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Sample records for albumin excretion twin

  1. Sodium intake affects urinary albumin excretion especially in overweight subjects

    NARCIS (Netherlands)

    Verhave, J C; Hillege, H L; Burgerhof, J G M; Janssen, W M T; Gansevoort, R T; Navis, G J; de Zeeuw, D; de Jong, P E; Postma, Maarten

    2004-01-01

    Objectives. To examine the relationship between sodium intake and urinary albumin excretion, being an established risk marker for later cardiovascular morbidity and mortality. Design. Cross-sectional cohort study using linear regression analysis. Setting: University hospital outpatient clinic. Subje

  2. Urinary albumin excretion. An independent predictor of ischemic heart disease

    DEFF Research Database (Denmark)

    Borch-Johnsen, K; Feldt-Rasmussen, B; Strandgaard, S;

    1999-01-01

    Cross-sectional studies suggest that an increased urinary albumin excretion rate is associated with cardiovascular disease, dyslipidemia, and hypertension. The purpose of this study was to analyze prospectively whether the urinary albumin-to -creatinine (A/C) ratio can independently predict ische...

  3. Relationship Between Serum Adiponectin and Urinary Albumin Excretion Rate in Patients with Diabetes Nephropathy

    International Nuclear Information System (INIS)

    To explore the relationship between the levels of serum adiponectin and urinary albumin excretion rate in patients with type 2 diabetes nephropathy, the serum levels of adiponectin and the levels of urinary albumin excretion rate in diabetes patients before and after treatment with pioglitazone were tested by ELISA and automatic biochemical analyzer respectively. The results showed that the serum levels of adiponectin in DM and DN group were lower than that of normal controls(P<0.01), but they gradually increased with progression (P<0.01). The serum adiponectin level was positively correlated with urinary albumin excretion rate (r= 0.284, P<0.05). The urinary albumin level decreased (P<0.01) and the serum levels of adiponectin increased after treatment with pioglitazone in DN group. The serum levels of adiponectin and urinary albumin excretion rate may play important role in the indication of treatment of diabetes. (authors)

  4. Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

    DEFF Research Database (Denmark)

    Myrup, B; Hansen, P M; Jensen, T;

    1995-01-01

    We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU...... unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention....

  5. Ambulatory blood pressure and urinary albumin excretion in clinically healthy subjects

    DEFF Research Database (Denmark)

    Clausen, Peter Vilhelm; Jensen, J S; Borch-Johnsen, K;

    1998-01-01

    A slightly elevated urinary albumin excretion rate (UAER) is a predictor of atherosclerotic cardiovascular disease. The mechanism is unknown, but moderate office blood pressure elevation has been demonstrated as part of a clustering of known atherosclerotic risk factors in subjects with elevated...... increased urinary loss of albumin could not be solely related to the higher blood pressure. In conclusion, apparently healthy subjects with elevated UAER had slightly but significantly higher 24-hour systolic and diastolic blood pressure levels in addition to increased blood pressure loads but normal...... circadian variation. The demonstrated differences in blood pressure may offer a partial explanation for the association between elevated urinary albumin excretion and atherosclerotic cardiovascular risk....

  6. Effect of candesartan on microalbuminuria and albumin excretion rate in diabetes: three randomized trials

    DEFF Research Database (Denmark)

    Bilous, Rudy; Chaturvedi, Nish; Sjølie, Anne Katrin;

    2009-01-01

    , caregivers, and researchers were blinded to treatment assignment. During a median follow-up of 4.7 years, 793 patients discontinued therapy and 63 were lost to follow-up. MEASUREMENTS: Urinary albumin excretion rate, assessed annually by 2 overnight collections; if it was 20 microg/min or greater, then 2...... further collections were done. The primary end point was new microalbuminuria (3 or 4 collections of urinary albumin excretion rate >or=20 microg/min). The secondary end point was rate of change in albuminuria. RESULTS: Individual and pooled results of the 3 trials showed that candesartan had little...

  7. Low urinary albumin excretion in astronauts during space missions

    DEFF Research Database (Denmark)

    Cirillo, Massimo; De Santo, Natale G; Heer, Martina;

    2003-01-01

    BACKGROUND: Physiological changes occur in man during space missions also at the renal level. Proteinuria was hypothesized for space missions but research data are missing. METHODS: Urinary albumin, as an index of proteinuria, and other variables were analyzed in 4 astronauts during space missions......-two 24-hour urine collections were obtained in space (n per astronaut = 1-14) and on the ground (n per astronaut = 2-12). Urinary albumin was measured by radioimmunoassay. For each astronaut, mean of data in space and on the ground was defined as individual average. RESULTS: The individual averages of 24...... h urinary albumin were lower in space than on the ground in all astronauts; the difference was significant (mean +/- SD, space and on the ground = 3.41 +/- 0.56 and 4.70 +/- 1.20 mg/24 h, p = 0.017). Dietary protein intake and 24-hour urinary urea were not significantly different between space and...

  8. Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes

    DEFF Research Database (Denmark)

    Deckert, T; Yokoyama, H; Mathiesen, E;

    1996-01-01

    atherosclerotic vascular disease during follow up of 2457 person year. Elevated urinary albumin excretion was significantly predictive of atherosclerotic vascular disease (hazard ratio 1.06 (95% confidence interval 1.02 to 1.18) per 5 mg increase in 24 hour urinary albumin excretion, P = 0.002). Predictive effect...

  9. Normal urinary albumin excretion in recently diagnosed type 1 diabetic patients

    DEFF Research Database (Denmark)

    Lind, B; Jensen, T; Feldt-Rasmussen, B;

    1989-01-01

    The urinary excretion of albumin and retinol binding protein were measured in 51 recently diagnosed Type 1 diabetic patients and 48 control subjects, matched for age and sex. The diabetic patients, admitted consecutively to the Steno Memorial Hospital, were all studied 3 to 6 months after the ons...

  10. Endothelial haemostatic factors are associated with progression of urinary albumin excretion in clinically healthy subjects

    DEFF Research Database (Denmark)

    Clausen, P; Feldt-Rasmussen, B; Jensen, G;

    1999-01-01

    A slightly elevated urinary albumin excretion rate (UAER), above 5-10 microgram/min, is a predictor of atherosclerotic cardiovascular disease. Endothelial dysfunction is an important early feature of atherosclerosis. The plasma concentration of von Willebrand factor (vWF), a potential marker of e...

  11. What predicts progression and regression of urinary albumin excretion in the nondiabetic population?

    NARCIS (Netherlands)

    Brantsma, Auke H.; Atthobari, Jarir; Bakker, Stephan J. L.; de Zeeuw, Dick; de Jong, Paul E.; Gansevoort, Ronald T.

    2007-01-01

    An increase or decrease in urinary albumin excretion (UAE) is associated with, respectively, a higher or lower risk for renal and cardiovascular disease, independent of widely known cardiovascular risk factors. This study aimed to identify factors that are associated with changes in UAE in the nondi

  12. Urinary albumin excretion and the renin-angiotensin system in cardiovascular risk management

    NARCIS (Netherlands)

    Van de Wal, R. M. A.; Voors, A. A.; Gansevoort, R. T.

    2006-01-01

    Microalbuminuria has been shown to be a strong predictor of cardiovascular morbidity and mortality in diabetic and hypertensive patients, but also in the general population. Moreover, several reports suggest that reduction of urinary albumin excretion (UAE) is associated with improvement of cardiova

  13. Urinary albumin and beta 2-microglobulin excretion rates in patients with systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Parving, H H; Sørensen, S F; Mogensen, C E;

    1980-01-01

    The daily urinary albumin and beta 2-microglobulin excretion rates were measured with sensitive radioimmunoassays in 14 patients with systemic lupus erythematosus (SLE). The duration of SLE ranged from 0.5 to 18 years, mean 10 years. The mean age was 37 years. All patients except 5 received...

  14. Urinary albumin excretion in hospitalized patients with acute myocardial infarction. Prevalence of microalbuminuria and correlation to left ventricle wall thickness

    DEFF Research Database (Denmark)

    Taskiran, M; Feldt-Rasmussen, B; Jensen, G B;

    1998-01-01

    Microalbuminuria, a subclinical rise in the urinary albumin excretion, is a risk indicator of atherosclerotic cardiovascular disease. The aim of this study was to measure the urinary albumin excretion in patients with acute myocardial infarction, and to correlate this with known atherosclerotic...... was independent of blood pressure, body weight, smoking, diabetes mellitus, renal disease, and thrombolytic treatment. There was a positive correlation between urinary albumin excretion and thickness of the left ventricle wall (R = 0.28; p = 0.001) which was independent of blood pressure. Follow-up examination...... of the patients will reveal whether microalbuminuria increases the risk for recurrence of acute myocardial infarction....

  15. Predictors of angiotensin-converting enzyme inhibitor-induced reduction of urinary albumin excretion in nondiabetic patients.

    Science.gov (United States)

    van de Wal, Ruud M A; Gansevoort, Ron T; van der Harst, Pim; Boomsma, Frans; Thijs Plokker, H W; van Veldhuisen, Dirk J; de Jong, Paul E; van Gilst, Wiek H; Voors, Adriaan A

    2006-11-01

    Urinary albumin excretion is a predictor for cardiovascular mortality and morbidity. We investigated which parameters determine baseline urinary albumin excretion in nondiabetic subjects, without renal disease. In addition, we evaluated the parameters that predict the albuminuria-lowering efficacy of an angiotensin-converting enzyme inhibitor. In this substudy of the Prevention of Renal and Vascular Endstage Disease Intervention Trial, 384 microalbuminuric patients were included. Patient and biochemical characteristics were obtained at baseline and after 3 months of double-blinded, randomized treatment (fosinopril 20 mg or placebo). Mean age was 51.1+/-11.5 years, and 65.6% were male. Median urinary albumin excretion was 22.2 mg per 24 hours. At baseline, mean arterial pressure (beta(standardized)=0.161; P=0.006), urinary sodium excretion (beta(standardized)=0.154; P=0.011), and estimated renal function were independently associated with albumin excretion. In these predominantly normotensive to prehypertensive subjects, fosinopril reduced albumin excretion by 18.5% versus a 6.1% increase on placebo after 3 months (Poutspoken in subjects with higher baseline albumin excretion. Based on our data, we hypothesize that angiotensin-converting enzyme inhibition may result in superior cardiovascular protection when compared with other blood pressure-lowering agents in subjects with higher baseline levels of albuminuria. PMID:17000930

  16. Urinary albumin excretion and 24-hour blood pressure as predictors of pre-eclampsia in Type I diabetes

    DEFF Research Database (Denmark)

    Ekbom, P; Damm, P; Nøgaard, K;

    2000-01-01

    To evaluate the value of 24-h blood pressure monitoring compared to office blood pressure and urinary albumin excretion in predicting pre-eclampsia in Type I (insulin-dependent) diabetes mellitus.......To evaluate the value of 24-h blood pressure monitoring compared to office blood pressure and urinary albumin excretion in predicting pre-eclampsia in Type I (insulin-dependent) diabetes mellitus....

  17. Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats

    OpenAIRE

    Kim, Kyoungmi; Warden, Craig H.; Griffey, Stephen M; Vilches-Moure, Jose G.; Hansen, Susan; Cuppen, Edwin; Nijman, Isaäc J; Chiu, Sally; Stern, Judith S.

    2010-01-01

    We have previously shown that 90% of outbred obese Zucker Leprfa/fa rats die prematurely of renal disease. Thus, renal disease in obese Zucker Leprfa/fa rats may be caused by the LEPR mutation on chromosome 5, by the obesity, or it may be influenced by Zucker susceptibility alleles of genes on other chromosomes. We have searched for susceptibility genes on other chromosomes using urinary albumin excretion (UAE) as an early indicator of altered renal function in a backcross of (Brown Norway × ...

  18. Impaired aerobic work capacity in insulin dependent diabetics with increased urinary albumin excretion

    DEFF Research Database (Denmark)

    Jensen, T; Richter, E A; Feldt-Rasmussen, B;

    1988-01-01

    , age, and physical activity served as controls. Oxygen uptake was similar in the four groups at rest and during a 75 W workload. Maximal oxygen uptake was also similar in the control subjects and group 1 (median 41.7, (range 29.1-53.0) ml/kg/min v 38.5 (26.6-59.2) ml/kg/min, respectively...... were not explained by differences in metabolic control or the degree of autonomic neuropathy. Thus the insulin dependent diabetics with only slightly increased urinary albumin excretion had an appreciably impaired aerobic work capacity which could not be explained by autonomic neuropathy...

  19. Impaired aerobic work capacity in insulin dependent diabetics with increased urinary albumin excretion

    DEFF Research Database (Denmark)

    Jensen, T; Richter, Erik; Feldt-Rasmussen, Bo;

    1988-01-01

    To assess whether decreased aerobic work capacity was associated with albuminuria in insulin dependent diabetics aerobic capacity was measured in three groups of 10 patients matched for age, sex, duration of diabetes, and degree of physical activity. Group 1 comprised 10 patients with normal...... were not explained by differences in metabolic control or the degree of autonomic neuropathy. Thus the insulin dependent diabetics with only slightly increased urinary albumin excretion had an appreciably impaired aerobic work capacity which could not be explained by autonomic neuropathy...

  20. Association between urinary albumin excretion and intraocular pressure in type 2 diabetic patients without renal impairment.

    Directory of Open Access Journals (Sweden)

    Jin A Choi

    Full Text Available BACKGROUND: To assess the relationship between urinary albumin excretion and intraocular pressure (IOP in type 2 diabetes patients without renal impairment. METHODS: We explored the effects of albuminuria on high IOP in 402 non-glaucomatous type 2 diabetes without renal impairment who participated in the 2011 Korean National Health and Nutrition Examination Survey (KNHANES. Multiple logistic regression analysis was used to assess the relationship between log-transformed albumin/creatinine ratio (ACR tertiles and an IOP of ≥ 18 mmHg after adjusting for age, gender, hypertension, body mass index, triglycerides, area of residence, and education level. RESULTS: Subjects with a high IOP ≥ 18 mmHg were more likely to be current smokers (P = 0.038, heavy drinkers (P = 0.006, and to have high systolic blood pressure (P = 0.016, triglycerides (P = 0.008, and a higher log-transformed ACR (P = 0.022.In multivariate regression analysis, ACR tertile was associated with the prevalence of high IOP significantly (P = 0.022. The associations between ACR tertiles and high IOP were significant in overweight patients and those with abdominal obesity (P = 0.003 and 0.003, respectively. In contrast, there were no associations in the subgroup of patients who were not overweight and those without abdominal obesity (P = 0.291 and 0.561, respectively. CONCLUSIONS: Urinary albumin excretion is associated with high IOP in the type 2 diabetes population without renal insufficiency. The effect of the albuminuria on IOP was evident in a subgroup of patients with components of metabolic syndrome.

  1. Urinary albumin excretion rate is correlated with severity of coronary artery disease in elderly type 2 diabetic patients

    Institute of Scientific and Technical Information of China (English)

    GUO Li-xin; MA Jing; CHENG Yang; ZHANG Li-na; LI Ming

    2012-01-01

    Background Coronary heart disease is the main complication of type 2 diabetes mellitus; its incidence is closely related to microalbuminuria.The aim of this study was to investigate the correlation between the urinary albumin excretion rate and the incidence and severity of coronary heart disease in elderly type 2 diabetes mellitus patients.Methods A total of 612 hospitalized type 2 diabetes mellitus patients aged 60 years or older,who were given coronary angiography for diagnosis of possible coronary heart disease,participated.Their urinary albumin excretion rate was measured,and the severity of coronary artery stenosis was quantified with the Gensini scoring system to analyze the incidence of coronary heart disease and the severity of coronary artery stenosis.The optimal urinary albumin excretion rate predictive value for coronary heart disease incidence in elderly type 2 diabetes mellitus patients was determined.Results The incidence of coronary heart disease,the number of patients with coronary vascular disease and the Gensini scores were significantly different between the microalbuminuria group and the normal albuminuria group (P <0.05).The urinary albumin excretion rate was independently correlated with the occurrence of coronary heart disease in elderly type 2 diabetes mellitus patients (odds ratio (OR) =1.058,P <0.0001,95% confidence interval (CI): 1.036-1.080).Urinary albumin excretion rate and the Gensini score were independently correlated in elderly type 2 diabetes mellitus patients (β=0.476,P <0.0001).The best predictive value of urinary albumin excretion rate was 10.45 μg/min for elderly type 2 diabetes mellitus patients.The area under the curve was 0.764,with a sensitivity and specificity of 70.0% and 72.2%,respectively.Conclusions The occurrence of coronary heart disease in elderly type 2 diabetes mellitus patients with microalbuminuria was higher than that in patients with normal albuminuria,and the severity of the disease also

  2. Pattern of urinary albumin excretion in normotensive young and adolescent Indian women with polycystic ovary syndrome

    Directory of Open Access Journals (Sweden)

    Mohd Ashraf Ganie

    2012-01-01

    Full Text Available Objective: Polycystic ovarian syndrome (PCOS is a clinically heterogeneous endocrine disorder affecting up to 4-8% of women of reproductive age. The aim of this study was to evaluate the presence of microalbuminuria in women with PCOS and study its correlation with the various metabolic, clinical, and hormonal parameters. Materials and Methods: A cross-sectional study involving 69 PCOS women was carried out in a tertiary care center hospital. The diagnosis of PCOS was made according to the Rotterdam criteria. Blood samples were collected in the follicular phase of the menstrual cycle and analyzed for fasting luteinizing hormone (LH, follicle stimulating hormone (FSH, prolactin (PRL, 17-hydroxyprogesterone (17-OHP, total testosterone (T, glucose, insulin, and lipid profile. Urinary albumin was measured in the first void spot urine sample. Results: The mean age of the subjects was 22.0 ± 4.1 years and 21.8 ± 4.7 years in normoalbuminuric and microalbuminuric groups, respectively. Urinary albumin excretion (UAE varied from 5 mg/l to 100 mg/ml, with a median of 5 mg/l. Microalbuminuria was observed in 17/69 (24.6% of subjects. The mean UAE was 3.65 ± 4.44 mg/l in the normoalbuminuria group versus 45.29 ± 22.74 mg/l in the microalbuminuria group. Upon univariate analysis, hip circumference, diastolic blood pressure, and fasting blood glucose showed significant correlations with urinary albumin concentration (r = 0.264, 0.264, and 0.551, respectively; P = 0.028, 0.029, and 0.000, respectively. No association between UAE and the usual cardiovascular risk factors could be found upon regression analysis. Conclusion: About 24.6% of women with PCOS showed presence of microalbuminuria in the first void spot urine sample. Screening for the presence of microalbuminuria can help in early identification of a subset of PCOS women with a high risk for future CVD, who can be subjected to preventive strategies at the earliest. However, further studies are

  3. Kidney volume in type 1 (insulin-dependent) diabetic patients with normal or increased urinary albumin excretion

    DEFF Research Database (Denmark)

    Feldt-Rasmussen, B; Hegedüs, L; Mathiesen, E R;

    1991-01-01

    than 0.05). In a multiple linear regression with HbA1c, urinary albumin excretion, age, diabetes duration and mean blood pressure as independent variables, variations in HbA1c could account for 33% of the variations in kidney volume (n = 47, r = 0.57, p less than 0.01). The other variables played no...... improved metabolic control by means of insulin infusion pumps.(ABSTRACT TRUNCATED AT 250 WORDS)...

  4. Vitamin D Levels and Asymptomatic Coronary Artery Disease in Type 2 Diabetic Patients With Elevated Urinary Albumin Excretion Rate

    OpenAIRE

    Joergensen, Christel; Reinhard, Henrik; Schmedes, Anne; Hansen, Peter R; Wiinberg, Niels; Petersen, Claus L; Winther, Kaj; Parving, Hans-Henrik; Jacobsen, Peter K; Rossing, Peter

    2011-01-01

    OBJECTIVE Coronary artery disease (CAD) is the major cause of morbidity and mortality in type 2 diabetic patients. Severe vitamin D deficiency has been shown to predict cardiovascular mortality in type 2 diabetic patients. RESEARCH DESIGN AND METHODS We investigated the association among severe vitamin D deficiency, coronary calcium score (CCS), and asymptomatic CAD in type 2 diabetic patients with elevated urinary albumin excretion rate (UAER) >30 mg/24 h. This was a cross-sectional study in...

  5. Comparison of Acarbose and Metformin on Albumin Excretion in Patients With Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial.

    Science.gov (United States)

    Pan, Qingrong; Xu, Yuan; Yang, Ning; Gao, Xia; Liu, Jia; Yang, Wenying; Wang, Guang

    2016-04-01

    Increased urinary albumin excretion in diabetes not only signals nephropathy but also serves as a risk marker for cardiovascular disease. The data of MARCH (Metformin and AcaRbose in Chinese as the initial Hypoglycaemic treatment) trial demonstrated that acarbose and metformin were similarly efficacious at lowering blood glucose and blood pressure, as well as improving insulin sensitivity in Chinese patients newly diagnosed with type 2 diabetes mellitus. The purpose of this study was to identify the effects of acarbose and metformin therapy on albumin excretion in MARCH study.Baseline urine albumin/creatinine ratio (ACR) of 762 newly diagnosed, drug-naïve patients with type 2 diabetes mellitus was measured. Included patients were randomized to receive either acarbose or metformin and followed for 48 weeks. In addition to change in ACR, the estimated glomerular filtration rates (eGFR) and frequency of metabolic syndrome (MetS) were also assessed.Elevated ACR levels (≥30 mg/g) were present at baseline in 21.9% of all participants. A significant decline in urine ACR was observed in both the acarbose and metformin groups at week 24 and 48 (all P metformin (P = 0.01). Both acarbose and metformin significantly decreased the frequency of MetS at week 24 and 48 (both P metformin decreased urine ACR levels and reduced the frequency of elevated ACR and MetS in Chinese patients with newly diagnosed type 2 diabetes mellitus without affecting eGFR. After 48 weeks' intervention, acarbose therapy resulted in a greater reduction in urine ACR compared with metformin.

  6. Continuous versus intermittent exercise effects on urinary excretion of albumin and total protein.

    Science.gov (United States)

    Montelpare, W J; Klentrou, P; Thoden, J

    2002-09-01

    Several studies have reported post-exercise increases of urinary concentrations of plasma proteins. However, under normal conditions, through mechanisms of size and electrical charge selection, the kidney restricts the clearance of molecules as large as albumin. Post-exercise increases in albuminuria occur following the physiological stress of intense exercise, most likely as a result of the exercise induced blood acidity changes which lead to a change in the arrangement of the albumin molecule, and subsequently the filtration characteristics of the glomerular capillary wall. The purpose of the present study was therefore to determine the extent to which different types of exercise could induce a transient condition of post-exercise increases in the urinary output of total protein and albumin. All 14 males, who agreed to participate in the study, performed a continuous and an intermittent cycling protocol on a stationary bicycle ergometer. The results showed that: a) intermittent exercise had a greater influence than continuous exercise on the total output of urine albumin, and of urine total protein; b) concentrations of blood pH and blood lactate, were associated with changes in the clearance of urine albumin and urine total protein. Post-exercise proteinuria response seems to be transient and therefore renal trauma is not suspected at the early stages of observation. Furthermore, these results indicate that the kidney undergoes distinct physiological adjustments during exercise, and that these adjustments are relative to the intensity of the exercise stress. PMID:12413038

  7. LONG-TERM EFFECTS OF LINOLEIC-ACID-ENRICHED DIET ON ALBUMINURIA AND LIPID-LEVELS IN TYPE-1 (INSULIN-DEPENDENT) DIABETIC-PATIENTS WITH ELEVATED URINARY ALBUMIN EXCRETION

    NARCIS (Netherlands)

    DULLAART, RPF; BEUSEKAMP, BJ; MEIJER, S; HOOGENBERG, K; VANDOORMAAL, JJ; SLUITER, WJ

    1992-01-01

    We conducted a 2-year prospective randomised study to investigate the effects of a linoleic-acid-enriched diet on albuminuria and lipid levels in Type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion (overnight urinary albumin excretion rate between 10 and 200-mu-g/min

  8. Urinary albumin excretion in a population based sample of 1011 middle aged non-diabetic subjects. The Copenhagen City Heart Study Group

    DEFF Research Database (Denmark)

    Jensen, J S; Feldt-Rasmussen, B; Borch-Johnsen, K;

    1993-01-01

    Increased urinary albumin excretion rate (UAER) especially in the range of 20-200 micrograms min-1, termed microalbuminuria, has been proposed as a risk marker and predictor for cardiovascular disease in non-diabetic subjects. Thus it would be of importance to describe the distribution of UAER in...

  9. Elevated albumin excretion and retinal changes in children with type 1 diabetes are related to long-term poor blood glucose control

    DEFF Research Database (Denmark)

    Nørgaard, K; Storm, Birgit Kjærside; Graae, M;

    1989-01-01

    patients were proteinuric (greater than 300 mg 24 h-1) (2%). Retinal morphology was evaluated by colour fundus photography. Background retinopathy was more frequent in the group with elevated albumin excretion (71%) than in a matched normoalbuminuric group (20%, 2p less than 0.001). Long-term blood glucose...

  10. Predominantly vegetarian diet in patients with incipient and early clinical diabetic nephropathy: effects on albumin excretion rate and nutritional status.

    Science.gov (United States)

    Jibani, M M; Bloodworth, L L; Foden, E; Griffiths, K D; Galpin, O P

    1991-12-01

    Several studies have suggested that dietary protein quality may be an important determinant in the natural history of renal disease. We have therefore studied the effects of a predominantly vegetarian diet in eight patients with Type 1 diabetes mellitus and an albumin excretion rate (AER) in excess of 30 micrograms min-1. The AER was measured after an 8-week run-in period on the patient's usual diet, and again after 8 weeks of a predominantly vegetarian diet in which the proportion of vegetable protein was supplemented in order to minimize the reduction in total dietary protein intake. The median fractional albumin clearance fell during the study from an initial value of 188 x 10(-+) (range 58-810 x 10(-4)) at the end of the run-in period to 87 x 10(-4) (23-829 x 10(-4)) at the end of the period on low animal protein diet (difference 79 x 10(-4) (95% Cl 9-149 x 10(-4)), p less than 0.05). The AER then returned to values similar to those obtained at the beginning of the study after a further 8 weeks in those patients returning to their usual diet. No significant changes in blood glucose control or in arterial pressure were observed. A predominantly vegetarian diet may therefore have important beneficial effects on diabetic nephropathy without the need for a heavily restricted total protein intake.

  11. Urinary albumin excretion and history of acute myocardial infarction in a cross-sectional population study of 2,613 individuals

    DEFF Research Database (Denmark)

    Jensen, J S; Borch-Johnsen, K; Feldt-Rasmussen, B;

    1997-01-01

    infarction, in a major population sample. METHODS: The study was performed as a part of the 3rd Copenhagen City Heart Study, Denmark, 1992-1994, and included 2,613 participants aged 30-70 years, and without diabetes mellitus, renal or urinary tract disease or haematuria. The study programme included...... measurement of urinary albumin excretion rate, acquisition of information regarding previous acute myocardial infarction (verified by the Danish Hospital Register) and tobacco and alcohol consumption, 12-lead resting electrocardiogram, and measurement of blood pressure, body mass index, waist:hip ratio......, plasma concentrations of total cholesterol, HDL cholesterol and fibrinogen, serum albumin concentration and glomerular filtration rate. RESULTS: Among the participants, 3.6% presented with a history of acute myocardial infarction. There was a positive association between urinary albumin excretion rate...

  12. Total protein, albumin and low-molecular-weight protein excretion in HIV-positive patients

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    Campbell Lucy J

    2012-08-01

    Full Text Available Abstract Background Chronic kidney disease is common in HIV positive patients and renal tubular dysfunction has been reported in those receiving combination antiretroviral therapy (cART. Tenofovir (TFV in particular has been linked to severe renal tubular disease as well as proximal tubular dysfunction. Markedly elevated urinary concentrations of retinal-binding protein (RBP have been reported in patients with severe renal tubular disease, and low-molecular-weight proteins (LMWP such as RBP may be useful in clinical practice to assess renal tubular function in patients receiving TFV. We analysed 3 LMWP as well as protein and albumin in the urine of a sample of HIV positive patients. Methods In a cross-sectional fashion, total protein, albumin, RBP, cystatin C, and neutrophil gelatinase-associated lipocalin (NGAL were quantified in random urine samples of 317 HIV positive outpatients and expressed as the ratio-to-creatinine (RBPCR, CCR and NGALCR. Exposure to cART was categorised as none, cART without TFV, and cART containing TFV and a non-nucleoside reverse-transcriptase-inhibitor (TFV/NNRTI or TFV and a protease-inhibitor (TFV/PI. Results Proteinuria was present in 10.4 % and microalbuminuria in 16.7 % of patients. Albumin accounted for approximately 10 % of total urinary protein. RBPCR was within the reference range in 95 % of patients while NGALCR was elevated in 67 % of patients. No overall differences in urine protein, albumin, and LMWP levels were observed among patients stratified by cART exposure, although a greater proportion of patients exposed to TFV/PI had RBPCR >38.8 μg/mmol (343 μg/g (p = 0.003. In multivariate analyses, black ethnicity (OR 0.43, 95 % CI 0.24, 0.77 and eGFR 2 (OR 3.54, 95 % CI 1.61, 7.80 were independently associated with upper quartile (UQ RBPCR. RBPCR correlated well to CCR (r2 = 0.71, but not to NGALCR, PCR or ACR. Conclusions In HIV positive patients, proteinuria was predominantly of

  13. Urinary albumin excretion rate: a risk factor for retinal hard exudates in macular region in type 2 diabetic patients

    Institute of Scientific and Technical Information of China (English)

    Wang Shaocheng; Lin Siyong; Cao Xi; Zheng Yuezhong; Wang Jinyang; Lu Na; Yang Jinkui

    2014-01-01

    Background The various risk factors for retinal hard exudates are still poorly understood in type 2 diabetic patients.The aim of this study was to determine the association between urinary albumin excretion rate (UAER) and hard exudates in macular region in north Chinese patients.Methods A total of 272 patients (272 eyes) were enrolled for this study,including 154 subjects from group 1 (mild hard exudates),91 subjects from group 2 (moderate hard exudates) and 27 subjects from group 3 (severe hard exudates) confirmed using colour fundus photography,optical coherence tomography (OCT) as well as slit-lamp biomicroscopy with 78 diopter (D) lens.Each participant underwent a comprehensive assessment that included biochemical,clinical characteristics test and detailed ophthalmic evaluation.One-way analysis of variance (ANOVA) test and chi-square test were performed to analyze the fasting blood glucose (FBG),glycated hemoglobin (HbA1c),total cholesterol (TC),low density lipoprotein (LDL),high density lipoprotein (HDL),triglycerides (TG),full blood counts,urinary albumin excretion rate (UAER),blood creatinine (CREA),duration of diabetes,body mass index (BMI),systolic blood pressures (SBP) and diastolic blood pressures (DBP) between groups.Ordinal logistic regression analysis was further performed in order to eliminating the possible confounding factors.Results Three groups were matched in terms of age and gender.Risk factors which showed significant difference between groups include FBG (P <0.001),HbA1c (P <0.001),LDL (P <0.001),UAER (P <0.001),duration of diabetes (P=0.001),TC (P=0.005),SBP (P=0.026),CREA (P=0.004) and haemoglobin (Hb) (P=0.012).There was no significant difference between groups for the TG,HDL,DBP,platelet,total white blood cells and BMI.Using ordinal Logistic regression analyses,of all the variables,HbA1c,LDL and UAER which were independent risk factor for hard exudates showed a significantly odds ratio of 1.25,3.07,and 1.39,respectively

  14. Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements

    Science.gov (United States)

    Levitt, David G; Levitt, Michael D

    2016-01-01

    Serum albumin concentration (CP) is a remarkably strong prognostic indicator of morbidity and mortality in both sick and seemingly healthy subjects. Surprisingly, the specifics of the pathophysiology underlying the relationship between CP and ill-health are poorly understood. This review provides a summary that is not previously available in the literature, concerning how synthesis, catabolism, and renal and gastrointestinal clearance of albumin interact to bring about albumin homeostasis, with a focus on the clinical factors that influence this homeostasis. In normal humans, the albumin turnover time of about 25 days reflects a liver albumin synthesis rate of about 10.5 g/day balanced by renal (≈6%), gastrointestinal (≈10%), and catabolic (≈84%) clearances. The acute development of hypoalbuminemia with sepsis or trauma results from increased albumin capillary permeability leading to redistribution of albumin from the vascular to interstitial space. The best understood mechanism of chronic hypoalbuminemia is the decreased albumin synthesis observed in liver disease. Decreased albumin production also accounts for hypoalbuminemia observed with a low-protein and normal caloric diet. However, a calorie- and protein-deficient diet does not reduce albumin synthesis and is not associated with hypoalbuminemia, and CP is not a useful marker of malnutrition. In most disease states other than liver disease, albumin synthesis is normal or increased, and hypoalbuminemia reflects an enhanced rate of albumin turnover resulting either from an increased rate of catabolism (a poorly understood phenomenon) or enhanced loss of albumin into the urine (nephrosis) or intestine (protein-losing enteropathy). The latter may occur with subtle intestinal pathology and hence may be more prevalent than commonly appreciated. Clinically, reduced CP appears to be a result rather than a cause of ill-health, and therapy designed to increase CP has limited benefit. The ubiquitous occurrence of

  15. The Relationship Between Daytime, Nighttime and 24-Hour Heart Rate with Urinary Albumin and Protein Excretion in Patients with Newly Diagnosed Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Barış AFŞAR

    2012-05-01

    Full Text Available OBJECTIVE: Autonomic nervous system dysfunction (ASD has been widely observed in patients with type 2 diabetes. 24-hour ambulatory blood pressure (ABP and heart rate measurements have been found to associate with ASD in patient with Type 2 diabetes. Since albumin excretion is also related with ASD in type 2 diabetes; in the current study, the relationships between daytime, nighttime and 24- hour heart rates with 24 hour urinary albumin excretion (UAE and 24-hour urinary protein excretion (UPE were analyzed in patients with newly diagnosed type 2 diabetes. MATERIAL and METHODS: All patients underwent following procedures: history taking, physical examination, BP measurement, 12 lead electrocardiographic evaluations, routine urine analysis, biochemical analysis, 24-hour urine collection to measure UAE, UPE and creatinine clearance. 24-hour ABP and heart rate monitoring were performed for all patients. RESULTS: In total 80 patients with newly diagnosed type 2 diabetes were included. Stepwise linear regression revealed that logarithmically converted 24-hour UAE were independently related with 24- hour ambulatory SBP, (P:0.001 and heart rate (night (P<0.0001. Stepwise linear regression revealed that logarithmically converted 24-hour UPE were independently related with age (P:0.032, with averaged fasting blood glucose (P:0.023, with 24-hour ambulatory SBP, (P:0.002 and with heart rate (night (P:0.001. CONCLUSION: Nighttime heart rate, but not daytime and 24-hour heart rate was related with both 24-hour UAE and UPE in patients with Type 2 diabetes.

  16. Elevated NT-proBNP and coronary calcium score in relation to coronary artery disease in asymptomatic type 2 diabetic patients with elevated urinary albumin excretion rate

    DEFF Research Database (Denmark)

    Reinhard, Henrik; Hansen, Peter R; Persson, Frederik;

    2011-01-01

    Elevated plasma N-terminal (NT)-proBNP levels and coronary calcium score (CCS) not only predicts myocardial ischaemia and coronary artery stenosis but also adverse cardiovascular events and mortality in type 2 diabetic patients with an increased urinary albumin excretion rate (UAER), whereas low...... levels are associated with low frequency of coronary artery disease (CAD) and good prognosis. The underlying causes of poor prognosis in patients with elevated NT-proBNP are not known; thus, we investigated the role of putative asymptomatic CAD in type 2 diabetic patients with UAER >30 mg/24 h and...... elevated P-NT-proBNP and/or CCS....

  17. Autonomic neuropathy in nondiabetic offspring of type 2 diabetic subjects is associated with urinary albumin excretion rate and 24-h ambulatory blood pressure: the Fredericia Study

    DEFF Research Database (Denmark)

    Foss, Anne-Catherine; Vestbo, Else; Frøland, Anders;

    2001-01-01

    The aim of this study was to examine the impact of parental type 2 diabetes on the autonomic nervous system and to determine whether autonomic neuropathy is present and associated with changes in 24-h ambulatory blood pressure (AMBP) and urinary albumin excretion rate (UAER) in nondiabetic subjects......, Redmond, WA), and UAER was determined through three overnight urine samples. The subjects with parental type 2 diabetes had significantly lower heart rate variation in all three bedside tests (P diabetes. The prevalence of autonomic neuropathy in the nondiabetic...... offspring with parental type 2 diabetes (6.7%) was significantly (P neuropathy was associated with a higher fasting insulin level (P

  18. Elevated NT-proBNP and coronary calcium score in relation to coronary artery disease in asymptomatic type 2 diabetic patients with elevated urinary albumin excretion rate

    DEFF Research Database (Denmark)

    Reinhard, Henrik; Hansen, Peter R; Persson, Frederik;

    2011-01-01

    Elevated plasma N-terminal (NT)-proBNP levels and coronary calcium score (CCS) not only predicts myocardial ischaemia and coronary artery stenosis but also adverse cardiovascular events and mortality in type 2 diabetic patients with an increased urinary albumin excretion rate (UAER), whereas low...... levels are associated with low frequency of coronary artery disease (CAD) and good prognosis. The underlying causes of poor prognosis in patients with elevated NT-proBNP are not known; thus, we investigated the role of putative asymptomatic CAD in type 2 diabetic patients with UAER >30 mg/24 h...... and elevated P-NT-proBNP and/or CCS....

  19. Percentage of urinary albumin excretion and serum-free light-chain reduction are important determinants of renal response in myeloma patients with moderate to severe renal impairment

    International Nuclear Information System (INIS)

    Reversal of renal dysfunction significantly affects the prognosis of multiple myeloma (MM) with renal impairment (RI). There is no reliable test for predicting reversibility of RI in MM patients. We postulated that MM with high albuminuria may reflect glomerular disease that is difficult to reverse. Here, we examined the impact of urinary albumin excretion. We retrospectively analyzed 279 patients admitted to our hospital from April 2000 to December 2013. Clinical variables and laboratory data that may affect myeloma treatment response were extracted. The results were examined for relationship to renal response by univariate and multivariate analysis. RI (estimated glomerular filtration rate ≦50 ml/min per 1.73 m2) was observed in 116 patients (46%) and renal responses of renal complete response, renal partial response, renal minor response and no response were obtained in 46 (40%), 15 (13%), 13 (11%) and 42 (36%) patients, respectively. Although renal recovery was significantly associated with Durie–Salmon 1 or 2 (P=0.02), myeloma response better than very good partial response (P=0.03), involved free light-chain (iFLC) reduction from baseline 80% at day 12 (P=0.005), ≧95% at day 21 (P<0.001) and urinary albumin ≦25% on admission (P<0.001) on univariate analysis, only reduction of iFLC 95% at day 21 (P=0.015) and urinary albumin ≦25% (P=0.007) remained significant for any renal response. Our observation indicates that increased urinary albumin excretion >25% and reduction of iFLC ≦95% on day 21 were associated with favorable renal recovery in MM patients with RI, and were considered as negative predictors for renal response

  20. Association of Periodontitis With Urinary Albumin Excretion in Korean Adults With Diabetes: The 2012 Korea National Health and Nutrition Examination Survey.

    Science.gov (United States)

    Han, Kyungdo; Nam, Ga Eun; Kim, Do Hoon; Park, Jun-Beom; Ko, Youngkyung; Roh, Yong Kyun; Cho, Kyung Hwan; Park, Yong Gyu

    2015-10-01

    Albuminuria and periodontitis are both commonly associated with systemic inflammation. However, the association between urinary albumin excretion (UAE) and periodontitis in patients with type 2 diabetes has not been fully investigated. This study aimed to investigate the association between UAE and periodontitis in Korean adults with type 2 diabetes.This study performed a cross-sectional analysis and used hierarchical multivariable logistic regression analysis models. Data from the 2012 Korean National Health and Nutrition Examination Survey were analyzed. A total of 547 patients, with type 2 diabetes without renal impairment, were included in this study. UAE was assessed using the urinary albumin to creatinine ratio (UACR). A community periodontal index greater than or equal to code 3 was used to define periodontitis.The risk of periodontitis tended to increase as UACR increased even after adjustment for potential confounders (P for trend in the odds ratios = 0.05 in model 1; 0.02 in model 2; and 0.01 in model 3). In a subgroup analysis, the prevalence of periodontitis was significantly higher in the patients with albuminuria (UACR >30 mg/g) than in those without albuminuria among patients younger than 65 years (P = 0.03), those with newly diagnosed diabetes (P = 0.04), or those without obesity (P = .04).UAE was positively associated with the risk of periodontitis in Korean adults with type 2 diabetes. In the patients who were younger, were newly diagnosed with diabetes, or had normal body mass index, individuals with albuminuria were more likely to have a higher prevalence of periodontitis. Early identification of periodontitis may be helpful in Korean diabetic adults with increased UAE.

  1. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK- Mouse

    Directory of Open Access Journals (Sweden)

    Masako Furukawa

    2013-01-01

    Full Text Available Objective. Although angiotensin II-mediated inflammation and extracellular matrix accumulation are considered to be associated with the progression of diabetic nephropathy, these processes have not yet been sufficiently clarified. The objective of this study was to determine whether the correction of the abnormal renal expression of MMPs and its inhibitors (MMPs/TIMPs and cytokines following the administration of aliskiren to KK- mice results in a renoprotective effect. Methods. KK- mice were divided into two groups, that is, untreated (saline and treated (aliskiren groups. Systolic BP, HbA1c levels, and the albumin-creatinine ratio (ACR were measured. The renal expression of MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (prorenin receptor ((PRR was examined using real-time PCR and/or immunohistochemical staining. Renal MAPK and NF-κB activity were also examined by Western blot analyses and ELISA, respectively. Results. Significant decreases in systolic BP and ACR levels were observed in treated KK- mice compared with the findings in untreated KK- mice. Furthermore, increases in MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (PRR expression, in addition to MAPK and NF-κB activity, were significantly attenuated by aliskiren administration. Conclusions. It appears that aliskiren improves albuminuria and renal fibrosis by regulating inflammation and the alteration of collagen synthesis and degradation.

  2. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-Ay Mouse

    Science.gov (United States)

    Furukawa, Masako; Horikoshi, Satoshi; Funabiki, Kazuhiko; Tomino, Yasuhiko

    2013-01-01

    Objective. Although angiotensin II-mediated inflammation and extracellular matrix accumulation are considered to be associated with the progression of diabetic nephropathy, these processes have not yet been sufficiently clarified. The objective of this study was to determine whether the correction of the abnormal renal expression of MMPs and its inhibitors (MMPs/TIMPs) and cytokines following the administration of aliskiren to KK-Ay mice results in a renoprotective effect. Methods. KK-Ay mice were divided into two groups, that is, untreated (saline) and treated (aliskiren) groups. Systolic BP, HbA1c levels, and the albumin-creatinine ratio (ACR) were measured. The renal expression of MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (pro)renin receptor ((P)RR) was examined using real-time PCR and/or immunohistochemical staining. Renal MAPK and NF-κB activity were also examined by Western blot analyses and ELISA, respectively. Results. Significant decreases in systolic BP and ACR levels were observed in treated KK-Ay mice compared with the findings in untreated KK-Ay mice. Furthermore, increases in MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (P)RR expression, in addition to MAPK and NF-κB activity, were significantly attenuated by aliskiren administration. Conclusions. It appears that aliskiren improves albuminuria and renal fibrosis by regulating inflammation and the alteration of collagen synthesis and degradation. PMID:23819050

  3. A Disease Modification Effect of APOE E4 on the Association between Urinary Albumin Excretion and Cognition in Korean Adults

    Directory of Open Access Journals (Sweden)

    Min-Ho Shin

    2014-01-01

    Full Text Available Background. No previous study examined a disease modifying effect of APOE E4 status on the association between the urinary albumin-to-creatinine ratio (UACR and cognition. This study aimed to investigate whether APOE E4 modified the association in Korean adults. Methods. We performed a cross-sectional study in adults aged 45 to 74 who were living in Namwon City, Republic of Korea. Cognitive function was measured with the Korean version of modified Mini-Mental State Examination (K-mMMSE and cognitive impairment was defined as scores falling below the 25th percentile of the K-mMMSE according to age, sex, and educational attainments. Results. A total of 10,190 participants (4006 men and 6184 women were analyzed in the present study. Of these, 1698 subjects (16.7% were APOE E4 carriers. The UACR values were negatively associated with the K-mMMSE scores, even after adjusting for potential confounders including age, sex, education, and vascular risk factors. APOE E4 modified the association significantly, resulting in a steeper decline of cognitive function with the increase in UACR in E4 carriers (P for interaction = 0.021. Conclusion. Higher UACR values were significantly associated with cognitive dysfunction in the general Korean population, with cognition in APOE E4 carriers being more severely affected by increased UACR.

  4. Relationship between urinary albumin excretion rate and renal histology in non-insulin-dependent diabetes mellitus: with reference to the clinical significance of microalbuminuria.

    Science.gov (United States)

    Inomata, S; Nakamoto, Y; Inoue, M; Itoh, M; Ohsawa, Y; Masamune, O

    1989-01-01

    The present study demonstrates the relationship between urinary albumin excretion rate (AER) and renal structural changes in patients with non-insulin-dependent diabetes mellitus (NIDDM) without clinical proteinuria. Resting AER in 30 control subjects and 67 NIDDM patients were 10.4 +/- 4.8 (mean +/- SD) micrograms/min (range 4.3-21.1 micrograms/min) and 26.4 +/- 32.3 micrograms/min (range 0.4-155 micrograms/min), respectively. Persistent normoalbuminuria (less than 20 micrograms/min) and microalbuminuria (20-200 micrograms/min) were found in 43 (Group A) and 24 (Group B) diabetics. There were significant differences in age, diabetes duration, and frequency of retinopathy (background and proliferative) as well as that of proliferative retinopathy between Groups A and B, but not in the other clinical parameters such as body mass index, HbA1, Ccr, or systolic and diastolic blood pressure (SBP, DBP). When compared with 11 normoalbuminuric patients of similar age and equal diabetes duration to those in Group B, the sole difference in clinical parameters was the existence of proliferative retinopathy in Group B. Renal structural changes were investigated by light microscopy in 14 people in Group A and 13 people in Group B, and additionally in 5 NIDDM patients with both macroalbuminuria (greater than or equal to 200 micrograms/min) and normal or nearly normal renal function (Group C). The diffuse glomerular lesion (Gellman's classification) was grade I or II in A, II or III in B, and III in C.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Effect of losartan on urinary albumin excretion in experimental diabetic rats%氯沙坦对实验性糖尿病大鼠尿白蛋白排泄的影响

    Institute of Scientific and Technical Information of China (English)

    张冬梅; 钟惠菊; 周敏

    2000-01-01

    Objective To observe the effect of losartan on urinary albumin excretion in streptozotocin diabetic rats.Methods The following groups of rats were studied:normal control rats(NC),diabetic control rats (DC),diabetic rats treated with losartan 〔20mg/(kg*d)〕(DL) and diabetic rats treated with perindopril (2mg/(kg*d)〕(DP).Urinary albumin was observed at the 4th、8th、12th and 16th week.Results Urinary albumin excretion of diabetic rats treated with losartan or perindopril were significantly lower than that of diabetic untreated group (P<0.01).The effect was not different between losartan treated and perindopril treated rats.Conclusion The results suggested that losartan can reduce urinary albumin excretion in diabetic rats.%目的观察血管紧张素受体拮抗剂氯沙坦(losartan)对糖尿病大鼠尿白蛋白排泄的影响。方法雄性SD大鼠分为正常对照组(NC)、糖尿病对照组(DC)、糖尿病氯沙坦治疗组(DL)和糖尿病培哚普利治疗组(DP)。检测各组第4、8、12、16周尿白蛋白排泄的变化。结果 DL组较DC组尿白蛋白排泄显著下降(P<0.01),和DP组比较无显著性差异。结论血管紧张素受体拮抗剂氯沙坦能有效降低糖尿病大鼠尿白蛋白的排泄。

  6. 补充叶酸对妊娠期尿微量白蛋白排泄率的影响%Effect of folate supplementation on urinary albumin excretion rate in pregnancy

    Institute of Scientific and Technical Information of China (English)

    梁小丽

    2015-01-01

    Objective To observe the effect of folate supplementation on urinary albumin excretion rate of pregnant women in pregnancy. Methods 100 pregnant women with persral folate and 100 pregnant women without persral folate were randomly selected in our hospital. To select 3h morning urine with special sampling tube, to test the urinary albumin excretion rate with radioimmunoassay. Results The positive rate of urinary albumin excretion of pregnant women without persral folate was obviously higher than which of pregnant women with persral folate. Conclusion Folate supplementation in pregnancy could reduce the positive rate of urinary albumin excretion, could keep enough folate in blood, could reduce the accumulation of homocysteine which is metabolic intermediate of low methionine, could avoid the injury of vascular endothelial cells, could reduce the occurrence of complication in obstetrics department.%目的:观察孕期口服叶酸对孕妇尿微量白蛋白排泄率的影响。方法在来我院孕检的孕妇中随机抽取孕期有口服叶酸的孕妇100例与孕期从未口服叶酸的孕妇100例。分别收集3h晨尿并用专门的试管取样,用放射免疫分析法检测孕妇尿微量白蛋白的排泄率。结果孕期未口服叶酸的孕妇其尿微量白蛋白排泄率的阳性率较孕期有口服叶酸的孕妇其尿微量白蛋白排泄率明显增高。结论孕期补充叶酸可降低尿微量白蛋白排泄率的阳性率,提示孕期口服叶酸可保持血液中有足够的叶酸,可以降低蛋氨酸代谢的中间产物同型半胱氨酸在体内的堆积,避免血管内皮细胞的损伤,减少产科一些并发症的发生。

  7. Urinary albumin in space missions

    DEFF Research Database (Denmark)

    Cirillo, Massimo; De Santo, Natale G; Heer, Martina;

    2002-01-01

    Proteinuria was hypothesized for space mission but research data are missing. Urinary albumin, as index of proteinuria, was analyzed in frozen urine samples collected by astronauts during space missions onboard MIR station and on ground (control). Urinary albumin was measured by a double antibody...... radioimmunoassay. On average, 24h urinary albumin was 27.4% lower in space than on ground; the difference was statistically significant. Low urinary albumin excretion could be another effect of exposure to weightlessness (microgravity)....

  8. Hypoalbuminemia in Donors with Twin-Twin Transfusion Syndrome

    NARCIS (Netherlands)

    Verbeek, L.; Middeldorp, J. M.; Hulzebos, C. V.; Oepkes, D.; Walther, F. J.; Lopriore, E.

    2013-01-01

    Objective: To estimate the differences in albumin levels between donors and recipients with twin-twin transfusion syndrome (TTTS). Methods: We performed a matched case-control study including twin pairs with TTTS treated conservatively (conservative group) or with fetoscopic laser surgery (laser gro

  9. Excretion of iodine-123-hippuran, technetium-99m-red blood cells, and technetium-99m-macroaggregated albumin into breast milk

    International Nuclear Information System (INIS)

    The amount of radioactivity excreted in breast milk following three different nuclear medicine procedures on twelve nursing mothers has been measured. Some of this information has already been incorporated into the latest guidelines on suspension of feeding after maternal radiopharmaceutical administration. The overall radiation dose that the patients' babies would have sustained had breast feeding not been interrupted has been estimated as an effective dose equivalent. A model has been developed to describe the relationship between clearance of activity from the milk, time between expressions, and the fraction of milk expressed. Some simple guidance is given on calculation of suitable interruption times for any individual mother from counts on her milk samples

  10. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-A (y) Mouse.

    Science.gov (United States)

    Furukawa, Masako; Gohda, Tomohito; Hagiwara, Shinji; Tanimoto, Mitsuo; Horikoshi, Satoshi; Funabiki, Kazuhiko; Tomino, Yasuhiko

    2013-01-01

    Objective. Although angiotensin II-mediated inflammation and extracellular matrix accumulation are considered to be associated with the progression of diabetic nephropathy, these processes have not yet been sufficiently clarified. The objective of this study was to determine whether the correction of the abnormal renal expression of MMPs and its inhibitors (MMPs/TIMPs) and cytokines following the administration of aliskiren to KK-A (y) mice results in a renoprotective effect. Methods. KK-A (y) mice were divided into two groups, that is, untreated (saline) and treated (aliskiren) groups. Systolic BP, HbA1c levels, and the albumin-creatinine ratio (ACR) were measured. The renal expression of MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (pro)renin receptor ((P)RR) was examined using real-time PCR and/or immunohistochemical staining. Renal MAPK and NF- κ B activity were also examined by Western blot analyses and ELISA, respectively. Results. Significant decreases in systolic BP and ACR levels were observed in treated KK-A (y) mice compared with the findings in untreated KK-A (y) mice. Furthermore, increases in MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (P)RR expression, in addition to MAPK and NF- κ B activity, were significantly attenuated by aliskiren administration. Conclusions. It appears that aliskiren improves albuminuria and renal fibrosis by regulating inflammation and the alteration of collagen synthesis and degradation. PMID:23819050

  11. The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Ishida Hidenori

    2010-05-01

    Full Text Available Abstract Background To study the relationship between the intima-media thickness (IMT of the carotid artery and the stage of chronic kidney disease (CKD based on the estimated glomerular filtration rate (eGFR and diabetic nephropathy graded by the urinary albumin excretion (UAE in the patients with type 2 diabetes mellitus. Methods A cross-sectional study was performed in 338 patients with type 2 diabetes mellitus. The carotid IMT was measured using an ultrasonographic examination. Results The mean carotid IMT was 1.06 ± 0.27 mm, and 42% of the subjects showed IMT thickening (≥ 1.1 mm. Cerebrovascular disease and coronary heart disease were frequent in the patients with IMT thickening. The carotid IMT elevated significantly with the stage progression of CKD (0.87 ± 0.19 mm in stage 1, 1.02 ± 0.26 mm in stage 2, 1.11 ± 0.26 mm in stage 3, and 1.11 ± 0.27 mm in stage 4+5. However, the IMT was not significantly different among the various stages of diabetic nephropathy. The IMT was significantly greater in the diabetic patients with hypertension compared to those without hypertension. The IMT positively correlated with the age, the duration of diabetes mellitus, and the brachial-ankle pulse wave velocities (baPWV, and negatively correlated with the eGFR. In a stepwise multivariate regression analysis, the eGFR and the baPWV were independently associated with the carotid IMT. Conclusions Our study is the first report showing a relationship between the carotid IMT and the renal parameters including eGFR and the stages of diabetic nephropathy with a confirmed association between the IMT and diabetic macroangiopathy. Our study further confirms the importance of intensive examinations for the early detection of atherosclerosis and positive treatments for hypertension, dyslipidaemia, obesity, as well as hyperglycaemia are necessary when a reduced eGFR is found in diabetic patients.

  12. Albumin Test

    Science.gov (United States)

    ... be limited. Home Visit Global Sites Search Help? Albumin Share this page: Was this page helpful? Also known as: ALB Formal name: Albumin, serum Related tests: Liver Panel , Comprehensive Metabolic Panel , ...

  13. Urine Albumin and Albumin/ Creatinine Ratio

    Science.gov (United States)

    ... limited. Home Visit Global Sites Search Help? Urine Albumin and Albumin/Creatinine Ratio Share this page: Was this page ... known as: Microalbumin; ACR; UACR Formal name: Urine Albumin; Albumin-to-Creatinine Ratio Related tests: Albumin ; Creatinine ; ...

  14. Generation of Urinary Albumin Fragments Does Not Require Proximal Tubular Uptake

    OpenAIRE

    Weyer, K.; Nielsen, R; Christensen, E.I.; Birn, H

    2012-01-01

    Urinary albumin excretion is an important diagnostic and prognostic marker of renal function. Both animal and human urine contain large amounts of albumin fragments, but whether these fragments originate from renal tubular degradation of filtered albumin is unknown. Here, we used mice with kidneys lacking megalin and cubilin, the coreceptors that mediate proximal tubular endocytosis of albumin, to determine whether proximal tubular degradation of albumin forms the detectable urinary albumin f...

  15. Cubilin is an albumin binding protein important for renal tubular albumin reabsorption

    OpenAIRE

    Birn, H; J. C. Fyfe; Jacobsen, C; Mounier, F.; Verroust, P J; Orskov, H; Willnow, T. E.; Moestrup, S K; Christensen, E.I.

    2000-01-01

    Using affinity chromatography and surface plasmon resonance analysis, we have identified cubilin, a 460-kDa receptor heavily expressed in kidney proximal tubule epithelial cells, as an albumin binding protein. Dogs with a functional defect in cubilin excrete large amounts of albumin in combination with virtually abolished proximal tubule reabsorption, showing the critical role for cubilin in the uptake of albumin by the proximal tubule. Also, by immunoblotting and immunocytochemistry we show ...

  16. Detecting microalbuminuria by urinary albumin/creatinine concentration ratio

    DEFF Research Database (Denmark)

    Jensen, J S; Clausen, P; Borch-Johnsen, K;

    1997-01-01

    BACKGROUND: Microalbuminuria, i.e. a subclinical increase of the albumin excretion rate in urine, may be a novel atherosclerotic risk factor. This study aimed to test whether microalbuminuria can be identified by measurement of urinary albumin concentration or urinary albumin/creatinine concentra......BACKGROUND: Microalbuminuria, i.e. a subclinical increase of the albumin excretion rate in urine, may be a novel atherosclerotic risk factor. This study aimed to test whether microalbuminuria can be identified by measurement of urinary albumin concentration or urinary albumin....../creatinine concentration ratio, instead of the usual measurement of the albumin excretion rate in a timed urine collection. METHODS: All 2579 subjects analysed were screened in a population based epidemiological study. Participants with diabetes mellitus, renal disease, haematuria, or urinary tract infection were...... not included. Urinary albumin (Ualb) and creatinine (Ucreat) concentrations were measured in an overnight collected sample by enzyme-linked immunosorbent and colorimetric assays, respectively. Urinary albumin excretion rate (UAER) and urinary albumin/creatinine concentration ratio (Ualb/Ucreat) were calculated...

  17. Velocidad de la onda de pulso y la excreción urinaria de albumina en pacientes hipertensos tratados con Perindopril Pulse wave velocity and urinary albumin excretion in hypertensive patients treated with perindopril

    Directory of Open Access Journals (Sweden)

    J. E. Tobilli

    2002-12-01

    Full Text Available La presión arterial sistólica, la presión arterial diastólica y la excreción urinaria de albúmina (EUA han sido reconocidas como predictores de riesgo cardiovascular. Además, los trastornos de la compliance arterial (CA evaluados mediante la velocidad de la onda de pulso elevada (VOP están estrechamente relacionados con los cambios de la presión arterial y correlacionados con la mortalidad cardiovascular y la presencia de ateroesclerosis. El objetivo primario de este estudio ha sido determinar la relación entre la VOP y la EUA en un grupo de pacientes no fumadores con hipertensión esencial y secundariamente evaluar los cambios producidos por un inhibidor de la enzima convertidora de angiotensina (perindopril sobre estas dos variables. En el estudio participaron setenta pacientes (33 hombres y 37 mujeres hipertensos no fumadores, sin tratamiento previo, de 50 ± 7 años (entre 35-69. La VOP de todos los pacientes fue estudiada por medio de un dispositivo computarizado (Complior en el período basal y a los seis meses de tratamiento con perindopril. También se determinó la EUA por el método de inmunodifusión radial al inicio del tratamiento y luego de seis meses de tratamiento con perindopril (4.6 ± 1.4 mg/día. Al finalizar el estudio se observó una reducción significativa de la presión arterial sistólica (PAS (160.2 ± 10.6 vs. 131.9 ± 7.1 mmHg, pSystolic and diastolic blood pressures and urinary albumin excretion (UAE have been recognized as predictors for cardiovascular risk. Furthermore, arterial compliance (AC disorders assessed by increased aortic pulse wave velocity (PWV are closely related to changes in blood pressure and strongly correlated with cardiovascular mortality and presence or extent of atherosclerosis. Our purpose in the present study was to determine a relationship between AC using PWV and UAE in a group of non-smoking patients with essential hypertension, and the level of interaction of ACE inhibition on

  18. Twin RSA

    OpenAIRE

    Lenstra, Arjen K.; Weger, de, B.M.M.; Benjamin, M M

    2005-01-01

    We introduce Twin RSA, pairs of RSA moduli (n, n+ 2), and formulate several questions related to it. Our main questions are: is Twin RSA secure, and what is it good for? © Springer-Verlag Berlin Heidelberg 2005.

  19. [Adult twins].

    Science.gov (United States)

    Charlemaine, Christiane

    2006-12-31

    This paper explores the deep roots of closeness that twins share in their youngest age and their effect on their destiny at the adult age. Psychologists believe the bond between twins begins in utero and develops throughout the twins' lives. The four patterns of twinship described show that the twin bond is determined by the quality of parenting that twins receive in their infancy and early childhood. Common problems of adult twins bring about difficulties to adapt in a non-twin world. The nature versus nurture controversy has taken on new life focusing on inter-twin differences and the importance of parent-child interaction as fundamental to the growth and development of personality. PMID:17352324

  20. Heterotopic excretion of ioxitalamate

    Energy Technology Data Exchange (ETDEWEB)

    Koester, O.; Figge, M.

    1980-11-01

    The relatively rare case of heterotopic excretion of a recently introduced contrast medium easily excreted by the kidney, is demonstrated by means of 2 examples. In one case, the patient complained of colicky pain in the right flank, whereas tumour nephrectomy had been performed in the other patient. The hypotheses presented in medical literature regarding ectopic excretion of contrast medium, are mentioned, but it does not appear possible to safely explain the observed extrarenal excretions.

  1. Twin pregnancy

    DEFF Research Database (Denmark)

    Sperling, Lene; Tabor, A

    2001-01-01

    Determination of chorionicity is one of the most important issues in the management of twin pregnancy. Modern ultrasound equipment has made it possible to accurately assess placentation already in the first trimester with the lambda sign. With regard to prenatal diagnosis, it is important to know...... for clinicians caring for twin pregnancies....

  2. Urinary excretion of cadmium and zinc among persons from Sweden

    Energy Technology Data Exchange (ETDEWEB)

    Elinder, C.G.; Kjellstrom, T.; Linnman, L.; Pershagen, G.

    1978-06-01

    Cadmium and zinc concentrations in the urine of 132 Swedes, including 50 pairs of identical twins, were measured. Atomic absorption spectrophotometry procedures were developed for the analysis. Cadmium concentration increased with age and was higher among smokers than among nonsmokers. Estimated 24-hr excretion of cadmium among nonsmokers increased from about 0.25 to 0.40 ..mu..g in persons from 20 to 70 years old. The 24-hr cadmium excretions among nonsmokers in different age-groups fitted better to total kidney burden than to daily cadmium intake from food. Zinc excretion, on the other hand, decreased after the age of 20.

  3. Urinary porphyrin excretion in hepatitis C infection.

    Science.gov (United States)

    Vogeser, M; Jacob, K; Zachoval, R

    1999-08-01

    A high prevalence of hepatitis C virus infection in porphyria cutanea tarda in some populations suggests a close link between viral hepatitis and alteration of porphyrin metabolism. Moreover, there is evidence of a role of porphyrinopathies in hepatocarcinogenesis. The aim of our study was to obtain data on the prevalence and patterns of heme metabolism alterations in patients with chronic hepatitis C virus infection. Urinary porphyrin excretion was prospectively studied in 100 consecutive outpatients with chronic hepatitis C infection without signs of photosensitivity, using an ion-pair high-performance liquid chromatography method. Increased total porphyrin excretion was found in 41 patients, with predominant excretion of coproporphyrins (whole study group: mean 146 microg/g creatinine, interquartile range 76-186; normal coproporphyrin, heptacarboxyporphyrin III increased) but the total porphyrin excretion was only slightly elevated in this case. In the whole group, total urinary porphyrin excretion correlated well with serum bilirubin and was inversely correlated with albumin and thrombin time. In conclusion, secondary coproporphyrinuria occurs frequently in heptatitis C infection, whereas in Germany, preclinical porphyria cutanea tarda seems to be rare in these patients. PMID:10536928

  4. Nickel Dermatitis - Nickel Excretion

    DEFF Research Database (Denmark)

    Menné, T.; Thorboe, A.

    1976-01-01

    Nickel excretion in urine in four females -sensitive to nickel with an intermittent dyshidrotic eruption was measured with flameless atomic absorption. Excretion of nickel was found to be increased in association with outbreaks of vesicles. The results support the idea that the chronic condition...... was maintained by ingestion of nickel in food....

  5. Microalbuminuria reflects a generalized transvascular albumin leakiness in clinically healthy subjects

    DEFF Research Database (Denmark)

    Jensen, J S; Borch-Johnsen, K; Jensen, G;

    1995-01-01

    1. In epidemiological studies microalbuminuria, i.e. slightly elevated urinary albumin excretion rate, predicts increased atherosclerotic vascular morbidity and mortality. This study aimed to test the hypothesis that microalbuminuria in clinically healthy subjects is associated with a systemic...

  6. Rapidly reversible albumin and beta 2-microglobulin hyperexcretion in recent severe essential hypertension

    DEFF Research Database (Denmark)

    Christensen, Cramer

    1983-01-01

    with ensuing fall in blood pressure was rapidly and almost completely reversible in all but one patient during conventional treatment and the increased beta 2-microglobulin excretion was totally reversible in all but one patient. Both albumin and beta 2-microglobulin excretion rate were positively correlated......Seven young patients with newly diagnosed severe hypertension were studied for one week. The mean age was 34.9 years (range 28-44). The mean initial values +/- s.d. for systolic and diastolic pressures were 223 +/- 27 and 141 +/- 8 mmHg, respectively. Secondary hypertension was excluded...... by conventional methods and serum creatinine was normal. A pronounced but quite variably elevated albumin excretion 440 +/- 448 micrograms/min (mean +/- s.d.) and a moderately increased beta 2-microglobulin excretion 3.06 +/- 3.29 micrograms/min was noted before treatment. The abnormal albumin excretion...

  7. Transcapillary escape rate of albumin in hypertensive patients with type 1 (insulin-dependent) diabetes mellitus

    DEFF Research Database (Denmark)

    Nørgaard, K; Jensen, T; Feldt-Rasmussen, B

    1993-01-01

    . The systemic blood pressure and the transcapillary escape rate of albumin were measured in the following groups after 4 weeks without antihypertensive treatment: Group 1--eleven healthy control subjects. Group 2--ten Type 1 (insulin-dependent) diabetic patients with incipient nephropathy (urinary albumin...... excretion rate: 30-300 mg/24 h) and normal blood pressure. Group 3--eleven non-diabetic patients with essential hypertension. Group 4--nine Type 1 diabetic patients with hypertension but normal urinary albumin excretion (Group 5--eleven Type 1 diabetic patients with nephropathy (urinary......Diabetic patients with elevated urinary albumin excretion rate (incipient or clinical nephropathy) also have an increased transcapillary escape rate of albumin. This study was designed to clarify whether this is caused by a general vascular dysfunction or by elevated systemic blood pressure...

  8. Twin Baryogenesis

    CERN Document Server

    Farina, Marco; Shin, Chang Sub

    2016-01-01

    In the context of Twin Higgs models, we study a simple mechanism that simultaneously generates asymmetries in the dark and visible sector through the out-of-equilibrium decay of a TeV scale particle charged under a combination of baryon and twin baryon number. We predict the dark matter to be a 5 GeV twin baryon, which is easy to achieve because of the similarity between the two confinement scales. Dark matter is metastable and can decay to three quarks, yielding indirect detection signatures. The mechanism requires the introduction of a new colored particle, typically within the reach of the LHC, of which we study the rich collider phenomenology, including prompt and displaced dijets, multi-jets, monojets and monotops.

  9. Albumin and multiple sclerosis.

    Science.gov (United States)

    LeVine, Steven M

    2016-01-01

    Leakage of the blood-brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue where it is exposed to an inflammatory milieu and tissue damage, e.g., demyelination. Once in the CNS, albumin can participate in protective mechanisms. For example, due to its high concentration and molecular properties, albumin becomes a target for oxidation and nitration reactions. Furthermore, albumin binds metals and heme thereby limiting their ability to produce reactive oxygen and reactive nitrogen species. Albumin also has the potential to worsen disease. Similar to pathogenic processes that occur during epilepsy, extravasated albumin could induce the expression of proinflammatory cytokines and affect the ability of astrocytes to maintain potassium homeostasis thereby possibly making neurons more vulnerable to glutamate exicitotoxicity, which is thought to be a pathogenic mechanism in MS. The albumin quotient, albumin in cerebrospinal fluid (CSF)/albumin in serum, is used as a measure of blood-CSF barrier dysfunction in MS, but it may be inaccurate since albumin levels in the CSF can be influenced by multiple factors including: 1) albumin becomes proteolytically cleaved during disease, 2) extravasated albumin is taken up by macrophages, microglia, and astrocytes, and 3) the location of BBB damage affects the entry of extravasated albumin into ventricular CSF. A discussion of the roles that albumin performs during MS is put forth. PMID:27067000

  10. Improved metabolic control does not alter the charge-dependent glomerular filtration of albumin in uncomplicated type 1 (insulin-dependent) diabetes

    DEFF Research Database (Denmark)

    Kverneland, A; Welinder, B; Feldt-Rasmussen, B;

    1988-01-01

    The selectivity index, i.e. clearance of non glycated albumin/clearance of glycated albumin was studied in fourteen patients with Type 1 (insulin-dependent) diabetes and normal urinary albumin excretion. The index was increased above one in all patients, and correlated significantly to HbA1c. It ...

  11. Effect of angiotensin on glomerular filtration of albumin.

    Science.gov (United States)

    Eisenbach, G M; Van Liew, J B

    1975-01-01

    Angiotensin-induced proteinuria was examined at the glomerular-tubular level in rats. Ultra-micro-disc electrophoresis was employed to determine albumin concentration of rat proximal tubular fluid samples under control conditions and during the infusion of 0.15 mug/min X 100 g body weight angiotensin II using micropuncture techniques. Under control conditions proximal tubular albumin concentration was 1.32 +/- 0.79 (SD) mg/100 ml (n = 71). There was no correlation between albumin concentration and (TF/P)-inulin ratio indicating an albumin reabsorption in the proximal tubule parallel to fluid reabsorption under control conditions. During angiotensin infusion using re-collection techniques, there is an average increase of 26 times in tubular albumin concentration, indicating an increase in albumin filtered. There was no change in GFR, SNGFR, transit time, (TF/P)-inulin ratio, an increase in urine flow rate, sodium excretion, protein excretion, mean arterial blood pressure during angiotensin infusion. Since effective glomerular filtration pressure was not increased during angiotensin it is concluded that angiotensin-induced proteinuria is due to an increase in filtered protien mediated by a change in glomerular permeability to proteins.

  12. Increased urinary orosomucoid excretion

    DEFF Research Database (Denmark)

    Christiansen, M S; Iversen, K; Larsen, C T;

    2009-01-01

    OBJECTIVE: In a previous study, urinary orosomucoid excretion rate (UOER) independently predicted cardiovascular mortality in patients with type 2 diabetes. The aim of the present study was to determine whether increased UOER is associated with cardiovascular risk factors such as inflammation, im...

  13. Relationship of urinary albumin excretion rate with high sensitive C-reactive protien and uric acid in elderly patients with type 2 diabetes mellitus%老年2型糖尿病患者尿蛋白排泄率与高敏C反应蛋白、血尿酸水平关系分析

    Institute of Scientific and Technical Information of China (English)

    樊华

    2012-01-01

    目的 探讨老年2型糖尿病(T2DM)患者尿蛋白排泄率(UAER)与高敏C反应蛋白(hs-CRP)、血尿酸(UA)水平的关系. 方法 根据UAER将94例老年T2DM患者分为3组,正常蛋白尿组(A组)、微量蛋白尿组(B组)和大量蛋白尿组(C组).分别测定3组的hs-CRP、UA水平以及血压、血糖、血脂等相关临床生化指标,并进行比较. 结果 B组和C组hs-CRP、UA明显高于A组,B组和C组间也有统计学差异(P<0.05或P<0.01).3组间在年龄、病程、血压、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)和高密度脂蛋白胆固醇(HDL-C)方面也存在显著性差异(P<0.05或P<0.01).相关性分析显示,UAER与hs-CRP、UA均呈正相关(分别为r=0.331,P<0.01;r=0.254,P<0.05). 结论 hs-CRP和UA与老年糖尿病肾病(DN)的发生明显相关,在老年DN的预测中有一定临床意义.%Objective To explore the relationship of urinary albumin excretion rate(UAER) with high sensitive C-reactive protien( hs-CRP) ,uric acid(UA) in elderly patients with type 2 diabetes mellitus(T2DM). Methods According to the level of UAER,94 elderly patients with T2DM were divided into three groups; nomal albuminuria group ( A group) , microalbuminuria group ( B group) and macroalbuminuria group (C group). The levels of hs-CRP, UA and related clinical biochemical index,such as blood pressure(BP) , plasma glucose, blood lipid and so on were detected and compared. Results The levels of hs-CRP,UA in group B and group C were significantly higher than those in group A, and signifcant difference was also found between group B and group C ( P < 0. 05 or P<0.01). There was signifcant difference in average age, course of disease, BP, FPG, HbAlc, TC ,TG and HDL-C among three groups (P<0.05 or P<0.01) . Linear correlation showed that UAER level in T2DM patients was positively related to hs-CRP(r =0.331 ,P<0.01 ) and UA (r=0. 254,P <0. 05). Conclusions Increased level of hs-CRP and UA is

  14. Association of non-alcoholic fatty liver disease and urinary albumin excretion rate in patients with type 2 dibetes mellitus%2型糖尿病患者非酒精性脂肪肝与尿白蛋白排泄率的关系

    Institute of Scientific and Technical Information of China (English)

    张育仁; 吴静; 李春燕

    2012-01-01

    Objective To investigate the relationship between urinary albumin excretion rate( UAER )and non-alcoholic fatty liver disease( NAFLD )in patients with type 2 dibetes mellitus( T2DM ). Methods Two hundred twenty eight patients were investigated respectively. The patients were divided into two groups( NAFLD group and non-NAFLD group )by liver ultrasonography and disease history, forty heathy persons who were matched for age and sex were served as control, then their clinical data were collected and compared in order to find the differences of biochemical indicators and UAER. Results NAFLD group had higher levels of body mass index( BMI ), triglyceride ( TG),fast insulin and C peptide level, uric acid, homeostasis model assessment HOMA-IR )than those of without NAFLD( P < 0. 05 ). Results of the Chi-square test showed that the mobility of trace albuminuria and mass albuminuria was higher in NAFLD group than that of without NAFLD( x2 = 23. 905, P = 0. 001 ). Logistic analysis showed that BMI( OR = 4. 66 , P = 0. OOf ), TG( OR = 8. 46, P = 0. 000 )and UAER( OR = 3. 73 , P = 0. 003 )were important risk factors for T2DM complicated with NAFLD. Conclusions NAFLD is closely related with higher BMI, TG and UAER in T2DM patients. The mobility of diabetic nephropath)' is significantly higher in T2DM complicated with NAFLD than that of without NAFLD.%目的 探讨合并非酒精性脂肪肝(NAFLD)的2型糖尿病(T2DM)患者尿白蛋白排泄率(UAER)的变化特点及其相关性.方法 T2DM患者228例,根据是否合并NAFLD分为糖尿病合并NAFLD组(135例)和糖尿病无NAFLD组(93例),另选年龄、性别匹配的40例健康受试者为对照组,比较两组患者体重指数(BMI)、空腹血糖(FPG)、血脂、空腹胰岛素(FINS)、空腹C肽、胰岛素抵抗指数(HOMA-IR)、24h UAER的差异,用卡方检验分析两组间正常、微量和大量UAER的分布差异,进一步以T2DM合并NAFLD为应变量,以各临床生化指标为自变量,用单因素和多因

  15. 2型糖尿病患者腹腔内脏脂肪面积与尿白蛋白排泄率相关性分析%Association of visceral adiposity with urinary albumin excretion in type 2 diabetics

    Institute of Scientific and Technical Information of China (English)

    翟莎; 王战建

    2011-01-01

    目的 观察2型糖尿病患者腹腔内脏脂肪面积(VA)与24 h尿白蛋白排泄率(24 h-UAE)的关系.方法 收集河北医科大学第三医院内分泌科住院的2型糖尿病患者一般临床资料、VA、腹部皮下脂肪面积(SA)、24 h-UAE、血脂、空腹血糖、糖化血红蛋白、胰岛素水平和肿瘤坏死因子(TNF)-α.根据VA的四分位数分为4组:A组(VA<131 cm2);B组(131 cm2≤VA<174 cm2);C组(174 cm2≤VA<218 cm2);D组(VA≥218 cm2).比较4组间24 h-UAE水平和大量蛋白尿患病率,同时分析VA 与对数[lg(24 h-UAE)]的相关强度和线性关系.结果 C和D组的24 h-UAE大于A和B组,随着VA增加,大量蛋白尿患病率增加;VA与lg(24 h-UAE)存在相关(r=0.51);VA每增加100 cm2,lg(24 h-UAE)增加0.26个单位,校正相关因素的影响后VA每增加100 cm2,lg(24 h-UAE)增加0.15个单位.在校正性别、甘油三酯的影响后,C组与A组比较,发生大量蛋白尿的危险上升到2.75倍,D组与A组比较,发生大量蛋白尿的危险上升到3.87倍.结论 VA增加是24 h-UAE增多的危险因素,随着VA的增加,大量蛋白尿患病率增加.%Objective To decipher the association of visceral adiposity (VA) with 24-hour urinary albumin excretion (24 h-UAE) in type 2 diabetics.Methods We collected the clinical data, VA, subcutaneous adiposity (SA), 24 h-UAE, blood lipids, fasting blood glucose, glycosylated hemoglobin, insulin and tumor necrosis factor (TNF)-α of type 2 diabetic inpatients at our hospital. According to the quartile of VA, the subjects were divided into 4 groups. And their profiles were compared with regards to the level of 24 h-UAE and the incidence of heavy proteinuria. And their relative intensities and the linear relationship of VA and lg (24 h-UAE) were analyzed.Results lg (24 h-UAE) of groups C and D was larger than that of groups A and B. With the rising level of VA, the prevalence of heavy proteinuria increased. A moderate correlation existed between VA and lg (24 h-UAE)(r=0

  16. Effect of Spironolactone on 24h Urine Albumin Excretion Rate in Rats with Type 2 Diabetes Mellitus%螺内酯对2型糖尿病大鼠24小时尿白蛋白排泄率的影响

    Institute of Scientific and Technical Information of China (English)

    周香然; 韩刚; 孙侃; 常向云; 李军

    2012-01-01

    [目的]观察螺内酯对2型糖尿病大鼠肾功能的影响.[方法]48只大鼠用高脂高糖饲料喂养2个月后,腹腔注射 30 mg/kg链脲佐菌素制备糖尿病大鼠模型.随机分为糖尿病组 (DM组,n =24)、螺内酯治疗组(R组,n =24),另选同批普通饲养大鼠15只作为正常对照组 (C组,n=15),检测第16周末血清中血糖(FBG)、糖化血红蛋白(HbA1c)、钾(K+)、24 h尿白蛋白排泄率(UAER)、尿素氮(U-BUN)、肌酐(Cr)、甘油三酯(TG).并用He染色的方法观察16周后大鼠肾脏的病理学变化.[结果]第16周的血糖水平DM组和 R组相近,无显著差别( P >0.05),但DM组和 R组的血糖水平均显著高于A组( P <0.01);UAER水平DM组和 R组显著高于C组( P <0.01),且R组UAER水平显著低于DM组( P <0.01).[结论] 螺内酯能通过降低糖尿病大鼠UAER,改善糖尿病大鼠的肾功能从而发挥保护肾脏的作用.%[Objective] To observe the effect of spironolactone on renal function in rats with type 2 diabetes mellitus (T2DM). [Methods]The rat model of T2DM was prepared by intraperitoneal injection of streptozocin(STZ) 30mg/kg after feeding high-sugar and fat diet for 2 months. The rats were assigned to diabetic group(group DM, n =24) and spironolactone treatment groupCgroup R, n =24). Other 15 rats fed with normal diet were selected as normal control group (group C, n =15). Blood glucose(FBG) , glycosylated hemoglobin(HbA1c) , kalium(K+) , 24h urine albumin excretion rate(UAER) , urea nitrogen(U-BUN) , creatinine(Cr) and triglyceride(TG) at the end of 16th week were detected. HE staining was used to observe the pathological change of kidney in rats after 16 weeks. [Results] At the end of 16th week, BG level in group DM was similar to that in group R, and there was no significant difference( P >0. 05). BG level in group DM and group R were significantly higher than that in group C( P <0. 01). UAER level in group DM and group R were significantly higher than that in group C( P

  17. Albumin and multiple sclerosis

    OpenAIRE

    LeVine, Steven M

    2016-01-01

    Leakage of the blood–brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue where it is exposed to an inflammatory milieu and tissue damage, e.g., demyelination. Once in the CNS, albumin can participate in protective mechanisms. For example, due to its high concentration and molecular properties, albumin becomes a target for oxidation and nitration reactions. Furth...

  18. Influence of Passive Smoking on Urine Albumin Excretion in Women Patients with Type 2 Diabetes Mellitus%被动吸烟对女性2型糖尿病患者尿清蛋白排泄率的影响

    Institute of Scientific and Technical Information of China (English)

    潘清蓉; 张伟; 徐援

    2012-01-01

    目的 探讨被动吸烟对不吸烟的女性2型糖尿病患者尿清蛋白排泄率(UAE)的影响.方法 对2009年6月-2011年4月在我院住院的521例不吸烟的女性2型糖尿病患者进行被动吸烟的调查,比较被动吸烟暴露者和非被动吸烟暴露者的基本资料、胰岛功能、血脂水平、炎症标志物[C反应蛋白(CRP)、纤维蛋白原、白细胞计数]和8 h UAE.被动吸烟暴露的定义是与吸烟的家人或同事接触至少5年.结果 不吸烟的女性2型糖尿病患者中,294例(56.4%)为被动吸烟暴露者(暴露组),227例(43.6%)为非被动吸烟暴露者(非暴露组).暴露组患者受教育年限显著短于非暴露组,差异有统计学意义(P<0.05),血CRP、纤维蛋白原水平和8 h UAE均显著高于非暴露组,差异有统计学意义(P<0.05),而血高密度脂蛋白胆固醇(HDL-C)水平则显著低于非暴露组,差异有统计学意义(P<0.05).多元逐步回归分析显示,糖尿病病程、收缩压、CRP、胰岛素抵抗指数(HOMA-IR)和被动吸烟累积量是不吸烟的女性2型糖尿病患者8 h UAE的独立影响因子.结论 被动吸烟会增加女性2型糖尿病患者的UAE、血CRP及纤维蛋白原水平,并加重血脂代谢紊乱.%Objective To investigate the influence of passive smoking on urine albumin excretion ( UAE ) in non -smoking women patients with type 2 diabetes mellitus ( T2DM ). Methods Survey of passive smoking was conducted in 521 non - smoking women patients with T2DM hospitalized in our department from June 2009 to April 2011. Basic information, pancreatic function, blood lipid, inflammation marker ( CRP, fibrinogen and leukocyte count ) and 8 h UAE were compared between passive smoking exposure group and passive smoking non — exposure group. Passive smoking was defined as exposure to smoking family members or colleagues for at least five years. Results Among the non - smoking women patients with T2DM, 294 cases ( 56. 4% ) were exposed to passive

  19. The Norwegian Twin Registry.

    Science.gov (United States)

    Nilsen, Thomas S; Brandt, Ingunn; Magnus, Per; Harris, Jennifer R

    2012-12-01

    Norway has a long-standing tradition in twin research, but the data collected in several population-based twin studies were not coordinated centrally or easily accessible to the scientific community. In 2009, the Norwegian Twin Registry was established at the Norwegian Institute of Public Health (NIPH) in Oslo with the purpose of creating a single research resource for Norwegian twin data. As of today, the Norwegian Twin Registry contains 47,989 twins covering birth years 1895-1960 and 1967-1979; 31,440 of these twins consented to participate in health-related research. In addition, DNA from approximately 4,800 of the twins is banked at the NIPH biobank and new studies are continually adding new data to the registry. The value of the Norwegian twin data is greatly enhanced by the linkage opportunities offered by Norway's many nationwide registries, spanning a broad array of medical, demographic, and socioeconomic information.

  20. Preparing for Twins

    Science.gov (United States)

    ... or fraternal, all twins have their individual personalities, styles, and temperament. Both identical and fraternal twins may ... motor skills while the other perfects social or communication abilities. Because they spend so much time together, ...

  1. Monochorionic twin pregnancies

    NARCIS (Netherlands)

    Hack, K.E.A.

    2008-01-01

    Following widespread application of assisted reproductive technology modalities and the increased age of motherhood, the incidence of twin gestations has increased markedly. Twins are either monozygotic or dizygotic. Dizygotic (i.e. fraternal) twins result from the fertilization of two different egg

  2. Albumin-mediated delivery of siRNA

    DEFF Research Database (Denmark)

    Bienk, Konrad

    2015-01-01

    been used to create a range of albumin variants with FcRn affinity both lower and higher than that of wild-type albumin. The aim of this project is to develop a siRNA carrier system utilizing albumin as a natural delivery vehicle. Cholesteryl functionalized siRNA was designed to facilitate binding...... vehicle. This proof of concept silencing showed that siRNA can be used for therapeutic purposes without the use of non-biocompatible polymer or lipid materials. This work, therefore, provides a novel technology platform for the safe delivery of siRNA therapeutics....... in autoimmune disorders, neurodegenerative disorders and cancer by specific gene silencing. The effective delivery of the therapeutic to target cells and tissues is currently a great challenge for successful siRNA therapy. In the bloodstream, free siRNA is rapidly cleared by renal excretion or degraded by serum...

  3. Increased transcapillary escape rate of albumin in type 1 (insulin-dependent) diabetic patients with microalbuminuria

    DEFF Research Database (Denmark)

    Feldt-Rasmussen, B

    1986-01-01

    The transcapillary escape rate, intravascular mass and outflux of albumin were measured in 75 Type 1 (insulin-dependent) diabetic patients. The groups were defined as: group 1: normal urinary albumin excretion, less than 30 mg/24 h (n = 21); group 2: microalbuminuria, 30-300 mg/24 h (n = 36); group...... 3: diabetic nephropathy, less than 300 mg/24 h (n = 18). Fifteen sex- and age-matched non-diabetic persons served as control subjects. The diabetes duration was: group 1: 20 +/- 9 years, group 2: 17 +/- 5 years, group 3: 19 +/- 7 years. The transcapillary escape rate of albumin was similar...

  4. Twin-to-Twin Transfusion Syndrome

    OpenAIRE

    Muhammad Rusda; R. Haryono Roeshadi

    2009-01-01

    Twin-to-twin transfusion syndrome (TTTS), umumnya terjadi pada kehamilan kembar monochorion (MC), dimana terjadi donasi darah secara terus menerus dari satu janin ke janin yang lainnya (satu janin bertindak sebagai donor sedangkan janin yang lainnya bertindak sebagai resipien).Kehamilan kembar monokhorion sangat beresiko untuk mendapat berbagai jenis komplikasi, diantaranya: TTTS, pertumbuhan janin terhambat, kematian janin dan persalinan prematur. Mayoritas dari beberapa kompl...

  5. Copiea - excretion rates of salamaders

    Data.gov (United States)

    U.S. Environmental Protection Agency — Stoichiometry of excreta and excretion rates of a stream-dwelling plethodontid salamander in Cincinnati, OH, USA This dataset is associated with the following...

  6. Acidosis and Urinary Calcium Excretion

    DEFF Research Database (Denmark)

    Alexander, R Todd; Cordat, Emmanuelle; Chambrey, Régine;

    2016-01-01

    Metabolic acidosis is associated with increased urinary calcium excretion and related sequelae, including nephrocalcinosis and nephrolithiasis. The increased urinary calcium excretion induced by metabolic acidosis predominantly results from increased mobilization of calcium out of bone...... and inhibition of calcium transport processes within the renal tubule. The mechanisms whereby acid alters the integrity and stability of bone have been examined extensively in the published literature. Here, after briefly reviewing this literature, we consider the effects of acid on calcium transport...

  7. Malaysian Twin Registry.

    Science.gov (United States)

    Jahanfar, Shayesteh; Jaffar, Sharifah Halimah

    2013-02-01

    The National Malaysian Twin Registry was established in Royal College of Medicine, Perak, University Kuala Lumpur (UniKL) in June 2008 through a grant provided by UniKL. The general objective is to facilitate scientific research involving participation of twins and their family members in order to answer questions of health and wellbeing relevant to Malaysians. Recruitment is done via mass media, poster, and pamphlets. We now have 266 adult and 204 children twins registered. Several research projects including reproductive health study of twins and the role of co-bedding on growth and development of children are carried out. Registry holds annual activities for twins and seeks to provide health-related information for twins. We seek international collaboration.

  8. Perinatal hepatic infarction in twin-twin transfusion.

    LENUS (Irish Health Repository)

    O'Sullivan, M J

    2012-02-03

    We report a case of a twin pregnancy which was complicated by a twin-twin transfusion in which the recipient twin was noted to have an intra-abdominal echogenic mass. This twin died at two days of age of hepatic infarction. The donor twin was healthy at birth, at thirty weeks\\' gestation, and did not have any subsequent problems. Fetal intra-abdominal echogenicity may be a marker of hepatic infarction.

  9. Delivery in Twin Gestation

    Directory of Open Access Journals (Sweden)

    Mark T. Peters

    1995-01-01

    Full Text Available Objective: The objective of this study was to determine whether prophylactic treatment with oral broad-spectrum antimicrobial therapy improves pregnancy outcomes in twin gestations.

  10. Twin anemia polycythemia sequence

    NARCIS (Netherlands)

    Slaghekke, Femke

    2014-01-01

    In this thesis we describe that Twin Anemia Polycythemia Sequence (TAPS) is a form of chronic feto-fetal transfusion in monochorionic (identical) twins based on a small amount of blood transfusion through very small anastomoses. For the antenatal diagnosis of TAPS, Middle Cerebral Artery – Peak Syst

  11. Pre-symptomatic increase in urine-orosomucoid excretion in pre-eclamptic women

    DEFF Research Database (Denmark)

    Kronborg, Camilla S; Allen, Jim; Vittinghus, Erik;

    2007-01-01

    BACKGROUND: Although the pre-eclamptic pathogenesis begins at least around the 18th week of pregnancy, clinically evident disease often does not appear until the third trimester. This long pre-symptomatic latency period has led to intensive research for early markers of evolving disease. We......, 32 women developed pre-eclampsia, and 5 controls for every case of pre-eclampsia were found. Blood samples were collected 4 times and urine samples 6 times from the 18/19th week and throughout pregnancy. Orosomucoid and albumin in plasma were analysed by standard methods, and in urine by sandwich...... excretion can probably be used as a prognostic tool in combination with other screening methods, and seems to be a more sensitive marker for evolving pre-eclampsia than albumin. Plasma orosomucoid is significantly increased late in pre-eclampsia. Thus, the increased excretion of orosomucoid must primarily...

  12. Measurement of the modification and interference rate of urinary albumin detected by size-exclusion HPLC

    International Nuclear Information System (INIS)

    The measurement of the excretion of urinary albumin (albuminuria) is an important and well-established method to assess clinical outcomes. A high-performance liquid chromatography (HPLC) method has been introduced to measure albuminuria. Using this method, it was found that commonly used immunological methods do not measure a fraction of urinary albumin. Some authors presumed that the reason of immuno-unreactivity is the modification of urinary albumin; some others presumed that the difference is merely because of interference. In order to decide this question, we established an HPLC method equipped with tandem UV and fluorescent detection to assess the changes in the detectability of albumin with the rate of modification. For this measurement, differently modified forms of albumin were used. Urine samples of diabetic patients were also measured to find a potential connection between the modification rate and clinical parameters. Secondly, we have established a reversed phase HPLC method to assess the interference rate. We conclude that albumin modification does not affect immunoreactivity. The modification rate of urinary albumin in diabetic patients showed a correlation with renal function. The interference rate of the albumin peak was found to be 12.7% on average, which does not explain the difference between the two methods

  13. Albumin binding ligands and albumin conjugate uptake by cancer cells

    Directory of Open Access Journals (Sweden)

    Frei Eva

    2011-06-01

    Full Text Available Abstract The scope of this short review is to summarise the knowledge gleaned from the fate of drugs transported by albumin upon contact with the target cancer cell or cells in inflamed tissues. The authors expertise covers covalently bound drugs and their cellular uptake and release from albumin. This review therefore aims to deduce what will happen to drugs such as insulin detemir which is considered to bind non-covalently to albumin and may have a fate similar to fatty acids transported by albumin.

  14. Insights on Solar Twins

    Science.gov (United States)

    Sousa Duarte, Tharcisyo Sa e.; Soares da Costa, Jefferson; Dias do Nascimento Júnior, José

    2015-08-01

    The question about how to define a real solar twin are still active. Cayrel de Strobe et al. (1981) defined a solar twin like a star having at the same time the physical parameters, Teff, gravity, bolometric magnitude, microturbulent velocity, and chemical composition. We presented the more extensive sample of solar twins known to date. From these targets we will study the behavior of the solar twins as a function of fundamentals stellar parameters, effective temperature, luminosity, age, convective envelope mass deepening (1 - M*/M⊙), lithium abundance and rotation period. We selected the solar twins from observations with the spectropolarimeters ESPaDOnS at CFHT and the Narval at TBL and also on literature. All objects have high resolution and high signal to noise. Analyze this sample of solar twins will help us to understand how these stars whether located around of the Sun's place. Our preliminary results show that the lithium abundance presents one clear correlation with stellar age. The (1 - M*/M⊙) values obtained through our method provided good agreement with the solar value. The rotation periods allow us to assess the solar twins as a function of gyrochronology.

  15. Effects of beraprost sodium on serum levels of soluble adhesion molecule-1 and C-reactive protein and urinary albumin excretion rate in patients with early diabetic nephropathy%贝前列素钠对早期糖尿病肾病患者血清可溶性细胞间黏附分子1、C反应蛋白及尿微量白蛋白排泄率影响的临床观察

    Institute of Scientific and Technical Information of China (English)

    黄娟; 张韶英; 段晓宇; 管斯斯

    2013-01-01

    Objective To observe the clinical efficacy of beraprost sodium on early stage of diabetic nephropathy(DN).Methods We measured serum levels of serum soluble intercelluhar adhesion molecule (sICAM)-1 in 27 cases with diabetes without nephropathy and 48 cases with early DN.Patients with early DN were randomly assigned into two treatment groups:the conventional treatment group and the beraprost sodium treatment group.Changes of sICAM-1 and C-reactive protein (CRP) levels and urinary albumin excretion rate (UAER) were measured in the two groups before and after treatment.Results The serum sICAM-1 levels in early DN patients was significantly higher than that of the diabetes without nephropathy group((1385 ± 171) g/ Lvs.(943 ± 167) g/L;t =1.034,P =0.002).There were no significant difference observed on levels of sICAM-1,CRP and UAER between the two treatment groups (P > 0.05).The level of sICAM-1 and CRP in the beraprost sodium treatment group was significantly lower than those before treatment (P < 0.05 or P < 0.01).The symptoms were significantly alleviated in both groups (P < 0.05 or P < 0.01),especially for the beraprost sodium treatment group(P < 0.05 or P < 0.01).Conclusion Patients with early DN have elevated serum sICAM-1 levels.Treatment of beraprost sodium has protective effect on early DN as it significantly decreases the serum levels of sICAM-1 and CRP in patients with early DN.%目的 观察贝前列素钠对早期糖尿病肾病(DN)患者的临床疗效.方法 测定27例糖尿病无肾病患者(糖尿病无肾病组)、48例早期DN(DN组)患者血清可溶性细胞间黏附分子1(sICAM-1)浓度,并将48例早期DN患者随机分为两组,常规治疗组和贝前列素钠治疗组,各24例,测定两组治疗前后sICAM-1、C反应蛋白(CRP)及尿微量白蛋白排泄率(UAER)的变化.结果 早期DN患者血清sICAM-1浓度[(1385±171) g/L与(943±167) g/L;t=1.034,P=0.002]明显高于糖尿病无肾病组.贝前列素钠治疗组与

  16. Dogs Discriminate Identical Twins

    Science.gov (United States)

    Pinc, Ludvík; Bartoš, Luděk; Reslová, Alice; Kotrba, Radim

    2011-01-01

    Earlier studies have shown variation among experimental attempts to establish whether human monozygotic twins that are genetically identical also have identical individual scents. In none of the cases were the dogs able to distinguish all the individual scents of monozygotic twins living in the same environment if the scents were presented to them separately. Ten specially trained police German Shepherd dogs of three Czech Republic Police Regional Headquarters were used for scent identification in our study. The dogs were supposed to match scents of two monozygotic pairs (5 and 7 years old) and two dizygotic twin pairs (8 and 13 years old). Scents were collected on cotton squares stored in glass jars. Dog handlers were blind to the experiment details. In each trial (line-up), one scent was used as a starting scent and the dog was then sent to determine if any of the 7 presented glass jars contained a matching scent. Scents of children of similar ages were used as distractors. In the matching procedure, the dogs matched correctly the scent of one twin with the other, as well as two scents collected from every single identical and non-identical twin to prove their efficacy and likewise, the presence of the matching twin scent in any given glass jar. All dogs in all trials distinguished correctly the scents of identical as well as non-identical twins. All dogs similarly matched positively two scents collected from the same individuals. Our findings indicated that specially trained German Shepherd dogs are able to distinguish individual scents of identical twins despite the fact that they live in the same environment, eat the same food and even if the scents are not presented to them simultaneously. PMID:21698282

  17. Dialysis for twins

    OpenAIRE

    Gramkow, Ann-Maria; Aarup, Michael; Andersen, Lise Lotte Torvin; Tepel, Martin

    2014-01-01

    A 32-year-old woman with known stage-4 chronic kidney disease due to lupus nephritis presented with twin pregnancy after in vitro fertilization at a gestational age of 24 weeks + 3 days because of imminent preterm labour. Repeated ultrasound evaluations confirmed intrauterine growth restriction in both twins and polyhydramnios as the cause of imminent preterm labour. After initiation of haemodialysis treatment, ultrasound evaluation showed a significant decrease in amniotic fluids, and also r...

  18. Specific complications of monochorionic twin pregnancies: twin-twin transfusion syndrome and twin reversed arterial perfusion sequence.

    Science.gov (United States)

    Chalouhi, G E; Stirnemann, J J; Salomon, L J; Essaoui, M; Quibel, T; Ville, Y

    2010-12-01

    Monochorionic twins are subjected to specific complications which originate in either imbalance or abnormality of the single placenta serving two twins. This unequal placental sharing can cause complications including twin-twin transfusion syndrome (TTTS), twin anemia-polycythemia sequence (TAPS), selective intrauterine growth restriction or twin reversed arterial perfusion sequence (TRAP). Monochorionicity also makes the management of these specific complications as well as that of a severe malformation in one twin hazardous since the spontaneous death of one twin exposes the co-twin to a risk of exsanguination into the dead twin and its placenta. The latter is responsible for the death of the co-twin in up to 20% of the cases and in ischemic sequelae in about the same proportions in the survivors. Although the symptoms of all these complications are very different, the keystone of their management comes down to either surgical destruction of the inter-twin anastomoses on the chorionic plate when aiming at dual survival or selective and permanent occlusion of the cord of a severely affected twin aiming at protecting the normal co-twin. This can be best achieved by fetoscopic selective laser coagulation and bipolar forceps cord coagulation respectively. PMID:20855238

  19. Predicting nitrogen excretion from cattle.

    Science.gov (United States)

    Reed, K F; Moraes, L E; Casper, D P; Kebreab, E

    2015-05-01

    Manure nitrogen (N) from cattle production facilities can lead to negative environmental effects, such as contribution to greenhouse gas emissions, leaching and runoff to aqueous ecosystems leading to eutrophication, and acid rain. To mitigate these effects and to improve the efficiency of N use, accurate prediction of N excretion and secretions are required. A genetic algorithm was implemented to select models to predict fecal, urinary, and total manure N excretions, and milk N secretions from 3 classes of animals: lactating dairy cows, heifers and dry cows, and steers. Two tiers of model classes were developed for each category of animals based on model input requirements. A total of 6 models for heifers and dry cows and steers and an additional 2 models for lactating dairy cattle were developed. Evaluation of the models using K-fold cross validation based on all data and using the most recent 6 yr of data showed better prediction for total manure N and fecal N compared with urinary N excretion, which was the most variable response in the database. Compared with extant models from the literature, the models developed in this study resulted in a significant improvement in prediction error for fecal and urinary N excretions from lactating cows. For total manure production by lactating cows, extant and new models were comparable in their prediction ability. Both proposed and extant models performed better than the prediction methods used by the US Environmental Protection Agency for the national inventory of greenhouse gases. Therefore, the proposed models are recommended for use in estimation of manure N from various classes of animals. PMID:25747829

  20. Disorders of absorption of olive oil and albumin labelled with iodine 125 in rats receiving tetracycline

    International Nuclear Information System (INIS)

    The influence of tetracycline on absorption and distribution of olive oil and albumin labelled with iodine 125 was studied in the intestines, liver, blood and kidneys. In rats which received tetracycline in therapeutic doses no detectable changes in absorption and distribution of labelled olive oil were noticed. In rats which received the double doses, disorders of absorption and distribution were observed in the small intestine and increased retention in the liver. The higher doses of tetracycline had no significant effect on absorption of labelled albumin, but transport and excretion were disturbed. (author)

  1. Albumin binding ligands and albumin conjugate uptake by cancer cells

    OpenAIRE

    Frei Eva

    2011-01-01

    Abstract The scope of this short review is to summarise the knowledge gleaned from the fate of drugs transported by albumin upon contact with the target cancer cell or cells in inflamed tissues. The authors expertise covers covalently bound drugs and their cellular uptake and release from albumin. This review therefore aims to deduce what will happen to drugs such as insulin detemir which is considered to bind non-covalently to albumin and may have a fate similar to fatty acids transported by...

  2. Albuminuria and overall capillary permeability of albumin in acute altitude hypoxia

    DEFF Research Database (Denmark)

    Hansen, J M; Olsen, Niels Vidiendal; Feldt-Rasmussen, B;

    1994-01-01

    The mechanism of proteinuria at high altitude is unclear. Renal function and urinary excretion rate of albumin (Ualb) at rest and during submaximal exercise and transcapillary escape rate of 125I-labeled albumin (TERalb) were investigated in 12 normal volunteers at sea level and after rapid...... groups. Exercise did not reveal any further renal dysfunction. In both groups, high altitude increased TERalb from 4.8 to > 6.7%/h (P function and independent of effects of isradipine on filtration fraction...... and passive ascent to 4,350 m. The calcium antagonist isradipine (5 mg/day; n = 6) or placebo (n = 6) was administered to abolish hypoxia-induced rises in blood pressure. Lithium clearance and urinary excretion of beta 2-microglobulin were used to evaluate renal tubular function. High altitude increased Ualb...

  3. Albuminuria and overall capillary permeability of albumin in acute altitude hypoxia

    DEFF Research Database (Denmark)

    Hansen, J M; Olsen, N V; Feldt-Rasmussen, B;

    1994-01-01

    groups. Exercise did not reveal any further renal dysfunction. In both groups, high altitude increased TERalb from 4.8 to > 6.7%/h (P < 0.05). In conclusion, acute altitude hypoxia increases Ualb despite unchanged tubular function and independent of effects of isradipine on filtration fraction. The......The mechanism of proteinuria at high altitude is unclear. Renal function and urinary excretion rate of albumin (Ualb) at rest and during submaximal exercise and transcapillary escape rate of 125I-labeled albumin (TERalb) were investigated in 12 normal volunteers at sea level and after rapid and...... passive ascent to 4,350 m. The calcium antagonist isradipine (5 mg/day; n = 6) or placebo (n = 6) was administered to abolish hypoxia-induced rises in blood pressure. Lithium clearance and urinary excretion of beta 2-microglobulin were used to evaluate renal tubular function. High altitude increased Ualb...

  4. Relativistic twins or sextuplets?

    CERN Document Server

    Sheldon, E S

    2003-01-01

    A recent study of the relativistic twin 'paradox' by Soni in this journal affirmed that 'A simple solution of the twin paradox also shows anomalous behaviour of rigidly connected distant clocks' but entailed a pedagogic hurdle which the present treatment aims to surmount. Two scenarios are presented: the first 'flight-plan' is akin to that depicted by Soni, with constant-velocity segments, while the second portrays an alternative mission undertaken with sustained acceleration and deceleration, illustrated quantitatively for a two-way spacecraft flight from Earth to Polaris (465.9 light years distant) and back.

  5. Imaging of conjoined twins

    Energy Technology Data Exchange (ETDEWEB)

    McHugh, Kieran [Great Ormond Street Hospital for Children, Department of Radiology, London (United Kingdom); Kiely, Edward M.; Spitz, Lewis [Great Ormond Street Hospital for Children, Department of Surgery, London (United Kingdom)

    2006-09-15

    The incidence of conjoined twins is estimated to be around 1 in 250,000 live births. There is a distinct female predominance. In this paper the imaging of conjoined twins both antenatally and postnatally is reviewed, in particular taking into consideration recent advances with multidetector CT. Accurate counselling of parents regarding the likely outcome of the pregnancy and the likelihood of successful separation is dependent on good prenatal imaging with ultrasound and MRI. Planning of postnatal surgical separation is aided by accurate preoperative imaging which, depending on the conjoined area, will encompass many imaging modalities, but often relies heavily on CT scanning. (orig.)

  6. 21 CFR 640.80 - Albumin (Human).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Albumin (Human). 640.80 Section 640.80 Food and... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Albumin (Human) § 640.80 Albumin (Human). (a) Proper name and definition. The proper name of the product shall be Albumin (Human). The product is defined...

  7. Reflections on twin relationships: twins reared apart and twins of opposite gender.

    Science.gov (United States)

    Segal, Nancy L

    2012-12-01

    The complexities of twin relationships posed by separate rearing and by opposite sex are considered. Unusual cases may highlight unique social-interactional processes and outcomes occurring in these pairs. Research reviews include recent twin studies on second language acquisition, political behavior, and multiple birth rates. Items of more general interest include twin 'cousins' reared apart, indistinguishable monozygotic quadruplets, a genetic testing dilemma, and a performance about separated twins. PMID:23363461

  8. Dialysis for twins

    DEFF Research Database (Denmark)

    Gramkow, Ann-Maria; Aarup, Michael; Andersen, L. L. T.;

    2014-01-01

    A 32-year-old woman with known stage-4 chronic kidney disease due to lupus nephritis presented with twin pregnancy after in vitro fertilization at a gestational age of 24 weeks + 3 days because of imminent preterm labour. Repeated ultrasound evaluations confirmed intrauterine growth restriction...

  9. Amelia in Twin Pregnancy

    Directory of Open Access Journals (Sweden)

    Davari Tanha Fatemeh

    2009-04-01

    Full Text Available Limb bud first appears during the third week of gestation with the upper limb buds appearing a few days before the lower limb buds. Complete absence of one or more limbs, called Amelia, occurs prior to the eighth week of gestation. We report a case of Amelia in a twin gestation.

  10. Enhancement of radiopharmaceutical excretion by chemical interventions

    International Nuclear Information System (INIS)

    It was shown previously that desferrioxamine (DFO) enhances urinary excretion of Ga-67. The present study is an extension of these observations to other compounds that may enhance the excretion of Tc-99m pertechnetate (Tc), Ga-67 citrate (Ga) and Tl-201 chloride (Tl). The purpose of these studies was to find methods of decreasing the radiation dose after radionuclide studies, by giving a compound that will increase the rate of excretion of the radionuclide

  11. Twin-twin transfusion syndrome - diagnosis and prognosis

    Directory of Open Access Journals (Sweden)

    Hajrić-Egić Amira

    2003-01-01

    Full Text Available Twin-twin transfusion syndrome is a serious complication of monozygotic, monochorionic, diamniotic twins resulting from transplacental vascular communications. In this syndrome blood is thought to be shunted from one twin - donor,who develops anaemia,growth retardation and oligoamnios, to the other twin - recipient,who becomes plethoric,macrosomic and develops polyhydroamnios. The incidence of twin-twin transfusion syndrome ranges from 5-15% of all twin pregnancies. If this condition develops in the second trimester, it is usually associated with spontaneous abortion and death of one or both fetuses before viability. Developing the syndrome in the third trimester has better perinatal outcome. Mortality rates ranging from 56%-100%, depending on gestational age and severity of the syndrome. The ultrasound criterias for diagnosis, in this study,were the presence of twins of the same sex with discordant growth, with oligohydroamnios in one twin sac and polyhydroamnios in the other one, one placenta and thin membrane between twins. The present study shows clinical course of 14 cases and value of Doppler ultrasound to analyze the usefulness of umbilical artery blood flow velocimetry for predicting the risk of twin-twin transfusion syndrome. 14 twin pregnancies with twin-twin transfusion syndrome were diagnosed during the last four years period and prospectivelly followed. 9 cases were diagnosed before the completion od 28 weeks of gestation.The mean gestational age was 21,6_+4,2 weeks at diagnosis and 23,2+_3,6 weeks at delivery. 5 cases were diagnosed after 28 weeks of gestation. The mean gestational age in this group was 29,6+_2,1 weeks at diagnosis and 33+_3,3 weeks at delivery. The survival rate in this study was 29%(8/28.9 cases ended in spontaneous abortion between 18th and 27th weeks of pregnancy (table 1 and 5 in premature labor (table 2.There were 7 intrauterine death (5 at admission and 2 few days after admission and 13 neonatal deaths

  12. Brazilian Twin Registry: A Bright Future for Twin Studies/Twin Research: Twin Study of Alcohol Consumption and Mortality; Oxygen Uptake in Adolescent Twins/In the News: Superfecundated Twins In Vietnam; Adolescent Twin Relations; Twin and Triplet Co-Workers; A Special Twin Ultrasound; Monozygotic Twins With Different Skin Color; Identical Twin Returns from Space.

    Science.gov (United States)

    Segal, Nancy L

    2016-06-01

    The establishment of the Brazilian Twin Registry for the study of genetic, social, and cultural influences on behavior is one of eleven newly funded projects in the Department of Psychology at the University of São Paulo. These 11 interrelated projects form the core of the university's Center for Applied Research on Well-Being and Human Behavior. An overview of the planned twin research and activities to date is presented. Next, two recent twin studies are reviewed, one on the relationship between alcohol consumption and mortality, and the other on factors affecting maximal oxygen uptake. Twins cited in the media include the first identified superfecundated twins in Vietnam, adolescent twin relations, twins and triplets who work together, monozygotic twins with different skin tones and a co-twin control study that addresses the effects of space travel. PMID:27121223

  13. Brazilian Twin Registry: A Bright Future for Twin Studies/Twin Research: Twin Study of Alcohol Consumption and Mortality; Oxygen Uptake in Adolescent Twins/In the News: Superfecundated Twins In Vietnam; Adolescent Twin Relations; Twin and Triplet Co-Workers; A Special Twin Ultrasound; Monozygotic Twins With Different Skin Color; Identical Twin Returns from Space.

    Science.gov (United States)

    Segal, Nancy L

    2016-06-01

    The establishment of the Brazilian Twin Registry for the study of genetic, social, and cultural influences on behavior is one of eleven newly funded projects in the Department of Psychology at the University of São Paulo. These 11 interrelated projects form the core of the university's Center for Applied Research on Well-Being and Human Behavior. An overview of the planned twin research and activities to date is presented. Next, two recent twin studies are reviewed, one on the relationship between alcohol consumption and mortality, and the other on factors affecting maximal oxygen uptake. Twins cited in the media include the first identified superfecundated twins in Vietnam, adolescent twin relations, twins and triplets who work together, monozygotic twins with different skin tones and a co-twin control study that addresses the effects of space travel.

  14. Synergism between maggot excretions and antibiotics.

    Science.gov (United States)

    Cazander, Gwendolyn; Pawiroredjo, Janity S; Vandenbroucke-Grauls, Christina M J E; Schreurs, Marco W J; Jukema, Gerrolt N

    2010-01-01

    Maggots are successfully used to treat severe, infected wounds. This study investigated whether maggot excretions/secretions influence the antibacterial activity of different antibiotics. Minimal inhibitory concentrations and minimal bactericidal concentrations (MBC) were determined of gentamicin and flucloxacillin for Staphylococcus aureus, of penicillin for Streptococcus pyogenes, of amoxicillin and vancomycin for Enterococcus faecalis, of gentamicin for Enterobacter cloacae, and of gentamicin, tobramycin, and ciprofloxacin for Pseudomonas aeruginosa by checkerboard titration. A range of concentrations of antibiotics in combination with excretions/secretions was examined to investigate the potential of maggot excretions/secretions to affect antibacterial activity. The results showed a dose-dependent increase of the antibacterial effect of gentamicin in the presence of excretions/secretions on S. aureus. Minimal concentrations and MBC of gentamicin decreased, respectively, 64- and 32-fold. The MBC of flucloxacillin and excretions/secretions against S. aureus were also decreased. The other antibiotic and excretions/secretions combinations exerted an indifferent effect. Excretions/secretions alone did not have any antibacterial effect. The synergism between gentamicin and maggot excretions/secretions could be of direct importance in clinical practice, because it could allow the use of lower doses of gentamicin and thus minimize the risk of gentamicin-related side effects.

  15. Minimal Mirror Twin Higgs

    CERN Document Server

    Barbieri, Riccardo; Harigaya, Keisuke

    2016-01-01

    In a Mirror Twin World with a maximally symmetric Higgs sector the little hierarchy of the Standard Model can be significantly mitigated, perhaps displacing the cutoff scale above the LHC reach. We show that consistency with observations requires that the Z2 parity exchanging the Standard Model with its mirror be broken in the Yukawa couplings. A minimal such effective field theory, with this sole Z2 breaking, can generate the Z2 breaking in the Higgs sector necessary for the Twin Higgs mechanism, and has constrained and correlated signals in invisible Higgs decays, direct Dark Matter Detection and Dark Radiation, all within reach of foreseen experiments. For dark matter, both mirror neutrons and a variety of self-interacting mirror atoms are considered. Neutrino mass signals and the effects of a possible additional Z2 breaking from the vacuum expectation values of B-L breaking fields are also discussed.

  16. Albumin-based drug delivery

    DEFF Research Database (Denmark)

    Larsen, Maja Thim; Kuhlmann, Matthias; Hvam, Michael Lykke;

    2016-01-01

    The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand...... binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent...... conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform....

  17. Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes

    DEFF Research Database (Denmark)

    Sandholm, Niina; Forsblom, Carol; Mäkinen, Ville-Petteri;

    2014-01-01

    gene were strongly associated with albuminuria (p < 5 × 10(-8)). In the replication group, a nominally significant association (p = 0.035) was observed between albuminuria and rs1564939 in GLRA3, but this was in the opposite direction. Sequencing of the surrounding genetic region in 48 Finnish and 48...... killer cell mediated immunity processes. CONCLUSIONS/INTERPRETATION: This study suggests novel pathways and molecular mechanisms for the pathogenesis of albuminuria in type 1 diabetes....

  18. Effect of candesartan on microalbuminuria and albumin excretion rate in diabetes: three randomized trials

    DEFF Research Database (Denmark)

    Bilous, Rudy; Chaturvedi, Nish; Sjølie, Anne Katrin;

    2009-01-01

    BACKGROUND: Microalbuminuria in diabetes is strongly predictive of nephropathy, end-stage renal disease, and premature cardiovascular morbidity and mortality. Effective preventive therapies are therefore a clinical priority. OBJECTIVE: To determine whether the angiotensin-receptor blocker candesa...

  19. Is it time to change the definition of normal urinary albumin excretion?

    DEFF Research Database (Denmark)

    Wachtell, K.; Olsen, M.H.

    2008-01-01

    intensive follow-up. In addition, although previous studies have indicated that cardiovascular risk increases exponentially with increasing levels of albuminuria, the definition of the threshold for albuminuria should be dependent on concomitant cardiovascular disease (i.e. lower levels of albuminuria...... at baseline and had normoalbuminuria by conventional definitions. The study showed that quartiles of albuminuria beyond the lowest quartile were increasingly predictive of subsequent hypertensive disease, even at levels well below what is conventionally considered to be the normal range. This commentary...... highlights the importance of evaluating albuminuria as an indicator of target organ damage and a risk factor for cardiovascular disease. Patients without hypertension, diabetes or other cardiovascular diseases who have albuminuria should be considered at risk of cardiovascular disease and should undergo...

  20. Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats

    NARCIS (Netherlands)

    Kim, K.; Warden, C.H.; Griffey, S.M.; Vilches-Moure, J.G.; Hansen, S.; Cuppen, E.; Nijman, I.J.; Chiu, S.; Stern, J.S.

    2010-01-01

    We have previously shown that 90% of outbred obese Zucker Lepr(fa/fa) rats die prematurely of renal disease. Thus, renal disease in obese Zucker Lepr(fa/fa) rats may be caused by the LEPR mutation on chromosome 5, by the obesity, or it may be influenced by Zucker susceptibility alleles of genes on o

  1. Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs

    OpenAIRE

    Roopenian, Derry C.; Low, Benjamin E.; Christianson, Gregory J.; Proetzel, Gabriele; Sproule, Thomas J.; Wiles, Michael V.

    2015-01-01

    Serum albumin is the major determinant of blood colloidal osmotic pressure acting as a depot and distributor of compounds including drugs. In humans, serum albumin exhibits an unusually long half-life mainly due to protection from catabolism by neonatal Fc receptor (FcRn)-mediated recycling. These properties make albumin an attractive courier of therapeutically-active compounds. However, pharmaceutical research and development of albumin-based therapeutics has been hampered by the lack of app...

  2. Socioeconomic position and twins' health

    DEFF Research Database (Denmark)

    Osler, Merete; McGue, Matt; Christensen, Kaare

    2007-01-01

    , physical activity, smoking, alcohol and food intake. RESULTS: The expected associations between the individual twins' adult social class and health measures were observed. Among DZ male twins discordant on adult social class, the higher social class twin was on average significantly taller and had higher...... on adult social class. For most health outcomes, the variability within twin pairs was related to zygosity (higher for DZ than for MZ) but not to social class. CONCLUSION: This study suggests that the relationship between adult social class and health outcomes in Denmark is due mainly to selection effects...... rather than a causal effect of social class exposures on health and behaviour....

  3. Fingerprint Recognition with Identical Twin Fingerprints

    OpenAIRE

    Xunqiang Tao; Xinjian Chen; Xin Yang; Jie Tian

    2012-01-01

    Fingerprint recognition with identical twins is a challenging task due to the closest genetics-based relationship existing in the identical twins. Several pioneers have analyzed the similarity between twins' fingerprints. In this work we continue to investigate the topic of the similarity of identical twin fingerprints. Our study was tested based on a large identical twin fingerprint database that contains 83 twin pairs, 4 fingers per individual and six impressions per finger: 3984 (83*2*4*6)...

  4. Twin Legacies: Victor and Vincent McKusick/Twin Studies: Twinning Rates I; Twinning Rates II; MZ Twin Discordance for Russell-Silver Syndrome; Twins' Language Skills/Headlines: Babies Born to Identical Twin Couples; Identity Exchange; Death of Princess Ashraf (Twin); Yahoo CEO Delivers Identical Twins.

    Science.gov (United States)

    Segal, Nancy L

    2016-04-01

    The lives of the illustrious monozygotic (MZ) twins, Victor A. and Vincent L. McKusick, are described. Victor earned the distinction as the 'Father of Medical Genetics', while Vincent was a legendary Chief Justice of the Maine Supreme Court. This dual biographical account is followed by two timely reports of twinning rates, a study of MZ twin discordance for Russell-Silver Syndrome (RSS) and a study of twins' language skills. Twin stories in the news include babies born to identical twin couples, a case of switched identity, the death of Princess Ashraf (Twin) and a new mother of twins who is also Yahoo's CEO.

  5. Twin Legacies: Victor and Vincent McKusick/Twin Studies: Twinning Rates I; Twinning Rates II; MZ Twin Discordance for Russell-Silver Syndrome; Twins' Language Skills/Headlines: Babies Born to Identical Twin Couples; Identity Exchange; Death of Princess Ashraf (Twin); Yahoo CEO Delivers Identical Twins.

    Science.gov (United States)

    Segal, Nancy L

    2016-04-01

    The lives of the illustrious monozygotic (MZ) twins, Victor A. and Vincent L. McKusick, are described. Victor earned the distinction as the 'Father of Medical Genetics', while Vincent was a legendary Chief Justice of the Maine Supreme Court. This dual biographical account is followed by two timely reports of twinning rates, a study of MZ twin discordance for Russell-Silver Syndrome (RSS) and a study of twins' language skills. Twin stories in the news include babies born to identical twin couples, a case of switched identity, the death of Princess Ashraf (Twin) and a new mother of twins who is also Yahoo's CEO. PMID:26934824

  6. Confronting Twin Paradox Acceleration

    Science.gov (United States)

    Murphy, Thomas W.

    2016-05-01

    The resolution to the classic twin paradox in special relativity rests on the asymmetry of acceleration. Yet most students are not exposed to a satisfactory analysis of what exactly happens during the acceleration phase that results in the nonaccelerated observer's more rapid aging. The simple treatment presented here offers both graphical and quantitative solutions to the problem, leading to the correct result that the acceleration-induced age gap is 2Lβ years when the one-way distance L is expressed in light-years and velocity β ≡v/c .

  7. Holographic twin Higgs model.

    Science.gov (United States)

    Geller, Michael; Telem, Ofri

    2015-05-15

    We present the first realization of a "twin Higgs" model as a holographic composite Higgs model. Uniquely among composite Higgs models, the Higgs potential is protected by a new standard model (SM) singlet elementary "mirror" sector at the sigma model scale f and not by the composite states at m_{KK}, naturally allowing for m_{KK} beyond the LHC reach. As a result, naturalness in our model cannot be constrained by the LHC, but may be probed by precision Higgs measurements at future lepton colliders, and by direct searches for Kaluza-Klein excitations at a 100 TeV collider.

  8. Twin Higgs WIMP Dark Matter

    CERN Document Server

    García, Isabel García; March-Russell, John

    2015-01-01

    Dark matter (DM) without a matter asymmetry is studied in the context of Twin Higgs (TH) theories in which the LHC naturalness problem is addressed. These possess a twin sector related to the Standard Model (SM) by a (broken) $\\mathbb{Z}_2$ symmetry, and interacting with the SM via a specific Higgs portal. We focus on the minimal realisation of the TH mechanism, the Fraternal Twin Higgs, with only a single generation of twin quarks and leptons, and $SU(3)'\\times SU(2)'$ gauge group. We show that a variety of natural twin-WIMP DM candidates are present (directly linked to the weak scale by naturalness), the simplest and most attractive being the $\\tau^\\prime$ lepton with a mass $m_{\\tau^\\prime} > m_{\\rm Higgs}/2$, although spin-1 $W^{\\prime\\pm}$ DM and multicomponent DM are also possible (twin baryons are strongly disfavoured by tuning). We consider in detail the dynamics of the possibly (meta)stable glueballs in the twin sector, the nature of the twin QCD phase transition, and possible new contributions to th...

  9. Transformation: From Twin to Individual

    Science.gov (United States)

    Magagna, Jeanne

    2007-01-01

    This article explores some of the complexities of psychotherapy with an identical twin. The difficulty of developing in psychotherapy while so much of what is oneself is located in the other twin will also be explored. The use of the countertransference as a therapeutic method will be considered as the young person develops her unique, separate…

  10. Iodine excretion in school children in Copenhagen

    DEFF Research Database (Denmark)

    Rasmussen, Lone B; Kirkegaard-Klitbo, Ditte Marie; Laurberg, Peter;

    2016-01-01

    INTRODUCTION: Studies of dietary habits show a high iodine intake in children in Denmark. Iodine excretion in children has not previously been assessed. Iodine excretion in adults is below the recommended threshold, and it is therefore being discussed to increase the fortification level. The main...... objective of this study was to assess iodine excretion in children living in Copenhagen to establish whether a moderate increase in iodine fortification would lead to excess iodine intake in this group. METHODS: Children in first and fifth grade were recruited through schools in Copenhagen. In total, 244...... according to grade. The UIC was higher in children than in adults from the same area. CONCLUSIONS: The iodine excretion among schoolchildren in Copenhagen, an area with a relatively high iodine content in tap water, was within the recommended range as assessed by the UIC. An increased iodine fortification...

  11. Twin methodology in epigenetic studies

    DEFF Research Database (Denmark)

    Tan, Qihua; Christiansen, Lene; von Bornemann Hjelmborg, Jacob;

    2015-01-01

    of diseases to molecular phenotypes in functional genomics especially in epigenetics, a thriving field of research that concerns the environmental regulation of gene expression through DNA methylation, histone modification, microRNA and long non-coding RNA expression, etc. The application of the twin method...... to molecular phenotypes offers new opportunities to study the genetic (nature) and environmental (nurture) contributions to epigenetic regulation of gene activity during developmental, ageing and disease processes. Besides the classical twin model, the case co-twin design using identical twins discordant...... for a trait or disease is becoming a popular and powerful design for epigenome-wide association study in linking environmental exposure to differential epigenetic regulation and to disease status while controlling for individual genetic make-up. It can be expected that novel uses of twin methods in epigenetic...

  12. TWIN REVERSED ARTERIAL PERFUSION SEQUENCE (TRAP SEQUENCE). THE ACARDIAC /ACEPHALIC TWIN

    OpenAIRE

    S. Saritha; Sumedha S. Anjankar

    2013-01-01

    Twin-Reversed Arterial Perfusion (TRAP sequence) is a rare complication of monochorionic twins (MC, twins sharing one placenta). TRAP sequence is known as acardius or chorioangiopagus parasiticus. It occurs in 1% of monochorionic twin pregnancies and in 1 in 35,000 pregnancies. The risk of recurrence was estimated 1:10,000. TRAP sequence is characterized by a structurally normal pump twin perfusing an anomalous twin. In TRAP syndrome, there is mortality and deformities in both twins. ...

  13. A Computational Discriminability Analysis on Twin Fingerprints

    Science.gov (United States)

    Liu, Yu; Srihari, Sargur N.

    Sharing similar genetic traits makes the investigation of twins an important study in forensics and biometrics. Fingerprints are one of the most commonly found types of forensic evidence. The similarity between twins’ prints is critical establish to the reliability of fingerprint identification. We present a quantitative analysis of the discriminability of twin fingerprints on a new data set (227 pairs of identical twins and fraternal twins) recently collected from a twin population using both level 1 and level 2 features. Although the patterns of minutiae among twins are more similar than in the general population, the similarity of fingerprints of twins is significantly different from that between genuine prints of the same finger. Twins fingerprints are discriminable with a 1.5%~1.7% higher EER than non-twins. And identical twins can be distinguished by examine fingerprint with a slightly higher error rate than fraternal twins.

  14. Dramatically different dizygotic twins: will we include them in Research? Twin research reviews: congenital anomalies, mirror-image effects in conjoined twins, older mothers of twins; Twin statistics: 'Massachusetts, land of twins'; Tribute: Dr Victor A. McKusick.

    Science.gov (United States)

    Segal, Nancy L

    2008-10-01

    The increased frequency of interracial marriage is a likely source of unusual-looking dizygotic (DZ) twins. Some members of DZ twin pairs born to mixed-race couples inherit very different physical features from their parents. This raises several questions, such as: Will researchers wish to include such twins in their ongoing studies? Next, new twin research concerned with congenital anomalies, mirror-image effects in conjoined twins and older mothers of twins will be reviewed. New statistics on twinning rates in Massachusetts will also be summarized, followed by a tribute to the late medical geneticist Dr. Victor A. McKusick.

  15. The 2016 Satellite Meeting of the International Society of Twin Studies: An Overview/Tribute to Irving I. Gottesman/Research: MZ Twinning After Single Embryo Transfer; Twin Study of Mononucleosis; Cerebral Injury After Twin-To-Twin Transfusion Syndrome Surgery/Human Interest: Sixteen Twin Pairs Born in a Single Hospital; Death of an Identical Twin Playwright; Twin Themes in Advertising; Conjoined Twins Separated in Saudi Arabia; Murder of One Twin By Her Co-Twin Disproved.

    Science.gov (United States)

    Segal, Nancy L

    2016-10-01

    The 2016 Satellite Meeting of the International Society of Twin Studies took place on June 20 in Brisbane, Australia. The host institution was the QIMR Berghofer Medical Research Institute. An overview of selected presentations and activities is provided. This synopsis is followed by a brief tribute to the recent passing of our esteemed colleague, Dr Irving I. Gottesman. Next, there are summaries of research on monozygotic twinning after single embryo transfer, a twin study of mononucleosis susceptibility, cerebral injury following twin-to-twin transfusion syndrome surgery, and a correction and clarification regarding an article by Segal (2016) on the Brazilian Twin Registry. Human interest articles cover a hospital whose 2015 newborns included 16 pairs of twins born in 1 month, the death of an identical twin playwright, twin themes in advertising, conjoined twins separated in Saudi Arabia, and the dismissed charges of the murder of one twin by her co-twin. PMID:27524469

  16. Urinary adiponectin excretion rises with increasing albuminuria in type 1 diabetes

    DEFF Research Database (Denmark)

    Jorsal, Anders; Petersen, Emilie Hein; Tarnow, Lise;

    2013-01-01

    AIM: Urinary adiponectin (u-adiponectin) excretion has been suggested to reflect early glomerular damage. Inspired by this, we studied the levels of u-adiponectin in type 1 diabetic patients with different levels of urinary albumin excretion (UAE). METHODS: U-adiponectin was analysed by ELISA in...... type 1 diabetic patients: Fifty-eight with normoalbuminuria (<30mg albumin/24h), 43 with persistent microalbuminuria (30-300mg/24h) and 44 with persistent macroalbuminuria (>300mg/24h). For comparison, a control group of 55 healthy individuals was included. RESULTS: U-adiponectin increased with...... increasing levels of UAE (p<0.01). U-adiponectin median (interquartile range): Normoalbuminuria 0.38 (0.14-1.31), microalbuminuria 1.12 (0.20-2.68), macroalbuminuria 9.20 (1.10-23.35) and controls 0.09 (0.06-0.24) μg/g creatinine. Levels were unrelated to sex, age, cholesterol, diastolic BP and BMI. U-adiponectin...

  17. Twin Higgs Asymmetric Dark Matter.

    Science.gov (United States)

    García García, Isabel; Lasenby, Robert; March-Russell, John

    2015-09-18

    We study asymmetric dark matter (ADM) in the context of the minimal (fraternal) twin Higgs solution to the little hierarchy problem, with a twin sector with gauged SU(3)^{'}×SU(2)^{'}, a twin Higgs doublet, and only third-generation twin fermions. Naturalness requires the QCD^{'} scale Λ_{QCD}^{'}≃0.5-20  GeV, and that t^{'} is heavy. We focus on the light b^{'} quark regime, m_{b^{'}}≲Λ_{QCD}^{'}, where QCD^{'} is characterized by a single scale Λ_{QCD}^{'} with no light pions. A twin baryon number asymmetry leads to a successful dark matter (DM) candidate: the spin-3/2 twin baryon, Δ^{'}∼b^{'}b^{'}b^{'}, with a dynamically determined mass (∼5Λ_{QCD}^{'}) in the preferred range for the DM-to-baryon ratio Ω_{DM}/Ω_{baryon}≃5. Gauging the U(1)^{'} group leads to twin atoms (Δ^{'}-τ^{'}[over ¯] bound states) that are successful ADM candidates in significant regions of parameter space, sometimes with observable changes to DM halo properties. Direct detection signatures satisfy current bounds, at times modified by dark form factors.

  18. Twin Higgs Asymmetric Dark Matter

    CERN Document Server

    García, Isabel García; March-Russell, John

    2015-01-01

    We study Asymmetric Dark Matter (ADM) in the context of the minimal (Fraternal) Twin Higgs solution to the little hierarchy problem, with a twin sector with gauged $SU(3)' \\times SU(2)'$, a twin Higgs, and only third generation twin fermions. Naturalness requires the QCD$^\\prime$ scale $\\Lambda'_{\\rm QCD} \\simeq 0.5 - 20 \\ {\\rm GeV}$, and $t'$ to be heavy. We focus on the light $b'$ quark regime, $m_{b'} \\lesssim \\Lambda'_{\\rm QCD}$, where QCD$^\\prime$ is characterised by a single scale $\\Lambda'_{\\rm QCD}$ with no light pions. A twin baryon number asymmetry leads to a successful DM candidate: the spin-3/2 twin baryon, $\\Delta' \\sim b'b'b'$, with a dynamically determined mass ($\\sim 5 \\Lambda'_{\\rm QCD}$) in the preferred range for the DM-to-baryon ratio $\\Omega_{\\rm DM}/\\Omega_{\\rm baryon} \\simeq 5$. Gauging the $U(1)'$ group leads to twin atoms ($\\Delta'$ - $\\bar {\\tau'}$ bound states) that are successful ADM candidates in significant regions of parameter space, sometimes with observable changes to DM halo ...

  19. Twin Higgs Asymmetric Dark Matter.

    Science.gov (United States)

    García García, Isabel; Lasenby, Robert; March-Russell, John

    2015-09-18

    We study asymmetric dark matter (ADM) in the context of the minimal (fraternal) twin Higgs solution to the little hierarchy problem, with a twin sector with gauged SU(3)^{'}×SU(2)^{'}, a twin Higgs doublet, and only third-generation twin fermions. Naturalness requires the QCD^{'} scale Λ_{QCD}^{'}≃0.5-20  GeV, and that t^{'} is heavy. We focus on the light b^{'} quark regime, m_{b^{'}}≲Λ_{QCD}^{'}, where QCD^{'} is characterized by a single scale Λ_{QCD}^{'} with no light pions. A twin baryon number asymmetry leads to a successful dark matter (DM) candidate: the spin-3/2 twin baryon, Δ^{'}∼b^{'}b^{'}b^{'}, with a dynamically determined mass (∼5Λ_{QCD}^{'}) in the preferred range for the DM-to-baryon ratio Ω_{DM}/Ω_{baryon}≃5. Gauging the U(1)^{'} group leads to twin atoms (Δ^{'}-τ^{'}[over ¯] bound states) that are successful ADM candidates in significant regions of parameter space, sometimes with observable changes to DM halo properties. Direct detection signatures satisfy current bounds, at times modified by dark form factors. PMID:26430985

  20. Twins and Kindergarten Separation: Divergent Beliefs of Principals, Teachers, Parents, and Twins

    Science.gov (United States)

    Gordon, Lynn Melby

    2015-01-01

    Should principals enforce mandatory separation of twins in kindergarten? Do school separation beliefs of principals differ from those of teachers, parents of twins, and twins themselves? This survey questioned 131 elementary principals, 54 kindergarten teachers, 201 parents of twins, and 112 twins. A majority of principals (71%) believed that…

  1. Best Practices for Twin Placement in School

    Science.gov (United States)

    Lacina, Jan

    2012-01-01

    The children's book "Two Is for Twins" celebrates twins and illustrates the many "twos" in a child's world. The uniqueness of twos does not have to mean separate classrooms for twins in child development programs, preschool, or elementary school settings. With recent dramatic increases in the US twin population, how should educators address the…

  2. The vector-like twin Higgs

    Science.gov (United States)

    Craig, Nathaniel; Knapen, Simon; Longhi, Pietro; Strassler, Matthew

    2016-07-01

    We present a version of the twin Higgs mechanism with vector-like top partners. In this setup all gauge anomalies automatically cancel, even without twin leptons. The matter content of the most minimal twin sector is therefore just two twin tops and one twin bottom. The LHC phenomenology, illustrated with two example models, is dominated by twin glueball decays, possibly in association with Higgs bosons. We further construct an explicit four-dimensional UV completion and discuss a variety of UV completions relevant for both vector-like and fraternal twin Higgs models.

  3. The Vector-like Twin Higgs

    CERN Document Server

    Craig, Nathaniel; Longhi, Pietro; Strassler, Matthew

    2016-01-01

    We present a version of the twin Higgs mechanism with vector-like top partners. In this setup all gauge anomalies automatically cancel, even without twin leptons. The matter content of the most minimal twin sector is therefore just two twin tops and one twin bottom. The LHC phenomenology, illustrated with two example models, is dominated by twin glueball decays, possibly in association with Higgs bosons. We further construct an explicit four-dimensional UV completion and discuss a variety of UV completions relevant for both vector-like and fraternal twin Higgs models.

  4. Fivefold twinned boron carbide nanowires.

    Science.gov (United States)

    Fu, Xin; Jiang, Jun; Liu, Chao; Yuan, Jun

    2009-09-01

    Chemical composition and crystal structure of fivefold twinned boron carbide nanowires have been determined by electron energy-loss spectroscopy and electron diffraction. The fivefold cyclic twinning relationship is confirmed by systematic axial rotation electron diffraction. Detailed chemical analysis reveals a carbon-rich boron carbide phase. Such boron carbide nanowires are potentially interesting because of their intrinsic hardness and high temperature thermoelectric property. Together with other boron-rich compounds, they may form a set of multiply twinned nanowire systems where the misfit strain could be continuously tuned to influence their mechanical properties.

  5. Failure of vincristine induce twinning

    Science.gov (United States)

    Binder, M.

    1984-01-01

    Mammalian ova do not contain axes of symmetry from which are derived embryonic axes of symmetry. Mammalian axis determination is an early embryologic event occurring at about the time that monozygous twinning in mice. (Kaufma MH & O'Shea KS, 1978, Nature 276:707) and an attempt was made to reproduce their work in several strains of mice. Over 3200 embryos were examined without any twins being found. To rule out the possibility that vincristine caused twinning plus some lethal malformation (with subsequent resorption of the embryo) the embryos were examined 36-60 hours after vincristine treatment.

  6. Maggot excretions affect the human complement system.

    Science.gov (United States)

    Cazander, Gwendolyn; Schreurs, Marco W J; Renwarin, Lennaert; Dorresteijn, Corry; Hamann, Dörte; Jukema, Gerrolt N

    2012-01-01

    The complement system plays an important role in the activation of the inflammatory response to injury, although inappropriate complement activation (CA) can lead to severe tissue damage. Maggot therapy is successfully used to treat infected wounds. In this study, we hypothesized that maggot excretions/secretions influence CA in order to modulate the host's inflammatory response. Therefore, the effect of maggot excretions on CA was investigated in preoperatively and postoperatively obtained sera from patients. Our results show that maggot excretions reduce CA in healthy and postoperatively immune-activated human sera up to 99.9%, via all pathways. Maggot excretions do not specifically initiate or inhibit CA, but break down complement proteins C3 and C4 in a cation-independent manner and this effect proves to be temperature tolerant. This study indicates a CA-reducing substrate that is already successfully used in clinical practice and may explain part of the improved wound healing caused by maggot therapy. Furthermore, the complement activation-reducing substance present in maggot excretions could provide a novel treatment modality for several diseases, resulting from an (over)active complement system.

  7. Identical twins in forensic genetics

    DEFF Research Database (Denmark)

    Tvedebrink, Torben; Morling, Niels

    2015-01-01

    The increase in the number of forensic genetic loci used for identification purposes results in infinitesimal random match probabilities. These probabilities are computed under assumptions made for rather simple population genetic models. Often, the forensic expert reports likelihood ratios, where...... relationship, i.e., identical (monozygotic) twins, when reporting the weight of evidence. This can be done even when the suspect has no knowledge of an identical twin or when official records hold no twin information about the suspect. The derived expressions are not original as several authors previously have...... published results accounting for close familial relationships. However, we revisit the discussion to increase the awareness among forensic genetic practitioners and include new information on medical and societal factors to assess the risk of not considering a monozygotic twin as the true perpetrator...

  8. Twin-to-twin transfusion syndrome : from placental anastomoses to long-term outcome

    NARCIS (Netherlands)

    Lopriore, Enrico

    2006-01-01

    Twin-to-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies associated with high perinatal mortality and morbidity rates. Placental vascular anastomoses, almost invariably present in monochorionic placentas, are the essential anatomical substrate for the devel

  9. The Danish political twin study

    DEFF Research Database (Denmark)

    Klemmensen, Robert; Hobolt, Sara B; Dinesen, Peter Thisted;

    2012-01-01

    We compare a recent Danish twin survey on political attitudes and behaviors to a nationally representative survey covering similar topics. We find very similar means and variances for most of our constructed scales of political attitudes and behaviors in the two surveys, although even small...... differences tend to be statistically significant due to sample size. This suggests that the twin study can be used to make inferences on the heritability of several political traits in the Danish population....

  10. Aragonite twinning in gastropod nacre

    Science.gov (United States)

    Mukai, Hiroki; Saruwatari, Kazuko; Nagasawa, Hiromichi; Kogure, Toshihiro

    2010-10-01

    Aragonite twinning in gastropod nacre has been investigated using scanning electron microscopy (SEM), electron back-scattered diffraction (EBSD), and transmission electron microscopy (TEM) with the focused ion beam (FIB) sample preparation technique. At the growth front of nacre, Haliotis discus hannai and Omphalius rusticus form a "stack-of-coins" structures, which consist of pseudo-hexagonal and elliptical aragonite tablets, respectively. SEM, EBSD, and TEM analyses revealed that these tablets are monolithic single crystal and almost free of the {1 1 0} twins that are common in aragonite of biotic or abiotic origin. The longest diagonal of the hexagon and the longer axis of the ellipse are parallel to the a-axis of aragonite. The crystal orientation of each tablet in a stack, measured by TEM-Kikuchi pattern analysis, is almost the same but there is occasionally {1 1 0} twin-like relationship between adjacent tablets along the stacking. On the other hand, the fibrous aragonite layer formed prior to the nacreous structure is composed of polycrystalline aragonite with high density of {1 1 0} twins. TEM observation suggests that the interlamellar organic sheet prevents the inheritance of the twins, by selecting only single domain of the twins, through the mineral bridge.

  11. Intestinal excretion of metals by rats

    International Nuclear Information System (INIS)

    The excretion of 65Zn, sup(115m)Cd, 203Hg, 207Bi, 210Pb, 60Co, 64Cu, 85Sr and 86Rb in the perfused sections of the intestinal tract in vivo was investigated by the pendular perfusion method. After intravenous administration the excretion of metals was investigated in the jejunum, in the colon and in some experiments also in the ileum. The fluid net movement in the jejunum and colon was measured in dependency on the energy spectrum of the applied metal isotope by means of 14C or 3H-polyethylene glycol 2000. (orig./MG)

  12. Albumin gene expression is down-regulated by albumin or macromolecule infusion in the rat.

    OpenAIRE

    Pietrangelo, A; Panduro, A; Chowdhury, J R; Shafritz, D A

    1992-01-01

    A novel feedback regulatory mechanism operating on transcription of the albumin gene is described in the rat. In 1946, it was proposed that circulating colloids, including serum albumin, may affect the synthesis and/or secretion of albumin in the liver. The molecular basis for this proposed regulation has now been investigated by adding oncotically active macromolecules to the circulation of normal or genetically albumin-deficient Nagase analbuminemic rats (NAR) and analyzing the hepatic expr...

  13. Profile of total protein, albumin, globulin and albumin globulin ratio in bulls

    OpenAIRE

    Ida Zahidah Irfan; Esfandiari, A; C Choliq

    2014-01-01

    Determination of serum total protein concentration and main fractions (albumin and globulin) can be used as an important diagnostic tool in clinical biochemistry. Several factors can affect the concentration of total protein, albumin, globulin and albumin globulin ratio (A/G). The aim of this study is to obtain serum protein profiles, albumin, globulin and A/G ratio based on breed, age and BCS (body condition score). Blood samples from 160 bulls were collected. Blood chemistry were analyzed ...

  14. Correlation of albumin concentration and ischemia modified albumin in the diagnosis of acute myocardial infarction

    OpenAIRE

    K, Arun Kumar; Uthappa, Sheila; Surendran, Sudarshan; Michael, Martina; S., Sushitha E.

    2015-01-01

    Objectives:  To find out if there is any relationship between serum level of albumin and IMA estimated by albumin cobalt binding assay. The effectiveness of albumin adjusted IMA index in the diagnosis of Acute Myocardial Infarction (AMI) was also studied.Material and methods: We analyzed serum levels of IMA and albumin adjusted IMA index in 120 patients each with acute myocardial infarction (AMI) and apparently healthy subjects belonging to the control group. Further, both control and AMI gro...

  15. Preparation and characterization of microspheres of albumin-heparin conjugates

    NARCIS (Netherlands)

    Kwon, Glen S.; Bae, You Han; Kim, Sung Wan; Cremers, Harry; Feijen, Jan

    1991-01-01

    Albumin-heparin microspheres have been prepared as a new drug carrier. A soluble albumin-heparin conjugate was synthesized by forming amide bonds between human serum albumin and heparin. After purification the albumin-heparin conjugate was crosslinked in a water-in-oil emulsion to form albumin-hepar

  16. Twin Towers of Hanoi

    CERN Document Server

    Sunic, Zoran

    2011-01-01

    In the Twin Towers of Hanoi version of the well known Towers of Hanoi Problem there are two coupled sets of pegs. In each move, one chooses a pair of pegs in one of the sets and performs the only possible legal transfer of a disk between the chosen pegs (the smallest disk from one of the pegs is moved to the other peg), but also, simultaneously, between the corresponding pair of pegs in the coupled set (thus the same sequence of moves is always used in both sets). We provide upper and lower bounds on the length of the optimal solutions to problems of the following type. Given an initial and a final position of N disks in each of the coupled sets, what is the smallest number of moves needed to simultaneously obtain the final position from the initial one in each set? Our analysis is based on the use of a group, called Hanoi Towers group, of rooted ternary tree automorphisms, which models the original problem in such a way that the configurations on N disks are the vertices at level N of the tree and the action...

  17. ALBUMIN AS PROGNOSTIC VALUE IN HOSPITALISED PATIENTS

    Directory of Open Access Journals (Sweden)

    Chakrapani Alavala

    2016-07-01

    Full Text Available BACKGROUND In cases of a pathological state, there might be a low formation of the albumin in liver or high degradation of the albumin. In either of the ways, the serum albumin will be lowered. Stress and strain is also known to cause hypoalbuminemia i.e. low serum level of albumin. Since albumin is a protein, it has to be transcribed from the genes and studies have shown that TNF-alpha supresses this transcription process. The TNF-alpha is known to increase in any inflammation and thus forms a cascade. In case of hospitalised patients, the stress and strain in pre-surgical patients and chronically hospitalised patients, the serum albumin levels are known to be less than normal. In chronically hospitalised patients, the nutritional cause can also be taken into consideration for lower serum albumin levels. Early detection of these low levels of serum albumin levels helps the surgeons and the physicians to intervene and thus cut off the progression of the disease. A sincere effort has been made in this study to understand the relations of the serum albumin level and its effects on the prognosis of the disease and outcome of the surgery if the patient is undergoing any. This study is intended to help the physician, surgeon, and general practitioners to understand and intervene in the event and thus help the patient to recover earlier and in a better way. METHODS Aim of the study is to estimate the mean serum albumin levels in hospitalised patients to estimate the mean serum albumin levels in patients undergoing surgery and to correlate the serum albumin levels and the prognosis of the patient. The study has been done in the Department of Surgery, Government Medical College, Nizamabad. The study was done from October 2013 to November 2014. The study is a cross-sectional study. The study is also double blinded and randomised. The study is a multi-level study. The sample size included one hundred patients. One hundred patients were identified in the

  18. Congenital ocular motor apraxia associated with idiopathic generalized epilepsy in monozygotic twins.

    Science.gov (United States)

    Gonzalez-Martin, J A; Kaye, L C; Brown, M; Ellis, I; Appelton, R; Kaye, S B

    2004-06-01

    Identical female twins (age 11 years) with congenital ocular motor apraxia and generalized idiopathic epilepsy are reported. Their presenting symptoms were a long history of abnormal head and eye movements. One twin developed partial sensory seizures. The patients underwent 16-channel EEG, electro-oculographic recordings, MRI of the brain, and genetic and metabolic investigations. EEG findings were consistent with idiopathic generalized epilepsy. Electrooculographic recordings of the saccades confirmed an inability to elicit horizontal saccades without preceding head movement; saccades to the left were better than saccades to the right. MR scans for one twin showed normal findings, however, for the twin who had meningitis they revealed asymmetry between the right and left temporal lobes but no specific abnormality. DNA analysis using a series of autosomal polymorphic markers confirmed the monozygocity of the twins. White blood cell enzyme analysis excluded Sandhoff disease, Tay-Sachs disease, GM1 gangliosidosis, metacromatic leucodystrophy, Gaucher disease, Niemann-Pick disease (A and B), and Krabbe leucodystrophy. Albumin and immunoglobulin (IgA, IgG, and IgM) levels were normal. It is concluded that autosomal recessive inheritance seems the most likely explanation here, as recent studies have found insertion and missense mutations of the aprataxin gene which have been related to an early onset form of ataxia with ocular motor apraxia and hypoalbuminaemia. PMID:15174536

  19. Urinary growth hormone excretion in acromegaly

    DEFF Research Database (Denmark)

    Main, K M; Lindholm, J; Vandeweghe, M;

    1993-01-01

    The biochemical assessment of disease activity in acromegaly still presents a problem, especially in treated patients with mild clinical symptoms. We therefore examined the diagnostic value of the measurement of urinary growth hormone (GH) excretion in seventy unselected patients with acromegaly...

  20. Urinary excretion of Iopamidol following intrathecal administration.

    Science.gov (United States)

    Pitrè, D; Zingales, M F; Trevisan, C

    1983-01-01

    No iodinated compound other than Iopamidol was found in the urine of subjects who received intrathecal injection of 10 ml of Iopamiro "300". The compound was neither metabolized nor altered in its optical configuration and urinary iodide content was always in the normal range. Between 72 and 85% of injected Iopamidol was excreted within 72 h of injection.

  1. Power Functions Relating Excretion to Body Burden

    CERN Document Server

    Sanders, S M J

    2003-01-01

    Formulae necessary to relate the quantity of radionuclides excreted to that assimilated in exposures that are acute and those that are multiple or continuous are derived from power function relationships. Particular attention is given to providing equations having variables for which the bioassayer can easily derive numerical values. This paper presents this data.

  2. [Twin pregnancy complicated by intrauterine death of one twin].

    Science.gov (United States)

    Wilczyński, J; Jaczewski, B; Nowakowska, D; Wysocki, K; Szaflik, K; Oszukowski, P; Krasomski, G; Czichos, E

    2000-11-01

    In twin pregnancies single intrauterine death of one fetus is associated with significant morbidity and mortality of the surviving infant. The aims of our retrospective study were to review conditions of twin pregnancies complicated with SIUD in Polish Mother's Memorial Hospital in Łódź between 1989-1999 and to assess the fetal outcome when conservative management had undergone. In this study we reviewed 30 twin gestations involving the intrauterine death of one fetus. The incidence of preterm delivery among pregnancies with fetal death was 83.3%; Caesarean section was the method of delivery in 53.3% cases. Monochorionic placentation was found in 60%. Conservative management until there is no risk for the fetus is apt. PMID:11216164

  3. Total Protein and Albumin/Globulin Ratio Test

    Science.gov (United States)

    ... limited. Home Visit Global Sites Search Help? Total Protein and Albumin/Globulin (A/G) Ratio Share this ... Globulin Ratio; A/G Ratio Formal name: Total Protein; Albumin to Globulin Ratio Related tests: Albumin ; Liver ...

  4. TwinMux Testing System

    CERN Document Server

    Wong, Wei Wen; CERN. Geneva. PH Department

    2015-01-01

    During the CERN summer school program, I joined the CMS Muon Drift Tube (DT) group, and mainly worked on two projects, which, both of them, are related to the electronics of a new data concentrator called the “TwinMux”. My first task within the TwinMux project was to build an integrated software test station in order to run several tests on the functionality of the TwinMux hardware. Essentially, I had to integrate existing testing scripts, adding several new ones, into a single user-friendly testing platform which can perform quick, convenient and automated hardware testing. Later, I was also involved in the design of the local technical triggering of the DT. Such system relies on some firmware functionality built in the TwinMux and controlled by software. I had attempted two different approaches to design the communication topology of all the 12 TwinMux cards in order to send a user-defined logical operation to the read-out electronics. The final goal of this system is to drive local trigger signal for...

  5. Drug binding properties of neonatal albumin

    DEFF Research Database (Denmark)

    Brodersen, R; Honoré, B

    1989-01-01

    Neonatal and adult albumin was isolated by gel chromatography on Sephacryl S-300, from adult and umbilical cord serum, respectively. Binding of monoacetyl-diamino-diphenyl sulfone, warfarin, sulfamethizole, and diazepam was studied by means of equilibrium dialysis and the binding data were analyzed...... by the method of several acceptable fitted curves. It was found that the binding affinity to neonatal albumin is less than to adult albumin for monoacetyl-diamino-diphenyl sulfone and warfarin. Sulfamethizole binding to the neonatal protein is similarly reduced when more than one molecule of the drug...... is bound per albumin molecule, and binding of the first sulfamethizole molecule is possibly reduced as well. Diazepam binds with equal affinity to the fetal and adult proteins. Among the two main albumin drug-binding functions, for warfarin and diazepam, the former is thus compromised in the newborn...

  6. Fibrinogen adsorption on blocked surface of albumin

    DEFF Research Database (Denmark)

    Holmberg, Maria; Hou, Xiaolin

    2011-01-01

    We have investigated the adsorption of albumin and fibrinogen onto PET (polyethylene terephthalate) and glass surfaces and how pre-adsorption of albumin onto these surfaces can affect the adsorption of later added fibrinogen. For materials and devices being exposed to blood, adsorption...... of fibrinogen is often a non-wanted event, since fibrinogen is part of the clotting cascade and unspecific adsorption of fibrinogen can have an influence on the activation of platelets. Albumin is often used as blocking agent for avoiding unspecific protein adsorption onto surfaces in devices designed to handle...... energies, the adsorption of both albumin and fibrinogen has been monitored simultaneously on the same sample. Information about topography and coverage of adsorbed protein layers has been obtained using AFM (Atomic Force Microscopy) analysis in liquid. Our studies show that albumin adsorbs in a multilayer...

  7. Preparation and characterization of microspheres of albumin-heparin conjugates

    OpenAIRE

    Kwon, Glen S.; Bae, You Han; Kim, Sung Wan; Cremers, Harry; Feijen, Jan

    1991-01-01

    Albumin-heparin microspheres have been prepared as a new drug carrier. A soluble albumin-heparin conjugate was synthesized by forming amide bonds between human serum albumin and heparin. After purification the albumin-heparin conjugate was crosslinked in a water-in-oil emulsion to form albumin-heparin microspheres. The composition of the conjugate was determined by amino acid analysis. The swelling properties of albumin-heparin microspheres were investigated as a function of pH and ionic stre...

  8. Risk of Oral Clefts in Twins

    DEFF Research Database (Denmark)

    Grosen, Dorthe; Bille, Camilla; Petersen, Inge;

    2011-01-01

    BACKGROUND:: Small studies have indicated that twinning increases the risk of oral cleft. METHODS:: We used data from a Danish national population-based cohort study to investigate whether twinning was associated with isolated oral cleft, and to estimate the twin probandwise concordance rate...... and heritability. Twins (207 affected/130,710) and singletons (7766 affected/4,798,526) born from 1936 through 2004 in Denmark were ascertained by linkage among the Danish Facial Cleft Database, the Danish Twin Registry, and the Civil Registration System. We computed oral cleft prevalence and prevalence proportion...... ratio for twins versus singletons, stratified for 3 subphenotypes. Probandwise concordance rates and heritability for twins were estimated for 2 phenotypes-cleft lip with or without cleft palate (CL/P) and cleft palate (CP). RESULTS:: The prevalence of oral cleft was 15.8 per 10,000 twins and 16.6 per...

  9. Nike Twins Seven Seven: Nigerian Batik Artist.

    Science.gov (United States)

    LaDuke, Betty

    1987-01-01

    Chronicles the personal and professional life of Nike Twins Seven Seven (born 1951), a Nigerian batik artist, and her husband, Twins Seven Seven, a musician-artist, both of whom have received international acclaim. (BJV)

  10. A Little Twin Higgs Model

    Energy Technology Data Exchange (ETDEWEB)

    Goh, Hock-Seng; Goh, Hock-Seng; Krenke, Christopher A.

    2007-07-25

    We present a twin Higgs model based on left-right symmetry with a tree level quartic. This is made possible by extending the symmetry of the model to include two Z_2 parities, each of which is sufficient to protect the Higgs from getting a quadratically divergent mass squared. Although both parities are brokenexplicitly, the symmetries that protect the Higgs from getting a quadratically divergent mass are broken only collectively. The quadratic divergences of the Higgs mass are thus still protected at one loop. We find that the fine-tuning in this model is reduced substantially compared to the original left-right twin Higgs model. This mechanism can also be applied to the mirror twin Higgs model to get a significant reduction of the fine-tuning, while keeping the mirror photon massless.

  11. A Little Twin Higgs Model

    CERN Document Server

    Goh, Hock-Seng

    2007-01-01

    We present a twin Higgs model based on left-right symmetry with a tree level quartic. This is made possible by extending the symmetry of the model to include two Z_2 parities, each of which is sufficient to protect the Higgs from getting a quadratically divergent mass squared. Although both parities are broken explicitly, the symmetries that protect the Higgs from getting a quadratically divergent mass are broken only collectively. The quadratic divergences of the Higgs mass are thus still protected at one loop. We find that the fine tuning in this model is reduced substantially compared to the original left-right twin Higgs model. This mechanism can also be applied to the mirror twin Higgs model to get a significant reduction of the fine tuning, while keeping the mirror photon massless.

  12. Complications arising in twin pregnancy: findings of prenatal ultrasonography

    International Nuclear Information System (INIS)

    Multifetal gestations are high-risk pregnancies involving higher perinatal morbidity and mortality, and are subject to unique complications including twin oligohydramnios- polyhydramnios sequence, twin-to-twin transfusion syndrome, acardiac twins, conjoined twins, co-twin demise, and heterotopic pregnancies. The purpose of this study is to describe the prenatal ultrasonographic and pathologic findings of these complications

  13. Complications Arising in Twin Pregnancy: Findings of Prenatal Ultrasonography

    OpenAIRE

    Kim, Jeong-Ah; Cho, Jeong Yeon; Lee, Young Ho; Song, Mi Jin; Min, Jee-Yeon; Lee, Hak Jong; Han, Byoung Hee; Lee, Kyung-Sang; Cho, Byung Jae; Chun, Yi-Kyeong

    2003-01-01

    Multifetal gestations are high-risk pregnancies involving higher perinatal morbidity and mortality, and are subject to unique complications including twin oligohydramnios-polyhydramnios sequence, twin-to-twin transfusion syndrome, acardiac twins, conjoined twins, co-twin demise, and heterotopic pregnancies. The purpose of this study is to describe the prenatal ultrasonographic and pathologic findings of these complications.

  14. Complications arising in twin pregnancy: findings of prenatal ultrasonography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Ah; Cho, Jeong Yeon; Lee, Young Ho; Song, Mi Jin; Min, Jee Yeon; Lee, Hak Jong; Han, Byoung Hee; Lee, Kyung Sang; Cho, Byung Jae; Chun, Yi Kyeong [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2003-03-01

    Multifetal gestations are high-risk pregnancies involving higher perinatal morbidity and mortality, and are subject to unique complications including twin oligohydramnios- polyhydramnios sequence, twin-to-twin transfusion syndrome, acardiac twins, conjoined twins, co-twin demise, and heterotopic pregnancies. The purpose of this study is to describe the prenatal ultrasonographic and pathologic findings of these complications.

  15. LORRY DRIVERS WORK STRESS EVALUATED BY CATECHOLAMINES EXCRETED IN URINE

    NARCIS (Netherlands)

    VANDERBEEK, AJ; MEIJMAN, TF; FRINGSDRESEN, MHW; KUIPER, JI

    1995-01-01

    Objectives-To evaluate lorry drivers' work stress by measurement of adrenaline and noradrenaline excreted in the urine, and to find out which factors in their working situation are related to the excretion rates of these catecholamines. Methods-The urinary excretion of adrenaline and noradrenaline o

  16. TWIN REVERSED ARTERIAL PERFUSION SEQUENCE (ACARDIAC TWIN: A RARE CASE REPORT

    Directory of Open Access Journals (Sweden)

    Chidambaram Ramesh

    2015-12-01

    Full Text Available Acardiac twin is a rare congenital anomaly and is exclusively associated with monochorionic twin pregnancy. It is due to abnormal placental vascular communication between the two fetuses in the form of arterioarterial and venovenous communication (reversed perfusion. Acardiac twin receives blood from the pump twin. Twin Reversed Arterial Perfusion (TRAP is a rare complication of monochorionic twins. TRAP sequence is known as acardius or chorioangiopagus parasiticus. It occurs in 1% of monochorionic twin pregnancies and in 1 in 35,000 pregnancies. We report a rare case of acardiac twin, the incidence among 1 in 80229 of total deliveries and 1 in 1922 of twin pregnancies (From January 2010 to September 2015 in our institution. Hence, we present this rare interesting case of acardiac twin (TRAP SEQUENCE diagnosed and delivered at our institution.

  17. Epigenetic Epidemiology of Complex Diseases Using Twins

    DEFF Research Database (Denmark)

    Tan, Qihua

    2013-01-01

    through multiple epigenetic mechanisms. This paper reviews the new developments in using twins to study disease-related epigenetic alterations, links them to lifetime environmental exposure with a focus on the discordant twin design and proposes novel data-analytical approaches with the aim of promoting...... a more efficient use of twins in epigenetic studies of complex human diseases....

  18. Concordance for multiple sclerosis in Danish twins

    DEFF Research Database (Denmark)

    Hansen, T; Skytthe, Axel; Stenager, Egon;

    2005-01-01

    The occurrence of multiple sclerosis (MS) in twins has not previously been studied in complete nationwide data sets. The existence of almost complete MS and twin registries in Denmark ensures that essentially unbiased samples of MS cases among twins can be obtained. In this population-based study...

  19. MIR phasing using merohedrally twinned crystals

    NARCIS (Netherlands)

    Terwisscha van Scheltinga, Anke C.; Valegård, Karin; Hajdu, Janos; Andersson, Inger

    2003-01-01

    Merohedral twinning is a crystal-growth disorder that seriously hinders the determination of macromolecular crystal structures by isomorphous replacement. The strategies used in the structures solved so far are discussed. Several methods can be used to determine the extent of twinning, the twin frac

  20. Effects of hypothyroidism on vascular 125I-albumin permeation and blood flow in rats

    International Nuclear Information System (INIS)

    Effects of hypothyroidism on vascular 125I-albumin permeation and on blood flow were assessed in multiple tissues of male Sprague-Dawley rats rendered hypothyroid by dietary supplementation with 0.5% (wt/wt) 2-thiouracil or by thyroidectomy. In both thiouracil-treated and thyroidectomized rats, body weights, kidney weight, arterial blood pressure, and pulse rate were decreased significantly v age-matched controls. After 10 to 12 weeks of thiouracil treatment, 125I-albumin permeation was increased significantly in the kidney, aorta, eye (anterior uvea, choroid, retina), skin, and new granulation tissue, remained unchanged in brain, sciatic nerve, and heart, and was decreased in forelimb skeletal muscle. A similar pattern was observed in thyroidectomized rats, except that increases in 125I-albumin permeation for all tissues were smaller than those observed in thiouracil-treated rats, and 125I-albumin permeation in retina did not differ from controls. In both thiouracil-treated and thyroidectomized rats, changes in blood flow (assessed with 15-microns, 85Sr-labeled microspheres) relative to the decrease in arterial blood pressure were indicative of a decrease in regional vascular resistance except in the choroid and in the kidney, in which vascular resistance was increased significantly. Glomerular filtration rate was decreased, but filtration fraction and urinary excretion of albumin remained unchanged by thiouracil treatment and thyroidectomy. These results indicate that vascular hemodynamics and endothelial cell barrier functional integrity are modulated in many different tissues by the thyroid. In view of the correspondence of hypothyroid- and diabetes-induced vascular permeability changes, these results raise the possibility that altered thyroid function in diabetes may play a role in the pathogenesis of diabetic vascular disease

  1. The 'Planemo' Twins

    Science.gov (United States)

    2006-08-01

    The cast of exoplanets has an extraordinary new member. Using ESO's telescopes, astronomers have discovered an approximately seven-Jupiter-mass companion to an object that is itself only twice as hefty. Both objects have masses similar to those of extra-solar giant planets, but they are not in orbit around a star - instead they appear to circle each other. The existence of such a double system puts strong constraints on formation theories of free-floating planetary mass objects. ESO PR Photo 29a/06 ESO PR Photo 29a/06 Double System of Planetary Mass Objects (Artist's View) Ray Jayawardhana of the University of Toronto (Canada) and Valentin D. Ivanov of ESO report the discovery in the August 3 issue of Science Express, the rapid online publication service of the journal Science. "This is a truly remarkable pair of twins - each having only about one percent the mass of our Sun," said Jayawardhana. "Its mere existence is a surprise, and its origin and fate a bit of a mystery." Roughly half of all Sun-like stars come in pairs. So do about a sixth of brown dwarfs, 'failed stars' that have less than 75 Jupiter masses and are unable to sustain nuclear fusion in their cores. During the past five years, astronomers have identified a few dozen of even smaller free-floating planetary mass objects, or planemos, in nearby star forming regions. Oph 162225-240515, or Oph1622 for short, is the first planemo found to be a double. The researchers discovered the companion candidate in an optical image taken with ESO's 3.5-m New Technology Telescope at La Silla, Chile. They decided to take optical spectra and infrared images of the pair with ESO's 8.2-m Very Large Telescope to make sure that it is a true companion, instead of a foreground or background star that happens to be in the same line of sight. These follow up observations indeed confirmed that both objects are young, at the same distance, and much too cool to be stars. This suggests the two are physically associated. ESO PR

  2. Contribution to biorhythm of mercury-excretion

    Energy Technology Data Exchange (ETDEWEB)

    Thiele, H.; Damrau, J.; Franzen, E.; Henkel, W.

    1988-07-01

    The timed urinary mercury-excretion was investigated in 27 formerly exposed. The interval since their last exposure, their age, state of health and duration of exposure differed considerably. Nevertheless a clear circadian rhythm was found by adjustment of mercury to the timed substance-quantity, less to specific gravity, but really not to creatinin. These relations should be considered in biomonitoring. The differences of biorhythm in healthy and mercury-injured persons are discussed.

  3. Urinary porphyrin excretion in hepatitis C infection

    OpenAIRE

    Vogeser, Michael; Jacob, Karl; Zachoval, Reinhart

    1999-01-01

    A high prevalence of hepatitis C virus infection in porphyria cutanea tarda in some populations suggests a close link between viral hepatitis and alteration of porphyrin metabolism. Moreover, there is evidence of a role of porphyrinopathies in hepatocarcinogenesis. The aim of our study was to obtain data on the prevalence and patterns of heme metabolism alterations in patients with chronic hepatitis C virus infection. Urinary porphyrin excretion was prospectively studied in 100 consecutive ou...

  4. Urine alkalization facilitates uric acid excretion

    Directory of Open Access Journals (Sweden)

    Seyama Issei

    2010-10-01

    Full Text Available Abstract Background Increase in the incidence of hyperuricemia associated with gout as well as hypertension, renal diseases and cardiovascular diseases has been a public health concern. We examined the possibility of facilitated excretion of uric acid by change in urine pH by managing food materials. Methods Within the framework of the Japanese government's health promotion program, we made recipes which consist of protein-rich and less vegetable-fruit food materials for H+-load (acid diet and others composed of less protein but vegetable-fruit rich food materials (alkali diet. Healthy female students were enrolled in this consecutive 5-day study for each test. From whole-day collected urine, total volume, pH, organic acid, creatinine, uric acid and all cations (Na+,K+,Ca2+,Mg2+,NH4+ and anions (Cl-,SO42-,PO4- necessary for the estimation of acid-base balance were measured. Results Urine pH reached a steady state 3 days after switching from ordinary daily diets to specified regimens. The amount of acid generated ([SO42-] +organic acid-gut alkai were linearly related with those of the excretion of acid (titratable acidity+ [NH4+] - [HCO3-], indicating that H+ in urine is generated by the metabolic degradation of food materials. Uric acid and excreted urine pH retained a linear relationship, where uric acid excretion increased from 302 mg/day at pH 5.9 to 413 mg/day at pH 6.5, despite the fact that the alkali diet contained a smaller purine load than the acid diet. Conclusion We conclude that alkalization of urine by eating nutritionally well-designed food is effective for removing uric acid from the body.

  5. Four twins for a paradox: On ``sensitive'' twins and the biological counterpart of the ``twin paradox''

    Science.gov (United States)

    Ascioti, Fortunato A.

    2009-03-01

    Monozygotic twin (MZT) epigenetic development, i.e., aging, diverges largely in time despite the initially very small genetic differences between MZTs. This fact is interpreted as a "sensitivity to initial conditions" phenomenon, a common property of either deterministic or stochastic chaotic systems. Some of the biotheoretical implications stemming from this empirical observation are briefly discussed here, while an actual measure of MZT epigenetic time divergence is given through an estimate of the (Stochastic) Lyapunov exponents (LEs) (i.e., the rate of exponential time divergence). These results suggest a reconsideration of the Langevin-Einstein thought experiment known as the "twin paradox." At least four twins are necessary in order to take into account the inertially independent divergent aging described here. Alternatively, LE estimates, like those given here, should be used. Finally suggested in the actual special-relativity experiments is the replacement of clocks with some nonlinear (chaotic) forced oscillator.

  6. Increasing cardiac output and decreasing oxygenation sequence in pump twins of acardiac twin pregnancies

    International Nuclear Information System (INIS)

    An acardiac twin pregnancy is a rare but serious complication of monochorionic twinning and consists of an acardiac twin and a pump twin. The acardiac twin is a severely malformed fetus that lacks most organs, particularly a heart, but grows during pregnancy because it is perfused by the developmentally normal pump twin via a set of arterioarterial and venovenous placental anastomoses. Pump twins die intrauterine or neonatally in about 50% of the cases. Because the effects of an acardiac mass on the pump twin's development are incompletely known, methods for outcome prognosis are currently not available. We sought to derive simple relations for the pump twin's excess cardiac output and decreased oxygenation and to use available clinical cases for a preliminary test of the model. As a method, we used a theoretical flow model to represent the fetoplacental circulation of an acardiac twin pregnancy and estimated blood deoxygenation and reoxygenation following perfusion of the two bodies and placentas, respectively. The results show the pump twin's excess cardiac output and decrease of venous oxygen saturation to depend on the ratio of pump twin to acardiac twin umbilical blood flow, whose ratio can be measured by ultrasonography. The clinical cases show a decreasing umbilical flow ratio with gestation. In conclusion, prospective serial study is necessary to test whether measurement of umbilical flow ratios allows monitoring the pump twin's pathophysiologic development, possibly resulting in a guideline for prognosis of pump twin survival. (note)

  7. Increasing cardiac output and decreasing oxygenation sequence in pump twins of acardiac twin pregnancies

    Energy Technology Data Exchange (ETDEWEB)

    Gemert, Martin J C van [Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam (Netherlands); Umur, Asli [Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam (Netherlands); Wijngaard, Jeroen P H M van den [Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam (Netherlands); VanBavel, Ed [Department of Medical Physics, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands); Vandenbussche, Frank P H A [Department of Obstetrics, Leiden University Medical Center, Leiden (Netherlands); Nikkels, Peter G J [Department of Pathology, University Medical Center, Utrecht (Netherlands)

    2005-02-07

    An acardiac twin pregnancy is a rare but serious complication of monochorionic twinning and consists of an acardiac twin and a pump twin. The acardiac twin is a severely malformed fetus that lacks most organs, particularly a heart, but grows during pregnancy because it is perfused by the developmentally normal pump twin via a set of arterioarterial and venovenous placental anastomoses. Pump twins die intrauterine or neonatally in about 50% of the cases. Because the effects of an acardiac mass on the pump twin's development are incompletely known, methods for outcome prognosis are currently not available. We sought to derive simple relations for the pump twin's excess cardiac output and decreased oxygenation and to use available clinical cases for a preliminary test of the model. As a method, we used a theoretical flow model to represent the fetoplacental circulation of an acardiac twin pregnancy and estimated blood deoxygenation and reoxygenation following perfusion of the two bodies and placentas, respectively. The results show the pump twin's excess cardiac output and decrease of venous oxygen saturation to depend on the ratio of pump twin to acardiac twin umbilical blood flow, whose ratio can be measured by ultrasonography. The clinical cases show a decreasing umbilical flow ratio with gestation. In conclusion, prospective serial study is necessary to test whether measurement of umbilical flow ratios allows monitoring the pump twin's pathophysiologic development, possibly resulting in a guideline for prognosis of pump twin survival. (note)

  8. Identical twins with Alzheimer's disease.

    OpenAIRE

    Kilpatrick, C; Burns, R; Blumbergs, P C

    1983-01-01

    Genetically proven identical twin sisters with Alzheimer's disease are reported. Both sisters at the age of fifty years developed a dementing illness. Their mother and maternal grandmother developed at the same age a similar illness. It is suggested that in some cases of familial Alzheimer's disease the condition is inherited by a single mutant gene.

  9. Register-based research on twins

    DEFF Research Database (Denmark)

    Christensen, Kaare; Ohm Kyvik, Kirsten; Holm, Niels V;

    2011-01-01

    Introduction: The Danish Twin Registry (DTR) has for more than 50 years been based on surveys and clinical investigations and over the two last decades also on register linkage. Currently these two approaches are merged within Statistics Denmark. Research topics: Here we report on three major...... groups of register-based research in the DTR that used the uniqueness of twinning. First, we focus on the ''long-term prognosis'' of being a twin compared with being a singleton and show that Danish twins have health trajectories in adulthood similar to singletons, which is a result of interest for twins...

  10. Fetal growth disorders in twin gestations.

    LENUS (Irish Health Repository)

    Breathnach, Fionnuala M

    2012-06-01

    Twin growth is frequently mismatched. This review serves to explore the pathophysiologic mechanisms that underlie growth aberrations in twin gestations, the prenatal recognition of abnormal twin growth, and the critical importance of stratifying management of abnormal twin growth by chorionicity. Although poor in utero growth of both twins may reflect maternal factors resulting in global uteroplacental dysfunction, discordant twin growth may be attributed to differences in genetic potential between co-twins, placental dysfunction confined to one placenta only, or one placental territory within a shared placenta. In addition, twin-twin transfusion syndrome represents a distinct entity of which discordant growth is a common feature. Discordant growth is recognized as an independent risk factor for adverse perinatal outcome. Intertwin birth weight disparity of 18% or more should be considered to represent a discordance threshold, which serves as an independent risk factor for adverse perinatal outcome. At this cutoff, perinatal morbidity is found to increase both for the larger and the smaller twin within a discordant pair. There remains uncertainty surrounding the sonographic parameters that are most predictive of discordance. Although heightening of fetal surveillance in the face of discordant twin growth follows the principles applied to singleton gestations complicated by fetal growth restriction, the timing of intervention is largely influenced by chorionicity.

  11. TRAP Sequence - An Interesting Entity in Twins

    Directory of Open Access Journals (Sweden)

    R H Srinivas Prasad

    2012-01-01

    Full Text Available Twin reversed arterial perfusion (TRAP sequence, is a rare malformation occurring in monozygotic multiple gestations. One well-developed normal (pump twin and the other twin with absent cardiac structure (acardiac, who is hemodynamically dependent on the normal (pump twin are characteristic of this syndrome. The acardiac twin develops multiple anomalies that make survival difficult. The prognosis of the pump twin is variable with mortality rate ranging from 50% to 70%. Complications that affect the prognosis of the pump twin include complications of congestive cardiac failure due to increased cardiac demand, prematurity secondary to preterm delivery, and polyhydramnios. Because of these complications prompt detection, follow-up, and treatment of this condition is very important. We report two cases of TRAP sequence that emphasizes the importance of gray-scale and color Doppler imaging in diagnosis, detection of poor prognostic features, follow-up, and management of TRAP sequence.

  12. Albumin synthesis in protein energy malnutrition

    International Nuclear Information System (INIS)

    The dietary treatment of protein-energy malnutrition (PEM) has been designed on an empirical basis, with outcomes for successful management including body weight gain and resolution of apathy. We propose using the measurements of protein synthesis as a more objective measure of renourishment. We will therefore randomize a group of malnourished children (weigh-for-height Z score 13C-leucine and serial measurements of 13C-enrichment of albumin. Isotope infusions will be performed on days one and three, following a standard three hour fast. Since albumin synthesis is reduced under the influence of cytokines which mediate the inflammatory response, results will be stratified according to the presence or absence of clinically apparent infections. We hypothesize that the provision of added dietary protein will optimize albumin synthesis rates in PEM as well as attenuate the reduction in albumin synthesis seen in the presence of infections. (author). 20 refs

  13. Paclitaxel Albumin-stabilized Nanoparticle Formulation

    Science.gov (United States)

    This page contains brief information about paclitaxel albumin-stabilized nanoparticle formulation and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.

  14. Profile of total protein, albumin, globulin and albumin globulin ratio in bulls

    Directory of Open Access Journals (Sweden)

    Ida Zahidah Irfan

    2014-06-01

    Full Text Available Determination of serum total protein concentration and main fractions (albumin and globulin can be used as an important diagnostic tool in clinical biochemistry. Several factors can affect the concentration of total protein, albumin, globulin and albumin globulin ratio (A/G. The aim of this study is to obtain serum protein profiles, albumin, globulin and A/G ratio based on breed, age and BCS (body condition score. Blood samples from 160 bulls were collected. Blood chemistry were analyzed by photometer principle using a commercial kit. There were significant (P<0.001 breed variation on total protein, albumin, globulin and albumin globulin ratio. Significant age differences were observed on total protein and albumin concentration (P<0.001, while globulin concentration and A/G ratio were also significant (P<0.05. Amongs groups of BCS, significant difference was verified only in the albumin concentration (P<0.05. The concentration of total proteins, albumins and globulins in the serum of the bulls are higher than standard values for cattle, while A/G ratio is lower.

  15. Bisalbuminemia. A new molecular variant, albumin Vancouver.

    Science.gov (United States)

    Frohlich, J; Kozier, J; Campbell, D J; Curnow, J V; Tárnoky, A L

    1978-11-01

    Of 18 members of a Fiji Indian family investigated, eight of the 12 males and two of the six females had an electrophoretically slow-type bisalbuminemia (alloalbuminemia). The albumin was characterized by the hiterto unique ratio of the two bands (Al A 35%: variant 65%), and by dye-binding studies and electrophoretic mobility in different media. The data suggest that this is a new variant, which we propose to call albumin Vancouver (Al Va).

  16. Renal handling of beta-2-microglobulin, amylase and albumin in acute pancreatitis.

    Science.gov (United States)

    Karlsson, F A; Jacobson, G

    1979-01-01

    The renal handling of beta-2-microglobulin, amylase and albumin was studied in patients with acute pancreatitis. The data were compared with results obtained from patients with glomerular proteinuria and from patients with tubular proteinuria. Initially during acute pancreatitis, the clearance ratio (clearance protein/clearance creatinine) for beta-2-microglobulin was increased dramatically (77-fold) compared to normals. After four to seven days this ratio had fallen and was elevated only 7-fold. The corresponding figures for amylase were 3.3 and 1.8 times and for albumin 9 and 5 times respectively. In glomerular disease, the clearance ratios for beta-2-microglobulin, amylase and albumin were increased 6, 1.1, and 154 times and in tubular disease 448, 1.1, and 28 times, respectively. The electrophoretic pattern of the urinary proteins during pancreatitis was mostly normal. In a few cases, slight tubular proteinuria was noticed. Amylase activity in serum and urine from patients with pancreatitis was found to sediment, (S20,W = 4.6) in a sucrose gradient, identical to amylase from normal serum and urine. The marked increase in the excretion of beta-2-microglobulin probably reflects interference of the kidney function at the proximal tubular level. Determinations of this protein in urine may be of value in studies of kidney dysfunction that can accompany pancreatitis.

  17. Twin Research and the Arts: Interconnections / Twin Research: Twin Studies of Sexual Orientation; A Historical Biological Twin Gem; GWAS Approach to Who Has Twins / Newsworthy: Twins on College Campuses; 'Brainprint': Personal Identification by Brain Waves.

    Science.gov (United States)

    Segal, Nancy L

    2016-08-01

    The interrelatedness between twin research and the arts is explored via a new play about a famous case. In the 1960s, identical twin David Bruce Reimer was accidentally castrated as an infant during circumcision to correct a urinary problem. The decision to raise him as a girl, and the consequences of that decision, are explored in the new theatrical production of Boy. Other examples of the arts mirroring science, and vice versa, are described. Next, brief reviews and summaries of twin research on sexual orientation, 1860s' knowledge of placental arrangements and twinning mechanisms, and genes underlying multiple birth conception and fertility related measures are provided. This article concludes with a look at twins on college campuses and the identification of individuals by their brain waves. A correction and clarification regarding my article on the Brazilian Twin Registry in the last issue of THG (Segal, 2016) is also provided. PMID:27436054

  18. Increased absolute calcium binding to albumin in hypoalbuminaemia.

    OpenAIRE

    Besarab, A; Caro, J F

    1981-01-01

    The amount of calcium bound to protein was measured in 30 patients with differing diseases and varying degrees of hypoalbuminaemia. Total serum calcium increased directly with both serum albumin and ultrafilterable calcium concentrations. The estimated amount of calcium bound per gram of albumin varied inversely with the albumin concentration, decreasing from 2.1 to 1.0 mg calcium/g albumin as albumin concentration increased from 1.7 to 3.1 g/dl. Circulating parathyroid hormone (PTH) concentr...

  19. OPTIMALISASI EKSTRAKSI ALBUMIN IKAN GABUS (Ophiocephalus striatus) SEBAGAI FOOD SUPPLEMENT

    OpenAIRE

    Meta Mahendradatta; Muh. Asfar; Abu Bakar Tawali; Pirman; Nurpuji Astuti; . Suryani

    2013-01-01

    Kandungan albumin yang tinggi pada ikan gabus dan bukti khasiat secara uji klinis terhadap beberapa penyakit, serta mahalnya preparat albumin komersial, membuat ikan gabus menjadi alternative sebagai sumber albumin yang murah. Tujuan penelitian ini adalah untuk mengoptimalisasi proses ekstraksi, pemurnian albumin dari ikan gabus sehingga dapat diperoleh kadar albumin yang lebih tinggi dan dengan khasiat yang lebih baik. Untuk itu perlu diteliti titik isoelektrik untuk mendapatkan ekstrak alb...

  20. Cerebral palsy in the surviving twin associated with infant death of the co-twin

    OpenAIRE

    Pharoah, P.

    2001-01-01

    BACKGROUND—Monozygotic twins are at greater risk of dying and of serious morbidity than dizygotic twins, and both are at greater risk than singletons. This is only partly explained by the higher proportion of low birthweight infants among twins.
AIM—To compare, in same sex and different sex twins, birth weight specific neonatal death rates and cerebral palsy prevalence rates in the surviving twin when the co-twin has died in infancy.
METHODS—Analysis of birth and death...

  1. Nickel Excretion in Urine after Oral Administration

    DEFF Research Database (Denmark)

    Menne, T.; Mikkelsen, H. I.; Solgaard, Per Bent

    1978-01-01

    In recent years the importance of internal exposure to nickel in patients with recurrent hand eczema and nickel allergy has become evident. The present study was performed in order to investigate the value of urinary nickel determinations as an index of oral nickel intake. After oral administration...... of 5.6 mg nickel (as the sulfate), increased nickel excretion was found over the following 2-3 days. We conclude that consecutive urinary nickel determinations are able to disclose variations in oral intake of nickel....

  2. Excretion of Δ9-Tetrahydrocannabinol in Sweat

    OpenAIRE

    Huestis, Marilyn A.; Scheidweiler, Karl B.; Saito, Takeshi; Fortner, Neil; Abraham, Tsadik; Gustafson, Richard A.; Smith, Michael L.

    2007-01-01

    Sweat testing is a noninvasive technique for monitoring drug exposure over a 7-day period in treatment, criminal justice, and employment settings. We evaluated Δ9-tetrahydrocannabinol (THC) excretion in 11 daily cannabis users after cessation of drug use. PharmChek® sweat patches worn for 7 days were analyzed for THC by gas chromatography-mass spectrometry (GC/MS). The limit of quantification (LOQ) for the method was 0.4 ng THC/patch. Sweat patches worn the first week of continuously monitore...

  3. The effect of ACTH upon faecal glucocorticoid excretion in the koala.

    Science.gov (United States)

    Davies, Nicole; Gillett, Amber; McAlpine, Clive; Seabrook, Leonie; Baxter, Greg; Lunney, Daniel; Bradley, Adrian

    2013-10-01

    Environmental changes result in physiological responses of organisms, which can adversely affect population dynamics and reduce resistance to disease. These changes are expressed in chronic levels of stress. The measurement of glucocorticoid (GC) concentrations in faeces is a non-invasive method for monitoring stress in wildlife. The metabolism and excretion of steroids differ significantly between species and, as a consequence, non-invasive methods must be physiologically validated for each species. Koalas (Phascolarctos cinereus) are declining in numbers through much of their range. The role of chronic stress in koala populations has not been identified. Prior to the assessment of faecal GC concentrations in wild koala populations, the excretion timing and concentrations of GCs need to be determined. In this study, we assessed a method for identifying and measuring the concentrations of GC metabolites in faecal pellets of captive koalas following ACTH treatment. The results show that an elevation of plasma cortisol concentrations, using sustained release of ACTH, results in elevated concentrations of faecal cortisol/cortisol metabolites. Taking into account the excretion time lag, an increase in faecal cortisol metabolite concentrations corresponds to the release of GCs from the adrenal cortex as early as 36 h before faecal pellet collection. The calculations of steroid partitioning of plasma cortisol showed that the ACTH-stimulated values were significantly different from the control values for the concentrations of free, corticosteroid-binding globulin-bound and albumin-bound cortisol. This study validates the use of faecal cortisol analysis to assess the activity of the hypothalamo-pituitary-adrenocortical axis in freshly collected koala faecal pellets and indicates that the method should be suitable to assess the adrenocortical status of koalas in wild populations.

  4. Fingerprint recognition with identical twin fingerprints.

    Directory of Open Access Journals (Sweden)

    Xunqiang Tao

    Full Text Available Fingerprint recognition with identical twins is a challenging task due to the closest genetics-based relationship existing in the identical twins. Several pioneers have analyzed the similarity between twins' fingerprints. In this work we continue to investigate the topic of the similarity of identical twin fingerprints. Our study was tested based on a large identical twin fingerprint database that contains 83 twin pairs, 4 fingers per individual and six impressions per finger: 3984 (83*2*4*6 images. Compared to the previous work, our contributions are summarized as follows: (1 Two state-of-the-art fingerprint identification methods: P071 and VeriFinger 6.1 were used, rather than one fingerprint identification method in previous studies. (2 Six impressions per finger were captured, rather than just one impression, which makes the genuine distribution of matching scores more realistic. (3 A larger sample (83 pairs was collected. (4 A novel statistical analysis, which aims at showing the probability distribution of the fingerprint types for the corresponding fingers of identical twins which have same fingerprint type, has been conducted. (5 A novel analysis, which aims at showing which finger from identical twins has higher probability of having same fingerprint type, has been conducted. Our results showed that: (a A state-of-the-art automatic fingerprint verification system can distinguish identical twins without drastic degradation in performance. (b The chance that the fingerprints have the same type from identical twins is 0.7440, comparing to 0.3215 from non-identical twins. (c For the corresponding fingers of identical twins which have same fingerprint type, the probability distribution of five major fingerprint types is similar to the probability distribution for all the fingers' fingerprint type. (d For each of four fingers of identical twins, the probability of having same fingerprint type is similar.

  5. Twin Sessions Through African Eyes

    Institute of Scientific and Technical Information of China (English)

    Ni Yanshuo

    2012-01-01

    Every year journalists from around China and the world flock to Beijing in March to cover the sessions of the National People's Congress (NPC) and the Chinese People's Political Consultative Conference (CPPCC), known as the lianghui, or twin sessions. With the deepening of Sino-African relations in the past decades, an increasing number of African journalists are involved in reporting China's lianghui to their audiences in Africa.

  6. A Little Twin Higgs Model

    OpenAIRE

    Goh, Hock-Seng; Krenke, Christopher A.

    2007-01-01

    We present a twin Higgs model based on left-right symmetry with a tree level quartic. This is made possible by extending the symmetry of the model to include two Z_2 parities, each of which is sufficient to protect the Higgs from getting a quadratically divergent mass squared. Although both parities are broken explicitly, the symmetries that protect the Higgs from getting a quadratically divergent mass are broken only collectively. The quadratic divergences of the Higgs mass are thus still pr...

  7. How albumin administration for cirrhosis impacts on hospital albumin consumption and expenditure

    Institute of Scientific and Technical Information of China (English)

    Federica Mirici-Cappa; Paolo Caraceni; Marco Domenicali; Ernesto Gelonesi; Barbara Benazzi; Giacomo Zaccherini; Franco Trevisani; Cristina Puggioli; Mauro Bernardi

    2011-01-01

    AIM: To assess the impact of guidelines for albumin prescription in an academic hospital, which is a referral center for liver diseases. METHODS: Although randomized trials and guidelines support albumin administration for some complications of cirrhosis, the high cost of albumin greatly limits its use in clinical practice. In 2003, a multidisciplinary panel at Sant'Orsola-Malpighi University Hospital (Bologna, Italy) used a literature-based consensus method to list all the acute and chronic conditions for which albumin is indicated as first- or second-line treatment. Indications in hepatology included prevention of post-paracentesis circulatory dysfunction and renal failure induced by spontaneous bacterial peritonitis, and treatment of hepatorenal syndrome and refractory ascites. Although still debated, albumin administration in refractory ascites is

  8. Potassium excretion during antinatriuresis: perspective from a distal nephron model

    OpenAIRE

    Weinstein, Alan M.

    2011-01-01

    Renal excretion of Na+ and K+ must be regulated independently within the distal nephron, but is complicated by the fact that changing excretion of one solute requires adjustments in the transport of both. It is long known that hypovolemia increases Na+ reabsorption while impairing K+ excretion, even when distal Na+ delivery is little changed. Renewed interest in this micropuncture observation came with identification of the molecular defects underlying familial hyperkalemic hypertension (FHH)...

  9. Lorry drivers' work stress evaluated by catecholamines excreted in urine.

    OpenAIRE

    van der Beek, A J; Meijman, T.F; Frings-Dresen, M. H.; Kuiper, J I; Kuiper, S.

    1995-01-01

    OBJECTIVES--To evaluate lorry drivers' work stress by measurement of adrenaline and noradrenaline excreted in the urine, and to find out which factors in their working situation are related to the excretion rates of these catecholamines. METHODS--The urinary excretion of adrenaline and noradrenaline of 32 lorry drivers, who also had loading and unloading activities to perform, was studied for one working day and one rest day. Each driver was asked to provide six urine samples on both days. RE...

  10. Thrombosis of anastomoses may affect the staging sequence of twin-twin transfusion syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Wijngaard, Jeroen P H M van den; Gemert, Martin J C van [Laser Center, Academic Medical Center-University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam (Netherlands); Ross, Michael G [Department of Obstetrics and Gynecology, Harbor-UCLA School of Medicine, Torrance, CA 90502 (United States)], E-mail: j.p.vandenwijngaard@amc.uva.nl

    2008-03-07

    Twin-twin transfusion syndrome (TTTS) is a severe complication of monozygotic (identical) twins, which share one single monochorionic placenta. It is caused by placental anastomoses which link the two fetoplacental circulations of the twins and allow a chronic net inter-twin transfusion to develop between the fetuses. Clinical presentation of TTTS manifestations has been classified into five different stages. In this paper, we used our computational model of TTTS and examined the possible differences between chronic and rapidly increasing inter-twin transfusion in the simulated TTTS staging sequence. Our results suggest that rapid alterations in the net inter-twin transfusion, e.g. due to thrombosis of placental anastomoses, may produce a different staging sequence than in TTTS caused by chronic inter-twin transfusion. These results may aid an improved knowledge of TTTS pathophysiology under conditions of a rapidly changing cardiovascular function, and contribute to the planning of optimal intervention under such circumstances. (note)

  11. Thrombosis of anastomoses may affect the staging sequence of twin-twin transfusion syndrome

    International Nuclear Information System (INIS)

    Twin-twin transfusion syndrome (TTTS) is a severe complication of monozygotic (identical) twins, which share one single monochorionic placenta. It is caused by placental anastomoses which link the two fetoplacental circulations of the twins and allow a chronic net inter-twin transfusion to develop between the fetuses. Clinical presentation of TTTS manifestations has been classified into five different stages. In this paper, we used our computational model of TTTS and examined the possible differences between chronic and rapidly increasing inter-twin transfusion in the simulated TTTS staging sequence. Our results suggest that rapid alterations in the net inter-twin transfusion, e.g. due to thrombosis of placental anastomoses, may produce a different staging sequence than in TTTS caused by chronic inter-twin transfusion. These results may aid an improved knowledge of TTTS pathophysiology under conditions of a rapidly changing cardiovascular function, and contribute to the planning of optimal intervention under such circumstances. (note)

  12. Macrodeformation Twins in Single-Crystal Aluminum

    Science.gov (United States)

    Zhao, F.; Wang, L.; Fan, D.; Bie, B. X.; Zhou, X. M.; Suo, T.; Li, Y. L.; Chen, M. W.; Liu, C. L.; Qi, M. L.; Zhu, M. H.; Luo, S. N.

    2016-02-01

    Deformation twinning in pure aluminum has been considered to be a unique property of nanostructured aluminum. A lingering mystery is whether deformation twinning occurs in coarse-grained or single-crystal aluminum at scales beyond nanotwins. Here, we present the first experimental demonstration of macrodeformation twins in single-crystal aluminum formed under an ultrahigh strain rate (˜106 s-1 ) and large shear strain (200%) via dynamic equal channel angular pressing. Large-scale molecular dynamics simulations suggest that the frustration of subsonic dislocation motion leads to transonic deformation twinning. Deformation twinning is rooted in the rate dependences of dislocation motion and twinning, which are coupled, complementary processes during severe plastic deformation under ultrahigh strain rates.

  13. Twin-Telescope Wettzell (TTW)

    Science.gov (United States)

    Hase, H.; Dassing, R.; Kronschnabl, G.; Schlüter, W.; Schwarz, W.; Lauber, P.; Kilger, R.

    2007-07-01

    Following the recommendations made by the VLBI2010 vision report of the IVS, a proposal has been made to construct a Twin Telescope for the Fundamental Station Wettzell in order to meet the future requirements of the next VLBI generation. The Twin Telescope consists of two identical radiotelescopes. It is a project of the Federal Agency for Cartography and Geodesy (BKG). This article summarizes the project and some design ideas for the Twin-Telescope. %ZALMA (2005). Technical Specification for Design, Manufacturing, Transport and Integration on Site of the ALMA ANTENNAS, Doc. ALMA-34.00.00.00.006-BSPE. Behrend, D. (2006). VLBI2010 Antenna Specs, Data sheet. DeBoer, D. (2001). The ATA Offset Gregorian Antenna, ATA Memo #16, February 10. Imbriale, W.A. (2006). Design of a Wideband Radio Telescope, Jet Propulsion Laboratory and S. Weinreb and H. Mandi, California Institute of Technology. Kilger, R. (2007). TWIN-Design studies, Presentation for the IVS board members (internal document),Wettzell. Kronschnabl, G. (2006). Subject: Memo from Bill Petrachenko, E-mail to the Twin-Working Group (in German), July. Lindgren, ETS-Lindgren (2005). The Model 3164-05 Open Boundary Quadridge Horn, Data Sheet. Niell, A., A. Whitney, W. Petrachenko, W. Schlüter, N. Vandenberg, H.Hase, Y. Koyama, C. Ma, H. Schuh, G. Tucari (2006). in: IVS Annual Report 2005, pg. 13-40, NASA/TP-2006-214136, April. Olsson, R., Kildal, P.-S., and Weinreb, S. (2006). IEEE Transactions on Antennas and Propagation, Vol. 54, No. 2, February. Petrachenko, B. (2006). The Case For and Against Multiple Antennas at a Site, IVS Memorandum, 2006-019v01. Petrachenko, B. (2006). IVS Memorandum, 2006-016v01. RFSpin (2004). Double Ridged Waveguide Horn-Model DRH20, Antenna Specifications, Data Sheet. Rohde&Schwarz (2004). SHF Antennas Crossed Log- Periodic Antennas HL024A1/S1, Data Sheet. Rohde&Schwarz (2004). SHF Antennas Log-Periodic Antennas HL050/HL050S1, Data Sheet. Rogers, A.E.E. (2006). Simulations of broadband

  14. Modeling single cell antibody excretion on a biosensor.

    Science.gov (United States)

    Stojanović, Ivan; Baumgartner, Wolfgang; van der Velden, Thomas J G; Terstappen, Leon W M M; Schasfoort, Richard B M

    2016-07-01

    We simulated, using Comsol Multiphysics, the excretion of antibodies by single hybridoma cells and their subsequent binding on a surface plasmon resonance imaging (SPRi) sensor. The purpose was to confirm that SPRi is suitable to accurately quantify antibody (anti-EpCAM) excretion. The model showed that antibody loss by diffusion away from the sensor was less than 1%. Unexpectedly, more than 99% of the excreted antibodies were captured on the sensor. These data prove the remarkable phenomenon that the SPRi output of cellular antibody excretion and its subsequent binding, performed under the conditions described here, is directly usable for quantification of single cell antibody production rates. PMID:27040182

  15. The Solar Twin Planet Search II. A Jupiter twin around a solar twin

    CERN Document Server

    Bedell, M; Bean, J L; Ramirez, I; Asplund, M; Alves-Brito, A; Casagrande, L; Dreizler, S; Monroe, T; Spina, L; Maia, M Tucci

    2015-01-01

    Through our HARPS radial velocity survey for planets around solar twin stars, we have identified a promising Jupiter twin candidate around the star HIP11915. We characterize this Keplerian signal and investigate its potential origins in stellar activity. Our analysis indicates that HIP11915 hosts a Jupiter-mass planet with a 3600-day orbital period and low eccentricity. Although we cannot definitively rule out an activity cycle interpretation, we find that a planet interpretation is more likely based on a joint analysis of RV and activity index data. The challenges of long-period radial velocity signals addressed in this paper are critical for the ongoing discovery of Jupiter-like exoplanets. If planetary in nature, the signal investigated here represents a very close analog to the solar system in terms of both Sun-like host star and Jupiter-like planet.

  16. Repression of the albumin gene in Novikoff hepatoma cells

    International Nuclear Information System (INIS)

    Novikoff hepatoma cells have lost their capacity to synthesize albumin. As a first approach to study the mechanisms underlying this event, in vitro translation in a reticulocyte system was performed using total polyadenylated mRNA from rat liver and Novikoff hepatoma cells. Immunoprecipitation of the in vitro translation products with albumin-specific antibody revealed a total lack of albumin synthesis in Novikoff hepatoma, suggesting the absence of functional albumin mRNA in these cells. Titration experiments using as probe albumin cDNA cloned in pBR322 plasmid demonstrated the absence of albumin-specific sequences in both polysomal and nuclear polyadenylated and total RNA from Novikoff cells. This albumin recombinant plasmid was obtained by screening a rat liver cDNA library with albumin [/sup 32/P]cDNA reverse transcribed from immuno-precipitated mRNA. The presence of an albumin-specific gene insert was documented with translation assays as well as by restriction mapping. Repression of the albumin gene at the transcriptional level was further demonstrated by RNA blotting experiments using the cloned albumin cDNA probe. Genomic DNA blots using the cloned albumin cDNA as probe did not reveal any large-scale deletions, insertions, or rearrangements in the albumin gene, suggesting that the processes involved in the suppression of albumin mRNA synthesis do not involve extensive genomic rearrangements

  17. Infantile spasms syndrome in monozygotic twins.

    OpenAIRE

    Pavone, L; Mollica, F; Incorpora, G; Pampiglione, G

    1980-01-01

    The infantile spasms syndrome appeared on the same day in a pair of monozygotic twins at age 6 months. Clinical, electroencephalographic, and neuroradiological findings during the development of the disease are reported. One of the twins was treated with ACTH and in his case clinical and electroencephalographic improvement was more rapid than in the other who was treated with clonazepam. While the computer tomography scan initially showed in each twin an area of low density in the right front...

  18. Anaesthesia for the separation of conjoined twins

    Directory of Open Access Journals (Sweden)

    Jaya Lalwani

    2011-01-01

    Full Text Available Thoraco-omphalopagus is one of the most common type of conjoint twins accounting for 74% cases of conjoint twins. We report the anaesthetic management for successful separation of thoraco-omphalopagus conjoint twins, both of them surviving till date. We highlight the responsibility of anaesthesia team in anaesthetising the two individual patients simultaneously, need of careful monitoring and anticipation of complications like massive blood loss, hypotension, hypokalemia, hypoxia and hypercabia. Detailed description of successful management is reported.

  19. Culture systems: embryo culture and monozygotic twinning.

    Science.gov (United States)

    Sparks, Amy E

    2012-01-01

    The incidence of monozygotic twinning in pregnancies achieved with assisted reproductive technologies (ART) is significantly higher than spontaneously conceived pregnancies. The factors associated with ART that predispose the embryos to splitting are not well-characterized. Assisted hatching and extended embryo culture are two ART laboratory methods that have been risk factors for monozygotic twinning. The methods and strategies that may be employed to avoid monozygotic twinning are discussed in this chapter.

  20. Urticaria in monozygotic and dizygotic twins

    DEFF Research Database (Denmark)

    Thomsen, Simon Francis; van der Sluis, Sophie; Kyvik, Kirsten Ohm;

    2012-01-01

    to atopic diseases. Methods. A total of 256 complete twin pairs and 63 single twins, who were selected from sibships with self-reported asthma via a questionnaire survey of 21,162 adult twins from the Danish Twin Registry, were clinically interviewed about a history of urticaria and examined for atopic...... diseases. Data were analysed with Cox proportional hazards regression and variance components models. Results. A total of 151 individuals (26%) had a history of urticaria, whereas 24 (4%) had had symptoms within the past year. Female sex, HR = 2.09 (1.46-2.99), P = 0.000; hay fever, HR = 1.92 (1...

  1. Myocardial hypertrophy in the recipient with twin-to-twin transfusion syndrome

    DEFF Research Database (Denmark)

    Jeppesen, D.L.; Jorgensen, F.S.; Pryds, O.A.;

    2008-01-01

    In a set of monochorionic-diamniotic twins with twin-to-twin transfusion syndrome, systemic hypertension and biventricular myocardial hypertrophy were found in the recipient. The infant developed mild respiratory distress. A partial exchange transfusion was performed because of polycytaemia. Blood...

  2. Dizygotic monochorionic twin pregnancy conceived following intracytoplasmic sperm injection treatment and complicated by twin-twin transfusion syndrome and blood chimerism

    DEFF Research Database (Denmark)

    Ekelund, C K; Skibsted, L; Søgaard, K;

    2008-01-01

    and zygocity determination were performed on amniotic fluid and showed the twins to be dizygotic with normal female and male karyotypes. There were clinical and sonographic signs of twin-twin transfusion syndrome (TTTS), and Cesarean delivery was performed at 32 weeks' gestation. At birth the twins were...

  3. Can the excretion of metabolites by bacteria be manipulated?

    NARCIS (Netherlands)

    Konings, Wil N.; Poolman, Bert; Driessen, Arnold J.M.

    1992-01-01

    Bacteria can release metabolites into the environment by various mechanisms. Excretion may occur by passive diffusion or by the reversal of the uptake process when the internal concentration of the metabolite exceeds the thermodynamic equilibrium level. In other cases, solutes are excreted against t

  4. Urinary, biliary and faecal excretion of rocuronium in humans

    NARCIS (Netherlands)

    Proost, JH; Eriksson, LI; Mirakhur, RK; Wierda, JMKH

    2000-01-01

    The excretion of rocuronium and its potential metabolites was studied in 38 anaesthetized patients, ASA I-III and 21-69 yr old. Rocuronium bromide was administered as an i.v. bolus dose of 0.3 or 0.9 mg kg(-1). in Part A of the study, the excretion into urine and bile, and the liver content were stu

  5. Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia

    NARCIS (Netherlands)

    El Harchaoui, Karim; Franssen, Remco; Hovingh, G. Kees; Bisoendial, Radjesh J.; Stellaard, Frans; Kuipers, Folkert; Kastelein, John J. P.; Kuivenhoven, Jan Albert; Stroes, Erik S. G.; Groen, Albert K.

    2009-01-01

    BACKGROUND: Fecal bile acid and neutral sterol excretion are the obligate endpoints of the reverse cholesterol transport pathway (RCT). In studies in mice, no evidence was found for a relation between HDL-cholesterol (HDL-c) levels and fecal sterol excretion. In this study, we have evaluated this re

  6. Twin-Foucault imaging method

    Science.gov (United States)

    Harada, Ken

    2012-02-01

    A method of Lorentz electron microscopy, which enables observation two Foucault images simultaneously by using an electron biprism instead of an objective aperture, was developed. The electron biprism is installed between two electron beams deflected by 180° magnetic domains. Potential applied to the biprism deflects the two electron beams further, and two Foucault images with reversed contrast are then obtained in one visual field. The twin Foucault images are able to extract the magnetic domain structures and to reconstruct an ordinary electron micrograph. The developed Foucault method was demonstrated with a 180° domain structure of manganite La0.825Sr0.175MnO3.

  7. Ectodermal dysplasia in identical twins

    Directory of Open Access Journals (Sweden)

    Gurkar Haraswarupa Puttaraju

    2013-01-01

    Full Text Available Hereditary hypohidrotic ectodermal dysplasia (HED is typically inherited as an X-linked recessive trait, characterized by deformity of at least two or more of the ectodermal structures - hair, teeth, nails and sweat glands. Two cases of hereditary HED involving identical male twins, is being documented for the rarity of its occurrence with special attention given to genetics, pathophysiology, clinical, intraoral manifestations and to the methods to improve the masticatory function, the facial esthetics and psychology of patients affected by this disease.

  8. Twin Studies of Atopic Dermatitis

    DEFF Research Database (Denmark)

    Elmose, Camilla; Thomsen, Simon Francis

    2015-01-01

    about filaggrin and its role in the atopic march and provide suggestions for future research in this area. Methods. We identified all twin studies (published after 1970) that have calculated the concordance rate and/or the heritability of AD, or the genetic and environmental correlations between AD and...... around 85% explained by genetic pleiotropy. Conclusions. Genetic factors account for most of the variability in AD susceptibility and for the association between AD and asthma. Controversy remains as to whether the atopic diseases are causally related or whether they are diverse clinical manifestations...

  9. NOTE: Haemodynamic resistance model of monochorionic twin pregnancies complicated by acardiac twinning

    Science.gov (United States)

    Umur, Asli; van Gemert, Martin J. C.; van den Wijngaard, Jeroen P. H. M.; Ross, Michael G.; Nikkels, Peter G. J.

    2004-07-01

    An acardiac twin is a severely malformed monochorionic twin fetus that lacks most organs, particularly a heart. It grows during pregnancy, because it is perfused by its developmentally normal co-twin (called the pump twin) via a set of placental arterioarterial and venovenous anastomoses. The pump twin dies intrauterine or neonatally in about 50% of the cases due to congestive heart failure, polyhydramnios and prematurity. Because the pathophysiology of this pregnancy is currently incompletely understood, we modified our previous haemodynamic model of monochorionic twins connected by placental vascular anastomoses to include the analysis of acardiac twin pregnancies. We incorporated the fetoplacental circulation as a resistance circuit and used the fetal umbilical flow that perfuses the body to define fetal growth, rather than the placental flow as done previously. Using this modified model, we predicted that the pump twin has excess blood volume and increased mean arterial blood pressure compared to those in the acardiac twin. Placental perfusion of the acardiac twin is significantly reduced compared to normal, as a consequence of an increased venous pressure, possibly implying reduced acardiac placental growth. In conclusion, the haemodynamic analysis may contribute to an increased knowledge of the pathophysiologic consequences of an acardiac body mass for the pump twin.

  10. Haemodynamic resistance model of monochorionic twin pregnancies complicated by acardiac twinning

    International Nuclear Information System (INIS)

    An acardiac twin is a severely malformed monochorionic twin fetus that lacks most organs, particularly a heart. It grows during pregnancy, because it is perfused by its developmentally normal co-twin (called the pump twin) via a set of placental arterioarterial and venovenous anastomoses. The pump twin dies intrauterine or neonatally in about 50% of the cases due to congestive heart failure, polyhydramnios and prematurity. Because the pathophysiology of this pregnancy is currently incompletely understood, we modified our previous haemodynamic model of monochorionic twins connected by placental vascular anastomoses to include the analysis of acardiac twin pregnancies. We incorporated the fetoplacental circulation as a resistance circuit and used the fetal umbilical flow that perfuses the body to define fetal growth, rather than the placental flow as done previously. Using this modified model, we predicted that the pump twin has excess blood volume and increased mean arterial blood pressure compared to those in the acardiac twin. Placental perfusion of the acardiac twin is significantly reduced compared to normal, as a consequence of an increased venous pressure, possibly implying reduced acardiac placental growth. In conclusion, the haemodynamic analysis may contribute to an increased knowledge of the pathophysiologic consequences of an acardiac body mass for the pump twin. (note)

  11. Haemodynamic resistance model of monochorionic twin pregnancies complicated by acardiac twinning

    Energy Technology Data Exchange (ETDEWEB)

    Umur, Asli [Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam(Netherlands); Gemert, Martin J C van [Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands); Wijngaard, Jeroen P H M van den [Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands); Ross, Michael G [Department of Obstetrics and Gynecology, Harbor University of California-Los Angeles Medical Center, Torrence, CA 9050 (United States); Nikkels, Peter G J [Department of Pathology, University Medical Center, Utrecht (Netherlands)

    2004-07-21

    An acardiac twin is a severely malformed monochorionic twin fetus that lacks most organs, particularly a heart. It grows during pregnancy, because it is perfused by its developmentally normal co-twin (called the pump twin) via a set of placental arterioarterial and venovenous anastomoses. The pump twin dies intrauterine or neonatally in about 50% of the cases due to congestive heart failure, polyhydramnios and prematurity. Because the pathophysiology of this pregnancy is currently incompletely understood, we modified our previous haemodynamic model of monochorionic twins connected by placental vascular anastomoses to include the analysis of acardiac twin pregnancies. We incorporated the fetoplacental circulation as a resistance circuit and used the fetal umbilical flow that perfuses the body to define fetal growth, rather than the placental flow as done previously. Using this modified model, we predicted that the pump twin has excess blood volume and increased mean arterial blood pressure compared to those in the acardiac twin. Placental perfusion of the acardiac twin is significantly reduced compared to normal, as a consequence of an increased venous pressure, possibly implying reduced acardiac placental growth. In conclusion, the haemodynamic analysis may contribute to an increased knowledge of the pathophysiologic consequences of an acardiac body mass for the pump twin. (note)

  12. Bidirectional peritoneal transport of albumin in continuous ambulatory peritoneal dialysis

    DEFF Research Database (Denmark)

    Joffe, P; Henriksen, Jens Henrik Sahl

    1995-01-01

    The present study was undertaken in order to assess bidirectional peritoneal kinetics of albumin after simultaneous i.v. and i.p. injection of radioiodinated albumin tracers (125I-RISA and 131I-RISA) in eight clinically stable uraemic patients undergoing continuous ambulatory peritoneal dialysis...... (CAPD). The plasma volume, intravascular albumin mass (IVM), and overall extravasation rate of albumin were not significantly different from that found in healthy controls. Albumin flux from the plasma into the peritoneal cavity was 3.71 +/- 0.82 (SD) mumol/h, which was only 3% of the overall...... extravasation rate (137 +/- 52 mumol/h). Albumin flux from the peritoneal cavity into the plasma was substantially lower (0.22 +/- 0.07 mumol/h, P peritoneal accumulation of the albumin from plasma over 4 h was 14 +/- 3.2 mumol, which was significantly lower than the intraperitoneal albumin...

  13. Comparison of antioxidant properties of different therapeutic albumin preparations.

    Science.gov (United States)

    Plantier, Jean-Luc; Duretz, Véronique; Devos, Véronique; Urbain, Rémi; Jorieux, Sylvie

    2016-07-01

    Albumin displays several important functions for homeostasis amongst which the maintenance of the plasma redox-state. The study aim was to compare the redox state of pharmaceutical human albumin preparations since it reflects the oxidation-reduction status of the surrounding environment. Using an array of analytical methods, four commercially available albumins were compared with respect to their structural characteristics (cobalt ion binding, glycation, spectrophotometric and fluorometric profiles) and their ability to scavenge hydroxyl, peroxyl or free radicals. The different albumins exhibited a similar structural profile as well as hydroxyl and peroxyl scavenging activities. By contrast, the albumin from LFB (Vialebex(®)) possessed a significantly higher capacity to transfer electrons to DPPH, as compared with other albumins that was correlated with the level of free cysteine-34. Commercially available albumins differed for some of their antioxidant properties. The albumin preparation possessing the highest level of free cysteine-34 exhibited the highest antioxidant potential. PMID:27156143

  14. Association Between Sodium Intake and Change in Uric Acid, Urine Albumin Excretion, and the Risk of Developing Hypertension

    NARCIS (Netherlands)

    Forman, John P.; Scheven, Lieneke; de Jong, Paul E.; Bakker, Stephan J. L.; Curhan, Gary C.; Gansevoort, Ron T.

    2012-01-01

    Background-A high-sodium diet has little short-term effect on blood pressure in nonhypertensive individuals but, for unclear reasons, is associated with hypertension if consumed long term. We hypothesized that a chronically high sodium intake would be associated with increases in biomarkers of endot

  15. Vitamin D levels and asymptomatic coronary artery disease in type 2 diabetic patients with elevated urinary albumin excretion rate

    DEFF Research Database (Denmark)

    Joergensen, Christel; Reinhard, Henrik; Schmedes, Anne;

    2012-01-01

    Coronary artery disease (CAD) is the major cause of morbidity and mortality in type 2 diabetic patients. Severe vitamin D deficiency has been shown to predict cardiovascular mortality in type 2 diabetic patients.......Coronary artery disease (CAD) is the major cause of morbidity and mortality in type 2 diabetic patients. Severe vitamin D deficiency has been shown to predict cardiovascular mortality in type 2 diabetic patients....

  16. Ionospheric Response to Traveling Convection Twin Vortices

    OpenAIRE

    Schunk, Robert W.; Zhu, Lie; Sojka, Jan Josef

    1994-01-01

    Traveling convection twin vortices have been observed for several years. At ionospheric altitudes, the twin vortices correspond to spatially localized, transient structures embedded in a large‐scale background convection pattern. The convection vortices are typically observed in the morning and evening regions. They are aligned predominantly in the east‐west direction and have a horizontal extent of from 500–1000 km....

  17. Twin-Screw Extruders in Ceramic Extrusion

    Science.gov (United States)

    Wiedmann, Werner; Hölzel, Maria

    The machines mainly used for compounding plastics, chemicals and food are co-rotating, closely intermeshing twin-screw extruders. Some 30 000 such extruders are in use worldwide, about 1/3 are ZSKs from Coperion Werner & Pfleiderer, Stuttgart. In the chemical industry more and more batch mixers are being replaced by continuous twin-screw kneaders.

  18. Strong crystal size effect on deformation twinning

    DEFF Research Database (Denmark)

    Yu, Qian; Shan, Zhi-Wei; Li, Ju;

    2010-01-01

    find that the stress required for deformation twinning increases drastically with decreasing sample size of a titanium alloy single crystal7, 8, until the sample size is reduced to one micrometre, below which the deformation twinning is entirely replaced by less correlated, ordinary dislocation...

  19. Structural basis of transport of lysophospholipids by human serum albumin

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shihui; Shi, Xiaoli; Yang, Feng; Chen, Liqing; Meehan, Edward J.; Bian, Chuanbing; Huang, Mingdong; (UAH); (Chinese Aca. Sci.)

    2010-10-08

    Lysophospholipids play important roles in cellular signal transduction and are implicated in many biological processes, including tumorigenesis, angiogenesis, immunity, atherosclerosis, arteriosclerosis, cancer and neuronal survival. The intracellular transport of lysophospholipids is through FA (fatty acid)-binding protein. Lysophospholipids are also found in the extracellular space. However, the transport mechanism of lysophospholipids in the extracellular space is unknown. HSA (human serum albumin) is the most abundant carrier protein in blood plasma and plays an important role in determining the absorption, distribution, metabolism and excretion of drugs. In the present study, LPE (lysophosphatidylethanolamine) was used as the ligand to analyse the interaction of lysophospholipids with HSA by fluorescence quenching and crystallography. Fluorescence measurement showed that LPE binds to HSA with a K{sub d} (dissociation constant) of 5.6 {micro}M. The presence of FA (myristate) decreases this binding affinity (K{sub d} of 12.9 {micro}M). Moreover, we determined the crystal structure of HSA in complex with both myristate and LPE and showed that LPE binds at Sudlow site I located in subdomain IIA. LPE occupies two of the three subsites in Sudlow site I, with the LPE acyl chain occupying the hydrophobic bottom of Sudlow site I and the polar head group located at Sudlow site I entrance region pointing to the solvent. This orientation of LPE in HSA suggests that HSA is capable of accommodating other lysophospholipids and phospholipids. The study provides structural information on HSA-lysophospholipid interaction and may facilitate our understanding of the transport and distribution of lysophospholipids.

  20. Utilizing twins as controls for non-twin case-materials in genome wide association studies.

    Directory of Open Access Journals (Sweden)

    Andrea Ganna

    Full Text Available Twin registries around the globe have collected DNA samples from large numbers of monozygotic and dizygotic twins. The twin sample collections are frequently used as controls in disease-specific studies together with non-twins. This approach is unbiased under the hypothesis that twins and singletons are comparable in terms of allele frequencies; i.e. there are no genetic variants associated with being a twin per se. To test this hypothesis we performed a genome-wide association study comparing the allele frequency of 572,352 single nucleotide polymorphisms (SNPs in 1,413 monozygotic (MZ and 5,451 dizygotic (DZ twins with 3,720 healthy singletons. Twins and singletons have been genotyped using the same platform. SNPs showing association with being a twin at P-value < 1 × 10(-5 were selected for replication analysis in 1,492 twins (463 MZ and 1,029 DZ and 1,880 singletons from Finland. No SNPs reached genome-wide significance (P-value < 5 × 10(-8 in the main analysis combining MZ and DZ twins. In a secondary analysis including only DZ twins two SNPs (rs2033541 close to ADAMTSL1 and rs4149283 close to ABCA1 were genome-wide significant after meta-analysis with the Finnish population. The estimated proportion of variance on the liability scale explained by all SNPs was 0.08 (P-value=0.003 when MZ and DZ were considered together and smaller for MZ (0.06, P-value=0.10 compared to DZ (0.09, P-value=0.003 when analyzed separately. In conclusion, twins and singletons can be used in genetic studies together with general population samples without introducing large bias. Further research is needed to explore genetic variances associated with DZ twinning.

  1. Repression of the albumin gene in Novikoff hepatoma cells.

    OpenAIRE

    Capetanaki, Y G; Flytzanis, C N; Alonso, A

    1982-01-01

    Novikoff hepatoma cells have lost their capacity to synthesize albumin. As a first approach to study the mechanisms underlying this event, in vitro translation in a reticulocyte system was performed using total polyadenylated mRNA from rat liver and Novikoff hepatoma cells. Immunoprecipitation of the in vitro translation products with albumin-specific antibody revealed a total lack of albumin synthesis in Novikoff hepatoma, suggesting the absence of functional albumin mRNA in these cells. Tit...

  2. Mechanisms of Glomerular Albumin Filtration and Tubular Reabsorption

    OpenAIRE

    Satoshi Kinugasa; Akihiro Tojo

    2012-01-01

    Albumin is filtered through the glomerulus with a sieving coefficient of 0.00062, which results in approximately 3.3 g of albumin filtered daily in human kidneys. The proximal convoluted tubule reabsorbs 71%, the loop of Henle and distal tubule 23%, and collecting duct 3% of the glomerular filtered albumin, thus indicating that the kidney plays an important role in protein metabolism. Dysfunction of albumin reabsorption in the proximal tubules, due to reduced megalin expression, may explain t...

  3. Twins in Ancient Greece: a synopsis.

    Science.gov (United States)

    Malamitsi-Puchner, Ariadne

    2016-01-01

    This brief outline associates twins with several aspects of life in Ancient Greece. In Greek mythology twins caused ambivalent reactions and were believed to have ambivalent feelings for each other. Very often, they were viewed as the representatives of the dualistic nature of the universe. Heteropaternal superfecundation, which dominates in ancient myths, explains on one hand, the god-like qualities and, on the other hand, the mortal nature of many twins. An assumption is presented that legends referring to twins might reflect the territorial expansions of Ancient Greeks in Northern Mediterranean, around the Black Sea, in Asia Minor, as well as North East Africa. In conclusion, in Greek antiquity, twins have been used as transitional figures between myth and reality. PMID:26135766

  4. Intrafetal alcohol ablation of an acardiac twin

    Directory of Open Access Journals (Sweden)

    Zahar Azuar Zakaria

    2016-07-01

    Full Text Available The twin reverse arterial perfusion (TRAP sequence is a rare but serious complication of mono-chorionic multiple pregnancies in which the affected twin is reversely perfused from the healthy co-twin. The unaffected twin is at risk of cardiac de-compensation or complication related to polyhydramnios, preterm pre-labour rupture of membrane and preterm delivery. When the risk to the healthy fetus increases significantly, the management is to occlude the circulation to the acardiac twin. Here we report a case successfully managed with intra-fetal alcohol ablation at the mid-trimester. [Int J Reprod Contracept Obstet Gynecol 2016; 5(7.000: 2421-2424

  5. 99mTc-albumin can replace 125I-albumin to determine plasma volume repeatedly

    DEFF Research Database (Denmark)

    Bonfils, Peter K; Damgaard, Morten; Stokholm, Knud H;

    2012-01-01

    OBJECTIVE: Plasma volume assessment may be of importance in several disorders. The purpose of the present study was to compare the reliability of plasma volume measurements by technetium-labeled human serum albumin ((99m)Tc-HSA) with a simultaneously performed plasma volume determination with...... iodine-labeled human serum albumin ((125)I-HSA). MATERIALS AND METHODS: In 15 healthy volunteers, simultaneous plasma volume measurements with (99m)Tc-HSA and (125)I-HSA were performed after ½ hour in the supine position. Blood samples were obtained 10, 15, 20, and 30 minutes after the injection for...... accurate retropolation from the plasma counts to time zero to correct for leakage of the isotopes from the circulation. RESULTS: The mean difference (bias) between plasma volume measured with (125)I-albumin and (99m)Tc-albumin was 8 ml (0.1 ml/kg) with limits of agreement (bias ±1.96 SD) ranging from -181...

  6. Micropinocytic Ingestion of Glycosylated Albumin by Isolated Microvessels: Possible Role in Pathogenesis of Diabetic Microangiopathy

    Science.gov (United States)

    Williams, Stuart K.; Devenny, James J.; Bitensky, Mark W.

    1981-04-01

    Microvessels isolated from rat epididymal fat exhibit differential vesicular ingestion rates for unmodified and nonenzymatically glycosylated rat albumin. While unmodified rat albumin is excluded from ingestion by endothelial micropinocytic vesicles, glycosylated albumin is avidly taken up by endocytosis. Interaction of albumin and glycosylated albumin with endothelium was studied with a double-label fluorescence assay of micropinocytosis. When glycosylated albumin was present at a concentration of 6% with respect to total albumin (the level found in ``non diabetic'' serum), only glycosylated albumin was ingested. At higher concentrations of glycosylated albumin (those found in diabetic serum), both albumin and glycosylated albumin are ingested. Glycosylation of endothelial membrane components results in stimulated ingestion of glycosylated albumin, persistent exclusion of unmodified albumin, and unaltered micropinocytic ingestion of native ferritin. These results indicate that nonenzymatic glycosylation of serum albumin may result in rapid vesicle-mediated extravasation of albumin. Chronic microvascular leakage of glycosylated albumin could contribute to the pathogenesis of diabetic microangiopathy.

  7. 21 CFR 866.5040 - Albumin immunological test system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Albumin immunological test system. 866.5040... (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological Test Systems § 866.5040 Albumin immunological test system. (a) Identification. An albumin immunological test system is a device that consists...

  8. Drug Delivery Vehicles Based on Albumin-Polymer Conjugates.

    Science.gov (United States)

    Jiang, Yanyan; Stenzel, Martina

    2016-06-01

    Albumin has been a popular building block to create nanoparticles for drug delivery purposes. The performance of albumin as a drug carrier can be enhanced by combining protein with polymers, which allows the design of carriers to encompass a broader spectrum of drugs while features unique to synthetic polymers such as stimuli-responsiveness are introduced. Nanoparticles based on polymer-albumin hybrids can be divided into two classes: one that carries album as a bioactive surface coating and the other that uses albumin as biocompatible, although nonbioactive, building block. Nanoparticles with bioactive albumin surface coating can either be prepared by self-assembly of albumin-polymer conjugates or by postcoating of existing nanoparticles with albumin. Albumin has also been used as building block, either in its native or denatured form. Existing albumin nanoparticles are coated with polymers, which can influence the degradation of albumin or impact on the drug release. Finally, an alternative way of using albumin by denaturing the protein to generate a highly functional chain, which can be modified with polymer, has been presented. These albumin nanoparticles are designed to be extremely versatile so that they can deliver a wide variety of drugs, including traditional hydrophobic drugs, metal-based drugs and even therapeutic proteins and siRNA. PMID:26947019

  9. Drug Delivery Vehicles Based on Albumin-Polymer Conjugates.

    Science.gov (United States)

    Jiang, Yanyan; Stenzel, Martina

    2016-06-01

    Albumin has been a popular building block to create nanoparticles for drug delivery purposes. The performance of albumin as a drug carrier can be enhanced by combining protein with polymers, which allows the design of carriers to encompass a broader spectrum of drugs while features unique to synthetic polymers such as stimuli-responsiveness are introduced. Nanoparticles based on polymer-albumin hybrids can be divided into two classes: one that carries album as a bioactive surface coating and the other that uses albumin as biocompatible, although nonbioactive, building block. Nanoparticles with bioactive albumin surface coating can either be prepared by self-assembly of albumin-polymer conjugates or by postcoating of existing nanoparticles with albumin. Albumin has also been used as building block, either in its native or denatured form. Existing albumin nanoparticles are coated with polymers, which can influence the degradation of albumin or impact on the drug release. Finally, an alternative way of using albumin by denaturing the protein to generate a highly functional chain, which can be modified with polymer, has been presented. These albumin nanoparticles are designed to be extremely versatile so that they can deliver a wide variety of drugs, including traditional hydrophobic drugs, metal-based drugs and even therapeutic proteins and siRNA.

  10. Surface receptors for serum albumin in group C and G streptococci show three different types of albumin specificity.

    OpenAIRE

    Wideback, K; Kronvall, G

    1982-01-01

    A total of 100 bacterial strains were tested for binding uptake of radiolabeled albumin preparations from 15 mammalian species. Three types of surface structures with specific binding sites for albumin were defined. A previously described receptor for albumin was separated into type a in Streptococcus equisimilis strains and in human group G streptococcal strains and type b in bovine group C streptococci. A new type of albumin receptor, type c, was found in Streptococcus dysgalactiae strains,...

  11. Novel Role for Albumin in Innate Immunity: Serum Albumin Inhibits the Growth of Blastomyces dermatitidis Yeast Form In Vitro

    OpenAIRE

    Giles, Steven; Czuprynski, Charles

    2003-01-01

    In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored inhibitory activity. Inhibitory activity does not require albumin domain III and appears to involve binding of a low-molecular-weight yeast-derived growth factor.

  12. Studies on kinetics of albumin in uraemic patients on chronic haemodialysis: evidence of interstitial albumin wash-down

    DEFF Research Database (Denmark)

    Hildebrandt, P; Jensen, H A; Henriksen, Jens Henrik Sahl

    1983-01-01

    Albumin-kinetic studies were performed in nine uraemic patients without oedema on chronic haemodialysis and in seven normal controls in order to determine microvascular leakiness and thereby, during steady state, lymph drainage of albumin. Transvascular escape rate of albumin [TERalb i.e. the fra...... considered to be in steady state during the measurements, the increased TERalb indicates increased lymph flux of albumin. The interstitial space protein 'wash-down' and increased lymph drainage probably serve as oedema prevention....

  13. Modelling the influence of amnionicity on the severity of twin-twin transfusion syndrome in monochorionic twin pregnancies

    Energy Technology Data Exchange (ETDEWEB)

    Wijngaard, Jeroen P H M van den [Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands); Umur, Asli [Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands); Ross, Michael G [Department of Obstetrics and Gynecology, Harbor University of California-Los Angeles Medical Center, Torrance, CA 90502 (United States); Gemert, Martin J C van [Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands)

    2004-03-21

    Clinical treatment for diamniotic-monochorionic twin-twin transfusion syndrome (TTTS) may include conversion of diamniotic pregnancies to a monoamniotic-monochorionic state by disrupting the amnion septum. We sought to test the underlying hypothesis, i.e. that a monoamniotic state reduces the severity of TTTS. With use of our previously developed mathematical model of two equal fetoplacental circulatory units connected by various sizes and types of placental anastomoses, we compared the haemodynamic and amniotic fluid dynamics of monoamniotic and diamniotic twins that develop TTTS. We used three anastomotic patterns that produce severe, moderate or mild forms of TTTS, respectively, in our diamniotic-monochorionic twin model. Monoamnionicity was modelled by adding the two amniotic fluid volumes and using the volume-averaged amniotic fluid osmolality. The results were as follows: for severe TTTS, small differences develop between diamniotic and monoamniotic donor twins in fetal urine production, swallowed volume, blood volume, blood pressures, net fetofetal transfusion, and blood and amniotic fluid osmolality. However, the circulatory imbalance between the monoamniotic twins deteriorates similar to that of diamniotic twins. The pathophysiological differences tend to disappear for milder TTTS. In conclusion, our model suggests that the uncommon finding of TTTS in monoamniotic twins is not due to the presence of a single amniotic sac. Rather, clinically significant differences in anastomotic patterns and the delayed or lack of identification of manifestations in monoamniotic twins account for the reduced rate of TTTS diagnosis. Based on these results we expect the clinical disruption of the amnion septum in diamniotic-monochorionic TTTS pregnancies to have only minimal benefits. (note)

  14. NOTE: Thrombosis of anastomoses may affect the staging sequence of twin twin transfusion syndrome

    Science.gov (United States)

    van den Wijngaard, Jeroen P. H. M.; Ross, Michael G.; van Gemert, Martin J. C.

    2008-03-01

    Twin-twin transfusion syndrome (TTTS) is a severe complication of monozygotic (identical) twins, which share one single monochorionic placenta. It is caused by placental anastomoses which link the two fetoplacental circulations of the twins and allow a chronic net inter-twin transfusion to develop between the fetuses. Clinical presentation of TTTS manifestations has been classified into five different stages. In this paper, we used our computational model of TTTS and examined the possible differences between chronic and rapidly increasing inter-twin transfusion in the simulated TTTS staging sequence. Our results suggest that rapid alterations in the net inter-twin transfusion, e.g. due to thrombosis of placental anastomoses, may produce a different staging sequence than in TTTS caused by chronic inter-twin transfusion. These results may aid an improved knowledge of TTTS pathophysiology under conditions of a rapidly changing cardiovascular function, and contribute to the planning of optimal intervention under such circumstances. Supported in part by the European Community Euro-twin-2-twin project (JPHMvdW) and by the National Institutes of Health, grant HL40899 (MGR).

  15. Excretion of biliary compounds during intrauterine life

    Science.gov (United States)

    Macias, Rocio IR; Marin, Jose JG; Serrano, Maria A

    2009-01-01

    In adults, the hepatobiliary system, together with the kidney, constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine, respectively. However, during intrauterine life the biliary route of excretion for cholephilic compounds, such as bile acids and biliary pigments, is very poor. Although very early in pregnancy the fetal liver produces bile acids, bilirubin and biliverdin, these compounds cannot be efficiently eliminated by the fetal hepatobiliary system, owing to the immaturity of the excretory machinery in the fetal liver. Therefore, the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta. Owing to the presence of detoxifying enzymes and specific transport systems at different locations of the placental barrier, such as the endothelial cells of chorionic vessels and trophoblast cells, this organ plays an important role in the hepatobiliary-like function during intrauterine life. The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother. This may result in oxidative stress and apoptosis, mainly in the placenta and fetal liver, which might affect normal fetal development and challenge the fate of the pregnancy. The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem. PMID:19230042

  16. Excretion of drugs in human breast milk

    Energy Technology Data Exchange (ETDEWEB)

    Welch, R.M.; Findlay, J.W.

    1981-01-01

    The present report briefly discusses some of the morphological, physiological, and compositional aspects of animal and human breast milk and how these characteristics might be important for the accumulation of drugs and foreign compounds. In addition, a study is described confirming the presence of caffeine, codeine, morphine, phenacetin, acetaminophen, and salicylic acid in the breast milk of a lactating mother following oral administration of a combination analgesic containing aspirin, phenacetin, caffeine, and codeine. Although the study is limited to one subject, it has provided critically needed data on the rates of appearance in, and elimination of these drugs from, breast milk. A similar amount of information is presented on phenacetin, also a component of the analgesic mixture, which has not been previously reported to enter human milk. The distribution of these drugs between the slightly more acidic breast milk and the relatively neutral plasma is consistent with their weakly basic, acidic, or relatively neutral properties. In general, the study shows that codeine and morphine milk concentrations are higher than, salicylic acid milk levels are much lower than, and phenacetin, caffeine, and acetaminophen milk concentrations are relatively similar to their respective plasma levels. It is projected, from estimated steady-state milk concentrations of the drugs and their metabolites studied, that very low percentages of the therapeutic dosages (less than 0.7%) would be excreted in mother's milk, too low an amount to be clinically significant to the infant.

  17. Excretion of biliary compounds during intrauterine life

    Institute of Scientific and Technical Information of China (English)

    Rocio IR Macias; Jose JG Marin; Maria A Serrano

    2009-01-01

    In adults, the hepatobiliary system, together with thekidney, constitute the main routes for the eliminationof several endogenous and xenobiotic compounds intobile and urine, respectively. However, during intrauterinelife the biliary route of excretion for cholephiliccompounds, such as bile acids and biliary pigments, isvery poor. Although very early in pregnancy the fetal liver produces bile acids, bilirubin and biliverdin, these compounds cannot be efficiently eliminated by the fetal hepatobiliary system, owing to the immaturity of the excretory machinery in the fetal liver. Therefore, the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta. Owing to the presence of detoxifying enzymes and specific transport systems at different locations of the placental barrier, such as the endothelial cells of chorionic vessels and trophoblast cells, this organ plays an important role in the hepatobiliary-like function during intrauterine life. The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother. This may result in oxidative stress and apoptosis, mainly in the placenta and fetal liver, which might affect normal fetal development and challenge the fate of the pregnancy. The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem.

  18. Urinary growth hormone excretion in 657 healthy children and adults

    DEFF Research Database (Denmark)

    Main, K; Philips, M; Jørgensen, M;

    1991-01-01

    Urinary growth hormone (u-GH) excretion was measured in 547 healthy children and 110 adults by ELISA with a detection limit of 1.1 ng/l u-GH after prior concentration of the urine samples (20- to 30-fold). u-GH excretion values were significantly dependent on the pubertal stage (p less than 0.......0001) with maximum values in Tanner stage 3 for girls and 4 for boys. This corresponded to a peak in u-GH excretion between 11.5-14.5 years in girls and 12.5-16 years in boys. Additionally, u-GH excretion in adults was significantly higher than in prepubertal children (p less than 0.001). The day/night ratio...... of u-GH excretion (pg/h) was significantly higher in females than in males (p less than 0.01). In Tanner stages 1-4, u-GH excretion during the day was lower than that at night, whereas the opposite was true in late puberty and in adult women. The interindividual variation of u-GH excretion within the...

  19. Distribution and degradation of albumin in extensive skin disease

    DEFF Research Database (Denmark)

    Worm, Anne-Marie; Taaning, E; Rossing, N;

    1981-01-01

    The distribution and degradation of albumin were determined in twelve patients with extensive skin disease and in ten control subjects by measuring the metabolic turnover and transcapillary escape of 132 I-labelled albumin. The ratio of intravascular to total mass of albumin was normal. Thus...... in the patients than in the controls (P less than 0.001). It is concluded that the hypoalbuminaemia in these patients is the result of an increased endogenous catabolism of albumin without significant loss via urine, stools or skin. A positive correlation between the transcapillary escape rate and fractional...... catabolic rate of albumin supports the concept of a causal relationship between these parameters....

  20. A Twin Study of Perthes Disease

    DEFF Research Database (Denmark)

    Metcalfe, David; Van Dijck, Stephanie; Parsons, Nicolas;

    2016-01-01

    was calculated to describe the likelihood that any given individual had LCPD if their co-twin was also diagnosed. RESULTS: There were 81 twin pairs: 10 monozygotic, 51 dizygotic, and 20 unclassified (unknown zygosity [UZ]). There was no association between birth weight and being the affected co-twin. Four pairs...... (2 dizygotic and 2 UZ) were concordant for LCPD, which is greater than would be expected assuming no familial aggregation. There were no concordant monozygotic twin pairs. The overall probandwise concordance was 0.09 (95% confidence interval [CI]: 0.01-0.18): 0.00 for the monozygotic, 0.08 (95% CI: 0.......00-0.18) for the dizygotic, and 0.18 (95% CI: 0.00-0.40) for the UZ twin pairs. CONCLUSIONS: This study found evidence of familial clustering in LCPD but did not show a genetic component. The absolute risk that a co-twin of an affected individual will develop LCPD is low, even in the case of monozygotic twin pairs....

  1. Mechanical twinning in small quartz crystals

    Science.gov (United States)

    Laughner, J. W.; Newnham, R. E.; Cross, L. E.

    1982-02-01

    Quartz is known to be ferrobielastic; that is, quartz crystals have domain states (Dauphiné twins) which differ in their elastic compliance values and which can be switched by an appropriately oriented stress. Polycrystalline quartz has also been reported (Tullis 1970) to show preferential orientation of these domains following application of large uniaxial stresses. These experiments were designed to study twinning of synthetic quartz “grains” (minimum size 0.07×0.07×0.02 cm) in specially-constructed composites and of grains in three natural quartz aggregates — a quartzite, a novaculite, and a jasper. Backreflection X-ray techniques were used to verify twinning in the composite grains, while special electroding and electrical detection allowed the twinning processes to be examined in “real time.” Small synthetic quartz crystals were found to behave identically to the massive samples previously studied. Electrical pulses due to the reversal of piezoelectric coefficient d 11 in twinned quartz were detected from quartzite and from the man-made composites. Novaculite also gave electrical pulses which were probably from twinning (evidenced by the correlation of expected and observed pulse sizes and shapes), while no pulses from the jaspers indicative of twinning were detected. Grain size distribution differences are considered the main structural reason for the different behaviors.

  2. Dietary intake and urinary excretion of lignans in Finnish men

    DEFF Research Database (Denmark)

    Nurmi, Tarja; Mursu, Jaakko; Peñalvo, José L;

    2010-01-01

    Intake of lignans has been assessed in different study populations, but so far none of the studies has compared the daily intake of lignans and the urinary excretion of plant and enterolignans. We assessed the intake of lariciresinol, pinoresinol, secoisolariciresinol and matairesinol in 100....../d, of which lariciresinol and pinoresinol covered 78 %. Almost half (47 %) of the intake of lignans was explained by the intake of rye products, berries, coffee, tea and roots. The urinary excretion of plant lignans corresponded to 17 % and enterolignans to 92 % of the intake of lignans. The urinary excretion...

  3. Monozygotic twins with trisomy 18: a report of discordant phenotype.

    OpenAIRE

    Schlessel, J S; Brown, W T; Lysikiewicz, A.; Schiff, R.; Zaslav, A L

    1990-01-01

    The predicted incidence of liveborn monozygotic trisomy 18 twins is one per million births. The first case of liveborn monozygotic trisomy 18 twins was reported in 1989 and we report a second case in which striking phenotypic discordance existed. The probability of monozygotic trisomy 18 twinning and the mechanisms for phenotypic discordance in trisomic twins is discussed.

  4. Langevin's `Twin Paradox' paper revisited

    CERN Document Server

    Field, J H

    2008-01-01

    An in-depth and mathematically-detailed analysis of Langevin's popular 1911 article on the special theory of relativity is presented. For the reader's convenience, English translations of large parts of the original French text are given. The self-contradictory nature of many of Langevin's assertions is pointed out. Of special interest is the analysis of the exchange of light signals between the travelling and stay-at-home twins in Langevin's thought experiment, in which antinomies are found in the conventional relativistic treatment. Their resolution shows that the physical basis of the differential aging effect in the experiment is not `length contraction', as in the conventional interpretation, but instead the application of the correct relative velocity transformation formula. The spurious nature of the correlated `length contraction' and `relativity of simultaneity' effects of conventional special relativity is also demonstrated. In consequence, an argument given, claiming to demonstrate that an upper li...

  5. Calcite twin morphology : a low-temperature deformation geothermometer

    OpenAIRE

    Ferrill, David A.; Morris, Alan P.; Evans, Mark A; Burkhard, Martin; Groshong Jr., Richard H.; Onasch, Charles M.

    2005-01-01

    Twinning of the e-plane is the dominant crystal–plastic deformation mechanism in calcite deformed below about 400 °C. Calcite in a twin domain has a different crystallographic orientation from the host calcite grain. So-called thin twins appear as thin black lines when viewed parallel to the twin plane at 200–320× magnification under a petrographic microscope. Thick twins viewed in the same way have a microscopically visible width of twinned material between black lines. Calcite e-twin width ...

  6. Undiagnosed xiphopagus twins: a perinatal malady

    Directory of Open Access Journals (Sweden)

    Gowri Dorairajan

    2012-02-01

    Full Text Available Conjoined twins are a very rare entity. It is associated with poor survival rate in the presence of vital organ sharing. The entity can be diagnosed as early as the first trimester. A conjoined twin diagnosed late in labor is a malady with high perinatal mortality and maternal morbidity. We present one such case of xiphopagus twins. The management of a case diagnosed late in labor can be very challenging. Such obstetric challenges can be avoided by a meticulous early scan with a high index of suspicion, especially in the absence of separating membrane while scanning multiple pregnancies.

  7. Successful twin pregnancy after orthotopic liver transplantation

    Directory of Open Access Journals (Sweden)

    Coelho Júlio Cezar Uili

    2002-01-01

    Full Text Available AIM: Report of a case of successful twin pregnancy following liver transplantation. PATIENT AND METHOD: A 42-year-old nulliparous-woman was subjected to an orthotopic liver transplantation due to Budd-Chiari syndrome. Sixteen months after the transplantation, an ultrasonography revealed twin pregnancy. Her prenatal course was uneventful, except for mild arterial hypertension. The immunosuppressive agents used during pregnancy were cyclosporine and prednisone. RESULT: The patient gave birth to two healthy girls at 37 weeks of gestation. The patient's postpartum course was uneventful with normal liver and renal function tests. CONCLUSION: Following successful pregnancy, women may become pregnant and give birth to normal children, including twins

  8. On Radar Time and the Twin `Paradox'

    CERN Document Server

    Dolby, C E; Dolby, Carl E.; Gull, Stephen F.

    2001-01-01

    In this paper we apply the concept of radar time (popularised by Bondi in his work on k-calculus) to the well-known relativistic twin `paradox'. Radar time is used to define hypersurfaces of simultaneity for a class of travelling twins, from the `Immediate Turn-around' case, through the `Gradual Turn-around' case, to the `Uniformly Accelerating' case. We show that this definition of simultaneity is independent of choice of coordinates, and assigns a unique time to any event (with which the travelling twin can send and receive signals), resolving some common misconceptions.

  9. Unequal but monozygous: a history of twin-twin transfusion syndrome.

    Science.gov (United States)

    Obladen, Michael

    2010-03-01

    Twin-twin transfusion is the major cause of mortality and morbidity in monochorionic twins. Its pathogenesis has been gradually elucidated over the last three centuries. Among obstetricians, there was a long-lasting controversy on the existence of placental anastomoses and whether or not to tie the placental end of the firstborn infant's cord. However, a twin pregnancy practically never could be excluded. Stalpart van der Wiel described a twin-twin vessel connection in 1687. Studies on interfetal anastomoses using injection of placental vessels were published by Smellie in 1752, Osiander in 1781, and Brachet in 1821. Different types of anastomoses, and their associated fetal disorders were classified by Schatz in a series of papers at the end of the 19(th) century. With the advent of ultrasound and laser techniques, prenatal diagnosis and treatment became available in the last decade of the 20(th) century.

  10. Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo

    International Nuclear Information System (INIS)

    Investigations into tumor angiogenesis and antiangiogenic treatment have renewed interest in tumor perfusion. To image tumor blood-pool by PET, suitable tracers are not generally available. In this experimental study, we characterized a 68Ga-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) conjugate of rat serum albumin (68Ga-DOTA-RSA) in vivo using a generator-produced isotope. Biodistribution was determined in ACI rats after intravenous administration of 3-6 MBq of 68Ga-DOTA-RSA. Three ACI rats were imaged over 1 h by dynamic PET after intravenous administration of 15-25 MBq of 68Ga-DOTA-RSA while the blood-pool activity was recorded simultaneously in a closed extracorporeal loop (ECL) between the carotid artery and the jugular vein. Time-activity curves (TACs) were obtained from volume of interest (VOI) analysis and from the ECL data. Stability and metabolites in plasma and urine were analyzed by size exclusion HPLC (SE-HPLC) 1 h after intravenous injection of 67Ga-DOTA-RSA. Blood radioactivity decreased by 10% and 18% from 10 to 60 min p.i. by biodistribution and PET or ECL, respectively. Tissue sampling between 10 and 60 min p.i. showed slight increases in the uptake of spleen, myocardium, kidney and skeletal muscle while hepatic accretion remained unchanged. Total urinary excretion after 60 min amounted to 9% of the injected dose. HPLC demonstrated a single urinary metabolite corresponding in size to gallium-labeled DOTA. 68Ga-DOTA-RSA is a blood-pool tracer whose physical and biological half-life is well suited for PET. Our findings support clinical imaging using 68Ga-DOTA-labeled human serum albumin (HSA). The generator-produced label makes 68Ga-DOTA-labeled albumin continuously available even to centers lacking an in-house cyclotron

  11. Aluminium and nickel in human albumin solutions

    DEFF Research Database (Denmark)

    Gammelgaard, Bente; Sandberg, E

    1989-01-01

    Five different brands of commercially available human albumin solutions for infusion were analysed for their aluminium and nickel contents by atomic absorption spectrometry. The aluminium concentrations ranged from 12 micrograms/l to 1109 micrograms/l and the nickel concentrations ranged from 17...... micrograms/l to 77 micrograms/l. Examination of the aluminium and nickel contents of the constituents for the production of one brand showed too low levels to explain the final contamination of the product. By following the aluminium and nickel concentrations of the same brand during the production...... of a batch of albumin solution, filtration was shown to contribute to contamination, although the largest increase in aluminium as well as nickel concentrations appeared during the bulk concentrating process. To avoid health risks to certain patients, regulations should be established requiring aluminium...

  12. Hirschsprung’s disease in twin to twin transfusion syndrome: A case report

    OpenAIRE

    Park, Hye Won; Cho, Min Jeng; Kim, Wook Youn; Kwak, Byung Ok; Kim, Min Hee

    2014-01-01

    Twin to twin transfusion syndrome (TTTS) is caused by aberrant vascular connections between infant twins and results in high morbidity and mortality in the perinatal period. In donor infants with TTTS and symptoms of intestinal obstruction, small-bowel lesions have been reported in most cases. We report on a 33+6 gestational wk donor infant with TTTS who had intermittent obstructive episodes, including delayed meconium passage and colonic dilatation on abdominal X-ray. The diagnosis of Hirsch...

  13. A case report: The role of amnioreduction plus septostomy in management of twin twin transfusion syndrome

    OpenAIRE

    GÜRBÜZ, Ayşe; Berna, HALİLOĞLU; Aydın, GÜRBÜZ; Öztürk, GAZİYİZ Göknur

    2004-01-01

    We have reported our experience with intentional puncture of the intervening membrane (septostomy)in combination with amnioreduction in a severe twin to twin transfusion syndrome case. One of the fetuses (in the form of stuck twin) had anydramnios and nonvisible bladder. The other fetuse had anyhydramnios and enlarged bladder. We support thatamniotic septostomy plus amnioreduction is a basic and promising method for the management of this syndrome.

  14. Twin-Twin Transfusion Syndrome Presenting as Polyhydramnios in Both Fetuses Secondary to Spontaneous Microseptostomy

    OpenAIRE

    David N. Hackney; Nahla Khalek; Julie Moldenhauer; Tulin Ozcan

    2013-01-01

    The presence of polyhydramnios and oligohydramnios is pathognomonic for twin–twin transfusion syndrome (TTTS). However, polyhydramnios of both twins can exist in TTTS in the setting of a septostomy of the dividing membrane. In prior reported cases of dual polyhydramnios TTTS, the septostomy was identified through either ultrasound or fetoscopy thus helping to establish the diagnosis of TTTS with an unusual presentation. The presented case is a set of monochorionic, diamniotic twins who presen...

  15. Albumin synthesis in protein energy malnutrition

    International Nuclear Information System (INIS)

    Assessment of protein nutritional status during re-feeding children with protein energy malnutrition (PEM) can be difficult. We hypothesized that the fractional synthesis rate (FSR) of albumin, as measured by stable isotope technology, would serve as an objective measure of changes in protein status, and that increased amounts of dietary protein (15% of calories vs 10%) would lead to higher FSR. Eight (5 M, 3 F) Peruvian children (mean age 15.5 months) with PEM (mean wt/ht Z score = -2.47) were studied twice during the first week of admission by the flooding dose technique. An intravenous dose of 13C-leucine (57 mg/kg, 99 atom%) was given and serial blood samples were drawn in intervals up to 90 minutes in order to measure isotopic enrichment of serum albumin. Mean FSR for the day one infusion was 6.11% (range 3.07 - 15.37%) (n = 8). Mean FSR for the follow-up infusion was 7.67% (range 3.63 - 12.37%) (n = 5), and FSR was no different between the two dietary groups. FSR on day one was inversely related to age (r = -0.62), and one patient with Shigella dysentery had the highest FSR (15.9%). We conclude that FSR of albumin can be measured successfully in children with PEM using the flooding dose technique, and that assessment of albumin FSR holds promise to help determine protein requirements and status during recovery from PEM. (author). 14 refs, 6 figs, 3 tabs

  16. Birth weight for gestational age among Flemish twin population

    OpenAIRE

    Doom, E.C.G.; Delbaere, I.; Martens, G.; Temmerman, M.

    2012-01-01

    Objective: The aim of this study was to develop birth weight references for twins. Mean birth weights of individual twins are lower than those of singletons, hence singleton birth weight curves may not be suitable to assess twin birth weights. Study design: Twin birth weight curves were developed according to gestational age, gender, parity and mode of conception. The curves are based on population-based data of 40,494 twins born in Flanders, Belgium between 1987 and 2007. Results: A differen...

  17. Dietary intake and urinary excretion of lignans in Finnish men

    DEFF Research Database (Denmark)

    Nurmi, Tarja; Mursu, Jaakko; Peñalvo, José L;

    2010-01-01

    of plant lignans was explained 14 % by the intake of rye products and intake of coffee, and consequently 3-7 % by the intake of water-insoluble fibre. The urinary excretion of enterolactone was explained 11 % by the intake of vegetables and rye products, 14 % by the intake of water-soluble fibre and only 4......Intake of lignans has been assessed in different study populations, but so far none of the studies has compared the daily intake of lignans and the urinary excretion of plant and enterolignans. We assessed the intake of lariciresinol, pinoresinol, secoisolariciresinol and matairesinol in 100...... Finnish men consuming their habitual omnivorous diet, and measured the 24 h urinary excretion of plant and enterolignans to compare the intake and metabolism. Dietary determinants of lignan intake and their urinary excretion were also determined. The mean intake of lignans was 1224 (sd 539) mug...

  18. The role of albumin in nutritional support.

    Science.gov (United States)

    Mobarhan, S

    1988-12-01

    Hypoalbuminemia is considered one of the hallmarks of protein-calorie malnutrition and chronic liver disease. Recently, serum albumin has also been proposed as a critical predictor of the response to nutritional support and tolerance to enteral feeding in critically ill patients. Albumin is essential for maintenance of plasma colloidal osmotic pressure, prevention of edema, and transport of certain drugs and nutrients. Experimental studies have shown that rapid plasma expansion and reduced plasma protein concentration and osmotic pressure induce a net secretion of sodium and water into the small intestinal lumen. However, the effects of chronic hypoalbuminemia per se on intestinal absorption, independent of malnutrition, have not been fully studied. It is documented that both chronic illness and malnutrition may profoundly affect intestinal anatomical structure and function, inducing some degree of malabsorption. In the last few years, some have advocated albumin infusion to improve clinical response to patients with hypoalbuminemia receiving parenteral nutritional support or to reduce intestinal intolerance and diarrhea in patients receiving enteral tube feeding. A review of the literature shows that both clinical and experimental data to support these suggestions are scarce and further investigations are needed. Hypoalbuminemia is one of many parameters of malnutrition, and it is unlikely that correction of a single parameter for a short time would lead to major clinical benefits. PMID:3147998

  19. Twin boundary energy and characterization of charge redistribution near the twin boundaries of cupperate superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Mohammadi, Mahnaz [Faculty of Physics, University of Kashan, Kashan (Iran, Islamic Republic of); Khoshnevisan, Bahram, E-mail: m.mohammadi_2@grad.kashanu.ac.ir [Faculty of Physics, University of Kashan, Kashan (Iran, Islamic Republic of); Javad Hashemifar, S. [Department of Physics, Isfahan University of Technology, Isfahan (Iran, Islamic Republic of)

    2014-12-15

    Highlights: • Ab initio simulation for twin boundary energy in YBCO system for the 1st time. • Study of the twin boundary energy variation versus the inserted strain. • Proportionality of twin lamella width by the inserted strain. • Local charge transfer and charge redistribution on the twin planes. • Total DOSs for the twined system at Fermi level is higher than the untwined one. • This explain the effect of twin boundaries in agreement with experimental data. - Abstract: Ab-initio calculations under general gradient approximation have been employed for the first time to find out twin boundary energy, γ, in twined YBCO systems. Despite a vast discrepancy in reported experimental values, our results show that the γ value falls in the range of 40–85 mJ/m{sup 2}. On the other hand, functional form of γ versus inserted strains shows that the mean value for the twin width lamella would tend to approach zero as the strain goes to zero. We have also investigated the local charge transfer and the modification of the electronic states of the basal and twin planes in YBCO, because the charge redistribution at interfaces can modify transport across the grains considerably and determine the applicability of high-T{sub c} superconductors in the electronic applications. The total density of electronic states at the Fermi level for the twined system is enhanced in comparison with the untwined one. Our results explain the influence of twin boundaries in superconductive properties of YBCO, in experimental situations.

  20. Urinary Kallikrein Excretion in Essential and Mineralocorticoid Hypertension

    OpenAIRE

    Holland, O. Bryan; Chud, James M.; Braunstein, Helen

    1980-01-01

    Urinary kallikrein excretion has been reported to be decreased in patients with essential hypertension and elevated in patients with primary aldosteronism as a reflection of mineralocorticoid activity. Low renin essential hypertension (LREH) has been postulated to result from excess production of an unknown mineralocorticoid(s). Urinary kallikrein excretion was compared in outpatients with essential hypertension, mineralocorticoid hypertension (primary aldosteronism and 17α-hydroxylase defici...

  1. Ammonia excretion in mytilid mussels is facilitated by ciliary beating.

    Science.gov (United States)

    Thomsen, J; Himmerkus, N; Holland, N; Sartoris, F J; Bleich, M; Tresguerres, M

    2016-08-01

    The excretion of nitrogenous waste products in the form of ammonia (NH3) and ammonium (NH4 (+)) is a fundamental process in aquatic organisms. For mytilid bivalves, little is known about the mechanisms and sites of excretion. This study investigated the localization and the mechanisms of ammonia excretion in mytilid mussels. An Rh protein was found to be abundantly expressed in the apical cell membrane of the plicate organ, which was previously described as a solely respiratory organ. The Rh protein was also expressed in the gill, although at significantly lower concentrations, but was not detectable in mussel kidney. Furthermore, NH3/NH4 (+) was not enriched in the urine, suggesting that kidneys are not involved in active NH3/NH4 (+) excretion. Exposure to elevated seawater pH of 8.5 transiently reduced NH3/NH4 (+) excretion rates, but they returned to control values following 24 h acclimation. These mussels had increased abundance of V-type H(+)-ATPase in the apical membranes of plicate organ cells; however, NH3/NH4 (+) excretion rates were not affected by the V-type H(+)-ATPase specific inhibitor concanamycin A (100 nmol l(-1)). In contrast, inhibition of ciliary beating with dopamine and increased seawater viscosity significantly reduced NH3 excretion rates under control pH (8.0). These results suggest that NH3/NH4 (+) excretion in mytilid mussels takes place by passive NH3 diffusion across respiratory epithelia via the Rh protein, facilitated by the water current produced for filter feeding, which prevents accumulation of NH3 in the boundary layer. This mechanism would be energy efficient for sessile organisms, as they already generate water currents for filter feeding. PMID:27489216

  2. Comparison of Naturally Conceived and IVF-DZ Twins in the Netherlands Twin Registry: A Developmental Study

    Directory of Open Access Journals (Sweden)

    Catharina E. M. van Beijsterveldt

    2011-01-01

    Full Text Available In a large set of twin pairs, we compared twins born after IVF to naturally conceived twins with respect to birth characteristics, growth, attainment of motor milestones, and emotional and behavioral problems. Twin families were registered with the Netherlands Twin Register. We included 1534 dizygotic (DZ twins born after IVF, 5315 naturally conceived (NC DZ twins, and 1504 control NC DZ twins who were matched to the IVF twins based on maternal age, maternal educational level, smoking during pregnancy, gestational age, and offspring sex. Data were obtained by longitudinal surveys sent to fathers, mothers, and teachers at ages 1, 2, 3, 7, 10, and 12 years. Results showed no differences in growth, in attainment of motor milestones, and in behavioral development between IVF and matched NC twins. It can be concluded that for nearly all aspects, development in IVF and NC children is similar.

  3. The Radiative Z2 Breaking Twin Higgs

    CERN Document Server

    Yu, Jiang-Hao

    2016-01-01

    In twin Higgs model, the Higgs boson mass is protected by a $Z_2$ symmetry. The $Z_2$ symmetry needs to be broken either explicitly or spontaneously to obtain misalignment between electroweak and new physics vacua. We propose a novel $Z_2$ breaking mechanism, in which the $Z_2$ is spontaneously broken by radiative corrections to the Higgs potential. Two twin Higgses with different vacua are needed, and vacuum misalignment is realized by opposite but comparable contributions from gauge and Yukawa interactions to the potential. Due to fully radiative symmetry breaking, the Higgs sector is completely determined by twin Higgs vacuum, Yukawa and gauge couplings. There are eight pseudo-Goldstone bosons: the Higgs boson, inert doublet Higgs, and three twin scalars. We show the 125 GeV Higgs mass and constraints from Higgs coupling measurements could be satisfied.

  4. Twin Cities Metro Hybrid Landcover 2000 (Raster)

    Data.gov (United States)

    Minnesota Department of Natural Resources — The Hybrid Landcover is an attempt to clean up the University of Minnesota Remote Sensing Lab's 2000 LandSat Land Cover for the Twin Cities 7-county metropolitan...

  5. Thoracopagus conjoined twin: an unusual presentation

    Directory of Open Access Journals (Sweden)

    Rajesh Kumari

    2014-02-01

    Full Text Available Conjoined twins are among rare clinical conditions observed by obstetricians. Due to rare incidence of this condition there is general lack of knowledge among obstetricians, especially at primary care level which leads to missed diagnosis during antenatal period. The management of this condition is complex especially in cases where the diagnosis is not known before onset of labour. A 30 - year old Hindu lady was referred to us from other hospital with diagnosis of twin pregnancy and prolonged second stage of labour. Clinical examination revealed findings of ruptured uterus and foetal head of one baby and feet of second baby were outside the introitus. Emergency laparotomy was done which revealed conjoined twins. This article report clinical course of a thoracopagus conjoined twin. The relevant literature is also reviewed. [Int J Reprod Contracept Obstet Gynecol 2014; 3(1.000: 245-247

  6. Twin Screw Mixer/Fine Grind Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The 40-mm Twin-Screw Mixer/Extruder (TSE) pilot plant is a continuous, remotely operated, flexible facility that can significantly enhance safety and environmental...

  7. A twin paradox for 'clever' students

    CERN Document Server

    Ghosal, S K; Nepal, S; Das, Debarchana; Nepal, Saroj

    2005-01-01

    We discuss the twin paradox or the clock paradox under the small velocity approximation of special relativity. In this paper the traveller twin of the standard twin parable sets out with a non-relativistic speed for the trip leaving behind the stay-at-home one on earth and continues up to a distance and finally returns home with the same speed when the siblings can compare their ages or their initially synchronized wrist watches. The common knowledge that at small velocities the length contraction and time dilation effects of special relativity can be ignored so that the world becomes essentially classical, tends to lead to a paradox in connection with the twin problem, which a "clever" student eventually discovers. After discussing and resolving the issue, some more related paradoxes have been presented. The resolution of all these problems provides some additional insight into the century old paradox.

  8. Twin screw subsurface and surface multiphase pumps

    Energy Technology Data Exchange (ETDEWEB)

    Dass, P. [CAN-K GROUP OF COMPANIES, Edmonton, Alberta (Canada)

    2011-07-01

    A new subsurface twin screw multiphase pump has been developed to replace ESP and other artificial lift technologies. This technology has been under development for a few years, has been field tested and is now going for commercial applications. The subsurface twin screw technology consists of a pair of screws that do not touch and can be run with a top drive or submersible motor; and it carries a lot of benefits. This technology is easy to install and its low slippage makes it highly efficient with heavy oil. In addition twin screw multiphase pumps are capable of handling high viscosity fluids and thus their utilization can save water when used in thermal applications. It also induces savings of chemicals because asphaltenes do not break down easily as well as a reduction in SOR. The subsurface twin screw multiphase pump presented herein is an advanced technology which could be used in thermal applications.

  9. Cord entanglement in monoamniotic twin pregnancies

    DEFF Research Database (Denmark)

    Lyndrup, J; Schouenborg, Lars Øland

    1987-01-01

    Monoamniotic twin pregnancy involves a heavy risk of fatal umbilical cord entanglement. Two cases are reported. In the first case, both twins were found dead in the 36th week, and the monoamnionicity was recognized at birth. In the second case, the monoamnionicity was discovered during an ultraso......Monoamniotic twin pregnancy involves a heavy risk of fatal umbilical cord entanglement. Two cases are reported. In the first case, both twins were found dead in the 36th week, and the monoamnionicity was recognized at birth. In the second case, the monoamnionicity was discovered during...... an ultrasound examination, and cord entanglement was suspected in the 35th week on the basis of a non-stress test (NST) with variable decelerations. Cesarean section was performed and two healthy children were delivered....

  10. Infantile Perineal Protrusion in Two Monochorionic Twins

    Directory of Open Access Journals (Sweden)

    Paola Cavicchioli

    2014-11-01

    Full Text Available Case Report - Two female monochorionic-monoamniotic twins showed the same kind of infantile perineal protrusion (IPP at birth. Lesions in both twins progressively healed until resolution in 6 weeks' time; none of the twins have manifested, till date, alvus disturbances. Discussion and Literature Review - A literature review numbers approximately 100 reports of IPP. This condition has been classically classified into three categories: congenital/familiar (i.e., female sex, positive parental history of IPP, acquired (mainly due to constipation, and associated with lichen sclerosus et atrophicus. Conclusions and Final Remarks - This case report describes, for the first time, the presence of IPP in monochorionic-monoamniotic twins, supporting the existence of hereditary/genetic factors in the developing of this condition.

  11. Paternal age and telomere length in twins

    DEFF Research Database (Denmark)

    Hjelmborg, Jacob B; Dalgård, Christine; Mangino, Massimo;

    2015-01-01

    Telomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres in sperm of older men and it might be an 'epigenetic' mechanism through which paternal age plays a role in telomere length regulation in humans....... Based on two independent (discovery and replication) twin studies, comprising 889 twin pairs, we show an increase in the resemblance of leukocyte telomere length between dizygotic twins of older fathers, which is not seen in monozygotic twins. This phenomenon might result from a paternal age......-dependent germ stem cell selection process, whereby the selected stem cells have longer telomeres, are more homogenous with respect to telomere length, and share resistance to aging....

  12. The Twin Research Registry at SRI International.

    Science.gov (United States)

    Krasnow, Ruth E; Jack, Lisa M; Lessov-Schlaggar, Christina N; Bergen, Andrew W; Swan, Gary E

    2013-02-01

    The Twin Research Registry (TRR) at SRI International is a community-based registry of twins established in 1995 by advertising in local media, mainly on radio stations and in newspapers. As of August 2012, there are 3,120 same- and opposite-sex twins enrolled; 86% are 18 years of age or older (mean age 44.9 years, SD 16.9 years) and 14% less than 18 years of age (mean age 8.9 years, SD 4.5); 67% are female, and 62% are self-reported monozygotic (MZ). More than 1,375 twins have participated in studies over the last 15 years in collaboration with the University of California Medical Center in San Francisco, the University of Texas MD Anderson Cancer Center, and the Stanford University School of Medicine. Each twin completes a registration form with basic demographic information either online at the TRR Web site or during a telephone interview. Contact is maintained with members by means of annual newsletters and birthday cards. The managers of the TRR protect the confidentiality of twin data with established policies; no information is given to other researchers without prior permission from the twins; and all methods and procedures are reviewed by an Institutional Review Board. Phenotypes studied thus far include those related to nicotine metabolism, mutagen sensitivity, pain response before and after administration of an opioid, and a variety of immunological responses to environmental exposures, including second-hand smoke and vaccination for seasonal influenza virus and Varicella zoster virus. Twins in the TRR have participated in studies of complex, clinically relevant phenotypes that would not be feasible to measure in larger samples. PMID:23084148

  13. TWIN: Personality-based Intelligent Recommender System

    OpenAIRE

    Roshchina, Alexandra; Cardiff, John; Rosso, Paolo

    2015-01-01

    This paper presents the Tell me What I Need (TWIN) Personality-based Intelligent Recommender System, the goal of which is to recommend items chosen by like-minded (or twin ) people with similar personality types which we estimate from their writings. In order to produce recommendations it applies the results achieved in the personality from the text recognition research field to Personality-based Recommender System user profile modelling. In this way it creates a bridge between the efforts...

  14. Twin birth order, birthweight and birthweight discordance: any relationship

    Directory of Open Access Journals (Sweden)

    Onyiriuka A.N.

    2010-12-01

    Full Text Available Background: It is widely believed that in twin pairs, at birth, the first-born weigh more than the second-born but this concept has been challenged. Objective: To assess the truthfulness of this common concept that first-born twins are usually heavier than their second-born siblings at birth. Methods: In a series of 104 sets of live-born twins, the birth weights of first-born twins were compared with those of their second-born siblings, after controlling for gender. Their intra-pair birthweight differences were determined and twin pairs whose birthweight difference was 15% or more were designated as discordant. Results: Twin I was heavier than Twin II in 61.5% of cases while Twin II was heavier than Twin I in 28.9% of cases. Twins I and II had equal birthweights in 9.6% of cases. Comparing the mean birthweight of the first-born-male twin with that of second-born- male twin, it was 2515+427g (95% Confidence Interval, CI=2402-2628 versus 2432 +435g (95% CI=2321-2543 p>0.05. The mean birthweight of first-born-female twin was 2326+445g (95% CI=2214-2439 while that of the second-born-female twin was 2325+501g (95% CI=2197-2453 p>0.05. When the birthweight difference exceeded 750g, the probability that Twin I will be heavier than Twin II was 83.3% (5 of 6. Conclusion: Although the first-born twin was more often heavier than their second-born siblings, either could weigh more or less at birth. The larger the birthweight difference between growth-discordant twin pair, the greater the probability that the heavier twin would be delivered first

  15. Association of the estimated 24-h urinary sodium excretion with albuminuria in adult koreans: the 2011 Korea National Health and Nutrition Examination Survey.

    Directory of Open Access Journals (Sweden)

    Sang Youb Han

    Full Text Available BACKGROUND: Sodium intake and albuminuria have important roles in blood pressure and renal progression. Although their relationship has been reported, the results have not been consistent and all studies have examined small populations. OBJECTIVE: This study investigated the role of the estimated 24-h urinary sodium excretion as a marker of sodium intake and albuminuria. DESIGN: This investigation included 5,187 individuals age 19 years and older from a cross-sectional, nationally representative, stratified survey: The Korea National Health and Nutrition Examination Survey (KNHANES V-2, in 2011. Albuminuria was defined as a urinary albumin/creatinine ratio ≥30 mg/g. The 24-h urinary sodium excretion was estimated from a spot urine. RESULTS: On classifying our participants into quartiles based on the estimated 24-h urinary sodium excretion, the prevalence of albuminuria increased with the 24-h urinary sodium excretion (5.3, 5.7, 7.5, and 11.8% in the first through fourth quartiles, respectively, p for trend <0.001. Even after adjusting for age, sex, diabetes, obesity, and hypertension, the significance persisted. In a multiple logistic regression analysis, the second and third quartiles of the estimated 24-h urinary sodium excretion were not associated with the presence of albuminuria with the first quartile as a control. However, the fourth quartile was significantly associated with the presence of albuminuria (odds ratio 1.61 [95% confidence interval 1.71-2.21], p = 0.003 after adjusting for age, sex, diabetes, obesity, and hypertension. CONCLUSIONS: These findings suggest that salt intake is associated with the presence of albuminuria in the general Korean adult population.

  16. Effect of a Karate Competition on Urinary Excretion of Proteins with High Molecular Weight (Glomerular proteinuria in Young Male Karatekas

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Kohanpour

    Full Text Available The aim of the present study was to investigate the effect of a karate competition on the urinary excretion of proteins with high molecular weight and urinary creatinine to protein ratio in young male karate as. Ten young male karate as with the age range of 25±2.63 years, height of 175.7±5.15 cm and weight of 71.5±8.61 kg voluntarily took part in this study and participated in a karate competition. Before and 20 min after the competition, the urinary sample was collected and the levels of albumin, total protein, creatinine and urinary creatinine to protein ratio were measured and calculated. To investigate the changes of urinary proteins caused by competition, the student’s t-test for dependent groups was used. Glomerular proteinuria increased after the competition; however, it was only significant for albumin and creatinine (p = 0.009 and p = 0.018, respectively. Although total protein increased after the competition, it was not statistically significant (p = 0.184 and the creatinine to protein ratio did not make any significant changes (p = 0.532. Creatinine to protein ratio was less than 0.1 for the samples before and after the competition; therefore, proteinuria had a physiological range which was very far from nephritic and pathological proteinuria ranges; thus, it was not harmful.

  17. [Trans-intestinal cholesterol excretion (TICE): a new route for cholesterol excretion].

    Science.gov (United States)

    Blanchard, Claire; Moreau, François; Cariou, Bertrand; Le May, Cédric

    2014-10-01

    The small intestine plays a crucial role in dietary and biliary cholesterol absorption, as well as its lymphatic secretion as chylomicrons (lipoprotein exogenous way). Recently, a new metabolic pathway called TICE (trans-intestinal excretion of cholesterol) that plays a central role in cholesterol metabolism has emerged. TICE is an inducible way, complementary to the hepatobiliary pathway, allowing the elimination of the plasma cholesterol directly into the intestine lumen through the enterocytes. This pathway is poorly characterized but several molecular actors of TICE have been recently identified. Although it is a matter of debate, two independent studies suggest that TICE is involved in the anti-atherogenic reverse cholesterol transport pathway. Thus, TICE is an innovative drug target to reduce -cardiovascular diseases.

  18. Spondyloepiphyseal Dysplasia Tarda in Twins

    Directory of Open Access Journals (Sweden)

    Ferhat Çekmez

    2011-08-01

    Full Text Available Introduction: Spondyloepiphyseal dysplasia (SED is a genetically heterogeneous disorder often associated with the early onset of osteoarthrosis. The X-linked recessive form (SEDL affects boys and is characterized by reduced height, arm span exceeding total height, and barrel chest deformity. The radiographic phenotype comprises a hump-shaped deformity of vertebral bodies and mild epiphyseal dysplasia of the femoral head associated with early signs of hip arthrosis.The disorder is caused by mutations in the SEDL (or sedlin gene on Xp22.12-p22.31. SED should be kept in mind as a differential diagnosis in men with early “primary” bilateral osteoarthrosis.Case Report: Here, 11 years old twins diagnosed as SED due to walking disability, limitation of joint motion, pain at the hips and disability in standing for a long time were presented. Discussion: This rare skelatal dysplasia must be kept in mind in patients with painful spine and hip joints, and walking disability. (Jo­ur­nal of Cur­rent Pe­di­at­rics 2011; 9: 97-9

  19. Twin probes for space geodesy

    International Nuclear Information System (INIS)

    The twin probe method, proposed by Bertotti and Colombo (1972) to get rid of nongravitational forces in interplanetary space, can be applied to a near-Earth orbit to eliminate the atmospheric drag. Two equal pairs of probes, each pair consisting of two passive, small and dense spheres of equal surface and different masses, are flown on a circular orbit at an altitude of about 300 km. Each pair determines the motion of an ideal point which feels only the gravitational forces. They are separated by a distance d of (100/200) km and are tracked from a spacecraft or the Space Shuttle, flying at the same altitude. The relative motion of the two ideal points is reconstructed and yields a measurement of the fine structure of the Earth gravitational field, corresponding to a harmonic order l approximately a/d (a is the radius of the Earth). The tracking can be done by laser ranging to the four spheres, covered by corner reflectors; Doppler ranging is more convenient for higher values of l and can also be used. The accuracy in the compensation of the non-gravitational forces and in the measurements one needs for a given l are discussed in detail. (author)

  20. Niobium and tantalum: indispensable twins

    Science.gov (United States)

    Schulz, Klaus; Papp, John

    2014-01-01

    Niobium and tantalum are transition metals almost always paired together in nature. These “twins” are difficult to separate because of their shared physical and chemical properties. In 1801, English chemist Charles Hatchett uncovered an unknown element in a mineral sample of columbite; John Winthrop found the sample in a Massachusetts mine and sent it to the British Museum in London in 1734. The name columbium, which Hatchet named the new element, came from the poetic name for North America—Columbia—and was used interchangeably for niobium until 1949, when the name niobium became official. Swedish scientist Anders Ekberg discovered tantalum in 1802, but it was confused with niobium, because of their twinned properties, until 1864, when it was recognized as a separate element. Niobium is a lustrous, gray, ductile metal with a high melting point, relatively low density, and superconductor properties. Tantalum is a dark blue-gray, dense, ductile, very hard, and easily fabricated metal. It is highly conductive to heat and electricity and renowned for its resistance to acidic corrosion. These special properties determine their primary uses and make niobium and tantalum indispensable.

  1. A Holographic Twin Higgs Model

    CERN Document Server

    Geller, Michael

    2014-01-01

    We present a UV completion of the twin Higgs idea in the framework of holographic composite Higgs. The SM contribution to the Higgs potential is effectively cut off by the SM-singlet mirror partners at the sigma-model scale f, naturally allowing for m_{KK} beyond the LHC reach. The bulk symmetry is SU(7) X SO(8), broken on the IR brane into SU(7) X SO(7) and on the UV brane into (SU(3) X SU(2) X U(1))^{SM} X (SU(3) X SU(2) X U(1))^{mirror} X Z2. The field content on the UV brane is the SM, extended by a sector transforming under the mirror gauge group, with the Z2 exchanging the two sectors. An additional Z2 breaking term is holographically generated to reproduce the Higgs mass and VEV, with a mild O(10%) tuning. This model has no trace at the LHC, but can by probed by precision Higgs measurements at future lepton colliders, and by direct searches for KK excitations at a 100 TeV collider.

  2. Study of the deuterated albumin by FT-IR spectroscopy

    International Nuclear Information System (INIS)

    The albumin is a protein from the soluble or corpuscular protein class, which exists in cells, in dissolved state or in form of a hydrated gel. Proteins are essential constituents beside water, inorganic salts, lipids, carbon hydrates, vitamins, enzymes. The albumin is also a protein soluble in water and in diluted electrolyte solutions (acids, bases and salts). The investigation of the vibration isotopic effect has a great importance both for the diatomic molecules and for the polyatomic molecules. This paper is the first from a series of works which are intended to study the physico-chemical properties of the deuterated albumin and of the albumin solutions in heavy water by an isotopic exchange method. To put in evidence H-D exchange, the FT-IR spectroscopy is used when the deuterated albumin has different layer thickness. It is also of interest to elucidate the isotopic exchange between the hydrogen and oxygen atoms in bovine serum albumin macromolecules. (authors)

  3. Severe preeclampsia cured by heparin in a patient with twin-twin transfusion syndrome

    Institute of Scientific and Technical Information of China (English)

    CHU Hong-nü; ZHOU Cai-yun

    2007-01-01

    @@ Heparin therapy for preeclampsia has been reported frequently.1-3 Most of the authors used heparin to prevent thrombosis and achieved good results. But its mechanism is not clear.4 Here we describe a case of severe early-onset preeclampsia complicated with hypercoagulable state, fetal growth restriction, and twin-twin transfusion syndrome, that responded well to heparin.

  4. Quantitative urinary protein excretion in chronic renal failure.

    Science.gov (United States)

    McMorrow, R G; Galla, J H; Luke, R G

    1982-01-01

    The diagnostic value of the measurement of quantitative proteinuria in patients with a creatinine clearance of less than 10 ml/min was determined in patients seen in a single center over a 5-year period. All 126 patients in whom a definitive renal diagnosis was possible were included. Patients with glomerular disease excreted 6.1 +/- 0.6 g/day and patients with interstitial disease 1.5 +/- 0.3 g/day (p less than 0.001). In individual patients with end-stage renal disease, however, measurement of urinary protein excretion excluded (with 95% confidence levels) patients with interstitial diseases only when greater than 2.9 g/day. To examine the natural history of proteinuria in progressive renal disease, urinary protein, absolute and factored for glomerular filtration rate (GFR; creatinine clearance), was determined at 10 ml/min decrements in GFR for patients with membranoproliferative glomerulonephritis, idiopathic membranous glomerulonephritis and focal glomerulosclerosis. Quantitative urinary protein excretion was relatively constant as GFR fell but did fall significantly at less than 10 ml/min but only to 4.8-7.0 g/day at even that level. Urinary protein excretion/GFR increased as GFR fell, particularly at end stage where a highly significant four-fold rise was seen; an increase also occurred in patients with primary interstitial disease. Similar data were obtained for 34 randomly selected patients after at least 1 year of chronic hemodialysis. Although a significant decline in absolute urinary protein excretion occurred during the year of dialysis to levels not different between glomerular and interstitial disease, urinary protein excretion/unit GFR remained elevated. Increased urinary protein excretion/unit GFR may result from a functional adaptation of remaining nephrons in response to declining renal mass.

  5. Conflicting clinical trial data: a lesson from albumin

    OpenAIRE

    Martin, Greg

    2005-01-01

    Albumin is a frequently prescribed drug in hospitalized patients, and its effect on clinical outcomes has been scrutinized in recent years. Data from meta-analyses has suggested harm related to albumin therapy in critically ill patients, and new observational data are consistent with these results. However, appropriately powered randomized, controlled trials have shown albumin to be safe in broad groups of critically ill patients. This article will discuss the reasons for differences between ...

  6. Interaction of antithrombin III with preadsorbed albumin-heparin conjugates

    OpenAIRE

    Hennink, W.E.; Ebert, C.D.; Kim, S. W.; Breemhaar, W.; Bantjes, A.; Feijen, J.

    1984-01-01

    The adsorption of antithrombin III (AT III) onto polystyrene surfaces preadsorbed with albumin or albuminheparin conjugates was studied using a two step enzyme immuno assay. When AT III-buffer solutions were used, the highest adsorption values were measured on high affinity albumin-heparin conjugate pretreated surfaces. Less AT III adsorption was found on nonfractionated albumin-heparin conjugate preadsorbed surfaces. AT III adsorption could also be detected on low affinity conjugate and albu...

  7. Albumin testing in urine using a smart-phone

    OpenAIRE

    Coskun, Ahmet F.; Nagi, Richie; Sadeghi, Kayvon; Phillips, Stephen; Ozcan, Aydogan

    2013-01-01

    We demonstrate a digital sensing platform, termed Albumin Tester, running on a smart-phone that images and automatically analyses fluorescent assays confined within disposable test tubes for sensitive and specific detection of albumin in urine. This light-weight and compact Albumin Tester attachment, weighing approximately 148 grams, is mechanically installed on the existing camera unit of a smart-phone, where test and control tubes are inserted from the side and are excited by a battery powe...

  8. Experimental investigation of the serum albumin fascia microstructure

    Science.gov (United States)

    Buzoverya, M. E.; Shcherbak, Yu. P.; Shishpor, I. V.

    2012-09-01

    The results of theoretical and experimental investigation of biological liquids are reported. Structural effects observed in fascias are considered with account of the molecular features of albumin and the concept of supramolecular organization of polymers. It is revealed that the morphology of human serum albumin fascias depends on the concentration and quality of the solvent. It is shown that the water-salt fascias of albumin are more structured than water solutions with the same concentration.

  9. Treatment of twin-twin transfusion syndrome by fetoscopic laser photocoagulation

    Institute of Scientific and Technical Information of China (English)

    劉子建; 梁德楊; 馮德源; 梁子昂

    2004-01-01

    @@ Twin-twin transfusion syndrome (TTTS) is a serious obstetric complication, occurring in about 15% of monochorionic (MC) twin pregnancies. If untreated, the prognosis is poor, with an overall perinatal mortality of 80%.1 It is now clear that TTTS is the result of an unbalanced unidirectional blood flow through placental arteriovenous anastomoses (also termed deep anastomoses) between the two fetal circulations.2 The donor twin progressively becomes anemic, and develops growth restriction, oliguria, and oligohydramnios/anhydramnios; whereas the recipient becomes plethoric and polyuric, and develops congestive heart failure, cardiomegaly, polyhydramnios and fetal hydrops. Preterm labor is common because of gross polyhydramnios, and further deteriorations will lead to intrauterine death of both twins.

  10. Diabetes and perinatal mortality in twin pregnancies.

    Directory of Open Access Journals (Sweden)

    Zhong-Cheng Luo

    Full Text Available BACKGROUND: Diabetes in pregnancy has been associated with a paradoxically reduced risk of neonatal death in twin pregnancies. Risk "shift" may be a concern in that the reduction in neonatal deaths may be due to an increase in fetal deaths (stillbirths. This study aimed to clarify the impact of diabetes on the risk of perinatal death (neonatal death plus stillbirth in twin pregnancies. METHODS: This was a retrospective cohort study of twin births using the largest available dataset on twin births (the U.S. matched multiple birth data 1995-2000; 19,676 neonates from diabetic pregnancies, 541,481 from non-diabetic pregnancies. Cox proportional hazard models were applied to estimate the adjusted hazard ratios (aHR of perinatal death accounting for twin cluster-level dependence. RESULTS: Comparing diabetic versus non-diabetic twin pregnancies, overall perinatal mortality rate was counterintuitively lower [2.1% versus 3.3%, aHR 0.70 (95% confidence intervals 0.63-0.78]. Individually, both stillbirth and neonatal mortality rates were lower in diabetic pregnancies, but we identified significant differences by gestational age and birth weight. Diabetes was associated with a survival benefit in pregnancies completed before 32 weeks [aHR 0.55 (0.48-0.63] or with birth weight =2500 g [aHR 2.20 (1.55-3.13]. CONCLUSIONS: Diabetes in pregnancy appears to be "protective" against perinatal death in twin pregnancies ending in very preterm or very low birth weight births. Prospective studies are required to clarify whether these patterns of risk are real, or they are artifacts of unmeasured confounders. Additional data correlating these outcomes with the types of diabetes in pregnancy are also needed to distinguish the effects of pre-gestational vs. gestational diabetes.

  11. Interaction of Nicotine and Bovine Serum Albumin

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The binding of nicotine to bovine serum albumin (BSA) was studied by UV absorption, fluorescence, and 1H NMR methods. With the addition of nicotine, the absorption band of BSA at about 210 nm decreased gradually, moved to longer wavelengths, and narrowed. BSA fluorescence of tryptophan residue was quenched by nicotine. The 1H NMR peaks of nicotine moved to downfield by the addition of BSA. The experimental results showed that nicotine was capable of binding with BSA to form a 1:1 complex. BSA's high selectivity for nicotine binding suggests a unique role for this protein in the detoxification and/or transport of nicotine.

  12. Photodynamically generated bovine serum albumin radicals

    DEFF Research Database (Denmark)

    Silvester, J A; Timmins, G S; Davies, Michael Jonathan

    1998-01-01

    Porphyrin-sensitized photoxidation of bovine serum albumin (BSA) results in oxidation of the protein at (at least) two different, specific sites: the Cys-34 residue giving rise to a thiyl radical (RS.); and one or both of the tryptophan residues (Trp-134 and Trp-214) resulting in the formation...... of tertiary carbon-centred radicals and disruption of the tryptophan ring system. In the case of porphyrins such as hematoporphyrin, which bind at specific sites on BSA, these species appear to arise via long-range transfer of damage within the protein structure, as the binding site is some distance from...

  13. The morphology of the sella turcica in monozygotic twins

    DEFF Research Database (Denmark)

    Brock-Jacobsen, Mette T; Pallisgaard, Carsten; Kjaer, Inger

    2009-01-01

    of 42 twin pairs (18 male and 24 female pairs, aged 18-23 years) comprised the material. Sella turcica measurements from non-twins aged 6-21 years were used as normal reference. Length, depth and diameter of the sella turcica were measured and controlled by re-measurements. Pearson's correlation...... coefficient was used for comparison of individuals within twin pairs. For comparison of twins and non-twins, normal standard values for length, depth and diameter were subtracted from the twin values. For the mean values of these differences, confidence limits p values and t values were calculated. The study...

  14. Sonographic monitoring of complications and anomalies in twin gestations

    International Nuclear Information System (INIS)

    One hundred sixty-eight twin gestations were evaluated to assess the role of US in the diagnosis of obstetric complications and anomalies. US revealed the following complications: symptomatic polyhydramnios (eight cases), myomas (seven), placenta previa (three), and abruption (five). Fetal anomalies included twin-twin transfusion syndrome (two), acardiac anomaly (two), chromosomal abnormality (two), anencephaly (one), hydrocephaly (one), and conjoined twins (two). In 26 gestations intrauterine fetal demise or neonatal death involved one or both twins for a total of 42 deaths, constituting a mortality of 12.5%. No maternal deaths occurred. The impact of sonographic monitoring on the obstetric management of twin gestations is emphasized

  15. Smartphone based point-of-care detector of urine albumin

    Science.gov (United States)

    Cmiel, Vratislav; Svoboda, Ondrej; Koscova, Pavlina; Provaznik, Ivo

    2016-03-01

    Albumin plays an important role in human body. Its changed level in urine may indicate serious kidney disorders. We present a new point-of-care solution for sensitive detection of urine albumin - the miniature optical adapter for iPhone with in-built optical filters and a sample slot. The adapter exploits smart-phone flash to generate excitation light and camera to measure the level of emitted light. Albumin Blue 580 is used as albumin reagent. The proposed light-weight adapter can be produced at low cost using a 3D printer. Thus, the miniaturized detector is easy to use out of lab.

  16. Changes in parasite transmission stage excretion after pheasant release.

    Science.gov (United States)

    Villanúa, D; Acevedo, P; Höfle, U; Rodríguez, O; Gortázar, C

    2006-09-01

    The production of parasite transmission stages was investigated in the faeces of 77 farm-bred ring-necked pheasants (Phasianus colchicus). Coccidian oocysts (Eimeria sp.), and nematode eggs (Heterakis sp., and Capillaria-like eggs) were recovered before and after release but all birds were treated prior to release. Treatment with fenbendazole significantly reduced the abundance of transmission-stage excretion for all parasites, and reduced the prevalence in the case of Eimeria sp. and Heterakis sp. Nonetheless, a significant increase in the excretion abundance for all parasites and in the prevalence of Eimeria sp. and Heterakis sp. was found after release. Eggs of Ascaridia sp. were found only after releasing, suggesting infection ocurred in the wild. A negative relationship was found between the pheasant body condition and Heterakis excretion abundance and a higher abundance of Capillaria sp. eggs in female birds. No significant relationship was found between parasite excretion abundance and pheasant survival. Despite this, results suggest that an increase in the excretion of parasite transmission stages follows the release of captive pheasants into the wild. This can in part explain restocking failures, but also means that autochtonous free-living birds may become exposed to new and potentially harmful pathogens. To avoid these risks it is proposed that improved prophylactic measures should be taken. PMID:16923277

  17. Short communication: Evaluation of nitrogen excretion equations from cattle.

    Science.gov (United States)

    Johnson, A C B; Reed, K F; Kebreab, E

    2016-09-01

    Nitrogen excretion in dairy manure is a precursor for N2O and NH3 formation in livestock housing, manure storage facilities, and after manure is applied to land. Nitrous oxide is a major contributor to greenhouse gas emissions, and reducing N output from dairy production facilities can reduce the amount of anthropogenic N2O entering the atmosphere. The objective of the study was to conduct a comprehensive evaluation of extant prediction models for N excretion in feces and urine using extensive literature data. A total of 45 N excretion equations were evaluated for lactating cows, heifers, and nonlactating cows and steers. These equations were evaluated with 215 treatment means from 69 published studies collected over 20 yr from 1995 to 2015. Two evaluation methods were used: the root mean square prediction error and the concordance correlation coefficient. Equations constructed using a more rigorous development process fared better than older extant equations. Equations for heifers and nonlactating cows had greater error of prediction compared with equations used for lactating cows. This could be due to limited amount of data available for construction and evaluation of the equations. Urinary N equations had greater prediction errors than other forms of excretion, possibly due to high variability in urinary N excretion and challenges in urine collection. Fecal N equations had low error bias and reached an acceptable level of precision and accuracy. PMID:27320670

  18. Interactions of aptamers with sera albumins

    Science.gov (United States)

    Cortez, Célia Martins; Silva, Dilson; Silva, Camila M. C.; Missailidis, Sotiris

    2012-09-01

    The interactions of two short aptamers to human and bovine serum albumins were studied by fluorescence spectroscopic techniques. Intrinsic fluorescence of BSA and HSA were measured by selectively exciting their tryptophan residues. Gradual quenching was observed by titration of both proteins with aptamers. Aptamers are oligonucleic acid or peptide molecules that bind a specific target and can be used for both biotechnological and clinical purposes, since they present molecular recognition properties like that commonly found in antibodies. Two aptamers previously selected against the MUC1 tumour marker were used in this study, one selected for the protein core and one for the glycosylated MUC1. Stern-Volmer graphs were plotted and quenching constants were estimated. Plots obtained from experiments carried out at 25 °C and 37 °C showed the quenching of fluorescence of by aptamers to be a collisional phenomenon. Stern-Volmer constants estimated for HSA quenched by aptamer A were 1.68 × 105 (±5 × 103) M-1 at 37 °C, and 1.37 × 105 (±103) M-1 at 25 °C; and quenched by aptamer B were 1.67 × 105 (±5 × 103) M-1 at 37 °C, and 1.32 × 105 (±103) M-1 at 25 °C. Results suggest that the primary binding site for aptamers on albumin is close to tryptophan residues in sub domain IIA.

  19. Binding of anandamide to bovine serum albumin

    DEFF Research Database (Denmark)

    Bojesen, I.N.; Hansen, Harald S.

    2003-01-01

    with anandamide bound to BSA inside resealed human red cell membranes at low molar ratios below one. Data were obtained at 0°C, 10°C, 23°C, and 37°C. The equilibrium dissociation constant (K ) increases with temperature from 6.87 ± 0.53 nM at 0°C to 54.92 ± 1.91 nM at 37°C. Regression analyses of the data suggest......The endocannabinoid anandamide is of lipid nature and may thus bind to albumin in the vascular system, as do fatty acids. The knowledge of the free water-phase concentration of anandamide is essential for the investigations of its transfer from the binding protein to cellular membranes, because...... a water-phase shuttle of monomers mediates such transfers. We have used our method based upon the use of albumin-filled red cell ghosts as a dispersed biological "reference binder" to measure the water-phase concentrations of anandamide. These concentrations were measured in buffer (pH 7.3) in equilibrium...

  20. Isolation and characterisation of the Xenopus laevis albumin genes: loss of 74K albumin gene sequences by library amplification.

    OpenAIRE

    May, F E; Weber, R.; Westley, B. R.

    1982-01-01

    The blood of the frog X.laevis contains 2 albumins of 68,000 and 74,000 daltons which are encoded in the liver by two related mRNAs. When an amplified X.laevis DNA library was screened with cloned albumin cDNA only 68,000 dalton albumin gene sequences were isolated. Hybridisation of the albumin cDNA to Southern-blots of Eco R1 digested X.laevis DNA showed that the sequences present in the recombinants did not account for all the fragments which hybridised on the Southern-blots. This indicated...

  1. Plasma-to-ascitic fluid transport rate of albumin in patients with decompensated cirrhosis. Relation to intraperitoneal albumin

    DEFF Research Database (Denmark)

    Henriksen, Jens Henrik Sahl; Ring-Larsen, H; Lassen, N A;

    1983-01-01

    Albumin-kinetics and haemodynamic studies were performed in 20 patients with decompensated liver cirrhosis in order to improve the knowledge on genesis and perpetuation of hepatic ascites, especially with respect to determinants of intraperitoneal protein. A positive relationship was found between...... the plasma-to-peritoneal transport rate of albumin (index of 'lymph-imbalance') and the mass of intraperitoneal albumin (rlog = 0.82, P less than 0.001), indicating a significant role of 'lymph-imbalance' to sequestration of protein in the peritoneal cavity. Ascitic fluid albumin concentration was on...

  2. Internal dosimetry of plutonium using the late urinary excretion.

    Science.gov (United States)

    Sharma, R C; Abani, M C

    2000-10-01

    An attempt has been made to standardize the methodology of internal dose computation from the late urinary excretion data. The methodology was selected keeping in mind the most recent ICRP publications and the results of internal dosimetry intercomparison studies reported in literature. The key element of this methodology is the PC-based computational software LUDEP 2.05, which implements the new model of the human respiratory tract. Late urinary excretion data of three male subjects involved in accidental intakes of plutonium aerosols more than 25 years ago were interpreted in terms of intakes and internal doses with the aid of the standardized methodology. An important implication of this work is that late urinary excretion data of the occupational workers of any plutonium handling facility could be used to show the compliance with the life-time dose limit.

  3. Water metabolism and modification of tritium excretion in the rat

    International Nuclear Information System (INIS)

    1. The intake and excretion of tritium were studied in rats exposed to tritiated water vapor. The metabolism of tritium was also investigated in rats given single administrations of tritiated water and in rats given daily administrations (per os or i.p.). The results were essentially in accord with those reported previously. 2. Amounts of drinking water consumed and urine excreted by rats drinking water with 0.15% saccharin were 1.5 to 2 times higher than in rats drinking tap water. The tritium activity in various tissues of rats drinking water with 0.15% saccharin decreased to about half of that of rats drinking tap water. A similar tendency was observed also in rats drinking beer. The diuretic agent sodium acetazolamide also enhanced the urinary excretion of tritium. (author)

  4. A Twin Protection Effect? Explaining Twin Survival Advantages with a Two-Process Mortality Model.

    Science.gov (United States)

    Sharrow, David J; Anderson, James J

    2016-01-01

    Twin studies that focus on the correlation in age-at-death between twin pairs have yielded important insights into the heritability and role of genetic factors in determining lifespan, but less attention is paid to the biological and social role of zygosity itself in determining survival across the entire life course. Using data from the Danish Twin Registry and the Human Mortality Database, we show that monozygotic twins have greater cumulative survival proportions at nearly every age compared to dizygotic twins and the Danish general population. We examine this survival advantage by fitting these data with a two-process mortality model that partitions survivorship patterns into extrinsic and intrinsic mortality processes roughly corresponding to acute, environmental and chronic, biological origins. We find intrinsic processes confer a survival advantage at older ages for males, while at younger ages, all monozygotic twins show a health protection effect against extrinsic death akin to a marriage protection effect. While existing research suggests an increasingly important role for genetic factors at very advanced ages, we conclude that the social closeness of monozygotic twins is a plausible driver of the survival advantage at ages <65.

  5. Twinning and de-twinning in beryllium during strain path changes

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D.W., E-mail: dbrown@lanl.gov [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Almer, J.D. [Argonne National Laboratory, Argonne, IL 60439 (United States); Clausen, B. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Mosbrucker, P.L. [Kinectrics Inc., 800 Kipling Avenue, Unit 2, Toronto, ON, Canada M8Z 5G5 (Canada); Sisneros, T.A.; Vogel, S.C. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2013-01-01

    Rolled beryllium samples in the form of rectangular parallelepipeds were deformed at strain rates of 0.001/s and 5/s through multiple strain paths. Samples were initially deformed in-plane nominally -0.22 in compression at a rate of 5/s to populate the microstructure with twins and then reoriented and deformed a second time either in the through-thickness direction or the other in-plane direction. The microstructure (texture and internal strain) were monitored through in-situ and ex-situ diffraction measurements using neutron diffraction on the HIPPO diffractometer at LANSCE, and high energy X-ray diffraction on the 1-ID-C beamline at the APS. Twin reversal is observed when the sample is reoriented and deformed a second time in the TT direction. The twin reversal is strain rate independent in contrast to the strong strain rate dependence observed during twinning in beryllium. Deformation twinning is also observed during secondary compression in the second in-plane direction, but from the current data set we cannot determine with certainty if these twins originate from the parent orientation or the twins formed during primary in-plane compression. As a whole, this data set creates a very demanding test for the development of polycrystalline plasticity models of deformation in hexagonal metals.

  6. Phenomenology of Left-Right Twin Higgs Model

    CERN Document Server

    Goh, H S; Goh, Hock-Seng; Su, Shufang

    2007-01-01

    Twin Higgs mechanism has recently been proposed to solve the ``little Hierarchy'' problem. We studied the implementation of twin Higgs mechanism in left-right models. We discussed the particle spectrum, and the collider phenomenology at the Large Hadron Collider.

  7. Phenomenology of Left-Right Twin Higgs Model

    OpenAIRE

    Goh, Hock-Seng; Su, Shufang

    2006-01-01

    Twin Higgs mechanism has recently been proposed to solve the ``little Hierarchy'' problem. We studied the implementation of twin Higgs mechanism in left-right models. We discussed the particle spectrum, and the collider phenomenology at the Large Hadron Collider.

  8. Antenatal genetic studies in twin pregnancies.

    Science.gov (United States)

    Redwine, F O; Cruikshank, D P; Brown, J

    1984-01-01

    The diagnosis of multiple gestation at the time of genetic amniocentesis is a routine occurrence. In a combined series of 2765 patients referred for antenatal genetic studies from the Medical College of Virginia and the University of Iowa, 34 twin pregnancies were encountered (1.2%). Twenty-six of the patients with twins were referred for advanced maternal age. The other indications were previous neural tube defects (1), previous trisomy 21 (2), known carriers of Tay Sachs disease (2), previous Turner's syndrome (1), family history of trisomy 21 (1), and one pregnancy was referred because of an abnormal ultrasound. Amniocentesis procedures, outcome of the twin pregnancies, and genetic counseling issues, are discussed. PMID:6741416

  9. Plasmonic twinned silver nanoparticles with molecular precision

    Science.gov (United States)

    Yang, Huayan; Wang, Yu; Chen, Xi; Zhao, Xiaojing; Gu, Lin; Huang, Huaqi; Yan, Juanzhu; Xu, Chaofa; Li, Gang; Wu, Junchao; Edwards, Alison J.; Dittrich, Birger; Tang, Zichao; Wang, Dongdong; Lehtovaara, Lauri; Häkkinen, Hannu; Zheng, Nanfeng

    2016-09-01

    Determining the structures of nanoparticles at atomic resolution is vital to understand their structure-property correlations. Large metal nanoparticles with core diameter beyond 2 nm have, to date, eluded characterization by single-crystal X-ray analysis. Here we report the chemical syntheses and structures of two giant thiolated Ag nanoparticles containing 136 and 374 Ag atoms (that is, up to 3 nm core diameter). As the largest thiolated metal nanoparticles crystallographically determined so far, these Ag nanoparticles enter the truly metallic regime with the emergence of surface plasmon resonance. As miniatures of fivefold twinned nanostructures, these structures demonstrate a subtle distortion within fivefold twinned nanostructures of face-centred cubic metals. The Ag nanoparticles reported in this work serve as excellent models to understand the detailed structure distortion within twinned metal nanostructures and also how silver nanoparticles can span from the molecular to the metallic regime.

  10. Prevention of preterm delivery in twin pregnancy

    DEFF Research Database (Denmark)

    Rode, Line; Tabor, Ann

    2014-01-01

    The incidence of twin gestation has increased markedly over the past decades, mostly because of increased use of assisted reproductive technologies. Twin pregnancies are at increased risk of preterm delivery (i.e. birth before 37 weeks of gestation). Multiple gestations therefore account for 2......-3% of all pregnancies but constitute at least 10% of cases of preterm delivery. Complications from preterm birth are not limited to the neonatal period, such as in retinopathy of prematurity, intraventricular haemorrhage, necrotising enterocolitis, respiratory disorder and sepsis; they can also constitute......, it is mandatory to evaluate the proposed treatments in randomised trials of multiple gestations. In this chapter, we describe the results of trials to prevent preterm delivery in twin pregnancies....

  11. [Risk of preterm birth in twin pregnancy].

    Science.gov (United States)

    Wilczyński, J; Nowakowska, D; Jaczewski, B; Wenerski, J; Oszukowski, P; Krasomski, G

    2000-11-01

    The aim of the study was to analyze the selected risk factors in twin pregnancies. Retrospective analysis was carried out in the Research Institute Polish Mother's Memorial Hospital (ICZMP) in Lodz and covered data from the period of time between 1989-1999. Out of 38,066 deliveries which had place in the ICZMP 538 twin pregnancies were enrolled in the study. We evaluated usual risk factors for preterm birth such as body mass index, short cervical length, beta-mimetics admission, presence of bleeding and contractions as well as socio-demographical characteristics such as age, parity, martial status and educational level. Univariate analysis and ?2 test were preformed. Odds ratios and 95% confidence intervals were calculated. For multivariate analysis logistic regression model was used. Most of the risk factors for preterm birth were not significantly associated with spontaneous preterm birth of twins. PMID:11216165

  12. Solar twins in the ELODIE archive

    CERN Document Server

    Mahdi, Dhiaa; Blanco-Cuaresma, Sergi; Chemin, Laurent

    2016-01-01

    A large dataset of ~2800 spectra extracted from the ELODIE archive was analysed in order to find solar twins. A list of stellar spectra closely resembling the spectrum of the Sun was selected by applying a purely differential method, directly on the fluxes. As solar reference, 18 spectra of asteroids, Moon and blue sky were used. Atmospheric parameters and differential abundances of 8 chemical elements were determined for the solar twin candidates, after a careful selection of appropriate lines. The Li feature of the targets was investigated and additional information on absolute magnitude and age was gathered from the literature. HIP076114 (HD138573) is our best twin candidate, looking exactly like the Sun in all these properties.

  13. Aging and communication in the twin paradox

    Science.gov (United States)

    de Wolf, David A.

    2016-11-01

    The twin paradox of the special theory of relativity has given rize to a large body of literature discussing its implications. In its standard form, the traveler changes velocity only at the destination of the trip, so that he appears to perceive an improbably instantaneous and non-continuous change in age of the stationary twin. In this work, a smooth velocity/acceleration profile is used that allows the abrupt velocity-change case as a limit. All gravitational effects are ignored in this treatment. Aside from mutual perception of simultaneous clock times in an accelerating frame, constant communication of clock times between the twins by means of (digital) light signals is shown to be possible, in principle if not in practice.

  14. Twin and Mirror Symmetries from Presymmetry

    CERN Document Server

    Matute, Ernesto A

    2011-01-01

    We argue that presymmetry, a hidden predynamical electroweak quark-lepton symmetry that explains the fractional charges and triplication of families, must be extended beyond the Standard Model as to have a residual presymmetry that embraces partner particles and includes the strong sector, so accounting for the twin or mirror partners proposed to alleviate the naturalness problem of the weak scale. It leads to the full duplication of fermions and gauge bosons of the Standard Model independently of the ultraviolet completion of the theory, even if the Higgs particle is discarded by experiment, which adds robustness to twin and mirror symmetries. The established connection is so strongly motivated that the search for twin or mirror matter becomes the possible test of presymmetry. If the physics beyond the Standard Model repairs its left-right asymmetry, mirror symmetry should be the one realized in nature.

  15. Time, Topology and the Twin Paradox

    CERN Document Server

    Luminet, J -P

    2009-01-01

    The twin paradox is the best known thought experiment associated with Einstein's theory of relativity. An astronaut who makes a journey into space in a high-speed rocket will return home to find he has aged less than a twin who stayed on Earth. This result appears puzzling, since the situation seems symmetrical, as the homebody twin can be considered to have done the travelling with respect to the traveller. Hence it is called a "paradox". In fact, there is no contradiction and the apparent paradox has a simple resolution in Special Relativity with infinite flat space. In General Relativity (dealing with gravitational fields and curved space-time), or in a compact space such as the hypersphere or a multiply connected finite space, the paradox is more complicated, but its resolution provides new insights about the structure of spacetime and the limitations of the equivalence between inertial reference frames.

  16. Aging and communication in the twin paradox

    CERN Document Server

    de Wolf, David A

    2016-01-01

    The twin paradox of the special theory of relativity has given rise to a large body of literature discussing its implications. In its standard form, the traveler changes velocity only at the destination of the trip, so that he appears to perceive an improbably instantaneous and non-continuous change in age of the stationary twin. In this work, a smooth velocity/acceleration profile is used that allows the abrupt velocity-change case as a limit. All gravitational effects are ignored in this treatment. Aside from mutual perception of simultaneous clock times in an accelerating frame, constant communication of clock times between the twins by means of (digital) light signals is shown to be possible, in principle if not in practice.

  17. A Danish Twin Study of Schizophrenia Liability

    DEFF Research Database (Denmark)

    Kläning, Ulla; Trumbetta, Susan L; Gottesman, Irving I;

    2016-01-01

    We studied schizophrenia liability in a Danish population-based sample of 44 twin pairs (13 MZ, 31 DZ, SS plus OS) in order to replicate previous twin study findings using contemporary diagnostic criteria, to examine genetic liability shared between schizophrenia and other disorders, and to explore...... whether variance in schizophrenia liability attributable to environmental factors may have decreased with successive cohorts exposed to improvements in public health. ICD-10 diagnoses were determined by clinical interview. Although the best-fitting, most parsimonious biometric model of schizophrenia...... liability specified variance attributable to additive genetic and non-shared environmental factors, this model did not differ significantly from a model that also included non-additive genetic factors, consistent with recent interview-based twin studies. Schizophrenia showed strong genetic links to other...

  18. Fetal Brain Injury in Survivors of Twin Pregnancies Complicated by Demise of One Twin: A Review.

    Science.gov (United States)

    Mackie, Fiona L; Morris, R Katie; Kilby, Mark D

    2016-06-01

    Perinatal mortality is increased considerably in multiple pregnancies compared to singleton pregnancies, with single intrauterine fetal demise (sIUFD) presenting a rare but unique perinatal problem. Monochorionic pregnancies are at particular risk of sIUFD due to bidirectional inter-twin placental vascular anastomoses. The resulting inter-twin blood flow can become unbalanced, causing acute and chronic inter-twin transfusion and profound anemia secondary to fetal exsanguination into the low-pressure circulation of the dead fetus. If the sIUFD occurs after 14 weeks' gestation it is believed to have the most significant effect on the continuing pregnancy as the co-twin is at increased risk of preterm delivery, long-term neurological complications, and death. This article will focus on fetal brain injury in the surviving co-twin in the case of sIUFD, as it is the most common kind of injury in sIUFD, and one which concerns parents and may be the basis for terminating the pregnancy. We will outline how these brain injuries are thought to occur and describe potential pathophysiological mechanisms. We will discuss risk factors for brain injury in cases of sIUFD, including: chorionicity, cause of the sIUFD (spontaneous or secondary to an underlying pathological process such as twin-to-twin transfusion syndrome), gestation of delivery and how to prevent brain injury in the co-twin. We also review modes of imaging, discuss the difficulties in predicting the long-term outcome for co-twin survivors, and highlight the dearth of research in this area. PMID:27203608

  19. Infant mortality in twin pregnancies following in-utero demise of the co-twin

    Institute of Scientific and Technical Information of China (English)

    Boubakari Ibrahimou; Hamisu M Salihu; Muktar H Aliyu; Gary English; Getachew Dagne

    2015-01-01

    Objective:To assess whether conversion from twin to singleton pregnancy following the demise of a co-twin influences survival.Methods:This retrospective study compared the risk for neonatal, post-neonatal and infant death for converted co-twins versus unconverted co-twins using the US matched multiple file dataset for the period 1995-2000. We also examined the same risks for converted versus same-quantile co-twins, hazard ratios (HR) and 95% confidence intervals (CI) were computed using Cox Proportional Hazards models.Results:The risk for neonatal (HR=0.18, 95%CI: 0.09-0.34 andHR=0.69, 95%CI: 0.50- 0.96) and infant death (HR=0.22, 95%CI: 0.12-0.42 andHR=0.57, 95%CI: 0.42-0.77) were significantly lower for converted twins than for unconverted twins and same-quantile twins, respectively. For black compared to white, the risk for post-neonatal death increased by 89% (HR=1.89, 95%CI= 1.03, 3.48), and 79% (HR=1.79, 95%CI=1.53, 2.09) for convertedvs. unconverted and convertedvs. same-quantile, respectively. For converted black, the risk for neonatal death decreased by 17% (HR=0.83, 95%CI=0.73-0.93) as compared to unconverted.Conclusions: Risks for all mortality types were lower among converted co-twins than their unconverted or same-quantile counterparts. The lower neonatal and higher post-neonatal mortality among black require future research.

  20. Urticaria in Monozygotic and Dizygotic Twins

    Directory of Open Access Journals (Sweden)

    Simon Francis Thomsen

    2012-01-01

    Full Text Available Aim. To identify risk factors for urticaria, to determine the relative proportion of the susceptibility to urticaria that is due to genetic factors in an adult clinical twin sample, and to further determine whether the genetic susceptibility to urticaria overlaps with the genetic susceptibility to atopic diseases. Methods. A total of 256 complete twin pairs and 63 single twins, who were selected from sibships with self-reported asthma via a questionnaire survey of 21,162 adult twins from the Danish Twin Registry, were clinically interviewed about a history of urticaria and examined for atopic diseases. Data were analysed with Cox proportional hazards regression and variance components models. Results. A total of 151 individuals (26% had a history of urticaria, whereas 24 (4% had had symptoms within the past year. Female sex, HR=2.09 (1.46–2.99, P=0.000; hay fever, HR=1.92 (1.36–2.72, P=0.000; and atopic dermatitis, HR=1.44 (1.02–2.06, P=0.041 were significant risk factors for urticaria. After adjustment for sex and age at onset of urticaria in the index twin, the risk of urticaria was increased in MZ cotwins relative to DZ cotwins, HR=1.42 (0.63–3.18, P=0.394. Genetic factors explained 45% (16–74%, P=0.005, of the variation in susceptibility to urticaria. The genetic correlation between urticaria and hay fever was 0.45 (0.01–0.89, P=0.040. Conclusions. Susceptibility to urticaria is partly determined by genetic factors. Urticaria is more common in women, and in subjects with hay fever and atopic dermatitis, and shares genetic variance with hay fever.

  1. The twin paradox in the presence of gravity

    CERN Document Server

    Gasperini, M

    2014-01-01

    Conventional wisdom, based on kinematic (flat-space) intuition, tell us that a static twin is aging faster than his traveling twin brother. However, such a situation could be exactly inverted if the two twins are embedded in an external gravitational field, and if the (dynamical) distortion of the space-time geometry, due to gravity, is strong enough to compensate the kinematic effect of the relative twin motion.

  2. A note on twin-singleton differences in asthma

    DEFF Research Database (Denmark)

    Thomsen, Simon Francis; Kyvik, Kirsten Ohm; Backer, Vibeke

    2008-01-01

    Twins constitute a valuable resource for genetic studies of asthma. However, critics argue that twins are 'special' in terms of prenatal environment and upbringing and therefore nonrepresentative. In respect to asthma a small range of studies report differential morbidity in twins compared...... with singletons. We review some of the possible explanations for these findings and conclude that results from twin studies of asthma can be extrapolated to the general population....

  3. Occurrence of twin embryos in the eastern bluebird

    OpenAIRE

    Bailey, Robyn L.; Gerald E. Clark

    2014-01-01

    We report the first record of presumed twinning in eastern bluebird (Sialia sialis) and provide a review of previously reported twinning events in wild birds. A nest containing twin eastern bluebird nestlings was monitored in 2013 in central Pennsylvania and reported to the Cornell Lab of Ornithology’s NestWatch program, a national program where volunteers submit data on wild nesting birds. A presumed double-yolked egg of a free-living eastern bluebird pair hatched successfully, and twin nest...

  4. Prenatal diagnosis of pygopagus tetrapus parasitic twin: case report

    OpenAIRE

    Ceylan Yavuz; Aslan Halil; Gul Ahmet

    2004-01-01

    Abstract Background Asymmetric and parasitic conjoined twins are rarer anomalies of monochorionic monoamniotic twins, consisting of an incomplete twin attached to the fully developed body of the co-twin. Case presentation A 30-year-old multigravid woman referred to maternal fetal unit due to polyhydramnios at 28th week of gestation. Sonographic examination revealed a single fetus and polyhydramnios with amniotic fluid index 30 cm. The fetus had normal apparent single head, spine, thorax, abdo...

  5. Nucleotide sequence of cloned rat serum albumin messenger RNA.

    OpenAIRE

    Sargent, T D; Yang, M; Bonner, J.

    1981-01-01

    The nucleotide sequences of the recombinant DNA inserts of three bacterial plasmid clones containing nearly all of the rat serum albumin mRNA have been determined. A statistical analysis of the nucleotide sequence reveals a pattern of repeated internal homology that confirms the "intragenic triplication" model of albumin evolution.

  6. [Pulsed radiolysis of aqueous solutions of serum albumin containing naphthoquinones].

    Science.gov (United States)

    Pribush, A G; Savich, A V

    1987-01-01

    As was shown by the pulse radiolysis method the simultaneous presence of naphthoquinone and human serum albumin molecules in an aqueous solution leads to the adsorption of the former on the surface of the latter. It is suggested that in these conditions the protein tertiary structure changes. New conformation reduces the reactivity of albumin toward the hydrated electron. PMID:3628723

  7. Interaction of indomethacin with adult human albumin and neonatal serum

    DEFF Research Database (Denmark)

    Honoré, B; Brodersen, R; Robertson, A

    1983-01-01

    The binding of indomethacin to albumin was investigated at 37 degrees C, pH 7.4. The first stoichiometric binding constant is 2.5 X 10(5) M-1. Indomethacin utilizes both the bilirubin and diazepam binding functions equally. The effect on bilirubin binding to albumin is negligible at therapeutic...

  8. Serum albumin--a non-saturable carrier

    DEFF Research Database (Denmark)

    Brodersen, R; Honoré, B; Larsen, F G

    1984-01-01

    The shape of binding isotherms for sixteen ligands to human serum albumin showed no signs of approaching saturation at high ligand concentrations. It is suggested that ligand binding to serum albumin is essentially different from saturable binding of substrates to enzymes, of oxygen to haemoglobi...

  9. Investigation of bovine serum albumin glycation by THz spectroscopy

    Science.gov (United States)

    Cherkasova, Olga P.; Nazarov, Maxim M.; Shkurinov, Alexander P.

    2016-04-01

    Protein glycation is accelerated under hyperglycemic conditions resulting to loss in the structure and biological functions of proteins. The transmission THz spectroscopy has been used for measuring of bovine serum albumin glycation dynamics. It was found that amplitude of albumin THz absorption depends on type of sugars and incubation time.

  10. Preliminary design of twin-cylinder engines

    OpenAIRE

    Louvigny, Yannick

    2008-01-01

    This report deals with the preliminary design of a twin-cylinder engine. The goal of the work is not to make the detailed design of the engine but to draw the main characteristics of each kind of engine and to investigate which configuration of twin-cylinder engine matches in the best way to given requirements. A simple model is developed from the motion equations of the rotating and oscillating parts of piston engine. This model allows calculating the values of the inertia forces and mom...

  11. Breastfeeding twins and higher-order multiples.

    Science.gov (United States)

    Gromada, K K; Spangler, A K

    1998-01-01

    The benefits of breastfeeding for pre-term and full-term infants are well documented. Breastfeeding facilitates maternal-infant attachment, provides optimal infant nutrition and immunologic protection, and minimizes economic impact. These benefits are multiplied with twins and higher-order multiples, who often are born at risk. Supporting a mother as she initiates and continues to breastfeed one infant requires specific knowledge and skills. Health professionals need additional knowledge and skills if they are to provide appropriate assessment, intervention, and support when a mother breastfeeds twins or higher-order multiples. PMID:9684207

  12. Conjoined twins: scientific cinema and Pavlovian physiology.

    Science.gov (United States)

    Krementsov, Nikolai

    2015-01-01

    Through the lens of a 1957 documentary film, "Neural and humoral factors in the regulation of bodily functions (research on conjoined twins)," produced by the USSR Academy of Medical Sciences, this essay traces the entwined histories of Soviet physiology, studies of conjoined twins and scientific cinema. It examines the role of Ivan Pavlov and his students, including Leonid Voskresenkii, Dmitrii Fursikov and Petr Anokhin, in the development of "scientific film" as a particular cinematographic genre in Soviet Russia and explores numerous puzzles hidden behind the film's striking visuals. PMID:26601729

  13. Conjoined twins: scientific cinema and Pavlovian physiology.

    Science.gov (United States)

    Krementsov, Nikolai

    2015-01-01

    Through the lens of a 1957 documentary film, "Neural and humoral factors in the regulation of bodily functions (research on conjoined twins)," produced by the USSR Academy of Medical Sciences, this essay traces the entwined histories of Soviet physiology, studies of conjoined twins and scientific cinema. It examines the role of Ivan Pavlov and his students, including Leonid Voskresenkii, Dmitrii Fursikov and Petr Anokhin, in the development of "scientific film" as a particular cinematographic genre in Soviet Russia and explores numerous puzzles hidden behind the film's striking visuals.

  14. Two New Variations on the Twin Pseudoparadox

    CERN Document Server

    Leblond, Jean Marc Levy

    2015-01-01

    Two new scenarios are proposed which generalize the standard story leading to the pseudoparadox of the Einsteinian relativistic twins, thereby enabling some deeper understanding. First, the fable by Aesop 'The Hare and the Tortoise' is considered in the light of Einsteinian chronogeometry. It is then shown that the Hare, while arriving later than the Tortoise, may still be the winner of the race (or at least may consider itself to be). Second, the situation is considered where the twin initially left at home decides to catch up his brother during his travel. Can they meet so that they may celebrate a common anniversary and recover the same age?

  15. Planets and satellites: tectonic twins

    Science.gov (United States)

    Kochemasov, G. G.

    2015-10-01

    There are only three solid planet-satellite pairs in the Solar system: Earth -Moon, Mars -Phobos, Pluto - Charon. For the first two pairs tectonic analogies were shown and explained by moving them in one circumsolar orbit. As it is known from the wave planetology [3, 4, 6], "orbits make structures". For the third pair the same was stated as a prediction based on this fundamental rule. Global tectonic forms of wave origin appear in cosmic bodies because they move in keplerian orbits with periodically changing accelerations. Warping bodies waves have a stationary character and obeying wave harmonics lengths. Starting from the fundamental 2πR-long wave 1 making the ubiquitous tectonic dichotomy (two-face appearance) warping wave lengths descend along harmonics. Very prominent along with the wave 1 are waves 2 responsible for tectonic sectoring superimposed on the wave 1 segments. Practically all bodies have traces of shorter waves making numerous polygons (rings) often confused with impact craters. Earth and the Moon moving in one circumsolar orbit both are distorted by wave 1, wave 2 and wave 4 features aligned along extent tectonic lines [4, 5]. At Earth they are: Pacific Ocean (2πR-structure) and Indian Ocean (πR-structure) from both ends with Malay Archipelago (πR/4-structure) in the middle. At Moon they are: Procellarum Ocean (2πR) and SPA Basin (πR) from ends and Mare Orientale (πR/4) in the middle. A regular disposition is surprising. Both Oceans and Basin occur on opposite hemispheres, lying in the middle both ring structures occur in the boundary between two hemispheres and are of the same relative size. These triads stretch along lines parallel to the equator (Earth) and with the angle about 30 degrees to it (Moon) indicating at a different orientation of the rotation axes in the ancient time [2]. On the whole, one could speak about a "lunar mould" of Earth [5] (Fig. 1-3). Another tectonic twin is the pair Mars -Phobos. Both bodies sharing one

  16. Twin pregnancy possibly associated with high semen quality

    DEFF Research Database (Denmark)

    Asklund, Camilla; Jensen, Tina Kold; Jørgensen, Niels;

    2007-01-01

    BACKGROUND: Recent studies found an association between a long waiting time to pregnancy (TTP) and reduced probability of twinning and a reduced dizygotic (DZ) twinning rate in subfertile men. However, it remains unsolved whether semen quality is associated with twin offspring. We therefore studied...

  17. Ghrelin binding to serum albumin and its biological impact.

    Science.gov (United States)

    Lufrano, Daniela; Trejo, Sebastián A; Llovera, Ramiro E; Salgueiro, Mariano; Fernandez, Gimena; Martínez Damonte, Valentina; González Flecha, F Luis; Raingo, Jesica; Ermácora, Mario R; Perelló, Mario

    2016-11-15

    Ghrelin is an octanoylated peptide hormone that plays a key role in the regulation of the body weight and glucose homeostasis. In plasma, ghrelin circulates bound to larger proteins whose identities are partially established. Here, we used size exclusion chromatography, mass spectrometry and isothermal titration microcalorimetry to show that ghrelin interacts with serum albumin. Furthermore, we found that such interaction displays an estimated dissociation constant (KD) in the micromolar range and involves albumin fatty-acid binding sites as well as the octanoyl moiety of ghrelin. Notably, albumin-ghrelin interaction reduces the spontaneous deacylation of the hormone. Both in vitro experiments-assessing ghrelin ability to inhibit calcium channels-and in vivo studies-evaluating ghrelin orexigenic effects-indicate that the binding to albumin affects the bioactivity of the hormone. In conclusion, our results suggest that ghrelin binds to serum albumin and that this interaction impacts on the biological activity of the hormone. PMID:27431015

  18. Interaction of coffee compounds with serum albumins. Part II: Diterpenes.

    Science.gov (United States)

    Guercia, Elena; Forzato, Cristina; Navarini, Luciano; Berti, Federico

    2016-05-15

    Cafestol and 16-O-methylcafestol are diterpenes present in coffee, but whilst cafestol is found in both Coffea canephora and Coffea arabica, 16-O-methylcafestol (16-OMC) was reported to be specific of only C. canephora. The interactions of such compounds, with serum albumins, have been studied. Three albumins have been considered, namely human serum albumin (HSA), fatty acid free HSA (ffHSA) and bovine serum albumin (BSA). The proteins interact with the diterpenes at the interface between Sudlow site I and the fatty acid binding site 6 in a very peculiar way, leading to a significant change in the secondary structure. The diterpenes do not displace reference binding drugs of site 2, but rather they enhance the affinity of the site for the drugs. They, therefore, may alter the pharmacokinetic profile of albumin - bound drugs.

  19. Micropinocytic ingestion of glycosylated albumin by isolated microvessels: possible role in pathogenesis of diabetic microangiopathy.

    OpenAIRE

    Williams, S K; Devenny, J J; Bitensky, M W

    1981-01-01

    Microvessels isolated from rat epididymal fat exhibit differential vesicular ingestion rates for unmodified and non-enzymatically glycosylated rat albumin. While unmodified rat albumin is excluded from ingestion by endothelial micropinocytic vesicles, glycosylated albumin is avidly taken up by endocytosis. Interaction of albumin and glycosylated albumin with endothelium was studied with a double-label fluorescence assay of micropinocytosis. When glycosylated albumin was present at a concentra...

  20. Renal Type A Intercalated Cells Contain Albumin in Organelles with Aldosterone-Regulated Abundance

    OpenAIRE

    Jensen, Thomas Buus; Cheema, Muhammad Umar; Szymiczek, Agata; Damkier, Helle Hasager; Praetorius, Jeppe

    2015-01-01

    Albumin has been identified in preparations of renal distal tubules and collecting ducts by mass spectrometry. This study aimed to establish whether albumin was a contaminant in those studies or actually present in the tubular cells, and if so, identify the albumin containing cells and commence exploration of the origin of the intracellular albumin. In addition to the expected proximal tubular albumin immunoreactivity, albumin was localized to mouse renal type-A intercalated cells and cells i...

  1. Toxicity of Magnetic Albumin Microspheres Bearing Adriamycin

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Magnetic albumin microspheres bearing adriamycin (ADM-MAM) is a novel chemotherapeutic compound with site-specific drug delivery characteristics. The acute and subacute toxic tests of the compound, local irritating test and anaphylactic test were performed on mice and guinea pigs. The results showed there was no macroscopically and microscopically direct cytotoxic injuries of the compound to the animal organs or to the cells. The LD50 value of the compound was higher than that of the single used adriamycin, indicating that the compound was less toxic than the single adriamycin and quite safe in its therapeutic dosage. Furthermore, there was also no side effects or toxic reactions to be observed on clinical patients with advanced carcinoma or gastric cancer.

  2. Aggregation and fibrillation of bovine serum albumin

    DEFF Research Database (Denmark)

    Holm, NK; Jespersen, SK; Thomassen, LV;

    2007-01-01

    The all-alpha helix multi-domain protein bovine serum albumin (BSA) aggregates at elevated temperatures. Here we show that these thermal aggregates have amyloid properties. They bind the fibril-specific dyes Thioflavin T and Congo Red, show elongated although somewhat worm-like morphology...... and changes in morphology suggest the existence of different aggregate species. Although beta-sheet content increases from 0 to ca. 40% upon aggregation, the aggregates retain significant amounts of alpha-helix structure, and lack a protease-resistant core. Thus BSA is able to form well-ordered beta...... significant amounts of alpha-helix, highlights the universality of the fibrillation mechanism. However, the presence of non-beta-sheet structure may influence the final fibrillar structure and could be a key component in aggregated BSA's lack of cytotoxicity....

  3. Campylobacter infections in fattening pigs; Excretion pattern and genetic diversity

    NARCIS (Netherlands)

    Weijtens, M.J.B.M.; Reinders, R.D.; Urlings, H.A.P.; Plas, J. van der

    1999-01-01

    The excretion of campylobacter by eight individually housed fattening pigs was monitored during 15 weeks. Rectal faeces samples were collected six times from these pigs and twice from their mothers (seven sows). Campylobacter was cultured from these samples on Preston medium. In some pigs, samples p

  4. Ammonia emissions from cattle urine and dung excreted on pasture

    DEFF Research Database (Denmark)

    Laubach, J; Taghizadeh-Toosi, Arezoo; Gibbs, S J;

    2013-01-01

    Twelve cattle were kept for three days in a circular area of 16 m radius on short pasture and fed with freshly-cut pasture. Ammonia (NH3) emissions from the urine and dung excreted by the cattle were measured with a micrometeorological mass-balance method, during the cattle presence and for 10 su...

  5. Modelling of nitrogen flow and excretion in dairy cows.

    NARCIS (Netherlands)

    Straalen, van W.M.

    1995-01-01

    In the Netherlands, the dairy husbandry is held responsible for a major part of the N-pollution of the environment. The objective of this thesis was to develop a model that predicts N flow in the animal and N excretion in faeces, urine and milk in order to reduce unnecessary N losses. The model was

  6. Urinary excretion of polyethylene glycol 3350 during colonoscopy preparation

    DEFF Research Database (Denmark)

    Rothfuss, K. S.; Bode, J.C.; Stange, E.F.;

    2006-01-01

    collected for 8 hours in 24 patients undergoing bowel cleansing with PEG 3350 for colonoscopy. The urinary excretion of PEG 3350, measured by size exclusion chromatography, ranged between 0.01 and 0.51 % of the ingested amount, corresponding to 5.8 and 896 mg in absolute amounts, respectively. Mean PEG...

  7. Zooplankton as a compound mineralising and synthesizing system: Phosphorus excretion

    NARCIS (Netherlands)

    Gulati, R.D.; Martinez, C.P.; Siewertsen, K.

    1995-01-01

    Data on phosphate excretion rates of zooplankton are based on measurements using the pelagic crustacean zoo-plankton of Lake Vechten and laboratory-cultured Daphnia galeata. In case of Daphnia sp we measured the effects of feeding on P-rich algae and P-poor algae (Scenedesmus) as food on the P-excre

  8. Excretion of depleted uranium by Gulf war veterans

    International Nuclear Information System (INIS)

    During the Persian Gulf War, in 1991, approximately 100 US military personnel had potential intakes of depleted uranium (DU), including shrapnel wounds. In 1993, the US government initiated a follow-up study of 33 Gulf War veterans who had been exposed to DU, many of whom contained embedded fragments of DU shrapnel in their bodies. The veterans underwent medical evaluation, whole-body counting, and urinalysis for uranium by kinetic phosphorescence analysis (KPA). Data are available from seven individuals who exceeded the detection limit for whole-body counting and also had elevated urinary uranium. Urinary excretion rates, in μg U g-1 creatinine, were determined in 1997 and 1999. The body contents, in mg DU, were determined in 1997; it is assumed there were no significant decreases in total body content in the interim. For the 1997 data, the mean fractional excretion was (2.4 ± 2.8) x 10-5 g-1 creatinine, and for the 1999 data, the mean was (1.1 ± 0.6) x 10-5 g-1 creatinine. However, these means are not significantly different, nor is there any correlation of excretion rate with body content. Thus, human data available to date do not provide any basis for determining the effects of particle surface area, composition and solubility, and biological processes such as encapsulation, on the excretion rate. (author)

  9. Norovirus Excretion in an Aged-Care Setting▿

    OpenAIRE

    Tu, Elise T.-V.; Rowena A. Bull; Kim, Mi-Jurng; McIver, Christopher J.; Heron, Leon; Rawlinson, William D.; White, Peter A

    2008-01-01

    Norovirus genogroup II excretion during an outbreak of gastroenteritis was investigated in an aged-care facility. Viral shedding peaked in the acute stage of illness and continued for an average of 28.7 days. The viral decay rate was 0.76 per day, which corresponds to a viral half-life of 2.5 days.

  10. Felinine excretion in domestic cat breeds: a preliminary investigation

    NARCIS (Netherlands)

    Hagen-Plantinga, E.A.; Bosch, G.; Hendriks, W.H.

    2014-01-01

    The aim of this study was to determine possible differences in felinine excretion between domesticated cat breeds. For this purpose, urine was collected from a total of 83 privately owned entire male cats from eight different breeds in the Netherlands during the period of November 2010 till November

  11. Felinine excretion in domestic cat breeds: a preliminary investigation.

    NARCIS (Netherlands)

    Hagen - Plantinga, Esther; Hendriks, Wouter; Bosch, Guido

    2014-01-01

    The aim of this study was to determine possible differences in felinine excretion between domesticated cat breeds. For this purpose, urine was collected from a total of 83 privately owned entire male cats from eight different breeds in the Netherlands during the period of November 2010 till November

  12. Molecular regulation of copper excretion in the liver

    NARCIS (Netherlands)

    Wijmenga, C; Klomp, LWJ

    2004-01-01

    Cu is an essential nutrient that is required for a broad range of cellular and molecular processes. Mammals have efficient systems to control Cu homeostasis that operate at the level of controlling uptake, distribution, sequestration and excretion of Cu. The study of diseases associated with disturb

  13. Investigations on the mechanical behavior of nanowires with twin boundaries by atomistic simulations

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Xia, E-mail: tianxia@lsec.cc.ac.cn [College of Mechanics and Materials, HoHai University, Nanjing 210098 (China)

    2015-03-10

    Atomistic simulations are used to study the deformation behavior of twinned Cu nanowires with a <111> growth orientation under tension. Due to the existence of the twin boundaries, the strength of the twinned nanowires is higher than that of the twin-free nanowire and the yielding stress of twinned nanowires is inversely proportional to the spacings of the twin boundaries. Moreover, The ductility of the twin-free nanowire is the highest of all and it grows with the increasing spacings of the twin boundaries for twinned nanowires. Besides, we find that the twin boundaries can be served as dislocation sources as well as the free surfaces and grain boundaries.

  14. Effect of Cervical Length Recovery after Laser Surgery for Twin-Twin Transfusion Syndrome

    OpenAIRE

    Finneran, Matthew; Temming, Lorene; Templin, Megan; Stephenson, Courtney

    2016-01-01

    Objective To evaluate the impact of polyhydramnios on preoperative cervical length and whether cervical length recovery after amnioreduction during selective fetoscopic laser photocoagulation (SFLP) is associated with a greater gestational age at delivery in pregnancies complicated by twin-twin transfusion syndrome (TTTS). Methods Retrospective study of 50 pregnancies complicated by TTTS treated with SFLP between March 2010 and July 2014 at a single center. Preoperative maximum vertical pocke...

  15. Twinning anisotropy of tantalum during nanoindentation

    Energy Technology Data Exchange (ETDEWEB)

    Goel, Saurav, E-mail: S.GOEL@qub.ac.uk [School of Mechanical and Aerospace Engineering, Queen' s University, Belfast, BT9 5AH (United Kingdom); Beake, Ben [Micro Materials Limited, Willow House, Yale Business Village, Ellice Way, Wrexham LL13 7YL (United Kingdom); Dalton Research Institute, Manchester Metropolitan University, Manchester, M15GD (United Kingdom); Chan, Chi-Wai [School of Mechanical and Aerospace Engineering, Queen' s University, Belfast, BT9 5AH (United Kingdom); Haque Faisal, Nadimul [School of Engineering, Robert Gordon University, Garthdee Road, Aberdeen AB10 7GJ (United Kingdom); Dunne, Nicholas [School of Mechanical and Aerospace Engineering, Queen' s University, Belfast, BT9 5AH (United Kingdom)

    2015-03-11

    Unlike other BCC metals, the plastic deformation of nanocrystalline Tantalum (Ta) during compression is regulated by deformation twinning. Whether or not this twinning exhibits anisotropy was investigated through simulation of displacement-controlled nanoindentation test using molecular dynamics (MD) simulation. MD data was found to correlate well with the experimental data in terms of surface topography and hardness measurements. The mechanism of the transport of material was identified due to the formation and motion of prismatic dislocations loops (edge dislocations) belonging to the 1/2〈111〉 type and 〈100〉 type Burgers vector family. Further analysis of crystal defects using a fully automated dislocation extraction algorithm (DXA) illuminated formation and migration of twin boundaries on the (110) and (111) orientation but not on the (010) orientation and most importantly after retraction all the dislocations disappeared on the (110) orientation suggesting twinning to dominate dislocation nucleation in driving plasticity in tantalum. A significant finding was that the maximum shear stress (critical Tresca stress) in the deformation zone exceeded the theoretical shear strength of Ta (Shear modulus/2π~10.03 GPa) on the (010) orientation but was lower than it on the (110) and the (111) orientations. In light of this, the conventional lore of assuming the maximum shear stress being 0.465 times the mean contact pressure was found to break down at atomic scale.

  16. Twin troubles--rickets causing myelofibrosis.

    Science.gov (United States)

    Kamien, Benjamin; Harris, Linda

    2007-01-01

    Myelofibrosis is an uncommon condition that causes anaemia, failure to thrive and massive splenomegaly. This case report describes migrant Sudanese twins who developed myelofibrosis secondary to severe rickets from a combination of poor diet, inadequate sun exposure, and a breastfeeding mother who wore hijab and was also vitamin D deficient. PMID:17635691

  17. Gravity Helped Terrorists Destory Twin Towers

    Institute of Scientific and Technical Information of China (English)

    李兆增

    2002-01-01

    Though terrorists triggered (触发) the collapse (倒塌) of the World Trade Center's Twin Towers, much of the energy--calculated by a physicist to have been at least 2 percent that of the atomic bomb dropped on Hiroshima(广岛)--was supplied by nature's most ubiquitous(普通存在的)force: gravity.

  18. Twin Supergravities from Yang-Mills Squared

    CERN Document Server

    Anastasiou, A; Duff, M J; Hughes, M J; Marrani, A; Nagy, S; Zoccali, M

    2016-01-01

    We consider `twin supergravities' - pairs of supergravities with $\\mathcal{N}_+$ and $\\mathcal{N}_-$ supersymmetries, $\\mathcal{N}_+>\\mathcal{N}_-$, with identical bosonic sectors - in the context of tensoring super Yang-Mills multiplets. It is demonstrated that the pairs of twin supergravity theories are related through their left and right super Yang-Mills factors. This procedure generates new theories from old. In particular, the matter coupled $\\mathcal{N}_-$ twins in $D=3,5,6$ and the $\\mathcal{N}_-=1$ twins in $D=4$ have not, as far as we are aware, been obtained previously using the double-copy construction, adding to the growing list of double-copy constructible theories. The use of fundamental matter multiplets in the double-copy construction leads us to introduce a bi-fundamental scalar that couples to the well-known bi-adjoint scalar field. It is also shown that certain matter coupled supergravities admit more than one factorisation into left and right super Yang-Mills-matter theories.

  19. Prenatal Sonographic Diagnosis of Acardiac Twins

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Ah; Song, Mi Jin [Cheil General Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2006-09-15

    This study was performed to present the prenatal sonographic findings and the associated abnormalities of acardiac twins. Seven cases of acardiac twins were reviewed retrospectively. Prenatal ultrasonography was performed in all patients at a gestational age between 12 and 27 weeks (mean 17.6 weeks). Autopsy was performed in four cases. The sonographic and autopsy findings were reviewed to report the associated abnormalities of the acardiac and donor fetuses. The diagnosis of acardiac twins was made on the basis of ultrasonography (n=6) or autopsy (n=1). The associated abnormalities of the acardiac fetuses were single umbilical artery (SUA) (n=5), abdominal wall defect (n=4), club feet (n=4), scoliosis (n=1), cleft lip and palate (n=1), digital anomaly (n=1), and umbilical cord cyst (n=1). In four of the donor fetuses, sonographic abnormalities were found. Autopsy was performed in three of the four cases to reveal hydropic change (n=2), diaphragmatic hernia (n=1) and multiple structural abnormalities of interventricular septal defect, polydactyly, club feet and SUA (n=1). Intrauterine fetal death occurred in five donors and follow-up was lost in the remaining two. Meticulous sonography enables the diagnosis of acardiac twins at an early gestational age and can reveal the associated abnormalities of the donor fetus as well as the acardiac fetus

  20. Flexible Twin Open Ring Metro WDM Network

    Institute of Scientific and Technical Information of China (English)

    Susumu Kinoshita; Cechan Tian; Satoru Ohdate; Koji Takeguchi; Yasuhiko Aoki

    2003-01-01

    We have demonstrated a flexible twin open ring WDM network for metro applications. A pair of optical switches in the network keeps the fiber rings open to prevent signal circulation. Traffics are broadcast to every node and selected at the receiving side. Superior transmission and protection switching are proved.

  1. Prenatal diagnosis of chorionicity in twins.

    LENUS (Irish Health Repository)

    Hassan, T

    2012-02-01

    The aim of this audit was to assess the accuracy of transabdominal ultrasound scan in predicting chorionicity in twin pregnancies in our unit. The presence or absence of lambda sign, T-sign, dividing membrane thickness and number of placentae were used to determine chorionicity. We retrospectively analysed these antenatal markers in 268 sets of twins delivered over a 5 year period and compared it with the postpartum placental histology and neonatal gender. Of 268 twin deliveries, 204 (76%) had both chorionicity and placental histology to compare. 67 of 84 (80%) were correctly diagnosed antenatally as monochorionic and 137 of 151 (91%) as dichorionic. In 31 cases (15%) the ultrasound diagnosis of chorionicity didn\\'t match placental histology. Seventeen were thought to be monochorionic antenatally but were confirmed dichorionic on placental histology. Overall chorionicity was correctly diagnosed in 171\\/204 (84%) using transabdominal ultrasound scan (USS) in all trimesters. However the sensitivity and specificity of USS was much higher for dichorionic twins when carried out before 14 weeks of gestation.

  2. Puerperal endometritis after abdominal twin delivery.

    Science.gov (United States)

    Suonio, S; Huttunen, M

    1994-04-01

    The infectious complications of 122 consecutive abdominal twin deliveries over the period 1984-1989 were analyzed in a prospective clinical study, comparing them with 761 singleton abdominal deliveries over the period 1984-1986. The incidence of endometritis was nearly three-fold after twin deliveries and the incidence of abdominal wound infections nearly two-fold compared with singleton abdominal pregnancies (13.1/4.7% and 5.6/3.0%). The risk of amnionitis was increased ten-fold, 6 hours after rupture of the membranes in abdominal twin delivery, but no connection was found between amnionitis and endometritis, as in singleton abdominal deliveries. Multiple regression analysis indicated only two risk factors as regards puerperal endometritis after abdominal twin delivery: age under 25 years (odds ratio 6.9, 95% confidence limits 1.9-24.8), an association also seen in singleton abdominal deliveries, and a period of more than 6 hours from rupture of membranes to delivery (odds ratio 7.8, 95% confidence limits 2.1-28.5). Multiple pregnancy appears to be associated with an increased risk of endometritis. The etiological factors remain unknown, but a large placental bed and/or immunological factors may be implicated. PMID:8160537

  3. TWINNING MECHANISMS IN LASER PROCESSED CERAMIC COATINGS

    NARCIS (Netherlands)

    de Hosson, J.T.M.

    1995-01-01

    Twinning behaviour and martensitic transformations are observed in laser treated (Fe, Cr) spinel with chemical formula FexCr3-xO4 (0

  4. Effect of diethyl ether on the biliary excretion of acetaminophen.

    Science.gov (United States)

    Watkins, J B; Siegers, C P; Klaassen, C D

    1984-10-01

    The biliary and renal excretion of acetaminophen and its metabolites over 8 hr was determined in rats exposed to diethyl ether by inhalation for 1 hr. Additional rats were anesthetized with urethane (1 g/kg ip) while control animals were conscious throughout the experiment (surgery was performed under hexobarbital narcosis: 150 mg/kg ip; 30-min duration). The concentration of UDP-glucuronic acid was decreased 80% in livers from ether-anesthetized rats but was not reduced in urethane-treated animals when compared to that in control rats. The concentration of reduced glutathione was not affected by either urethane or diethyl ether. Basal bile flow was not altered by the anesthetic agents. Bile flow rate after acetaminophen injection (100 mg/kg iv) was increased slightly over basal levels for 2 hr in hexobarbital-treated control rats, was unaltered in urethane-anesthetized animals, and was decreased throughout the 8-hr experiment in rats exposed to diethyl ether for 1 hr. In control and urethane-anesthetized animals, approximately 30-35% of the total acetaminophen dose (100 mg/kg iv) was excreted into bile in 8 hr, while only 16% was excreted in rats anesthetized with diethyl ether. Urinary elimination (60-70% of the dose) was not altered by exposure to ether. Separation of metabolites by reverse-phase high-pressure liquid chromatography showed that ether decreased the biliary elimination of unchanged acetaminophen and its glucuronide, sulfate, and glutathione conjugates by 47, 40, 49, and 73%, respectively, as compared to control rats. Excretion of unchanged acetaminophen and the glutathione conjugate into bile was depressed in urethane-anesthetized animals by 45 and 66%, respectively, whereas elimination of the glucuronide and sulfate conjugates was increased by 27 and 50%, respectively. These results indicate that biliary excretion is influenced by the anesthetic agent and that diethyl ether depresses conjugation with sulfate and glutathione as well as glucuronic

  5. Establishing a Twin Registry in Guinea-Bissau

    DEFF Research Database (Denmark)

    Bjerregaard-Andersen, Morten; Gomes, Margarida A; Joaquím, Luis C;

    2013-01-01

    , diabetes mellitus, metabolic syndrome, and infectious diseases such as HIV, tuberculosis, and malaria. A major focus area is also the etiology of low birth weight and how epigenetic processes might modulate the consequences of low birth weight in Sub-Saharan Africa. For this, monozygotic twin studies...... represent a powerful tool. Though twin studies have been carried out by the Bandim Health Project for more than 30 years, the renewed registry described here was officially established in 2009 and includes both a cohort of newborn twins and a cohort of young and adult twins. Currently more than 1,500 twins...

  6. Prospective risk of fetal death in uncomplicated monochorionic twins.

    LENUS (Irish Health Repository)

    Farah, Nadine

    2012-03-01

    A retrospective cohort study was carried out in a university teaching hospital to determine the prospective risk of unexpected fetal death in uncomplicated monochorionic diamniotic (MCDA) twin pregnancies after viability. All MCDA twins delivered at or after 24 weeks\\' gestation from July 1999 to July 2007 were included. Pregnancies with twin-twin transfusion syndrome, growth restriction, structural abnormalities, or twin reversed arterial perfusion sequence were excluded. Of the 144 MCDA twin pregnancies included in our analysis, the risk of intrauterine death was 4.9%. The prospective risk of unexpected intrauterine death was 1 in 43 after 32 weeks\\' gestation and 1 in 37 after 34 weeks\\' gestation. Our results demonstrate that despite close surveillance, the unexpected intrauterine death rate in uncomplicated MCDA twin pregnancies is high. This rate seems to increase after 34 weeks\\' gestation, suggesting that a policy of elective preterm delivery warrants evaluation.

  7. Heritability of eleven metabolic phenotypes in Danish and Chinese twins

    DEFF Research Database (Denmark)

    Li, Shuxia; Duan, Hongmei; Pang, Zengchang;

    2013-01-01

    A twin-based comparative study on the genetic influences in metabolic endophenotypes in two populations of substantial ethnic, environmental, and cultural differences was performed. Design and Methods: Data on 11 metabolic phenotypes including anthropometric measures, blood glucose, and lipids...... levels as well as blood pressure were available from 756 pairs of Danish twins (309 monozygotic and 447 dizygotic twin pairs) with a mean age of 38 years (range: 18-67) and from 325 pairs of Chinese twins (183 monozygotic and 142 dizygotic twin pairs) with a mean age of 40.5 years (range: 18-69). Twin...... was more genetically controlled in Danish than in Chinese twins. Conclusions: Metabolic endophenotypes show disparity in their genetic determinants in populations under distinct environmental conditions....

  8. Albumin contributes to kidney disease progression in Alport syndrome.

    Science.gov (United States)

    Jarad, George; Knutsen, Russell H; Mecham, Robert P; Miner, Jeffrey H

    2016-07-01

    Alport syndrome is a familial kidney disease caused by defects in the collagen type IV network of the glomerular basement membrane. Lack of collagen-α3α4α5(IV) changes the glomerular basement membrane morphologically and functionally, rendering it leaky to albumin and other plasma proteins. Filtered albumin has been suggested to be a cause of the glomerular and tubular injuries observed at advanced stages of Alport syndrome. To directly investigate the role that albumin plays in the progression of disease in Alport syndrome, we generated albumin knockout (Alb(-/-)) mice to use as a tool for removing albuminuria as a component of kidney disease. Mice lacking albumin were healthy and indistinguishable from control littermates, although they developed hypertriglyceridemia. Dyslipidemia was observed in Alb(+/-) mice, which displayed half the normal plasma albumin concentration. Alb mutant mice were bred to collagen-α3(IV) knockout (Col4a3(-/-)) mice, which are a model for human Alport syndrome. Lack of circulating and filtered albumin in Col4a3(-/-);Alb(-/-) mice resulted in dramatically improved kidney disease outcomes, as these mice lived 64% longer than did Col4a3(-/-);Alb(+/+) and Col4a3(-/-);Alb(+/-) mice, despite similar blood pressures and serum triglyceride levels. Further investigations showed that the absence of albumin correlated with reduced transforming growth factor-β1 signaling as well as reduced tubulointerstitial, glomerular, and podocyte pathology. We conclude that filtered albumin is injurious to kidney cells in Alport syndrome and perhaps in other proteinuric kidney diseases, including diabetic nephropathy. PMID:27147675

  9. The effect of chorionicity and twin-to-twin delivery time interval on short-term outcome of the second twin

    DEFF Research Database (Denmark)

    Hjortø, Sofie; Nickelsen, Carsten; Petersen, Janne;

    2013-01-01

    found no difference in the decrease of pH (p = 0.912) and Apgar (p = 0.609) in relation to increasing time interval. Neonatal unit (NICU) admissions did not differ (p = 0.167). Apgar ≤ 7 (p Apgar...... ≤ 7 and second twin pH ≤ 7.00 (p = 0.003) increased second twin risk of NICU admission. Conclusions: Increasing delivery interval was associated with a significant decrease in pH and Apgar, but there was no difference between MC and DC twins. Low Apgar of the first twin increased the risk of second...

  10. Serum albumin concentrations and oedema in the newborn

    OpenAIRE

    1986-01-01

    Serum albumin concentration was measured in 195 infants of 25 to 42 weeks' gestation during the neonatal period. Concentrations were significantly lower in preterm infants, rising from a mean of 19 g/l at 26 weeks to 31 g/l at term. There was a 15% increase in albumin concentrations in the first three weeks of life. Oedema in the early and late neonatal period was common in preterm infants but correlated poorly with hypoalbuminaemia. Measurement of serum albumin concentrations in preterm infa...

  11. Establishment of an Enzyme Linked Immunosorbent Assay for Albumin

    International Nuclear Information System (INIS)

    A sensitive and specific ELISA for Albumin was established by using Albumin antibody coated on the microtiter plate, Albumin labeled horseradish peroxidase(HRP). The sensitivity of the assay was 0.28 mg/L. The intra-and inter-assay CVs were 2.63%-5.28% and 2.40%-4.26% respectively. The analytical recovery was 95.0%-106.4%, the coefficient correlation was 0.9974. This method for measuring Alb was rapid, sensitive and convenient. It is suitable for clinical detection and research application. (authors)

  12. Cyclosporin A Inhibits Albumin Synthesis in Huh7 Cells

    OpenAIRE

    Jeon, Youn Joo; Kim, Yong Soo

    2011-01-01

    Background/Aims Hypoalbuminemia occurs frequently in renal transplant recipients immediately after renal transplantation. We studied the regulation of hepatic albumin synthesis by cyclosporin A (CsA) in Huh7 cells. Methods Huh7 cells were incubated with various concentrations of CsA for 4, 8, 16, and 24 hours. Albumin was measured in Huh7 cell-conditioned medium by sandwich enzyme-linked immunosorbent assay and Western blot. Albumin mRNA expression was analyzed by Northern blotting in CsA-tre...

  13. Atomic structure and chemistry of human serum albumin

    Science.gov (United States)

    He, Xiao M.; Carter, Daniel C.

    1992-01-01

    The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and ILIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.

  14. The effect of surgery on the renal excretion of beta 2-microglobulin.

    Science.gov (United States)

    Walenkamp, G H; Vree, T B; Guelen, P J; Jongman-Nix, B

    1983-03-28

    Surgical trauma causes an increase in the renal excretion rate of beta 2-microglobulin whilst creatinine excretion is not influenced. The increase in the renal excretion rate of beta 2-microglobulin is probably the result of an increased release of beta 2-microglobulin by the cells which exceeds a maximum in the active tubular reabsorption of the compound by the proximal tubule cell. The renal excretion of beta 2-microglobulin is proportional to the relative clinical trauma score. PMID:6189646

  15. Excretion of Four Catechins in Tea Polyphenols in Rats

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Objective To investigate excretion profiles of the four major anti-oxidant active catechins, (-) epigallo-catechin-3-gallate (EGCG), (-) epicatechin-3-gallate (ECG), (-) epigallocatechin (EGC), and epicatechin (EC) in tea polyphenols (TP) in rats in order to provide experimental data for clinical uses and development of TP as a novel drug. Methods The above four catechins in urine, bile, and feces were simultaneously determined by high performance liquid chromatography coupled with ultraviolet absorption detector (HPLC-UV) assay with a binary gradient elution. The samples were extracted by ethyl acetate prior to HPLC. The quantification was carried out by peak area internal standard method. Following iv dosing TP 100 mg/kg to rats, the samples were collected at different time intervals up to 8 h (urine and bile) and 24 h (feces). Results The urinary Ae, 0-8 h (cumulative excretion amount over 8 h) of EGCG, ECG, EGC, and EC were, on the average, 150.83, 30.75, 116.69, and 254.56 μg, corresponding to fe, 0-8 h (cumulative excretion fraction of dose over 8 h) of 1.45%, 0.84%, 7.88%, and 10.73%, respectively; the biliary Ae, 0-8 h were 12.61, 42.64, 6.61, and 1.24 μg, corresponding to the fe, 0-8 h of 0.12%, 1.16%, 0.45%, and 0.053%,respectively. For fecal excretion, only EGCG and EGC were detected with Ae, 0-24 h of 7.38 μg (fe, 0-24 h of 0.07%) and 157 μg (fe, 0-24 h of 9.99 %), respectively. The fe, total (the total fe of 3 excretory routes) were 18.32%, 10.78%, 2.00%, and 1.64% for EGC, EC, ECG, and EGCG, respectively. Conclusion EGCG and EC are mainly excreted in urine, ECG in bile, and EGC in feces by reference to their Ae and fe. The excretion of the four catechins based on fe, total is ranked in order of EGC > EC > ECG > EGCG. Only small amount of four catechins are recovered in urine, bile, and feces, indicating an extensive metabolic conversion of catechins in the rat body.

  16. Personality and birth order in monozygotic twins adopted apart: a test of Sulloway's theory; Research Reviews: twin births and cancer risk in mothers, male sexual dysfunction, twin study of ultimatum game behavior; Human Interest: 'The Land of Twins', twin-like reunion-I, twin-like reunion-II.

    Science.gov (United States)

    Segal, Nancy L

    2008-02-01

    A brief overview of Sulloway's (1996) theory of birth order and personality is presented. A reared apart twin approach for testing his personality findings regarding openness to experience and conscientiousness in first borns and later borns is described. This is followed by summaries of three recent twin studies. The topics include cancer risk in mother of twins, sexual dysfunction in males and responder behavior during ultimatum games. This article concludes with a discussion of twinning rates and rituals among the Yoruba of western Nigeria, and descriptions of two unusual reunions between siblings and twins.

  17. Dauphiné twins or not, that's the question

    Science.gov (United States)

    Sintubin, Manuel; Wenk, Hans-Rudolf

    2014-05-01

    Dauphiné twinning in trigonal low-quartz is defined by a two-fold axis (180° rotation) about the crystallographic c-axis [0001]. Dauphiné twinning has thus no effect on the orientation of the crystallographic axes of quartz, but transposes the positive and negative rhombs. Therefore, Dauphiné twinning remain undetectable by standard optical microscopy. Dauphiné twins were first resolved in euhedral quartz crystals by natural or artificial etching. In texture analysis, the different orientation distribution of the positive and negative rhombs indicates that Dauphiné twinning has likely been active within many polycrystalline quartz aggregates. Since the introduction of EBSD-OIM (SEM) Dauphiné twin boundaries can effectively be mapped in polycrystalline quartz aggregates. Dauphiné twins in quartz can be a primary microstructure, formed during crystal growth, or a secondary microstructure, resulting from transformational or mechanical twinning. Transformational Dauphiné twinning, occurring at the polymorphic transition of hexagonal high-quartz to trigonal low-quartz (573°C at atmospheric conditions), causes a variant selection through slight atomic displacements arising from internal thermal vibrations. Mechanical Dauphiné twinning in low-quartz, on the other hand, is stress-induced. It acts to align the direction of greatest elastic compliance, orthogonal to the positive rhombs, with the compressive principal stress direction. Dauphiné twin boundaries separate the two variant domains within the quartz grain. The question, though, is which of the variant domains is the 'twin' and which is the 'host'. In previous work on mechanical Dauphiné twinning in naturally deformed quartz-bearing rocks, the distinction between 'host' and 'twin' has been made mostly arbitrarily, guided by an observations bias (e.g. smallest fraction in grain represents the 'twin') or an interpretational bias (e.g. twins develop at grain boundaries). However, with respect to grains

  18. KADAR ALBUMIN SERUM DAN FAAL GINJAL ANAK

    Directory of Open Access Journals (Sweden)

    Lydia Kosnadi

    2012-09-01

    Full Text Available Serum albumin concentration (Sa is one of the determinants of single nephron glomerular filtration rate. Hypoalbuminemia is frequently encountered in our country due to protein calory malnutrition, liver function disorders and others. The renal function or glomerular filtration rate (GFR measurement in children suffering from renal diseases would be able to provide information regarding the extent of the renal damage. The aim of this study was to know the interaction between Sa and GFR in children. GFR was measured by standard inulin clearance (Cin and conventional endogenous creatinine clearance (Ccr in 112 children hospitalized with renal diseases. Standard renal function status test, namely IKA-1984 was utilized for the renal function measurement. Result of this study showed a positive correlation between : Sa, Cin and Ccr in pediatric patients with decreased renal function : Cin = 5,23 + 12,14 Sa (r = 0,50; p = 0,007; n = 26 and Cr = 7,10 + 14,47 Sa (r = 0,53; p = 0,005; n = 26, so that the lower Sa level, usually will indicate the lower renal function and the more severe the renal failure.

  19. Uric acid excretion predicts increased aggression in urban adolescents.

    Science.gov (United States)

    Mrug, Sylvie; Mrug, Michal

    2016-09-01

    Elevated levels of uric acid have been linked with impulsive and disinhibited behavior in clinical and community populations of adults, but no studies have examined uric acid in relation to adolescent aggression. This study examined the prospective role of uric acid in aggressive behavior among urban, low income adolescents, and whether this relationship varies by gender. A total of 84 adolescents (M age 13.36years; 50% male; 95% African American) self-reported on their physical aggression at baseline and 1.5years later. At baseline, the youth also completed a 12-h (overnight) urine collection at home which was used to measure uric acid excretion. After adjusting for baseline aggression and age, greater uric acid excretion predicted more frequent aggressive behavior at follow up, with no significant gender differences. The results suggest that lowering uric acid levels may help reduce youth aggression. PMID:27180134

  20. Proteomic analysis of Taenia solium metacestode excretion-secretion proteins.

    Science.gov (United States)

    Victor, Bjorn; Kanobana, Kirezi; Gabriël, Sarah; Polman, Katja; Deckers, Nynke; Dorny, Pierre; Deelder, André M; Palmblad, Magnus

    2012-06-01

    The metacestode larval stage of Taenia solium is the causal agent of a zoonotic disease called cysticercosis. The disease has an important impact on pork trade (due to porcine cysticercosis) and public health (due to human neurocysticercosis). In order to improve the current diagnostic tools and to get a better understanding of the interaction between T. solium metacestodes and their host, there is a need for more information about the proteins that are released by the parasite. In this study, we used protein sequences from different helminths, 1DE, reversed-phase LC, and MS/MS to analyze the excretion-secretion proteins produced by T. solium metacestodes from infected pigs. This is the first report of the T. solium metacestode excretion-secretion proteome. We report 76 proteins including 27 already described T. solium proteins, 17 host proteins and 32 proteins likely to be of T. solium origin, but identified using sequences from other helminths.

  1. Relation of urinary calcium and magnesium excretion to blood pressure

    DEFF Research Database (Denmark)

    Kesteloot, Hugo; Tzoulaki, Ioanna; Brown, Ian J;

    2011-01-01

    of calcium and magnesium in 2 cross-sectional studies. The International Study of Macro- and Micro-Nutrients and Blood Pressure (INTERMAP) comprised 4,679 persons aged 40-59 years from 17 population samples in China, Japan, the United Kingdom, and the United States, and the International Cooperative Study...... on Salt, Other Factors, and Blood Pressure (INTERSALT) comprised 10,067 persons aged 20-59 years from 52 samples around the world. Timed 24-hour urine collections, BP measurements, and nutrient data from four 24-hour dietary recalls (INTERMAP) were collected. In multiple linear regression analyses......) of higher urinary calcium excretion (associations were smaller for diastolic BP) in INTERMAP. Qualitatively similar associations were observed in INTERSALT analyses. Associations between magnesium excretion and BP were small and nonsignificant for most of the models examined. The present data suggest...

  2. Development of FET-type albumin sensor for diagnosing nephritis.

    Science.gov (United States)

    Park, Keun-Yong; Sohn, Young-Soo; Kim, Chang-Kyu; Kim, Hong-Seok; Bae, Young-Seuk; Choi, Sie-Young

    2008-07-15

    An albumin biosensor based on a potentiometric measurement using Biofield-effect-transistor (BioFET) has been designed and fabricated, and its characteristics were investigated. The BioFET was fabricated using semiconductor integrated circuit (IC) technology. The gate surface of the BioFET was chemically modified by newly developed self-assembled monolayer (SAM) synthesized by a thiazole benzo crown ether ethylamine (TBCEA)-thioctic acid to immobilize anti-albumin. SAM formation, antibody immobilization, and antigen-antibody interaction were verified using surface plasmon resonance (SPR). The output voltage changes of the BioFET with respect to various albumin concentrations were obtained. Quasi-reference electrode (QRE) and reference FET (ReFET) has been integrated with the BioFET, and its output characteristic was investigated. The results demonstrate the feasibility of the BioFET as the albumin sensor for diagnosing nephritis.

  3. Development of FET-type albumin sensor for diagnosing nephritis.

    Science.gov (United States)

    Park, Keun-Yong; Sohn, Young-Soo; Kim, Chang-Kyu; Kim, Hong-Seok; Bae, Young-Seuk; Choi, Sie-Young

    2008-07-15

    An albumin biosensor based on a potentiometric measurement using Biofield-effect-transistor (BioFET) has been designed and fabricated, and its characteristics were investigated. The BioFET was fabricated using semiconductor integrated circuit (IC) technology. The gate surface of the BioFET was chemically modified by newly developed self-assembled monolayer (SAM) synthesized by a thiazole benzo crown ether ethylamine (TBCEA)-thioctic acid to immobilize anti-albumin. SAM formation, antibody immobilization, and antigen-antibody interaction were verified using surface plasmon resonance (SPR). The output voltage changes of the BioFET with respect to various albumin concentrations were obtained. Quasi-reference electrode (QRE) and reference FET (ReFET) has been integrated with the BioFET, and its output characteristic was investigated. The results demonstrate the feasibility of the BioFET as the albumin sensor for diagnosing nephritis. PMID:18440216

  4. A twin study of computer anxiety in Turkish adolescents.

    Science.gov (United States)

    Deryakulu, Deniz; Calışkan, Erkan

    2012-04-01

    The present study investigated computer anxiety within a sample of Turkish twins aged 10-18. A total of 185 twin-pairs participated in the study. Of the twins, 64 pairs (34.6 percent) were monozygotic (MZ) and 121 pairs (65.4 percent) were dizygotic (DZ). Of the 121 DZ twins, 54 pairs (44.63 percent) were same-sex twins and 67 pairs (55.37 percent) were opposite-sex twins. Computer anxiety was assessed using Computer Anxiety Rating Scale-Turkish Version (CARS-TV), one of the three main scales of "Measuring Technophobia Instruments" developed by Rosen and Weil. The results of paired t test comparisons showed no significant differences in MZ and same-sex DZ twin-pairs' levels of computer anxiety. On the other hand, a significant difference was found in opposite-sex DZ twin-pairs' level of computer anxiety. Interesting enough, males appeared to be more computer anxious than their female co-twins. In the present study, using Falconer's formula, heritability estimate for computer anxiety was derived from correlations based on MZ and DZ twins' mean scores on CARS-TV. The results showed that 57 percent of the variance in computer anxiety was from genetics and 41.5 percent was from nonshared environmental factors. Shared environmental influence, on the other hand, was very small and negligible. Interpretations of results and potential directions for future research are presented.

  5. Feature Discretization for Individuality Representation in Twins Handwritten Identification

    Directory of Open Access Journals (Sweden)

    Bayan O. Mohammed

    2011-01-01

    Full Text Available Problem statement: The study on twins is an important form of study in the forensic and biometrics field as twins share similar genetic traits. Handwriting is one of the common types of forensic evidence. Differentiating the similarities of writing of a pair of twins is critical in establishing the reliability of handwriting identification. Writing style can be used as biometric features in authenticating individual uniqueness where these unique features can be used to identify the writer, including between a pair of twins. Existing works in Writer Identification concentrate on feature extraction and the classification task in order to identify authorship. The high similarity in a pair of twins’ handwriting may degrade classification performance. There should be some standards to represent these unique features before entering into the classification task which is with the use of discretization technique. Approach: We proposed a new framework for writer identification in terms of identifying twins' handwriting and showed the effect of discretization process on handwriting samples of a pair of twins in order to obtain individual identification. Results: An experiment has been done at the Sulaimania University in Iraq with fourteen pairs of identical twins where each twin provides 4 samples of handwriting for the purpose of data collecting. These samples were implemented in this research making a comparison between the new proposed framework and classic framework. Conclusion: Our experimental results showed that with new framework identification of handwriting of a pair of twins can be improved through the discretization process.

  6. A twin study of computer anxiety in Turkish adolescents.

    Science.gov (United States)

    Deryakulu, Deniz; Calışkan, Erkan

    2012-04-01

    The present study investigated computer anxiety within a sample of Turkish twins aged 10-18. A total of 185 twin-pairs participated in the study. Of the twins, 64 pairs (34.6 percent) were monozygotic (MZ) and 121 pairs (65.4 percent) were dizygotic (DZ). Of the 121 DZ twins, 54 pairs (44.63 percent) were same-sex twins and 67 pairs (55.37 percent) were opposite-sex twins. Computer anxiety was assessed using Computer Anxiety Rating Scale-Turkish Version (CARS-TV), one of the three main scales of "Measuring Technophobia Instruments" developed by Rosen and Weil. The results of paired t test comparisons showed no significant differences in MZ and same-sex DZ twin-pairs' levels of computer anxiety. On the other hand, a significant difference was found in opposite-sex DZ twin-pairs' level of computer anxiety. Interesting enough, males appeared to be more computer anxious than their female co-twins. In the present study, using Falconer's formula, heritability estimate for computer anxiety was derived from correlations based on MZ and DZ twins' mean scores on CARS-TV. The results showed that 57 percent of the variance in computer anxiety was from genetics and 41.5 percent was from nonshared environmental factors. Shared environmental influence, on the other hand, was very small and negligible. Interpretations of results and potential directions for future research are presented. PMID:22394420

  7. Ammonia emissions from cattle urine and dung excreted on pasture

    Directory of Open Access Journals (Sweden)

    J. Laubach

    2013-01-01

    Full Text Available Twelve cattle were kept for three days in a circular area of 16 m radius on short pasture and fed with freshly-cut pasture. Ammonia (NH3 emissions from the urine and dung excreted by the cattle were measured with a micrometeorological mass-balance method, during the cattle presence and for 10 subsequent days. Daily-integrated emission rates peaked on Day 3 of the experiment (last day of cattle presence and declined steadily for five days thereafter. Urine patches were the dominant sources for these emissions. On Day 9, a secondary emissions peak occurred, with dung pats likely to be the main sources. This interpretation is based on simultaneous observations of the pH evolution in urine patches and dung pats created next to the circular plot. Feed and dung samples were analysed to estimate the amounts of nitrogen (N ingested and excreted. Total N volatilised as NH3 was 19.8 (± 0.9% of N intake and 22.4 (± 1.3% of N excreted. The bimodal shape of the emissions time series allowed to infer separate estimates for volatilisation from urine and dung, respectively, with the result that urine accounted for 88.6 (± 2.6% of the total NH3 emissions. The emissions from urine represented 25.5 (± 2.0% of the excreted urine-N, while the emissions from dung amounted to 11.6 (± 2.7% of the deposited dung-N. Emissions from dung may have continued after Day 13 but were not resolved by the measurement technique. A simple resistance model shows that the magnitude of the emissions from dung is controlled by the resistance of the dung crust.

  8. Study about excretion of 210 Po in urine

    International Nuclear Information System (INIS)

    The urine of mines's workers are analysed to detect the presence of 210 Po. The results was compared with the workers and with a control population. Cigarettes samples was analysed two and confirmed the 210 presence. The control population individuals were divided in smokers and non smokers and them urine was investigated the influence of the smoke in the 210 Po excretion. (L.M.J.)

  9. Ammonia Production, Excretion, Toxicity, and Defense in Fish: A Review

    OpenAIRE

    Yuen K Ip; Chew, Shit F.

    2010-01-01

    Many fishes are ammonotelic but some species can detoxify ammonia to glutamine or urea. Certain fish species can accumulate high levels of ammonia in the brain or defense against ammonia toxicity by enhancing the effectiveness of ammonia excretion through active NH 4 + transport, manipulation of ambient pH, or reduction in ammonia permeability through the branchial and cutaneous epithelia. Recent reports on ammonia toxicity in mammalian brain reveal the importance of permeation of ammonia thr...

  10. Excretion of radium in relation to dietary intake

    International Nuclear Information System (INIS)

    Comprehensive measurements of the Ra226 contents of more than 200 common foods and 100 of the principal supplies of drinking water in Great Britain have been used to compare the mean intakes of radium per person from these sources, in a number of occupational groups as well as among the populations of various region; of the country. In spite of the wide range of activities present in foods, the mean intakes show little variation among the groups, the values lying between 2 and 3 pc per person per day. The drinking waters in Britain have radium contents differing by factors of up to 250 to 1, but in the majority of cases the absolute levels are so low relative to those present in the staple foods that the mean intakes from water represent only 5 to 6% of the mean total amounts of radium ingested by each individual. Only in one exceptional area of the country, representing less than 1% of the total population, is it possible for the daily intakes from water to exceed those from food. Measurements of faecal excretion resulting from the normal dietary intake have shown that in the case of young adults, the average level of Ra226 excreted in this way is 2 to 2.5 pc/d. This figure agrees with the estimates of the mean daily intakes. Human metabolic studies have shown that the large majority of each day's dietary intake of radium is excreted within 24 to 48 h, but attempts to assess the fractional retention in adults have given variable results. Measurements of the daily intakes and faecal excretions of a young child, over a period of 33 d, indicate that the retention of radium during periods of active bone growth may be as high as 10% or even more. (author)

  11. Blood pressure, sodium intake, insulin resistance, and urinary nitrate excretion.

    Science.gov (United States)

    Facchini, F S; DoNascimento, C; Reaven, G M; Yip, J W; Ni, X P; Humphreys, M H

    1999-04-01

    The objective of this study was to investigate the relationships among various humoral factors thought to be involved in the regulation of blood pressure during high NaCl intake. Nineteen healthy subjects underwent sequential 5-day periods ingesting a low-sodium (25 mmol/d) or high-sodium (200 mmol/d) diet. Insulin resistance was assessed by the steady-state plasma glucose concentration at the end of a 3-hour insulin suppression test. Insulin resistance correlated inversely with natriuresis (P=0.04) and directly with increase in weight (P=0.03). The increase in mean arterial pressure associated with the high-sodium diet correlated directly with the gain in weight (P<0.05) and inversely with the increase in urinary nitrate excretion (P<0.0001). In a multiple regression model, more than 2/3 of the variance in mean arterial pressure was accounted for by the gain in weight and change in urinary nitrate excretion. The steady-state plasma glucose concentrations obtained with the 2 diets were similar, indicating that insulin resistance was unaffected by sodium intake. During high sodium intake, plasma renin activity and aldosterone decreased and plasma atrial natriuretic peptide increased; these changes did not correlate with the change in mean arterial pressure, insulin resistance, or change in urinary nitrate excretion. To the extent that urinary nitrate excretion reflects activity of the endogenous nitric oxide system, these results suggest that the salt sensitivity of mean arterial pressure may be related to blunted generation of endogenous nitric oxide. The results also demonstrate that insulin-resistant individuals have an impaired natriuretic response to high sodium intake. PMID:10205239

  12. Transport of nitrated albumin across continuous vascular endothelium

    OpenAIRE

    Predescu, Dan; Predescu, Sanda; Malik, Asrar B.

    2002-01-01

    Because modification of plasma albumin on tyrosine residues generates nitrated albumin (NOA) that may function as a mechanism of nitrogen monoxide clearance from microcirculation, we investigated biochemicaly and morphologically the cell surface binding and the transendothelial transport of NOA. An electron microscopic study was carried out with mouse lungs and hearts perfused in situ with NOA and NOA-Au complexes. The results indicate that NOA-Au can bind to the endothelial cell surface, and...

  13. Biliary excretion of iron and ferritin in idiopathic hemochromatosis

    International Nuclear Information System (INIS)

    The role of biliary excretion of iron and ferritin in iron overload was studied and evaluated. Ten patients with idiopathic hemochromatosis and two groups of controls (14 gallstone patients and 16 healthy subjects) were included. Liver tissue (obtained by percutaneous or operative biopsy) was investigated with light microscopy and transmission electron microscopy in combination with x-ray microanalysis. Fasting bile samples were obtained through duodenal aspiration or at cholecystectomy. Iron was determined in liver tissue and bile using atomic absorption spectroscopy, and ferritin was determined in serum and bile with a radioimmunoassay technique. All patients with hemochromatosis had iron-positive staining as seen in light microscopy. Electron microscopy showed iron-containing proteins in the lysosomes and cytosol of liver parenchymal cells, and this observation was supported by x-ray microanalysis. Hepatic iron concentration was increased about eightfold in the patients with hemochromatosis (p less than 0.001). Biliary iron concentration, expressed per millimole of bile acid, was increased about twofold (p less than 0.05) and biliary ferritin concentration about fivefold (p less than 0.001) in hemochromatosis. Four of the patients with hemochromatosis were reexamined after completed treatment with venesection; this resulted in normalized biliary concentrations of iron and ferritin. We conclude that biliary secretion of ferritin occurs in humans and that both iron and ferritin excretion are enhanced in hepatic iron overload. The apparently limited capacity of biliary iron excretion may be of importance for the hepatic iron accumulation in hemochromatosis

  14. Biliary excretion of iron and ferritin in idiopathic hemochromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Hultcrantz, R.; Angelin, B.; Bjoern-Rasmussen, E.E.; Ewerth, S.; Einarsson, K.

    1989-06-01

    The role of biliary excretion of iron and ferritin in iron overload was studied and evaluated. Ten patients with idiopathic hemochromatosis and two groups of controls (14 gallstone patients and 16 healthy subjects) were included. Liver tissue (obtained by percutaneous or operative biopsy) was investigated with light microscopy and transmission electron microscopy in combination with x-ray microanalysis. Fasting bile samples were obtained through duodenal aspiration or at cholecystectomy. Iron was determined in liver tissue and bile using atomic absorption spectroscopy, and ferritin was determined in serum and bile with a radioimmunoassay technique. All patients with hemochromatosis had iron-positive staining as seen in light microscopy. Electron microscopy showed iron-containing proteins in the lysosomes and cytosol of liver parenchymal cells, and this observation was supported by x-ray microanalysis. Hepatic iron concentration was increased about eightfold in the patients with hemochromatosis (p less than 0.001). Biliary iron concentration, expressed per millimole of bile acid, was increased about twofold (p less than 0.05) and biliary ferritin concentration about fivefold (p less than 0.001) in hemochromatosis. Four of the patients with hemochromatosis were reexamined after completed treatment with venesection; this resulted in normalized biliary concentrations of iron and ferritin. We conclude that biliary secretion of ferritin occurs in humans and that both iron and ferritin excretion are enhanced in hepatic iron overload. The apparently limited capacity of biliary iron excretion may be of importance for the hepatic iron accumulation in hemochromatosis.

  15. Uptake, retention and excretion of strontium in man

    International Nuclear Information System (INIS)

    The absorption of strontium from the gastrointestinal tract is discussed in relation to the diet and the different components of a bread-milk diet. A brief review is given of the results obtained by using chelators and diets high in calcium in order to decrease the strontium absorption. The ratios of strontium to calcium in the different body compartments for adult man is discussed. The results of recent experimental work on normal man on a constant diet, are reviewed with particular reference to the urinary excretion and the retention of Sr85 contained in the experimental diet. The endogenous faecal excretion is also derived. These results are compared with those obtained from a single intravenous injection of radioactive strontium. For all the subjects the retention was obtained from whole-body counting using a pulse height analyser. The retention of the strontium in the skeleton is analysed and it is postulated that there are at least three degrees of binding of radioactive strontium with bone. In particular the retention several months after the dose and the relationship of this retention to the radiation dose to the skeleton from Sr90 is discussed. A formula is proposed for the evaluation of body retention of a radioactive dose of strontium from the radioactivity excreted in the urine. (author)

  16. Tissue distribution and excretion pattern of 51Cr in animals

    International Nuclear Information System (INIS)

    To study distribution and excretion pattern of chromium, 51CrCl3 was orally administered in doses of 66.6 μCi to each rat. Lungs, liver and testis accumulated relatively higher radioactivity earlier and this accumulation persisted in liver and testis for 192 hr. The lungs, heart muscles and gall bladder showed a gradual decline after initial uptake whereas in kidney and spleen it continued to increase as a function of time. Uptake of 51Cr per unit weight of the small intestine was greater than the stomach and the large intestine. On an average, 70.15 percent of the orally administered 51Cr was excreted in faeces within 192 hr of dosing. In the second experiment, six male kids weighing 23.87 kg, on an average, were given orally 500 μCi of 51Cr. Kids were maintained on concentrate mixture and green berseem which contained 0.43 ppm and 0.195 ppm chromium, respectively. The balance studies revealed that 94.93 percent of the total 51Cr dose was excreted in the faeces and 1.93 percent in the urine during 7 day period. Net absorption of 51Cr was, however, only 9.0 percent. (auth.)

  17. Evaluation of aldosterone excretion in very low birth weight infants.

    Science.gov (United States)

    Abdel Mohsen, Abdel Hakeem; Taha, Gamal; Kamel, Bothina A; Maksood, Mohamed Abdel

    2016-01-01

    Data about aldosterone production and excretion in the neonatal period are still few and controversial. Our objectives are to assess urinary aldosterone excretion (UAE) in very low birth weight (VLBW) infants and to identify clinical and biochemical variables that may influence this excretion. Thirty VLBW infants (14 males and 16 females), their gestational age value was 0.176 ± 0.05 μg/24 h and the mean absolute UAE was 1906 ± 271 pg/mL. There was a statistically significant positive correlation between UAE and gestational age and birth weight; also, infants with respiratory distress syndrome had higher urinary aldosterone levels than infants without respiratory distress. Only plasma sodium was a significant independent factor that negatively influenced UAE on linear regression analysis. The renin-angiotensin-aldosterone system of VLBW infants seems to be able, even immediately after birth, to respond to variations of plasma sodium concentrations; measurement of UAE constitutes an interesting method to determine aldosterone production in VLBW infants. PMID:27424689

  18. Coherent light in intense spatiospectral twin beams

    Science.gov (United States)

    Peřina, Jan

    2016-06-01

    Intense spatio-spectral twin beams generated in the regime with pump depletion are analyzed applying a suggested quantum model that treats the signal, idler, and pump fields in the same way. The model assumes the signal and idler fields in the form of the generalized superposition of signal and noise and reveals nonzero signal coherent components in both fields, contrary to the models developed earlier. The influence of coherent components on the properties of intense twin beams is elucidated. The interference pattern formed in the process of sum-frequency generation and that of the Hong-Ou-Mandel interferometer are shown to be able to experimentally confirm the presence of coherent components.

  19. Idiopathic gynaecomastia in twins: a case report

    Directory of Open Access Journals (Sweden)

    S.V. Kumar

    2014-08-01

    Full Text Available Gynaecomastia is a common pathological condition of breast seen in men. This is defined as benign enlargement of breast tissue in males. It was first described by Palus Aegineta (AD 635-690. Herewith we are presenting cases of 14 year old twins attending the surgical O.P.D with bilateral enlarged breasts and pain. A diagnosis of pubertal gynaecomastia was made with no evidence of malignancy by histopathological examinations and mammography. One boy with 5 x 6 cm of right breast and 2 x3 cm of left breast was treated by subcutaneous mastectomy. Other boy had only enlargement of nipple and areola. He was reassured and sent home without surgical intervention. A rare case of idiopathic gynaecomastia in pubertal twins is described here. [Int J Res Med Sci 2014; 2(4.000: 1755-1757

  20. Low-noise macroscopic twin beams

    Science.gov (United States)

    Iskhakov, Timur Sh.; Usenko, Vladyslav C.; Filip, Radim; Chekhova, Maria V.; Leuchs, Gerd

    2016-04-01

    Applying a multiphoton-subtraction technique to the two-color macroscopic squeezed vacuum state of light generated via high-gain parametric down-conversion we conditionally prepare a different state of light: bright multimode low-noise twin beams. A lower noise in the sum of the photon numbers opens a possibility to encode information into this variable while keeping the nonclassical character of the state. The obtained results demonstrate up to eightfold suppression of noise in each beam while preserving and even moderately improving the nonclassical photon-number correlations between the beams. The prepared low-noise macroscopic state, containing up to 2000 photons per mode, is not among the Gaussian states achievable through nonlinear optical processes. Apart from that, we suggest a method for measuring quantum efficiency, which is based on the Fano factor measurement. The proposed technique substantially improves the usefulness of twin beams for quantum communication and metrology.

  1. Infantile systemic hyalinosis in identical twins.

    Science.gov (United States)

    Koonuru, Mahesh Kumar; Venugopal, Satya Prasad

    2015-11-01

    Infantile systemic hyalinosis (ISH) is a rare disorder belonging to the heterogeneous group of genetic fibromatoses. It is a rare, progressive, fatal autosomal recessive condition characterized by widespread deposition of hyaline material in many tissues caused by mutations in the anthrax toxin receptor 2 gene - ANTXR2. It presents hyperpigmented skin over bony prominences. Characteristic purplish patches develop over the medial and lateral malleoli of the ankles, the metacarpophalangeal joints, spine and elbows, with progressive joint contractures, osteopenia, skin abnormalities and chronic severe pain. The present case reports the occurrence of infantile systemic hyalinosis in twin brothers five months of age who had come for early intervention for joint contractures representing characteristic brownish patches over bony prominences. ISH cases reported until this date have been less than 20 and the present case is unique in nature since this is the first time ISH is reported in twins globally and the symptoms have been identified at an early age. PMID:26668783

  2. The Twin Higgs mechanism and Composite Higgs

    CERN Document Server

    Low, Matthew; Wang, Lian-Tao

    2015-01-01

    We combine the Twin Higgs mechanism with the paradigm of Composite Higgs models. In this class of models the Higgs is a pseudo-Nambu-Goldstone boson from a strongly coupled sector near the TeV scale, and it is additionally protected by a discrete symmetry due to the twin mechanism. We discuss the model building issues associated with this setup and quantify the tuning needed to achieve the correct electroweak vacuum and the Higgs mass. In contrast to standard Composite Higgs models, the lightest resonance associated with the top sector is the uncolored mirror top, while the colored top partners can be made parameterically heavier without extra tuning. In some cases, the vector resonances are predicted to lie in the multi-TeV range. We present models where the resonances - both fermions and vectors - being heavier alleviates the pressure on naturalness coming from direct searches demonstrating that theories with low tuning may survive constraints from the Large Hadron Collider.

  3. Twin-twin transfusion syndrome: cerebral ischemia is not the only fetal MR imaging finding

    International Nuclear Information System (INIS)

    Twin-twin transfusion syndrome (TTTS) is a complication of monochorionic/diamniotic twin pregnancies. An imbalance of blood flow occurs through placental anastomoses, causing potentially significant morbidity and mortality in both twins. Although the sonographic findings of TTTS are well documented, we believe that MR imaging is a valuable adjunct. We describe the fetal MR imaging findings associated with TTTS. From 2003 to 2005, 37 consecutive MR imaging studies were performed on multiple-gestation pregnancies. Of the 37, 25 were consistent with TTTS, correlated and confirmed by sonographic criteria. MR fetal abnormalities were documented. Cerebral ischemia, which could not be demonstrated by sonography, was delineated well by MR imaging. New findings noted on fetal MR imaging were enlargement of cerebral venous sinuses in both twins, dilatation of the renal collecting system in the recipient, lung lesions in the recipient and cerebral malformations in the donor. MR imaging is an important adjunct in TTTS imaging. Its benefit over sonography is its clear definition of cerebral pathology, which is important for intervention and counseling. The new findings, particularly in the urinary tract and cerebral venous sinuses, also help support the diagnosis of TTTS and might reveal additional consequences of the altered hemodynamics that occur in TTTS. (orig.)

  4. Marital status and twins' health and behavior: an analysis of middle-aged Danish twins

    DEFF Research Database (Denmark)

    Osler, Merete; McGue, Matt; Lund, Rikke;

    2008-01-01

    OBJECTIVE: To disentangle the influences on health of selection processes related to genetic and rearing environmental factors from factors related to marriage benefits. We compared health status among same-sex male and female twin pairs who lived together during childhood and were discordant or ...... divorce with depression and smoking in Danish twins are due to the stressful effects of marital dissolution, but that marital differences in other health and behavioral outcomes are most consistent with selection effects related to genetic or rearing environmental factors.......OBJECTIVE: To disentangle the influences on health of selection processes related to genetic and rearing environmental factors from factors related to marriage benefits. We compared health status among same-sex male and female twin pairs who lived together during childhood and were discordant...... or concordant on adult marital status. METHODS: A cross-sectional survey of a random sample of middle-aged Danish twins was conducted in 1998 to 1999. This study included 1175 same-sex twin pairs (52.5% monozygotic (MZ) and 47.5% dizygotic (DZ)). Data were obtained on adult marital status and on height, body...

  5. 2.6. Sorption of serum albumin by ethynyl-piperidol hydrogels

    International Nuclear Information System (INIS)

    The sorption of serum albumin by ethynyl-piperidol hydrogels was studied in this article. Albumins adsorption on the surface of solids was considered. The capacity of cross-linked ethynyl piperidol polymers to the serum albumin was considered as well. The kinetic curves of sorption of human serum albumin by triple copolymer of isopropenyl trimethyl ethynyl piperidol were constructed. Sorption activity of ethynyl-piperidol polymers depending on ph of solution of human serum albumin were defined. Influence of solution ionic strength on sorption of human serum albumin was defined as well. The desorption of human serum albumin from the complexes with hydrogels was examined.

  6. Gemcitabine-loaded magnetic albumin nanospheres for cancer chemohyperthermia

    International Nuclear Information System (INIS)

    Eliminating cancer without harming normal body tissue remains a longstanding challenge in medicine. Toward this goal, we prepared nanosized magnetic albumin nanospheres encapsulating magnetic nanoparticles (Fe3O4) and antitumor drugs (Gemcitabine, GEM). Magnetic albumin nanospheres (average size ≈ 224 nm) had good magnetic responsiveness upon exposure to an alternating magnetic field even though Fe3O4 was encased in nanospheres. Thermodynamic test showed that Fe3O4 could serve as a heating source under AMF and lead the nanospheres to reach their steady temperature (45 °C). The release results in vitro indicated that nanospheres had an obvious effect of sustained release of GEM. The result of cytotoxicity assay showed that the toxicity of this material was classified as grade 1, which belongs to no cytotoxicity. The antitumor efficacy of the GEM/Fe3O4 albumin nanospheres combined with magnetic fluid hyperthermia on non-small lung cancer cell line GlC-82 was examined by MTT assay and flow cytometry assay. Compared with nanospheres entrapping GEM group, nanospheres entrapping Fe3O4 combined with MFH group, and GEM/Fe3O4 albumin nanospheres without MFH group, the GEM/Fe3O4 albumin nanospheres exhibited enhanced antitumor efficacy. Thus, the GEM/Fe3O4 albumin nanospheres have promising applications in cancer treatment.

  7. CONJOINED TWIN CALF IN A BUFFALO

    Directory of Open Access Journals (Sweden)

    Maqbool Ahmad, A. Khan1 and H.A. Samad

    2001-07-01

    Full Text Available The present case was a conjoined female twin calf joined at thorax having symmetrical two heads, two necks, four forelimbs, two hind limbs, single belly, distally separated two tails and single vulva (Dicephalus dipus tetrabrachius. When skin was incised and thoracic and abdominal cavities were opened, partial bifurcation of thoracic to lumbar vertebrae was observed. There were incompletely doubled lungs and hearts. The two esophagi joined .the common gastrointestinal tract. The urogenital system was single.

  8. Optical Properties of Rotationally Twinned Nanowire Superlattices

    DEFF Research Database (Denmark)

    Bao, Jiming; Bell, David C.; Capasso, Federico;

    2008-01-01

    We have developed a technique so that both transmission electron microscopy and microphotoluminescence can be performed on the same semiconductor nanowire over a large range of optical power, thus allowing us to directly correlate structural and optical properties of rotationally twinned zinc...... a heterostructure in a chemically homogeneous nanowire material and alter in a major way its optical properties opens new possibilities for band-structure engineering....

  9. Emergency separation of a xipho-omphalopagus twin in a developing country

    Directory of Open Access Journals (Sweden)

    Shukla R

    2010-01-01

    Full Text Available Female conjoined twins (thoraco-omphalopagus were delivered by emergency caesarean section in a private nursing home. On examination, one of the twins was dead and was threatening the survival of the surviving twin (twin A. An emergency separation was performed to salvage the surviving twin.

  10. Thoracopagus conjoined twins: a case report

    Directory of Open Access Journals (Sweden)

    Rabi Narayan Satpathy

    2015-10-01

    Full Text Available 25 yr. old, G2P1 presented with premature labour pains at 33wks 3d of gestation and was referred to our tertiary centre as a suspected case of conjoined twin pregnancy based on a sonography report which revealed fetus with two heads Decision in favour of LSCS was taken after counselling the patient and her attendants regarding the anomaly of the fetus and incompatibility of life and dangers of spontaneous vaginal delivery. LSCS was done with delivery of first twin by cephalic and second twin by breech extraction, both were preterm male babies joined anteriorly starting from thorax to umbilicus (Thoracopagus with four arms and four legs, baby could not be revived and was declared clinically dead in few minutes by neonatologist,. Photographs were taken and we tried to obtain consent for autopsy but attendants were reluctant. A review of the literature suggests that early diagnosis by a combination of ultrasound and MRI is essential to management, providing prognosis for viability and success of surgical separation and the opportunity for early counselling of parents and termination if indicated. [Int J Reprod Contracept Obstet Gynecol 2015; 4(5.000: 1577-1580

  11. The flavor of the Composite Twin Higgs

    Science.gov (United States)

    Csáki, Csaba; Geller, Michael; Telem, Ofri; Weiler, Andreas

    2016-09-01

    The assumption of anarchic quark flavor puts serious stress on composite Higgs models: flavor bounds imply a tuning of a few per-mille (at best) in the Higgs potential. Composite twin Higgs (CTH) models significantly reduce this tension by opening up a new region of parameter space, obtained by raising the coupling among the composites close to the strong coupling limit g ∗ ˜ 4π, thereby raising the scale of composites to around 10 TeV. This does not lead to large tuning in the Higgs potential since the leading quantum corrections are canceled by the twin partners (rather than the composites). We survey the leading flavor bounds on the CTH, which correspond to tree-level Δ F = 2 four-Fermi operators from Kaluza-Klein (KK) Z exchange in the kaon system and 1-loop corrections from KK fermions to the electric dipole moment of the neutron. We provide a parametric estimate for these bounds and also perform a numeric scan of the parameter space using the complete calculation for both quantities. The results confirm our expectation that CTH models accommodate anarchic flavor significantly better than regular composite Higgs (CH) models. Our conclusions apply both to the identical and fraternal twin cases.

  12. CLINICAL STUDY OF LABOUR IN TWIN PREGNANCY

    Directory of Open Access Journals (Sweden)

    Amudha

    2015-07-01

    Full Text Available OBJECTIVES: The objective of the present study is to analyse the incidence of preterm labour, intrapartum complications, incidence of operative delivery both vaginal and cesarean and indications for such interventions. METHODOLOGY: A total of 150 cases of twin pregnancy were analyzed between the period of September 2012 to February 2014. These cases were stud ied with respect to period of gestation at the onset of labour, fetal presentations at the onset of labour, route and mode of delivery, indications in cases of cesarean delivery, intrapartum complications and delivery interval between twins. OBSERVATIONS A ND RESULTS: In the present study there was increased incidence of preterm labour (52.6%, fetal malpresentations (43.3%, operative vaginal delivery (29.5%, cesarean delivery (17.3%. CONCLUSION: In this study it is observed that above mentioned labour ev ents and complications double up in the event of a twin pregnancy. Regular antenatal visits, planned delivery and anticipation and identification of complications will help for better pregnancy outcome.

  13. Anorexia and Bulimia Nervosa in Same-Sex and Opposite-Sex Twins : Lack of Association With Twin Type in a Nationwide Study of Finnish Twins

    NARCIS (Netherlands)

    Raevuori, Anu; Kaprio, Jaakko; Hoek, Hans W.; Sihvola, Elina; Rissanen, Aila; Keski-Rahkonen, Anna

    2008-01-01

    Objective: The authors tested the hypothesis that either prenatal feminization or masculinization hormone influences in utero or later socialization affects the risk for anorexia and bulimia nervosa and disordered eating in members of opposite-sex twin pairs. Method: Finnish twins (N=2,426 women, N=

  14. Quantitative aspects of phosphorus absorption and excretion in horses

    Energy Technology Data Exchange (ETDEWEB)

    Bueno, Ives Claudio da Silva; Abdalla, Adibe Luiz; Vitti, Dorinha Miriam Silber Schmidt [Centro de Energia Nuclear na Agricultura (CENA), Piracicaba, SP (Brazil). Lab. de Nutricao Animal]. E-mails: icsbueno@cena.usp.br; abdalla@cena.usp.br; dovitti@cena.usp.br; Furtado, Carlos Eduardo [Universidade Estadual de Maringa, PR (Brazil). Dept. de Zootecnia]. E-mail: cefurtado@uem.br

    2007-07-01

    Phosphorus (P) is one of the most polluting nutrients because of high husbandry concentrations in restricted areas. The present study compiles data from previous studies dealing with true digestibility of different P levels in diets for horses. Database consisted of results from two experiments carried out at the Centre for Nuclear Energy in Agriculture (CENA/USP), using horses fed different levels of P (n=28). True absorption of phosphorus was determined by isotopic dilution technique, using {sup 32}P as tracer. All parameters (P{sub ING}: ingested P; P{sub ABS}: absorbed P; P{sub FECTOT}: total faecal P excretion; P{sub FECENDO}: endogenous faecal P; P{sub URI}: total urinary excretion; and P{sub RET}: retained P) were normalized according to body weight (BW) and linear and quadratic regressions between P{sub ING} and the other parameters were tested. No quadratic effect was observed. P{sub ING} ranged from 41 to 264 mg/kg BW. Faecal P excretion was affected by intake, analysing by total (P{sub FECTOT} = 0.888 (S.E. 0.058) P{sub ING} - 29.40 (S.E. 8.14) (P<0.0001; RMSE=20.37; R{sup 2}=0.90) or by endogenous fraction (P{sub FECENDO} = 0.095 (S.E. 0.029) P{sub ING} + 12.10 (S.E. 4.16) (P=0.0034; RMSE=10.41; {sup R}2=0.29). Urinary P excretion was not affected by intake (P=0.35), although ranging from 0.06 to 59.20 mg/kg BW. The same occurred for P{sub RET} (P=0.25) ranging from -13.69 to 88.78 mg/kg BW. P absorption also was affect by P intake (P{sub ABS} = 0.195 (S.E. 0.060) P{sub ING} + 42.19 (S.E. 8.45) (P=0.0031; RMSE=21.15; R{sup 2}=0.29). The present study showed that only a small part of ingested P was absorbed, i.e. most of ingested P was excreted via faeces, contributing for environmental pollution. (author)

  15. Fluorescence lifetime measurements of native and glycated human serum albumin and bovine serum albumin

    Science.gov (United States)

    Joshi, Narahari V.; Joshi, Virgina O. d.; Contreras, Silvia; Gil, Herminia; Medina, Honorio; Siemiarczuk, Aleksander

    1999-05-01

    Nonenzymatic glycation, also known as Maillard reaction, plays an important role in the secondary complications of the diabetic pathology and aging, therefore, human serum albumin (HSA) and bovine serum albumin (BSA) were glycated by a conventional method in our laboratory using glucose as the glycating agent. Fluorescence lifetime measurements were carried out with a laser strobe fluorometer equipped with a nitrogen/dye laser and a frequency doubler as a pulsed excitation source. The samples were excited at 295 nm and the emission spectra were recorded at 345 nm. The obtained decay curves were tried for double and triple exponential functions. It has been found that the shorter lifetime increases for glycated proteins as compared with that of the native ones. For example, in the case of glycated BSA the lifetime increased from 1.36 ns to 2.30 ns. Similarly, for HSA, the lifetime increases from 1.58 ns to 2.26 ns. Meanwhile, the longer lifetime changed very slightly for both proteins (from 6.52 ns to 6.72 ns). The increase in the lifetime can be associated with the environmental effect; originated from the attachment of glucose to some lysine residues. A good example is Trp 214 which is in the cage of Lys 225, Lys 212, Lys 233, Lys 205, Lys 500, Lys 199 and Lys 195. If fluorescence lifetime technique is calibrated and properly used it could be employed for assessing glycation of proteins.

  16. A low-protein diet restricts albumin synthesis in nephrotic rats.

    OpenAIRE

    Kaysen, G A; Jones, H.; Martin, V.; Hutchison, F N

    1989-01-01

    High-protein diets increase albumin synthesis in rats with Heymann nephritis but albuminuria increases also, causing serum albumin concentration to be suppressed further than in nephrotic animals eating a low-protein diet. Experiments were designed to determine whether dietary protein augmentation directly stimulates albumin synthesis, or whether instead increased albumin synthesis is triggered by the decrease in serum albumin concentration. Evidence is presented that dietary protein augmenta...

  17. Serum albumin induces iNOS expression and NO production in RAW 267.4 macrophages

    OpenAIRE

    Poteser, Michael; Wakabayashi, Ichiro

    2004-01-01

    We investigated the effects of serum albumin on inducible nitric oxide synthase (iNOS) expression in RAW 267.4 macrophages. Crude fraction-V type albumin as well as bovine serum albumin filtrated for endotoxin induced concentration-dependent iNOS expression in macrophages. Accordingly, NO production (estimated by supernatant nitrite) was markedly (up to 10-fold) increased in the presence of albumin.Albumin-induced expression of iNOS protein was inhibited by cycloheximide and NO production was...

  18. Twin-twin transfusion syndrome: neurodevelopment of infants treated with laser surgery.

    Science.gov (United States)

    Campos, Denise; Arias, Amabile V; Campos-Zanelli, Thatiane M; Souza, Daniela S; Santos Neto, Orlando G Dos; Peralta, Cleisson Fabio A; Guerreiro, Marilisa M

    2016-04-01

    Objective To assess the neurodevelopmental functions of survivors of twin-twin transfusion syndrome (TTTS) treated by fetoscopic laser coagulation (FLC), during the first year of life, comparing them to a control group; and to verify the influence of specific variables on neurodevelopment. Method This was a prospective, longitudinal study. The sample comprised 33 monochorionic diamniotic twins who underwent FLC for treatment of TTTS and 22 full-term infants of single-fetus pregnancies. Bayley Scales of Infant and Toddler Development Screening Test were used for evaluation. Prenatal, perinatal and postnatal information were obtained. Results There was an increased frequency of infants in the TTTS group with inadequate performance compared to the control group. The identified variables (fetal donor, low economic income and cardiorespiratory disease) negatively impacted expressive communication and fine motor skills. Conclusion Although through follow-up is recommended in all TTTS survivors, particular attention is required for the high-risk group as defined in this study. PMID:27097004

  19. Occurrence of twin embryos in the eastern bluebird

    Directory of Open Access Journals (Sweden)

    Robyn L. Bailey

    2014-03-01

    Full Text Available We report the first record of presumed twinning in eastern bluebird (Sialia sialis and provide a review of previously reported twinning events in wild birds. A nest containing twin eastern bluebird nestlings was monitored in 2013 in central Pennsylvania and reported to the Cornell Lab of Ornithology’s NestWatch program, a national program where volunteers submit data on wild nesting birds. A presumed double-yolked egg of a free-living eastern bluebird pair hatched successfully, and twin nestlings lived for 11 days in a nest box shared by three siblings. Due to the rarity of twinning in wild birds, engaging the public to monitor large numbers of nests is the most likely approach to documenting twinning in wild populations, and citizen science provides the infrastructure for individuals to share observations.

  20. Confined Blood Chimerism in Monochorionic Dizygotic Twins Conceived Spontaneously

    Directory of Open Access Journals (Sweden)

    Takashi Kanda

    2013-05-01

    Full Text Available Traditionally, monochorionicity has been regarded as synonymous with monozygosity. However, several recent cases of monochorionic dizygotic twins have shown that monochorionic twins can be dizygous. We report a rare case of monochorionic diamnionic, gender-discordant twins who were conceived spontaneously. Initially, a monochorionic placenta was diagnosed by ultrasonography at 8 weeks of gestation and then confirmed by pathology after delivery. The twins had different genders. A comparison of cytogenetic analyses using peripheral blood lymphocytes and skin fibroblasts revealed that chimerism was confined to blood cells. We have experienced two cases of monochorionic dizygotic twins since 2003. These cases suggest that monochorionic dizygotic twins are not as rare as previously thought.

  1. Coffee and smoking as risk factors of twin pregnancies

    DEFF Research Database (Denmark)

    Morales-Suárez-Varela, Maria M; Bech, Bodil Hammer; Christensen, Kaare;

    2007-01-01

    Twinning rates have changed substantially over time for reasons that are only partly known. In this study we studied smoking, coffee and alcohol intake, and their possible interaction with obesity as potential determinants of twinning rates using data from the Danish National Birth Cohort between...... their prepregnancy weight and height, coffee and alcohol intake, smoking habits, and potential confounding factors at early stages of pregnancy. We identified smoking (> 10 cigarettes/day) as a possible determinant of twinning, particularly for dizygotic twinning rates (same sex) and furthermore corroborated...... that obesity and the mother's age are strong correlates of twinning. Others have found coffee intake to increase twinning rates but that is not seen in these data....

  2. Adolescent idiopathic scoliosis in twins: a population-based survey

    DEFF Research Database (Denmark)

    Andersen, Mikkel O; Thomsen, Karsten; Kyvik, Kirsten O

    2007-01-01

    STUDY DESIGN: A questionnaire-based identification of adolescent idiopathic scoliosis (AIS) patients in a twin cohort. OBJECTIVE: The purpose of this study was to establish a scoliosis twin cohort to provide data on the heritability of AIS. SUMMARY OF BACKGROUND DATA: The etiology of AIS is still...... environmental factors. METHODS: All 46,418 twins registered in the Danish Twin Registry born from 1931 to 1982 were sent a questionnaire, which included questions about scoliosis. A total of 34,944 (75.3%) representing 23,204 pairs returned the questionnaire. RESULTS: A subgroup of 220 subjects considered...... of monozygotic and dizygotic pairs was significantly different (P scoliosis in 1 twin whose other twin has scoliosis is smaller than believed up until now....

  3. CONSERVATIVE MANAGEMENT OF TWIN PREGNANCY WITH SINGLE FETAL DEATH

    Institute of Scientific and Technical Information of China (English)

    刘俊涛; 杨佳欣; 边旭明; 张羽

    2000-01-01

    Objective. Analysis of the cause of intrauterine death of one fetus of twin and to evaluate the outcome of conservative management of twin pregnancy with single fetal death. Method. A retrospective review was undertaken on PUMC hospital records of women who delivered twin between Jan. 1987 and Dec. 1998. Result. During the recent 12 years, 99 pregnant women were documented as twin pregnancies. Of the twin pregnancies during this period, 13 were complicated by a single intrauterine death. Four women suffered this complication during their first trimester. In the remain 9 cases one fetus died dm-ing second or third trimester.The cesarean section was given in three pregnant women soon after a single intrauterine death because of the survival fetal distress. No consumptive coagulopathy was apparent in all 13 pregnant women. It is wise that the pregnancy was managed conservatively, with regular coagulation parameters obtained. Condosion. Our results suptmrt conservative management in twin pregnancies complicated by single fetal death.

  4. CONSERVATIVE MANAGEMENT OF TWIN PREGNANCY WITH SINGLE FETAL DEATH

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective. Analysis of the cause of intrauterine death of one fetus of twin and to evaluate the outcome of conservative management of twin pregnancy with single fetal death.Method.A retrospective review was undertaken on PUMC hospital records of women who delivered twin between Jan. 1987 and Dec. 1998.Result.During the recent 12 years, 99 pregnant women were documented as twin pregnancies. Of the twin pregnancies during this period, 13 were complicated by a single intrauterine death. Four women suffered this complication during their first trimester. In the remain 9 cases one fetus died during second or third trimester. The cesarean section was given in three pregnant women soon after a single intrauterine death because of the survival fetal distress. No consumptive coagulopathy was apparent in all 13 pregnant women. It is wise that the pregnancy was managed conservatively, with regular coagulation parameters obtained.Conclusion.Our results support conservative management in twin pregnancies complicated by single fetal death.

  5. Crystallography of decahedral and icosahedral particles. I - Geometry of twinning

    Science.gov (United States)

    Yang, C. Y.

    1979-01-01

    The crystal structure of the tetrahedral twins in multiply-twinned particles with decahedral and icosahedral point group symmetries has been examined and correlated with the face-centered cubic structure. Details on the crystal structure as well as the geometrical relationships among twins in each particle are presented. These crystallographic facts serve as a basis for the interpretation of small particle images obtained with advanced methods of transmission electron microscopy.

  6. Macro deformation twins in single-crystal aluminum

    OpenAIRE

    Zhao, F.; Wang, L.; Fan, D.; B. X. Bie; Zhou, X. M.; Suo, T.; Y. L. Li; Chen, M. W.; Liu, C; Qi, M. L.; Zhu, M. H.; Luo, S. N.

    2015-01-01

    Deformation twinning in pure aluminum has been considered to be a unique property of nanostructured aluminum. A lingering mystery is whether deformation twinning occurs in coarse-grained or single-crystal aluminum, at scales beyond nanotwins. Here, we present the first experimental demonstration of macro deformation twins in single-crystal aluminum formed under ultrahigh strain-rate ($\\sim$10$^6$ s$^{-1}$), large shear strain (200$\\%$) via dynamic equal channel angular pressing. Deformation t...

  7. Genetic Influences on Pulmonary Function: A Large Sample Twin Study

    OpenAIRE

    Ingebrigtsen, T.S.; Thomsen, S.F.; Sluis, van der, B.; Miller, M; Christensen, K.; Sigsgaard, T.; Backer, V.

    2011-01-01

    Heritability of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and peak expiratory flow (PEF) has not been previously addressed in large twin studies. We evaluated the genetic contribution to individual differences observed in FEV1FVC, and PEF using data from the largest population-based twin study on spirometry. Specially trained lay interviewers with previous experience in spirometric measurements tested 4,314 Danish twins (individuals), 46–68 years of age, in t...

  8. Doppler velocimetry for predicting fetal death in a twin pregnancy.

    OpenAIRE

    Soikkeli, Pia; Dubiel, Mariusz; Gudmundsson, Saemundur

    2002-01-01

    Diagnosis of discordant twins is easily accomplished with modern ultrasound equipment, though diagnosing twin-to-twin transfusion syndrome (TTS) at an early stage might be a problem. The possibility of excluding TTS by Doppler ultrasound is demonstrated in a case with early severe growth restriction of one fetus. Characteristic blood velocity changes in a dying fetus are also illustrated. The Doppler technique has become an accepted method in obstetrics for antenatal surveillance, perm...

  9. Marital Conflict and Conduct Problems in Children of Twins

    OpenAIRE

    Harden, K. Paige; Turkheimer, Eric; Emery, Robert E.; D’Onofrio, Brian M; Slutske, Wendy S.; Andrew C Heath; Martin, Nicholas G.

    2007-01-01

    The Children-of-Twins design was used to test whether associations between marital conflict frequency and conduct problems can be replicated within the children of discordant twin pairs. A sample of 2,051 children (age 14–39 years) of 1,045 twins was used to estimate the genetic and environmental influences on marital conflict and determine whether genetic or environmental selection processes underlie the observed association between marital conflict and conduct problems. Results indicate tha...

  10. Twinning in copper deformed at high strain rates

    Indian Academy of Sciences (India)

    S Cronje; R E Kroon; W D Roos; J H Neethling

    2013-02-01

    Copper samples having varying microstructures were deformed at high strain rates using a split-Hopkinson pressure bar. Transmission electron microscopy results show deformation twins present in samples that were both annealed and strained, whereas samples that were annealed and left unstrained, as well as samples that were unannealed and strained, are devoid of these twins. These deformation twins occurred at deformation conditions less extreme than previously predicted.

  11. Personality development in monozygotic twins of varying IQ discordance

    OpenAIRE

    Salomonsson, Sally

    2013-01-01

    The present study sought to investigate the personality-intelligence association by using longitudinal MZ twin data to examine if intelligence and personality are developmentally linked. If twins discordant for IQ in childhood grew up to differ more in personality than twins of very similar intelligence, it would support theories of personality and intelligence that posit a developmental interaction between the two and a non-shared environmental influence can be inferred. It was also investiga...

  12. Extracting twins from orientation imaging microscopy scan data.

    Science.gov (United States)

    Wright, S I; Larsen, R J

    2002-03-01

    Automated electron backscatter diffraction or orientation imaging microscopy (OIM) provides spatially specific measurements of crystallographic orientation. These measurements are typically collected on regular grids. By inspecting the misorientation between neighbouring measurements on the grid, potential twin boundaries can be identified. If the misorientation is within some given tolerance of a specified twin misorientation, the boundary separating the two measurements may be identified as a potential twin boundary. In addition, for a coherent twin, the twinning planes must be coincident with the grain boundary plane. As OIM scans are inherently two-dimensional, the scan data provide only limited information on the boundary plane. Thus, it is not possible to ascertain definitively whether the twinning planes are coincident with the boundary plane. Nonetheless, the alignment of the surface traces of the twinning planes with the trace of the boundary provides a partial indication of coincidence. An automated approach has been developed that allows data concerning both twin criterion to be extracted from OIM scans. Application of the methodology to deformed zirconium suggests that the twinning planes remain coherent during deformation. The methodology was also used to improve grain size distributions measured by OIM. These results more closely match those obtained by conventional metallography. PMID:11996188

  13. Maternal serum alpha fetoprotein in monozygotic and dizygotic twin pregnancies.

    Science.gov (United States)

    Thom, H; Buckland, C M; Campbell, A G; Thompson, B; Farr, V

    1984-01-01

    Maternal serum alpha-fetoprotein (MSAFP) values in the second trimester have been related to pregnancy outcome for 100 normal twin pairs, 42 monozygous (MZ) and 58 dizygous (DZ), liveborn after 28 weeks gestation. The median MSAFP value was 1.9 multiples of the median value (MOM) for uncomplicated singleton pregnancies. Both very low and very high MSAFP values were associated with twins of low birthweight. MSAFP values were higher in MZ than DZ twin pregnancies particularly those with dizygotes of like-sex. This effect was even more marked when only dichorionic like-sex twin pairs were compared. PMID:6209699

  14. Terahertz Detection with Twin Superconductor-Insulator-Superconductor Tunnel Junctions

    Institute of Scientific and Technical Information of China (English)

    LI Jing; WANG Ming-Jye; SHI Sheng-Cai; Hiroshi Mat-suo

    2007-01-01

    Terahertz detection with twin superconductor-insulator-superconductor (SIS) tunnel junctions, which are connected in parallel via an inductive thin-film superconducting microstrip line, is mainly studied. Firstly, we investigate the direct-detection response of a superconducting twin-junction device by means of a Fourier transform spectrometer. Secondly, we construct a direct-detection model of twin SIS tunnel junctions. The superconducting twin-junction device is then simulated in terms of the constructed model. The simulation result is found to be in good agreement with the measured one. In addition, we observe that the direct-detection response of the device is consistent with the noise temperature behaviour.

  15. The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers

    DEFF Research Database (Denmark)

    Willemsen, G.; Ward, K. J.; Bell, C. G.;

    2015-01-01

    studies worldwide need to pool their resources. The Discordant Twin (DISCOTWIN) consortium was established for this goal. Here, we describe the DISCOTWIN Consortium and present an analysis of type 2 diabetes (T2D) data in nearly 35,000 twin pairs. Seven twin cohorts from Europe (Denmark, Finland, Norway...... and medication use, fasting glucose and insulin measures, or medical records. The prevalence of T2D ranged from 2.6% to 12.3% across the cohorts depending on age, body mass index (BMI), and national diabetes prevalence. T2D discordance rate was lower for MZ (5.1%, range 2.9-11.2%) than for same-sex dizygotic (DZ......Twin pairs discordant for disease may help elucidate the epigenetic mechanisms and causal environmental factors in disease development and progression. To obtain the numbers of pairs, especially monozygotic (MZ) twin pairs, necessary for in-depth studies while also allowing for replication, twin...

  16. Serum Albumin Levels and Economic Status in Japanese Older Adults

    Science.gov (United States)

    Ota, Asami; Kondo, Naoki; Murayama, Nobuko; Tanabe, Naohito; Shobugawa, Yugo; Kondo, Katsunori

    2016-01-01

    Background Low serum albumin levels are associated with aging and medical conditions such as cancer, liver dysfunction, inflammation, and malnutrition and might be an independent predictor of long-term mortality in healthy older populations. We tested the hypothesis that economic status is associated with serum albumin levels and explained by nutritional and health status in Japanese older adults. Design We performed a cross-sectional analysis using data from the Japan Gerontological Evaluation study (JAGES). The study participants were 6528 functionally independent residents (3189 men and 3339 women) aged ≥65 years living in four municipalities in Aichi prefecture. We used household income as an indicator of economic status. Multiple linear regression was used to compare serum albumin levels in relation to household income, which was classified as low, middle, and high. Additionally, mediation by nutritional and health-related factors was analyzed in multivariable models. Results With the middle-income group as reference, participants with low incomes had a significantly lower serum albumin level, even after adjustment for sex, age, residential area, education, marital status, and household structure. The estimated mean difference was −0.17 g/L (95% confidence interval, −0.33 to −0.01 g/L). The relation between serum albumin level and low income became statistically insignificant when “body mass index”, “consumption of meat or fish”, “self-rated health”, “presence of medical conditions”, “hyperlipidemia”, or “respiratory disease “was included in the model. Conclusion Serum albumin levels were lower in Japanese older adults with low economic status. The decrease in albumin levels appears to be mediated by nutrition and health-related factors with low household incomes. Future studies are needed to reveal the existence of other pathways. PMID:27276092

  17. Serum Albumin Levels and Economic Status in Japanese Older Adults.

    Directory of Open Access Journals (Sweden)

    Asami Ota

    Full Text Available Low serum albumin levels are associated with aging and medical conditions such as cancer, liver dysfunction, inflammation, and malnutrition and might be an independent predictor of long-term mortality in healthy older populations. We tested the hypothesis that economic status is associated with serum albumin levels and explained by nutritional and health status in Japanese older adults.We performed a cross-sectional analysis using data from the Japan Gerontological Evaluation study (JAGES. The study participants were 6528 functionally independent residents (3189 men and 3339 women aged ≥65 years living in four municipalities in Aichi prefecture. We used household income as an indicator of economic status. Multiple linear regression was used to compare serum albumin levels in relation to household income, which was classified as low, middle, and high. Additionally, mediation by nutritional and health-related factors was analyzed in multivariable models.With the middle-income group as reference, participants with low incomes had a significantly lower serum albumin level, even after adjustment for sex, age, residential area, education, marital status, and household structure. The estimated mean difference was -0.17 g/L (95% confidence interval, -0.33 to -0.01 g/L. The relation between serum albumin level and low income became statistically insignificant when "body mass index", "consumption of meat or fish", "self-rated health", "presence of medical conditions", "hyperlipidemia", or "respiratory disease "was included in the model.Serum albumin levels were lower in Japanese older adults with low economic status. The decrease in albumin levels appears to be mediated by nutrition and health-related factors with low household incomes. Future studies are needed to reveal the existence of other pathways.

  18. Albumin Dialysis for Liver Failure: A Systematic Review.

    Science.gov (United States)

    Tsipotis, Evangelos; Shuja, Asim; Jaber, Bertrand L

    2015-09-01

    Albumin dialysis is the best-studied extracorporeal nonbiologic liver support system as a bridge or destination therapy for patients with liver failure awaiting liver transplantation or recovery of liver function. We performed a systematic review to examine the efficacy and safety of 3 albumin dialysis systems (molecular adsorbent recirculating system [MARS], fractionated plasma separation, adsorption and hemodialysis [Prometheus system], and single-pass albumin dialysis) in randomized trials for supportive treatment of liver failure. PubMed, Ovid, EMBASE, Cochrane's Library, and ClinicalTrials.gov were searched. Two authors independently screened citations and extracted data on patient characteristics, quality of reports, efficacy, and safety end points. Ten trials (7 of MARS and 3 of Prometheus) were identified (620 patients). By meta-analysis, albumin dialysis achieved a net decrease in serum total bilirubin level relative to standard medical therapy of 8.0 mg/dL (95% confidence interval [CI], -10.6 to -5.4) but not in serum ammonia or bile acids. Albumin dialysis achieved an improvement in hepatic encephalopathy relative to standard medical therapy with a risk ratio of 1.55 (95% CI, 1.16-2.08) but had no effect survival with a risk ratio of 0.95 (95% CI, 0.84-1.07). Because of inconsistency in the reporting of adverse events, the safety analysis was limited but did not demonstrate major safety concerns. Use of albumin dialysis as supportive treatment for liver failure is successful at removing albumin-bound molecules, such as bilirubin and at improving hepatic encephalopathy. Additional experience is required to guide its optimal use and address safety concerns. PMID:26311600

  19. Magnetic Resonance Imaging of the Feto-Placentar Unit after Fetoscopic Laser Coagulation for Twin-to-Twin Transfusion Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Huisman, T.A.G.M. [Univ. Children' s Hospital Zuerich (Switzerland). Dept. of Diagnostic Imaging; Lewi, L.; Willi, U.V.; Deprest, J. [Univ. Hospital Gasthuisberg, Leuven (Belgium). Dept. of Obstetrics-Gynaecology; Zimmermann, R. [Univ. Hospital Zurich (Switzerland). Dept. of Obstetrics

    2005-05-01

    Twin-to-twin transfusion syndrome (TTTS) is a severe complication in monochorionic twin pregnancies that results from a hemodynamical imbalance of placentar vascular anstomoses that connect the circulation of both fetuses. In TTTS, a poly/oligohydramnios sequence with high fetal morbidity and mortality rates occurs. Fetoscopic laser coagulation of the placentar anastomoses can limit or prevent fetal injury. The purpose of this report is to present and discuss fetal magnetic resonance imaging as a postoperative imaging tool after fetoscopic laser coagulation.

  20. Magnetic Resonance Imaging of the Feto-Placentar Unit after Fetoscopic Laser Coagulation for Twin-to-Twin Transfusion Syndrome

    International Nuclear Information System (INIS)

    Twin-to-twin transfusion syndrome (TTTS) is a severe complication in monochorionic twin pregnancies that results from a hemodynamical imbalance of placentar vascular anstomoses that connect the circulation of both fetuses. In TTTS, a poly/oligohydramnios sequence with high fetal morbidity and mortality rates occurs. Fetoscopic laser coagulation of the placentar anastomoses can limit or prevent fetal injury. The purpose of this report is to present and discuss fetal magnetic resonance imaging as a postoperative imaging tool after fetoscopic laser coagulation

  1. A Case of Monozygotic Twins: The Value of Discordant Monozygotic Twins in Goldenhar Syndrome—OMIM%164210

    Directory of Open Access Journals (Sweden)

    K. N. Venkateshwara Prasad

    2013-01-01

    Full Text Available Goldenhar syndrome is a rare developmental disorder characterised by hemifacial microsomia, epibulbar tumours, ear malformation, and vertebral anomalies. As monozygotic (MZ twins are believed to be genetically identical, discordance for disease phenotype between MZ twins varies with craniofacial anomalies, cardiac, vertebral, and central nervous system defects sporadically. We report a case of monozygotic female twins discordant for Goldenhar syndrome with hemifacial microsomia and the dysplasia of auricular pinna.

  2. Dysmorphism in One of a Set of Male Twins; Could They have been Identical Twins? A Diagnostic Dilemma.

    Science.gov (United States)

    Ibrahim, Aliyu

    2014-07-01

    Twinning occurs worldwide, but Nigerian women of the southwest extraction record one of the highest rates in the world. Among the notable risk factors for fraternal twinning is advanced maternal age, which is also an independent risk factor for Down syndrome. Even as morphological characteristics can easily be applied to distinguish identical from fraternal twins, in cases of an associated dysmorphism, in any member of the couplet, it becomes a difficult tool to use, as has been observed in the case of a set of twins who were of the same sex, blood group, hemoglobin genotype, and shared the same placenta. PMID:25374872

  3. Using egg albumin foam to extinguish fires

    Directory of Open Access Journals (Sweden)

    Hytham A. Alsaati

    2003-12-01

    Full Text Available Oil, coal and chemical fires are often difficult to put out using water. In certain hydrocarbon fires, protein foam can extinguish fires better than water by keeping air (oxygen away from the flames and by ''blowing'' the flame away from its fuel source. Egg albumin is a relatively inexpensive protein and is representative of foaming proteins, which are candidates for use as fire suppression agents. This paper begins to deal with the effect of the foam bulk pH, foam protein concentration and generating air flow rate into the foam on the fire extinguishing time in laboratory experiments. A Bunsen burner was used to generate a small, controlled laboratory fire within a plastic container, which represented a point source in a partially open room in the experiments. The Bunsen burner represents a gaseous hydrocarbon fire, which can be difficult to extinguish. Both a low pH foam and one made with a high air flow rate favor a reduction in time required to put out the Bunsen burner flame.Chamas produzidas por óleo, carvão e produtos químicos (incêndios provocados são difíceis de ser extinguidos com água. Algumas chamas de hidrocarbonetos podem ser extinguidas por espumas protéicas melhor do que a manutenção de ar (oxigênio fora do alcance das chamas ou pelo sopramento da chama para longe da sua fonte. Albumina de ovo é uma proteína relativamente barata e é representativa dentre as proteínas usadas como espuma para a (supressão extinção de agentes causadores de incêndio. Este artigo trata do estudo do efeito do pH e concentração da espuma protéica, além da geração de ar no interior da espuma, sobre o tempo de extinção de incêndio em experimentos laboratoriais. Nos experimentos um bico de Bunsen foi usado para gerar uma pequena chama, controlada em um container de plástico, representando uma fonte pontual em um ambiente parcialmente aberto. A chama do bico de Bunsen representa uma chama gasosa de hidrocarbonetos, que são dif

  4. [Immunohistochemical study on the mechanism of excretion of methamphetamine].

    Science.gov (United States)

    Kajitani, A; Kaiho, M; Mori, A; Okada, Y; Mukaida, M; Ishiyama, I

    1989-06-01

    Many methods of analysis are available to the forensic toxicologist for determining the amount of methamphetamine within human tissues, but few have the potential of histochemistry for enabling the precise site of excretion of methamphetamine to be defined. We have established a method for the demonstration of methamphetamine by immunohistochemistry, and applied this method for showing morphologically the disposition of methamphetamine. The following cells in the tissues of methamphetamine-intoxicated mice gave a strong positive reaction of the localization, which was thought to be the histological evidence of excretion of this drug: epithelial cells of the distal part of the renal tubule and of the collecting tubule, transitional epithelial cells of the bladder, liver parenchymal cells, epithelial cells of the striated duct of the salivary gland, parietal cells of the gastric gland, part of epithelial cells of the distal portion of the large intestine, secretory cells and part of epithelial cells of the ductal portion of the sweat gland, alveolar cells of the mammary gland, secretory cells of the sebaceous gland and hair medulla and cortex. These results indicated passive diffusion of methamphetamine across membranes of the cells of the distal tubule and collecting tubule of the kidney, of the bladder and of the striated duct of the salivary gland. In the parietal cells of the gastric gland, part of epithelial cells of the distal portion of the large intestine and secretory cells of the sweat gland, methamphetamine was thought to be stored and subsequently released. In the mammary gland, methamphetamine was found to be combined with casein and excreted by exocytosis. Accumulation of methamphetamine in the hair was supposed to be chiefly due to the penetration of this drug derived from tissue fluid and sebum.

  5. Iron excretion in iron dextran-overloaded mice

    Science.gov (United States)

    Musumeci, Marco; Maccari, Sonia; Massimi, Alessia; Stati, Tonino; Sestili, Paola; Corritore, Elisa; Pastorelli, Augusto; Stacchini, Paolo; Marano, Giuseppe; Catalano, Liviana

    2014-01-01

    Background Iron homeostasis in humans is tightly regulated by mechanisms aimed to conserve iron for reutilisation, with a negligible role played by excretory mechanisms. In a previous study we found that mice have an astonishing ability to tolerate very high doses of parenterally administered iron dextran. Whether this ability is linked to the existence of an excretory pathway remains to be ascertained. Materials and methods Iron overload was generated by intraperitoneal injections of iron dextran (1 g/kg) administered once a week for 8 weeks in two different mouse strains (C57bl/6 and B6D2F1). Urinary and faecal iron excretion was assessed by inductively coupling plasma-mass spectrometry, whereas cardiac and liver architecture was evaluated by echocardiography and histological methods. For both strains, 24-hour faeces and urine samples were collected and iron concentration was determined on days 0, 1 and 2 after iron administration. Results In iron-overloaded C57bl/6 mice, the faecal iron concentration increased by 218% and 157% on days 1 and 2, respectively (p<0.01). The iron excreted represented a loss of 14% of total iron administered. Similar but smaller changes was also found in B6D2F1 mice. Conversely, we found no significant changes in the concentration of iron in the urine in either of the strains of mice. In both strains, histological examination showed accumulation of iron in the liver and heart which tended to decrease over time. Conclusions This study indicates that mice have a mechanism for removal of excess body iron and provides insights into the possible mechanisms of excretion. PMID:24960657

  6. Crystallographic analysis reveals the structural basis of the high-affinity binding of iophenoxic acid to human serum albumin

    Directory of Open Access Journals (Sweden)

    Chung Chun-wa

    2011-04-01

    Full Text Available Abstract Background Iophenoxic acid is an iodinated radiocontrast agent that was withdrawn from clinical use because of its exceptionally long half-life in the body, which was due in part to its high-affinity binding to human serum albumin (HSA. It was replaced by Iopanoic acid, which has an amino rather than a hydroxyl group at position 3 on the iodinated benzyl ring and, as a result, binds to albumin with lower affinity and is excreted more rapidly from the body. To understand how iophenoxic acid binds so tightly to albumin, we wanted to examine the structural basis of its interaction with HSA. Results We have determined the co-crystal structure of HSA in complex with iophenoxic acid at 2.75 Å resolution, revealing a total of four binding sites, two of which - in drugs sites 1 and 2 on the protein - are likely to be occupied at clinical doses. High-affinity binding of iophenoxic acid occurs at drug site 1. The structure reveals that polar and apolar groups on the compound are involved in its interactions with drug site 1. In particular, the 3-hydroxyl group makes three hydrogen bonds with the side-chains of Tyr 150 and Arg 257. The mode of binding to drug site 2 is similar except for the absence of a binding partner for the hydroxyl group on the benzyl ring of the compound. Conclusions The HSA-iophenoxic acid structure indicates that high-affinity binding to drug site 1 is likely to be due to extensive desolvation of the compound, coupled with the ability of the binding pocket to provide a full set of salt-bridging or hydrogen bonding partners for its polar groups. Consistent with this interpretation, the structure also suggests that the lower-affinity binding of iopanoic acid arises because replacement of the 3-hydroxyl by an amino group eliminates hydrogen bonding to Arg 257. This finding underscores the importance of polar interactions in high-affinity binding to albumin.

  7. Natural intake and excretion of thorium and uranium

    International Nuclear Information System (INIS)

    The natural content of the isotopes 238Th, 230Th and 232Th in faeces as well as 234U, 235U and 238U in drinking-water has been investigated by means of α-spectroscopy. The averaged total activity of thorium in faeces has been found to be 56,6 mBq per daily excretion, the activity of uranium in drinking water is reported to be 11.3 mBq/l. The results are in comparison with the existing data from Germany, but different to international suppositions as in UNSCEAR or ICRP 23. (orig.)

  8. Human urinary excretion of non-persistent environmental chemicals

    DEFF Research Database (Denmark)

    Frederiksen, Hanne; Jensen, Tina Kold; Jørgensen, Niels;

    2014-01-01

    ), triclosan (TCS), and parabens because of their anti-androgenic and/or estrogenic effects. Phthalates are plasticizers used in numerous industrial products. Bisphenol A is the main component of polycarbonate plastics and epoxy resins. Parabens and TCS are antimicrobial preservatives and other phenols...... limited. In Denmark, we have no survey programs for non-persistent environmental chemicals, unlike some countries such as the USA (NHANES) and Germany (GerES). However, we have analyzed the excretion of seven parabens, nine phenols, and the metabolites of eight different phthalates in urine samples...

  9. Pharmacokinetics: metabolism and renal excretion of quinolones in man.

    Science.gov (United States)

    Vree, T B; Wijnands, W J; Guelen, P J; Baars, A M; Hekster, Y A

    1986-02-21

    The quinolones are relatively poorly absorbed from the gastrointestinal tract. The elimination proceeds mainly by renal excretion. The half-life of elimination depends on the molecular structure and varies between 2 and 10 h. Impaired kidney function is expected to increase the half-life of elimination, though this effect is not always observed. Since the 4-oxo-metabolites show a higher renal clearance than the parent drug, renal impairment will result in a cumulation of the metabolites in the body. PMID:3960691

  10. Sup(123)I excretion in breast milk - additional data

    Energy Technology Data Exchange (ETDEWEB)

    Lawes, S.C. (Queen' s Medical Centre, Nottingham (United Kingdom))

    1992-07-01

    A woman with a suspected sublingual thyroid was referred for thyroid imaging with {sup 123}I-sodium iodide. On attending it was ascertained that she was currently breastfeeding her 3-month-old baby. Reference to the available literature showed little information regarding the excretion of {sup 123}I-sodium iodide in human breast milk apart from one single case. It was felt therefore that this would be an ideal opportunity to collect some useful data. Originally the presence of impurities in the radiopharmaceutical administered had been discounted as being of little significance. However, after consideration, a review of the contribution of any impurity was undertaken. (author).

  11. Albumin-based nanocomposite spheres for advanced drug delivery systems.

    Science.gov (United States)

    Misak, Heath E; Asmatulu, Ramazan; Gopu, Janani S; Man, Ka-Poh; Zacharias, Nora M; Wooley, Paul H; Yang, Shang-You

    2014-01-01

    A novel drug delivery system incorporating human serum albumin, poly(lactic-co-glycolic acid, magnetite nanoparticles, and therapeutic agent(s) was developed for potential application in the treatment of diseases such as rheumatoid arthritis and skin cancer. An oil-in-oil emulsion/solvent evaporation (O/OSE) method was modified to produce a drug delivery system with a diameter of 0.5–2 μm. The diameter was mainly controlled by adjusting the viscosity of albumin in the discontinuous phase of the O/OSE method. The drug-release study showed that the release of drug and albumin was mostly dependent on the albumin content of the drug delivery system, which is very similar to the drug occlusion-mesopore model. Cytotoxicity tests indicated that increasing the albumin content in the drug delivery system increased cell viability, possibly due to the improved biocompatibility of the system. Overall, these studies show that the proposed system could be a viable option as a drug delivery system in the treatment of many illnesses, such as rheumatoid arthritis, and skin and breast cancers. PMID:24106002

  12. From monster to twin reversed arterial perfusion: a history of acardiac twins.

    Science.gov (United States)

    Obladen, Michael

    2010-05-01

    A human being born without heart and head, i.e., the acardius/acranius malformation, has been described since antiquity. Superstition and fear made it a mystical disorder, a sign of God's wrath. The inquisition ruled that acranic infants should not be baptized and located the soul in the brain. Acardia was not associated with twin gestation until the reports of Mery in 1720 and Winslow in 1740. In 1850, Meckel identified the pathogenetic mechanism as reversed perfusion due to large arterio-arterial and veno-venous anastomoses; he believed the heart would fail to develop or arrest during development, and the acardiac fetus would be maintained by arterial perfusion from the pump twin. In 1859, Claudius articulated that after normal initial development, the heart degenerates when reversed flow in the aorta leads to thrombosis. Today, it is assumed that both mechanisms may exist. With the advent of prenatal ultrasound diagnosis and radiofrequency ablation of the acardiac twin's circulation, it became possible to save the pump twin.

  13. [Gestational diabetes insipidus during a twin pregnancy].

    Science.gov (United States)

    De Mesmay, M; Rigouzzo, A; Bui, T; Louvet, N; Constant, I

    2013-02-01

    Gestational diabetes insipidus is an uncommon clinical disease whose prevalence is approximately two to three pregnancies per 100,000. It may be isolated or associated with preeclampsia. We report a case of gestational diabetes insipidus in a twin pregnancy, originally isolated during two months, and secondarily complicated by HELLP-syndrome. We recall the specific pathophysiology of polyuric-polydipsic syndrome during pregnancy and summarize its various causes. Finally, we discuss the indications, in case of isolated gestational diabetes insipidus, of treatment by dDAVP.

  14. Renal catabolism of albumin – current views and controversies

    Directory of Open Access Journals (Sweden)

    Jakub Gburek

    2011-10-01

    Full Text Available Albumin is the main protein of blood plasma, lymph, cerebrospinal fluid and interstitial fluid. The protein assists in many important body functions, including maintenance of proper colloidal osmotic pressure, transport of important metabolites and antioxidant action. Synthesis of albumin takes place mainly in the liver, and its catabolism occurs mostly in vascular endothelium of muscle, skin and liver as well as in the kidney tubular epithelium. Renal catabolism of albumin consists of glomerular filtration and tubular reabsorption. The tubular processes include endocytosis via the multiligand scavenger receptor tandem megalin and cubilin-amnionless complex. Possible ways of further catabolism of this protein are lysosomal proteolysis to amino acids and short peptides, recycling of degradation products into the bloodstream and tubular lumen or transcytosis of whole molecules. The article discusses the molecular aspects of these processes and presents the controversies arising in the light of the last decade of research.

  15. Adherence of platelets to in situ albumin-binding surfaces under flow conditions: role of surface-adsorbed albumin

    International Nuclear Information System (INIS)

    Surfaces that preferentially bind human serum albumin (HSA) were generated by grafting albumin-binding linear peptide (LP1) onto silicon surfaces. The research aim was to evaluate the adsorption pattern of proteins and the adhesion of platelets from platelet-poor plasma and platelet-rich plasma, respectively, by albumin-binding surfaces under physiological shear rate (96 and 319 s−1) conditions. Bound proteins were quantified using enzyme-linked immunosorbent assays (ELISAs) and two-dimensional gel electrophoresis. A ratio of ∼1000:100:1 of adsorbed HSA, human immunoglobulin (HIgG) and human fibrinogen (HFib) was noted, respectively, on LP1-functionalized surfaces, and a ratio of ∼5:2:1 of the same was noted on control surfaces, as confirmed by ELISAs. The surface-adsorbed von Willebrand factor was undetectable by sensitive ELISAs. The amount of adhered platelets correlated with the ratio of adsorbed HSA/HFib. Platelet morphology was more rounded on LP1-functionalized surfaces when compared to control surfaces. The platelet adhesion response on albumin-binding surfaces can be explained by the reduction in the co-adsorption of other plasma proteins in a surface environment where there is an excess of albumin molecules, coupled with restrictions in the conformational transitions of other surface-adsorbed proteins into hemostatically active forms. (paper)

  16. A Twin-Family Study of General IQ

    Science.gov (United States)

    van Leeuwen, Marieke; van den Berg, Stephanie M.; Boomsma, Dorret I.

    2008-01-01

    In this paper we assess the presence of assortative mating, gene-environment interaction and the heritability of intelligence in childhood using a twin family design with twins, their siblings and parents from 112 families. We evaluate two competing hypotheses about the cause of assortative mating in intelligence: social homogamy and phenotypic…

  17. Genetic influences on dietary variety - Results from a twin study

    NARCIS (Netherlands)

    Scheibehenne, Benjamin; Todd, Peter M.; Berg, van den S.M.; Hatemi, Peter K.; Eaves, Lindon J.; Vogler, Christian

    2014-01-01

    The heritability of variety seeking in the food domain was estimated from a large sample (N = 5,543) of middle age to elderly monozygotic and dizygotic twins from the “Virginia 30,000” twin study. Different dietary variety scores were calculated based on a semi-quantitative food choice questionnaire

  18. Annealing Twinning and the Nucleation of Recrystallization at Grain Boundaries

    DEFF Research Database (Denmark)

    Jones, A R.

    1981-01-01

    Experimental evidence is presented which shows that, in three different low stacking fault energy materials, annealing twins form at grain boundaries during the very early stages of recovery following deformation. These observations provide the basis for the suggestion that twinning at grain...

  19. Comparison of academic performance of twins and singletons in adolescence

    DEFF Research Database (Denmark)

    Christensen, Kaare; Petersen, Inge; Skytthe, Axel;

    2006-01-01

    of test scores for twins and singletons (difference 0.04, 95% confidence interval -0.03 to 0.10). A significant, positive association between test score and birth weight was observed in both twins and singletons, but the size of the effect was small: 0.06-0.12 standard deviations for every kilogram...

  20. Risk for multiple sclerosis in dizygotic and monozygotic twins

    DEFF Research Database (Denmark)

    Hansen, Thomas; Skytthe, Axel; Stenager, Egon;

    2005-01-01

    We investigated the risks of twins for multiple sclerosis (MS). Our data are linked registers of all Danish twins and of all Danes born between 1920 and 1970 in whom MS was diagnosed before 1997. We compared differences in the risks for MS by Cox regression and standardized incidence ratios. Our ...

  1. Distribution of Prime Numbers,twin Primes and Goldbach Conjecture

    OpenAIRE

    Ganguly, Subhajit

    2012-01-01

    The following paper deals with the distribution of prime numbers, the twin prime numbers and the Goldbach conjecture. Starting from the simple assertion that prime numbers are never even, a rule for the distribution of primes is arrived at. Following the same approach, the twin prime conjecture and the Goldbach conjecture are found to be true.

  2. Regularities of Twin, Triplet and Multiplet Prime Numbers

    OpenAIRE

    Weber, H. J.

    2011-01-01

    Classifications of twin primes are established and then applied to triplets that generalize to all higher multiplets. Mersenne and Fermat twins and triplets are treated in this framework. Regular prime number multiplets are related to quadratic and cubic prime number generating polynomials.

  3. Consequences of vanishing twins in IVF/ICSI pregnancies

    DEFF Research Database (Denmark)

    Pinborg, Anja Bisgaard; Lidegaard, Ojvind; la Cour Freiesleben, Nina;

    2005-01-01

    Spontaneous reductions are a possible cause of the increased morbidity in IVF singletons. The aim of this study was to assess incidence rates of spontaneous reductions in IVF/ICSI twin pregnancies and to compare short- and long-term morbidity in survivors of a vanishing co-twin with singletons...

  4. Gender Differences in Mother-Neonate Twin Interaction.

    Science.gov (United States)

    Riese, Marilyn L.

    To investigate differences in mothers' interaction patterns with their neonate twins based on birth order, relative size at birth, or gender, 37 neonate twins and their mothers were observed during the first 10 minutes of a feeding in a hospital nursery. Time-sampling recordings were made of maternal behaviors related to proximal stimulation,…

  5. Gamma-rays from dark showers with twin Higgs models

    Science.gov (United States)

    Freytsis, Marat; Knapen, Simon; Robinson, Dean J.; Tsai, Yuhsin

    2016-05-01

    We consider a twin WIMP scenario whose twin sector contains a full dark copy of the SM hadrons, where the lightest twin particles are twin pions. By analogy to the standard WIMP paradigm, the dark matter (DM) freezes out through twin electroweak interactions, and annihilates into a dark shower of light twin hadrons. These are either stable or decay predominantly to standard model (SM) photons. We show that this `hadrosymmetric' scenario can be consistent with all applicable astrophysical, cosmological and collider constraints. In order to decay the twin hadrons before the big-bang nucleosynthesis epoch, an additional portal between the SM and twin sector is required. In most cases we find this additional mediator is within reach of either the LHC or future intensity frontier experiments. Furthermore, we conduct simulations of the dark shower and consequent photon spectra. We find that fits of these spectra to the claimed galactic center gamma-ray excess seen by Fermi -LAT non-trivially coincide with regions of parameter space that both successfully generate the observed DM abundance and exhibit minimal fine-tuning.

  6. Effect of Configuration Pitching Motion on Twin Tail Buffet Response

    Science.gov (United States)

    Sheta, Essam F.; Kandil, Osama A.

    1998-01-01

    The effect of dynamic pitch-up motion of delta wing on twin-tail buffet response is investigated. The computational model consists of a delta wing-twin tail configuration. The computations are carried out on a dynamic multi-block grid structure. This multidisciplinary problem is solved using three sets of equations which consists of the unsteady Navier-Stokes equations, the aeroelastic equations, and the grid displacement equations. The configuration is pitched-up from zero up to 60 deg. angle of attack, and the freestream Mach number and Reynolds number are 0.3 and 1.25 million, respectively. With the twin tail fixed as rigid surfaces and with no-forced pitch-up motion, the problem is solved for the initial flow conditions. Next, the problem is solved for the twin-tail response for uncoupled bending and torsional vibrations due to the unsteady loads on the twin tail and due to the forced pitch-up motion. The dynamic pitch-up problem is also solved for the flow response with the twin tail kept rigid. The configuration is investigated for inboard position of the twin tail which corresponds to a separation distance between the twin tail of 33% wing chord. The computed results are compared with the available experimental data.

  7. The bioethics of separating conjoined twins in plastic surgery.

    Science.gov (United States)

    Lee, Michelle; Gosain, Arun K; Becker, Devra

    2011-10-01

    The incidence of craniopagus twins approximates four to six per 10 million births. Although rare, surgical separation of conjoined twins poses significant technical and ethical challenges. The present report uses the case of craniopagus twins AD and TD to examine the bioethical issues faced by a multidisciplinary medical team in planning the separation of craniopagus twins. AD and TD are craniopagus twins conjoined at the head. TD's head is conjoined to the back of AD's head. Neurologically, AD has the dominant cerebral circulation. TD has two normal kidneys, whereas AD has none. AD depends on TD's renal function and, on separation, will require either a kidney transplant or lifelong dialysis. This case report reviews one approach to analyzing and solving complex ethical dilemmas in pediatric plastic surgery. The principles reviewed are (1) autonomy and informed consent, focusing especially on the role of children in the informed consent process; (2) beneficence and nonmaleficence, two intricately intertwined principles because separation could potentially cause irreversible harm to one twin while improving the quality of life for the other (as separation is not a life-saving procedure, is it ethical to perform a procedure with unknown surgical risk to improve children's quality of life?); and (3) justice (is it fair to allocate excessive medical resources for the twins' separation?). The present report explores the ethics behind such decisions with respect to the separation of conjoined twins.

  8. Netherlands Twin Register : a focus on longitudinal research

    NARCIS (Netherlands)

    Boomsma, DI; Vink, JM; van Beijsterveldt, TCEM; de Geus, EJC; Beem, AL; Mulder, EJCM; Derks, EM; Riese, H; Willemsen, GAHM; Bartels, M; van den Berg, M; Kupper, NHM; Polderman, TJC; Posthuma, D; Rietveld, MJH; Stubbe, JH; Knol, LI; Stroet, T; van Baal, GCM

    2002-01-01

    In 1986 we began The Netherlands Twin Register (NTR) by recruiting young twins and multiples a few weeks or months after birth. Currently we register around 50% of all newborn multiples in The Netherlands. Their parents receive a questionnaire at registration and afterwards when the children are 2,

  9. Salivary cortisol in unaffected twins discordant for affective disorder

    DEFF Research Database (Denmark)

    Vinberg, Maj; Bennike, Bente; Kyvik, Kirsten Ohm;

    2008-01-01

    Dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as a biological endophenotype for affective disorders. In the present study the hypothesis that a high genetic liability to affective disorder is associated with higher cortisol levels was tested in a cross-sectional h......Dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as a biological endophenotype for affective disorders. In the present study the hypothesis that a high genetic liability to affective disorder is associated with higher cortisol levels was tested in a cross......-sectional high-risk study. Healthy monozygotic (MZ) and dizygotic (DZ) twins with (High-Risk twins) and without (Low-Risk twins) a co-twin history of affective disorder were identified through nationwide registers. Awakening and evening salivary cortisol levels were compared between the 190 High- and Low......-Risk twins. The 109 High-Risk twins had significantly higher evening cortisol levels than the 81 Low-Risk MZ twins, also after adjustment for age, sex, and the level of subclinical depressive symptoms. No significant difference was found in awakening cortisol levels between High-Risk and Low-Risk twins...

  10. Twin-Pulse Soliton Operation of a Fiber Laser

    Institute of Scientific and Technical Information of China (English)

    W.; S.; Man; H.; Y.; Tam

    2003-01-01

    We report on the experimental observation of a novel type of twin-pulse soliton in a passively mode-locked fiber ring laser. Twin-pulse soliton interaction in the laser cavity are also experimentally investigated and compared with those of the single pulse soliton.

  11. Pretend Play as Twin Earth: A Social-Cognitive Analysis.

    Science.gov (United States)

    Lillard, Angeline

    2001-01-01

    Presents the Twin Earth model, proposing specific relations between pretend play and understanding minds, from ontogenesis of pretense to later emergence of role play and representational understandings of pretense. Central to the model is supposition that pretend play functions for children much as Twin Earth functions for philosophers, by…

  12. Red Yeast Rice Increases Excretion of Bile Acids in Hamsters

    Institute of Scientific and Technical Information of China (English)

    KA-YING MA; ZE-SHENG ZHANG; SHU-XIN ZHAO; QI CHANG; YIN-MEI WONG; SAI YING VENUS YEUNG; YU HUANG; ZHEN-YU CHEN

    2009-01-01

    Objectives To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism. Methods Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR (0.1RYR) or 0.3% RYR (0.3RYR). Blood (0.5 mL) was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0,3, and 6.Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography. Results Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by ll% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, liver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7α-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K.It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 3-4 folds compared with the control value. Conclusion Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion.

  13. Retention and excretion of 95Zr-95Nb in humans.

    Science.gov (United States)

    Thind, K S

    1995-12-01

    This note describes the retention and excretion of 95Zr-95Nb in humans based on a recent CANDU experience and a literature survey of reported cases. Two data bases, QUEST and INIS were used for the survey. Three reported cases were discovered: two for occupational exposures and one for public exposure from nuclear weapons fallout. Human lung retention from these three cases, plus whole body retention and some limited fecal excretion data from a recently occurred exposure at a CANDU station, were reviewed and tested against predictions based on ICRP Publication 30 model. Based on the fits of this model to the reported data it seems that the three occupational exposures exhibit class Y behavior while the public exposure exhibits class W behavior. For only one case is the chemical compound known with certainty: ZrO2. Zirconium oxides are currently classified as class W in ICRP Publications 30 and 54. This work confirms a suggestion that oxides of zirconium be classified as class Y and should be taken into account by the ICRP in its future publications. PMID:7493813

  14. Retention and excretion of 95Zr-95Nb in humans.

    Science.gov (United States)

    Thind, K S

    1995-12-01

    This note describes the retention and excretion of 95Zr-95Nb in humans based on a recent CANDU experience and a literature survey of reported cases. Two data bases, QUEST and INIS were used for the survey. Three reported cases were discovered: two for occupational exposures and one for public exposure from nuclear weapons fallout. Human lung retention from these three cases, plus whole body retention and some limited fecal excretion data from a recently occurred exposure at a CANDU station, were reviewed and tested against predictions based on ICRP Publication 30 model. Based on the fits of this model to the reported data it seems that the three occupational exposures exhibit class Y behavior while the public exposure exhibits class W behavior. For only one case is the chemical compound known with certainty: ZrO2. Zirconium oxides are currently classified as class W in ICRP Publications 30 and 54. This work confirms a suggestion that oxides of zirconium be classified as class Y and should be taken into account by the ICRP in its future publications.

  15. RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS

    Directory of Open Access Journals (Sweden)

    Z. IQBAL, I. JAVED, B. ASLAM, F. MUHAMMAD AND I. U. JAN

    2007-10-01

    Full Text Available The renal clearance and urinary excretion of ciprofloxacin were investigated in eight healthy female goats. In each animal, ciprofloxacin was administered intramuscularly at the rate of 5 mg/kg body weight. Following drug administration, blood and urine samples were collected at different time intervals and analyzed for ciprofloxacin and creatinine. High performance liquid chromatography (HPLC was used to determine the drug concentration in the plasma and urine. The value of diuresis after single administration of ciprofloxacin was 0.073 ± 0.014 ml/min/kg. Mean (± SE values for renal clearance of creatinine and ciprofloxacin were 1.870 ± 0.385 and 0.982 ± 0.166 ml/min/kg, respectively. The ratio between the renal clearance of ciprofloxacin and that of creatinine remained less than one, which was indicative of back diffusion. The mean (± SE value for the cumulative percent of ciprofloxacin dose excreted at 10 hours following its intramuscular administration was 13.03 ± 2.07. Based on these results, it was evident that besides glomerular filtration, renal handling of drug involved back diffusion also. It was concluded that in local goats glomerular filtration rate (GFR was lower than that reported for their foreign counterparts.

  16. I. 'Street of twins': multiple births in Cuba II. The Cuban twin registry: an update / twin research reports: cord entanglement; heritability of clubfoot; school separation / twins and twin researchers in the news: reunited at seventy-eight; basketball duo dissolved; delivered holding hands; the better brew; award winners.

    Science.gov (United States)

    Segal, Nancy L; Marcheco-Teruel, Beatriz

    2014-08-01

    I was part of a people-to-people tour of Havana, Cuba during the first week in April 2014. Among the many highlights of that adventure were an informal meeting with Dr Beatriz Marcheco-Teruel, from Cuba's National Center for Medical Genetics, and a visit to the famous 'Street of Twins'. A fortuitous meeting with parents of twins in the fishing town of Jaimanitas was also an extraordinary event. The Cuban experience is followed by summaries of recent twin research, covering umbilical cord entanglement, the heritability of clubfoot and school separation policies for twins. Media reports include twins reunited at age 78, the future of UCLA's twin basketball players, MZ twins born holding hands, a twin conflict over beer and a pair of American Psychological Association honors for Drs Nancy L. Segal and Thomas J. Bouchard, Jr.

  17. Radiation-modified albumin in type 2 diabetic patients

    Directory of Open Access Journals (Sweden)

    Galina Gorbenko

    2013-02-01

    Full Text Available Objectives: Diabetes mellitus has been one of the most crippling diseases that man has seen, and its prevalence has risen dramatically over the past two decades. Currently, there are over 150 million diabetics worldwide and this number is likely to increase to 300 million or more by the year 2025. Diabetes mellitus increases the risk of many disorders including cardiovascular diseases. Understanding the molecular properties of diabetic progression is a big challenge in the system biology era. The aim of this study is to determine association in albumin modifications between Chernobyl clean-up workers with and without type 2 diabetes mellitus. Methods: ABM (3-aminobenzanthrone derivative developed in Daugavpils University, Latvia has been previously shown as a potential biomarker for determination of the immune state of patients with different pathologies. In this study several aspects of plasma albumin alterations in the group of Chernobyl clean-up workers with diabetes mellitus in relation to the group of workers without diabetes mellitus and people having no professional contact with radioactivity were determined. The following parameters were examined: (1 spectral characteristics of ABM in blood plasma; (2 effective and total albumin concentration in blood plasma; and (3 quantitative parameters of albumin auto-fluorescence. Results: Screening of individuals with diabetes mellitus 25-26 years after their work in Chernobyl revealed two groups of patients differing in structural and functional properties of membrane. The revealed structural modifications of membrane are dependent on radiation-induced factors. Concomitant diseases (diabetes mellitus, cardiovascular diseases reinforce radiation-induced effects. Conclusion: ABM is a sensitive probe of albumin alterations; it can be used to elucidate the changes in protein systems. Significant differences in albumin dynamics exist between the control group (donors and that of diabetics and non

  18. Twin plane re-entrant mechanism for catalytic nanowire growth.

    Science.gov (United States)

    Gamalski, Andrew D; Voorhees, Peter W; Ducati, Caterina; Sharma, Renu; Hofmann, Stephan

    2014-03-12

    A twin-plane based nanowire growth mechanism is established using Au catalyzed Ge nanowire growth as a model system. Video-rate lattice-resolved environmental transmission electron microscopy shows a convex, V-shaped liquid catalyst-nanowire growth interface for a ⟨112⟩ growth direction that is composed of two Ge {111} planes that meet at a twin boundary. Unlike bulk crystals, the nanowire geometry allows steady-state growth with a single twin boundary at the nanowire center. We suggest that the nucleation barrier at the twin-plane re-entrant groove is effectively reduced by the line energy, and hence the twin acts as a preferential nucleation site that dictates the lateral step flow cycle which constitutes nanowire growth.

  19. On the twin paradox in static spacetimes: I. Schwarzschild metric

    CERN Document Server

    Sokolowski, Leszek M

    2012-01-01

    Motivated by a conjecture put forward by Abramowicz and Bajtlik we reconsider the twin paradox in static spacetimes. According to a well known theorem in Lorentzian geometry the longest timelike worldline between two given points is the unique geodesic line without points conjugate to the initial point on the segment joining the two points. We calculate the proper times for static twins, for twins moving on a circular orbit (if it is a geodesic) around a centre of symmetry and for twins travelling on outgoing and ingoing radial timelike geodesics. We show that the twins on the radial geodesic worldlines are always the oldest ones and we explicitly find the conjugate points (if they exist) outside the relevant segments. As it is of its own mathematical interest, we find general Jacobi vector fields on the geodesic lines under consideration. In the first part of the work we investigate Schwarzschild geometry.

  20. Interaction of Point Defects with Twin Boundaries in Copper

    Institute of Scientific and Technical Information of China (English)

    S. A. Ahmad; Razia Ramzan

    2007-01-01

    The interaction between small vacancy clusters and twin boundaries in copper is studied by using many-body potential developed by Ackland et al. for fcc metals. The interaction energies of single-, dj- and tri-vacancy clusters with (111) and (112) twin boundaries are computed using well established simulation techniques. For (111) twins the vacancy clusters are highly repelled when they are on the adjacent planes, and are attracted when they are away from the boundary. In the case of (112) twins, vacancy clusters are more attracted to the boundary when they are near the boundary as compared to away from it. Vacancy clusters on both the sides of the boundary are also investigated, and it is observed that the clusters energetically prefer to lie on the off-mirror sites as compared to the mirror position across the twin.