

    Oliver Schwarz

    2014-12-01

    Full Text Available Auf welche Weise sich unsere Einschätzung des wissenschaftlichen Wirkens Alexander von Humboldts auf Grundlage der beständig voranschreitenden Erschließung seiner Handschriften verändern konnte und welche aktuellen wissenschaftshistorischen Fragestellungen dadurch aufgeworfen wurden, verdeutlicht Oliver Schwarz an Beispielen aus der Astronomie.

  18. Alexander Meiklejohn in Search of Freedom and Dignity.

    Science.gov (United States)

    Johnson, Tony W.

    1982-01-01

    Assesses the contributions of the philosopher/educator Alexander Meiklejohn. Discusses the influences of Jean-Jacques Rousseau, Immanuel Kant, and the U.S. Constitution on Meiklejohn's educational theories, which stressed that human freedom and dignity can be enhanced by rigorous examination of U.S. Supreme Court decisions and the meaning of…

  19. Journalism and the Educational Views of Alexander Meiklejohn.

    Science.gov (United States)

    Palmer, Mack R.

    Alexander Meiklejohn, who died in 1964 at the age of 92, was a constitutional scholar whose major interest was education. Among Meiklejohn's beliefs were the following: the social good should take precedence over individual achievement; the liberal arts college is the institution best suited to carry out an affirmative reading of the First…

  20. Krahv Alexander von Keyserling / Sirje Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Sirje, 1947-

    2002-01-01

    Alexander Friedrich Michael Lebrecht Arthur Nicolaus James von Keyserlingi (1815-1891) elust ja teaduslikest ekspeditsioonidest Venemaal ning tegevusest Eestis Raikküla mõisnikuna, loodusteadlasena, Eestimaa rüütelkonna peamehena, eesti talupoegade olukorra parandajana, Tartu õpperingkonna kuraatorina, maanõunikuna, tema pereelust ja lastest

  1. The Making of the Liberal College: Alexander Meiklejohn at Amherst.

    Science.gov (United States)

    Brennan, Robert Thomas

    1988-01-01

    Surveys the history and curricular changes of Amherst College from its founding in 1821 through the administration of Alexander Meiklejohn in 1912. Assesses Meiklejohn's impact upon the development of Amherst as a liberal arts college, and analyses the events surrounding his dismissal. (SLM)

  2. Delaware's first serial killer.

    Science.gov (United States)

    Inguito, G B; Sekula-Perlman, A; Lynch, M J; Callery, R T

    2000-11-01

    The violent murder of Shirley Ellis on November 29, 1987, marked the beginning of the strange and terrible tale of Steven Bryan Pennell's reign as the state of Delaware's first convicted serial killer. Three more bodies followed the first victim, and all had been brutally beaten and sadistically tortured. The body of a fifth woman has never been found. State and county police collaborated with the FBI to identify and hunt down their suspect, forming a task force of over 100 officers and spending about one million dollars. Through their knowledge and experience with other serial killers, the FBI was able to make an amazingly accurate psychological profile of Delaware's serial killer. After months of around-the-clock surveillance, Steven Pennell was arrested on November 29, 1988, one year to the day after the first victim was found. Pennell was found guilty in the deaths of the first two victims on November 29, 1989, and plead no contest to the murder of two others on October 30, 1991. Still maintaining his innocence, he asked for the death penalty so that he could spare his family further agony. Steven Pennell was executed by lethal injection on March 15, 1992.

  3. Alexander von Humboldt and the Beginning of the Environmental Movement

    Directory of Open Access Journals (Sweden)

    Engelhard Weigl

    2001-04-01

    Full Text Available Article in English, Abstracts in English and German.In the middle of the 19th century the question whether expanding civilization and industrialization had an effect on climate was discussed intensely worldwide. It was feared that increasing deforestation would lead to continuous decrease in rainfall. This first scientific discussion about climate change as the result of human intervention was strongly influenced by the research Alexander von Humboldt and Jean-Baptiste Boussingault had undertaken when they investigated the falling water levels of Lake Valencia in Venezuela. This essay aims to clarify the question whether Alexander von Humboldt can be counted among the leading figures of modern environmentalism on account of this research as is being claimed by Richard H. Grove in his influential book Green Imperialism. Colonial Expansion, Tropical Island Edens and Origins of Environmentalism, 1600-1860 (1995.

  4. Prof. Alexander Strunnikov: Drug Discovery Opportunities Lead Me to China

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    After working for NIH for more than 3.6 years as microorganism genetics expert, in late 203.3-, Alexander Strunnikov joined the CAS Guangzhou Institutes of Biomedicine and Health (GIBH) and embarked on cancer research that had enticed him for quite a few years. As he mentioned, the successful application of the RPFE grant has played a key role, and that he needed only minor lifestyle adjustments to facilitate his work in Guangzhou.

  5. Increased dynamic regulation of postural tone through Alexander Technique training

    OpenAIRE

    Cacciatore, TW; Gurfinkel, VS; Horak, FB; Cordo, PJ; Ames, KE

    2010-01-01

    Gurfinkel and colleagues (2006) recently found that healthy adults dynamically modulate postural muscle tone in the body axis during anti-gravity postural maintenance and that this modulation is inversely correlated with axial stiffness. Our objective in the present study was to investigate whether dynamic modulation of axial postural tone can change through training. We examined whether teachers of the Alexander Technique (AT), who undergo “long-term” (3-year) training, have greater modulati...

  6. Cocycle Knot Invariants, Quandle Extensions, and Alexander Matrices

    OpenAIRE

    2002-01-01

    The theory of quandle (co)homology and cocycle knot invariants is rapidly being developed. We begin with a summary of these recent advances. One such advance is the notion of a dynamical cocycle. We show how dynamical cocycles can be used to color knotted surfaces that are obtained from classical knots by twist-spinning. We also demonstrate relations between cocycle invariants and Alexander matrices.

  7. The Old Serbian Alexander Romance and the Greek Phyllada

    Directory of Open Access Journals (Sweden)

    Krzysztof Usakiewicz

    2014-12-01

    Full Text Available The paper includes a short introduction and four excerpts from the Old Serbian Alexander Romance translated into Polish by Maciej Falski.   Tekst zawiera krótką prezentację zagadnienia filiacji Opowieści o Aleksandrze w bałkańskiej przestrzeni kulturowej oraz przekład fragmentów tzw. Serbskiej Aleksandreidy na język polski.

  8. Serially Concatenated IRA Codes

    CERN Document Server

    Cheng, Taikun; Belzer, Benjamin J

    2007-01-01

    We address the error floor problem of low-density parity check (LDPC) codes on the binary-input additive white Gaussian noise (AWGN) channel, by constructing a serially concatenated code consisting of two systematic irregular repeat accumulate (IRA) component codes connected by an interleaver. The interleaver is designed to prevent stopping-set error events in one of the IRA codes from propagating into stopping set events of the other code. Simulations with two 128-bit rate 0.707 IRA component codes show that the proposed architecture achieves a much lower error floor at higher SNRs, compared to a 16384-bit rate 1/2 IRA code, but incurs an SNR penalty of about 2 dB at low to medium SNRs. Experiments indicate that the SNR penalty can be reduced at larger blocklengths.

  9. Provintsist pärit IT-mõtleja / Alexander Galitsky ; interv. Viktoria Korpan

    Index Scriptorium Estoniae

    Galitsky, Alexander

    2005-01-01

    Venemaa tuntumaid info- ja kõrgtehnoloogiavaldkonna spetsialiste infotehnoloogiast ja selle erinevatest võimalustest, tehnoloogia lahendustest ning avastustest, turvaprobleemidest. Lisa: Alexander Galitsky

  10. Le fonds Alexander Walker de la Cineteca di Friouli

    OpenAIRE

    Codelli, Lorenzo

    2012-01-01

    La Collection Alexander Walker conservée à la Bibliothèque Angelo R. Humouda de la Cineteca del Friuli, à Gemona, Italie, inclût le patrimoine libraire entier, ainsi que la correspondence et tous les manuscripts d’un des critiques et essayistes anglosaxons les plus connus et influents de sa génération. Ses polémiques contre la censure, sa collaboration avec Stanley Kubrick pour la toute première monographie parue sur l’auteur de 2001 : L’Odyssée de l’espace, ses recherches fouillées sur Josep...

  11. Alexander Skutch: Naturalista Y Filósofo

    OpenAIRE

    Mata Jiménez, Alfonso

    2013-01-01

    El artículo considera la figura de Alexander Skutch como el hombre de ciencia que analiza el entorno natural y la relación de las personas con este entorno, desde una perspectiva humanista. Su vida y sus ideas de vivir en armonía con la naturaleza son sumamente significativas hoy por las acciones humanas que ponen en peligro la estabilidad de la naturaleza. Se discurre sobre la forma como Skutch procura su conocimiento y convivencia con la naturaleza sin causarle daño y de sus ideas de cómo e...

  12. Reluctant genius Alexander Graham Bell and the passion for invention

    CERN Document Server

    Gray, Charlotte

    2011-01-01

    The popular image of Alexander Graham Bell is that of an elderly American patriarch, memorable only for his paunch, his Santa Claus beard, and the invention of the telephone. In this magisterial reassessment based on thorough new research, acclaimed biographer Charlotte Gray reveals Bell's wide-ranging passion for invention and delves into the private life that supported his genius. The child of a speech therapist and a deaf mother, and possessed of superbly acute hearing, Bell developed an early interest in sound. His understanding of how sound waves might relate to electrical waves enabled h

  13. Bildnisse mit Berg: Goethe und Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Renato Giuseppe Mazzolini

    2004-04-01

    Full Text Available Article in German, translated by Wolfgang Böker, Abstracts in English and GermanBoth Alexander von Humboldt and Johann Wolfgang von Goethe have been portrayed in their later years anachronistically before the background of a mountain that had been of high significance in their earlier biography and carreer. For Goethe this was the Vesuvio, and for Humboldt the Chimborazo. This paper examines the numerous conceptual and formal parallels between the two paintings which make it probable that the Goethe portrait served as a blueprint for the portrait of Humboldt.

  14. Stiffness of serial and quasi-serial manipulators: comparison analysis

    Directory of Open Access Journals (Sweden)

    Klimchik Alexandr

    2016-01-01

    Full Text Available The paper deals with comparison analysis of serial and quasi-serial manipulators. It shows a difference between stiffness behaviours of corresponding industrial robots under external loading, which is caused by machining process. The analysis is based on the estimation of compliance errors induced by cutting forces that are applied to the manipulator end-effector. We demonstrate that the quasi-seral manipulators are preferable for large-dimensional tasks while the quasi-serial ones better suit small size tasks.

  15. Short-term genome stability of serial Clostridium difficile ribotype 027 isolates in an experimental gut model and recurrent human disease.

    Directory of Open Access Journals (Sweden)

    David W Eyre

    Full Text Available BACKGROUND: Clostridium difficile whole genome sequencing has the potential to identify related isolates, even among otherwise indistinguishable strains, but interpretation depends on understanding genomic variation within isolates and individuals. METHODS: Serial isolates from two scenarios were whole genome sequenced. Firstly, 62 isolates from 29 timepoints from three in vitro gut models, inoculated with a NAP1/027 strain. Secondly, 122 isolates from 44 patients (2-8 samples/patient with mostly recurrent/on-going symptomatic NAP-1/027 C. difficile infection. Reference-based mapping was used to identify single nucleotide variants (SNVs. RESULTS: Across three gut model inductions, two with antibiotic treatment, total 137 days, only two new SNVs became established. Pre-existing minority SNVs became dominant in two models. Several SNVs were detected, only present in the minority of colonies at one/two timepoints. The median (inter-quartile range [range] time between patients' first and last samples was 60 (29.5-118.5 [0-561] days. Within-patient C. difficile evolution was 0.45 SNVs/called genome/year (95%CI 0.00-1.28 and within-host diversity was 0.28 SNVs/called genome (0.05-0.53. 26/28 gut model and patient SNVs were non-synonymous, affecting a range of gene targets. CONCLUSIONS: The consistency of whole genome sequencing data from gut model C. difficile isolates, and the high stability of genomic sequences in isolates from patients, supports the use of whole genome sequencing in detailed transmission investigations.

  16. Short-Term Genome Stability of Serial Clostridium difficile Ribotype 027 Isolates in an Experimental Gut Model and Recurrent Human Disease

    Science.gov (United States)

    Eyre, David W.; Walker, A. Sarah; Freeman, Jane; Baines, Simon D.; Fawley, Warren N.; Chilton, Caroline H.; Griffiths, David; Vaughan, Alison; Crook, Derrick W.; Peto, Tim E. A.; Wilcox, Mark H.

    2013-01-01

    Background Clostridium difficile whole genome sequencing has the potential to identify related isolates, even among otherwise indistinguishable strains, but interpretation depends on understanding genomic variation within isolates and individuals. Methods Serial isolates from two scenarios were whole genome sequenced. Firstly, 62 isolates from 29 timepoints from three in vitro gut models, inoculated with a NAP1/027 strain. Secondly, 122 isolates from 44 patients (2–8 samples/patient) with mostly recurrent/on-going symptomatic NAP-1/027 C. difficile infection. Reference-based mapping was used to identify single nucleotide variants (SNVs). Results Across three gut model inductions, two with antibiotic treatment, total 137 days, only two new SNVs became established. Pre-existing minority SNVs became dominant in two models. Several SNVs were detected, only present in the minority of colonies at one/two timepoints. The median (inter-quartile range) [range] time between patients’ first and last samples was 60 (29.5–118.5) [0–561] days. Within-patient C. difficile evolution was 0.45 SNVs/called genome/year (95%CI 0.00–1.28) and within-host diversity was 0.28 SNVs/called genome (0.05–0.53). 26/28 gut model and patient SNVs were non-synonymous, affecting a range of gene targets. Conclusions The consistency of whole genome sequencing data from gut model C. difficile isolates, and the high stability of genomic sequences in isolates from patients, supports the use of whole genome sequencing in detailed transmission investigations. PMID:23691061

  17. 76 FR 28226 - Ndahendekire Barbara v. African Shipping; Njoroge Muhia; Alco Logistics, Llc; Brenda Alexander...

    Science.gov (United States)

    2011-05-16

    ... Ndahendekire Barbara v. African Shipping; Njoroge Muhia; Alco Logistics, Llc; Brenda Alexander; and AIR 7 Seas... ``Complainant,'' against African Shipping; Njoroge Muhia, ALCO Logistics, LLC; Brenda Alexander; and Air 7 Seas Transport Logistics, Inc.; hereinafter ``Respondents''. Complainant asserts that she is acting agent...

  18. Kinesthetic Ventures Informed by the Work of F. M. Alexander, Stanislavski, Peirce, and Freud.

    Science.gov (United States)

    Bouchard, Ed; Wright, Ben; Protzel, Michael, Ed.

    This book is about education harvested from self-observation. F. Matthias Alexander (1869-1955) studied the experience of self formation, working with motor habits. His method is used in performing arts training to enhance bodily and vocal expression. Like Alexander, Konstantine Stanislavski (1863-1938) and Sigmund Freud (1856-1939) studied human…

  19. Whole rice bran for beef heifers raised on alexander grass pasture

    Directory of Open Access Journals (Sweden)

    P. R. Salvador

    2016-09-01

    Full Text Available The objective of this study was to evaluate the development of beef heifers exclusively fed alexander grass (Urochloa plantaginea (Link Hitch or alexander grass and whole rice meal as supplement offered from Monday to Friday. The experimental design was completely randomized, with repeated measures over time, and consisted of two treatments and three replications of area. Heifers receiving whole rice meal exhibited higher average daily gain after day 42 of pasture use and a 21% higher body weight at the end of the grazing period. The stocking rate, weight gain per area, hip height, weight-height ratio, and body condition score were similar for heifers exclusively fed alexander grass and alexander grass plus rice bran. Beef heifers raised exclusively on alexander grass from 15 to 18 months of age reached adequate body development, reproductive tract score (4.22 points and pelvic area (206.3 cm² to be bred at 18-20 months of age.

  20. Serial Input Output

    Energy Technology Data Exchange (ETDEWEB)

    Waite, Anthony; /SLAC

    2011-09-07

    Serial Input/Output (SIO) is designed to be a long term storage format of a sophistication somewhere between simple ASCII files and the techniques provided by inter alia Objectivity and Root. The former tend to be low density, information lossy (floating point numbers lose precision) and inflexible. The latter require abstract descriptions of the data with all that that implies in terms of extra complexity. The basic building blocks of SIO are streams, records and blocks. Streams provide the connections between the program and files. The user can define an arbitrary list of streams as required. A given stream must be opened for either reading or writing. SIO does not support read/write streams. If a stream is closed during the execution of a program, it can be reopened in either read or write mode to the same or a different file. Records represent a coherent grouping of data. Records consist of a collection of blocks (see next paragraph). The user can define a variety of records (headers, events, error logs, etc.) and request that any of them be written to any stream. When SIO reads a file, it first decodes the record name and if that record has been defined and unpacking has been requested for it, SIO proceeds to unpack the blocks. Blocks are user provided objects which do the real work of reading/writing the data. The user is responsible for writing the code for these blocks and for identifying these blocks to SIO at run time. To write a collection of blocks, the user must first connect them to a record. The record can then be written to a stream as described above. Note that the same block can be connected to many different records. When SIO reads a record, it scans through the blocks written and calls the corresponding block object (if it has been defined) to decode it. Undefined blocks are skipped. Each of these categories (streams, records and blocks) have some characteristics in common. Every stream, record and block has a name with the condition that each

  1. Roger Bacon in der Sicht Alexander von Humboldts

    Directory of Open Access Journals (Sweden)

    Tom Müller

    2008-10-01

    Full Text Available Articel in german, abstracts in englisch, german and español In his model of the six epochs of the history of science, Alexander von Humboldt sees scarcely any lights able to break through the occidental darkness in the time between the scientific prime of the arabic world and the expeditions of Columbus. The most prominent of these few pioneers to Humboldt is the fransciscan monc Roger Bacon who excelled in almost all disciplines and emphasized on the unity of the sciences. Humboldt honors the Englishman with detailed examinations of his Opus maius in Kosmos and also in his popular speeches in the Berlin Singakademie as well as in the examen critique on the history of geography of the New World.

  2. Silurian Gastropoda from the Alexander terrane, southeast Alaska

    Science.gov (United States)

    Rohr, D.M.; Blodgett, R.B.

    2008-01-01

    Gastropods are described from Ludlow-age strata of the Heceta Limestone on Prince of Wales Island, southeast Alaska. They are part of a diverse megabenthic fauna of the Alexander terrane, an accreted terrane of Siberian or Uralian affinities. Heceta Limestone gastropods with Uralian affinities include Kirkospira glacialis, which closely resembles "Pleurotomaria" lindstromi Oehlert of Chernyshev, 1893, Retispira cf. R. volgulica (Chernyshev, 1893), and Medfracaulus turriformis (Chernyshev, 1893). Medfracaulus and similar morphotypes such as Coelocaulus karlae are unknown from rocks that are unquestionably part of the North American continent (Laurentia) during Late Silurian time. Beraunia is previously known only from the Silurian of Bohemia. Pachystrophia has previously been reported only from western North American terranes (Eastern Klamath, York, and Farewell terranes) and Europe. Bathmopterus Kirk, 1928, is resurrected and is only known from the Silurian of southeast Alaska. Newly described taxa include Hecetastoma gehrelsi n. gen. and n. sp. and Baichtalia tongassensis n. gen. and n. sp. ??2008 The Geological Society of America.

  3. Hypertextuality in the Alexander von Humboldt Digital Library

    Directory of Open Access Journals (Sweden)

    Detlev Doherr

    2016-04-01

    Full Text Available To do justice to the legacy of Alexander von Humboldt, a 19th century German scientist and explorer an information and knowledge management system is required to preserve the author's original intent and promote an awareness of all his relevant works. Although all of Humboldt's works can be found on the internet as digitized papers, the complexity and internal interconnectivity of the writings is not very transparent. Humboldt's concepts of interaction cannot be adequately represented only by digitized papers or scanned documents. The Humboldt Portal is an attempt to create a new generation of digital libraries, providing a new form of interaction and synthesis between humanistic texts and scientific observation. The digital version of his documents supplies dynamic links to sources, maps, images, graphs and relevant texts in accordance with his visions, because "everything is interconnectedness".

  4. Alexander v. Sandoval:A Setback for Civil Rights

    Directory of Open Access Journals (Sweden)

    Kevin G. Welner

    2001-06-01

    Full Text Available This article confronts the serious implications of a recent U.S. Supreme Court decision, Alexander v. Sandoval, which eliminated an important legal avenue for civil rights plaintiffs. For over 35 years, individuals have been allowed to bring lawsuits directly challenging violations of rights set forth in the federal regulations implementing Title VI of the 1964 Civil Rights Act. Because these actions could be grounded in proof of disparate impact, rather than discriminatory intent, they allowed for some claims that could not go forward under other legal authorities, such as the Fourteenth Amendment. While the author concludes by identifying key remaining options, he highlights the real damage done by this decision.

  5. THE EARLY LYRICS BY ALEXANDER BLOK IN ARABIC TRANSLATIONS

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    A. A. ABDULRAZZAK AHMED

    2015-01-01

    Full Text Available In this article the author discusses the features of the early poetry of Alexander Blok, which found response in the hearts of Arab readers thanks to translations into the Arabic language. The professionalism of translators allowed to reveal the deep hidden meaning in the content of the poems. Many Arab experts translated the poems by Alexander Blok. The first translations of Blok’s poems into the Arabic language were made in the beginning of the 20th century. Arabs, who studied in Europe, translated Blok’s poems from the European languages into Arabic. For example, S. Tewfik translated “The Lady Unknown” (“Neznakomka”, 1906 from the French language, and after that many Arabic specialists translated Blok’s poems: H. Lutfi, the Egyptian writer and translator from Russian, familiarized Arabic readers with the cycle of poetry “The Verses about the Beautiful Lady” (1904, which he titled “The Poet in Love”. Saleh bin Ali Al-Hammadi, Abu Elshaar, Faleh Al- Humrani and Abu-Bark Yussef also translated “The Verses about the Beautiful Lady” and such famous poems as “Cleopatra”, “The Lady Unknown”, “The Twelve”. Moreover, there are several different translations of “The Lady Unknown” and “The Twelve”. The article analyzes the translations of the first Blok’s collection of poems “The Verses about the Beautiful Lady” made by Sabri Tafud in 1985.

  6. [Serial episodes of gastric and cecal perforation in a patient with Behcet's disease involving the whole gastrointestinal tract: a case report].

    Science.gov (United States)

    Shin, Dong Yeob; Cheon, Jae Hee; Park, Jae Jun; Kim, Hoguen; Kim, Tae Il; Lee, Yong Chan; Kim, Nam Kyu; Kim, Won Ho

    2009-02-01

    Behcet's disease (BD) has been recognized as multi-systemic chronic vasculitic disorder of recurrent inflammation, characterized by the involvement of multiple organs and resulting in orogenital ulcers, uveitis, and skin lesions. Involvement of the central nervous system, vessels, and intestines in BD often leads to a poor prognosis. Digestive manifestations in BD have been reported in up to 1-60% of cases, although the rate varies in different countries. The most frequent extra-oral sites of gastrointestinal involvement are the ileocecal region and the colon. Gastric or esophageal involvement is reported to be very rare. Moreover, there have been no reports on the simultaneous involvement of the esophagus, stomach, ileum, and colon. Here, we present a 55-year-old Korean man with intestinal BD and multiple ileal and colonic ulcerations complicated by perforation, gastric ulcer with bleeding followed by perforation, and esophageal ulcers with bleeding.

  7. La pasión de Alexander Crichton

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    Matusevich, Daniel

    2015-12-01

    Full Text Available Alexander Crichton was born in Edinburgh in 1763; he graduated from Leyden University and travelled through Berlín, Paris, Stuttgart, Prague and Gotinga to perfect his knowledge in medicine while he establish a deep connection between the social media and the culture of those places. On 1798 he published An inquiry into the nature and origin of Mental Derangement, the only book he wrote dedicated to madness. In this paper we review some questions referred to the general method that the author applies, his contributions to the semiotics of the mind and to the analysis of the process of aging and the function of the attention; we also take a look to his conception of the world of passions and of madness, who influenced Philippe Pinel and Dominique Esquirol and also constitute a cornerstone in the birth of psychiatry.Alexander Crichton, nació en Edimburgo en 1763, se graduó en la Universidad de Leyden y completó su formación médica en Berlín, Paris, Stuttgart, Praga y Gotinga, vinculándose estrechamente con el ambiente social y cultural de esos prestigiosos centros europeos. En el año 1798 publicó An Inquiry into the nature and origin of Mental Derangement (Investigación sobre la naturaleza y el origen del trastorno mental, única obra de su autoría dedicada a la locura. En este artículo se analizan algunas cuestiones referidas al método general que aplica el autor para la concepción de su obra, sus contribuciones a la semiología de la mente, al análisis del proceso de envejecimiento y a la función de la atención, para detenernos, finalmente, en su conceptuación del mundo de las pasiones y de la locura que fueron retomadas por otros autores como Philippe Pinel y Dominique Esquirol, y que constituyeron un antecedente fundamental en el nacimiento de la psiquiatría.

  8. THE IMAGE OF THE TSAR ABANDONING HIS THRONE IN ALEXANDER PUSHKIN'S POETRY

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    Lebedeva E. S.

    2008-11-01

    Full Text Available The article analyses the image of the Tzar, who abandoned his family name, throne and crown and hid to repent his sins, created by Alexander Pushkin in his poems "Angelo" and "Roderick".

  9. The Berlin tradition in Chicago: Franz Alexander and the Chicago Institute for Psychoanalysis.

    Science.gov (United States)

    Schmidt, Erika S

    2010-01-01

    Freud considered Franz Alexander, the first graduate of the Berlin Psychoanalytic Institute and an assistant in the Berlin Polyclinic, to be "one of our strongest hopes for the future." Alexander went on to become the first director of the Chicago Institute for Psychoanalysis in 1932 and modeled some of the Chicago Institute's mission on his Berlin experiences. He was also a researcher in psychosomatic medicine, a prolific writer about psychoanalysis and prominent in psychoanalytic organizations. As he proposed modifications in psychoanalytic technique, he became a controversial figure, especially in the elaboration of his ideas about brief therapy and the corrective emotional experience. This paper puts Alexander's achievements in historical context, draws connections between the Berlin and Chicago Institutes and suggests that, despite his quarrels with traditional psychoanalysis, Alexander's legacy may be in his attitude towards psychoanalysis, characterized by a commitment to scientific study, a willingness to experiment, and a conviction about the role of psychoanalysis within the larger culture.

  10. Siim Nestor soovitab : Ben Frost ja Alexander Robotnik Eclectical / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2007-01-01

    Austraalia muusik ja helilooja Ben Frost projektiga "6 guitars" esinemas festivali Eclectica raames 6. sept. Tartu klubis Rock ja Roll ja itaalia diskor Alexander Robotnik 7. sept. klubis Trehv, esinejatest

  11. Use of serial assessment of disease severity and liver biopsy for indication for liver transplantation in pediatric Epstein-Barr virus-induced fulminant hepatic failure.

    Science.gov (United States)

    Nakazawa, Atsuko; Nakano, Natsuko; Fukuda, Akinari; Sakamoto, Seisuke; Imadome, Ken-Ichi; Kudo, Toyoichiro; Matsuoka, Kentaro; Kasahara, Mureo

    2015-03-01

    The decision to perform liver transplantation (LT) in patients with Epstein-Barr virus (EBV)-induced fulminant hepatic failure (FHF) relies on a precise assessment of laboratory and pathological findings. In this study, we analyzed clinical and laboratory data as well as the pathological features of the liver in order to evaluate the pathogenesis and the need for LT in 5 patients with EBV-induced FHF. According to the King's College criteria, the Acute Liver Failure Early Dynamic (ALFED) model, and the Japanese criteria (from the Acute Liver Failure Study Group of Japan), only 1 patient was considered to be a candidate for LT. However, explanted liver tissues in 3 cases exhibited massive hepatocellular necrosis together with diffuse CD8-positive T cell infiltration in both the portal area and the sinusoid. EBV was detected in the liver, plasma, and peripheral blood mononuclear cells (PBMNCs). In 2 cases indicated to be at moderate risk by the ALFED model, liver biopsy showed CD8-positive and EBV-encoded RNA signal-positive lymphocytic infiltration predominantly in the portal area, but massive hepatocellular necrosis was not observed. These patients were treated with immunosuppressants and etoposide under the diagnosis of EBV-induced hemophagocytic lymphohistiocytosis or systemic EBV-positive T cell lymphoproliferative disease of childhood. EBV DNA was detected at a high level in PBMNCs, although it was negative in plasma. On the basis of the pathological analysis of the explanted liver tissues, LT was proposed for the restoration of liver function and the removal of the EBV-infected lymphocytes concentrated in the liver. Detecting EBV DNA by a quantitative polymerase chain reaction in plasma and PBMNCs was informative. An accurate evaluation of the underlying pathogenesis is essential for developing a treatment strategy in patients with EBV-induced FHF.

  12. Alexander von Humboldt und die transnationale Wissenschaftskommunikation im 19. Jahrhundert

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    Ulrich Päßler

    2008-10-01

    Full Text Available Article in german, abstracts in english and frenchAlexander von Humboldt has been labelled a “scientific cosmopolitan”. Through his vast correspondence and a network of personal contacts, he upheld a form of scientific exchange that was characteristic of the eighteenth-century “republic of letters”.This article examines how Humboldt adapted this cosmopolitan tradition of communication to a nineteenth century scientific culture that was largely institutionalized and was becoming increasingly nationalized. Humboldt quite successfully fostered scientific exchange between Berlin and Paris after 1830 and, on various occasions between the 1830s and 1850s, readily advocated international large-scale projects. These examples demonstrate that Humboldt observed the development of nationally defined scientific cultures and the opening of the sciences towards the public realm. Moreover, they indicate how he was able to make use of these developments as he promoted the sciences in Prussia. In scientific controversies within the Parisian scientific community, Humboldt was involuntarily assigned the role of a “neutral” foreign arbitrator. Thus, the development of nineteenth century sciences also jeopardized Humboldt’s unique position as an independent “homme des lettres”.

  13. Alexander's and Phoebe's stars: Two New Exotic Phoenix Giants

    Science.gov (United States)

    Melis, Carl; Zuckerman, B.; Song, I.; Rhee, J. H.; Bessell, M. S.; Murphy, S. J.

    2011-01-01

    Phoenix Giants are first-ascent giant stars orbited by substantial dusty and gaseous disks that are sometimes accreting onto the central star. We present the characterization of two dusty first-ascent giant stars identified through cross-correlating the Tycho-2 and IRAS catalogs. CD-30 11814 (hereafter Alexander's star) is a high-velocity Pop II star that exhibits rapid accretion and outflowing gas. Multiple epochs of spectroscopic observations show that the double-peaked Ca II infrared triplet emission from this source has variable morphology and strength. TYC 596 145 1 (hereafter Phoebe's star) is a lithium-rich K2.5 III star orbited by a substantial icy disk as indicated by water-ice features detected in Spitzer IRS and IRTF/SpeX infrared spectroscopy. Each source can yield interesting insights into binary star evolution and planetary systems. Funding for this research came from NASA grants and an LLNL-Minigrant to UCLA and from the Spitzer Visiting Graduate Student Program.

  14. Spurensuche einer Rezeptionsgeschichte Alexander von Humboldt und Johann Gottfried Herder

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    Bernhard Hunger

    2009-05-01

    Full Text Available Article in German, Abstracts in English, German and Spanish.Alexander von Humboldt's work displays traces of Johann Gottfried Herder which are as multifaceted as the references to the latter are scarce. In light of this aspect, the present essay focuses on Humboldt's Physiognomy of Plants (1806, in which he explicitly mentions Herder for the first time in a publication. Two years later, the text is incorporated within Aspects of Nature (1808 ff.. In the third edition of Aspects (1849, Herder's name is curiously omitted. This omission is incomprehensible both in form and content. The historical context characterising the years between 1805 and 1808 suggests that Humboldt's references to Herder must have been made very deliberately. Humboldt's correspondence with the historian Johannes von M¸ller and other sources shows that Humboldt carefully studied Herder's writings. As the publisher of Herder's complete works, Johannes von M¸ller, who was Humboldtís friend and neighbour at the time, even considered Humboldt to be a direct descendant of the Herder school.

  15. The Serial Process in Visual Search

    Science.gov (United States)

    Gilden, David L.; Thornton, Thomas L.; Marusich, Laura R.

    2010-01-01

    The conditions for serial search are described. A multiple target search methodology (Thornton & Gilden, 2007) is used to home in on the simplest target/distractor contrast that effectively mandates a serial scheduling of attentional resources. It is found that serial search is required when (a) targets and distractors are mirror twins, and…

  16. Serial killer: il database mondiale

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    Gaetano parente

    2016-07-01

    Full Text Available The complex and multisided study of serial killers is partly made difficult by the current level of progress that has led these deviant people to evolve in relation to the aspects of shrewdness (concerning the staging and mobility. Despite the important work of some scholars who proposed important theories, all this shows that, concerning serial murders, it is still particularly frequent not to pay attention to links among homicides committed by the same person but in different parts of the world. It is therefore crucial to develop a worldwide database that allows all police forces to access information collected on crime scenes of murders which are particularly absurd and committed without any apparent reason. It will then be up to the profiler, through ad hoc and technologically advanced tools, to collect this information on the crime scene that would be made available to all police forces thanks to the worldwide database.

  17. The fallacy of serial extractions.

    Science.gov (United States)

    Lee, K Paul

    2013-11-01

    It is suggested that lingually-positioned lower lateral incisors in young children are anatomically correct and not a symptom of crowding. Primary canines with intact periodontal attachments have an important role to play as proprioceptors to encourage growth of the alveolar arch. Extractions of primary cuspids would deprive the alveolus of important growth stimuli. Clinical evidence suggests that serial extraction is counter-productive. The early extraction of primary cuspids will invariably result in crowding of the permanent cuspids. It is a common belief that serial extraction corrects the crowding of lower incisors but the procedure is not evidence based. In reality, the problem is maintained and the 'crowding' shifts to involve the permanent cuspids. Let us not forget the most basic canon of the health profession which is 'first do no harm, and if it is not broken, do not try to fix it'.

  18. The life and death of Alexander Bogdanov, physician.

    Science.gov (United States)

    Huestis, D W

    1996-08-01

    It was early in April in 1928 when the word went out in Moscow that Alexander Bogdanov had died. He was a controversial figure, an old Bolshevik who had left that party long before the 1917 revolution and never returned. All the same, he had had Lenin's respect as a scientist (as long as he stayed out of politics). More recently, he also had the support of the new party strong man, Stalin. Bogdanov opposed the growing despotism of the "dictatorship of the proletariat", under which slogan Communist autocracy was being developed. But he was respected as a tireless propagandist for the socialist cause, an enthusiastic teacher of the proletariat, and a writer of arcane science and philosophy. Bogdanov was held in such respect that Communist bigwigs spoke glowingly at the funeral, praising his intellect, courage, and dedication to science and humanity. They did not fail to point out that he had split with his one-time friend, Lenin, and had succumbed to ideological "errors". Indeed, he had powerful enemies in the early Soviet state. Bogdanov was a physician, economist, philosopher, natural scientist, writer of utopian science fiction, poet, teacher, politician (unsuccesful), lifelong revolutionary, forerunner of what we now call cybernetics and organizational science, and founder of the world's first institution devoted entirely to the field of blood transfusion. You could call him a Renaissance man. Although he clearly fitted the category of the late-nineteenth-century Russian intellectual revolutionary, Bogdanov differed from most of them in being no dilettante. More than just a theorist, he was an active scientist and physician. As a teacher, he firmly believed that education and indoctrination could alter people's ways of thinking and behaving, and that humanity could be perfected under socialism. Like many revolutionaries, Bogdanov tried to keep ahead of the Tsar's police by using a variety of pseudonyms, among them Riadavoy, Werner, Maximov, and Bogdanov. After

  19. The sexually sadistic serial killer.

    Science.gov (United States)

    Warren, J I; Hazelwood, R R; Dietz, P E

    1996-11-01

    This article explores characteristics and crime scene behavior of 20 sexually sadistic serial murderers. The pairing of character pathology with paraphilic arousal to the control and degradation of others is examined as it manifests itself in their murders. Commonalities across murders and across murderers are highlighted, i.e., the execution of murders that are well-planned, the use of preselected locations, captivity, a variety of painful sexual acts, sexual bondage, intentional torture, and death by means of strangulation and stabbing.

  20. IRIG Serial Time Code Formats

    Science.gov (United States)

    2016-08-01

    Standard This standard consists of a family of rate-scaled serial time codes with formats containing up to four coded expressions or words. All time...time code formats is designated A, B, D, E, G, and H. Various combinations of subwords and signal forms make up a time code word. To differentiate...ARE leap years. Additional information can be found at the following USNO web sites. • http://timeanddate.com/ date /leapyear.html • http

  1. Notorious Cases of Serial Killers

    Directory of Open Access Journals (Sweden)

    Iosub Elena-Cătălina

    2014-05-01

    Full Text Available The reconstruction of a death scene provides an overall picture of the crime and will indicate the murder as an event or one of a series of events and also the criminal. But when the criminal is declared a serial killer, many questions are raised up. How could a person kill some else without a reason or why people react in such a disorganized way and become so brutal or what made them act like that and so many questions with also so many answers. This project explains the psychology of a murderer, his own way of thinking and acting by presuming that we may accurately discover what is in their minds when they kill. It is about a very complex issue regarding murder investigations, biological factors and psychological profile of a serial killer. Dealing with this problem we will at last reach to the question that could solve finally the puzzle: ―Are serial murderers distorted reflections of society's own values?

  2. Serial murder by healthcare professionals.

    Science.gov (United States)

    Yorker, Beatrice Crofts; Kizer, Kenneth W; Lampe, Paula; Forrest, A R W; Lannan, Jacquetta M; Russell, Donna A

    2008-01-01

    The prosecution of Charles Cullen, a nurse who killed at least 40 patients over a 16-year period, highlights the need to better understand the phenomenon of serial murder by healthcare professionals. The authors conducted a LexisNexis search which yielded 90 criminal prosecutions of healthcare providers that met inclusion criteria for serial murder of patients. In addition we reviewed epidemiologic studies, toxicology evidence, and court transcripts, to provide data on healthcare professionals who have been prosecuted between 1970 and 2006. Fifty-four of the 90 have been convicted; 45 for serial murder, four for attempted murder, and five pled guilty to lesser charges. Twenty-four more have been indicted and are either awaiting trial or the outcome has not been published. The other 12 prosecutions had a variety of legal outcomes. Injection was the main method used by healthcare killers followed by suffocation, poisoning, and tampering with equipment. Prosecutions were reported from 20 countries with 40% taking place in the United States. Nursing personnel comprised 86% of the healthcare providers prosecuted; physicians 12%, and 2% were allied health professionals. The number of patient deaths that resulted in a murder conviction is 317 and the number of suspicious patient deaths attributed to the 54 convicted caregivers is 2113. These numbers are disturbing and demand that systemic changes in tracking adverse patient incidents associated with presence of a specific healthcare provider be implemented. Hiring practices must shift away from preventing wrongful discharge or denial of employment lawsuits to protecting patients from employees who kill.

  3. Serial position learning in honeybees.

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    Randolf Menzel

    Full Text Available Learning of stimulus sequences is considered as a characteristic feature of episodic memory since it contains not only a particular item but also the experience of preceding and following events. In sensorimotor tasks resembling navigational performance, the serial order of objects is intimately connected with spatial order. Mammals and birds develop episodic(-like memory in serial spatio-temporal tasks, and the honeybee learns spatio-temporal order when navigating between the nest and a food source. Here I examine the structure of the bees' memory for a combined spatio-temporal task. I ask whether discrimination and generalization are based solely on simple forms of stimulus-reward learning or whether they require sequential configurations. Animals were trained to fly either left or right in a continuous T-maze. The correct choice was signaled by the sequence of colors (blue, yellow at four positions in the access arm. If only one of the possible 4 signals is shown (either blue or yellow, the rank order of position salience is 1, 2 and 3 (numbered from T-junction. No learning is found if the signal appears at position 4. If two signals are shown, differences at positions 1 and 2 are learned best, those at position 3 at a low level, and those at position 4 not at all. If three or more signals are shown these results are corroborated. This salience rank order again appeared in transfer tests, but additional configural phenomena emerged. Most of the results can be explained with a simple model based on the assumption that the four positions are equipped with different salience scores and that these add up independently. However, deviations from the model are interpreted by assuming stimulus configuration of sequential patterns. It is concluded that, under the conditions chosen, bees rely most strongly on memories developed during simple forms of associative reward learning, but memories of configural serial patterns contribute, too.

  4. 非手术序列化治疗单侧梅尼埃病48例%Non-surgical serialization treatment of unilateral Meniere disease in 48 cases

    Institute of Scientific and Technical Information of China (English)

    张运波; 习国平; 靳红芳; 王彩君

    2016-01-01

    Objective To explore the efficacy of treating Meniere disease by non-operative serialization through various listening stages.Methods Serialized treatment was conducted in 48 patients with unilateral Meniere disease according to the listening stages.In period Ⅰ,patients received regular diet control,blood vessel expansion,nerve nutrition and vitamin medication.In period Ⅱ,on the basis of conventional treatment,patients were injected with odium succinate 40 mg,once in 3 days for 3 times.If it was not effective,tympanostomy tube and tympanic cavity inflation were ad-ministered.In period Ⅲ,on the basis of regular treatment,patients underwent tympanic cavity perfusion after tympa-nostomy tube and injection of prednisolone sodium of 40 mg,once in 3 days for 3 times,and received inflation treat-ment in middle ear drum balloon.In period Ⅳ,on the basis of conventional treatment,patients received gentamicin 40 000 U +0.5%,sodium bicarbonate 0.5 mL and tympanic cavity injection once a week.The frequency of injection was commonly 2-3 times a week,determined by circumgyration,hearing changes and situations of tinnitus.For patients who had low vestibular apparatus function,rehabilitation training of vestibular function was provided.Patients’vertigo, hearing,activity ability and tinnitus changes were followed up for 18-24 months.Results Vertigo was fully controlled in 12 cases,basically controlled in 33 cases,partially controlled in 3 cases,and the clinical effective rate was 93%. The hearing ability was improved to A level in 12 cases (>30 db or the frequency <20 db),to B level in 6 cases (15-30 db),to C level in 29 cases (0-14 db),and to Dlevel in 1 case (improvement <0 db).The mobility was fully con-trolled in 16 cases (A level),basically controlled in 32 cases (B level),and the effective rate was 100%.The score of Tinnitus Handicap Inventory after treatment was significantly decreased (P <0.05 ).Conclusion Treatment of Meniere disease vertigo by non

  5. IN MEMORIAM: In Memoriam: Alexander A Golovin and Alexei M Oparin In Memoriam: Alexander A Golovin and Alexei M Oparin

    Science.gov (United States)

    2008-10-01

    In Memoriam of Alexander A Golovin (1962-2008) Alexander (Sasha) Golovin passed away on 10 September 2008. Sasha's scientific heritage includes seminal works in different fields of physics, from Marangoni convection to self-assembly of quantum dots, and from combustion fronts to anomalous diffusion in flows and on a crystal surface. A graduate of the Moscow Institute for Physics and Technology, he had very broad scientific interests and a unique ability to identify and solve new, intellectually challenging and technologically important problems. One of the basic fields of Sasha's research was the fluid dynamics in systems with interfaces. His favorite subject was the motion of droplets, bubbles and particles in the presence of heat and mass transfer. Sasha's early works contained the discovery of the spontaneous motion of droplets due to the Marangoni effect and the investigation of the interaction between solid particles, bubbles and droplets caused by the Marangoni effect, which is a crucial factor that determines the effect of heat/mass transfer on the rate of coalescence. In both cases, Sasha's work was the first in a long sequence of papers written by different authors. Later, Sasha returned to that field when studying such fascinating subjects as levitation of droplets above the surface of an evaporating liquid and encapsulation of particles and bubbles by an advancing solidification front. The subject of interfacial hydrodynamics overlaps with another basic field of Sasha's research, the theory of pattern formation. The contribution of Sasha's work to the modern understanding of the variety of pattern formation phenomena is significant. It includes the analysis of the interaction between long-wave and short-wave instability modes in Marangoni convection, investigation of the large-scale Marangoni convection that led to the prediction of different patterns including quasipatterns, and the description of various non-potential effects in Marangoni convection

  6. Reconciling rising serials costs, the serials budget, and reference needs in a medical library serials retrenchment program: a methodology.

    Science.gov (United States)

    Spang, L

    1995-01-01

    Devising a coherent serials retrenchment plan while maintaining quality reference service is a dilemma faced by increasing numbers of medical librarians. In 1991, the staff of the Shiffman Medical Library, Wayne State University, began to address increasing serials budget reductions that by 1994 amounted to a projected 20% maximum cut. The resulting retrenchment plan combined an ongoing serials use study, faculty and librarian reviews of cancellation lists, and systematic refinements in interlibrary cooperation and document delivery service. The Shiffman plan provides a constructive framework that can be adapted to other medical libraries facing immediate, major serials retrenchment.

  7. The Relationship Context of Premarital Serial Cohabitation.

    Science.gov (United States)

    Cohen, Jessica; Manning, Wendy

    2010-09-01

    Even though serial cohabitation is on the rise, it has not been integrated into recent family research. We analyze the National Survey of Family Growth (NSFG) cycle 6 to explore the relationship context of serial cohabitation for women throughout emerging adulthood (N=3,397). We provide a relationship context for serial cohabitation by examining the age at first cohabitation, duration of cohabiting unions, marital expectations and transitions, as well as premarital sexual histories. Furthermore, we examine the change in these relationship indicators across women's birth cohorts. We find that serial cohabitors' co-residential unions are about the same duration as single-instance cohabiting unions. Serial cohabitors start cohabiting younger, report lower marital expectations than single-instance cohabitors and a smaller proportion marry before age 30. Women who have more premarital sex partners have significantly greater odds of serial cohabiting. These findings indicate that women face increasingly complex relationship trajectories during emerging adulthood.

  8. Tartu ülikooli Vene ajaloo professor Alexander Brückner (1834-1896) / Tiit Rosenberg

    Index Scriptorium Estoniae

    Rosenberg, Tiit, 1946-

    2004-01-01

    Alexander Brückneri elust, vaadetest, loomingust ja perekonnast. Alexander Brücknerist kui Õpetatud Eesti Seltsi liikmest. Tartu Ülikooli vene ajaloo õppejõududest. Lühidalt Tartust pärit vene ajaloo uurijast Ernst Adolf Herrmannist

  9. Serial turbo trellis coded modulation using a serially concatenated coder

    Science.gov (United States)

    Divsalar, Dariush (Inventor); Dolinar, Samuel J. (Inventor); Pollara, Fabrizio (Inventor)

    2011-01-01

    Serial concatenated trellis coded modulation (SCTCM) includes an outer coder, an interleaver, a recursive inner coder and a mapping element. The outer coder receives data to be coded and produces outer coded data. The interleaver permutes the outer coded data to produce interleaved data. The recursive inner coder codes the interleaved data to produce inner coded data. The mapping element maps the inner coded data to a symbol. The recursive inner coder has a structure which facilitates iterative decoding of the symbols at a decoder system. The recursive inner coder and the mapping element are selected to maximize the effective free Euclidean distance of a trellis coded modulator formed from the recursive inner coder and the mapping element. The decoder system includes a demodulation unit, an inner SISO (soft-input soft-output) decoder, a deinterleaver, an outer SISO decoder, and an interleaver.

  10. Planar Serial Manipulator Motion Synthesis

    Institute of Scientific and Technical Information of China (English)

    Yanhui Wei; Han Han; Zepeng Wang; Xin Liu; Guangchun Li

    2015-01-01

    This paper deals with the universal serial manipulator on the inverse kinematics problem of plane type, the fast working space solution method, and the obstacle avoidance path planning method. With the vector projection as the main constraint condition of the target, it proposes a general form of the inverse kinematics solution which does not depend on the robot configuration of freedom degree. By identifying the target vector direction maximum and minimum workspace boundary and determining the destination vector by thick search on the workspace boundary method, an expressing method of the polar coordinate form of work space is then introduced. Finally, according to the form of plane trajectory planning for obstacle avoidance problem, the method of solving the inverse kinematics solution of the concave and convex forms of the safe obstacle avoidance area is improved. The simulation results verify that the proposed method has feasibility and generality.

  11. Alexander Cameron Rutherford: A Gentleman and a Scholar. Documents in the Classroom.

    Science.gov (United States)

    Hodysh, Henry W.

    2000-01-01

    Provides information about Alexander Cameron Rutherford, a provincial politician. Includes a letter written by Rutherford in 1912 that provides insights into his responsibilities to the general public, information about Rutherford himself, the economic conditions of Alberta, Canada in 1912, and information about the individual to whom it was…

  12. A Disciplinary Immigrant. Alexander Smith at the University of Chicago, 1894-1911

    Science.gov (United States)

    Cotter, Donald

    2008-01-01

    The publication in 1906 of Alexander Smith's "Introduction to general inorganic chemistry" inaugurated a decisive change in chemical pedagogy in the US, the effects of which are still evident. The nature and extent of Smith's innovations are described through a comparison of his text to its source material and contemporaries. His…

  13. Synoptisches Erzählen - Darstellungen des Bombenkriegs bei Gert Ledig, Alexander Kluge und Dieter Forte

    DEFF Research Database (Denmark)

    Hoffmann, Birthe

    2009-01-01

    Artiklen foretager en sammenlignende analyse af Gert Ledigs roman "Vergeltung" (1956), Alexander Kluges hybride tekst "Der Luftangriff auf Halberstadt am 8. April 1945" (1976) og Dieter Fortes roman "Der Junge mit den Blutigen Schuhen" (1995) med henblik på en diskussion af fortællemæssige...

  14. Alexander Pechersky Testifies: an Open Page of Sobibor Death Camp History

    Directory of Open Access Journals (Sweden)

    Lev S. Simkin

    2013-01-01

    Full Text Available Here, the author introduces the interrogation of the witness Alexander Aronovich Pechersky, the leader of the German death camp Sobibor Revolt during the World War II. Special attention is attached to the daily life of the death camp. The picture of revolt preparation was completed

  15. Stubb : EL saavutas Gruusia kriisi ajal palju / Alexander Stubb ; interv. Liisi Poll

    Index Scriptorium Estoniae

    Stubb, Alexander, 1968-

    2008-01-01

    Intervjuu Soome välisministri Alexander Stubbiga, kes vastab küsimustele, mis puudutavad Euroopa Liidu positsiooni seoses Venemaa agressiooniga Gruusias ja Soome seisukohti seoses NATOga. Euroliidu reaktsioon Venemaa agressioonile Gruusias oli poliitiliselt tugev ja majanduslikult nõrk, arvab ta

  16. The Serial Murderer's Motivations: An Interdisciplinary Review.

    Science.gov (United States)

    DeHart, Dana D.; Mahoney, John M.

    1994-01-01

    Defines serial killer as individual who murders two or more victims over an extended period of time, ranging from days to years, with the crimes often being sexually motivated. Reviews existing motivational theories of serial murder and proposes additional explications from range of disciplines. Presents suggestions for future research and…

  17. The Use of OCLC for Serials Control.

    Science.gov (United States)

    Seidner, Cathy

    Designed for use by serials librarians concerned with the implementation of OCLC (Ohio College Library Center) in their individual libraries, librarians responsible for deciding to adopt OCLC rather than a competitive system or to add the Serials Subsystem to the services they already receive from OCLC, and information scientists and systems…

  18. Serial Position Functions in General Knowledge

    Science.gov (United States)

    Kelley, Matthew R.; Neath, Ian; Surprenant, Aimée M.

    2015-01-01

    Serial position functions with marked primacy and recency effects are ubiquitous in episodic memory tasks. The demonstrations reported here explored whether bow-shaped serial position functions would be observed when people ordered exemplars from various categories along a specified dimension. The categories and dimensions were: actors and age;…

  19. [Guided tooth eruption via serial extraction].

    Science.gov (United States)

    Luyten, C

    1995-01-01

    Crowding of teeth is the result of arch length discrepancy (ALD). Minimal crowding can be solved with slice-technique, more severe crowding (ALD > or = 5 mm) can be intercepted with a serial extraction procedure. In this paper a sequence of serial extraction will be explained and illustrated with case reports.

  20. Modus operandi of female serial killers.

    Science.gov (United States)

    Wilson, W; Hilton, T

    1998-04-01

    The modus operandi of female serial killers was examined from a chronology of 58 cases in America and 47 cases in 17 other countries, compiled over 25-year intervals. Female serial killers in other countries accounted for a disproportionately greater number of victims, but those in America managed a longer killing career when associated with a low profile modus operandi.

  1. Obituary: Alexander (Andy) Franz Lubenow, 1956-2005

    Science.gov (United States)

    Buie, Marc William

    2006-12-01

    Alexander (Andy) Franz Lubenow, Program Coordinator at the Space Telescope Science Institute, was diagnosed with cancer of the gallbladder, pancreas, and liver in May 2005 and died on 29 September 2005. He was forty-nine. Andy was born to Bodo and Helen Lubenow in St. Paul, Minnesota on 4 January 1956. In 1964 at the age of eight, he moved with his family to Buenos Aires, Argentina, and attended the American Community School there until returning with his family in 1973 to St. Paul. Argentina had a big impact on Andy's future as an astronomer. He later recalled how he had observed and was puzzled by the "upside-down" appearance of the Moon in the southern hemisphere. In Argentina, he built his first telescope using a mirror he had ground himself. He never parted ways with that instrument. Andy did not follow a standard educational track. He spent two years at St. Olaf College in Northfield, Minnesota, before transferring to the University of Minnesota, where he earned his bachelor's degree and began work towards a master's degree in astrophysics. Later he transferred to the University of Illinois at Urbana-Champaign, where he remained until Dr. Peter Stockman hired him to work on the Hubble Space Telescope project. While in school, he worked as a teacher's assistant, taught night school, and gave demonstrations of stargazing. He was an excellent teacher and had a flair for writing. He later wrote articles for a sailing magazine and a pilot's magazine. Andy was a very practical, meticulous, and steady worker, attributes that he combined with an understated and dry sense of humor. He was always able to find a way through a problem, no matter how sticky. If a job required him to roll up his sleeves and get it done through hard work, he would persevere. Nevertheless, he was always on the lookout for an easier way. He had no patience for being forced to deal with stupid things for stupid reasons. At work at the Space Telescope Science Institute (STScI), Andy was

  2. Oscillator-based memory for serial order.

    Science.gov (United States)

    Brown, G D; Preece, T; Hulme, C

    2000-01-01

    A computational model of human memory for serial order is described (OSCillator-based Associative Recall [OSCAR]). In the model, successive list items become associated to successive states of a dynamic learning-context signal. Retrieval involves reinstatement of the learning context, successive states of which cue successive recalls. The model provides an integrated account of both item memory and order memory and allows the hierarchical representation of temporal order information. The model accounts for a wide range of serial order memory data, including differential item and order memory, transposition gradients, item similarity effects, the effects of item lag and separation in judgments of relative and absolute recency, probed serial recall data, distinctiveness effects, grouping effects at various temporal resolutions, longer term memory for serial order, list length effects, and the effects of vocabulary size on serial recall.

  3. Serial killers with military experience: applying learning theory to serial murder.

    Science.gov (United States)

    Castle, Tammy; Hensley, Christopher

    2002-08-01

    Scholars have endeavored to study the motivation and causality behind serial murder by researching biological, psychological, and sociological variables. Some of these studies have provided support for the relationship between these variables and serial murder. However, the study of serial murder continues to be an exploratory rather than explanatory research topic. This article examines the possible link between serial killers and military service. Citing previous research using social learning theory for the study of murder, this article explores how potential serial killers learn to reinforce violence, aggression, and murder in military boot camps. As with other variables considered in serial killer research, military experience alone cannot account for all cases of serial murder. Future research should continue to examine this possible link.

  4. Clinical application of serial operations with preserving spleen

    Institute of Scientific and Technical Information of China (English)

    Hong-Chi Jiang; Bei Sun; Hai-Quan Qiao; Jun Xu; Da-Xun Piao; Hang Yin

    2001-01-01

    AIM: To evaluate the clinical application of serial operations with preservation of spleen. METHODS: Serial operations with preserving spleen were performed on 211 cases in our hospital from 1980 to 2000.The patient's age ranged from 13 to 56 years, averaging 3years. Diseases included splenic injury in 171 cases, portal hypertension in 9 cases, splenic cyst in 10 cases, and the lesion of pancreatic body and tail in 21 cases. RESULTS: All the cases were cured, and 129 patients were followedup from 3 months to 3 years with the leukocyte phagocytosis test, detection of immunoglubin, CT, 99mTc scanning and ultrasonogrsphy. The results were satisfactory. CONCLUSION: The operations with preserving spleen were safe, feasible, and worth of clinical application.

  5. Background instrumental music and serial recall.

    Science.gov (United States)

    Nittono, H

    1997-06-01

    Although speech and vocal music are consistently shown to impair serial recall for visually presented items, instrumental music does not always produce a significant disruption. This study investigated the features of instrumental music that would modulate the disruption in serial recall. 24 students were presented sequences of nine digits and required to recall the digits in order of presentation. Instrumental music as played either forward or backward during the task. Forward music caused significantly more disruption than did silence, whereas the reversed music did not. Some higher-order factor may be at work in the effect of background music on serial recall.

  6. [Urology and National Socialism: the fate of Alexander von Lichtenberg 1880-1949].

    Science.gov (United States)

    Moll, F H; Krischel, M; Rathert, P; Fangerau, H

    2010-09-01

    Alexander von Lichtenberg (1880-1949) was one of the famous members of the German Urological Society (DGU) in pre-war Germany. He introduced excretion urography and a special TURP Instrument. In 1928 he was president of the 8th meeting held in the German capital Berlin. His Handbook of Urology, released by Ferdinand Springer publishing house, was a trendsetter in establishing urology as a specialty in Germany and bringing together the whole wisdom of all aspects of urology. He was the founder of the famous Maximilian Nitze Award of the DGU. As a Jew he-like many others-was forced to leave Nazi Germany after 1933. Even in Hungary, his native country, he again had to resist anti-Semitic hostility. Later on he lived in Mexico. Alexander von Lichtenberg has to be remembered with special focus on the exodus of German Jewish scientists during the Nazi time.

  7. Berglinien im Vergleich. Bemerkungen zu einem klimageografischen Diagramm Alexander von Humboldts

    OpenAIRE

    2013-01-01

    Zusammenfassung Der Artikel analysiert aus bildwissenschaftlicher und historischer Perspektive die unveröffentlichte Skizze zu einem Bergdiagramm aus dem handschriftlichen Nachlass Alexander von Humboldts. Das mehrfach beklebte Skizzenblatt stand im Zentrum klimageografischer Fragestellungen nach den Gründen für die weltweit unterschiedlich hohen Schneegrenzen in Gebirgen. Aufgrund des unfertigen, skizzenhaften Charakters des Diagramms lassen sich Fragen über den Forschungskontext des Dia...

  8. Reflection in Russian public opinion accession to the throne of Emperor Alexander II

    Directory of Open Access Journals (Sweden)

    Maxim N. Krot

    2016-03-01

    Full Text Available The article deals with the perception of Russian society coming to the throne of Emperor Alexander II in 1855. The author analyzes the internal and external situation in Russia in this period, identifying the most significant factors that influenced the public's attitude to the new monarch, and the expectations that were associated with his coming to power. The article draws parallels between the initial period of the reign of the two liberal Russian monarchs of the XIX century – Alexander I and Alexander II, most clearly expressed not so much in the circumstances of their accession, but in the public mood that prevailed in the country. It presents a broad picture of the "awakening" of public consciousness and activity after the stagnation and oppression of the preceding reign, which was reflected primarily in an effort to think freely and to discuss pressing issues facing the country, as well as contribute to the supreme power in the modernization of social and political relations, awareness where necessary, at this time it becomes clearly. The author identifies semantic levels of social consciousness of the period, indicating the particular circumstances that have shaped them. Much attention is paid to the influence of Russian society of the Crimean War, which in many ways was the starting point of social upheaval transformed in 1855 from a national-patriotic in the socio-political. The author points out that at this time has unique conditions for overcoming the contradictions between state and society and their successful cooperation in the reform of the country. This suggests a significant, perhaps - the crucial role of the public in the selection of the vector conversion of Russia, which has become a feature of the reign of Alexander II.

  9. Randomised controlled trial of Alexander technique lessons, exercise, and massage (ATEAM) for chronic and recurrent back pain

    OpenAIRE

    Little, Paul; Lewith, George; Webley, Fran; Evans, Maggie; Beattie, Angela; Middleton, Karen; Barnett, Jane; Ballard, Kathleen; Oxford, Frances; Smith, Peter; Yardley, Lucy; Hollinghurst, Sandra; Sharp, Debbie

    2008-01-01

    Objective To determine the effectiveness of lessons in the Alexander technique, massage therapy, and advice from a doctor to take exercise (exercise prescription) along with nurse delivered behavioural counselling for patients with chronic or recurrent back pain. Design Factorial randomised trial. Setting 64 general practices in England. Participants 579 patients with chronic or recurrent low back pain; 144 were randomised to normal care, 147 to massage, 144 to six Alexander technique lessons...

  10. History and Pre-History of the Alexander von Humboldt Foundation

    Directory of Open Access Journals (Sweden)

    D. Platikanov

    2014-02-01

    Full Text Available In this paper a short review of the history of Alexander von Humboldt Foundation, Bonn - Bad Godesberg, Germany, on the occasion of its 60th anniversary is presented. This outstanding German foundation is actually the third one with the same name. Earlier two other Alexander von Humboldt Foundations consequently existed and they consist its pre-history, which is also shortly reviewed. The establishment of the present Foundation in 1953, its development and growth, its activities, information about the six presidents and five executive directors, as well as the main features, principles and guidelines are considered. During the last 60 years the Alexander von Humboldt Foundation became an important institution for the promotion of international research cooperation, which significantly influences the world science. It supported more than 27700 Humboldt fellows to carry out scientific research in Germany, and they form a large Humboldt family: a world-wide network. Large number Bulgarian Humboldt fellows are among the best scientists in Bulgaria.

  11. A Novel Methodology for Designing Radix-2n Serial-Serial Multipliers

    Directory of Open Access Journals (Sweden)

    Abdurazzag S. Almiladi

    2010-01-01

    Full Text Available Problem statement: The fast growth and increase in complexity of digital and image processing systems necessitate the migration from ad hoc design methods to methodological ones. Methodologies will certainly ease the trade off selection for those systems and shortens the design time. To increase those gained values and expand the searching space more appropriate methodologies need to be developed. Approach: A new methodology (table methodology to design radix-2n serial-serial multipliers was presented. Unlike other methodologies, the table methodology was used for the full design cycle, from the algorithm to the detailed fine control. Results: The methodology was used to identify the drawbacks in existing radix-2n serial-serial multipliers as well as deriving new efficient ones. Conclusion/Recommendations: To the author's knowledge this is the first time tables are used in this novel way in tackling the complete solution space of serial-serial multipliers. One important merit of the new methodology is that it made it clear that there is no need of parallel loading in serial-parallel architectures and hence they can be transferred to serial-serial ones and a as a consequence a huge saving of bus width, I/O pins, area and energy will be achieved.

  12. Plutarcho Aleksandras: interpretacijos problemos. Plutarch‘s Alexander: Problems of Interpretation

    Directory of Open Access Journals (Sweden)

    Nijolė Juchnevičienė

    2010-01-01

    Full Text Available Alexander‘ s character and his activities occupy a special position in the works of Plutarch. Alexander’s Life is the second largest life in the corpus, there are two elaborated speeches on him included into Moralia, and he is often mentioned in the other pieces of this corpus. The speeches, usually called De Alexandri Magni fortuna aut virtute (A and B, were written by the young Plutarch. They belong to the epideictic rhetoric tradition and are based on the opposition between the hero’s ἀρετήand τύχη, which was in general not favor­able to him. According to Plutarch, all Alexander’s life was a struggle between τύχη and ἀρ��τή. The speeches reveal the impressive portrait of Alexander not only as an invincible warrior, but also as a philosopher in arms, whose immortal achievements are the best proof of his ἀρετή. He managed to overcome the unfavorable τύχη and to civilize the world of the barbarians. There is a difference of interpretation of the character between the speeches and the Life. Alexander is not as perfect there as in the speeches, but his character still is in the center of the narration. The motive of ἀρετήvs. τύχη is also present and Plutarch still sticks to his earlier opinion that Alexander’s ἀρετή, not τύχη was the decisive factor in his life. Plutarch notices the changes in Alexander and his negative features, but at the same time, he tries to explain and extenuate his behavior pointing out to Alexander’s extreme valuation of his δόξα, which he regarded more important than the royal power and the life itself. In my opinion, Alexander’s attitude to his δόξα reveals the difference between the heroes of the pair, Alexander and Caesar. This differ­ence is also expanded in the detailed description of the post-mortal status and fate of their bodies, the effect that reminiscence of them makes on the living. I agree with the opinion, that Caesar is

  13. Teachers' professional development needs and current practices at the Alexander Science Center School

    Science.gov (United States)

    Gargus, Gerald Vincent

    This investigation represents an in-depth understanding of teacher professional development at the Alexander Science Center School, a dependent charter museum school established through a partnership between the California Science Center and Los Angeles Unified School District. Three methods of data collection were used. A survey was distributed and collected from the school's teachers, resulting in a prioritized list of teacher professional development needs, as well as a summary of teachers' opinions about the school's existing professional development program. In addition, six key stakeholders in the school's professional development program were interviewed for the study. Finally, documents related to the school's professional development program were analyzed. Data collected from the interviews and documents were used to develop an understand various components of the Alexander Science Center School's professional development program. Teachers identified seven areas that had a high-priority for future professional development including developing skills far working with below-grade-level students, improving the analytical skills of student in mathematics, working with English Language Learners, improving students' overall reading ability levels, developing teachers' content-area knowledge for science, integrating science across the curriculum, and incorporating hands-on activity-based learning strategies to teach science. Professional development needs identified by Alexander Science Center School teachers were categorized based on their focus on content knowledge, pedagogical content knowledge, or curricular knowledge. Analysis of data collected through interviews and documents revealed that the Alexander Science Center School's professional development program consisted of six venues for providing professional development for teachers including weekly "banked time" sessions taking place within the standard school day, grade-level meetings, teacher support

  14. [The serial murder: a few theoretical perspectives].

    Science.gov (United States)

    Leistedt, S; Linkowski, P

    2011-01-01

    Despite numbers of publications and effort to try to establish the definition, the classification, the epidemiology, the clinical aspects and the psychopathology of serial killers, a universal consensus seems to say the least. Crime, though reduced in some countries, appears to impact more and more consistent worldwide, generating controversial ideas and a multitude of possible explanations. The serial killer usually presents as a caucasian man, aged between 20 and 40 years, often embedded socially and in his family, but with serious psychiatric, personal and especially family history. Usually acting alone, the serial killer plans a crime well in advance, but sometimes within the scope of impulsivity for a minority, the victim not being previously selected. In the latter case, an actual mental illness like psychosis is found. It is clear from numerous psychopathological studies conducted so far that most serial killers are defined as psychopathic sexual sadists, whose childhood was difficult, if not flouted, punctuated by physical and psychological violence situations. In addition, pervasive fantasies combined with thoughts of death, sex and violence are as much in common with the original acts of which they are the instigators. Beyond a relentless media that is constantly watering the public with stories and pictures depicting them as such, serial killers remain an enigma. We can therefore attempt to answer the various questions raised by this phenomenon, the way these people operate and how we can curb the rise, thanks to the neurobiological and neurophysiological approaches that science offers us.

  15. Stochastic modeling of a serial killer.

    Science.gov (United States)

    Simkin, M V; Roychowdhury, V P

    2014-08-21

    We analyze the time pattern of the activity of a serial killer, who during 12 years had murdered 53 people. The plot of the cumulative number of murders as a function of time is of "Devil's staircase" type. The distribution of the intervals between murders (step length) follows a power law with the exponent of 1.4. We propose a model according to which the serial killer commits murders when neuronal excitation in his brain exceeds certain threshold. We model this neural activity as a branching process, which in turn is approximated by a random walk. As the distribution of the random walk return times is a power law with the exponent 1.5, the distribution of the inter-murder intervals is thus explained. We illustrate analytical results by numerical simulation. Time pattern activity data from two other serial killers further substantiate our analysis.

  16. Serial concept maps: tools for concept analysis.

    Science.gov (United States)

    All, Anita C; Huycke, LaRae I

    2007-05-01

    Nursing theory challenges students to think abstractly and is often a difficult introduction to graduate study. Traditionally, concept analysis is useful in facilitating this abstract thinking. Concept maps are a way to visualize an individual's knowledge about a specific topic. Serial concept maps express the sequential evolution of a student's perceptions of a selected concept. Maps reveal individual differences in learning and perceptions, as well as progress in understanding the concept. Relationships are assessed and suggestions are made during serial mapping, which actively engages the students and faculty in dialogue that leads to increased understanding of the link between nursing theory and practice. Serial concept mapping lends itself well to both online and traditional classroom environments.

  17. The eyeball killer: serial killings with postmortem globe enucleation.

    Science.gov (United States)

    Coyle, Julie; Ross, Karen F; Barnard, Jeffrey J; Peacock, Elizabeth; Linch, Charles A; Prahlow, Joseph A

    2015-05-01

    Although serial killings are relatively rare, they can be the cause of a great deal of anxiety while the killer remains at-large. Despite the fact that the motivations for serial killings are typically quite complex, the psychological analysis of a serial killer can provide valuable insight into how and why certain individuals become serial killers. Such knowledge may be instrumental in preventing future serial killings or in solving ongoing cases. In certain serial killings, the various incidents have a variety of similar features. Identification of similarities between separate homicidal incidents is necessary to recognize that a serial killer may be actively killing. In this report, the authors present a group of serial killings involving three prostitutes who were shot to death over a 3-month period. Scene and autopsy findings, including the unusual finding of postmortem enucleation of the eyes, led investigators to recognize the serial nature of the homicides.

  18. Das Ganze der Natur Alexander von Humboldt und das romantische Forschungsprogramm

    Directory of Open Access Journals (Sweden)

    Kristian Köchy

    2002-10-01

    Full Text Available Article in German, Abstracts in English, German and Spanish. The wholeness of natureAlexander von Humboldt and the romantic research programIt does not seem to be clear whether there is a tight junction between the humboldian science and the romantic research program. But by recognizing the principal aim of Humboldts concept – the representation of nature as a whole – one can see how Humboldts view has been developed in contact with romantic ideas. This investigation analyses Humboldts research program in consideration of its main features and the special relations between science, philosophy of nature, feeling of nature, history and art.

  19. CULTURES OF ANARCHY: ALEXANDER WENDT, CONSTRUCTIVISM AND THE END OF THE COLD WAR

    OpenAIRE

    DAVID NICOLAU VIGNA LEHMANN

    2003-01-01

    A tese aborda a teoria construtivista de Alexander Wendt e o debate teórico em torno da guerra fria, particularmente de seu final, enfatizando o caráter social do sistema internacional, e as diversas formas que esta estrutura de conhecimento compartilhado pode assumir: as culturas da anarquia. Analisando o Novo Pensamento como uma ação crítica, reflexiva, e utilizando as ferramentas do interacionismo simbólico, a teoria idealista e estrutural de Wendt abr...

  20. Alexander Fleming, citrated blood and penicillin: paths not pursued and applications delayed.

    Science.gov (United States)

    Mortimer, P P

    2009-12-01

    Ninety years ago Alexander Fleming (later to discover penicillin) jointly wrote a description of the use of indirect transfusions of citrated blood at a World War 1 (WW1) base hospital. It was the longest series yet to be published, incorporating what was then a novel procedure for treating war casualties. Returning to civilian life Fleming, a qualified surgeon and bacteriologist, chose a different career path, and not until the wars of the late 1930s were the advances in transfusion in WW1 fully incorporated into the management of trauma and haemorrhage. Like penicillin, the benefits of indirect transfusion were only slowly realised.

  1. The presentation of the results of Alexander von Humboldt's voyage to Carlos IV

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Puig-Samper

    2016-05-01

    Full Text Available Resumen  Desde nuestras primeras investigaciones sobre la estancia de Alexander von Humboldt en España siempre nos sorprendió la ausencia de una mínima relación posterior del sabio prusiano con la corona española y sus autoridades. Iniciada una nueva investigación, encontramos que efectivamente se produjo el envío de un primer trabajo a Carlos IV desde Roma acompañado de una carta de gratitud por la protección recibida durante su viaje americano y de sumisión a la corona española, que ahora presentamos.   Summary Ever since our first research into Alexander von Humboldt's stay in Spain, the absence of an ensuing relationship between the wise Prussian and the Spanish Crown and Authorities had always surprised us. On starting new research, we found that indeed he sent his first work to Carlos IV from Rome accompanied by a letter of gratitude for the protection he had received during his American trip and submission to the Spanish Crown, which we now present. This first literary fruit of his voyage, which Alexander von Humboldt alluded to in the letter is the first instalment of his work Plantes Équinoxiales, Recueillies au Mexique, dans l’ile de Cuba, dans les provinces de Caracas, de Cumana etc., published in Paris in 1805.   Zusammenfassung Seit unseren ersten Forschungen über den Aufenthalt Alexander von Humboldts in Spanien hat uns das Fehlen einer hieran anschließenden Beziehung des preußischen Wissenschaftlers mit der spanischen Krone und ihren Behörden erstaunt. Im Laufe einer erneuten Aufnahme der Forschung, haben wir nun entdeckt, dass Humboldt in der Tat von Rom aus eine erste Arbeit an Karl IV gesandt hatte, zusammen mit einem Schreiben des Dankes (für den während der amerikanischen Reise erhaltenen Schutz sowie seiner Unterordnung unter die spanische Krone, das wir nun präsentieren. Das erste literarische Ergebnis seiner Reise, auf das Humboldt in diesem Brief verweist, ist der erste Faszikel seines Werkes

  2. Rar o koshmare ili intervju, kotorogo ne bõlo / Alexander Rahr ; interv. Jana Toom

    Index Scriptorium Estoniae

    Rahr, Alexander

    2008-01-01

    Tallinnas toimus 2007. a. aprillisündmustele pühendatud V Kodurahu foorum. Esinejate hulgas oli ka tuntud Saksa politoloog Alexander Rahr, kes Eestisse saabus loenguga teemal "Saksamaa-Venemaa: strateegilise partnerluse ülesehitamise kogemused". Lääneriigid on veendunud, et NATO ja Euroopa Liidu laienemine tugevdab ja konsolideerib demokraatlikku Euroopat, kuid Venemaad uude Euroopasse mitteintegreerides teeb Lääs strateegilise vea, mille eest tasumine jääb järgnevatele põlvedele. Kahjuks aitab eneseisolatsioonile kaasa ka Moskva tegevus. Euroopa ühise kodu idee, vanade ja uute Euroopa Liidu liikmete suhted Venemaaga, teemad, mis vajaksid kogu Euroopa koostööd

  3. Iranian Serials Published in Latin Languages.

    Science.gov (United States)

    Harvey, John F.

    A list of English, French and German serials published in Iran and available for subscription abroad is given. Bibliographic information is included for each publication. The list was compiled with the help of Guity Afshar and Anoush Hovsepian from Pouri Soltani's "Directory of Iranian Periodicals," 1971. It was distrubuted to certain…

  4. Recalling visual serial order for verbal sequences

    NARCIS (Netherlands)

    Logie, R.H.; Saito, S.; Morita, A.; Varma, S.; Norris, D.

    2016-01-01

    We report three experiments in which participants performed written serial recall of visually presented verbal sequences with items varying in visual similarity. In Experiments 1 and 2 native speakers of Japanese recalled visually presented Japanese Kanji characters. In Experiment 3, native speakers

  5. Advances in Serials Management. Volume 6.

    Science.gov (United States)

    Hepfer, Cindy, Ed.; Gammon, Julia, Ed.; Malinowski, Teresa, Ed.

    In order to further discussion and support constructive change, this volume presents the following eight papers on various dimensions of serials management: (1) "CD-ROMs, Surveys, and Sales: The OSA [Optical Society of America] Experience" (Frank E. Harris and Alan Tourtlotte); (2) "Management and Integration of Electronic Journals into the…

  6. Memory operations in rapid serial visual presentation

    NARCIS (Netherlands)

    Akyürek, Elkan G.; Hommel, Bernhard

    2006-01-01

    Short-term memory (STM) has often been considered to be a central resource in cognition. This study addresses its role in rapid serial visual presentation (RSVP) tasks tapping into temporal attention-the attentional blink (AB). Various STM operations are tested for their impact on performance and, i

  7. Dutch Cross Serial Dependencies in HPSG

    CERN Document Server

    Rentier, G

    1994-01-01

    We present an analysis of Dutch cross serial dependencies in Head-driven Phrase Structure Grammar. Arguably, our analysis differs from other analyses in that we do not refer to `additional' mechanisms (e.g., sequence union, head wrapping): just standard structure sharing, an immediate dominance schema and a linear precedence rule.

  8. Coordination in serial-parallel image processing

    Science.gov (United States)

    Wójcik, Waldemar; Dubovoi, Vladymyr M.; Duda, Marina E.; Romaniuk, Ryszard S.; Yesmakhanova, Laura; Kozbakova, Ainur

    2015-12-01

    Serial-parallel systems used to convert the image. The control of their work results with the need to solve coordination problem. The paper summarizes the model of coordination of resource allocation in relation to the task of synchronizing parallel processes; the genetic algorithm of coordination developed, its adequacy verified in relation to the process of parallel image processing.

  9. Alexander Dalgarno

    Science.gov (United States)

    Fox, Jane L.

    Alex Dalgarno saved my career. I entered the Graduate School at Harvard in the Chemistry Department in September of 1973 from the University of Michigan, where I had (unfortunately) majored in Chemistry. Chemistry is considered a "laboratory science" but I had no talent in the laboratory. I had merely fallen in love with the ideal gas law in high school, and I had stubbornly allowed this to determine my course of studies, most of which had nothing to do with the ideal gas law, and much of which was focused on laboratory studies...

  10. Trace element analysis of Alexander the Great's silver tetradrachms minted in Macedonia

    Science.gov (United States)

    Kallithrakas-Kontos, N.; Katsanos, A. A.; Touratsoglou, J.

    2000-11-01

    The coinage of Alexander the Great presents a special interest because of its international character in the frame of the ancient times. At least 31 mints (from Aigai to Babylon and from Pella to Alexandreia) operated in the vast state, which was created by Alexander in just over 10 years (334-323 BC). Impressive quantities of tetradrachms were consequently minted for the economic affairs of an expanding state. The mints continued to be active and after the premature death of the Macedonian king, producing among others and tetradrachms in his name. The elemental chemical composition of silver tetradrachms minted in Amphipolis as well as in other Macedonian Greek cities was analysed by energy dispersive X-ray fluorescence (EDXRF), and 12 elements were determined. The problem of the patina (silver corrosion layer) effects on the results was examined by analysis before and after the corrosion product removal. From the results of the chemical composition, a similar numismatic policy is deduced for all the analysed coin as well as metal provenance indications for some of the coins.

  11. Identität und Differenz Goethes Faust und Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Heinz Krumpel

    2007-04-01

    Full Text Available Article in German, Abstracts in English, Spanish and GermanIn the article “Identity and difference between Goethe`s Faust and Alexander von Humboldt” the issue of how much Faust is contained in Humboldt and in which way Goethe`s Faust has to be related to Alexander von Humboldt is discussed. Here the connection of activity, knowledge and vision as well as the relationship between humans and nature are central to the examination. Goethe and Humboldt were greatly influenced by the enlightenment. Their ideas and visions show us today that modernity is an incomplete project. In Goethe`s Faust the question of the essence of mankind is posed because there is a hint of Faust and Mephisto in each human. With Humboldt those principles acted among other things as a driving force for greater productitivity and the extraction of knowledge. Even though Faust did not fail in his bet with Mephisto, on the other hand he also did not win. Humboldt, however, would have won the bet. Considering the global ecological crisis and regional conflicts today the idea of the relation of Goethe´s Faust and Humboldt has an astonishing relevance.

  12. UKRAINIAN HUT AS THE ARCHETYPAL MODEL IN THE WORKS OF ALEXANDER DOVZHENKO

    Directory of Open Access Journals (Sweden)

    YEVSEYEVA H. P.

    2016-04-01

    Full Text Available Raising of problem. Archetypal model of national dwelling is the basic and determining element of material and spiritual culture, because design features, decorative artwork, ornamentation housing, amulet symbols as elements of the home’s interior structure the ideological system and act as a kind of code for understanding the primary landmark of the national worldview. The purpose. Identify the main components of the design features of the Ukrainian house image on the material of the story "Izba" and the tale "the Enchanted Desna" Alexander Dovzhenko. Conclusions. Research of reproduction features of the Ukrainian hut image in the art world of Alexander Dovzhenko allowed to structure arhetipo model of national dwelling, which appears as the center of the universe and as the source of all organic life forms. Antagonism of the profane and of the sacred can be solved through a paradoxical focus of such binary oppositions as power/spiritual strength, closeness/openness. An important means of the essential characteristics revealing of the house image is the apophaticism device.

  13. Cementable implant-supported prosthesis, serial extraction, and serial implant installation: case report.

    Science.gov (United States)

    Rosen, Harry; Gornitsky, Mervyn

    2004-12-01

    Cement-retained implant-supported prostheses are particularly indicated where access for screw placement is limited or impossible like in posterior locations or where there is limited jaw opening. The patient in this case report suffered from limited jaw opening as a result of a long history of temporomandibular joint ankylosis related to hemophilia. Cement-retained implant-supported prostheses coupled with serial extraction, serial implant installations, and chairside provisional restorations made uneventful treatment possible.

  14. Book review: An Introduction to Audio Content Analysis: Applications in Signal Processing and Music Informatics by Alexander Lerch

    DEFF Research Database (Denmark)

    Sturm, Bob L.

    2013-01-01

    A critical review of the book: An Introduction to Audio Content Analysis: Applications in Signal Processing and Music Informatics, by Alexander Lerch, October 2012, Wiley-IEEE Press. ISBN: 978-1-118-26682-3, Hardcover, 272 pages, 503 references. List price $125.00......A critical review of the book: An Introduction to Audio Content Analysis: Applications in Signal Processing and Music Informatics, by Alexander Lerch, October 2012, Wiley-IEEE Press. ISBN: 978-1-118-26682-3, Hardcover, 272 pages, 503 references. List price $125.00...

  15. Serial position markers in space: visuospatial priming of serial order working memory retrieval.

    Directory of Open Access Journals (Sweden)

    Maya De Belder

    Full Text Available Most general theories on serial order working memory (WM assume the existence of position markers that are bound to the to-be-remembered items to keep track of the serial order. So far, the exact cognitive/neural characteristics of these markers have remained largely underspecified, while direct empirical evidence for their existence is mostly lacking. In the current study we demonstrate that retrieval from verbal serial order WM can be facilitated or hindered by spatial cuing: begin elements of a verbal WM sequence are retrieved faster after cuing the left side of space, while end elements are retrieved faster after cuing the right side of space. In direct complement to our previous work--where we showed the reversed impact of WM retrieval on spatial processing--we argue that the current findings provide us with a crucial piece of evidence suggesting a direct and functional involvement of space in verbal serial order WM. We outline the idea that serial order in verbal WM is coded within a spatial coordinate system with spatial attention being involved when searching through WM, and we discuss how this account can explain several hallmark observations related to serial order WM.

  16. Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia

    Directory of Open Access Journals (Sweden)

    K Rennis Davis

    2015-01-01

    Full Text Available Pulmonary alveolar proteinosis (PAP is a rare disease, characterized by alveolar accumulation of surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages. Mainstay of treatment is whole lung lavage, which requires general anesthesia. Herein, we report a case of primary PAP, successfully treated with serial bronchoscopic lung lavages under local anesthesia.

  17. Serial pulmonary function tests to diagnose COPD in chronic heart failure

    NARCIS (Netherlands)

    Minasian, A.G.; Elshout, F.J.J. van den; Dekhuijzen, P.N.R.; Vos, P.J.E.; Willems, F.F.; Bergh, P.J.P.C. van den; Heijdra, Y.F.

    2014-01-01

    BACKGROUND: It is unknown whether serial pulmonary function tests are necessary for the correct diagnosis of chronic obstructive pulmonary disease (COPD) in patients with stable non-congested chronic heart failure (CHF). The aim of this study was to determine the prevalence of COPD in outpatients wi

  18. A study of serial ranks via random graphs

    OpenAIRE

    Haeusler, Erich; Mason, David M.; Turova, Tatyana S.

    2000-01-01

    Serial ranks have long been used as the basis for nonparametric tests of independence in time series analysis. We shall study the underlying graph structure of serial ranks. This will lead us to a basic martingale which will allow us to construct a weighted approximation to a serial rank process. To show the applicability of this approximation, we will use it to prove two very general central limit theorems for Wald-Wolfowitz-type serial rank statistics.

  19. The OCLC Serials Sub-System: A First Evaluation.

    Science.gov (United States)

    Edgar, Neal L.; And Others

    This examination of the OCLC serials control sub-system points to positive and negative aspects of the OCLC system as they relate to serials, and evaluates the system's serials cataloging capabilities. While this report assumes a knowledge of the basic operations of OCLC, it describes the system in general, its function in cataloging, and its…

  20. A Survey of Electronic Serials Managers Reveals Diversity in Practice

    Directory of Open Access Journals (Sweden)

    Laura Costello

    2014-09-01

    Full Text Available A Review of: Branscome, B. A. (2013. Management of electronic serials in academic libraries: The results of an online survey. Serials Review, 39(4, 216-226. http://dx.doi.org/10.1016/j.serrev.2013.10.004 Abstract Objective – To examine industry standards for the management of electronic serials and measure the adoption of electronic serials over print. Design – Survey questionnaire. Setting – Email lists aimed at academic librarians working in serials management. Subjects – 195 self-selected subscribers to serials email lists. Methods – The author created a 20 question survey that consisted primarily of closed-ended questions pertaining to the collection demographics, staff, budget, and tools of serials management groups in academic libraries. The survey was conducted via Survey Monkey and examined using the analytical features of the tool. Participants remained anonymous and the survey questions did not ask them to reveal identifiable information about their libraries. Main Results – Collection demographics questions revealed that 78% of surveyed librarians estimated that print-only collections represented 40% or fewer of their serials holdings. The author observed diversity in the factors that influence print to digital transitions in academic libraries. However 71.5% of participants indicated that publisher technology support like IP authentication was required before adopting digital subscriptions. A lack of standardization also marked serials workflows, department responsibilities, and department titles. The author did not find a correlation between serials budget and the enrollment size of the institution. Participants reported that they used tools from popular serials management vendors like Serials Solutions, Innovative Interfaces, EBSCO, and Ex Libris, but most indicated that they used more than one tool for serials management. Participants specified 52 unique serials management products used in their libraries. Conclusion

  1. Stochastic modeling of a serial killer

    CERN Document Server

    Simkin, M V

    2012-01-01

    We analyze the time pattern of the activity of a serial killer, who during twelve years had murdered 53 people. The plot of the cumulative number of murders as a function of time is of "Devil's staircase" type. The distribution of the intervals between murders (step length) follows a power law with the exponent of 1.4. We propose a model according to which the serial killer commits murders when neuronal excitation in his brain exceeds certain threshold. We model this neural activity as a branching process, which in turn is approximated by a random walk. As the distribution of the random walk return times is a power law with the exponent 1.5, the distribution of the inter-murder intervals is thus explained. We confirm analytical results by numerical simulation.

  2. Novel Optimized Designs for QCA Serial Adders

    Directory of Open Access Journals (Sweden)

    A. Mostafaee

    2017-02-01

    Full Text Available Quantum-dot Cellular Automata (QCA is a new and efficient technology to implement logic Gates and digital circuits at the nanoscale range. In comparison with the conventional CMOS technology, QCA has many attractive features such as: low-power, extremely dense and high speed structures. Adders are the most important part of an arithmetic logic unit (ALU. In this paper, four optimized designs of QCA serial adders are presented. One of the proposed designs is optimized in terms of the number of cells, area and delay without any wire crossing methods. Also, two new designs of QCA serial adders and a QCA layout equivalent to the internal circuit of TM4006 IC are presented. QCADesigner software is used to simulate the proposed designs. Finally, the proposed QCA designs are compared with the previous QCA, CNTFET-based and CMOS technologies.

  3. Object Serialization and Deserialization Using XML

    CERN Document Server

    Le Goff, J M; Hassan, W; Kovács, Z; Martin, P; McClatchey, R; Stockinger, H E; Willers, Ian Malcolm

    2001-01-01

    Interoperability of potentially heterogeneous databases has been an ongoing research issue for a number of years in the database community. With the trend towards globalization of data location and data access and the consequent requirement for the coexistence of new data stores with legacy systems, the cooperation and data interchange between data repositories has become increasingly important. The emergence of the eXtensible Markup Language (XML) as a database independent representation for data offers a suitable mechanism for transporting data between repositories. This paper describes a research activity within a group at CERN (called CMS) towards identifying and implementing database serialization and deserialization methods that can be used to replicate or migrate objects across the network between CERN and worldwide centres using XML to serialize the contents of multiple objects resident in object-oriented databases.

  4. Automated detection of multiple sclerosis lesions in serial brain MRI

    Energy Technology Data Exchange (ETDEWEB)

    Llado, Xavier; Ganiler, Onur; Oliver, Arnau; Marti, Robert; Freixenet, Jordi [University of Girona, Computer Vision and Robotics Group, Girona (Spain); Valls, Laia [Dr. Josep Trueta University Hospital, Department of Radiology, Girona (Spain); Vilanova, Joan C. [Girona Magnetic Resonance Center, Girona (Spain); Ramio-Torrenta, Lluis [Dr. Josep Trueta University Hospital, Institut d' Investigacio Biomedica de Girona, Multiple Sclerosis and Neuroimmunology Unit, Girona (Spain); Rovira, Alex [Vall d' Hebron University Hospital, Magnetic Resonance Unit, Department of Radiology, Barcelona (Spain)

    2012-08-15

    Multiple sclerosis (MS) is a serious disease typically occurring in the brain whose diagnosis and efficacy of treatment monitoring are vital. Magnetic resonance imaging (MRI) is frequently used in serial brain imaging due to the rich and detailed information provided. Time-series analysis of images is widely used for MS diagnosis and patient follow-up. However, conventional manual methods are time-consuming, subjective, and error-prone. Thus, the development of automated techniques for the detection and quantification of MS lesions is a major challenge. This paper presents an up-to-date review of the approaches which deal with the time-series analysis of brain MRI for detecting active MS lesions and quantifying lesion load change. We provide a comprehensive reference source for researchers in which several approaches to change detection and quantification of MS lesions are investigated and classified. We also analyze the results provided by the approaches, discuss open problems, and point out possible future trends. Lesion detection approaches are required for the detection of static lesions and for diagnostic purposes, while either quantification of detected lesions or change detection algorithms are needed to follow up MS patients. However, there is not yet a single approach that can emerge as a standard for the clinical practice, automatically providing an accurate MS lesion evolution quantification. Future trends will focus on combining the lesion detection in single studies with the analysis of the change detection in serial MRI. (orig.)

  5. Serials collection management in recessionary times

    CERN Document Server

    Lawson, Karen G

    2013-01-01

    Strategic planning, collaboration, continual stewardship, best practices, and re-engineering can provide librarians with a toolkit of innovative strategies that meets the worst of economic times with bold, persistent experimentation.This book covers the implications for libraries of a broad range of technological and economic challenges. These challenges include the fallout from the global economic crisis, the positioning of usage statistics, the advent of open access scholarship, database management, responding to budgetary constrictions and general access to serials.Taken as

  6. Serial correlation in the Italian futures market

    Science.gov (United States)

    Bianco, Simone; Reno, Roberto

    2005-05-01

    We study the serial correlation of high-frequency intraday returns on the Italian stock index futures (FIB30) in the period 2000-2002. We adopt three different methods of analysis: the spectral density via Fast Fourier Transform, Detrended Fluctuation Analysis (DFA) and the Variance Ratio test. We find that intraday autocorrelation is mostly negative for time scales lower than 20 minutes, but we support the efficiency of the Italian futures market.

  7. Monitor Forest Fires with FY Serial Satellites

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Remote sensing as the measure to monitor disasters has the advantage of temporal resolution and large scale. Since "5.6 catastrophe" in 1987, China began to monitor forest fires broadly. In the summer of 2002, many forest/grass fires occurred in the Daxing'anling Mountains, and the damage was very heavy. In the forest fires fighting, the meteorological satellites play an important role in monitoring the fires. Especially the FY serial meteorological satellites have the advantage of large scale monitorin...

  8. Serial Pixel Analog-to-Digital Converter

    Energy Technology Data Exchange (ETDEWEB)

    Larson, E D

    2010-02-01

    This method reduces the data path from the counter to the pixel register of the analog-to-digital converter (ADC) from as many as 10 bits to a single bit. The reduction in data path width is accomplished by using a coded serial data stream similar to a pseudo random number (PRN) generator. The resulting encoded pixel data is then decoded into a standard hexadecimal format before storage. The high-speed serial pixel ADC concept is based on the single-slope integrating pixel ADC architecture. Previous work has described a massively parallel pixel readout of a similar architecture. The serial ADC connection is similar to the state-of-the art method with the exception that the pixel ADC register is a shift register and the data path is a single bit. A state-of-the-art individual-pixel ADC uses a single-slope charge integration converter architecture with integral registers and “one-hot” counters. This implies that parallel data bits are routed among the counter and the individual on-chip pixel ADC registers. The data path bit-width to the pixel is therefore equivalent to the pixel ADC bit resolution.

  9. Las construcciones verbales seriales en mapuche

    Directory of Open Access Journals (Sweden)

    Ana Fernández-Garay

    2009-06-01

    Full Text Available Este artículo analiza las construcciones verbales seriales (CVS del mapudungun, lengua indígena hablada en el sur de la República Argentina, sobre todo en las provincias de La Pampa, Neuquén, Río Negro y Chubut. Los estudios tradicionales del mapudungun han tratado los verbos conformadospor dos o más raíces verbales como lexemas compuestos. A partir de la perspectiva tipológica, que define las construcciones verbales seriales como una secuencia de verbos que funciona como un predicado único, sin presentar elementos coordinantes ni subordinantes entre ellos, se las analiza estableciendo los distintos tipos de CVS, sus valores semánticos, así como su frecuencia de aparición en los corpora sobre los que se basanuestro trabajo. -- This article analyzes the serial verb constructions (SVC of Mapudungun, an indigenous language spoken in the southern region of Argentina —mainly in the provinces of La Pampa, Neuquén, Río Negro y Chubut.Traditional investigations of Mapudungun have considered verbs constituted by two or more verbal roots as complex lexemes. From a typological trend, which defines SVC as a sequence of verbs that functions as a unique predicate, without presenting coordination or subordination elements betweenthem, we analyze Mapudungun SVC and, thus, establish a typology, their semantic values and the appearance frequency in the corpora we gathered for this investigation.

  10. Alexander Claver, Dutch Commerce and Chinese Merchants in Java. Colonial Relationships in Trade and Finance, 1800-1942

    Directory of Open Access Journals (Sweden)

    Kwee Hui Kian

    2015-09-01

    Full Text Available Alexander Claver, Dutch Commerce and Chinese Merchants in Java. Colonial Relationships in Trade and Finance, 1800-1942 (Verhandelingen van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde 291; Leiden, Boston: Brill, 2014, xxiv + 442 pp., ISBN 978 90 04 25657 6.

  11. Brookhaven Lab physicists Edward Beebe and Alexander Pikin win 'Brightness Award' for achievement in ion source physics and technology

    CERN Multimedia

    2003-01-01

    "Edward Beebe and Alexander Pikin, physicists at the U.S. Department of Energy's Brookhaven National Laboratory, have been awarded the Ion Source Prize, known as the "Brightness Award," which recognizes and encourages innovative and significant recent achievements in the fields of ion source physics and technology" (1 page).

  12. The Four Domains of Moral Education: The Contributions of Dewey, Alexander and Goleman to a Comprehensive Taxonomy.

    Science.gov (United States)

    Zigler, Ronald Lee

    1998-01-01

    Attempts to place a neglected dimension of John Dewey's work into its proper context. Examines the works of Dewey, F. Matthias Alexander, and Daniel Goldman to create four domains that must be addressed by a truly comprehensive model of moral education: direct external, indirect external, direct internal, and indirect internal. (DSK)

  13. Mythorealistic Concept of "Beautiful Lady" in the Structure of the Author's Identity (Based on the Diaries of Alexander Blok)

    Science.gov (United States)

    Minets, Diana

    2016-01-01

    The present paper deals with the diaries of Alexander Blok dated 1901-1921 reflecting the process of the writer's self-identification. During 20 years under the influence of various social and cultural situations Blok's "Self-Conception" is undergoing significant changes. The vector of these changes shows the complicated evolution of the…

  14. Growing Community: The Impact of the Stephanie Alexander Kitchen Garden Program on the Social and Learning Environment in Primary Schools

    Science.gov (United States)

    Block, Karen; Gibbs, Lisa; Staiger, Petra K.; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

    2012-01-01

    This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has…

  15. Speciation despite globally overlapping distributions in Penicillium chrysogenum: the population genetics of Alexander Fleming’s lucky fungus

    Science.gov (United States)

    Eighty years ago, Alexander Fleming described the antibiotic effects of a fungus that had contaminated his bacterial culture, kick starting the antimicrobial revolution. The fungus was later ascribed to a globally distributed asexual species, Penicillium chrysogenum. Recently, the species has been...

  16. NATUREZA EM ALEXANDER VON HUMBOLDT: entre a ontologia e o empirismo

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Vitte

    2010-01-01

    Full Text Available El artículo analiza el papel del materialismo y la Naturphilosophie en la construcción del concepto de naturaleza en Alexander von Humboldt. De la reelaboración de las concepciones empirista y materialista de la naturaleza y entrar en un concepción ontológica, los avances de Humboldt y permite un análisis más profundo en la superfi cie de la tierra y sus procesos, crea una nueva ciencia y la creación de la imagen moderna de una naturaleza más allá del mecanismo. Geografía, es este producto y refl exión requiere una sólida base metafísica que permitió a la misma Humboldt recrear los conceptos de la Tierra y el Mundo.

  17. Die Entstehung einer Legende. Alexander von Humboldts angeblicher Ausspruch über Salzburg.

    Directory of Open Access Journals (Sweden)

    Robert Hoffmann

    2006-04-01

    Full Text Available Article in German, Abstract in English.This paper sheds light on the history of the quotation “I regard the environs of Salzburg, Naples, and Constantinople as the most beautiful on earth”, which is usually attributed to Alexander von Humboldt. The author shows that Humboldt’s alleged praise of Salzburg first appeared around 1870, and thus the quotation cannot be regarded as authentic. As a local legend it was meant to connect permanently the famous name of Humboldt with that of the growing centre of tourism. The circumstances under which the quotation found its way into the literature remain to be investigated; however, it seems clear that this can be seen as a typical example of what Eric Hobsbawm has called „invention of tradition“. Invented traditions – this might comfort the tourist industry of Salzburg – have particularly long lives.

  18. Political Economy, Alexander Von Humboldt, and Mexico’s 1810 and 1910 Revolutions

    Directory of Open Access Journals (Sweden)

    Richard Weiner

    2010-08-01

    Full Text Available This article, which is informed by Steve Pincus’ scholarship on revolution, engages in the novelendeavor of comparing Mexico’s 1810 and 1910 Revolutions. The article explores broad parallelsbetween the two upheavals, and highlights significant features of Mexico’s Revolutions thatscholars have ignored. Alexander von Humboldt’s Ensayo político sobre el reino de la NuevaEspaña proved to be influential in both of Mexico’s Revolutions, albeit in distinct ways in eachcase. Conflicts over political economy were also central aspects of each Revolution. Theseeconomic disagreements sometimes pitted revolutionists against traditionalists, and sometimesdivided revolutionists against each other. Even if revolutionists differed in terms of economicvisions, they were all “statists” in the sense that they designated an important role for governmentin fostering economic and social modernization.

  19. Alexander Numan (1780-1852 en de veredeling van de Nederlandse schapenrassen

    Directory of Open Access Journals (Sweden)

    Jesper Oldenburger

    2015-10-01

    Full Text Available Alexander Numan and the improvement of the Dutch sheep breedsAlexander Numan’s life and work provide a splendid illustration of the early nineteenth-century Dutch scientist’s view of the role of science and scientists in society. As a professor at the Utrecht veterinary school he spent a substantial part of his time on a practical endeavour: the improvement of the wool quality of the Dutch sheep breeds. He did not confine his activities to the scientific aspects only, but aimed to obtain the active involvement of all relevant stakeholders in his project: the government, the sheep farmers and the wool industry.In the literature, Numan’s project is seen as a failure: the stakeholders were skeptical about his project from the beginning, as wool improvement was seen as a misguided aim. The Dutch wool industry was perfectly satisfied with the quality of the Dutch wool, and the trend among sheep breeders was to improve their sheeps’ meat meat quality rather than their wool. Eventually, the government withdrew its indispensable support.Nevertheless, Numan clung doggedly to the aim he had set himself, and the question we want to answer is this paper is why. We argue that the answer is to be found in Numan’s view of the role of science in society. His motives were not merely economic, but, first and foremost, of a moral nature. Wool quality, for him, was a measure of the level of civilization a country had reached. Social and cultural progress went hand in hand with the availability of higher quality clothing, the raw materials for which the Dutch sheep were as yet unable to provide. By providing these materials Numan was convinced to contribute directly to the well-being and cultural enhancement of the Dutch population, an objective that was characteristic of the self-fashioned private and public persona of the early nineteenth-century Dutch scientist.

  20. Rapid serial visual presentation design for cognition

    CERN Document Server

    Spence, Robert

    2013-01-01

    A powerful new image presentation technique has evolved over the last twenty years, and its value demonstrated through its support of many and varied common tasks. Conceptually, Rapid Serial Visual Presentation (RSVP) is basically simple, exemplified in the physical world by the rapid riffling of the pages of a book in order to locate a known image. Advances in computation and graphics processing allow RSVP to be applied flexibly and effectively to a huge variety of common tasks such as window shopping, video fast-forward and rewind, TV channel selection and product browsing. At its heart is a

  1. Automated Serial Sectioning for 3D Reconstruction

    Science.gov (United States)

    Alkemper, Jen; Voorhees, Peter W.

    2003-01-01

    Some aspects of an apparatus and method for automated serial sectioning of a specimen of a solder, aluminum, or other relatively soft opaque material are discussed. The apparatus includes a small milling machine (micromiller) that takes precise, shallow cuts (increments of depth as small as 1 micron) to expose successive sections. A microscope equipped with an electronic camera, mounted in a fixed position on the micromiller, takes pictures of the newly exposed specimen surface at each increment of depth. The images are digitized, and the resulting data are subsequently processed to reconstruct three-dimensional (3D) features of the specimen.

  2. Galileo - The Serial-Production AIT Challenge

    Science.gov (United States)

    Ragnit, Ulrike; Brunner, Otto

    2008-01-01

    The Galileo Project is one of the most demanding projects of ESA, being Europe's autarkic navigation system and a constellation composed of 30 satellites. This presentation points out the different phases of the project up to the full operational capability and the corresponding launch options with respect to launch vehicles as well as launch configurations. One of the biggest challenges is to set up a small serial 'production line' for the overall integration and test campaign of satellites. This production line demands an optimization of all relevant tasks, taking into account also backup and recovery actions. A comprehensive AIT concept is required, reflecting a tightly merged facility layout and work flow design. In addition a common data management system is needed to handle all spacecraft related documentation and to have a direct input-out flow for all activities, phases and positions at the same time. Process optimization is a well known field of engineering in all small high tech production lines, nevertheless serial production of satellites are still not the daily task in space business and therefore new concepts have to be put in place. Therefore, and in order to meet the satellites overall system optimization, a thorough interface between unit/subsystem manufacturing and satellite AIT must be realized to ensure a smooth flow and to avoid any process interruption, which would directly lead to a schedule impact.

  3. Breaking the indexing ambiguity in serial crystallography.

    Science.gov (United States)

    Brehm, Wolfgang; Diederichs, Kay

    2014-01-01

    In serial crystallography, a very incomplete partial data set is obtained from each diffraction experiment (a `snapshot'). In some space groups, an indexing ambiguity exists which requires that the indexing mode of each snapshot needs to be established with respect to a reference data set. In the absence of such re-indexing information, crystallographers have thus far resorted to a straight merging of all snapshots, yielding a perfectly twinned data set of higher symmetry which is poorly suited for structure solution and refinement. Here, two algorithms have been designed for assembling complete data sets by clustering those snapshots that are indexed in the same way, and they have been tested using 15,445 snapshots from photosystem I [Chapman et al. (2011), Nature (London), 470, 73-77] and with noisy model data. The results of the clustering are unambiguous and enabled the construction of complete data sets in the correct space group P63 instead of (twinned) P6322 that researchers have been forced to use previously in such cases of indexing ambiguity. The algorithms thus extend the applicability and reach of serial crystallography.

  4. Serial dilution microchip for cytotoxicity test

    Science.gov (United States)

    Bang, Hyunwoo; Lim, Sun Hee; Lee, Young Kyung; Chung, Seok; Chung, Chanil; Han, Dong-Chul; Chang, Jun Keun

    2004-08-01

    Today's pharmaceutical industry is facing challenges resulting from the vast increases in sample numbers produced by high-throughput screening (HTS). In addition, the bottlenecks created by increased demand for cytotoxicity testing (required to assess compound safety) are becoming a serious problem. We have developed a polymer PDMS (polydimethylsiloxane) based microfluidic device that can perform a cytotoxicity test in a rapid and reproducible manner. The concept that the device includes is well adjustable to automated robots in huge HTS systems, so we can think of it as a potential dilution and delivery module. Cytotoxicity testing is all about the dilution and dispensing of a drug sample. Previously, we made a PDMS based microfluidic device which automatically and precisely diluted drugs with a buffer solution with serially increasing concentrations. This time, the serially diluted drug solution was directly delivered to 96 well plates for cytotoxicity testing. Cytotoxic paclitaxel solution with 2% RPMI 1640 has been used while carrying out cancerous cell based cytotoxicity tests. We believe that this rapid and robust use of the PDMS microchip will overcome the growing problem in cytotoxicity testing for HTS.

  5. Serial evaluation of {sup 123}I-BMIPP/{sup 201}Tl myocardial single-proton emission computed tomography after coronary stent implantation in ischemic heart disease. Association with recovery of left ventricular function

    Energy Technology Data Exchange (ETDEWEB)

    Shimazu, Yoshihisa; Taniguchi, Ikuo; Wagatsuma, Kenji; Yamazaki, Tatsuo [Jikei Univ., Tokyo (Japan). School of Medicine

    2000-11-01

    Coronary stent implantation is often used to treat ischemic heart disease. However, few studies have evaluated myocardial viability with single-proton emission computed tomography (SPECT) and both thallium and {beta}-methyl-iodophenyl-pentadecanoic acid (BMIPP) after coronary stent implantation. Forty patients (30 men and 10 women, 64.8{+-}9.3 years old) who had undergone successful stent implantation were enrolled. Twenty-two patients had angina pectoris (AP) and 18 patients had acute myocardial infarction (AMI). We performed BMIPP and thallium SPECT immediately after coronary stent implantation and at 3 months follow-up and compared the results with left ventriculograms. Myocardial SPECT images were divided into 17 segments, after which defect scores (1 to 5) were assigned to each segment and summed to obtain a total defect score (TDS). Left ventriculograms were divided into 9 segments, each of which was given a wall motion score (WMS; 1 to 5). In patients with either AP or AMI, the TDS of BMIPP and thallium SPECT images were significantly better at 3 months follow-up than immediately after stent implantation. In patients with AP, improvements in TDS on BMIPP and thallium SPECT were not associated with improvements in WMS. In patients with AMI, improvements in TDS on BMIPP SPECT were correlated with improvements in WMS (r=0.69, p<0.01) and in left ventricular ejection fraction (r=0.70, p<0.01), and improvements in TDS on thallium SPECT were correlated with improvements in WMS (r=0.64, p<0.01) but were not associated with improvements in left ventricular ejection fraction. In conclusion, a decrease in BMIPP myocardial uptake in patients with AP suggests previous episodes of severe myocardial ischemia. Improvements in BMIPP uptake in patients with AMI may indicate recovery of left ventricular function. Coronary stent implantation for severe myocardial ischemia contributes to improvements in myocardial viability. (author)

  6. Representation of the serial killer on the Italian Internet.

    Science.gov (United States)

    Villano, P; Bastianoni, P; Melotti, G

    2001-10-01

    The representation of serial killers was examined from the analysis of 317 Web pages in the Italian language to study how the psychological profiles of serial killers are described on the Italian Internet. The correspondence analysis of the content of these Web pages shows that in Italy the serial killer is associated with words such as "monster" and "horror," which suggest and imply psychological perversion and aberrant acts. These traits are peculiar for the Italian scenario.

  7. Consistent 4D Brain Extraction of Serial Brain MR Images

    OpenAIRE

    Wang, Yaping; Li, Gang; Nie, Jingxin; Yap, Pew-Thian; Guo, Lei; Shen, Dinggang

    2013-01-01

    Accurate and consistent skull stripping of serial brain MR images is of great importance in longitudinal studies that aim to detect subtle brain morphological changes. To avoid inconsistency and the potential bias introduced by independently performing skull-stripping for each time-point image, we propose an effective method that is capable of skull-stripping serial brain MR images simultaneously. Specifically, all serial images of the same subject are first affine aligned in a groupwise mann...

  8. Berglinien im Vergleich. Bemerkungen zu einem klimageografischen Diagramm Alexander von Humboldts

    Directory of Open Access Journals (Sweden)

    Birgit Schneider

    2013-04-01

    Full Text Available Zusammenfassung Der Artikel analysiert aus bildwissenschaftlicher und historischer Perspektive die unveröffentlichte Skizze zu einem Bergdiagramm aus dem handschriftlichen Nachlass Alexander von Humboldts. Das mehrfach beklebte Skizzenblatt stand im Zentrum klimageografischer Fragestellungen nach den Gründen für die weltweit unterschiedlich hohen Schneegrenzen in Gebirgen. Aufgrund des unfertigen, skizzenhaften Charakters des Diagramms lassen sich Fragen über den Forschungskontext des Diagramms, den epistemischen Stellenwert zeichnerischer Praktiken sowie über die heuristische Rolle der Berge und ihrer charakteristischen Profillinien in Humboldts Forschungen stellen. Gezeigt wird, wie das visuelle Denken und das Interesse Humboldts an neuen grafischen Methoden zu einer wichtigen Bedingung wurden, um die holistische Synopsis der Welt als ökologisches System erforschen und darstellen zu können. Abstract The article analyses from a visual studies and historical perspective the unpublished sketch of a mountain profile found among the handwritten papers of Alexander von Humboldt’s estate. The small sheet of sketches, with its pasted additions, was at the heart of climatic-geographic academic enquiry into the reasons for worldwide differences in the levels of mountain snow lines. The unfinished, sketchy nature of the diagramme raises questions about its research context, about the epistemic value of draughtsmanship practice and about the heuristic role of mountains and their characteristic profiles in Humboldt’s research. It becomes evident how Humboldt’s visual logic and his interest in new forms of graphics became important factors in investigation and depiction of the world as an ecological system. Resumen En el artículo se analizan los bocetos sin publicar de perspectivas históricas y de la ciencia de la imagen del diagrama montañoso de las obras póstumas escritas a mano de Alexander von Humboldt. La hoja de bocetos pegada de

  9. A psychological profile of a serial killer: a case report.

    Science.gov (United States)

    Dogra, T D; Leenaars, Antoon A; Chadha, R K; Manju, Mehta; Lalwani, Sanjeev; Sood, Mamta; Lester, David; Raina, Anupuma; Behera, C

    2012-01-01

    Serial killers have always fascinated society. A serial killer is typically defined as a perpetrator who murders three or more people over a period of time. Most reported cases of serial killers come from the United States and Canada. In India, there are few reported cases. We present, to the best of our knowledge, the first Indian case in the literature. The present case is of a 28-year-old man, Surinder Koli. The Department of Forensic Medicine & Toxicology, All India Institute of Medical Sciences, New Delphi handled the forensic study. We present a most unique psychological investigation into the mind of a serial killer.

  10. Malignant sex and aggression: an overview of serial sexual homicide.

    Science.gov (United States)

    Myers, W C; Reccoppa, L; Burton, K; McElroy, R

    1993-01-01

    Serial murderers have attracted considerable attention in the popular press and criminal justice field, but scientific literature about these individuals is limited. This article provides an overview, from a psychiatric perspective, of serial sexual homicide, one type of serial killing. Characteristics of this type of murder and of these offenders are discussed. Defining qualities and diagnoses applicable to serial sexual killers are reviewed. Various etiologic theories are discussed, with emphasis on the role of fantasy and psychodynamic explanations. Governmental agencies involved in combating this type of crime, along with the role of mental health professionals in criminal profiling, are presented. Finally, the authors explore the reaction of society to this phenomenon.

  11. [Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003

    Index Scriptorium Estoniae

    Garleff, Michael, 1940-

    2011-01-01

    Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003. Heidelberg : Universitätsverlag Winter, 2007

  12. Unterwegs zum Weltbewußtsein. Alexander von Humboldts Wissenschaftsverständnis und die Entstehung einer ethisch fundierten Weltanschauung

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    Ottmar Ette

    2000-10-01

    Full Text Available Article in German, Abstracts in English and Spanish. Towards Global Consciousness. Alexander von Humboldt's Conception of Science and the emerging ethical Weltanschauung. In the context of recent reflections upon global ethics (Hans Küng, global democracy (Otfried Höffe and a new cultural situation after the end of the Cold War (Clifford Geertz, Alexander von Humboldt's concept of global consciousness (Weltbewußtsein marks a decisive point in the ungoing process of the construction of a new ethics of globalization. This article tries to show how Humboldt's transdisciplinary and intercultural conception of sience as WorldWideWeb integrates Kant's philosophical visions of global political institutions and formulates a critique of the non-empirical foundations of Hegel's teleological Weltanschauung. From his Visions of Nature and his Personal Narrative to his Cosmos, Humboldt's theory and practice of science help us to find a new ethos and new answers to the contemporary questions of divergent modernities.

  13. Serial binary interval ratios improve rhythm reproduction

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    Xiang eWu

    2013-08-01

    Full Text Available Musical rhythm perception is a natural human ability that involves complex cognitive processes. Rhythm refers to the organization of events in time, and musical rhythms have an underlying hierarchical metrical structure. The metrical structure induces the feeling of a beat and the extent to which a rhythm induces the feeling of a beat is referred to as its metrical strength. Binary ratios are the most frequent interval ratio in musical rhythms. Rhythms with hierarchical binary ratios are better discriminated and reproduced than rhythms with hierarchical non-binary ratios. However, it remains unclear whether a superiority of serial binary over non-binary ratios in rhythm perception and reproduction exists. In addition, how different types of serial ratios influence the metrical strength of rhythms remains to be elucidated. The present study investigated serial binary vs. non-binary ratios in a reproduction task. Rhythms formed with exclusively binary (1:2:4:8, non-binary integer (1:3:5:6, and non-integer (1:2.3:5.3:6.4 ratios were examined within a constant meter. The results showed that the 1:2:4:8 rhythm type was more accurately reproduced than the 1:3:5:6 and 1:2.3:5.3:6.4 rhythm types, and the 1:2.3:5.3:6.4 rhythm type was more accurately reproduced than the 1:3:5:6 rhythm type. Further analyses showed that reproduction performance was better predicted by the distribution pattern of event occurrences within an inter-beat interval, than by the coincidence of events with beats, or the magnitude and complexity of interval ratios. Whereas rhythm theories and empirical data emphasize the role of the coincidence of events with beats in determining metrical strength and predicting rhythm performance, the present results suggest that rhythm processing may be better understood when the distribution pattern of event occurrences is taken into account. These results provide new insights into the mechanisms underlining musical rhythm perception.

  14. Serial binary interval ratios improve rhythm reproduction.

    Science.gov (United States)

    Wu, Xiang; Westanmo, Anders; Zhou, Liang; Pan, Junhao

    2013-01-01

    Musical rhythm perception is a natural human ability that involves complex cognitive processes. Rhythm refers to the organization of events in time, and musical rhythms have an underlying hierarchical metrical structure. The metrical structure induces the feeling of a beat and the extent to which a rhythm induces the feeling of a beat is referred to as its metrical strength. Binary ratios are the most frequent interval ratio in musical rhythms. Rhythms with hierarchical binary ratios are better discriminated and reproduced than rhythms with hierarchical non-binary ratios. However, it remains unclear whether a superiority of serial binary over non-binary ratios in rhythm perception and reproduction exists. In addition, how different types of serial ratios influence the metrical strength of rhythms remains to be elucidated. The present study investigated serial binary vs. non-binary ratios in a reproduction task. Rhythms formed with exclusively binary (1:2:4:8), non-binary integer (1:3:5:6), and non-integer (1:2.3:5.3:6.4) ratios were examined within a constant meter. The results showed that the 1:2:4:8 rhythm type was more accurately reproduced than the 1:3:5:6 and 1:2.3:5.3:6.4 rhythm types, and the 1:2.3:5.3:6.4 rhythm type was more accurately reproduced than the 1:3:5:6 rhythm type. Further analyses showed that reproduction performance was better predicted by the distribution pattern of event occurrences within an inter-beat interval, than by the coincidence of events with beats, or the magnitude and complexity of interval ratios. Whereas rhythm theories and empirical data emphasize the role of the coincidence of events with beats in determining metrical strength and predicting rhythm performance, the present results suggest that rhythm processing may be better understood when the distribution pattern of event occurrences is taken into account. These results provide new insights into the mechanisms underlining musical rhythm perception.

  15. Woody Allen, serial schlemiel ?

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    Frédérique Brisset

    2011-04-01

    Full Text Available Woody Allen a développé au fil des années une persona cinématographique de schlemiel new-yorkais aisément reconnaissable par le spectateur. Elle marque nombre de ses films, qu’il y apparaisse en tant qu’acteur ou y dirige des substituts comédiens comme déclinaisons de lui-même. Si cette figure prototypique est le fondement de la sérialité dans sa filmographie, il est des traits stylistiques qui en portent trace tout au long de son œuvre : la récurrence annuelle de ses réalisations, la signature formelle symbolisée par ses génériques à la typographie singulière, le rythme de ses dialogues ponctués d’interjections et l’usage de l’autocitation sont autant de procédés qui marquent son cinéma d’un sceau très personnel. Ils fonctionnent comme des clins d’œil au spectateur qui reçoit dès lors LE Woody Allen millésimé comme une invitation à retrouver son microcosme. Ainsi la sérialité se pose comme à la fois initiale et conséquentielle de son système filmique, processus de création unique dans le cinéma américain.Woody Allen has long constructed a cinematographic persona of schlemiel New- Yorker that the audience can easily identify. It impacts most of his films, whether he stars in them or directs “substitute” actors to impersonate his character. If this prototypical figure is the basis of seriality in his cinematography, serial stylistic features can also be found all along his career: the annual recurrence of his productions, the formal signature symbolised by the typography of his singular credit titles, his rhythmical interjection-punctuated dialogues and the use of self-quotation imprint a very personal seal upon his movies. They all work as a recognition signals for the audience who thus receive THE Woody Allen vintage as an invitation to re-enter his microcosm. Seriality is then both initial and consequential to his cinematographic system, a unique creative process in American film history.

  16. Der Aachener Kongreß und das Scheitern der indischen Reisepläne Alexander von Humboldts

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    Kurt-R. Biermann

    2001-04-01

    Full Text Available Article in German, Abstracts in English and Spanish.This article argues that a "Memoir about the Spanish Colonies in South America" allegedly written by Alexander von Humboldt in 1818 for the Holy Alliance’s Conference at Aix-la-Chapelle in reality never existed and therefore could not serve as an impediment to Humboldt’s effort to visit India.

  17. Handbook of serial communications interfaces a comprehensive compendium of serial digital input/output (I/O) standards

    CERN Document Server

    Frenzel, Louis

    2015-01-01

    This book catalogs the most popular and commonly used serial-port interfaces and provides details on the specifications and the latest standards, enabling you to select an interface for a new design or verify that an interface is working correctly. Each chapter is based on a different interface and is written in an easy to follow, standard format. With this book you will learn: The most widely used serial interfacesHow to select the best serial interface for a specific application or designThe trade-offs between data rate and distance (length or range)The operation and benefits of serial

  18. The Hall Algebra of Cyclic Serial Algebra

    Institute of Scientific and Technical Information of China (English)

    郭晋云

    1994-01-01

    In this paper, orders <1 and <2 on ((Z)+)nm are introduced and also regarded as orders on the isomorphism classes of finite modules of finite .cyclic algebra R with n simple modules and all the indecomposable projective modules have length m through a one-to-one correspondence between ((Z)+)nm and the isomorphism classes of finite R modules. Using this we prove that the Hall algebra of a cyclic serial algebra is identified with its Loewy subalgebra, and its rational extension has a basis of BPW type, and is a (((Z)+)nm, <2) filtered ring with the associated graded ring as an iterated skew polynomial ring. These results are also generalized to the Hall algebra of a tube over a finite field.

  19. KANBAN allocation in a serial suply chain

    Directory of Open Access Journals (Sweden)

    Guillermo Andrés Sánchez C.

    2012-06-01

    Full Text Available The aim of this project is to simulate a Kanban system using N stages with the objective of maintaining an acceptable throughput and mean system time. The document shows the production systems where Kanban is applicable and what the potential benefits are. A serial of simulations will be done using a demand given by a poison distribution with rate λ ^ ext. The simulation aimed to find the best number of withdrawal Kanban on all stages when the values of μ (for exponential distribution of the process and λ ^ ext increase and decrease. At the end of this simulation, the best way to allocate the withdrawal Kanban over N stages with the objective of maintaining acceptable throughput and mean system time will be clearer thus the conclusions of this work will be done.

  20. PRAYER IN ALEXANDER BLOK'S LYRIC POETRY ("A GIRL WAS SINGING IN THE CHURCH CHOIR..."

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    Irina Aleksandrovna Spiridonova

    2013-11-01

    Full Text Available The article examines the genre clash of a prayer and stanzas in Alexander Blok’s poem A girl was singing in the church choir... (1905. Prayer is the main ecclesiastical source, shaping the poem’s lyric model. The genre canon of stanzas with the strophes detached substantially and compositionally, transforms the central musical theme into four scene-developments linked by dissonance. Each of the strophes in A girl was singing in the church choir... has its own semantic point (prayer – singings – illusion – enlightenment and reveals a different content of the event, intensifies and develops the tragic theme of two worlds, intended and unintended substitutions, spiritual quest and time losses. Blok’s stanzas are poetic evidence of a modern man’s exit from a prayerful concentration. The model of “conflicting synthesis” of ecclesiastical and literary genres reflects the religious/mystical opposition in symbolism aesthetics and strengthens the tragic pathos of Blok’s lyric poetry.

  1. The Russian secret service and King Alexander Obrenović of Serbia (1900-1903

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    Rajić Suzana

    2012-01-01

    Full Text Available The period of 1900-1903 saw three phases of cooperation between the Rus­sian Secret Service (Okhrana and King Alexander Obrenović of Serbia. It is safe to say that the Secret Service operated in Serbia as an extended arm of the Russian Ministry of Foreign Affairs, i.e. of its diplomatic mission in Belgrade. Its goal was to fortify the position of Russia in Serbia after King Alexander’s wedding and the departure of his father, ex-King Milan (who abdicated in 1889 in favour of his minor son, from the country. The Serbian King, however, benefited little from the cooperation, because he did not receive assistance from the Secret Service when he needed it most. Thus, the issue of conspiracy against his life was lightly treated throughout 1902 until his assassination in 1903. In the third and last period of cooperation, from the beginning of 1902 until the King’s assassination on 11 June 1903,1 the Russian ministries of Internal and Foreign Affairs forbade the agents to receive money from the Serbian King and relieved them of any duty regarding the protection of his life. [Projekat Ministarstva nauke Republike Srbije, br. 177014: Serbian nation: Integrating and disintegrating processes

  2. La fabrique du savoir Essai sur les carnets de voyage d'Alexander von Humboldt

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    Marie-Noëlle Bourguet

    2006-10-01

    Full Text Available Article in French, Abstract in English.Whilst the notebook belongs to the imagery of the enlightened scientist's persona (an auxiliary tool kept by his side to be hastily scribbled with data, when at the bench or in the field, it has been given little attention by historians of science, who are used to consider its manuscript pages as a documentary resource to complement the printed text, but rarely take the notebook as a material and cultural object by itself, the history and epistemology of which is to be explored. Only recently have new trends in the historiography, by historians of printed books and reading practices, and by social and cultural historians of knowledge, called for a fresh look and opened the way for new approaches. Taking Alexander von Humboldt as a paramount example, who expressly devoted his life to "observing and recording" the world, pen in hand, this paper explores the note-taking practices at work in his travel diaries and notebooks from the perspective of the history of scientific observation and cognitive practices. Four themes are successively considered : the question of method and apprenticeship ; the timing of note-taking practices ; the nature and status of the data jotted down on the page ; finally, their uses in the production of scientific knowledge. In the back and forth movement between the observation of the world and the writing of science, the notebook stood as a crucial intellectual step and cognitive tool.

  3. Nomos und physis Alexander von Humboldt und die Tradition antiker Denkweisen und Vorstellungen

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    Eberhard Knobloch

    2010-10-01

    Full Text Available Article in German.AbstractAlexander von Humboldt’s world view, philosophy of science, and scientific practice were dominated by the notions of measure and harmony. This matter of fact does not leave any doubt about Humboldt’s Pythagoreanism. Already the choice of the title of his Kosmos was led by Pythagorean thought. In 1846 he explicitly wrote to Jacobi that the whole first book is based on the idea that the first Hellenic seeds to all further progresses of mathematical natural knowledge are owed to the Pythagoreans and their emphasis on measure, number, and weight. The paper consists of four parts. The first part deals with Humboldt’s acquaintance with the fragments of the Pythagorean Philolaus. The second part compares the Aristotelean tradition with Philolaus’s informations on Pythagoreanism. The third part relying on the two foregoing parts explains Humboldt’s philosophy of science as a tranformation of Pythagoreanism. The last part discusses three examples taken from Humboldt’s scientific practice in order to illustrate the results deduced up to then.a

  4. Causes of ransom private railways in the Russian Empire during the reign of Alexander III

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    Pavel A. Gurianov

    2016-03-01

    Full Text Available This article focuses on a number of reasons, redemption of private railways in the Russian Empire during the reign of Alexander III. Preconditions for this step. After the defeat in the Crimean War, the state began to consider two basic ways construction of railways: the expense of the treasury at the expense of private capital, including foreign ones. Attempts to organize joint capital of private foreign and domestic on the example of the main Russian Railway Company ended sadly. Foreign capital is mainly interested in speculation on the Russian stock exchange, as a result the majority of the company's shares went to the Russian capital. To support the private Russian capital the government has gone the way of the guarantee capital, in certain cases, as a joint stock or bond or one of the types of capital. When distribution concessions were not crucial economic factors, and the proximity to the elite or the corruption component. Often concession won by those who offered the lowest price, which affects the quality of railway construction in the country. As a result of the concession is not got the most professionally trained people who are almost entirely the burden shifted to the state, and profits for the most part getting any private owners. As a result, such practice is ruinous for the Treasury forced the government to buy back a significant portion of private railways on acceptable terms. As a result, initially malpractice and corruption safeguards prevent a real manifestation of self-employment initiatives

  5. Alexander von Humboldt und seine geognostischen Studien in Göttingen

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    Bernd Kölbel

    2006-04-01

    Full Text Available Article in German, Abstracts in English and German.Even before he went to Freiberg (Saxony to study with Abraham Gottlob Werner, Alexander von Humboldt had done research into geognosy and the science of salt making. The results were published in the book “Mineralogische Beobachtungen über einige Basalte am Rhein”, and in „Versuch über einige physikalische und chemische Grundsätze der Salzwerkskunde“ (1792. Humboldt’s first teachers in geognosy, J. F. Blumenbach and H. F. Link had an important impact on these early studies. Until 1795, 31% of Humboldt’s scientific work consisted of research into these fields. This paper argues that, due to Humboldt’s comprehensive knowledge of the literature on geognosy, the references to this field in Steven Jan van Geuns’s journal of a common trip along the river Rhine (1789 were directly influenced by Humboldt. Thus van Geuns’s diary contains Humboldt’s first statements on volcanism, the geognosy of basalts, and references to salt making.

  6. The Development of Information Policy of the Russian Empire During the Reign of Alexander II

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    Elena S. Ustinovich

    2015-03-01

    Full Text Available During this historical period was actively carried out the process of interaction and interdependence of the development of state power and social consciousness within the limits of formation of the state information policy. Alexander II and his inner circle, given these trends and evaluating the shortcomings of the reign of his father, after years of ignoring the power of public opinion on important socio-political and socio-economic issues, after a long ban on open discussion of the shortcomings of the actions of the authorities and of the state apparatus, deliberately stimulated the beginning of the «era of conviction». Growth of social consciousness, the press has naturally gained a strong influence on representatives of the Russian society and contributed to raising awareness of and advocate for their rights. The authority is committed to the advancement of social development, directs itself to the expansion of media freedom and on the settlement of socio-political issues through dialogue, carried out with the assistance of the media.

  7. Die Bedeutung der Umkreisquellen für Alexander von Humboldts südamerikanische Reise

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    Wolfgang Griep

    2005-04-01

    Full Text Available Article in German, Abstracts in English, German and Spanish. Contrary to popular opinion, Alexander von Humboldt had little time to make in-depth preparations and acquire thorough knowledge about his most important destination, the Spanish colonies in Central and South America. So he could study most of the travelogues written by his predecessors only after returning home. Humboldt’s belated study of literary sources, combined with the question how he made use of the huge amount of facts he found during many years’ work and at the same time succeeded in being acknowledged as an outstanding researcher, are of great importance for our understanding the significance of background information in Humboldt’s work. As it seems necessary as well as promising to enquire into Humboldt’s sources in detail, this article presents within the “Humboldt Digital Library” research project a preliminary investigation of the different sources Humboldt used for describing a limited section of his South America journey: the Orinoco river system.

  8. PRAYER AND THE "SPIRITUAL CONSTITUENT" IN THE IMAGE OF A BELOVED IN ALEXANDER PUSHKIN'S LYRIC POETRY

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    Elena Alexandrovna Kuchina

    2013-11-01

    Full Text Available Prayer in Alexander Pushkin's lyric poetry appears in its natural ecclesiological context. In his prayerful poems devoted to a woman the motif of turning Love into Divinity in the light of Christian understanding of Beauty plays the most important role. Pushkin's personal prayers are very close to the patristic idea. In his poem Akathist to Ekaterina Nikolaevna Karamzina Pushkin embodied the prayer-praising; in his poem I loved you — and love it may yet be Deep in my soul... he embodied the prayer-blessing; in his sonnet Madonna the reader can find benediction and in the poem To the Beauty (1832 one can feel the state of religious reverence. The heroine of these poems is considered to be a divine creature, a sacral image. In Pushkin's lyric poetry these profound evangelical ideas are renewed. The hymnologic genre and Christian divine service in his poems become obvious. The artistic embodiment of a prayer becomes possible with the help of an iconic word and image. A prayerful word in Pushkin's poems contributes to idealization of the form that evolves from emotional and sensual state to spiritual and ascetical world-view, from the artistic and figurative word to the iconic clarity.

  9. ARCHPRIEST ALEXANDER IVANTSOV-PLATONOV: POSITIVE DIRECTION IN LITERATURE AND LIFE

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    Dmitry Andreevich Kunilsky

    2013-11-01

    Full Text Available The article examines literary and aesthetic views of a wellknown theologian and church historian Alexander Ivantsov-Platonov. The study traces crucial milestones of his scientific and creative biography which can not be always found in reference books. His work About positive and negative attitude towards life in Russian literature published in a Slavophil periodical Russkaya Beseda is the main subject of this study. The ideas stated in this article develop Slavophiles’ aesthetic programme. On the one hand, Ivantsov-Platonovs's conception of positive and negative literary directions repeats some of Konstantin Aksakovs' ideas. On the other hand, however, the church publicist develops the Slavophiles’ theory with new concepts of Russian literature. This article studies the problem of correlation between Christian values and secular art as it was seen by Ivantsov-Platonov. It also analyzes his attitude to Dostoevsky's creative works. All Ivantsov-Platonov's contemporaries describe him as a soft man, tolerant to opposite views and opinions, and always ready to help “his neighbours”. The author of the article comes to a conclusion that Ivantsov-Platonov predicted the way Russian literature would develop. The works of Tolstoy and Dostoyevsky proved that he was right in his vision.

  10. Zum Verhältnis Charles Darwins zu Alexander v. Humboldt und Christian Gottfried Ehrenberg

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    Petra Werner

    2009-05-01

    Full Text Available Article in German, Abstracts in English and German.While it is well known that Charles Darwin and Alexander von Humboldt appreciated each other's work, Humboldt's influence on Darwin has not yet been thoroughly examined. The following paper shows to what extent Darwin was inspired by Humboldt's publications while writing his Origin of Species.Darwin paid special attention to Humboldt's observations on plant migration and throughout his whole scientific career he used Humboldt's books as a major source of information. In fact, Darwin's last annotations in his copy of the Personal Narrative of travels to the Equinoctial Regions of the New continent during the Years 1799-1804 date back to the last weeks of his life.On the other hand, Darwin rejected many of Humboldt's scientific conclusions. The two authors differed in their assessment of Heinrich Bronn's biological research. Finally, Darwin was dissatisfied with Humboldtís last work Cosmos because it did not contain the information he expected. Darwinís collaboration with Humboldt's travel companion Christian Gottfried Ehrenberg proved to be similarly disappointing. Darwin sent 183 samples of infusoria to Berlin, but the results of Ehrenberg's analysis did not support Darwin's theory on evolution.

  11. Alexander von Humboldt's Idea of Interconnectedness and its Relationship to Interdisciplinarity and Communication

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    Detlev Doherr

    2015-10-01

    Full Text Available Alexander von Humboldt, a German scientist and explorer of the 19th century, viewed the natural world holistically and described the harmony of nature among the diversity of the physical world as a conjoining between all physical disciplines. He noted in his diary: "Everything is interconnectedness." The main feature of Humboldt's pioneering work was later named "Humboldtian science", meaning the accurate study of interconnected real phenomena in order to find a definite law and a dynamic cause. Following Humboldt's idea of nature, an Internet edition of his works must preserve the author's original intention, retain an awareness of all relevant works, and still adhere to the requirements of scholarly edition. At the present time, however, the highly unconventional form of his publications has undermined the awareness and a comprehensive study of Humboldt's works. Digital libraries should supply dynamic links to sources, maps, images, graphs and relevant texts. New forms of interaction and synthesis between humanistic texts and scientific observation need to be created. Information technology is the only way to do justice to the broad range of visions, descriptions and the idea of nature of Humboldt's legacy. It finally leads to virtual research environments as an adequate concept to redesign our digital archives, not only for Humboldt's documents, but for all interconnected data.

  12. BIBLICAL THEMES AND IMAGES IN ALEXANDER SOLZHENITSYN'S NOVEL "THE FIRST CIRCLE" (V KRUGE PERVOM

    Directory of Open Access Journals (Sweden)

    Svetlana Alexeyevna Martyanova

    2013-11-01

    Full Text Available The author identifies, describes and interprets the biblical allusions in Alexander Solzhenitsyn's novel The First Circle (V Kruge Pervom. It is assumed that many of the biblical characters and stories, mentioned (Moses, Jesus Christ, Holy Mary, Mother of God, or Judas or implied in the novel, are prototypical to its heroes and storylines. Biblical allusions form the overarching storyline (metaplot, and create the religious and philosophical perspective of understanding the value orientations and behavior of the characters. The article reveals the significance of the biblical context for understanding the moral and philosophical search of its heroes, their reflections on happiness, well-being, soul, conscience, friendship, creativity, truth, genuineness and authenticity of marxism as "leading-edge thinking". Special attention is given to the subject of Christmas: the article explains what it means for the formation of artistic time or images of individual characters (Volodin and Rubin, and draws a parallel betweem Stalin and Herod. It is emphasized that Solzhenitsyn as a writer did not copy reality, but portrayed it in light of the Bible and the Gospel ideal, creating the original concept of man's destiny in a totalitarian society and reintroducing to readers religious valueswhich were excluded from a human being by Soviet ideology.

  13. Alexander Scriabin: his chronic right-hand pain and Its impact on his piano compositions.

    Science.gov (United States)

    Altenmüller, Eckart

    2015-01-01

    Alexander Scriabin was an outstanding pianist and an avant-garde composer who influenced later generations with his innovative "multimedia" conceptions of aesthetic experience. As an adolescent, he was systematically trained as a concert pianist and received lessons from Vassily Safonoff, one of the founders of the legendary Russian Piano School. At age 20, Scriabin suffered an overuse injury of his right hand when attempting to improve the sound quality of his piano touch. This injury caused a deep crisis and influenced his later composition style in his piano works. From this time on, his works were frequently dominated by unusual virtuosic use and wide spans of his left hand. Rest, restricted repertoire, and an increased focus on composition contributed to recovery; however, he always remained anxious concerning the stamina of his right hand. The case report impressively demonstrates the stressors an aspiring young pianist had to cope with at the end of the nineteenth century. Furthermore, it is a convincing example of how resource-oriented behavior and intuition lead to the improvement of health status. Differential diagnoses and the modern concept of multimodal pain therapy in chronic overuse injury will be discussed from a historical perspective.

  14. Speciation despite globally overlapping distributions in Penicillium chrysogenum: the population genetics of Alexander Fleming's lucky fungus.

    Science.gov (United States)

    Henk, D A; Eagle, C E; Brown, K; Van Den Berg, M A; Dyer, P S; Peterson, S W; Fisher, M C

    2011-10-01

    Eighty years ago, Alexander Fleming described the antibiotic effects of a fungus that had contaminated his bacterial culture, kick starting the antimicrobial revolution. The fungus was later ascribed to a putatively globally distributed asexual species, Penicillium chrysogenum. Recently, the species has been shown to be genetically diverse, and possess mating-type genes. Here, phylogenetic and population genetic analyses show that this apparently ubiquitous fungus is actually composed of at least two genetically distinct species with only slight differences detected in physiology. We found each species in air and dust samples collected in and around St Mary's Hospital where Fleming worked. Genotyping of 30 markers across the genome showed that preserved fungal material from Fleming's laboratory was nearly identical to derived strains currently in culture collections and in the same distinct species as a wild progenitor strain of current penicillin producing industrial strains rather than the type species P. chrysogenum. Global samples of the two most common species were found to possess mating-type genes in a near 1:1 ratio, and show evidence of recombination with little geographic population subdivision evident. However, no hybridization was detected between the species despite an estimated time of divergence of less than 1MYA. Growth studies showed significant interspecific inhibition by P. chrysogenum of the other common species, suggesting that competition may facilitate species maintenance despite globally overlapping distributions. Results highlight under-recognized diversity even among the best-known fungal groups and the potential for speciation despite overlapping distribution.

  15. Alexander Graham Bell%亚历山大·格拉汉姆·贝尔

    Institute of Scientific and Technical Information of China (English)

    袁芳

    2012-01-01

    Alexander Graham Bell is an American inventor and Entrepreneur. He was born in Edinburgh, Scot- land on March 3rd. His father is an expert in remedying speaking and teaching the deaf. And his grandfather is a Philan- thropist, always showing sympathy to the deaf and dumb. And Bell's mother herself is a deaf and dumb. Growing up in such surroundings, he had strong will- ing to achieve in such field.%编者注 亚历山大·贝尔是一位美国发明家和企业家。他获得了世界上第一台可用的电话机的专利权(发明者为意大利人安东尼奥·梅乌奇),创建了贝尔电话公司(AT&T公司的前身)。他被世界誉为“电话之父”。

  16. Writing in learning/teaching in French (study case- freshmen “Alexander Xhuvani” University students

    Directory of Open Access Journals (Sweden)

    Leonarda Myslihaka

    2017-03-01

    Full Text Available Writing plays an important role in teaching and learning foreign languages. Students that can write in a foreign language have to verify their grammar, lexical and semantic performance and it is the role of the teacher to assess if students have learned rules correctly. This is both important for their reading and speaking skills and in general students are tested through a writing test. Writing is now an object of research and it is generally accepted that teaching/ learning cannot be performed out of the communicative acts. Students are required to produce and interpret different documents such as leaflets, journal articles etc. in a foreign language, in this case in French. The idea is that if you want to own the writing competency, you have to know very well both the lingual and contextual structure. This paper is a based on a research conducted with the first year students, studying French at the “Alexander Xhuvani” University, Elbasan, Albania, taking in consideration the lingual, psychological and social factors that affect writing. From the conclusions was clear that students had difficulties in writing due to their limited lingual competencies that leads them to orthographical mistakes etc. We also noted that students are eager to acquire this competency because learning a language through writing does not merely mean to learn syntax but it also requires a de – contextualization and creating a chance for students to get in touch with everyday language texts.

  17. Serial studies of serum dopamine-B-hydroxylase and urinary vanillylmandelic and homovanillic acids in neuroblastoma.

    Science.gov (United States)

    Brewster, M A; Berry, D H

    1979-01-01

    Recent reports have suggested that elevations of serum dopamine-B-hydroxylase (DBH) activity may correlate with diagnosis in neuroblastoma patients excreting vanillylmandelic acid (VMA). We have serially studied serum DBH and urinary homovanillic acid (HVA) and VMA excretion during the disease course of five patients with neuroblastoma. DBH activities did not indicate clinical course, therapies, or prognosis. Dilution studies revealed an age-related alteration in DBH effectors and they suggest that these may be different in neuroblastoma.

  18. Retrospective revaluation effects following serial compound training and target extinction

    NARCIS (Netherlands)

    Effting, M.; Vervliet, B.; Kindt, M.

    2010-01-01

    Using a conditioned suppression task, two experiments examined retrospective revaluation effects after serial compound training in a release from overshadowing design. In Experiment 1, serial X → A+ training produced suppression to target A, which was enhanced when preceded by feature X, whereas X b

  19. Retrospective Revaluation Effects Following Serial Compound Training and Target Extinction

    Science.gov (United States)

    Effting, Marieke; Vervliet, Bram; Kindt, Merel

    2010-01-01

    Using a conditioned suppression task, two experiments examined retrospective revaluation effects after serial compound training in a release from overshadowing design. In Experiment 1, serial X [right arrow] A+ training produced suppression to target A, which was enhanced when preceded by feature X, whereas X by itself elicited no suppression.…

  20. Serial Magnetization Transfer Imaging in Acute Optic Neuritis

    Science.gov (United States)

    Hickman, S. J.; Toosy, A. T.; Jones, S. J.; Altmann, D. R.; Miszkiel, K. A.; MacManus, D. G.; Barker, G. J.; Plant, G. T.; Thompson, A. J.; Miller, D.H.

    2004-01-01

    In serial studies of multiple sclerosis lesions, reductions in magnetization transfer ratio (MTR) are thought to be due to demyelination and axonal loss, with later rises due to remyelination. This study followed serial changes in MTR in acute optic neuritis in combination with clinical and electrophysiological measurements to determine if the MTR…

  1. Dynamics of serial position change in probe-recognition task

    Directory of Open Access Journals (Sweden)

    Fifić Mario

    2002-01-01

    Full Text Available Relationship between practice and serial position effects was investigated, in order to obtain more evidence for underlying short-term memory processes. The investigated relationship is termed the dynamics of serial position change. To address this issue, the present study investigated mean latency, errors, and performed Ex-Gaussian convolution analysis. In six-block trials the probe-recognition task was used in the so-called fast experimental procedure. The serial position effect was significant in all six blocks. Both primacy and recency effects were detected, with primacy located in the first two blocks, producing a non-linear serial position effect. Although the serial position function became linear from the third block on, the convolution analysis revealed a non-linear change of the normal distribution parameter, suggesting special status of the last two serial positions. Further, separation of convolution parameters for serial position and practice was observed, suggesting different underlying mechanisms. In order to account for these findings, a strategy shift mechanism is suggested, rather then a mechanism based on changing the manner of memory scanning. Its influence is primarily located at the very beginning of the experimental session. The pattern of results of errors regarding the dynamics of serial position change closely paralleled those on reaction times. Several models of short-term memory were evaluated in order to account for these findings.

  2. Serials Information on CD-ROM: A Reference Perspective.

    Science.gov (United States)

    Karch, Linda S.

    1990-01-01

    Describes Ulrich's PLUS (a CD-ROM version of Ulrich's serials directories) and EBSCO's CD-ROM version of "The Serials Directory," and compares the two in terms of their use as reference tools. Areas discussed include database content, user aids, system features, search features, and a comparison of search results. Equipment requirements…

  3. Serials Information on CD-ROM: A Reference Perspective.

    Science.gov (United States)

    Karch, Linda S.

    1990-01-01

    Describes Ulrich's PLUS (a CD-ROM version of Ulrich's serials directories) and EBSCO's CD-ROM version of "The Serials Directory," and compares the two in terms of their use as reference tools. Areas discussed include database content, user aids, system features, search features, and a comparison of search results. Equipment requirements for both…

  4. Are Electronic Serials Helping or Hindering Academic Libraries?

    Science.gov (United States)

    Wallenius, Leila I. T.

    2007-01-01

    As academic libraries move toward the electronic frontier for their serial subscriptions, there are several issues to be considered. This paper intends to outline the advantages and disadvantages with respect to electronic and paper serials, address selection criteria, and describe our practice in coping with these issues at the Leddy Library of…

  5. Indexing Serialized Fiction: May the Force Be with You.

    Science.gov (United States)

    Barr, Melissa M.

    The adult novel offers indexers an unusual opportunity to create a serialized fiction index. This research paper involved designing and creating a Character Index, Thesaurus, Glossary, and Abstract (with descriptors) for 21 novels based on the "Star Wars" movies. The novels are an unusual example of serialized fiction featuring main characters,…

  6. Antisocial personality disorder, sexual sadism, malignant narcissism, and serial murder.

    Science.gov (United States)

    Geberth, V J; Turco, R N

    1997-01-01

    This paper examines the research on serial murder and its relationship to antisocial personality disorder and sexual sadism. The concept of malignant narcissism is also discussed. Case studies of serial killers are examined regarding the nature of sexual violation and crime scene behavior.

  7. Implementation of Serial Port Communication System Based on SerialPort%基于SerialPort的串口通信系统实现

    Institute of Scientific and Technical Information of China (English)

    王文泉

    2011-01-01

    This article simply explains some attributes,methods,events of SerialPort based on C#,at the same time,studies and solves the key technology issues in the realization of serial port communication by use of SerialPort control.This paper designs and impleme%本文阐述了SerialPort在C#环境中作为串口通信控件的一些属性、方法和事件,并且研究解决了利用此控件实现串口通信的关键技术问题。本文设计和实现了串口通信系统的软件,实践表明:系统运行可靠,操作方便,具有一定的实际应用价值。

  8. SERIAL TELEVISI DEXTER SEBAGAI ANAKRONISME DALAM SASTRA POPULER

    Directory of Open Access Journals (Sweden)

    Ida Rochani Adi

    2014-06-01

    Full Text Available In the popular literature context, this study aims to investigate: (1 how the formulation of the characterization of Dexter in the television serial Dexter violates the tradition of literary characterization, and (2 how the formula of moral values is dramatized through Dexter, who is a sociopath, psychopath, serial killer, and person without moral. The research object was the television serial Dexter, which ranks five in popularity in the world. The data were collected by documenting 84 episodes of the serial having been broadcast since 2006. They were analyzed by means of content analysis and qualitative descriptive techniques. Based on the findings, the conclusions are as follows. First, there is a violation or anachronism of characterization through the main character in the serial. Second, the dramatized moral values still contain conventional values although they are in different forms.

  9. Design and Verification of Serial Peripheral Interface using OVM

    Directory of Open Access Journals (Sweden)

    Archana Ramesh R

    2012-11-01

    Full Text Available The main objective of the work is to design SPI Master Core using Verilog and verify the code using Open Verification Methodology. Serial Peripheral Interface (SPI is an interface that facilitates the transfer of synchronous serial data, which is engineer’s favorite for its convenience and saving system resource. SPI (Serial Peripheral Interface is a synchronous serial data link that operates in full duplex mode. It communicates in master/slave mode where the master device initiates the data frame. Multiple slave devices are allowed with individual slave select line .Serial Peripheral Interface of symmetrical structure can be synthesized using Xilinx 12.3, and then can be simulated using Questasim 10.0b. It is a popular interface used for connecting peripherals to each other and to microprocessors.

  10. Serial Entrepreneurship, Learning by Doing and Self-selection

    DEFF Research Database (Denmark)

    Rocha, Vera; Carneiro, Anabela; Varum, Celeste

    2015-01-01

    of the person-specific effect, using information on individuals’ past histories in paid employment, confirm that serial entrepreneurs exhibit, on average, a larger person-specific effect than non-serial business owners. Moreover, ignoring serial entrepreneurs’ self-selection overestimates learning by doing......It remains a question whether serial entrepreneurs typically perform better than their novice counterparts owing to learning by doing effects or mostly because they are a selected sample of higher-than-average ability entrepreneurs. This paper tries to unravel these two effects by exploring a novel...... empirical strategy based on continuous time duration models with selection. We use a large longitudinal matched employer-employee dataset that allows us to identify about 220,000 individuals who have left their first entrepreneurial experience, out of which over 35,000 became serial entrepreneurs. We...

  11. Serial CSTR digester configuration for improving biogas production from manure

    DEFF Research Database (Denmark)

    Boe, Kanokwan; Angelidaki, Irini

    2009-01-01

    A new configuration of manure digesters for improving biogas production has been investigated in laboratory scale. A single thermophilic continuous-flow stirred tank reactor (CSTR) operated with a hydraulic retention time (HRT) of 15 days was compared to a serial CSTR configuration with volume...... distribution ratio of 80/20 and 90/10, and total HRT of 15 days. The results showed that the serial CSTR could obtain 11% higher biogas yield compared to the single CSTR. The increased biogas yield in the serial CSTR was mainly from the second reactor, which accounted for 16% and 12% of total biogas yield...... in the 90/10 and 80/20 configuration, respectively. VFA concentration in the serial CSTR was high in the first reactor but very low in the second reactor. The results from organic pulse load test showed that the second reactor in serial CSTR helped utilizing VFA produced from overloading in the first...

  12. Alexander von Humboldt und Carl Friedrich Gauß als Wegbereiter der neuen Disziplin Erdmagnetismus

    Directory of Open Access Journals (Sweden)

    Karin Reich

    2011-03-01

    Full Text Available AbstractThough Alexander von Humboldt was motivated for the first time to deal with earthmagnetism during his stay in Freiberg, it was in France that he really became a specialist in this respect. During most of his journeys he made earthmagnetic measurements. His collaboration with Arago was of great importance, it was in Paris that the first magnetic observatory was built. Humboldt rendered outstanding services to the investigation of earth magnetism by two major achievements: 1. He emphasized intensity measurements and 2. he put forward the law that the magnetic intensity is increasing from the magnetic equator toward the magnetic poles. At least since 1803 Carl Friedrich Gauss was interested in earthmagnetism and especially in Humboldt’s early published data. That Wilhelm Weber became professor of physics at the University of Göttingen in 1831 was a turning point for Gauss. In 1833 Göttingen was the centre of investigating earthmagnetism, a new era began which lasted only until 1843. Gauss’ main contributions were more or less theoretical, in 1832/3 he transformed Humboldt’s relative intensity measurements into absolute ones which were independent of the instrument’s needle. A new epoch began with Gauss’ publication „Allgemeine Theorie des Erdmagnetismus” (1839. The main point was the newly defined notion of „potential“. Gauss was the first to present the surface of the earth with equipotential lines. ZusammenfassungAlexander von Humboldt hatte sich bereits in Freiberg mit dem Erdmagnetismus beschäftigt; jedoch erst in Frankreich lernte er die entsprechenden Beobachtungsmethoden kennen. Auf allen seinen Reisen machte er erdmagnetische Messungen. Seine Zusammenarbeit mit Arago in Paris war besonders fruchtbar, hier wurde das erste magnetische Observatorium gebaut. Humboldt beschäftigte sich vor allem mit Intensitätsmessungen; sein wichtigster Beitrag war die Feststellung, dass die magnetische Intensität vom

  13. Consideraciones críticas sobre el modelo de Alexander V. Chayanov

    Directory of Open Access Journals (Sweden)

    Josefina Liendo

    2013-12-01

    Full Text Available Este trabajo presenta un estado de la cuestión sobre la obra del economista ruso Alexander Chayanov y su crítica. El objetivo es analizar La organización de la unidad económica campesina [1924] desde una perspectiva que contemple tanto las intenciones del autor y la arquitectura de su obra como la crítica pasada y presente de sus lectores. Comenzando por los aspectos metodológicos, se propone revisar el modelo teórico básico y su funcionamiento real. Se entiende que el aislamiento del campesinado de su medio social más amplio es el método utilizado por el autor para construir un modelo conceptual de tipo puro. Sin embargo, su obra no se reduce a este objetivo. Al tratarse de una teoría práctica, Chayanov busca probar el funcionamiento real del modelo dejando caer los supuestos iniciales para insertar a los campesinos en el marco más amplio de la economía de mercado, introduciendo elementos ausentes en la simplificación inicial: la situación de mercado, los salarios y las inversiones de capital. El análisis conduce a sostener que la operación metodológica que el autor realiza para construir la teoría socava su capacidad explicativa. Se reflexiona, finalmente, sobre las virtudes y limitaciones de la obra desde una perspectiva histórica

  14. Death by polonium-210: lessons learned from the murder of former Soviet spy Alexander Litvinenko.

    Science.gov (United States)

    McFee, Robin B; Leikin, Jerrold B

    2009-02-01

    The medical response to radiation--whether the result of radiological warfare, terrorist deployment of improvised radiation dispersal weapons, political assassination, occupational or industrial accidents or the medically radiated patient remains one of the least taught among all disciplines within medical education. In the aftermath of 9/11 among medical vulnerabilities to toxicant threats, of all the categories of weapons of mass destruction (WMD)--whether using the CBRNE (chemical, biological, radiological, nuclear, explosive) or NBC (nuclear, biological, chemical) acronym--radiation is the least taught in professional schools, responder cultures or civil preparedness organizations. To date, few health care professionals (HCP) possess the fundamental knowledge or skills to identify and diagnose, let alone treat a radiation victim; this vulnerability made even more obvious in the aftermath of the high profile assassination of former Russian agent Alexander Litvinenko. He was poisoned with Polonium210. Radioactive substances are ubiquitous with radiation sources being in or transported through virtually every region nationwide. It is essential to increase preparedness among community and rural health care facilities as well as urban and university hospitals. Managing radiation injuries effectively requires access to specialized equipment and expertise. Radiation sickness is progressive and may require acute, critical and long-term care throughout the course of illness. Regardless of the source, preparedness rests upon acknowledging a threat exists and dedicating the resources to address the risks including the enhancement of training and equipment. Mass or individual exposures to radiation present unique challenges to the entire response continuum from law enforcement, first responders and emergency medical care. Increased education about and practice in responding to radiological threats is essential to enhance preparedness.

  15. Project Alexander the Great: a study on the world proliferation of bioengineering/biomedical engineering education.

    Science.gov (United States)

    Abu-Faraj, Ziad O

    2008-01-01

    Bioengineering/Biomedical Engineering is considered amongst the most reputable fields within the global arena, and will likely be the primer for any future breakthroughs in Medicine and Biology. Bioengineering/biomedical engineering education has evolved since late 1950s and is undergoing advancement in leading academic institutions worldwide. This paper delineates an original study on the world proliferation of bioengineering/biomedical engineering education and bears the name 'Project Alexander the Great'. The initial step of the project was to survey all 10448 universities, recognized by the International Association of Universities, spread among the 193 member states of the United Nations within the six continents. The project aims at identifying, disseminating, and networking, through the world-wide-web, those institutions of higher learning that provide bioengineering/biomedical engineering education. The significance of this project is multifold: i) the inception of a web-based 'world-map' in bioengineering/biomedical engineering education for the potential international student desiring to pursue a career in this field; ii) the global networking of bioengineering/biomedical engineering academic/research programs; iii) the promotion of first-class bioengineering/biomedical engineering education and the catalysis of global proliferation of this field; iv) the erection of bridges among educational institutions, industry, and professional societies or organizations involved in Bioengineering/Biomedical Engineering; and v) the catalysis in the establishment of framework agreements for cooperation among the identified institutions offering curricula in this field. This paper presents the results obtained from Africa and North America. The whole project is due to be completed by 2009.

  16. The Impact of International Standardization on the Rules of Entry for Serials

    Science.gov (United States)

    Cannan, Judith Proctor

    1975-01-01

    The major provisions of the International Serials Data System and International Standard Bibliographic Description for Serials are presented and related to present rules of entry for serials as detailed in the Anglo-American Cataloging Rules. (Author)

  17. Task based synthesis of serial manipulators

    Directory of Open Access Journals (Sweden)

    Sarosh Patel

    2015-05-01

    Full Text Available Computing the optimal geometric structure of manipulators is one of the most intricate problems in contemporary robot kinematics. Robotic manipulators are designed and built to perform certain predetermined tasks. There is a very close relationship between the structure of the manipulator and its kinematic performance. It is therefore important to incorporate such task requirements during the design and synthesis of the robotic manipulators. Such task requirements and performance constraints can be specified in terms of the required end-effector positions, orientations and velocities along the task trajectory. In this work, we present a comprehensive method to develop the optimal geometric structure (DH parameters of a non-redundant six degree of freedom serial manipulator from task descriptions. In this work we define, develop and test a methodology to design optimal manipulator configurations based on task descriptions. This methodology is devised to investigate all possible manipulator configurations that can satisfy the task performance requirements under imposed joint constraints. Out of all the possible structures, the structures that can reach all the task points with the required orientations are selected. Next, these candidate structures are tested to see whether they can attain end-effector velocities in arbitrary directions within the user defined joint constraints, so that they can deliver the best kinematic performance. Additionally least power consuming configurations are also identified.

  18. Serial femtosecond crystallography: the first five years

    Directory of Open Access Journals (Sweden)

    Ilme Schlichting

    2015-03-01

    Full Text Available Protein crystallography using synchrotron radiation sources has had a tremendous impact on biology, having yielded the structures of thousands of proteins and given detailed insight into their mechanisms. However, the technique is limited by the requirement for macroscopic crystals, which can be difficult to obtain, as well as by the often severe radiation damage caused in diffraction experiments, in particular when using tiny crystals. To slow radiation damage, data collection is typically performed at cryogenic temperatures. With the advent of free-electron lasers (FELs capable of delivering extremely intense femtosecond X-ray pulses, this situation appears to be remedied, allowing the structure determination of undamaged macromolecules using either macroscopic or microscopic crystals. The latter are exposed to the FEL beam in random orientations and their diffraction data are collected at cryogenic or room temperature in a serial fashion, since each crystal is destroyed upon a single exposure. The new approaches required for crystal growth and delivery, and for diffraction data analysis, including de novo phasing, are reviewed. The opportunities and challenges of SFX are described, including applications such as time-resolved measurements and the analysis of radiation damage-prone systems.

  19. Serial fetal blood sampling for the management of pregnancies complicated by severe rhesus (D) isoimmunization.

    Science.gov (United States)

    MacKenzie, I Z; Bowell, P J; Castle, B M; Selinger, M; Ferguson, J F

    1988-08-01

    Fifty-one pregnancies complicated by rhesus (D) isoimmunization have been managed by serial fetal blood sampling between 17 and 36 weeks gestation as an alternative to amniocentesis for delta OD453 measurements. In 36 pregnancies where the fetus was shown to be rhesus (D) positive and both measurements were made before any intrauterine fetal transfusions, the delta OD453 value gave misleading predictions on 13 of 63 occasions (21%). Fetal haematocrit estimations provided a direct assessment of the haemopoietic compensation occurring, but fetal bilirubin and albumin concentrations did not correlate directly with disease severity. It is proposed that pregnancies complicated by severe isoimmunization can be more precisely managed by serial fetal blood sampling for haematocrit estimation than amniocentesis for delta OD453 measurement thus avoiding unnecessary intervention or delayed treatment.

  20. Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis.

    Directory of Open Access Journals (Sweden)

    Andrew S Krueger

    Full Text Available Flux balance analysis (FBA is an increasingly useful approach for modeling the behavior of metabolic systems. However, standard FBA modeling of genetic knockouts cannot predict drug combination synergies observed between serial metabolic targets, even though such synergies give rise to some of the most widely used antibiotic treatments. Here we extend FBA modeling to simulate responses to chemical inhibitors at varying concentrations, by diverting enzymatic flux to a waste reaction. This flux diversion yields very similar qualitative predictions to prior methods for single target activity. However, we find very different predictions for combinations, where flux diversion, which mimics the kinetics of competitive metabolic inhibitors, can explain serial target synergies between metabolic enzyme inhibitors that we confirmed in Escherichia coli cultures. FBA flux diversion opens the possibility for more accurate genome-scale predictions of drug synergies, which can be used to suggest treatments for infections and other diseases.

  1. Serial forced displacement in American cities, 1916-2010.

    Science.gov (United States)

    Fullilove, Mindy Thompson; Wallace, Rodrick

    2011-06-01

    Serial forced displacement has been defined as the repetitive, coercive upheaval of groups. In this essay, we examine the history of serial forced displacement in American cities due to federal, state, and local government policies. We propose that serial forced displacement sets up a dynamic process that includes an increase in interpersonal and structural violence, an inability to react in a timely fashion to patterns of threat or opportunity, and a cycle of fragmentation as a result of the first two. We present the history of the policies as they affected one urban neighborhood, Pittsburgh's Hill District. We conclude by examining ways in which this problematic process might be addressed.

  2. A new serial number marking system applicable to firearms identification.

    Science.gov (United States)

    Polk, D E; Giessen, B C

    1975-07-01

    A new system for physically recording serial numbers on individual items is proposed. Each serial number is converted to a unique array of points, and this array is recorded on the item by drilling a set of holes having the arrangement of the array into the item. Laser drilling can be used to produce holes of small diameter for the array. The identifying marks extend into the item and cannot be readily removed as surface stampings. In some cases the serial number can be marked in a critical area, so that its removal would destroy the usefulness of the item. This system is particularly suitable for the marking of firearms.

  3. Serials cataloging at the turn of the century

    CERN Document Server

    Williams, James W

    2014-01-01

    An overview of the research topics and trends that have appeared over the last five years, Serials Cataloging at the Turn of the Century doesn't just tell you that there has been a lot of change--that the information environment is something of a chameleon, always beguiling and slipping out of grasp. Instead, it gives you the plain facts on the specific challenges serials catalogers have been facing and how they're meeting adversity head-on, ready to gain the advantage in the rumble with proliferating information and formats.Comprehensive, resource-packed, and easy-to-digest, Serials Catalogin

  4. Transtornos de personalidade, psicopatia e serial killers Personality disorders, psychopathy and serial killers

    Directory of Open Access Journals (Sweden)

    Hilda C P Morana

    2006-10-01

    Full Text Available OBJETIVO: Apresentar as características básicas dos diversos transtornos específicos de personalidade, mas centrando-se no transtorno de personalidade anti-social, fazendo sua diferenciação com psicopatia. O estudo ainda se propõe a abordar a figura do serial killer, apontando a presença de aspectos psicopáticos no homicídio seriado. MÉTODO: Uma revisão bibliográfica foi feita no sentido de se abordar convergências e divergências entre diversos autores sobre um assunto tão polêmico, sobretudo quanto à viabilidade de tratamento dessa clientela forense. RESULTADOS: Enquanto o transtorno de personalidade anti-social é um diagnóstico médico, pode-se entender o termo "psicopatia", pertencente à esfera psiquiátrico-forense, como um "diagnóstico legal". Não se pode falar ainda de tratamento eficaz para os chamados "serial killers". CONCLUSÃO: Os transtornos de personalidade, especialmente o tipo anti-social, representam ainda hoje um verdadeiro desafio para a psiquiatria forense. O local mais adequado e justo para seus portadores, bem como recomendação homogênea e padronizada de tratamento são questões ainda não respondidas.OBJECTIVE: To illustrate the basic characteristics of several specific personality disorders, focusing mainly in antisocial personality disorder. The differences between antisocial personality disorder and psychopathy are highlighted. Serial killers and its psychopathic aspects are also discussed. METHOD: A bibliographic review was completed in order to outline convergences and divergences among different authors about this controversial issue, especially those concerning the possibility of treatment. RESULTS: While anti-social personality disorder is a medical diagnosis, the term "psychopathy" (which belongs to the sphere of forensic psychiatry may be understood as a "legal diagnosis". It is not still possible to identify an effective treatment for serial killers. CONCLUSION: Personality disorders

  5. Area Efficient and A High Bit Rate Serial-Serial Multiplier With On-the-Fly Accumulation by Asynchronous Counters

    Directory of Open Access Journals (Sweden)

    Balakrishna Konda

    2012-11-01

    Full Text Available Traditional Serial-Serial multiplier addresses the high data sampling rate. It is effectively considered as the entire partial product matrix with n data sampling cycle for n×n multiplication function instead of 2n cycles in the conventional multipliers. This multiplication of partial products by considering two series inputs among which one is starting from LSB the other from MSB. Using this feed sequence and accumulation technique it takes only n cycle to complete the partial products. It achieves high bit sampling rate by replacing conventional full adder and highest 5:3 counters. Here asynchronous 1’s counter is presented. This counter takes critical path is limited to only an AND gate and D flip-flops. Accumulation is integral part of serial multiplier design. 1’s counter is used to count the number of ones at the end of the nth iteration in each counter produces. The implemented multipliers consist of a serial-serial data accumulator module and carry save adder that occupies less silicon area than the full carry save adder. In this paper we implemented model address for the 8bit 2’s complement implementing the Baugh-wooley algorithm and unsigned multiplication implementing the architecture for 8×8 Serial-Serial unsigned multiplication.

  6. Automatic registration of serial mammary gland sections

    Energy Technology Data Exchange (ETDEWEB)

    Arganda-Carreras, Ignacio; Fernandez-Gonzalez, Rodrigo; Ortiz-de-Solorzano, Carlos

    2004-04-13

    We present two new methods for automatic registration of microscope images of consecutive tissue sections. They represent two possibilities for the first step in the 3-D reconstruction of histological structures from serially sectioned tissue blocks. The goal is to accurately align the sections in order to place every relevant shape contained in each image in front of its corresponding shape in the following section before detecting the structures of interest and rendering them in 3D. This is accomplished by finding the best rigid body transformation (translation and rotation) of the image being registered by maximizing a matching function based on the image content correlation. The first method makes use of the entire image information, whereas the second one uses only the information located at specific sites, as determined by the segmentation of the most relevant tissue structures. To reduce computing time, we use a multiresolution pyramidal approach that reaches the best registration transformation in increasing resolution steps. In each step, a subsampled version of the images is used. Both methods rely on a binary image which is a thresholded version of the Sobel gradients of the image (first method) or a set of boundaries manually or automatically obtained that define important histological structures of the sections. Then distance-transform of the binary image is computed. A proximity function is then calculated between the distance image of the image being registered and that of the reference image. The transformation providing a maximum of the proximity function is then used as the starting point of the following step. This is iterated until the registration error lies below a minimum value.

  7. Alexander von Humboldt” als Name für Forschungsschiffe vor dem Hintergrund seiner meereskundlichen Arbeiten

    Directory of Open Access Journals (Sweden)

    Gerhard Kortum

    2002-10-01

    Full Text Available Article in German, Abstract in English. A. v. Humboldt as a Name of Research VesselsA number of special purpose vessels in the world carried or carry the name of Alexander von Humboldt, who had substantial interests in oceanography. However, most of his marine texts are scattered over his major works, and he never finished his manuscript on ocean circulation. But there is a general agreement that A. v. Humboldt was one of the pioneers of marine sciences. He made his own observations on the sailing vessels he used on his expedition to the Neotropics, mainly concerning sea surface temperatures. In 2002 there was a discussion in Germany about the name of a new research vessel which is going to be commissioned in the summer of 2004. It was suggested by the science community to take the name of „Alexander von Humboldt“ again, as the new vessel is replacing a medium-sized ship with this name operated now by the Baltic Sea Research Institute in Rostock-Warnemünde. This vessel has been in service from 1970 to 1990 for the Academy of Sciences of the former German Democratic Republic. The first German research vessel „Alexander von Humboldt“ was a fishing trawler (1939. Furthermore, Peru and Mexico operate research vessels bearing Humboldt’s name. The best known „Alexander von Humboldt“ is an ocean going sailing ship of the International Sail Training Association, based in Bremen. She is engaged in educational programmes and went the South America in 1999 following Humboldt’s route. Thus, Humboldt’s marine legacy is preserved. The proposal to use the undisputed name of this great all-round scientist for the new German vessel under construction now was not successful. A high-ranking jury decided to prefer “Maria Sibylla Merian” (1647-1717, which was suggested by a young student in a nation-wide competition to find a name. As Humboldt 100 years later, she went to South America to study plants and other fields of natural history.

  8. The Grothendieck festschrift a collection of articles written in honor of the 60th birthday of Alexander Grothendieck

    CERN Document Server

    Cartier, Pierre; Katz, Nicholas; Manin, Yuri; Illusie, Luc; Laumon, Gérard; Ribet, Kenneth

    2009-01-01

    This three-volume work contains articles collected on the occasion of Alexander Grothendieck's sixtieth birthday and originally published in 1990. The articles were offered as a tribute to one of the world's greatest living mathematicians. Many of the groundbreaking contributions in these volumes contain material that is now considered foundational to the subject. Topics addressed by these top-notch contributors match the breadth of Grothendieck's own interests, including: functional analysis, algebraic geometry, algebraic topology, number theory, representation theory, K-theory, category theo

  9. Effect of serial extraction alone on crowding: spontaneous changes in dentition after serial extraction.

    Science.gov (United States)

    Yoshihara, T; Matsumoto, Y; Suzuki, J; Sato, N; Oguchi, H

    2000-12-01

    We examined changes in dentition after serial extraction in subjects who wore no appliances to determine the relationships between changes in dentition and improvement in dental crowding. Mandibular dental casts and lateral cephalograms from 31 subjects who had undergone serial extraction without orthodontic treatment were analyzed at 3 stages: before extraction of the deciduous canines (T1), after extraction of first premolars (T2), and at the end of the observation period (T3). Although movements of the first molar cusp and apex from T2 to T3 were significantly greater than from T1 to T2, movements of the incisor cusp and apex from T1 to T2 were significantly greater than from T2 to T3. The first molar tipped mesially from T1 to T2 but tipped distally from T2 to T3. The distal tipping of the incisor from T1 to T2 was significantly greater than from T2 to T3. These results suggest that the main changes in dentition from T1 to T2 are different from those from T2 to T3. The correlations between the annual change in the canine movement or tipping from T2 to T3 and the annual change in the irregularity index at the same time were significant. These results suggest that the canine movement or tipping contributed to the correction of the anterior crowding from T2 to T3.

  10. Fast Grasp Contact Computation for a Serial Robot

    Science.gov (United States)

    Shi, Jianying (Inventor); Hargrave, Brian (Inventor); Diftler, Myron A. (Inventor)

    2015-01-01

    A system includes a controller and a serial robot having links that are interconnected by a joint, wherein the robot can grasp a three-dimensional (3D) object in response to a commanded grasp pose. The controller receives input information, including the commanded grasp pose, a first set of information describing the kinematics of the robot, and a second set of information describing the position of the object to be grasped. The controller also calculates, in a two-dimensional (2D) plane, a set of contact points between the serial robot and a surface of the 3D object needed for the serial robot to achieve the commanded grasp pose. A required joint angle is then calculated in the 2D plane between the pair of links using the set of contact points. A control action is then executed with respect to the motion of the serial robot using the required joint angle.

  11. Connecting the New World. Nets, mobility and progress in the Age of Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Moritz von Brescius

    2012-12-01

    Full Text Available Zusammenfassung Dieser Artikel untersucht das Verhältnis zwischen den revolutionären technologischen Neuerungen des 19. Jahrhunderts und dem Leben und Wirken Alexander von Humboldts (1769-1859. Dabei wird gefragt, wie Humboldt versuchte, die neuen und sprichwörtlich bahnbrechenden Kommunikations- und Transporttechnologien seiner Zeit zu nutzen, um den amerikanischen Kontinent in globale kommerzielle und kulturelle Austauschprozesse zu integrieren. Jüngere Forschungen zu Humboldts amerikanischer Expedition (1799-1804 haben behauptet, dass seine Beschreibungen Südamerikas den Kontinent für zahlreiche „transformative interventions“ (Pratt von Seiten europäischer Kapitalisten und Investoren zugänglich gemacht hätten. Diese Studien haben jedoch nicht analysiert, aus welchen Motiven heraus Humboldt diese Eingriffe in die Natur unterstützte. Darüber hinaus wurde nicht der zentralen Frage nachgegangen, welche Rolle diese Projekte in Humboldts eigener Auffassung über die Kräfte des gesellschaftlichen Fortschritts gespielt haben. Um Humboldts Unterstützung für tiefgreifende Eingriffe in die Natur Amerikas nachvollziehen zu können, analysiert dieser Artikel zunächst, welche Rolle der „Geodeterminismus“ und die Fortschrittstheorien der Aufklärung in seinem Verständnis von zivilisatorischer Entwicklung spielten. Dabei sollen solche Beispiele menschlicher Interventionen in die Natur Amerikas untersucht werden, die Humboldt selbst aktiv förderte – nicht zuletzt, da sie geeignet schienen, „natürliche“ Barrieren für gesellschaftliche Austauschprozesse zu beseitigen. Dies waren vor allem die Nutzung von Dampfschiffen, elektrischer Telegrafie, Eisenbahnen und großangelegten Kanalprojekten, deren gebündelte Effekte zu einer signifikanten Beschleunigung von Welthandel und Kommunikationsprozessen führten. Diese zeitgenössischen Innovationen sollen mit den vier Motiven „Netz“, „Mobilität“, „Fortschritt“ und

  12. Huntington's disease

    DEFF Research Database (Denmark)

    Hjermind, Lena Elisabeth; Law, Ian; Jønch, Aia

    2011-01-01

    In this open-label pilot study, the authors evaluated the effect of memantine on the distribution of brain glucose metabolism in four Huntington's disease (HD) patients as determined by serial 18-fluoro-deoxyglucose [F(18)]FDG-PET scans over a period of 3-4 months (90-129 days, with one patient...

  13. Alexander Mikhailovich Zakharov and his works on the venom apparatus and venoms of some poisonous snakes

    Directory of Open Access Journals (Sweden)

    Cherlin Vladimir Alexandrovich

    2013-10-01

    Full Text Available The article gives brief biographical information about a very talented herpetologist Alexander M. Zakharov, and describes the general results of his works on the structure and function of venom glands of some poisonous snakes and their venoms. In his studies, he got the results, which are fundamentally different from the conventional concept of 30s - 70s of the XX century. Unfortunately, among physicians this concept has not changed up today. At that time it was thought that the poisons of Viperidae snakes are almost completely hemotoxic, and poisons of Elapidae (cobra are almost neurotoxic. But A.M.Zaharov found out, that poisons of both types of snakes (Viperidae and Elapidae include three groups of substances: hemotoxins, neurotoxins and non-toxic component – hyaluronidase. Each of these groups of substances is produced by independent part of venom glands and has its own special effect. Neurotoxins act on the central nervous system (mainly the respiratory center, but are greatly destroyed by means of the blood antigen properties and cannot pass through the hematoencephalic barrier. Hyaluronidase , connecting with neurotoxins, has an important property – to "smuggle" neurotoxins through the hematoencephalic barrier exactly into the target organ – the respiratory center in the central nervous system. In this case, neurotoxin enters the respiratory center not through the blood and lymph vessels, but directly through the nerve channel, through synapsis. The main function of hemotoxins is not to kill the victim, but to protect neurotoxins and hyaluronidase from the destructive activity of the victim's blood. Therefore, the target of the poisons of Viperidae and Elapidae snakes is the central nervous system of victims, but Elapidae has almost no hemotoxins. That’s why their striking effect can be achieved only by a strong increase in the amount of neurotoxins and hyaluronidase. Hemotoxins of Viperidae venoms permits to reduce the amount of

  14. [A serial killer as exemplified by T. R. Bundy].

    Science.gov (United States)

    Gałeska-Sliwka, Anita

    2008-01-01

    The question of serial homicides and their perpetrators poses a considerable problem of both a definitional and practical nature. T R. Bundy is the first perpetrator who was officially termed a "serial killer". Since that time, this concept has been commonly used and sometimes even overused, e.g. in reference to mass murderers. However, the definitions established for Bundy's case have been preserved and continue to be used in practice.

  15. Serial Communications Programming in Windows95 with API Functions

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper introduces the usage of these functions. It presents the technique of how to program with them to perform the serial communications between a computer and other digital devices by the serial ports in Windows95.The related sample codes of the applications of this technique written in C++ programming language are also given. This technique is applied successfully to receive the data of the radio noise from a frequency monitor.

  16. How Do We Write about Performance in Serial Television?

    OpenAIRE

    2015-01-01

    Television studies has produced few sustained analyses of performance in serial television. Yet film studies scholarship has shown how attending to the integration of performances with other aspects of film style is crucial to the interpretation and appreciation of expression and meaning in filmed narrative fictions. However, as a particle form of filmed serial narrative, series television raises a number of questions about performance that will not necessarily be satisfyingly addressed by th...

  17. Serial extraction: 20 years of follow-up

    OpenAIRE

    Renato Rodrigues de Almeida; Marcio Rodrigues de Almeida; Paula Vanessa Pedron Oltramari-Navarro; Ana Cláudia de Castro Ferreira Conti; Ricardo de Lima Navarro; Karen Regina Siqueira de Souza

    2012-01-01

    This paper reports a case treated by a serial extraction program at the mixed dentition stage followed by a corrective orthodontic treatment, with a long-term follow-up period. Twenty years after the interceptive treatment, a harmonious face was observed along with treatment stability in the anterior posterior direction, deep overbite (which has been mentioned as a disadvantage of the serial extraction program), and a small relapse of anterior tooth crowding. All these conditions have been re...

  18. How Do We Write about Performance in Serial Television?

    Directory of Open Access Journals (Sweden)

    Elliott Logan

    2015-05-01

    Full Text Available Television studies has produced few sustained analyses of performance in serial television. Yet film studies scholarship has shown how attending to the integration of performances with other aspects of film style is crucial to the interpretation and appreciation of expression and meaning in filmed narrative fictions. However, as a particle form of filmed serial narrative, series television raises a number of questions about performance that will not necessarily be satisfyingly addressed by the direct adoption and application of approaches to writing about performance that have been honed in regard to film. How, then, do we write about performance in television serials in ways that recognise and accommodate the form’s relationship to film, while at the same time appropriately acknowledging and responding to long-form television’s serial status? To examine the difficulties and opportunities of approaching performance in serial television this way, the article conducts close readings of various pieces of television studies writing on performance, by scholars such as Jason Mittell, Sue Turnbull, George Toles, and Steven Peacock. Their work brings into view film and television’s points of common relation, and the distinctive challenges, achievements, and rewards of appreciating the best television serials, and the performances in them.

  19. Serial CSTR digester configuration for improving biogas production from manure.

    Science.gov (United States)

    Boe, Kanokwan; Angelidaki, Irini

    2009-01-01

    A new configuration of manure digesters for improving biogas production has been investigated in laboratory scale. A single thermophilic continuous-flow stirred tank reactor (CSTR) operated with a hydraulic retention time (HRT) of 15 days was compared to a serial CSTR configuration with volume distribution ratio of 80/20 and 90/10, and total HRT of 15 days. The results showed that the serial CSTR could obtain 11% higher biogas yield compared to the single CSTR. The increased biogas yield in the serial CSTR was mainly from the second reactor, which accounted for 16% and 12% of total biogas yield in the 90/10 and 80/20 configuration, respectively. VFA concentration in the serial CSTR was high in the first reactor but very low in the second reactor. The results from organic pulse load test showed that the second reactor in serial CSTR helped utilizing VFA produced from overloading in the first reactor, which improved the effluent quality and conversion efficiency of the serial CSTR.

  20. Three more semantic serial position functions and a SIMPLE explanation.

    Science.gov (United States)

    Kelley, Matthew R; Neath, Ian; Surprenant, Aimée M

    2013-05-01

    There are innumerable demonstrations of serial position functions-with characteristic primacy and recency effects-in episodic tasks, but there are only a handful of such demonstrations in semantic memory tasks, and those demonstrations have used only two types of stimuli. Here, we provide three more examples of serial position functions when recalling from semantic memory. Participants were asked to reconstruct the order of (1) two cartoon theme song lyrics, (2) the seven Harry Potter books, and (3) two sets of movies, and all three demonstrations yielded conventional-looking serial position functions with primacy and recency effects. The data were well-fit by SIMPLE, a local distinctiveness model of memory that was originally designed to account for serial position effects in short- and long-term episodic memory. According to SIMPLE, serial position functions in both episodic and semantic memory tasks arise from the same type of processing: Items that are more separated from their close neighbors in psychological space at the time of recall will be better remembered. We argue that currently available evidence suggests that serial position functions observed when recalling items that are presumably in semantic memory arise because of the same processes as those observed when recalling items that are presumably in episodic memory.

  1. “It’s Always the Same, and It’s Always Different” Mythologisation and the Serial Killer in Henry: Portrait of a Serial Killer.

    OpenAIRE

    Smyth, David A.

    2015-01-01

    Serial killers are important in American horror because of their ability to exist between ‘myth’ and ‘reality’. The serial killer is one of the most important American myths, but it is one firmly rooted in real life: unlike Paul Bunyan or Superman, serial killers do exist. This essay examines the relationship between the ‘myth’ and the ‘reality’ of serial killers, and the complex relationship between the American public and the serial killer, using Henry: Portrait of a Serial K...

  2. Eine Freundschaft, die Jahrzehnte überdauerte! Ein unveröffentlichter Brief Alexander von Humboldts an seinen langjährigen Freund Johann Karl Freiesleben

    Directory of Open Access Journals (Sweden)

    Katja Mönnich

    2013-04-01

    Full Text Available Zusammenfassung Der vorliegende Brief Alexander von Humboldts an seinen Jugendfreund Johann Karl Freiesleben (1774-1846 reiht sich ein in das Vorhaben, unpublizierte Briefe aus Humboldts Jugendzeit der Öffentlichkeit zugänglich zu machen. Editorisch fügt sich der Brief in die von Ilse Jahn und Fritz Gustav Lange herausgegebenen Jugendbriefe Alexander von Humboldts 1787-1799 ein. In diesem Band findet der Brief seinen Platz zwischen zwei Briefen Humboldts an Freiesleben, die er während seines Aufenthaltes in Dresden am 10.07.1797 sowie am 11. oder 18.07.1797 geschrieben hat. Resumen La carta de Alexander von Humboldt a su amigo de juventud Johann Karl Freiesleben (1774-1846 es parte del proyecto de investigación, que presenta cartas del joven Humboldt todavía no publicadas. Editorialmente, la carta fue adaptada a la publicación de la edición Jugendbriefe Alexander von Humboldts 1787-1799, presentada por Ilse Jahn y Fritz Gustav Lange. En este volumen, la carta está ubicada entre dos cartas de Humboldt a Freiesleben, que escribió en Dresde el 10 de julio y el 11 o 18 de julio 1797. Abstract The letter of Alexander von Humboldt to his childhood friend Johann Karl Freiesleben (1774-1846 is part of the project of making unpublished letters from Humboldt’s youth accessible to the public. Editorially, the letter fits in the edition Jugendbriefe Alexander von Humboldts 1787-1799, published by Ilse Jahn and Fritz Gustav Lange. In this volume, the letter is placed between two letters from Humboldt to Freiesleben, which he wrote during his stay in Dresden on 10th of July and on 11th or 18th of July 1797.

  3. „Vater einer großen Nachkommenschaft von Forschungsreisenden ...“ Ehrungen Alexander von Humboldts im Jahre 1869

    Directory of Open Access Journals (Sweden)

    Ilse Jahn

    2004-04-01

    Full Text Available Article in German, Abstracts in English and GermanIn 1869 the “Naturwissenschaftlicher Verein” was founded in Magdeburg (Saxony Anhalt. That was the time when the scientific world celebrated Alexander von Humboldt’s 100th birthday. In this context, Humboldt’s achievements were remembered during the founding ceremony of that society. The paper which was read in September 2003 on a meeting of this organisation, focuses on three famous naturalists who celebrated Humboldt because they owed him much help in their own professional careers. The botanist Matthias Jacob Schleiden gave a memorial speech in 1869 in Dresden. The physiologist and pioneer of electro-biology Emil du Bois-Reymond honoured his mentor A. v. Humboldt on the occasion of the dedication of the statues of Wilhelm and Alexander in 1883 in Berlin. Charles Darwin expressed his gratitude to Humboldt by sending him in 1839 the report of his travels and received an interesting reply. These three scholars represented a new epoch in the development of the natural sciences. The paper includes a recently re-discovered letter from Humboldt to Schleiden, dated April 13, 1842.

  4. The predictive diagnostic value of serial daily bedside ultrasonography for severe dengue in Indonesian adults.

    Directory of Open Access Journals (Sweden)

    Meta Michels

    Full Text Available BACKGROUND: Identification of dengue patients at risk for progressing to severe disease is difficult. Significant plasma leakage is a hallmark of severe dengue infection which can suddenly lead to hypovolemic shock around the time of defervescence. We hypothesized that the detection of subclinical plasma leakage may identify those at risk for severe dengue. The aim of the study was to determine the predictive diagnostic value of serial ultrasonography for severe dengue. METHODOLOGY/PRINCIPAL FINDINGS: Daily bedside ultrasounds were performed with a handheld ultrasound device in a prospective cohort of adult Indonesians with dengue. Timing, localization and relation to dengue severity of the ultrasonography findings were determined, as well as the relation with serial hematocrit and albumin values. The severity of dengue was retrospectively determined by WHO 2009 criteria. A total of 66 patients with proven dengue infection were included in the study of whom 11 developed severe dengue. Presence of subclinical plasma leakage at enrollment had a positive predictive value of 35% and a negative predictive value of 90% for severe dengue. At enrollment, 55% of severe dengue cases already had subclinical plasma leakage, which increased to 91% during the subsequent days. Gallbladder wall edema was more pronounced in severe than in non-severe dengue patients and often preceded ascites/pleural effusion. Serial hematocrit and albumin measurements failed to identify plasma leakage and patients at risk for severe dengue. CONCLUSIONS/SIGNIFICANCE: Serial ultrasonography, in contrast to existing markers such as hematocrit, may better identify patients at risk for development of severe dengue. Patients with evidence of subclinical plasma leakage and/or an edematous gallbladder wall by ultrasonography merit intensive monitoring for development of complications.

  5. The metallogeny of Late Triassic rifting of the Alexander terrane in southeastern Alaska and northwestern British Columbia

    Science.gov (United States)

    Taylor, C.D.; Premo, W.R.; Meier, A.L.; Taggart, J.E.

    2008-01-01

    A belt of unusual volcanogenic massive sulfide (VMS) occurrences is located along the eastern margin of the Alexander terrane throughout southeastern Alaska and northwestern British Columbia and exhibits a range of characteristics consistent with a variety of syngenetic to epigenetic deposit types. Deposits within this belt include Greens Creek and Windy Craggy, the economically most significant VMS deposit in Alaska and the largest in North America, respectively. The occurrences are hosted by a discontinuously exposed, 800-km-long belt of rocks that consist of a 200- to 800-m-thick sequence of conglomerate, limestone, marine elastic sedimentary rocks, and tuff intercalated with and overlain by a distinctive unit of mafic pyroclastic rocks and pillowed flows. Faunal data bracket the age of the host rocks between Anisian (Middle Triassic) and late Norian (late Late Triassic). This metallogenic belt is herein referred to as the Alexander Triassic metallogenic belt. The VMS occurrences show systematic differences in degree of structural control, chemistry, and stratigraphic setting along the Alexander Triassic metallogenic belt that suggest important spatial or temporal changes in the tectonic environment of formation. At the southern end of the belt, felsic volcanic rocks overlain by shallow-water limestones characterize the lower part of the sequence. In the southern and middle portion of the belt, a distinctive pebble conglomerate marks the base of the section and is indicative of high-energy deposition in a near slope or basin margin setting. At the northern end of the belt the conglomerates, limestones, and felsic volcanic rocks are absent and the belt is composed of deep-water sedimentary and mafic volcanic rocks. This northward change in depositional environment and lithofacies is accompanied by a northward transition from epithermal-like structurally controlled, discontinuous, vein- and pod-shaped, Pb-Zn-Ag-Ba-(Cu) occurrences with relatively simple mineralogy

  6. SOAP Serialization Performance Enhancement - Design And Implementation Of A Middleware

    Directory of Open Access Journals (Sweden)

    Behrouz Minaei

    2009-10-01

    Full Text Available The most straightforward way to improve performance of any system is to define the bottlenecks and think of ways to remove them. Web services are the inseparable part of any web application, as a result enhancing performance of web services will have a great effect on the overall performance of the system. The most widely used communication protocol in the web services model, SOAP, is a simple protocol for the exchange of messages. The serialization of large SOAP responses is a major performance bottleneck in a SOAP message exchange. Clearly, some web servers can expect to receive many similar messages for a particular web service as they share the same signature. The idea behind this paper is to avoid the redundant serialization stage of SOAP responses for request which have the same call parameters. The technique exploits the similarities between call parameters to improve web service Response Time by avoiding redundant serialization of the same response with the help of a middleware running on top of web server. The middleware will maintain a trie of incoming parameters for every set of current requests. This way request processing and serialization of the response of same requests will be done only once. In a nutshell, to serialize only the different responses is the simplest way to avoid extra work done by a serializer. It might worth noting that although our approach is to utilize the exact repeating portion parameters, the middleware can be configured to apply changes made to the result set of response to the serialized response being maintained in a trie to generate valid results.

  7. Serial intralesional injections of infliximab in small bowel Crohn’s strictures are feasible and might lower inflammation

    DEFF Research Database (Denmark)

    Hendel, Jakob; Karstensen, John Gásdal; Vilmann, Peter

    2014-01-01

    BACKGROUND: Crohn's disease can cause strictures throughout the gastrointestinal tract. Endoscopic balloon dilatation is a well-established treatment, but recurrence is seen in up to three out of four cases. Infliximab is playing an increasingly important role in the modern systemic treatment...... is feasible. OBJECTIVE: We wanted to assess whether serial intralesional injection of infliximab in small bowel strictures is feasible and reduces local inflammation. METHODS: We included six patients with Crohn's disease and inflammatory small bowel strictures. They were treated with endoscopic serial...... balloon dilatation. Subsequent to each dilatation, 40 mg infliximab was injected submucosally. A modified simplified endoscopic score for Crohn's disease was used for the involved area before the initial treatment and at the final follow-up after six months. Complications and development of symptoms were...

  8. On the classification of diseases.

    Science.gov (United States)

    Smart, Benjamin

    2014-08-01

    Identifying the necessary and sufficient conditions for individuating and classifying diseases is a matter of great importance in the fields of law, ethics, epidemiology, and of course, medicine. In this paper, I first propose a means of achieving this goal, ensuring that no two distinct disease-types could correctly be ascribed to the same disease-token. I then posit a metaphysical ontology of diseases-that is, I give an account of what a disease is. This is essential to providing the most effective means of interfering with disease processes. Following existing work in the philosophy of medicine and epidemiology (primarily Christopher Boorse; Caroline Whitbeck; Alexander Broadbent), philosophy of biology (Joseph LaPorte; D.L. Hull), conditional analyses of causation (J.L. Mackie; David Lewis), and recent literature on dispositional essentialism (Stephen Mumford and Rani Anjum; Alexander Bird), I endorse a dispositional conception of disease. Following discussion of various conceptions of disease-identity, their relations to the clinical and pathological effects of the diseases in question, and how diseases are treated, I conclude (i) that diseases should be individuated by their causes, and (ii) that diseases are causal processes best seen as simultaneously acting sequences of mutually manifesting dispositions.

  9. Hardware Implementation of Serially Concatenated PPM Decoder

    Science.gov (United States)

    Moision, Bruce; Hamkins, Jon; Barsoum, Maged; Cheng, Michael; Nakashima, Michael

    2009-01-01

    A prototype decoder for a serially concatenated pulse position modulation (SCPPM) code has been implemented in a field-programmable gate array (FPGA). At the time of this reporting, this is the first known hardware SCPPM decoder. The SCPPM coding scheme, conceived for free-space optical communications with both deep-space and terrestrial applications in mind, is an improvement of several dB over the conventional Reed-Solomon PPM scheme. The design of the FPGA SCPPM decoder is based on a turbo decoding algorithm that requires relatively low computational complexity while delivering error-rate performance within approximately 1 dB of channel capacity. The SCPPM encoder consists of an outer convolutional encoder, an interleaver, an accumulator, and an inner modulation encoder (more precisely, a mapping of bits to PPM symbols). Each code is describable by a trellis (a finite directed graph). The SCPPM decoder consists of an inner soft-in-soft-out (SISO) module, a de-interleaver, an outer SISO module, and an interleaver connected in a loop (see figure). Each SISO module applies the Bahl-Cocke-Jelinek-Raviv (BCJR) algorithm to compute a-posteriori bit log-likelihood ratios (LLRs) from apriori LLRs by traversing the code trellis in forward and backward directions. The SISO modules iteratively refine the LLRs by passing the estimates between one another much like the working of a turbine engine. Extrinsic information (the difference between the a-posteriori and a-priori LLRs) is exchanged rather than the a-posteriori LLRs to minimize undesired feedback. All computations are performed in the logarithmic domain, wherein multiplications are translated into additions, thereby reducing complexity and sensitivity to fixed-point implementation roundoff errors. To lower the required memory for storing channel likelihood data and the amounts of data transfer between the decoder and the receiver, one can discard the majority of channel likelihoods, using only the remainder in

  10. Alexander von Humboldt brachte Guano nach Europa - mit ungeahnten globalen Folgen

    Directory of Open Access Journals (Sweden)

    Bärbel Rott

    2016-05-01

    Full Text Available Zusammenfassung Die vorliegende Abhandlung beschäftigt sich mit einem bisher wenig beachteten Aspekt von Humboldts Amerikanischer Reise (1799─1804. Während seine Studien der Pflanzen- und Tierwelt bis heute große Aufmerksamkeit genießen, wird Humboldts Beitrag zu der Entwicklung der modernen Landwirtschaft wenig beachtet. Während seines Aufenthalts in Lima erhielt er Proben von Guano, Vogelmist von den Chincha-Inseln vor der peruanischen Küste. Einige Proben, die er von dieser Reise zurückbrachte, wurden von Wissenschaftlern in Frankreich und Deutschland untersucht. Die Analysenergebnisse zeigten außerordentlich hohe Gehalte an Pflanzennährstoffen, insbesondere Stickstoff und Phosphor. In den folgenden Jahrzehnten wurde Guano zu einem bedeutsamen Düngemittel und Auslöser eines Booms in Europa und Peru. Die Auswirkungen dieser Entwicklung sind bis heute sichtbar und werden hier unter besonderer Beachtung von Phosphor beschrieben. Abstract One aspect of Humboldt’s travel to South America (1799─1804 received little attention. The fascination of his studies of the South American flora and fauna is unbroken to the present day. Yet Humboldt’s contribution to modern agriculture remains almost unnoticed. During his stay in Lima Humboldt received samples of guano, a mixture of bird droppings from the Chincha Islands off the Peruvian coast, which he took to Europe and had analyzed by the most famous chemists in France and Germany. The results showed outstanding fertilizing effects, in particular due to the high content of nitrogen and phosphorus. The ensuing boom starting from the 1840s influenced agriculture in Europe and the economy of Peru seriously. Some aspects of this historical development may give an idea of the ensuing change not only in agriculture. Résumé Il y a un aspect du voyage de Alexander von Humboldt en Amérique du Sud (1799─1804 qui jusqu’à présent a été peu considéré. Ses études de la flore at le da

  11. Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography

    Directory of Open Access Journals (Sweden)

    Pardo Moira

    2007-01-01

    Full Text Available Abstract Cancer therapy has shown terrific progress leading to important reduction of morbidity and mortality of several kinds of cancer. The therapeutic management of oncologic patients includes combinations of drugs, radiation therapy and surgery. Many of these therapies produce adverse cardiovascular complications which may negatively affect both the quality of life and the prognosis. For several years the most common noninvasive method of monitoring cardiotoxicity has been represented by radionuclide ventriculography while other tests as effort EKG and stress myocardial perfusion imaging may detect ischemic complications, and 24-hour Holter monitoring unmask suspected arrhythmias. Also biomarkers such as troponine I and T and B-type natriuretic peptide may be useful for early detection of cardiotoxicity. Today, the widely used non-invasive method of monitoring cardiotoxicity of cancer therapy is, however, represented by Doppler-echocardiography which allows to identify the main forms of cardiac complications of cancer therapy: left ventricular (systolic and diastolic dysfunction, valve heart disease, pericarditis and pericardial effusion, carotid artery lesions. Advanced ultrasound tools, as Integrated Backscatter and Tissue Doppler, but also simple ultrasound detection of "lung comet" on the anterior and lateral chest can be helpful for early, subclinical diagnosis of cardiac involvement. Serial Doppler echocardiographic evaluation has to be encouraged in the oncologic patients, before, during and even late after therapy completion. This is crucial when using anthracyclines, which have early but, most importantly, late, cumulative cardiac toxicity. The echocardiographic monitoring appears even indispensable after radiation therapy, whose detrimental effects may appear several years after the end of irradiation.

  12. Genetic programming and serial processing for time series classification.

    Science.gov (United States)

    Alfaro-Cid, Eva; Sharman, Ken; Esparcia-Alcázar, Anna I

    2014-01-01

    This work describes an approach devised by the authors for time series classification. In our approach genetic programming is used in combination with a serial processing of data, where the last output is the result of the classification. The use of genetic programming for classification, although still a field where more research in needed, is not new. However, the application of genetic programming to classification tasks is normally done by considering the input data as a feature vector. That is, to the best of our knowledge, there are not examples in the genetic programming literature of approaches where the time series data are processed serially and the last output is considered as the classification result. The serial processing approach presented here fills a gap in the existing literature. This approach was tested in three different problems. Two of them are real world problems whose data were gathered for online or conference competitions. As there are published results of these two problems this gives us the chance to compare the performance of our approach against top performing methods. The serial processing of data in combination with genetic programming obtained competitive results in both competitions, showing its potential for solving time series classification problems. The main advantage of our serial processing approach is that it can easily handle very large datasets.

  13. Experimental demonstration of sequence recognition of serial memristors

    Science.gov (United States)

    Truong, Son Ngoc; Van Pham, Khoa; Yang, Wonsun; Jo, Anjae; Vo, Huan Minh; Lee, Mi Jung; Min, Kyeong-Sik

    2017-01-01

    The sequence recognition is very essential in mimicking brain's neocortical function because most of input patterns to brain's neocortex are dynamically changing over time, not static regardless of time. In this paper, we experimentally demonstrate the sequence recognition for various input sequences using serial memristors, for the first time. In this experiment, the serial memristors are used, which were fabricated with carbon fiber and aluminum film on glass substrate. To verify the sequence recognition, we store the following 3 sequences in the fabricated serial memristors, which are `A'→`B'→`C', `B'→`A'→`C', and `C'→`B'→`A', respectively. By performing this experiment, it is verified the serial memristors are changed to Low Resistance State only when the input sequence matches the stored one. When the input sequence is different from the stored one, the serial memristors remain unchanged. The simple voltage comparator can be used to sense the output voltage to indicate whether the sequence matching happens or not. This experimental demonstration can be very useful to realize memristor crossbars which can process the temporal and sequential patterns in future. [Figure not available: see fulltext.

  14. The relationship between serial sexual murder and autoerotic asphyxiation.

    Science.gov (United States)

    Myers, Wade C; Bukhanovskiy, Alexandr; Justen, Elle; Morton, Robert J; Tilley, John; Adams, Kenneth; Vandagriff, Virgil L; Hazelwood, Robert R

    2008-04-01

    This case series documents and examines the association between autoerotic asphyxiation, sadomasochism, and serial sexual murderers. Autoerotic asphyxiation, along with other paraphilias found in this population, is reviewed. Five cases of serial sexual killers who engaged in autoerotic asphyxiation were identified worldwide: four from the United States and one from Russia. Case reports for each are provided. All (100%) were found to have sexual sadism in addition to autoerotic asphyxiation. Furthermore, two (40%) had bondage fetishism, and two (40%) had transvestic fetishism, consistent with these paraphilias co-occurring in those with autoerotic asphyxiation. Overall the group averaged 4.0 lifetime paraphilias. Some possible relationships were observed between the offenders' paraphilic orientation and their modus operandi, e.g., all of these serial killers strangled victims-suggesting an association between their sadistic and asphyxiative paraphilic interests. The overlap of seemingly polar opposite paraphilias in this sample--sexual sadism and autoerotic asphyxiation--is explored from a historical and clinical perspective. Multiple commonalities shared between these five offenders and serial sexual murderers in general are addressed. A primary limitation of this study is its small sample size and empirical basis; the results may not be generalizable beyond the sample. The findings from this study support the supposition that crime scene behaviors often reflect paraphilic disturbances in those who commit serial sexual homicides.

  15. Towards time-resolved serial crystallography in a microfluidic device.

    Science.gov (United States)

    Pawate, Ashtamurthy S; Šrajer, Vukica; Schieferstein, Jeremy; Guha, Sudipto; Henning, Robert; Kosheleva, Irina; Schmidt, Marius; Ren, Zhong; Kenis, Paul J A; Perry, Sarah L

    2015-07-01

    Serial methods for crystallography have the potential to enable dynamic structural studies of protein targets that have been resistant to single-crystal strategies. The use of serial data-collection strategies can circumvent challenges associated with radiation damage and repeated reaction initiation. This work utilizes a microfluidic crystallization platform for the serial time-resolved Laue diffraction analysis of macroscopic crystals of photoactive yellow protein (PYP). Reaction initiation was achieved via pulsed laser illumination, and the resultant electron-density difference maps clearly depict the expected pR(1)/pR(E46Q) and pR(2)/pR(CW) states at 10 µs and the pB1 intermediate at 1 ms. The strategies presented here have tremendous potential for extension to chemical triggering methods for reaction initiation and for extension to dynamic, multivariable analyses.

  16. Violent cultural factors and serial homicide by males.

    Science.gov (United States)

    DeFronzo, James; Prochnow, Jane

    2004-02-01

    Explaining the phenomenon of male serial homicide has usually been approached from a psychiatric perspective. However, recent integrative theory suggests that cultural factors may play a role in shaping the psychology of young males with particular psychiatric and possibly neurological vulnerabilities in such ways as to facilitate converting the motivation to kill into actual behavior. Present results indicated that 34-45% of the interstate variation in rates of serial killer activity could be accounted for by three dimensions of local culture. Higher rates of male serial killer activity were associated with a local state culture supportive of game hunting and military training and a local culture supportive of punitive violence. The findings must be viewed with caution since societal variables are complex and the results are based on correlations which cannot be causally interpreted without more direct evidence of validity.

  17. A combination strategy for tracking the serial criminal

    Science.gov (United States)

    He, Chuan; Zhang, Yuan-Biao; Wan, Jiadi; Yu, Wenjing

    2010-08-01

    We build a Geographic Profiling Model to generate the criminal's geographical profile, by combining two complementary strategies: the Spatial Distribution Strategy and the Probability Distance Strategy. In the first strategy, we designate the mean of all the known crime sites as the anchor point, and build a Standard Deviational Ellipse Model, considering the effect of landscape. In the second strategy, we take many factors such as the buffer zone and distance decay theory into consideration and calculate the probability of the offender's residence in a certain area by using the Bayesian Theorem and the Rossmo Algorithm. Then, we combine the result of two strategies and get three search areas suit different conditions of the police to track the serial criminal. Apply the model to the English serial killer Peter Sutcliffe's case, the calculation result shows that the model can effectively be used to track serial criminal.

  18. Floating-point systolic array including serial processors

    Energy Technology Data Exchange (ETDEWEB)

    Leeland, S.B.

    1989-10-03

    This patent describes, in a systolic array system utilizing a plurality of semiconductor chips, a semiconductor chip. It comprises: a plurality of processing elements each including a floating-point serial processor and a plurality of data storage registers; global bus means coupled to the serial processor of each of the plurality of processing elements for inputing and outputing data to and from each chip and for programming each serial processor; and a plurality of data buses coupled to each of the plurality of data storage registers of each of the plurality of processing elements. The global bus means being coupled to the plurality of data storage registers for programming the data storage registers.

  19. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: The Alexander the First collection of the Lausanne Museum

    NARCIS (Netherlands)

    Minina, E.L.

    2004-01-01

    Study of written sources in archives sometimes allows to restore the history of collections. A good example is the Alexander the First collection. In 1819, de la Harpe had sent an Etruscan vase to Alexander I as a gift, and had received a collection of Russian minerals in return. Alexander's collect

  20. Alexander Graham Bell's Patent for the Telephone and Thomas Edison's Patent for the Electric Lamp. The Constitution Community: The Development of the Industrial United States (1870-1900).

    Science.gov (United States)

    Schur, Joan Brodsky

    In 1876 Americans held a Centennial Exhibition in Philadelphia (Pennsylvania) to celebrate the nation's birth 100 years earlier. Machinery Hall drew the most admiration and wonder. Alexander Graham Bell exhibited the first telephone, and Thomas Alva Edison presented the automatic telegraph, one of more than 1,000 inventions he would patent in his…

  1. The price of sin: listening to radio serials in secret

    OpenAIRE

    2006-01-01

    This paper deals with the use of radio serial scripts as a historical source that allows the analysis of the ways in which both particular social groups and their daily problems were broadcast and represented from '950 to '970. This period was clearly characterized by the centrality of radio as mass media, and of radio melodrama as the main broadcast genre in Latin America and, of course, in Colombia. Qur purpose is to classify the different radio serial stories, after doing a topical descrip...

  2. IT-based Value Creation in Serial Acquisitions

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Yetton, Philip

    2013-01-01

    The extant research on post-acquisition IT integration analyzes how acquirers realize IT-based value in individual acquisitions. However, serial acquirers make 60% of acquisitions. These acquisitions are not isolated events, but are components in growth-by-acquisition programs. To explain how...... serial acquirers realize IT-based value, we integrate and model the findings on individual acquisitions from the extant literature, and extend that model to explain the effects of sequential acquisitions in a growth-by-acquisition strategy. This extended model, drawing on the Resource-Based Theory...

  3. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Nakane, Takanori [The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Song, Changyong [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); POSTECH, Pohang 790-784 (Korea, Republic of); Suzuki, Mamoru [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871 (Japan); Nango, Eriko; Kobayashi, Jun [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Masuda, Tetsuya [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan); Inoue, Shigeyuki [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Mizohata, Eiichi [Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan); Nakatsu, Toru [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Tanaka, Tomoyuki; Tanaka, Rie [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Shimamura, Tatsuro [Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi [Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Hatsui, Takaki; Yabashi, Makina [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Nureki, Osamu [The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Iwata, So [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Sugahara, Michihiro, E-mail: msuga@spring8.or.jp [RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan)

    2015-11-27

    Sulfur SAD phasing facilitates the structure determination of diverse native proteins using femtosecond X-rays from free-electron lasers via serial femtosecond crystallography. Serial femtosecond crystallography (SFX) allows structures to be determined with minimal radiation damage. However, phasing native crystals in SFX is not very common. Here, the structure determination of native lysozyme from single-wavelength anomalous diffraction (SAD) by utilizing the anomalous signal of sulfur and chlorine at a wavelength of 1.77 Å is successfully demonstrated. This sulfur SAD method can be applied to a wide range of proteins, which will improve the determination of native crystal structures.

  4. Serial murder in America: case studies of seven offenders.

    Science.gov (United States)

    Beasley, James O

    2004-01-01

    This article summarizes and compares information on seven interviewed serial killers in an ongoing project designed to study similarities and differences among these individuals. The aim of this article is to increase our collective knowledge of the dynamics of serial murder by examining the perpetrators' backgrounds, as well as the unique ways in which they view themselves and the world around them. Although qualitative interview research alone is not sufficient to fully understand such behavior, it is useful in many ways. Some of the information discussed based on the seven offenders interviewed is compared with broader epidemiological studies, and the strengths and limitations of each type of research are discussed.

  5. Hallar e inventar a un público. Nuevos proyectos editoriales acerca de la obra de Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2008-10-01

    Full Text Available Article in español, abstracts in englisch, español and german.In Latin America, Alexander von Humboldt was and is known as one of the most famous historic and literary figures; in his own country, though, the acquaintance with his texts has until the 80s been reduced to groups of specialized scholars. Yet, for a couple of years, a growing interest in the works of Humboldt can be noticed, based on numerous new editions, which have been published since. Among others, these are the new edition of the Relation historique (1991, the editions of the „Humboldt Project“ (2004-2006 as part of the „Andere Bibliothek“, as well as current projects on German editions concerning Asie Centrale and the Examen critique.

  6. Jade aus Amerika und weitere Grünsteinobjekte von Alexander von Humboldt aus dem Berliner Mineralienkabinett

    Directory of Open Access Journals (Sweden)

    Renate Nöller

    2002-04-01

    Full Text Available Article in German, Abstracts in English, Spanish and German.Alexander von Humboldt sent samples of minerals from America not only for scientific or economic purposes. We also find carved pieces made out of green stone material known as Jade, that has been culturally very important in Mesoamerica. In Europe these green stone objects have been treated differently. The Jade-Celt and the Sun-Disc - known as “Humboldt-Axt” and “Humboldt-Scheibe” - both lost during the second world war, had gained great interest, whereas a small head-pendant - made out of Jade has been totally forgotten. The samples reflect the understanding of their worth in distinct cultural contexts.

  7. The evolution of ultrahigh carbon steels - from the Great Pyramids, to Alexander the Great, to Y2K

    Energy Technology Data Exchange (ETDEWEB)

    Wadsworth, J

    1999-10-01

    Hypereutectoid steels containing between about 1 and 2.1 wt%C, and now known as ultrahigh carbon steels (UHCS), have both a rich history (dating back to the time of Alexander the Great, i.e. {approximately} 300 BC) and an interesting, recent, technological period of development (from 1975 to the present). The connections between the modern UHCS and their ancient counterparts, and in particular Damascus steels, have received considerable attention. In addition to monolithic products, UHCS have also been used in both ancient and modern times in laminated composites. In the present paper, a summary of the modern development of UHCS and UHCS-containing laminates is given, and parallels are drawn with ancient materials. Also, ancient laminated composites containing other steels are described; controversial issues and a possible solution related to the age of such a laminate found in the Great Pyramid of Gizeh are discussed.

  8. Alexander von Humboldt y la génesis de la geografía física moderna

    OpenAIRE

    Antonio Carlos Vitte; Roberison Wittgenstein Dias da Silveira

    2011-01-01

    El artículo discute la formación de los conceptos de la naturaleza, espacio y morfología en la obra de Alexander von Humboldt y sus impactos en la constitución de la geografía física moderna. Influido por las reflexiones de Kant en la Crítica del Juicio, por los trabajos de Goethe y de Schelling, Humboldt desarrollará una nueva interpretación y representación de la naturaleza en la superficie terrestre, donde el concepto de espacialidad será fundamental para la explicación de los fenómenos de...

  9. The appearance of the artist to the people: the creativity, personality and malady of Alexander Ivanov (1806-58).

    Science.gov (United States)

    Lerner, Vladimir; Witztum, Eliezer

    2005-02-01

    Alexander Ivanov was an outstanding Russian painter who lived in the middle of the nineteenth century, during the romantic period. He did not accept romanticism but instead tried to create his own original style, an ambitious combination of spiritual profundity and a manner of execution unparalleled in Western European art. Ivanov's intention and style are best reflected in his major work The Appearance of Christ to the People, a picture on which he worked for over 20 years. He painted more than 400 sketches of the picture while attempting to bring his masterpiece to perfection. At the end of his life Ivanov became disillusioned, renounced his strong religious conviction and became suspicious. This study examines the influence of his background, life story and personality on the creative process. From a diagnostic perspective, Ivanov's personality featured obsessive, narcissistic and schizoid traits. In his final years he suffered from a delusional disorder.

  10. James Sowerby: meteorites and his meteoritic sword made for the Emperor of Russia, Alexander I, in 1814

    Science.gov (United States)

    Henderson, Paul

    2013-01-01

    James Sowerby included meteorites in his publications of British and exotic natural history and so raised interest in their nature and origins at a time of much debate and involving the President of the Royal Society, Sir Joseph Banks. The celebrations over the defeat of France in 1814 prompted Sowerby to make a sword from the Cape of Good Hope iron meteorite to present to the Russian Emperor, Alexander I, at the time of his state visit to London in June 1814 and in recognition of his achievements in bringing peace to Europe. The story of its attempted presentation, its final reception and the following response, including publications, all helped to increase interest in meteorites and their properties. The rediscovery of the sword after a lengthy disappearance probably brings an unusual saga to a fitting close.

  11. Alexander von Humboldt y la génesis de la geografía física moderna

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Vitte

    2010-10-01

    Full Text Available Article in Spanish. AbstractThis article discusses the genesis of modern physical geography since the formation of the concepts of nature, space and morphology in the writings of Alexander von Humboldt. Influenced by the reflections of Kant in the “Critique of Judgment”, the writings of Goethe and Schelling, Humboldt has developed a new interpretation and representation of nature in the earth’s surface that turned the concept of space out to be crucial to the explanation of the phenomena of nature. A complex starting point of influences as such aesthetics or self developed instrumentals has structured modern Physical Geography through a principle of connection between artistic and scientific invention in the geographic concept of landscape.

  12. Non-Euclidean Space, Movement and Astronomy in Modern Art: Alexander Calder's Mobiles and Ben Nicholson's Reliefs

    Science.gov (United States)

    Malloy, Vanja

    2013-09-01

    John Keats once wrote that `there is no such thing as time and space' rather, believing that time and space are mental constructs that are subject to a variety of forms and as diverse as the human mind. In the 1920s through the 1930s, modern physics in many ways supported this idea through the various philosophical writings on the Theory of General Relativity to the masses by scientists such as Arthur Eddington and Albert Einstein. These new concepts of modern physics fundamentally changed our understanding of time and space and had substantial philosophical implications, which were absorbed by modern artists resulting in the 1936 Dimensionist Manifesto. Seeking to internalize the developments of modern science within modern art, this manifesto was widely endorsed by the most prominent figures of the avant-garde such as Marcel Duchamp, Jean Arp, Naum Gabo, Joan Miró, László Moholy-Nagy, Wassily Kandinsky and Alexander Calder. Of particular interest to this manifesto was the new concept of the fourth-dimension, which in many ways revolutionized the arts. Importantly, its interpretation varied widely in the artistic community, ranging from a purely physical four-dimensional space, to a kinetic concept of space in which space and time are linked, to a metaphysical interest in a space that exists beyond the material realm. The impact of modern science and astronomy on avant-garde art is currently a bourgeoning area of research with considerable implications to our rethinking of substantial artistic figures of this era. Through a case study of Alexander Calder's Mobiles and Ben Nicholson's Reliefs, this paper explores how these artworks were informed by an interest in modern science.

  13. Painting Style of Alexander Colville%亚历克斯·科尔维尔的绘画风格

    Institute of Scientific and Technical Information of China (English)

    江严冰

    2016-01-01

    Alexander Colville is one of the most famous artists in contemporary Canada. His works are of an exquisite painting style and diverse themes, most of which focus on real life to convey his relatively constant creation in-tention. All his works are designed and composed by rational means to form cool pictures with a sense of order. Alexan-der Colville is one of a small number of artists who connect time and space together in the contemporary era. He repro-duces ordinary life scenes in his paintings with unique techniques and inventive treatment, making his works have an un-realistic meaning remarkably different from the real life and thus successfully conveying the sense of alienation between people in the modern society.%科尔维尔是加拿大当今最著名的画家之一。他的作品画风细腻,题材多样,多是围绕现实生活展开创作,传达出相对恒定的创作意图。作品通过理性的手段规划构图,形成冷峻而有秩序感的画面。画中平常的生活场景由于画家的独特手法及其独具匠心的处理而意味非常。他成功地将现代社会人与人之间的疏离感传达出来,是当代为数不多的将时间与空间关联在一起的画家。

  14. Steers performance fed diets with Alexander grass silage (Urochloa plantaginea x sorghum silage (Sorghum bicolor (L. Moench

    Directory of Open Access Journals (Sweden)

    Flânia Mônego Argenta

    2014-02-01

    Full Text Available This study aimed to evaluate the parameters related to feedlot beef steers fed with Alexander grass silage or sorghum silage as roughage source. Twelve animals with initial average of weight and age of 245 kg and 20 months, respectively, belonging to Nellore (N, Charolais (C, 21/32 N 11/32 C, 21/32 C 11/32 N; 43/64 N 21/64 C and 43/64 C 21/64 N genetic groups were used. The ration was composed by a roughage:concentrate relation of 50:50 (dry matter basis, offered at ease. The dry matter, crude protein, ether extract, neutral detergent fiber and acid detergent fiber daily intake didn’t differ between roughage sources, being the medium values of 10.18; 1.28; 0.20; 4.96 and 2.51 kg/day, respectively. However, the ether extract intake by metabolic size and by corporal weight percentage were higher for the one that consumed sorghum silage, obtaining values of 2.74 and 2.36 g/metabolic size and 0.06 and 0.05 kg/100 kg of live weight. The same behavior was observed for digestible energy intake, presenting values of 364.87 and 302.83 g/metabolic size and 8.10 and 7.02 kg/100 kg of live weight. The daily average gain, final corporal score and feed conversion weren’t influenced by roughage type, being the values of 1.31 kg; 4.05 points and 7.78 kg of DM/kg of weight gain, respectively. The Alexander grass silage is a feasible alternative as its substitution in relation to sorghum silage.

  15. Parallel-to-serial biphase-data converter

    Science.gov (United States)

    Truelove, R. D.

    1968-01-01

    Data converter produces a serial biphase output signal from parallel input data. Alternate bits are loaded into a shift register in complement form so that the bits appear at the end of the shift register in a true-complement form sequence.

  16. Kiondo Bag Boutique: A Serial Case for Introductory Financial Accounting

    Science.gov (United States)

    Siriwardane, Harshini P.

    2014-01-01

    Kiondo Bag Boutique is a hypothetical serial case involving a start-up retail business. The case evolves from an ambitious business idea to a successful business. Through the evolving business, the importance of accounting information is highlighted. Different iterations are used to illustrate the role of accounting in serving and managing…

  17. DC and RF Measurements of Serial Bi-SQUID Arrays

    CERN Document Server

    Prokopenko, G V; de Escobar, A Leese; Taylor, B; de Andrade, M C; Berggren, S; Longhini, P; Palacios, A; Nisenoff, M; Fagaly, R L

    2012-01-01

    SQUID arrays are promising candidates for low profile antennas and low noise amplifier applications. We present the integrated circuit designs and results of DC and RF measurements of the wideband serial arrays based on integration of linear bi-SQUID cells forming a Superconducting Quantum Interference Filter (bi-SQUID SQIF). Various configurations of serial arrays designs are described. The measured linearity, power gain, and noise temperature are analyzed and compared. The experimental results are matched to results of mathematical modeling. A serial bi-SQUID SQIF arrays are mounted into a coplanar waveguide (CPW) and symmetrically grounded to corresponding sides of CPW. The RF output comes out from the central common line, which is also used for DC biasing and forms a symmetrical balanced output. The signal and DC flux biasing line is designed as coplanar lines passed in parallel over each bi-SQUID cell in a bidirectional fashion concentrating magnetic flux inside of each cell. Serial bi-SQUID SQIF arrays ...

  18. Phonological Similarity in Serial Recall: Constraints on Theories of Memory

    Science.gov (United States)

    Lewandowsky, Stephan; Farrell, Simon

    2008-01-01

    In short-term serial recall, similar-sounding items are remembered more poorly than items that do not sound alike. When lists mix similar and dissimilar items, performance on the dissimilar items is of considerable theoretical interest. Farrell and Lewandowsky [Farrell, S., & Lewandowsky, S. (2003). Dissimilar items benefit from phonological…

  19. STUDY ON SERIAL ULTRASONOGRAPHI EXAMINATION FOR MONITORING OF OVULATION

    Institute of Scientific and Technical Information of China (English)

    ZHOUCan-Quan; LIANGGui-Shang; ZHAOJie-Rong

    1989-01-01

    27 womea, aged from 24 to 34 years, with normal menstrual cycle were observed on thegrowth development and ovulation of Graffian follicles by serial ultrasonographic examination. The cyclic changes of thor serum concentration of LH, FSH, E2 and P were

  20. FPGA based fast synchronous serial multi-wire links synchronization

    Science.gov (United States)

    Pozniak, Krzysztof T.

    2013-10-01

    The paper debates synchronization method of multi-wire, serial link of constant latency, by means of pseudo-random numbers generators. The solution was designed for various families of FPGA circuits. There were debated synchronization algorithm and functional structure of parameterized transmitter and receiver modules. The modules were realized in VHDL language in a behavioral form.

  1. 'American Psycho': a double portrait of serial yuppie Patrick Bateman

    NARCIS (Netherlands)

    J. Kooijman; T. Laine

    2003-01-01

    Kooijman and Laine analyze Mary Harron's "American Psycho," a 2000 film adaptation of the 1980s satirical novel by Bret Easton Ellis in which Patrick Bateman, a narcissistic Wall Street young urban professional ("yuppie"), assumes an alternate identity as a serial killer. The authors examine the dou

  2. Asymmetric binding in serial memory for verbal and spatial information

    NARCIS (Netherlands)

    Guerard, Katherine; Morey, Candice C.; Lagace, Sebastien; Tremblay, Sebastien

    2013-01-01

    As the number of studies showing that items can be retained as bound representations in memory increases, researchers are beginning to investigate how the different features are bound together. In the present study, we examined the relative importances of the verbal and spatial features in serial me

  3. Bit Serial Architecture for Variable Block Size Motion Estimation

    Directory of Open Access Journals (Sweden)

    Krishna Kaveri Devarinti

    2013-06-01

    Full Text Available H.264/AVC is the latest video coding standard adopting variable block size, quarter-pixel accuracy and motion vector prediction and multi-reference frames for motion estimations. These new features result in higher computation requirements than that for previous coding standards.The computational complexity of motion estimation is about 60% in the H.264/AVC encoder. In this paper most significant bit (MSB first arithmetic based bit serial Variable Block Size Motion Estimation (VBSME hardware architecture is proposed. MSB first bit serial architecture main feature is, its early termination SAD computation compared to normal bit serial architectures. With this early termination technique, number computations are reduced drastically. Hence power consumption is also less compared to parallel architectures. An efficient bit serial processing element is proposed and developed 2D architecture for processing of 4x4 block in parallel .Inter connect structure is developed in such way that data reusability is achieved between PEs. Two types of adder trees are employed for variable block size SAD calculation with less number of adders. The proposed architecture can generate up to 41 motion vectors (MVs for each macroblock. The inter connection complexity between PEs reduced drastically compared to parallel architectures. The architecture supports processing of SDTV (640x480 with 30fps at 172.8 MHz for search range [+8, -7]. We could reduce 14% of computations by using early termination technique.

  4. On the Asymmetry of Serial Verbs in the Edo Language.

    Science.gov (United States)

    Stewart, Osamuyimen Thompson

    The serial verb construction (SVC) in Edo (Bini), a language spoken in Nigeria, is examined, and an analysis that systematically characterizes the notion of functional relationship of verbs within these constructions is proposed. It is argued that the verbs in series are sensitive to different semantic and grammatical phenomena and are therefore…

  5. Rank-based entropy tests for serial independence

    NARCIS (Netherlands)

    Diks, C.; Panchenko, V.

    2008-01-01

    In nonparametric tests for serial independence the marginal distribution of the data acts as an infinite dimensional nuisance parameter. The decomposition of joint distributions in terms of a copula density and marginal densities shows that in general empirical marginals carry no information on depe

  6. Whole-pattern fitting technique in serial femtosecond nanocrystallography

    Directory of Open Access Journals (Sweden)

    Ruben A. Dilanian

    2016-03-01

    Full Text Available Serial femtosecond X-ray crystallography (SFX has created new opportunities in the field of structural analysis of protein nanocrystals. The intensity and timescale characteristics of the X-ray free-electron laser sources used in SFX experiments necessitate the analysis of a large collection of individual crystals of variable shape and quality to ultimately solve a single, average crystal structure. Ensembles of crystals are commonly encountered in powder diffraction, but serial crystallography is different because each crystal is measured individually and can be oriented via indexing and merged into a three-dimensional data set, as is done for conventional crystallography data. In this way, serial femtosecond crystallography data lie in between conventional crystallography data and powder diffraction data, sharing features of both. The extremely small sizes of nanocrystals, as well as the possible imperfections of their crystallite structure, significantly affect the diffraction pattern and raise the question of how best to extract accurate structure-factor moduli from serial crystallography data. Here it is demonstrated that whole-pattern fitting techniques established for one-dimensional powder diffraction analysis can be feasibly extended to higher dimensions for the analysis of merged SFX diffraction data. It is shown that for very small crystals, whole-pattern fitting methods are more accurate than Monte Carlo integration methods that are currently used.

  7. The stand-alone test and decreasing serial cost sharing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Thorlund-Petersen, Lars

    2000-01-01

    The rule of decreasing serial cost sharing defined in de Frutos [1] over the class of concave cost functions may violate the important stand-alone test. Sufficient conditions for the test to be satisfied are given, in terms of individual rationality as well as coalitional stability. These conditi....... These conditions restrict the shape of the cost function and the distribution of demands...

  8. Context dependent learning in the serial RT task

    NARCIS (Netherlands)

    Abrahamse, Elger L.; Verwey, Willem B.

    2007-01-01

    This study investigated the development of contextual dependencies for sequential perceptual-motor learning on static features in the learning environment. In three experiments we assessed the eVect of manipulating task irrelevant static context features in a serial reaction-time task. Experiment 1

  9. Ultra-high-speed serial optical communications: Enabling technologies

    DEFF Research Database (Denmark)

    Oxenløwe, Leif Katsuo; Galili, Michael; Mulvad, Hans Christian Hansen;

    2008-01-01

    This paper will present recently identified and demonstrated key technologies for ultra-high-speed serial communications. Certain key components such as stabilised highly non-linear fibre switches, periodically poled Lithium Niobate devices and semiconductor optical amplifiers will be described w...

  10. Analysis of aging in lager brewing yeast during serial repitching.

    Science.gov (United States)

    Bühligen, Franziska; Lindner, Patrick; Fetzer, Ingo; Stahl, Frank; Scheper, Thomas; Harms, Hauke; Müller, Susann

    2014-10-10

    Serial repitching of brewing yeast inoculates is an important economic factor in the brewing industry, as their propagation is time and resource intensive. Here, we investigated whether replicative aging and/or the population distribution status changed during serial repitching in three different breweries with the same brewing yeast strain but different abiotic backgrounds and repitching regimes with varying numbers of reuses. Next to bud scar numbers the DNA content of the Saccharomyces pastorianus HEBRU cells was analyzed. Gene expression patterns were investigated using low-density microarrays with genes for aging, stress, storage compound metabolism and cell cycle. Two breweries showed a stable rejuvenation rate during serial repitching. In a third brewery the fraction of virgin cells varied, which could be explained with differing wort aeration rates. Furthermore, the number of bud scars per cell and cell size correlated in all 3 breweries throughout all runs. Transcriptome analyses revealed that from the 6th run on, mainly for the cells positive gene expression could be seen, for example up-regulation of trehalose and glycogen metabolism genes. Additionally, the cells' settling in the cone was dependent on cell size, with the lowest and the uppermost cone layers showing the highest amount of dead cells. In general, cells do not progressively age during extended serial repitching.

  11. Child serial murder-psychodynamics: closely watched shadows.

    Science.gov (United States)

    Turco, R

    2001-01-01

    There is a malignant transformation in object relations resulting in an identification with an omnipotent and cruel object resulting in an identity transformation. If the tension, desperation, and dissociation increase, serial murder becomes spree murder. The presence of pathological narcissism and psychopathic tendencies are of diagnostic significance in understanding the murderer's personality functioning and motivation to kill. Meloy (1988) considered the degree of sadism and aggression combined with narcissistic qualities to reflect the "malignancy" of the psychopathic disturbance where gratification (of aggression) occurs in the service of narcissistic functioning--that is, cruelty toward others in the form of a triumphant victory over a rejecting object. Meloy also believes that dissociation is ubiquitious in the psychopath. The initial murder of the serial murderer may reflect a "new identity." The pathological object-relations of narcissism and the malignant narcissism are important diagnostic indicators in the personality functioning of serial killers and the occurrence of these phenomena is a significant factor in the formation of the personalities of serial killers, their inner motivations, and their pattern of commission.

  12. Serial Killers: Academic Libraries Respond to Soaring Costs.

    Science.gov (United States)

    McCarthy, Paul

    1994-01-01

    Discusses ways in which academic libraries are responding to rising costs of serials. Topics addressed include pricing by publishers; the effect of journal cancellations on research activities; interlibrary loans and document delivery services; coordinated cancelling; electronic journals; and experiences at the University of Arizona. (LRW)

  13. Experiment und Wissensvermittlung. Alexander von Humboldts Darstellungsmethoden in seinen Versuchen über die gereizte Muskel- und Nervenfaser

    Directory of Open Access Journals (Sweden)

    Alexander Stöger

    2016-11-01

    Full Text Available Zusammenfassung Alexander von Humboldt hat sich in jungen Jahren mit galvanischen Experimenten beschäftigt und die Resultate in einem umfassenden, zweibändigen Werk publiziert. Dabei zeigte er nicht nur, dass er als Experimentator und Teil der wissenschaftlichen Gemeinschaft fähig war, sich mit einem so neuen und komplexen Phänomen zu beschäftigen. Es lässt sich auch erkennen, dass er bereits in dieser frühen Schrift versuchte, das umfangreiche Wissen dem Leser zugänglich zu machen. Der Artikel betrachtet Humboldts Galvanismusschrift Versuche über die gereizte Muskel- und Nervenfaser (1797–1798 und untersucht einige Elemente wie Anhänge und Schreibstil, die Humboldt nutzte, um die umfangreichen Informationen zu ordnen und dem Leser so neben den Big Data seiner Erkenntnisse auch passende Suchfunktionen zur Verfügung zu stellen, die eine gezielte Nutzung überhaupt ermöglichen.  Abstract In the early stages of his scientific career, Alexander von Humboldt took an interest in experiments in galvanism. He publicised the results in a two-volume work under the title Versuche über die gereizte Muskel- und Nervenfaser (Experiments on the Stimulated Muscle and Nerve Fibre in 1797 and 1798. In this treatise, he presented himself as competent experimenter and member of the scientific community, but also demonstrated that he was capable of researching new and complex phenomena. These volumes also provide insight into his early attempts to facilitate the readers’ access to the extensive information he had compiled. This article analyses some aspects of Humboldt’s efforts to arrange his vast numbers of observations and theories, for example by means of appendices and narrative style, which he used not only to present the resulting big data collected during his research, but also to make it possible for the reader to organise and utilise this data.   Resumen A temprana edad Alexander von Humboldt se dedicó a galvanismo. En 1797 y 1798

  14. Development of CONSER Cataloging Policies for Remote Access Computer File Serials.

    Science.gov (United States)

    Anderson, Bill; Hawkins, Les

    1996-01-01

    Describes the development of CONSER (Cooperative Online Serials) policies and practices for cataloging remote access computer file serials. Topics include electronic serials on the Internet, cataloging standards for computer files, OCLC and Internet resources, networked resources as published documents, multiple file formats, sources of…

  15. Shakespeare à l’écran : Makibefo d’Alexander Abela, un exemple extrême d’appropriation culturelle Alexander Abela’s Makibefo: an Example of Radical Cultural Appropriation on Screen

    Directory of Open Access Journals (Sweden)

    Anne-Marie Costantini-Cornède

    2009-06-01

    Full Text Available Alexander Abela’s Makibefo (1999 shot in Madagascar and played by non-professional actors. The use of the Antandroy people or “an ancient tribe” who had never even seen a film before, is an example of cultural appropriation or a “transcultural” approach to the play, a complex process of rewriting which consists in a narrative and aesthetic remoulding of the play adapted. By transposing the play Macbeth to an unusual context, a poor fishermen’s village lost at the other end of the world, the filmmaker means to enhance its mythic and universal dimension. He resorts to various narrative and aesthetic strategies such as plot displacements, character suppressions or dialogue simplifications as well as ample and systematic use of cinematic rhetoric (camera movements, framing and angle shot effects or light contrasts, which helps create a filmic mode. The process is paradoxical, as it is not so much meant to deconstruct the play as to reconstruct its essential meaning in a novel, powerful and visionary way, thus offering an alternative reading of the play.

  16. An efficient ternary serial adder based on carbon nanotube FETs

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Moaiyeri

    2016-03-01

    Full Text Available This paper presents an efficient ternary serial adder for nanotechnology employing negative, positive and standard ternary logics. Multiple-valued logic results in chips with more density, less complexity and high-bandwidth data transfer. The unique properties of CNTFETs such as the capability of adapting the desired threshold voltage by changing the diameters of the nanotubes and same carrier mobility for the n-type and p-type devices play an important role in designing this circuit. The proposed design method considerably reduces the number of required devices of a ternary serial adder. In addition, the results of the simulations conducted using HSPICE with the Stanford comprehensive 32 nm CNTFET model, demonstrate improvements in terms of speed and power-delay product as compared to the cutting-edge CNTFET-based ternary designs.

  17. Plastic optical fiber serial communications link for distributed control system

    Science.gov (United States)

    Saxena, Piyush; Sharangpani, K. K.; Vora, H. S.; Nakhe, S. V.; Jain, R.; Shenoy, N. M.; Bhatnagar, R.; Shirke, N. D.

    2001-09-01

    One of the most common interface for communications specified is RS 232C standard. Though widely accepted, RS232 has limited transmission speed, range and networking capabilities. RS 422 standard overcomes limitations by using differential signal lines. In automation of the operation of gas discharge lasers, multiple processors are used for control of lasers, cooling system, vacuum system etc. High EMI generated by lasers interfere through galvanic transmission or by radiation over the length of cables, and hang up operation of processors or control PC. A serial communications link was designed eliminating copper transmission media, using plastic optical fiber cables and components, to connect local controllers with the master PC working on RS232 protocols. The paper discusses the design and implementation of a high ly reliable EMI harden serial communications link.

  18. Dental identification in serial homicides: the Green River Murders.

    Science.gov (United States)

    Rothwell, B R; Haglund, W; Morton, T H

    1989-09-01

    At least 40 young women have died at the hands of a serial killer in what has been called the Green River Murders. Because most of the victims' remains were severely decomposed with partial or complete skeletonization and little or no personal effects were recovered, forensic odontologic methods played a key role in their identifications. Although numerous methods were used to accumulate leads to the identities of the badly decomposed skeletonized remains, leads generated through traditional investigative methods established the identities in most cases. Of 40 victims, 36 have now been identified, mainly by means of dental evidence. This article details the challenges presented by serial homicides and the key role of forensic odontologic methods in the Green River Murders investigation.

  19. Jacob--the case of a serial killer.

    Science.gov (United States)

    Kallian, M; Bar-el, Y C; Durst, R; Witztum, E

    1996-01-01

    This paper describes a rare forensic psychiatric syndrome which has been the subject of massive publicity in the last decade. Despite the widespread interest, the psychodynamic process whereby a person becomes a serial murderer remains largely unknown. "Jacob" was convicted of a series of murders that he carried out over a decade. The case material is based on the psychiatric reports that were presented to the court and the many articles published in the local press at the time. Despite the limitations imposed by the material, the available information on "Jacob" bears some similarity to the phenomenological and psychodynamic models described in the literature. An attempt is made to understand the transformation of a person into a serial killer considering the life events, psychopathology and stressors that lead to the emergence from the world of imagination and fantasy of a potential murderer to the deeds that comprise the syndrome.

  20. Lipidic cubic phase serial millisecond crystallography using synchrotron radiation

    Directory of Open Access Journals (Sweden)

    Przemyslaw Nogly

    2015-03-01

    Full Text Available Lipidic cubic phases (LCPs have emerged as successful matrixes for the crystallization of membrane proteins. Moreover, the viscous LCP also provides a highly effective delivery medium for serial femtosecond crystallography (SFX at X-ray free-electron lasers (XFELs. Here, the adaptation of this technology to perform serial millisecond crystallography (SMX at more widely available synchrotron microfocus beamlines is described. Compared with conventional microcrystallography, LCP-SMX eliminates the need for difficult handling of individual crystals and allows for data collection at room temperature. The technology is demonstrated by solving a structure of the light-driven proton-pump bacteriorhodopsin (bR at a resolution of 2.4 Å. The room-temperature structure of bR is very similar to previous cryogenic structures but shows small yet distinct differences in the retinal ligand and proton-transfer pathway.

  1. Serial Nuclear Transfer of Goat-Rabbit Interspecies Reconstructed Embryos

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhi-guo; CHENG Li-zi; ZHANG Xiao-rong; LIU Ya; JING Ren-tao; WANG Cun-li; ZHAO Huan; LI Bin; CAO Chen-chong; LI Dong-wei

    2005-01-01

    The experiments of serial nuclear transfer were conducted between Boer goat and rabbit. The enucleated oocytes of rabbit were used as recipients while the blastomeres of goat morula was used as nuclear donor. The reconstructed embryos developing to morula were used as donor for serial cloning. As a result, two generations of reconstructed embryos were obtained, including 58 first generation reconstructed embryos and 14 second generation reconstructed embryos. The fusion rates were 79.5 and 70%, respectively. and there was no significant difference between them (P>0.05). The cleavage rates were 75.9 and 28.6% respectively with significant difference (P<0.01). No blastocyst was obtained from the second generation reconstructed embryos while 13.8% of first generation reconstructed embryos developed to blastocyst.

  2. Freeing the Serial Mechanism Designer from Inverse Kinematic Solvability Constraints

    Directory of Open Access Journals (Sweden)

    Diana C. W. Friedman

    2010-01-01

    Full Text Available This paper presents a fast numerical solution for the inverse kinematics of a serial manipulator. The method is implemented on the C-arm, a manipulator designed for use in robotic surgery. The inverse kinematics solution provides all possible solutions for any six degree-of-freedom serial manipulator, assuming that the forward kinematics are known and that it is possible to solve for the remaining joint angles if one joint angle’s value is known. With a fast numerical method and the current levels of computing power, designing a manipulator with closed-form inverse kinematics is no longer necessary. When designing the C-arm, we therefore chose to weigh other factors, such as actuator size and patient safety, more heavily than the ability to find a closed-form inverse kinematics solution.

  3. Low-Stroke Actuation for a Serial Robot

    Science.gov (United States)

    Gao, Dalong (Inventor); Ihrke, Chris A. (Inventor)

    2014-01-01

    A serial robot includes a base, first and second segments, a proximal joint joining the base to the first segment, and a distal joint. The distal joint that joins the segments is serially arranged and distal with respect to the proximal joint. The robot includes first and second actuators. A first tendon extends from the first actuator to the proximal joint and is selectively moveable via the first actuator. A second tendon extends from the second actuator to the distal joint and is selectively moveable via the second actuator. The robot includes a transmission having at least one gear element which assists rotation of the distal joint when an input force is applied to the proximal and/or distal joints by the first and/or second actuators. A robotic hand having the above robot is also disclosed, as is a robotic system having a torso, arm, and the above-described hand.

  4. [Some criminological and psychopathologic reflexions about serial crimes].

    Science.gov (United States)

    Romi, Juan Carlos

    2011-01-01

    This article reviews the concept of serial crime, including murder as well as any action for the purpose of inflicting bodily harm upon any person. It characterizes three types of multi-murderers: serial killers, mass murderers, and spree killers. These offenders often have a specific (ritual) behavior that is idiosyncratic and repeated on each crime, which allows the psychological profiling of the murderer. Examples, a psychopathological background, and a description of both their criminal behavior and dynamics are provided for each of these criminals. They are further classified according to their different motivations: psychotic, prophetic or enlightened, pleasure, secondary or pecuniary profits, power or control. Finally, the author shares his personal experience over 20 years in the assessment of sexual offenders.

  5. „Warum ich nicht Diorit-Trachyt sagen soll.“ – Ein geologischer Brief Gustav Roses an Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Konstantin Treuber

    2014-08-01

    Full Text Available Zusammenfassung Gustav Rose (1798-1873 begleitete Alexander von Humboldt auf seiner Russlandreise und stand bis zu Humboldts Tod persönlich und postalisch zum ihm in Kontakt. Die Edition des vorliegenden Briefs zielt darauf ab, die Bedeutung der Person Gustav Rose in ihrer Beziehung zu Alexander von Humboldt und ihrem Einfluss auf den mineralogisch-geologischen Teil des Kosmos zu beleuchten und dem Leser dieses interessante historische Dokument zugänglich zu machen. Abstract Gustav Rose (1798-1873 accompanied Humboldt on his journey to Russia. He kept in touch with Humboldt after this expedition until Humboldt died in 1859. The edition of the letter at hand aims at highlighting Rose’s relation to Humboldt and how he influenced the geological and mineralogical part of the Kosmos. It shall also make this impressive historical document accessible to readers by providing illustrating annotations.

  6. Evaluating return on investment in a school based health promotion and prevention program: the investment multiplier for the Stephanie Alexander Kitchen Garden National Program.

    Science.gov (United States)

    Eckermann, Simon; Dawber, James; Yeatman, Heather; Quinsey, Karen; Morris, Darcy

    2014-08-01

    Successful health promotion and disease prevention strategies in complex community settings such as primary schools rely on acceptance and ownership across community networks. Assessing multiplier impacts from investment on related community activity over time are suggested as key alongside evidence of program health effects on targeted groups of individuals in gauging community network engagement and ownership, dynamic impacts, and program long term success and return on investment. An Australian primary school based health promotion and prevention strategy, the Stephanie Alexander Kitchen Garden National Program (SAKGNP), which has been providing garden and kitchen classes for year 3-6 students since 2008, was evaluated between 2011 and 2012. Returns on Australian Federal Government investment for school infrastructure grants up to $60,000 are assessed up to and beyond a two year mutual obligation period with: (i) Impacts on student lifestyle behaviours, food choices and eating habits surveyed across students (n = 491 versus 260) and parents (n = 300 versus 234) in 28 SAKGNP and 14 matched schools, controlling for school and parent level confounders and triangulated with SAKGNP pre-post analysis; (ii) Multiplier impacts of investment on related school and wider community activity up to two years; and (iii) Evidence of continuation and program evolution in schools observed beyond two years. SAKGNP schools showed improved student food choices (p = 0.024) and kitchen lifestyle behaviour (p = 0.019) domains compared to controls and in pre-post analysis where 20.0% (58/290) reported eating fruit and vegetables more often and 18.6% (54/290) preparing food at home more often. No significant differences were found in case control analysis for eating habits or garden lifestyle behaviour domains, although 32.3% of children helped more in the garden (91/278) and 15.6% (45/289) ate meals together more often in pre-post analysis. The multiplier impact on total

  7. Acute Cholecystitis Detected by Serial Emergency Department Focused Right Upper Quadrant Ultrasound

    Directory of Open Access Journals (Sweden)

    David Bosch

    2016-06-01

    Full Text Available Acute cholecystitis is a common etiology of acute right upper quadrant pain in patients presenting to the emergency department (ED. The use of ED-focused right upper quadrant ultrasound (RUQ US is becoming more widely utilized to evaluate abdominal pain thought to be hepatobiliary in nature. We describe a case series of two patients with acute cholecystitis detected by serial ED-focused RUQ US. Case 1: A woman presented to the ED with epigastric pain of acute onset. She was initially found to have a mild leukocytosis and cholelithiasis detected by ED-focused RUQ US. Seventy-five minutes later, the patient had a repeat bedside ultrasound by the same sonographer that showed visual evidence of acute cholecystitis that was later confirmed by surgical pathology. She was treated operatively. Case 2: A man with known cholelithiasis presents to the ED with acute-onset RUQ pain. Initial RUQ ultrasound performed by the Department of Radiology (University of Colorado Hospital was equivocal, showing cholelithiasis with a mildly thickened wall and no pericholecystic fluid. A repeat ED-focused RUQ ultrasound 5 hours later showed increased wall thickness and pericholecystic fluid. The patient was subsequently taken for same-day cholecystectomy. This case series demonstrates the dynamic and progressive nature of acute cholecystitis detected by ED-focused RUQ US. It also highlights how serial bedside ultrasonography can reduce harm, appropriately triage patients with hepatobiliary disease and lead to reductions in overall morbidity.

  8. Serial Section Registration of Axonal Confocal Microscopy Datasets for Long-Range Neural Circuit Reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Hogrebe, Luke; Paiva, Antonio R.; Jurrus, Elizabeth R.; Christensen, Cameron; Bridge, Michael; Dai, Li; Pfeiffer, Rebecca; Hof, Patrick; Roysam, Badrinath; Korenberg, Julie; Tasdizen, Tolga

    2012-06-15

    In the context of long-range digital neural circuit reconstruction, this paper investigates an approach for registering axons across histological serial sections. Tracing distinctly labeled axons over large distances allows neuroscientists to study very explicit relationships between the brain's complex interconnects and, for example, diseases or aberrant development. Large scale histological analysis requires, however, that the tissue be cut into sections. In immunohistochemical studies thin sections are easily distorted due to the cutting, preparation, and slide mounting processes. In this work we target the registration of thin serial sections containing axons. Sections are first traced to extract axon centerlines, and these traces are used to define registration landmarks where they intersect section boundaries. The trace data also provides distinguishing information regarding an axon's size and orientation within a section. We propose the use of these features when pairing axons across sections in addition to utilizing the spatial relationships amongst the landmarks. The global rotation and translation of an unregistered section are accounted for using a random sample consensus (RANSAC) based technique. An iterative nonrigid refinement process using B-spline warping is then used to reconnect axons and produce the sought after connectivity information.

  9. On serial observation processing in localized ensemble Kalman filters

    OpenAIRE

    Nerger, Lars

    2015-01-01

    Ensemble square root filters can either assimilate all observations that are available at a given time at once, or assimilate the observations in batches or one at a time. For large-scale models, the filters are typically applied with a localized analysis step. This study demonstrates that the interaction of serial observation processing and localization can destabilize the analysis process and examines under which conditions the instability becomes significant. The instabil...

  10. Oil-free hyaluronic acid matrix for serial femtosecond crystallography

    Science.gov (United States)

    Sugahara, Michihiro; Song, Changyong; Suzuki, Mamoru; Masuda, Tetsuya; Inoue, Shigeyuki; Nakane, Takanori; Yumoto, Fumiaki; Nango, Eriko; Tanaka, Rie; Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi; Hatsui, Takaki; Yabashi, Makina; Nureki, Osamu; Numata, Keiji; Iwata, So

    2016-04-01

    The grease matrix was originally introduced as a microcrystal-carrier for serial femtosecond crystallography and has been expanded to applications for various types of proteins, including membrane proteins. However, the grease-based matrix has limited application for oil-sensitive proteins. Here we introduce a grease-free, water-based hyaluronic acid matrix. Applications for proteinase K and lysozyme proteins were able to produce electron density maps at 2.3-Å resolution.

  11. Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.

    Science.gov (United States)

    Weierstall, Uwe; James, Daniel; Wang, Chong; White, Thomas A; Wang, Dingjie; Liu, Wei; Spence, John C H; Bruce Doak, R; Nelson, Garrett; Fromme, Petra; Fromme, Raimund; Grotjohann, Ingo; Kupitz, Christopher; Zatsepin, Nadia A; Liu, Haiguang; Basu, Shibom; Wacker, Daniel; Han, Gye Won; Katritch, Vsevolod; Boutet, Sébastien; Messerschmidt, Marc; Williams, Garth J; Koglin, Jason E; Marvin Seibert, M; Klinker, Markus; Gati, Cornelius; Shoeman, Robert L; Barty, Anton; Chapman, Henry N; Kirian, Richard A; Beyerlein, Kenneth R; Stevens, Raymond C; Li, Dianfan; Shah, Syed T A; Howe, Nicole; Caffrey, Martin; Cherezov, Vadim

    2014-01-01

    Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography. Data collected from sub-10-μm-sized crystals produced with less than 0.5 mg of purified protein yield structural insights regarding cyclopamine binding to the Smoothened receptor.

  12. Dynamic Trajectory Generation for Serial Elastic Actuated Robots

    OpenAIRE

    Petit, Florian; Lakatos, Dominic; Friedl, Werner; Albu-Schäffer, Alin

    2012-01-01

    Robotic systems can benefit from the introduction of properly chosen joint elasticity. Besides their robustness against rigid impact, the energy saving capabilities may increase the system dynamics. In this paper, a method applicable for robots with serial elastic joints is presented, which embodies a desired oscillatory behavior into the hardware and thereby leads to improved performance. This is achieved by shaping the flexible joint robot as a linear onemode system and embodying the nat...

  13. Experiences Implementing Efficient Java Thread Serialization, Mobility and Persistence

    OpenAIRE

    Bouchenak, Sara; Hagimont, Daniel; Krakowiak, Sacha; De Palma, Noel; Boyer, Fabienne

    2002-01-01

    Today, mobility and persistence are important aspects of distributed computing- . They have many fields of use such as load balancing, fault tolerance and dynamic reconfiguration of applications. In this context, Java provides many useful mechanisms for the mobility of code via dynamic class loading, and the mobility or persistence of data via object serialization. However, Java does not provide any mechanism for the mobility/persistence of computation (i.e., threads). We designed and impleme...

  14. Serial Analysis of Gene Expression: Applications in Human Studies

    OpenAIRE

    2004-01-01

    Serial analysis of gene expression (SAGE) is a powerful tool, which provides quantitative and comprehensive expression profile of genes in a given cell population. It works by isolating short fragments of genetic information from the expressed genes that are present in the cell being studied. These short sequences, called SAGE tags, are linked together for efficient sequencing. The frequency of each SAGE tag in the cloned multimers directly reflects the transcript abundance. Therefore, SAGE r...

  15. Which serial killers commit suicide? An exploratory study.

    Science.gov (United States)

    Lester, David; White, John

    2012-11-30

    In a sample of 483 serial killers, 6.2% were documented to have committed suicide. Those who committed suicide were found to come from more dysfunctional homes characterized by more psychiatric disturbance in the parents. The sexual acts involved in the murders by the suicides seemed to be more deviant in some aspects, such as committing more bizarre sexual acts or more often taping the murder.

  16. Une reconstruction éliasienne de la théorie d'Alexander Wendt : pour une approche relationniste de la politique internationale

    OpenAIRE

    Lacassagne, Aurélie

    2008-01-01

    520 p.; This thesis proposes a critical deconstruction of Alexander Wendt's theory. We underline the genealogy of his thought in the contexts of social theory and international relations theory.Thus, we can say that the Wendtian theory does not solve the agency-structure problem, but actually emphasizes the very terminological problem of this debate. In particular, Wendt's will to synthesize two co-determinist approaches – critical realism and constructivism – shows the deadlock of such a thi...

  17. Serial extraction: 20 years of follow-up.

    Science.gov (United States)

    Almeida, Renato Rodrigues de; Almeida, Marcio Rodrigues de; Oltramari-Navarro, Paula Vanessa Pedron; Conti, Ana Cláudia de Castro Ferreira; Navarro, Ricardo de Lima; Souza, Karen Regina Siqueira de

    2012-01-01

    This paper reports a case treated by a serial extraction program at the mixed dentition stage followed by a corrective orthodontic treatment, with a long-term follow-up period. Twenty years after the interceptive treatment, a harmonious face was observed along with treatment stability in the anterior posterior direction, deep overbite (which has been mentioned as a disadvantage of the serial extraction program), and a small relapse of anterior tooth crowding. All these conditions have been regarded as normal occurrences for most orthodontic treatments with a long-term follow-up period. This case report demonstrated that the establishment of a serial extraction protocol determined relevant esthetic changes that afforded an improvement of the patient's self-esteem, with a positive social impact. Furthermore, the low cost of this protocol permits the use of this therapy with underprivileged populations. It is important to emphasize that an early correction of tooth crowding by this protocol does not guarantee stability, but small relapses do not invalidate its accomplishment.

  18. Serial extraction: 20 years of follow-up

    Directory of Open Access Journals (Sweden)

    Renato Rodrigues de Almeida

    2012-08-01

    Full Text Available This paper reports a case treated by a serial extraction program at the mixed dentition stage followed by a corrective orthodontic treatment, with a long-term follow-up period. Twenty years after the interceptive treatment, a harmonious face was observed along with treatment stability in the anterior posterior direction, deep overbite (which has been mentioned as a disadvantage of the serial extraction program, and a small relapse of anterior tooth crowding. All these conditions have been regarded as normal occurrences for most orthodontic treatments with a long-term follow-up period. This case report demonstrated that the establishment of a serial extraction protocol determined relevant esthetic changes that afforded an improvement of the patient's self-esteem, with a positive social impact. Furthermore, the low cost of this protocol permits the use of this therapy with underprivileged populations. It is important to emphasize that an early correction of tooth crowding by this protocol does not guarantee stability, but small relapses do not invalidate its accomplishment.

  19. Voltage balancing strategies for serial connection of microbial fuel cells

    Science.gov (United States)

    Khaled, Firas; Ondel, Olivier; Allard, Bruno; Buret, François

    2015-07-01

    The microbial fuel cell (MFC) converts electrochemically organic matter into electricity by means of metabolisms of bacteria. The MFC power output is limited by low voltage and low current characteristics in the range of microwatts or milliwatts per litre. In order to produce a sufficient voltage level (>1.5 V) and sufficient power to supply real applications such as autonomous sensors, it is necessary to either scale-up one single unit or to connect multiple units together. Many topologies of connection are possible as the serial association to improve the output voltage, or the parallel connection to improve the output current or the series/parallel connection to step-up both voltage and current. The association of MFCs in series is a solution to increase the voltage to an acceptable value and to mutualize the unit's output power. The serial association of a large number of MFCs presents several issues. The first one is the hydraulic coupling among MFCs when they share the same substrate. The second one is the dispersion between generators that lead to a non-optimal stack efficiency because the maximum power point (MPP) operation of all MFCs is not permitted. Voltage balancing is a solution to compensate non-uniformities towards MPP. This paper presents solutions to improve the efficiency of a stack of serially connected MFCs through a voltage-balancing circuit. Contribution to the topical issue "Electrical Engineering Symposium (SGE 2014)", edited by Adel Razek

  20. Cognitive, emotional and social markers of serial murdering.

    Science.gov (United States)

    Angrilli, Alessandro; Sartori, Giuseppe; Donzella, Giovanna

    2013-01-01

    Although criminal psychopathy is starting to be relatively well described, our knowledge of the characteristics and scientific markers of serial murdering is still very poor. A serial killer who murdered more than five people, KT, was administered a battery of standardized tests aimed at measuring neuropsychological impairment and social/emotional cognition deficits. KT exhibited a striking dissociation between a high level of emotional detachment and a low score on the antisocial behavior scale on the Psychopathy Checklist-Revised (PCL-R). The Minnesota Multiphasic Personality Inventory-2 showed a normal pattern with the psychotic triad at borderline level. KT had a high intelligence score and showed almost no impairment in cognitive tests sensitive to frontal lobe dysfunction (Wisconsin Card Sorting Test, Theory of Mind, Tower of London, this latter evidenced a mild impairment in planning performance). In the tests on moral, emotional and social cognition, his patterns of response differed from matched controls and from past reports on criminal psychopaths as, unlike these individuals, KT exhibited normal recognition of fear and a relatively intact knowledge of moral rules but he was impaired in the recognition of anger, embarrassment and conventional social rules. The overall picture of KT suggests that serial killing may be closer to normality than psychopathy defined according to either the DSM IV or the PCL-R, and it would be characterized by a relatively spared moral cognition and selective deficits in social and emotional cognition domains.

  1. Orientation angle workspaces of planar serial three-link manipulators

    Institute of Scientific and Technical Information of China (English)

    DAI; Jian; S

    2009-01-01

    This paper presents a classification on the workspaces of planar serial three-link manipulators, that is, position workspace and orientation angle workspace. Position workspace indicates the region reached by the reference point on the end-effector. Orientation angle workspace indicates a set of angle ranges by which the end-effector can reach with certain orientation for every point in the reachable position workspace. By introducing a virtual equivalent mechanism, reachable position workspace can be di- vided into several Grashof intervals and non-Grashof intervals. The calculation equations of orientation angle workspace are deduced in three situations according to the relationships among four link lengths in the virtual four-bar chain. Three examples are given for three kinds of relationship of link lengths. The orientation angle workspace of extended groups, that is, two of the three link lengths equal, and the orientation angle workspace when the reference point on the end-effector moves along a non-radial direction are also discussed. A program is developed to calculate orientation angle workspaces and output variation curves of orientation angle workspace and key data within the position workspace. The approach and program in this paper can be used for fast calculation and identification of the variation rule of the orientation angle workspace of any given planar serial three-link manipulator on the basis of its link parameters, and for the design of a highly dexterous serial manipulator with proposed link rela- tions.

  2. Orientation angle workspaces of planar serial three-link manipulators

    Institute of Scientific and Technical Information of China (English)

    LI RuiQin; DAI Jian S

    2009-01-01

    This paper presents a classification on the workspaces of planar serial three-link manipulators, that is,position workspace and orientation angle workspace. Position workspace indicates the region reached by the reference point on the end-effector. Orientation angle workspace indicates a set of angle ranges by which the end-effector can reach with certain orientation for every point in the reachable position workspace. By introducing a virtual equivalent mechanism, reachable position workspace can be divided into several Grashof intervals and non-Grashof intervals. The calculation equations of orientation angle workspace are deduced in three situations according to the relationships among four link lengths in the virtual four-bar chain. Three examples are given for three kinds of relationship of link lengths.The orientation angle workspace of extended groups, that is, two of the three link lengths equal, end the orientation angle workspace when the reference point on the end-effector moves along a non-radial direction are also discussed. A program is developed to calculate orientation angle workspaces and output variation curves of orientation angle workspace and key data within the position workspace. The approach and program in this paper can be used for fast calculation and identification of the variation rule of the orientation angle workspace of any given planar serial three-link manipulator on the basis of its link parameters, and for the design of a highly dexterous serial manipulator with proposed link relations.

  3. Serial pixel analog-to-digital converter (ADC)

    Science.gov (United States)

    Larson, Eric D.

    2010-02-01

    This method reduces the data path from the counter to the pixel register of the analog-to-digital converter (ADC) from as many as 10 bits to a single bit. The reduction in data path width is accomplished by using a coded serial data stream similar to a pseudo random number (PRN) generator. The resulting encoded pixel data is then decoded into a standard hexadecimal format before storage. The high-speed serial pixel ADC concept is based on the single-slope integrating pixel ADC architecture. Previous work has described a massively parallel pixel readout of a similar architecture. The serial ADC connection is similar to the state-of-the art method with the exception that the pixel ADC register is a shift register and the data path is a single bit. A state-of-the-art individual-pixel ADC uses a single-slope charge integration converter architecture with integral registers and "one-hot" counters. This implies that parallel data bits are routed among the counter and the individual on-chip pixel ADC registers. The data path bit-width to the pixel is therefore equivalent to the pixel ADC bit resolution.

  4. Comparative Analysis of Serial Decision Tree Classification Algorithms

    Directory of Open Access Journals (Sweden)

    Matthew Nwokejizie Anyanwu

    2009-09-01

    Full Text Available Classification of data objects based on a predefined knowledge of the objects is a data mining and knowledge management technique used in grouping similar data objects together. It can be defined as supervised learning algorithms as it assigns class labels to data objects based on the relationship between the data items with a pre-defined class label. Classification algorithms have a wide range of applications like churn prediction, fraud detection, artificial intelligence, and credit card rating etc. Also there are many classification algorithms available in literature but decision trees is the most commonly used because of its ease of implementation and easier to understand compared to other classification algorithms. Decision Tree classification algorithm can be implemented in a serial or parallel fashion based on the volume of data, memory space available on the computer resource and scalability of the algorithm. In this paper we will review the serial implementations of the decision tree algorithms, identify those that are commonly used. We will also use experimental analysis based on sample data records (Statlog data sets to evaluate the performance of the commonly used serial decision tree algorithms

  5. SOAP Serialization Performance Enhancement, Design And Implementation Of A Middleware

    CERN Document Server

    Minaei, Behrouz

    2009-01-01

    The most straightforward way to improve performance of any system is to define the bottlenecks and think of ways to remove them. Web services are the inseparable part of any web application, as a result enhancing performance of web services will have a great effect on the overall performance of the system. The most widely used communication protocol in the web services model, SOAP, is a simple protocol for the exchange of messages. The serialization of large SOAP responses is a major performance bottleneck in a SOAP message exchange. Clearly, some web servers can expect to receive many similar messages for a particular web service as they share the same signature. The idea behind this paper is to avoid the redundant serialization stage of SOAP responses for request which have the same call parameters. The technique exploits the similarities between call parameters to improve web service Response Time by avoiding redundant serialization of the same response with the help of a middleware running on top of web s...

  6. Listening to the whispers of matter through Arabic hermeticism: new studies on The Book of the Treasure of Alexander.

    Science.gov (United States)

    Alfonso-Goldfarb, Ana Maria; Jubran, Safa Abou Chahla

    2008-07-01

    The Jabirian Corpus refers to the K. Thahirat Al-'Iskandar, "The Book of the Treasure of Alexander" (hereafter BTA), as one of several forgeries suggesting that alchemical secrets were hidden in inscriptions in various places. The book was neglected until 1926, when Julius Ruska discussed it in his work on the Emerald Tablet, placing the BTA within the literature related to the development of Arabic alchemy. His preliminary study became an essential reference and encouraged many scholars to work on the BTA in the following decades. Some years ago, we completed the first translation of the BTA into a Western language. The work was based on the acephalous Escorial manuscript, which we identified as a fourteenth-century copy of the BTA. This manuscript is peculiar, as part of it is encoded. After finishing our translation, we started to establish the text of the BTA. At present, the text is in process of fixation--to be followed by textual criticism--and has been the main focus of a thorough study of ours on medieval hermeticism and alchemy. A sample of the work currently in progress is presented in this paper: an analysis of the variations between different manuscripts along with a study and English translation of its alchemical chapter.

  7. Alexander von Humboldt: galvanism, animal electricity, and self-experimentation part 1: formative years, naturphilosophie, and galvanism.

    Science.gov (United States)

    Finger, Stanley; Piccolino, Marco; Stahnisch, Frank W

    2013-01-01

    During the 1790s, Alexander von Humboldt (1769-1859), who showed an early interest in many facets of natural philosophy and natural history, delved into the controversial subject of galvanism and animal electricity, hoping to shed light on the basic nature of the nerve force. He was motivated by his broad worldview, the experiments of Luigi Galvani, who favored animal electricity in more than a few specialized fishes, and the thinking of Alessandro Volta, who accepted specialized fish electricity but was not willing to generalize to other animals, thinking Galvani's frog experiments flawed by his use of metals. Differing from many German Naturphilosophen, who shunned "violent" experiments, the newest instruments, and detailed measurement, Humboldt conducted thousands of galvanic experiments on animals and animal parts, as well as many on his own body, some of which caused him great pain. He interpreted his results as supporting some but not all of the claims made by both Galvani and Volta. Notably, because of certain negative findings and phenomenological differences, he remained skeptical about the intrinsic animal force being qualitatively identical to true electricity. Hence, he referred to a "galvanic force," not animal electricity, in his letters and publications, a theoretical position he would abandon with Volta's help early in the new century.

  8. Two Exceptional Witnesses of Latin American Independence: The Prussian Explorer Alexander Von Humboldt and The Virginian Politician Thomas Jefferson

    Directory of Open Access Journals (Sweden)

    Sandra Rebok

    2014-01-01

    Full Text Available Este artículo analiza las respectivas posturas de Alexander von Humboldt y Thomas Jefferson en relación con la independencia de los territorios hispanoamericanos y el modo en que estas se hallaban condicionadas por sus propias experiencias: Humboldt, como observador de la situación americana justo antes del comienzo de los movimientos independentistas; y Jefferson, como actor importante en la independencia de los EE.UU. y la posterior creación de una nueva sociedad. Asimismo, no se pueden estudiar sus respectivas posiciones hacia los movimientos independentistas en la América española, desvinculadas de sus conclusiones respecto a la Revolución francesa y sus consecuencias. El trabajo muestra de qué manera los dos personajes comentaron estos sucesos en la correspondencia que mantuvieron entre sí. Finalmente, también se evalúan, a través de estos famosos representantes del llamado Nuevo Mundo y el Viejo Mundo, las diferencias y similitudes en la manera de reaccionar ante estos eventos políticos y sociales desde el punto de vista europeo, en comparación con la mirada desde Norteamérica.

  9. Growing community: the impact of the Stephanie Alexander Kitchen Garden Program on the social and learning environment in primary schools.

    Science.gov (United States)

    Block, Karen; Gibbs, Lisa; Staiger, Petra K; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

    2012-08-01

    This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has a positive impact on student engagement, social connections, and confidence within and beyond the school gates. Primary evidence for the research question came from qualitative data collected from students, parents, teachers, volunteers, school principals, and specialist staff through interviews, focus groups, and participant observations. This was supported by analyses of quantitative data on child quality of life, cooperative behaviors, teacher perceptions of the school environment, and school-level educational outcome and absenteeism data. Results showed that some of the program attributes valued most highly by study participants included increased student engagement and confidence, opportunities for experiential and integrated learning, teamwork, building social skills, and connections and links between schools and their communities. In this analysis, quantitative findings failed to support findings from the primary analysis. Limitations as well as benefits of a mixed-methods approach to evaluation of complex community interventions are discussed.

  10. Comparison of SUV and Patlak slope for monitoring of cancer therapy using serial PET scans

    Energy Technology Data Exchange (ETDEWEB)

    Freedman, Nanette M.T. [Hadassah University Hospital, Jerusalem (Israel); Sundaram, Senthil K.; Kurdziel, Karen; Carrasquillo, Jorge A.; Whatley, Millie; Carson, Joann M.; Sellers, David; Libutti, Steven K.; Yang, James C.; Bacharach, Stephen L. [National Institutes of Health, Bethesda, MD (United States)

    2003-01-01

    The standardized uptake value (SUV) and the slope of the Patlak plot (K) have both been proposed as indices to monitor the progress of disease during cancer therapy. Although a good correlation has been reported between SUV and K, they are not equivalent, and may not be equally affected by metabolic changes occurring during disease progression or therapy. We wished to compare changes in tumor SUV with changes in K during serial positron emission tomography (PET) scans for monitoring therapy. Thirteen patients enrolled in a protocol to treat renal cell carcinoma metastases were studied. Serial dynamic fluorodeoxyglucose (FDG) PET scans and computed tomography (CT) and magnetic resonance (MR) scans were performed once prior to treatment, once at 36{+-}2 days after the start of treatment, and (in 7/13 subjects, 16/27 lesions) a third time at 92{+-}9 days after the start of treatment. This resulted in a total of 33 scans, and 70 tumor Patlak and SUV values (one value for each lesion at each time point). SUV and K were measured over one to four predefined tumors/patient at each time point. The input function was obtained from regions of interest over the heart, combined, if necessary, with late blood samples. Over all tumors and scans, SUV and K correlated well (r=0.97, P<0.0001). However, change in SUV with treatment over all tumor scan pairs was much less well correlated with the corresponding change in K (r=0.73, P<0.0001). The absolute difference in % change was outside the 95% confidence limits expected from previous variability studies in 6 of 43 pairs of tumor scans, and greater than 50% in 2 of 43 tumor scan pairs. In four of the six cases, the two indices predicted opposing therapeutic outcomes. Similar results were obtained for SUV normalized by body weight or body surface area and for SUVs using mean or maximum count. Changes in CT and MR tumor cross-product dimensions correlated poorly with each other (r=0.47, P=NS), and so could not be used to determine the

  11. Applying social learning theory to childhood and adolescent firesetting: can it lead to serial murder?

    Science.gov (United States)

    Singer, Stephen D; Hensley, Christopher

    2004-08-01

    Despite the fact that serial murder has existed for centuries, it has been given little academic attention in the social science literature. Existing studies have primarily examined the motivational factors involved in the commission of serial murder. However, research examining the childhood and adolescent backgrounds of serial murderers is scant. Based on three case studies of serial murderers, this study contributes to the existing literature by exploring the possible link between childhood and/or adolescent fire setting and adult serial murder by applying social learning theory.

  12. Serial measurements of serum human placental lactogen (hPL) and serial ultrasound examinations in the evaluation of fetal growth

    DEFF Research Database (Denmark)

    Sørensen, Steen; von Tabouillot, D; Schioler, V;

    2000-01-01

    weakly to intrauterine growth velocity (r=0.08). hPL-slope and intrauterine growth velocity independently predicted birth weight deviation. Heavy smoking which was stopped before the third trimester was not associated with low intrauterine growth velocity, but with a low hPL-slope. Preeclampsia...... and to the deviation in birth weight, but hPL seems to have a separate physiological significance, since it did not pick up when smoking was stopped and growth velocity was normalised and it did not at all detect the increased growth associated with preeclampsia.......Serial serum hPL measurements and serial ultrasound fetometry were compared in the evaluation of fetal growth by relating these two parameters to size at birth and to clinical factors known to influence size at birth. The data were from a prospective study of 1000 consecutive pregnant women...

  13. Serial measurements of exercise performance in pediatric heart transplant patients using stress echocardiography.

    Science.gov (United States)

    Yeung, Joanne P; Human, Derek G; Sandor, George G S; De Souza, Astrid M; Potts, James E

    2011-05-01

    Heart transplantation is an increasingly acceptable therapeutic option for children with end-stage and complex congenital heart disease. With advances in surgery, immunosuppression, and follow-up care, functional outcomes need to be evaluated. We report the results of serial exercise testing performed using stress echocardiography in a cohort of pediatric HTP. HTP (n = 7) exercised on a semi-recumbent ergometer to volitional fatigue. Echocardiography-Doppler measurements, HR, and blood pressure were taken at rest and during staged exercise. Results were compared with healthy CON (n = 12). HTP did significantly less work during exercise (940 vs. 1218 J/kg, p HTP had a lower SF at peak exercise (48% vs. 52%, p HTP. HTP are able to exercise safely; however, their exercise tolerance is reduced, and hemodynamics and contractility are diminished. Over time, their hemodynamics and left ventricular function have remained relatively constant.

  14. Role of serial multiparametric magnetic resonance imaging in prostate cancer active surveillance

    Institute of Scientific and Technical Information of China (English)

    Larissa J Vos; Michele Janoski; Keith Wachowicz; Atiyah Yahya; Oleksandr Boychak; John Amanie; Nadeem Pervez; Matthew B Parliament; Edith Pituskin; B Gino Fallone; Nawaid Usmani

    2016-01-01

    AIM:To examine whether addition of 3T multiparametric magnetic resonance imaging(mp MRI)to an active surveillance protocol could detect aggressive or progressive prostate cancer.METHODS:Twenty-three patients with low risk disease were enrolled on this active surveillance study,all of which had Gleason score 6 or less disease.All patients had clinical assessments,including digital rectal examination and prostate specific antigen(PSA)testing,every 6 mo with annual 3T mp MRI scans with gadolinium contrast and minimum sextant prostate biopsies.The MRI images were anonymized of patient identifiers and clinical information and each scan underwentradiological review without the other results known.Descriptive statistics for demographics and follow-up as well as the sensitivity and specificity of mp MRI to identify prostate cancer and progressive disease were calculated.RESULTS:During follow-up(median 24.8 mo)11 of 23 patients with low-risk prostate cancer had disease progression and were taken off study to receive definitive treatment.Disease progression was identified through upstaging of Gleason score on subsequent biopsies for all 11 patients with only 2 patients also having a PSA doubling time of less than 2 years.All 23 patients had biopsy confirmed prostate cancer but only 10 had a positive index of suspicion on mp MRI scans at baseline(43.5% sensitivity).Aggressive disease prediction from baseline mpM RI scans had satisfactory specificity(81.8%)but low sensitivity(58.3%).Twentytwo patients had serial mp MRI scans and evidence of disease progression was seen for 3 patients all of whom had upstaging of Gleason score on biopsy(30% specificity and 100% sensitivity).CONCLUSION:Addition of mp MRI imaging in active surveillance decision making may help in identifying aggressive disease amongst men with indolent prostate cancer earlier than traditional methods.

  15. The essential guide to Serial ATA and SATA express

    CERN Document Server

    Deming, David A

    2014-01-01

    Used in laptop and desktop computers, low-end servers, and mobile devices, Serial ATA (Advance Technology Attachment), or SATA, is the pervasive disk storage technology in use today. SATA has also penetrated the enterprise computing environment by adding hardware components for fail-over, extending command processing capabilities, and increasing device performance and link speeds. If you work in a data center or manage your company's storage resources, you will likely encounter storage solutions that require SATA software or hardware.In this book, leading storage networking technologist David

  16. Serial Cost Sharing with Many Goods and General Aggregation

    OpenAIRE

    2000-01-01

    The Serial Cost Sharing Rule has been conceived originally for problems where agents ask for different quantities of an homogeneous private good, the sum of which is produced by a single facility. In this context, it is endowed with a variety of desirable equity and coherency properties. This paper investigates the extension of this rule to the context where agents ask many goods that may be specific to some of them and where the aggregation rule may be very general. It begins with a systemat...

  17. POSSIBILITIES OF INCREASING EFFICIENCY WITHIN SERIAL PRODUCTION MANAGEMENT

    Directory of Open Access Journals (Sweden)

    CODRUŢA DURA

    2010-01-01

    Full Text Available Under the impact of transition to the new post-industrial society, massproduction recently faced the most numerous difficulties. They are caused by turbulences in theexternal environment in which companies operate, manifested in particular by enhancing thedynamism of markets and by deep changes in the structure of consumers’ demands. In thiscontext, specialized literature records the concerns for increasing the efficiency and flexibilityof products, elements involving radical changes of management and manufacturingtechnologies methods. Given these issues, the paper approaches two separate ways to improvethe management of serial production: increasing economic efficiency by optimizing the size ofbatches and flexible production systems by implementing techniques to reduce the change-overtime.

  18. Word-serial Architectures for Filtering and Variable Rate Decimation

    Directory of Open Access Journals (Sweden)

    Eugene Grayver

    2002-01-01

    Full Text Available A new flexible architecture is proposed for word-serial filtering and variable rate decimation/interpolation. The architecture is targeted for low power applications requiring medium to low data rate and is ideally suited for implementation on either an ASIC or an FPGA. It combines the small size and low power of an ASIC with the programmability and flexibility of a DSP. An efficient memory addressing scheme eliminates the need for power hungry shift registers and allows full reconfiguration. The decimation ratio, filter length and filter coefficients can all be changed in real time. The architecture takes advantage of coefficient symmetries in linear phase filters and in polyphase components.

  19. High-resolution protein structure determination by serial femtosecond crystallography.

    Science.gov (United States)

    Boutet, Sébastien; Lomb, Lukas; Williams, Garth J; Barends, Thomas R M; Aquila, Andrew; Doak, R Bruce; Weierstall, Uwe; DePonte, Daniel P; Steinbrener, Jan; Shoeman, Robert L; Messerschmidt, Marc; Barty, Anton; White, Thomas A; Kassemeyer, Stephan; Kirian, Richard A; Seibert, M Marvin; Montanez, Paul A; Kenney, Chris; Herbst, Ryan; Hart, Philip; Pines, Jack; Haller, Gunther; Gruner, Sol M; Philipp, Hugh T; Tate, Mark W; Hromalik, Marianne; Koerner, Lucas J; van Bakel, Niels; Morse, John; Ghonsalves, Wilfred; Arnlund, David; Bogan, Michael J; Caleman, Carl; Fromme, Raimund; Hampton, Christina Y; Hunter, Mark S; Johansson, Linda C; Katona, Gergely; Kupitz, Christopher; Liang, Mengning; Martin, Andrew V; Nass, Karol; Redecke, Lars; Stellato, Francesco; Timneanu, Nicusor; Wang, Dingjie; Zatsepin, Nadia A; Schafer, Donald; Defever, James; Neutze, Richard; Fromme, Petra; Spence, John C H; Chapman, Henry N; Schlichting, Ilme

    2012-07-20

    Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding radiation damage. We applied serial femtosecond crystallography (SFX) using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals (less than 1 micrometer by 1 micrometer by 3 micrometers) of the well-characterized model protein lysozyme. The agreement with synchrotron data demonstrates the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules.

  20. SERIAL SECTIONS THROUGH A CONTINUOUS FIBER-REINFORCED POLYMER COMPOSITE

    Directory of Open Access Journals (Sweden)

    Laurent Bizet

    2011-05-01

    Full Text Available The microstructure of a unidirectional glass-fiber composite material is described seeking especially for the influence of the stitching perpendicular to the reinforcement. Serial cuts are performed through the composite and the microstructure is quantified using global parameters and linear morphological analysis. A key result is that the stitching induces variations in fibers spacing within the yarns and in the matrix volume between the yarns. This can affect noticeably the flow of the resin during the manufacturing process and also the mechanical properties of the composite.

  1. Serial rapists and their victims: reenactment and repetition.

    Science.gov (United States)

    Burgess, A W; Hazelwood, R R; Rokous, F E; Hartman, C R; Burgess, A G

    1988-01-01

    The major finding in this study of 41 serial rapists is the large numbers of reported and unreported victims. For over 1200 attempted and completed rapes, there were 200 convictions. The hidden rapes or earliest nonreported victims of these men as boys and adolescents were identified from their families, their neighborhood, and their schools. Examining the possible link between childhood sexual abuse and criminal behavior in this sample of 41 serial rapists, 56.1% were judged to have at least one forced or exploitive abuse experience in boyhood, as compared to a study of 2,972 college males reporting 7.3% experiencing boyhood sexual abuse. Looking within the abused samples, 56.1% of the rapists reported forced sex, compared to the college sample's 30.4%. Also, the rapist sample revealed higher rates of family member as abuser (48.4%), compared to 22.2% for the college sample. Retrospective reconstruction of the sexual activities and assertive behaviors of these men as boys reveals that 51% of the boys reenact the abuse as a preadolescent with their earliest victims being known to them (48% as neighborhood girls), family (25% as sisters), or girlfriend (25%). The onset of rape fantasies in midadolescence (mean age 16.9) crystalizes the earlier sexually initiated behaviors into juvenile behaviors of spying, fetish burglaries, molestations, and rapes. Repetition of these juvenile behaviors set their criminal patters on strangers--their next group of victims. To reduce victimization, serial rapists need to be identified early and stopped. This means acknowledging and reporting boy sexual abuse. This includes being sensitive to the reenactment behaviors noted in the initiated activities of abused children, which in turn need to be differentiated from peer play. Closer attention needs to be paid to families with incest behavior to insure that younger children are protected. Adolescents showing early repetitive juvenile delinquent behaviors must be assessed for physical

  2. 日立全新Serial ATA硬盘

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    日立环球存储科技公司推出全新ATA/Serial ATA台式机硬盘。日立Deskstar 7K250的3.5英寸硬盘通过80GB以上的单碟容量科技能提供达四分之一Terabyte的容量(Iterabyte为1000GB;1/4terabyte即250GB)。日立全新7200RPM硬盘专为传统台式设计,

  3. Lean buffering in serial production lines with Bernoulli machines

    Directory of Open Access Journals (Sweden)

    A. B. Hu

    2006-01-01

    Full Text Available Lean buffering is the smallest buffer capacity necessary to ensure the desired production rate of a manufacturing system. In this paper, analytical methods for selecting lean buffering in serial production lines are developed under the assumption that the machines obey the Bernoulli reliability model. Both closed-form expressions and recursive approaches are investigated. The cases of identical and nonidentical machines are analyzed. Results obtained can be useful for production line designers and production managers to maintain the required production rate with the smallest possible inventories.

  4. Geosciences Information for Teachers (GIFT) Workshops held in Conjunction with Alexander von Humboldt (AvH) EGU Conferences

    Science.gov (United States)

    Laj, Carlo; Cifelli, Francesca

    2015-04-01

    The Alexander von Humboldt Conference Series of the European Geosciences Union are a series of meetings held outside of Europe, in particular in South America, Africa or Asia, on selected topics of geosciences with a socio-economic impact for regions on these continents, jointly organised with the scientists and their institutes and the institutions of these regions. Given the increasing success of the GIFT workshops held in conjunction with the General Assemblies, since 2010 EGU has also developed a series of GIFT workshops held in conjunction with AvH conferences. Associated GIFT workshops were held in Merida, Yucatan, on the theme of Climate Change, Natural Hazards and Societies (March 2010), then in Penang, Malaysia (June 2011) on the theme of Ocean Acidification, in November 2012 in Cusco (Peru) on the theme of Natural Disasters, Global Change and the Preservation of World Heritage Sites, finally in Istanbul (March 2014) on "High Impact Natural Hazards Related to the Euro-Mediterranean Region. The next GIFT workshop is already planned for October 2015 in Adis Ababa (Ethiopia) on the theme "Water". In each case, the GIFT workshop was held on the last two days of the AvH conference and reunited 40-45 teachers from the nation where the AvH was held. Keynote speakers from AvH were speakers to the GIFT workshops which also included hands-on activities animated by sciences educators. These GIFT workshops represented the first workshops specifically aimed at teachers held in the country, and therefore represents a significant Earth Sciences contribution to secondary education in non European countries.

  5. Alexander von Humboldt: galvanism, animal electricity, and self-experimentation part 2: the electric eel, animal electricity, and later years.

    Science.gov (United States)

    Finger, Stanley; Piccolino, Marco; Stahnisch, Frank W

    2013-01-01

    After extensive experimentation during the 1790s, Alexander von Humboldt remained skeptical about "animal electricity" (and metallic electricity), writing instead about an ill-defined galvanic force. With his worldview and wishing to learn more, he studied electric eels in South America just as the new century began, again using his body as a scientific instrument in many of his experiments. As had been the case in the past and for many of the same reasons, some of his findings with the electric eel (and soon after, Italian torpedoes) seemed to argue against biological electricity. But he no longer used galvanic terminology when describing his electric fish experiments. The fact that he now wrote about animal electricity rather than a different "galvanic" force owed much to Alessandro Volta, who had come forth with his "pile" (battery) for multipling the physical and perceptable effects of otherwise weak electricity in 1800, while Humboldt was deep in South America. Humboldt probably read about and saw voltaic batteries in the United States in 1804, but the time he spent with Volta in 1805 was probably more significant in his conversion from a galvanic to an electrical framework for understanding nerve and muscle physiology. Although he did not continue his animal electricity research program after this time, Humboldt retained his worldview of a unified nature and continued to believe in intrinsic animal electricity. He also served as a patron to some of the most important figures in the new field of electrophysiology (e.g., Hermann Helmholtz and Emil du Bois-Reymond), helping to take the research that he had participated in to the next level.

  6. DISEASES

    DEFF Research Database (Denmark)

    Pletscher-Frankild, Sune; Pallejà, Albert; Tsafou, Kalliopi;

    2015-01-01

    Text mining is a flexible technology that can be applied to numerous different tasks in biology and medicine. We present a system for extracting disease-gene associations from biomedical abstracts. The system consists of a highly efficient dictionary-based tagger for named entity recognition...... of human genes and diseases, which we combine with a scoring scheme that takes into account co-occurrences both within and between sentences. We show that this approach is able to extract half of all manually curated associations with a false positive rate of only 0.16%. Nonetheless, text mining should...... not stand alone, but be combined with other types of evidence. For this reason, we have developed the DISEASES resource, which integrates the results from text mining with manually curated disease-gene associations, cancer mutation data, and genome-wide association studies from existing databases...

  7. Serial crystallography on in vivo grown microcrystals using synchrotron radiation

    Directory of Open Access Journals (Sweden)

    Cornelius Gati

    2014-03-01

    Full Text Available Crystal structure determinations of biological macromolecules are limited by the availability of sufficiently sized crystals and by the fact that crystal quality deteriorates during data collection owing to radiation damage. Exploiting a micrometre-sized X-ray beam, high-precision diffractometry and shutterless data acquisition with a pixel-array detector, a strategy for collecting data from many micrometre-sized crystals presented to an X-ray beam in a vitrified suspension is demonstrated. By combining diffraction data from 80 Trypanosoma brucei procathepsin B crystals with an average volume of 9 µm3, a complete data set to 3.0 Å resolution has been assembled. The data allowed the refinement of a structural model that is consistent with that previously obtained using free-electron laser radiation, providing mutual validation. Further improvements of the serial synchrotron crystallography technique and its combination with serial femtosecond crystallography are discussed that may allow the determination of high-resolution structures of micrometre-sized crystals.

  8. External serial connection without layer patterning for organic solar cells

    Science.gov (United States)

    Wong, Ying Qian; Wong, Hin Yong; Tan, Ching Seong; Meng, Hsin-Fei

    2016-12-01

    This paper proposes a novel alternative to conventional internal serial connection, where precise patterning and scribing of organic layers can be eliminated. Adjacent cells can be made nearer for better space-utilization and higher voltages per unit area. Also, blade coating is proposed as the fabrication method as it has low material wastage (less than 5%), easily scalable to large area, has high film uniformity and has high throughput due to its roll-to-roll potential. This paper demonstrates 3-cells large area (12.98 cm2) external serial connection organic solar cells (OSCs) using the material poly(3-hexylthiophene-2,5-diyl):[6,6]-phenyl-C61-butyric acid methyl ester (P3HT:PCBM) and 2,6-Bis(trimethyltin)-4, 8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo [1,2-b:4,5-b']dithiophene:6,6-phenyl C71-butyric acid methyl ester (PBDTTT-CT:PC71BM) respectively. The power conversion efficiencies (PCEs) of the resulting 3-cells modules are 2.0% and 4.1% respectively.

  9. Serial Contradictions. The Italian Debate on Tv Series

    Directory of Open Access Journals (Sweden)

    Daniela Cardini

    2016-06-01

    Full Text Available In the last decade the academic debate on television seriality has become lively and often quite animated, in the US as well as in Italy. The traditional hierarchic relation between cinema and television is clearly represented by the form of the most recent tv drama, whose boundaries are more and more difficult to locate. The main questions at stake seem to be the so-called “cinematic television” (Mills, 2013; Jaramillo, 2013, the umbrella definition of “quality tv” (McCabe and Akass, 2007 and its relation with the broadest concept of “complex tv” (Mittell, 2009, 2015. The essay will take into consideration these oxymorons, which are deeply rooted in the Italian tv series debate, with the aim of considering both their risks and their opportunities. A great variety of texts are grouped under the “tv series” label, but they are very different as far as content, production values and audience reactions are concerned. The academic discourse, however, only recently has tried to identify the differences between longstanding mainstream shows (such as, for instance, Grey’s Anatomy or CSI and some more recent, and supposedly “cinematic” series like True Detective or Fargo. Together with the analysis of the oxymoric nature of recent television seriality, the essay will explore the need to historicising what is proving to be one of the most dense and fruitful domains of recent television studies.

  10. Emotional and coping responses to serial killings. The Gainesville murders.

    Science.gov (United States)

    Norvell, N K; Cornell, C E; Limacher, M C

    1993-07-01

    Forensic experts have focused more on the psychological profile of a serial killer rather than on the pronounced effects on the community at large. Coping with a stressful event is thought to influence emotional states. However, little empirical understanding of this process exists. The present study examined changes in psychological factors 9 days after the occurrence of serial killings in a college community. Multivariate analyses of variance conducted on the variables of stress, anxiety, physical symptoms, and depression revealed a significant difference between the group tested after the murders and a cross-sectional cohort group. Univariate analyses revealed that the study class was significantly more depressed compared with the cohort group. The study class was also significantly more depressed compared with their own responses 1 year before the killings. For both classes, depression was significantly correlated with certain coping styles, including escape-avoidance and accept responsibility. Results have implications for certain coping behaviors (i.e., avoidant behaviors), such as that leaving the community may have been maladaptive and perhaps diverted attention from the more necessary active problem-solving behaviors (e.g., increasing security) in addition to increasing depression.

  11. Serial assessment of local peripheral vascular function after eccentric exercise.

    Science.gov (United States)

    Stacy, Mitchel R; Bladon, Kallie J; Lawrence, Jennifer L; McGlinchy, Sarah A; Scheuermann, Barry W

    2013-12-01

    Muscle damage is a common response to unaccustomed eccentric exercise; however, the effects of skeletal muscle damage on local vascular function and blood flow are poorly understood. This study examined serial local vascular responses to flow-mediated (endothelial-dependent) and nitroglycerin-mediated (endothelial-independent) dilation in the brachial artery after strenuous eccentric exercise and serially assessed resting blood flow. Ten healthy males performed 50 maximal eccentric unilateral arm contractions to induce muscle damage to the biceps brachii. Changes in maximal isometric strength and vascular responses were assessed 1, 24, 48, and 96 h after exercise. Mean blood velocities and arterial diameters, measured with Doppler ultrasound, were used to calculate blood flow and shear stress (expressed as area under the curve). Eccentric exercise resulted in impaired maximal isometric strength for up to 96 h (p exercise, 9.4% ± 2.6%; 1 h after exercise, 5.1% ± 2.2%) and nitroglycerin responses (before exercise, 26.3% ± 6.5%; 1 h after exercise, 20.7% ± 4.7%) were observed in the 1 h after exercise and remained lower for 96 h (p exercise and remained impaired for 48 h (p eccentric exercise leads to impaired local endothelial and vascular smooth muscle function. Lower shear stress after exercise might contribute to the observed reduction in flow-mediated dilation responses, but the mechanism responsible for the attenuated endothelial-independent vasodilation remains unclear.

  12. Rethinking Conceptual Definitions of the Criminal Career and Serial Criminality.

    Science.gov (United States)

    Edelstein, Arnon

    2016-01-01

    Since Cesare Lombroso's days, criminology seeks to define, explain, and categorize the various types of criminals, their behaviors, and motives. This aim has theoretical as well as policy-related implications. One of the important areas in criminological thinking focuses chiefly on recidivist offenders who perform large numbers of crimes and/or commit the most dangerous crimes in society (rape, murder, arson, and armed robbery). These criminals have been defined as "habitual offenders," "professional criminals," "career criminals," and "serial offenders." The interest in these criminals is a rational one, given the perception that they present a severe threat to society. The main challenge in this area of research is a conceptual problem that has significant effects across the field. To this day, scholars have reused and misused titles to define and explain different concepts. The aim of this article is 3-fold. First, to review the concepts of criminal career, professional crime, habitual offenses, and seriality with a critical attitude on confusing terms. Second, to propose the redefinition of concepts mentioned previously, mainly on the criminal career. Third, to propose a theoretical model to enable a better understanding of, and serve as a basis for, further research in this important area of criminology.

  13. Stability of high cell density brewery fermentations during serial repitching.

    Science.gov (United States)

    Verbelen, Pieter J; Dekoninck, Tinne M L; Van Mulders, Sebastiaan E; Saerens, Sofie M G; Delvaux, Filip; Delvaux, Freddy R

    2009-11-01

    The volumetric productivity of the beer fermentation process can be increased by using a higher pitching rate (i.e. higher inoculum size). However, the decreased yeast net growth observed in these high cell density brewery fermentations can adversely affect the physiological stability throughout subsequent yeast generations. Therefore, different O(2) conditions (wort aeration and yeast preoxygenation) were applied to high cell density fermentation and eight generations of fermentations were evaluated together with conventional fermentations. Freshly propagated high cell density populations adapted faster to the fermentative conditions than normal cell density populations. Preoxygenating the yeast was essential for the yeast physiological and beer flavor compound stability of high cell density fermentations during serial repitching. In contrast, the use of non-preoxygenated yeast resulted in inadequate growth which caused (1) insufficient yield of biomass to repitch all eight generations, (2) a 10% decrease in viability, (3) a moderate increase of yeast age, (4) and a dramatic increase of the unwanted flavor compounds acetaldehyde and total diacetyl during the sequence of fermentations. Therefore, to achieve sustainable high cell density fermentations throughout the economical valuable process of serial repitching, adequate yeast growth is essential.

  14. Nonlinear Process Fault Diagnosis Based on Serial Principal Component Analysis.

    Science.gov (United States)

    Deng, Xiaogang; Tian, Xuemin; Chen, Sheng; Harris, Chris J

    2016-12-22

    Many industrial processes contain both linear and nonlinear parts, and kernel principal component analysis (KPCA), widely used in nonlinear process monitoring, may not offer the most effective means for dealing with these nonlinear processes. This paper proposes a new hybrid linear-nonlinear statistical modeling approach for nonlinear process monitoring by closely integrating linear principal component analysis (PCA) and nonlinear KPCA using a serial model structure, which we refer to as serial PCA (SPCA). Specifically, PCA is first applied to extract PCs as linear features, and to decompose the data into the PC subspace and residual subspace (RS). Then, KPCA is performed in the RS to extract the nonlinear PCs as nonlinear features. Two monitoring statistics are constructed for fault detection, based on both the linear and nonlinear features extracted by the proposed SPCA. To effectively perform fault identification after a fault is detected, an SPCA similarity factor method is built for fault recognition, which fuses both the linear and nonlinear features. Unlike PCA and KPCA, the proposed method takes into account both linear and nonlinear PCs simultaneously, and therefore, it can better exploit the underlying process's structure to enhance fault diagnosis performance. Two case studies involving a simulated nonlinear process and the benchmark Tennessee Eastman process demonstrate that the proposed SPCA approach is more effective than the existing state-of-the-art approach based on KPCA alone, in terms of nonlinear process fault detection and identification.

  15. Relations Between Serial Correlation and Volatility: Is There a LeBaron Effect in Brazil?

    Directory of Open Access Journals (Sweden)

    Regis Augusto Ely

    2014-06-01

    Full Text Available This paper examines the relation between serial correlation and volatility of the Ibovespa index returns and extends the empirical evidence of the LeBaron effect for higher orders of serial correlation. We employ an exponential general autoregressive conditional heteroskedastic model to estimate volatility and an automatic variance ratio statistic to calculate serial correlation. The results support some stylized facts from behavioral finance and help us to explain evidences from empirical studies. We show that (i serial correlation in weekly returns are negative related with volatility, (ii this negative relation is found in daily returns only if we use first order serial correlation, and (iii the effect for weekly returns was not intensified by the 2008 crisis, but a positive relation between volatility and serial correlation for daily returns was identified during that time.

  16. Effect of Different Attentional Instructions on the Acquisition of a Serial Movement Task

    OpenAIRE

    Mei Teng Woo; Jia Yi Chow, Michael Koh

    2014-01-01

    Recent research in attentional focus of instruction has predominantly over-emphasized the investigation of discrete and continuous skills rather than serial skills. The purpose of this study was therefore to examine the effect of different attentional focus instructions on learning a serial skill task (i.e., taekwondo routine) in novice learners. It was predicted that the use of movement outcome instructions could enhance the learning of a serial skill as previously supported in studies exami...

  17. A low-power, radiation-hard gigabit serializer for use in the CMS electromagnetic calorimeter

    CERN Document Server

    Denes, P; Bussat, J M; Wixted, R

    2000-01-01

    An integrated fiber-optic bit serializer and VCSEL driver has been constructed in radiation-hard complementary heterostructure GaAs FET (CHFET) technology. The serializer, which converts 20 parallel inputs into a high-speed serial output, consumes 60 mW at nominal supply voltage when operating at the Large Hadron Collider word rate of 40 MHz (0.8-GB/s serial rate). The integrated driver directly drives a VCSEL and provides 10-mA switched current and 5 mA of prebias. The complete digital optical link thus consumes 90 mW. (6 refs).

  18. Una propuesta de la integración psicocorporal a través de la técnica Alexander y la danza movimiento terapia

    OpenAIRE

    Martínez Martínez, Laura

    2012-01-01

    Este trabajo es una propuesta de integración de la Técnica Alexander y la Danza Movimiento Terapia. Partiendo de la realidad de que ambas técnicas tienen como objetivo final la integración de la dimensión de la psique, del cuerpo y de la emoción, para restaurar el equilibrio integral del ser humano que como consecuencia aporta un estado de salud al individuo. Cada una de ellas se posiciona sobre un camino diferente hacia la curación, aunque comparten muchas bases en común. Una de ellas trata ...

  19. Entre a batuta e o tubo de ensaio: a carreira admirável de Alexandre Borodin Between baton and test tube: the admirable career of Alexander Borodin

    Directory of Open Access Journals (Sweden)

    Carlos A. L. Filgueiras

    2002-11-01

    Full Text Available Alexander Borodin (1833-1887 is a singularity in the history of science. Whereas other scientists may have kept lifelong interests in some artistic field, he was unique in pursuing with great success two parallel careers in both chemistry and music, managing to excell in both to the end of his life. Although he considered himself primarily a chemist, present-day appreciation of his powerful music has greatly surpassed interest for his chemistry. This article treats the life and the unusual double career of the Russian chemist-musician.

  20. A guinada quântica no pensamento de Alexander Wendt e suas implicações para a teoria das Relações Internacionais

    OpenAIRE

    Riche, Flávio Elias

    2012-01-01

    A pesquisa em questão tem por objetivo operar uma análise crítica do pensamento de Alexander Wendt. Tomando por base o termo guinada quântica, é realizada uma clivagem entre a produção teórica que tem em Social theory of international politics seu marco principal e textos mais recentes nos quais o autor postula uma nova ontologia e epistemologia da política internacional, fundadas em aportes oriundos da física quântica e da filosofia da mente. M...

  1. Die Studiensituation an der Friedrich-Alexander-Universität Erlangen-Nürnberg. Abschlussbericht der Studierendenbefragung "FAU-Panel" 2014

    OpenAIRE

    Schulz, Florian

    2014-01-01

    Das "FAU-Panel" ist die zentrale Studierendenbefragung an der Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU). Es wird seit 2011 jährlich durchgeführt. Inzwischen liegen Daten von vier Erhebungen vor. Das "FAU-Panel" ist wichtig, weil es gut dafür geeignet ist, die Meinung der Studierenden fakultäts- und fächerübergreifend zu erfragen. Im Rahmen der Umfrage werden Informationen erhoben, die einen Blick auf die Studienbedingungen an der FAU insgesamt ermöglichen. Ergänzend zu den E...

  2. Die Studiensituation an der Friedrich-Alexander-Universität Erlangen-Nürnberg. Abschlussbericht der Studierendenbefragung "FAU-Panel" 2013

    OpenAIRE

    Schulz, Florian

    2014-01-01

    Das "FAU-Panel" ist die zentrale Studierendenbefragung an der Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU). Das "FAU-Panel" gibt es seit 2011, im Jahr 2012 wurde die zweite, Anfang 2013 die dritte Erhebung der Umfrage durchgeführt. Die Befragung ist Teil einer "Studienverlaufsanalyse", deren Ziel es ist, die Studiensituation sowie die Studienverläufe von Studierenden an der FAU empirisch abzubilden. Das "FAU-Panel" ist wichtig, weil es die einzige Möglichkeit ist, die Meinung d...

  3. Die Studiensituation an der Friedrich-Alexander-Universität Erlangen-Nürnberg. Abschlussbericht der Studierendenbefragung FAU-Panel 2015

    OpenAIRE

    Schmidt, Christopher

    2015-01-01

    Das FAU-Panel ist die zentrale Studierendenbefragung an der Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU). Es wird seit 2011 jährlich durchgeführt. Inzwischen liegen Daten von fünf Erhebungen vor. Das FAU-Panel ist wichtig, da es gut dafür geeignet ist, die Meinungen der Studierenden fakultäts- und fächerübergreifend zu erfragen. Im Rahmen der Umfrage werden Informationen erhoben, die einen Blick auf die Studienbedingungen an der FAU insgesamt ermöglichen. Ergänzend zu den Evalu...

  4. Alexander von Humboldts Weltbild

    Directory of Open Access Journals (Sweden)

    Eberhard Knobloch

    2009-10-01

    Full Text Available Article in German. Abstracts in German and English. The paper is divided into five sections. It begins by showing the similarity between Humboldt's world view and that of the Pythagoreans. It inquires into Humboldt's notion of nature that comprehends natura naturans and natura naturata as well. Numbers are powers of the univers. They especially occur in the 'only decisive method' that is in the method of mean values. This method makes it possible to recognize the law guiding the changes of variable quantities. The botanical arithmetic and earth magnetism provide examples. Finally the paper explains how Humboldt combined the three possible approaches to the world that is thinking, acting, and regarding by means of the notion of knowledge.

  5. Serialization and persistent objects turning data structures into efficient databases

    CERN Document Server

    Soukup, Jiri

    2014-01-01

    Recently, the pressure for fast processing and efficient storage of large data with complex?relations increased beyond the capability of traditional databases. Typical examples include iPhone applications, computer aided design - both electrical and mechanical, biochemistry applications, and incremental compilers. Serialization, which is sometimes used in such situations is notoriously tedious and error prone.In this book, Jiri Soukup and Petr Macha?ek show in detail how to write programs which store their internal data automatically and transparently to disk. Together with special data structure libraries which treat relations among objects as first-class entities, and with a UML class-diagram generator, the core application code is much simplified. The benchmark chapter shows a typical example where persistent data is faster by the order of magnitude than with a traditional database, in both traversing and accessing the data.The authors explore and exploit advanced features of object-oriented languages in a...

  6. Automatic failure detection of serial products using novelty filter

    Directory of Open Access Journals (Sweden)

    Márcia Helena Veleda Moita

    2013-08-01

    Full Text Available The present paper focus on a computer tool that seeks the failure detection of serial products. This paper begins with a brief description about the quality on manufacturing process and points out the relevance of product inspection for detecting fails aiming the product's quality. For such inspection to be accomplished, was used Digital Image Processing Techniques and Artificial Intelligence. This research were done in a mobile phone industry located in the Manaus Industrial Polo - PIM. The tool's methodology localize the possible defect areas and uses a process in which, from a data base composed by pattern images, the Novelty Filter Technique is able to discern regions of  failure through what it was instructed.

  7. Whole brain imaging with Serial Two-Photon Tomography

    Directory of Open Access Journals (Sweden)

    Stephen P Amato

    2016-03-01

    Full Text Available Imaging entire mouse brains at submicron resolution has historically been a challenging undertaking and largely confined to the province of dedicated atlasing initiatives. The has limited systematic investigations into important areas of neuroscience, such as neural circuits, brain mapping and neurodegeneration. In this paper, we describe in detail Serial Two-Photon (STP tomography, a robust, reliable method for imaging entire brains with histological detail. We provide examples of how the basic methodology can be extended to other imaging modalities, such as optical coherence tomography, in order to provide unique contrast mechanisms. Furthermore we provide a survey of the research that STP tomography has enabled in the field of neuroscience, provide examples of how this technology enables quantitative whole brain studies, and discuss the current limitations of STP tomography-based approaches

  8. Statistical design for a small serial dilution series.

    Science.gov (United States)

    Zelterman, Daniel; Tulupyev, Alexander; Heimer, Robert; Abdala, Nadia

    2010-02-10

    We describe statistical plans for a serial dilution series designed to detect and estimate the number of viral particles in a solution. The design addresses a problem when a very limited number of aliquots are available for proliferation. A gamma prior distribution on the number of viral particles allows us to describe the marginal probability distribution of all experimental outcomes. We examine a design that minimizes the expected reciprocal information and compare this with the maximum entropy design. We argue that the maximum entropy design is more useful from the point of view of the laboratory technician. The problem and design are motivated by our study of the viability of human immunodeficiency virus in syringes and other equipment that might mediate blood-borne viral transmission.

  9. Liquid sample delivery techniques for serial femtosecond crystallography.

    Science.gov (United States)

    Weierstall, Uwe

    2014-07-17

    X-ray free-electron lasers overcome the problem of radiation damage in protein crystallography and allow structure determination from micro- and nanocrystals at room temperature. To ensure that consecutive X-ray pulses do not probe previously exposed crystals, the sample needs to be replaced with the X-ray repetition rate, which ranges from 120 Hz at warm linac-based free-electron lasers to 1 MHz at superconducting linacs. Liquid injectors are therefore an essential part of a serial femtosecond crystallography experiment at an X-ray free-electron laser. Here, we compare different techniques of injecting microcrystals in solution into the pulsed X-ray beam in vacuum. Sample waste due to mismatch of the liquid flow rate to the X-ray repetition rate can be addressed through various techniques.

  10. Serial femtosecond crystallography datasets from G protein-coupled receptors.

    Science.gov (United States)

    White, Thomas A; Barty, Anton; Liu, Wei; Ishchenko, Andrii; Zhang, Haitao; Gati, Cornelius; Zatsepin, Nadia A; Basu, Shibom; Oberthür, Dominik; Metz, Markus; Beyerlein, Kenneth R; Yoon, Chun Hong; Yefanov, Oleksandr M; James, Daniel; Wang, Dingjie; Messerschmidt, Marc; Koglin, Jason E; Boutet, Sébastien; Weierstall, Uwe; Cherezov, Vadim

    2016-08-01

    We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human δ-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data.

  11. Unequal Input Voltages Distribution Between the Serial Connected Halfbridges

    Directory of Open Access Journals (Sweden)

    Radovan Ovcarcik

    2006-01-01

    Full Text Available This paper describes a topology of DC-DC converter consisting in two serial connected half-bridges. Secondary circuit is realized like a conventional full-wave rectifier. The main advantage of this topology is the possibility of dividing the input voltage between the half-bridges. The converter is controlled using the phase-shift modulation, which allows a ZVSoperation mode. The voltage unbalance between the inputs causes an important problem of the presented topology. It is necessary to avoid it by the control algorithm, which is described in the text. The practical results show a zero voltage switching technique and the limits of the chosen topology and of the control.

  12. Bit-Serial Adder Based on Quantum Dots

    Science.gov (United States)

    Fijany, Amir; Toomarian, Nikzad; Modarress, Katayoon; Spotnitz, Mathew

    2003-01-01

    A proposed integrated circuit based on quantum-dot cellular automata (QCA) would function as a bit-serial adder. This circuit would serve as a prototype building block for demonstrating the feasibility of quantum-dots computing and for the further development of increasingly complex and increasingly capable quantum-dots computing circuits. QCA-based bit-serial adders would be especially useful in that they would enable the development of highly parallel and systolic processors for implementing fast Fourier, cosine, Hartley, and wavelet transforms. The proposed circuit would complement the QCA-based circuits described in "Implementing Permutation Matrices by Use of Quantum Dots" (NPO-20801), NASA Tech Briefs, Vol. 25, No. 10 (October 2001), page 42 and "Compact Interconnection Networks Based on Quantum Dots" (NPO-20855), which appears elsewhere in this issue. Those articles described the limitations of very-large-scale-integrated (VLSI) circuitry and the major potential advantage afforded by QCA. To recapitulate: In a VLSI circuit, signal paths that are required not to interact with each other must not cross in the same plane. In contrast, for reasons too complex to describe in the limited space available for this article, suitably designed and operated QCA-based signal paths that are required not to interact with each other can nevertheless be allowed to cross each other in the same plane without adverse effect. In principle, this characteristic could be exploited to design compact, coplanar, simple (relative to VLSI) QCA-based networks to implement complex, advanced interconnection schemes. To enable a meaningful description of the proposed bit-serial adder, it is necessary to further recapitulate the description of a quantum-dot cellular automation from the first-mentioned prior article: A quantum-dot cellular automaton contains four quantum dots positioned at the corners of a square cell. The cell contains two extra mobile electrons that can tunnel (in the

  13. Serial femtosecond X-ray diffraction of enveloped virus microcrystals

    Directory of Open Access Journals (Sweden)

    Robert M. Lawrence

    2015-07-01

    Full Text Available Serial femtosecond crystallography (SFX using X-ray free-electron lasers has produced high-resolution, room temperature, time-resolved protein structures. We report preliminary SFX of Sindbis virus, an enveloped icosahedral RNA virus with ∼700 Å diameter. Microcrystals delivered in viscous agarose medium diffracted to ∼40 Å resolution. Small-angle diffuse X-ray scattering overlaid Bragg peaks and analysis suggests this results from molecular transforms of individual particles. Viral proteins undergo structural changes during entry and infection, which could, in principle, be studied with SFX. This is an important step toward determining room temperature structures from virus microcrystals that may enable time-resolved studies of enveloped viruses.

  14. Linguistic ostracism causes prejudice: Support for a serial mediation effect.

    Science.gov (United States)

    Hitlan, Robert Thomas; A Zárate, Michael; Kelly, Kristine M; Catherine DeSoto, M

    2016-01-01

    This research investigated the effects of linguistic ostracism, defined as any communication setting in which a target individual (or group) is ostracized by another individual (or group) in a language that the target has extremely limited ability to understand. Participants were included or ostracized by their group members during a computer-mediated group discussion. Half of the ostracized participants were linguistically ostracized via their group members conversing with one another in a language the participant did not know well (Spanish Ostracism: SO), or in a language the participant did know well (English Ostracism: EO). SO participants reported feeling less similar than both included and EO participants. SO participants also reported being angrier and expressed more prejudice than included participants (and EO participants using effect size estimates). Results also provided support for the hypothesized serial mediation model. Findings are discussed in terms of implications for intergroup relations.

  15. Split-plot designs for robotic serial dilution assays.

    Science.gov (United States)

    Buzas, Jeffrey S; Wager, Carrie G; Lansky, David M

    2011-12-01

    This article explores effective implementation of split-plot designs in serial dilution bioassay using robots. We show that the shortest path for a robot to fill plate wells for a split-plot design is equivalent to the shortest common supersequence problem in combinatorics. We develop an algorithm for finding the shortest common supersequence, provide an R implementation, and explore the distribution of the number of steps required to implement split-plot designs for bioassay through simulation. We also show how to construct collections of split plots that can be filled in a minimal number of steps, thereby demonstrating that split-plot designs can be implemented with nearly the same effort as strip-plot designs. Finally, we provide guidelines for modeling data that result from these designs.

  16. Serial transfer of a transplantable tumor: implications for Marek's vaccine mechanisms.

    Science.gov (United States)

    Hunt, Henry D; Dunn, John R

    2011-06-01

    The mechanism of Marek's disease (MD) vaccination to prevent the lymphoproliferative disease in chickens is not well understood. It is generally recognized that vaccination prevents disease, including the induction of T-cell tumors, but it does not prevent the pathogenic virus from infecting and replicating in the vaccinated host, nor does it prevent bird to bird spread of the oncogenic virus. The stage at which the vaccinated immune system intervenes in the process from infection to the induction of tumors remains obscure. Using a transplantable tumor induced by the Md5 strain of MD virus (MDV), we show that CVI988 vaccination does not prevent the induction of transplantable tumors in the 15I(5) x 7(1) chicken line. A monoclonal tumor with a V beta 1 T-cell receptor spectratype of 207 base pairs was used to follow the transplantable tumor in serial passages in vivo. This transplantable tumor could be passed in vaccinated birds. The length of time between vaccination and challenge (5 to 12 days) had little or no influence on the ability to transfer the tumor. There was variability in the manifestation of the disease produced by the transplanted tumor. Some chickens presented as normal but were still capable of transmitting the transplanted tumor to newly vaccinated recipients via their blood. This indicates that some chickens can control, but not eliminate, the tumor. The variables inducing health or disease in the challenged chickens remain obscure, but environmental or other factors likely depress the immune system allowing the tumor to overwhelm the immune system.

  17. Alexander von Humboldt im Spiegel der spanischen Presse. Zur Wahrnehmung seiner Person und seiner Ideen während der ersten Hälfte des 19. Jahrhunderts

    Directory of Open Access Journals (Sweden)

    Sandra Rebok

    2002-04-01

    Full Text Available Article in German, Abstracts in English, Spanish and German.This article shows the image of Alexander von Humboldt that was created in the Spanish press, both in his professional career and his personal life, from his departure to America in 1799, until his death in 1859. This kind of analysis needs to look into two topics: firstly, the aspects of his personality, his life, his work and his ideas mentioned or emphasized in publications published in those years and secondly, the facets that are not shown; both aspects will form the image that the authors intended to project.In both cases this essay attempts to interpret the intentions that might have been behind the «focus» used by the different publications. As part of this analysis, special importance has been given to the importance attributed to Humboldt in relation to two important events: the Spanish American colonial movement for independence and the beginning of what is nowadays called «modernity».This phase of Spanish History coincides with a changing and complex political-social context, which explains the need to consider not only the moderate press published in Spain under absolutist censorship, but also to include the liberal press of the opposition leaders exiled in London, in order to be able to see the different perception that these papers offered of Alexander von Humboldt.

  18. Capilaroscopia periungueal seriada (CPU como parâmetro de monitoramento da evolução de pacientes com diagnóstico inicial de fenômeno de Raynaud (FRy isolado ou de doença indiferenciada do tecido conjuntivo (DITC Serial nailfold capillaroscopy (NFC as a tool for prospective evaluation of patients with initial isolated Raynaud's phenomenon (RP or undifferentiated connective tissue disease (UCDT

    Directory of Open Access Journals (Sweden)

    Viviane Shinsato Higashi

    2005-12-01

    Raynaud's phenomenon (RP or undifferentiated connective tissue disease (UCTD. METHODS: We evaluated 19 patients with previous diagnosis of isolated Raynaud's Phenomenon or UCTD who had two or more NFC exams within at least one-year interval. RESULTS: Eleven patients have had initial diagnosis of isolated RP; seven maintained the RP diagnosis, three developed Systemic Sclerosis (SSc, and one evolved to Sjögren´s Syndrome (SSj. Eight patients were diagnosed with UCTD in the first evaluation and all of them kept the initial diagnosis. Nine patients presented changes in NFC pattern. Seven patients presented intensification of SD pattern (group A. In three of these patients, the diagnosis has evolved from isolated FRy to SSc. The remaining four cases (one RP and three UCTD maintained the initial diagnosis. Group B included two cases in which the SD pattern has been attenuated or disappeared. One of these patients has evolved from isolated RP to SSj. Ten patients had the NFC pattern unaltered (Group C and all of them have kept the initial diagnosis (four with UCTD and six with RP. All patients who had evolved to SSc have shown intensification or appearance of SD pattern (sensitivity=100%. On the other hand, among the 16 patients who have not evolved to SSc, 12 had not shown appearance or intensification of SD pattern (specificity=75%. CONCLUSIONS: The appearance or intensification of SD pattern in serial NFC analysis during the study period has shown high sensitivity and moderate specificity in regard to the development of SSc.

  19. A case of pigmentary orthochromatic leukodystrophy with findings of proton MR spectroscopy and serial brain MRIs.

    Science.gov (United States)

    Sohn, Sung-Yeon; Ko, Young-Jin; Hong, Ji Man; Kim, Se-Hyuk; Kim, Ho-Sung; Kim, Jang-Hee; Chi, Je-Geun; Moon, So Young

    2010-08-15

    Despite a few case reports over the last 60 years, little progress has been made in defining the phenotype, genotype and pathophysiological mechanisms involved in pigmentary orthochromatic leukodystrophy (POLD). Furthermore, there is currently no data available regarding MRI in patients in the relatively early stages of POLD. Here, we present a 37 year old male patient with brain biopsy-proven POLD who had brain MRIs three times during the first year of his clinical course and proton MR spectroscopy (MRS) throughout his diagnostic evaluation. This patient with POLD was clinically characterized by seizures, rapidly progressive frontally predominant dementia and gait disturbance. The brain MRIs taken serially over the first year revealed progressive development of frontal-predominant white matter changes in the periventricular areas during the earlier periods, which later spread into the deep white matter. His MRS was helpful in the diagnostic approach because the results enabled demyelinating changes to be distinguished from other disease processes such as ischemia, gliosis or tumors. The MRS findings also reflected the disease dynamics because metabolic derangement was observed, even in the white matter that appeared normal. The findings presented here provide insight into the dynamics of POLD.

  20. Visual and Phonological Similarity Effects in Verbal Immediate Serial Recall: A Test with Kanji Materials

    Science.gov (United States)

    Saito, Satoru; Logie, Robert H.; Morita, Aiko; Law, Anna

    2008-01-01

    In a series of three experiments, native speakers of Japanese performed serial ordered written recall of visually presented Japanese kanji characters that varied systematically in visual and phonological similarity. Overall effects of phonological similarity were observed for retention of serial order under silent reading in Experiments 1 and 3…

  1. Cross-domain interference costs during concurrent verbal and spatial serial memory tasks are asymmetric

    NARCIS (Netherlands)

    Morey, Candice C.; Mall, Jonathan T.

    2012-01-01

    Some evidence suggests that memory for serial order is domain-general. Evidence also points to asymmetries in interference between verbal and visual-spatial tasks. We confirm that concurrently remembering verbal and spatial serial lists provokes substantial interference compared with remembering a s

  2. Serial cranial ultrasonography or early MRI for detecting preterm brain injury?

    NARCIS (Netherlands)

    Plaisier, Annemarie; Raets, Marlou M A; Ecury-Goossen, Ginette M; Govaert, Paul; Feijen-Roon, Monique; Reiss, Irwin K M; Smit, Liesbeth S; Lequin, Maarten H; Dudink, Jeroen

    2015-01-01

    OBJECTIVE: To investigate detection ability and feasibility of serial cranial ultrasonography (CUS) and early MRI in preterm brain injury. DESIGN: Prospective cohort study. SETTING: Level III neonatal intensive care unit. PATIENTS: 307 infants, born below 29 weeks of gestation. METHODS: Serial CUS a

  3. A high speed serializer ASIC for ATLAS Liquid Argon calorimeter upgrade

    CERN Document Server

    Liu, T; The ATLAS collaboration

    2011-01-01

    The current front-end electronics of the ATLAS Liquid Argon calorimeters need to be upgraded to sustain the higher radiation levels and data rates expected at the upgraded LHC machine (HL-LHC), which will have 5 times more luminosity than the LHC in its ultimate configuration. This upgrade calls for an optical link system of 100 Gbps per front-end board (FEB). A high speed, low power, radiation tolerant serializer is the critical component in this system. In this paper, we present the design and test results of a single channel 16:1 serializer and the design of a double-channel 16:1 serializer. Both designs are based on a commercial 0.25 μm silicon-on-sapphire CMOS technology. The single channel serializer consists of a serializing unit, a PLL clock generator and a line driver implemented in current mode logic (CML). The serializing unit multiplexes 16 bit parallel LVDS data into 1-bit width serial CMOS data. The serializing unit is composed of a cascade of 2:1 multiplexing circuits based on static D-flip-fl...

  4. The transition model test for serial dependence in mixed-effects models for binary data

    DEFF Research Database (Denmark)

    Breinegaard, Nina; Rabe-Hesketh, Sophia; Skrondal, Anders

    2016-01-01

    Generalized linear mixed models for longitudinal data assume that responses at different occasions are conditionally independent, given the random effects and covariates. Although this assumption is pivotal for consistent estimation, violation due to serial dependence is hard to assess by model...... the targeted root mean squared error of approximation (TRSMEA) as a measure of the population misfit due to serial dependence....

  5. The Automation of Government Publications: Functional Requirements and Selected Software Systems for Serials Controls.

    Science.gov (United States)

    Stephenson, Mary Sue; Purcell, Gary R.

    1985-01-01

    Describes computer-based software and network systems for application to serials and government publications. General and specific functional requirements (hardware, software, file structure) are discussed, and descriptive information about commercially available serials control systems and a list of distributors are provided. (CLB)

  6. 9 CFR 113.8 - In vitro tests for serial release.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false In vitro tests for serial release. 113.8 Section 113.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT... REQUIREMENTS Applicability § 113.8 In vitro tests for serial release. (a) Master Seed which has...

  7. Testing Cross-Sectional Correlation in Large Panel Data Models with Serial Correlation

    Directory of Open Access Journals (Sweden)

    Badi H. Baltagi

    2016-11-01

    Full Text Available This paper considers the problem of testing cross-sectional correlation in large panel data models with serially-correlated errors. It finds that existing tests for cross-sectional correlation encounter size distortions with serial correlation in the errors. To control the size, this paper proposes a modification of Pesaran’s Cross-sectional Dependence (CD test to account for serial correlation of an unknown form in the error term. We derive the limiting distribution of this test as N , T → ∞ . The test is distribution free and allows for unknown forms of serial correlation in the errors. Monte Carlo simulations show that the test has good size and power for large panels when serial correlation in the errors is present.

  8. Psychological profiling of offender characteristics from crime behaviors in serial rape offences.

    Science.gov (United States)

    Kocsis, Richard N; Cooksey, Ray W; Irwin, Harvey J

    2002-04-01

    Criminal psychological profiling has progressively been incorporated into police procedures despite a dearth of empirical research. Indeed, in the study of serial violent crimes for the purpose of psychological profiling, very few original, quantitative, academically reviewed studies actually exist. This article reports on the analysis of 62 incidents of serial sexual assault. The statistical procedure of multidimensional scaling was employed in the analysis of this data, which in turn produced a five-cluster model of serial rapist behavior. First, a central cluster of behaviors were identified that represent common behaviors to all patterns of serial rape. Second, four distinct outlying patterns were identified as demonstrating distinct offence styles, these being assigned the following descriptive labels brutality, intercourse, chaotic, and ritual. Furthermore, analysis of these patterns also identified distinct offender characteristics that allow for the use of empirically robust offender profiles in future serial rape investigations.

  9. The case of Jeffrey Dahmer: sexual serial homicide from a neuropsychiatric developmental perspective.

    Science.gov (United States)

    Silva, J Arturo; Ferrari, Michelle M; Leong, Gregory B

    2002-11-01

    Sexual serial homicidal behavior has received considerable attention during the last three decades. Substantial progress has been made in the development of methods aimed at identifying and apprehending individuals who exhibit these behaviors. In spite of these advances, the origins of sexual serial killing behavior remain for the most part unknown. In this article we propose a biopsychosocial psychiatric model for understanding the origins of sexual serial homicidal behavior from both neuropsychiatric and developmental perspectives, using the case of convicted serial killer Jeffrey Dahmer as the focal point. We propose that his homicidal behavior was intrinsically associated with autistic spectrum psychopathology, specifically Asperger's disorder. The relationship of Asperger's disorder to other psychopathology and to his homicidal behavior is explored. We discuss potential implications of the proposed model for the future study of the causes of sexual serial homicidal crime.

  10. Changing Series: Narrative Models and the Role of the Viewer in Contemporary Television Seriality

    Directory of Open Access Journals (Sweden)

    Veronica Innocenti

    2015-04-01

    Full Text Available In the past few years television serial narratives have gone through some severe changes in the way they are organized from a narrative point of view, as well as in the way they are perceived by the audiences. Our article originates from the necessity of investigating the products of this new wave of serial production, with the purpose of focusing on narrative formulas and on the relationships that serial products establish with their users. Vast serialized narratives are not just texts anymore, they have become complex universes of meaning that last for long time and that have a strong influence on the audiences. The article aims to investigate serial narratives as usable objects, that are not just seen by the public, but that are part of a complex experience. 

  11. Depression and pain: testing of serial multiple mediators

    Directory of Open Access Journals (Sweden)

    Wongpakaran T

    2016-07-01

    Full Text Available Tinakon Wongpakaran,1 Nahathai Wongpakaran,1 Sitthinant Tanchakvaranont,2 Putipong Bookkamana,3 Manee Pinyopornpanish,1 Kamonporn Wannarit,4 Sirina Satthapisit,5 Daochompu Nakawiro,6 Thanita Hiranyatheb,6 Kulvadee Thongpibul7 1Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Kingdom of Thailand; 2Department of Psychiatry, Queen Savang Vadhana Memorial Hospital, Chonburi, Kingdom of Thailand; 3Department of Statistics, Faculty of Science, Chiang Mai University, Chiang Mai, Kingdom of Thailand; 4Department of Psychiatry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Kingdom of Thailand; 5Department of Psychiatry, Khon Kaen Regional Hospital, Khon Kaen, Kingdom of Thailand; 6Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Kingdom of Thailand; 7Department of Psychology, Faculty of Humanities, Chiang Mai University, Chiang Mai, Kingdom of Thailand Purpose: Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders.Participants and methods: An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36, the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed.Results: Perceived stress, self-sacrificing interpersonal style, and cognitive

  12. Estimating HIV incidence among key affected populations in China from serial cross-sectional surveys in 2010–2014

    Directory of Open Access Journals (Sweden)

    Yan Cui

    2016-03-01

    Full Text Available Introduction: HIV incidence is an important measure for monitoring the development of the epidemic, but it is difficult to ascertain. We combined serial HIV prevalence and mortality data to estimate HIV incidence among key affected populations (KAPs in China. Methods: Serial cross-sectional surveys were conducted among KAPs from 2010 to 2014. Trends in HIV prevalence were assessed by the Cochran-Armitage test, adjusted by risk group. HIV incidence was estimated from a mathematical model that describes the relationship between changes in HIV incidence with HIV prevalence and mortality. Results: The crude HIV prevalence for the survey samples remained stable at 1.1 to 1.2% from 2010 to 2014. Among drug users (DUs, HIV prevalence declined from 4.48 to 3.29% (p<0.0001, and among men who have sex with men (MSM, HIV prevalence increased from 5.73 to 7.75% (p<0.0001. Changes in HIV prevalence among female sex workers (FSWs and male patients of sexually transmitted disease clinics were more modest but remained statistically significant (all p<0.0001. The MSM population had the highest incidence estimates at 0.74% in 2011, 0.59% in 2012, 0.57% in 2013 and 0.53% in 2014. Estimates of the annual incidence for DUs and FSWs were very low and may not be reliable. Conclusions: Serial cross-sectional prevalence data from representative samples may be another approach to construct approximate estimates of national HIV incidence among key populations. We observed that the MSM population had the highest incidence for HIV among high-risk groups in China, and we suggest that interventions targeting MSM are urgently needed to curb the growing HIV epidemic.

  13. Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation

    NARCIS (Netherlands)

    Hemels, Martin E. W.; Van Noord, Trudeke; Crijns, Harry J. G. M.; Van Veldhuisen, Dirk J.; Veeger, Nic J. G. M.; Bosker, Hans A.; Wiesfeld, Ans C. P.; Van den Berg, Maarten P.; Ranchor, Adelita V.; Van Gelder, Isabelle C.

    2006-01-01

    OBJECTIVES The VERDICT (Verapamil Versus Digoxin and Acute Versus Routine Serial Cardioversion Trial) is a prospective, randomized study to investigate whether: 1) acutely repeated serial electrical cardioversions (ECVs) after a relapse of atrial fibrillation (AF); and 2) prevention of intracellular

  14. Bottlenecks in serial production lines: A system-theoretic approach

    Directory of Open Access Journals (Sweden)

    C.-T. Kuo

    1996-01-01

    Full Text Available In this work, a new definition of production systems bottlenecks is formulated and analyzed. Specifically, a machine is defined as the bottleneck if the sensitivity of the system's performance index to this machine's production rate in isolation is the largest. Although appealing from the systems point of view, this definition suffers a deficiency due to the fact that the sensitivities involved cannot be either measured on-line or efficiently calculated off-line. To avoid this, the paper develops a method based on indirect but real-time data. From this point of view, the main result of the work is as follows: The bottleneck machine in a serial production line can be identified by analyzing relationships between the so-called manufacturing blockage and manufacturing starvation of each machine. This leads to a simple rule for bottleneck identification. The rule requires neither the calculation of the production rate sensitivities nor the production rate itself. When the probabilities of manufacturing blockages and starvations are not available from on-line measurements, the paper presents their analytical estimates which, under certain conditions, can be used for bottleneck identification. Finally, a case study at an automotive component plant is described.

  15. Implications of the focal beam profile in serial femtosecond crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Galli, Lorenzo [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Chapman, Henry N. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Center for Free-Electron Laser Science; Metcalf, Peter [Univ. of Auckland (New Zealand)

    2015-05-12

    The photon density profile of an X-ray free-electron laser (XFEL) beam at the focal position is a critical parameter for serial femtosecond crystallography (SFX), but is difficult to measure because of the destructive power of the beam. A novel high intensity radiation induced phasing method (HIRIP) has been proposed as a general experimental approach for protein structure determination, but has proved to be sensitive to variations of the X-ray intensity, with uniform incident fluence desired for best performance. Here we show that experimental SFX data collected at the nano-focus chamber of the Coherent X-ray Imaging end-station at the Linac Coherent Light Source using crystals with a limited size distribution suggests an average profile of the X-ray beam that has a large variation of intensity. We propose a new method to improve the quality of high fluence data for HI-RIP, by identifying and removing diffraction patterns from crystals exposed to the low intensity region of the beam. The method requires crystals of average size comparable to the width of the focal spot.

  16. Porting of a serial molecular dynamics code on MIMD platforms

    Energy Technology Data Exchange (ETDEWEB)

    Celino, M. [ENEA Centro Ricerche Casaccia, S. Maria di Galeria, RM (Italy). HPCN Project

    1999-07-01

    A molecular dynamics (MD) code, utilized for the study of atomistic models of metallic systems has been parallelized for MIMD (multiple instructions multiple data) parallel platforms by means of the parallel virtual machine (PVM) message passing library. Since the parallelization implies modifications of the sequential algorithms, these are described from the point of view of the statistical mechanical theory. Furthermore, techniques and parallelization strategies utilized and the MD parallel code are described in detail. Benchmarks on several MIMD platforms (IBM SP1, SP2, Cray T3D, cluster of workstations) allow performances evaluation of the code versus the different characteristics of the parallel platforms. [Italian] Un codice seriale di dinamica molecolare (MD) utilizzato per lo studio di modelli atomici di materiali metallici e' stato parallelizzato per piattaforme parallele MIMD (multiple instructions multiple data) utilizzando librerie del parallel virtual machine (PVM). Poiche' l'operazione di parallelizzazione ha implicato la modifica degli algoritmi seriali del codice, questi vengono descritti ripercorrendo i concetti fondamentali della meccanica statistica. Inoltre sono presentate le tecniche e le strategie di parallelizzazione utilizzate descrivendo in dettaglio il codice parallelo di MD: Risultati di benchmark su diverse piattaforme MIMD (IBM SP1, SP2, Cray T3D, cluster of workstations) permettono di analizzare le performances del codice in funzione delle differenti caratteristiche delle piattaforme parallele.

  17. A novel inert crystal delivery medium for serial femtosecond crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Conrad, Chelsie E.; Basu, Shibom; James, Daniel; Wang, Dingjie; Schaffer, Alexander; Roy-Chowdhury, Shatabdi; Zatsepin, Nadia A.; Aquila, Andrew; Coe, Jesse; Gati, Cornelius; Hunter, Mark S.; Koglin, Jason E.; Kupitz, Christopher; Nelson, Garrett; Subramanian, Ganesh; White, Thomas A.; Zhao, Yun; Zook, James; Boutet, Sébastien; Cherezov, Vadim; Spence, John C. H.; Fromme, Raimund; Weierstall, Uwe; Fromme, Petra

    2015-06-30

    Serial femtosecond crystallography (SFX) has opened a new era in crystallography by permitting nearly damage-free, room-temperature structure determination of challenging proteins such as membrane proteins. In SFX, femtosecond X-ray free-electron laser pulses produce diffraction snapshots from nanocrystals and microcrystals delivered in a liquid jet, which leads to high protein consumption. A slow-moving stream of agarose has been developed as a new crystal delivery medium for SFX. It has low background scattering, is compatible with both soluble and membrane proteins, and can deliver the protein crystals at a wide range of temperatures down to 4°C. Using this crystal-laden agarose stream, the structure of a multi-subunit complex, phycocyanin, was solved to 2.5Å resolution using 300µg of microcrystals embedded into the agarose medium post-crystallization. The agarose delivery method reduces protein consumption by at least 100-fold and has the potential to be used for a diverse population of proteins, including membrane protein complexes.

  18. LabVIEW Serial Driver Software for an Electronic Load

    Science.gov (United States)

    Scullin, Vincent; Garcia, Christopher

    2003-01-01

    A LabVIEW-language computer program enables monitoring and control of a Transistor Devices, Inc., Dynaload WCL232 (or equivalent) electronic load via an RS-232 serial communication link between the electronic load and a remote personal computer. (The electronic load can operate at constant voltage, current, power consumption, or resistance.) The program generates a graphical user interface (GUI) at the computer that looks and acts like the front panel of the electronic load. Once the electronic load has been placed in remote-control mode, this program first queries the electronic load for the present values of all its operational and limit settings, and then drops into a cycle in which it reports the instantaneous voltage, current, and power values in displays that resemble those on the electronic load while monitoring the GUI images of pushbuttons for control actions by the user. By means of the pushbutton images and associated prompts, the user can perform such operations as changing limit values, the operating mode, or the set point. The benefit of this software is that it relieves the user of the need to learn one method for operating the electronic load locally and another method for operating it remotely via a personal computer.

  19. Serial evaluation of hepatic function profile after Fontan operation.

    Science.gov (United States)

    Kaulitz, R; Haber, P; Sturm, E; Schäfer, J; Hofbeck, M

    2014-02-01

    Moderate persistent elevation of the γ-glutamyltransferase (γGT) level is a frequent finding during long-term follow-up of patients with total cavopulmonary connection (TCPC) for palliation of functionally univentricular hearts. Serial intraindividual data revealed a significant increase in the γGT level within a minimum 4-year interval in more than 80 % of cases. The level of γGT elevation showed a significant correlation to hemodynamic parameters such as systemic ventricular end diastolic pressure and mean pulmonary artery pressure, but did not strongly correlate with duration of follow-up or other liver function parameters, which were less frequent and less impressively deranged. None of the patients had signs of synthetic dysfunction. With increasing postoperative follow-up, abnormalities of sonographic hepatic texture including increased echogenicity, inhomogeneity, or liver surface nodularity were found. All 17 patients with liver surface nodularity had a follow-up period of over 10 years. Structural abnormalities did not correlate with biochemical or hemodynamic parameters. Doppler evaluation revealed inspiratory dependence of hepatic vein flow in more than 90 % as a relevant finding after TCPC; a decrease in portal vein flow velocity was observed in many patients. Since long-term survivors after Fontan procedure are at an increased risk of cardiac hepatopathy and cirrhosis, detailed routine investigation and monitoring of hepatic morphology are needed.

  20. SDD: An R Package for Serial Dependence Diagrams

    Directory of Open Access Journals (Sweden)

    Luca Bagnato

    2015-03-01

    Full Text Available Detecting and measuring lag-dependencies is very important in time-series analysis. This study is commonly carried out by focusing on the linear lag-dependencies via the well-known autocorrelogram. However, in practice, there are many situations in which the autocorrelogram fails because of the nonlinear structure of the serial dependence. To cope with this problem, in this paper the R package SDD is introduced. Among the available approaches to analyze the lag-dependencies in an omnibus way, the SDD package considers the autodependogram and some of its variants. The autodependogram, defined by computing the classical Pearson χ2 -statistic at various lags, is a graphical device recently proposed in the literature to analyze lag-dependencies. The concept of reproducibility probability, and several density-based measures of divergence, are considered to define the variants of the autodependogram. An application to daily returns of the Swiss Market Index is also presented to exemplify the use of the package.

  1. Serial pharmacological prescribing practices for tic management in Tourette syndrome.

    Science.gov (United States)

    Farag, Mena; Stern, Jeremy S; Simmons, Helen; Robertson, Mary M

    2015-11-01

    Pharmacological treatments for Tourette syndrome (TS) vary in efficacy between different patients. The evidence base is limited as even high quality controlled studies tend to be of relatively short duration which may lose relevance in clinical usage. Patients are frequently treated with serial agents in the search for efficacy and tolerability. The success of this strategy has not been previously documented. We examined 400 consecutive TS patients seen over a 10-year period, some with a longer prior history in other clinics; 255/400 (64%) were prescribed medication. We present this heterogeneous cohort in terms of the number of drugs they had tried, and as a proxy measure of some benefit of the last drug used, whether it had been prescribed under our supervision for ≥ 5 months. The most commonly prescribed medications were aripiprazole (64%), clonidine (40%), risperidone (30%) and sulpiride (29%) with changes in prescribing practises over the period examined. The number of different drugs tried were one (n = 155), two (n = 69), three (n = 36), four (n = 14), five (n = 15), six (n = 5), seven (n = 2) and eight (n = 1). The data illustrate the difficulty in drug treatment of tics and suggest that even after trials of several agents there is potential benefit in trying further options.

  2. A synchronous serial bus for multidimensional array acoustic logging tool

    Science.gov (United States)

    Men, Baiyong; Ju, Xiaodong; Lu, Junqiang; Qiao, Wenxiao

    2016-12-01

    In high-temperature and spatial borehole applications, a distributed structure is employed in a multidimensional array acoustic logging tool (MDALT) based on a phased array technique for electronic systems. However, new challenges, such as synchronous multichannel data acquisition, multinode real-time control and bulk data transmission in a limited interval, have emerged. To address these challenges, we developed a synchronous serial bus (SSB) in this study. SSB works in a half-duplex mode via a master-slave architecture. It also consists of a single master, several slaves, a differential clock line and a differential data line. The clock line is simplex, whereas the data line is half-duplex and synchronous to the clock line. A reliable communication between the master and the slaves with real-time adjustment of synchronisation is achieved by rationally designing the frame format and protocol of communication and by introducing a scramble code and a Hamming error-correcting code. The control logic of the master and the slaves is realized in field programmable gate array (FPGA) or complex programmable logic device (CPLD). The clock speed of SSB is 10 MHz, the effective data rate of the bulk data transmission is over 99%, and the synchronous errors amongst the slaves are less than 10 ns. Room-temperature test, high-temperature test (175 °C) and field test demonstrate that the proposed SSB is qualified for MDALT.

  3. A novel inert crystal delivery medium for serial femtosecond crystallography

    Directory of Open Access Journals (Sweden)

    Chelsie E. Conrad

    2015-07-01

    Full Text Available Serial femtosecond crystallography (SFX has opened a new era in crystallography by permitting nearly damage-free, room-temperature structure determination of challenging proteins such as membrane proteins. In SFX, femtosecond X-ray free-electron laser pulses produce diffraction snapshots from nanocrystals and microcrystals delivered in a liquid jet, which leads to high protein consumption. A slow-moving stream of agarose has been developed as a new crystal delivery medium for SFX. It has low background scattering, is compatible with both soluble and membrane proteins, and can deliver the protein crystals at a wide range of temperatures down to 4°C. Using this crystal-laden agarose stream, the structure of a multi-subunit complex, phycocyanin, was solved to 2.5 Å resolution using 300 µg of microcrystals embedded into the agarose medium post-crystallization. The agarose delivery method reduces protein consumption by at least 100-fold and has the potential to be used for a diverse population of proteins, including membrane protein complexes.

  4. Neutral null models for diversity in serial transfer evolution experiments.

    Science.gov (United States)

    Harpak, Arbel; Sella, Guy

    2014-09-01

    Evolution experiments with microorganisms coupled with genome-wide sequencing now allow for the systematic study of population genetic processes under a wide range of conditions. In learning about these processes in natural, sexual populations, neutral models that describe the behavior of diversity and divergence summaries have played a pivotal role. It is therefore natural to ask whether neutral models, suitably modified, could be useful in the context of evolution experiments. Here, we introduce coalescent models for polymorphism and divergence under the most common experimental evolution assay, a serial transfer experiment. This relatively simple setting allows us to address several issues that could affect diversity patterns in evolution experiments, whether selection is operating or not: the transient behavior of neutral polymorphism in an experiment beginning from a single clone, the effects of randomness in the timing of cell division and noisiness in population size in the dilution stage. In our analyses and discussion, we emphasize the implications for experiments aimed at measuring diversity patterns and making inferences about population genetic processes based on these measurements.

  5. Serial monogamy and sex ratio bias in Nazca boobies.

    Science.gov (United States)

    Maness, Terri J; Anderson, David J

    2007-08-22

    Biased operational sex ratios (OSRs) can drive sexual selection on members of the over-represented sex via competition for mates, causing higher variance and skew in reproductive success (RS) among them if an individual's quality is a persistent characteristic. Alternatively, costs of reproduction may degrade breeding performance, creating the opportunity for members of the limiting sex to switch mates adaptively, effectively homogenizing variance and skew in RS among the sex in excess. We tested these two contrasting models in a male-biased population of the Nazca booby (Sula granti) with demonstrated costs of reproduction with data on total RS over a 14-year period. Variances and skews in RS were similar, and males changed from breeder to non-breeder more frequently than females. Under the persistent individual quality model, females should mate only with high quality males, and non-breeding males should seldom enter the breeding pool, yet 45% of non-breeding males (re)entered the breeding pool each year on average. Many Nazca booby females apparently exchange a depleted male for a new mate from the pool of current non-breeder males. Our evidence linking serial monogamy to costs of reproduction is novel and suggests selection on female mating preferences based on an interaction between at least two life-history components (OSR and reproductive effort).

  6. Prophetic Visions, Quality Serials: Twin Peaks’ new mode of storytelling

    Directory of Open Access Journals (Sweden)

    Mikhail L. Skoptsov

    2015-05-01

    Full Text Available Following the April 1990 debut of Twin Peaks on ABC, the vision - a sequence of images that relates information of the narrative future or past – has become a staple of numerous network, basic cable and premium cable serials, including Buffy the Vampire Slayer (WB, Battlestar Galactica (SyFy and Game of Thrones (HBO. This paper argues that Peaks in effect had introduced a mode of storytelling called “visio-narrative,” which draws on ancient epic poetry by focusing on main characters that receive knowledge from enigmatic, god-like figures that control his world. Their visions disrupt linear storytelling, allowing a series to embrace the formal aspects of the medium and create the impression that its disparate episodes constitute a singular whole. This helps them qualify as ‘quality TV’, while disguising instances of authorial manipulation evident within the texts as products of divine internal causality.As a result, all narrative events, no matter how coincidental or inconsequential, become part of a grand design. Close examination of Twin Peaks and Carnivàle will demonstrate how the mode operates, why it is popular among modern storytellers and how it can elevate a show’s cultural status.

  7. Design of Rapid Serial Visual Presentation Panel for Arabic Readers

    Directory of Open Access Journals (Sweden)

    Mohamed Zaki Ramadan

    2016-11-01

    Full Text Available The primary objective of the Rapid Serial Visual Presentation Panel (RSVPP was to aid in understanding the Arabic moving messages in different public places such as mosques, hospitals, factories, emergencies, malls, and markets. RSVPP is potentially useful tool for presenting important intensive information in a rapid manner. Speed of showing words in the screens, colors of fonts/backgrounds, font styles, and polarization are some important factors that may affect the reading comprehended and speed. The initial stage of the project was to study the available panels that were designed in English formats. The layout of the new configuration of the designed panel as well as the requirements for developing was made in order to make realistic recommendations considering environmental and human users as a next stage. Message speed (180, 240, and 300 words per minute (wpm, space between words (one, two characters, and fore/background colors (red, blue, green and white on black background were independent variables. Percent of correct response, percent of correct comprehension and preference rating were dependent responses. Results of this study recommended that moving 240 wpm with one character among words in green character/black background color was superior over the other conditions.

  8. Serial cranial computed tomography in acute infantile hemiplegia

    Energy Technology Data Exchange (ETDEWEB)

    Kataoka, Kenkichi; Nakagawa, Yoshihiro; Hojo, Hiroatsu; Yamasaki, Shun (Shizuoka Prefectural Children' s Hospital (Japan)); Mochizuki, Yasuhiro; Nakano, Shozo

    1982-11-01

    Serial cranial computed tomography (CCT) was studied in 20 children with acute infantile hemiplegia. These children were devided into two groups: hemiplegia following fever, hemiconvulsion and unconsiousness (the convulsive group) and hemiplegia without convulsion (the non-convulsive group). There were 15 cases in the convulsive group and 5 cases in the non-convulsive group. We could investigate the CCT immediately after the onset in 6 convulsive cases and 3 non-convulsive cases, but the immediate CCT revealed no abnormalities in both groups. Within several days after the onset the abnormally low density area appeared on the CCT in both groups. In three cases there were abnormally high density areas complicating these abnormalities. Over more than a month, the hemispheric low density area changed into the hemispheric atrophy and the lobar low density area changed into the focal wedge-shaped atrophy or diminished. The small or lacunar low density area changed into the low density spot and the hemorrhagic infarction into the porencephaly. The occlusion of the internal carotid artery were found in two non-convulsive cases and the stenosis of the internal carotid artery in a convulsive case with purulent meningitis.

  9. Alexander von Humboldt und Carlos Montúfar als Reisegefährten: ein Vergleich ihrer Tagebücher zum Chimborazo-Aufstieg

    Directory of Open Access Journals (Sweden)

    Reinhard Andress

    2011-03-01

    Full Text Available ZusammenfassungAls Alexander von Humboldt im Juni 1802 von Quito aus zum Rest seiner lateinamerikanischen Forschungsreise aufbrach, begleitete ihn, abgesehen von Aimé Bonpland, Carlos Montúfar bis nach Europa zurück begleitet, u.a. auch auf beim Versuch, den Chimborazo zu ersteigen. Bis kurz vor der Stadt Cajamarca im heutigen Peru schrieb Montúfar ein relativ unbekanntes Tagebuch zur Reise. Nach einem kurzen Ausflug in das Leben von Humboldts Begleiter steht im Zentrum der weiteren Ausführungen die Frage, ob sein Tagebuch ein anderes Licht auf Humboldt und speziell auf den Aufstiegsversuch wirft. Das läuft auf einen Vergleich der Tagebücher der beiden Reisegefährten hinaus und auf den Versuch, die scheinbaren Widersprüche aufzulösen.AbstractWhen Alexander von Humboldt left Quito in June 1802 in order to undertake the rest of his Latin-American trip of exploration, he was accompanied, aside from Aimé Bonpland, by Carlos Montúfar all the way back to Europe, including the attempt to scale the Chimborazo. Up to shortly before the city of Cajamarca in today’s Peru, Montúfar wrote an relatively unknown diary account of their travels. After a brief excursion into the life of Humboldt’s companion, the question is considered whether his diary sheds a different light on Humboldt and specifically on the mountain climb. That amounts to a comparison of the diaries of the two travel companions and to an attempt to explain the apparent contradictions.ResumenCuando Alexander von Humboldt salió de Quito en junio de 1802 para continuar con el resto de su viaje de exploración por la América Latina, fue acompañado por Carlos Montúfar además de Aimé Bonpland hasta que volvieron a Europa. Este trayecto incluía la tentativa de llegar a la cima del Chimborazo. Hasta un poco antes de la cuidad de Cajamarca que está en el Perú de hoy día, Montúfar mantenía un diario relativamente no conocido del viaje. Después de una breve excursión por

  10. Design of high speed serializer for interchip data communications with phase frequency detector

    Directory of Open Access Journals (Sweden)

    Vinod Kumar Nirala

    2016-05-01

    Full Text Available The part of project work presented in this report deals with high speed inter-chip serial data transfer. Serializer used for parallel to serial conversion is of not only high speed but also power efficient. The utilization of CMOS based serializer as well as CML (current mode logic based serializer at proper places helps in reducing the power requirement without compromising the adequate speed. Tree structure is adopted for the realization of higher order serializer(8:1. The basic building block is 2:1 serializer. The high frequency clock is generated with the help of delay locked loop (DLL based clock multiplier unit (CMU. Pre-charge type phase frequency detector (PFD is used to obtain better phase resolution which is necessary for enhancing the jitter performance of the transmitter. DLL generates 8 phases which are combined by a logic block to produce a clock of frequency 4 times input frequency of DLL. To obtain different other frequencies divider is utilized.

  11. Natural born killers?: the development of the sexually sadistic serial killer.

    Science.gov (United States)

    Johnson, B R; Becker, J V

    1997-01-01

    Today's society seems enthralled with serial killers in the news and the media. Forensic psychiatrists often interview serial killers after they have been caught. There are retrospective studies and case reports of individuals who have committed sexually sadistic serial murders. However, there exists a dearth of case reports on adolescents who have expressed serious fantasies about becoming serial killer prior to actualizing their fantasy. This article presents nine clinical cases of 14- to 18-year-olds who have clinically significant fantasies of becoming a serial killer. Similarities exist in these adolescent cases when compared with retrospective studies and case reports of serial killers on the role of sexually sadistic fantasies and actual killings. Since it has been established that sexual paraphilias may develop at a young age, one can surmise that sadistic paraphilias may also develop in some adolescents. The question is posed, can we predict which of these adolescents may go on to actually become serial killers? This article focuses on how the sexually sadistic fantasy can eventually be acted out and possible motives for the act to be repeated multiple times. Finally, recommendations are made about assessing and treating a youngster who expresses violent sexually sadistic killing fantasies so that attempts can be made to interrupt the progression to actual killing.

  12. Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds., The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015

    Directory of Open Access Journals (Sweden)

    William C. Miller

    2017-03-01

    Full Text Available A review of the book: Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds., The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015

  13. Alexander Agadjanian and Kathy Rousselet (Eds.) (2011). Parish and Community in Today’s Orthodox Christianity: The Grassroots of Russian Religiosity. (Prikhod i obshchina v sovremennom pravoslavii: kornevaia sistema rossiiskoi religioznosti). Moscow: Ves’ Mir (in Russian). – 368 pages

    OpenAIRE

    Ludmila Zhukova

    2014-01-01

    Book review: Alexander Agadjanian and Kathy Rousselet (Eds.) (2011). Parish and Community in Today’s Orthodox Christianity: The Grassroots of Russian Religiosity. (Prikhod i obshchina v sovremennom pravoslavii: kornevaia sistema rossiiskoi religioznosti). Moscow: Ves’ Mir (in Russian). – 368 pages

  14. Destructive hostility: the Jeffrey Dahmer case. A psychiatric and forensic study of a serial killer.

    Science.gov (United States)

    Jentzen, J; Palermo, G; Johnson, L T; Ho, K C; Stormo, K A; Teggatz, J

    1994-12-01

    We were involved as forensic experts in the case of the serial killer Jeffrey Dahmer. We discuss the scene and victim autopsy findings, with a brief consideration of the basic emotion of hostility. These findings support the thesis that at the basis of this serial killer's behavior were primary unconscious feelings of hate that he had channeled into a sadistic programmed destruction of 17 young men. The interview of the serial killer, the photographic scene documentation, and the autopsy findings stress the ambivalent homosexuality of the killer, his sexual sadism, his obsessive fetishism, and his possible cannibalism and necrophilia.

  15. Development of gallium arsenide high-speed, low-power serial parallel interface modules: Executive summary

    Science.gov (United States)

    1988-01-01

    Final report to NASA LeRC on the development of gallium arsenide (GaAS) high-speed, low power serial/parallel interface modules. The report discusses the development and test of a family of 16, 32 and 64 bit parallel to serial and serial to parallel integrated circuits using a self aligned gate MESFET technology developed at the Honeywell Sensors and Signal Processing Laboratory. Lab testing demonstrated 1.3 GHz clock rates at a power of 300 mW. This work was accomplished under contract number NAS3-24676.

  16. Using the OCLC union listing component for a statewide health sciences union list of serials.

    Science.gov (United States)

    Sutton, L S; Wolfgram, P A

    1986-04-01

    Union lists of serials are critical to the effective operation of interlibrary loan networks. The Michigan Health Sciences Libraries Association used the OCLC union list component to produce the Michigan Statewide Health Sciences Union List of Serials (MISHULS). MISHULS, which includes the serials holdings of ninety-three hospital health sciences libraries, is a subset of a statewide multi-type union list maintained on OCLC. The rationale for a statewide list and the criteria for choosing vendors are discussed. Typical costs are provided. Funding sources are identified and a unique approach to decentralized input is described. The benefits of resource sharing in a larger, multi-type library network are also explored.

  17. E-serials cataloging access to continuing and integrating resources via the catalog and the web

    CERN Document Server

    Cole, Jim

    2014-01-01

    This comprehensive guide examines the state of electronic serials cataloging with special attention paid to online capacities. E-Serials Cataloging: Access to Continuing and Integrating Resources via the Catalog and the Web presents a review of the e-serials cataloging methods of the 1990s and discusses the international standards (ISSN, ISBD[ER], AACR2) that are applicable. It puts the concept of online accessibility into historical perspective and offers a look at current applications to consider. Practicing librarians, catalogers and administrators of technical services, cataloging and serv

  18. A 16:1 Serializer ASIC for Data Transmission at 5 Gbps

    CERN Document Server

    Gong, D; The ATLAS collaboration

    2010-01-01

    A high speed, low power 16:1 serializer has been developed with a commercial 0.25 μm silicon-on-sapphire CMOS technology. The serializer operates from 4.0 to 5.7 Gbps. Total jitter is 62 ps and the eye openning of the bathtub curve is 122 ps at bit rate error of 10-12 at 5 Gbps. Power consumption is 463 mW at 5 Gbps. A proton beam test indicates the serializer is suitable for applications in high energy physics experiments.

  19. Serial measurements of cardiac biomarkers in patients after allogeneic hematopoietic stem cell transplantation

    Directory of Open Access Journals (Sweden)

    Roziakova Lubica

    2012-02-01

    Full Text Available Abstract Background Previous therapy with anthracyclines (ANT and conditioning regimen followed by hematopoietic stem cell transplantation (HSCT represents a high risk for development of cardiotoxicity. The aim of this study was to assess subclinical myocardial damage after HSCT using echocardiography and cardiac biomarkers - high sensitive cardiac troponin T (hs-cTnT and N-terminal pro-B-type natriuretic peptide (NT-proBNP and to identify patients at risk of developing clinical cardiotoxicity. Patients and methods Thirty-seven patients who were treated with allogeneic HSCT for hematologic diseases at median age of 28 years at time of HSCT were studied. Conditioning regimen included either chemotherapy without total body irradiation (TBI or combination of chemotherapy with TBI. Twenty-nine (78,3% patients were pretreated with ANT therapy. Cardiac biomarkers were serially measured before conditioning regimen and at days 1, 14 and 30 after HSCT. Cardiac systolic and diastolic functions were assessed before conditioning regimen and 1 month after HSCT by echocardiography. Results The changes in plasma NT-proBNP and hs-cTnT levels during the 30 days following the HSCT were statistically significant (P P Conclusions Elevations in both cardiac biomarkers were found before clinical signs of cardiotoxicity developed. Persistent elevations in NT-pro-BNP and hs-cTnT concentrations simultaneously for a period exceeding 14 days might be used for identification of patients at risk of developing cardiotoxicity and requiring further cardiological follow up.

  20. Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient

    Science.gov (United States)

    Dazert, Eva; Colombi, Marco; Boldanova, Tujana; Moes, Suzette; Adametz, David; Quagliata, Luca; Roth, Volker; Terracciano, Luigi; Heim, Markus H.; Jenoe, Paul; Hall, Michael N.

    2016-01-01

    Compensatory signaling pathways in tumors confer resistance to targeted therapy, but the pathways and their mechanisms of activation remain largely unknown. We describe a procedure for quantitative proteomics and phosphoproteomics on snap-frozen biopsies of hepatocellular carcinoma (HCC) and matched nontumor liver tissue. We applied this procedure to monitor signaling pathways in serial biopsies taken from an HCC patient before and during treatment with the multikinase inhibitor sorafenib. At diagnosis, the patient had an advanced HCC. At the time of the second biopsy, abdominal imaging revealed progressive disease despite sorafenib treatment. Sorafenib was confirmed to inhibit MAPK signaling in the tumor, as measured by reduced ribosomal protein S6 kinase phosphorylation. Hierarchical clustering and enrichment analysis revealed pathways broadly implicated in tumor progression and resistance, such as epithelial-to-mesenchymal transition and cell adhesion pathways. Thus, we describe a protocol for quantitative analysis of oncogenic pathways in HCC biopsies and obtained first insights into the effect of sorafenib in vivo. This protocol will allow elucidation of mechanisms of resistance and enable precision medicine. PMID:26787912

  1. Serial analysis of gene expression (SAGE in bovine trypanotolerance: preliminary results

    Directory of Open Access Journals (Sweden)

    David Berthier

    2003-06-01

    Full Text Available Abstract In Africa, trypanosomosis is a tsetse-transmitted disease which represents the most important constraint to livestock production. Several indigenous West African taurine (Bos taurus breeds, such as the Longhorn (N'Dama cattle are well known to control trypanosome infections. This genetic ability named "trypanotolerance" results from various biological mechanisms under multigenic control. The methodologies used so far have not succeeded in identifying the complete pool of genes involved in trypanotolerance. New post genomic biotechnologies such as transcriptome analyses are efficient in characterising the pool of genes involved in the expression of specific biological functions. We used the serial analysis of gene expression (SAGE technique to construct, from Peripheral Blood Mononuclear Cells of an N'Dama cow, 2 total mRNA transcript libraries, at day 0 of a Trypanosoma congolense experimental infection and at day 10 post-infection, corresponding to the peak of parasitaemia. Bioinformatic comparisons in the bovine genomic databases allowed the identification of 187 up- and down- regulated genes, EST and unknown functional genes. Identification of the genes involved in trypanotolerance will allow to set up specific microarray sets for further metabolic and pharmacological studies and to design field marker-assisted selection by introgression programmes.

  2. Serial MRI and MRS studies with unusual findings in Rasmussen's encephalitis

    Energy Technology Data Exchange (ETDEWEB)

    Tuerkdogan-Soezueer, D. [Department of Pediatric Neurology, Institute of Neurological Sciences, Marmara University, Istanbul (Turkey); Oezek, M.M.; Pamir, M.N. [Department of Neurosurgery, Institute of Neurological Sciences, Marmara University, Istanbul (Turkey); Sav, A. [Department of Pathology, Institute of Neurological Sciences, Marmara University, Istanbul (Turkey); Dincer, A. [Radyomar MR Center, Istanbul (Turkey)

    2000-06-01

    Rasmussen's syndrome is characterized by intractable seizures and progressive neuropsychiatric deterioration secondary to unilateral cortical inflammation and tissue destruction. Diagnosis of Rasmussen's syndrome in the early phase depends mainly on the clinical features. Neuroimaging and histopathologic examinations may not be specific during this period. We report a case of Rasmussen's syndrome followed by serial MRI and magnetic resonance spectroscopy (MRS) studies over a 3- to 16-month period. A healthy 6-year-old boy presented with focal motor seizures. An MRI study demonstrated prominent enlargement and T2 hyperintensity of the left mesial temporal lobe and perisylvian region. This early finding evolved to volume loss and later progressive atrophy of the ipsilateral hemisphere when epilepsia partialis continua occurred. Being aware of those early MRI features in a patient with increasing frequency of focal motor seizures should suggest Rasmussen's syndrome. In addition, we found prominently increased myoinositol concentration in atrophic cortex which might reflect increased gliosis in the late period of the disease. (orig.)

  3. Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset

    Directory of Open Access Journals (Sweden)

    Oleg Blyuss

    2015-01-01

    Full Text Available Early detection of ovarian cancer through screening may have impact on mortality from the disease. Approaches based on CA125 cut-off have not been effective. Longitudinal algorithms such as the Risk of Ovarian Cancer Algorithm (ROCA to interpret CA125 have been shown to have higher sensitivity and specificity than a single cut-off. The aim of this study was to investigate whether other ovarian cancer-related biomarkers, Human Epididymis 4 (HE4, glycodelin, mesothelin, matrix metalloproteinase 7 (MMP7, and cytokeratin 19 fragment (CYFRA 21-1, could improve the performance of CA125 in detecting ovarian cancer earlier. Serum samples (single and serial predating diagnosis from 47 women taking part in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS who went on to develop primary invasive ovarian, fallopian tube, or peritoneal cancer (index cancer (170 samples and 179 matched controls (893 samples were included in the study. A multiplex immunobased assay platform (Becton Dickinson allowing simultaneous measurement of the six serum markers was used. The area under the ROC curve for the panel of three biomarkers (CA125, HE4, and glycodelin was higher than for CA125 alone for all analysed time groups, indicating that these markers can improve on sensitivity of CA125 alone for ovarian cancer detection.

  4. Serial measurements of serum human placental lactogen (hPL) and serial ultrasound examinations in the evaluation of fetal growth

    DEFF Research Database (Denmark)

    Sørensen, Steen; von Tabouillot, D; Schioler, V

    2000-01-01

    was associated with a trend towards low and decreasing hPL and with an increasing intrauterine growth velocity and birth weight deviation. In conclusion the rate of change of serial hPL measurements correlated well to intrauterine fetal growth velocity in the third trimester as estimated by ultrasound......PL MoM values was carried out for each pregnancy to find the slope of the line (hPL-slope); at least 3 serum hPL values were required. The estimated fetal weight and weight-for-age at birth was expressed in Z-scores. The individual intrauterine growth velocity was calculated by regression analysis...... deviation, smoking in pregnancy and diagnosis of preeclampsia. A significant correlation was found between the hPL-slope and the intrauterine fetal growth velocity (r=0.34), and between hPL-slope and birth weight deviation (r=0.32). Mean hPL was correlated to birth weight deviation (r=0.27), but only very...

  5. [Researchers training in the context of the collaborative projects: experiences of Instituto de Medicina Tropical "Alexander von Humbolt", Universidad Peruana Cayetano Heredia].

    Science.gov (United States)

    Gotuzzo, Eduardo; González, Elsa; Verdonck, Kristien

    2010-09-01

    Research is a main element for human and social development. Under this point of view, it involves particular challenges and opportunities for the so-called "developing countries". An approach for those challenges and opportunities comes from the analysis of two interrelated activities; the training of new researchers and the research development with institutions or researchers which are external to the institution ("collaborative research"). Both activities are essential for the consolidation, widening and updating of the institutional capabilities for scientific production. We present here the experiences of the Instituto de Medicina Tropical "Alexander von Humboldt" of the Universidad Peruana Cayetano Heredia, in relation to the training of new researchers, we discuss the four elements we consider key for this process; the promotion of stimulating environments for research, the proactive identification of fellows, the complementary advice and networks consolidation; and we analyze three successful models of international collaboration for the training of new researchers under different institutional approaches.

  6. From Outer Space to the Circus Tent. Science Fiction and the Problems of ’68 in Alexander Kluge’s »Die Ungläubige«

    Directory of Open Access Journals (Sweden)

    Kirkland A. Fulk

    2013-11-01

    Full Text Available This paper explores Alexander Kluge’s forgotten work of science fiction Die Ungläubige , Kluge’s literary addendum to Die Artisten in der Zirkuskuppel: ratlos , and places it against the background of the aesthetic debates of 1968 and Kluge’s larger canon. Why did Kluge turn to science fiction at this particular time? How does this genre interrogate, expand on, or even challenge our understanding of Kluge and his aesthetic project, which in many ways cannot be thought apart from this pivotal period in German post-war history? Kluge’s text is at once a sharp critique of capitalist structures and a critical representation of utopian visions of the future, making the work an important piece of aesthetic, social and political commentary.

  7. Le politique, opérateur de la construction des savoirs géographiques modernes: l'exemple des voyages d'Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Laura Péaud

    2011-10-01

    Full Text Available RésuméA la charnière du XVIIIème et du XIXème siècle, Alexander von Humboldt réalise une série de voyages scientifiques et géographiques en Europe, en Amérique et en Asie. Connus en grande partie par sa très riche correspondance, ces voyages sont tous marqués par la présence et l’intervention d’acteurs du monde politique européen. Par leur soutien financier, matériel et moral, ainsi que par leur délimitation spatiale, temporelle voire thématique des objets des expéditions, ceux-ci structurent pratiquement et intellectuellement le déroulement des expéditions humboldtiennes.Aux alentours du moment 1800, la géographie se trouve alors engagée dans un mouvement de construction disciplinaire, questionnant ses objets, ses méthodes et ses pratiques. Inséré dans ce processus, le voyage constitue un enjeu identitaire fort de l’élaboration et de la définition des savoirs géographiques modernes. La participation des acteurs politiques dans les voyages interroge leur rôle d’opérateurs de la fabrique scientifique. A partir de l’exemple humboldtien, dans une optique d’histoire et d’épistémologie de la géographie, cet article propose d’engager une analyse relationnelle du couple géographie/politique.ZusammenfassungZwischen 1799 und 1829 unternahm Alexander von Humboldt eine Reihe wissenschaftlicher Reisen durch Europa, Amerika und Asien. Nicht zuletzt dank der überlieferten Korrespondenz sind die Reisen sehr gut dokumentiert: Politische Akteure spielten eine große Rolle bei der Planung und Umsetzung der Reisen. So unterstützten sie Humboldts Reisen sowohl mit materiellen als auch ideellen Mitteln. Mitunter nahmen sie Einfluss auf Routen sowie auf Dauer und thematische Ausrichtung der Reisen. Dies strukturierte die Humboldt’schen Reisen intellektuell und in ihrer praktischen Umsetzung.Um 1800 bildete sich die Geographie zur wissenschaftlichen Disziplin heraus, ihre Forschungsgegenstände, Methoden und

  8. “Ein beschränkter Verstandesmensch ohne Einbildungskraft” Anmerkungen zu Friedrich Schillers Urteil über Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Ingo Schwarz

    2003-04-01

    Full Text Available Article in German, Abstract in English. In a letter dated August 6, 1797 to his friend Christian Gottfried Körner, Friedrich Schiller characterized Alexander von Humboldt as a person of limited imagination, who, in spite of his numerous activities, would never be able to achieve greatness in his scientific pursuits. Yet, only in 1849 did Humboldt learn of Schiller’s opinion from the published correspondence between Schiller and Körner. Nonetheless, Humboldt declared that this basically unjust characterization of himself by Schiller would never prevent him from admiring the great German playwright and poet; moreover, Humboldt looked for comfort in a similarly harsh opinion of Johann Gottfried Herder also expressed by Schiller. In the end, Humboldt could barely conceal his feelings of disappointment regarding Schiller’s opinion, especially because Humboldt had considered Schiller to be his friend.

  9. Aportes a la Geomorfología, Geología y Vulcanología de Costa Rica por Alexander von Frantzius

    OpenAIRE

    Asdrúbal Vargas

    2014-01-01

    En este trabajo se describen varios aportes realizados por el geocientífico alemán Alexander von Frantzius en varias geociencias. Frantzius fue pionero en la exploración y descripción del entorno geológico y geomorfológico de varias regiones en Costa Rica en la segunda mitad del siglo XIX. Asociado a su labor de médico también exploró el valle del río Reventazón, Pirris y Tempisque en los cuales además de las descripciones de las rocas aflorantes describía aspectos geomorfológicos, hidrológic...

  10. Novel Method to Improve Radiologist Agreement in Interpretation of Serial Chest Radiographs in the ICU

    Directory of Open Access Journals (Sweden)

    Denise A Castro

    2015-01-01

    Full Text Available Objectives: To determine whether a novel method and device, called a variable attenuation plate (VAP, which equalizes chest radiographic appearance and allows for synchronization of manual image windowing with comparison studies, would improve consistency in interpretation. Materials and Methods: Research ethics board approved the prospective cohort pilot study, which included 50 patients in the intensive care unit (ICU undergoing two serial chest radiographs with a VAP placed on each one of them. The VAP allowed for equalization of density and contrast between the patients′ serial chest radiographs. Three radiologists interpreted all the studies with and without the use of VAP. Kappa and percent agreement was used to calculate agreement between radiologists′ interpretations with and without the plate. Results: Radiologist agreement was substantially higher with the VAP method, as compared to that with the non-VAP method. Kappa values between Radiologists A and B, A and C, and B and C were 46%, 55%, and 51%, respectively, which improved to 73%, 81%, and 66%, respectively, with the use of VAP. Discrepant report impressions (i.e., one radiologist′s impression of unchanged versus one or both of the other radiologists stating improved or worsened in their impression ranged from 24 to 28.6% without the use of VAP and from 10 to 16% with the use of VAP (χ2 = 7.454, P < 0.01. Opposing views (i.e., one radiologist′s impression of improved and one of the others stating disease progression or vice versa were reported in 7 (12% cases in the non-VAP group and 4 (7% cases in the VAP group (χ2 = 0.85, P = 0.54. Conclusion: Numerous factors play a role in image acquisition and image quality, which can contribute to poor consistency and reliability of portable chest radiographic interpretations. Radiologists′ agreement of image interpretation can be improved by use of a novel method consisting of a VAP and associated software and has the potential

  11. Non-Euclidean Space, Movement and Astronomy in Modern Art: Alexander Calder’s Mobiles and Ben Nicholson’s Reliefs

    Directory of Open Access Journals (Sweden)

    Malloy Vanja

    2013-09-01

    Full Text Available John Keats once wrote that ‘there is no such thing as time and space’ rather, believing that time and space are mental constructs that are subject to a variety of forms and as diverse as the human mind. In the 1920s through the 1930s, modern physics in many ways supported this idea through the various philosophical writings on the Theory of General Relativity to the masses by scientists such as Arthur Eddington and Albert Einstein. These new concepts of modern physics fundamentally changed our understanding of time and space and had substantial philosophical implications, which were absorbed by modern artists resulting in the 1936 Dimensionist Manifesto. Seeking to internalize the developments of modern science within modern art, this manifesto was widely endorsed by the most prominent figures of the avant-garde such as Marcel Duchamp, Jean Arp, Naum Gabo, Joan Miró, László Moholy-Nagy, Wassily Kandinsky and Alexander Calder. Of particular interest to this manifesto was the new concept of the fourth-dimension, which in many ways revolutionized the arts. Importantly, its interpretation varied widely in the artistic community, ranging from a purely physical four-dimensional space, to a kinetic concept of space in which space and time are linked, to a metaphysical interest in a space that exists beyond the material realm. The impact of modern science and astronomy on avant-garde art is currently a bourgeoning area of research with considerable implications to our rethinking of substantial artistic figures of this era. Through a case study of Alexander Calder’s Mobiles and Ben Nicholson’s Reliefs, this paper explores how these artworks were informed by an interest in modern science.

  12. HDL Design for 1 Zetta Bits Per Second (1 Zbps Multichannel 64:1 LVDS Data Serializer & De-Serializer ASIC Array Card Design for 6th Sense and Future Ultra High Wireless and Mobile Communication Protocol Cards

    Directory of Open Access Journals (Sweden)

    P. N. V. M SASTRY

    2015-01-01

    Full Text Available The Aim is to HDL Design & Implementation for Exa Bit Rate Multichannel 64:1 LVDS Data Serializer & De-Serializer ASIC Array Card for Ultra High Speed Wireless Communication Products like Network On Chip Routers, Data Bus Communication Interface Applications, Cloud Computing Networks , Zetta bit Ethernet at Zetta Bit Rate Of Data Transfer Speed. Basically This Serializer Array Converts 64 bit parallel Data Array in to Serial Array Form on Transmitter Side and Transmission Done through High Speed Wireless Serial Communication Link and also Converts this Same Serial Array Data into Parallel Data Array on the Receiver Side by De-Serializer Array ASIC without any noise, also measure Very High Compressed Jitter Tolerance & Eye Diagram, Bit Error Rate through Analyzer. This LVDS Data SER-De-SER mainly used in High Speed Bus Communication Protocol Transceivers, Interface FPGA Add On Cards. The Process Of Design is Implemented through Verilog HDL / VHDL, Programming & Debugging Done Latest FPGA Board.

  13. Room-temperature macromolecular serial crystallography using synchrotron radiation

    Directory of Open Access Journals (Sweden)

    Francesco Stellato

    2014-07-01

    Full Text Available A new approach for collecting data from many hundreds of thousands of microcrystals using X-ray pulses from a free-electron laser has recently been developed. Referred to as serial crystallography, diffraction patterns are recorded at a constant rate as a suspension of protein crystals flows across the path of an X-ray beam. Events that by chance contain single-crystal diffraction patterns are retained, then indexed and merged to form a three-dimensional set of reflection intensities for structure determination. This approach relies upon several innovations: an intense X-ray beam; a fast detector system; a means to rapidly flow a suspension of crystals across the X-ray beam; and the computational infrastructure to process the large volume of data. Originally conceived for radiation-damage-free measurements with ultrafast X-ray pulses, the same methods can be employed with synchrotron radiation. As in powder diffraction, the averaging of thousands of observations per Bragg peak may improve the ratio of signal to noise of low-dose exposures. Here, it is shown that this paradigm can be implemented for room-temperature data collection using synchrotron radiation and exposure times of less than 3 ms. Using lysozyme microcrystals as a model system, over 40 000 single-crystal diffraction patterns were obtained and merged to produce a structural model that could be refined to 2.1 Å resolution. The resulting electron density is in excellent agreement with that obtained using standard X-ray data collection techniques. With further improvements the method is well suited for even shorter exposures at future and upgraded synchrotron radiation facilities that may deliver beams with 1000 times higher brightness than they currently produce.

  14. Does registration of serial MRI improve diagnosis of dementia?

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, Josephine; Kennedy, Jonathan; Barker, Suzie; Lehmann, Manja; Nordstrom, R.C.; Smith, Joseph R.; Rossor, Martin N.; Fox, Nick C. [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); Mitchell, L.A. [Austin Health, Radiology Department, Heidelberg (Australia); Melbourne University, Radiology Department, Melbourne (Australia); Bastos-Leite, Antonio J. [University of Oporto, Department of Medical Imaging, Faculty of Medicine, Oporto (Portugal); National Hospital for Neurology and Neurosurgery, Lysholm Department of Neuroradiology, London (United Kingdom); Frost, Chris [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); London School of Hygiene and Tropical Medicine, Department of Medical Statistics, London (United Kingdom); Garde, Ellen [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); Copenhagen University Hospital Hvidovre, Danish Research Centre for Magnetic Resonance, Hvidovre (Denmark)

    2010-11-15

    We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia. One hundred twenty subjects with clinical follow-up of at least 1 year with two scans were selected from a cognitive disorders clinic. Scans were reviewed as a single first scan (method A), two unregistered scans presented side-by-side (method B) and a registered pair (method C). Scans were presented to two neuroradiologists and a clinician together with approximate scan interval (if applicable) and age. Raters decided on a main and subtype diagnosis. There was no evidence that differences between methods (expressed as relative odds of a correct response) differed between reviewers (p = 0.17 for degenerative condition or not, p = 0.5 for main diagnosis, p = 0.16 for subtype). Accordingly, results were pooled over reviewers. For distinguishing normal/non-progressors from degenerative conditions, the proportions correctly diagnosed were higher with methods B and C than with A (p = 0.001, both tests). The difference between method B and C was not statistically significant (p = 0.18). For main diagnosis, the proportion of correct diagnoses were highest with method C for all three reviewers; however, this was not statistically significant comparing with method A (p = 0.23) or with method B (p = 0.16). For subtype diagnosis, there was some evidence that method C was better than method A (p = 0.01) and B (p = 0.048). Serial MRI and registration may improve visual diagnosis in dementia. (orig.)

  15. On the Performance of the Python Programming Language for Serial and Parallel Scientific Computations

    Directory of Open Access Journals (Sweden)

    Xing Cai

    2005-01-01

    Full Text Available This article addresses the performance of scientific applications that use the Python programming language. First, we investigate several techniques for improving the computational efficiency of serial Python codes. Then, we discuss the basic programming techniques in Python for parallelizing serial scientific applications. It is shown that an efficient implementation of the array-related operations is essential for achieving good parallel performance, as for the serial case. Once the array-related operations are efficiently implemented, probably using a mixed-language implementation, good serial and parallel performance become achievable. This is confirmed by a set of numerical experiments. Python is also shown to be well suited for writing high-level parallel programs.

  16. Serial fetal abdominal circumference measurements in predicting normal birth weight in gestational diabetes mellitus.

    LENUS (Irish Health Repository)

    Neff, Karl J

    2013-06-24

    To construct a clinical management matrix using serial fetal abdominal circumference measurements (ACMs) that will predict normal birth weight in pregnancies complicated by gestational diabetes (GDM) and reduce unnecessary ultrasound examination in women with GDM.

  17. Serial Min-max Decoding Algorithm Based on Variable Weighting for Nonbinary LDPC Codes

    Directory of Open Access Journals (Sweden)

    Zhongxun Wang

    2013-09-01

    Full Text Available In this paper, we perform an analysis on the min-max decoding algorithm for nonbinary LDPC(low-density parity-check codes and propose serial min-max decoding algorithm. Combining with the weighted processing of the variable node message, we propose serial min-max decoding algorithm based on variable weighting for nonbinary LDPC codes in the end. The simulation indicates that when the bit error rate is 10^-3,compared with serial min-max decoding algorithm ,traditional min-max decoding algorithm and traditional minsum algorithm ,serial min-max decoding algorithm based on variable weighting can offer additional coding gain 0.2dB、0.8dB and 1.4dB respectively in additional white Gaussian noise channel and under binary phase shift keying modulation.  

  18. Input- and Output-Specific Regulation of Serial Order Performance by Corticostriatal Circuits.

    Science.gov (United States)

    Rothwell, Patrick E; Hayton, Scott J; Sun, Gordon L; Fuccillo, Marc V; Lim, Byung Kook; Malenka, Robert C

    2015-10-21

    The serial ordering of individual movements into sequential patterns is thought to require synaptic plasticity within corticostriatal circuits that route information through the basal ganglia. We used genetically and anatomically targeted manipulations of specific circuit elements in mice to isolate the source and target of a corticostriatal synapse that regulates the performance of a serial order task. This excitatory synapse originates in secondary motor cortex, terminates on direct pathway medium spiny neurons in the dorsolateral striatum, and is strengthened by serial order learning. This experience-dependent and synapse-specific form of plasticity may sculpt the balance of activity in basal ganglia circuits during sequential movements, driving a disparity in striatal output that favors the direct pathway. This disparity is necessary for execution of responses in serial order, even though both direct and indirect pathways are active during movement initiation, suggesting dynamic modulation of corticostriatal circuitry contributes to the choreography of behavioral routines.

  19. Alur Kerja Tahap Produksi Karakter Animasi Serial 3D Menggunakan Perangkat Lunak Maxon Cinema 4D

    Directory of Open Access Journals (Sweden)

    Ardiyan

    2011-03-01

    Full Text Available 3D Animation serial for television needs have been showed in the national television program, especially fantasy theme and educational program for children. There are so many and sequential needs which tricked by instant and high-quality production so the work flow in creating 3D animation serial are facilitating the producers. The article will explain specifically how the software of Maxon Cinema 4D in process production in 3D animation serial. The article will also clarify and focus on how the work flow of Maxon Cinema 4D software in processing production and post-production stages. The writer does research including audio visual tutorial, end-result comparison and rendering time between some software, self-observation of work flow in creating 3D animation serial using Maxon Cinema 4D software and digital literature study (e-book.

  20. Nonverbal Short-Term Serial Order Memory in Autism Spectrum Disorder

    Science.gov (United States)

    2016-01-01

    To clarify the role of item and order memory in the serial recall of adults with autism spectrum disorder (ASD), we carried out 2 experiments in which adults with ASD and comparison participants matched on chronological age and verbal IQ saw sequences of 7 dots appear sequentially in a 3 × 4 grid. In Experiment 1 (serial recall), they had to recall the locations and the presentation order of the dots by tapping locations on an empty grid. In Experiment 2, (order reconstruction) the studied dots were provided at test and participants had to touch them in their order of appearance at study. Experiment 1 revealed diminished item and order recall in the ASD group; Experiment 2 revealed diminished order recall only when verbal IQ was controlled. The results support the view that people with ASD have particular difficulty with serial order recall but may use their language ability to achieve better serial recall performance. PMID:27732024

  1. LHCb: SPECS: a Serial Protocol for the Experiment Control System of LHCb

    CERN Multimedia

    Charlet, D

    2007-01-01

    The SPECS is a single master, multi slave serial bus. It communicates between an unique master and up to 32 slaves (limit fixed by the address range), at a 10 MHz rate, thanks to 4 different unidirectional lines.

  2. 3-PRS serial-parallel machine tool error calibration and parameter identification

    Institute of Scientific and Technical Information of China (English)

    ZHAO Jun-wei; DAI Jun; HUANG Jun-jie

    2009-01-01

    3-PRS serial-parallel machine tool consists of a 3-degree-of-freedom (DOF) implementation platform and a 2-DOF X-Y platform. The error modeling and parameter identification methods were deduced based on 3-PRS serial-parallel machine tool. 3-PRS serial-parallel machine tool was researched, and the mechanism of error analysis, modeling, identification of error parameters and measurement equipment for the use of agency error of measurement were conducted. In order to achieve the geometric parameters calibration and error compensation of the serial-parallel machine tool, the nominal structural parameters of the controller was adjusted by identifying the structure of the machine tool. With the establishment of a vector space size chain, we can do the error analysis, error modeling, error measurement and error compensation can be done.

  3. Paths to destruction: the lives and crimes of two serial killers.

    Science.gov (United States)

    Wolf, Barbara C; Lavezzi, Wendy A

    2007-01-01

    Although research into the phenomenon of serial murder has revealed that serial killers frequently do not fit the initially described paradigm in terms of their physical and psychological profiles, backgrounds, and motives to kill, the media continues to sensationalize the figures of such killers and the investigators who attempt to analyze them on the basis of aspects of their crimes. Although the so-called "typical" profile of the serial murderer has proven accurate in some instances, in many other cases the demographics and behaviors of these killers have deviated widely from the generalized assumptions. This report details two unusual cases in which five and eight murders were committed in upstate New York. The lives and crimes of these offenders illustrate the wide spectrum of variations in the backgrounds, demographics, motivations, and actions witnessed among serial murderers, and highlight the limitations and dangers of profiling based on generalities.

  4. Consistent Estimation of Order for Regression in the Presence of Serial Correlation and Heteroscedasticity

    Institute of Scientific and Technical Information of China (English)

    CHEN Min; WU Guo-fu; QI Quan-yue

    2001-01-01

    In this paper, we consider a multiple regression model in the presence of serial correlation and heteroscedasticity. We establish the convergence rate of an efficient estimation of autoregressive coefficients suggested by Harvey and Robison (1988). We propose a method to identify order of serial correlation data and prove that it is of strong consistency. The simulation reports show that the method of identifying order is available.

  5. Il ruolo della neurocriminologia nella costruzione di un profilo criminologico dell’omicida seriale

    Directory of Open Access Journals (Sweden)

    Samuel Occhi

    2015-09-01

    The purpose of this article is to analyse modalities permitting the investigators to determine the profile of a serial killer according to their neurocriminological characteristics. The phenomenon of serial killing is described in the introduction. This descriptive analysis takes into account the typically used classifications, the criminogenesis, and the criminodynamics. In the second part, neurocriminological variables associated with this criminal profile are reviewed. Among them, the main variables are genetics and brain functioning.

  6. Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers

    DEFF Research Database (Denmark)

    Emiliyanov, Grigoriy Andreev; Høiby, Poul E.; Pedersen, Lars H.

    2013-01-01

    We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows...... for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated....

  7. Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers

    Directory of Open Access Journals (Sweden)

    Lars H. Pedersen

    2013-03-01

    Full Text Available We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated.

  8. Selective serial multi-antibody biosensing with TOPAS microstructured polymer optical fibers.

    Science.gov (United States)

    Emiliyanov, Grigoriy; Høiby, Poul E; Pedersen, Lars H; Bang, Ole

    2013-03-08

    We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated.

  9. TESTING SERIAL CORRELATION IN SEMIPARAMETRIC VARYING COEFFICIENT PARTIALLY LINEAR ERRORS-IN-VARIABLES MODEL

    Institute of Scientific and Technical Information of China (English)

    Xuemei HU; Feng LIU; Zhizhong WANG

    2009-01-01

    The authors propose a V_(N,P) test statistic for testing finite-order serial correlation in a semiparametric varying coefficient partially linear errors-in-variables model. The test statistic is shown to have asymptotic normal distribution under the null hypothesis of no serial correlation. Some Monte Carlo experiments are conducted to examine the finite sample performance of the proposed V_(N,P) test statistic. Simulation results confirm that the proposed test performs satisfactorily in estimated size and power.

  10. ON-DEMAND SERIAL DILUTION USING QUANTIZED NANO/PICOLITER-SCALE DROPLETS

    Energy Technology Data Exchange (ETDEWEB)

    Jambovane, Sachin R.; Prost, Spencer A.; Sheen, Allison M.; Magnuson, Jon K.; Kelly, Ryan T.

    2014-10-29

    This paper describes a fully automated droplet-based microfluidic device for on-demand serial dilution that is capable of achieving a dilution ratio of >6000 (concentration ranges from 1 mM to 160nM) over 35 nanoliter-scale droplets. This serial diluter can be applied to high throughput and label-free kinetic assays by integrating with our previously developed on-demand droplet-based microfluidic with mass spectrometry detection.

  11. Mortgage Foreclosure and Health Disparities: Serial Displacement as Asset Extraction in African American Populations

    OpenAIRE

    Saegert, Susan; Fields, Desiree; Libman, Kimberly

    2011-01-01

    In this paper we offer a conceptualization of mortgage foreclosure as serial displacement by highlighting the current crisis in the context of historically repeated extraction of capital—economic, social, and human—from communities defined at different scales: geographically, socially, and that of embodied individuals. We argue that serial displacement is the loss of capital, physical resources, social integration and collective capacity, and psycho-social resources at each of these scales, w...

  12. Modified serial extraction treatment in a patient with congenitally missing lower second premolars

    OpenAIRE

    Al Hummayani, Fadia Mohammed

    2015-01-01

    Serial extraction is a sequential plan of premature removal of one or more deciduous teeth in order to improve the alignment of permanent teeth and then removal of permanent teeth to maintain the proper ratio between tooth size and arch size. The aim of this case report was to present a case treated successfully with a modified serial extraction protocol in the lower arch because the patient had congenitally missing lower second premolars with severe crowding. The treatment consisted of selec...

  13. Serial optical communications and ultra-fast optical signal processing of Tbit/s data signals

    DEFF Research Database (Denmark)

    Oxenløwe, Leif Katsuo; Galili, Michael; Hu, Hao;

    2010-01-01

    This paper reviews our recent advances in ultra-high speed serial optical communications. It describes Tbit/s optical signal processing and various materials allowing for this, as well as network scenarios embracing this technology......This paper reviews our recent advances in ultra-high speed serial optical communications. It describes Tbit/s optical signal processing and various materials allowing for this, as well as network scenarios embracing this technology...

  14. A proteomic analysis during serial subculture and osteogenic differentiation of human mesenchymal stem cell.

    Science.gov (United States)

    Sun, Hyun Jin; Bahk, Young Yil; Choi, Yon Rak; Shim, Jung Hye; Han, Seung Hwan; Lee, Jin Woo

    2006-11-01

    Although previous studies have reported the effects of extensive subculturing on proliferation rates and osteogenic potential of human mesenchymal stem cells (hMSCs), the results remain controversial. The aim of our study was to characterize the proliferation and osteogenic potential of hMSCs during serial subculture, and also to identify proteins that are differentially regulated in hMSCs during serial subculture and osteogenic differentiation using proteome analysis. Here we show that the proliferation and osteogenic capacity of hMSCs decrease during serial subculturing. Several proteins were shown to be differentially regulated during serial subculture; among these the expression of T-complex protein 1 alpha subunit (TCP-1alpha), a protein known to be associated with cell proliferation, cell cycle, morphological changes, and apoptosis, gradually decreased during serial subculture. Among proteins that were differentially regulated during osteogenic differentiation, chloride intracellular channel 1 (CLIC1) was downregulated only during the early passages eukaryotic translation elongation factor, and acidic ribosomal phosphoprotein P0 was downregulated during the middle passages, while annexin V, LIM, and SH3 domain protein 1 (LASP-1), and 14-3-3 protein gamma (YWHAG) were upregulated during the later passage. These studies suggest that differentially regulated passage-specific proteins may play a role in the decrease of osteogenic differentiation potential under serial subculturing.

  15. Effect of Different Attentional Instructions on the Acquisition of a Serial Movement Task

    Directory of Open Access Journals (Sweden)

    Mei Teng Woo

    2014-12-01

    Full Text Available Recent research in attentional focus of instruction has predominantly over-emphasized the investigation of discrete and continuous skills rather than serial skills. The purpose of this study was therefore to examine the effect of different attentional focus instructions on learning a serial skill task (i.e., taekwondo routine in novice learners. It was predicted that the use of movement outcome instructions could enhance the learning of a serial skill as previously supported in studies examining the acquisition of discrete and continuous skills. Thirteen female participants were recruited for this study and were assigned to either movement form condition - control group (n = 7 or movement outcome condition – treatment group (n = 6. All participants underwent 12 practice sessions over an 8-week period with their respective instructional conditions with each session lasting 30 minutes. Video recording of the serial skill tasks (hand techniques, kicking techniques and 10-step routine were captured at “the-twelfth-training session”, “after 1-week”, and “after 1-month”. It was found that more participants in the treatment group obtained a higher score in all three serial skill tasks, especially in Mastery component of ‘Kicking’ techniques at ‘after 1-week’ (p < 0.05, r = 0.57. This study suggested that movement outcome instructions have positive medium effect on balance control for serial skill task, especially in kicking actions.

  16. Effect of different attentional instructions on the acquisition of a serial movement task.

    Science.gov (United States)

    Woo, Mei Teng; Chow, Jia Yi; Koh, Michael

    2014-12-01

    Recent research in attentional focus of instruction has predominantly over-emphasized the investigation of discrete and continuous skills rather than serial skills. The purpose of this study was therefore to examine the effect of different attentional focus instructions on learning a serial skill task (i.e., taekwondo routine) in novice learners. It was predicted that the use of movement outcome instructions could enhance the learning of a serial skill as previously supported in studies examining the acquisition of discrete and continuous skills. Thirteen female participants were recruited for this study and were assigned to either movement form condition - control group (n = 7) or movement outcome condition - treatment group (n = 6). All participants underwent 12 practice sessions over an 8-week period with their respective instructional conditions with each session lasting 30 minutes. Video recording of the serial skill tasks (hand techniques, kicking techniques and 10-step routine) were captured at "the-twelfth-training session", "after 1-week", and "after 1-month". It was found that more participants in the treatment group obtained a higher score in all three serial skill tasks, especially in Mastery component of 'Kicking' techniques at 'after 1-week' (p skill task, especially in kicking actions. Key PointsMovement outcome (MO) instructions have a positive impact on learning a serial task, especially in kicking actions.More functional coordination during movement executions for MO participants.Benefits for MO instructions may be individual specific.

  17. Keeping an eye on serial order: Ocular movements bind space and time.

    Science.gov (United States)

    Rinaldi, Luca; Brugger, Peter; Bockisch, Christopher J; Bertolini, Giovanni; Girelli, Luisa

    2015-09-01

    The present study examined whether traveling through serially-ordered verbal memories exploits overt visuospatial attentional resources. In a three-phase behavioral study, five single-digits were presented sequentially at one spatial location in phase 1, while recognition and verbal recall were tested in phases 2 and 3, respectively. Participants' spontaneous eye movements were registered along with the verbal responses. Results showed that the search and the retrieval of serially-ordered information were mediated by spontaneous ocular movements. Specifically, recognizing middle items of the memorized sequence required longer inspection times and, importantly, a greater involvement of overt attentional resources, than recognizing the serially first-presented item and, to a lesser extent, the last-presented item. Moreover, serial order was found to be spatially encoded from left-to-right, as eye position during vocal responses deviated the more to the right, the later the serial position of the retrieved item in the sequence. These findings suggest that overt spatial attention mediates the scanning of serial order representation.

  18. Uncovering the genetic basis of attenuation in Marek’s disease virus

    Science.gov (United States)

    While in vitro serial passage of Marek’s disease virus (MDV) is a proven method to attenuate MDV strains, the underlying genetic changes responsible for attenuation remains unknown. To identify candidate genes and mutations, a virulent MDV generated from an Md5-containing BAC clone was serially pass...

  19. Managing Electronic Serials: Essays Based on the ALCTS Electronic Serials Institutes 1997-1999. ALCTS Papers on Library Technical Services & Collections, No. 9.

    Science.gov (United States)

    Bluh, Pamela M., Ed.

    If managed well, electronic journals (e-journals) can be extremely efficient, saving money and space while improving access and speeding information delivery. With the help of the Internet, e-journals can also make library collections more accessible to both users and staff. Covering the process of managing electronic serials from licensing,…

  20. Participação das enfermeiras no processo de implantação de práticas obstétricas humanizadas na maternidade Alexander Fleming (1998-2004 Participación de las enfermeras en el proceso de implementación de prácticas de obstetricia humanizada en la maternidade Alexander Fleming (1998-2004 Participation of nurses in the process of implementation of obstetrical practices in the maternity humanized Alexander Fleming (1998-2004

    Directory of Open Access Journals (Sweden)

    Jane Márcia Progianti

    2012-09-01

    Full Text Available Estudo de natureza histórico-social cujo objetivo é analisar o processo de inserção das enfermeiras na assistência ao parto e as lutas dessas profissionais para implantar as práticas obstétricas humanizadas na Maternidade Alexander Fleming. Utilizou-se a história oral temática como método. As etapas da análise foram: ordenação, classificação e triangulação dos dados. Para sustentação da análise, utilizamos os conceitos de campo, habitus, poder simbólico e capital, de Pierre Bourdieu. Os resultados apontaram que a inserção das enfermeiras na assistência ao parto ocorreu mediante a lotação de recursos humanos para este projeto e de uma capacitação intensiva. Ao serem inseridas no centro obstétrico, as enfermeiras criaram um espaço próprio de atuação e elaboraram um protocolo assistencial. Concluímos que as estratégias de luta simbólica utilizadas pelas enfermeiras contribuíram para a conquista de espaços que as distinguiram no campo pelo desenvolvimento de práticas humanizadas que estavam de acordo com seu habitus.Se trata de un estudio de carácter histórico y social cuya finalidad es analizar el proceso de inserción de las enfermeras en el momento de la entrega y la lucha de estos profesionales para implementar las prácticas obstétricas humanizadas en la Maternidade Alexander Fleming. El método utilizado fue la historia oral temática. Los pasos del análisis fueron: ordenación, clasificación y triangulación de los datos. Para sustentación del análisis se utilizó los conceptos de campo, habitus, poder simbólico y capital, de Pierre Bourdieu. Los resultados mostraron que la inclusión de las enfermeras en la atención del parto se produjo a través de la capacidad de recursos humanos para este proyecto y de un entrenamiento intensivo. Al ser insertado en el centro obstétrico, las enfermeras han creado su propio espacio para la acción y han desarrollado un protocolo de atención. Concluimos que