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Sample records for alendronate improve metaphyseal

  1. Alendronate

    Science.gov (United States)

    ... follow these instructions: You must take alendronate just after you get out of bed in the morning, before ... cup (2 ounces [60 mL]) of plain water after you take alendronate solution. Never take alendronate tablets or ...

  2. Whole body vibration exercise improves body balance and walking velocity in postmenopausal osteoporotic women treated with alendronate: Galileo and Alendronate Intervention Trail (GAIT).

    Science.gov (United States)

    Iwamoto, J; Sato, Y; Takeda, T; Matsumoto, H

    2012-09-01

    A randomized controlled trial was conducted to determine the effect of 6 months of whole body vibration (WBV) exercise on physical function in postmenopausal osteoporotic women treated with alendronate. Fifty-two ambulatory postmenopausal women with osteoporosis (mean age: 74.2 years, range: 51-91 years) were randomly divided into two groups: an exercise group and a control group. A four-minute WBV exercise was performed two days per week only in the exercise group. No exercise was performed in the control group. All the women were treated with alendronate. After 6 months of the WBV exercise, the indices for flexibility, body balance, and walking velocity were significantly improved in the exercise group compared with the control group. The exercise was safe and well tolerated. The reductions in serum alkaline phosphatase and urinary cross-linked N-terminal telopeptides of type I collagen during the 6-month period were comparable between the two groups. The present study showed the benefit and safety of WBV exercise for improving physical function in postmenopausal osteoporotic women treated with alendronate.

  3. Risedronate improves bone architecture and strength faster than alendronate in ovariectomized rats on a low-calcium diet.

    Science.gov (United States)

    Yano, Tetsuo; Yamada, Mei; Konda, Tomoyuki; Shiozaki, Makoto; Inoue, Daisuke

    2014-11-01

    Clinical evidence suggests that, compared with alendronate, risedronate reduces fracture risk faster and more potently, with less bone mass gain. We tested the hypothesis that risedronate improves bone quality faster than alendronate using calcium-deficient, ovariectomized (OVX) rats. Female Sprague-Dawley rats at 24 weeks of age were divided into sham-operated and OVX groups and fed a low-calcium (0.05%) diet under paired feeding. After 12 weeks, OVX rats were divided into five groups and treated with vehicle, risedronate (3.5 and 17.5 μg/kg/week, s.c.) or alendronate (7 and 35 μg/kg/week, s.c.). Rats were killed 6-8 weeks later and the bone architecture and strength of the left femur were evaluated by micro-computed tomography and a three-point bending test. Trabecular bone mineral density (BMD), number and thickness were significantly lower in OVX rats than in the sham-operated group. Cortical BMD, bone area (Ct.Ar), and thickness (Ct.Th) were similarly decreased. Risedronate significantly improved Ct.Ar (+8%) and Ct.Th (+9%) at 6 weeks, while alendronate only caused a significant improvement in Ct.Ar (+8% at 6 weeks) and only at the higher dose. At 8 weeks, both risedronate and alendronate significantly increased trabecular BMD compared with the vehicle. Bone strength parameters showed a significant correlation between Ct.Ar and Ct.Th. Risedronate significantly improved maximum load at 6 weeks, while alendronate failed to produce any significant changes. Our results suggest that risedronate is superior to alendronate at improving cortical bone architecture and strength, and that enhanced bone quality partly accounts for risedronate's efficacy.

  4. Improvement of cancellous bone microstructure in patients on teriparatide following alendronate pretreatment.

    Science.gov (United States)

    Fahrleitner-Pammer, Astrid; Burr, David; Dobnig, Harald; Stepan, Jan J; Petto, Helmut; Li, Jiliang; Krege, John H; Pavo, Imre

    2016-08-01

    An increase in procollagen type I amino-terminal propeptide (PINP) early after teriparatide initiation was shown to correlate with increased lumbar spine areal BMD and is a good predictor of the anabolic response to teriparatide. Few data exist correlating PINP and bone microstructure, and no data exist in patients on teriparatide following prior potent antiresorptive treatment. This exploratory analysis aimed to investigate the effects of teriparatide on cancellous bone microstructure and correlations of bone markers with microstructure in alendronate-pretreated patients. This was a post hoc analysis of changes in bone markers and three-dimensional indices of bone microstructure in paired iliac crest biopsies from a prospective teriparatide treatment study in postmenopausal women with osteoporosis who were either treatment-naïve (TN, n=16) or alendronate-pretreated (ALN, n=29) at teriparatide initiation. Teriparatide (20μg/day) was given for 24months; biopsies were taken at baseline and endpoint, and serum concentrations of PINP and type 1 collagen cross-linked C-telopeptide (βCTX) were measured at intervals up to 24months. In the TN and ALN groups, respectively, mean (SD) increases in three-dimensional bone volume/tissue volume were 105 (356)% (P=0.039) and 55 (139)% (Pmicrostructure. However, 12-month changes in biochemical bone markers correlated significantly with improvements in bone volume/tissue volume, r=0.502 (Pmicrostructure improved with teriparatide therapy irrespective of prior antiresorptive use.

  5. Alendronate Can Improve Bone Alterations in Experimental Diabetes by Preventing Antiosteogenic, Antichondrogenic, and Proadipocytic Effects of AGEs on Bone Marrow Progenitor Cells

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    Sara Rocío Chuguransky

    2016-01-01

    Full Text Available Bisphosphonates such as alendronate are antiosteoporotic drugs that inhibit the activity of bone-resorbing osteoclasts and secondarily promote osteoblastic function. Diabetes increases bone-matrix-associated advanced glycation end products (AGEs that impair bone marrow progenitor cell (BMPC osteogenic potential and decrease bone quality. Here we investigated the in vitro effect of alendronate and/or AGEs on the osteoblastogenic, adipogenic, and chondrogenic potential of BMPC isolated from nondiabetic untreated rats. We also evaluated the in vivo effect of alendronate (administered orally to rats with insulin-deficient Diabetes on long-bone microarchitecture and BMPC multilineage potential. In vitro, the osteogenesis (Runx2, alkaline phosphatase, type 1 collagen, and mineralization and chondrogenesis (glycosaminoglycan production of BMPC were both decreased by AGEs, while coincubation with alendronate prevented these effects. The adipogenesis of BMPC (PPARγ, intracellular triglycerides, and lipase was increased by AGEs, and this was prevented by coincubation with alendronate. In vivo, experimental Diabetes (a decreased femoral trabecular bone area, osteocyte density, and osteoclastic TRAP activity; (b increased bone marrow adiposity; and (c deregulated BMPC phenotypic potential (increasing adipogenesis and decreasing osteogenesis and chondrogenesis. Orally administered alendronate prevented all these Diabetes-induced effects on bone. Thus, alendronate could improve bone alterations in diabetic rats by preventing the antiosteogenic, antichondrogenic, and proadipocytic effects of AGEs on BMPC.

  6. Improvement of cancellous bone microstructure in patients on teriparatide following alendronate pretreatment.

    Science.gov (United States)

    Fahrleitner-Pammer, Astrid; Burr, David; Dobnig, Harald; Stepan, Jan J; Petto, Helmut; Li, Jiliang; Krege, John H; Pavo, Imre

    2016-08-01

    An increase in procollagen type I amino-terminal propeptide (PINP) early after teriparatide initiation was shown to correlate with increased lumbar spine areal BMD and is a good predictor of the anabolic response to teriparatide. Few data exist correlating PINP and bone microstructure, and no data exist in patients on teriparatide following prior potent antiresorptive treatment. This exploratory analysis aimed to investigate the effects of teriparatide on cancellous bone microstructure and correlations of bone markers with microstructure in alendronate-pretreated patients. This was a post hoc analysis of changes in bone markers and three-dimensional indices of bone microstructure in paired iliac crest biopsies from a prospective teriparatide treatment study in postmenopausal women with osteoporosis who were either treatment-naïve (TN, n=16) or alendronate-pretreated (ALN, n=29) at teriparatide initiation. Teriparatide (20μg/day) was given for 24months; biopsies were taken at baseline and endpoint, and serum concentrations of PINP and type 1 collagen cross-linked C-telopeptide (βCTX) were measured at intervals up to 24months. In the TN and ALN groups, respectively, mean (SD) increases in three-dimensional bone volume/tissue volume were 105 (356)% (P=0.039) and 55 (139)% (P<0.005) and trabecular thickness 30.4 (30)% (P<0.001) and 30.8 (53)% (P<0.001). No significant changes were observed in trabecular number or separation. In the ALN patients, 3-month change of neither PINP nor βCTX correlated with indices of cancellous bone microstructure. However, 12-month changes in biochemical bone markers correlated significantly with improvements in bone volume/tissue volume, r=0.502 (P<0.01) and r=0.378 (P<0.05), trabecular number, r=0.559 (P<0.01) and r=0.515 (P<0.01), and reduction of trabecular separation, r=-0.432 (P<0.05) and r=-0.530 (P<0.01), for PINP and βCTX, respectively. We conclude that cancellous bone microstructure improved with teriparatide therapy

  7. Metaphysically Reductive Causation

    OpenAIRE

    Hall, Edward J; Paul, L. A.

    2013-01-01

    There are, by now, many rival, sophisticated philosophical accounts of causation that qualify as ‘metaphysically reductive’. A good thing: these collective efforts have vastly improved our understanding of causation over the last 30 years or so. They also put us in an excellent position to reflect on some central methodological questions: What exactly is the point of offering a metaphysical reduction of causation? What philosophical scruples ought to guide the pursuit of such a reduction? Fin...

  8. Linhas escleróticas metafisárias em crianças e adolescentes em uso de alendronato Sclerotic metaphyseal lines in children and adolescents treated with alendronate

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    Érika C.C. Silva

    2010-06-01

    Full Text Available INTRODUÇÃO: Os bisfosfonatos inibem a reabsorção óssea pela interferência na ação dos osteoclastos. Dentre os efeitos adversos, as linhas escleróticas em metáfise de ossos longos são descritas como principal alteração radiográfica na faixa etária pediátrica. OBJETIVO: Avaliar a frequência de alterações radiográficas causadas pelo alendronato utilizado em crianças e adolescentes com baixa densidade óssea ou calcinose. PACIENTES E MÉTODOS: Foi realizado um estudo do tipo coorte retrospectiva analisando-se prontuários de 21 pacientes que fizeram uso de alendronato semanal por no mínimo 10 meses. Os pacientes realizaram radiografias de ossos longos antes do início do alendronato e aproximadamente um ano após o seu uso. RESULTADOS: Onze pacientes (52,3% apresentaram linhas escleróticas em metáfise dos ossos longos. A localização mais frequente foi em tíbia (8/11 pacientes, seguida de fêmur (7/11, úmero (6/11, rádio (4/11, ulna (3/11 e fíbula (2/11. Nenhum paciente apresentou regress��o das alterações radiográficas durante o tempo de evolução (até 1,1 ano após a suspensão do alendronato. CONCLUSÃO: Se usado com critério, o alendronato é seguro e as alterações radiográficas não mostraram ter um significado mais importante.INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radiographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients

  9. On the absorption of alendronate in rats.

    Science.gov (United States)

    Lin, J H; Chen, I W; deLuna, F A

    1994-12-01

    Alendronate is an antiosteolytic agent under investigation for the treatment of a number of bone disorders. Since the compound is a zwitterion with five pKa values and is completely ionized in the intestine at the physiological pH, absorption is poor; less than 1% of an oral dose is available systemically in rats. In the present studies, absorption was found to be predominantly in the upper part of the small intestine. Administration of buffered solutions of alendronate (pH 2-11) did not improve absorption. Whereas food markedly impaired the absorption of alendronate, EDTA enhanced absorption in a dose-dependent manner. Pretreatment of rats with ulcerogenic agents, mepirizole, acetylsalicylic acid, or indomethacin, resulted in a 3-7-fold increase in the oral absorption of alendronate. The absorption of phenol red, added as an indicator of intestinal tissue damage, was also increased in rats with experimental peptic ulcers. The enhanced absorption of alendronate observed in rats with experimental peptic ulcers was attributed to the alteration of the integrity of the intestinal membrane. PMID:7891304

  10. Metaphyseal giant cell tumor

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, L.F.; Hemais, P.M.P.G.; Aymore, I.L.; Carmo, M.C.R. do; Cunha, M.E.P.R. da; Resende, C.M.C.

    Three cases of metaphyseal giant cell tumor are presented. A review of the literature is done, demostrating the lesion is rare and that there are few articles about it. Age incidence and characteristics of the tumor are discussed.

  11. Metaphyseal giant cell tumor

    International Nuclear Information System (INIS)

    Three cases of metaphyseal giant cell tumor are presented. A review of the literature is done, demostrating the lesion is rare and that there are few articles about it. Age incidence and characteristics of the tumor are discussed. (Author)

  12. Effect of heparin and alendronate coating on titanium surfaces on inhibition of osteoclast and enhancement of osteoblast function

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Ho-Jin; Yun, Young-Pil [Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Han, Choong-Wan; Kim, Min Sung [Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Institute of Oral Biology, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Kim, Sung Eun; Bae, Min Soo [Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Kim, Gyu-Tae; Choi, Yong-Suk; Hwang, Eui-Hwan [Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Institute of Oral Biology, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Lee, Joon Woo [Department of Technology Commercialization Information, Korea Institute of Science and Technology Information (KISTI), 66, Hoegi-ro, Dongdaemun-gu, Seoul 130-741 (Korea, Republic of); Lee, Jin-Moo; Lee, Chang-Hoon [Department of Oriental Gynecology, College of Oriental Medicine, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Kim, Duck-Su [Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Kwon, Il Keun, E-mail: kwoni@khu.ac.kr [Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Institute of Oral Biology, Kyung Hee University, Seoul 130-701 (Korea, Republic of)

    2011-09-23

    Highlights: {yields} We examine bone metabolism of engineered alendronate attached to Ti surfaces. {yields} Alendronate-immobilized Ti enhances activation of osteoblast differentiation. {yields} Alendronate-immobilized Ti inhibits osteoclast differentiation. {yields} Alendronate-immobilized Ti may be a bioactive implant with dual functions. -- Abstract: The failure of orthopedic and dental implants has been attributed mainly to loosening of the implant from host bone, which may be due to weak bonding of the implant material to bone tissue. Titanium (Ti) is used in the field of orthopedic and dental implants because of its excellent biocompatibility and outstanding mechanical properties. Therefore, in the field of materials science and tissue engineering, there has been extensive research to immobilize bioactive molecules on the surface of implant materials in order to provide the implants with improved adhesion to the host bone tissue. In this study, chemically active functional groups were introduced on the surface of Ti by a grafting reaction with heparin and then the Ti was functionalized by immobilizing alendronate onto the heparin-grafted surface. In the MC3T3-E1 cell osteogenic differentiation study, the alendronate-immobilized Ti substrates significantly enhanced alkaline phosphatase activity (ALP) and calcium content. Additionally, nuclear factor kappa B ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells was inhibited with the alendronate-immobilized Ti as confirmed by TRAP analysis. Real time PCR analysis showed that mRNA expressions of osteocalcin and osteopontin, which are markers for osteogenesis, were upregulated in MC3T3-E1 cells cultured on alendronate-immobilized Ti. The mRNA expressions of TRAP and Cathepsin K, markers for osteoclastogenesis, in RAW264.7 cells cultured on alendronate-immobilized Ti were down-regulated. Our study suggests that alendronate-immobilized Ti may be a bioactive implant with dual functions to enhance

  13. Effect of heparin and alendronate coating on titanium surfaces on inhibition of osteoclast and enhancement of osteoblast function

    International Nuclear Information System (INIS)

    Highlights: → We examine bone metabolism of engineered alendronate attached to Ti surfaces. → Alendronate-immobilized Ti enhances activation of osteoblast differentiation. → Alendronate-immobilized Ti inhibits osteoclast differentiation. → Alendronate-immobilized Ti may be a bioactive implant with dual functions. -- Abstract: The failure of orthopedic and dental implants has been attributed mainly to loosening of the implant from host bone, which may be due to weak bonding of the implant material to bone tissue. Titanium (Ti) is used in the field of orthopedic and dental implants because of its excellent biocompatibility and outstanding mechanical properties. Therefore, in the field of materials science and tissue engineering, there has been extensive research to immobilize bioactive molecules on the surface of implant materials in order to provide the implants with improved adhesion to the host bone tissue. In this study, chemically active functional groups were introduced on the surface of Ti by a grafting reaction with heparin and then the Ti was functionalized by immobilizing alendronate onto the heparin-grafted surface. In the MC3T3-E1 cell osteogenic differentiation study, the alendronate-immobilized Ti substrates significantly enhanced alkaline phosphatase activity (ALP) and calcium content. Additionally, nuclear factor kappa B ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells was inhibited with the alendronate-immobilized Ti as confirmed by TRAP analysis. Real time PCR analysis showed that mRNA expressions of osteocalcin and osteopontin, which are markers for osteogenesis, were upregulated in MC3T3-E1 cells cultured on alendronate-immobilized Ti. The mRNA expressions of TRAP and Cathepsin K, markers for osteoclastogenesis, in RAW264.7 cells cultured on alendronate-immobilized Ti were down-regulated. Our study suggests that alendronate-immobilized Ti may be a bioactive implant with dual functions to enhance osteoblast

  14. The Everyday Condition of Metaphysics

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    Ştefan Afloroaei

    2010-12-01

    Full Text Available The question I intend to answer is whether one can speak of a tacit metaphysics, not expressed conceptually, but nevertheless common. If the answer is positive and providing that it is specific to day-to-day life, such metaphysics may be called everyday metaphysics. To this end, I review the meaning of everyday life and its ambivalent character. Next, I present several milestones in the debate on the subject, from authors who have focused on a kind of usual, common or ‘natural’ metaphysics. Lastly, I formulate the idea under consideration, namely that everyday life implies or underlies a certain metaphysics. I note that it is an implicit metaphysics – not expressed formally – and rather free. Embraced in experience with a certain degree of freedom, it is recognisable by means of certain representations active in our mind, by the manner of speaking or of understanding and by the common forms of expression. Its vibrancy, concrete and relaxed character makes it highly evocative of the mental life of an era. It ensures a truly essential difference in our everyday mode of being.

  15. Temporal Platonic Metaphysics

    CERN Document Server

    Mikovic, A

    2009-01-01

    In this essay we describe a platonic metaphysics where time is a fundamental idea such that the passage of time is independent of observers and the laws of physics. Furthermore, time serves to distinguish between a real and an abstract universe, where a real universe is an appropriatelly ordered set of ideas in time, while an abstract universe is such a set outside of time. We allow for non-computable and non-mathematical ideas to be part of our model of the universe in order to include intelligent observers. The part of the universe which can be described by mathematics corresponds to a mathematical structure in Tegmark's sense, while the non-mathematical part can be described by a human language. We describe the mind-brain connection in our framework, and show that it resolves the problem of obtaining abstract knowledge in platonism. We briefly discuss how different interpretations of Quantum Mechanics can be implemented in our framework and point out some physics implications, most notably that the time tr...

  16. Godel's Incompleteness Theorems and Platonic Metaphysics

    CERN Document Server

    Mikovic, Aleksandar

    2015-01-01

    We argue by using Godel's incompletness theorems in logic that platonism is the best metaphysics for science. This is based on the fact that a natural law in a platonic metaphysics represents a timeless order in the motion of matter, while a natural law in a materialistic metaphysics can be only defined as a temporary order which appears at random in the chaotic motion of matter. Although a logical possibility, one can argue that this type of metaphysics is highly implausible. Given that mathematics fits naturally within platonism, we conclude that a platonic metaphysics is more preferable than a materialistic metaphysics.

  17. Ayer's critique of metaphysics: Metaphysics as dead end of philosophy

    OpenAIRE

    Altuner, İlyas

    2011-01-01

    Metaphysics, which is mentioned as the highest science by Aristotle, has lost its property of the queen of sciences more and more, afterwards it has been denied wherefore philosophy had been reduced to language analysis by philosophers in the Vienna Circle. Ayer has rejected metaphysics and he has argued that it had to be eliminated from philosophy because it was not be able to adapt to verifiability principle. Ayer’s purpose of verifiability is that to be proved something by experiment and o...

  18. Ayer's critique of metaphysics: Metaphysics as dead end of philosophy

    Directory of Open Access Journals (Sweden)

    İlyas Altuner

    2011-08-01

    Full Text Available Metaphysics, which is mentioned as the highest science by Aristotle, has lost its property of the queen of sciences more and more, afterwards it has been denied wherefore philosophy had been reduced to language analysis by philosophers in the Vienna Circle. Ayer has rejected metaphysics and he has argued that it had to be eliminated from philosophy because it was not be able to adapt to verifiability principle. Ayer’s purpose of verifiability is that to be proved something by experiment and observation. This, with Wittgensteinian statement, is to say drawing the picture of meaning or fact.

  19. Metaphysics in Education after Hutchins and Dewey.

    Science.gov (United States)

    Arcilla, Rene Vincente

    1991-01-01

    The article discusses whether education should promote metaphysical questioning and speculation, noting the arguments of Robert Hutchins and John Dewey in the 1930s. It suggests that metaphysical questioning and meditative responses be part of education. (SM)

  20. The Scientific Metaphysics of Charles S. Peirce

    DEFF Research Database (Denmark)

    Sørensen, Bent; Thellefsen, Torkild Leo

    scientific results and conceptions of his time, but also, like Immanuel Kant, to set metaphysics on the path of a science. This collection of articles investigates central themes and difficulties in the metaphysics of Peirce - some of the articles clarify aspects of his metaphysics, others also show...

  1. Metaphyseal bands in osteogenesis imperfecta

    International Nuclear Information System (INIS)

    An increasing number of patients with osteogenesis imperfecta are undergoing pamidronate therapy to prevent the incidence of fragility fractures. The authors herein report a child aged 3 years who received five cycles of pamidronate, resulting in metaphyseal bands, known as “zebra lines.”

  2. Hip fracture protection by alendronate treatment in postmenopausal women with osteoporosis: a review of the literature

    Directory of Open Access Journals (Sweden)

    Jun Iwamoto

    2008-10-01

    Full Text Available Jun Iwamoto1, Yoshihiro Sato2, Tsuyoshi Takeda1, Hideo Matsumoto21Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Neurology, Mitate Hospital, Fukuoka, JapanAbstract: Osteoporosis most commonly affects postmenopausal women, placing them at a significant risk of fractures. In particular, hip fractures are an important cause of mortality and morbidity among postmenopausal women. Anti-resorptive therapies that produce greater decreases in bone turnover markers together with greater increases in bone mineral density (BMD are associated with greater reductions in fracture risk, especially at sites primarily composed of cortical bone such as the hip. Thus, treatment with potent anti-resorptive drugs like alendronate is a strategy for preventing hip fractures in postmenopausal women with osteoporosis. The purpose of this paper is to discuss the efficacy of alendronate against hip fractures and the mechanism for this anti-fracture efficacy in postmenopausal women with osteoporosis. A meta-analysis of randomized controlled trials has shown that alendronate reduces the risk of hip fractures by 55% in postmenopausal women with osteoporosis. According to the analyses of the Fracture Intervention Trial, each 1 standard deviation reduction in a 1-year change in bone-specific alkaline phosphatase (BSAP is associated with 39% fewer hip fractures in alendronate-treated postmenopausal women, and those with at least 30% reduction in BSAP have a 74% lower risk of hip fractures relative to those with less than 30%. Alendronate is effective in reducing the risk of hip fractures across a spectrum of ages. The mechanism for this anti-fracture efficacy has been clarified; alendronate strongly suppresses bone turnover and subsequently increases hip BMD, decreases cortical porosity, improves parameters of hip structure geometry (cortical thickness, cross-sectional area, section modulus, and buckling ratio, and produces more

  3. The Transformation of Metaphysics in Late Antiquity

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    O'Meara, Dominic

    2009-06-01

    Full Text Available The paper discusses the development of metaphysics understood as a philosophical discipline or science. I would like to propose that the last period of Greek philosophy, that going from about the 3rd to the 6th centuries A.D., made new and interesting contributions to metaphysics as a philosophical discipline, indeed made metaphysics into a metaphysical science, while also bringing out the limits of such a science. The paper has four parts. In part I, I introduce the way in which the great Aristotelian commentator of the early 3rd century, Alexander of Aphrodisias, in interpreting Aristotle's metaphysical treatise, sought to find in it a metaphysical science. In part II of the paper, I attempt to show how the Neoplatonist philosopher of the early 5th century Syrianus, not only adopted Alexander's reading of Aristotle, but was also inspired by it in finding this same metaphysical science already in Plato. In part III of the paper, I will show how all of this resulted in a masterpiece of metaphysics, the Elements of Theology written by Syrianus' pupil Proclus. Finally, in part IV, I would like to refer to what is perhaps the last great metaphysical work of Greek philosophy, the Treatise on First Principles written by Damascius, a work in which the limits of metaphysical science are explored with extraordinary subtlety and insistence. In adapting Alexander's formalization of Aristotelian metaphysical science to Platonism, Syrianus knew that such a science was a means towards, not the equivalent of, knowledge of the transcendent. Proclus knew it too, even if his Elements of Theology, in presenting metaphysical science with such systematic beauty, could give the impression of being a definitive statement. And, lest we have any illusions about the adequacy of our metaphysical science, Damascius could cure us of these, opening our minds to what lay behind, or above, our own metaphysical efforts.

  4. Musical Ontology: Critical, not Metaphysical

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    Jonathan A. Neufeld

    2014-01-01

    Full Text Available The ontology of musical works often sets the boundaries within which evaluation of musical works and performances takes place. Questions of ontology are therefore often taken to be prior to and apart from the evaluative questions considered by either performers as they present works to audiences or an audience’s critical reflection on a performance. In this paper I argue that, while the ontology of musical works may well set the boundaries of legitimate evaluation, ontological questions should not be considered as prior to or apart from critical evaluation. Rather, ontological claims are a type of critical evaluation made within musical practices. I argue that philosophers of music might learn from the debate in political philosophy about the difficulty of setting the limits of public reason in a way that remains open to a plurality of legitimate evaluative perspectives. Just as pre-political or metaphysical identification of the boundaries of public reason fail to accommodate the fact of pluralism in contemporary democratic politics, so too does a metaphysical identification of the boundaries of legitimate evaluation of musical works and performances fail to accommodate the fact of pluralism in contemporary musical practices. I apply John Rawls’s formulation of political liberalism, arguing that musical ontology should be critical, not metaphysical.

  5. Transhumanism, metaphysics, and the posthuman god.

    Science.gov (United States)

    Bishop, Jeffrey P

    2010-12-01

    After describing Heidegger's critique of metaphysics as ontotheology, I unpack the metaphysical assumptions of several transhumanist philosophers. I claim that they deploy an ontology of power and that they also deploy a kind of theology, as Heidegger meant it. I also describe the way in which this metaphysics begets its own politics and ethics. In order to transcend the human condition, they must transgress the human.

  6. Alendronate increases BMD at appendicular and axial skeletons in patients with established osteoporosis

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    Au Szeki

    2007-05-01

    Full Text Available Abstract Background To identify high-risk patients and provide pharmacological treatment is one of the effective approaches in prevention of osteoporotic fractures. This study investigated the effect of 12-month Alendronate treatment on bone mineral density (BMD and bone turnover biochemical markers in postmenopausal women with one or more non-traumatic fractures, i.e. patients with established osteoporosis. Methods A total of 118 Hong Kong postmenopausal Chinese women aged 50 to 75 with low-energy fracture at distal radius (Colles' fracture were recruited for BMD measurement at lumbar spine and non-dominant hip using Dual-Energy X-ray Absorptiometry (DXA. 47 women with BMD T-score below -2 SD at either side were identified as patients with established osteoporosis and then randomized into Alendronate group (n = 22 and placebo control group (n = 25 for BMD measurement at spine and hip using DXA and distal radius of the non-fracture side by peripheral quantitative computed tomography (pQCT, and bone turnover markers, including bone forming alkaline phosphatase (BALP and bone resorbing urinary Deoxypyridinoline (DPD. All measurements were repeated at 6 and 12 months. Results Alendronate treatment significantly increased BMD, more in weight-bearing skeletons (5.1% at spine and 2.5% at hip than in non-weight bearing skeleton (0.9% at distal radius after 12 months treatment. Spine T-score was significant improved in Alendronate group (p Conclusion 12 months Alendronate treatment was effective to increase BMD at both axial and appendicular skeletons in postmenopausal women with established osteoporosis.

  7. The Subversion of Metaphysical Detective Story

    Institute of Scientific and Technical Information of China (English)

    马雪晴

    2015-01-01

    Featured unexpected ending,unique approaches, subversion of the rules of traditional detective story,and unique themes,metaphysical detective story is quite different from these traditional ones.These character were clearly showed in Death and Compass.In this article,metaphysical features of the story are analyzed and the theme was discussed.

  8. Geographical, Sociological and Metaphysical Borders

    Directory of Open Access Journals (Sweden)

    Jacinto Choza Armenta

    2008-09-01

    Full Text Available During the different ages of history and prehistory, borders have possessed different kinds of natures. Sometimes they did not exist, at other times they have been very diffuse, while at others they have been impassable. There were no borders in the Paleolithic age, or during Greece’s Heroic Age. It was not until the creation of the city-states and the empires that borders began to be consolidated. Territorial demarcations were not very strict during the Middle Ages, either. It was in the modern age that borders acquired an impassable nature, following the birth of the modern State, and they began to weaken with the crisis of the modern State that began in the 20th century. Thus, the author claims, the construction of borders is not a fundamentally political-administrative event. Instead, it seems to be primarily a phenomenon of a cultural nature and, more specifically, of a metaphysical nature.

  9. The Value Question in Metaphysics.

    Science.gov (United States)

    Kahane, Guy

    2012-07-01

    Much seems to be at stake in metaphysical questions about, for example, God, free will or morality. One thing that could be at stake is the value of the universe we inhabit-how good or bad it is. We can think of competing philosophical positions as describing possibilities, ways the world might turn out to be, and to which value can be assigned. When, for example, people hope that God exists, or fear that we do not possess free will, they express attitudes towards these possibilities, attitudes that presuppose answers to questions about their comparative value. My aim in this paper is to distinguish these evaluative questions from related questions with which they can be confused, to identify structural constraints on their proper pursuit, and to address objections to their very coherence. Answers to such evaluative questions offer one measure of the importance of philosophical disputes.

  10. On the metaphysics of experimental physics

    CERN Document Server

    Rogers, Karl

    2005-01-01

    This provocative and critical work addresses the question of why scientific realists and positivists consider experimental physics to be a natural and empirical science. Taking insights from contemporary science studies, continental philosophy, and the history of physics, this book describes and analyses the metaphysical presuppositions that underwrite the technological use of experimental apparatus and instruments to explore, model, and understand nature. By revealing this metaphysical foundation, the author questions whether experimental physics is a natural and empirical science at all.

  11. Treatment of osteoporosis after alendronate or risedronate

    DEFF Research Database (Denmark)

    Eiken, P; Vestergaard, P

    2016-01-01

    markers. Results from 11 studies that prospectively assessed treatment after ALN or RIS in women with postmenopausal osteoporosis were reviewed. All studies are of short duration (all 24 months or less) and assess the topic of transitioning therapy from ALN or RIS. None of the studies had the statistical...... for select patients but needs to be followed up with anti-resorptive treatment to prevent a loss of the bone gained. There are only few studies-of short duration-that assess the topic of transitioning therapy from ALN or RIS, although this is a very frequent occurrence in clinical practice......Alendronate (ALN) and risedronate (RIS) are ideal as first-choice therapy options in the treatment of postmenopausal osteoporosis. What to do for patients who do not respond adequately to bisphosphonates has not been conclusively determined, but transitioning to other therapies should be considered...

  12. Metaphyseal bone loss in revision knee arthroplasty.

    Science.gov (United States)

    Ponzio, Danielle Y; Austin, Matthew S

    2015-12-01

    The etiology of bone loss encountered during revision total knee arthroplasty (TKA) is often multifactorial and can include stress shielding, osteolysis, osteonecrosis, infection, mechanical loss due to a grossly loose implant, and iatrogenic loss at the time of implant resection. Selection of the reconstructive technique(s) to manage bone deficiency is determined by the location and magnitude of bone loss, ligament integrity, surgeon experience, and patient factors including the potential for additional revision, functional demand, and comorbidities. Smaller, contained defects are reliably managed with bone graft, cement augmented with screw fixation, or modular augments. Large metaphyseal defects require more extensive reconstruction such as impaction bone grafting with or without mesh augmentation, prosthetic augmentation, use of bulk structural allografts, or use of metaphyseal cones or sleeves. While each technique has advantages and disadvantages, the most optimal method for reconstruction of large metaphyseal bone defects during revision TKA is not clearly established. PMID:26362647

  13. Metaphysics after Metaphysics: The Limitative Conception of First Philosophy in Kant

    Directory of Open Access Journals (Sweden)

    Günter Zöller

    2003-12-01

    Full Text Available The essay examines Kant’s Enlightenment conception of metaphysics as a science (Wissenschaft to be kept free of ideological prejudice and extrarational cognitive resources and to be established under the conditions of public, intersubjectively valid discourse. I analyze Kant’s self-interpretation of his transcendental philosophy as “metaphysics of metaphysics” and argue for the extensional partial identity of the critique of metaphysics and the metaphysics so rendered possible. In particular, I identify the “future metaphysics” envisioned by Kant as the “metaphysics of nature in general” or the “physiology of pure reason,” which was projected by Kant but never carried out by himself and is not to be confused with the “metaphysics of material nature” presented by Kant in his Metaphysical Principles of Natural Science (1786. I further show how in Kant the “restriction” (Beschränkung of the understanding and its pure concepts (categories to sensible intuition is counterbalanced by the “bounding” (Begrenzung of sensibility and its formal conditions (space and time to the appearances, at the exclusion of the “empty space” of the non-sensory. In drawing on Kant’s distinction between “limit” (Schranke and “boundary” (Grenze, I establish the precise position of critical metaphysics “on the boundary” of the world of sense and the world of the understanding. In concluding, I argue that for Kant a “future metaphysics that will be possible as science” is restricted to transcendental philosophy, at the exclusion of the theoretical cognition of the supersensible, which is thereby delegated forever to the object domain of practically based rational but non-scientific belief or faith (Vernunftglaube.

  14. Glucocorticoid Steroid and Alendronate Treatment Alleviates Dystrophic Phenotype with Enhanced Functional Glycosylation of α-Dystroglycan in Mouse Model of Limb-Girdle Muscular Dystrophy with FKRPP448L Mutation.

    Science.gov (United States)

    Wu, Bo; Shah, Sapana N; Lu, Peijuan; Richardson, Stephanie M; Bollinger, Lauren E; Blaeser, Anthony; Madden, Kyle L; Sun, Yubo; Luckie, Taylor M; Cox, Michael D; Sparks, Susan; Harper, Amy D; Lu, Qi Long

    2016-06-01

    Fukutin-related protein-muscular dystrophy is characterized by defects in glycosylation of α-dystroglycan with variable clinical phenotypes, most commonly as limb-girdle muscular dystrophy 2I. There is no effective therapy available. Glucocorticoid steroids have become the standard treatment for Duchenne and other muscular dystrophies with serious adverse effects, including excessive weight gain, immune suppression, and bone loss. Bisphosphonates have been used to treat Duchenne muscular dystrophy for prevention of osteoporosis. Herein, we evaluated prednisolone and alendronate for their therapeutic potential in the FKRPP448L-mutant mouse representing moderate limb-girdle muscular dystrophy 2I. Mice were treated with prednisolone, alendronate, and both in combination for up to 6 months. Prednisolone improved muscle pathology with significant reduction in muscle degeneration, but had no effect on serum creatine kinase levels and muscle strength. Alendronate treatment did not ameliorate muscle degeneration, but demonstrated a limited enhancement on muscle function test. Combined treatment of prednisolone and alendronate provided best improvement in muscle pathology with normalized fiber size distribution and significantly reduced serum creatine kinase levels, but had limited effect on muscle force generation. The use of alendronate significantly mitigated the bone loss. Prednisolone alone and in combination with alendronate enhance functionally glycosylated α-dystroglycan. These results, for the first time, demonstrate the efficacy and feasibility of this alliance treatment of the two drugs for fukutin-related protein-muscular dystrophy. PMID:27109613

  15. Alendronate functionalized mesoporous hydroxyapatite nanoparticles for drug delivery

    Energy Technology Data Exchange (ETDEWEB)

    Li, Dongdong, E-mail: lidongchem@sina.cn [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China); Zhu, Yuntao; Liang, Zhiqiang [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China)

    2013-06-01

    Highlights: ► The synthesized mesoporous hydroxyapatite has nanostructure and bioactivity. ► The materials have high surface area and amino group. ► The materials show higher drug loading and slower release rate than pure HAP. - Abstract: Mesoporous nanosized hydroxyapatite (HAP) functionalized by alendronate (ALN) was synthesized using cationic surfactant CTAB as template. The structural, morphological and textural properties were fully characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and N{sub 2} adsorption/desorption. Then the obtained materials were performed as drug delivery carriers using ibuprofen (IBU) as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). The materials showed relatively slower release rate compared with HAP due to the ionic interaction between -NH{sub 3}{sup +} on the matrix and -COO{sup −}belongs to IBU. The system provides a new concept for improving the drug loading or slowing down the release rate.

  16. Stylistics and the Metaphysics of Poetry

    Science.gov (United States)

    Anderson, Neil

    2007-01-01

    In order to better understand the worth of aesthetic experience in encountering poetry, fresh perspectives are helpful. This paper introduces the reader to modern stylistics: that is linguistic examinations of "the speaker's meaning" in literature and notes such "scientific" approaches to poetry do find common metaphysical ground with leading…

  17. Metaphysical Beliefs as Predictors of Death Anxiety.

    Science.gov (United States)

    Naidu, R. K.; Sinha, Ambalika

    1992-01-01

    Investigated impact of four metaphysical beliefs (existence of God, attributes of God, afterlife, consequences of suffering) on death anxiety. Householders (n=120), one-half of whom lived in high exposure to death sight areas, responded to pictures depicting death and nondeath scenes to measure death anxiety. Subjects from low exposure areas…

  18. A fatal case of pure metaphyseal chondroblastoma.

    Science.gov (United States)

    Binesh, Fariba; Moghadam, Reza Nafisi; Abrisham, Jalil

    2013-08-23

    The chondroblastoma (CB) is a rare cartilaginous tumour; it represents less than 1% of all bone tumours. It is mostly localised at the level of the epiphysis of long bones. We report a fatal case of pure metaphyseal CB of the tibia in a 9-year-old boy whose pulmonary metastases developed soon after operative therapy of the primary tumour.

  19. ESWT and alendronate sodium demonstrate equal protective effects in osteoarthritis of the knee

    Science.gov (United States)

    Wang, Ching-Jen; Chou, Wen-Yi; Hsu, Shan-Ling; Huang, Chien-Yiu; Cheng, Jai-Hong

    2016-01-01

    This study compared the effects of extracorporeal shock wave therapy (ESWT) and alendronate sodium (alendronate) in osteoarthritis (OA) of rat knees. The control group was subjected to a sham surgery and did not receive either ESWT or alendronate treatment. The OA group underwent anterior cruciate ligament transection (ACLT) and medial meniscectomy (MM) surgery and did not receive either ESWT or alendronate. The ESWT group underwent ACLT and MM surgery and received ESWT after the surgery. The alendronate group received alendronate after ACLT and MM surgery. The evaluations included radiograph, bone mineral density (BMD), serum C-telopeptide collagen II (CTX-II), cartilage oligomeric protein (COMP), alkaline phosphatase and osteocalcin, histopathological examination and immunohistochemical analysis. Radiographs at 12 weeks showed pronounced OA changes in the OA group. The BMD values, CTX-II, COMP, alkaline phosphatase and osteocalcin showed no significant difference between ESWT and alendronate groups. In histopathology, the Mankin and Safranin O scores significantly increased in the OA, ESWT and alendronate groups, but without any significant difference between the ESWT and alendronate groups. In immunohistochemical analysis, the von Willebrand factor (vWF), vascular endothelial factor (VEGF), soluble vascular cell adhesion molecule (sVCAM), proliferating cell nuclear antigen (PCNA), bone morphogenetic protein 2 (BMP-2), and osteocalcin expressions in articular cartilage and subchondral bone showed a significant decrease in the OA group, but no difference was noted between the ESWT and alendronate groups. In conclusion, ESWT and alendronate sodium demonstrate equal protective effects from developing osteoarthritis of the knee in rats.

  20. Ayer’s critique of metaphysics: Metaphysics as dead end of philosophy

    OpenAIRE

    İlyas Altuner

    2011-01-01

    Metaphysics, which is mentioned as the highest science by Aristotle, has lost its property of the queen of sciences more and more, afterwards it has been denied wherefore philosophy had been reduced to language analysis by philosophers in the Vienna Circle. Ayer has rejected metaphysics and he has argued that it had to be eliminated from philosophy because it was not be able to adapt to verifiability principle. Ayer’s purpose of verifiability is that to be proved something by experiment...

  1. Biocompatibility of alendronate-loaded acrylic cement for vertebroplasty

    Directory of Open Access Journals (Sweden)

    T Calvo-Fernández

    2010-10-01

    Full Text Available This paper reports a biological evaluation of a non-resorbable acrylic cement loaded with alendronate for the treatment of osteoporotic vertebral compression fractures. The cement formulation was based on polymethyl methacrylate and acrylic monomers; one of these had covalently linked vitamin E residues. The same cement in the absence of alendronate was used as a control. The setting of the charged cement presented a maximum polymerization temperature of 44ºC, a setting time of 24 min, a residual monomer content lower than 3 wt.%, a compressive strength of 99±10 MPa and an elastic modulus of 1.2±0.2 GPa. Cytotoxicity studies using human osteoblast cultures revealed that the leachable substances of the alendronate loaded cement collected between 1 and 7 days decreased cell viability to values lower than 80%. However, morphological changes and cellular damage in cells produced by the extracts decreased with the leak time. Cell adhesion and growth on charged cement was significantly lower than on the control. Implantation of the cement paste in the intra-femoral cavity of rabbits showed that initially the osteogenic activity was evident for the cement charged with alendronate, and the osteosynthesis process took place mainly in the trabeculae and was manifested by the presence of a non-mineralised osseous spicule. The interface between material and adjacent bone tissue was initially characterized by a variable fibrous response that in many cases it appeared reduced to thin connective tissue after a 24-week-period.

  2. A comparative study of the effects of daily minodronate and weekly alendronate on upper gastrointestinal symptoms, bone resorption, and back pain in postmenopausal osteoporosis patients.

    Science.gov (United States)

    Yoshioka, Toru; Okimoto, Nobukazu; Okamoto, Ken; Sakai, Akinori

    2013-03-01

    The purpose of the present study was to precisely compare both the efficacy and abdominal symptom-related quality of life after treatment with daily minodronate and weekly alendronate in patients with primary postmenopausal osteoporosis. The efficacy of the two drugs was assessed based on improvements in a bone turnover marker, back pain, and gastrointestinal symptoms that impair quality of life, which was assessed using the Izumo scale questionnaire. In the minodronate group, there were no significant changes during the treatment period in the specific scores for heartburn, epigastralgia and epigastric fullness, whereas all of the scores were significantly elevated at some time point after drug administration in the alendronate group. Urinary N-telopeptide of type I collagen (uNTX), a bone resorption marker, and bone-specific alkaline phosphatase, a bone formation marker, significantly decreased in both groups, but decreases in uNTX in the minodronate group was observed significantly earlier compared with those in the alendronate group. The back pain scores, which were obtained using a visual analog scale, were significantly reduced in both groups. However, analgesic effects were detected earlier in the minodronate group. In conclusion, compared with weekly alendronate, daily minodronate improved bone turnover and back pain more promptly without causing upper gastrointestinal symptoms.

  3. Ayer’s critique of metaphysics: Metaphysics as dead end of philosophy

    Directory of Open Access Journals (Sweden)

    İlyas Altuner

    2011-08-01

    Full Text Available Metaphysics, which is mentioned as the highest science by Aristotle, has lost its property of the queen of sciences more and more, afterwards it has been denied wherefore philosophy had been reduced to language analysis by philosophers in the Vienna Circle. Ayer has rejected metaphysics and he has argued that it had to be eliminated from philosophy because it was not be able to adapt to verifiability principle. Ayer’s purpose of verifiability is that to be proved something by experiment and observation. This, with Wittgensteinian statement, is to say drawing the picture of meaning or fact

  4. Alveolar bone dynamics in osteoporotic rats treated with raloxifene or alendronate: confocal microscopy analysis

    Science.gov (United States)

    Ramalho-Ferreira, Gabriel; Faverani, Leonardo Perez; Grossi-Oliveira, Gustavo Augusto; Okamoto, Tetuo; Okamoto, Roberta

    2015-03-01

    In this study, the characteristics of the alveolar bone of rats with induced osteoporosis were examined. Thirty-two rats were divided into four groups according to the induction of osteoporosis and drugs administered: OG, osteoporotic rats without treatment (negative control); SG, rats which underwent sham surgery ovariectomy (SHAM); alendronate (AG), osteoporotic rats treated with alendronate; and RG, osteoporotic rats treated with raloxifene (RG). On the 8th day after ovariectomy and SHAM surgeries, drug therapy was started with AG or RG. On the 52nd day, 20 mg/kg calcein was administered to all of the rats, and on the 80th day, 20 mg/kg alizarin red was administered. Euthanasia was performed on the 98th day. The bone area marked by fluorochromes was calculated and data were subjected to two-way ANOVA test and Tukey's post-hoc test (pbone turnover only between RG and SG (p=0.074) and AG and OG (p=0.138). All other comparisons showed significant differences (pbone turnover was observed in RG and SG groups. RG was the medication that improved the dynamics of the alveolar bone of rats with induced osteoporosis, resembling that of healthy rats.

  5. Kantowska metafizyka percepcji (Kant’s Metaphysics of Perception

    Directory of Open Access Journals (Sweden)

    Paweł Sikora

    2009-06-01

    Full Text Available This article treats of an issue of Kant’s the metaphysics of perception as a specific sphere where concept of sense perception within transcendental philosophy seem to be rooted into a wider context of metaphysical presuppositions. The text is an epitome of a few Kant’s aporias which appear when he does not notice a metaphysical background which constitutes basic relation between subject and object in sense perception.

  6. M. Heidegger: Metaphysical character of technical scientific civilisation

    OpenAIRE

    Savić Mićo

    2009-01-01

    In this paper, author deals with Heidegger's account of the modern age as the epoch based on Western metaphysics. In the first part of the paper, he shows that, according to Heidegger, modern interpretation of the reality as the world picture, is essentially determined by Descartes' philosophy. Then, author exposes Heidegger's interpretation of the turn which already took place in Plato's metaphysics and which made possible Descartes' metaphysics and modern epoch. In the second part of the pa...

  7. Alendronate and estrogen-progestin in the long-term prevention of bone loss

    DEFF Research Database (Denmark)

    Ravn, Pernille; Bidstrup, M; Wasnich, R D;

    1999-01-01

    alendronate to placebo than in those who continuously received placebo. In years 3 and 4, bone loss in participants who switched from alendronate to placebo was similar to that seen during years 1 and 2 in those who continuously received placebo. Compared with 5 mg of alendronate per day, estrogen-medroxyprogesterone...... acetate produced similar increases in bone mineral density and estradiol-norethisterone acetate produced increases that were substantially greater. CONCLUSIONS: Four years of treatment with alendronate or estrogen-progestin prevented postmenopausal bone loss. A residual effect was seen 2 years after...

  8. Esophageal and gastric cancer incidence and mortality in alendronate users

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Pazianas, Michael; Eiken, Pia Agnete;

    2012-01-01

    their esophageal or gastric location could be accurately distinguished. We conducted a register-based, open cohort study using national healthcare data for Denmark. Upper endoscopy frequency, cancer incidence and mortality was examined in 30,606 alendronate users (female, age 50¿+¿) and 122,424 matched controls......Recent studies have reached conflicting conclusions regarding the risk of esophageal cancer with oral bisphosphonates. Prior studies did not record the number of cancer deaths or endoscopy rates, which could be higher in bisphosphonate users and lead to more cancers being diagnosed at a stage when....... Primary outcomes were esophageal cancer incidence and death due to esophageal cancer. The analysis showed that alendronate users were more likely to have undergone recent upper endoscopy (4.1 vs 1.7%, p¿...

  9. Proton Pump Inhibitor Use and the Antifracture Efficacy of Alendronate

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Eiken, Pia Agnete; Eastell, Richard

    2011-01-01

    Background: Proton pump inhibitors (PPIs) are widely used in elderly patients and are frequently coadministered in users of oral bisphosphonates. Biologically, PPIs could affect the absorption of calcium, vitamin B12, and bisphosphonates and could affect the osteoclast proton pump, thus interacting...... no significant impact of concurrent use of histamine H2 receptor blockers. Conclusions: Concurrent PPI use was associated with a dose-dependent loss of protection against hip fracture with alendronate in elderly patients. This is an observational study, so a formal proof of causality cannot be made...... with bisphosphonate antifracture efficacy. Moreover, PPIs themselves have been linked to osteoporotic fractures. Methods: Population-based, national register–based, open cohort study of 38 088 new alendronate sodium users with a mean duration of follow-up of 3.5 years. We related risk of hip fracture...

  10. Mendelssohn and Kant on Mathematics and Metaphysics

    OpenAIRE

    Callanan, John Joseph

    2014-01-01

    The difference between the method of metaphysics and the method of mathematics was an issue of central concern for Kant in both the Pre-Critical and Critical periods. I will argue that when Kant speaks of the ‘philosophical method’ in the Doctrine of Method in the Critique of Pure Reason (CPR), he frequently has in mind not his own methodology but rather the method of conceptual analysis associated with rationalism. The particular target is Moses Mendelssohn’s picture of analysis contained in...

  11. On John Donne g Metaphysical Poetry--Seen from Song

    Institute of Scientific and Technical Information of China (English)

    Zhang Yun

    2012-01-01

    John Donne is one of the most learned and witty? poet in seventeenth century. He created? a great deal of? metaphysical poetry during his whole life, in which Song is the very popular with? readers- In this paper, we study the features of John Donne's metaphysical poetry by analyzing? this poem.

  12. Observability, Visualizability and the Question of Metaphysical Neutrality

    Science.gov (United States)

    Wolff, Johanna

    2015-09-01

    Theories in fundamental physics are unlikely to be ontologically neutral, yet they may nonetheless fail to offer decisive empirical support for or against particular metaphysical positions. I illustrate this point by close examination of a particular objection raised by Wolfgang Pauli against Hermann Weyl. The exchange reveals that both parties to the dispute appeal to broader epistemological principles to defend their preferred metaphysical starting points. I suggest that this should make us hesitant to assume that in deriving metaphysical conclusions from physical theories we place our metaphysical theories on a purely empirical foundation. The metaphysics within a particular physical theory may well be the result of a priori assumptions in the background, not particular empirical findings.

  13. Audism: exploring the metaphysics of oppression.

    Science.gov (United States)

    Bauman, H-Dirksen L

    2004-01-01

    This article traces the development of the concept of "audism" from its inception in the mid-1970s by exploring three distinct dimensions of oppression: individual, institutional, and metaphysical. Although the first two aspects of audism have been identified, there is a deeply rooted belief system regarding language and human identity that is yet to be explored within the context of audism. This article attempts to expose how our particular historical and philosophical constructions of language and being have created what French philosopher Jacques Derrida calls phonocentrism. Although Derrida does not discuss audism, his deconstruction of the Western notion of language provides a lens through which we can better see the orientation that has provided fertile ground out of which individual and institutional audism has flourished. PMID:15304445

  14. The Metaphysics of Chinese Information Philosophy

    DEFF Research Database (Denmark)

    Liqian, Zhou; Brier, Søren

    2015-01-01

    Compared with other transdisciplinary frames of information Wu Kun’s philosophy of information differs in its metaphysical framework in that it has a background in a conception of Dialectics of Nature coming from the old Stalin textbook system but also a part of the renewal of thinking in China...... appearing through the thought liberty movement in the 1980s, which among other things also added a modern view of information to Chinese thinking. Still it is a philosophy in a distinctive Chinese style. Wu’s philosophical system begins by re-dividing the field of existence and founding a new ontological...... area or aspect of being, which he called the world of information and named it objective unreality. This, ontological framework, different from that in the West, made the concept of information in his system different from the information concept in Shannon’s and even Wiener’s sense. Wu’s philosophy...

  15. Metaphysics of the Principle of Least Action

    CERN Document Server

    Terekhovich, Vladislav

    2015-01-01

    Despite the importance of the variational principles of physics, there have been relatively few attempts to consider them for a realistic framework. In addition to the old teleological question, this paper continues the recent discussion regarding the modal involvement of the principle of least action and its relations with the Humean view of the laws of nature. The reality of the possible paths in the principle of least action is examined from the perspectives of the contemporary metaphysics of modality and Leibniz's concept of the possibles striving from essence to existence. This paper introduces a model of a two-level modality based on an intuition that deep ontological connections exist between the possible paths in the principle of least action and possible quantum histories in the Feynman path integral. The proposed modal interpretation of the principle of least action replaces the classical representation of the system's motion along a single history in the actual modality by the simultaneous motions ...

  16. Alendronate prevents postmenopausal bone loss in women without osteoporosis. A double-blind, randomized, controlled trial. Alendronate Osteoporosis Prevention Study Group

    DEFF Research Database (Denmark)

    McClung, M; Clemmesen, B; Daifotis, A;

    1998-01-01

    to one of five regimens: oral placebo; oral alendronate, 1, 5, or 10 mg/d; or oral alendronate, 20 mg/d for 2 years followed by placebo during the third year (20/0 mg/d). MEASUREMENTS: Bone mineral density was measured by dual-energy x-ray absorptiometry. Bone turnover and bone quality were assessed...... with biochemical markers and bone histomorphometry. RESULTS: Alendronate at 5, 10, and 20/0 mg/d increased bone mineral density from baseline at the lumbar spine, femoral neck, and trochanter by 1% to 4% and in the total body by 0.3% to 1.0%; placebo led to losses of 2% to 4% at these sites....... Alendronate, 1 mg/d, attenuated losses relative to those seen with placebo. Alendronate decreased markers of bone resorption to a new steady state by 3 months and decreased markers of bone formation by 6 to 12 months. Bone quality remained normal. At all dosages studied, alendronate had a safety and...

  17. Preparation and biological studies of 68Ga-DOTA-alendronate

    OpenAIRE

    Ashraf Fakhari; Amir Jalilian; Fariba Johari-daha; Mehdi Shafiee-Ardestani; Ali Khalaj

    2016-01-01

    Objective(s): In line with previous research on the development of conjugated bisphosphonate ligands as new bone-avid agents, in this study, DOTA conjugated alendronate (DOTA-ALN) was synthesized and evaluated after labeling with gallium-68 (68Ga).Methods: DOTA-ALN was synthesized and characterized, followed by 68Ga-DOTA-ALN preparation, using DOTA-ALN and 68GaCl3 (pH: 4-5) at 92-95°C for 10 min. Stability tests, hydroxyapatite assay, partition coefficient calculation,biodistribution studies,...

  18. Benefit period using alendronate to increase bone mineral density in women with osteoporosis?

    Institute of Scientific and Technical Information of China (English)

    Ferda Ozdemir; Meliha Rodoplu

    2005-01-01

    Background Alendronate, a nitrogen-containing bisphosphonate is a specific inhibitor of bone resorption and now in the forefront of treatment of osteoporosis. In this study, we reported a significant increase in bone mineral density (BMD) of the spine and the hip in postmenopausal women taking alendronate at 10 mg/d for 1, 2 and 3 years. Methods Participants had received daily, oral, 10 mg dose of alendronate for one to three years and placed into one of three groups according to alendronate treatment duration: 41 women received alendronate for 1 year (group Ⅰ), 46 received alendronate for 2 years (group Ⅱ), and 30 received alendronate for 3 years (group Ⅲ). Measurements of bone density had been made by dual energy X-ray absorbtiometry once each year. Results The differences in L2-L4, L2, L4, femoral neck and trochanter BMD values before and after treatment for first group were significantly different. In second group, significant differences between initial and after treatment were found at the other sites except at the Ward's triangle. In the third group, only a significant increase in the L2-L4, L2, L3, L4, trochanter BMD values between before treatment and at the end of third year was found. Comparisons between groups were performed with Student's t test. ANOVA was used to test the age, menopause age, menopause duration and initial BMD values between the three groups. Calculated P values of less than 0.05 were considered statistically significant. Conclusions Alendronate had increased BMD significantly at the spine and hip in postmenopausal women over three years. Increases of BMD in third group were significant during the first and second years. However, continued therapy with alendronate had been required to maintain the gain in BMD over the third year.

  19. The abundant world: Paul Feyerabend's metaphysics of science.

    Science.gov (United States)

    Brown, Matthew J

    2016-06-01

    The goal of this paper is to provide an interpretation of Feyerabend's metaphysics of science as found in late works like Conquest of Abundance and Tyranny of Science. Feyerabend's late metaphysics consists of an attempt to criticize and provide a systematic alternative to traditional scientific realism, a package of views he sometimes referred to as "scientific materialism." Scientific materialism is objectionable not only on metaphysical grounds, nor because it provides a poor ground for understanding science, but because it implies problematic claims about the epistemic and cultural authority of science, claims incompatible with situating science properly in democratic societies. I show how Feyerabend's metaphysical view, which I call "the abundant world" or "abundant realism," constitute a sophisticated and challenging form of ontological pluralism that makes interesting connections with contemporary philosophy of science and issues of the political and policy role of science in a democratic society. PMID:27269274

  20. Newton's Metaphysics of Space as God's Emanative Effect

    Science.gov (United States)

    Jacquette, Dale

    2014-09-01

    In several of his writings, Isaac Newton proposed that physical space is God's "emanative effect" or "sensorium," revealing something interesting about the metaphysics underlying his mathematical physics. Newton's conjectures depart from Plato and Aristotle's metaphysics of space and from classical and Cambridge Neoplatonism. Present-day philosophical concepts of supervenience clarify Newton's ideas about space and offer a portrait of Newton not only as a mathematical physicist but an independent-minded rationalist philosopher.

  1. Classic metaphyseal lesion following external cephalic version and cesarean section.

    Science.gov (United States)

    Lysack, John T; Soboleski, Don

    2003-06-01

    We report a case of an otherwise healthy neonate diagnosed at birth with a classic metaphyseal lesion of the proximal tibia following external cephalic version for frank breech presentation and a subsequent urgent cesarean section. Although the classic metaphyseal lesion is considered highly specific for infant abuse, this case demonstrates the importance of obtaining a history of obstetric trauma for neonates presenting to the imaging department for suspected non-accidental injury. PMID:12709748

  2. Classic metaphyseal lesion following external cephalic version and cesarean section

    Energy Technology Data Exchange (ETDEWEB)

    Lysack, John T.; Soboleski, Don [Department of Diagnostic Radiology, Queen' s University, Kingston General Hospital, 76 Stuart Street, K7L 2V7, Kingston, Ont. (Canada)

    2003-06-01

    We report a case of an otherwise healthy neonate diagnosed at birth with a classic metaphyseal lesion of the proximal tibia following external cephalic version for frank breech presentation and a subsequent urgent cesarean section. Although the classic metaphyseal lesion is considered highly specific for infant abuse, this case demonstrates the importance of obtaining a history of obstetric trauma for neonates presenting to the imaging department for suspected non-accidental injury. (orig.)

  3. Murk Jansen's metaphyseal chondrodysplasia with long-term followup.

    Science.gov (United States)

    Silverthorn, K G; Houston, C S; Duncan, B P

    1987-01-01

    The fourteenth reported patient with Murk Jansen's metaphyseal chondrodysplasia is presented, with a remarkable followup from birth to the age of 15 years. Numerous invasive procedures were performed in pursuit of erroneous provisional diagnoses. Five of these patients presented in infancy with radiographic metaphyseal changes similar to rickets, but with preservation of the provisional zone of calcification. Following infancy, these patients reveal the more typical short-limbed dwarfism, with fusiform joints and bowed extremities.

  4. Metaphyseal fractures mimicking abuse during treatment for clubfoot

    Energy Technology Data Exchange (ETDEWEB)

    Grayev, A.M.; Boal, D.K.B. [Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, PA (United States); Wallach, D.M.; Segal, L.S. [Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, PA (United States)

    2001-08-01

    Background. Metaphyseal injuries resembling the classic metaphyseal lesion (CML) of abuse may occur as the result of serial casting during treatment of clubfoot deformity. Mentioned in the orthopedic literature in 1972, this iatrogenic fracture has not been described in the radiologic literature nor has the similarity to injuries occurring with abuse been previously recognized. Objective. To describe the mechanism and radiographic appearance of metaphyseal injury observed during serial casting of clubfoot. Note similarities to the CML of abuse. Materials and methods. Eight children ranging in age from 1 to 4 months underwent casting for clubfoot. Five orthopedic surgeons from three different institutions performed the casting. Two patients had spina bifida and one, arthrogryposis. A complete skeletal survey was performed on one child who was abused; there was no suspicion of abuse in the remaining seven. Results. All children manifest injury with periosteal new bone. One child had clear evidence of abuse with 24 rib fractures. X-rays of lower extremities in short leg casts revealed bilateral tibial metaphyseal fractures. Four other children had metaphyseal fractures resembling the CML of abuse, and three developed an area of sclerosis within the metaphysis. Conclusion. In the setting of serial casting for equinovarus deformity, metaphyseal injury even the CML of abuse may be noted. Since inflicted injuries are almost always unobserved and explanations rarely offered, the fact that the CML occurs as a result of orthopedic manipulation may offer some further insight concerning the pathogenesis of this well-described abuse injury. (orig.)

  5. Metaphyseal fractures mimicking abuse during treatment for clubfoot

    International Nuclear Information System (INIS)

    Background. Metaphyseal injuries resembling the classic metaphyseal lesion (CML) of abuse may occur as the result of serial casting during treatment of clubfoot deformity. Mentioned in the orthopedic literature in 1972, this iatrogenic fracture has not been described in the radiologic literature nor has the similarity to injuries occurring with abuse been previously recognized. Objective. To describe the mechanism and radiographic appearance of metaphyseal injury observed during serial casting of clubfoot. Note similarities to the CML of abuse. Materials and methods. Eight children ranging in age from 1 to 4 months underwent casting for clubfoot. Five orthopedic surgeons from three different institutions performed the casting. Two patients had spina bifida and one, arthrogryposis. A complete skeletal survey was performed on one child who was abused; there was no suspicion of abuse in the remaining seven. Results. All children manifest injury with periosteal new bone. One child had clear evidence of abuse with 24 rib fractures. X-rays of lower extremities in short leg casts revealed bilateral tibial metaphyseal fractures. Four other children had metaphyseal fractures resembling the CML of abuse, and three developed an area of sclerosis within the metaphysis. Conclusion. In the setting of serial casting for equinovarus deformity, metaphyseal injury even the CML of abuse may be noted. Since inflicted injuries are almost always unobserved and explanations rarely offered, the fact that the CML occurs as a result of orthopedic manipulation may offer some further insight concerning the pathogenesis of this well-described abuse injury. (orig.)

  6. 阿伦膦酸钠对卵巢切除大鼠骨质量的影响%Effect of alendronate on bone quality in oophorectomized rats

    Institute of Scientific and Technical Information of China (English)

    吴友伟; 史丽萍; 张健

    2013-01-01

    Objective To investigate the effect of Alendronate on bone mass and bone quality in oophorecto-mized rats. Methods 48 SD rats aged 12 months were randomly divided into OVX (ovariectomized) , SHAM (sham-operated) group, ALL (Alendronate low dosage) group, and ALH (Alendronate high dosage) group. Bilateral oopho-rectomy was performed in the ALL and ALH groups. At the same time, the two groups expriment rats were given Alendronate in the dosage of 0. 5 mg/kg/day and 1. 0 mg/kg/day for 12 months. Results The urinary calcium/creatinine ratio was significanly lower in Alendronate-treated OP model groups than that in OVX group ( P < 0. 05 ). The urinary hydroxyproline/creatinine ratio and serum alkaline phosphatase level showed a decreasing tendency in Alendronate-treated OP model groups as compared with OVX group ( P < 0. 05 ) . Dry bone weight, bone ash weight, bone calcium content in SHAM group were higher than OVX group, and those in the ALL and ALH groups were higher than OVX group (P <0. 05). The femur bone mineral density, anti-bend strength, and the body bone mineral density in ALL and ALH was increased in alendronate than that in OVX group ( P < 0. 05 ). Conclusion The oophorectomized SD rats showed clearly osteoporosis 12 months groups after operation. Alendronate can increase bone mass, improve bone quality, which is dose-dependent in a certain range of bone quality improvement.%目的 探讨阿仑膦酸钠对骨量和骨质量的作用.方法 将48只12月龄SD大鼠随机分为去卵巢模型组(OVX)、假手术组(SHAM)、低剂量阿仑膦酸钠组(ALL)、高剂量阿仑膦酸钠组(ALH),每组12只.ALL与ALH组大鼠作双侧卵巢切除,分别给予阿伦膦酸钠0.5mg/ (kg·d)与1.0 mg/kg (kg·d),持续用药12个月.结果 ALL及ALH组大鼠尿钙与肌酐比值(Ca/Cr)均低于OVX组,差异有统计学意义(P<0.05);ALL及ALH组尿羟脯氨酸与肌酐比值(HOP/Cr)与血清碱性磷酸酶水平(ALP)均较OVX组低,差异有统计学意义(P<0

  7. The metaphyseal bone defect predicts outcome in reverse shoulder arthroplasty for proximal humerus fracture sequelae.

    Science.gov (United States)

    Greiner, Stefan; Uschok, Stephan; Herrmann, Sebastian; Gwinner, Clemens; Perka, Carsten; Scheibel, Markus

    2014-06-01

    Reverse shoulder arthroplasty (RSA) represents an established procedure for treatment of fracture sequelae (FS) after proximal humerus fractures. The present work evaluates which factors are of influence for the clinical outcome. Fifty cases (mean age 69, range 44-89) have been evaluated postoperatively clinically [Constant Score (CS)] and radiographically (mean FU 34; range 24-93 months). The type of primary treatment, the amount of a metaphyseal bone defect, the preoperative status of the rotator cuff, the number of previous operative interventions and the type of FS according to Boileau were analysed whether they are of influence for clinical outcome. The mean CS increased significantly from 16.9 ± 6.7 preoperatively to 54.1 ± 15.7 points postoperatively. The CS of primary conservative treatment was significantly higher in comparison to primary operative treatment. Patients with a metaphyseal bone defect of more than 3 cm had significantly lower CS results. Degenerative changes of the teres minor muscle also had a significant negative influence on clinical results. Score results decreased with increasing number of previous operations. There were no significant difference in between patients classified as Boileau type I and II (category 1) compared to types III and IV (category 2). RSA significantly improved the clinical result. A metaphyseal bone defect and preoperative degeneration of the teres minor showed to be negative prognostic factors. Primary operative treatment and the number of previous operations also negatively influenced the clinical result.

  8. Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy

    Energy Technology Data Exchange (ETDEWEB)

    Lucisano, Marilia Pacifico; Nelson-Filho, Paulo; Silva, Raquel Assed Bezerra da; Silva, Lea Assed Bezerra da, E-mail: nelson@forp.usp.br [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Fac. de Odontologia. Dept. de Clinica Pediatrica, Preventiva e Odontologia Comunitaria; Morse, Leslie [Department of Physical Medicine and Rehabilitation, School of Medicine, Harvard Univ., Boston, MA (United States); Battaglino, Ricardo [Department of Skeletal Biology, Forsyth Institute, Cambridge, MA (United States); Watanabe, Plauto Christopher Aranha [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Fac. de Odontologia. Dept. de Morfologia, Estomacologia e Fisiologia

    2013-05-15

    Precise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dual energy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy. (author)

  9. Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy

    International Nuclear Information System (INIS)

    Precise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dual energy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy. (author)

  10. Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate.

    Science.gov (United States)

    Khan, Mohd Parvez; Singh, Atul Kumar; Singh, Abhishek Kumar; Shrivastava, Pragya; Tiwari, Mahesh Chandra; Nagar, Geet Kumar; Bora, Himangshu Kousik; Parameswaran, Venkitanarayanan; Sanyal, Sabyasachi; Bellare, Jayesh R; Chattopadhyay, Naibedya

    2016-03-01

    Cathepsin K (CK), a lysosomal cysteine protease, is highly expressed in mature osteoclasts and degrades type 1 collagen. Odanacatib (ODN) is a selective and reversible CK inhibitor that inhibits bone loss in preclinical and clinical studies. Although an antiresorptive, ODN does not suppress bone formation, which led us to hypothesize that ODN may display restorative effect on the osteopenic bones. In a curative study, skeletally mature New Zealand rabbits were ovarectomized (OVX) and after induction of bone loss were given a steady-state exposure of ODN (9 mM/d) for 14 weeks. Sham-operated and OVX rabbits treated with alendronate (ALD), 17b-estradiol (E2), or parathyroid hormone (PTH) served as various controls. Efficacy was evaluated by assessing bone mineral density (BMD), bone microarchitecture (using micro-computed tomography), fluorescent labeling of bone, and biomechanical strength. Skeletal Ca/P ratio was measured by scanning electron microscopy (SEM) with X-ray microanalysis, crystallinity by X-ray diffraction, and bone mineral density distribution (tissue mineralization) by backscattered SEM. Between the sham and ODN-treated osteopenic groups, lumbar and femur metaphyseal BMD, Ca/P ratio, trabecular microstructure and geometric indices, vertebral compressive strength, trabecular lining cells, cortical parameters (femoral area and thickness and periosteal deposition), and serum P1NP were largely comparable. Skeletal improvements in ALD-treated or E2-treated groups fell significantly short of the sham/ODN/PTH group. However, the ODN group displayed reduced ductility and enhanced brittleness of central femur, which might have been contributed by higher crytallinity and tissue mineralization. Rabbit bone marrow stromal cells expressed CK and when treated with ODN displayed increased formation of mineralized nodules and decreased apoptosis in serum-deficient medium compared with control. In vivo, ODN did not suppress remodeling but inhibited osteoclast activity

  11. The wave function essays on the metaphysics of quantum mechanics

    CERN Document Server

    Albert, David Z

    2013-01-01

    This is a new volume of original essays on the metaphysics of quantum mechanics. The essays address questions such as: What fundamental metaphysics is best motivated by quantum mechanics? What is the ontological status of the wave function? Does quantum mechanics support the existence of any other fundamental entities, e.g. particles? What is the nature of the fundamental space (or space-time manifold) of quantum mechanics? What is the relationship between the fundamental ontology of quantum mechanics and ordinary, macroscopic objects like tables, chairs, and persons? This collection includes a comprehensive introduction with a history of quantum mechanics and the debate over its metaphysical interpretation focusing especially on the main realist alternatives.

  12. A critical introduction to the metaphysics of time

    CERN Document Server

    Curtis, Benjamin

    2016-01-01

    What is the nature of time? Does it flow? Do the past and future exist? Drawing connections between historical and present-day questions, A Critical Introduction to the Metaphysics of Time provides an up-to-date guide to one of the most central and debated topics in contemporary metaphysics. Introducing the views and arguments of Parmenides, Plato, Aristotle, Descartes, Newton and Leibniz, this accessible introduction covers the history of the philosophy of time from the Pre-Socratics to the beginning of the 20th Century. The historical survey presents the necessary background to understanding more recent developments, including McTaggart's 1908 argument for the unreality of time, the open future, the perdurance/endurance debate, the possibility of time travel, and the relevance of current physics to the philosophy of time. Informed by cutting-edge philosophical research, A Critical Introduction to the Metaphysics of Time evaluates influential historical arguments in the context of contemporary developments. ...

  13. Revisiting the Applicability of Metaphysical Identity in Quantum Mechanics

    CERN Document Server

    da Costa, Newton

    2016-01-01

    We discuss the hypothesis that the debate about the interpretation of the orthodox formalism of quantum mechanics (QM) might have been misguided right from the start by a biased metaphysical interpretation of the formalism and its inner mathematical relations. In particular, we focus on the orthodox interpretation of the congruence relation, '=', which relates equivalent classes of different mathematical representations of a vector in Hilbert space, in terms of metaphysical identity. We will argue that this seemingly "common sense" interpretation, at the semantic level, has severe difficulties when considering the syntactic level of the theory.

  14. Real-Life and RCT Participants: Alendronate Users Versus FITs' Trial Eligibility Criterion.

    Science.gov (United States)

    Reyes, Carlen; Pottegård, Anton; Schwarz, Peter; Javaid, M Kassim; Van Staa, Tjeerd P; Cooper, Cyrus; Diez-Perez, Adolfo; Abrahamsen, Bo; Prieto-Alhambra, Daniel

    2016-09-01

    We aimed to characterize incident users of alendronate from Denmark and Spain, and investigate their eligibility for participation in the pivotal Fracture Intervention Trial (FIT). This is an international cross-sectional study, where the data were obtained from the SIDIAP database (Sistema d'Informació per al Desenvolupament de l'Investigació en Atenció Primària) from Catalonia (Spain) and the Danish Health Registries (DHR). This study included patients who were incident users of alendronate, ≥40 years old with no history of Paget's disease. Our measurements were the proportion of incident users of alendronate who were not eligible to participate in FIT. 14,316 and 21,221 subjects initiated alendronate in 2006-2007 (SIDIAP) and 2005-2006 (DHR), respectively. SIDIAP and DHR alendronate user cohorts had 2347 (16.4 %) and 5275 (24.9 %) subjects aged >80 years old, reported 9 (0.1 %) and 91 (0.4 %) diagnoses of myocardial infarction, 423 (3 %) and 368 (1.7 %) of erosive gastro-intestinal disease, 200 (1.4 %) and 1109 (5.2 %) of dyspepsia, and 349 (2.4 %) and 149 (0.7 %) of metabolic bone disease, all of which were exclusion criteria in FIT. Men [3818 (26.7 %) in SIDIAP and 3885 (18.3 %) in DHR] and glucocorticoid users [1229 (8.6 %) in SIDIAP and 4716 (22.2 %) in DHR] were also excluded from the FIT trial. Overall, 3447 (35.4 %) SIDIAP and 6228 (44.5 %) (when not considering men and glucocorticoid users) DHR of incident alendronate users would have been excluded from FIT. One in two real-life users of alendronate exhibited one or more clinical characteristics that would have led to them being excluded from the FIT trial. PMID:27099132

  15. Metaphysical and anthropological measurements sporting life as the basis of self-identity

    OpenAIRE

    Білогур, Влада Євгеніївна

    2014-01-01

    The article describes the theoretical concept of sport as a measure of the optimum being in the context of metaphysical and anthropological bases. Revealed the term "metaphysics" and the metaphysical foundations of sport as being the optimum expression of personality, for which there is a characteristic game character, competitiveness, education, orientation, physical activity, aimed at mapping the physical and spiritual spobnostey person. The substantiation of metaphysics in the context of t...

  16. Fall and Rise of Aristotelian Metaphysics in the Philosophy of Science

    Science.gov (United States)

    Lamont, John

    2009-01-01

    The paper examines the fortunes of Aristotelian metaphysics in science and the philosophy of science. It considers the Enlightenment claim that such a metaphysics is fundamentally unscientific, and that its abandonment was essential to the scientific revolution. The history of the scientific revolution and the metaphysical debates involved in it…

  17. The experiment in rat model with alendronate inhibiting abnormal alve olar bone resorption%Alendronate阻止牙槽骨骨吸收的实验研究

    Institute of Scientific and Technical Information of China (English)

    王晓敏; 杨宗萍; 于世凤

    2001-01-01

    Objective.Osteoporosis and periodontal disease animal models were used to evaluate the anti-resorption effect of alendr onate on bone.Methods.To establish osteoporosis and alveo lar bone resorption animal models.The experimental groups (ovariectomized dental ligature group and simple dental ligature group) were given alendronate in 0. 5mg/kg BW by subcutaneous injection after six weeks of ovariectomy and dental ligature,three times a week for 6 weeks.All the animals were sacrifised 12 weeks after the operation.The blood samples were collected for determination of bioch emical indexes.The left femora and jaw bone were processed for histomorphometry. The right femora and mendibles were prepared for determination of bone density and bone biodynamics.Results.As compared with the control groups (without alendronate),the values of experimental groups (with alendronate ) were all significantly improved on bone density and bone anti-curve power.The alkaline phosphatase,calcium in serum of ovariectomy groups (without alendronate ) were obviously increased.In the alendronate group,however,these indexes werec lose to normal levels.In histomorphometry,there were little inflammation in gingiva and less level alveolar bone resorption in the experimental groups;but there was obvious gingivitis and level alveolar bone resorption in the control groups .Conclusion.Alendronate can effectively treat osteoporosis,increase bone volume and prevent bone lose in ovariectomized female rats and inhibit pathological alveolar bone resorption.%目的 评价双膦酸盐Alendronate抑制牙槽骨骨吸收的作用。方法 建立骨质疏松及牙槽骨吸收动物模型,建模术后六周,给实验组皮下注射Alendronate每周3次,共6周;用血生化指标骨生物力学、骨密度测量、组织形态学等方法进行药效评价。结果 股骨骨密度对照 组与用药组相比明显降低(P<0.01);血清碱性磷酸酶对照组与用药组相比明显升

  18. Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage

    Science.gov (United States)

    Bikle, D. D.; Morey-Holton, E. R.; Doty, S. B.; Currier, P. A.; Tanner, S. J.; Halloran, B. P.

    1994-01-01

    Loss of bone mass during periods of skeletal unloading remains an important clinical problem. To determine the extent to which resorption contributes to the relative loss of bone during skeletal unloading of the growing rat and to explore potential means of preventing such bone loss, 0.1 mg P/kg alendronate was administered to rats before unloading of the hindquarters. Skeletal unloading markedly reduced the normal increase in tibial mass and calcium content during the 9 day period of observation, primarily by decreasing bone formation, although bone resorption was also modestly stimulated. Alendronate not only prevented the relative loss of skeletal mass during unloading but led to a dramatic increase in calcified tissue in the proximal tibia compared with the vehicle-treated unloaded or normally loaded controls. Bone formation, however, assessed both by tetracycline labeling and by [3H]proline and 45Ca incorporation, was suppressed by alendronate treatment and further decreased by skeletal unloading. Total osteoclast number increased in alendronate-treated animals, but values were similar to those in controls when corrected for the increased bone area. However, the osteoclasts had poorly developed brush borders and appeared not to engage the bone surface when examined at the ultrastructural level. We conclude that alendronate prevents the relative loss of mineralized tissue in growing rats subjected to skeletal unloading, but it does so primarily by inhibiting the resorption of the primary and secondary spongiosa, leading to altered bone modeling in the metaphysis.

  19. A fast and simple spectrofluorometric method for the determination of alendronate sodium in pharmaceuticals

    Directory of Open Access Journals (Sweden)

    Jafar Ezzati Nazhad Dolatabadi

    2014-03-01

    Full Text Available Introduction: Alendronate sodium enhances bone formation and increases osteoblast proliferation and maturation and leads to the inhibition of osteoblast apoptosis. Therefore, a rapid and simple spectrofluorometric method has been developed and validated for the quantitative determination of it. Methods: The procedure is based on the reaction of primary amino group of alendronate with o-phthalaldehyde (OPA in sodium hydroxide solution. Results: The calibration graph was linear over the concentration range of 0.0-2.4 μM and limit of detection and limit of quantification of the method was 8.89 and 29 nanomolar, respectively.The enthalpy and entropy of the reaction between alendronate sodium and OPA showed that the reaction is endothermic and entropy favored (ΔH = 154.08 kJ/mol; ΔS = 567.36 J/mol K which indicates that OPA interaction with alendronate is increased at elevated temperature. Conclusion: This simple method can be used as a practical technique for the analysis of alendronate in various samples.

  20. Histomorphometry of the organic matrix of the femur in ovariectomized rats treated with sodium alendronate

    Directory of Open Access Journals (Sweden)

    Patricia Tanios Haddad

    2015-02-01

    Full Text Available OBJECTIVE: To evaluate the effect of two different concentrations of sodium alendronate on the quantity of organic matrix in the femur of rats with estrogen suppression caused by ovariectomy.METHODS: Sixty-days-old Wistar rats (Rattus norvegicus were subjected to bilateral laparotomy to remove the ovaries. The animals were divided into a control group, in which they only underwent laparotomy; an ovariectomized group (OVX; an ovariectomized group treated with 1 mg/kg of alendronate (OVX 1 mg; and an ovariectomized group treated with 2 mg/kg of alendronate (OVX 2 mg. The rats received alendronate twice a week for 90 days. The left femur was then removed, fixed and processed for embedding in paraffin. Semi-serial sections stained with hematoxylin and eosin were used to determine the area occupied by organic bone matrix, by means of image analysis software. The animals' weights were obtained at the beginning and end of the experiment.RESULTS: The ovariectomized animals and those treated with 1 mg/kg of alendronate presented significant increases in body weight (p 0.05 to that of the non-ovariectomized control animals (2,04,800 ± 9590, which indicates that this medication had a preventive effect with regard to bone mass loss.CONCLUSION: The higher concentration of the medication, administered twice a week for 90 days, was more effective than the dose of 1 mg/kg over the same period.

  1. Probing the Limits of Reality: The Metaphysics in Science Fiction.

    Science.gov (United States)

    Taylor, John L.

    2003-01-01

    Addresses metaphysical questions concerning the ultimate structure of reality and discusses scientific nature. Suggests that the world cannot afford to neglect the role of conceptual analysis in thinking critically about the possibilities that science fiction claims to describe. (Author/KHR)

  2. Peirce’s Scientific and Spiritual Process Metaphysics

    DEFF Research Database (Denmark)

    Brier, Søren

    Peirce saw as his primary task to develop a comprehensive metaphysical and epistemological system in which a new theory of categories, developed after Kant and Hegel, was defined in a completely new way. His triadic category theory was connected to a dynamic triadic web of semiotics viewed as the...

  3. Metaphysical Modality, Modality of Predicate and the Theory of

    Directory of Open Access Journals (Sweden)

    l nabavi

    2010-05-01

    This paper discusses the historical overview of the metaphysical modality firstly and then shows that the theory of "Decisive Necessity” is true and justified in a model of modal logic with equivalent accessibility relation and homogeneous possible world view (fixed domain.

  4. Preparation and Biological Study of 68Ga-DOTA-alendronate

    Science.gov (United States)

    Fakhari, Ashraf; Jalilian, Amir R.; Johari-Daha, Fariba; Shafiee-Ardestani, Mehdi; Khalaj, Ali

    2016-01-01

    Objective(s): In line with previous research on the development of conjugated bisphosphonate ligands as new bone-avid agents, in this study, DOTA-conjugated alendronate (DOTA-ALN) was synthesized and evaluated after labeling with gallium-68 (68Ga). Methods: DOTA-ALN was synthesized and characterized, followed by 68Ga-DOTA-ALN preparation, using DOTA-ALN and 68GaCl3 (pH: 4-5) at 92-95° C for 10 min. Stability tests, hydroxyapatite assay, partition coefficient calculation, biodistribution studies, and imaging were performed on the developed agent in normal rats. Results: The complex was prepared with high radiochemical purity (>99% as depicted by radio thin-layer chromatography; specific activity: 310-320 GBq/mmol) after solid phase purification and was stabilized for up to 90 min with a log P value of -2.91. Maximum ligand binding (65%) was observed in the presence of 50 mg of hydroxyapatite; a major portion of the activity was excreted through the kidneys. With the exception of excretory organs, gastrointestinal tract organs, including the liver, intestine, and colon, showed significant uptake; however, the bone uptake was low (<1%) at 30 min after the injection. The data were also confirmed by sequential imaging at 30-90 min following the intravenous injection. Conclusion: The high solubility and anionic properties of the complex led to major renal excretion and low hydroxyapatite uptake; therefore, the complex failed to demonstrate bone imaging behaviors. PMID:27408898

  5. Preparation and biological studies of 68Ga-DOTA-alendronate

    Directory of Open Access Journals (Sweden)

    Ashraf Fakhari

    2016-07-01

    Full Text Available Objective(s: In line with previous research on the development of conjugated bisphosphonate ligands as new bone-avid agents, in this study, DOTA conjugated alendronate (DOTA-ALN was synthesized and evaluated after labeling with gallium-68 (68Ga.Methods: DOTA-ALN was synthesized and characterized, followed by 68Ga-DOTA-ALN preparation, using DOTA-ALN and 68GaCl3 (pH: 4-5 at 92-95°C for 10 min. Stability tests, hydroxyapatite assay, partition coefficient calculation,biodistribution studies, and imaging were performed on the developed agent in normal rats.Results: The complex was prepared with high radiochemical purity (>99% as depicted by radio thin-layer chromatography; specific activity: 310-320GBq/mmol after solid phase purification and was stabilized for up to 90 min with a logP value of -2.91. Maximum ligand binding (65% was observed in the presence of 50 mg of hydroxyapatite; a major portion of the activity was excreted through the kidneys. With the exception of excretory organs, gastrointestinal tract organs, including the liver, intestine, and colon, showed significant uptake; however, the bone uptake was low (

  6. Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction

    Directory of Open Access Journals (Sweden)

    PPY Lui

    2013-01-01

    Full Text Available Peri-tunnel bone loss after anterior cruciate ligament (ACL reconstruction is commonly observed, both clinically and experimentally. We aimed to study the effect and mechanisms of different doses of alendronate in the reduction of peri-tunnel bone loss and promotion of graft-bone tunnel healing in ACL reconstruction. Eighty-four ACL-reconstructed rats were divided into 4 groups. Alendronate at different dosages, or saline, were injected subcutaneously weekly, for 2 or 6 weeks post-reconstruction, for vivaCT (computed tomography imaging, biomechanical tests, histology and immunohistochemistry. Alendronate significantly increased bone mass and density of tissue inside bone tunnels except at the epiphyseal region of tibial tunnel. The femoral tunnel diameter decreased significantly in the mid-dose and high-dose alendronate groups compared to that in the saline group at week 6. Alendronate significantly increased the peri-tunnel bone mass and density along all tunnel regions at week 6. Better graft-bone tunnel integration and intra-tunnel graft integrity were observed in the alendronate groups. The ultimate load was significantly higher in the mid-dose and high-dose alendronate groups at week 2, but not at week 6. There was a reduction in matrix metalloprotein (MMP1, MMP13 and CD68-positive cells at the peri-tunnel region and graft-bone interface in the alendronate-treated group compared to the saline group. Alendronate reduced peri-tunnel bone resorption, increased mineralised tissue inside bone tunnel as well as histologically and biomechanically promoted graft-bone tunnel healing, probably by reducing the expression of MMP1, MMP13 and CD68-positive cells. Alendronate might be used for reducing peri-tunnel bone loss and promoting graft-bone tunnel healing at early stage post-ACL reconstruction.

  7. Can classic metaphyseal lesions follow uncomplicated caesarean section?

    Energy Technology Data Exchange (ETDEWEB)

    O' Connell, AnnaMarie [Children' s University Hospital, Radiology Department, Dublin 1 (Ireland); Donoghue, Veronica B. [Children' s University Hospital, Radiology Department, Dublin 1 (Ireland); National Maternity Hospital, Radiology Department, Dublin (Ireland)

    2007-05-15

    Classic metaphyseal lesion (CML) is the term given to a fracture that most often occurs in the posteromedial aspect of the distal femur, proximal tibia, distal tibia, and proximal humerus in infants; this finding is strongly associated with non-accidental injury. To demonstrate that the CML may occur following simple lower segment caesarean section (LSCS). A review of 22 years of an obstetric practice that delivers 8,500 babies per year. We identified three neonates born by elective LSCS, each with distal femoral metaphyseal fractures on postpartum radiographs. All caesarean sections were elective and uncomplicated. External cephalic version was not employed preoperatively. Postpartum radiographs demonstrated a fracture of the distal femoral metaphysis in each neonate, typical of a CML. We propose that a CML can occur in the setting of a simple, elective and uncomplicated LSCS where no external cephalic version is employed. (orig.)

  8. Internal Realism: Putnam\\'s Alternative to Metaphysical Realism

    Directory of Open Access Journals (Sweden)

    J Akbari Takhtameshlou

    2014-03-01

    Having introduced and reviewed Putnam's arguments in rejecting metaphysical realism, this article explains and examines the basic elements of internal realism. The results of this article show that Putnam's objections against metaphysical realism lack the necessary credibility and strength and at the same time his proposed alternative (internal realism has serious problems that made to be addressed. By his chosen conception of truth, internal realism, cannot touch its stated purpose i.e. the removal of a huge gap between the truth of a statement and our knowledge of it. The ontological claims of internal realism are not, indeed, the reliable and true consequences of the thesis of conceptual relativity, which is considered as Putnam’s main base in this regard, but rather it is more a consequence of mistaking the linguistic issues with ontological ones.

  9. Science and Metaphysics in the Three Religions of the Book

    OpenAIRE

    Toby E. Huff

    2000-01-01

    The three religions of the Book trace their origins back to the same Abrahamic experience, but only one, Christianity, developed a metaphysical framework consistent with that of modern science. Both Judaism and Islam during their formative years, and continuously up to modern times, considered Greek philosophy and science alien wisdom, jeopardizing their sacred scriptures. The different path followed by Christianity is due to the influence of Hellenistic thought during Christianity's early fo...

  10. Minimally invasive plate osteosynthesis in metaphyseal fractures of tibia

    Directory of Open Access Journals (Sweden)

    K Ramesh Krishna

    2015-01-01

    Full Text Available Introduction: Treating tibial metaphyseal fractures is still great challenge. However, two of most used techniques are locked intramedullary nail and minimally-invasive bridge plate. Minimally invasive plate osteosynthesis (MIPO offers biological advantages. Reduced soft tissue dissection and exposition results in low surgical trauma and preservation of blood supply. Aim of study was to evaluate results of MIPO in treatment of metaphyseal fractures of tibia and to compare efficacy in treating metaphyseal fractures of tibia with other similar studies. Materials and Methods: This study was performed with 30 metaphyseal fractures of tibia with MIPO in hospitals attached to BMCRI. All cases were fresh fractures and traumatic. There were 12 proximal tibial and 18 distal tibial fractures. Temporary joint spanning external fixation was used for severe soft tissue injuries in 6 patients. All the fractures were stabilized by minimally invasive plating. Cases were followed up for an average of 14.1 months. Results: All fractures united. Proximal and disal tibia fractures united after an average of 6.3 and 6.6 months respectively. In proximal and distal tibia fractures, average range of motion achieved was 81.75° and 48.8° respectively. One patient with distal tibia fracture had a malunion with valgus alignment of more than 5°. Conclusion: Minimally invasive percutaneous plating facilitates in early mobilization of the patient which helps in healing of the fracture and prevents joint stiffness. It promotes early union as it does not disturb anatomy and physiology of vascularity at fracture site. There is minimal risk of infection and minimal blood loss.

  11. Langerhans cell histiocytosis case with dense metaphyseal band sign.

    Science.gov (United States)

    Kikkawa, Ichiro; Aihara, Toshinori; Morimoto, Akira; Watanabe, Hideaki; Furukawa, Rieko

    2013-02-01

    Eosinophilic granuloma, a type of Langerhans cell histiocytosis, exhibits a classic vertebral collapse, which is called vertebra plana (Calve's disease) and it manifests as a solitary bony lesion. Vertebra plana can cause severe pain in patients. Bisphosphonates (clodronate, pamidronate and zoledronic acid) have been recently used to treat osteolytic bone lesions of LCH. Zoledronic acid has 100 times relative potency that of pamidronate. We report a case of a 10-year-old girl who had zoledronic acid treatment for severe back pain due to vertebra plana. X-ray photographs of the patient's body showed dense metaphyseal band sign, which can be found in lead poisoning, treated leukemia, healing rickets, recovery from scurvy, vitamin D hypervitaminosis, congenital hypothyroidism and hypoparathyroidism. Increased biological potent zoledronic acid deprived her of severe back pain due to vertebra plana and might cause dense metaphyseal band sign of her skeleton. Conclusion; We have cured the severe back pain of a 10-year-old girl case of eosinophilic granuloma with zoledronic acid. After that treatment, X-ray photographs of the patient's body showed dense metaphyseal band sign. There have been few such cases reported until now. PMID:23409985

  12. Effect of insulin combined alendronate sodium on bone mineral density and levels of serum BAP, TRAP-5b and BGP in aged patients with type 2 diabetes mellitus with osteoporosis

    Institute of Scientific and Technical Information of China (English)

    Fang Wang; Han-Qiang Ren; Xiao-Bo Shen

    2016-01-01

    Objective:To explore the effect of insulin combined alendronate sodium on bone mineral density and levels of serum BAP, TRAP-5b and BGP in aged patients with type 2 diabetes mellitus with osteoporosis.Methods: A total of 136 patients with type 2 diabetes mellitus with osteoporosis in January 2014 to January 2016 in our hospital for the treatment were selected, and randomly divided into 4 groups, each of 40 cases. Caltrate D was given as a basic treatment to all the patients, and the control group was given the treatment of insulin, and the metformin group was given the treatment of metformin, and the combination group was given the treatment of metformin combined alendronate, and the experiment group was given the treatment of insulin combined alendronate. BMD of the femoral neck and the serum levels of BAP, TRAP-5b and BGP were detected and recorded before the treatment and after one year’s treatment.Results:On index of bone mineral density, the control group and the metformin group showed no significant differences; the combination group was slightly improved, but showed no statistical significance; After the treatment, the bone mineral density of the experiment was significantly improved. On index of bone turnover, the levels of serum BAP and BGP all had been improved and the level of TRAP-5b all was reduced then before the treatment in the control group, the combination group and the experiment group, but only the experiment group showed significant differences; On index of bone turnover, the experiment group were better than other groups, the differences were statistical significant.Conclusions:It has greater clinical curative effect that insulin combined alendronate sodium in the treatment of aged patients with type 2 diabetes mellitus with osteoporosis, it can effectively balance the metabolism of bone, safe and reliable, and it is worthy of application.

  13. Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Eiken, Pia; Prieto-Alhambra, Daniel;

    2016-01-01

    OBJECTIVES: To determine the skeletal safety and efficacy of long term (≥10 years) alendronate use in patients with osteoporosis. DESIGN: Open register based cohort study containing two nested case control studies. SETTING: Nationwide study of population of Denmark. PARTICIPANTS: 61 990 men and w...

  14. Characteristics of patients who suffer major osteoporotic fractures despite adhering to alendronate treatment

    DEFF Research Database (Denmark)

    Abrahamsen, B; Rubin, Katrine Hass; Eiken, Pia Agnete;

    2013-01-01

    Antiresorptive treatment reduces the risk of fractures, but most patients remain at elevated risk. We used health registers to identify predictors of new major osteoporotic fractures in patients adhering to alendronate. Risk factors showed a different pattern than in the general population and in...

  15. Healing properties of allograft from alendronate-treated animal in lumbar spine interbody cage fusion.

    Science.gov (United States)

    Xue, Qingyun; Li, Haisheng; Zou, Xuenong; Bünger, Mathias; Egund, Niels; Lind, Martin; Christensen, Finn Bjarke; Bünger, Cody

    2005-04-01

    This study investigated the healing potential of allograft from bisphosphonate-treated animals in anterior lumbar spine interbody fusion. Three levels of anterior lumbar interbody fusion with Brantigan cages were performed in two groups of five landrace pigs. Empty Brantigan cages or cages filled with either autograft or allograft were located randomly at different levels. The allograft materials for the treatment group were taken from the pigs that had been fed with alendronate, 10 mg daily for 3 months. The histological fusion rate was 2/5 in alendronate-treated allograft and 3/5 in non-treated allograft. The mean bone volume was 39% and 37.2% in alendronate-treated or non-treated allograft (NS), respectively. No statistical difference was found between the same grafted cage comparing two groups. The histological fusion rate was 7/10 in all autograft cage levels and 5/10 in combined allograft cage levels. No fusion was found at all in empty cage levels. With the numbers available, no statistically significant difference was found in histological fusion between autograft and allograft applications. There was a significant difference of mean bone volume between autograft (49.2%) and empty cage (27.5%) (P<0.01). In conclusion, this study did not demonstrate different healing properties of alendronate-treated and non-treated allograft for anterior lumbar interbody fusion in pigs. PMID:15248057

  16. Formulation of gastroresistant tablets containing sodium alendronate-loaded blend microparticles

    Directory of Open Access Journals (Sweden)

    Luana Mota Ferreira

    2015-06-01

    Full Text Available Sodium alendronate is an antiresorptive drug used for the treatment of postmenopausal osteoporosis. However, its oral administration is associated with low bioavailability and gastroesophageal irritation. This work aimed at developing tablets containing sodium alendronate-loaded microparticles by direct compression to achieve a safe and effective form. The parameters evaluated were average weight, hardness, thickness and drug content. In vitro release tests were carried out using simulated gastric and intestinal fluids, and the profiles were analyzed through the Korsmeyer-Peppas mono- or biexponential dependent approaches. Tablets presented adequate average weight, thickness, good mechanical properties and drug content close to 100%. Moreover, the formulation released less than 11% of sodium alendronate in gastric fluid, exhibiting a good gastroresistance. At pH 6.8, almost 100% of the drug was released in 12h, showing a prolonged profile. The mathematical modeling indicated that the experimental data was better fitted to the biexponential equation. Furthermore, a good correlation coefficient was obtained for the Korsmeyer-Peppas model and the release exponent suggested that the drug dissolution was driven by anomalous transport. In conclusion, the microparticulated tablets can be considered a promising alternative for oral delivery of sodium alendronate.

  17. Metaphysics in China and in the West:Common Origin and Later Divergence

    Institute of Scientific and Technical Information of China (English)

    Zhao Dunhua

    2006-01-01

    There are two tendencies in the arguments of the legitimacy of metaphysics in ancient China:the tendency to argue that there was no metaphysics in ancient China and the tendency to argue that ancient Chinese metaphysics is totally different from that of the West.In this article,the author counters these tendencies and argues that Chinese and western metaphysics both originated from a dynamic cosmology and shared objects of investigation and characteristics of thinking in terms of Becoming.However,in their later development,due to the difference in the problems of their focus,traditions of "moral metaphysics" and "(natural) metaphysics of Being" were formed in China and in the West,respectively.The author also explores the reasons for the rise of modem science in the West and its lack of progress in China.

  18. Johann Christoph Sturm's universal mathematics and metaphysics (German Title: Universalmathematik und Metaphysik bei Johann Christoph Sturm)

    Science.gov (United States)

    Leinsle, Ulrich G.

    In order to understand Sturm's concept of a universal mathematics as a replacement or complement of metaphysics, one first has to examine the evolution of the idea of a mathesis universalis up to Sturm, and his concept of metaphysics. According to the understanding of those times, natural theology belongs to metaphysics. The last section is concerned with Sturm's statements on the existence of God and his assessments for a physico-theology.

  19. The Evolution of Galaxies: A Metaphysics Viewpoint

    CERN Document Server

    Schombert, J M

    2004-01-01

    This is the written version of an invited review talk for the 13 Feb 2004 AAAS Meeting in Seattle. The talk's goal is to present a philosophical view of extragalactic astronomy as it applies to the sub-field of galaxy evolution. The talk is divided into three parts: 1) How we got to where we are (technology drivers to our science goals), 2) What's new and special (how that technology has achieved our recent science results) and 3) How an improved worldview will help us in the near future. The intended audience for this talk is a generally knowledgeable scientist, but not an astronomer by training. This talk is also not intended to be a complete review of the field of galaxy evolution and only includes a few recent results extracted from the astro-ph archives to present the current state of our field.

  20. Science and Metaphysics in the Three Religions of the Book

    Directory of Open Access Journals (Sweden)

    Toby E. Huff

    2000-12-01

    Full Text Available The three religions of the Book trace their origins back to the same Abrahamic experience, but only one, Christianity, developed a metaphysical framework consistent with that of modern science. Both Judaism and Islam during their formative years, and continuously up to modern times, considered Greek philosophy and science alien wisdom, jeopardizing their sacred scriptures. The different path followed by Christianity is due to the influence of Hellenistic thought during Christianity's early formative period. Both Judaism and Islam were spared the direct mediation of Greek culture and ideas because both Judaism and Islam developed geographically and linguistically isolated from the Greek influences during the reception of their scriptures.

  1. Like an Image: Sensibility and Reflexivity in Descartes’ Metaphysics

    Directory of Open Access Journals (Sweden)

    Augustin Dumont

    2014-06-01

    Full Text Available This paper aims at questioning the role of image and imagination in Descartes’ Metaphysics, especially in the Meditations on First Philosophy, by holding both a certain doctrinal or theoretical discourse on image/imagination and the Cartesian use of images/imagination. Besides the fact that this rarely considered perspective prevents from freezing the original text, this strategy allows to highlight the ambiguity of theses notions, revealed through what is doing by the act of imagining compared to the act of conceiving with the understanding.

  2. The will: from metaphysical freedom to normative functionalism.

    Science.gov (United States)

    Felthous, Alan R

    2008-01-01

    Free will is regarded by some as the most and by others as the least relevant concept for criminal responsibility. Contributions from religious and philosophical thinkers over the classical and medieval Christian eras demonstrate that, despite the passionate and historically consequential debates over the meaning of "freedom," the unifying theme that joined the will with the intellect remained persistent and pervasive. Leading historical jurists in England eventually dropped the descriptor "free," but retained the central importance of the will to criminal responsibility and emphasized its dependence on the intellect to function properly. Modern rationalist philosophers denied the will's metaphysical freedom, but not its existence. Today the neurosciences reveal more and more about how the will functions, even as lawyers and psychiatrists hesitate to utter the word. In properly avoiding metaphysical freedom within forensic inquiry and discourse, it is a grave conceptual mistake to overlook the will itself. Once greater conceptual clarity on the empirical nature of the will is achieved and accepted, the law itself could rediscover the core mental faculty behind human agency, the will.

  3. Metaphyseal cortical irregularities in children: A new perspective on a multi-focal growth variant

    International Nuclear Information System (INIS)

    The occurrence of metaphyseal cortical irregularities in adolescents in many different bones indicates a commonality of these lesions as a variation of normal growth, rater than a stress or avulsive by-product. The histologically recognized incomplete nature of the metaphysical cortex in children offers an attractive explanation for this phenomenon. (orig.)

  4. Serial MR findings of metaphyseal cyst in Legg-Calve-Perthes disease: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Chang Min; Na, Jae Boem; Moon, Haeng Jin [Gyeongsang National Univ., College of Mdicine, Chinju (Korea, Republic of)

    2001-11-01

    Metaphyseal cysts are common findings in Lee-Calve-Perthes(LCP) disease, though usually disappear within 6-12 months several studies have described the MR imaging findings of these cysts, though serial MRI findings have not been documented. In this report, therefore, we report the serial MRI results of metaphyseal cyst in LCP patients.

  5. Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate

    OpenAIRE

    Chen YC; Ho HO; Chiu CC; Sheu MT

    2013-01-01

    Ying-Chen Chen,1,* Hsiu-O Ho,1,* Chiao-Chi Chiu,1 Ming-Thau Sheu1,2 1School of Pharmacy, College of Pharmacy, Taipei Medical University, 2Clinical Research Center and Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei, Taiwan*These authors contributed equally to this workAbstract: In this study, alendronate, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastroretentive dosage form (GRDF) tablets to enhance its oral bioav...

  6. The Effect of Alendronate Treatment on Bone Density and Bone Markers in Postmenopausal Osteoporosis

    Directory of Open Access Journals (Sweden)

    S. Akı

    2002-03-01

    Full Text Available The objective of this blind, randomized controlled study was to evaluate effect of 12 months alendronate treatment on bone mineral density (BMD and bone formation, resorption markers in postmenopausal osteoporotic women. Women with BMD values at least 2 standard deviations (SD below BMD of adult premenopousal women were included in the study. Patients were randomized into two groups. The control group (n=ll2 received 500 mg daily elemental calcium, while the treatment group (n=l58 received 10 mg alendronate plus 500 mg daily elemental calcium for 12 months. Patient demographics were comparable in both groups before treatment. After 12 months, BMD of patients in alendronate group was increased significantly as compared to BMD before treatment and BMD in control group (p<0.001 . Increase in BMD was apparent in all measured sites but highest values were attained in the Ll-L4 region with 4.8 %. Bone formation and resorption parameters showed significant decrease in the 6 th and 12 th months of treatment as compared to control group and values before treatment (-23.1% to - 50.6 %. As a conclusion, twelve months treatment of alendronate (10 mg/day in postmenopausal osteoporotic women causes a significant increase of BMD in all measurement sites, as compared to BMD values before treatment and BMD of control group. Likewise bone formation and resorption markers showed significant decrease in the 6 th and 12 th months of treatment as compared to values in the control group and values before treatment.

  7. Healing properties of allograft from alendronate-treated animal in lumbar spine interbody cage fusion

    OpenAIRE

    Xue, Qingyun; Li, Haisheng; Zou, Xuenong; Bünger, Mathias; Egund, Niels; Lind, Martin; Christensen, Finn Bjarke; Bünger, Cody

    2004-01-01

    This study investigated the healing potential of allograft from bisphosphonate-treated animals in anterior lumbar spine interbody fusion. Three levels of anterior lumbar interbody fusion with Brantigan cages were performed in two groups of five landrace pigs. Empty Brantigan cages or cages filled with either autograft or allograft were located randomly at different levels. The allograft materials for the treatment group were taken from the pigs that had been fed with alendronate, 10 mg daily ...

  8. The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits

    OpenAIRE

    Jensen, Pia Rosgaard; Andersen, Thomas Levin; Pennypacker, Brenda L; Duong, Le T.; Delaissé, Jean-Marie

    2013-01-01

    Odanacatib (ODN) is a bone resorption inhibitor which differs from standard antiresorptives by its ability to reduce bone resorption without decreasing bone formation. What is the reason for this difference? In contrast with other antiresorptives, such as alendronate (ALN), ODN targets only the very last step of the resorption process. We hypothesize that ODN may therefore modify the remodeling events immediately following osteoclastic resorption. These events belong to the reversal phase and...

  9. The parody in Death and the Compass by Jorge Luis Borges as a Metaphysical Detective Novel

    Institute of Scientific and Technical Information of China (English)

    李胜楠

    2014-01-01

    The emergence of metaphysical detective novels changed the situation that traditional detective novels are often criticized as vulgar literature for its escaping from reality and its purpose of recreation and stimulus. Jorge Luis Borges is one of the forerunners of metaphysical detective fiction. Especially, some of his short novels become the classics of metaphysical detective novels. In this thesis, I will try to analyze the parody of one of Jorge Luis Borges’ representative metaphysical detective novels -“Death and the Compass” to see the main differences between metaphysical detective novels and traditional detective novels. This thesis is divided into three parts. Chapter one gives brief introduction about traditional detective novels. Chapter two discusses the parody in this novel. And chapter three comes to the conclusion which gives the reason for this change.

  10. Ulceração de anastomose esôfago-entérica causada por alendronato Esophagus-enteric anastomosis ulceration caused by alendronate

    Directory of Open Access Journals (Sweden)

    Pedro DUQUES

    2001-04-01

    could be present. Objective — Report a case of a patient who underwent total gastrectomy with Y-en-Roux anastomosis for a gastric carcinoid tumor and developed an esophagus-enteric anastomosis ulceration after the use of alendronate. Patient and Method — A 63-year-old woman started medical therapy with alendronate in a dose of 10 mg daily. After a period of one month of medical treatment with this drug she began to complain of dysphagic symptoms and abdominal pain. She was submitted to endoscopic examination that showed an esophageal ulceration, an enteric ulceration of the anastomosis and an esophageal stenosis. Results - Medical treatment with alendronate was discontinued and the symptom of abdominal pain desapeared. The intensity of dysphagia has decreased. The ulcerated lesion remitted although esophageal stenosis did not. The patient was subsequently treated with esophagus-enteric anastomosis dilation. She improved in her general state and nowadays she is free of symptoms. Conclusion — Alendronate sodium could cause lesions of the inferior esophageal portion or in distal segments of the gastrointestinal tube, in patients with a fast gastrointestinal transit. Special attention must be given to gastrectomized patients that use this drug because of the possibility to develop mucosal lesions in the enteric anastomosed part and its fearfull complications as stenosis.

  11. Effect of alendronate on skeletal uptake of technetium-99m MDP in a rat model

    International Nuclear Information System (INIS)

    Full text: Bisphosphonate compounds are now commonly used in the treatment of osteoporosis and their use is increasing in both myeloma and breast cancer patients. Whether bisphosphonates interfere with the uptake of bone seeking radiopharmaceuticals which have a similar chemical structure remains controversial. The effect of Alendronate on the uptake of methylene diphosphonate (MDP) was assessed in a group of 20 Wistar rats; 10 were given oral Alendronate approximately 1mg/kg/day for seven days against 10 controls. Four MBq 99Tcm-MDP was administered into a central vein under barbiturate anaesthesia. Four hours later samples of blood, thigh muscle and both femurs were obtained. These samples were weighed and the activity measured using a gamma counter then expressed as percent dose per gram of tissue. Mean activity, standard deviation and statistical significance were calculated for the blood, muscle and femurs. No significant difference was present in femoral activity, on comparison of the test and control groups at a significance level of 5%. In conclusion, oral Alendronate administration does not cause a significant reduction in the skeletal uptake of 99Tcm-MDP in rats, based on the sample size and dose used. A further 20 animals will be studied using a higher test dose of approximately 5mg/kg/day. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  12. Comparative in vitro study of oesophageal adhesiveness of different commercial formulations containing alendronate.

    Science.gov (United States)

    Shakweh, Monjed; Bravo-Osuna, Irene; Ponchel, Gilles

    2007-08-01

    Cases of oesophageal irritation have been reported in patients ingesting alendronate with little liquid or reclining shortly after taking the medication. Pill-induced oesophagitis principally occurs because of adherence of ingested tablets to the epithelial surface. The objective of this in vitro study was to evaluate the oesophageal bioadhesive characteristics of alendronate generics marketed in Europe, the proprietary Fosamax((R)), one negative and two positive polymer controls. A texture analyser was used for qualitative analysis and to determine the maximal detachment force and the adhesion work developed by each formulation on porcine oesophageal mucosa. Fosamax showed few or no bioadhesive characteristics, but the detachment of few tablets powder particles in some of the experiments does not preclude the potential risk of oesophageal lesions. The 10-mg generic Teva tablets had bioadhesive characteristics similar to a positive control. Other generic formulations (Alenat, Stada, Aliud, Ratiopharm showed "cleavage" rupture, leaving a large piece of the tablet mass attached to the mucosa. The bioadhesive characteristics seem to be related to the inactive ingredients: the presence of adhesive polymers such as HPC or very active disintegration agents, such as sodium croscarmellose. The demonstrated differences in adhesiveness suggest that differences in oesophageal tolerance between Fosamax tablets and generics of sodium alendronate may exist. PMID:17576054

  13. 阿仑膦酸钠普通片和肠溶片对绝经后女性骨质疏松骨代谢作用的比较%Comparison of bone metabolism in Chinese women with postmenopausal osteoporosis after alendronate sodium compressed tablets and alendronate enteric-coated tablets treatment

    Institute of Scientific and Technical Information of China (English)

    李朋梅; 刘晓; 崔刚; 车慧; 张相林

    2012-01-01

    Objective:To compare the effects of alendronate compressed tablets and alendronate enteric-coated tablets on bone metabolism in Chinese women with postmenopausal osteoporosis. Methods;In a randomized trial, 240 women with postmenopausal osteoporosis were enrolled, and divided into 2 groups. The patients in compressed tablets group ( n = 99 ) were treated with alendronate sodium compressed tablets combined with calcium for 6 months. The patients in enteric-coated tablets group (n = 102) were treated with alendronate sodium enteric-coated tablets combined with calcium for 6 months. Chang rate of total bone mineral density in lumbar spine 6 months later after alendronate treatment was assessed by DEXA. The serum levels of OC and CTX were measured and analyzed before and 6 months after treatment to evaluate the difference between the 2 alendronate preparations. Results ; In compressed tablets group, the change rate of total bone mineral density in lumbar spine 6 months after alendronate treatment was (4.03 ±8.21)% , and serum levels of OC and CTX significantly reduced (3.42 ±7.20) and (0.24 ±0.33) ng-mL , respectively. In enteric-coated tablets group,the change rate of total bone mineral density in lumbar spine 6 months after alendronate treatment was (4. 90 ±7. 41)% , and serum levels of OC andCTX significantly reduced (4. 33 ± 5. 54 ) and (0.26 ±0.28) ng·mL-1, respectively. Conclusions; The two alendronate preparations can significantly improve the bone metabolism in Chinese women with postmenopausal osteoporosis. No differences were observed in values of the 3 indicators including change rate of total bone mineral density in lumbar spine, serum levels of OC and CTX between the two groups.prove%目的:比较阿仑膦酸钠( ALN)普通片和肠溶片对绝经期后女性骨质疏松骨代谢的作用.方法:计划入组240例绝经后女性患者,1:1随机分成两组,分别以ALN普通片和肠溶片联合钙剂治疗6个月,用DEXA测定治疗

  14. Pragmatism, metaphysics, and bioethics: beyond a theory of moral deliberation.

    Science.gov (United States)

    Pamental, Matthew

    2013-12-01

    Pragmatism has been understood by bioethicists as yet another rival in the "methods wars," as yet another theory of moral deliberation. This has led to criticism of pragmatic bioethics as both theoretically and practically inadequate. Pragmatists' responses to these objections have focused mainly on misunderstandings of pragmatism's epistemology. These responses are insufficient. Pragmatism's commitment to radical empiricism gives it theoretical resources unappreciated by critics and defenders alike. Radical empiricism, unlike its more traditional ancestors, undercuts the gaps between theory and practice, and subjective and objective accounts of experience, and in so doing provides the metaphysical and epistemological basis for a thoroughgoing empirical naturalism in ethics. Pragmatism's strength as an approach to moral problems thus emerges as a result of a much wider array of resources than contemporary interpreters have acknowledged, which makes it a richer, deeper framework for understanding moral deliberation in general and bioethical decision making in particular. PMID:23878348

  15. Metaphysical and ethical perspectives on creating animal-human chimeras.

    Science.gov (United States)

    Eberl, Jason T; Ballard, Rebecca A

    2009-10-01

    This paper addresses several questions related to the nature, production, and use of animal-human (a-h) chimeras. At the heart of the issue is whether certain types of a-h chimeras should be brought into existence, and, if they are, how we should treat such creatures. In our current research environment, we recognize a dichotomy between research involving nonhuman animal subjects and research involving human subjects, and the classification of a research protocol into one of these categories will trigger different ethical standards as to the moral permissibility of the research in question. Are a-h chimeras entitled to the more restrictive and protective ethical standards applied to human research subjects? We elucidate an Aristotelian-Thomistic metaphysical framework in which to argue how such chimeras ought to be defined ontologically. We then examine when the creation of, and experimentation upon, certain types of a-h chimeras may be morally permissible.

  16. Evaluating the Metaphysical Realism of Étienne Gilson

    Directory of Open Access Journals (Sweden)

    Brian Kemple

    2015-12-01

    Full Text Available While there is an absence of treatises devoted to the question of ens ut primum cognitum, there is no shortage of brief and implicit treatments; indeed, nearly every Thomist of the past seven centuries seems to have at least something to say about the notion that being is the first of our intellectual conceptions. Most recent Thomist thinkers—including Gilson—assume this ens to be nothing other than the ens reale of things entitatively considered, operating as they do out of a framework within which realism and idealism are presumed to be exhaustive and mutually exclusive attempts to answer the question of human knowledge. It is the intent of this essay to examine how Gilson arrives at his position, which he calls “metaphysical realism,” and to point to some of the difficulties it entails.

  17. On Some Troubles with the Metaphysics of Fermionic Compositions

    Science.gov (United States)

    Bigaj, Tomasz

    2016-09-01

    In this paper I discuss some metaphysical consequences of an unorthodox approach to the problem of the identity and individuality of "indistinguishable" quantum particles. This approach is based on the assumption that the only admissible way of individuating separate components of a given system is with the help of the permutation-invariant qualitative properties of the total system. Such a method of individuation, when applied to fermionic compositions occupying so-called GMW-nonentangled states, yields highly implausible consequences regarding the number of distinct components of a given composite system. I specify the problem (which I call the problem of fermionic inflation) in detail, and I consider several strategies of solving it. The preferred solution of the problem is based on the premise that spatial location should play a privileged role in identifying and making reference to quantum-mechanical systems.

  18. Beauty and conservation: a metaphysical, pedagogical and ecclesiastical perspective

    Directory of Open Access Journals (Sweden)

    Mauro Mantovani

    2014-02-01

    Full Text Available After considering the notions of technology, art and culture, this essay presents a brief study on the metaphysical concept of beauty referring particularly to the thought of Thomas Aquinas and then proposing its application in an anthropological-pedagogical sphere. Focus then moves onto the philosophical concept of “conservation”. In this way the paper intends to show how Christian thought has necessarily deepened – in the light of the fundamental notions that belong to it – both the meaning of beauty, the artistic one included, and the concept of conservation and how these perspectives can represent in some way an interesting contribution for those who work in the field of conservation sciences or in the field of the planning and promotion of artistic and cultural events, especially if these events relate to religious heritage.

  19. Effect of Alendronate Vitamin D3 on Lipid Metabolism in Ovariectomized Rats with Osteoporosis%福美加对去势骨质疏松大鼠血脂代谢指标的影响

    Institute of Scientific and Technical Information of China (English)

    钱云峰; 孙伟珊; 魏秋实; 谭新; 邵玉; 邓伟民

    2013-01-01

    Objective To explore the effect of alendronate vitamin D3 on lipid metabolism in ovariectomized rats with osteoporosis.Methods Eighteen female non-pregnant SD rats (7 months old) were randomly divided into control group,ovariectomized group and alendronate vitamin D3 group.After eight weeks of treatment,the left femur and serum were collected to test the bone mineral content (BMC),bone mineral density (BMD) and lipid metabolism indexes.Results Compared with control and alendronate vitamin D3 group,the BMC and BMD of ovariectomized group were significantly decreased (P<0.05).There was no significant difference between the control group and alendronate vitamin D3 group.Compared with control and alendronate vitamin D3 group,the level of triglyceride (TG),cholesterol (CH) of ovariectomized group were significantly increased,and high density lipoprotein (HDL) level was significantly decreased (P<0.05).There was no significant difference between the control group and alendronate vitamin D3 group.Conclusion Lipid metabolism is abnormal in ovariectomized rat.Alendronate vitamin D3 can improve abnormal lipid metabolism status,and increase BMC and BMD.%目的 探讨福美加(阿仑膦酸钠维生素D3)对去势骨质疏松大鼠血脂代谢指标的影响.方法 18只7月龄SD雌性大鼠随机均分为对照组、模型组、福美加组.治疗8周后,收集左侧股骨和血清分别行骨矿含量(bone mineral content,BMC)、骨密度(bone mineral density,BMD)和血脂代谢指标检测.结果 模型组的骨矿含量和骨密度低于对照组(P<0.05),对照组与福美加组之间均数比较无统计学差异.模型组甘油三酯(triglyceride,TG)、胆固醇(cholesterol,CH)高于对照组和福美加组(P<0.05),高密度脂蛋白(high density lipoprotein,HDL)低于对照组和福美加组(P<0.05),对照组与福美加组之间均数比较无统计学差异.结论 去势大鼠存在血脂代谢异常,福美加可改善血脂代谢异常状态,提高骨矿含量和骨密度.

  20. MR evaluation of 'Metaphyseal' change in Legg-Calve-Perthes disease

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Haeng Jin; Na, Jae Boem; Shin, Chang Min; You, Jin Jong; Chung, Sung Hoon [Gyeongsang National Univ. College of Medicine, Chinju (Korea, Republic of)

    2001-06-01

    To determine the metaphyseal changes occurring in Legg-Calve-Perthes(LCP) disease using MRI. Between 1992 to 1999, 80 LCP patients (87 hips) underwent MR imaging and plain radiography. All MR images were reviewed, bone marrow signal intensity, the size and locatiion of the metaphyseal cyst and its epiphyseal necrosis grade determined. Metaphyses were abnormal in 43hips (49%), while bone marrow edema was present in 28 (32%) and a metaphyseal cyst in 30 (34%). Metaphyseal cysts were classified as either 'true' (n=9) or 'false' (n=21) according to the enhancement pattern. The maximum diameters of true and false cysts were 1.1{+-}0.3 cm and 1.1{+-}0.4 cm, respectively. Their most commom location was the anterior column; a true cyst occurred there in 7cases (78%), and false cyst in 16 (76%). Using the Waldenstrom classification, seven of the nine hips wih a true cyst (78%), were found to be at the avascular stage and 15 of the 21 with a false cyst (71%) were at the fragmentation stage. Seven of these nine (78%) and 19 of these 21 (90%) were Catterall grade IV. According to the findings of MR imaging, the metaphyseal changes occurring in LCP disease were bone marrow edema and metaphyseal cyst. This latter was visualized mainly in the anterior column and severely affected hip, and was classified as 'true' or 'false'.

  1. Relations between metaphysics and art? ¿Relaciones entre metafisica y arte?

    OpenAIRE

    Vélez León, Paulo

    2013-01-01

    International audience In this paper we intend to make visible a possible relationship between metaphysics and art, from the presuppose, in absolute terms they are the same, so that what you say is true of the metaphysical arts. However, the distinction between metaphysics and art is not feasible to show the world, especially in an artistic event such as a concert or show, but because the distinctions of the world. Try to address this issue since the concept of Sorge (cure, care) and metap...

  2. Production, quality control, biodistribution assessment and preliminary dose evaluation of 166Ho-alendronate as a bone marrow ablative agent

    International Nuclear Information System (INIS)

    In this study, production, quality control and biodistribution studies of 166Ho-alendronate have been presented and followed by dosimetric evaluation for human based on biodistribution data in wild-type rats. 166Ho chloride was obtained by thermal neutron irradiation of natural 165Ho(NO3)3 samples. 166Ho-alendronate complex was prepared by adding the desired amount of alkaline alendronate solution (0.2 mL, 150 mg/mL) to 3-5 mCi of the 166HoCl3 solution. Radiochemical purity of the complex was monitored by instant thin layer chromatography (ITLC). 166Ho-alendronate complex was prepared in high radiochemical purity (> 99%, ITLC) and specific activity of 4.4 GBq/mmol. Stability studies of the complex in the final preparation and in the presence of human serum were performed up to 48 h. The major accumulation of the radio-complex was in the bone tissues followed by absorbed dose evaluation of each human organ by RADAR software used for modelling the radiation dose delivered. The final preparation was administered to wild-type rats and biodistribution of the complex was performed 2-48 h post injection showing major accumulation of the complex in the bone tissue. The highest absorbed dose for 166Ho-alendronate is observed in bone surface and red marrow with 2.670 and 1.880 mSv/MBq; respectively. These findings suggest that 166Ho-alendronate has considerable characteristics compared to 166Ho-DOTMP and can be a possible candidate for bone marrow ablation in patients with multiple myeloma.

  3. Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice

    Directory of Open Access Journals (Sweden)

    Väänänen Kalervo

    2008-03-01

    Full Text Available Abstract Background Metastatic prostate cancer is associated with a high morbidity and mortality but the spreading mechanisms are still poorly understood. The aminobisphosphonate alendronate, used to reduce bone loss, has also been shown to inhibit the invasion and migration of prostate cancer cells in vitro. We used a modified orthotopic PC-3 nude mouse tumor model of human prostate cancer to study whether alendronate affects prostate tumor growth and metastasis. Methods PC-3 cells (5 × 105 were implanted in the prostates of nude mice and the mice were treated with alendronate (0.5 mg/kg/day in PBS, s.c. or vehicle for 4 weeks. After sacrifice, the sizes of tumor-bearing prostates were measured and the tumors and prostate-draining regional iliac and sacral lymph nodes were excised for studies on markers of proliferation, apoptosis, angiogenesis and lymphangiogenesis, using histomorphometry and immunohistochemistry. Results Tumor occurrence in the prostate was 73% in the alendronate-treated group and 81% in the control group. Mean tumor size (218 mm3, range: 96–485 mm3, n = 11 in the alendronate-treated mice was 41% of that in the control mice (513 mm3, range: 209–1350 mm3, n = 13 (p p p p Conclusion Our results demonstrate that alendronate treatment opposes growth of orthotopic PC-3 tumors and decreases tumor metastasis to prostate-draining lymph nodes. This effect could be at least partly explained by decreased angiogenesis and increased apoptosis. The results suggest that bisphosphonates have anti-tumoral and anti-invasive effects on primary prostate cancer.

  4. Effects of long-term alendronate treatment on bone mineralisation, resorption parameters and biomechanics of single human vertebral trabeculae

    Directory of Open Access Journals (Sweden)

    M Krause

    2014-09-01

    Full Text Available Due to their well-established fracture risk reduction, bisphosphonates are the most frequently used therapeutic agent to treat osteoporosis. Bisphosphonates reduce fracture risk by suppressing bone resorption, but the lower bone turnover could have a negative impact on bone quality at the tissue level. Here, we directly assess the structural and mechanical characteristics of cancellous bone from the lumbar vertebrae (L5 in non-treated osteoporotic controls (n = 21, mid-term alendronate-treated osteoporotic patients (n = 6, and long-term alendronate-treated osteoporotic patients (n = 7. The strength and toughness of single trabeculae were evaluated, while the structure was characterised through measurements of microdamage accumulation, mineralisation distribution, and histological indices. The alendronate-treated cases had a reduced eroded surface (ES/BS, p < 0.001 and a higher bone mineralisation in comparison to non-treated controls (p = 0.037, which is indicative of low turnover associated with treatment. However, the amount of microdamage and the mechanical properties were similar among the control and treatment groups. As the tissue mineral density (TMD increased significantly with alendronate treatment compared to non-treated osteoporotic controls, the reduction in resorption cavities could counterbalance the higher TMD allowing the alendronate-treated bone to maintain its mechanical properties and resist microdamage accumulation. A multivariate analysis of the possible predictors supports the theory that multiple factors (e.g., body mass index, TMD, and ES/BS can impact the mechanical properties. Our results suggest that long-term alendronate treatment shows no adverse impact on mechanical cancellous bone characteristics.

  5. A Case Against the Linguistic Approach to Metaphysics Zeno Vendler ’s Project and Beyond

    Institute of Scientific and Technical Information of China (English)

    DAI Xiao-ling

    2014-01-01

    There are two approaches to metaphysics that concern language, the logical and the linguistic. Zeno Vendler, who took the linguistic one, distinguished with transformational techniques between two semantic categories, namely fact and event, and regarded them as corresponding respectively to a metaphysical category of beings. In doing this he presupposed that indepen-dent semantic categories could be sorted out, and corresponding categories of beings that are independent of language can be de-rived. But our analysis of Vendler’s case shows that it is not semantic categories but grammar that functions in differentiating event and fact. At least some semantic categories could not be separated from grammar, and this casts doubt on the linguistic ap-proach to metaphysics. If semantic categories are not independent of grammar, we could not derive metaphysics from linguistic study.

  6. Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate

    Directory of Open Access Journals (Sweden)

    Chen YC

    2013-12-01

    Full Text Available Ying-Chen Chen,1,* Hsiu-O Ho,1,* Chiao-Chi Chiu,1 Ming-Thau Sheu1,2 1School of Pharmacy, College of Pharmacy, Taipei Medical University, 2Clinical Research Center and Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei, Taiwan*These authors contributed equally to this workAbstract: In this study, alendronate, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastroretentive dosage form (GRDF tablets to enhance its oral bioavailability. GRDF tablets were characterized with the effects of different molecular weights (MWs of chitosan (CS and hydroxyethyl cellulose (HEC at various ratios on swelling, floating, and physical integrity. The CS component was formed using various acids: acetic, lactic, malic, succinic, and citric, and a high viscosity grade of HEC was selected. The results demonstrated that the swelling ratios of the formulations comprising high MW CS were lower than those of low or medium MW CS when salts were formed with any countering acids except for acetic acid. The decreasing ranking of the swelling rates was: CS-citrate > CS-malate > CS-lactate > CS-succinate > CS-acetate. A negative correlation was found between the pKa of the respective countering acid and the swelling rate. The swelling rate was promoted if an acidic salt of CS with a lower water content was incorporated, while it became slower when tablet hardness was higher or the compression force to form tablets was increased. Although HEC did not contribute to swelling or floating, it played a role in maintaining structural integrity. A prolonged dissolution profile of alendronate GRDF tablets developed in this study was observed.Keywords: gastroretentive dosage form, chitosan, hydrogel, hydroxyethyl cellulose, swelling, alendronate

  7. Metaphysical conspiracism: UFOs as discursive object between popular millennial and conspiracist fields

    OpenAIRE

    Robertson, David George

    2014-01-01

    This thesis argues that narratives about Unidentified Flying Objects (UFOs) act as the central point of contact between conspiracist and popular millennial fields. Their confluence has come to form a field here termed ‘metaphysical conspiracism’, combining teleological narratives, the promise of soteriological knowledge and the threat of occluded malevolent agencies. I argue that metaphysical conspiracism offers a unique perspective on the interplay of knowledge, power and the ...

  8. Murk Jansen's metaphyseal chondrodysplasia with long-term follow-up

    Energy Technology Data Exchange (ETDEWEB)

    Silverthorn, K.G.; Houston, C.S.; Duncan, B.P.

    1987-02-01

    The fourteenth reported patient with Murk Jansen's metaphyseal chondrodysplasia is presented, with a remarkable followup from birth to the age of 15 years. Numerous invasive procedures were performed in pursuit of erroneous provisional diagnoses. Five of these patients presented in infancy with radiographic metaphyseal changes similar to rickets, but with preservation of the provisional zone of calcification. Following infancy, these patients reveal the more typical short-limbed dwarfism, with fusiform joints and bowed extremities.

  9. Pullulan: an advantageous natural polysaccharide excipient to formulate tablets of alendronate-loaded microparticles

    Directory of Open Access Journals (Sweden)

    Luana Mota Ferreira

    2015-03-01

    Full Text Available This work reports the preparation of tablets by direct compression of sodium alendronate-loaded microparticles, using pullulan as filler. The tableting properties of pullulan were compared with those of microcrystalline cellulose and lactose. Pullulan tablets showed low variations in average weight, thickness and drug content. Moreover, these tablets exhibited a higher hardness compared to the other excipients. In vitro release studies showed that only pullulan was capable to maintain gastroresistance and release properties of microparticles, due to its ability to protect particles against damage caused by compression force. Thus, pullulan was considered an advantageous excipient to prepare tableted microparticles.

  10. On Kinds of Indiscernibility in Logic and Metaphysics

    CERN Document Server

    Caulton, Adam

    2011-01-01

    Using the Hilbert-Bernays account as a spring-board, we first define four ways in which two objects can be discerned from one another, using the non-logical vocabulary of the language concerned. (These definitions are based on definitions made by Quine and Saunders.) Because of our use of the Hilbert-Bernays account, these definitions are in terms of the syntax of the language. But we also relate our definitions to the idea of permutations on the domain of quantification, and their being symmetries. These relations turn out to be subtle---some natural conjectures about them are false. We will see in particular that the idea of symmetry meshes with a species of indiscernibility that we will call `absolute indiscernibility'. We then report all the logical implications between our four kinds of discernibility. We use these four kinds as a resource for stating four metaphysical theses about identity. Three of these theses articulate two traditional philosophical themes: viz. the principle of the identity of indis...

  11. Fundamental awareness: A framework for integrating science, philosophy and metaphysics.

    Science.gov (United States)

    Theise, Neil D; Kafatos, Menas C

    2016-01-01

    The ontologic framework of Fundamental Awareness proposed here assumes that non-dual Awareness is foundational to the universe, not arising from the interactions or structures of higher level phenomena. The framework allows comparison and integration of views from the three investigative domains concerned with understanding the nature of consciousness: science, philosophy, and metaphysics. In this framework, Awareness is the underlying reality, not reducible to anything else. Awareness and existence are the same. As such, the universe is non-material, self-organizing throughout, a holarchy of complementary, process driven, recursive interactions. The universe is both its own first observer and subject. Considering the world to be non-material and comprised, a priori, of Awareness is to privilege information over materiality, action over agency and to understand that qualia are not a "hard problem," but the foundational elements of all existence. These views fully reflect main stream Western philosophical traditions, insights from culturally diverse contemplative and mystical traditions, and are in keeping with current scientific thinking, expressible mathematically. PMID:27489576

  12. Fundamental awareness: A framework for integrating science, philosophy and metaphysics.

    Science.gov (United States)

    Theise, Neil D; Kafatos, Menas C

    2016-01-01

    The ontologic framework of Fundamental Awareness proposed here assumes that non-dual Awareness is foundational to the universe, not arising from the interactions or structures of higher level phenomena. The framework allows comparison and integration of views from the three investigative domains concerned with understanding the nature of consciousness: science, philosophy, and metaphysics. In this framework, Awareness is the underlying reality, not reducible to anything else. Awareness and existence are the same. As such, the universe is non-material, self-organizing throughout, a holarchy of complementary, process driven, recursive interactions. The universe is both its own first observer and subject. Considering the world to be non-material and comprised, a priori, of Awareness is to privilege information over materiality, action over agency and to understand that qualia are not a "hard problem," but the foundational elements of all existence. These views fully reflect main stream Western philosophical traditions, insights from culturally diverse contemplative and mystical traditions, and are in keeping with current scientific thinking, expressible mathematically.

  13. Overcoming O: Dewey and the Problem of Bion's Metaphysics.

    Science.gov (United States)

    Soffer-Dudek, Nir

    2015-10-01

    Bion guides us to eschew memory, desire, and understanding in order to become one with O-the ultimate reality of the analytic moment. However, his directions are valid only to the extent that such a meta-reality actually exists. Otherwise there is nothing to unite with and no reason to shun memory or desire. The present work inquires whether we may provide Bion's technique with a less speculative philosophy, specifically Dewey's pragmatist theory of aesthetics. It begins with reviewing the similarities between the two writers' methods, highlighting their shared emphasis on openness to the unknown. Yet listening to their intonations reveals that they actually convey opposite ideas as to what this "unknown" may be. Whereas Dewey sanguinely portrays the possibilities of the "yet-unknown," Bion emphasizes the dread of our inescapable encounter with the unknowable. This dread is embodied in his concept of O. Thus, rather than being merely a metaphysical speculation, O communicates Bion's conviction that fear forms the core of our existence. Banishing O from the counseling room may indeed aid his method in becoming accessible to a wider audience; at the same time, however, doing so might also deprive it of the very context that gives it meaning. PMID:26487111

  14. Overcoming O: Dewey and the Problem of Bion's Metaphysics.

    Science.gov (United States)

    Soffer-Dudek, Nir

    2015-10-01

    Bion guides us to eschew memory, desire, and understanding in order to become one with O-the ultimate reality of the analytic moment. However, his directions are valid only to the extent that such a meta-reality actually exists. Otherwise there is nothing to unite with and no reason to shun memory or desire. The present work inquires whether we may provide Bion's technique with a less speculative philosophy, specifically Dewey's pragmatist theory of aesthetics. It begins with reviewing the similarities between the two writers' methods, highlighting their shared emphasis on openness to the unknown. Yet listening to their intonations reveals that they actually convey opposite ideas as to what this "unknown" may be. Whereas Dewey sanguinely portrays the possibilities of the "yet-unknown," Bion emphasizes the dread of our inescapable encounter with the unknowable. This dread is embodied in his concept of O. Thus, rather than being merely a metaphysical speculation, O communicates Bion's conviction that fear forms the core of our existence. Banishing O from the counseling room may indeed aid his method in becoming accessible to a wider audience; at the same time, however, doing so might also deprive it of the very context that gives it meaning.

  15. Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate.

    Science.gov (United States)

    Chen, Ying-Chen; Ho, Hsiu-O; Chiu, Chiao-Chi; Sheu, Ming-Thau

    2014-01-01

    In this study, alendronate, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastroretentive dosage form (GRDF) tablets to enhance its oral bioavailability. GRDF tablets were characterized with the effects of different molecular weights (MWs) of chitosan (CS) and hydroxyethyl cellulose (HEC) at various ratios on swelling, floating, and physical integrity. The CS component was formed using various acids: acetic, lactic, malic, succinic, and citric, and a high viscosity grade of HEC was selected. The results demonstrated that the swelling ratios of the formulations comprising high MW CS were lower than those of low or medium MW CS when salts were formed with any countering acids except for acetic acid. The decreasing ranking of the swelling rates was: CS-citrate > CS-malate > CS-lactate > CS-succinate > CS-acetate. A negative correlation was found between the pKa of the respective countering acid and the swelling rate. The swelling rate was promoted if an acidic salt of CS with a lower water content was incorporated, while it became slower when tablet hardness was higher or the compression force to form tablets was increased. Although HEC did not contribute to swelling or floating, it played a role in maintaining structural integrity. A prolonged dissolution profile of alendronate GRDF tablets developed in this study was observed. PMID:24403821

  16. Time trends for alendronate prescription practices in women with chronic obstructive pulmonary disease and women exposed to systemic glucocorticoids

    DEFF Research Database (Denmark)

    Brask-Lindemann, Dorthe; Eiken, P; Eskildsen, P;

    2013-01-01

    of alendronate treatment in patients with COPD and patients with systemic corticosteroid exposure. Introduction COPD and systemic glucocorticoid exposure are well-known risk factors of osteoporosis and fragility fracture, but osteoporosis is often underdiagnosed and undertreated in these patients. This study...

  17. 阿仑膦酸钠防治牙槽骨吸收的实验研究%The treatment of osteoporosis and bone resorption of alveoli with alendronate in rat model

    Institute of Scientific and Technical Information of China (English)

    王晓敏; 杨宗萍; 于世凤

    2001-01-01

    目的用骨质疏松及牙槽骨吸收动物模型评价阿仑膦酸盐对骨吸收的防治作用。方法建立骨质疏松及牙槽骨吸收的动物模型,建模手术次日,给实验组皮下注射阿仑膦酸钠液,每周3次,共6周。用血生化指标、骨生物力学、骨密度测量及组织形态学方法进行药效评价。结果股骨密度:对照组(0.123 g/cm2)与实验组(0.151 g/cm2)相比明显降低(P<0.01);血清碱性磷酸酶:对照组(259.63 U/L)与实验组(151.13 U/L)相比明显升高(P<0.01);骨生物力学各项指标,实验组与对照组也有明显差异。组织形态学:实验组牙龈轻度炎症,牙槽嵴顶未见明显吸收;对照组牙龈乳突炎症明显,上皮钉突增生,炎细胞浸润,牙槽嵴顶明显吸收。结论阿仑膦酸钠能减少骨质丢失从而可以防止骨质疏松及病理性牙槽骨骨吸收。%Objective To evaluate the anti-osteoporosis effect of alendronate on bone in rat model. Methods The osteoporosis and alveolar bone resorption animal model were established in rats. The experimental groups were given alendronate in 5 mg/kg BW by subcutaneous injection after first day of ovariectomy and dental ligature, three times a week for 6 weeks. All the animals were sacrifised 12 weeks after the operation. The blood samples were collected for determination of biochemical indices. The left femora and jaw bones were processed for histomorphometry. The right femora and mendibles were prepared for determination of bone density and bone biodynamics. Results As compared with the control groups(without alendronate), the values of experimental groups (with alendronate) were all significantly improved on bone density, bone anti-flexure ability and body weight. The alkaline phosphatase, calcium in serum of ovariectomy groups(without alendronate) were obviously increased. In the experimental group, however, these indices were close to normal levels. In

  18. Impaction grafting with morsellised allograft and tricalcium phosphate-hydroxyapatite: incorporation within ovine metaphyseal bone defects.

    Science.gov (United States)

    Pratt, J N J; Griffon, D J; Dunlop, D G; Smith, N; Howie, C R

    2002-08-01

    An ovine model was used to investigate the in vivo properties of impacted tricalcium phosphate-hydroxyapatite (TCP-HA) aggregates, varying in chemical composition (ratio of TCP to HA) and particle size distribution (8 versus 3 particle size ranges). All pellets were impacted to a standard compactive effort. Eight sheep underwent implantation of pellets in 4 metaphyseal defects in both rear limbs. Treatment groups consisted of: (1) allograft (clinical control). (2) 50/50 allograft/80% HA/20% TCP in 8 particle size ranges, (3) 50/50 allograft/80% TCP/20% HA in 8 sizes and (4) 50/50 allograft/80% HA/20% TCP in only 3 sizes of particles. Healing of defects was evaluated at 14 weeks with computed tomography, histology and histomorphometry. The computer tomography (CT) density measured in all defects containing synthetic agents was higher than in defects filled with allograft alone (p<0.01). Defects containing 8 sizes of 80% HA/ 20% TCP granules (group 2) achieved lower histological scores and contained less bone than the clinical control (p<0.05), whereas groups 3 and 4 did not differ from the control. Although all synthetic agents were osteoconductive, our results suggest that increasing the ratio of TCP over HA and limiting the number of particle size ranges to 3 instead of 8 improve the performance of impacted aggregates as graft expanders. Evaluation under loading conditions of morsellised allograft expanded with 80% TCP/20% HA (BoneSave) in 3 particle size ranges is warranted.

  19. The Effect of Local Delivery Doxycycline and Alendronate on Bone Repair.

    Science.gov (United States)

    Limirio, Pedro Henrique Justino Oliveira; Rocha, Flaviana Soares; Batista, Jonas Dantas; Guimarães-Henriques, João César; de Melo, Geraldo Batista; Dechichi, Paula

    2016-08-01

    The aim of the present study was to investigate the local effect of 10% doxycycline and 1% alendronate combined with poly(lactic-co-glycolic acid) (PLGA) on bone repair. Thirty rats were divided into three groups, as follows: control group (CG), drug group (DG), and vehicle-PLGA group (VG). Bone defect was created in the right femur and filled with the following: blood clot (CG); PLGA gel, 10% doxycycline and 1% alendronate (DG); or vehicle-PLGA (VG). The animals were euthanized 7 or 15 days after surgery. Bone density, bone matrix and number of osteoclasts were quantified. At 7 days, the findings showed increased density in DG (177.75 ± 76.5) compared with CG (80.37 ± 27.4), but no difference compared with VG (147.1 ± 41.5); no statistical difference in bone neoformation CG (25.6 ± 4.8), VG (27.8 ± 4), and DG (18.9 ± 7.8); and decrease osteoclasts in DG (4.6 ± 1.9) compared with CG (26.7 ± 7.4) and VG (17.3 ± 2.7). At 15 days, DG (405.1 ± 63.1) presented higher density than CG (213.2 ± 60.9) and VG (283.4 ± 85.8); there was a significant increase in percentage of bone neoformation in DG (31.5 ± 4.2) compared with CG (23 ± 4), but no difference compared with VG (25.1 ± 2.9). There was a decreased number of osteoclasts in DG (20.7 ± 4.7) and VG (29.5 ± 5.4) compared with CG (40 ± 9.4). The results suggest that the association of 10% doxycycline and 1% alendronate with PLGA-accelerated bone repair. PMID:26381914

  20. Some Aspects of the Metaphysics of Chemistry and the Nature of the Elements

    Directory of Open Access Journals (Sweden)

    Eric R. Scerri

    2005-11-01

    Full Text Available There is now a considerable body of published work on the epistemology of modern chemistry, especially with regard to the nature of quantum chemistry. In addition, the question of the metaphysical underpinnings of chemistry has received a good deal of attention. The present article concentrates on metaphysical considerations including the question of whether elements and groups of elements are natural kinds. It is also argued that an appeal to the metaphysical nature of elements can help clarify the re-emerging controversies among chemists regarding the placement of the elements hydrogen and helium in the periodic system and the question of whether there exists a best form of the periodic table.

  1. Comparative Study of Plating versus Nailing in Distal Tibia Metaphyseal Fractures

    Directory of Open Access Journals (Sweden)

    Jayesh V Vaza

    2014-12-01

    Full Text Available Distal tibial metaphyseal fracture are unique.we have studied 40 pt in sir j.j.hospital group of the hospitals from periods MAY 2009 and APRIL 2011 .The study prospective and comparative for the methods used for management of this fracture. The best option for surgical treatment of distal metaphyseal fractures of tibia is still unclear. The purpose of this study was, first, to confirm whether closed reduction and intramedullary nailing produces better results than open reduction and internal fixation with precontoured locked plate and screws and, second, to establish indications for each modality. The overall results were comparable and most patients were satisfied with the results. These results indicate that both modalities of treatment deserve a place in treating distal metaphyseal fractures of tibia. [Natl J Med Res 2014; 4(4.000: 340-344

  2. The effect of nitrogen containing bisphosphonates, zoledronate and alendronate, on the production of pro-angiogenic factors by osteoblastic cells.

    Science.gov (United States)

    Ishtiaq, S; Edwards, S; Sankaralingam, A; Evans, B A J; Elford, C; Frost, M L; Fogelman, I; Hampson, G

    2015-02-01

    Bisphosphonates (BPs) have been shown to influence angiogenesis. This may contribute to BP-associated side-effects such as osteonecrosis of the jaw (ONJ) or atypical femoral fractures (AFF). The effect of BPs on the production of angiogenic factors by osteoblasts is unclear. The aims were to investigate the effect of (1) alendronate on circulating angiogenic factors; vascular endothelial growth factor (VEGF) and angiopoietin-1 (ANG-1) in vivo and (2) zoledronate and alendronate on the production of VEGF and ANG-1 by osteoblasts in vitro. We studied 18 post-menopausal women with T score⩽-2 randomized to calcium/vitamin D only (control arm, n=8) or calcium/vitamin D and alendronate 70mg weekly (treatment arm, n=10). Circulating concentrations of VEGF and ANG-1 were measured at baseline, 3, 6 and 12months. Two human osteoblastic cell lines (MG-63 and HCC1) and a murine osteocytic cell line (MLO-Y4) were treated with zoledronate or alendronate at concentrations of 10(-12)-10(-6)M. VEGF and ANG-1 were measured in the cell culture supernatant. We observed a trend towards a decline in VEGF and ANG-1 at 6 and 12months following treatment with alendronate (p=0.08). Production of VEGF and ANG-1 by the MG-63 and HCC1 cells decreased significantly by 34-39% (p<0.01) following treatment with zoledronate (10(-9)-10(-6)M). Treatment of the MG-63 cells with alendronate (10(-7) and 10(-6)) led to a smaller decrease (25-28%) in VEGF (p<0.05). Zoledronate (10(-10)-10(-)(6)M) suppressed the production of ANG-1 by MG-63 cells with a decrease of 43-49% (p<0.01). Co-treatment with calcitriol (10(-8)M) partially reversed this zoledronate-induced inhibition. BPs suppress osteoblastic production of angiogenic factors. This may explain, in part, the pathogenesis of the BP-associated side-effects. PMID:25461393

  3. Seven years’ experience with alendronate in postmenopausal Japanese women with osteoporosis

    Directory of Open Access Journals (Sweden)

    Jun Iwamoto

    2010-04-01

    Full Text Available Jun Iwamoto1, Yoshihiro Sato2, Mitsuyoshi Uzawa3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Neurology, Mitate Hospital, Fukuoka, Japan; 3Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, JapanAbstract: A retrospective study was performed to evaluate the outcome of alendronate (ALN treatment for seven years in postmenopausal Japanese women with osteoporosis. Forty-seven postmenopausal women with osteoporosis (mean age at baseline 65.7 years treated with ALN for over seven years in our outpatient clinic were analyzed. Lumbar spine bone mineral density (BMD was measured using dual energy X-ray absorptiometry, and urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX and serum alkaline phosphatase (ALP were monitored during the seven-year treatment period. Urinary NTX and serum ALP levels decreased (-48.2% at three months and -15.7% at seven years, respectively and lumbar spine BMD increased (+12.8% at seven years compared with baseline values. No serious adverse events were observed, including osteonecrosis of jaw, atypical femoral diaphysis fractures, or atrial fibrillation. To our knowledge, this is the first report of the outcome of ALN treatment for seven years in Japanese patients with osteoporosis. ALN successfully suppressed bone turnover and increased lumbar spine BMD from the baseline value over the course of the seven-year treatment period without causing any severe adverse events.Keywords: alendronate, osteoporosis, long-term treatment, bone mineral density, bone turnover

  4. A Metaphysical Reflection on the Notion of Background in Modern Spacetime Physics

    CERN Document Server

    Vassallo, Antonio

    2016-01-01

    The paper presents a metaphysical characterization of spatiotemporal backgrounds from a realist perspective. The conceptual analysis is based on a heuristic sketch that encompasses the common formal traits of the major spacetime theories, such as Newtonian mechanics and general relativity. It is shown how this framework can be interpreted in a fully realist fashion, and what is the role of background structures in such a picture. In the end it is argued that, although backgrounds are a source of metaphysical discomfort, still they make a spacetime theory easy to interpret. It is also suggested that this conclusion partially explains why the notion of background independence carries a lot of conceptual difficulties.

  5. New type of spondylo-metaphyseal dysplasia - Algerian type. Report of five cases

    Energy Technology Data Exchange (ETDEWEB)

    Kozlowski, K.; Bacha, L.; Massen, R.; Ayati, M.; Sator, S.; Brahimi, L.

    1988-04-01

    A new, dominantly inherited, severe form of spondylometaphyseal dysplasia in five members of an Algerian family is reported. Another child, not investigated, was also probably affected. The disease is characterised by a unique clinical and radiological set of features: dwarfism, genu valgum deformity, progressive kypho-scoliosis, wrist deformity, myopia and severe metaphyseal dysplasia, with moderate spinal changes and minimal changes in the hands and feet. In view of the geographical localisation of the disorder and the anatomical distribution we propose the name Algerian type of spondylo-metaphyseal dysplasia.

  6. On How physics Could impact on the Metaphysics of Space and Time

    Directory of Open Access Journals (Sweden)

    Alireza Mansouri

    2015-03-01

    Full Text Available This paper aims to illustrate the mutual inter-relation of physics and metaphysics in the context of the philosophy of space and time. We especially emphasize, in this paper, that scientific development could impact on our position regarding the reality of space and time. To illustrate this point, we investigate the mutual inter-relation of physics and metaphysics in the modern developments of physics, i.e. neo-Newtonian structure, special and general relativity (GR. This paper ends up anticipating that it is likely, by considering modern physics, especially GR, that substantivalism to be a more defensible position.

  7. 大学与形而上品格%University and the Character of Metaphysics

    Institute of Scientific and Technical Information of China (English)

    张楚廷

    2011-01-01

    人的求知本性使人有走向形而上的可能。大学是让人现实地走向形而上的一条天路。故而,真正的大学必具有形而上的品格。健全的社会必定需要大学的这种品格。%The human being's natural instinct for knowledge makes himself possessed the possibility of pursuing metaphysics.And higher education offers the human being the sacred road towards metaphysics realistically.Therefore,a genuine university must take possess

  8. Effects of denosumab, alendronate, or denosumab following alendronate on bone turnover, calcium homeostasis, bone mass and bone strength in ovariectomized cynomolgus monkeys.

    Science.gov (United States)

    Kostenuik, Paul J; Smith, Susan Y; Samadfam, Rana; Jolette, Jacquelin; Zhou, Lei; Ominsky, Michael S

    2015-04-01

    Postmenopausal osteoporosis is a chronic disease wherein increased bone remodeling reduces bone mass and bone strength. Antiresorptive agents including bisphosphonates are commonly used to mitigate bone loss and fracture risk. Osteoclast inhibition via denosumab (DMAb), a RANKL inhibitor, is a newer approach for reducing fracture risk in patients at increased risk for fracture. The safety of transitioning from bisphosphonate therapy (alendronate; ALN) to DMAb was examined in mature ovariectomized (OVX) cynomolgus monkeys (cynos). One day after OVX, cynos (7-10/group) were treated with vehicle (VEH, s.c.), ALN (50 μg/kg, i.v., twice monthly) or DMAb (25 mg/kg/month, s.c.) for 12 months. Other animals received VEH or ALN for 6 months and then transitioned to 6 months of DMAb. DMAb caused significantly greater reductions in serum CTx than ALN, and transition from ALN to DMAb caused further reductions relative to continued ALN. DMAb and ALN decreased serum calcium (Ca), and transition from ALN to DMAb resulted in a lesser decline in Ca relative to DMAb or to VEH-DMAb transition. Bone histomorphometry indicated significantly reduced trabecular and cortical remodeling with DMAb or ALN. Compared with ALN, DMAb caused greater reductions in osteoclast surface, eroded surface, cortical porosity and fluorochrome labeling, and transition from ALN to DMAb reduced these parameters relative to continued ALN. Bone mineral density increased in all active treatment groups relative to VEH controls. Destructive biomechanical testing revealed significantly greater vertebral strength in all three groups receiving DMAb, including those receiving DMAb after ALN, relative to VEH controls. Bone mass and strength remained highly correlated in all groups at all tested skeletal sites, consistent with normal bone quality. These data indicate that cynos transitioned from ALN to DMAb exhibited reduced bone resorption and cortical porosity, and increased BMD and bone strength, without

  9. Role of connexin 43 in the mechanism of action of alendronate: dissociation of anti-apoptotic and proliferative signaling pathways

    OpenAIRE

    Lezcano, V; Bellido, T; LI, Plotkin; Boland, R; Morelli, S.

    2012-01-01

    Bisphosphonates (BPs) inhibit osteocyte and osteoblast apoptosis via opening of connexin (Cx) 43 hemichannels and activating the extracellular signal regulated kinases ERKs. Previously, we hypothesized that intracellular survival signaling is initiated by interaction of BPs with Cx43. However, using whole cell binding assays with [3H]-alendronate, herein we demonstrated the presence of saturable, specific and high affinity binding sites in the Cx43-expressing ROS 17/2.8 osteoblastic cells, au...

  10. 阿仑膦酸钠联合辛伐他汀对骨质疏松骨折的影响%Impact of alendronate combined with simvastatin on osteoporotic fractures

    Institute of Scientific and Technical Information of China (English)

    薛江义; 张晶晶; 卢向东; 徐彬

    2014-01-01

    To investigate the effects of alendronate combined with simvastatin on the osteoporotic fracture healing in rats.Methods 50 SD adult female rats were randomly divided into 5 groups:(A)sham operation control group;(B)ovariectomized control group;(C)ovariectomized alendronate group;(D)simvastatin group;(E) ovariectomized alendronate and simvastatin group.B,C,D,Egroup underwent ovariectomy surgery,A group only partially excised adipose tissue.8 weeks later,2 rats were selected randomly from each group to confirm osteoporosis successful modeling.Then the midshaft femur fracture model was established by an operation and intramedullary nails fixation was achieved with Kirschner wire.Deal each group of rats with such drug intervention as follows:(A,B) physiological saline 5mL/(kg·d)gavage for 8 weeks; (C)alendronate 0.5mg/(kg·d) gavage for 8 weeks;(D) simvastatin 20mg/(kg·d)gavage for 8 weeks (E)alendronate 0.5mg/(kg·d)+ simvastatin 20mg/(kg·d) gavage for 8 weeks.All the rats were killed and their blood samples and left femurs were collected.The serum calcium, phosphorus,alkaline phosphatase(ALP)content,X-ray bone mineral density(BMD) and biomechanical strength were detected.Results Compared with the sham group,the ovariectomized group had significantly reduced bone mineral density,elevated ALP level and serum calcium,phosphorus content had no significant change.After treatment witn alendronate and simvastatin for 8 weeks,calcium,phosphorus content had no significant change;alkaline phosphatase level decreased;femoral bone mineral density and biomechanical strength were improved.This result is more obvious in alendronate and simvastatin group, the difference was statistically significant.Conclusion Alendronate is beneficial to the restoration of biomechanical function in the osteoporosis fracture healing,and simvastatin can play a synergistic effect.%目的:通过实验观察阿仑膦酸钠联合辛伐他汀对骨质疏松大鼠骨折愈合的影

  11. The Problem of Absolute Knowledge. Metaphysics as Intellectual Intuition in Classic Modern European Philosophy

    Science.gov (United States)

    Torubarova, Tatyana V.

    2016-01-01

    Classic modern European philosophy explicate, reflect; leaving own history in fundamental metaphysical position, where the existence is understood as conscience. This position is representative in the process of historic development, transition of philosophical thought from R. Dekart to G. Hegel. It appears exactly the field of key metaphysical…

  12. New Grand Narratives: The Metaphysical Worldview of 'Avatar' and 'Cloud Atlas'

    NARCIS (Netherlands)

    J. Früchtl

    2016-01-01

    Referring to the films Avatar (2009) and Cloud Atlas (2012), the author will demonstrate that a new era of metaphysical holism follows Postmodernism. These films celebrate a resurrection of the flesh with 3-D technology and a reincarnation of souls with the aesthetic technique of morphing. However a

  13. Self-assembled monolayers of alendronate on Ti6Al4V alloy surfaces enhance osteogenesis in mesenchymal stem cells

    Science.gov (United States)

    Rojo, Luis; Gharibi, Borzo; McLister, Robert; Meenan, Brian J.; Deb, Sanjukta

    2016-07-01

    Phosphonates have emerged as an alternative for functionalization of titanium surfaces by the formation of homogeneous self-assembled monolayers (SAMs) via Ti-O-P linkages. This study presents results from an investigation of the modification of Ti6Al4V alloy by chemisorption of osseoinductive alendronate using a simple, effective and clean methodology. The modified surfaces showed a tailored topography and surface chemistry as determined by SEM microscopy and RAMAN spectroscopy. X-ray photoelectron spectroscopy revealed that an effective mode of bonding is created between the metal oxide surface and the phosphate residue of alendronate, leading to formation of homogenous drug distribution along the surface. In-vitro studies showed that alendronate SAMs induce differentiation of hMSC to a bone cell phenotype and promote bone formation on modified surfaces. Here we show that this novel method for the preparation of functional coatings on titanium-based medical devices provides osseoinductive bioactive molecules to promote enhanced integration at the site of implantation.

  14. Association Between Geranylgeranyl Pyrophosphate Synthase Gene Polymorphisms and Bone Phenotypes and Response to Alendronate Treatment in Chinese Osteoporotic Women△

    Institute of Scientific and Technical Information of China (English)

    Lan-wen Han; Mei Li; Dou-dou Ma; Xiao-jie Xu; Fang Lü; Yi Liu; Wei-bo Xia; Yan Jiang; Ou Wang; Xiao-ping Xing

    2016-01-01

    Objective To investigate the relationship between geranylgeranyl pyrophosphate synthase (GGPPS) genepolymorphisms and bone response to alendronate in Chinese osteoporotic women. Methods A total of 639 postmenopausal women with osteoporosis or osteopenia were included and randomly received treatment of low dose (70 mg per two weeks) or standard dose (70 mg weekly) of alendronate for one year. The six tag single nucleotide polymorphisms ofGGPPSgenewere identified. Bone mineral density (BMD), serum cross-linked C-telopeptide of type I collagen (β-CTX), and total alkaline phosphatase (ALP) were measured before and after treatment.GGPPS gene polymorphisms and the changes of BMD and bone turnover markers after treatment were analyzed. Results rs10925503 polymorphism ofGGPPS gene was correlated to serumβ-CTX levels at baseline, and patients with TT genotype had significantly higher serumβ-CTX level than those with TC or CC genotype (allP0.05). However,GGPPSgene polymorphisms were uncorrelated to percentage changes of BMD, serum total ALP, andβ-CTX levels (allP>0.05). ConclusionGGPPS gene polymorphisms are correlated to osteoclasts activity, but all tag single nucleotide polymorphisms ofGGPPS gene have no influence on the skeletal response to alendronate treatment.

  15. Bone formation induced by strontium modified calcium phosphate cement in critical-size metaphyseal fracture defects in ovariectomized rats.

    Science.gov (United States)

    Thormann, Ulrich; Ray, Seemun; Sommer, Ursula; Elkhassawna, Thaqif; Rehling, Tanja; Hundgeburth, Marvin; Henß, Anja; Rohnke, Marcus; Janek, Jürgen; Lips, Katrin S; Heiss, Christian; Schlewitz, Gudrun; Szalay, Gabor; Schumacher, Matthias; Gelinsky, Michael; Schnettler, Reinhard; Alt, Volker

    2013-11-01

    The first objective was to investigate new bone formation in a critical-size metaphyseal defect in the femur of ovariectomized rats filled with a strontium modified calcium phosphate cement (SrCPC) compared to calcium phosphate cement (CPC) and empty defects. Second, detection of strontium release from the materials as well as calcium and collagen mass distribution in the fracture defect should be targeted by time of flight secondary ion mass spectrometry (TOF-SIMS). 45 female Sprague-Dawley rats were randomly assigned to three different treatment groups: (1) SrCPC (n = 15), (2) CPC (n = 15), and (3) empty defect (n = 15). Bilateral ovariectomy was performed and three months after multi-deficient diet, the left femur of all animals underwent a 4 mm wedge-shaped metaphyseal osteotomy that was internally fixed with a T-shaped plate. The defect was then either filled with SrCPC or CPC or was left empty. After 6 weeks, histomorphometric analysis showed a statistically significant increase in bone formation of SrCPC compared to CPC (p = 0.005) and the empty defect (p = 0.002) in the former fracture defect zone. Furthermore, there was a statistically significant higher bone formation at the tissue-implant interface in the SrCPC group compared to the CPC group (p < 0.0001). These data were confirmed by immunohistochemistry revealing an increase in bone-morphogenic protein 2, osteocalcin and osteoprotegerin expression and a statistically significant higher gene expression of alkaline phosphatase, collagen10a1 and osteocalcin in the SrCPC group compared to CPC. TOF-SIMS analysis showed a high release of Sr from the SrCPC into the interface region in this area compared to CPC suggesting that improved bone formation is attributable to the released Sr from the SrCPC.

  16. A new experimental model to study healing process of metaphyseal fracture

    Institute of Scientific and Technical Information of China (English)

    HAN Na; ZHANG Pei-xun; WANG Wei-bin; HAN Da-cheng; CHEN Jian-hai; ZHAN Hong-bo; JIANG Bao-guo

    2012-01-01

    Background There are few researches for the healing of metaphyseal fractures; moreover,the animal models to study the metaphyseal fractures are usually made by the oscillating saw osteotomy without reliable fixation,which is not in accordance with our current clinical practice.In this study,we established a new model to observe the healing process of metaphyseal fractures.Methods Eighteen New Zealand rabbits were used in the study.The fracture model was created by splitting the medial tibial plateau in rabbits,then reset,and fixed with compression screws.At 1,2,3,4,6,and 8 weeks postoperatively,the tibial specimens were collected; firstly,a general observation and an X-ray examination of the specimens was done,and then they were embedded in methylmethacrylate and cut into sections with hard tissue slicer.The sections were stained with Giemsa reagent and examined under light microscopy.Results There was no fracture displacement in the tibial specimens of all time points,except for one showing a collapse.No external callus formation could be observed by X-ray and general examination.After 1 week of the operation,the fracture gap was filled by mesenchymal tissue; 2 weeks postoperatively,a large number of woven bones were formed; from the third week onwards,the woven bone began to turn into lamellar bone,and new trabecular structure began to form.In all of the slices,no obvious chondrocytes formed in fracture areas; thus,there was no endochondral ossification.Conclusions This model was an ideal fracture animal model and suitable for the study of metaphyseal fracture healing.The X-ray and histological images demonstrated that metaphyseal fracture healing was a process of direct bone healing through intramembranous bone formation under the conditions of minor trauma,good reduction,and firm fixation.

  17. Montage, Militancy, Metaphysics: Chris Marker and André Bazin

    Directory of Open Access Journals (Sweden)

    Sarah Cooper

    2010-01-01

    Full Text Available

     

    Abstract (E: This article focuses on the relationship between the work of André Bazin and Chris Marker from the late 1940s through to the late 1950s and beyond. The division between Bazin's ŘRight Bankř affiliation with Les Cahiers du Cinéma on the one hand, and Markerřs ŘLeft Bankř allegiances on the other, is called into question here as my argument seeks to muddy the waters of their conventional ideological separation across the river Seine. Working alliteratively through Markerřs well-known talent for deft montage along with his militancy, I consider Bazinřs praise for Markerřs editing technique Ŕ in spite of famously expressing a preference elsewhere for the long take, and deep focus cinematography Ŕ and I address their political differences and convergences. Yet I also explore the rather more unexpected question of metaphysics in order to further emphasize a closer relationship between these two figures. I chart the emergence of an enduring spiritual bond between critic and filmmaker that surfaces first in Markerřs writings for the left-wing Catholic journal L’EspritLocal treatment of osteoporosis with alendronate-loaded calcium phosphate cement

    Institute of Scientific and Technical Information of China (English)

    Zhao Jindong; Tang Hai; Wang Jiayang; Li Gang

    2014-01-01

    Background A new treatment strategy is to target specific areas of the skeletal system that are prone to clinically significant osteoporotic fractures.We term this strategy as the "local treatment of osteoporosis".The study was performed to investigate the effect of alendronate-loaded calcium phosphate cement (CPC) as a novel drug delivery system for local treatment of osteoorosis.Methods An in vitro study was performed using CPC fabricated with different concentrations of alendronate (ALE,0,2,5,10 weight percent (wt%)).The microstructure,setting time,infrared spectrum,biomechanics,drug release,and biocompatibility of the composite were measured in order to detect changes when mixing CPC with ALE.An in vivo study was also performed using 30 Sprague-Dawley rats randomly divided into six groups:normal,Sham (ovariectomized (OVX) + Sham),CPC with 2% ALE,5%ALE,and 10% ALE groups.At 4 months after the implantation of the composite,animals were sacrificed and the caudal vertebrae (levels 4-7) were harvested for micro-CT examination and biomechanical testing.Results The setting time and strength of CPC was significantly faster and greater than the other groups.The ALE release was sustained over 21 days,and the composite showed good biocompatibility.In micro-CT analysis,compared with the Sham group,there was a significant increase with regard to volumetric bone mineral density (BMD) and trabecular number (Tb.N) in the treated groups (P <0.05).Trabecular spacing (Tb.Sp) showed a significant increase in the Sham group compared to other groups (P <0.01).However,trabecular thickness (Tb.Th) showed no significant difference among the groups.In biomechanical testing,the maximum compression strength and stiffness of trabecular bone in the Sham group were lower than those in the experimental groups.Conclusions The ALE-loaded CPC displayed satisfactory properties in vitro,which can reverse the OVX rat vertebral trabecular bone microarchitecture and biomechanical

  18. Effects of alendronate and strontium ranelate on cancellous and cortical bone mass in glucocorticoid-treated adult rats.

    Science.gov (United States)

    Sun, P; Cai, D H; Li, Q N; Chen, H; Deng, W M; He, L; Yang, L

    2010-06-01

    We studied the effects of alendronate (Aln) and strontium ranelate (SrR) administration on cancellous and cortical bone in glucocorticoid (GC)-treated rats. Thirty-two 3.5-month male Sprague-Dawley rats were randomized into four groups: age-matched normal control (Nrm), methylprednisolone (Met; 5.0 mg/kg/day, sc, for 5 days/week), Met plus Aln orally (1.0 mg/kg/day), and Met plus SrR orally (900 mg/kg/day). The study period was 9 weeks. DXA was used to evaluate the femoral diaphysis and fifth lumbar vertebra (L5). Histomorphometry was performed in the proximal tibial metaphysis and tibial diaphysis. Met significantly decreased body weight and bone mineral density (BMD) compared with Nrm. Aln and SrR significantly increased body weight and BMD compared with Met. SrR resulted in significantly higher BMD than Aln. Met markedly decreased BV/TV, Tb.Th, and Tb.N and increased Tb.Sp compared with Nrm. Aln and SrR showed significantly increased of BV/TV, Tb.Th, and Tb.N and improved bone architecture. Moreover, Met reduced %Ct.Ar, enlarged %Ma.Ar, and decreased bone formation indices in the periosteum as well as increased ES/BS in the endosteum compared with Nrm. Aln significantly decreased endosteal ES/BS compared with Met. SrR significantly increased %Ct.Ar and bone formation indices in the periosteum as well as the endosteum and decreased endosteal ES/BS compared with Met. Furthermore, SrR led to a significantly higher cancellous and endocortical MS/BS and endocortical bone formation compared with Aln. Our findings suggest SrR at a dose of 900 mg/kg has a greater effect than Aln at 1.0 mg/kg, according to BMD and histomorphometric analysis, in preventing GC-induced osteopenia. Therefore, SrR might be applicable as a bone therapeutic agent to treat secondary osteoporosis in the clinic. PMID:20390406

  19. A novel PHBV/HA microsphere releasing system loaded with alendronate

    International Nuclear Information System (INIS)

    Microspheres of poly(β-hydroxybutyrate-co-β-hydroxyvalerate) (PHBV) incorporated with hydroxyapatite (HA) and loaded with alendronate (AL), an osteoporosis preventing drugs, were prepared by single emulsion technique. Several methods were used to evaluate this novel drug carrier microsphere system (referred as PHBV/HA-AL). Fourier transform infrared (FTIR) was used to evaluate the enwrapping of HA and the X-ray diffraction (XRD) analysis further confirmed the success. The morphology of PHBV/HA-AL microspheres was observed by scanning electron microscope (SEM), showing rough surface with HA particles enwrapped in the PHBV matrix. The in vitro drug releasing profile of PHBV/HA-AL system was investigated in a 26-day period. There is a sustained releasing pattern after a slight burst release during the first few days. Additionally, rabbit mesenchymal stem cells (MSCs) were used to evaluate the cytotoxicity of the PHBV/HA-AL composites. This controlled release system can well support the proliferation of MSCs. The novel PHBV/HA-AL controlled release system is promising for bone repair therapy.

  1. A novel PHBV/HA microsphere releasing system loaded with alendronate

    Energy Technology Data Exchange (ETDEWEB)

    Huang Wei [School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China); Key Laboratory of Special Functional Materials, South China University of Technology, Ministry of Education, Guangzhou 510641 (China); Wang Yingjun, E-mail: imwangyj@scut.edu.cn [School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China); Key Laboratory of Special Functional Materials, South China University of Technology, Ministry of Education, Guangzhou 510641 (China); Ren Li; Du Chang; Shi Xuetao [School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China); Key Laboratory of Special Functional Materials, South China University of Technology, Ministry of Education, Guangzhou 510641 (China)

    2009-08-31

    Microspheres of poly({beta}-hydroxybutyrate-co-{beta}-hydroxyvalerate) (PHBV) incorporated with hydroxyapatite (HA) and loaded with alendronate (AL), an osteoporosis preventing drugs, were prepared by single emulsion technique. Several methods were used to evaluate this novel drug carrier microsphere system (referred as PHBV/HA-AL). Fourier transform infrared (FTIR) was used to evaluate the enwrapping of HA and the X-ray diffraction (XRD) analysis further confirmed the success. The morphology of PHBV/HA-AL microspheres was observed by scanning electron microscope (SEM), showing rough surface with HA particles enwrapped in the PHBV matrix. The in vitro drug releasing profile of PHBV/HA-AL system was investigated in a 26-day period. There is a sustained releasing pattern after a slight burst release during the first few days. Additionally, rabbit mesenchymal stem cells (MSCs) were used to evaluate the cytotoxicity of the PHBV/HA-AL composites. This controlled release system can well support the proliferation of MSCs. The novel PHBV/HA-AL controlled release system is promising for bone repair therapy.

  2. Prolegomena to any future metaphysics that will be able to come forward as science the Paul Carus translation

    CERN Document Server

    Kant, Immanuel

    1977-01-01

    Kant’s Prolegomena -- its full title, in the eighteenth-century manner, is Prolegomena to Any Future Metaphysics Which Will Be Able to Come Forth as Science -- is a classic in metaphysics and the theory of knowledge. It deals with the perennially baffling questions: How do we know? How much can we know? Its answers to these questions are interesting especially now. We live in one of the recurring periods of intellectual and cultural history that are skeptical and impatient of systems of speculative metaphysics, and a distrust of speculation is the leading motif of the Prolegomena. Though Kant's arguments against speculative metaphysics differ from those of our contemporaries, in some of his results he anticipates their negative conclusions. The Prolegomena, however, is not interesting merely as an historical anticipation of recent views; indeed, as such it has been as it were condemned in advance by Kant (Prolegomena, Introduction). Rather, its chief interest to the student of philosophy is probably the way...

  3. Purpose in the Universe the moral and metaphysical case for ananthropocentric purposivism

    CERN Document Server

    Mulgan, Tim

    2015-01-01

    Two familiar worldviews dominate Western philosophy: materialist atheism and the benevolent God of the Abrahamic faiths. Tim Mulgan explores a third way. Ananthropocentric Purposivism claims that there is a cosmic purpose, but human beings are irrelevant to it. Purpose in the Universe develops a philosophical case for Ananthropocentric Purposivism that it is at least as strong as the case for either theism or atheism. The book borrows traditional theist arguments to defend a cosmic purpose. These include cosmological, teleological, ontological, meta-ethical, and mystical arguments. It then borrows traditional atheist arguments to reject a human-centred purpose. These include arguments based on evil, diversity, and the scale of the universe. Mulgan also highlights connections between morality and metaphysics, arguing that evaluative premises play a crucial and underappreciated role in metaphysical debates about the existence of God, and Ananthropocentric Purposivism mutually supports an austere consequentialis...

  4. Production, quality control, biodistribution assessment and preliminary dose evaluation of {sup 166}Ho-alendronate as a bone marrow ablative agent

    Energy Technology Data Exchange (ETDEWEB)

    Fakhari, Ashraf [Tehran University of Medical Sciences (Iran, Islamic Republic of). Dept. of Radiopharmacy; Jalilian, Amir Reza; Yousefnia, Hassan; Zolghadri, Samaneh; Samani, Ali Bahrami; Akbari, Mahmoud Reza; Deha, Fariba Johari [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Shafiee-Ardestani, Mahdi; Khalaj, Ali [Tehran University of Medical Sciences (Iran, Islamic Republic of). Dept. of Medicinal Chemistry

    2015-07-01

    In this study, production, quality control and biodistribution studies of {sup 166}Ho-alendronate have been presented and followed by dosimetric evaluation for human based on biodistribution data in wild-type rats. {sup 166}Ho chloride was obtained by thermal neutron irradiation of natural {sup 165}Ho(NO{sub 3}){sub 3} samples. {sup 166}Ho-alendronate complex was prepared by adding the desired amount of alkaline alendronate solution (0.2 mL, 150 mg/mL) to 3-5 mCi of the {sup 166}HoCl{sub 3} solution. Radiochemical purity of the complex was monitored by instant thin layer chromatography (ITLC). {sup 166}Ho-alendronate complex was prepared in high radiochemical purity (> 99%, ITLC) and specific activity of 4.4 GBq/mmol. Stability studies of the complex in the final preparation and in the presence of human serum were performed up to 48 h. The major accumulation of the radio-complex was in the bone tissues followed by absorbed dose evaluation of each human organ by RADAR software used for modelling the radiation dose delivered. The final preparation was administered to wild-type rats and biodistribution of the complex was performed 2-48 h post injection showing major accumulation of the complex in the bone tissue. The highest absorbed dose for {sup 166}Ho-alendronate is observed in bone surface and red marrow with 2.670 and 1.880 mSv/MBq; respectively. These findings suggest that {sup 166}Ho-alendronate has considerable characteristics compared to {sup 166}Ho-DOTMP and can be a possible candidate for bone marrow ablation in patients with multiple myeloma.

  5. Does Alendronate reduce the risk of fracture in men? A meta-analysis incorporating prior knowledge of anti-fracture efficacy in women

    Directory of Open Access Journals (Sweden)

    Papaioannou Alexandra

    2005-07-01

    Full Text Available Abstract Background Alendronate has been found to reduce the risk of fractures in postmenopausal women as demonstrated in multiple randomized controlled trials enrolling thousands of women. Yet there is a paucity of such randomized controlled trials in osteoporotic men. Our objective was to systematically review the anti-fracture efficacy of alendronate in men with low bone mass or with a history of prevalent fracture(s and incorporate prior knowledge of alendronate efficacy in women in the analysis. Methods We examined randomized controlled trials in men comparing the anti-fracture efficacy of alendronate to placebo or calcium or vitamin D, or any combination of these. Studies of men with secondary causes of osteoporosis other than hypogonadism were excluded. We searched the following electronic databases (without language restrictions for potentially relevant citations: Medline, Medline in Process (1966-May 24/2004, and Embase (1996–2004. We also contacted the manufacturer of the drug in search of other relevant trials. Two reviewers independently identified two trials (including 375 men, which met all inclusion criteria. Data were abstracted by one reviewer and checked by another. Results of the male trials were pooled using Bayesian random effects models, incorporating prior information of anti-fracture efficacy from meta-analyses of women. Results The odds ratios of incident fractures in men (with 95% credibility intervals with alendronate (10 mg daily were: vertebral fractures, 0.44 (0.23, 0.83 and non-vertebral fractures, 0.60 (0.29, 1.44. Conclusion In conclusion, alendronate decreases the risk of vertebral fractures in men at risk. There is currently insufficient evidence of a statistically significant reduction of non-vertebral fractures, but the paucity of trials in men limit the statistical power to detect such an effect.

  6. ALEXANDER OF APHRODISIAS’ THE VIEWS BELONGING TO THE METAPHYSICS IN THE CONTEXT OF ARISTOTLE AND ISLAMIC PHILOSOPHERS

    OpenAIRE

    Sarıtaş, Kamil

    2012-01-01

    Alexander of Aphrodisias is a philosopher and commentator who is a member of Aristotelian school. In the history of philosophy Alexander who is first commentator taking up in detail of Peripatetism was admitted greatly influenced Islamic philosophers as well. In this article it was intended to be adressing the views of metaphysics of Alexander of Aphrodisias. His thoughts related Metaphysics such being, God, mind and immortality were included. However, by being compared Alexander's ideas ...

  7. Crititics to Metaphysics by Modern Philosophers (Discourse on Human Beings in Reality)

    OpenAIRE

    Frederikus Fios

    2016-01-01

    We have entered the 21st century that is popularly known as the era of the development of modern science and technology. Philosophy provides naming for contemporary era as postmodern era. But do we suddenly come to this day and age? No! Because humans are homo viator, persona that does pilgrimage in history, space and time. Philosophy has expanded periodically in the long course of history. Since the days of classical antiquity, philosophy comes with a patterned metaphysical paradigm. T...

  8. Metaphysics of infinity the problem of motion and the infinite brain

    CERN Document Server

    Soteropoulos, Ion

    2013-01-01

    A work of impressive and original scholarship, Metaphysics of Infinity: The Problem of Motion and the Infinite Brain is an informed and informative study that is especially recommended to the attention of anyone with in interest in the logical mechanics of the physical universe, the capacity of the human brain, and integrated role of robots and artificial intelligence in the future. An understanding of elementary mathematical equations is required to fully appreciate the principles upon which Ion Soteropoulos has founded her pr

  9. Descriptive Metaphysics, Natural Language Metaphysics, Sapir-Whorf, and All That Stuff: Evidence from the Mass-Count Distinction

    Directory of Open Access Journals (Sweden)

    Francis Jeffry Pelletier

    2010-12-01

    . Language 5: 207–214. Reprinted in David Mandelbaum (ed., Selected Writings of Edward Sapir in Language Culture and Personality, 160-166 (Berkeley and Los Angeles: University of California Press, 1968.Schank, Roger. 1972. ‘Conceptual Dependency: A Theory of Natural Language Understanding’. Cognitive Psychology 3: 552–631.http://dx.doi.org/10.1016/0010-0285(7290022-9Sharvy, Richard. 1978. ‘Maybe English has No Count Nouns: Notes on Chinese Semantics’. Studies in Language 2: 345–365.http://dx.doi.org/10.1075/sl.2.3.04shaStrawson, Peter. 1959. Individuals: An Essay in Descriptive Metaphysics. London: Methuen.Strawson, Peter. 1966. The Bounds of Sense. London: Methuen.Vendler, Zeno. 1967. Linguistics in Philosophy. Ithaca, NY: Cornell Univ. Press. Chapter 5. “Nouns and Nominalizations”.Vendler, Zeno. 1972. Res Cogitans. Ithaca, NY: Cornell Univ. Press. Chapter 5. “On What One Knows”.Whorf, Benjamin. 1940a. ‘Linguistics as an Exact Science’. Technology Review 43: 61–63, 80–83. Reprinted in (Whorf 1956, 220–232.Whorf, Benjamin. 1940b. ‘Science and Linguistics’. Technology Review 42: 229–231,247–248. Reprinted in (Whorf 1956, 207–219.Whorf, Benjamin. 1941. ‘The Relation of Habitual Thought and Behavior to Language’. In L. Spier (ed. ‘Language, Culture, and Personality: Essays in Memory of Edward Sapir’, 75–93. Menasha, WI: Sapir Memorial Publication Fund. Reprinted in (Whorf 1956, 134–159.Whorf, Benjamin. 1956. Language, Thought and Reality. Cambridge UP: MIT Press. Edited by J. Carroll.Wierzbicka, Anna. 1988a. ‘Oats and Wheat: Mass Nouns, Iconicity, and Human Categorization’. In Anna Wierzbicka (ed. ‘The Semantics of Grammar’, 499–560. Amsterdam: John Benjamins.Wierzbicka, Anna. 1988b. The Semantics of Grammar. Amsterdam: John Benjamins.Wierzbicka, Anna. 1994. ‘Opening Statement’. In ‘Semantic and Lexical Universals’, 1–3. Philadelphia: J. Benjamins.Wierzbicka, Anna. 1996. Semantics: Primes and Universals

  10. Osteosclerotic metaphyseal dysplasia: a skeletal dysplasia that may mimic lead poisoning in a child with hypotonia and seizures

    International Nuclear Information System (INIS)

    We report the case of a 23-month-old male with hypotonia, developmental delay, and complex seizures. Radiographs revealed profound sclerosis of the metaphyses and epiphyses of the long and short bones in the extremities, with a unique pattern of distribution. Sclerosis also involved the anterior ribs, iliac crests, talus, and calcaneus. The skull and vertebral bodies appeared unaffected. Blood lead levels were normal. We believe that this constellation of clinical and radiographic abnormalities closely resembles osteosclerotic metaphyseal dysplasia (OMD) due to an autosomal recessive defect. Characteristic skeletal findings were instrumental in determining the diagnosis. OMD is a very rare sclerosing bone disorder, first described in 1993. The syndrome is characterized clinically by developmental delay of a progressive nature, hypotonia, elevated alkaline phosphatase, and late-onset spastic paraplegia. We encountered a young child with these neurologic symptoms who displayed sclerotic metaphyseal changes on hand radiographs obtained to determine the bone age. Lead poisoning, a known cause of metaphyseal sclerosis, was initially suspected. Careful analysis of the metaphyseal bone changes helped to distinguish this bone dysplasia from lead poisoning and other causes of metaphyseal sclerosis. (orig.)

  11. Truth, Art, and the “New Sensuousness”: Understanding Heidegger’s Metaphysical Reading of Nietzsche

    Directory of Open Access Journals (Sweden)

    James Magrini

    2009-06-01

    Full Text Available In the first of four lectures on Nietzsche’s philosophy, “The Will to Poweras Art” (1936-37, Heidegger argues that the unique and importantrelationship between truth and art, which Nietzsche suggests, must beunderstood “with a view to the conquest of nihilism,” i.e., within the historical context of a radically novel interpretation of sensuous reality. Beginning with the project of overturning Platonism as the active countermovement to nihilism, this essay interprets Heidegger’s difficult notion of the discordant relationship between truth (the fixation of semblance and art (the transfiguration of semblance in Nietzsche’s philosophy, emphasizing the supreme importance of art as life’s greatest enhancing force. The analysis is conducted within the context of Nietzsche’s metaphysics as presented by Heidegger, who claims thatas a metaphysical thinker, Nietzsche could not explain such topics as “truth,” “Being,” and “Becoming” in terms beyond the conceptualization of Western philosophy. In spite of that, his thought intimates a movement beyond the constraints of the tradition within which he was entrenched. In addition to providing a detailed exegesis of Heidegger’s lecture course, the problems associated with Heidegger’s metaphysical interpretation of Nietzsche’s philosophy will be discussed, problems that commentators such as Alan Schrift (Nietzsche and the Question of Interpretation believe stem from Heidegger’s stringent and restrictive methodological choices for approaching the reading of Nietzsche.

  12. Cancellous Screws Are Biomechanically Superior to Cortical Screws in Metaphyseal Bone.

    Science.gov (United States)

    Wang, Tim; Boone, Christopher; Behn, Anthony W; Ledesma, Justin B; Bishop, Julius A

    2016-09-01

    Cancellous screws are designed to optimize fixation in metaphyseal bone environments; however, certain clinical situations may require the substitution of cortical screws for use in cancellous bone, such as anatomic constraints, fragment size, or available instrumentation. This study compares the biomechanical properties of commercially available cortical and cancellous screw designs in a synthetic model representing various bone densities. Commercially available, fully threaded, 4.0-mm outer-diameter cortical and cancellous screws were tested in terms of pullout strength and maximum insertion torque in standard-density and osteoporotic cancellous bone models. Pullout strength and maximum insertion torque were both found to be greater for cancellous screws than cortical screws in all synthetic densities tested. The magnitude of difference in pullout strength between cortical and cancellous screws increased with decreasing synthetic bone density. Screw displacement prior to failure and total energy absorbed during pullout strength testing were also significantly greater for cancellous screws in osteoporotic models. Stiffness was greater for cancellous screws in standard and osteoporotic models. Cancellous screws have biomechanical advantages over cortical screws when used in metaphyseal bone, implying the ability to both achieve greater compression and resist displacement at the screw-plate interface. Surgeons should preferentially use cancellous over cortical screws in metaphyseal environments where cortical bone is insufficient for fixation. [Orthopedics.2016; 39(5):e828-e832.].

  13. Effects of short-term alendronate treatment on the three-dimensional microstructural, physical and mechanical properties of dog trabecular bone

    DEFF Research Database (Denmark)

    Hu, J; Ding, Ming; Søballe, K;

    2002-01-01

    proximal humeri. These specimens were scanned using a high-resolution microcomputed tomography (micro-CT) system. From accurate data sets, three-dimensional microstructural properties were calculated and physical and mechanical properties were determined. Treatment with alendronate increased bone volume...... in mechanical properties in the humeral head trabecular bone were similar to those seen in the lumbar vertebrae. Our results demonstrate that alendronate increases the mechanical properties of healthy canine trabecular bone after short-term treatment. The physical and microstructural changes of trabecular bone...... are consistent with the significantly increased mechanical properties....

  14. Alendronato de sódio: metodologias para análise quantitativa Sodium alendronate: methods for analytical quantitation

    Directory of Open Access Journals (Sweden)

    Ana Ferreira Ribeiro

    2005-10-01

    Full Text Available This paper presents a review of some published proposals for the analysis of sodium alendronate. The drug is an aminobisphosphonate compound used to inhibit the osteoclastic resorption of bone, and different methods were developed for its quantitative determination. These methodologies employed reversed-phase or ion-exchange HPLC analysis, both associated with different detectors: UV and fluorescence detection after derivatization of the drug, conductivity and refractive index detectors, as well as the indirect UV detection. Titrimetry and spectrophotometry (with previous complexation of the drug, which are simpler procedures, were also described, but they showed poor specificity when compared to liquid chromatography.

  15. Long-term effects of alendronate on fracture healing and bone remodeling of femoral shaft in ovariectomized rats

    OpenAIRE

    Fu, Ling-jie; Tang, Ting-ting; Hao, Yong-qiang; Dai, Ke-Rong

    2013-01-01

    Aim: To investigate the long-term effects of alendronate (Aln), a widely used oral bisphosphonate, on fracture healing and bone remodeling in ovariectomized rats. Methods: Adult female SD rats underwent ovariectomy, and then bilateral femoral osteotomy at 12 weeks post-ovariectomy. From d 2 post-ovariectomy, the animals were divided into 3 groups, and treated with Aln (3 mg·kg−1·d−1, po) for 28 weeks (Aln/Aln), Aln for 12 weeks and saline for 16 weeks (Aln/Saline) or saline for 28 weeks (Sali...

  16. Characterization of alendronate sodium-loaded UHMWPE for anti-osteolysis in orthopedic applications

    Energy Technology Data Exchange (ETDEWEB)

    Yang Dan [Key Lab of Advanced Technologies of Materials, Ministry of Education, Tribology Research Institute, School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031 (China); Qu Shuxin, E-mail: qushuxin@swjtu.edu.cn [Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031 (China); Huang Jie [Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031 (China); Cai Zhenbing; Zhou Zhongrong [Key Lab of Advanced Technologies of Materials, Ministry of Education, Tribology Research Institute, School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031 (China)

    2012-02-01

    Ultra-high molecule weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), a potential drug to prevent debris-induced osteolysis, was developed in our previous study. This study aims to investigate the wear performance of UHMWPE-ALNs. In this study, wear test, mechanical test, differential scanning calorimetry (DSC) and contact angle test were applied to characterize the wear performance, mechanical behavior and physical properties of UHMWPE-ALNs. The effect of ALN on the wear performance of UHMWPE-ALNs was investigated by scanning electron microscope (SEM), back scattering electrons (BSE) and energy dispersive X-ray spectrum (EDX). The results of wear test showed that the friction coefficient and volumetric loss of UHMWPE-ALN 0.5 wt.% were comparable with those of UHMWPE. The result of SEM-BSE-EDX revealed that the wear debris detached easily from the ALN-agglomerated regions, which was mainly responsible for the decrease of wear resistance of UHMWPE-ALN 1.0 wt.%. The loaded ALN resulted in the increase of hydrophilicity of UHMWPE-ALNs. The decrease of toughness and crystallinity of UHMWPE-ALN 1.0 wt.% attributed to the non-uniform distribution of ALN. The UHMWPE-ALN 0.5 wt.%, in which no ALN agglomeration was observed, possessed approving mechanical properties and wear performance, might have potential clinical application to prevent the debris-induced osteolysis in prosthetic joints. - Highlights: Black-Right-Pointing-Pointer The wear resistance, mechanical and physical properties UHMWPE-ALN 0.5 wt.% are not significantly different with those of UHMWPE. Black-Right-Pointing-Pointer The hydrophilicity of UHMWPE increased after loaded ALN. Black-Right-Pointing-Pointer The decrease of wear performance of UHMWPE-ALN 1.0 wt.% attributed to the non uniform distribution of ALN. Black-Right-Pointing-Pointer The ALN-agglomerated region of UHMWPE-ALN 1.0 wt.% was most easily worn out during wear processing.

  17. Reciprocating sliding wear behavior of alendronate sodium-loaded UHMWPE under different tribological conditions.

    Science.gov (United States)

    Huang, Jie; Qu, Shuxin; Wang, Jing; Yang, Dan; Duan, Ke; Weng, Jie

    2013-07-01

    The aim of this study is to investigate the tribological behaviors and wear mechanisms of ultra-high molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), a potential drug to treat osteolysis, under different normal loads and lubrication conditions. A mixture of UHMWPE powder and ALN (1.0 wt.%) solution was dried and hot pressed. The static and dynamic friction coefficients of UHMWPE-ALN were slightly higher than those of UHMWPE except under normal load as 10 N and in 25 v/v % calf serum. The specific wear rates of UHMWPE-ALN and UHMWPE were the lowest in 25 v/v % calf serum compared to those in deionized water or physiological saline. In particular, the specific wear rate of UHMWPE-ALN was lower than that of UHMWPE at 50 N in 25 v/v % calf serum. The main wear mechanisms of UHMWPE and UHMWPE-ALN in deionized water and UHMWPE in physiological saline were abrasive. The main wear mechanism of UHMWPE-ALN in physiological saline was micro-fatigue. In 25 v/v % calf serum, the main wear mechanism of UHMWPE and UHMWPE-ALN was abrasive wear accompanied with plastic deformation. The results of Micro-XRD indicated that the molecular deformation of UHMWPE-ALN and UHMWPE under the lower stress were in the amorphous region but in the crystalline region at the higher stress. These results showed that the wear of UHMWPE-ALN would be reduced under calf serum lubricated, which would be potentially applied to treat osteolysis.

  18. The determination of apoptosis rates on articular cartilages of ovariectomized rats with and without alendronate treatment.

    Science.gov (United States)

    Acar, Nuray; Balkarli, Huseyin; Soyuncu, Yetkin; Ozbey, Ozlem; Celik-Ozenci, Ciler; Korkusuz, Petek; Ustunel, Ismail

    2016-06-01

    Osteoporosis (OP) is a major health problem characterized by compromised bone strength. Osteoarthritis (OA) is a joint disease that progresses slowly and is characterized by breakdown of the cartilage matrix. Alendronate (ALN), a nitrogen-containing bisphosphonate (BIS), inhibits bone loss and increases bone mineralization, and has been used clinically for the treatment of OP. It is still controversial whether BIS is effective in inhibiting the progression of OA. Chondrocyte apoptosis has been described in both human and experimentally induced OA models. In our study we aimed to detect whether ALN could protect articular cartilage from degeneration and reduce apoptosis rates in experimentally OA induced rats. For this rats were ovariectomized (ovex), nine weeks after operation rats were injected 30 µg/kg/week ALN subcutaneously for six weeks. After six weeks articular cartilages were obtained. We did Safranin O staining and Mankin and Pritzker scorings to evaluate degeneration and investigated the expressions of p53, cleaved caspase 3, Poly ADP-ribose (PAR), Poly ADP-ribose polymerase 1 (PARP 1), and applied TUNEL technique to determine apoptotis rates. We found a significant decrease in glycosaminoglycan (GAG) amount and increased apoptosis which indicates damage on articular cartilages of ovex rats. GAG amount was higher and apoptosis rate was lower on articular cartilages of ALN treated ovex rats compared to the ovex group. In contrary to studies showing that early ALN treatment has a protective effect, our study shows late ALN treatment has a chondroprotective effect on articular cartilage since we treated rats nine weeks after ovariectomy. PMID:26631351

  19. In vitro incorporation studies of 99mTc-alendronate sodium at different bone cell lines

    International Nuclear Information System (INIS)

    Bisphosphonates can be labeled with Technetium-99m (99mTc) and are used for bone imaging because of their good localization in the skeleton and rapid clearance from soft tissues. Over the last decades bone scintigraphy has been used extensively in the evaluation of oncological patients to provide information about the sites of bone lesions, their prognosis and the effectiveness of therapy by showing the sequential changes in tracer uptake. Since the lesion visualization and lesion/bone ratio are important utilities for a bone scanning radiopharmaceutic; in this study incorporation of 99mTc labeled alendronate sodium (99mTc-ALD) was evaluated in U2OS (human bone osteosarcoma) and NCI-H209 (human bone carcinoma) cell lines. ALD was directly labeled by 99mTc, radiochemical purity and stability of the complex were analyzed by radioactive thin layer chromatography and radioactive high performance liquid chromatography studies. For cell incorporation study, NCI-H209 and U2OS cell lines were used with standard cell culture methods. The six well plates were used for all experiments and the integrity of each cell monolayer was checked by measuring its transepithelial electrical resistance (TEER) with an epithelial voltammeter. Results confirmed that ALD was successfully radiolabeled with 99mTc. 99mTc-ALD incorporated with NCI-H209 and U2OS cells. The uptake percentages of 99mTc-ALD in NCI-H209 and U2OS cell lines were found significantly different. Since 99mTc-ALD highly uptake in cancer cell line, the results demonstrated that radiolabeled ALD may be a promising agent for bone cancer diagnosis. (author)

  20. The bone resorption inhibitors odanacatib and alendronate affect post-osteoclastic events differently in ovariectomized rabbits.

    Science.gov (United States)

    Jensen, Pia Rosgaard; Andersen, Thomas Levin; Pennypacker, Brenda L; Duong, Le T; Delaissé, Jean-Marie

    2014-02-01

    Odanacatib (ODN) is a bone resorption inhibitor which differs from standard antiresorptives by its ability to reduce bone resorption without decreasing bone formation. What is the reason for this difference? In contrast with other antiresorptives, such as alendronate (ALN), ODN targets only the very last step of the resorption process. We hypothesize that ODN may therefore modify the remodeling events immediately following osteoclastic resorption. These events belong to the reversal phase and include recruitment of osteoblasts, which is critical for connecting bone resorption to formation. We performed a histomorphometric study of trabecular remodeling in vertebrae of estrogen-deficient rabbits treated or not with ODN or ALN, a model where ODN, but not ALN, was previously shown to preserve bone formation. In line with our hypothesis, we found that ODN treatment compared to ALN results in a shorter reversal phase, faster initiation of osteoid deposition on the eroded surfaces, and higher osteoblast recruitment. The latter is reflected by higher densities of mature bone forming osteoblasts and an increased subpopulation of cuboidal osteoblasts. Furthermore, we found an increase in the interface between osteoclasts and surrounding osteoblast-lineage cells. This increase is expected to favor the osteoclast-osteoblast interactions required for bone formation. Regarding bone resorption itself, we show that ODN, but not ALN, treatment results in shallower resorption lacunae, a geometry favoring bone stiffness. We conclude that, compared to standard antiresorptives, ODN shows distinctive effects on resorption geometry and on reversal phase activities which positively affect osteoblast recruitment and may therefore favor bone formation. PMID:24085265

  1. Czy sądy metafizyczne mówią coś o świecie? Wittgensteinowskie źródła deflacjonizmu metafizycznego i jego modele [Do metaphysical judgments say something about the world or not? Wittgensteinian roots of deflationary metaphysics and its models

    Directory of Open Access Journals (Sweden)

    Sebastian Kolodziejczyk

    2014-09-01

    Full Text Available Many of contemporary philosophers argue against metaphysics putting forward a thesis that metaphysical claims are deflationary. This way of thinking seems to be not only persuasive but above all it rightly expresses a main difficulty of metaphysical inquires. In this paper I am trying to shed a little light on the problem of deflation of metaphysical judgments. In the first section I refer to some Wittgenstein's ideas from Tractatus logico-philosophicus and I focus on the phenomenon of manifestation as a possible source of deflation of metaphysics. The second section is devoted to the Wittgenstein's concepts of language games on the one hand and rules on the other; both of them are a key to understanding of the deepest dimensions of deflationary metaphysics. The third section is an elaboration of three models of deflation of metaphysical expressions: 1. deflation in regard to the informative status of metaphysical judgments; 2. deflation in regard to the metasemantic properties of judgments about the world, and 3. deflation in regard to the semantic ground of ontological judgments. The fourth and last part of the paper is an exposition of two crucial problems which metaphysics has to face with. I call the first of them 'a problem with conceptualization of the metaphysical experience', whereas the second one is labeled 'a problem with semantic inclusion of metaphysical expressions into judgments about facts'.

  2. Role of connexin 43 in the mechanism of action of alendronate: dissociation of anti-apoptotic and proliferative signaling pathways.

    Science.gov (United States)

    Lezcano, V; Bellido, T; Plotkin, L I; Boland, R; Morelli, S

    2012-02-15

    Bisphosphonates (BPs) inhibit osteocyte and osteoblast apoptosis via opening of connexin (Cx) 43 hemichannels and activating the extracellular signal regulated kinases ERKs. Previously, we hypothesized that intracellular survival signaling is initiated by interaction of BPs with Cx43. However, using whole cell binding assays with [(3)H]-alendronate, herein we demonstrated the presence of saturable, specific and high affinity binding sites in the Cx43-expressing ROS 17/2.8 osteoblastic cells, authentic osteoblasts and MLO-Y4 cells expressing Cx43 or not, as well as in HeLa cells lacking Cx43 expression and ROS 17/2.8 cells pretreated with agents that disassemble Cx channels. In addition, both BPs and the PTP inhibitor Na(3)VO(4) increased proliferation of cells expressing Cx43 or not. Furthermore, although BPs are internalized and inhibit intracellular enzymes in osteoclasts, whether the drugs penetrate non-resorptive bone cells is not known. To clarify this, we evaluated the osteoblastic uptake of AF-ALN, a fluorescently labeled analog of alendronate. AF-ALN was rapidly internalized in cells expressing Cx43 or not indicating that this process is not mediated via Cx43 hemichannels. Altogether, these findings suggest that although required for triggering intracellular survival signaling by BPs, Cx43 is dispensable for cellular BP binding, its uptake, as well as the proliferative effects of these agents. PMID:22230328

  3. The Reconstruction of Kant's Moral Metaphysics---On the Demarcation between Knowledge and Metaphysics%康德道德形而上学的重建--兼论知识与形而上学的划界

    Institute of Scientific and Technical Information of China (English)

    高新文; 黄逸超

    2015-01-01

    康德批判了莱布尼茨、沃尔夫以来的形而上学独断论,完成了知识与形而上学的划界。在其道德哲学中,为保证道德的纯洁性,康德努力寻求并建立形而上的基础。在分析了康德形而上学重建的思路基础上,论证了道德哲学中善良意志、绝对命令等基本概念的含义,简要阐述了康德道德形而上学的历史影响及价值。%Kant criticized the dogmatism of metaphysics since Leibniz and Wolff ,and completed the de‐marcation between knowledge and metaphysics .In the moral philosophy ,to ensure the purity of morali‐ty ,Kant's tried to seek and establish a metaphysical basis .This paper analyses the reconstruction of Kant's metaphysics thinking ,demonstrates the basic meanings ,as good will and absolute command , etc .in the moral philosophy ,and briefly expounds the historical influence and value of Kant's moral metaphysics .

  4. Three-year experience with combined treatment with alendronate and alfacalcidol in Japanese patients with severe bone loss and osteoporotic fracture

    Directory of Open Access Journals (Sweden)

    Iwamoto J

    2011-06-01

    Full Text Available Jun Iwamoto1, Yoshihiro Sato2, Mitsuyoshi Uzawa3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Neurology, Mitate Hospital, Fukuoka, Japan; 3Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, JapanPurpose: Combined treatment with alendronate and alfacalcidol is more useful to increase bone mineral density (BMD than alendronate or alfacalcidol alone. A retrospective study was conducted to investigate the 3-year outcome of combined treatment with alendronate and alfacalcidol in patients with severe bone loss (BMD ≤ 50% of the young adult mean and osteoporotic fracture.Methods: Thirty-four patients (six men and 28 postmenopausal women with primary or secondary osteoporosis who had been treated with alendronate and alfacalcidol for more than 3 years were analyzed. The lumbar spine or total hip BMD and bone turnover markers were monitored, and the incidence of osteoporotic fractures was assessed.Results: The urinary level of cross-linked N-terminal telopeptides of type I collagen and serum level of alkaline phosphatase significantly decreased (-42.5% at 3 months and -18.9% at 3 years, and the lumbar spine BMD, but not the total hip BMD, significantly increased (14.8% at 3 years, compared with the baseline values. However, the incidence of vertebral and nonvertebral fractures was 26.5% and 2.9%, respectively, suggesting a high incidence of vertebral fractures.Conclusion: The results of the present study suggest that combined treatment with alendronate and alfacalcidol may be useful to reduce bone turnover and increase the lumbar spine BMD in patients with severe bone loss and osteoporotic fracture. However, its efficacy against vertebral fractures appears not to be sufficient. Thus, anabolic agents such as teriparatide should be taken into consideration as first-line drugs in patients with severe osteoporosis.Keywords: osteoporosis

  5. Arnold Chiari Malformation With Sponastrime (Spondylar and Nasal Changes, With Striations of the Metaphyses) Dysplasia

    Science.gov (United States)

    Jeong, Je Hoon; Lee, A Leum; Cho, Sung Yoon; Jin, Dong Kyu; Im, Soo-Bin

    2016-01-01

    Abstract SPOndylar and NAsal changes, with STRIations of the Metaphyses (SPONASTRIME) dysplasia (SD) is a dwarfing autosomal recessive syndrome, characterized by a variety of clinical and radiographic features, which form the basis for diagnosis. We describe the presentation of an Arnold Chiari malformation in a patient with a clinical diagnosis of SD. The malformation was successfully treated by decompression of the foramen magnum and elevation of the cerebellum, with complete resolution of pain. We report a rare case of Arnold Chiari malformation in a patient presenting with clinical and radiographic features strongly suggestive of SD and be successfully treated. PMID:27149441

  6. Aqueous extract of pomegranate seed attenuates glucocorticoid-induced bone loss and hypercalciuria in mice: A comparative study with alendronate.

    Science.gov (United States)

    Zhang, Yan; Shao, Jin; Wang, Zhi; Yang, Tieyi; Liu, Shuyi; Liu, Yue; Fan, Xinbing; Ye, Weiguang

    2016-08-01

    The present study was performed in order to examine bone loss and calcium homeostasis in mice with glucocorticoid (GC)-induced osteoporosis (GIOP) following treatment with the aqueous extract of pomegranate seed (AE-PS). In addition, a comparative study with alendronate was performed. Biomarkers in the serum and the urine were measured. The tibias, kidney and duodenum were removed in order to measure the levels of bone calcium, protein expression as well as to perform histomorphological analysis of the bone. GC treatment facilitated the induction of hypercalciuria in the mice, and the AE-PS‑treated mice exhibited a greater increase in serum calcium and a decrease in urine calcium. The AE-PS reversed the deleterious effects on the trabecular bone induced by DXM and stimulated bone remodeling, including an increase in bone calcium and alkaline phosphatase‑b (ALP-b) and a decrease in a the critical bone resorption markers C-terminal telopeptide of type I collagen (CTX) and tartrate‑resistant acid phosphatase-5b (TRAP-5b). Hematoxylin and eosin (H&E) staining revealed the increased disconnections and separation between the growth plate and the trabecular bone network as well as the reduction in the trabecular bone mass of the primary and secondary spongiosa throughout the proximal metaphysis of the tibia in the DXM group. Moreover, the decreased protein expression of transient receptor potential vanilloid (TRPV)5, TRPV6 and calbindin‑D9k (CaBP‑9k) was reversed by the AE-PS or alendronate supplementation in the kidneys and the duodenum as well as plasma membrane Ca2+‑ATPase1 (PMCA1) expression in the kidneys of mice with GIOP. There was no marked difference in pharmacological effectiveness between alendronate and the AE-PS. Taken together, these findings suggest that the AE-PS may be an alternative therapy suitable for use in the management of secondary osteoporosis. PMID:27278225

  7. Metaphysical labour

    OpenAIRE

    Raastrup Kristensen, Anders

    2009-01-01

    This thesis offers a critical contribution to the theories of work-life balance. Within the contemporary theoretical perspectives on work and life the individuals are constructed as being responsible for work-life balance by turning it into a problem of the personal behaviour, decisions, psychological traits and family condition of the human subject. In this sense the everyday problem of balancing between work and home is reduced to be primarily an individual problem and decisi...

  8. Metaphysical green

    DEFF Research Database (Denmark)

    Earon, Ofri

    2011-01-01

    of Sensation of Green is created by a physical interaction between the language of space and the language of nature” The notion of Sensation of Green was developed through a previous study ‘Learning from the Summer House’ investigating the unique architectural characteristics of the Danish summer houses...... the Sensation of Green? Three existing examples are agents to this discussion. The first example is a Danish summer house. The other two are international urban examples. While the summer house articulates the original meaning of Sensation of Green, the urban examples illustrate its urban context. The first...... example is a tiny Danish summer house from 1918 . The second example is ‘House before House’ , in Tokyo. The third example is a prefabricated house ‘CHU’ . The analysis evaluates the characteristics of diverse tones of green – from green image to green sensation. The analysis is based on the original...

  9. Copernican Metaphysics

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    Paul Ennis

    2011-06-01

    Full Text Available In the Kritik der reinen Vernunft (1781 Kant introduced the transcendental method on a precarious footing and he never shied away from the fact that the transcendental method is structured, and I mean it in the most direct sense possible, aporetically. The aporetic element, the unstable core within Kantian thought, is the distinction between phenomenal and noumenal content in the chapter entitled "On the ground of the distinction [Unterscheidung] of all objects [Gegenstände] in general into phenomena and noumena" (Kant A236/B295-A260/B315. This distinction is noteworthy for introducing into the philosophical tradition the notion of the thing-in-itself [Ding-an-sich]. Depending on your interests this is either the most profound or absurd of ideas in our tradition. I prefer to think of it as the most productive notion in our tradition. We can see its generative function at work almost immediately when it spurred the German idealists into thinking obscenely ingenious thoughts, but the phenomenal-noumenal distinction, hereafter the aporetic distinction, remains an ever-persistent aporia for all continental thinking after Kant. In this article I want to focus on how the aporetic distinction functions in its generative capacity with an emphasis on its ontological rather than epistemological register. Considered as such I claim that it is possible to identify in the aporetic distinction a generative capacity (or logic or function that is intrinsic to both it and all thought responding to it including, or perhaps especially, the speculative responses.

  10. Category of time in Christian metaphysics: Gregory of Nyssa and Maximus the Confessor

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    Mikhaylov, Petr

    2015-01-01

    Full Text Available In the article a problem of time is posed as an object of Christian theological reflection developed in a complicated interweaving of philosophical, cultural and religious traditions of the Mediterranean civilization. A typology of the problem is established by a correlation of the category of time with different aspects of temporality – with eternity in Antiquity, with future in Modernity and with present in the thought of different authors belonging to different epochs. The most representative thinkers of Christian metaphysic, viewed against this background, are Gregory of Nyssa (the 4th c. and Maximus the Confessor (the 7th c.. The former has successfully reinterpreted time as being-to-salvation rather than being-to-destruction. Gregory solves the problem of time by introducing an original concept of a dynamical static, or a statical dynamic, using the principle of epektasis as a general tool. In that case, time becomes a kind of spiritual practice. Maximus resolves the problem in a more traditional manner. He speaks about an overcoming of time in the perspective of divine eternity; Gregory on the contrary presupposes its transfiguration. Thereby Christian metaphysic offers a number of possibilities for a theological solution of the eternal question about time.

  11. The Metaphysic of Encounter of Space at the Meet of Persian Miniature with Renaissance Painting

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    abdollah aghaie

    2015-03-01

    Full Text Available Persian miniature was showing itself as dynamic during dialogue with “other” visual traditions (Specially Eastern ones. But it seems that meet renaissance painting was a kind of “encounter” to a strange matter for it. The most substantial part of this encounter is incompatibility of whose perception of space. Since that the conception of space is related to basic principle of representation. What this paper has focused on, is “the reason” of this encounter. With the help of philosophical approach this paper is trying to answer the question. So is to shed light on metaphysics foundation that make possible rise of conception of space in both side. By using the conception of “the mathematical” in Heidegger philosophy, it is shown that how ascend of modern metaphysic was lead to quantitative perception of space in renaissance painting, and at the other hand how using a qualitative perception of space in Persian miniature opposing to modern perspective of space.

  12. To weave the forms of Mystery: Travel, mystical and metaphysical in Sufi poetry

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    Daniel Del Percio

    2015-04-01

    Full Text Available Mystery is not just an enigma but a force, an impulse that gives emphasis to the real. And the ways in which this mystery unfolds are probably endless. In Sufism, travel literature is established as the quintessential poetic mysticism, where the description of incessant movement throughout the world invariably takes the value of metaphysical experience, freedom of spirit, understanding of the presence of the divine in every aspect and at every step of the journey. A mystic is a “nomadic metaphysics”, able to describe the man, the cosmos and God himself as travelers. Among the Sufi mystic poets, stands the figure of Ibn ‘Arabi, Andalusian born in Murcia in 1165 and died in Damascus in 1240. His particular metaphysics, Neoplatonist undeniable base, conceived not as a system but as a poetic movement, is a unique interface between East and West philosophies. This is observable in his works The Seals of Wisdom (Fusus al-Hikam and, especially, The splendor of the fruits of the trip (Kitab al-Isfar ‘an al-asfar nata’iy, which we will study in this work.

  13. Metaphysical Modality, Modality of Predicate and the Theory of "Decisive Necessity”

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    L. Nabavi

    2010-01-01

    Full Text Available Aristotle in the Organon (1949: 9,30 a ,15-19 explicitly states that in a categorical syllogism when the minor premise is absolute (without modality operator and the major is necessary, the conclusion will be necessary too. This Aristotle's view has been the source of many conflicts and disputes in the history of logic. The famous logicians and historians of logic in the twentieth century as "Nicholas Rescher" and "Becker" believe that Aristotle's view is justifiable and defensible (at least compared to the first figure only if, the modality of major premise is considered as the property of predicate (modality de re. Today, we know very well that the modality of predicate is closely linked to Metaphysical and philosophical Modality. “Shihab al-Din al- Suhrawardi” in the theory of "Decisive (Battateh Necessity” by accepting this base, explicitly states that, in the beginning, the modality must be mentioned as a part of the predicate and then the modality of relation or copula is summarized and reduced to necessity. The modern formalization of the most important part of this theory is as follows: ("x (àAx É à Bx º ("x □ (àAx É à BxThis paper discusses the historical overview of the metaphysical modality firstly and then shows that the theory of "Decisive Necessity” is true and justified in a model of modal logic with equivalent accessibility relation and homogeneous possible world view (fixed domain.

  14. Subtrochanteric and diaphyseal femur fractures in patients treated with alendronate: a register-based national cohort study

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Eiken, Pia; Eastell, Richard

    2009-01-01

    found that 7% of patients with atypical fractures were aln exposed, and the same was found for typical hip fractures. In the cohort study, the HR for subtrochanteric/diaphyseal fracture with aln was 1.46 (0.91-2.35, p = 0.12) compared with 1.45 (1.21-1.74, p fracture after adjustment......Alendronate (aln) is a potent bisphosphonate with a prolonged duration of action. Recent reports have found long-term aln use to be common in patients with subtrochanteric or proximal diaphyseal femur fracture, raising concerns that these fractures could be a consequence of excessive suppression...... of bone turnover. Two national observational register-based studies were performed: (1) cross-sectional study (N = 11,944) comparing age distribution, exposure, and trauma mechanisms between different types of proximal femur fractures and (2) matched cohort study in patients with prior nonhip fractures (N...

  15. Fraturas transtrocanterianas: uso de alendronato no pós-operatório Transtrochanterian fractures: postoperative use of alendronate

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    Francisco José Nunes Cardoso

    2011-01-01

    Full Text Available OBJETIVO: Avaliar resultados do uso de alendronato de sódio em pós operatório de fratura transtrocanteriana. MÉTODO: Durante seis meses, 75 pacientes foram atendidos no Serviço de Ortopedia devido à fratura transtrocanteriana de fêmur, sendo submetidos a tratamento cirúrgico com fixação através de placa DHS 135°. Foram selecionados 19 pacientes, hígidos, cooperativos, previamente deambuladores, classificados segundo Tronzo em tipo III e cujos quadris contra laterais não haviam sido submetidos a nenhuma cirurgia prévia, permitindo a realização de Densitometria Óssea Mineral no pós-operatório imediato e após seis meses. Os pacientes foram divididos em grupos I e II, com e sem uso de alendronato de sódio, a partir do pós-operatório imediato, respectivamente. O seguimento mínimo foi de seis meses. Após quatro semanas, os pacientes foram avaliados de acordo com a Escala Visual Analógica de Dor (EVA, para observação do índice de reabsorção óssea, a massa óssea e a consolidação radiológica da fratura. RESULTADOS: Houve uma tendência estatística de consolidação radiológica mais precoce com menor reabsorção óssea nos pacientes com uso de alendronato de sódio na pós-fratura com osteoporose estabelecida. CONCLUSÃO: Concluímos que, radiologicamente, os pacientes que utilizaram alendronato de sódio tiveram uma consolidação óssea mais rápida, com menor índice de reabsorção.OBJECTIVE: To evaluate the results of the use of alendronate sodium in postoperative transtrochanteric femoral fractures. METHOD: Over a six-month period, 75 patients were treated at the Orthopedic Service for transtrochanteric femoral fractures, undergoing surgery with 135 degree DHS plate fixation. We selected 19 patients who were healthy, cooperative, previously unable to walk, classified as type III according to Tronzo, whose contralateral hips had not undergone any previous surgery, enabling the evaluation of bone mineral density

  16. Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status

    Science.gov (United States)

    Evans, Sally F.

    2016-01-01

    Aims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men. Methods. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular) and 2 diaphyseal (mainly cortical)). BMD at femoral neck (FN) and lumbar spine L2–4, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH), and urinary calcium and NTx/Cr, a measure of bone breakdown, were also measured. Age matched healthy men provided values for BMD calculation of z and T scores and for biochemical measurements. Results. Low BMD z scores were found at metaphyseal regions in the leg (p < 0.001) and in the FN (p < 0.05). The distal metaphyseal region BMD in the leg was lower than spine or FN (p < 0.05). PTH, urinary calcium/creatinine, and urinary NTx/Cr were similar to controls. Both metaphyseal and diaphyseal BMD z scores were associated with body weight (p < 0.02), but not with either PTH or urinary NTx/Cr. Conclusions. Low BMD lower limb regions comprising mostly trabecular bone occur early in CD and in the absence of elevated PTH or increased bone resorption. Low BMD is associated with low body weight.

  17. Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status

    Directory of Open Access Journals (Sweden)

    Michael W. J. Davie

    2016-01-01

    Full Text Available Aims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men. Methods. From whole body DXA scans bone mineral density (BMD was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular and 2 diaphyseal (mainly cortical. BMD at femoral neck (FN and lumbar spine L2–4, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH, and urinary calcium and NTx/Cr, a measure of bone breakdown, were also measured. Age matched healthy men provided values for BMD calculation of z and T scores and for biochemical measurements. Results. Low BMD z scores were found at metaphyseal regions in the leg (p<0.001 and in the FN (p<0.05. The distal metaphyseal region BMD in the leg was lower than spine or FN (p<0.05. PTH, urinary calcium/creatinine, and urinary NTx/Cr were similar to controls. Both metaphyseal and diaphyseal BMD z scores were associated with body weight (p<0.02, but not with either PTH or urinary NTx/Cr. Conclusions. Low BMD lower limb regions comprising mostly trabecular bone occur early in CD and in the absence of elevated PTH or increased bone resorption. Low BMD is associated with low body weight.

  18. Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status

    Science.gov (United States)

    Evans, Sally F.

    2016-01-01

    Aims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men. Methods. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular) and 2 diaphyseal (mainly cortical)). BMD at femoral neck (FN) and lumbar spine L2–4, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH), and urinary calcium and NTx/Cr, a measure of bone breakdown, were also measured. Age matched healthy men provided values for BMD calculation of z and T scores and for biochemical measurements. Results. Low BMD z scores were found at metaphyseal regions in the leg (p < 0.001) and in the FN (p < 0.05). The distal metaphyseal region BMD in the leg was lower than spine or FN (p < 0.05). PTH, urinary calcium/creatinine, and urinary NTx/Cr were similar to controls. Both metaphyseal and diaphyseal BMD z scores were associated with body weight (p < 0.02), but not with either PTH or urinary NTx/Cr. Conclusions. Low BMD lower limb regions comprising mostly trabecular bone occur early in CD and in the absence of elevated PTH or increased bone resorption. Low BMD is associated with low body weight. PMID:27672477

  19. Transcendence in the current theology, philosophy and metaphysics in Russian cosmism

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    Emanuel George Oprea

    2016-03-01

    Full Text Available Human interests to Religion and Metaphysics are well explained by the desire of the people to answer to fundamental and eternal questions as “what is the sense of life” and “what is the purpose of life”. These questions have accompanied them from the beginning of conscious life. Many intellectuals, scientists and writers of former USSR and democratic Russia have brought essential contributions, opened new directions and finally have enriched with new concepts, ideas, ideologies and systems the worldwide Philosophy and Religion. A possible answer is the Creation allowing to Divinity to transcend in common life. Soul as Spiritual reflection of Divinity tends to perfection, reiterating in every generation the transcendence to God. At first sight there are no meeting points between Transcendence and Cosmism because the last notion has its beginning in the progress of Science. The evolution of modern Sciences, philosophical concepts and Religion gradually demonstrates correlated aspects which must be discovered in the future.

  20. The Metaphysical Dimension of Pedagogy%教育学的玄学之维

    Institute of Scientific and Technical Information of China (English)

    谭维智

    2012-01-01

    Besides the scientific dimension, pedagogy also has a metaphysical dimension. Metaphysics deals with the mind and spirit of human beings through examining the internal world by means of introspection and interpretation, which focuses on the issues of the spirit and soul of people that science is unable to touch upon. The inner space of education is a domain that science can not reach. The ultimate goal of education aims to realize the conversion and promotion of heart and nature. In other words, education should accomplish internal comprehension, moral wisdom, contemplative insights, interpretation of knowledge as well as introspective perception and aesthetic performance, which can not be realized only by relying on scientific ways. Consequently, metaphysics is an alternative way to think about education. There are many differences between educational knowledge and natural scientific knowledge in the ways of playing their roles, which requires different research methods. Currently, the metaphysical trend has appeared from the emphasis on knowledge and skill to spiritual development, internal cognition and comprehension around the world.%在教育学的科学维度之外,还有一种玄学维度。玄学是以内省、诠释的方式对内在世界进行领会,它回答的是科学无法涉及的关于人的精神、心灵的问题。教育的内在空间是科学所无法、无力达至的领地,教育最终要实现的是心、性的转化和提升,要达成内在领悟、道德智慧、默观洞见、诠释知识、内省感知、美感表现,这些方面不能完全靠科学化的路径,而是要从“玄”门进入。,教育中知识发挥作用的方式与自然科学中知识的“运动方式”是完全不同的,我们不能用对待自然知识的方式(科学)对待教育中的知识。当前,在世界范围内,教育学研究已经出现一种由重视知识技能的掌握向重视心灵发展、内在认知、内在领悟的玄学转向。

  1. Borrowed philosophy: bedside physicalism and the need for a sui generis metaphysic of medicine.

    Science.gov (United States)

    Whatley, Shawn D

    2014-12-01

    The character of medicine has changed over the last 100 years such that medicine is more interested in diseases than the people who suffer from them. Despite notable efforts to address this, the medical humanities do not challenge doctors' fundamental view of the world. Students adopt a metaphysic of physicalism during basic science training that gets carried into medical training. While necessary for medical science, physicalism is insufficient for clinical care. Physicalism offers no foundation for the sine qua non of medicine, the doctor-patient relationship. The character of medicine will not see a renewed interest in humanity until educators address the insufficiency of physicalism for clinical care, and clinicians partner with experts in the humanities to build a sui generis philosophy of medicine.

  2. On Darwin's 'metaphysical notebooks'. I: teleology and the project of a theory.

    Science.gov (United States)

    Calabi, L

    2001-01-01

    Huxley's essay On the Reception of the 'Origin of Species' brings us close to the issue of cause and of why- and how-questions in the understanding of the living world. The present contribution, which is divided into two parts, reviews the problem of Teleology as conceived by Huxley and re-examines Darwin as the author who revealed the existence of a 'foundations problem' in the explanation of an entire realm of nature, i.e., the problem of explaining such realm in terms of its own, specific legality, or iuxta sua propria principia. In the first part the enquiry is mainly focused on the secularization of natural history after Paley; in the second part it is mainly focused on the desubjectivization of the inquiry into natural history after Erasmus Darwin and Lamarck. The second part will be published in the next issue of Rivista di Biologia/Biology Forum. In the first part below an analysis is made of Notebooks M and N. The author disputes the correctness of conceiving them only as the works where Darwin envisages the 'metaphysical' themes later to become the subject of The Expression of the Emotions. He suggests to conceive of them also as the works where Darwin defines the terms of the general project of his own, peculiar evolutionary theory. The author then outlines the intellectual progress of Darwin from the inosculation to the transmutation hypotheses. Darwin's reading of Malthus appears to be analytically decisive, because it offers him the vintage point to attack the metaphysical and theological citadels on the morphological side. Darwin is thus able to re-consider Erasmus' comprehensive zoonomic project, by displacing it, however, from the old idea of the scala naturae to the new one of the "coral of life", and by emphasising the distinction between "the fittest" and "the best" vs. the tradition of Natural Theology.

  3. Metaphysics within the Limits of Phenomenology: Balthasar and Husserl on the Nature of the Philosophical Act

    Directory of Open Access Journals (Sweden)

    David C Schindler

    2009-01-01

    Full Text Available This article compares the accounts Edmund Husserl and Hans Urs von Balthasar offer of the ultimate philosophical act: the transcendental reduction and contemplation of the fourfold difference, respectively. It argues that Husserl's method precludes from the outset the raising of the question of being, and that as a consequence, all four of the distinctions that Balthasar describes must ultimately collapse in his phenomenology. An adequate response to Husserl must attend, at least implicitly, to the whole of the fourfold difference in all of its dimensions. The article concludes with a brief reflection on the significance of metaphysics for Christianity and the significance of Christianity for metaphysics.Este artículo compara los relatos que ofrecen Edmund Husserl y Hans Urs von Balthasar sobre el acto definitivo filosófico: la reducción trascendental y la contemplación de la diferencia de cuatro partes, respectivamente. Postula que el método de Husserl impide desde el principio la consideración de la cuestión del ser, y, en consecuencia, todas las cuatro distinciones que Balthasar describe deben derrumbarse en su fenomenología, al final. Una respuesta adecuada a Husserl debe atender, por lo menos implícitamente, al conjunto de la diferencia de cuatro partes en todas sus dimensiones. Este artículo concluye con una breve reflexión sobre el significado de la metafísica para el cristianismo y el significado del cristianismo para la metafísica.

  4. Descartes and the “metaphysical dualism”: Excesses in interpreting a classic

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    Ştefan Afloroaei

    2010-06-01

    Full Text Available The article focuses on one of the most serious accusations brought against Descartes and modern philosophy, namely “the dualism of substance”. The accusers claim that the human body and soul were viewed as completely separate; consequently, their relationship as such and the united being of man become incomprehensible. As has been shown above, the idea of the separation of the soul from the body did not originate with Descartes; it was formulated much earlier, and repeated by a disciple of Descartes’, Henry Leroy, known as Regius. When Descartes became aware of this bizarre interpretation he was dismayed and sought to clarify the matter. He sought to distinguish between two terms, “distinction” and “separation” and to illuminate the relationship between body and soul at three different levels, i.e. ordinary experience, analytical mind and metaphysical meditation.Eventually, he embraced the paradox of the two natures – the double substantial make-up of the human being, a paradox of patristic inspiration. However, the later history of ideas was not sympathetic to Descartes: nowadays, when one looks up the term “metaphysical dualism” in dictionaries or glossaries, even in the studies of prestigious researchers, one will find views similar to those of the unfaithful disciple Regius. The resilience of this locus obscurus is explained both by the power of a new mode of interpreting discourse (as technical or logical analysis and by the ever more privilegedposition of the reader (intentio lectoris. Both attitudes are related to modern ideologies and to changes which have occurred in the intersubjective lifeworld, especially in the communication of the scholarly and academic world.

  5. Comparative bone uptake study of alendronate sodium from vaginal suppositories prepared with polyethylene glycol and massa estarinum bases

    Directory of Open Access Journals (Sweden)

    Derya İlem-Özdemir

    2013-09-01

    Full Text Available The aim of this study was to compare the bone uptake of alendronate sodium (ALD from vaginal suppositories prepared with massa estarinum AB (ME and polyethylene glycol 1500 (PEG bases. For this purpose, ALD was radiolabeled with 99mTecnetium Pertechnetate (99mTc by direct method. Radiochemical purity and stability of 99mTc-ALD was performed with chromatographic studies. 99mTc-ALD containing suppositories were prepared with ME and PEG bases. Physical properties of suppositories were evaluated. The physicochemical diffusion study was carried out to compare the release of ALD from different suppository bases. The bone uptake of 99mTc-ALD was observed by gamma scintigraphy studies. 99mTc-ALD containing suppositories were administrated to rabbits via vaginal route. The scintigraphic images were obtained with a gamma camera at different time intervals up to 240 minutes. According to our studies, radiochemical purity of 99mTc-ALD was observed more than 95% up to 6 hours. At 240 minutes of physicochemical diffusion studies, released ALD has 0.620 ± 0.091 mm and 10.465 ± 0.651 mm diameter zone from ME and PEG base suppositories respectively. According to the gamma scintigraphy studies, although no bone uptake observed after ME suppositories application, rabbit’s bones were clearly visible after PEG suppositories applied. The results of physicochemical diffusion and gamma scintigraphy studies were found compatible in each other

  6. Rumford and the Reflection of Radiant Cold: Historical Reflections and Metaphysical Reflexes

    Science.gov (United States)

    Chang, Hasok

    2002-05-01

    In this paper I examine the debate regarding the positive reality of cold: whether it is merely an absence of heat, or a quality or entity in its own right. Marc-Auguste Pictet stimulated this debate by showing that radiation from a cold object apparently could be focused by concave mirrors to cool another object some distance away from it. Pictet and other believers in material theories of heat, most notably Pierre Prevost, sought to understand this phenomenon as a result of the radiation of caloric in a peculiar arrangement. By contrast, Count Rumford saw in Pictet's experiment a genuine action of "frigorific rays," and performed striking new experiments to support his view. For Rumford heat and cold radiation consisted in sound-like undulations in the ether, a mechanism compatible with his own vibration theory of heat, and discordant with the caloric theory. Rumford's strong arguments were overruled only because of the general dominance of the caloric theory of heat. However, Rumford did push the caloric theory to develop in a direction that eventually led to its downfall. I revisit this debate without preconceived notions of the metaphysical nature of cold and heat.

  7. The Existential Turn: Reappraising Being and Time’s Overcoming of Metaphysics

    Directory of Open Access Journals (Sweden)

    Rufus Duits

    2010-06-01

    Full Text Available The task of this paper is to propose an answer to these relatedquestions. It amounts to an attempt to work through conceptually step by step Heidegger’s so called “overcoming of metaphysics”. It is true of course that the locution, “the overcoming of metaphysics”, does not appear in Being and Time. The discourse of the overcoming of metaphysics is held by Heidegger’s commentators to belong to a period post-dating the early work, after the so called Kehre. I shall stubbornly evade this knotty issue of Heidegger interpretation here. For my purposes it suffices merely if our understanding ofBeing and Time, its content, intent and consequence, can be deepened or expanded if it is read in the light of the task of overcoming metaphysics—or at least in the light of that task as it is to be conceived in the context I shall present here. What is to be understood by the phrase “the overcoming of metaphysics”?

  8. Dynamic and stochastic systems as a framework for metaphysics and the philosophy of science

    CERN Document Server

    List, Christian

    2015-01-01

    Scientists often think of the world (or some part of it) as a dynamical system, a stochastic process, or a generalization of such a system. Prominent examples of systems are (i) the system of planets orbiting the sun or any other classical mechanical system, (ii) a hydrogen atom or any other quantum-mechanical system, and (iii) the earth's atmosphere or any other statistical mechanical system. We introduce a simple and general framework for describing such systems and show how it can be used to examine some familiar philosophical questions, including the following: how can we define nomological possibility, necessity, determinism, and indeterminism; what are symmetries and laws; what regularities must a system display to make scientific inference possible; is there any metaphysical basis for invoking principles of parsimony such as Occam's Razor when we make such inferences; and what is the role of space and time in a system? Our framework is intended to serve as a toolbox for the formal analysis of systems t...

  9. Gadolinium-enhanced MR Imaging of Epiphyseal and Metaphyseal Marrow in Normal Piglets

    Institute of Scientific and Technical Information of China (English)

    LI Xiaoming; WANG Renfa; QI Jianpin; TANG Lihua

    2005-01-01

    The purpose of this study is to define the appearance of normal epiphyseal and metaphyseal marrow and normal changes of marrow due to fatty conversion on Gadolinium (Gd)-enhanced MR Imaging. Unenhanced and enhanced T1-weighted MR imaging were performed in proximal and distal femoral ends of 8 healthy piglets at the ages of 2, 4, 6 and 8 weeks, respectively. The changes with age in signal intensity and enhancement ratio of the epiphyseal and tnetaphyseal marrow with age were examined. The correlation of MRI characteristics with histological findings was studied. Our study showed that marrow of the metaphysis and of periphery of the 2nd ossification center were well vascularized hematopoietic marrow and had great enhancements. The enhancement ratio of metaphysis was greater than that of epiphyseal marrow and both enhancement ratios degraded gradually with age. The central regions of the epiphyseal ossification center and of the diaphysis were of fatty marrow and had little enhancement. It is concluded that on Gd-enhanced MR imaging the hematopoietic marrow of metaphysis and of periphery of the 2nd ossification center had greater enhancement than that of fatty marrow of central region of the 2nd ossification center. All of their enhancements decreased gradually with age.

  10. The uncertain foundation of neo-Darwinism: metaphysical and epistemological pluralism in the evolutionary synthesis.

    Science.gov (United States)

    Delisle, Richard G

    2009-06-01

    The Evolutionary Synthesis is often seen as a unification process in evolutionary biology, one which provided this research area with a solid common theoretical foundation. As such, neo-Darwinism is believed to constitute from this time onward a single, coherent, and unified movement offering research guidelines for investigations. While this may be true if evolutionary biology is solely understood as centred around evolutionary mechanisms, an entirely different picture emerges once other aspects of the founding neo-Darwinists' views are taken into consideration, aspects potentially relevant to the elaboration of an evolutionary worldview: the tree of life, the ontological distinctions of the main cosmic entities (inert matter, biological organisms, mind), the inherent properties of self-organizing matter, evolutionary ethics, and so on. Profound tensions and inconsistencies are immediately revealed in the neo-Darwinian movement once this broader perspective is adopted. This pluralism is such that it is possible to identify at least three distinct and quasi-incommensurable epistemological/metaphysical frameworks as providing a proper foundation for neo-Darwinism. The analysis of the views of Theodosius Dobzhansky, Bernhard Rensch, and Ernst Mayr will illustrate this untenable pluralism, one which requires us to conceive of the neo-Darwinian research agenda as being conducted in more than one research programme or research tradition at the same time.

  11. 阿仑膦酸钠与雷洛昔芬对牙槽骨吸收的影响*%Alendronate and raloxifene affect alveolar bone resorption

    Institute of Scientific and Technical Information of China (English)

    陈锦波; 刘铁玉; 阎美凤; 曲晓娟

    2013-01-01

      背景:研究证明阿仑膦酸钠与雷洛昔芬对骨质疏松有抑制作用。目的:建立实验性大鼠骨质疏松及牙槽骨吸收模型,评价阿仑膦酸钠与雷洛昔芬对骨吸收的防治作用。方法:56只雌性 SD 大鼠建立骨质疏松及牙槽骨吸收的动物模型,实验动物分组:①去势+结扎组和单纯结扎组又分别分为3个亚组:阿仑膦酸钠组、雷洛昔芬组和非用药组。②单纯去势非用药组。③假手术组做空白对照。建模手术后第5日开始灌胃给药,1次/d,治疗3个月。用血生化指标、骨密度测量及组织形态学方法进行药效评价。结果与结论:阿仑膦酸钠治疗组较雷洛昔芬组有更强的降低去势组碱性磷酸酶和血钙的作用;提高去势组骨密度。结果证实阿仑膦酸钠与雷洛昔芬均能减少骨质丢失,从而可以防止骨质疏松及病理性牙槽骨骨吸收,且阿仑膦酸钠作用较好。%BACKGROUND: Studies have shown that alendronate and raloxifene can suppress osteoporosis. OBJECTIVE: To evaluate the anti-osteoporosis effect of alendronate and raloxifene in rat models of osteoporosis and alveolar bone resorption. METHODS: Total y 56 female Sprague-Dawley rats were enrol ed to establish animal models of osteoporosis and alveolar bone resorption. Ovariectomized+ligation group and ligation group were respectively divided into three subgroups: alendronate, raloxifene and non-drug groups. Ovariectomized group and sham operation group (blank control) were set. Intragastric administration was performed at 5 days after modeling, once a day, total y for 3 months. Blood biochemical markers, bone mineral density measurement and histomorphological method were done for evaluation of drug effectiveness. RESULTS AND CONCLUSION: As compared with the raloxifene groups, alendronate groups could significantly reduce alkaline phosphatase and serum calcium levels and promote bone mineral density in the

  12. Evaluation of the topical effect of alendronate on the root surface of extracted and replanted teeth. Microscopic analysis on rats' teeth.

    Science.gov (United States)

    Lustosa-Pereira, Adriana; Garcia, Roberto Brandão; de Moraes, Ivaldo Gomes; Bernardineli, Norberti; Bramante, Clovis Monteiro; Bortoluzzi, Eduardo Antunes

    2006-02-01

    The treatment of choice for tooth avulsion is replantation. The ideal replantation should be realized as quickly as possible, or at least, the avulsed tooth should be kept in an adequate solution to preserve the periodontal ligament attached to the root. If that is not possible, treatment of the radicular surface should be done in order to prevent radicular resorption. The purpose of this study was to test sodium alendronate as a substance for topical treatment of the radicular surface of avulsed teeth in an attempt to prevent the occurrence of dental resorptions. Fifty-four rat maxillary right central incisors were extracted and replanted. Group I--extra-alveolar dry period of 15 min, intracanal dressing with calcium hydroxide (CALEN, S.S. White, Artigos Dentários LTDA, Rio de Janeiro, Brazil) and replantation; Groups II and III - extra-alveolar dry periods of 30 and 60 min, respectively, immersion in 1% sodium hypochlorite for 30 min for removal of the periodontal ligament, washing in saline solution for 5 min, and treatment of the radicular surface with 3.2 mg/l sodium alendronate solution for 10 min. Intracanal dressing with calcium hydroxide and replantation followed. At 15, 60, and 90 days post-reimplantation, the animals were killed and the samples obtained and processed for microscopic analysis. The results indicated that sodium alendronate was able to reduce the incidence of radicular resorption, but not of dental ankylosis. No significant differences were observed regarding variations in the extra-alveolar periods among the groups. PMID:16422756

  13. Five-year alendronate treatment outcome in older postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures

    Directory of Open Access Journals (Sweden)

    Jun Iwamoto

    2009-09-01

    Full Text Available Jun Iwamoto1, Atsushi Miyata2, Yoshihiro Sato3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Internal Medicine, Yahata Clinic, Tokyo, Japan; 3Department of Neurology, Mitate Hospital, Fukuoka, JapanAbstract: A retrospective study was conducted to evaluate the outcome of treatment with alendronate (ALN for 5 years in postmenopausal Japanese women with an increased risk of fractures. Forty postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures (mean age: 75.4 years were analyzed; 33 patients were treated with alendronate and 7 were treated with alfacalcidol (ALF, controls in an outpatient clinic run by general practitioners. The metacarpal bone mineral density (BMD measured using a computed X-ray densitometer, urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX, and serum levels of alkaline phosphatase (ALP were monitored during the 5-year treatment period. The urinary NTX and serum ALP levels decreased significantly in the ALN group, compared with the ALF group. The metacarpal BMD was sustained in the ALN group but decreased significantly in the ALF group; the difference between these two groups was also significant. The present study evaluated the outcome of treatment with ALN for 5 years in postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures. ALN successfully suppressed bone turnover and sustained the metacarpal BMD over the 5-year period of treatment in postmenopausal Japanese women with an increased risk of fractures.Keywords: alendronate, osteoporosis, osteopenia, risk factors for fractures, postmenopausal women

  14. Poly (L-lactide-co-e caprolactone) microspheres laden with bioactive glass-ceramic and alendronate sodium as bone regenerative scaffolds

    Energy Technology Data Exchange (ETDEWEB)

    Mondal, Titash [Sree Chitra Tirunal Institute of Medical Science and Technology, Biomedical Technology Wing, Thiruvananthpuram-695012 (India); Rubber Technology Centre, Indian Institute of Technology, Kharagpur-721302, West Bengal (India); Sunny, M.C. [Sree Chitra Tirunal Institute of Medical Science and Technology, Biomedical Technology Wing, Thiruvananthpuram-695012 (India); Khastgir, D. [Rubber Technology Centre, Indian Institute of Technology, Kharagpur-721302, West Bengal (India); Varma, H.K. [Sree Chitra Tirunal Institute of Medical Science and Technology, Biomedical Technology Wing, Thiruvananthpuram-695012 (India); Ramesh, P., E-mail: rameshsct@gmail.com [Sree Chitra Tirunal Institute of Medical Science and Technology, Biomedical Technology Wing, Thiruvananthpuram-695012 (India)

    2012-05-01

    Microspheric scaffolds of poly-(lactide-co-caprolactone) loaded with alendronate sodium, a family precursor of bisphosphonate drug and bioactive glass-ceramic (BGS) were prepared for the treatment of osteoporosis like bone defects with the rationale of getting a combined effect/concurrent advantage of osteoclast apoptosis as well as the augmentation of bone regeneration. The porous microspheres were generated by oil in water/solvent evaporation technique. The distribution of bioactive glass-ceramic was evidenced by the microcomputed tomography ({mu}-CT) and scanning electron microscopy analyses. The microspheres were evaluated for their in vitro cytocompatibility using L929 cell line and were found to be noncytotoxic. The osteoinductivity of the scaffold was assessed by its response in simulated body fluid and observed an excellent hydroxy carbonate apatite (HCA) layer formation on the surface which revealed the bone bonding and bone regeneration capability of the scaffold. The cell adhesion studies was performed with L-929 cell line and a marking cell growth on the surface as well as in the pores of the bioactive glass-ceramic as well as bioactive glass-ceramic cum drug incorporated microspheres was evidenced by the Confocal laser scanning microscopy (CLSM) investigation. No cell adhesion was observed onto the surface of the bare microspheres prepared by the copolymer alone where as the bioactive glass-ceramic and drug cum bioactive glass-ceramic loaded microspheres were found to promote the cell adhesion. The viability of the adhered cells on the microspheres was checked by flourescein diacetate (FDA) staining and it was observed that the adhered cells were viable and metabolically active. The release of the drug, alendronate sodium, directly into the problem site makes the presently prepared microsphere superior to the oral variety of drug available which is associated with oral discomfort and low bioavailability. - Highlights: Black

  15. The susceptive alendronate-treatment timing and dosage for osteogenesis enhancement in human bone marrow-derived stem cells.

    Directory of Open Access Journals (Sweden)

    Chih-Hsiang Chang

    Full Text Available Recent studies indicated that alendronate enhanced osteogenesis in osteoblasts and human bone marrow-derived stem cells. However, the time- and dose-dependent effects of Aln on osteogenic differentiation and cytotoxicity of hBMSCs remain undefined. In present study, we investigated the effective dose range and timing of hBMSCs. hBMSCs were treated with various Aln doses (1, 5 and 10 µM according to the following groups: group A was treated with Aln during the first five days of bone medium, groups B, C and D were treated during the first, second, and final five days of osteo-induction medium and group E was treated throughout the entire experiment. The mineralization level and cytotoxicity were measured by quantified Alizarin Red S staining and MTT assay. In addition, the reversal effects of farnesyl pyrophosphate and geranylgeranyl pyrophosphate replenishment in group B were also investigated. The results showed that Aln treatment in groups A, B and E enhanced hBMSC mineralization in a dose-dependent manner, and the most pronounced effects were observed in groups B and E. The higher dose of Aln simultaneously enhanced mineralization and caused cytotoxicity in groups B, C and E. Replenishment of FPP or GGPP resulted in partial or complete reverse of the Aln-induced mineralization respectively. Furthermore, the addition of FPP or GGPP also eliminated the Aln-induced cytotoxicity. We demonstrated that hBMSCs are susceptible to 5 µM Aln during the initiation stage of osteogenic differentiation and that a 10 µM dose is cytotoxic.

  16. Long-term effects of alendronate on fracture healing and bone remodeling of femoral shaft in ovariectomized rats

    Institute of Scientific and Technical Information of China (English)

    Ling-jie FU; Ting-ting TANG; Yong-qiang HAO; Ke-rong DAI

    2013-01-01

    Aim:To investigate the long-term effects of alendronate (Aln),a widely used oral bisphosphonate,on fracture healing and bone remodeling in ovariectomized rats.Methods:Adult female SD rats underwent ovariectomy,and then bilateral femoral osteotomy at 12 weeks post-ovariectomy.From d 2 post-ovariectomy,the animals were divided into 3 groups,and treated with Aln (3 mg·kg-1d-1,po) for 28 weeks (Aln/Aln),Aln for 12 weeks and saline for 16 weeks (Aln/Saline) or saline for 28 weeks (Saline/Saline).At 6 and 16 weeks post-fracture,the fracture calluses were examined with X-ray radiography,and biomechanical testing and histological analysis were performed.The calluses were labeled with tetracycline and calcein to evaluate the mineral apposition rate (MAR).Results:The fracture line was less distinct in the 2 Aln-treated groups at 6 weeks post-fracture,and disappeared in all the 3 groups at 16 weeks post-fracture.The size of the callus and radiographic density of the femora in the Aln/Aln group were the highest among the 3 groups at 6 and 16 weeks post-fracture.Similar results were observed in the ultimate load at failure and energy absorption.However,the treatment with Aln delayed endochondral ossification of the callus,and significantly increased the total sagittal-sectional area,percentage callus area and callus thickness,and decreased the MAR at 6 and 16 weeks post-fracture.Conclusion:In the ovariectomized rat model,Aln is beneficial for the mechanical properties of the callus,but delays callus remodeling by suppressing the remodeling of woven bone into lamellar bone.

  17. Comparative clinicoradiographical evaluation of effect of aminobisphosphonate (sodium alendronate) on peri-implant bone status: Controlled clinical trial

    Science.gov (United States)

    Aggarwal, Rajni; Babaji, Prashant; Nathan, S. Senthil; Attokaran, George; Santosh Kumar, S. M.; Sathnoorkar, Sharanpriya

    2016-01-01

    Aim: The present study aims to compare the peri-implant bone status around immediately loaded dental implants treated with aminobisphosphonate solution and untreated control implants in terms of clinical and radiographical parameters. Materials and Methods: A total of 24 patients were randomly divided equally into two groups. This study was conducted in accordance to the Helsinki's declaration of 1975, revised in 2000, and with the approval of the institutional ethical committee. In the control group after preparation, osteotomy sites were irrigated with normal saline solution, whereas in the test group osteotomy sites were irrigated with modified bisphosphonate solution and then TRX-OP, Hi-Tec dental implants were inserted. Clinical parameters, such as modified plaque and gingival index, probing depth, mobility, and radiographic parameters were recorded at baseline (0), 3, 6, and 9 months. Data analysis was performed using the Statistical Package for the Social Sciences version 17 for windows, and the statistical techniques employed were repeated measures analysis of variance, independent sample t-test, and paired sample t-test. Results: Reduction in mean radiographic bone levels (height) was observed on the mesial and distal aspect of the control group in comparison to its baseline at all intervals. In the test group, there was reduction in mean radiographic bone levels on mesial and distal aspect of the implant site in comparison to its baseline till 6-month follow up, however, at 9 month, there was gain in bone level on both mesial and distal aspect of implant. This represents the effectiveness of sodium alendronate in enhancing the bone formation. On comparison, between both groups on mesial and distal aspect of implants, statistically significant differences were observed at 3 and 9 months on mesial and distal aspect, respectively, without any clinical evidence of mobility in the test group. Conclusion: Implant site treated with aminobisphosphonate solution

  18. Effects of Long-Term Odanacatib Treatment on Bone Gene Expression in Ovariectomized Adult Rhesus Monkeys: Differentiation From Alendronate.

    Science.gov (United States)

    Muise, Eric S; Podtelezhnikov, Alexei A; Pickarski, Maureen; Loboda, Andrey; Tan, Yejun; Hu, Guanghui; Thomspon, John R; Duong, Le T

    2016-04-01

    Similar efficacy of the cathepsin K inhibitor odanacatib (ODN) and the bisphosphonate alendronate (ALN) in reducing bone turnover markers and increasing bone mineral density in spine and hip were previously demonstrated in ovariectomized (OVX)-monkeys treated for 20 months in prevention mode. Here, we profiled RNA from tibial metaphysis and diaphysis of the same study using Affymetrix microarrays, and selected 204 probe sets (p < 0.001, three-group ANOVA) that were differentially regulated by ODN or ALN versus vehicle. Both drugs produced strikingly different effects on known bone-related genes and pathways at the transcriptional level. Although ALN either reduced or had neutral effects on bone resorption-related genes, ODN significantly increased the expression of osteoclast genes (eg, APC5, TNFRSF11A, CTSK, ITGB3, and CALCR), consistent with previous findings on the effects of this agent in enhancing the number of nonresorbing osteoclasts. Conversely, ALN reduced the expression of known bone formation-related genes (eg, TGFBR1, SPP1, RUNX2, and PTH1R), whereas ODN either increased or had neutral effects on their expression. These differential effects of ODN versus ALN on bone resorption and formation were highly correlative to the changes in bone turnover markers, cathepsin K (Catk) target engagement marker serum C-terminal cross-linked telopeptide (1-CTP) and osteoclast marker tartrate resistant acid phosphatase isoform 5b (TRAP5b) in the same monkeys. Overall, the molecular profiling results are consistent with the known pharmacological actions of these agents on bone remodeling and clearly differentiate the molecular mechanisms of ODN from the bisphosphonates. © 2016 American Society for Bone and Mineral Research. PMID:26587671

  19. An Analysis of the Agency and Providence in Platonic, Aristotelian and Avicennan Metaphysics

    Directory of Open Access Journals (Sweden)

    S. Mahdi Emamijomeh

    2014-01-01

    Full Text Available The questions as to whether the cosmic order of this world is based on action/agent or not? And if an agent is involved and the world and what it contains have to be seen as action, could we declare the cosmic order a providential order? are among the problems which have always occupied the mind of philosophers.      Reading through Platonic corpse leads us to the conclusion that he has founded his metaphysics upon the very idea of world of ideas. According to his works and words, Plato is a proponent of the theory of ideas. As a matter of fact, Plato's metaphysics lies in the theory of ideas. Plato illustrates the general makeup of the world of ideas and the way sensible objects stand in relation with the beings dwelling in the latter world by the well-known cave allegory in the seventh book of Republic. In his view, whatever we find around ourselves not only are not authentic realities but rather they are merely shadows of the truth. Every phenomenon has an essence or reality which is known as its form. The idea of Good overshadows the other ideas insofar as these latter ideas or forms are seen as the effects of the former. It seems we can take God, the One, Absolute Good, Absolute Beauty and Good in itself as expressions of the same reality which Plato has used in different contexts through his works. Along these terms some other notions have also been brought up like intellect, divine intellect, Demiurge, ideas and the particulars of material world. By explaining Plato's taking of these notions and terms, we believe, one can discover Platonic ontological system.    In Republic, Plato argues that God is the creator of ideal bed and all other things, and he is the creator of intelligible entities (ideas. The One or reality as a whole not only contains ideas but the spirit too. The One is the final principle and the source of ideas and is beyond all human attributes. Having said these, it is not clear how reason gets itself related to the

  20. High-resolution CT with histopathological correlates of the classic metaphyseal lesion of infant abuse

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, Andy; Kleinman, Paul K. [Boston Children' s Hospital, Department of Radiology, Boston, MA (United States); McDonald, Anna G. [Office of the Chief Medical Examiner, Boston, MA (United States); Rosenberg, Andrew E. [University of Miami Hospital, Department of Pathology, Miami, FL (United States); Gupta, Rajiv [Massachusetts General Hospital, Department of Radiology, Boston, MA (United States)

    2014-02-15

    The classic metaphyseal lesion (CML) is a common high specificity indicator of infant abuse and its imaging features have been correlated histopathologically in infant fatalities. High-resolution CT imaging and histologic correlates were employed to (1) characterize the normal infant anatomy surrounding the chondro-osseous junction, and (2) confirm the 3-D model of the CML previously inferred from planar radiography and histopathology. Long bone specimens from 5 fatally abused infants, whose skeletal survey showed definite or suspected CMLs, were studied postmortem. After skeletal survey, selected specimens were resected and imaged with high-resolution digital radiography. They were then scanned with micro-CT (isotropic resolution of 45 μm{sup 3}) or with high-resolution flat-panel CT (isotropic resolutions of 200 μm{sup 3}). Visualization of the bony structures was carried out using image enhancement, segmentation and isosurface extraction, together with volume rendering and multiplanar reformatting. These findings were then correlated with histopathology. Study of normal infant bone clarifies the 3-D morphology of the subperiosteal bone collar (SPBC) and the radiographic zone of provisional calcification (ZPC). Studies on specimens with CML confirm that this lesion is a fracture extending in a planar fashion through the metaphysis, separating a mineralized fragment. This disk-like mineralized fragment has two components: (1) a thick peripheral component encompassing the SPBC; and (2) a thin central component comprised predominantly of the radiologic ZPC. By manipulating the 3-D model, the varying appearances of the CML are displayed. High-resolution CT coupled with histopathology provides elucidation of the morphology of the CML, a strong indicator of infant abuse. This new information may prove useful in assessing the biomechanical factors that produce this strong indicator of abusive assaults in infants. (orig.)

  1. High-resolution CT with histopathological correlates of the classic metaphyseal lesion of infant abuse

    International Nuclear Information System (INIS)

    The classic metaphyseal lesion (CML) is a common high specificity indicator of infant abuse and its imaging features have been correlated histopathologically in infant fatalities. High-resolution CT imaging and histologic correlates were employed to (1) characterize the normal infant anatomy surrounding the chondro-osseous junction, and (2) confirm the 3-D model of the CML previously inferred from planar radiography and histopathology. Long bone specimens from 5 fatally abused infants, whose skeletal survey showed definite or suspected CMLs, were studied postmortem. After skeletal survey, selected specimens were resected and imaged with high-resolution digital radiography. They were then scanned with micro-CT (isotropic resolution of 45 μm3) or with high-resolution flat-panel CT (isotropic resolutions of 200 μm3). Visualization of the bony structures was carried out using image enhancement, segmentation and isosurface extraction, together with volume rendering and multiplanar reformatting. These findings were then correlated with histopathology. Study of normal infant bone clarifies the 3-D morphology of the subperiosteal bone collar (SPBC) and the radiographic zone of provisional calcification (ZPC). Studies on specimens with CML confirm that this lesion is a fracture extending in a planar fashion through the metaphysis, separating a mineralized fragment. This disk-like mineralized fragment has two components: (1) a thick peripheral component encompassing the SPBC; and (2) a thin central component comprised predominantly of the radiologic ZPC. By manipulating the 3-D model, the varying appearances of the CML are displayed. High-resolution CT coupled with histopathology provides elucidation of the morphology of the CML, a strong indicator of infant abuse. This new information may prove useful in assessing the biomechanical factors that produce this strong indicator of abusive assaults in infants. (orig.)

  2. Deus: metafísica e pensar pós-metafísico (God: metaphysics and post-metaphysical thinking - DOI: 10.5752/P.2175-5841.2010v8n16p8

    Directory of Open Access Journals (Sweden)

    Ibraim Vitor de Oliveira

    2010-04-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Editorial - Dossiê: Pensamento pós-metafísico e discurso sobre Deus – (Dossier: Post-metaphysical thought and speech about God Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Deus: metafísica e pensar pós-metafísico (God: metaphysics and post-metaphysical thinking - DOI: 10.5752/P.2175-5841.2010v8n16p8 

  3. Long-term treatment with alendronate increases the surgical difficulty during simple exodontias – an in vivo observation in Holtzman rats

    Directory of Open Access Journals (Sweden)

    Conte-Neto Nicolau

    2012-07-01

    Full Text Available Abstract Background Atraumatic teeth extractions protocols are highly encouraged in patients taking bisphosphonates (Bps to reduce surgical trauma and, consequently, the risk of jaws osteonecrosis development. In this way, this paper aims to report the findings of increased surgical difficulty during simple exodontias in animals treated with bisphosphonates. Methods Sixty male Holtzman rats were randomly distributed into three groups of 20 animals and received daily subcutaneous administration of 1 mg/kg (AL1 or 3 mg/kg (AL3 of alendronate or saline solution (CTL. After 60 days of drug therapy all animals were submitted to first lower molars extractions under general anesthesia. Operatory surgical time and the frequency of teeth fractures were measured as principal outcomes and indicators of surgical difficulty degree. Results Animals treated with alendronate (AL1 and AL3 were associated to higher operatory times and increased frequency of teeth fractures compared to match controls. Conclusions The bisphosphonate therapy may be associated with an increased surgical difficulty and trauma following simple exodontias protocols, which is considered a critical issue when it comes to osteonecrosis development.

  4. Critique of metaphysics, capital logic and totality, and social critique theory: the three critical dimensions of Marx's philosophy

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Karl Marx's philosophy includes three dimensions of critique.The first is the critique of metaphysics,which is also the major premise on the basis of which Marx turns his philosophical viewpoint to the analysis of social life and its cultural logic.The second is the capital logic and totality,the core of Marx's philosophy,according to which Marx exposes the totality and contradictions inherent in the capital logic.The third is the theory of social critique that is the realistic end of his philosophy.

  5. Science Awareness and Science Literacy through the Basic Physics Course: Physics with a bit of Metaphysics?

    Science.gov (United States)

    Rusli, Aloysius

    2016-08-01

    Until the 1980s, it is well known and practiced in Indonesian Basic Physics courses, to present physics by its effective technicalities: The ideally elastic spring, the pulley and moving blocks, the thermodynamics of ideal engine models, theoretical electrostatics and electrodynamics with model capacitors and inductors, wave behavior and its various superpositions, and hopefully closed with a modern physics description. A different approach was then also experimented with, using the Hobson and Moore texts, stressing the alternative aim of fostering awareness, not just mastery, of science and the scientific method. This is hypothesized to be more in line with the changed attitude of the so-called Millenials cohort who are less attentive if not interested, and are more used to multi-tasking which suits their shorter span of attention. The upside is increased awareness of science and the scientific method. The downside is that they are getting less experience of the scientific method which intensely bases itself on critical observation, analytic thinking to set up conclusions or hypotheses, and checking consistency of the hypotheses with measured data. Another aspect is recognition that the human person encompasses both the reasoning capacity and the mental- spiritual-cultural capacity. This is considered essential, as the world grows even smaller due to increased communication capacity, causing strong interactions, nonlinear effects, and showing that value systems become more challenging and challenged due to physics / science and its cosmology, which is successfully based on the scientific method. So students should be made aware of the common basis of these two capacities: the assumptions, the reasoning capacity and the consistency assumption. This shows that the limits of science are their set of basic quantifiable assumptions, and the limits of the mental-spiritual-cultural aspects of life are their set of basic metaphysical (non-quantifiable) assumptions. The

  6. The hydrogen sulfide donor, Lawesson's reagent, prevents alendronate-induced gastric damage in rats

    International Nuclear Information System (INIS)

    Our objective was to investigate the protective effect of Lawesson's reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson's reagent (3, 9, or 27 µmol/kg, po) once daily for 4 days. After 30 min, gastric damage was induced by ALD (30 mg/kg) administration by gavage. On the last day of treatment, the animals were killed 4 h after ALD administration. Gastric lesions were measured using a computer planimetry program, and gastric corpus pieces were assayed for malondialdehyde (MDA), glutathione (GSH), proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-1β], and myeloperoxidase (MPO). Other groups were pretreated with glibenclamide (5 mg/kg, ip) or with glibenclamide (5 mg/kg, ip)+diazoxide (3 mg/kg, ip). After 1 h, 27 µmol/kg Lawesson's reagent was administered. After 30 min, 30 mg/kg ALD was administered. ALD caused gastric damage (63.35±9.8 mm2); increased levels of TNF-α, IL-1β, and MDA (2311±302.3 pg/mL, 901.9±106.2 pg/mL, 121.1±4.3 nmol/g, respectively); increased MPO activity (26.1±3.8 U/mg); and reduced GSH levels (180.3±21.9 µg/g). ALD also increased cystathionine-γ-lyase immunoreactivity in the gastric mucosa. Pretreatment with Lawesson's reagent (27 µmol/kg) attenuated ALD-mediated gastric damage (15.77±5.3 mm2); reduced TNF-α, IL-1β, and MDA formation (1502±150.2 pg/mL, 632.3±43.4 pg/mL, 78.4±7.6 nmol/g, respectively); lowered MPO activity (11.7±2.8 U/mg); and increased the level of GSH in the gastric tissue (397.9±40.2 µg/g). Glibenclamide alone reversed the gastric protective effect of Lawesson's reagent. However, glibenclamide plus diazoxide did not alter the effects of Lawesson's reagent. Our results suggest that Lawesson's reagent plays a protective role against ALD-induced gastric damage through mechanisms that depend at least in part on activation of ATP-sensitive potassium (KATP) channels

  7. The hydrogen sulfide donor, Lawesson's reagent, prevents alendronate-induced gastric damage in rats

    Energy Technology Data Exchange (ETDEWEB)

    Nicolau, L.A.D. [Núcleo de Pesquisa em Produtos Naturais, Departamento de Farmacologia, Universidade Federal do Piauí, Teresina, PI (Brazil); Silva, R.O.; Damasceno, S.R.B.; Carvalho, N.S.; Costa, N.R.D. [Laboratório de Fisiofarmacologia Experimental, Centro de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, Parnaíba, PI (Brazil); Aragão, K.S. [Laboratório de Farmacologia da Inflamação e do Câncer, Departamento de Farmacologia, Universidade Federal do Ceará, Fortaleza, CE (Brazil); Barbosa, A.L.R. [Núcleo de Pesquisa em Produtos Naturais, Departamento de Farmacologia, Universidade Federal do Piauí, Teresina, PI (Brazil); Laboratório de Fisiofarmacologia Experimental, Centro de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, Parnaíba, PI (Brazil); Soares, P.M.G.; Souza, M.H.L.P. [Laboratório de Farmacologia da Inflamação e do Câncer, Departamento de Farmacologia, Universidade Federal do Ceará, Fortaleza, CE (Brazil); Medeiros, J.V.R. [Núcleo de Pesquisa em Produtos Naturais, Departamento de Farmacologia, Universidade Federal do Piauí, Teresina, PI (Brazil); Laboratório de Fisiofarmacologia Experimental, Centro de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, Parnaíba, PI (Brazil)

    2013-08-16

    Our objective was to investigate the protective effect of Lawesson's reagent, an H{sub 2}S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson's reagent (3, 9, or 27 µmol/kg, po) once daily for 4 days. After 30 min, gastric damage was induced by ALD (30 mg/kg) administration by gavage. On the last day of treatment, the animals were killed 4 h after ALD administration. Gastric lesions were measured using a computer planimetry program, and gastric corpus pieces were assayed for malondialdehyde (MDA), glutathione (GSH), proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-1β], and myeloperoxidase (MPO). Other groups were pretreated with glibenclamide (5 mg/kg, ip) or with glibenclamide (5 mg/kg, ip)+diazoxide (3 mg/kg, ip). After 1 h, 27 µmol/kg Lawesson's reagent was administered. After 30 min, 30 mg/kg ALD was administered. ALD caused gastric damage (63.35±9.8 mm{sup 2}); increased levels of TNF-α, IL-1β, and MDA (2311±302.3 pg/mL, 901.9±106.2 pg/mL, 121.1±4.3 nmol/g, respectively); increased MPO activity (26.1±3.8 U/mg); and reduced GSH levels (180.3±21.9 µg/g). ALD also increased cystathionine-γ-lyase immunoreactivity in the gastric mucosa. Pretreatment with Lawesson's reagent (27 µmol/kg) attenuated ALD-mediated gastric damage (15.77±5.3 mm{sup 2}); reduced TNF-α, IL-1β, and MDA formation (1502±150.2 pg/mL, 632.3±43.4 pg/mL, 78.4±7.6 nmol/g, respectively); lowered MPO activity (11.7±2.8 U/mg); and increased the level of GSH in the gastric tissue (397.9±40.2 µg/g). Glibenclamide alone reversed the gastric protective effect of Lawesson's reagent. However, glibenclamide plus diazoxide did not alter the effects of Lawesson's reagent. Our results suggest that Lawesson's reagent plays a protective role against ALD-induced gastric damage through mechanisms that depend at least in part on activation of ATP-sensitive potassium (K

  8. Comment on Metaphysics in Teaching Practice%对教学实践中形而上学的评析

    Institute of Scientific and Technical Information of China (English)

    谌凤山

    2011-01-01

    Since the new curriculum reform,metaphysics has become relatively conspicuous in teaching practice.The main reason of its prevalence is either/or thoughts and flood of formalism,whose essence is ideological nihilism and behavioral socialism.In order to make the development of new curriculum reform healthy and harmonious,we need to understand comprehensively and solve metaphysical problem in teaching from the macro,mid and micro level.%新课改以来,形而上学在教学实践中表现得比较突出。其盛行的原因主要是非此即彼的绝对化思想和形式主义的泛滥,其本质是思想上的虚无主义和行为上的技术主义。为使新课改健康和谐的发展,需要我们从宏观、中观和微观层面全面认识并解决教学中的形而上学倾向。

  9. The old with the die. A contribution to metaphysics of quantum mechanics; Der Alte mit dem Wuerfel. Ein Beitrag zur Metaphysik der Quantenmechanik

    Energy Technology Data Exchange (ETDEWEB)

    Ijjas, Anna

    2011-07-01

    Since the rise of quantum mechanics also their ideological implications and consequences were discussed. Meanwhile still scarcely a metaphysical problem exists, which was not supposedly solved under calling on quantum theory. Anna Ijjas inquires the usual practice and developes a new model of the assignment of quantum mechanics and metaphysics. She discusses both the physical foundations and the classical philosophical controversies, before she draws consequencies for the relation determination of brain and consciousness, the problem of freedom of will, as well as for the question of the influence of God in the world.

  10. Retraction: 'Alendronate and vitamin D2 for prevention of hip fracture in Parkinson's disease: A randomized controlled trial,' by Sato, Y., Iwamoto, J., Kanoko, T., and Satoh, K.

    Science.gov (United States)

    2016-07-01

    The above article, published online on 14 March 2006 in Wiley Online Library (wileyonlinelibrary.com), and in Volume 21, Issue 7, Pages 924-929, has been retracted by agreement between the authors, the Editor-in-Chief, Jose A. Obeso, and Wiley Periodicals, Inc. The retraction has been agreed due to an acknowledgement from the authors that the co-authors did not participate in study design, data collection, data analysis, interpretation of data and drafting the manuscript. Thus all co-authors are honorary. Reference Sato, Y., Iwamoto, J., Kanoko, T., and Satoh, K. (2006) Alendronate and vitamin D2 for prevention of hip fracture in Parkinson's disease: A randomized controlled trial. Mov Disord. doi: 10.1002/mds.20825.

  11. Critica metafizicii şi noua retorică a liberalismului (The critics of metaphysics and the new rethoric of liberalism)

    OpenAIRE

    Mark BUCUCI

    2015-01-01

    During the Enlightment, the emergence and the prestige of sciences influenced the rhetoric of liberalism. This metaphysical rhetoric, according to Richard Rorty, became an ostacle to liberalism’ efficient marketing . Rorty deconstructs this rhetorical fusion and conceives a new kind of rhetoric for liberalism.

  12. Critica metafizicii şi noua retorică a liberalismului (The critics of metaphysics and the new rethoric of liberalism

    Directory of Open Access Journals (Sweden)

    Mark BUCUCI

    2015-03-01

    Full Text Available During the Enlightment, the emergence and the prestige of sciences influenced the rhetoric of liberalism. This metaphysical rhetoric, according to Richard Rorty, became an ostacle to liberalism’ efficient marketing . Rorty deconstructs this rhetorical fusion and conceives a new kind of rhetoric for liberalism.

  13. Changes in strain patterns after implantation of a short stem with metaphyseal anchorage compared to a standard stem: an experimental study in synthetic bone

    Directory of Open Access Journals (Sweden)

    Jens Gronewold

    2014-03-01

    Full Text Available Short stem hip arthroplasties with predominantly metaphyseal fixation, such as the METHA® stem (Aesculap, Tuttlingen, Germany, are recommended because they are presumed to allow a more physiologic load transfer and thus a reduction of stress-shielding. However, the hypothesized metaphyseal anchorage associated with the aforementioned benefits still needs to be verified. Therefore, the METHA short stem and the Bicontact® standard stem (Aesculap, Tuttlingen, Germany were tested biomechanically in synthetic femora while strain gauges monitored their corresponding strain patterns. For the METHA stem, the strains in all tested locations including the region of the calcar (87% of the non-implanted femur were similar to conditions of synthetic bone without implanted stem. The Bicontact stem showed approximately the level of strain of the non-implanted femur on the lateral and medial aspect in the proximal diaphysis of the femur. On the anterior and posterior aspect of the proximal metaphysis the strains reached averages of 78% and 87% of the non-implanted femur, respectively. This study revealed primary metaphyseal anchorage of the METHA short stem, as opposed to a metaphyseal-diaphyseal anchorage of the Bicontact stem.

  14. The Collision of Language and Metaphysics in the Search for Self-Identity: on ahamkara and asmita in Samkhya-Yoga

    Directory of Open Access Journals (Sweden)

    Marzenna JAKUBCZAK

    2014-07-01

    Full Text Available The author of this paper discusses some major points vital for two classical Indian schools of philosophy: (1 a significant feature of linguistic analysis in the Yoga tradition; (2 the role of the religious practice (iśvara-pranidhana in the search for true self-identity in Samkhya and Yoga darśanas with special reference to their gnoseological purposes; and (3 some possible readings of ‘ahamkara’ and ‘asmita’ displayed in the context of Samkhya-Yoga phenomenology and metaphysics. The collision of language and metaphysics refers to the risk of paralogism caused by the common linguistic procedures making the subject define its identity within the semantic order (i.e. verbal conventions and grammatical rules which does not reflect the actual metaphysical situation of the self, though it determines one’s self-understanding in the empirical sense. Whereas, Samkhya-Yoga aims at recognizing, reorganizing and, finally, going beyond these procedures regarded as the obstacles on the path towards self-knowledge and liberation form metaphysical ignorance.

  15. 刺向神秘主义和形而上学独断论的双刃剑%An Attack at Both Mysterious Necromancy and Metaphysical Dogmatism

    Institute of Scientific and Technical Information of China (English)

    赵林

    2009-01-01

    In Dreams of a Spirit-seer Explained through the Dreams of Metaphysics, a long treatise written by Kant in his pre-critical period, he did not only attack mysterious necromancy and metaphysical dogmatism on the basis of empirical experience, but also differentiated between metaphysics in the positive sense and metaphysics in the negative sense, and gave the first expression to the important ideas of limitations of reason and moral faith that later became the substantial content of Kantian critical philosophy. In this sense, this book marks Kant's departure from Wolff's school.%是康德早年所写的一篇长篇论文.在该文中,康德不仅以经验为根据,对神秘主义通灵术和形而上学独断论进行了深刻的批判,而且对形而上学的积极意义和消极意义进行了区分,初步表达了关于理性的界限和道德的信仰等重要思想,这些思想后来构成了康德批判哲学的基本内容.

  16. Metaphyseal osteomyelitis in children: how often does MRI-documented joint effusion or epiphyseal extension of edema indicate coexisting septic arthritis?

    International Nuclear Information System (INIS)

    Joint effusions identified by MRI may accompany osteomyelitis and determining whether the joint effusion is septic or reactive has important implications on patient care. Determine the incidence of epiphyseal marrow edema, joint effusions, perisynovial edema and epiphyseal non-enhancement in the setting of pediatric metaphyseal osteomyelitis and whether this may be used to predict coexisting septic arthritis. Following IRB approval, we retrospectively evaluated children who underwent MRI and orthopedic surgical consultation for suspected musculoskeletal infection between January 2011 and September 2013. Criteria for inclusion in the study were microbiologically/pathologically proven infection, MRI prior to surgical intervention, long bone involvement and age 0-18 years. MRI exams were independently reviewed by two faculty pediatric radiologists to confirm the presence of appendicular metaphyseal osteomyelitis, to evaluate extent of edema, to determine subjective presence of a joint effusion and to assess perisynovial edema and epiphyseal non-enhancement. Any discrepant readings were reviewed in consensus. Charts and operative notes were reviewed to confirm the diagnosis of osteomyelitis and septic arthritis. One hundred and three joints with metaphyseal osteomyelitis were identified (mean age: 7.1 years; M:F 1.3:1), of whom 53% (55/103) had joint effusions, and of those, 75% (41/55) had surgically confirmed septic arthritis. The incidence of coexisting septic arthritis was 40% in the setting of epiphyseal edema, 74% in epiphyseal edema and effusion, 75% with perisynovial edema, 76% with epiphyseal non-enhancement and 77% when all four variables were present. Of these, the only statistically significant variable, however, was the presence of a joint effusion with a P-value of <0.0001 via Fisher exact test. Statistical significance for coexisting septic arthritis was also encountered when cases were subdivided into intra-articular vs. extra-articular metaphyses (P

  17. Metaphyseal osteomyelitis in children: how often does MRI-documented joint effusion or epiphyseal extension of edema indicate coexisting septic arthritis?

    Energy Technology Data Exchange (ETDEWEB)

    Schallert, Erica K.; Kan, J.H.; Monsalve, Johanna; Zhang, Wei; Bisset, George S. [Texas Children' s Hospital, Department of Pediatric Radiology, Houston, TX (United States); Rosenfeld, Scott [Texas Children' s Hospital, Department of Pediatric Orthopedic Surgery, Houston, TX (United States)

    2015-08-15

    Joint effusions identified by MRI may accompany osteomyelitis and determining whether the joint effusion is septic or reactive has important implications on patient care. Determine the incidence of epiphyseal marrow edema, joint effusions, perisynovial edema and epiphyseal non-enhancement in the setting of pediatric metaphyseal osteomyelitis and whether this may be used to predict coexisting septic arthritis. Following IRB approval, we retrospectively evaluated children who underwent MRI and orthopedic surgical consultation for suspected musculoskeletal infection between January 2011 and September 2013. Criteria for inclusion in the study were microbiologically/pathologically proven infection, MRI prior to surgical intervention, long bone involvement and age 0-18 years. MRI exams were independently reviewed by two faculty pediatric radiologists to confirm the presence of appendicular metaphyseal osteomyelitis, to evaluate extent of edema, to determine subjective presence of a joint effusion and to assess perisynovial edema and epiphyseal non-enhancement. Any discrepant readings were reviewed in consensus. Charts and operative notes were reviewed to confirm the diagnosis of osteomyelitis and septic arthritis. One hundred and three joints with metaphyseal osteomyelitis were identified (mean age: 7.1 years; M:F 1.3:1), of whom 53% (55/103) had joint effusions, and of those, 75% (41/55) had surgically confirmed septic arthritis. The incidence of coexisting septic arthritis was 40% in the setting of epiphyseal edema, 74% in epiphyseal edema and effusion, 75% with perisynovial edema, 76% with epiphyseal non-enhancement and 77% when all four variables were present. Of these, the only statistically significant variable, however, was the presence of a joint effusion with a P-value of <0.0001 via Fisher exact test. Statistical significance for coexisting septic arthritis was also encountered when cases were subdivided into intra-articular vs. extra-articular metaphyses (P

  18. 阿仑膦酸钠对绝经后骨质疏松性骨痛的疗效分析%Effect analysis of alendronate on postmenopausal osteoporosis with bone ache

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ Background: Osteoporosis is a metabolic bone disease characterized by low bone component and regeneration of the microstructure of bone tissues, osteoporosis occurs in postmenopausal women for decreased estrogen level. Those women with osteoporosis often suffer from bone ache, such as pain at low back, back, knees and heels. In severe cases, there may be crookback or non- violent fracture. Objective: To discuss treatment effect of the Alendronate on 56 postmenopausal women with bone ache caused by osteoporosis. Unit: 210 Hospital of PLA.

  19. Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis

    Directory of Open Access Journals (Sweden)

    Jun Iwamoto

    2009-07-01

    Full Text Available Jun Iwamoto1, Mitsuyoshi Uzawa2, Yoshihiro Sato3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, Japan; 3Department of Neurology, Mitate Hospital, Fukuoka, Japan Abstract: The antiresorptive drug elcatonin (ECT is known to relieve pain in postmenopausal women with osteoporosis. A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN and ECT on bone mineral density (BMD and bone turnover with those of single treatment with ALN in postmenopausal women with osteoporosis. Two hundred and five postmenopausal osteoporotic women (mean age: 70 years were recruited in our outpatient clinic. Forty-six women with back pain were treated with ALN and ECT (intramuscular, 20 units a week, and 159 women without obvious back pain were treated with ALN alone. The lumbar BMD, urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX, and serum levels of alkaline phosphatase (ALP were measured during the six-month treatment period. The baseline characteristics, except for age, body weight and number of patients with prevalent vertebral fractures, were not significantly different between the two groups. The mean increase rate in the lumbar BMD at six months was similar in the ALN (+4.41% and ALN+ECT (+5.15% groups, following similar reduction rates in urinary NTX levels (-40.2% and -43.0%, respectively, at three months and serum ALP levels (-19.0% and -19.7%, respectively, at six months. These results were consistent even after adjustments for age, body weight, and number of patients with prevalent vertebral fractures. The present study in postmenopausal osteoporotic women confirmed that the effects of short-term combined treatment with ALN and ECT on lumbar BMD and bone turnover in patients with back pain appeared to be

  20. 涉江而过--形而下、形而上解构说课比赛%Wade through the River-Physical, Metaphysical Deconstruction Lessons Game

    Institute of Scientific and Technical Information of China (English)

    王琳

    2015-01-01

    近年来,说课以其具备教学一体化、提高教研活动实效、系统全面地梳理教学过程等优点,在全国以竞赛的形式受到广泛推崇。用“涉江而过”作为本论文的主题,除传达一种竞赛的态度与现状外,更多是针对教师对说课知识的拆分、重组认知与说课情感层次梳理的能力而言。好的说课标准,不仅需要有机械解构组合的能力,还必然包含课堂温度创设的智慧。换言之,它应该是形而下的理性组成形式+形而上的感性提炼内核,二者相辅相成的处理方法则是贯穿始终的主线。在本文中,笔者另辟蹊径以自身的经历、经验对说课做了全新切入角度的诠释。%In recent years, lessons as its integration with teaching and improve the effectiveness of teaching and research ac-tivities, teaching full advantage carding process and other systems in the country in the form of the contest was widely re-spected. With the"River of it off"as the theme of this paper, in addition to the status quo attitude and convey a contest, more knowledge is split Lessons, cognitive restructuring and emotional level Lessons for teachers in terms of the ability to sort out. Lessons good standard, not only have the ability to deconstruct a combination of mechanical, but also must contain the wis-dom of creating classroom temperature. In other words, it should be composed in the form of a physical+rational metaphys-ical sensibility refined kernel approach is both complementary to the main line runs through. In this article, the author com-bined with his own experience to explain lessons from a new interpretation.

  1. Metafizinės patirtys Gražinos Cieškaitės lyrikoje | Metaphysical Experiences in Gražina Cieškaitė’s poetry

    Directory of Open Access Journals (Sweden)

    Audinga Peluritytė

    2005-01-01

    Full Text Available This paper analyses and discusses the signs of metaphysical experience in the work of the contemporary Lithuanian poetess Gražina Cieškaitė. The paper was inspired by Vytautas Kavolis’ provoking thought that in Cieškaitė’s poetry attempt is made to analyse and criticise the key myths of Western civilisation, and female mythology, very old and going back to pre-civilisation conscience, is recreated from the shards of the broken myth of Western civilisation. In this paper, Cieškaitė’s work is analysed in several stages that are reflected in the headlines of the sections. Recognisable are the landmarks of metaphysical thinking, mythical personages and plots; discussed are the outcomes of the interaction of eclectic metaphysical and mythical thinking; finally, an attempt is made at recognising the central idea of this metaphysical lyric and at reconstructing the version of myth so closely linked with this idea. All parts of the paper are concerned with the issue of poetic language, and the key features of Cieškaitė’s poetics are recorded. The paper asserts that in Cieškaitė’s work it is really possible to restore an extremely old version of female mythology, which is embodied in the figure of the goddess Aphrodite that had acquired Promethean creative powers. Yet here metaphysical experiences can hardly be generalised as one comprehensive metaphysical theory. In Cieškaitė’s work, metaphysical thinking based on language and logic frequently yields ground to spontaneous mystical experiences, which are not controlled by either logic or language.

  2. O alendronato de sódio na prevenção da osteopenia secundária à imobilização gessada, em ratas: avaliação histomorfométrica Alendronate sodium to prevent osteopenia caused by cast immobilization in female rats: histomorphometric evaluation

    Directory of Open Access Journals (Sweden)

    José B. Volpon

    2008-10-01

    Full Text Available OBJETIVO: Analisar, por meio da histomorfometria, o efeito do alendronato de sódio sobre o trabeculado ósseo de ratos, quando administrado simultaneamente com imobilização gessada. MÉTODOS: Foram utilizados quatro grupos com cinco fêmeas de ratos Wistar: 1 imobilizado; 2 não imobilizado + alendronato; 3 imobilizado + alendronato; e 4 controle. A imobilização foi feita com gesso pelvipodálico aplicado até o membro posterior direito e o alendronato foi administrado em doses semanais. O período de observação foi de 28 dias e realizada histomorfometria da metáfise proximal da tíbia, com análise do número de trabéculas, volume ósseo, espessura trabecular e separação trabecular. RESULTADOS: O grupo imobilizado apresentou volume ósseo menor que os demais grupos. Os animais que receberam alendronato semanal, tanto imobilizados, quanto não imobilizados, apresentaram volume ósseo maior que o controle. A espessura trabecular no grupo imobilizado foi menor do que nos grupos controle e não imobilizado que recebeu alendronato, mas não apresentou diferença significativa em relação ao imobilizado com alendronato. O grupo imobilizado apresentou separação trabecular maior que os demais grupos. Os grupos não imobilizado, sem imobilização que recebeu alendronato e imobilizado que recebeu alendronato apresentaram aumento no número de trabéculas em relação ao grupo imobilizado. CONCLUSÃO: A imobilização empregada efetivamente levou à osteopenia, verificada pela diminuição de todos os principais parâmetros histomorfométricos estudados. Estas alterações foram prevenidas pela administração concomitante de alendronato sódico, exceto com relação à espessura trabecular. O alendronato de sódio foi capaz de aumentar os parâmetros morfométricos, mesmo em animais não imobilizados.OBJECTIVE: Using histomorphometric means to analyze the effect of alendronate sodium on the bone trabeculate of rats administered

  3. 阿伦膦酸钠治疗绝经后骨质疏松症的疗效观察%Effects of alendronate on postmenopausal osteoporosis

    Institute of Scientific and Technical Information of China (English)

    孙敬华; 徐晓峰; 迟晓飞; 王景靓

    2013-01-01

    目的观察阿伦膦酸钠对绝经后妇女原发性骨质疏松症的有效性和安全性。方法绝经后骨质疏松患者130例,将患者完全随机分成观察组及对照组,各65例。观察组每周口服阿伦膦酸钠70mg和元素钙(碳酸钙)及骨化醇;对照组口服元素钙(碳酸钙)及骨化醇。疗程均为12个月;通过骨密度仪观察治疗前及治疗后的骨密度的变化。结果治疗12个月后,观察组L2~4和股骨颈平均骨密度明显高于治疗前和对照组治疗后[L2~4:(844±116)mg/cm3比(788±76)mg/cm3、(785±64)mg/cm3;股骨颈:(681±71)mg/cm3比(644±72)mg/cm3、(662±90)mg/cm3],差异均有统计学意义(P<0.05或P<0.01)。治疗过程中未发现与药物有关的不良反应。结论阿伦膦酸钠治疗绝经后骨质疏松症有效且安全。%Objective To determine the efficiency and safety of alendronate on primary osteoporosis in postmenopausal women. Methods One hundred and thirty cases of postmenopausal women with osteoporosis were randomly divided into 2 group(control group and treatment group). All subjects in treatment group received alendronate 70 mg weekly.All patients received supplemental calcium and alfacalcidol orally daily for 12 months . Results Bone mineral density of L2~4 and femur neck in treatment group after treatment for 12 months were more than those before treatment and those in control group after treatment for 12 months[L2~4:(844±116)mg/cm3、(788±76)mg/cm3、(785±64)mg/cm3;neck of femur:(681±71)mg/cm3、(644±72)mg/cm3、(662±90)mg/cm3] and there were significant differences(P<0.05 or P<0.01). During treatment, drug related adverse reactions were occurred. Conclusion Alendonate is well effective and safe at doses of 70 mg weekly in the treatment of primary osteoporosis in postmenopausal women.

  4. Potency of a combined alfacalcidol-alendronate therapy to reduce the risk of falls and fractures in elderly patients with glucocorticoid-induced osteoporosis.

    Science.gov (United States)

    Ringe, Johann D; Schacht, Erich; Dukas, Laurent; Mazor, Ze'ev

    2011-01-01

    This is a preplanned subgroup analysis on 318 patients with glucocorticoid-induced osteoporosis (GIOP) from an open, prospective, multi-centered, uncontrolled study on a large cohort of elderly patients with a high risk of falls and fractures. The entire group of 2579 patients was recruited by 818 practicing physicians and treated for three months with a new combination package containing 4 or 12 self-explanatory one-week blisters, each with one tablet of 70 mg alendronate (CAS 260055-05-8) and 7 capsules of 1 pg alfacalcidol (CAS 41294-56-8) (Tevabone"). The average age of the GIOP patients was 71 years and the mean body mass index 26.7 kg/m2. 58% had a diagnosis of increased risk of falls, prevalent vertebral and non-vertebral fractures were documented in 70% and 65% of the patients, respectively, and a creatinine clearance (CrCl) below 65 ml/min was documented in 55 %. Main outcome parameters were the Chair Rising Test (CRT), Timed Up and Go Test (TUG), back pain and safety at onset and after 3 months. In addition, an evaluation of the package design was done at the end of the study. The percentage of patients able to perform the CRT within 10 sec increased from 21.1% to 39.4% after 3 months (increase 87%, p sec increased by 84% (p sec (p = 0.0025) (difference of 1.9 sec) and for the TUG the mean time decreased from 16.86 sec to 14.64 sec (p = 0.0056) (difference of 2.2 sec). Mean back pain measured by a 0-10 visual analogue scale decreased significantly by 43% from 6.0 to 3.4 (p compliance. This may contribute to the previously shown significant effect on reducing falls and fractures with the same regimen during a controlled long-term trial in primary osteoporosis. PMID:21428245

  5. Pharmacodynamic responses to combined treatment regimens with the calcium sensing receptor antagonist JTT-305/MK-5442 and alendronate in osteopenic ovariectomized rats.

    Science.gov (United States)

    Fisher, John E; Scott, Kevin; Wei, Nan; Zhao, Jing Z; Cusick, Tara; Tijerina, Monica; Karanam, Bindhu; Duong, Le; Glantschnig, Helmut

    2012-06-01

    Parathyroid hormone (PTH) is the anabolic standard of care for patients with severe osteoporosis. The CaSR allosteric antagonist JTT-305/MK-5442, a PTH secretagogue, could offer an oral osteoanabolic treatment alternative for postmenopausal women with osteoporosis. Here we disclose the pharmacokinetic profile of JTT-305/MK-5442 and its activity on bone remodeling in ovariectomized (OVX) osteopenic rats. Daily treatments (0.3 to 2.4 mg/kg/d) for 12 weeks resulted in plateaued BMD increases (3.8 to 5.3%) at axial and appendicular skeletal sites. However, treatment effects were not statistically significant, in agreement with effects seen in animals treated with low dose PTH (1-84) (5 μg/kg/d). In a consecutive study we tested JTT-305/MK-5442 effects on bone formation in OVX-rats challenged with combined alendronate (ALN) treatment paradigms. At 7 month, JTT-305/MK-5442 treatment significantly increased BMD in lumbar vertebrae (LV), while no change in BMD was observed in femora or tibiae. ALN add-on co-treatment produced incremental increases in LV, distal femur (DF) and proximal tibia (PT) BMD over the respective ALN control. Histological analyses confirmed modest increases in mineralized surface (MS/BS) and bone formation rate (30.5±1.9%) on trabecular surfaces by JTT-305/MK-5442. As expected, ALN administration profoundly reduced bone formation, however, JTT-305/MK-5442 significantly stimulated MS/BS and BFR in ALN treated groups. In summary, JTT-305/MK-5442 acts as a PTH secretagogue in the osteopenic OVX-rat, eliciting consistent, though modest effects on remediation of BMD due to estrogen depletion. Induction of bone formation by JTT-305/MK-5442 at trabecular bone surfaces appears to be resilient to ALN-mediated suppression of bone formation. This study provides for the first time, a mechanistic evaluation of combination treatment of a PTH secretagogue with ALN.

  6. Persistence of 1,25D-induced hypercalciuria in alendronate-treated genetic hypercalciuric stone-forming rats fed a low-calcium diet.

    Science.gov (United States)

    Frick, Kevin K; Asplin, John R; Culbertson, Christopher D; Granja, Ignacio; Krieger, Nancy S; Bushinsky, David A

    2014-05-01

    Genetic hypercalciuric stone-forming (GHS) rats demonstrate increased intestinal Ca absorption, increased bone resorption, and reduced renal tubular Ca reabsorption leading to hypercalciuria and all form kidney stones. GHS have increased vitamin D receptors (VDR) at these sites of Ca transport. Injection of 1,25(OH)2D3 (1,25D) leads to a greater increase in urine (u)Ca in GHS than in control Sprague-Dawley (SD), possibly due to the additional VDR. In GHS the increased uCa persists on a low-Ca diet (LCD) suggesting enhanced bone resorption. We tested the hypothesis that LCD, coupled to inhibition of bone resorption by alendronate (alen), would eliminate the enhanced 1,25D-induced hypercalciuria in GHS. SD and GHS were fed LCD and half were injected daily with 1,25D. After 8 days all were also given alen until euthanasia at day 16. At 8 days, 1,25D increased uCa in SD and to a greater extent in GHS. At 16 days, alen eliminated the 1,25D-induced increase in uCa in SD. However, in GHS alen decreased, but did not eliminate, the 1,25D-induced hypercalciuria, suggesting maximal alen cannot completely prevent the 1,25D-induced bone resorption in GHS, perhaps due to increased VDR. There was no consistent effect on mRNA expression of renal transcellular or paracellular Ca transporters. Urine CaP and CaOx supersaturation (SS) increased with 1,25D alone in both SD and GHS. Alen eliminated the increase in CaP SS in SD but not in GHS. If these results are confirmed in humans with IH, the use of bisphosphonates, such as alen, may not prevent the decreased bone density observed in these patients. PMID:24573387

  7. A Review on Study of Max Horkheimer 's Metaphysics Critique%霍克海默形而上学批判研究述评

    Institute of Scientific and Technical Information of China (English)

    李晓培

    2014-01-01

    As far as the study about metaphysics critical of Max Horkheimer is concerned , researches still stay in the preliminary stage , focusing on the study of Horkheimer's critique of positivism , the features and the origin of his critical the-ory, and the dilemma of his critical theory ,etc..But Max Horkheimer's thinking about the metaphysics critique is randomly reflected in the texts of these studies .By combing scholars'views, It can be found that the metaphysics critique of Max Horkheimer is the authentic origin of Critical Theory .%国内外学界对霍克海默形而上学批判的研究不系统,研究领域主要集中在关于霍克海默对实证主义的批判研究、关于霍克海默批判理论的特色研究、关于霍克海默批判理论的理论来源研究以及关于霍克海默批判理论的困境等方面,而关于霍克海默形而上学批判思想零星地反映在这些研究的文本中。通过梳理国内外学者的观点可以发现,霍克海默形而上学批判思想是其构建批判理论的真正发源地。

  8. Effect of weight-bearing exercise and calcium supplement on cortical and trabecular bone in the proximal tibia metaphyseal- an experimental protocol in ovariectomized rats

    Directory of Open Access Journals (Sweden)

    Valliollah Dabidy Roshan1

    2009-01-01

    Full Text Available (Received 4 April, 2009; Accepted 17 June, 2009AbstractBackground and purpose: Osteoporotic fractures are much more common in older post-menopausal women and account for significant morbidity and mortality. Although age is an independent risk factor for fractures, bone micro-architecture is the predictor of subsequent fractures. Adequate calcium and Weight-bearing exercise are known to affect skeletal development, however, the effects of calcium supplement and treadmill endurance running on bone micro-architecture are not well known. The objective of this study was to determine the effects of treadmill endurance running training and calcium supplement, on micro-architectures of cortical and trabecular bone in the proximal tibia metaphyseal in ovariectomized Sprague Dawley rats.Materials and methods: Forty-three rats were randomly divided into endurance running training, calcium supplement, control, pre-test and base groups. The rats in the treadmill running group performed the progressive running exercise in 12 to 20 m/minutes for a total of 10 to 60 minutes, 5 times a week. Calcium group received ca supplement using Gavage (35 mg/kg/day for 8 weeks. After 8 weeks, micro-architecture parameters in the proximal tibia metaphyseal were measured by using a semi-automated image analysis system.Results: The ovariectomay was associated with a significant decrease in the trabecular volume and thickness, while separation insignificantly decreased in the cortical volume and thickness in the proximal tibia metaphyseal. The treadmill running exercise and calcium supplement significantly increased cortical or trabecular volume and also thickness and the trabecular separation compared with age-matched controls. Furthermore, the micro-architectures of cortical and trabecular bone in the proximal tibia metaphyseal was insignificant between the treadmill endurance running and calcium supplement groups.Conclusion: Skeletal benefits can be obtained by changes in

  9. Melt-metaphyseal and diphyseal osteotomy for correction of infantile Blount’s disease: a long-term follow-up study

    OpenAIRE

    Liu, Jie; Cao, Lei; Guo, Shi-Fang; Xue, Wen; Chen, Zhi-Xin; Tai, Hui-Ping; He, Zong-Ru; Qian, Yao-Wen

    2015-01-01

    Blount’s disease is an uncommon disorder of postero-medial proximal tibial physis. Blount described infantile and adolescent types. This study aims to describe using femur, tibia and fibula osteotomies to treat infantile Blount’s disease. From May 1992 to May 2005, 7 patients of Blount’s disease (3 males, 4 females) were included, whose age was range from 17 to 62 months. Femorotibial angle (FTA) was 31 ± 6° (range from 27° to 41°). Metaphyseal-diaphyseal angle (MDA) was 16 ± 4° (range from 1...

  10. The space, the solitude and the simulacrum: the metaphysicals trajectories in the Italian’s narrative in the 20th century

    Directory of Open Access Journals (Sweden)

    Andrea Santurbano

    2009-08-01

    Full Text Available This paper discusses, through the analysis of works of authors which Gadda, Savinio, Bontempelli, Buzzati and Morselli, an anti-realistic tendency, though multiform in its stylistic and thematic success, which can be identified in the Italian literature of the twentieth century. In a comparative perspective, in dialogue with the avant-garde art, and more specifically, with the metaphysical paintings of Giorgio de Chirico, seeks to reflect on some aspects of these narratives as spatial and symbolic elements, to the threshold of the genus (or mode fantastic metaforize and constitute a condition of existential concern.

  11. The Metaphysics of Time

    OpenAIRE

    m a; f Farhanian

    2012-01-01

    Time is one of the most difficult subjects in philosophy. Some philosophers believe that time is a reality and others assume it as an illusion. McTaggart has denied the reality of time. His argument is very famous in the philosophy of time and thus the recent discussions about time are affected by his argument. Events and moments, he thinks, can occur in time in two forms and thus there are two series of time: 1) A series in which two events and moments are ordered as past, present and fut...

  12. The Metaphysics of Time

    Directory of Open Access Journals (Sweden)

    m a

    2012-03-01

    Events and moments, he thinks, can occur in time in two forms and thus there are two series of time: 1 A series in which two events and moments are ordered as past, present and future, 2 B series in which the events and moments are ordered as a priori and a posterior. The A series is necessary for time because without A series time does not exist. At the same time, A series leads to contradiction and time cannot exist as a real thing. Only one real and non-temporal series, he believes, exists but it appears as time series to us by our perception.

  13. Metaphysics after Aquinas

    Directory of Open Access Journals (Sweden)

    Moses Aaron T. Angeles

    2007-12-01

    Full Text Available It is interesting to note that after the death of St. Thomas his mentor, St. Albert the Great, remarked that his student put up an end to everybody's labor, not only in their own time, but even right up to the end of time. This was reported to us by a certain Bartholomew of Capua, protonotary from the Kingdom of Sicily, who was a witness of St. Thomas' canonization process. After the sudden demise of Thomas, Albert, already advanced in age, has assumed the task of defending the integrity of his student as a theologian and philosopher. On his return to Cologne, he wanted that all the works of Thomas read to him in set order, and he concluded his encomia saying that "Brother Thomas had in his writings put an end to everybody's labors right up to the end of the world, and that from now on all further work would be without purpose." Certainly modern readers would question such an assertion. Now that every ideology and systems of thought are under the suspicious eyes of postmodern thinkers, care must be exercised in proclaiming something as final and definite. No wonder such a statement was rarely uttered even within the ranks of the Dominican Friars.

  14. The historical dimension of"The principle of moral metaphysics"%探析《道德形而上学原理》的历史维度

    Institute of Scientific and Technical Information of China (English)

    朱宏

    2014-01-01

    With the development of Chinese society, the moral after being abandoned for a long time, finally returns to the field of vision, gradually aroused people's attention. Then I will be in accordance with the principle of Kant's moral metaphysics, the essay discusses the time sequence of construction, and combined with the example of the development of the society and Kant. Hope to be able to deepen understanding of the principles of Kant's moral metaphysics, in order to have a new understanding.%随着中国社会的发展,道德在被抛弃良久之后,终于渐渐重回视野,引起了人们的重视。下面我将按照康德本人对于道德形而上学原理构建的时间顺序进行论述,并结合社会的当下发展与康德的文中例证加以论述。希望能够加深对于康德道德形而上学原理的理解,以求有新的认识。

  15. The Influence of Chinese Metaphysical Poetry on Neo-Confucian Poetry%论魏晋玄言诗对两宋理学诗的影响

    Institute of Scientific and Technical Information of China (English)

    王利民

    2015-01-01

    玄言诗以其崇义重理的特征深刻地影响了理学诗,并为理学诗奠定了基本的意义生成模式,即以诗化的议论阐释深邃的哲理,通过意象呈现情感和理智的融合,用玄境的构造传达悠远的理趣。玄言诗所具有的形上性、隐喻性和主体性,为理学诗同样特性的形成起到了发轫作用。“玄”和“理”的至上性和至善本质规定了玄言诗和理学诗的道德性,使二者具有鲜明的道德立场。根据述事、抒情和说理三种元素在诗中所占的地位和比例,可以将玄言诗划分为“但陈要妙”的玄理诗、“冥然玄会”的玄感诗和“超入玄境”的玄境诗。玄理诗是阐说义理之性理诗的先导,玄感诗是吟咏性情之理兴诗的前茅,玄境诗是表现意境之理趣诗的始基。理学诗风类似于玄言诗风的历史重演。在题材、类型的规定性上,玄言诗能对理学诗造成影响,主要是因为两者有着相似的体用思维模式。这种思维模式以理事不二、体用相即为思想基础,暗含着月映万川、理一分殊意识的萌芽。%Metaphysical poetry in the Wei and Jin Dynasties, characterized by its emphasis on philo-sophical thinking, profoundly affected Neo-Confucian poetry and laid the foundation for the way Neo-Confucian poetry expressed its philosophical themes. This mode of meaning generation has the following features:it used poetic comments to interpret profound philosophical meaning; created vivid images to present the fusion of emotion and rationality; and constructed metaphysical situations to convey rich philosophical flavor. Metaphysical, metaphorical and subjective in meaning and expression, metaphysi-cal poetry foreshadowed the emergence of Neo-Confucian poetry. The supremacy and perfectionism of“metaphysics” and “rationality” defined the moral pursuits of metaphysical poetry and Neo-Confucian poetry, enabling them to bear a clear moral

  16. Risk reduction of falls and fractures, reduction of back pain and safety in elderly high risk patients receiving combined therapy with alfacalcidol and alendronate: a prospective study.

    Science.gov (United States)

    Schacht, Erich; Ringe, Johann D

    2011-01-01

    Efficacy and safety of a new combination package containing 4 or 12 self-explanatory one-week blisters, each with one tablet of 70 mg alendronate (CAS 260055-05-8) and 7 capsules of 1 microg alfacalcidol (CAS 41294-56-8) (Tevabone) on muscle power, muscle function, balance and back pain was investigated in an open, multi-centered, uncontrolled, prospective study on a cohort of elderly patients with a high risk of falls and fractures. 818 practicing physicians all over Germany recruited 2579 patients for a 3-month observational trial being treated with the above combination package. 92.4% were women [89.7% of the women had postmenopausal osteoporosis (PMO)]. Their average age was 74.1 years and the mean body mass index 26.4 kg/m2. 55.4% had a history of falls. Prevalent vertebral and non-vertebral fractures were documented in 62.9% and 61.4% of the patients, respectively, and a creatinine clearance below 65 ml/min was documented in 65.5%. Main outcome parameters were the Chair Rising Test (CRT), Timed Up and Go Test (TUG), back pain and safety at onset and after 3 months. In addition an evaluation of the package design was done at the end of the study. The percentage of patients able to perform the CRT within 10 sec increased from 26.3% to 42.9% after 3 months (increase 63%, p sec of TUG increased by 54% (p sec (p sec (p sec in the performance of TUG results in a 24% increased risk for non-vertebral fractures. Mean back pain measured by a 0-10 visual analogue scale decreased significantly by 41% from 5.9 to 3.5 (p compliance. This may contribute to the previously shown significant effect on reducing falls and fractures with the same regimen during a controlled long-term trial. The same trend was found in all mentioned efficacy parameters and no different trend in safety in the large subgroup of 2106 women with documented PMO. PMID:21355445

  17. Effects of Daily or Cyclic Teriparatide on Bone Formation in the Iliac Crest in Women on No Prior Therapy and in Women on Alendronate.

    Science.gov (United States)

    Dempster, David W; Cosman, Felicia; Zhou, Hua; Nieves, Jeri W; Bostrom, Mathias; Lindsay, Robert

    2016-08-01

    There is little information on the effects of combination therapy for osteoporosis at the tissue level. Using quadruple tetracycline-labeled bone biopsies, we have compared the bone formation response to teriparatide (TPTD) in treatment-naïve subjects (Rx-Naïve) and in subjects on prior and ongoing alendronate (ALN) treatment (ALN-Rx). Three bone envelopes were analyzed: cancellous, endocortical, and intracortical. TPTD was given as a standard, continuous daily injection or as a cyclic regimen (3 months on daily TPTD, 3 months off, 3 months on daily TPTD). Subjects were biopsied at 7 weeks and at 7 months to allow comparison of the bone formation response to the first and second cycles of TPTD. Baseline values for dynamic bone formation indices were lower in ALN-Rx than Rx-Naïve subjects. Both Rx-Naïve and ALN-RX subjects responded to TPTD with significant increases in bone formation indices at both time points. With cyclic TPTD treatment, the first and second cycles of TPTD stimulated bone formation rate in the cancellous and endocortical envelopes to a similar extent in ALN-Rx and Rx-Naïve subjects. However, in Rx-Naïve patients, bone formation rate (BFR/BS) was higher in patients receiving daily treatment compared with those receiving cyclic TPTD treatment in all three envelopes in the 7-month biopsies. This suggests that the cyclic approach does not provide a skeletal benefit in treatment-naive patients. In the 7-month biopsies, cortical porosity was higher in the Rx-Naïve group receiving daily TPTD than in all other groups. These data provide supporting evidence at the tissue level for previous biochemical and densitometric data suggesting that addition of either cyclic or daily TPTD to ongoing ALN treatment may be an effective approach for patients with severe osteoporosis already treated with ALN who remain at high risk of fracture. © 2016 American Society for Bone and Mineral Research. PMID:26916877

  18. The Metaphysics of {D-CTCs}: On the Underlying Assumptions of {Deutsch}'s Quantum Solution to the Paradoxes of Time Travel

    CERN Document Server

    Dunlap, Lucas

    2015-01-01

    I argue that Deutsch's model for the behavior of systems traveling around closed timelike curves (CTCs) relies implicitly on a substantive metaphysical assumption. Deutsch is employing a version of quantum theory with a significantly supplemented ontology of parallel existent worlds, which differ in kind from the many worlds of the Everett interpretation. Standard Everett does not support the existence of multiple identical copies of the world, which the D-CTC model requires. This has been obscured because he often refers to the branching structure of Everett as a "multiverse'', and describes quantum interference by reference to parallel interacting definite worlds. But he admits that this is only an approximation to Everett. The D-CTC model, however, relies crucially on the existence of a multiverse of parallel interacting worlds. Since his model is supplemented by structures that go significantly beyond quantum theory, and play an ineliminable role in its predictions and explanations, it does not represent ...

  19. Zabójstwo jako akt metafizyczny. Na marginesie dramatu alberta Camusa 'Kaligula' (CRIME AS A METAPHYSICAL ACT. ABOUT ALBERT CAMUS' DRAMA 'CALIGULA'

    Directory of Open Access Journals (Sweden)

    Ireneusz Ziemiński

    2006-06-01

    Full Text Available The problem of the article is the possibility of a crime as such. The analysis of the Caligula's crime motivation presented by Camus leads to conclusion that Caligula used to kill his dependents not by political or psychological reasons (as revenge for his sister's death, frightening of his own death or desire for eternity. It was not also moral motivation (an attempt to confirm his freedom, to realize absolute evil or to call people for authentic life. The main Caligula's motivation is rather metaphysical experience of his sister's death showing the cruelty of gods (they make people to live only to put them to death. According to Caligula, his own crimes are only imitation of gods to show how cruel and nonhuman the order of world is. The conclusion is that the question about the possibility of crime is incorrect, because the crime is essential part of the order of world.

  20. 道德与自然:"形上之道"与"形而上学"的本质区别%Morality and nature:The essential difference between the Dao of Chinese philosophy and metaphysics in Western philosophy

    Institute of Scientific and Technical Information of China (English)

    余卫东; 徐瑾

    2009-01-01

    中国哲学的"形上之道"与西方哲学的"形而上学"都是对超经验的形上事物的研究,但是两者存在着根本的不可通约的区别:"形而上学"是着眼于从认识论求"真"的角度来研究的关于自然本体论的"知识",即"自然形而上学";而"形上之道"更多地表现为求"善"的内心体验式的对道德境界的追求和精神寄托,即"道德形而上学".产生区别的内在原因是传统西方以"主客两分"为特征的理性传统与传统中国以"天人合一"为特征的德性传统的不同.%Both thinkings on Dao in Chinese philosophy and metaphysics in Western philosophy investigate things on a spiritual level that transcends experience, but there are incommensurable differences between them. The objective of "metaphysics" is ontological knowledge about nature from the perspective of epistemological "truth-pursuing". Western metaphysics is thud a "metaphysics of nature". Dao in Chinese philosophy, on the other hand, more often manifests itself in "good-pursuing" by means of the internal, experiential pursuit of moral stature and spiritual security. Philosophy of Dao is thus a "metaphysics of ethics". The cause of this difference can be traced back to the differences between the rational tradition of the West, characterized by the dualism of the subject and the object, and the moral tradition of China, characterized by the integration of man and nature.

  1. Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: a head-to-head comparison with alendronate.

    Science.gov (United States)

    Williams, Donald S; McCracken, Paul J; Purcell, Mona; Pickarski, Maureen; Mathers, Parker D; Savitz, Alan T; Szumiloski, John; Jayakar, Richa Y; Somayajula, Sangeetha; Krause, Stephen; Brown, Keenan; Winkelmann, Christopher T; Scott, Boyd B; Cook, Lynn; Motzel, Sherri L; Hargreaves, Richard; Evelhoch, Jeffrey L; Cabal, Antonio; Dardzinski, Bernard J; Hangartner, Thomas N; Duong, Le T

    2013-10-01

    Odanacatib (ODN) is a selective and reversible Cathepsin K (CatK) inhibitor currently being developed as a once weekly treatment for osteoporosis. Here, effects of ODN compared to alendronate (ALN) on bone turnover, DXA-based areal bone mineral density (aBMD), QCT-based volumetric BMD (vBMD) and geometric parameters were studied in ovariectomized (OVX) rhesus monkeys. Treatment was initiated 10 days after ovariectomy and continued for 20 months. The study consisted of four groups: L-ODN (2 mg/kg, daily p.o.), H-ODN (8/4 mg/kg daily p.o.), ALN (15 μg/kg, twice weekly, s.c.), and VEH (vehicle, daily, p.o.). L-ODN and ALN doses were selected to approximate the clinical exposures of the ODN 50-mg and ALN 70-mg once-weekly, respectively. L-ODN and ALN effectively reduced bone resorption markers uNTx and sCTx compared to VEH. There was no additional efficacy with these markers achieved with H-ODN. Conversely, ODN displayed inversely dose-dependent reduction of bone formation markers, sP1NP and sBSAP, and L-ODN reduced formation to a lesser degree than ALN. At month 18 post-OVX, L-ODN showed robust increases in lumbar spine aBMD (11.4%, p<0.001), spine trabecular vBMD (13.7%, p<0.001), femoral neck (FN) integral (int) vBMD (9.0%, p<0.001) and sub-trochanteric proximal femur (SubTrPF) int vBMD, (6.4%, p<0.001) compared to baseline. L-ODN significantly increased FN cortical thickness (Ct.Th) and cortical bone mineral content (Ct.BMC) by 22.5% (p<0.001) and 21.8% (p<0.001), respectively, and SubTrPF Ct.Th and Ct.BMC by 10.9% (p<0.001) and 11.3% (p<0.001) respectively. Compared to ALN, L-ODN significantly increased FN Ct. BMC by 8.7% (p<0.05), and SubTrPF Ct.Th by 7.6% (p<0.05) and Ct.BMC by 6.2% (p<0.05). H-ODN showed no additional efficacy compared to L-ODN in OVX-monkeys in prevention mode. Taken together, the results from this study have demonstrated that administration of ODN at levels which approximate clinical exposure in OVX-monkeys had comparable efficacy to ALN in

  2. Ação local do alendronato sódico na reparação óssea de ratos espontaneamente hipertensos (SHR Local action of sodium alendronate in bone repair of spontaneously hypertensive rat (SHR

    Directory of Open Access Journals (Sweden)

    Mônica Dal Pian Nobre

    2008-04-01

    Full Text Available FUNDAMENTO: A hipertensão arterial é uma desordem caracterizada por alterações relevantes no tecido ósseo. O alendronato sódico tem indicação no tratamento de doenças ósseas, por causa de sua afinidade pela hidroxiapatita, inibindo as reabsorções ósseas. OBJETIVO: Analisar a ação local do alendronato sódico na reparação óssea de ratos espontaneamente hipertensos (SHR. MÉTODOS: Um defeito ósseo foi criado no fêmur esquerdo de 80 ratos. De acordo com o material utilizado no local, criaram-se quatro grupos: controle (C, amido (Am, alendronato 1 mol (A1 e alendronato 2 mol (A2. Após 7 e 21 dias, os animais foram sacrificados. Foram realizadas análises histológicas e histomorfométricas e os dados foram submetidos a análise de variância (ANOVA e teste de Tukey (5%. RESULTADOS: Aos 7 dias, observou-se, na área do defeito, tecido conjuntivo com hemorragia e inflamação em todos os grupos. Alguns apresentavam matriz osteóide. Os grupos A1 e A2 apresentaram, ainda, uma rede de fibrina. Aos 21 dias, as trabéculas ósseas fechavam praticamente a extensão do defeito nos grupos C e Am. No grupo A1 de animais machos, observaram-se trabéculas que se irradiavam do canal medular até a área do defeito. Nos grupos A1 e A2, constatou-se apenas a presença de tecido conjuntivo com mínima deposição de osteóide. Um achado histológico marcante foi a formação de tecido ósseo extracortical subperiosteal nos animais dos grupos A1 e A2. CONCLUSÃO: Concluiu-se que a administração do alendronato sódico não contribuiu para o reparo ósseo nos ratos SHR, mas possivelmente tenha sido responsável pelas formações ósseas extracorticais observadas.BACKGROUND: The arterial hypertension is a disorder characterized by relevant alterations in the bone tissue. The sodium alendronate is indicated in the treatment of bone diseases, because of its affinity with the hydroxyapatite, inhibiting the bone reabsorptions. OBJECTIVE: To analyze

  3. 马克思对现代性形而上学基础的批判及其哲学革命%The Basis of Marx's Critique and the Philosophy of Modern Metaphysics of Revolution

    Institute of Scientific and Technical Information of China (English)

    黄明娣

    2012-01-01

    Various contradictions of modernity behind its profound metaphysical foundation are the philosophy of modem rational- ism, in other words, modem philosophy, hut modem rationalism of the "root. " Radical critique of modernity led Marx to the modem requirements of the metaphysical basis of modern rational philosophy of the two foundations the abstract and the abstract body to criticism, to overcome the metaphysical way of thinking, then move toward philosophical revolution, the final creation of the practice as the fundamental point of view of its philosophy of "new materialism. " Therefore, the basis of Marx's metaphysics of the modem philos- ophy of criticism of modem rationalism is the philosophy of the revolutionary path appearance of reality, and its philosophy of revolution is its radical critique of modern philosophy conclusions. In other words, the modern basis of modem rationalism and its metaphysical philosophy and Marx's philosophical revolution is not by chance among the external implications, but integral to inter-related with.%现代性诸矛盾现象背后有其深刻的形而上学基础,这就是近代理性主义哲学。对现代性批判的彻底性要求导致马克思对现代性的形而上学基础近代理性主义哲学的两大根基——抽象本体和抽象的人进行批判,颠覆其形而上学的思维方式,进而走向哲学革命,最终创立以实践作为其哲学根本观点的"新唯物主义"。因此,马克思对近代理性主义哲学的批判是其哲学革命出场的现实路径,而其哲学革命则是其现代性批判彻底化的哲学结论。

  4. The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats Influência da ovariectomia, da sinvastatina e do alendronato sódico no osso alveolar em ratas

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    Ana Lia Anbinder

    2007-09-01

    Full Text Available Bisphosphonates are currently used in the treatment of many diseases involving increased bone resorption such as osteoporosis. Statins have been widely used for the treatment of hypercholesterolemia and recent studies have shown that these drugs are also capable of stimulating bone formation. The purpose of this study was to evaluate the influence of an estrogen deficient state and the effects of simvastatin and sodium alendronate therapies on alveolar bone in female rats. Fifty-four rats were either ovariectomized (OVX or sham operated. A month later, the animals began to receive a daily dose of simvastatin (SIN - 25 mg/kg, sodium alendronate (ALN - 2 mg/kg or water (control orally. Thirty-five days after the beginning of the treatment, the rats were sacrificed and their left hemimandibles were removed and radiographed using digital X-ray equipment. The alveolar radiographic density under the first molar was determined with gray-level scaling and the values were submitted to analysis of variance (a = 5%. Ovariectomized rats gained more weight (mean ± standard deviation: 20.06 ± 6.68% than did the sham operated animals (12.13 ± 5.63%. Alveolar radiographic density values, expressed as gray levels, were lowest in the OVX-water group (183.49 ± 6.47, and differed significantly from those observed for the groups receiving alendronate (sham-ALN: 193.85 ± 3.81; OVX-ALN: 196.06 ± 5.11 and from those of the sham-water group (193.66 ± 4.36. Other comparisons between groups did not show significant differences. It was concluded that the ovariectomy reduced alveolar bone density and that alendronate was efficient for the treatment of this condition.Os bisfosfonatos são empregados atualmente para o tratamento de várias doenças caracterizadas pelo aumento da reabsorção óssea, como a osteoporose. As estatinas são amplamente utilizadas para redução de níveis elevados de colesterol e estudos recentes têm revelado sua ação anabólica no osso

  5. LAS CRÍTICAS DE ARISTÓTELES A PLATÓN EN METAFÍSICA I, 9 ARISTOTLE’S CRITICISMS OF PLATO IN METAPHYSICS I, 9

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    Silvana Gabriela Di Camillo

    2011-03-01

    Full Text Available

    O recurso à exposição crítica das doutrinas anteriores é um procedimento metodológico usual em Aristóteles. Mas a característica distintiva do Livro I da Metafísica é que, ao invés de estabelecer uma nova doutrina, o exame dos predecessores serve para confirmar os próprios conceitos aristotélicos, os quais ele usa para avaliar os êxitos e os erros das doutrinas analisadas. Essa imposição de conceitos próprios lhe valeu a acusação de ter uma compreensão histórica distorcida. Com a análise detalhada das críticas da teoria platônica das Idéias na Metafísica I, 9, pretendemos mostrar: a que as críticas de manipulação e distorção das opiniões dos seus antecessores ofuscam o grau em que as suas próprias posições emergem de uma análise crítica do pensamento anterior; e b que a imposição de conceitos próprios não é uma distorção, mas uma proposta de solução para os problemas que as teorias anteriores deixaram sem solução.

    The use of critical exposition of previous doctrines is a methodological procedure usual in Aristotle. But the distinctive characteristic of Book I of the Metaphysics is that, rather than to establish a new doctrine, a review of  predecessors serves to confirm the own concepts to be used in the evaluation of the doctrines examined. This imposition of own terms has cost him the charge of distorting historical understanding. With the detailed analysis of the criticisms of Plato's theory of Ideas in Metaphysics I, 9, we intend to show a that the criticism of manipulation and distortion of his predecessors' views overshadow the degree to which Aristotle's own positions emerge from a critical review of previous thought and b that the

  6. The fate of the hip in spondylo-epi-metaphyseal dysplasia: clinical and radiological evaluation of adults with SEMD Handigodu type

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    Siddesh, N.D.; Shah, Hitesh; Joseph, Benjamin [Kasturba Medical College, Paediatric Orthopaedic Service, Manipal, Karnataka State (India)

    2012-08-15

    This study was undertaken to document the fate of the hip with reference to its structure and function in patients with spondylo-epi-metaphyseal dysplasia tarda Handigodu type (SEMD{sub HG}). Radiographs of 271 adult patients with SEMD{sub HG} were studied to identify the pattern of long-term sequelae in the hips. Several measurements of the proximal femur and acetabulum were made to quantify morphological alterations in the hip. Fifty-four adult patients were examined and administered a questionnaire to evaluate the extent of disability attributable to the hips. Three patterns of changes in the hips were noted: 35% had acetabular protrusio, 33% had subluxation of the hip, and 32% had no protrusio or subluxation. Distinctly different anthropometric measurements and dimensional alterations around the hip were noted in these three patterns. Patients with protrusio were relatively tall while those with subluxation were the shortest. All the patients had developed degenerative arthritis of the hips by the fourth decade of life irrespective of the pattern of hip involvement. The reduction in the range of hip motion and fixed deformities were most severe in patients with protrusio. All the patients had significant disability and very low functional hip scores. Degenerative arthritis of the hip develops in the majority of patients with SEMD{sub HG}; the symptoms are severe enough to warrant reconstructive surgery by the fourth decade of life. Protrusio or subluxation develops in a third of the patients each; both these complications will influence the surgical approach if total hip arthroplasty is planned. (orig.)

  7. Adorno’s criticism of Metaphysics in the Negative Dialectics%浅析阿多诺《否定的辩证法》中的形而上学批判

    Institute of Scientific and Technical Information of China (English)

    邵晓丹

    2014-01-01

    Adorno criticized metaphysics in his book, Negative Dialectics.The main target are the identity, concept imperialism and system which among the traditional metaphysics. He think the identity thought need to be criticized because it destroy the variety and peculiar in the phenomenon world and want to dispel every contradiction. Meantime, Adorno also repudiate Heidegger' view of metaphysics ,especially the his concept of Being and Existential ontology. In the end , Adorno bring forward his negative dialectics and constellation concept where the negative dialectics lives in.%阿多诺在《否定的辩证法》一书中对形而上学进行了批判,主要批判了形而上学传统中的同一性思维、概念帝国主义以及体系性。阿多诺认为同一性思想破坏了现象界的多样性和特殊性,妄图消解一切矛盾是需要批判的。同时,阿多诺也批判了海德格尔的形而上学观,特别是海德格尔的存在概念和基础本体论。最后,阿多诺提出了自己的否定的辩证法并且建构了这一理论存在的空间-星丛。否定的辩证法强调非同一性和彻底的否定性,注重特殊性和个别性。

  8. 复杂性理论的形而上学问题与建构策略研究%A Study on the Metaphysical Problems and Construction Tactics of the Theories of Complexity

    Institute of Scientific and Technical Information of China (English)

    赵伟

    2011-01-01

    当今时代,各种复杂性理论变体对于经典形而上学思维带来了挑战,并引起了人们对于复杂性理论是否是科学的怀疑。为了理解什么是复杂性以及怎么应对它所带来的形而上学新问题。首先,给出一个关于复杂性的相对定义,并介绍"复杂性"理论的三个发展阶段成果;其次,比较研究经典思维和复杂性思维的形而上学预设的冲突;最后,建构适应于复杂性理论的形而上学的构成承诺和构成原则。%Nowadays,all kinds of theories of complexity have brourht about challenges to the classical metaphysical thinking,and cause people to be doubtful whether the theories of complexity are scientific.In order to understand what is complexity and how to cope with the new metaphysical problems it produced.Firstly,give a relevant notion about complexity,and offers a chronological presentation of three generations of theories that have shaped its uses;secondly,compare and study the comflicts of metaphysical preferences between the classical thinking and the complexity thinking;in the end,construct the constitutive commitments and the constitutive principles which are adapted to complexity theories.

  9. Influence of treatment with alendronate on the speed of sound, an ultrasound parameter, of the calcaneus in postmenopausal Japanese women with osteoporosis: a clinical practice-based observational study

    Directory of Open Access Journals (Sweden)

    Iwamoto J

    2012-06-01

    Full Text Available Jun Iwamoto,1 Tetsuya Takada,2 Yoshihiro Sato,3 Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, 2Department of Internal Medicine, Hiyoshi Medical Clinic, Kanagawa, 3Department of Neurology, Mitate Hospital, Fukuoka, JapanPurpose: The influence of alendronate (ALN treatment on the quantitative ultrasound parameters of the calcaneus remains to be established in Japanese patients. The aim of the present clinical practice-based observational study was to examine the influence of ALN treatment for 1 year on the speed of sound (SOS of the calcaneus and bone turnover markers in postmenopausal Japanese women with osteoporosis.Patients and methods: Forty-five postmenopausal Japanese women with osteoporosis who had received treatment with ALN for more than 1 year were enrolled in the study. The SOS and bone turnover markers were monitored over 1 year of ALN treatment.Results: The urinary levels of cross-linked N-terminal telopeptides of type I collagen and serum levels of alkaline phosphatase decreased significantly from the baseline values (–44.9% at 3 months and –22.2% at 12 months, respectively. The SOS increased modestly, but significantly, from the baseline value (0.6% at both 6 and 12 months. The percentage decrease in the urinary levels of cross-linked N-terminal telopeptides of type I collagen at 3 months was significantly correlated with the percentage increase in the SOS only at 6 months (correlation coefficient, 0.299.Conclusion: The present study confirmed that ALN treatment suppressed bone turnover, producing a clinically significant increase in the SOS of the calcaneus in postmenopausal Japanese women with osteoporosis.Keywords: postmenopausal osteoporosis, quantitative ultrasound (QUS, SOS, bone turnover, biochemical markers

  10. Open, Prospective, Multi-Center, Two-Part Study of Patient Preference with Monthly Ibandronate Therapy in Women with Postmenopausal Osteoporosis Switched From Daily or Weekly Alendronate or Risendronate-BONCURE: Results of Turkish Sub-Study

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    Nurten Eskiyurt

    2012-04-01

    Full Text Available Aim: BONCURE (Bonviva for Current Bisphosphonate Users Regional European Trial, aimed to evaluate patient preference with monthly ibandronate in women with postmenopausal osteoporosis who previously received daily or weekly alendronate or risendronate. Materials and Methods: This prospective, open-label study consisted of two sequential stages, Part A (screening and Part B (treatment. Patients enrolled into Part A completed the Candidate Identification Questionnaire (CIQ. In Part B, after completing the Osteoporosis Patient Satisfaction Questionnaire (OPSATQ, patients received monthly oral ibandronate 150 mg for 6 months. Following treatment, patients completed the OPSAT-Q and Preference Questionnaire. Results: A total of 223 patients (mean age, 63.7±9.51 years were enrolled in Part A from Turkey. Among them, 103 (46.2% answered “YES” to at least one CIQ question. The mean composite OPSAT-Q domain scores increased for convenience (mean change, 15.3±17.7 points, quality of life (10.4±20.4 points, overall satisfaction (11.9±22.7 points, and side effects (3.3±18.8 points. At month 6, 177 subjects (92.7% preferred once-monthly dosing schedule and 99.0% were compliant (≥80% with study treatment. Thirty (15.6% subjects experienced mild to moderate adverse events, mostly gastrointestinal. Conclusion: Postmenopausal women with osteoporosis prefer and are more satisfied and compliant with monthly dosing of ibandronate than daily or weekly bisphosphonate treatment. (Turkish Journal of Osteoporosis 2012;18:1-7

  11. High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate.

    Science.gov (United States)

    Cabal, Antonio; Jayakar, Richa Y; Sardesai, Swanand; Phillips, Eual A; Szumiloski, John; Posavec, Diane J; Mathers, Parker D; Savitz, Alan T; Scott, Boyd B; Winkelmann, Christopher T; Motzel, Sherri; Cook, Lynn; Hargreaves, Richard; Evelhoch, Jeffrey L; Dardzinski, Bernard J; Hangartner, Thomas N; McCracken, Paul J; Duong, Le T; Williams, Donald S

    2013-10-01

    Translational evaluation of disease progression and treatment response is critical to the development of therapies for osteoporosis. In this study, longitudinal in-vivo monitoring of odanacatib (ODN) treatment efficacy was compared to alendronate (ALN) in ovariectomized (OVX) non-human primates (NHPs) using high-resolution peripheral computed tomography (HR-pQCT). Treatment effects were evaluated using several determinants of bone strength, density and quality, including volumetric bone mineral density (vBMD), three-dimensional structure, finite element analysis (FEA) estimated peak force and biomechanical properties at the ultradistal (UD) radius at baseline, 3, 6, 9, 12, and 18 months of dosing in three treatment groups: vehicle (VEH), low ODN (2 mg/kg/day, L-ODN), and ALN (30 μg/kg/week). Biomechanical axial compression tests were performed at the end of the study. Bone strength estimates using FEA were validated by ex-vivo mechanical compression testing experiments. After 18months of dosing, L-ODN demonstrated significant increases from baseline in integral vBMD (13.5%), cortical thickness (24.4%), total bone volume fraction BV/TV (13.5%), FEA-estimated peak force (26.6%) and peak stress (17.1%), respectively. Increases from baseline for L-ODN at 18 months were significantly higher than that for ALN in DXA-based aBMD (7.6%), cortical thickness (22.9%), integral vBMD (12.2%), total BV/TV (10.1%), FEA peak force (17.7%) and FEA peak stress (11.5%), respectively. These results demonstrate a superior efficacy of ODN treatment compared to ALN at the UD radii in ovariectomized NHPs. PMID:23791777

  12. Efectos de los productos de glicación avanzada (AGEs y alendronato sobre el desarrollo osteoclástico: posibles mecanismos de acción Effect of Advanced Glycation Endproducts and Alendronate on osteoclastic development: possible mechanisms of action

    Directory of Open Access Journals (Sweden)

    María Virginia Gangoiti

    2012-03-01

    effect of AGEs and Alendronate (an N-containing BP on the development of Oc in culture, as well as possible mechanisms of action involved in these effects. Materials and Methods: RAW264.7 macrophages and UMR106 osteoblasts were co-cultured for 8 days, with BSA or AGEs (50-200 µg/ml, with or without Alendronate (10-8-10-4M. The effect of these culture conditions on Oc formation was evaluated (number of Oc, cell-associated tartrate-resistant acid phosphatase [TRAP] activity, as well as Oc expression of RAGE (receptor for AGEs, and osteoblastic expression of RANK ligand (RANKL. These last two parameters were evaluated by indirect immunofluorescence, in order to estimate the expression and sub-cellular distribution of both membrane-associated proteins. Results: AGEs (50-200 µg/ml dose-dependently inhibited TRAP activity (10-30 % and the number of multinucleated Oc (55 %. Similar results were observed for low doses of Alendronate (10-8M-10-6M. The co-incubation of low doses of Alendronate with 100 mg/ml of AGEs, did not induce an additional inhibition of TRAP activity or Oc number, to that observed for AGEs alone. High levels of Alendronate (10-5M-10-4M inhibited Oc TRAP activity (20-25 % inhibition versus BSA, and 17 % versus AGEs, and also decreased the number of Oc formed in the presence of AGEs (16 % inhibition versus AGEs. Oc incubated in the presence of 100 µg/ml AGEs, showed a significant increase in the expression of RAGE (152 % versus BSA. Similar results were found after incubating with 10-8M Alendronate (130 % versus BSA. On the contrary, high doses of Alendronate (10-5M did not affect the expression of RAGE in co-cultures incubated with BSA (95 % versus BSA. On the other hand, low doses of Alendronate in the presence of AGEs, did not affect the up-regulation of RAGE induced by AGEs (145 % versus BSA. However, when the Oc were co-incubated with AGEs and 10-5M Alendronate, this dose of BP was able to block the stimulation of RAGE expression induced by AGEs (105

  13. Metaphysical Presuppositions of Modern Science

    Directory of Open Access Journals (Sweden)

    Ernest Wolf-Gazo

    2011-12-01

    Full Text Available This essay intends to show that science, especially the natural sciences, operate on presuppositions. In a nutshell view of aspects of the history of science the presuppositions, as part of the relevant historical context, operate within the scientific enterprise. Science used to be views as positivist and final; yet, the logic of methodology, from E.A. Burtt to T.S. Kuhn and Karl Popper show that presuppositions are part of the scientific research. Particularly the pioneering work of the archeologist and philosopher R.G. Collingwood and the seminal thinker S.N. Nasr, who opened the doors for the inquiry of the role of science within Islamic Civilization, are highlighted. We show that the tension between the humanities (human sciences and the natural sciences still exist and need to be explored on a global level, especially as to their cultural presuppositions involved.

  14. On the Metaphysics of the Buddhist Images in Wei,Jin and Southern and Northern Dynasties%浅谈魏晋南北朝佛教造像中的玄学之风

    Institute of Scientific and Technical Information of China (English)

    李沫; 李妍

    2011-01-01

    魏晋南北朝时期,尤其是北魏中期的佛教造像中流行一种"秀骨清象"的造像艺术风格。它表现的是当时玄学清谈家所崇尚的道骨风韵,这个时期正是南北朝佛教与玄学融合交流的重要的时期,而佛教造像玄学化的重要标志即佛教造像的"秀骨清象。"%In the period of Jin and Southern and Northern Dynasties,especially in the middle of Northern Wei dynasty,the image art style " Clear Appearance by Drawing" is popular in Buddhist images.It shows the religion charm that metaphysics talker admires,and simultaneously,this period is an important period combining Buddhism in Southern and Northern Dynasties with metaphysics,in which " Clear Appearance by Drawing" is regarded as the important sign of Buddhist images.

  15. 从形而上学到现象学:哲学为科学奠基%From Metaphysics to Phenomenology:the Philosophy Laying a Foundation for Science

    Institute of Scientific and Technical Information of China (English)

    朱光亚

    2013-01-01

    哲学为科学奠基是西方哲学的一个传统。自古希腊哲学以来,传统意义上的形而上学一直起着为科学奠基的作用。但是,随着本体论向认识论的转向,各门具体科学从形而上学的母体中脱离出来而导致哲学虚无化,心理主义逐渐成为各门具体科学的基础。反心理主义和心理主义的斗争在认识论领域内几乎始终相伴而行,康德就站在反心理主义的立场,试图重建形而上学。但是康德对心理主义的批判是不彻底的,心理主义发展的势头非但没有减弱,反而在近代达到了空前的繁荣。对心理主义批判的工作由胡塞尔完成,他论证逻辑学的基础不是心理主义,致力于构建一门纯粹逻辑学,重构了哲学对科学的奠基作用。%The philosophy laying a foundation for scientific is a tradition in western philosophy. From the ancient Greek philosophy, traditional metaphysics always plays the role of foundation for science. However, with the transform from ontology to epistemology, each specific discipline was separated form the matrix of metaphysics, which resulted in nihilization of philosophy, then psychologism gradually became the basis of specific scientific. The struggle of anti-psychologism and psychologism almost always go together in the field of epistemology. Kant stood on the position of anti-psychologism, trying to rebuild metaphysics. But Kant’s critique is incomplete. Psychologism’s development momentum was not weakened, inversely it got an unprecedented prosperity in modern times. Husserl performed the work of critique psychologism, in which he argument that the basis of logic is not psychologism, and committed to build a pure logic, which rebuilt the role of foundation philosophy to science.

  16. 形而上学的“围城”——答谢崛博士%A Besieged City of Metaphysics —— An answer with Doctor Xie Jue

    Institute of Scientific and Technical Information of China (English)

    邓晓芒

    2011-01-01

    Xie Jue's article contains a series of fallacies. The first of which is a misunderstanding of the construction of Chinese and Western metaphysics itself, because the Chinese traditional metaphysics is not simply based on practise and the Western metaphysics is not simply about epistemology. The comparison between them should be built on the specific structure of these two elements, but not on the presence of them. Otherwise, one is oversimplifying the issue. The second fallacy is that he made several wrong descriptions about the history of Philosophy. For example, he misunderstands Aristotle's ontology, and asserts that no one before Kant linked metaphysics to people's practice, as well as a superficial view of the Western hypocrisy, his misreading of Kant's concept of freedom and Hegel's "reality is reasonable" propositions, etc. The above mentioned evidences have shown that he was not familiar with the history of Western philosophy. The third is that his evaluation of these facts is with a kind of bias prejudice, which may be reasonable in the perspective of Western society, but in the context of Chinese society, it revealed a "Fortress Besieged" phenomenon. The fourth is that from his sense of good and evil, of freedom, of reflection and of faith, etc. , it reflects a tendency of being strongly racist, which is not conducive to the clarification of theoretical issues.%谢崛的文章包含一系列谬误,一是对中西形而上学本身的构成方式有误解,因为中国传统形而上学不仅仅是实践论的,而西方形而上学也不仅仅是认识论的,双方的比较应该建立在这些要素的结构模式上,而不是有无某种要素上,否则是失之简单化的;二是对哲学史的诸多事实作了错误的描述,如对亚里士多德存在论的误解和断言康德以前没有人把形而上学与实践的人相联系,以及对西方伪善观的肤浅化,对康德自由观、黑格尔“现实的就

  17. Histomorphometric Assessment of Cancellous and Cortical Bone Material Distribution in the Proximal Humerus of Normal and Osteoporotic Individuals: Significantly Reduced Bone Stock in the Metaphyseal and Subcapital Regions of Osteoporotic Individuals.

    Science.gov (United States)

    Sprecher, Christoph M; Schmidutz, Florian; Helfen, Tobias; Richards, R Geoff; Blauth, Michael; Milz, Stefan

    2015-12-01

    Osteoporosis is a systemic disorder predominantly affecting postmenopausal women but also men at an advanced age. Both genders may suffer from low-energy fractures of, for example, the proximal humerus when reduction of the bone stock or/and quality has occurred.The aim of the current study was to compare the amount of bone in typical fracture zones of the proximal humerus in osteoporotic and non-osteoporotic individuals.The amount of bone in the proximal humerus was determined histomorphometrically in frontal plane sections. The donor bones were allocated to normal and osteoporotic groups using the T-score from distal radius DXA measurements of the same extremities. The T-score evaluation was done according to WHO criteria. Regional thickness of the subchondral plate and the metaphyseal cortical bone were measured using interactive image analysis.At all measured locations the amount of cancellous bone was significantly lower in individuals from the osteoporotic group compared to the non-osteoporotic one. The osteoporotic group showed more significant differences between regions of the same bone than the non-osteoporotic group. In both groups the subchondral cancellous bone and the subchondral plate were least affected by bone loss. In contrast, the medial metaphyseal region in the osteoporotic group exhibited higher bone loss in comparison to the lateral side.This observation may explain prevailing fracture patterns, which frequently involve compression fractures and certainly has an influence on the stability of implants placed in this medial region. It should be considered when planning the anchoring of osteosynthesis materials in osteoporotic patients with fractures of the proximal humerus.

  18. How is Non-metaphysical Ethics Possible---On the Methodology of Hume′s Ethics%非形而上学的伦理学如何可能--休谟伦理学方法论探析

    Institute of Scientific and Technical Information of China (English)

    黄济鳌

    2014-01-01

    传统理性主义伦理学认为,道德是理性认识永恒的是非标准并通过自由意志指导行为的结果。休谟将经验主义贯彻到底,导致了伦理学方法论上的非形而上学转向,认为理性不能认识超经验的是非标准,因而自由意志和理性的能动作用就失去了依据,他进而提出情感才是道德区别的标准和伦理学研究的主要对象。休谟据此建立的以情感进步观为基本特征的德性伦理学对西方现代伦理学的发展产生了深远影响。%According to traditional rationalism ethics, a behavior is virtuous because it is guided by free will subject to reason that can find eternal standard about right and wrong. Hume carries through empiricism and leads to the turn of ethical methodology from metaphysics to non-metaphysics, and thinks reason can not obtain the metempirical standard about right and wrong, so there is no basis for the initiative of reason and free will. Furthermore Hume puts forward that moral sentiments are the main research objects of ethics, and are the standards which distinguish between virtues and vices. Hume has further established virtue ethics of sentimentalism, which is characterized by the view of the progress of sentiments, and which has a far-reaching impact on the development of modern western ethics.

  19. Eldecalcitol improves muscle strength and dynamic balance in postmenopausal women with osteoporosis: an open-label randomized controlled study.

    Science.gov (United States)

    Saito, Kimio; Miyakoshi, Naohisa; Matsunaga, Toshiki; Hongo, Michio; Kasukawa, Yuji; Shimada, Yoichi

    2016-09-01

    The antifracture efficacy of vitamin D in osteoporosis is due to its direct action on bones and indirect extraskeletal effects to prevent falls. Eldecalcitol is an analog of active vitamin D3 that improves bone mineral density and reduces the risk of osteoporotic fractures. However, the effects of eldecalcitol on muscle strength and static and dynamic postural balance are unclear. In this open-label randomized controlled study, we assessed the effects of eldecalcitol on muscle strength and static and dynamic postural balance in 50 postmenopausal women (mean age 74 years) with osteoporosis treated with bisphosphonate. Participants were randomly divided into a bisphosphonate group (alendronate at 35 mg/week; n = 25) or an eldecalcitol group (eldecalcitol at 0.75 μg/day and alendronate at 35 mg/week; n = 25) and were followed up for 6 months. Trunk muscle strength, including back extensor strength and iliopsoas muscle strength, was measured. Static standing balance was evaluated and the one leg standing test was performed to assess static postural balance. Dynamic sitting balance was evaluated and the 10-m walk test, functional reach test, and timed up and go test were performed to assess dynamic postural balance. At 6 months, there were no significant changes in any measure of muscle strength or balance in the bisphosphonate group, whereas eldecalcitol significantly increased back extensor strength (p = 0.012) and iliopsoas muscle strength (p = 0.035). Eldecalcitol also significantly improved findings on the timed up and go test (p = 0.001) and dynamic sitting balance (p = 0.015) at 6 months. These results with eldecalcitol may have an impact on prevention of falls.

  20. Osteoporosis grave con aplastamientos vertebrales en dermatomiositis juvenil: Efecto del tratamiento con alendronato oral Severe osteoporosis with vertebral crushes in juvenile dermatomyositis: Effect of oral alendronate therapy

    Directory of Open Access Journals (Sweden)

    Cristina Tau

    2007-02-01

    Full Text Available Los glucocorticoides son usados comúnmente para el tratamiento de enfermedades inflamatorias, autoinmunes, enfermedades malignas, y en la prevención de rechazo de órganos trasplantados. Un efecto secundario frecuente del tratamiento prolongado es la pérdida de masa ósea que se produce por varios mecanismos y es causa de osteoporosis y fracturas vertebrales. El tratamiento con disfosfonatos ha sido propuesto para esta situación. Presentamos un caso clínico de osteoporosis grave en una niña con dermatomiositis juvenil, que respondió favorablemente al tratamiento con disfosfonatos orales.Glucocorticoids are used for the treatment of inflammatory and autoimmune diseases, cancer, and in prevention of organ rejects. A frequent secondary effect of longterm treatment with corticoids is the loss of bone mass, caused by several mechanisms: decrease in the intestinal calcium absorption, increase of the renal calcium excretion at the distal renal tubule, suppressive effect on the osteoblast and also in apoptosis of osteoclasts, inhibition in local production of IGF I (Insulin-like growth factor and IGFBPs (binding IGF I proteins necessary for bone metabolism, and decrease on osteocalcin production. Longterm treatment with corticoids is associated with osteoporosis and vertebral fractures. To improve this condition, treatment with bisphosphonates has been proposed. We present here a clinical case of a girl with dermatomyositis and severe osteoporosis with vertebral crushes, who responded well to oral bisphophonate treatment.

  1. Efeitos do treinamento resistido sobre variáveis relacionadas com a baixa densidade óssea de mulheres menopausadas tratadas com alendronato Effects of resistance training on low bone density-related variables in menopausal women taking alendronate

    Directory of Open Access Journals (Sweden)

    Cláudio Joaquim Borba-Pinheiro

    2010-04-01

    Full Text Available A osteoporose é uma doença crônica que atinge o esqueleto humano. OBJETIVO: Verificar os efeitos do treinamento resistido sobre a densidade mineral óssea (DMO, força muscular, equilíbrio e qualidade de vida em mulheres menopausadas em tratamento com alendronato. MÉTODOS: Participaram do estudo 16 voluntárias. Elas foram separadas em dois grupos: que praticaram o treino resistido (n = 9, 49,7 ± 4,2 idade e que constituíram o grupo controle (n = 7, 53,8 ± 4,4 idade. Os instrumentos de avaliação seguintes foram usados: a absorciometria de dupla energia por raios X -DXA (que mediu a coluna lombar L2-L4, colo do fêmur, triângulo de Wards e trocanter maior, o Osteoporosis Assessment Questionnaire (OPAQ e um teste de equilíbrio. O treinamento foi periodizado em 12 meses, divididos em seis ciclos com intensidade de 70-90% da carga máxima (10RM. Testes paramétricos (t ou Wilcoxon, para análise intragrupo e (Anova para intergrupos, foram usados. RESULTADOS: Foram encontradas diferenças significativas favoráveis ao grupo que treinou nos sítios da lombar L2-L4 (6,8%, p = 0,001, colo do fêmur (4,8%, p = 0,005 e trocanter (0,76%, p = 0,005. Além de diferenças significativas também para o equilíbrio corporal (21,4%, p = 0,001, qualidade de vida (9,1%, p = 0,001 e todas as medidas de força como na pressão de pernas 45° (49,3%, p Osteoporosis is a chronic disease of the human skeleton. OBJECTIVE: To verify the effects of resistance training on bone mineral density (BMD, muscular strength, balance and quality of life in menopausal women taking Alendronate. MATERIALS AND METHODS: Sixteen female volunteers participated in the study. The volunteers were separated into two groups: resistance training participants (n=9; 49.7±4.2 years and control group (n=7; 53.8±4.4 years. The following evaluation instruments were used: absorptiometry-DXA (which measured the lumbar spine L2-L4, neck femur, Wards triangle and major trochanter, the

  2. Radiographic and histological evaluation of bisphosphonate alendronate and metotrexate effects on rat mandibles inoculated with Walker 256 carcinosarcoma Avaliação radiográfica e histológica do efeito do bisfosfonato alendronato e do metotrexato na mandíbula de ratos inoculados com carcinossarcoma 256 de Walker

    Directory of Open Access Journals (Sweden)

    Ana Paula Negreiros Nunes Alves

    2007-12-01

    Full Text Available PURPOSE: To investigate the effects of bisphosphosnate alendronate (ALD and metotrexate (MTX on an experimental model of Walker 256 carcinosarcoma developed in the oral cavity of rats. METHODS Walker 256 carcinosarcoma cell suspension (0,1 mL containing 10(6 cell/mL was implanted in the alveoli of the first and second molars. The animals were divided and treated with saline, MTX, ALD, and MTX plus ALD. Later, the animals were sacrificed, the tumors were measured and the mandibles were removed for radiographic and histological analysis. RESULTS: In the control group, the radiographic images demonstrated radioluscency with poorly defined borders, and the microscopic examination revealed tumor infiltration into the peripheral and central regions of the bone. Areas of necrosis were commonly seen. In the treated groups with ALD, associated or not with MTX, the radiographic analysis revealed circumscribed tumor-induced osteolysis and various degrees of radiotransparence; while, histologically, preserved bone trabeculae with osteoid formation was observed among malignant cells. CONCLUSION: The bisphosphonate alendronate exherted an osteoprotective effect and induced bone neoformation on the Walker 256 carcinosarcoma inoculated in rat mandibles. The combination of metotrexate with bisphosphonate alendronate is more successful than treatment with the agents alone in controlling the growth of neoplastic cells and in stimulating reactive new bone. Therefore, this may be an alternative treatment to malignant lesions of maxillaries with osteolysis.OBJETIVO: Avaliar o efeito do bisfosfonato alendronato (ALD e do metotrexato (MTX em modelo do carcinossarcoma 256 de Walker na mandíbula de ratos. MÉTODOS: Uma suspensão de células tumorais do carcinossarcoma 256 de Walker (0,1mL, na concentração de 10(6 células/mL, foi implantada nos alvéolos de ratos previamente abertos por exodontia. Os animais foram divididos em grupos e tratados com salina, MTX, ALD e

  3. The comparison between alendronate and active vitamin D3 in controlling glucocorticoid induced osteoporosis in premenopausal patients with systemic lupus erythematosus%阿伦膦酸钠与活性维生素D3对比防治绝经期前SLE患者GIOP

    Institute of Scientific and Technical Information of China (English)

    刘颖; 张晓; 崔阳; 雷云霞; 张光峰; 谢悦胜

    2012-01-01

    Objective To observe comparatively the efficacies between alendronate and active vitamin D3 in controlling glucocorticoid induced osteoporosis (GIOP) in premenopausal patients with systemic lupus erythematosus (SLE) and without a history of fragility fracture. Methods 91 premenopausal female SLE patients with low-dose glucocorticoids (GCs) therapy or high-dose GCs therapy were divided into 2 groups, including 47 patients who were collected from the outpatient department and received low-dose GCs and 44 patients who were collected from the inpatient department and received high-dose GCs. The patients with either therapy were randomly divided into 3 groups: the calcium group, calcium plus active vitamin D3 group and calcium plus alendronate group. Bone metabolism serological markers and bone mineral density (BMD) values were tested in the first 0, 3 and 6 months. The incidence of fractures and femoral head necrosis was recorded during the treatment process. Results (1) In all groups with low-dose GCs therapy, there was no significant difference in the serum levels of calcium (Ca), inorganic phosphate (PO4) and alkaline phosphatase (ALP) before and after treatment. The serum levels of N-MID osteocalcin (N-MID) and β collagen decomposition segment (β-CT) significantly decreased after the treatment in the calcium plus alendronate group (P0.05). In the calcium plus alendronate group, the BMD values significantly increased after the treatment (P0.05). (3) There was no fracture and femoral head necrosis in all groups with low-dose GCs therapy. In all groups with high-dose GCs therapy, femoral head necrosis occurred in the calcium group and calcium plus active vitamin D3 group, and meanwhile, there was no femoral head necrosis in the calcium plus alendronate group. Conclusions When premenopausal female SLE patients receive low-dose or high-dose GCs therapy respectively, alendronate can better decrease bone turnover, increase BMD and reduce the incidence of femoral head

  4. 个体与社会--论魏晋玄学“群己之辨”%The individual and society---analysis of “Argument of Group and Individual”about metaphysics of the Wei and Jin dynasties

    Institute of Scientific and Technical Information of China (English)

    徐磊

    2015-01-01

    魏晋玄学的三大理论主题即:有无之辨、情理之辨和群己之辨,三者具有紧密的联系。有无之辩落实到人生层面,就是关乎自然与名教的情理之辩,而自然和名教之辩背后所蕴含的即是人的主题。个体重自然,社会尚名教,从名教与自然之辨,必然引申到群己之辨。在三国两晋时期,由于动荡的社会环境,导致自然与名教发生严重的分离,同时,这种分离也明显地体现了理想与现实、自由与道德、个体与社会之间所存在的冲突。如何去调整或者把握自然与名教、个体与社会的关系以达到彼此的统一,成为玄学的重要理论课题。%The three argumentative topics in the metaphysics of Wei and Jin dynasties refers to existing and nothing;emotions and reasons;and group and individual,which has close relationship among each other.From the aspect of human being,the argument of existing and nothing is the very argument of emotions and reasons between the Confu-cian Ethical Code and nature.Meanwhile,the key subject implied in the argument of the Confucian Ethical Code and nature is just the human beings.Individual prizes nature;and society upholds the Confucian Ethical Code.Nec-essarily,the argument of the Confucian Ethical Code and nature can extend to the argument of group and individual. During the period of Three Kingdoms and Two Jins dynasties,and due to the turbulent social environment,nature and the Confucian Ethical Code had been separated seriously.Obviously at the same time,this separation also re-flects the conflict between ideal and reality,freedom and morality,individual and the society.It becomes an impor-tant theoretical issue in metaphysics that how to cognitive or adjust the relationship between the nature and the Con-fucian Ethical Code,and between individual and the society for the achievement of the unity of each other.

  5. 后形而上学视域中理查德·罗蒂的小说伦理%Richard Rorty’s Novel Ethics in the Post-Metaphysical Culture

    Institute of Scientific and Technical Information of China (English)

    殷振文

    2014-01-01

    “Ethics” has become one of the keywords for postmodern philosophy .Ethics’ literary turn , which makes contemporary philosophers rethink the relationship between ethics and literature , has brought about the ethical turn of literary criticism .The ironical philosopher Richard Rorty proclaims in his post-metaphysics thought that novel is a powerful weapon for criticizing metaphysical essentialism and foundationalism .In the public dimension ,as a typical genre of social democracy ,novel reveals the cruelty w hich is human’s first vice .Novel reading also plays a great role in offering new opportunities for people to know themselves and re-describe themselves ,renewing people’s imagination for the way of well-living . Novel reading might help people to get rid of egotism to realize the multiple modes of human livings and the contingency of human selfhood and language .In this sense ,Rorty advocates the novel ethics .He also emphasizes that for contemporary people novel reading might be the best way for virtue education and mind’s edification .%“伦理学”已成为后现代哲学的关键词之一,哲学领域中的“伦理学的文学转向”不仅促使当代哲人重新审视伦理学与文学的联系,也促成了文学批评的“伦理转向”。美国最有影响力的哲学家、思想家、反讽哲人理查德·罗蒂在其后形而上学思想中阐明:小说是批判形而上学本质主义与基础主义的有力武器。在公共维度,小说作为社会民主的典型文体,能够有力地揭示人类的残酷之首恶。同时,小说的阅读在为人们提供认识自我和描述自我的新可能性以及激发人类对美好生活的想象上,发挥着关键作用。小说阅读有利于走出自我中心主义,帮助人们认识到生活方式的多样性以及自我和语言的偶然性,在这种意义上,罗蒂倡导小说伦理,并强调小说阅读是当代德性教育和心智教化的最佳方式。

  6. Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the [alpha]I(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid

    Energy Technology Data Exchange (ETDEWEB)

    Wallis, G.A.; Rash, B.; Sweetman, W.A.; Thomas, J.T.; Grant, M.E.; Boot-Handford, R.P. (Univ. of Manchester (United Kingdom)); Super, M. (Royal Manchester Children' s Hospital, Manchester (United Kingdom)); Evans, G. (Robert Jones Orthopaedic Hospital, Oswestry (United Kingdom))

    1994-02-01

    Type X collagen is a homotrimeric, short-chain, nonfibrillar extracellular-matrix component that is specifically and transiently synthesized by hypertrophic chondrocytes at the site of endochondral ossification. The precise function of type X collagen is not known, but its specific pattern of expression suggests that mutations within the encoding gene (COL10A1) that alter the structure or synthesis of the protein may cause heritable forms of chondrodysplasia. The authors used the PCR and the SSCP techniques to analyze the coding and upstream promoter regions of the COL10A1 gene in a number of individuals with forms of chondrodysplasia. Using this approach, they identified two individuals with metaphyseal chondrodysplasia type Schmid (MCDS) with SSCP changes in the region of the gene encoding the carboxyl-terminal domain. Sequence analysis demonstrated that the individuals were heterozygous for two unique single-base-pair transitions that led to the substitution of the highly conserved amino acid residue tyrosine at position 598 by aspartic acid in one person and of leucine at position 614 by proline in the other. The substitution at residue 598 segregated with the phenotype in a family of eight (five affected and three unaffected) related persons. The substitutions at residue 614 occurred in a sporadically affected individual but not in her unaffected mother and brother. Additional members of this family were not available for further study. These results suggest that certain amino acid substitutions within the carboxyl-terminal domain of the chains of the type X collagen molecule cause MCDS. These amino acid substitutions are likely to alter either chain recognition or assembly of the type X collagen molecule, thereby depleting the amount of normal type X collagen deposited in the extracellular matrix, with consequent aberrations in bone growth and development. 36 refs., 5 figs.

  7. 骨靶向药物表阿霉素-氧化葡聚糖-阿仑膦酸钠聚合物的制备及对骨肉瘤细胞的影响%Preparation and effect of bone targeting drug of the epirubicin-oxidized dextran-alendronate compound for osteosarcoma cells

    Institute of Scientific and Technical Information of China (English)

    田大为; 何宏生; 张鹏; 黄晓华; 赵辉; 李刚; 熊敏

    2014-01-01

    Objective To prepare a new bone-targeted drug of epirubicin-oxidized dextran-alendronate compound,and explore the effect of compound on osteosarcoma cells.Methods (1) Based on Schiff's base theory,we synthesized the compound.(2) We investigated physicochemical character with ultraviolet (UV),infrared (IR),and 1H-nuclear magnetic resonance (1H-NMR),molecular weight and aldehyde group content in oxidized dextran,alendronate content in oxidized dextran-alendronate compound,epirubicin drug loading capacity in the compound,and rate of charge for three matters,and affinity to bone in vitro though Hydroxyapatite (HA) absorbing test.(3) We investigated the compound's cytotoxicity effect through methyl thiazolyl tetrazolium (MTT) test,apoptosis influence through flow cytometry (FCM).Results (1) There were typical physicochemical characters.(2) Oxidized dextran molecular weight (MW) was 4 251 ± 68,number of average molecular weight (MN) was 2 551 ± 42,and molecular weight distribution width was 1.78.Aldehyde group content of oxidized dextran was (10.41 ± 0.2)mmol/mg,epirubicin drug loading capacity was (5.28 ± 0.23) %,rate of charge was 5,and 2 ~ 3 between aldehyde group content in oxidized dextran and alendronate (ALN).(3) In the MTT test,epirubicin (EPI)-Dex-ALN,EPI,ALN obviously restrained osteosarcoma cell proliferation,the minimum concentration(μg/ml) was 1,1,and 40; IC50 (μg/ml) of EPI-Dex-ALN,EPI,ALN was 0.142,0.505,0.219; 0.251,0.739,and 0.518; 45.21,27.97,and 18.96 after 24 h,48 h,72 h; in FCM (flow cytometry),apoptosis and necrosis rate of EPI-Dex-ALN,ALN,and Dex was 80.13 ±4.05,97.01 ±2.58,31.53 ±6.9,and 14.01 ±2.51.Conclusions We successfully synthesized a new bone-targeted drug delivery system,which showed better bone affinity in vivo,and kept biological activity with powerful targeted function.%目的 探讨合成骨靶向药物表阿霉素-氧化葡聚糖-阿仑膦酸钠聚合物对骨肉瘤细胞的影响.方法 (1)根据

  8. 普遍性原则与自由原则:康德道德形而上学理念探源%The Principle of Universality and the Principle of Freedom:A Probe into the Origin of Kant”s Metaphysics of Morals

    Institute of Scientific and Technical Information of China (English)

    王腾

    2014-01-01

    The origin of Immanuel Kant”s metaphysics of morals has long been a controversial issue in academic cir-cles.Generally speaking,there are two sources,one being David Hume and the other being Jean-Jacques Rousseau. On the basis of Hume”s“cause and effect relationships"analysis and critique,Kant makes a clear distinction be-tween“nature"and“freedom",providing“turf"for“morals";the“principle of universality"and“the principle of freedom"prosposed in Rousseau”s social contract facilitates Kant”s construction of his metaphysics of morals as to the principle of transcendental pure“moral laws"and“self-determination".Besides Hume and Rousseau,Leibniz is also an important source of Kant”s metaphysics of morals,as his“spontaneity"and“self-determination"of rational soul monads have inspired Kant to come up with his“theory of freedom"of moral metaphysics,which consists of“transcendental freedom"and“practice of freedom".%康德道德形而上学的来源一直是学术界争论的问题。一般认为,康德道德形而上学有两个来源:一是休谟;二是卢梭。康德在对休谟的“因果大原理”分析与批判的基础上明确区分了“自然”与“自由”,从而为“道德”提供“地盘”;卢梭社会契约论展现出来的“普遍性原则”和“自由原则”促成了康德对先验纯粹的“道德法则”与“意志自律”原则的道德形而上学原理建构。除了休谟和卢梭,莱布尼茨也是康德道德形而上学的重要来源,其理性灵魂单子的“自发性”与“自决性”思想开启了康德道德形而上学的“自由”理论---“先验自由”与“实践的自由”。

  9. The Principle of Universality and the Principle of Freedom:A Probe into the Origin of Kant”s Metaphysics of Morals%普遍性原则与自由原则:康德道德形而上学理念探源

    Institute of Scientific and Technical Information of China (English)

    王腾

    2014-01-01

    康德道德形而上学的来源一直是学术界争论的问题。一般认为,康德道德形而上学有两个来源:一是休谟;二是卢梭。康德在对休谟的“因果大原理”分析与批判的基础上明确区分了“自然”与“自由”,从而为“道德”提供“地盘”;卢梭社会契约论展现出来的“普遍性原则”和“自由原则”促成了康德对先验纯粹的“道德法则”与“意志自律”原则的道德形而上学原理建构。除了休谟和卢梭,莱布尼茨也是康德道德形而上学的重要来源,其理性灵魂单子的“自发性”与“自决性”思想开启了康德道德形而上学的“自由”理论---“先验自由”与“实践的自由”。%The origin of Immanuel Kant”s metaphysics of morals has long been a controversial issue in academic cir-cles.Generally speaking,there are two sources,one being David Hume and the other being Jean-Jacques Rousseau. On the basis of Hume”s“cause and effect relationships"analysis and critique,Kant makes a clear distinction be-tween“nature"and“freedom",providing“turf"for“morals";the“principle of universality"and“the principle of freedom"prosposed in Rousseau”s social contract facilitates Kant”s construction of his metaphysics of morals as to the principle of transcendental pure“moral laws"and“self-determination".Besides Hume and Rousseau,Leibniz is also an important source of Kant”s metaphysics of morals,as his“spontaneity"and“self-determination"of rational soul monads have inspired Kant to come up with his“theory of freedom"of moral metaphysics,which consists of“transcendental freedom"and“practice of freedom".

  10. Feature Selection in Detection of Adverse Drug Reactions from the Health Improvement Network (THIN Database

    Directory of Open Access Journals (Sweden)

    Yihui Liu

    2015-02-01

    Full Text Available Adverse drug reaction (ADR is widely concerned for public health issue. ADRs are one of most common causes to withdraw some drugs from market. Prescription event monitoring (PEM is an important approach to detect the adverse drug reactions. The main problem to deal with this method is how to automatically extract the medical events or side effects from high-throughput medical events, which are collected from day to day clinical practice. In this study we propose a novel concept of feature matrix to detect the ADRs. Feature matrix, which is extracted from big medical data from The Health Improvement Network (THIN database, is created to characterize the medical events for the patients who take drugs. Feature matrix builds the foundation for the irregular and big medical data. Then feature selection methods are performed on feature matrix to detect the significant features. Finally the ADRs can be located based on the significant features. The experiments are carried out on three drugs: Atorvastatin, Alendronate, and Metoclopramide. Major side effects for each drug are detected and better performance is achieved compared to other computerized methods. The detected ADRs are based on computerized methods, further investigation is needed.

  11. The Market Order as Metaphysical Loot

    DEFF Research Database (Denmark)

    Schwarzkopf, Stefan

    2012-01-01

    The mechanism through which the ideology of market capitalism emerged has mostly been interpreted as part of an incremental, inevitable, and thus legitimate ousting of theological concepts from a public sphere that became organized around the principles of the Enlightenment as a secular project...... for the mobilization of individual choice as a principle of social organization. The same process was responsible for underpinning the often unjust and illiberal market order with the vision of the world as an ordered and benign kosmos that emerged spontaneously from chaos....

  12. "Humanitas", Metaphysics and Modern Liberal Arts

    Science.gov (United States)

    Tubbs, Nigel

    2014-01-01

    There is a new myth of the heterogeneous that is reducing the concept of humanity to a sinful enlightenment. In this article I investigate the contribution that a renewed understanding of liberal arts education might offer for the idea of a humanist education and for the concept of humanity; and this at a time when not only the concept of humanity…

  13. Heidegger on Assertion, Method, and Metaphysics

    OpenAIRE

    Golob, Sacha

    2013-01-01

    In Sein und Zeit Heidegger makes several claims about the nature of ‘assertion’ [Aussage]. These claims are of particular philosophical interest: they illustrate, for example, important points of contact and divergence between Heidegger’s work and philosophical movements including Kantianism, the early Analytic tradition, and contemporary pragmatism. This article provides a new assessment of one of these claims: the claim that assertion is connected to a ‘present-at-hand’ ontology. I also ind...

  14. Linguistic Knowledge of Reality: A Metaphysical Impossibility?

    OpenAIRE

    Nescolarde Selva, Josué; Usó i Domènech, Josep Lluís; Sabán, Mario Javier

    2014-01-01

    Reality contains information (significant) that becomes significances in the mind of the observer. Language is the human instrument to understand reality. But is it possible to attain this reality? Is there an absolute reality, as certain philosophical schools tell us? The reality that we perceive, is it just a fragmented reality of which we are part? The work that the authors present is an attempt to address this question from an epistemological, linguistic and logical-mathematical point of ...

  15. Physics and metaphysics looks at computation

    CERN Document Server

    Svozil, K

    2005-01-01

    As far as algorithmic thinking is bound by symbolic paper-and-pencil operations, the Church-Turing thesis appears to hold. But is physics, and even more so, is the human mind, bound by symbolic paper-and-pencil operations? What about the powers of the continuum, the quantum, and what about human intuition, human thought? These questions still remain unanswered. With the strong Artificial Intelligence assumption, human consciousness is just a function of the organs (maybe in a very wide sense and not only restricted to neuronal brain activity), and thus the question is relegated to physics. In dualistic models of the mind, human thought transcends symbolic paper-and-pencil operations.

  16. Physics and metaphysics looks at computation

    OpenAIRE

    Svozil, Karl

    2005-01-01

    As far as algorithmic thinking is bound by symbolic paper-and-pencil operations, the Church-Turing thesis appears to hold. But is physics, and even more so, is the human mind, bound by symbolic paper-and-pencil operations? What about the powers of the continuum, the quantum, and what about human intuition, human thought? These questions still remain unanswered. With the strong Artificial Intelligence assumption, human consciousness is just a function of the organs (maybe in a very wide sense ...

  17. The physics and metaphysics of time

    NARCIS (Netherlands)

    Dieks, D.G.B.J.

    2012-01-01

    We review the current situation in the philosophy of time, partly to investigate Michael Dummett’s complaint that the philosophy of physics has become too specialized and technical to be able to communicate with mainstream philosophy. We conclude that the situation in this case is different: there i

  18. Anaesthetic gardens. On Metaphysics by Lech Majewski

    Directory of Open Access Journals (Sweden)

    Marta Baron

    2010-06-01

    Full Text Available Interpretation of Metaphisics – the novel written by Lech Majewski, is the subject matter of theoretical, aesthetic and antropological considerations. Synthesis of arts: literature, film, painting and theatre, which occur in the novel, opens a perspective of intertextuality and provokes questions about ekphrasis, varied materials, ways of experience mediated by dispositives and reflections on humans among other problems. The crucial point in both: Majewski’s novel and this dissertation, is a triptych painted by Hieronymus Bosch – The Garden of Earthly Delight, which gradually annexes the featured world – becomes a basic figure in trying to show, how the aesthetization of reality brings Wolfgang Welsch’s cahegory of an(aesthetics.

  19. Homeopathic tendencies : acts of metaphysical desire.

    OpenAIRE

    Seymour, Carmel Janette, 1979-

    2015-01-01

    Homeopathic Tendencies explores the relationship between creative intuition and the Spiritualist movement. The links between the domestic setting and magical thinking are explored through the invention of ritual in the home, the collecting and animating of objects and the building of domestic shrines. It examines artists that used Spiritualism as a method for making work but also artists that engage with a magical language when describing dealing with uncertainty in their own work. By usi...

  20. The Metaphysical Case against Luck Egalitarianism

    NARCIS (Netherlands)

    W. van der Deijl (Willem)

    2013-01-01

    textabstractLuck egalitarianism is the name of a group of theories of justice that subscribe to the idea that a just society compensates for brute luck, but does not compensate for bad outcomes that fall under the responsibility of the agent himself. The theory has gained much popularity over the pa

  1. A metaphysical journey in a comatose state.

    Science.gov (United States)

    Gimenez, R

    1992-01-01

    This paper is about the intense experience of being in the hospital in a comatose state resulting from an aneurysm with a massive brain hemorrhage and two subsequent surgeries. The event begins with a premonition of what will happen from a street name. The experience of brain surgeries, along with the fine care of the nurses, left me with a truly memorable impression. This paper describes the various feelings and strong emotions that I experienced while in a comatose state. It suggests that a patient in a comatose state can exist in a deep state of emotions close to ecstasy. The paper concludes with gratefulness to all the people who followed me step by step on this journey. PMID:1286457

  2. The metaphysics of laws: dispositionalism vs. primitivism

    CERN Document Server

    Dorato, Mauro

    2014-01-01

    The paper compares dispositionalism about laws of nature with primitivism. It argues that while the distinction between these two positions can be drawn in a clear-cut manner in classical mechanics, it is less clear in quantum mechanics, due to quantum non-locality. Nonetheless, the paper points out advantages for dispositionalism in comparison to primitivism also in the area of quantum mechanics, and of contemporary physics in general.

  3. Analysis on the Images in“The Love Song of J. Alfred Prufrock”from the Metaphysical Poetic Theories’ Perspective%《杰•阿尔弗瑞德•普鲁弗洛克的情歌》中的玄学意象解读

    Institute of Scientific and Technical Information of China (English)

    陈明明

    2013-01-01

    As one of the most important poets and critics of the 20th century in the history of British and American literature, T. S. Eliot had made greatest remarks on the Metaphysical Poetry of the 17th century. In his early poem“The Love Song of J. Alfred Prufrock”, Eliot revealed the loss, confusion and frustration of the modern western men by endowing rich implication to the metaphor and allusion images through the technique of metaphysical conceit.%作为20世纪英美文学史上重要的一位诗人及批评家,T.S.艾略特对17世纪的“玄学派诗歌”推崇备至,在其早期《普鲁弗洛克的情歌》中,诗人借用“玄学奇喻”的技巧赋予大量隐晦的隐喻和典故意象丰富的蕴意,展现了现代西方人的迷惘、困惑及挫败感。

  4. Efeitos de tratamento combinado de alendronato de sódio, atorvastatina cálcica e ipriflavona na osteoporose induzida com dexametasona em ratas Effects of combined treatment of alendronate of sodium, calcic atorvastatin and ipriflavone in osteoporosis induced with dexamethasone in female rats

    Directory of Open Access Journals (Sweden)

    Aloísio da Silva Pinto

    2006-03-01

    Full Text Available O objetivo deste trabalho foi estudar a influência das combinações: bifosfonato (alendronato de sódio + estatina (atorvastatina cálcica, bifosfonato (alendronato de sódio + flavonóide (ipriflavona e estatina (atorvastatina cálcica + flavonóide (ipriflavona em ratas com osteoporose induzida pelo glicocorticóide dexametasona. As influências das associações dessas substâncias foram pesquisadas pela análise de testes dos marcadores bioquímicos de remodelação óssea, tais como, cálcio e fósforo sérico, fosfatase alcalina óssea e por exames histomorfométricos, caracterizando a densidade trabecular óssea. Através da avaliação da densidade trabecular óssea foi possível verificar o aumento da mesma em todos os tratamentos efetuados. Ressaltando-se, ainda, que as associações contendo alendronato de sódio apresentaram elevadas taxas de restauração tecidual óssea, alcançando valores superiores aos do grupo dos animais normais. Os marcadores bioquímicos não apresentaram resultados estatisticamente significativos, não fornecendo subsídios para o diagnóstico e acompanhamento da osteoporose. No entanto, a avaliação histomorfométrica permitiu a análise estática e dinâmica, bem como detecção de alterações teciduais na unidade metabólica óssea, particularmente, no osso trabecular.The objective of this work was to study the influence of the combinations: biphosphonate (alendronate of sodium + statin (calcic atorvastatin, biphosphonate (sodium alendronate + flavonoid (ipriflavone and statin (calcic atorvastatin + flavonoid (ipriflavone in female rats with osteoporosis induced by the glucocorticoid dexamethasone. The influence of the combinations of those drugs was observed through tests of the biochemical markers of bone remodeling, such as, levels of serum calcium and phosphorus and bone alkaline phosphatase and through histomorphometric exam, visualizing the bone trabecular density. Through the evaluation of the

  5. Art as a function of existence——An exploration of Karl Jaspers' idea of metaphysics of existenctial art%作为一种"生存的功能"的艺术——雅斯贝斯"生存艺术形而上学"思想探微

    Institute of Scientific and Technical Information of China (English)

    孙秀昌

    2009-01-01

    Karl Jaspers is devoted to an existential philosophy towards the transcendent dimension. He re-gards art as an organ of philosophy, and forms a peculiar idea of metaphysics of existential art. He takes it for granted that existence is the resource of art. The artistic action brings out the connotation that the art is function of existence.%雅斯贝斯所致力的是一种祈向超越之维的生存哲学,由此视域出发,他把艺术视为"哲学的器官",并提出了一种独具慧心的"生存艺术形而上学"思想.他认为,艺术根源于"生存",艺术活动透示了艺术作为"生存的功能"这一人文意趣.

  6. 阿仑膦酸钠肠溶片预防和治疗绝经后妇女骨质疏松症的相关研究%Study of alendronate sodium enteric-coated tablets in prevention and treatment of osteoporosis in postmenopausal women

    Institute of Scientific and Technical Information of China (English)

    边志颖; 刘丽华; 李彩格; 张力辉; 周红; 张松筠

    2012-01-01

    content level of leptin and Interleukin-6(IL-6) were compared between postmenopausal women (observed group) and normal child-bearing age women (control group) to explore the incidence possibility of osteoporosis;To observe and analyze the efficacy and safety of alendronate sodium enteric-coated tablets in prevention and treatment of osteoporosis in postmenopausal women. Methods The subjects in control group(25 cases) got no treatment, while all postmenopausal women in observed group(42 cases) took Caltrate D 600 mg/d and alendronate sodium enteric-coated tablets 70 mg per week orally in 6 months. Bone mineral density(BMD) and leptin, interleukin-6 level of observed group and control group, BMD of lumbar vertebrae 2-4 (L2-4), left neck of femur. Ward triangle, femoral trochanter, and alkaline phosphatase (ALP), bone gla protein (BGP), tartrate- resistant acid phosphatase (TRAP), calcium (Ca), phosphate (P) before the treatment,in the end of the 6th month and 1 year after the treatment were measured. The relevant indicators of bone metabolism of two groups were compared. Results Compared with control group, the BMD of L2-4 and left femoral neck,femoral trochanter and Ward triangle in observed group reduced significantly( P <0. 01). Serum interleukin-6 in observed group was significantly higher than that of control group,(69. 22±7. 01) μg/L vs (11. 37±4. 86) μg/L( P< 0.01). At the end of the 6th month of the treatment, the BMD of observed group L2-4,left femoral neck, femoral trochanter and Ward triangle increased significantly as compared with that before the treatment( P <0. 05 or <0. 01). L2-4(0. 83±0.08) g/m3 ,(0. 88 + 0. 08) g/m3 vs (0. 87±0. 07) g/m3 ( P <0. 05);left femoral neck(0. 68±0. 11) g/ m3,(0. 72±0. 07) g/m3 vs (0. 73±0. 06) g/m3( P <0. 05);Bone strands of thick long(0. 61 ±0. 09) g/m3,(0. 71 ±0.09) g/m3 vs (0. 69±0.08) g/m3( P <0. 01); Ward triangleCO. 48±0. 13) g/m3, CO. 57±0. 11) g/m3 and (0. 55± 0. 13) g/m3 ( P <0. 01). ALP,BGP,TRAP level

  7. Efficacy of raloxifene in postmenopausal women with osteoporosis after 3 to 5 years treatment failure of alendronate%应用阿仑膦酸钠治疗绝经后骨质疏松失效改用雷洛昔芬的疗效观察

    Institute of Scientific and Technical Information of China (English)

    陈琳; 游利; 陈瑾瑜; 潘凌; 彭永德

    2015-01-01

    症患者骨密度,降低骨转换;应用阿仑膦酸钠治疗3~5年后失效者改用雷洛昔芬可显著减慢骨丢失率。%Objective To observe the efficacy of sequential therapy of raloxifene in postmenopausal women with osteoporosisafter3to5yearstreatmentofalendronate.Methods 240eligiblecasesofpostmenopausalwomenwithoste-oporosis from 11 538 patients selected according to the inclusion criteria in Shanghai first people’s hospital between Octo-ber 2005 and October 2013 were collected.Subjects were divided into two groups (A and B).A group (155 cases):All patients newly initiated treatment with raloxifene.B group (85 cases): Patients with 3 to 5 years failure of alendronate treatment previously were switch to raloxifene.All patients received supplemental calcium and active vitamin D.A retro-spective statistical analysis was performed for basic clinical characteristics, duration of treatment, BTM, BMD and fracture data.Results BMD at lumbar spine, femoral neck and hip in the A group were significantly higher after raloxifene treat-ment for 12 months than that before treatment (t=10.778, P<0.000 1;t=3.587, P<0.000 1;t=7.998, P<0.000 1). The percent changes in BMD at the lumbar spine and femoral neck were 3.3% and 1.5% and 1.4 % ( P<0.05 ) . There was a significant difference in the percent decrease in BGP andβ-CTX at 12 months (t=6.392, P<0.000 1;t=13.078, P<0.000 1).B group switched to raloxifene after 3-5 years of alendronate treatment.BMD at lumbar spine, femoral neck and hip in the sequential therapy group were trend to be higher than that before treatment, but the difference was not statistically significant (t=1.093, P=0.277; t=1.896, P=0.061; t=1.045, P=0.299).No statistically significant difference of annual change rate of BGP andβ-CTX was found after raloxifene treatment than before.However, the percentage changes in the BMD at lumbar spine and femoral neck were significantly higher after raloxifene treatment for 12 months than that before

  8. Rethinking of the Relationship between Marx and Metaphysics ——Review the Heidegger's Criticizing of Marx on the Height of the Nihilism%重新理解马克思与形而上学问题——兼驳海德格尔对马克思“达到了虚无主义的极致”的批评

    Institute of Scientific and Technical Information of China (English)

    宋友文

    2012-01-01

    马克思所创立的历史唯物主义属于世界观理论的谱系,它通过对德意志意识形态的批判终结了传统的形而上学。把作为超感性世界的意识形态归结为感性世界只是马克思克服形而上学的第一步。回应海德格尔对马克思陷入虚无主义的批评,就要回答马克思和“感性世界与超感性世界二元对立”的形而上学结构的关系问题。马克思不只是把超感性世界颠倒、归结为感性世界,而且是诉诸具体的作为感性活动的物质生产的二重性来克服虚无主义问题。感性活动作为感性世界和超感性世界的中介,起着“上通下达”的作用,表征着人的生存方式的二重性和矛盾性。因此,作为世界观理论的历史唯物主义正是通过具体的感性活动在感性世界和超感性世界之间保持了必要的张力,才避免了形而上学与虚无主义的厄运。%Historical materialism established by Marx is by pedigree the theory of worldview, ending the metaphysics by criticizing the German ideology. Marx attributes the transcend world to the sensible world, which is the first step to conquer metaphysics. In order to response to the Heidegger's criticizing of Marx in the nihilism, we must find out the relationship betweefi Marx's philosophy and the duality of transcendental world and sensible world of metaphysics. Marx conquers the nihilism resorts to the duality of the material production as sensible activity. As the medium of the transcendental world and sensible world, the sensible activity represent the duality and contradiction of the mode of human existence. Marx conquer the metaphysics and nihilism by establishing the balance of the transcendental world and sensible world.

  9. Collaborative Improvement

    DEFF Research Database (Denmark)

    Kaltoft, Rasmus

    The thesis data have been collected in the EU-sponsored project: Collaborative Improvement Tool for the Extended Manufacturing Enterprise, CO-IMPROVE. In this project four universities (Denmark, Ireland, Italy, and The Netherlands), two software vendors (Greece and Sweden) and three companies...... learn how to improve operations in (hopefully) a win-win like manner through collaboration....

  10. O darwinismo e o sagrado na segunda metade do século XIX: alguns aspectos ideológicos e metafísicos do debate Darwinism and "the sacred" during the second half of the 19 th century: some ideological and metaphysical features of the debate

    Directory of Open Access Journals (Sweden)

    Juanma Sánchez Arteaga

    2008-01-01

    Full Text Available O artigo analisa alguns aspectos ideológicos e metafísicos da transformação do imaginário ocidental sobre a origem da espécie humana - a velha questão, "quem somos?", respondida de formas diversas pelo cristianismo e pela biologia evolutiva - na segunda metade do século XIX. Nesse período passa-se do predomínio da antropogênese cristã ao das explicações evolucionistas. Analisa-se a confrontação histórica que teve lugar, nesse período, entre alguns dos principais defensores científicos do evolucionismo materialista - Haeckel, Clémence Royer e Huxley - e os defensores de uma antropologia anti-evolucionista e cristã. Analisam-se brevemente os pontos principais da crítica de Darwin à religião e algumas similitudes e discrepâncias de sua crítica ao pensamento religioso com relação à realizada por Marx no mesmo período. Determinados aspectos ideológico-metafísicos foram componentes essenciais do discurso darwinista na sua luta para se impor às narrativas do cristianismo sobre a origem do ser humano.This paper analyzes some of the ideological and metaphysical features of the historical transformation of Western imaginary on human origins, during the second half of 19th Century. In this period, predominance of the Christian Natural Theology accounts about anthropogenesis gave place to a new paradigm, based on evolutionary biological explanations. We thus analyze the historical confrontation that took place between prominent materialistic scientists - Haeckel, Royer, Huxley - defending evolutionary theories, on one hand, and advocates of a non-evolutionist anthropology linked to Christian believe in Creation, on the other. This paper analyzes the main features of Darwin's criticism of religious thought, based on naturalistic basis, and presents some similarities and differences with the critique of religion made by Marx in the same period. Darwinism included some metaphysical and ideological elements as essential parts of

  11. Long-Term Alendronate Use Not without Consequences?

    Directory of Open Access Journals (Sweden)

    M. P. Somford

    2009-01-01

    Full Text Available A previously unknown side effect of biphosphonate use is emerging. In a specific patient group on long term biphosphonate therapy stress femur fractures seem to occur. The typical presentation consists of prodromal pain in the affected leg and/or a discrete cortical thickening on the lateral side of the femur in conventional radiological examination or the presentation with a spontaneous transverse subtrochanteric femur with typical features. We present three cases of this stress fracture in patients on bisphosphonate therapy. One of these patients suffered a bilateral femur fracture of the same type. In our opinion, in patients on bisphosphonate therapy who present with a spontaneous femur fracture, seizing therapy is advisable. In bilateral cases preventive nailing should be considered.

  12. 天才的“形而上”痛苦--论死亡忧患对李贺及其诗歌的影响%The Metaphysical Misery of Genius---To Discuss the Influence of Death's Suffering on Li He and his Poetry

    Institute of Scientific and Technical Information of China (English)

    马涛

    2013-01-01

    Under the oppression of death ,young Li He suffered the lapse of time .His poem expressed a kind of metaphysical anxiety and confusion about life and time .All of these made him spontaneously think about the questions of perpetuity and perdition ,enjoyment and death ,paradise and hell .Li He and his poetry were affected by anxiety of death directly .%  在死亡的压迫下,李贺以青春的生命负荷着极为深沉的年命之悲,表达出一种对生命和时间的“形而上”的焦虑与迷惘。这使他很自然地去思考永恒与毁灭,享乐与死亡,天国与地狱等这些“形而上”的问题。“死亡忧患”直接影响了李贺的诗歌创作。

  13. 形而上的“价值”与形而下的“用法”——索绪尔与后期维特根斯坦意义理论比较研究%Metaphysical Value and Physical Usage:A Study of Meaning Theory between Saussure and Post-Wittgenstein

    Institute of Scientific and Technical Information of China (English)

    刘艳茹

    2012-01-01

    在西方哲学的语言转向中,索绪尔和维特根斯坦在语言哲学领域中分别作出了不同贡献。在意义理论中,两者既有相同之处,也有相异之处。相同之处在于二者都提出了对命名论的批判、都恪守整体主义的意义观,相异之处在于二者对于判定意义的标准不同,索绪尔提出了形而上的"价值"决定论,维特根斯坦提出了形而下的"用法"决定论,而二者意义观的不同是他们语言观差异的体现。%In the linguistic turn of western philosophy,Saussure and Wittgenstein did great contribution on philosophy of language.Both of them made similarities and dissimilarities on meaning theory.The similarities lie in the criticism on naming theory and observation of holism while the dissimilarities rest with the distinctive standards on criticizing meaning.Saussure advances value-determinism from metaphysical aspect on the contrary Wittgenstein advances usage-determinism from physical aspect.Their distinctive views on meaning are decided by their different outlooks on language.

  14. 王弼形而上哲学的现实关怀--会通“名教”与“自然”关系的尝试%On Wang Bi’s Metaphysical Philosophy:Trying to Recombine the Confucian Ethical Code with Nature

    Institute of Scientific and Technical Information of China (English)

    宋颖

    2014-01-01

    The relation between the Confucian ethical code and Nature is the key to solving the problem of Weijin scholars’ life tragedy and also the core of metaphysics in Wei and Jin Dynasties. Lao Zhuang’s“WU”is promoted to a purer ontology in Wang Bi’s philosophy. Based on the upgraded“WU”,“Nature”is transcended;a clear relationship between“WU”,“XING”and“li”is discussed;and the connotation of “Nature” is given personal emotion and social culture. And thus the Confucian ethical code can be proved reasonably. All of these lay the theoretical foundation of Weijin scholar’s poeticizing realm of life to eliminate their consciousness of tragedy.%名教与自然的关系问题,是如何解决魏晋士人现实生存悲剧性的核心问题,也是魏晋玄学的核心问题。王弼在把老庄的“无”提升为更纯粹的本体论基础上,赋予“自然”以超越的境界旨趣,并论述自然与“无”“性”“理”的关系,扩大了道家的“自然”概念,赋予“自然”人的情感和社会文化的新内涵,使得现实的“名教”有了合理根据,为弥合悲剧意识的魏晋士人诗化人生境界的出现奠定了理论基础。

  15. Effect of T-2 toxin on growth and development of rat knee epiphyseal plate and metaphyseal bone in normal and low nutritional status%T-2毒素在正常和低营养状态下对大鼠膝关节骺板及干骺端骨组织生长发育的影响

    Institute of Scientific and Technical Information of China (English)

    姚运峰; 康鹏德; 李兴波; 杨静; 沈彬; 周宗科; 裴福兴

    2010-01-01

    异有统计学意义(P均<0.01).结论 在正常营养状态下,T-2毒素可导致大鼠骺板软骨肥大层细胞坏死,骺板胶原含量降低,干骺端骨小梁形成障碍;在低营养状态下,T-2毒素可导致大鼠骺板细胞坏死和于骺端成骨障碍更为显著,但这种表现是否与大骨节病的发生有关,还有待研究.%Objective To observe the effect of T-2 toxin on growth and development of rat epiphyseal plate of left knee and metaphyseal bone of femur and tibia in normal and low nutritional status, to find out possible pathogenic factors of Kashin-Beck disease and provide experimental basis for early intervention. Methods Ninety 3-week-old Wistar rats, weighing 60 - 70 g, were randomly divided into three groups: control group(general feed), T-2 toxin + general feed group, T-2 toxin + low nutrition feed group, thirty rats in each group with equally sex ratio. T-2 toxin (1.0 mg/kg) was administered orally 5 times a week via a gavage needle for 4 weeks. The change of hair, activity and body weight was observed. After 1, 2, 4 weeks, the epiphyseal plate of left knee and metaphyseal bone of femur and tibia (including distal femur and proximal tibia) were collected. Specimens were processed with HE and Masson staining. The morphology of chondrocytes and matrix collagen content in epiphyseal plate was observed. Trabecular bone volume fraction in tibial metaphyseal bone was analyzed by Image-Pro Plus 6.0 software. Results In the control group, rats were in good movement and hair with light, but in T-2 toxin + general feed group and T-2 toxin + low nutrition feed group, rats were found with reduced activities and hair with dark color. Body weights(g) of the control group, the T-2 toxin + general feed group and the T-2 toxin + low nutrition feed group were 81.0 ± 6.2, 79.0 ±5.1, 77.0 ± 7.5, respectively, by the end of first week; 101.8 ± 6.7, 97.0 ± 6.8, 93.0 ± 5.3, respectively, by the end of second week; 151.1 ± 15.7, 126.5 ± 11.9, 106.5 ± 11.5, respectively

  16. 科学公理、感性经验与知识层理化--“科玄论战”中的美学问题%Scientific Axioms, Perceptual Experience and Differentiation of Knowledge:The Aesthetic Issues in the"Controversy between Science and Metaphysics"

    Institute of Scientific and Technical Information of China (English)

    徐一超

    2014-01-01

    近现代科学主义思潮具有知识、认识论与伦理道德等价值范畴的一体性,它的发展以及对它的质疑催生了“科玄论战”。在论争过程中,基于感性经验的美学范畴被与科学范畴相区别,美学知识体系内部的美、美学等概念也被加以区分,这可以被视作一个“知识层理化”的过程,是现代性生成背景下知识分化与转型的重要体现。而在形式层面,貌似学术讨论的论战文本事实上呈现出基于感性经验的修辞特征与俗化的美学风格,“论理”过程本身其实是“乏理”的,这也是考察“科玄论战”中美学问题的一个视角。%Scientism in modern China is characterized by the fusion of knowledge, epistemology and value categories exem-plified by ethics and morality, and its development, as well as the queries about it, gave birth to the"Controversy between Science and Metaphysics"in 1923.During the debate, the aesthetic categories based on perceptual experience were differen-tiated from the scientific ones, and the concepts belonging to the aesthetic knowledge system such as beauty and aesthetics were also distinguished from each other.This process of knowledge differentiation can be seen as an important modern trans-formation against the background of the emergence of modernity.As for the form of text, the articles in the controversy made use of meaningful rhetoric intertwined with perceptual experience and laymen's style, even though they seemed to be academic and scholastic.

  17. 试论康德道德形而上学德性论的“建筑术”--兼与亚里士多德幸福论德性论“建筑术”比较%On Kantian Architectonic in Metaphysics of Ethics In Comparison with Aristotelian Architectonic in Eudemonia of Aretaic Ethics

    Institute of Scientific and Technical Information of China (English)

    陈晓曦

    2014-01-01

    Architectonic question plays an important role in Kantian thinking system.The architectonic which Kant understood is the rational framework a priori.Through the enquiry into how his whole thinking system is deducted and reasoned,the architectonic thread can be ascertained;and through basic notions and argument in his moral metaphysical virtues,the architectonic development investigated. Also,there exists another architectonic in Aristotelian ethics.By comparison,a deeper understanding will come into being. Kantian virtue is morality architectonic,however,Aristotelian teleology architectonic.Thus,distinctions of moral consciousness structure are:the former means that the ontology of virtue lies in action for the sake of moral only,and the later means a state involving rational choice,consisting in a mean relative to us and determined by reason(logos).%建筑术(architectonic)的问题在康德整个思想体系一直都是重要的。康德所理解的建筑术是一种理性的先天架构。从康德全部思想体系中的先天思想如何层层演绎和推理角度,可以探究其思想建筑术的线索;从康德德性论道德形而上学基本概念和论证出发,可以考察其建筑术之运思。亚里士多德幸福论的德性论中也存在建筑术,通过比较亚里士多德与康德建筑术,可以深化对两种德性论建筑术及其道德意识结构的理解。康德的德性论建筑术是一种道德性的建筑术,德性论中道德意识结构,即德行(Tugend)的存有论是行动出于德性(Sittlichkeit);而亚氏的则属于目的性的建筑术,德性论中的道德意识结构则是灵魂合于逻各斯的中道选择。

  18. The Production of Seriousness The Metaphysics of Economic Reason

    CERN Document Server

    Gustafsson, Professor Emeritus Claes

    2011-01-01

    This book is about the roots of managerial rationality. A theoretical base, founded on the concept of 'memetics' is developed in order to explain human thinking and human reason as products of cultural evolution. Cultural change and development are explained by simple, value-driven memetic mechanisms like 'ritualization' and 'extremization'.

  19. Cognitive Metaphor Theory and the Metaphysics of Immediacy

    Science.gov (United States)

    Madsen, Mathias W.

    2016-01-01

    One of the core tenets of cognitive metaphor theory is the claim that metaphors ground abstract knowledge in concrete, first-hand experience. In this paper, I argue that this grounding hypothesis contains some problematic conceptual ambiguities and, under many reasonable interpretations, empirical difficulties. I present evidence that there are…

  20. Infanticide for handicapped infants: sometimes it's a metaphysical dispute.

    OpenAIRE

    Long, T A

    1988-01-01

    Since 1973 the practice of infanticide for some severely handicapped newborns has been receiving more open discussion and defence in the literature on medical ethics. A recent and important argument for the permissibility of infanticide relies crucially on a particular concept of personhood that excludes the theological. This paper attempts to show that the dispute between the proponents of infanticide and their religious opponents cannot be resolved because one side's perspective on the infa...

  1. Mirror neurons: Enigma of the metaphysical modular brain.

    Science.gov (United States)

    Acharya, Sourya; Shukla, Samarth

    2012-07-01

    Mirror neurons are one of the most important discoveries in the last decade of neuroscience. These are a variety of visuospatial neurons which indicate fundamentally about human social interaction. Essentially, mirror neurons respond to actions that we observe in others. The interesting part is that mirror neurons fire in the same way when we actually recreate that action ourselves. Apart from imitation, they are responsible for myriad of other sophisticated human behavior and thought processes. Defects in the mirror neuron system are being linked to disorders like autism. This review is a brief introduction to the neurons that shaped our civilization.

  2. THE CONCEPT OF SENCE IN THE WORLD, METAPHYSICS AND SCIENCE

    Directory of Open Access Journals (Sweden)

    Michal Sicinski

    2007-01-01

    Full Text Available The notion of objective sense is commonly used in various contexts, and is also frequently misused. It has been often criticised in the context of natural sciences during the last 200 years - the period of positivistically oriented science. In the ancient Greek philosophy the problem of Nature possessing its own sense was stressed, and from the problem the first germs of science started in the Ionic and Pythagorean schools. Contrary to that, Aristotelean approach initiated the positivist tradition which banned from science the question of Nature as possessing an internal sense, and the scholastics introduced a concept of Nature's sense being not intrinsic but granted to it by the divine action. The mathematisation of physics caused that the the divine action started to be interpreted as "mathematical", and in consequence, the sense of Nature was seen as expressed by mathematics. Later on, this mathematically expressed sense of Nature, as seen in physical theories, started to be perceived as independent from God and having not much to as supernatural: inside the mathematical science there was no place for any anthropomorphic Creators.Recently, however when in the newest physics the mathematical structures have already been perceived not only as a language but also as a kind of ultimate reality, a place for quasi-religious feeling of mystery hidden in these structures has been welcome. It means that within the field of modern physical theories there is no place for the traditional religious concepts, but there is a place for a kind of mystics of objective mathematics in the Pythagorean style, related to the modern "new spirituality" mysticism.The situation is completely different in the area of less mathematised branches like biology. The tensions between science and religion are strong there, and the alternative is as follows: traditional religiousness versus traditional atheism, but not a neutral science separated from religion versus a non-traditional mysticism of the mathematics beings united with nature, as it is in the case of newest physics. So, the biologist who are not ready to accept the popular tradition notion of God directly interfering with nature, e.g. creating the phenomenon of life or man, are ready to accept the old-fashioned "scientific" atheism. That is why the dialogue science and religion is rather difficult in relation to biology, despite being so fruitful in relation to physics and cosmology.

  3. The "Spiritual Handshake": Toward a Metaphysical Sustainability Metrics

    Science.gov (United States)

    Beringer, Almut

    2007-01-01

    Is it feasible and appropriate to develop a sustainability metrics which captures cosmological-spiritual dimensions of un/sustainability? Departing from the supposition that the crisis of unsustainability is a crisis of worldview and misguided cosmology which needs redirection on a cultural and global scale, this essay introduces the notion of a…

  4. Pursuing the Good, Ethics and Metaphysics in Plato s Republic

    Institute of Scientific and Technical Information of China (English)

    Douglas; Cairns; Fritz-Gregor; Herrmann; Terry; Penner

    2008-01-01

    ‘Pursuing the good’ is an old subject in both social history of ancient Greece and Greek philosophy studies. There is hardly anything new when we talk about virtue or morality in the time of Plato and Aristotle. In the area of Greek history, many books and articles on or relevant to that

  5. Humanities’ Metaphysical Underpinnings of Late Frontier Scientific Research

    Directory of Open Access Journals (Sweden)

    Alcibiades Malapi-Nelson

    2014-12-01

    Full Text Available The behavior/structure methodological dichotomy as locus of scientific inquiry is closely related to the issue of modeling and theory change in scientific explanation. Given that the traditional tension between structure and behavior in scientific modeling is likely here to stay, considering the relevant precedents in the history of ideas could help us better understand this theoretical struggle. This better understanding might open up unforeseen possibilities and new instantiations, particularly in what concerns the proposed technological modification of the human condition. The sequential structure of this paper is twofold. The contribution of three philosophers better known in the humanities than in the study of science proper are laid out. The key theoretical notions interweaving the whole narrative are those of mechanization, constructability and simulation. They shall provide the conceptual bridge between these classical thinkers and the following section. Here, a panoramic view of three significant experimental approaches in contemporary scientific research is displayed, suggesting that their undisclosed ontological premises have deep roots in the Western tradition of the humanities. This ontological lock between core humanist ideals and late research in biology and nanoscience is ultimately suggested as responsible for pervasively altering what is canonically understood as “human”.

  6. Social Darwinism, Scientific Racism, and the Metaphysics of Race.

    Science.gov (United States)

    Dennis, Rutledge M.

    1995-01-01

    Maintains that science is often used as a justification to propose, project, and enact racist social policies. The philosophy of Social Darwinism is reviewed, and its assumptions about race and human abilities is discussed. The consequences of scientific racism for dominant groups are analyzed. (GR)

  7. Cognitive Metaphor Theory and the Metaphysics of Immediacy.

    Science.gov (United States)

    Madsen, Mathias W

    2016-05-01

    One of the core tenets of cognitive metaphor theory is the claim that metaphors ground abstract knowledge in concrete, first-hand experience. In this paper, I argue that this grounding hypothesis contains some problematic conceptual ambiguities and, under many reasonable interpretations, empirical difficulties. I present evidence that there are foundational obstacles to defining a coherent and cognitively valid concept of "metaphor" and "concrete meaning," and some general problems with singling out certain domains of experience as more immediate than others. I conclude from these considerations that whatever the facts are about the comprehension of individual metaphors, the available evidence is incompatible with the notion of an underlying conceptual structure organized according to the immediacy of experience. PMID:26523770

  8. Descriptive Metaphysics, Natural Language Metaphysics, Sapir-Whorf, and All That Stuff: Evidence from the Mass-Count Distinction

    OpenAIRE

    Francis Jeffry Pelletier

    2010-01-01

    Strawson (1959) described ‘descriptive metaphysics’, Bach (1986a) described ‘natural language metaphysics’, Sapir (1929) and Whorf (1940a,b, 1941) describe, well, Sapir-Whorfianism. And there are other views concerning the relation between correct semantic analysis of linguistic phenomena and the “reality” that is supposed to be thereby described. I think some considerations from the analyses of the mass-count distinction can shed some light on that very dark topic.ReferencesBach, Emmon. 1986a...

  9. CDBG Public Improvements Activity

    Data.gov (United States)

    Department of Housing and Urban Development — CDBG activity related to public improvements, including senior centers, youth centers, parks, street improvements, water/sewer improvements, child care centers,...

  10. Quality improvement techniques to improve patient satisfaction.

    Science.gov (United States)

    Torres, E Joseph; Guo, Kristina L

    2004-01-01

    This paper describes several approaches for implementing quality improvement initiatives to improve patient satisfaction, which enables health-care organizations to position themselves for success in today's global and increasingly competitive environment. Specifically, measuring the views of patients, improving patient satisfaction through a community-wide effort, and using a Six Sigma program are discussed. Each of these programs can be an effective mechanism for quality improvement. A key component to quality improvement techniques involves collaborative efforts by all health-care professionals and managers as they seek to increase patient satisfaction. PMID:15552388

  11. Theme: Laboratory Facilities Improvement.

    Science.gov (United States)

    Miller, Glen M.; And Others

    1993-01-01

    Includes "Laboratory Facilities Improvement" (Miller); "Remodeling Laboratories for Agriscience Instruction" (Newman, Johnson); "Planning for Change" (Mulcahy); "Laboratory Facilities Improvement for Technology Transfer" (Harper); "Facilities for Agriscience Instruction" (Agnew et al.); "Laboratory Facility Improvement" (Boren, Dwyer); and…

  12. Mistik ve Metafizik Bağlamda Bir Yolculuk Üçlemesi: “Hüsn ü Aşk - Hacının Yolu - Simyacı” A Journey Trilogy In The Context Of Mystic And Metaphysic “Hüsn ü Aşk - The Pilgrim’s Progress - The Alchemist”

    Directory of Open Access Journals (Sweden)

    Nazire ERBAY

    2013-03-01

    Full Text Available Journey is a mystical action in which a person goes through a metaphysical experience regardless of his physical existence even though it has just a meaning of a usual moving in time and place. The journey that brings the individual to maturity and tranforms/changes him is quite dangerous and challenging one. In this study, acomparative analysis has been carried out on the factors that make thecharacters who constitute the central idea in the works called ‘Hüsn üAşk’ by Şeyh Galip, ‘The Pilgrim’s Progress’ by John Bunyan and ‘TheAlchemist’ by Paulo Coelho set out an esoteric journey andmutual/different symbols that are used in these three works duringthat journey, characters in the role of helper, obstacles encounteredduring the journey and the goals that the characters eventually achieveat the end of their journeys and meanings of these goals. During thejourney conveyed by the dream metaphor in the three works,individual’s transformation and growing into maturity after witnessingand commenting on the symbolic messages faced in order to findmeaning in life is narrated. Awareness of the transformation isn’tgained by another person; rather it is gained by the individual himself.The enduring journey, as can be seen as learning process, is conveyedby numerous events and situations experienced by the characters in theworks, and each book’s distinctive symbols and images with their ownmeanings. It is important that the heroes make out the omens facedand get over the obstacles and be aware of their own realities. In thethree works of three different cultures, The Pilgrim’s Progress, TheAlchemist, Hüsn-ü Aşk, the heroes similarly undergo a transformationand achieve the endless happiness by overcoming symbolic obstacles. Yolculuk, zaman ve mekân içinde her ne kadar sıradan bir yer değiştirme anlamı taşısa da, mistik anlamda, insanın mevcut varlığını bir tarafa bırakıp metafizik bir tecrübe yaşamasıdır.

  13. The Gendered Metaphysics of Puritan Culture:Towards an Interpretive Explanation of the Salem Witch Trials%清教文化的性别形而上学:对萨勒姆审巫案的诠释性解释

    Institute of Scientific and Technical Information of China (English)

    伊萨克·里德; 童韵评(译)

    2015-01-01

    ,in terms of its points of tension and controversy:the place of women in society,the relationship of the Colony to God, and metaphysical beliefs abort of how the world worked (e.g.witchcraft and spell-casting).This investigation of the Salem Witch Trials raises qrestions abort crltrre, interpretation,and sociological explanation.In answer to these qrestions,the paper srggests that explanations in crltrral sociology:(1 )inclrde,brt also move beyond, the stated intentions,consciors and spoken meanings,and strategic manervers of actors;(2 )consider the intersection of symbolic strrctrres with political economy, brt do not redrce the former to the latter;and (3 )that the direction that a crisis or event takes is intertwined with the interpretation of that crisis by those participating in it. This srggests, then, that crltrral sociology transcends the longstanding distinction between rnderstanding and explanation, offering instead a carsal hermenertics of social life.

  14. Bioequivalence of Alendronate and Vitamin D3 in a Combination Tablet Versus Corresponding-Dose Individual Tablets in Healthy Taiwanese Volunteers, Determined Using a Novel Plasma Alendronate Assay

    Directory of Open Access Journals (Sweden)

    D. Hamish Wright, PhD

    2015-12-01

    Conclusions: The combination tablet was considered bioequivalent to coadministration based on ALN AUC0–∞ and unadjusted vitamin D3 parameters. Slight differences for ALN AUC0–last and Cmax (upper 90% CIs outside the bounds were not considered clinically significant. The combination tablet was well tolerated. No serious adverse experiences were reported. © 2015. The Authors. Published by Elsevier Inc. All rights reserved.

  15. Improving Your Game.

    Science.gov (United States)

    Waggoner, Tom; Bredar, Randy

    2001-01-01

    Discusses ways a new athletic training facility can do more than just improve school sports programs. Explores the new facility's ability to increase functional and operational efficiencies, improve student academic performance, and recruit athletes. (GR)

  16. Improving America's Schools.

    Science.gov (United States)

    Joyce, Bruce R.

    This book presents an argument for school improvement and explains how it might be conducted. Three stages of evolutionary school improvement are identified and described: refinement, renovation, and redesign. It is suggested that the real task is not only innovating improvements; the real task is uniting teachers, administrators, and community…

  17. Improved technical specifications

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, D.R.

    1994-12-31

    Improved technical specifications for nuclear power plants are outlined. The objectives of this work are to improve safety, provide a clearer understanding of safety significance, and ease NRC and industry administrative burdens. Line item improvements, bases, and implementation of the specifications are discussed.

  18. Improving assisted living care.

    Science.gov (United States)

    Gregory, Nancy; Gesell, Sabina B; Widmer, Tom

    2007-01-01

    In the absence of a national measurement system, private vendors of satisfaction measurement and improvement services have played a crucial role in the quality movement in the assisted living industry. Survey responses from 175 resident-family dyads at 20 facilities were analyzed to identify priorities for service improvement from the customers' perspective. They include improving care provided by aides and management, meal service, and activities. Practical solutions for addressing these issues are presented.

  19. Software Process Improvement Defined

    DEFF Research Database (Denmark)

    Aaen, Ivan

    2002-01-01

    This paper argues in favor of the development of explanatory theory on software process improvement. The last one or two decades commitment to prescriptive approaches in software process improvement theory may contribute to the emergence of a gulf dividing theorists and practitioners....... It is proposed that this divide be met by the development of theory evaluating prescriptive approaches and informing practice with a focus on the software process policymaking and process control aspects of improvement efforts...

  20. Ergonomic Improvements for Foundries

    Energy Technology Data Exchange (ETDEWEB)

    Frank Peters; Patrick Patterson

    2002-06-18

    The goal of this project was to make improvements to the production systems of the steel casting industry through ergonomic improvements. Because of the wide variety of products, the wide range of product sizes, and the relatively small quantities of any particular product, manual operations remain a vital part of the production systems of the steel casting companies. Ergonomic improvements will assist the operators to more efficiently and consistently produce quality products.

  1. Process Improvement Essentials

    CERN Document Server

    Persse, James R

    2006-01-01

    Process Improvement Essentials combines the foundation needed to understand process improvement theory with the best practices to help individuals implement process improvement initiatives in their organization. The three leading programs: ISO 9001:2000, CMMI, and Six Sigma--amidst the buzz and hype--tend to get lumped together under a common label. This book delivers a combined guide to all three programs, compares their applicability, and then sets the foundation for further exploration.

  2. Tree Improvement Glossary

    DEFF Research Database (Denmark)

    Schmidt, Lars Holger

    Forest tree improvement encompasses a number of scientific and technical areas like floral-, reproductive- and micro-biology, genetics breeding methods and strategies, propagation, gene conservation, data analysis and statistics, each area with a comprehensive terminology. The terms selected...... for definition here are those most frequently used in tree improvement literature. Clonal propagation is included in the view of the great expansion of that field as a means of mass multiplication of improved material....

  3. THE IMPROVED XINANJIANG MODEL

    Institute of Scientific and Technical Information of China (English)

    LI Zhi-jia; YAO Cheng; KONG Xiang-guang

    2005-01-01

    To improve the Xinanjiang model, the runoff generating from infiltration-excess is added to the model.The another 6 parameters are added to Xinanjiang model.In principle, the improved Xinanjiang model can be used to simulate runoff in the humid, semi-humid and also semi-arid regions.The application in Yi River shows the improved Xinanjiang model could forecast discharge with higher accuracy and can satisfy the practical requirements.It also shows that the improved model is reasonable.

  4. Continuous Personal Improvement.

    Science.gov (United States)

    Emiliani, M. L.

    1998-01-01

    Suggests that continuous improvement tools used in the workplace can be applied to self-improvement. Explains the use of such techniques as one-piece flow, kanban, visual controls, and total productive maintenance. Points out misapplications of these tools and describes the use of fishbone diagrams to diagnose problems. (SK)

  5. Improving palliative care.

    LENUS (Irish Health Repository)

    Moran, Sue

    2009-05-01

    Any service improvement project requires planning, action and evaluation. Using a recognised quality improvement framework can offer a structured approach to implementing and assessing changes to patient care. This article describes how use of the Deming Cycle has helped to identify nurses\\' learning needs.

  6. Improving your oral English

    Institute of Scientific and Technical Information of China (English)

    Kylafree

    2005-01-01

    The most common question my students ask is ""How can I improve my oral English?"" My answer is always the same: practice. There is no quick way to learn another language. You cannot magically learn new words and have perfect pronunciation. The only way to improve is with practice and patience.

  7. Continuous quality improvement

    NARCIS (Netherlands)

    Rohlin, Madeleine; Schaub, Rob M.H.; Holbrook, Peter; Leibur, Edvitar; Lévy, Gérard; Roubalikova, Lenka; Nilner, Maria; Roger-Leroi, Valerie; Danner, Gunter; Iseri, Haluk; Feldman, Cecile

    2002-01-01

    Versch. in: Eur J Dent Educ; 6 (Suppl. 3): 67–77 Continuous quality improvement (CQI) can be envisaged as a circular process of goal-setting, followed by external and internal evaluations resulting in improvements that can serve as goals for a next cycle. The need for CQI is apparent, because of pub

  8. Automated Student Model Improvement

    Science.gov (United States)

    Koedinger, Kenneth R.; McLaughlin, Elizabeth A.; Stamper, John C.

    2012-01-01

    Student modeling plays a critical role in developing and improving instruction and instructional technologies. We present a technique for automated improvement of student models that leverages the DataShop repository, crowd sourcing, and a version of the Learning Factors Analysis algorithm. We demonstrate this method on eleven educational…

  9. Improved nonlinear prediction method

    Science.gov (United States)

    Adenan, Nur Hamiza; Md Noorani, Mohd Salmi

    2014-06-01

    The analysis and prediction of time series data have been addressed by researchers. Many techniques have been developed to be applied in various areas, such as weather forecasting, financial markets and hydrological phenomena involving data that are contaminated by noise. Therefore, various techniques to improve the method have been introduced to analyze and predict time series data. In respect of the importance of analysis and the accuracy of the prediction result, a study was undertaken to test the effectiveness of the improved nonlinear prediction method for data that contain noise. The improved nonlinear prediction method involves the formation of composite serial data based on the successive differences of the time series. Then, the phase space reconstruction was performed on the composite data (one-dimensional) to reconstruct a number of space dimensions. Finally the local linear approximation method was employed to make a prediction based on the phase space. This improved method was tested with data series Logistics that contain 0%, 5%, 10%, 20% and 30% of noise. The results show that by using the improved method, the predictions were found to be in close agreement with the observed ones. The correlation coefficient was close to one when the improved method was applied on data with up to 10% noise. Thus, an improvement to analyze data with noise without involving any noise reduction method was introduced to predict the time series data.

  10. Improvement on GM models

    Institute of Scientific and Technical Information of China (English)

    党耀国; 刘思峰; 刘斌

    2004-01-01

    Since grey system theory was established by prof. Deng, GM models and their improvements have all taken the first vector of the original sequence as the initialization, which resulted to deficiency in making use of the latest infor-mation. Based on the principle, which new information should be used fully, we think it is scientific to pay more atten-tion to the new information or endow them a more weigh. So, this paper deals with the GM improvement by taking the n-th vector as the initialization, and gets great improvement in forecasting precision. Last, we validate the practicability and reliability of the moelds with examples.

  11. IMPROVING PATIENT SAFETY:

    DEFF Research Database (Denmark)

    Bagger, Bettan; Taylor Kelly, Hélène; Hørdam, Britta

    2013-01-01

    Improving patient safety is both a national and international priority as millions of patients Worldwide suffer injury or death every year due to unsafe care. University College Zealand employs innovative pedagogical approaches in educational design. Regional challenges related to geographic...

  12. Improving Agile Software Practice

    DEFF Research Database (Denmark)

    Tjørnehøj, Gitte

    2006-01-01

    Software process improvement in small and agile organizations is often problematic, but achieving good SPI-assessments can still be necessary to stay in the marked or to meet demands of multinational owners. The traditional norm driven, centralized and control centered improvement approaches has...... agile and innovative, while striving for certification according to traditional rational SPI norms? This paper reports from a action research project in a small agile Danish firm (Techsoft) conducting a improvement initiative. The firm had just been met by the demand for a CMMI level-3 certification...... from their new multinational owners. In the project we experimented to reach a less centralized and control centered SPI approach trying to meet the agile culture of the firm both within diagnosing, improvement planning, process design and evaluation eventhough the goal was applying to the norm. After...

  13. Improving combustion efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Bulsari, A.; Wemberg, A.; Multas, A. [Nonlinear Solutions Oy (Finland)

    2009-06-15

    The paper describes how nonlinear models are used to improve the efficiency of coal combustion while keeping NOx and other emissions under desired limits in the Naantali 2 boiler of Fortum Power and Heat Oy. 16 refs., 6 figs.

  14. Driving collaborative improvement processes

    OpenAIRE

    Middel, Rick; Gieskes, José; Fisscher, Olaf

    2002-01-01

    Continuous Improvement is a consolidated concept in theory and practice, mainly in the context of stand-alone companies. However, the battlefield of competition is increasingly moving from the level of individual firms to that of organisational settings based on loose company boundaries and collaborative relations among different units, such as the Extended Manufacturing Enterprises (EMEs). The concept of continuous improvement has hardly been applied in inter-organisational settings. The pur...

  15. An Improved Antihydrogen Trap

    OpenAIRE

    Kalra, Rita Rani

    2015-01-01

    The recent demonstration of trapped atomic antihydrogen for 15 to 1000 seconds is a milestone towards precise spectroscopy for tests of CPT invariance. The confinement of a total of 105±21 atoms in a quadrupole magnetic trap was made possible by several improved methods. Improved accumulation techniques give us the largest numbers of constituent particles yet: up to 10 million antiprotons and several billion positrons. A novel cooling protocol leads to 3.5 K antiprotons, the coldest ever obse...

  16. Improving Communication in Design

    DEFF Research Database (Denmark)

    Maier, Anja; Doenmez, Denniz; Hepperle, Clemens;

    2011-01-01

    Communication permeates every aspect of an engineer’s work – from clarifying product specifications to shaping social ties. This paper offers an overview of recommendations from literature to improve communication within and among engineering teams. We assume communication problems are often...... of tasks. To improve these factors in order to enable effective communication, this paper collates more than hundred recommendations from journal articles and textbooks published in the fields of engineering design, management science, sociology, and psychology. Recommendations include, for example...

  17. Proposal Improvements That Work

    Science.gov (United States)

    Dunn, F.

    1998-01-01

    Rocketdyne Propulsion and Power, an operating location of Boeing in Canoga Park, California is under contract with NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama for design, development, production, and mission support of Space Shuttle Main Engines (SSMEs). The contract was restructured in 1996 to emphasize a mission contracting environment under which Rocketdyne supports the Space Transportation System launch manifest of seven flights a year without the need for a detailed list of contract deliverables such as nozzles, turbopumps, and combustion devices. This contract structure is in line with the overall Space Shuttle program goals established by the NASA to fly safely, meet the flight manifest, and reduce cost. Rocketdyne's Contracts, Pricing, and Estimating team has worked for the past several years with representatives from MSFC, the local Defense Contract Management Command, and the DCAA to improve the quality of cost proposals to MSFC for contract changes on the SSME. The contract changes on the program result primarily from engineering change proposals for product enhancements to improve safety, maintainability, or operability in the space environment. This continuous improvement team effort has been successful in improving proposal quality, reducing cycle time, and reducing cost. Some of the principal lessons learned are highlighted here to show how proposal improvements can be implemented to enhance customer satisfaction and ensure cost proposals can be evaluated easily by external customers.

  18. Abuse Tolerance Improvements

    Energy Technology Data Exchange (ETDEWEB)

    Orendorff, Christopher J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nagasubramanian, Ganesan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Fenton, Kyle R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Allcorn, Eric [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    As lithium-ion battery technologies mature, the size and energy of these systems continues to increase (> 50 kWh for EVs); making safety and reliability of these high energy systems increasingly important. While most material advances for lithium-ion chemistries are directed toward improving cell performance (capacity, energy, cycle life, etc.), there are a variety of materials advancements that can be made to improve lithium-ion battery safety. Issues including energetic thermal runaway, electrolyte decomposition and flammability, anode SEI stability, and cell-level abuse tolerance continue to be critical safety concerns. This report highlights work with our collaborators to develop advanced materials to improve lithium-ion battery safety and abuse tolerance and to perform cell-level characterization of new materials.

  19. Improving Precision of Types

    DEFF Research Database (Denmark)

    Winther, Johnni

    Types in programming languages provide a powerful tool for the programmer to document the code so that a large aspect of the intent can not only be presented to fellow programmers but also be checked automatically by compilers. The precision with which types model the behavior of programs...... is crucial to the quality of these automated checks, and in this thesis we present three different improvements to the precision of types in three different aspects of the Java programming language. First we show how to extend the type system in Java with a new type which enables the detection of unintended...... mixing of unrelated types. Secondly, we present an improvement of the type checking algorithm in Java which enables the compiler to detect and ease the use of a common programming idiom called guarded casts. Thirdly, we present an improvement of the precision with which classes generated by a parser...

  20. The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits

    DEFF Research Database (Denmark)

    Jensen, Pia Rosgaard; Andersen, Thomas Levin; Pennypacker, Brenda L;

    2014-01-01

    in the interface between osteoclasts and surrounding osteoblast-lineage cells. This increase is expected to favor the osteoclast-osteoblast interactions required for bone formation. Regarding bone resorption itself, we show that ODN, but not ALN, treatment results in shallower resorption lacunae, a geometry...... the very last step of the resorption process. We hypothesize that ODN may therefore modify the remodeling events immediately following osteoclastic resorption. These events belong to the reversal phase and include recruitment of osteoblasts, which is critical for connecting bone resorption to formation. We...

  1. Synthesis of composite magnetic nanoparticles Fe3O4 with alendronate for osteoporosis treatment

    Science.gov (United States)

    Lee, Ming-Song; Su, Chao-Ming; Yeh, Jih-Chao; Wu, Pei-Ru; Tsai, Tien-Yao; Lou, Shyh-Liang

    2016-01-01

    Osteoporosis is a result of imbalance between bone formation by osteoblasts and resorption by osteoclasts (OCs). In the present study, we investigated the potential of limiting the aggravation of osteoporosis by reducing the activity of OCs through thermolysis. The proposed method is to synthesize bisphosphonate (Bis)-conjugated iron (II, III) oxide (Fe3O4) nanoparticles and incorporate them into OCs. The cells should be subsequently exposed to radiofrequency (RF) to induce thermolysis. In this study, particles of Fe3O4 were first synthesized by chemical co-precipitation and then coated with dextran (Dex). The Dex/Fe3O4 particles were then conjugated with Bis to form Bis/Dex/Fe3O4. Transmission electron microscopy revealed that the average diameter of the Bis/Dex/Fe3O4 particles was ~20 nm. All three kinds of nanoparticles were found to have cubic inverse spinel structure of Fe3O4 by the X-ray diffraction analysis. Fourier transform infrared spectroscopy confirmed that the Dex/Fe3O4 and Bis/Dex/Fe3O4 nanoparticles possessed their respective Dex and Bis functional groups, while a superconducting quantum interference device magnetometer measured the magnetic moment to be 24.5 emu. In addition, the Bis/Dex/Fe3O4 nanoparticles were fully dispersed in double-distilled water. Osteoblasts and OCs were individually cultured with the nanoparticles, and an MTT assay revealed that they were non-cytotoxic. An RF system (42 kHz and 450 A) was used to raise the temperature of the nanoparticles for 20 minutes, and the thermal effect was found to be sufficient to destroy OCs. Furthermore, in vivo studies verified that nanoparticles were indeed magnetic resonance imaging contrast agents and that they accumulated after being injected into the body of rats. In conclusion, we developed a water-dispersible magnetic nanoparticle that had RF-induced thermogenic properties, and the results indicated that the Bis/Dex/Fe3O4 nanoparticle had the potential for controlling osteoporosis.

  2. Hydroxyapatite, polycaprolactone and alendronate composites for bone regeneration in rabbits' olecranon: histological features

    Directory of Open Access Journals (Sweden)

    F.L. Valente

    2016-04-01

    Full Text Available O presente trabalho teve como objetivo avaliar a biocompatibilidade e a osseointegração de compósitos de hidroxiapatita (HA, policaprolactona (PCL e alendronato (ALN em defeitos ósseos produzidos no olécrano de coelhos. Trinta e seis coelhos foram distribuídos em quatro grupos, recebendo como tratamento: (1 compósito de HA (49,5%, PCL (49,5% e ALN (1%; (2 HA (50% e PCL (50%; (3 PCL (100%; e (4 solução salina 0,9%. As amostras para análise histológica foram coletadas de três animais de cada grupo aos oito, 45 e 90 dias de pós-operatório. No oitavo dia, as bordas do defeito ainda eram identificáveis em todos os grupos. Tecido ósseo novo era formado em contato com o biomaterial apenas nas formulações que incluíam HA. Essas características continuaram evidentes nos outros momentos analisados, embora o defeito estivesse preenchido pelo tecido regenerado. A presença dos biomateriais foi verificada nos três momentos em todos os grupos. Não houve evidências de reação indesejável ao biomaterial. As análises histológicas e histomorfométricas mostraram que os biomateriais são biocompatíveis e aqueles contendo a hidroxiapatita favoreceram a formação óssea no início do processo de regeneração, embora o alendronato não tenha apresentado qualquer efeito.

  3. Changes in bone density and turnover after alendronate or estrogen withdrawal

    DEFF Research Database (Denmark)

    Wasnich, Richard D; Bagger, Yu Z; Hosking, David J;

    2004-01-01

    groups described in the current report represent 860 women at baseline; 481 women entered year 5, and 430 completed 6 years. BMD steadily decreased in the placebo group during all 6 years. In contrast, spine and hip BMD increased during the first 4 years in the groups receiving daily continuous...

  4. Improve your communication skills

    CERN Document Server

    Barker, Alan

    2016-01-01

    Excellent communication skills are vital in today's workplace. Whether keeping the interest of a large audience, impressing a potential employer or simply winning the argument at an important meeting, sounding the part is key. This fourth edition of Improve Your Communication Skills is full of practical advice on all aspects of verbal and non-verbal communication. It gives vital tips on improving conversations and building rapport with colleagues, learning the skills of persuasion, and writing effective emails, letters and reports. This editionincludes new information focusing on communicating across borders and virtual teams and a new chapter on managing difficult conversations."

  5. Improving Alaryngeal Speech Intelligibility.

    Science.gov (United States)

    Christensen, John M.; Dwyer, Patricia E.

    1990-01-01

    Laryngectomized patients using esophageal speech or an electronic artificial larynx have difficulty producing correct voicing contrasts between homorganic consonants. This paper describes a therapy technique that emphasizes "pushing harder" on voiceless consonants to improve alaryngeal speech intelligibility and proposes focusing on the production…

  6. Driving collaborative improvement processes

    NARCIS (Netherlands)

    Middel, R.; Gieskes, J.; Fisscher, O.

    2005-01-01

    Continuous improvement is a consolidated concept in theory and practice, mainly in the context of stand-alone companies. However, the battlefield of competition is increasingly moving from the level of individual firms to that of organizational settings based on loose company boundaries and collabor

  7. Driving collaborative improvement processes

    NARCIS (Netherlands)

    Middel, Rick; Gieskes, José; Fisscher, Olaf

    2002-01-01

    Continuous Improvement is a consolidated concept in theory and practice, mainly in the context of stand-alone companies. However, the battlefield of competition is increasingly moving from the level of individual firms to that of organisational settings based on loose company boundaries and collabor

  8. Improving Software Developer's Competence

    DEFF Research Database (Denmark)

    Abrahamsson, Pekka; Kautz, Karlheinz; Sieppi, Heikki;

    2002-01-01

    Emerging agile software development methods are people oriented development approaches to be used by the software industry. The personal software process (PSP) is an accepted method for improving the capabilities of a single software engineer. Five original hypotheses regarding the impact of the ...

  9. Improvements in agricultural sciences

    Science.gov (United States)

    This editorial provides insight on investigations regarding advancements in agri-food quality and testing of eco-friendly organic farming methodologies. The discussion elaborates on the advantages of recent farming techniques and their impact on improved crop yield, crop quality, and minimization of...

  10. MCNP Progress & Performance Improvements

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Forrest B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bull, Jeffrey S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rising, Michael Evan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-04-14

    Twenty-eight slides give information about the work of the US DOE/NNSA Nuclear Criticality Safety Program on MCNP6 under the following headings: MCNP6.1.1 Release, with ENDF/B-VII.1; Verification/Validation; User Support & Training; Performance Improvements; and Work in Progress. Whisper methodology will be incorporated into the code, and run speed should be increased.

  11. Improving Student Behavior.

    Science.gov (United States)

    Hammond, James R.; Boivin, Real G.

    1991-01-01

    This document provides brief descriptions of 12 prevention strategies, 6 curriculum-based strategies, and 7 motivational strategies for improving student behavior. Alternative schools and programs, counseling, parent involvement, community involvement, student orientation programs, learning styles, writing activities, student codes of conduct,…

  12. Improving machinery reliability

    CERN Document Server

    Bloch, Heinz P

    1998-01-01

    This totally revised, updated and expanded edition provides proven techniques and procedures that extend machinery life, reduce maintenance costs, and achieve optimum machinery reliability. This essential text clearly describes the reliability improvement and failure avoidance steps practiced by best-of-class process plants in the U.S. and Europe.

  13. Nuclear energy efficiency improvements

    Energy Technology Data Exchange (ETDEWEB)

    Lauritzen, B.; Nonboel, E. [Technical Univ. of Denmark. DTU Nutech, Roskilde (Denmark); Kyrki-Rajamaeki, R. [Lappeenranta Univ. of Technology (Finland)

    2012-11-15

    Nuclear energy already today plays an important role in decarbonisation of the electricity sector while providing energy security and being economically competitive. Nuclear energy is characterized by its very high energy density and is well suited for large-scale, baseload electricity supply. Similar to renewable energy sources such as wind, solar or biomass, nuclear power is characterized by an abundant supply of its primary energy source, uranium, but is not limited to the same extent as these renewable energy sources from being an intermittent energy supply or imposing severe restrictions on land-use. Improving energy efficiency of nuclear power plants has contributed to a better utilization of the uranium resources and has helped improving the economic performance of nuclear power plants. This is to a large degree accomplished through optimisation of nuclear fuel assemblies as well as renewing turbines and generators. More importantly however, the overall economy of nuclear power has improved though better plant management leading to higher capacity factors and by extending the lifetimes of existing nuclear power plants. Provided that improved safety, economics and successful waste management can be demonstrated nuclear power is likely to grow in the future. Non-electricity applications may further boost the growth of nuclear energy, especially with the development of new reactor systems allowing for cogeneration of electricity and hydrogen or biofuels for transport. (Author)

  14. Sulfur recovery further improved

    Energy Technology Data Exchange (ETDEWEB)

    Borsboom, J.; Grinsven, M. van; Warners, A. van [Jacobs Nederland B.V., (Netherlands); Nisselrooy, P. van [Gastec N.V., (Netherlands)

    2002-04-01

    The original 100-year-old Claus process for producing sulfur from hydrogen sulfide in acid gas is described together with improvements which have been made over the years. The most recent modification, EUROCLAUS, achieves sulfur recoveries of 99-99.9 per cent. Five commercial units are being designed.

  15. Measuring to improve.

    Science.gov (United States)

    Klein, R; Bobbitt, M

    1995-01-01

    Rush Prudential Health Plans, a managed care company located in Chicago, Illinois, is implementing a service quality improvement process across the three products it markets in the Chicago area: The Anchor Plan (a primarily staff model HMO), The Affiliates Plan (a network model HMO), and The Plus Plan (a point of service plan). In 1994, the company instituted an annual member satisfaction research study, conducted across the three plans, and began building a link between external customer requirements and internal operations. The research process consisted of three stages: determining external customer requirements, translating these customer-defined "symptoms" into underlying root causes, and developing a service quality improvement action plan. Rush Prudential determined that traditional "report card" surveys would not meet their goals for the information measurement process. A detailed diagnostic telephone survey was used to provide a picture of the entire clinical encounter, from scheduling an appointment through the time a member left the physician's office. PMID:10151598

  16. IMPROVING CONCEPTUAL DESIGN QUALITY

    DEFF Research Database (Denmark)

    Bush, Stuart; Robotham, Antony John

    1999-01-01

    This paper will consider how Quality Function Deployment (QFD) and Design for Manufacture and Assembly (DFMA) processes can be used to improve the design quality of products at the concept stage. We appreciate that both QFD and DFMA are techniques that have been used for some time by mature product...... quality is maintained in design project work. The projects described have been carried out with products manufactured by small to medium sized enterprises (SME's), where we have found significant opportunities for product improvement. The quantitative nature of DFMA analysis results allows the novice...... developers, and the successes achieved using each have been widely reported. Here, though, we will share our experiences of using these tools with novice designers, i.e. student engineers.The use of both QFD and DFMA has proven to be a valuable approach for ensuring that a balanced consideration of design...

  17. Process Improvement: Customer Service.

    Science.gov (United States)

    Cull, Donald

    2015-01-01

    Utilizing the comment section of patient satisfaction surveys, Clark Memorial Hospital in Jeffersonville, IN went through a thoughtful process to arrive at an experience that patients said they wanted. Two Lean Six Sigma tools were used--the Voice of the Customer (VoC) and the Affinity Diagram. Even when using these tools, a facility will not be able to accomplish everything the patient may want. Guidelines were set and rules were established for the Process Improvement Team in order to lessen frustration, increase focus, and ultimately be successful. The project's success is driven by the team members carrying its message back to their areas. It's about ensuring that everyone is striving to improve the patients' experience by listening to what they say is being done right and what they say can be done better. And then acting on it.

  18. Measuring to improve.

    Science.gov (United States)

    Klein, R; Bobbitt, M

    1995-01-01

    Rush Prudential Health Plans, a managed care company located in Chicago, Illinois, is implementing a service quality improvement process across the three products it markets in the Chicago area: The Anchor Plan (a primarily staff model HMO), The Affiliates Plan (a network model HMO), and The Plus Plan (a point of service plan). In 1994, the company instituted an annual member satisfaction research study, conducted across the three plans, and began building a link between external customer requirements and internal operations. The research process consisted of three stages: determining external customer requirements, translating these customer-defined "symptoms" into underlying root causes, and developing a service quality improvement action plan. Rush Prudential determined that traditional "report card" surveys would not meet their goals for the information measurement process. A detailed diagnostic telephone survey was used to provide a picture of the entire clinical encounter, from scheduling an appointment through the time a member left the physician's office.

  19. Strategies for Improving Justification

    International Nuclear Information System (INIS)

    Good practice in radiology relies on a core principle that each examination is justified for the patient involved. An international workshop organized by the IAEA and the European Commission concluded that: “There is a significant and systemic practice of inappropriate examination in radiology.” Audit reveals that 20–50% of examinations are routinely not justified and the figure can be as high as 60–77% in particular cases (e.g. for lumbar spine examinations or cardiac angiography). Doctors/health professionals generally have poor awareness of the risks involved and consistently underestimate them. Knowledge of, and compliance with, guidelines for referral for common examinations is poor. The ethical background considerations to this situation are briefly reviewed and a strategy for improvement is proposed, i.e. the global ‘three As’ campaign of improving awareness, appropriateness and audit adopted by the IAEA. (author)

  20. Diversification improves interpolation

    CERN Document Server

    Giesbrecht, Mark

    2011-01-01

    We consider the problem of interpolating an unknown multivariate polynomial with coefficients taken from a finite field or as numerical approximations of complex numbers. Building on the recent work of Garg and Schost, we improve on the best-known algorithm for interpolation over large finite fields by presenting a Las Vegas randomized algorithm that uses fewer black box evaluations. Using related techniques, we also address numerical interpolation of sparse complex polynomials, and provide the first provably stable algorithm (in the sense of relative error) for this problem, at the cost of modestly more interpolation points. A key new technique is a randomization which makes all coefficients of the unknown polynomial distinguishable, producing what we call a diverse polynomial. Another departure of our algorithms from most previous approaches is that they do not rely on root finding as a subroutine. We show how these improvements affect the practical performance with trial implementations.

  1. Improving surgical outcomes

    Directory of Open Access Journals (Sweden)

    Tony Walia

    2008-12-01

    Full Text Available Outcomes of cataract surgery are worse than we would like them to be. Community-based studies show that up to 40% of eyes have a postoperative presenting vision of < 6/60. Eyes with intraocular lenses (IOLs do better; however, it has been shown that even in prosperous middle-income countries, such as Venezuela, in 20% of pseudophakic eyes presenting vision was < 6/60 and in 15% best corrected vision was worse than 6/60.Poor outcomes matter. Patients deserve improved vision whenever possible and poor outcomes deter prospective patients from coming for surgery and probably reduce their willingness to pay for their treatment – particularly if they have to pay in advance!In this article, we offer some suggestions for improving the quality of cataract surgery. We admit that there is little evidence base for most of these suggestions and that some of them are controversial. However, we hope to stimulate debate.

  2. Process Improvement: Customer Service.

    Science.gov (United States)

    Cull, Donald

    2015-01-01

    Utilizing the comment section of patient satisfaction surveys, Clark Memorial Hospital in Jeffersonville, IN went through a thoughtful process to arrive at an experience that patients said they wanted. Two Lean Six Sigma tools were used--the Voice of the Customer (VoC) and the Affinity Diagram. Even when using these tools, a facility will not be able to accomplish everything the patient may want. Guidelines were set and rules were established for the Process Improvement Team in order to lessen frustration, increase focus, and ultimately be successful. The project's success is driven by the team members carrying its message back to their areas. It's about ensuring that everyone is striving to improve the patients' experience by listening to what they say is being done right and what they say can be done better. And then acting on it. PMID:26571974

  3. Improving Gabor Noise

    OpenAIRE

    Lagae, Ares; Lefebvre, Sylvain; Dutré, Philip

    2011-01-01

    We have recently proposed a new procedural noise function, Gabor noise, which offers a combination of properties not found in existing noise functions. In this paper, we present three significant improvements to Gabor noise: (1) an isotropic kernel for Gabor noise, which speeds up isotropic Gabor noise with a factor of roughly two, (2) an error analysis of Gabor noise, which relates the kernel truncation radius to the relative error of the noise, and (3) spatially varying Gabor noise, which e...

  4. Twitter Improves Influenza Forecasting

    OpenAIRE

    Paul, Michael J.; Dredze, Mark; Broniatowski, David

    2014-01-01

    Accurate disease forecasts are imperative when preparing for influenza epidemic outbreaks; nevertheless, these forecasts are often limited by the time required to collect new, accurate data. In this paper, we show that data from the microblogging community Twitter significantly improves influenza forecasting. Most prior influenza forecast models are tested against historical influenza-like illness (ILI) data from the U.S. Centers for Disease Control and Prevention (CDC). These data are releas...

  5. Educational Service Improvement Cycle

    OpenAIRE

    Rothe, Hannes

    2016-01-01

    Terms like e-, m- or Blended Learning show, currently many educational services are supported by web technologies. Within such services predominant parts of learner’s usage processes are hidden from the educator’s perception. In front of a service-dominant logic understanding usage processes is essential to comprehend the value-co-creation of educators and learners. Learning analytics may hold methods to enable a continual improvement process by collecting and analyzing usage data. A systemat...

  6. Improve your reading

    CERN Document Server

    Fry, Ron

    2012-01-01

    Help your students discover the practical solution to their reading frustrations, with Improve Your Reading. Written by bestselling author and education advocate Ron Fry, this book avoids gimmicks and tricks in favor of proven strategies that will help your students better retain and comprehend what they've read in any textbook, in any course, at any academic level. Endlessly adaptable to each student's individual learning needs, the text focuses on fundamental skills students can carry beyond the classroom.

  7. Improving operating room safety

    OpenAIRE

    Garrett Jill; Hurlbert Scott N

    2009-01-01

    Abstract Despite the introduction of the Universal Protocol, patient safety in surgery remains a daily challenge in the operating room. This present study describes one community health system's efforts to improve operating room safety through human factors training and ultimately the development of a surgical checklist. Using a combination of formal training, local studies documenting operating room safety issues and peer to peer mentoring we were able to substantially change the culture of ...

  8. Improving customer satisfaction

    OpenAIRE

    Wei, Yu

    2011-01-01

    Today, the competition among enterprises is growing in intensity and organizations of all types and sizes have increasingly come to understand the importance of customer satisfaction and good services. The purpose of this study is to investigate the present level of customer satisfaction with language training institutes and find out any possible areas of improvement. This thesis will discuss and analyze the factors that influence the customer’s level of satisfaction and assist the case compa...

  9. Improving Carbon Fixation Pathways

    OpenAIRE

    Ducat, Daniel C.; Silver, Pamela A

    2012-01-01

    A recent resurgence in basic and applied research on photosynthesis has been driven in part by recognition that fulfilling future food and energy requirements will necessitate improvements in crop carbon-fixation efficiencies. Photosynthesis in traditional terrestrial crops is being reexamined in light of molecular strategies employed by photosynthetic microbes to enhance the activity of the Calvin cycle. Synthetic biology is well-situated to provide original approaches for compartmentalizing...

  10. Improved Adaptive Fingerprint Binarization

    OpenAIRE

    Bartunek, Josef Ström; Nilsson, Mikael; Nordberg, Jörgen; Claesson, Ingvar

    2008-01-01

    In this paper improvements to a previous work are presented. Removing the redundant artifacts in the fingerprint mask is introduced enhancing the final result. The proposed method is entirely adaptive process adjusting to each fingerprint without any further supervision of the user. Hence, the algorithm is insensitive to the characteristics of the fingerprint sensor and the various physical appearances of the fingerprints. Further, a detailed description of fingerprint mask generation not ful...

  11. MEMORY IMPROVING FOODS

    Directory of Open Access Journals (Sweden)

    Akula Annapurna

    2013-09-01

    Full Text Available Learning is a lifelong process of transforming information and experience into knowledge, skills, behaviorand attitudes. Memory is the ability of the brain to store, retain and subsequently to recall information received fromthe world. Cognition can be defined as organization of information. It includes acquiring information (perception,selecting (attention, representing (understanding and retaining (memory information and using it to guidebehavior (reasoning and coordination of motor outputs.There are so many conditions associated with memory and cognitive impairment which include Aging,Alzheimer’s disease, Stroke, Stress, Head injuries, Seizures, Benzodiazepines, Brain tumors, Depression, Temporallobe defects and Schizophrenia etc.Choline rich foods can enhance memory and learning and may be useful in improving cognitive abilities. Theseinclude sea foods, liver, egg yolk, soysbeans, broccoli, ash gourd. Coloured fruits and vegetables are good source ofantioxidants which improve concentration. It is advised to decrease the consumption of foods rich in transfats likehydrogenated oils, fried foods, beef, pork, mutton and ice creams and pastries. Such foods increase the deposition offats in the neurons and impair cognition. Tea, cocoa and turmeric are reported to have good nootropic activity i.e.improving memory and learning. Apart from the foods, one should keep the brain active to maintain its cognitivefunction well.

  12. Improved flywheel materials :

    Energy Technology Data Exchange (ETDEWEB)

    Boyle, Timothy J.; Bell, Nelson S; Ehlen, Mark Andrew; Anderson, Benjamin John; Miller, William Kenneth

    2013-09-01

    As alternative energy generating devices (i.e., solar, wind, etc) are added onto the electrical energy grid (AC grid), irregularities in the available electricity due to natural occurrences (i.e., clouds reducing solar input or wind burst increasing wind powered turbines) will be dramatically increased. Due to their almost instantaneous response, modern flywheel-based energy storage devices can act a mechanical mechanism to regulate the AC grid; however, improved spin speeds will be required to meet the necessary energy levels to balance these green energy variances. Focusing on composite flywheels, we have investigated methods for improving the spin speeds based on materials needs. The so-called composite flywheels are composed of carbon fiber (C-fiber), glass fiber, and a glue (resin) to hold them together. For this effort, we have focused on the addition of fillers to the resin in order to improve its properties. Based on the high loads required for standard meso-sized fillers, this project investigated the utility of ceramic nanofillers since they can be added at very low load levels due to their high surface area. The impact that TiO2 nanowires had on the final strength of the flywheel material was determined by a three-point-bend test. The results of the introduction of nanomaterials demonstrated an increase in strength of the flywheels C-fiber-resin moiety, with an upper limit of a 30% increase being reported. An analysis of the economic impact concerning the utilization of the nanowires was undertaken and after accounting for new-technology and additional production costs, return on improved-nanocomposite investment was approximated at 4-6% per year over the 20-year expected service life. Further, it was determined based on the 30% improvement in strength, this change may enable a 20-30% reduction in flywheel energy storage cost ($/kW-h).

  13. Improvement of plastic properties

    Directory of Open Access Journals (Sweden)

    D. Manas

    2008-08-01

    Full Text Available Purpose: of this paper is to present the results of research programme on improve polymer materials properties by irradiation. This method can be helpful in improving some of mechanical properties and thermal stability of polymers.Design/methodology/approach: Radiation processing involves the use of natural or man-made sources of high energy radiation on an industrial scale. The principle of the radiation processing is the ability of the high energy radiation to produce reactive cations, anions, and free radicals in materials. The industrial application of the radiation processing of plastic and composites includes polymerization, cross-linking and grafting. Radiation processing involves mainly the use of either electron beams from electron accelerators or gamma radiation from Cobalt-60 sources. The big advantage of radiation processing is, that does not make the product radioactive. In this research programme, the properties of natural (not irradiated and irradiated polypropylene (PP, both unfilled and filled with 25% of glass fibres, were compared. Flexural strength, tensile strength, impact strength, thermal stability and complex modulus E* were researched. The injection moulding machine DEMAG – EGROTECH 50 – 200 was used for sample preparation. Irradiation was carried out in the company BGS Beta Gamma Service GmbH Co, KG, Saal am Donau, Germany with the electron rays, electron energy 10 MeV, doses of 15 and 33 kGy.Findings: The most important results are the enormous improvement of the thermal stability and some mechanical properties of irradiated PP.Practical implications: From the practical point of view the most important is the enormous improvement of the thermal stability of irradiated PP. The majority of industrial applications of radiation processing are cross-linking of wire and cable insulations, tube, heat shrink cables, components of tires, composites, moulded products for automotive and electrical industry etc

  14. Improved Capacitive Liquid Sensor

    Science.gov (United States)

    Waldman, Francis A.

    1992-01-01

    Improved capacitive sensor used to detect presence and/or measure thickness of layer of liquid. Electrical impedance or admittance of sensor measured at prescribed frequency, and thickness of liquid inferred from predetermined theoretical or experimental relationship between impedance and thickness. Sensor is basically a three-terminal device. Features interdigitated driving and sensing electrodes and peripheral coplanar ground electrode that reduces parasitic effects. Patent-pending because first to utilize ground plane as "shunting" electrode. System less expensive than infrared, microwave, or refractive-index systems. Sensor successfully evaluated in commercial production plants to characterize emulsions, slurries, and solutions.

  15. Retaining caregivers, improving care.

    Science.gov (United States)

    Bodwell, Wendy; Dent, Sara; Grant, Tracie; Hammerly, Milt; Mamula, Jeanie

    2006-01-01

    Text Summary In 2004, Centura Health's long-term care centers took part in a pilot project, sponsored by the Centers for Medicare & Medicaid Services, called "Improving Nursing Home Culture through Workforce Retention." A 30-member team comprising Centura leaders and long-term facility staff looked at Centura's eight participating facilities through residents' and employees' eyes. The goal of the team's reflection and subsequent changes was to create a culture in which decisions are focused on resident care and organizational policies are based on respect for employees. At the end of the first year, residents seemed happier and employee satisfaction and involvement increased at all eight Centura facilities. PMID:16519278

  16. Improvements in radiography

    International Nuclear Information System (INIS)

    A Video viewing system in combination with a continuously pulsing X-ray fluoroscopy system is described. Improvement of video picture quality is claimed. The patent describes a source of X-ray trigger pulses at a given frequency generating pulses at this frequency, a fluorescent screen for image formation, a video signal utilization device, a video viewing system and other equipment relating. Video viewing systems allow qualitative assessments of events within gas turbine engines to be made, particularly the sequence of engine seal movement. (U.K.)

  17. Improving aircraft energy efficiency

    Science.gov (United States)

    Povinelli, F. P.; Klineberg, J. M.; Kramer, J. J.

    1976-01-01

    Investigations conducted by a NASA task force concerning the development of aeronautical fuel-conservation technology are considered. The task force estimated the fuel savings potential, prospects for implementation in the civil air-transport fleet, and the impact of the technology on air-transport fuel use. Propulsion advances are related to existing engines in the fleet, to new production of current engine types, and to new engine designs. Studies aimed at the evolutionary improvement of aerodynamic design and a laminar flow control program are discussed and possibilities concerning the use of composite structural materials are examined.

  18. Continuous Improvement and Collaborative Improvement: Similarities and Differences

    DEFF Research Database (Denmark)

    Middel, Rick; Boer, Harry; Fisscher, Olaf

    2006-01-01

    A substantial body of theoretical and practical knowledge has been developed on continuous improvement. However, there is still a considerable lack of impirically grounded contributions and theories on collaborative improvement, that is, continuous improvement in an interorganizational setting...... between continuous and collaborative improvement. The main differences relate to the role of hierarchy/market, trust, power and commitment to collaboration, all of which are related to differences between the settings in which continuous and collaborative improvement unfold....

  19. Improved Biosensors for Soils

    Science.gov (United States)

    Silberg, J. J.; Masiello, C. A.; Cheng, H. Y.

    2014-12-01

    Microbes drive processes in the Earth system far exceeding their physical scale, affecting crop yields, water quality, the mobilization of toxic materials, and fundamental aspects of soil biogeochemistry. The tools of synthetic biology have the potential to significantly improve our understanding of microbial Earth system processes: for example, synthetic microbes can be be programmed to report on environmental conditions that stimulate greenhouse gas production, metal oxidation, biofilm formation, pollutant degradation, and microbe-plant symbioses. However, these tools are only rarely deployed in the lab. This research gap arises because synthetically programmed microbes typically report on their environment by producing molecules that are detected optically (e.g., fluorescent proteins). Fluorescent reporters are ideal for petri-dish applications and have fundamentally changed how we study human health, but their usefulness is quite limited in soils where detecting fluorescence is challenging. Here we describe the construction of gas-reporting biosensors, which release nonpolar gases that can be detected in the headspace of incubation experiments. These constructs can be used to probe microbial processes within soils in real-time noninvasive lab experiments. These biosensors can be combined with traditional omics-based approaches to reveal processes controlling soil microbial behavior and lead to improved environmental management decisions.

  20. Improving tumour response

    International Nuclear Information System (INIS)

    Radiation oncology is in the middle of the most exciting developments in its 100-year history. Progress in treatment planning and delivery, in medical imaging and in basic cancer and normal tissue biology is likely to change the indication for radiotherapy as well as the way it is prescribed and delivered. Technological and conceptual advances, in particular the development of the multi-leaf collimator and the concept of inverse treatment planning, have led to the introduction of intensity modulated radiation therapy (IMRT) with its capability to plan and deliver non-uniform dose distributions in the clinic. This has forced us to re-think radiation oncology: refining the indication for radiotherapy, optimizing the prescription of dose distributions and considering how, based on clinical evidence, radiation can best be combined with other treatment modalities, surgery, cytotoxic chemotherapy and biologically targeted therapies. The attraction of radiation therapy as an element of multi-modality cancer therapy is that it induces DNA damage that can be modulated in space and time. Progress in basic cancer biology, genomics and proteomics, as well as biological imaging provides novel avenues for individualization of cancer therapy and for biological optimization of radiotherapy. In improving cancer care, it is the therapeutic ratio, rather than tumour control per se, that must be optimised. Interestingly, the two main avenues for improving the effectiveness of radiotherapy currently being actively pursued in the clinic generally aim at different sides of the therapeutic ratio: 3D conformal radiotherapy and IMRT predominantly aim to reduce normal-tissue side effects - and by doing this, open the way for dose escalation that may lead to increased tumour control rates - whereas combined radio-chemotherapy aims to improve tumour response - while keeping the fingers crossed that this will not increase normal-tissue complications to the same extent. In parallel with these

  1. Improvement sedimentometer Wigner

    Directory of Open Access Journals (Sweden)

    V. O. Tertyshnyi

    2013-09-01

    Full Text Available Introduction. These units are classical Wigner sedimentogenesis meters, its advantages and disadvantages. Materials and performance. A device capacitance stnogo-meter level difference between the suspension, located in a wide ditch and dispersed medium in the capillary tube sedimentometer Wigner to automate the process of reading the height of the column, in accordance with the time of the precipitation fraction solids slurry in a wide receiver with the possibility of further automatic processing of particle deposition curve colloidal system. Resume. A device for improving sedimentometer Wigner, which automates the process of the computation of the moments of the deposition time of the individual fractions of the solid phase with concomitant fixation difference between the liquid levels in both knees sedimentometer, which allows to determine with mathematical processing the mass fractions of each fraction in the sediment.

  2. Room for improvement

    DEFF Research Database (Denmark)

    Storvang, Pia; Dalby, Mette Strømgaard

    2015-01-01

    from a project with four Danish medium-sized manufacturing companies aiming to become more competitive in the European export market. In the project, one challenge was how to convey results from customer interviews and user studies from the researcher team (which in all instances included a company...... manager) to the development team in each company. We chose to collaboratively build a ‘war room’ in each of the companies to make sense of research materials and establish design principles for products that would better align with customer needs.......This paper develops the notion of a project war room as an innovation practice in companies. We argue that the consistent use of a project war room, in which customer and user research serves as a background for design work, improve the quality of product innovation. We describe our experiences...

  3. Mutations in lettuce improvement.

    Science.gov (United States)

    Mou, Beiquan

    2011-01-01

    Lettuce is a major vegetable in western countries. Mutations generated genetic variations and played an important role in the domestication of the crop. Many traits derived from natural and induced mutations, such as dwarfing, early flowering, male sterility, and chlorophyll deficiency, are useful in physiological and genetic studies. Mutants were also used to develop new lettuce products including miniature and herbicide-tolerant cultivars. Mutant analysis was critical in lettuce genomic studies including identification and cloning of disease-resistance genes. Mutagenesis combined with genomic technology may provide powerful tools for the discovery of novel gene alleles. In addition to radiation and chemical mutagens, unconventional approaches such as tissue or protoplast culture, transposable elements, and space flights have been utilized to generate mutants in lettuce. Since mutation breeding is considered nontransgenic, it is more acceptable to consumers and will be explored more in the future for lettuce improvement. PMID:22287955

  4. Improving University Research Value

    Directory of Open Access Journals (Sweden)

    Kelley O’Reilly

    2012-07-01

    Full Text Available This article investigates the current data management practices of university researchers at an Intermountain West land-grant research university in the United States. Key findings suggest that researchers are primarily focused on the collection and housing of research data. However, additional research value exists within the other life cycle stages for research data—specifically in the stages of delivery and maintenance. These stages are where most new demands and requirements exist for data management plans and policies that are conditional for external grant funding; therefore, these findings expose a “gap” in current research practice. These findings should be of interest to academics and practitioners alike as findings highlight key management gaps in the life cycle of research data. This study also suggests a course of action for academic institutions to coalesce campus-wide assets to assist researchers in improving research value.

  5. Deceleration Orbit Improvements

    Energy Technology Data Exchange (ETDEWEB)

    Church, M.

    1991-04-26

    During the accelerator studies period of 12/90-1/91 much study time was dedicated to improving the E760 deceleration ramps. 4 general goals were in mind: (1) Reduce the relative orbit deviations from the nominal reference orbit as much as possible. This reduces the potential error in the orbit length calculation - which is the primary source of error in the beam energy calculation. (2) Maximize the transverse apertures. This minimizes beam loss during deceleration and during accidental beam blow-ups. (3) Measure and correct lattice parameters. Knowledge of {gamma}{sub T}, {eta}, Q{sub h}, Q{sub v}, and the dispersion in the straight sections allows for a more accurate energy calculation and reliable SYNCH calculations. (4) Minimize the coupling. This allows one to discern between horizontal and vertical tunes.

  6. Improved poultry house

    Energy Technology Data Exchange (ETDEWEB)

    None

    1983-01-01

    The relationship of energy and poultry production was explored in three areas: methane production from litter, broiler house insulation, and broiler house HVAC systems. The findings show that while a methane plant would not be popular with individual American poultry producers; the pay back in fuel and fertilizer, if the plant was located in close proximinity to the processing plant, would be favorable. Broiler house insulation has been dramatically improved since the outset of this study. Presently, all new installations in the survey area are the Environmental houses which are fully insulated. HVAC systems have had to keep pace with the introduction of better insulation. The new Environmental houses HVAC systems are fully automated and operating on a positive atmosphere principal. Ammonia and other problems have been kept in check while reducing air changes per house from a high of 7 per hour to as little as 3 per hour.

  7. Wind energy efficiency improvements

    Energy Technology Data Exchange (ETDEWEB)

    Hauge Madsen, P.; Badger, J.; Rasmussen, Flemming; Soerensen, Poul

    2012-11-15

    As we have shown above, wind energy can help to secure energy efficiency in power generation, and research results and tools are being developed that will increase the role of wind energy in the global energy supply. An important instrument is the development of wind turbine technology to reduce capital and operational costs. This has not been the emphasis in this chapter, though; instead we have focused on equally important instruments, namely making best use of the wind resource and available sites, adapting wind farm layout and technology to the increased exploitation of wind, and improving the interaction between wind farms and the power system. With these developments we expect that wind energy can become the backbone of the power system globally and play a major role in creating an efficient and sustainable power system. (Author)

  8. Improving Power Converter Reliability

    DEFF Research Database (Denmark)

    Ghimire, Pramod; de Vega, Angel Ruiz; Beczkowski, Szymon;

    2014-01-01

    The real-time junction temperature monitoring of a high-power insulated-gate bipolar transistor (IGBT) module is important to increase the overall reliability of power converters for industrial applications. This article proposes a new method to measure the on-state collector?emitter voltage...... of a high-power IGBT module during converter operation, which may play a vital role in improving the reliability of the power converters. The measured voltage is used to estimate the module average junction temperature of the high and low-voltage side of a half-bridge IGBT separately in every fundamental...... cycle of the current by calibrating them at load current. The measurement is very accurate and also measures the voltage at the middle of a pulse-width modulation (PWM) switching. A major objective is that this method is designed to be implemented in real applications. The performance of this technique...

  9. Towards Improved Biomarker Research

    DEFF Research Database (Denmark)

    Kjeldahl, Karin

    is investigated and followed by some suggestions which can potentially improve the chances of a successful outcome of an omics study. A method widely applied in the analysis of omics studies is Partial Least Squares (PLS) regression which is one of the work horses within the chemometrics tool box; a method which...... is used both for regression and classification purposes. This method has proven its strong worth in the multivariate data analysis throughout an enormous range of applications; a very classic data type is near infrared (NIR) data, but many similar data types have also be very successful....... On that background, the general characteristics of omics data are described and related to the characteristics of classical NIR-type data. This shows that omics data, which are generally much bigger data sets than classical data, are not just simple extensions of NIR data. The sample type, analytical method...

  10. Software Engineering Improvement Plan

    Science.gov (United States)

    2006-01-01

    In performance of this task order, bd Systems personnel provided support to the Flight Software Branch and the Software Working Group through multiple tasks related to software engineering improvement and to activities of the independent Technical Authority (iTA) Discipline Technical Warrant Holder (DTWH) for software engineering. To ensure that the products, comments, and recommendations complied with customer requirements and the statement of work, bd Systems personnel maintained close coordination with the customer. These personnel performed work in areas such as update of agency requirements and directives database, software effort estimation, software problem reports, a web-based process asset library, miscellaneous documentation review, software system requirements, issue tracking software survey, systems engineering NPR, and project-related reviews. This report contains a summary of the work performed and the accomplishments in each of these areas.

  11. Measuring improved patient choice.

    Science.gov (United States)

    Holmes-Rovner, M; Rovner, D R

    2000-08-01

    Patient decision support (PDS) tools or decision aids have been developed as adjuncts to the clinical encounter. Their aim is to support evidence-based patient choice. Clinical trials of PDS tools have used an array of outcome measures to determine efficacy, including knowledge, satisfaction, health status and consistency between patient choice and values. This paper proposes that the correlation between 'subjective expected utility' (SEU) and decision may be the best primary endpoint for trials. SEU is a measure usually used in behavioural decision theory. The paper first describes how decision support tools may use decision analysis to structure the presentation of evidence and guide patient decision-making. Uses of expected utility (EU) are suggested for evaluating PDS tools when improving population health status is the objective. SEU is the theoretically better measure when internal consistency of patient choices is the objective. PMID:11083037

  12. Improving efficiency in stereology

    DEFF Research Database (Denmark)

    Keller, Kresten Krarup; Andersen, Ina Trolle; Andersen, Johnnie Bremholm;

    2013-01-01

    of the study was to investigate the time efficiency of the proportionator and the autodisector on virtual slides compared with traditional methods in a practical application, namely the estimation of osteoclast numbers in paws from mice with experimental arthritis and control mice. Tissue slides were scanned......, a proportionator sampling and a systematic, uniform random sampling were simulated. We found that the proportionator was 50% to 90% more time efficient than systematic, uniform random sampling. The time efficiency of the autodisector on virtual slides was 60% to 100% better than the disector on tissue slides. We...... conclude that both the proportionator and the autodisector on virtual slides may improve efficiency of cell counting in stereology....

  13. Improving staff selection processes.

    Science.gov (United States)

    Cerinus, Marie; Shannon, Marina

    2014-11-11

    This article, the second in a series of articles on Leading Better Care, describes the actions undertaken in recent years in NHS Lanarkshire to improve selection processes for nursing, midwifery and allied health professional (NMAHP) posts. This is an area of significant interest to these professions, management colleagues and patients given the pivotal importance of NMAHPs to patient care and experience. In recent times the importance of selecting staff not only with the right qualifications but also with the right attributes has been highlighted to ensure patients are well cared for in a safe, effective and compassionate manner. The article focuses on NMAHP selection processes, tracking local, collaborative development work undertaken to date. It presents an overview of some of the work being implemented, highlights a range of important factors, outlines how evaluation is progressing and concludes by recommending further empirical research.

  14. Software Process Improvement

    DEFF Research Database (Denmark)

    Kuhrmann, Marco; Diebold, Philipp; Münch, Jürgen

    2016-01-01

    Software process improvement (SPI) is around for decades: frameworks are proposed, success factors are studied, and experiences have been reported. However, the sheer mass of concepts, approaches, and standards published over the years overwhelms practitioners as well as researchers. What is out...... there? Are there new trends and emerging approaches? What are open issues? Still, we struggle to answer these questions about the current state of SPI and related research. In this article, we present results from an updated systematic mapping study to shed light on the field of SPI, to develop a big...... theories and models on SPI in general. In particular, standard SPI models like CMMI and ISO/IEC 15504 are analyzed, enhanced, and evaluated for applicability in practice, but these standards are also critically discussed, e.g., from the perspective of SPI in small-to-medium-sized companies, which leads...

  15. Software Process Improvement

    DEFF Research Database (Denmark)

    Kuhrmann, Marco; Konopka, Claudia; Nellemann, Peter;

    2016-01-01

    Software process improvement (SPI) is around for decades: frameworks are proposed, success factors are studied, and experiences have been reported. However, the sheer mass of concepts, approaches, and standards published over the years overwhelms practitioners as well as researchers. What is out...... there? Are there new emerging approaches? What are open issues? Still, we struggle to answer the question for what is the current state of SPI and related research? We present initial results from a systematic mapping study to shed light on the field of SPI and to draw conclusions for future research...... directions. An analysis of 635 publications draws a big picture of SPI-related research of the past 25 years. Our study shows a high number of solution proposals, experience reports, and secondary studies, but only few theories. In particular, standard SPI models are analyzed and evaluated for applicability...

  16. PURSUING PRODUCTIVITY IMPROVEMENT

    Directory of Open Access Journals (Sweden)

    N.H.B. Faull

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: This paper examines the results of a concerted effort to move to a more rigorous and scientific basis for managing for improved productivity. The point of departure is a question, in the mouth of the chief executive officer of an organization: "How can we improve productivity?" The hypothesis is framed in terms of two contextual factors and six specific factors. The contextual factors are: create a questioning or learning culture, and develop a "cause-effect vision" to motivate questioning. The specific activities of the organization should be characterized by goals, feedback, participation, experimenation, pressure, and perseverance. The results of twelve audits of South African organizations, involving some 200 interviews and 2000 questionnaires, have been used to test the above hypothesis. The paper presents some of these results to indicate support for aspects of the hypothesis.

    AFRIKAANSE OPSOMMING: Hierdie artikel ondersoek die uitslae van 'n doelbewuste poging om 'n meer wetenskaplike grondslag to vind vir die bestuur van produktiwiteitsverbetering. Die uitgangspunt is 'n vraag, uit die mond van die top uitvoerende beampte van 'n organisasie: "Hoe kan ons produktiwiteit verbeter?" Die hipotese worde uiteengesit in terme van twee kontekstuele faktore en ses spesifieke faktore. Die kontekstuele faktore is: Skep 'n kultuur van bevraging of leer, en ontwikkel 'n "oorsaak-uitwerking visioen" om bevraging te motiveer. Die spesifieke aktiwiteite van die organisasie moet deur doelwitte, terugvoer, deelname, eksperimentasie, druk, en deursettings-vermoe gekenmerk word. Die uitslae van twaalf aUditerings in suid Afrikaanse organisasies, wat ongeveer 200 onderhoude en 2000 questionnaires behels het, was gebruik om die bestaande hipotese te toets. Hierdie artikel Ie voor van hierdie uitslae om ondersteuning vir aspekte van die hipotese te toon.

  17. Efficiency improvements in transport

    Energy Technology Data Exchange (ETDEWEB)

    Schramm, J. [Technical Univ. of Denmark. DTU Mechanical Engineering, Kgs. Lyngby (Denmark); Christensen, Linda; Jensen, Thomas C. [Technical Univ. of Denmark. DTU Transport, Kgs. Lyngby (Denmark)

    2012-11-15

    Transport of people, personal belongings and goods in private cars is fundamental to our modern welfare society and economic growth, and has grown steadily over many decades. Motor fuels have been based almost entirely on crude oil for the last century. During the last couple of decades engines built for traditional fuels have become more advanced and efficient; this has reduced fuel consumption by around 40% and emissions by more than 90%. Only in the same time span have we begun to look at alternatives to fossil fuels. Biofuels such as biodiesel, bioethanol, biomethanol and biogas can replace petrol and diesel, and in recent years algae have shown a new potential for diesel fuel. Natural gas is also becoming an interesting fuel due to its large resources worldwide. GTL, CTL and BTL are liquid fuels produced from solid or gaseous sources. GTL and CTL are expensive to produce and not very CO{sub 2}-friendly, but they are easily introduced and need little investment in infrastructure and vehicles. DME is an excellent fuel for diesel engines. Methanol and DME produced from biomass are among the most CO{sub 2}-reducing fuels and at the same time the most energy-efficient renewable fuels. Fuel cell vehicles (FCVs) are currently fuelled by hydrogen, but other fuels are also possible. There are, however, several barriers to the implementation of fuel cell vehicles. In particular, a hydrogen infrastructure needs to be developed. Electric vehicles (EVs) have the advantage that energy conversion is centralised at the power plant where it can be done at optimum efficiency and emissions. EVs have to be charged at home, and also away from home when travelling longer distances. With an acceptable fast charging infrastructure at least 85% of the one-car families in Denmark could be potential EV customers. Range improvements resulting from better batteries are expected to create a large increase in the number of EVs in Denmark between 2020 and 2030. The hybrid electric vehicle

  18. Regulatory Streamlining and Improvement

    Energy Technology Data Exchange (ETDEWEB)

    Mark A. Carl

    2006-07-11

    The Interstate Oil and Gas Compact Commission (IOGCC) engaged in numerous projects outlined under the scope of work discussed in the United States Department of Energy (DOE) grant number DE-FC26-04NT15456 awarded to the IOGCC. Numerous projects were completed that were extremely valuable to state oil and gas agencies as a result of work performed utilizing resources provided by the grant. There are numerous areas in which state agencies still need assistance. This additional assistance will need to be addressed under future scopes of work submitted annually to DOE's Project Officer for this grant. This report discusses the progress of the projects outlined under the grant scope of work for the 2005-2006 areas of interest, which are as follows: Area of Interest No. 1--Regulatory Streamlining and Improvement: This area of interest continues to support IOGCC's regulatory streamlining efforts that include the identification and elimination of unnecessary duplications of efforts between and among state and federal programs dealing with exploration and production on public lands. Area of Interest No. 2--Technology: This area of interest seeks to improve efficiency in states through the identification of technologies that can reduce costs. Area of Interest No. 3--Training and Education: This area of interest is vital to upgrading the skills of regulators and industry alike. Within the National Energy Policy, there are many appropriate training and education opportunities. Education was strongly endorsed by the President's National Energy Policy Development group. Acting through the governors offices, states are very effective conduits for the dissemination of energy education information. While the IOGCC favors the development of a comprehensive, long-term energy education plan, states are also supportive of immediate action on important concerns, such as energy prices, availability and conservation. Area of Interest No. 4--Resource Assessment and

  19. Improving operating room schedules.

    Science.gov (United States)

    Li, Fei; Gupta, Diwakar; Potthoff, Sandra

    2016-09-01

    Operating rooms (ORs) in US hospitals are costly to staff, generate about 70 % of a hospital's revenues, and operate at a staffed-capacity utilization of 60-70 %. Many hospitals allocate blocks of OR time to individual or groups of surgeons as guaranteed allocation, who book surgeries one at a time in their blocks. The booking procedure frequently results in unused time between surgeries. Realizing that this presents an opportunity to improve OR utilization, hospitals manually reschedule surgery start times one or two days before each day of surgical operations. The purpose of rescheduling is to decrease OR staffing costs, which are determined by the number of concurrently staffed ORs. We formulate the rescheduling problem as a variant of the bin-packing problem with interrelated items, which are the surgeries performed by the same surgeon. We develop a lower bound (LB) construction algorithm and prove that the LB is at least (2/3) of the optimal staffing cost. A key feature of our approach is that we allow hospitals to have two shift lengths. Our analytical results form the basis of a branch-and-bound algorithm, which we test on data obtained from three hospitals. Experiments show that rescheduling saves significant staffing costs. PMID:25687390

  20. Improved Search Techniques

    Science.gov (United States)

    Albornoz, Caleb Ronald

    2012-01-01

    Thousands of millions of documents are stored and updated daily in the World Wide Web. Most of the information is not efficiently organized to build knowledge from the stored data. Nowadays, search engines are mainly used by users who rely on their skills to look for the information needed. This paper presents different techniques search engine users can apply in Google Search to improve the relevancy of search results. According to the Pew Research Center, the average person spends eight hours a month searching for the right information. For instance, a company that employs 1000 employees wastes $2.5 million dollars on looking for nonexistent and/or not found information. The cost is very high because decisions are made based on the information that is readily available to use. Whenever the information necessary to formulate an argument is not available or found, poor decisions may be made and mistakes will be more likely to occur. Also, the survey indicates that only 56% of Google users feel confident with their current search skills. Moreover, just 76% of the information that is available on the Internet is accurate.

  1. PESTICIDE APPLICATION TECHNICS IMPROVEMENT

    Directory of Open Access Journals (Sweden)

    Đuro Banaj

    2011-06-01

    Full Text Available The academic textbook Pesticide application tehnics improvement is the result of several-year recording theoretical models, numerous practical tests, and data collection relating to technical systems in plant protection and its environment in the narrowest sense. In this first edition, the authors cover the area they have dealt with for many years. The authors aimed to present complete and clear methods how to solve specific problems in the agricultural practice management, plant protection, and direct practice application – ‘‘Know- How'', with as many as possible useful data. References used, along with local ones, are mostly American and from Western Europe. This textbook is intended for those who already use the agricultural technique in plant protection and those who are just acquiring the basics of technical systems proper application in daily practice, regardless the size of the agricultural farm. The authors covered in details and explained some bases of physics logic, analysis, and synthesis of specific laws while using pesticides due to extremely importance in understanding the problem area.

  2. Improving Project Manufacturing Coordination

    Directory of Open Access Journals (Sweden)

    Korpivaara Ville

    2014-09-01

    Full Text Available The objective of this research is to develop firms’ project manufacturing coordination. The development will be made by centralizing the manufacturing information flows in one system. To be able to centralize information, a deep user need assessment is required. After user needs have been identified, the existing system will be developed to match these needs. The theoretical background is achieved through exploring the literature of project manufacturing, development project success factors and different frameworks and tools for development project execution. The focus of this research is rather in customer need assessment than in system’s technical expertise. To ensure the deep understanding of customer needs this study is executed by action research method. As a result of this research the information system for project manufacturing coordination was developed to respond revealed needs of the stakeholders. The new system improves the quality of the manufacturing information, eliminates waste in manufacturing coordination processes and offers a better visibility to the project manufacturing. Hence it provides a solid base for the further development of project manufacturing.

  3. CONFORMANCE IMPROVEMENT USING GELS

    Energy Technology Data Exchange (ETDEWEB)

    Randall S. Seright

    2004-09-30

    This report describes work performed during the third and final year of the project, ''Conformance Improvement Using Gels.'' Corefloods revealed throughput dependencies of permeability reduction by polymers and gels that were much more prolonged during oil flow than water flow. This behavior was explained using simple mobility ratio arguments. A model was developed that quantitatively fits the results and predicts ''clean up'' times for oil productivity when production wells are returned to service after application of a polymer or gel treatment. X-ray computed microtomography studies of gels in strongly water-wet Berea sandstone and strongly oil-wet porous polyethylene suggested that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than gel-ripping or gel-displacement mechanisms. In contrast, analysis of data from the University of Kansas suggests that the gel-ripping or displacement mechanisms are more important in more permeable, strongly water-wet sandpacks. These findings help to explain why aqueous gels can reduce permeability to water more than to oil under different conditions. Since cement is the most commonly used material for water shutoff, we considered when gels are preferred over cements. Our analysis and experimental results indicated that cement cannot be expected to completely fill (top to bottom) a vertical fracture of any width, except near the wellbore. For vertical fractures with apertures less than 4 mm, the cement slurry will simply not penetrate very far into the fracture. For vertical fractures with apertures greater than 4 mm, the slurry may penetrate a substantial distance into the bottom part of the fracture. However, except near the wellbore, the upper part of the fracture will remain open due to gravity segregation. We compared various approaches to plugging fractures using gels, including (1) varying polymer content, (2) varying placement (extrusion) rate

  4. CONFORMANCE IMPROVEMENT USING GELS

    Energy Technology Data Exchange (ETDEWEB)

    Randall S. Seright

    2003-09-01

    This report describes work performed during the second year of the project, ''Conformance Improvement Using Gels.'' The project has two objectives. The first objective is to identify gel compositions and conditions that substantially reduce flow through fractures that allow direct channeling between wells, while leaving secondary fractures open so that high fluid injection and production rates can be maintained. The second objective is to optimize treatments in fractured production wells, where the gel must reduce permeability to water much more than that to oil. Pore-level images from X-ray computed microtomography were re-examined for Berea sandstone and porous polyethylene. This analysis suggests that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than a gel-ripping mechanism. This finding helps to explain why aqueous gels can reduce permeability to water more than to oil. We analyzed a Cr(III)-acetate-HPAM gel treatment in a production well in the Arbuckle formation. The availability of accurate pressure data before, during, and after the treatment was critical for the analysis. After the gel treatment, water productivity was fairly constant at about 20% of the pre-treatment value. However, oil productivity was stimulated by a factor of 18 immediately after the treatment. During the six months after the treatment, oil productivity gradually decreased to approach the pre-treatment value. To explain this behavior, we proposed that the fracture area open to oil flow was increased substantially by the gel treatment, followed by a gradual closing of the fractures during subsequent production. For a conventional Cr(III)-acetate-HPAM gel, the delay between gelant preparation and injection into a fracture impacts the placement, leakoff, and permeability reduction behavior. Formulations placed as partially formed gels showed relatively low pressure gradients during placement, and yet substantially reduced the

  5. Improving the bottom line

    International Nuclear Information System (INIS)

    With slower sales in North America and Europe, manufacturers are looking to supply power equipment in the expanding global markets. In doing so, they are finding opportunities and challenges. Competition is tougher in these markets; as well, each market has its own demands. Independent Energy recently spoke with a number of the top manufacturing companies and several system packagers about the markets for power equipment. The topics ranged from higher efficiencies and lower emissions on gas turbines to larger boilers. A growing need for cleaner combustion technologies in many emerging nations, are leading vendors to keep research and development (R ampersand D) budgets at the top of priority lists. In order to find ways to meet cleaner, more efficient demands, some of the equipment industry's leaders are renewing old partnerships and making new ones through alliances and joint ventures. Combining R ampersand D efforts and offering equipment delivery from points around the world instead of one central source is crucial to success in these expanding markets. As well, these alliances offer manufacturers the opportunity to find partners in the countries where much of the new power generation supply will be built. This makes doing business with local or state utilities - and developers who also are seeking local partners - less risky. At the same time, it offers opportunities for these companies to expand into new markets and provide equipment from a local level, boosting economic growth in emerging nations. As manufacturers adjust their market positions, they prepare themselves for an expanding world marketplace which demands more competitive, more efficient and constantly improving ways of doing business

  6. YOGA IMPROVES CARDIOVASCULAR PARAMETERS

    Directory of Open Access Journals (Sweden)

    Pramod P. Kadu

    2016-06-01

    Full Text Available ABSTRACT Yoga in ancient technique practices by sage for a desirable and healthy life. Yogic exercise and Pranayam may modulate cardiovascular function. To assess the cardiovascular parameter in control and study group. We selected 90 healthy volunteers between age group 35 – 50 years and divided into two groups. i Study group – 45 ii Control group – 45. Control group was not doing any type of exercise or yoga during 1 yr of period whereas yoga group did yogic exercise for 1 yr under supervision of yoga expert. In both the group heart rate SBP and DBP evaluate at 0, 6 and 12 month period. In control group heart rate, SBP, and DBP showed no significant change at 0, 6, and 12 month reading, whereas study group (yoga 81.96±5.65 showed significant decreased heart rate From 81.96 ±5.65 to 75.60 ± 3.44 at 6 month and 73.75 ± 11.36 at 12 month (p<0.001 SBP decreased from 128 ± 7.66 to 120.97 ± 4.21 at 6 month and 120.48± 3.86 at 12 months (p<0.001. DBP showed significant decreased from 88.44 ± 5.25 to 80.53 ± 3.44 at 6 months and 80.53 ± 2.53 at 12months (p<0.001. Yogic exercise and Pranayam done regularly at long term improve cardiovascular efficiency.

  7. COPD Discovery Might Improve Treatment

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_158852.html COPD Discovery Might Improve Treatment Study may help pinpoint ... will progress, a discovery they believe could improve COPD treatment. Their research might help doctors determine which ...

  8. Improving Doctor/Caregiver Communication

    Science.gov (United States)

    ... Month Friend: Living Independently Group Improving Doctor/ Caregiver Communications Helpful Ideas for Family Caregivers From NFCA There is much to be gained by improving communications between family caregivers and health care professionals, especially ...

  9. How to Improve Listening Ability

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Learners of English,especially beginners have troubles in understanding speechesby native speakers.Bur how to improve listening ability?Here I’d like to introduceyou some ways which might help you to improve you listening ability.

  10. Improved automobile gas turbine engine

    Science.gov (United States)

    Kofskey, M. G.; Katsanis, T.; Roelke, R. J.; Mclallin, K. L.; Wong, R. Y.; Schumann, L. F.; Galvas, M. R.

    1976-01-01

    Upgraded engine delivers 100 hp in 3500 lb vehicle. Improved fuel economy is due to combined effects of reduced weight, reduced power-to-weight ratio, increased turbine inlet pressure, and improved component efficiencies at part power.

  11. NCCDS configuration management process improvement

    Science.gov (United States)

    Shay, Kathy

    1993-01-01

    By concentrating on defining and improving specific Configuration Management (CM) functions, processes, procedures, personnel selection/development, and tools, internal and external customers received improved CM services. Job performance within the section increased in both satisfaction and output. Participation in achieving major improvements has led to the delivery of consistent quality CM products as well as significant decreases in every measured CM metrics category.

  12. Mechanisms that improve referential access*

    OpenAIRE

    Gernsbacher, Morton Ann

    1989-01-01

    Two mechanisms, suppression and enhancement, are proposed to improve referential access. Enhancement improves the accessibility of previously mentioned concepts by increasing or boosting their activation; suppression improves concepts’ accessibility by decreasing or dampening the activation of other concepts. Presumably, these mechanisms are triggered by the informational content of anaphors. Six experiments investigated this proposal by manipulating whether an anaphoric reference was made wi...

  13. Interstate Electrification Improvement Project

    Energy Technology Data Exchange (ETDEWEB)

    Puckette, Margaret [Shorepower Technologies, Hillsboro, OR (United States); Kim, Jeff [Shorepower Technologies, Hillsboro, OR (United States)

    2015-07-01

    The Interstate Electrification Improvement Project, publicly known as the Shorepower Truck Electrification Project (STEP), started in May 2011 and ended in March 2015. The project grant was awarded by the Department of Energy’s Vehicles Technology Office in the amount of $22.2 million. It had three overarching missions: 1. Reduce the idling of Class 8 tractors when parked at truck stops, to reduce diesel fuel consumption and thus U.S. dependence on foreign petroleum; 2. Stimulate job creation and economic activity as part of the American Reinvestment and Recovery Act of 2009; 3. Reduce greenhouse gas emissions (GHG) from diesel combustion and the carbon footprint of the truck transportation industry. The project design was straightforward. First, build fifty Truck Stop Electrification (TSE) facilities in truck stop parking lots across the country so trucks could plug-in to 110V, 220V, or 480VAC, and shut down the engine instead of idling. These facilities were strategically located at fifty truck stops along major U.S. Interstates with heavy truck traffic. Approximately 1,350 connection points were installed, including 150 high-voltage electric standby Transport Refrigeration Unit (eTRU) plugs--eTRUs are capable of plugging in to shore power1 to cool the refrigerated trailer for loads such as produce, meats and ice cream. Second, the project provided financial incentives on idle reduction equipment to 5,000 trucks in the form of rebates, to install equipment compatible with shore power. This equipment enables drivers to shut down the main engine when parked, to heat or cool their cab, charge batteries, or use other household appliances without idling—a common practice that uses approximately 1 gallon of diesel per hour. The rebate recipients were intended to be the first fleets to plug into Shorepower to save diesel fuel and ensure there is significant population of shore power capable trucks. This two part project was designed to complement each other by

  14. Anti-osteoporotic therapy in Denmark-predictors and demographics of poor refill compliance and poor persistence

    DEFF Research Database (Denmark)

    Hansen, Carrinna; Pedersen, Birthe D.; Konradsen, Hanne;

    2012-01-01

    , children living at home, living close to a university hospital, anti-osteoporotic therapy other than alendronate, number of drugs especially above three, pulmonary disease, collagen disease. CONCLUSION: The results suggest a need for improved support for patients to facilitate the interpretation...

  15. Framework for Patient Flow Improvement

    Directory of Open Access Journals (Sweden)

    S.V. Medina-León

    2014-07-01

    Full Text Available There has been much research where the flow of patients was improved, but most of this study is case-specific and only a few papers offer guidelines for patient flow analysis and improvement. In this study a general framework for the analysis and improvement of patient flow is presented, based on a literature review and on experience from a case study in a hospital in Mexico dealing with identifying improvement opportunities that reduced waiting times in the obstetrics/gynecology area of the emergency department. The framework involves an initial analysis using basic tools followed by the selection of a strategy based on system complexity; financial investment required and team participation. The alternative strategies considered were use of advanced analysis tools; use of kaizen events; or direct recommendations. The aim of the framework is to serve as guideline in patient flow improvement projects by helping select the most appropriate improvement path, resulting in project success.

  16. Quality improvement as an investment.

    Science.gov (United States)

    Weeks, William B

    2002-01-01

    Health care organizations are experiencing increasing internal and external pressures to improve the quality of care that they provide. However, there is not a framework that can be used to help understand the value of quality improvement projects and to prioritize competing projects. By understanding the current processes, costs and outcomes of care, enumerating the costs and benefits of change, anticipating the timing of the costs and benefits, and performing a financial analysis, quality improvement efforts can be evaluated as investments. Only by understanding and adapting to the financial environments in which health care organizations operate can continuous quality improvement in health care succeed. PMID:12512466

  17. Improved hyperspectral imaging technologies Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Improved hyperspectral imaging technologies could enable lower-cost analysis for planetary science including atmospheric studies, mineralogical investigations, and...

  18. Richard Rorty:From Anti-metaphysical Neo-Pragmatism to Rejection of Philosophy

    Directory of Open Access Journals (Sweden)

    M. Akrami

    2010-01-01

    Full Text Available Richard Rorty is a neo-Pragmatist philosopher. For three decades, he has attacked the traditional philosophy (from Plato to Kant as well as any other epistemology searching for truth or claiming to mirror the nature in his philosophical works. Rorty holds that, according to the history of philosophy in his reading, there is no final answer to the traditional questions concerning knowledge, truth, and representation. These questions, therefore, should be dissolved and denied. He maintains that knowledge is justified belief, justification, however, being not the consequence of some correspondence between the theory or the statement, but the consequence of conversation, social practice, group consensus, and social solidarity. Rorty also thinks that democracy has priority on philosophy, disagreeing with the thesis that philosophy is the foundation of the rest of culture.Despite of usefulness of some elements and implications of Rorty’s metaphilosophy (such as his emphasis on freedom, democracy, and pluralism as well as his insisting on philosophical humility and avoiding scientific pride, it is faced with several problems, including 1 ignoring the referential and realist features of language, 2 confusing interpretation and reality, 3 eliminating the border between objectivity and subjectivity, 4 interfering of public and private life, and 5 ignoring the need of science, culture, technology and, in particular, politics, in philosophy. The authors try to show and analyze some elements of these problems.

  19. Humpty Dumpty and the Metaphysical Poetry in the Twentieth-century Criticism

    Directory of Open Access Journals (Sweden)

    Carmen Gallo

    2015-11-01

    Full Text Available Il contributo intende analizzare due modalità di analisi e interpretazione della poesia, il new criticism e il new historicism, che pur diverse nel background pratico e ideologico della loro impostazione, sono state accademicamente egemoni per gran parte del secolo scorso, orientando in modo forte il consenso teorico e le politiche d’insegnamento, soprattutto in ambito angloamericano. A questo scopo, si ripercorrono diacronicamente le analisi testuali o le interpretazioni che critici di orientamenti diversi hanno offerto di un componimento di John Donne, The Canonization, diventato nel tempo uno dei più significativi terreni di scontro per l'opposizione e l'elaborazione delle nuove proposte teoriche.

  20. Category of time in Christian metaphysics: Gregory of Nyssa and Maximus the Confessor

    OpenAIRE

    Mikhaylov, Petr

    2015-01-01

    In the article a problem of time is posed as an object of Christian theological reflection developed in a complicated interweaving of philosophical, cultural and religious traditions of the Mediterranean civilization. A typology of the problem is established by a correlation of the category of time with different aspects of temporality – with eternity in Antiquity, with future in Modernity and with present in the thought of different authors belonging to different epochs. The most representat...

  1. The Metaphysical Subject as Background to the Early Wittgenstein"s Epistemology

    OpenAIRE

    Armstrong, Brian

    2003-01-01

    Proposition 4.1121 of the Tractatus states that epistemology is the philosophy of psychology. What should we take this to mean? Philosophy, on Tractarian terms, is an activity by which thoughts are clarified. This activity ranges from checking terms to see if they have meaning to investigating a network for its regularity. Epistemology, then, would be the philosophical analysis and clarification of any possible psychology, although it is not clear what a psychology on ...

  2. Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone

    OpenAIRE

    Baoli Wang; Hongting Jin; Bing Shu; Ranim R. Mira; Di Chen

    2015-01-01

    Bone marrow stromal cells/osteoblasts were originally thought to be the major player in regulating osteoclast differentiation through expressing RANKL/OPG cytokines. Recent studies have established that chondrocytes also express RANKL/OPG and support osteoclast formation. Till now, the in vivo function of chondrocyte-produced OPG in osteoclast formation and postnatal bone growth has not been directly investigated. In this study, chondrocyte-specific Opg transgenic mice were generated by using...

  3. Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone.

    Science.gov (United States)

    Wang, Baoli; Jin, Hongting; Shu, Bing; Mira, Ranim R; Chen, Di

    2015-01-01

    Bone marrow stromal cells/osteoblasts were originally thought to be the major player in regulating osteoclast differentiation through expressing RANKL/OPG cytokines. Recent studies have established that chondrocytes also express RANKL/OPG and support osteoclast formation. Till now, the in vivo function of chondrocyte-produced OPG in osteoclast formation and postnatal bone growth has not been directly investigated. In this study, chondrocyte-specific Opg transgenic mice were generated by using type II collagen promoter. The Col2-Opg transgenic mice showed delayed formation of secondary ossification center and localized increase of bone mass in proximal metaphysis of tibiae. TRAP staining showed that osteoclast numbers were reduced in both secondary ossification center and proximal metaphysis. This finding was further confirmed by in vitro chondrocyte/spleen cell co-culture assay. In contrast, the mineral apposition rates were not changed in Col2-Opg transgenic mice. TUNEL staining revealed more apoptotic hypertrophic chondrocytes in the growth plate of Col2-Opg mice. Flow cytometry analysis showed fewer RANK-expressing cells in the marrow of Col2a1-Opg mice, suggesting the role of OPG in blocking the differentiation of early mesenchymal progenitors into RANK-expressing pre-osteoclasts. Our results demonstrated that OPG expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation. PMID:26329493

  4. Descartes and the “metaphysical dualism”: Excesses in interpreting a classic

    OpenAIRE

    Ştefan Afloroaei

    2010-01-01

    The article focuses on one of the most serious accusations brought against Descartes and modern philosophy, namely “the dualism of substance”. The accusers claim that the human body and soul were viewed as completely separate; consequently, their relationship as such and the united being of man become incomprehensible. As has been shown above, the idea of the separation of the soul from the body did not originate with Descartes; it was formulated much earlier, and repeated by a disciple of De...

  5. The metaphysical mind in its physical environment: Religious implications of neuroscience

    Directory of Open Access Journals (Sweden)

    C.W. du Toit

    2002-11-01

    Full Text Available This article introduces ideas originating from different sciences of mind and the challenge they present to religion. In spite of overcoming the mind-body dualism, it seems that the mind-brain dualism still prevails. The mind-brain relation is discussed in the light of some models. Special attention is given to supervenient theories of mind. In light of this information the article investigates how the impact of these theories on religious experience. D’Aquili and Newberg’s explanation of extraordinary religious experience is discussed. It is concluded that the phenomenon of religion and religious experience are more than mere brain functions. The place of religion and the continued importance of religion and religious experience are confirmed.

  6. The metaphysical mind in its physical environment: Religious implications of neuroscience

    OpenAIRE

    C. W. du Toit

    2002-01-01

    This article introduces ideas originating from different sciences of mind and the challenge they present to religion. In spite of overcoming the mind-body dualism, it seems that the mind-brain dualism still prevails. The mind-brain relation is discussed in the light of some models. Special attention is given to supervenient theories of mind. In light of this information the article investigates how the impact of these theories on religious experience. D’Aquili and Newberg’s explanation of ext...

  7. Phenomenology as research method or substantive metaphysics? An overview of phenomenology's uses in nursing.

    Science.gov (United States)

    Earle, Vicki

    2010-10-01

    In exploring phenomenological literature, it is evident that the term 'phenomenology' holds rather different meanings depending upon the context. Phenomenology has been described as both a philosophical movement and an approach to human science research. The phenomenology of Husserl, Heidegger, Gadamer, and Merleau-Ponty was philosophical in nature and not intended to provide rules or procedures for conducting research. The Canadian social scientist, van Manen, however, introduced specific guidelines for conducting human science research, which is rooted in hermeneutic phenomenology and this particular method has been employed in professional disciplines such as education, nursing, clinical psychology, and law. The purpose of this paper is to explore the difference between the phenomenological method as described by van Manen and that of other philosophers such as Husserl, Heidegger, Gadamer, and Merleau-Ponty. In so doing, the author aims to address the blurred boundaries of phenomenology as a research method and as a philosophical movement and highlight the influence of these blurred boundaries on nursing knowledge development.

  8. From physics to metaphysics. A sociological reconstruction of the interpretation problem of the quantum theory

    International Nuclear Information System (INIS)

    The quantum theory represents one of the most fastidious and successful theory projects of the history of mankind. It is one, if not the universal theory of physics. The history of its interpretation and the discussion affects however by far more than only the field of theoretical physics. Such theory approach destroys ontological certainty. It calls the observer in question, and it lets us anticipate, what is to be expected, if we are employed in other fields with complex phenomena, which are infected with the observer problematics. As transclassical physics the quantum theory is so to say built on ''worlds without ground'' and disappoints by this the hope to be able to set themselves free from mind questions by physics or mathematics. Homologuously to the top forms of mystic reflexion the discussion about the interpretation of quantum physics can mediate an idea, what the mystery of the conditioned coproduction of system and environment - reflexion and world - can mean for us and possibly help us to become homelike in worlds without grounds. Hereby it becomes clear, that highly driven theory, which solves itself in its abstractions in a high degree from the live-worldly reality, stands not in contradiction to the possibility of knowledge of the world. On the contrary, at first a theory creation sufficiently elaborated and endowed with own internally conditioned consistency constraints represents the condition for the possibility of reflexion and gain of knowledge.

  9. On the Poverty of Philosophy: The Metaphysics of McLaren's "Revolutionary Critical Pedagogy"

    Science.gov (United States)

    Ellison, Scott

    2009-01-01

    In this essay, Scott Ellison examines a line of critical thought in educational theory that has unapologetically sought transcendence in the face contemporary social and political conditions. Under the banner of critical pedagogy, Peter McLaren sees this current period of globalization as representing a worldwide historical crisis requiring a…

  10. CARTILAGE HAIR HYPOPLASIA, METAPHYSEAL CHONDRODYSPLASIA TYPE MCKUSICK - DESCRIPTION OF 7 PATIENTS AND REVIEW OF THE LITERATURE

    NARCIS (Netherlands)

    VANDERBURGT, [No Value; HARALDSSON, A; OOSTERWIJK, JC; VANESSEN, AJ; WEEMAES, C; HAMEL, B

    1991-01-01

    We describe 7 cases of cartilage hair hypoplasia (CHH) with emphasis on the clinical and immunological aspects. The literature on CHH is reviewed and symptoms in 63 non-Amish cases are summarized. In this autosomal recessive disorder the immunodeficiency, hair abnormalities, and severity of skeletal

  11. From Metaphysics to Parapsychology: Chinese Stereotypes in Two (Spanish Modernist Short Stories

    Directory of Open Access Journals (Sweden)

    Siwen Ning

    2016-07-01

    Full Text Available This paper examines the narrative resources and literal treatments of two Chinese characters in two short-stories from the illustrated magazine La Ilustración Española y Americana, the first of which, published at the end of 19th century and, the second, at the beginning of 20th century. The purpose of this study is to demonstrate an evolution of the Chinese stereotype in Spanish literature in the context of the so-called fin de siècle.

  12. Advertising, Desire, and the Unified Field: A Metaphysical Perspective on Advertising.

    Science.gov (United States)

    Wesson, David A.

    Suggesting that ills said to be perpetrated by advertising are really attributes of a unified field of consciousness, this paper discusses the concept that advertising creates desire. The generally undisputed notion that advertising helps to create specific desires is distinguished from the criticism that advertising increases the level and…

  13. Metaphysics for an enlightened public: The controversy over monads in Germany, 1746-1748.

    Science.gov (United States)

    Broman, Thomas

    2012-03-01

    This essay analyzes the controversy that attended the prize essay question on monads proposed by the Berlin Academy of Sciences in 1746. The controversy was first touched off by an anonymous pamphlet published by the mathematician Leonhard Euler, the academy's most well known member, that attacked the doctrine of monads. It peaked with the awarding of the prize to Johann Heinrich Gottlob Justi, whose winning essay closely followed Euler's arguments. This essay discusses the controversy as one instance in a broader quarrel in the German academic community over the suitability of Christian Wolff's philosophy as the foundation for a broad range of academic disciplines, including natural philosophy. It also analyzes the controversy as displaying the central role of the periodical press in the emergent German public sphere. PMID:22655336

  14. Migraine and Metaphysics: Sentinels of science in nineteenth-century physics

    DEFF Research Database (Denmark)

    2010-01-01

    . These attempts were primarily directed against unfounded hypotheses trying to encompass the indefinite and all sorts of aprioristic knowledge, except mathematics. Either by emphasizing the formal aspects of science or linking the formalism to useful applications in the shape of physical models and demands......, if at all, yield a coherent worldview? In this article I will answer that question by looking at how a group of outspoken and influential Cantabrigian Wranglers were carving out intellectual, cultural and political space for themselves and their scientific endeavours while unremittingly patrolling...

  15. Nonossifying fibroma (metaphyseal fibrous defect) of the mandible in a 15-year-old boy.

    Science.gov (United States)

    Mannan, Abul Ala; Singh, N Gopendro; Al-Waheeb, Salah; Taher, Taher N; Mohammed, Emad El Din El Din

    2015-06-01

    We describe a rare case of nonossifying fibroma of the mandible in a 15-year-old boy who presented with a left mandibular swelling. Conventional imaging showed an expansile radiolucent lesion involving the angle and the body of the left mandible. The lesion was curetted, and a miniplate was implanted at the excision site. Microscopic examination of the removed specimen revealed a cellular lesion characterized by a proliferation of uniform spindle-shaped cells in a vague but prominent storiform pattern, which represented the classic appearance of nonossifying fibroma. Three months later, radiography detected a fracture of the implantation plate. The area was re-explored with curettage of the soft tissue, which on microscopy demonstrated findings similar to the initial curettage findings. Follow-up radiology revealed satisfactory healing of the jaw, and no further recurrence was seen 2 years after the initial surgery. We present this case to highlight the importance of recognizing nonossifying fibroma in the mandible, which can be easily confused with more common mandibular lesions. PMID:26053991

  16. METAPHYSICS OF MONEY IN THE WORKS OF HONORÉ DE BALZAC AND FYODOR DOSTOEVSKY

    Directory of Open Access Journals (Sweden)

    Boris N. Tarasov

    2015-11-01

    Full Text Available The author examines similarities and diff erences in the aesthetic interpretation of the theme of money in terms of social realism of Balzac and Christian realism of Dostoevsky. Such notions as “human mystery”, “a dark side of human nature”, the “ME law”, “the law of love” are introduced to achieve the aforementioned objective. As part of these notions, the article analyzes artistic types and refl ection of both writers and shows the equalizing, reducing, transforming and compensating functions of the monetary absolute, which becomes a common equivalent of human freedom and personality and creates conditions for a new inequality. The author reveals anthropologic consequences caused by dominating principles of utilitarianism and monetarist perception, highlighted in the novels by French and Russian writers, that facilitate perversion and inversion of a hierarchy of values, displacement of spiritual and moral fundamentals, mental impoverishment, entropy and nihilism in the degrading society

  17. Energy, Metaphysics, and Space: Ernst Mach's Interpretation of Energy Conservation as the Principle of Causality

    Science.gov (United States)

    Guzzardi, Luca

    2014-06-01

    This paper discusses Ernst Mach's interpretation of the principle of energy conservation (EC) in the context of the development of energy concepts and ideas about causality in nineteenth-century physics and theory of science. In doing this, it focuses on the close relationship between causality, energy conservation and space in Mach's antireductionist view of science. Mach expounds his thesis about EC in his first historical-epistemological essay, Die Geschichte und die Wurzel des Satzes von der Erhaltung der Arbeit (1872): far from being a new principle, it is used from the early beginnings of mechanics independently from other principles; in fact, EC is a pre-mechanical principle which is generally applied in investigating nature: it is, indeed, nothing but a form of the principle of causality. The paper focuses on the scientific-historical premises and philosophical underpinnings of Mach's thesis, beginning with the classic debate on the validity and limits of the notion of cause by Hume, Kant, and Helmholtz. Such reference also implies a discussion of the relationship between causality on the one hand and space and time on the other. This connection plays a major role for Mach, and in the final paragraphs its importance is argued in order to understand his antireductionist perspective, i.e. the rejection of any attempt to give an ultimate explanation of the world via reduction of nature to one fundamental set of phenomena.

  18. Richard Rorty: From Anti-metaphysical Neo-Pragmatism to Rejection of Philosophy

    Directory of Open Access Journals (Sweden)

    M Akrami

    2010-03-01

    Despite of usefulness of some elements and implications of Rorty’s metaphilosophy (such as his emphasis on freedom, democracy, and pluralism as well as his insisting on philosophical humility and avoiding scientific pride, it is faced with several problems, including 1 ignoring the referential and realist features of language, 2 confusing interpretation and reality, 3 eliminating the border between objectivity and subjectivity, 4 interfering of public and private life, and 5 ignoring the need of science, culture, technology and, in particular, politics, in philosophy. The authors try to show and analyze some elements of these problems.

  19. Physiology as the antechamber to metaphysics: the young William James's hope for a philosophical psychology.

    Science.gov (United States)

    Croce, P J

    1999-11-01

    In the 5 years before 1878, when his career in psychology was becoming established, William James wrote a series of notes and reviews assessing the work of many of the pioneers in the new field. Adopting a public and confident voice, even while he was privately still uncertain and searching, James criticized the dogmatism of positivist and idealist claims to the study of the human brain and mind. In his short writings of 1873-1877, James started to formulate his own middle path. His first steps on that path show that he did not reject either scientific or philosophic inquiry; instead, he viewed scientific knowledge as a way to understand philosophical questions more deeply. Saving his sharpest critiques for positivism, James endorsed scientific investigation without materialist assmptions. While his career in psychology was still only a hope, James treated science as a means toward humanist insight. PMID:11624576

  20. Metafísica e finitude em Sartre = Metaphysics and finitude in Sartre

    Directory of Open Access Journals (Sweden)

    Souza, Marcelo Prates de

    2014-01-01

    Full Text Available Este artigo busca compreender qual o estatuto que a ideia de fundamento recebe na filosofia de Sartre enquanto uma ontologia existencial, isto é, enquanto uma filosofia que compreende o homem em sua finitude. Para isso, procura realizar uma análise da presença da Metafísica, sobretudo em O Ser e o Nada, com relação ao problema metafísico desenvolvido na obra: o surgimento do nada no ser. Por fim, procura, por meio desta análise, compreender o estatuto da finitude na mesma obra

  1. On Goody, his critics, and beyond: Social metaphysics for literacy studies

    Directory of Open Access Journals (Sweden)

    Manuela Ungureanu

    2014-08-01

    Full Text Available I defend Jack Goody's approach to explaining expansive social and intellectual changes by pointing to the contributions of the technologies of communication, and specifically, of the use of writing (Goody 1987, 2000. I argue that conceptually driven approaches to social or human kinds contribute the clarifications needed to alleviate and respond to his critics’ concerns surrounding the notion of a literate society (Collins 1995, Finnegan 1999, Sawyer 2002, Bloch 2003. My defense of Goody also identifies and endorses a few main criteria and resources for the success of any satisfactory definition of the related notions of a literate society/literate mind.

  2. Currency and Essence. A Reflection on Economy and Metaphysics in Plato’s Republic

    Directory of Open Access Journals (Sweden)

    Alfonso Flórez

    2012-08-01

    Full Text Available The article inquires into the relation established in the Republic between the two meanings of ousia: property in the sense of possessions and wealth, and essence or substance. Besides the economic relations associated with loans, exchange, and interest, the paper examines the role of currency in the economy, with respect to ousia, as a means of dissociating wealth from possessions, thus achieving a degree of universality comparable to that of being itself.

  3. Genetics Home Reference: intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and ...

    Science.gov (United States)

    ... abnormal side-to-side curvature of the spine ( scoliosis ) or thinning of the bones ( osteoporosis ). Adrenal hypoplasia ... health conditions: Diagnostic Tests Drug Therapy Surgery and Rehabilitation Genetic Counseling Palliative Care Related Information How are ...

  4. "Lekta" and Inner Form as Loci of Sense in Metaphysics of Language

    Science.gov (United States)

    Lyanda-Geller, Olga V.

    2012-01-01

    This project seeks to answer the question whether it is possible to locate sense in language. I suggest that two theories seemingly unrelated to each other, one belonging to Ancient thought, and the other to modern Continental philosophy, give positive answer to the question. I focus on the concepts of "lekton" and "inner form"…

  5. Improving care at cystic fibrosis centers through quality improvement.

    Science.gov (United States)

    Kraynack, Nathan C; McBride, John T

    2009-10-01

    Quality improvement (QI) using a clinical microsystems approach provides cystic fibrosis (CF) centers the opportunity to make a significant positive impact on the health of their patients. The availability of center-specific outcomes data and the support of the Cystic Fibrosis Foundation are important advantages for these quality improvement efforts. This article illustrates how the clinical microsystems methodology can improve care delivery and outcomes by describing the gradual application of quality improvement principles over the past 5 years by the CF team at the Lewis Walker Cystic Fibrosis Center at Akron Children's Hospital in Akron, Ohio. Using the example of a project to improve the pulmonary function of the pediatric patients at our center as a framework, we describe the QI process from the initial team-building phase, through the assessment of care processes, standardization of care, and developing a culture of continuous improvement. We outline how enthusiastic commitment from physician leadership, clinical managers and central administration, the availability of coaches, and an appreciation of the importance of measurement, patient involvement, communication, and standardization are critical components for successful process improvement. PMID:19760542

  6. Substantial Improvements of Fuel Economy

    DEFF Research Database (Denmark)

    Jørgensen, Kaj; Nielsen, Lars H.

    1996-01-01

    The paper evaluates the scope for improving the energy and environmental impacts of road transport by means of electrical and hybrid propulsion. These technologies promise considerable improvements of the fuel economy compared to equivalent vehicles mas well as beneficial effects for the energy...... and traffic systems. A case study concerning passenger cars is analysed by means of computer simulation....

  7. An Improved Moving Mesh Algorithm

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    we consider an iterative algorithm of mesh optimization for finite element solution, and give an improved moving mesh strategy that reduces rapidly the complexity and cost of solving variational problems.A numerical result is presented for a 2-dimensional problem by the improved algorithm.

  8. Healthcare quality improvement programme improves monitoring of people with diabetes

    NARCIS (Netherlands)

    Denig, Petra

    2004-01-01

    Question. Does a healthcare quality improvement programme, incorporating education and claims-based feedback about practice-specific models of monitoring diabetes care, increase the regularity with which primary care physicians assess people with diabetes mellitus receiving Medicare benefits? Study

  9. Continuous quality improvement: improving hemodialysis catheter patency using urokinase.

    Science.gov (United States)

    Northsea, C

    1996-12-01

    Opportunities for improvements in patient outcomes through applied continuous quality improvement (CQI) programs are endless and exciting. Improving vascular access outcomes has been a long-standing clinical problem for hemodialysis patients and the nephrology team. During the past few years there has been a dramatic increase in the use of dialysis catheters as permanent accesses for hemodialysis patients. All hemodialysis with dialysis catheters are at risk for catheter occlusion. An innovative, 2-year CQI program was developed, implemented, and designed to improve dialysis catheter patency rates with the use of urokinase. The CQI program resulted in a number of clinical outcomes that were beneficial to the patients and dialysis staff, and were cost-effective to the program.

  10. Improvement in indirect magnetostriction measurements

    Science.gov (United States)

    Németh, S.; Kopasz, C.; Hargitai, C.

    1992-07-01

    The SAMR and AtS methods are simultaneously applied for determination magnetostriction constants to reduce the uncertainties in the interpretation of the quantities directly measured and to improve the accuracy in λ values determined.

  11. Process improvement in transfusion medicine.

    Science.gov (United States)

    Kopko, P M; Holland, P V

    1999-07-01

    Ongoing efforts to decrease costs in the clinical laboratory make continuous process improvement especially important in difficult economic times. Process improvement can result in decreased workload, cost savings, and increased customer satisfaction but is an abstract concept in and of itself. To illustrate the steps of process improvement, we applied them to our blood component retrieval policy. By identifying the problems with the current system, proposing and implementing solutions, and measuring the effects before and after revamping the process, we have been able to show impressive reductions in the number of component retrievals initiated, the number acted on, wasted components, and customer complaints, all of which translate into cost savings. Once the cycle is completed, it begins anew. There must always be continuous process improvement. PMID:10388909

  12. Process improvement in transfusion medicine.

    Science.gov (United States)

    Kopko, P M; Holland, P V

    1999-07-01

    Ongoing efforts to decrease costs in the clinical laboratory make continuous process improvement especially important in difficult economic times. Process improvement can result in decreased workload, cost savings, and increased customer satisfaction but is an abstract concept in and of itself. To illustrate the steps of process improvement, we applied them to our blood component retrieval policy. By identifying the problems with the current system, proposing and implementing solutions, and measuring the effects before and after revamping the process, we have been able to show impressive reductions in the number of component retrievals initiated, the number acted on, wasted components, and customer complaints, all of which translate into cost savings. Once the cycle is completed, it begins anew. There must always be continuous process improvement.

  13. Progress Report: Experimental Saltmarsh Improvement

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A series of recommendations for the improvement of the Parker River National Wildlife refuge salt marshes including mound constructions as well as plantings and...

  14. How to Improve Listening Ability

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    正Learners of English, especially beginners have troubles in understanding speeches by native speakers. Bur how to improve listening ability? Here I'd like to introduce you some ways which might help you to improve you listening ability. First of all, do things step by step. It is no good to listen to anything beyond your level. Don't choose too difficult materials. Secondly,

  15. Sustaining motivation for continuous improvement

    DEFF Research Database (Denmark)

    Jørgensen, Frances; Kofoed, Lise Busk

    2007-01-01

    The objective of this article is to explore possibilities for improving motivation for participation in Continuous Improvement (CI). Due to a number of issues, for example, challenges with measuring outcomes of CI activities on performance, the inherent slower, incremental rather than big bang...... for managers to motivate participation in CI. Further the paper contributes to development of CI theory by suggesting how elements of motivation theory may address the most common types of barriers to successful CI....

  16. Improved Bidirectional Exact Pattern Matching

    OpenAIRE

    Hussain, Iftikhar; Hassan Kazmi, Syed Zaki; Ali Khan, Israr; Mehmood, Rashid

    2013-01-01

    In this research, we present an improved version of Bidirectional (BD) exact pattern matching (EPM) algorithm to solve the problem of exact pattern matching. Improved-Bidirectional (IBD) exact pattern matching algorithm introduced a new idea of scanning partial text window (PTW) as well with the pattern to take decision of moving pattern to the right of partial text window. IBD algorithm compares the characters of pattern to selected text window (STW) from both sides simultaneously as BD....

  17. Improving efficiency in meat production.

    Science.gov (United States)

    Brameld, John M; Parr, Tim

    2016-08-01

    Selective breeding and improved nutritional management over the past 20-30 years has resulted in dramatic improvements in growth efficiency for pigs and poultry, particularly lean tissue growth. However, this has been achieved using high-quality feed ingredients, such as wheat and soya that are also used for human consumption and more recently biofuels production. Ruminants on the other hand are less efficient, but are normally fed poorer quality ingredients that cannot be digested by human subjects, such as grass or silage. The challenges therefore are to: (i) maintain the current efficiency of growth of pigs and poultry, but using more ingredients not needed to feed the increasing human population or for the production of biofuels; (ii) improve the efficiency of growth in ruminants; (iii) at the same time produce animal products (meat, milk and eggs) of equal or improved quality. This review will describe the use of: (a) enzyme additives for animal feeds, to improve feed digestibility; (b) known growth promoting agents, such as growth hormone, β-agonists and anabolic steroids, currently banned in the European Union but used in other parts of the world; (c) recent transcriptomic studies into molecular mechanisms for improved growth efficiency via low residual feed intake. In doing so, the use of genetic manipulation in animals will also be discussed. PMID:27087253

  18. Improving efficiency in meat production.

    Science.gov (United States)

    Brameld, John M; Parr, Tim

    2016-08-01

    Selective breeding and improved nutritional management over the past 20-30 years has resulted in dramatic improvements in growth efficiency for pigs and poultry, particularly lean tissue growth. However, this has been achieved using high-quality feed ingredients, such as wheat and soya that are also used for human consumption and more recently biofuels production. Ruminants on the other hand are less efficient, but are normally fed poorer quality ingredients that cannot be digested by human subjects, such as grass or silage. The challenges therefore are to: (i) maintain the current efficiency of growth of pigs and poultry, but using more ingredients not needed to feed the increasing human population or for the production of biofuels; (ii) improve the efficiency of growth in ruminants; (iii) at the same time produce animal products (meat, milk and eggs) of equal or improved quality. This review will describe the use of: (a) enzyme additives for animal feeds, to improve feed digestibility; (b) known growth promoting agents, such as growth hormone, β-agonists and anabolic steroids, currently banned in the European Union but used in other parts of the world; (c) recent transcriptomic studies into molecular mechanisms for improved growth efficiency via low residual feed intake. In doing so, the use of genetic manipulation in animals will also be discussed.

  19. Improvability of assembly systems II: Improvability indicators and case study

    Directory of Open Access Journals (Sweden)

    S.-Y. Chiang

    2000-01-01

    Full Text Available Based on the performance analysis technique developed in Part I, this paper presents improvability indicators for assembly lines with unreliable machines. In particular, it shows that assembly lines are unimprovable with respect to workforce re-distribution if each buffer is, on the average, close to being half full. These lines are unimprovable with respect to buffer capacity re-distribution if each machine is starved and blocked with almost equal frequency. In addition, the paper provides indicators for identification of bottleneck machines and bottleneck buffers. Finally, the paper reports on an application of these improvability indicators in a case study at an automotive components plant.

  20. Improving Case Discussion with an Improv Mind-Set

    Science.gov (United States)

    Aylesworth, Andy

    2008-01-01

    Improvisational comedy emphasizes collaboration over competition. This leads to creative ideas and solutions to problems. By establishing this "improv mind-set" in the business classroom, an instructor may be able to overcome some of the problems associated with the case method (e.g., shy students, dominating students). By doing so, the learning…

  1. Surviving Performance Improvement "Solutions": Aligning Performance Improvement Interventions

    Science.gov (United States)

    Bernardez, Mariano L.

    2009-01-01

    How can organizations avoid the negative, sometimes chaotic, effects of multiple, poorly coordinated performance improvement interventions? How can we avoid punishing our external clients or staff with the side effects of solutions that might benefit our bottom line or internal efficiency at the expense of the value received or perceived by…

  2. Improving Software Citation and Credit

    CERN Document Server

    Allen, Alice; DuPrie, Kimberly; Mink, Jessica; Nemiroff, Robert; Robitaille, Thomas; Shamir, Lior; Shortridge, Keith; Taylor, Mark; Teuben, Peter; Wallin, John

    2015-01-01

    The past year has seen movement on several fronts for improving software citation, including the Center for Open Science's Transparency and Openness Promotion (TOP) Guidelines, the Software Publishing Special Interest Group that was started at January's AAS meeting in Seattle at the request of that organization's Working Group on Astronomical Software, a Sloan-sponsored meeting at GitHub in San Francisco to begin work on a cohesive research software citation-enabling platform, the work of Force11 to "transform and improve" research communication, and WSSSPE's ongoing efforts that include software publication, citation, credit, and sustainability. Brief reports on these efforts were shared at the BoF, after which participants discussed ideas for improving software citation, generating a list of recommendations to the community of software authors, journal publishers, ADS, and research authors. The discussion, recommendations, and feedback will help form recommendations for software citation to those publishers...

  3. Improvement of foundation for inspection

    International Nuclear Information System (INIS)

    Japan Nuclear Energy Safety Organization has been carrying out improvement of inspection system for nuclear plants in Japan since 2003FY. The new inspection system was introduced into nuclear power plants in-2008FY. In this project, improvement of comprehensive plant performance assessment and management tool for the new inspection system are developed. In 2012FY, a trend analysis method of the plant performance was developed with reference to the IAEA literature. And the trend analysis was tried based on the results of the comprehensive plant performance assessment of all domestic plants except Fukushima-Daiichi Nuclear Power Station. In addition, the teaching materials for QMS training guideline were made. And improvement of a quality management system evaluation support tool was performed. (author)

  4. Improved BLAST for wireless communications

    Institute of Scientific and Technical Information of China (English)

    Li Yongzhao; Liao Guisheng; Wang Feng

    2006-01-01

    Bell layered space-time architecture (BLAST) is a multi-antenna communication structure with high spectrum efficiency, and it has found wide applications in LANs and WLANs. However, its performance is much poorer than those of other space-time coding approaches. In order to improve its performance, an improved BLAST based on RAKE receiving is investigated. The new system introduces orthogonal spreading sequences (OSS) into the transmitter while retains the basic structure of BLAST. The proposed receiver suppresses interferences from other antennas by the orthogonality contained in the received signals, and extracts information from each receiving antenna by using RAKE receiving principle to construct efficient statistic decision. Simulation results show that the improved system performs well over both frequency-flat and frequency-selective fading channels.

  5. Improvements in backscatter measurement devices

    International Nuclear Information System (INIS)

    Improvements in measuring the thickness of a coating on a substrate by the technique of backscattered particles are described. These improvements enable the measurements to be carried out continuously as an integral part of the coating production line and also permit measurements where the coated elements are separated from one another by a predetermined distance. The former is achieved by situating the backscatter probe and detector on the rim of the measurement wheel and rotating this wheel at a speed such that the coated element and probe are stationary relative to one another. The latter improvement is achieved by an indexing apparatus which automatically positions the probe beside a coated element. (U.K.)

  6. Baseline budgeting for continuous improvement.

    Science.gov (United States)

    Kilty, G L

    1999-05-01

    This article is designed to introduce the techniques used to convert traditionally maintained department budgets to baseline budgets. This entails identifying key activities, evaluating for value-added, and implementing continuous improvement opportunities. Baseline Budgeting for Continuous Improvement was created as a result of a newly named company president's request to implement zero-based budgeting. The president was frustrated with the mind-set of the organization, namely, "Next year's budget should be 10 to 15 percent more than this year's spending." Zero-based budgeting was not the answer, but combining the principles of activity-based costing and the Just-in-Time philosophy of eliminating waste and continuous improvement did provide a solution to the problem.

  7. Design improvements in TRIGA reactors

    International Nuclear Information System (INIS)

    There have been many design improvements to TRIGA reactor hardware in the past twelve years. One of the more important and most obvious improvements has been in the area of reactor instrumentation. The low profile, completely transistorized Mark III console was a great step forward in a low maintenance, high reliability instrumentation system. Other design improvements include the lazy susan specimen pickup assembly; the specimen container; an empty stainless steel fuel element which can be filled with samples and can be located anywhere in the core; the flexible fuel handling tool; a new fuel measuring tool design; the shock absorber on the adjustable transient rod drive; new testing and evaluation procedures on the thermocouples and other

  8. Motor activity improves temporal expectancy.

    Directory of Open Access Journals (Sweden)

    Lilian Fautrelle

    Full Text Available Certain brain areas involved in interval timing are also important in motor activity. This raises the possibility that motor activity might influence interval timing. To test this hypothesis, we assessed interval timing in healthy adults following different types of training. The pre- and post-training tasks consisted of a button press in response to the presentation of a rhythmic visual stimulus. Alterations in temporal expectancy were evaluated by measuring response times. Training consisted of responding to the visual presentation of regularly appearing stimuli by either: (1 pointing with a whole-body movement, (2 pointing only with the arm, (3 imagining pointing with a whole-body movement, (4 simply watching the stimulus presentation, (5 pointing with a whole-body movement in response to a target that appeared at irregular intervals (6 reading a newspaper. Participants performing a motor activity in response to the regular target showed significant improvements in judgment times compared to individuals with no associated motor activity. Individuals who only imagined pointing with a whole-body movement also showed significant improvements. No improvements were observed in the group that trained with a motor response to an irregular stimulus, hence eliminating the explanation that the improved temporal expectations of the other motor training groups was purely due to an improved motor capacity to press the response button. All groups performed a secondary task equally well, hence indicating that our results could not simply be attributed to differences in attention between the groups. Our results show that motor activity, even when it does not play a causal or corrective role, can lead to improved interval timing judgments.

  9. Motor activity improves temporal expectancy.

    Science.gov (United States)

    Fautrelle, Lilian; Mareschal, Denis; French, Robert; Addyman, Caspar; Thomas, Elizabeth

    2015-01-01

    Certain brain areas involved in interval timing are also important in motor activity. This raises the possibility that motor activity might influence interval timing. To test this hypothesis, we assessed interval timing in healthy adults following different types of training. The pre- and post-training tasks consisted of a button press in response to the presentation of a rhythmic visual stimulus. Alterations in temporal expectancy were evaluated by measuring response times. Training consisted of responding to the visual presentation of regularly appearing stimuli by either: (1) pointing with a whole-body movement, (2) pointing only with the arm, (3) imagining pointing with a whole-body movement, (4) simply watching the stimulus presentation, (5) pointing with a whole-body movement in response to a target that appeared at irregular intervals (6) reading a newspaper. Participants performing a motor activity in response to the regular target showed significant improvements in judgment times compared to individuals with no associated motor activity. Individuals who only imagined pointing with a whole-body movement also showed significant improvements. No improvements were observed in the group that trained with a motor response to an irregular stimulus, hence eliminating the explanation that the improved temporal expectations of the other motor training groups was purely due to an improved motor capacity to press the response button. All groups performed a secondary task equally well, hence indicating that our results could not simply be attributed to differences in attention between the groups. Our results show that motor activity, even when it does not play a causal or corrective role, can lead to improved interval timing judgments. PMID:25806813

  10. Engaged Research in Process Improvement

    DEFF Research Database (Denmark)

    Pries-Heje, Jan

    2010-01-01

    This keynote initiates from an example of engaged research; a Danish software house that made it from maturity level 1 to 5 in eight years. The organizational change implied at each step is discussed and a design theory of process improvement and change derived.......This keynote initiates from an example of engaged research; a Danish software house that made it from maturity level 1 to 5 in eight years. The organizational change implied at each step is discussed and a design theory of process improvement and change derived....

  11. Improving designer productivity. [artificial intelligence

    Science.gov (United States)

    Hill, Gary C.

    1992-01-01

    Designer and design team productivity improves with skill, experience, and the tools available. The design process involves numerous trials and errors, analyses, refinements, and addition of details. Computerized tools have greatly speeded the analysis, and now new theories and methods, emerging under the label Artificial Intelligence (AI), are being used to automate skill and experience. These tools improve designer productivity by capturing experience, emulating recognized skillful designers, and making the essence of complex programs easier to grasp. This paper outlines the aircraft design process in today's technology and business climate, presenting some of the challenges ahead and some of the promising AI methods for meeting these challenges.

  12. Improved Ternary Subdivision Interpolation Scheme

    Institute of Scientific and Technical Information of China (English)

    WANG Huawei; QIN Kaihuai

    2005-01-01

    An improved ternary subdivision interpolation scheme was developed for computer graphics applications that can manipulate open control polygons unlike the previous ternary scheme, with the resulting curve proved to be still C2-continuous. Parameterizations of the limit curve near the two endpoints are given with expressions for the boundary derivatives. The split joint problem is handled with the interpolating ternary subdivision scheme. The improved scheme can be used for modeling interpolation curves in computer aided geometric design systems, and provides a method for joining two limit curves of interpolating ternary subdivisions.

  13. Improved immunocytochemical detection of daunomycin

    DEFF Research Database (Denmark)

    Ohara, Koji; Shin, Masashi; Larsson, Lars-Inge;

    2007-01-01

    and mitochondria of heart muscle cells may help to improve our understanding of the cardiac toxicity of DM and related anthracyclin antibiotics. A number of ELISA tests were carried out in order to elucidate the mechanisms of H2O2-assisted antigen retrieval. A possible mechanism is that DM is reduced...... and converted to its semiquinone and/or hydroquinone derivative in vivo. Oxidation by hydrogen peroxide acts to convert these derivatives back to the native antigen. The improved ICC methodology using oxidation to recreated native antigens from reduced metabolites may be helpful also with respect to...

  14. Acute exercise improves motor memory

    DEFF Research Database (Denmark)

    Skriver, Kasper Christen; Roig, Marc; Lundbye-Jensen, Jesper;

    2014-01-01

    We have recently shown that a single bout of acute cardiovascular exercise improves motor skill learning through an optimization of long-term motor memory. Here we expand this previous finding, to explore potential exercise-related biomarkers and their association with measures of motor memory...... practice whereas lactate correlated with better retention 1 hour as well as 24 hours and 7 days after practice. Thus, improvements in motor skill acquisition and retention induced by acute cardiovascular exercise are associated with increased concentrations of biomarkers involved in memory and learning...... processes. More mechanistic studies are required to elucidate the specific role of each biomarker in the formation of motor memory....

  15. Improving Precision of Generated ASTs

    DEFF Research Database (Denmark)

    Winther, Johnni

    The parser-generator is an essential tool in grammarware and its output, the parse tree in form of the concrete or abstract syntax tree, often forms the basis for the whole structure of the grammarware application. Several tools for Java encode the parse tree in a class hierarchy generated to model...... the parsed documents closely within the Java type system. We present two algorithms used in the generation of such classes which improve the precision with which the parsed input is modeled and show that these improvements greatly ease the use of the generated classes....

  16. Windows with improved energy performances

    DEFF Research Database (Denmark)

    Laustsen, Jacob Birck; Svendsen, Svend

    2003-01-01

    Heat loss through windows represents a considerable part of the total heat loss from houses. However, apart from providing daylight access and view, windows offer a unique potential for solar gain to be exploited during the heating season. Until now valuation of the energy performance of windows...... with respect to the overall energy performance of windows. By selecting some of the best solutions a new low energy window has been developed for high latitude climates and a prototype manufactured. Simple and realistic improvements such as reducing the frame width and using glass with low iron content have...... be improved considerably in a fairly simple way without increasing the cost....

  17. Induced mutations for crop improvement

    International Nuclear Information System (INIS)

    Mutation induction has become an established tool in plant breeding to supplement existing germ plasma and to improve cultivars in certain specific traits. Hundreds of improved varieties have been released to farmers for many different crop species, demonstrating the economic value of the technology. Limitations arise mainly from the large mutagenized populations to be screened and from the unsatisfactory selection methods. Both limitations may be eased to some extent by advances in techniques of plant in-vitro culture. (author). Refs, 1 fig., 7 tabs

  18. Performance improvement - business excellence processes

    International Nuclear Information System (INIS)

    This presentation discusses Performance Improvement which is defined as 'the process of identifying and analyzing important organizational and individual performance gaps, planning for future performance improvement, designing and developing cost-effective and ethically justifiable intervention to close performance gaps, implementing the interventions and evaluating the financial and non-financial results', i.e. making things better. Specifically, it discusses the refurbishment outage at the Point Lepreau Power Plant that began at the end of March 2008. The business risks identified in 2008 were leadership, demographics and management system.

  19. Ways to Improve Oral English

    Institute of Scientific and Technical Information of China (English)

    张婧婧

    2015-01-01

    Speaking has been the bottom of the list in college English teaching since last few decades. This dissertation focus on this topic and it is mainly divided into following parts:Firstly, it analyses why college students make no significant progress in oral English. Secondly, it argues how to reform college English teaching to change this situation. It is concluded that teachers should em⁃phasize the importance of oral English in commercial lives and incent students to make great effort to improve speaking. Finally, ways to improve students' English speaking skill both in and outside the classroom are suggested.

  20. Improving quality of care through improved audit and feedback

    Directory of Open Access Journals (Sweden)

    Hysong Sylvia J

    2012-05-01

    Full Text Available Abstract Background The Department of Veterans Affairs (VA has led the industry in measuring facility performance as a critical element in improving quality of care, investing substantial resources to develop and maintain valid and cost-effective measures. The External Peer Review Program (EPRP of the VA is the official data source for monitoring facility performance, used to prioritize the quality areas needing most attention. Facility performance measurement has significantly improved preventive and chronic care, as well as overall quality; however, much variability still exists in levels of performance across measures and facilities. Audit and feedback (A&F, an important component of effective performance measurement, can help reduce this variability and improve overall performance. Previous research suggests that VA Medical Centers (VAMCs with high EPRP performance scores tend to use EPRP data as a feedback source. However, the manner in which EPRP data are used as a feedback source by individual providers as well as service line, facility, and network leadership is not well understood. An in-depth understanding of mental models, strategies, and specific feedback process characteristics adopted by high-performing facilities is thus urgently needed. This research compares how leaders of high, low, and moderately performing VAMCs use clinical performance data from the EPRP as a feedback tool to maintain and improve quality of care. Methods We will conduct a qualitative, grounded theory analysis of up to 64 interviews using a novel method of sampling primary care, facility, and Veterans Integrated Service Network (VISN leadership at high-, moderate-, and low-performing facilities. We will analyze interviews for evidence of cross-facility differences in perceptions of performance data usefulness and strategies for disseminating performance data evaluating performance, with particular attention to timeliness, individualization, and punitiveness